cssi/SciSciGPT-SciSciNet huggingface dataset:
Supporting collaborative care in an emergency department (ED) through patient awareness

Patient-provider collaboration is considered crucial to successful patient care. However, while many CSCW and health informatics studies have focused on collaborative care incorporating patient awareness in chronic care management, very little attention has been given to emergency care. I am conducting a qualitative study of patient care trajectories in an emergency department (ED), examining patient awareness, decision-making and patient-clinician interaction in an information-imbalanced environment, particularly in situations of information deprivation. My research will enrich understandings of collaborative care practices in a hospital setting and can inform extended designs of the current provider-centric, socio-technical systems to incorporate patient-provider collaboration.
Content based sub-image retrieval system for high resolution pathology images using salient interest points

Content-based image retrieval systems for digital pathology require sub-image retrieval rather than the whole image retrieval for the system to be of clinical use. Digital pathology images are huge in size and thus the pathologist is interested in retrieving specific structures from the whole images in the database along with the previous diagnosis of the retrieved sub-image. We propose a content-based sub-image retrieval system (sCBIR) framework for high resolution digital pathology images. We utilize scale-invariant feature extraction and present an efficient and robust searching mechanism for indexing the images as well as for query execution of sub-image retrieval. We present a working sCBIR system and show results of testing our system on a set of queries for specific structures of interest for pathologists in clinical use. The outcomes of the sCBIR system are compared to manual search and there is an 80% match in the top five searches.
CLIENTS' VIEWS OF LIVE SUPERVISION AND SATISFACTION WITH THERAPY

In this study we examined clients' perceptions of live supervision and their satisfaction with therapy in a university-based training clinic for marriage and family therapists. A total of 108 clients completed the Client Satisfaction Questionnaire-8 and a modified version of the Purdue Live Observation Satisfaction Scale. Clients' comments on the advantages and disadvantages of live supervision were also solicited through short-answer questions. Results indicated that clients were generally satisfied with therapy and found the live-supervision process satisfactory as long as the perceived helpfulness of live supervision outweighed its perceived intrusiveness. The challenge for training clinics is striking a balance between helpfulness and intrusiveness in an effort to both train competent therapists and provide quality treatment.
Plasma Plume of Annular and Cylindrical Hall Thrusters

Hall thrusters hold considerable advantage over chemical thrusters and other kinds of electrical propulsion devices, except that the plume of the Hall thruster tends to be wide. An ongoing objective in Hall-thruster research is to narrow this plume. The plume is sensitive both to the specific geometry of the magnetic field as well as to the voltage potential induced within the plasma. Annular-geometry Hall thrusters tend to have narrower plumes. However, the cylindrical-geometry thruster has been shown to be suited particularly to low-power operation. New techniques have been advanced to narrow the Hall-thruster plumes. In this paper, images of the plasma plume in the two geometries of the Hall thruster are presented.
Bleaching/blinking assisted localization microscopy for superresolution imaging using standard fluorescent molecules

Superresolution imaging techniques based on the precise localization of single molecules, such as photoactivated localization microscopy (PALM) and stochastic optical reconstruction microscopy (STORM), achieve high resolution by fitting images of single fluorescent molecules with a theoretical Gaussian to localize them with a precision on the order of tens of nanometers. PALM/STORM rely on photoactivated proteins or photoswitching dyes, respectively, which makes them technically challenging. We present a simple and practical way of producing point localization-based superresolution images that does not require photoactivatable or photoswitching probes. Called bleaching/blinking assisted localization microscopy (BaLM), the technique relies on the intrinsic bleaching and blinking behaviors characteristic of all commonly used fluorescent probes. To detect single fluorophores, we simply acquire a stream of fluorescence images. Fluorophore bleach or blink-off events are detected by subtracting from each image of the series the subsequent image. Similarly, blink-on events are detected by subtracting from each frame the previous one. After image subtractions, fluorescence emission signals from single fluorophores are identified and the localizations are determined by fitting the fluorescence intensity distribution with a theoretical Gaussian. We also show that BaLM works with a spectrum of fluorescent molecules in the same sample. Thus, BaLM extends single molecule-based superresolution localization to samples labeled with multiple conventional fluorescent probes.
Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens.

In warm-blooded vertebrates it is generally accepted that after early stages of development new neurons are not added to the retina. Contrary to this belief, we show here that hatched chickens have a zone of proliferating cells at the peripheral margin of the retina, similar to that of fish and amphibians. We found that cells at the peripheral edge of the retina incorporated the thymidine analog BrdU and expressed the cell cycle regulator proliferating cell nuclear antigen (PCNA). Furthermore, cells in the ciliary epithelium and retinal margin coexpressed the homeodomain transcription factors Pax6 and Chx-10, similar to multipotent progenitors of embryonic retina. Expression of PCNA, Pax6, and Chx-10 in cells at the retinal margin was maintained in adult birds. Double-labeling studies showed that BrdU-labeled cells that were integrated into the retina expressed proteins found only in differentiated neurons. Increased rates of ocular growth, induced by visual deprivation, resulted in increased numbers of BrdU-labeled cells at the retinal margin. Unlike the progenitors in the retinal marginal zone of fish and amphibians, the progenitors of the chick retina do not increase their rate of proliferation in response to acute damage. Furthermore, insulin, insulin-like growth factor-I, and epidermal growth factor increased proliferation of progenitors at the retinal margin, while basic fibroblast growth factor had no effect. These results indicate that the avian retina has a marginal growth zone containing proliferating cells that share similarities with multipotent embryonic retinal progenitors and the retinal stem cells of cold-blooded vertebrates.
Species difference in the urinary excretion of isatinecic acid from the pyrrolizidine alkaloid retrorsine.

Abstract 1. The urinary excretion of the metabolites, isatinecic acid and pyrrolic metabolites from the pyrrolizicline alkaloid retrorsine were lower in the resistant species, guinea-pigs, than the susceptible species, mice, hamsters and rats. 2. The urinary N -oxides levels, however, were higher in guinea-pigs relative to mice, hamsters and rats. 3. These results conform to the postulate that a common metabolic pathway exists between the formation of isatinecic acid and pyrrolic metabolites. 4. The resistance of guinea-pigs to PA poisoning is attributed to the high metabolism of PAs to N -oxides combined with a corresponding low conversion to pyrrolic metabolites.
Dynamic code region (DCR) based program phase tracking and prediction for dynamic optimizations

Detecting and predicting a program's execution phases are crucial to dynamic optimizations and dynamically adaptable systems. This paper shows that a phase can be associated with dynamic code regions embedded in loops and procedures which are primary targets of compiler optimizations. This paper proposes a new phase tracking hardware, especially for dynamic optimizations, that effectively identifies and accurately predicts program phases by exploiting program control flow information. Our proposed phase tracking hardware uses a simple stack and a phase signature table to track the change of phase signature between dynamic code regions. Several design parameters of our proposed phase tracking hardware are evaluated on 10 SPEC CPU2000 benchmarks. Our proposed phase tracking hardware effectively identifies a phase at a given granularity. It correctly predicts the next program phase for 84.9% of times with a comparable small performance variance within the same phase. A longer phase length and higher phase prediction accuracy together with a reasonably small performance variance are essential to build more efficient dynamic profiling and optimization systems.
Deducing Anomalous Wave Source Regions during the Life Cycles of Persistent Flow Anomalies

Abstract Anomalous wave source regions are identified during the life cycles of persistent flow anomalies occurring over the North Pacific and North Atlantic Oceans during boreal winter. These cases project strongly upon the Pacific–North American and Eastern Atlantic teleconnection patterns, respectively, and represent two of the primary modes of intraseasonal low frequency variability in the Northern Hemisphere wintertime circulation. In the upper troposphere, these cases are manifested by wave trains of large-scale and large amplitude flow anomalies extending downstream from key regions near the Aleutian Islands and south of Iceland, respectively. The occurrence of persistent flow anomalies is closely linked to persistent extremes in surface weather and to variations in the skill of extended-range weather forecasts. Black and Dole performed a detailed diagnostic analysis of the onset of persistent cyclonic flow anomalies over the North Pacific. A key result of their study was that wave activity flux di...
A Critique of Social Justice as an Archival Imperative: What Is It We're Doing That's All That Important?

In recent years, a new and provocative thesis has been presented to the archival profession, to wit: to be an ethical archivist, one must pursue "social justice" in all phases of archival practice. While a professional agenda of social justice encompasses the more familiar ideology of "activist archivist," it stretches much farther and has much more profound consequences for our profession. This article challenges both the philosophy and utility of social justice as the end of archival effort and proposes an alternative goal for the profession.
An Indigenous Perspective of Brown v. Board of Education: An Historical Braid of Inequality

By examining the parallel inequality experiences of African-Americans and indigenous peoples in American history, I argue that a red-black interest convergence is revealed and that a political partnership is desirable and long overdue. I begin with an analogy of the two famous U.S. Supreme Court decisions (Brown v. Board of Education and Worcester v. Georgia) that guaranteed, but failed to provide, equality for African-Americans and indigenous peoples, respectively. In addition, I briefly evaluate select landmark legal, political, and policy decisions in American history to illustrate the much larger braid of inequality suffered by African-Americans and indigenous peoples in different time periods, but ultimately reflecting parallel experiences of removal, exclusion, and historical inequality. I contend that a red-black partnership would not likely transform American institutions, but it would serve as a powerful example of a multicultural coalition in spite of past and recent conflicts between African-Americans and indigenous peoples. Finally, I suggest universal responsibility to reach beyond the broken promises of Brown and Worcester and to redress the historical braid of inequality experienced by African-Americans and indigenous peoples since guaranteeing their basic rights to equality and political liberty is fundamental to, and reflects upon, the basic integrity of our republican democracy.
An automatic means to discriminate between earthquakes and quarry blasts

Abstract In this article we discuss our efforts to use the NORESS array to discriminate between regional earthquakes and ripple-fired quarry blasts (events that involve a number of subexplosions closely grouped in space and time). The method we describe is an extension of the time versus frequency “pattern-based” discriminant proposed by Hedlin et al. (1989b). At the heart of the discriminant is the observation that ripple-fired events tend to give rise to coda dominated by prominent spectral features that are independent of time and periodic in frequency. This spectral character is generally absent from the coda produced by earthquakes and “single-event” explosions. The discriminant originally proposed by Hedlin et al. (1989b) used data collected at 250 sec −1 by single sensors in the 1987 NRDC network in Kazakhstan, U.S.S.R. We have found that despite the relatively low digitization rate provide by the NORESS array (40 sec −1 ) we have had good success in our efforts to discriminate between earthquakes and quarry blasts by stacking all vertical array channels to improve signal-to-noise ratios. We describe our efforts to automate the method, so that visual pattern recognition is not required, and to make it less susceptible to spurious time-independent spectral features not originating at the source. In essence, we compute a Fourier transform of the time-frequency matrix and examine the power levels representing energy that is periodic in frequency and independent of time. Since a double Fourier transform is involved, our method can be considered as an extension of “cepstral” analysis (Tribolet, 1979). We have found, however, that our approach is superior since it is cognizant of the time independence of the spectral features of interest. We use earthquakes to define what cepstral power is to be expected in the absence of ripple firing and search for events that violate this limit. The assessment of the likelihood that ripple firing occurred at the source is made automatically by the computer and is based on the extent to which the limit is violated.
In-situ measurements of fluorine and chlorine speciation and partitioning between melts and aqueous fluids in the Na2O-Al2O3-SiO2-H2O system

The effect of pressure and temperature on the structure of silicate melts coexisting with silica-saturated aqueous electrolyte fluids enriched in fluorine or chlorine in the Na 2 O-Al 2 O 3 -SiO 2 -H 2 O system has been described. In situ measurements were conducted with the samples at desired temperatures and pressures in a hydrothermal diamond-anvil cell (HDAC) by using microRaman and FTIR spectroscopy techniques. The data were acquired at temperatures and pressures up to 800 °C and 1264 MPa, respectively. In silicate melts, the intensity of the infrared bands assigned to the stretch vibration of OH-groups is smaller than those of coexisting molecular H 2 O when F and Cl are present in the melt structure. This difference reflects the interaction of F or Cl with H 2 O in the melts. With decreasing pressure and temperature ( P - T ) conditions, SiF complexes are favored in the melt over that in coexisting fluid, perhaps because of decreasing silicate concentration in fluids with decreasing temperature and pressure. In these melts, the solubility of Cl, likely in the form of NaCl, increases with decreasing P - T conditions, whereas the abundance of such complexes in coexisting fluids decreases in favor of HCl. Our experimental data were employed to model the ascent of a fluid-saturated magma from the upper mantle to the shallow crust. This modeling offers insights into F and Cl partitioning between and the speciation of F and Cl in melts and magmatic fluids. We suggest that the formation of stable SiF and NaCl complexes and their increasing solubilities in silicate melts during magma ascent may explain the late volcanic degassing of F and Cl compared with the degassing behavior of other volatile species.
Reducing "Theory Anxiety" through Puzzles

L'A. souligne que les etudiants, dans le cadre de leur formation, doivent gerer une situation d'anxiete liee a l'apprentissage des theories sociologiques. Il estime que celles-ci leur apparaissent tres abstraites. Il presente une experience, menee aux Etats-Unis, qui vise a faire realiser par des petits groupes d'etudiants des puzzles et a leur faire analyser et expliquer la demarche qu'ils ont adoptee pour construire ces puzzles. Il affirme que, par ce biais, les etudiants sont amenes a prendre conscience du role et de la nature des theories sociologiques
Low-Power Split-Radix FFT Processors Using Radix-2 Butterfly Units

Split-radix fast Fourier transform (SRFFT) is an ideal candidate for the implementation of a low-power FFT processor, because it has the lowest number of arithmetic operations among all the FFT algorithms. In the design of such processors, an efficient addressing scheme for FFT data as well as twiddle factors is required. The signal flow graph of SRFFT is the same as radix-2 FFT, and therefore, the conventional address generation schemes of FFT data could also be applied to SRFFT. However, SRFFT has irregular locations of twiddle factors and forbids the application of radix-2 address generation methods. This brief presents a shared-memory low-power SRFFT processor architecture. We show that SRFFT can be computed by using a modified radix-2 butterfly unit. The butterfly unit exploits the multiplier-gating technique to save dynamic power at the expense of using more hardware resources. In addition, two novel address generation algorithms for both the trivial and nontrivial twiddle factors are developed. Simulation results show that compared with the conventional radix-2 shared-memory implementations, the proposed design achieves over 20% lower power consumption when computing a 1024-point complex-valued transform.
Stresses at the lumbosacral junction.

Summary This report has presented a discussion of the mechanics of the spine in terms of an analogy with a curved, tapered beam. We have identified the existence of critical frequencies and locations in the spine and discussed the evidence from clinical experience with low back problems. We have also discussed the extrinsic mechanisms for protecting the spine and the lumbosacral junction. The question of the sensitivity of the lumbosacral junction to shear forces has been raised and experiments described that show that the shear forces that will injure the posterior elements of the fifth lumbar vertebra are low and occur commonly. The report also describes an instrument to measure the stiffness of articulations of the spine.
The Medication Attribution Scale: perceived effects of antiretrovirals and quality of life.

This report describes the development and validation of an instrument to assess the attributions human immunodeficiency virus (HIV)-infected persons who are currently taking antiretrovirals make about the effects of these medications. The specific limitations in functioning that the subjects attributed to the effects of medication were assessed. The scores on a ten-item instrument were found to have high internal consistency reliability and to be related to beliefs about the benefits and barriers to taking antiretrovirals. The attribution that the use of antiretrovirals had contributed to an increase in depressive symptoms was related to reports of having temporarily discontinued use of antiretrovirals during the preceding month. The summated score on the Medication Attribution Scale (MAS) and other subscale scores were not found to predict selt-reported intentional alterations of treatment regimens. Multiple regression analyses indicated that negative attributions about the effects of medications contributed to the amount of variance in quality of life explained over and above that explained by perceived health status and level of symptomology.
Ensemble adaptive neuro fuzzy support vector machine for prediction of transient stability

A new method which achieves high accuracy in predicting the transient stability of power systems is presented. This study examines the application of Weighted Support Vector Machine (WSVM), ensemble WSVM and Adaptive Neuro Fuzzy Inference System (ANFIS) for prediction of post-fault transient stability condition. The performance of the ensemble classifier is compared with other methods for accuracy of prediction. The method is tested on the IEEE 39-bus test system. Results show that the ensemble method achieves the highest accuracy using both rotor angles of generators and bus voltage magnitudes after fault clearance. Additionally, the proposed method is investigated under different contingencies and topology alterations to evaluate its performance in determining the stability.
Graphene hybridization for energy storage applications

Graphene has attracted considerable attention due to its unique two-dimensional structure, high electronic mobility, exceptional thermal conductivity, excellent optical transmittance, good mechanical strength, and ultrahigh surface area. To meet the ever increasing demand for portable electronic products, electric vehicles, smart grids, and renewable energy integrations, hybridizing graphene with various functions and components has been demonstrated to be a versatile and powerful strategy to significantly enhance the performance of various energy storage systems such as lithium-ion batteries, supercapacitors and beyond, because such hybridization can result in synergistic effects that combine the best merits of involved components and confer new functions and properties, thereby improving the charge/discharge efficiencies and capabilities, energy/power densities, and cycle life of these energy storage systems. This review will focus on diverse graphene hybridization principles and strategies for energy storage applications, and the proposed outline is as follows. First, graphene and its fundamental properties, followed by graphene hybrids and related hybridization motivation, are introduced. Second, the developed hybridization formulas of using graphene for lithium-ion batteries are systematically categorized from the viewpoint of material structure design, bulk electrode construction, and material/electrode collaborative engineering; the latest representative progress on anodes and cathodes of lithium-ion batteries will be reviewed following such classifications. Third, similar hybridization formulas for graphene-based supercapacitor electrodes will be summarized and discussed as well. Fourth, the recently emerging hybridization formulas for other graphene-based energy storage devices will be briefed in combination with typical examples. Finally, future prospects and directions on the exploration of graphene hybridization toward the design and construction of viable, high-class, and even newly-featured (e.g., flexible) energy storage materials, electrodes, and systems will be presented.
Synthesis, microstructure, and mechanical properties of polycrystalline Cu nano-foam

A polycrystalline Cu foam with sub-micron ligament sizes was formed by creating a non-woven fabric via electrospinning with a homogeneous mixture of polyvinyl alcohol(PVA)-and copper acetate(Cu(Ac)2). Thermogravimetric measurement of the electrospun fabric of the precursor solution is reported. Oxidizing the precursor fabric at 773K formed an oxide nano-foam; subsequent heating at 573K with a reducing gas transformed the CuO nano-foam to Cu with a similar ligament and meso-scale pore size morphology. A cross-section prepared by focused ion beam lift-out shows the polycrystalline structure with multi-scale porosity. The mechanical property of the Cu nano-foam is measured by nano-indentation. The load-depth curves and deduced mechanical properties suggest that additional intra-ligament pores lead to unique structure-property relations in this non-conventional form of metal.
Role of routine transurethral biopsy and isolated upper tract cytology after intravesical treatment of high-grade non-muscle invasive bladder cancer.

Objectives: To investigate whether random bladder, and prostatic urethral biopsies and individual upper tract cytologies (restaging) provide useful clinical information in addition to cystoscopy and bladder cytology in assessing initial intravesical therapy response for high-grade non-muscle invasive bladder cancer. Methods: We retrospectively reviewed records of all patients who underwent restaging at our institution after treatment for high-grade non-muscle invasive bladder cancer (Ta, T1 and Tis) between January 2000 and October 2009. A total of 78 patients undergoing 116 consecutive restagings were included. The presence of intravesical cancer at restaging was assessed by cystoscopy, bladder wash cytology and random bladder biopsies, whereas ureteral and prostatic urethral disease was determined using upper tract barbotage cytology and prostatic urethral biopsies. Results: Indication for intravesical treatment was carcinoma in situ in 86, high-grade T1 in 16 and high-grade Ta in 14 cases. A total of 48 patients had primary disease and 68 had recurrence. Overall, 59 of 116 (50.9%) restagings showed positive bladder or prostatic biopsy and/or a positive cytology localized to the upper tract. Of the total number of recurrences, 12.9% (15 of 116) showed a negative cystoscopy and negative bladder cytology, and would have been missed on routine surveillance. A total of 23 of 116 (19.8%) restagings showed evidence of prostatic urethral and or ureteral disease. Conclusion: Roughly 25% of high-grade non-muscle invasive bladder cancer early recurrences after induction intravesical therapy would go unnoticed without the addition of random and directed prostate biopsies, and isolated upper tract cytologies to standard cystoscopy and bladder cytology.
Dissolved oxygen and fish distribution in a Florida spring

This study examined the distribution and relative abundance of fishes along a dissolved oxygen gradient in Singing Springs, Florida. Over the 1-year study, dissolved oxygen concentration in the spring exhibited a strong gradient ranging from an average of 0.20 mg l–2AM1 at the boil to 1.81 mg l–2AM1 110 meters downstream. Seasonal variation in dissolved oxygen was very low relative to the spatial variation along the spring gradient. Fish community composition was evaluated monthly at the boil of the spring, 45 m downstream just after the confluence of the spring and the main river, and 110 m downstream. The fish community in the spring was characterized by species generally considered to be tolerant of low oxygen. Gambusia holbrooki was the most abundant species at all sites comprising an average of 88.1% of the fish captured at the boil, 63.2% of the fish captured at 45 m, and 74.8% of the fish captured at 110 m downstream. The diversity of fishes (G. holbrooki, Heterandria formosa, Notropis harperi, Lucania goodei, and Poecilia latipinna) increased with distance from the boil. Although there were some seasonal differences in patterns of diversity and community structure, the inter-site differences were much more apparent throughout the study. It is likely that the pattern of variation in dissolved oxygen interacts with the respiratory abilities of the fishes to affect the distribution pattern and community composition along the gradient.
How the Internet of Things Will Change the User Experience Status Quo

The Internet of Things (IoT) will find its way into the way we work. As sensors and other connected devices invade our homes and places of work, we will expect an increase in new emergent ways to harness all this data to our advantage. Having intelligent context engines will be the glue that brings disparate data streams together. As we learn how we can use this data it will change the way we work and interact with our systems, effectively changing the User Experience (UX) status quo. This paper will explore the opportunities that IoT brings by collecting user data to help determine its context and offer a more compelling User Experience.
Cradle-to-gate environmental impacts of sulfur-based solid-state lithium batteries for electric vehicle applications

Abstract In this study, we investigate the cradle-to-gate environmental impacts of a pre-production sulfur-based solid-state lithium pyrite battery suitable for electric vehicle applications. We apply process-based attributional life cycle assessment methodology, utilizing laboratory data, literature, U.S. patents, and US-EI 2.2 life cycle inventory database to estimate the materials and energy required for the battery and its anticipated manufacturing and assembly processes. We estimate a mass of 440 kg and a specific capacity of 182 Wh kg−1 for a battery with 80 kWh energy capacity and 100 kW power, capable of powering a full-size battery electric vehicle with a 200-mile range. The estimated cumulative energy demand (CED) and global warming potential for a 100-year time horizon (GWP100) are 3300 MJ kWh−1 and 199 kg CO2 eq. kWh−1, respectively. The combination of direct and upstream energy associated with clean dry-room operation accounts for the biggest share of the total CED (75%) and GWP100 (73%), followed by the cathode paste (10% and 6%, respectively). The energy demand and environmental impacts of the clean dry-room and cathode paste present opportunities to improve production processes and reduce costs. CED and GWP100 impacts associated with battery production are lower than well-to-wheel energy consumption and emissions for a vehicle with the same size and range. The pyrite battery delivers higher specific capacity than the current Li-ion battery chemistries while its CED and GWP100 environmental impacts are comparable.
Innovation in the Social Sector: A Resource Exchange Perspective

Social innovation is a key facet of social entrepreneurship in both research and practice. We focus on the how social innovation is fostered. We draw on social exchange theory to explain how social...
Ticagrelor for Refractory Migraine/Patent Foramen Ovale (TRACTOR): An open-label pilot study

Objective After finding that the thienopyridines clopidogrel and prasugrel reduced migraine headache (MHA) symptoms in some patients with patent foramen ovale (PFO), this small pilot study was undertaken to determine whether ticagrelor, a nonthienopyridine P2Y12 inhibitor, would have similar MHA effects and might be better suited for a future randomized trial. Methods MHA patients were screened for PFO. Participants with documented right to left shunt (RLS) and ≥6 monthly MHA days received ticagrelor therapy for 28 days. Those with ≥50% reduction in monthly MHA days were deemed responders and completed 2 additional treatment months. Results The 40 participants had a mean age of 36.2 years and mean MHA frequency of 17.4 d/mo. A total of 39/40 were female. A total of 14/40 met criteria for episodic MHA, 26/40 for chronic MHA, 14/40 had migraine with aura, and 22/40 had a moderate–large RLS (Spencer grade ≥4). Seventeen of 40 participants (43%) were responders. MHA reduction continued through 3 treatment months in all responders. MHA responder rates were not statistically different in participants with episodic or chronic MHA, with or without aura, or with small/larger RLS shunt magnitude. Thirteen (32%) patients had medication side effects, without serious adverse events. Conclusion P2Y12 inhibition with ticagrelor reduced MHA symptoms similarly to our previous thienopyridine experience, but participants seemed to have a less robust MHA benefit and more frequent side effects than with the thienopyridines, making it an inferior choice for a randomized trial. Classification of evidence This study provides Class IV evidence that ticagrelor reduced MHA symptoms in patients with PFO.
Abstract 349: Sall4 Blocks Cardiac Trans-differentiation but Stimulates Cardiac Stem-like Cell (iPSC) Generation and Improve Post MI Function In Vivo

Background: Sall4 is an essential component in maintaining embryonic stem cell self-renewal and pluripotency. Given its functional and protein level interaction with cardiac trans-differentiation f...
Pathology of Experimental Nerve Agent Poisoning

Historically, organophosphorus toxicity has been most frequently associated with delayed peripheral neuropathies (Spencer, 1978; Lotti, 1984). Studies of accidental human exposures to these compounds and numerous animal experiments have shown that the symptomatic and morphologic effects of these toxic substances are related to distal disruptions of motor nerve tracts. The best described of these substances are triorthocresylphosphate (TOCP) and certain of the agricultural insecticides. More recently several investigators have defined an entirely different syndrome caused by two of the organophosphorus chemical warfare agents (Petras, 1981; Lemercier, 1983; McLeod, 1984; Samson, 1984; Martin, 1985; Singer, 1985; Singer, 1985). These highly toxic “nerve agents” are potent acetylcholinesterase inhibitors that have been found to induce severe brain pathology in several experimental animal models. The purpose of this review is to describe the light and electron microscopic pathological changes that are caused by these agents and to propose several possible etiologic mechanisms based on comparisons of observed lesions with other forms of central nervous system injury.
Understanding overfitting peaks in generalization error: Analytical risk curves for l 2 and l 1 penalized interpolation.

Traditionally in regression one minimizes the number of fitting parameters or uses smoothing/regularization to trade training (TE) and generalization error (GE). Driving TE to zero by increasing fitting degrees of freedom (dof) is expected to increase GE. However modern big-data approaches, including deep nets, seem to over-parametrize and send TE to zero (data interpolation) without impacting GE. Overparametrization has the benefit that global minima of the empirical loss function proliferate and become easier to find. These phenomena have drawn theoretical attention. Regression and classification algorithms have been shown that interpolate data but also generalize optimally. An interesting related phenomenon has been noted: the existence of non-monotonic risk curves, with a peak in GE with increasing dof. It was suggested that this peak separates a classical regime from a modern regime where over-parametrization improves performance. Similar over-fitting peaks were reported previously (statistical physics approach to learning) and attributed to increased fitting model flexibility. We introduce a generative and fitting model pair ("Misparametrized Sparse Regression" or MiSpaR) and show that the overfitting peak can be dissociated from the point at which the fitting function gains enough dof's to match the data generative model and thus provides good generalization. This complicates the interpretation of overfitting peaks as separating a "classical" from a "modern" regime. Data interpolation itself cannot guarantee good generalization: we need to study the interpolation with different penalty terms. We present analytical formulae for GE curves for MiSpaR with $l_2$ and $l_1$ penalties, in the interpolating limit $\lambda\rightarrow 0$.These risk curves exhibit important differences and help elucidate the underlying phenomena.
Concrete Grinding Residue: Management Practices and Reuse for Soil Stabilization:

Concrete grinding residue (CGR) is a slurry byproduct produced from diamond grinding operations used to smooth concrete pavement surface. As a waste material, CGR consists of cooling water for blad...
Real-time fluorescence imaging for visualization and drug uptake prediction during drug delivery by thermosensitive liposomes

AbstractObjective: Thermosensitive liposomal doxorubicin (TSL–Dox) is a promising stimuli-responsive nanoparticle drug delivery system that rapidly releases the contained drug in response to hypert...
Results-III. SIRT6 Is an Acetylated Protein and a NAD+-Dependent Self-deacetylase

This chapter establishes p300 and MOF-mediated acetylation as a novel post-translational modification of SIRT6, with implications in DNA damage responses. It further illustrates the self-deacetylation function of SIRT6 in the presence of NAD+.
Incarceration as a unique social stressor during pregnancy: Implications for maternal and newborn health.

Abstract Rationale Exposure to incarceration during pregnancy is a stressful life event that poses risk for both maternal and newborn health. Objective We conducted a pooled, cross-sectional analysis of the link between incarceration exposure of mothers during pregnancy – personally or vicariously through a romantic partner - and maternal and newborn health using data from the Pregnancy Risk Assessment Management System from years 2012–2015. Method We applied a novel approach that compares mothers who were exposed to incarceration to the strategic comparison group of mothers who were not exposed to incarceration, but experienced varying numbers of stressors. Results The initial findings indicated that respondents exposed to incarceration exhibited reductions in maternal and newborn health relative to respondents not exposed to incarceration. However, these differences were substantially attenuated when comparing the incarceration-exposed group to a more comparable stressor-exposed reference group. Conclusions While incarceration exposure has adverse consequences for health outcomes of mothers and newborns, incarceration exposure may not carry unique implications for maternal and newborn wellbeing beyond the clustering of other stressful life events. Policies targeting incarceration exposure as a means of promoting health must also provide adequate attention to co-occurring stressors.
Co-hydrothermal carbonization of coal waste and food waste: fuel characteristics

The goal of this study was to upgrade fuel properties of two different bituminous coal wastes (CW) by reducing their ash, sulfur, and chloride content through co-hydrothermal carbonization (co-HTC) with food waste (FW). CW and FW were mixed in 1:1 (dry wt. basis), ratio and co-HTC experiments were performed at three different temperatures of 180, 230, and 280 °C for 30 min. Mass yield, proximate and ultimate analyses, energy content, and combustion indices of hydrochars were evaluated for the fuel properties. Results showed that co-HTC at 230 °C produced hydrochar with maximum fixed carbon, elemental carbon, and higher heating value (HHV), as well as minimum sulfur and ash for both CW samples. At 230 °C, the elemental carbon of co-HTC hydrochar was increased to a maximum of 46.7 and 49.5%, and the energy content increased to 22.4 MJ/kg and 23.0 MJ/kg for CW1FW (co-HTC hydrochar of CW1 and FW) and CW2FW (co-HTC hydrochar of CW2 and FW), respectively. Additionally, the presence of FW in the treatment process reduced the sulfur content to 2.1 and 1.4% compared with the raw CW values of 9.6 and 8.5% for CW1 and CW2, respectively. Combustion indices also indicated that CW2FW-H230 hydrochar had combustion indices similar to bituminous coal.
Assessing Diabetes Risk Factors in Rural Dwelling Grandparent Caregivers

Objective:The purpose of this study is to assess type 2 diabetes mellitus (T2DM) risk factors in grandparent caregivers living in a rural environment.Methods:Clinical measures (hemoglobin A1c [HbA1...
Mitigation of the Microsoft HoloLens’ hardware limitations for a controlled product assembly process

Studies have shown that using augmented reality (AR) reduces time and errors by as much as 50% for manufacturing and assembly operations. The use of head-mounted displays (HMDs) is very interesting for these situations as they free up a user’s hands. However, with the technology behind these HMDs still under development, limitations in input, field of view, tracking, and occlusion exist. For AR assembly instructions to be effective, these limitations must be mitigated so that a user receives accurate instructions. To investigate this, an application was developed that guides a user through the assembly of a mock aircraft wing using AR on a Microsoft HoloLens 1. The application displays 3D work instructions, user interfaces, and spatially registered content. To ensure accurate instructions were displayed, techniques were developed to mitigate the HoloLens’ tracking and display limitations. Image tracking was implemented to augment the HoloLens’ limited position determination, stabilize spatially registered virtual content, and account for spatial drift. Also, 3D augmented content was optimized for clarity through the display using specialized computer graphics methods. Lastly, the system provides raw data regarding head position, orientation, and assembly step times. A visualization application was developed that combines this information with wearable sensor data, to examine trends exhibited by a user during the assembly tasks and validate the delivered instructions. The outcomes of this research provided solutions to address limitations of the HoloLens for broad use.
Do Materialistic Adolescents Ruminate More About Their Social Media Posts

Previous research suggests that ruminating on social media content is associated with greater mental distress (Yang et al., 2018). This study examined whether materialistic value orientation (MVO)—...
Alterations in Surface Electromyography of the Upper Leg Muscles at Specified Respiratory Exchange Ratio Thresholds Ranges During a Maximal Exercise Test

Introduction: Assessing muscle electromyography (EMG) in conjunction with physiological alterations to exercise may be valuable to determine a more holistic approach to exercise-induced fatigue. Methods: Thirteen, recreationally trained individuals (n = 7 female, n = 6 males) underwent a maximal exercise test. Throughout the test, physiological variables were measured in addition to surface electromyography (sEMG) of the upper legs. Physiological and sEMG data was then grouped in to four category thresholds based on respiratory exchange ratios (RER) greater than 0.95. Results: There was a main effect of group (p < 0.001) as an increase in exercise intensity assessed by RER threshold ranges resulted in a subsequent reductions in sEMG frequencies with the exception of the sEMG frequencies recorded at VO2peak (p < 0.055). Conclusions: Upper leg sEMG frequencies decrease with increases in high intensity exercise, with the exception of near maximal loads.
Phase II Study of Adjuvant Scanned Proton Beam Radiation Therapy for Node-positive Cancer of the Uterus and Cervix.

Purpose/objective(s) Patients with node-positive (LN+) uterine or cervical cancer often require adjuvant radiation to the pelvis and para-aortics, resulting in significant acute and late gastrointestinal (GI) and genitourinary (GU) toxicity. Proton therapy allows for more conformal delivery of radiation dose. The objective was to prospectively evaluate the safety and efficacy of proton beam radiation therapy (RT) for patients with LN+ uterine or cervical cancer requiring RT. Materials/methods Patients with IIIC uterine and pT1,2N1M0 cervical cancer status post hysterectomy and lymphadenectomy were eligible. Sequential (uterine) and concurrent (cervical) chemotherapy were allowed. Exclusion criteria included life expectancy Results 21 patients completed RT between 10/2013 and 10/2018. Median follow-up is 52.3 months (range, 11.2-63.4). Median age was 59.7 years (range, 31.5-79.2). 15 patients had IIIC uterine cancer (13 endometrioid) and 6 patients had cervical cancer. 52% received sequential and 29% received concurrent chemotherapy. Median dose was 45.0 Gy (RBE). 20 (95%) received VB boost. 4 received PRT and 17 EFRT. Acute grade 2 and 3 GI toxicity was 24% and 14%, respectively. Acute grade 2 and 3 GU toxicity was 10% and 0%, respectively. Acute grade 2 and 3 hematologic toxicity was 24% and 0%, respectively. To date, there have been no late toxicities > grade 3. The 2-year PFS was 81% (95% CI, 56%-92%). Of the 5 patients that recurred, 4 were peritoneal and 1 was abdominal wall and lung; no recurrences were in-field. The 2-year OS was 86% (95% CI, 62%-95%). Conclusion Scanned proton beam RT appears effective in preventing local-regional recurrence in LN+ patients with uterine and cervical cancer undergoing adjuvant radiation. Acute toxicity is low and severe late effects have not been observed but await longer follow-up. Author disclosure A.L. Russo: None. K.D. Bernstein: None. S.P. Nisbet: None. N. Horick: None. N. Depauw: None. B.Y. Yeap: None. H.M. Kooy: None. T.F. DeLaney: None. A.H. Russell: None.
Large deviation results for branching processes in fixed and random environments

Let {Z„: n > 0} be a p-type {p > 2) supercritical branching process f t ' Z £ ' ( Z M ) \ with mean matrix M. It is known that for any £'m W, I -—^ \ 1 • Z n 1 • Z n J ( i Z n I RRR I Converge to 0 with probability one on the set of non-extinction \1-Z„ where is the left eigenvector of M corresponding to its maximal eigenvalue p. In this paper we study the large deviation aspects of this convergence. It is shown that the large deviation probabilities for these two sequences decay geometrically and under appropriate conditioning supergeometrically.
Contactless approaches for RF characterization of metallic nanowires

Two approaches for microwave characterization of nanowire (NW) conductivity are described in this paper. To remove the uncertainty associated with contacts, the NWs are either suspended above the center conductor of a coplanar waveguide (CPW) host or embedded in the same plane within a serrated conductor. Broadband measurements and full-wave finite element modeling of the measurement setup are performed to determine the conductivity of the Pt NWs. Fabrication and measurements are conducted for modeling validation and characterizing the devices embedded the NWs. Sensitivity studies with three different conductivities for the two structure are carried out by simulations. Results have shown that the conductivity of the Pt NWs significantly affects the S-parameter response of the tested devices, and that both approaches are suitable to characterize the NWs.
Nutrient media for plant-parasitic nematodes: II. Amino acid requirements of Aphelenchoides sp.

Abstract Amino acid requirements of Aphelenchoides sp. were determined by the labeling and deletion methods. Histidine and methionine were not synthesized and they were classified as absolute dietary requirements. Alanine, glycine, serine, proline and valine contained low levels of radioactivity and were classified as limited requirements by both methods. Heavily labeled or rapidly synthesized aspartic acid and glutamic acid could be singly eliminated without deleterious effects from the diet of Aphelenchoides sp. but eliminating both together resulted in decreased reproduction. However, phenylalanine-tyrosine, threonine, lysine, and leucine-isoleucine were found to be absolute requirements by the deletion method but since they all contained some radioactivity, these amino acids were classified as limited dietary requirements by the labeling method.