cssi/SciSciGPT-SciSciNet huggingface dataset:
Thrombolysis (tissue plasminogen activator) in stroke: a medicolegal quagmire.

Background and Purpose— Despite the success of the 1995 National Institutes of Neurological Disorders and Stroke (NINDS) study using IV recombinant tissue plasminogen activator (tPA) within 3 hours in acute stroke and its subsequent FDA approval, there has been a reluctance to use tPA because of safety and efficacy issues with high incidence of intracerebral hemorrhage, and protocol violations. Summary of Review— The following cases will illustrate the increased number of malpractice lawsuits generated by the controversy of “standard of care” and illustrate and educate clinicians regarding specific issues and how to avoid: (A) Failure to use tPA (loss of chance) or to transfer, Reed versus Granbury Hospital (Texas): acute stroke victim taken to local hospital with tPA available only for cardiology. Wife subsequently transferred patient to nearby stroke center but no tPA given. Defendant verdict; (B) Stroke misdiagnosis (failure to diagnose, loss of chance), Mei versus Kaiser Permanente South (San Francisc...
Superior Labrum-Biceps Tendon Complex Lesions of the Shoulder

The detachment of the superior labrum from anterior to posterior has previously been reported. This lesion has been classified into four types. It was our impression that not all superior labrum abnormalities fit into such a classification system and that the mechanism of injury was distinctly different. During a 5-year period, 84 of 712 (11.8%) patients had significant labral abnormalities; 52 of 84 patients (6.2%) had lesions that fit within the clas sification system (Type II, 55%; III 4%; IV, 4%), but 32 of 84 patients (38%) had significant findings that could not be classified. These unclassifiable lesions fit into three distinct categories. Two of three patients de scribed a traction injury to the shoulder. Only 8% sus tained a fall on an outstretched arm; 75% had a pre operative diagnosis of impingement based on consistent history and provocative testing; however, when examined under anesthesia, 43% of the shoul ders were considered to have increased humeral head translation when compared with the ...
SAMHT — Suicidal Avatars for Mental Health Training

Psychosocial assessments and treatments are effective for a range of psychological problems. One particular area of concern is youth suicide. This paper reports on the SAMHT intelligent tutoring system, which provides youth suicide risk assessment training. SAMHT’s interactive avatar interface is based on an intelligent backend, and provides a believable interaction that is effective for training mental health professionals.
Measurement noise 100 times lower than the quantum-projection limit using entangled atoms

Quantum metrology uses quantum entanglement--correlations in the properties of microscopic systems--to improve the statistical precision of physical measurements. When measuring a signal, such as the phase shift of a light beam or an atomic state, a prominent limitation to achievable precision arises from the noise associated with the counting of uncorrelated probe particles. This noise, commonly referred to as shot noise or projection noise, gives rise to the standard quantum limit (SQL) to phase resolution. However, it can be mitigated down to the fundamental Heisenberg limit by entangling the probe particles. Despite considerable experimental progress in a variety of physical systems, a question that persists is whether these methods can achieve performance levels that compare favourably with optimized conventional (non-entangled) systems. Here we demonstrate an approach that achieves unprecedented levels of metrological improvement using half a million (87)Rb atoms in their 'clock' states. The ensemble is 20.1 ± 0.3 decibels (100-fold) spin-squeezed via an optical-cavity-based measurement. We directly resolve small microwave-induced rotations 18.5 ± 0.3 decibels (70-fold) beyond the SQL. The single-shot phase resolution of 147 microradians achieved by the apparatus is better than that achieved by the best engineered cold atom sensors despite lower atom numbers. We infer entanglement of more than 680 ± 35 particles in the atomic ensemble. Applications include atomic clocks, inertial sensors, and fundamental physics experiments such as tests of general relativity or searches for electron electric dipole moment. To this end, we demonstrate an atomic clock measurement with a quantum enhancement of 10.5 ± 0.3 decibels (11-fold), limited by the phase noise of our microwave source.
Effect Sizes and Primary Outcomes in Large-Budget, Cardiovascular-Related Behavioral Randomized Controlled Trials Funded by NIH Since 1980.

We reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes. We identified large-budget grants (>$500,000/year) funded by NIH (National Heart Lung and Blood Institute (NHLBI) or National Institute of Diabetes & Digestive and Kidney Diseases (NIDDK)) for cardiovascular disease (dates January 1, 1980 to December 31, 2012). Among 106 grants that potentially met inclusion criteria, 20 studies were not published and 48 publications were excluded, leaving 38 publications for analysis. ClinicalTrials.gov abstracts were used to determine whether outcome measures had been pre-specified. Three fourths of trials were registered in ClinicalTrials.gov and all published pre-specified outcomes. Twenty-six trials reported a behavioral outcome with 81 % reporting significant improvements for the target behavior. Thirty-two trials reported a physiological outcome. All were objectively measured, and 81 % reported significant benefit. Seventeen trials reported morbidity outcomes, and seven reported a significant benefit. Nine trials assessed mortality, and all were null for this outcome. Behavioral trials complied with trial registration standards. Most reported a physiological benefit, but few documented morbidity or mortality benefits.
A growing importance of large fires in conterminous United States during 1984-2012.

Fire frequency, extent, and size exhibit a strong linkage with climate conditions and play a vital role in the climate system. Previous studies have shown that the frequency of large fires in the western United States increased significantly since the mid-1980s due to climate warming and frequent droughts. However, less work has been conducted to examine burned area and fire emissions of large fires at a national scale, and the underlying mechanisms accounting for the increases in the frequency of large fires are far from clear. In this study, we integrated remote-sensed fire perimeter and burn severity data sets into the Dynamic Land Ecosystem Model to estimate carbon emissions from large fires (i.e., fires with size larger than 1000 acres or 4.05 km2) in conterminous United States from 1984 to 2012. The results show that average area burned by large fires was 1.44 × 104 km2 yr−1 and carbon emissions from large fires were 17.65 Tg C yr−1 during the study period. According to the Mann-Kendall trend test, annual burned area and pyrogenic carbon emissions presented significant upward trends at the rates of 810 km2 yr−1 and 0.87 Tg C yr−1, respectively. Characteristic fire size (fire size with the largest contribution to the total burned area) in the period of 2004–2012 increased by 176.1% compared to the period of 1984–1993. We further found that the larger fires were associated with higher burn severity and occurred more frequently in the warmer and drier conditions. This finding implies that the continued warming and drying trends in the 21st century would enhance the total burned area and fire emissions due to the contributions of larger and more severe wildfires.
Evaluation of enzyme immunoassay for anti-HBc IgM in the diagnosis of acute hepatitis B virus infection.

Corzyme-M™ (Abbott Laboratories, North Chicago, IL), a newly introduced kit for the measurement of serum IgM antihepatitis B core antigen by enzyme immunoassay, was evaluated for the diagnosis of acute B-viral hepatitis (AVH-B). The study included 175 acute viral hepatitis patients with transient hepatitis B surface antigen (HBsAg). Sera from 160 were tested on multiple occasions until their HBsAg cleared. IgM anti-HBc was found in 171 of 175 patients (98.4%) during the acute phase. The serum samples from 42 patients with liver biopsy-proven chronic active hepatitis, type B (CAH-B), and 18 patients with persistent hepatitis, type B (PH-B), were analyzed for the presence of IgM anti-HBc, using the same technic. None of the sera from 42 patients with CAH-B and only 2 of the 18 patients with PHB had IgM anti-HBc. Thus, the measuring IgM anti-HBc using Corzyme-M kit is helpful in the diagnosis of AVH-B and in the discrimination of acute from chronic HBV infections.
Correlation of Photosynthetic Characteristics at Filling Stage with Yield and Quality of Rice in Liaoning Province

In the recent years,the rice varieties or hybrids with erect and semi-erect panicle have been planted in large scale in Liaoning Province.In this article,the correlations between photosynthetic characteristics and yield as well as quality of rice varieties with erect and semi-erect panicle at yield formation stage were demonstrated.The photosynthetic characteristics,yield,and quality traits of 27 newly bred rice varieties in Liaoning Province were studied in two years on many locations.Results showed that there existed conic relationship between photosynthetic rate and stoma conductivity as well as evaporation rate,and there existed very significant linear relationship between photosynthetic rate and intercellular CO2 concentration.The net photosynthetic rate of leaves at middle filling stage was significant positive related with yield,and stoma conductivity and evaporation rate were positively correlated with ripened grains per panicle.Regression analysis indicated that the yield increased as the photosynthetic rate promoted and these two characters presented power exponential function relation.
Effect of Prostaglandins, Nitrofurantoin, and Escherichia Coli on Response of Human Vas Deferens to Norepinephrine

Surgical specimens of human vas deferens, mounted isometrically in vitro, were tested for their reactivity to norepinephrine, the major neurohumoral control mechanism in this tissue, under a variety of conditions. There was no significant difference in reactivity (measured as amplitude and frequency of contraction) between vasa obtained under either spinal or local anesthesia. Similarly, the age of the donor (range, 20 to 79years) had no effect on either measure of reactivity. Prostaglandins A 1 (10 -7 gm/ml) and E 2 (10 -9 gm/ml), Escherichia coli (10 5 organisms/ml), and E. coli endotoxin (10 -7 gm/ml) did not affect norepinephrine responses, suggesting that the role of these compounds in problems of fertility is not related to an alteration in sperm transport through the vas. Nitrofurantoin (10 -5 gm/ml) also had no effect on reactivity to norepinephrine, providing further evidence that low sperm counts in patients taking this drug are more appropriately attributed to a direct effect on spermatogenesis than to an effect on sperm transport.
Social desirability may explain why some caregivers of overweight children report less frequent high calorie food intake.

• 209 caregivers of preschoolers attending Head Start completed measures of BMI, child food frequency and social desirability.
Texture Optimization in the Microstructure of Mg AZ31 Alloy to Encourage Twin Formation

The microstructure of materials is often described by its texture which is the orientation distribution (ODF) of the individual grains. The nature of this distribution governs the properties of the grain boundary characteristics. These grain boundary characteristics are known to drive the various deformation modes within the microstructure. For Mg3AlZn, the prevalent deformation mode is the formation of twins. It has been found that certain grain boundary misorientation angles are favorable for twin creation. This project seeks to utilize optimization methods to maximise the grain boundary misorientation distribution (GBMD) that encourages twin formation for an initial texture. The arrangement of these unit cells will be governed by the ODF given and the GBMD will be obtained from the spread of misorientation between them. The optimization problem will then be stated as having an objective function of maximising the appropriate GBMD for a given texture that encourages twin creation by allowing the texture to be changed, limited to certain orientations. Further constraints, such as ensuring that necessary planes of unit cells always intersect so there are no voids formed in the optimized microstructure, will be developed and applied as necessary. A method for finding optimum texture for a given grain boundary characteristic is explained. A microstructure is optimized for misorientation spread that promotes twinning.
Gender Identities and Socialization

Gender socialization refers to the complicated social process in which men become appropriately masculine and women become appropriately feminine. Major societal institutions such as schools, business, families, religions, governments, science, and what is considered common sense contribute to the shaping of gendered identities that reflect masculine and feminine behavior. Simultaneously, individuals take up these gendered roles out of societal compliance and the belief that biology is destiny. Critical gender scholars argue that gender socialization limits the possibilities of individuals embracing their full humanity and argue for the elimination of the gender binary and for a recognition of the continuum of human behavior and sexuality regardless of an individual's sex. Keywords: gender discourse; gender identities; gender politics; gender socialization; gender equality
CLINICAL PHARMACISTS: PRACTITIONERS WHO ARE ESSENTIAL MEMBERS OF YOUR CLINICAL CARE TEAM

SUMMARY Clinical pharmacists are specialty trained practitioners who provide direct patient care and comprehensive medication management. While the practice model is most well established in the United States, there are clinical pharmacists throughout the world who are improving the care of patients of all ages and in all areas of acute and ambulatory care. This paper reviews the training standards, expected competencies, and contributions of clinical pharmacists.
Non-necrotizing colonic granuloma induced by schistosomiasis.

Schistosomiasis is an important parasitic disease with various clinical presentations caused by trematode blood flukes. It can present with asymptomatic, chronic colonic ulcerations, strictures, or inflammatory mass causing bowel obstruction. Intestinal polyps are uncommon and induced by antigens released from the schistosome eggs that trigger a cell-mediated inflammatory response with granuloma formation involving T cells, macrophages, and necrosis. This is very relevant while evaluating chronic intermittent gastrointestinal symptoms and eosinophilia in an immigrant patient from endemic areas of schistosomiasis. Here, we describe a case of chronic intestinal schistosomiasis which was found to have schistosomiasis-induced colonic polyp with non-necrotizing granuloma. With increase in immigrant population from the endemic areas of schistosomiasis in the United States, physicians should be aware of this disease and its various manifestations. Gastroenterologist should keep this as one of the differentials for colonic polyps. Diagnosis and treatment in time prevents further progression of the disease and its complications. Keywords: schistosomiasis; colonic polyp; granuloma; parasite; immigrant (Published: 15 December 2016) Citation: Journal of Community Hospital Internal Medicine Perspectives 2016, 6 : 33114 - http://dx.doi.org/10.3402/jchimp.v6.33114
Morphology and cardiac physiology are differentially affected by temperature in developing larvae of the marine fish mahi-mahi ( Coryphaena hippurus ).

Cardiovascular performance is altered by temperature in larval fishes, but how acute versus chronic temperature exposures independently affect cardiac morphology and physiology in the growing larva is poorly understood. Consequently, we investigated the influence of water temperature on cardiac plasticity in developing mahi-mahi. Morphological (e.g. standard length, heart angle) and physiological cardiac variables (e.g. heart rate fH, stroke volume, cardiac output) were recorded under two conditions by imaging: (i) under acute temperature exposure where embryos were reared at 25°C up to 128 h post-fertilization (hpf) and then acutely exposed to 25 (rearing temperature), 27 and 30°C; and (ii) at two rearing (chronic) temperatures of 26 and 30°C and performed at 32 and 56 hpf. Chronic elevated temperature improved developmental time in mahi-mahi. Heart rates were 1.2-1.4-fold higher under exposure of elevated acute temperatures across development (Q10≥2.0). Q10 for heart rate in acute exposure was 1.8-fold higher compared to chronic exposure at 56 hpf. At same stage, stroke volume was temperature independent (Q10∼1.0). However, larvae displayed higher stroke volume later in stage. Cardiac output in developing mahi-mahi is mainly dictated by chronotropic rather than inotropic modulation, is differentially affected by temperature during development and is not linked to metabolic changes.
Stress, Sleep, and Performance on Standardized Tests: Understudied Pathways to the Achievement Gap:

Stress exposure, and subsequent biological responses to stress exposure, can negatively affect cognitive functioning and test performance. Stress exposure affects multiple biological systems, inclu...
A model-based analysis of tissue targeting efficacy of nanoparticles

Tissue targeting is a critical challenge for systemic delivery of drug nanocarriers. To overcome this challenge, major research efforts have been undertaken to design ligand-conjugated nanoparticle...
A new formal and analytical process to product modeling (ppm) method and its application to the precast concrete industry

The current standard product (data) modeling process relies on the experience and subjectivity of data modelers who use their experience to eliminate redundancies and identify omissions. As a result, product modeling becomes a social activity that involves iterative review processes of committees. This study aims to develop a new, formal method for deriving product models from data collected in process models of companies within an industry sector. The theoretical goals of this study are to provide a scientific foundation to bridge the requirements collection phase and the logical modeling phase of product modeling and to formalize the derivation and normalization of a product model from the processes it supports. To achieve these goals, a new and formal method, Georgia Tech Process to Product Modeling (GTPPM), has been proposed. GTPPM consists of two modules. The first module is called the Requirements Collection & Modeling (RCM) module. It provides semantics and a mechanism to define a process model, information items used by each activity, and information flow between activities. The logic to dynamically check the consistency of information flow within a process also has been developed. The second module is called the Logical Product Modeling (LPM) module. It integrates, decomposes, and normalizes information constructs collected from a process model into a preliminary product model. Nine design patterns are defined to resolve conflicts between information constructs (ICs) and to normalize the resultant model. These two modules have been implemented as a Microsoft Visio® add-on. The tool has been registered and is also called GTPPM ®. The method has been tested and evaluated in the precast concrete sector of the construction industry through several GTPPM modeling efforts. By using GTPPM, a complete set of information items required for product modeling for a medium or a large industry can be collected without generalizing each company's unique process into one unified high-level model. However, the use of GTPPM is not limited to product modeling. It can be deployed in several other areas including: (1) workflow management system or MIS (Management Information System) development; (2) software specification development; (3) business process re-engineering.
Precise eye detection using discriminating HOG features

We present in this paper a precise eye detection method using Discriminating Histograms of Oriented Gradients (DHOG) features. The DHOG feature extraction starts with a Principal Component Analysis (PCA) followed by a whitening transformation on the standard HOG feature space. A discriminant analysis is then performed on the reduced feature space. A set of basis vectors, based on the novel definition of the within-class and between-class scatter vectors and a new criterion vector, is defined through this analysis. The DHOG features are derived in the subspace spanned by these basis vectors. Experiments on Face Recognition Grand Challenge (FRGC) show that (i) DHOG features enhance the discriminating power of HOG features and (ii) our eye detection method outperforms existing methods.
Function-driven design of stimuli-responsive polymer composites: recent progress and challenges

Stimuli-responsive polymer composites have been extensively investigated due to their diverse structures and functional properties in response to various environmental stimuli. The past few years have witnessed a rapid expansion of design and fabrication of such composites at both the material and system levels, which opens tremendous opportunities not only for fundamental understanding of their structure–property relationships but also for exploring their applications in emerging areas such as electronics, biomedical devices, soft robotics and electromechanical engineering. A systematic understanding of the progress in the constituent materials, properties and applications of these composites is needed to guide future development. Here, we review the most recent progress (post the year 2012) in the material and structure designs of stimuli-responsive polymer composites to understand the state-of-the-art development, with a focus on photo-, electrical- and thermo-responsive composites. The advantages and disadvantages (or limitations) of different types of polymer composites are evaluated according to response-related parameters such as response time and sensitivity to stimuli. In the end, this review is concluded with challenges and perspectives for future design of better polymer composites.
Cross-Channel Contamination of PolSAR Images due to Frequency Dependence of Faraday Rotation Angle

Compensation of the Faraday rotation (FR) effect in polarimetric synthetic aperture radar (PolSAR) involves a rotation matrix, with the FR angle determined by the magnetic field, total electron content, signal frequency, and propagation direction. We analyze the conditions where the signal frequency and/or propagation direction cannot be considered constants. In other words, the rotation matrix based on the main look direction and central radar frequency may have a significant mismatch with the received signal in fast or slow time. We derive estimates for the resulting polarimetric distortions and their effect on applications such as instrument calibration in space and measurement of the aboveground biomass.
Diabetic ketoacidosis at diagnosis of type 1 diabetes and glycemic control over time: The SEARCH for diabetes in youth study

BACKGROUND The diagnosis of type 1 diabetes (T1D) in youth is often associated with diabetic ketoacidosis (DKA). We aimed to evaluate if the presence of DKA at diagnosis of T1D is associated with less favorable hemoglobin A1c (HbA1c) trajectories over time. METHODS The SEARCH for Diabetes in Youth study of 1396 youth aged <20 years with newly diagnosed T1D were followed for up to 13 (median 8 [interquartile range or IQR 6-9]) years after diagnosis. Of these, 397 (28%) had DKA (bicarbonate level < 15 mmol/L and/or pH < 7.25 (venous) or < 7.30 (arterial or capillary) or mention of DKA in medical records) at diabetes onset. Longitudinal HbA1c levels were measured at each follow-up visit (average number of HbA1c measures 3.4). A linear piecewise mixed effects model was used to analyze the effect of DKA status at diagnosis of T1D on long-term glycemic control, adjusting for age at diagnosis, diabetes duration at baseline, sex, race/ethnicity, household income, health insurance status, time-varying insulin regimen and glucose self-monitoring, study site, and baseline fasting C-peptide level. RESULTS At baseline, HbA1c levels were significantly higher in youth with T1D diagnosed in DKA vs those who were not (9.9% ± 1.5% vs 8.5% ± 1.4%, respectively). After the first year with diabetes, there was a significant difference in the rate of change in HbA1c levels by DKA status: HbA1c was 0.16% higher each year in youth with DKA compared to those without (interaction P-value<0.0001), after adjusting for aforementioned covariates. CONCLUSIONS DKA at T1D diagnosis is associated with worsening glycemic control over time, independent of demographic, socioeconomic, and treatment-related factors and baseline fasting C-peptide.
Unique osmoregulatory morphology in primitive sharks: an intermediate state between holocephalan and derived shark secretory morphology

Discovery of an unusual rectal gland in the Atlantic sixgill shark Hexanchus vitulus led us to examine the rectal glands of 31 species of sharks to study diversity in rectal-gland morphology. Twenty-four of 31 species of sharks had digitiform glands (mean width-length ratio ± SD = 0.17 ± 0.04) previously assumed to be characteristic of all elasmobranchs regardless of habitat depth or phylogenetic age. Rectal glands from the family Somniosidae were kidney bean-shaped (mean width: length ± SD = 0.46 ± 0.05); whereas those from families Echinorhinidae and Hexanchidae were lobulate (mean width: length ± SD = 0.55 ± 0.06). Rectal gland width: length were different among species with digitiform morphology and lobulate morphology (ANOVA; R2 = 0.9; df = 15, 386; 401, F = 219.24; P < 0.001). Histological and morphological characteristics of the digitiform morphology from deep-sea sharks were similar to those from shallow-water sharks. Histology of lobulate rectal glands from hexanchids were characterised by tubule bundles separated by smooth muscle around a central lumen. Additionally, we examined plasma chemistry of four species of sharks with digitiform rectal glands and two species with lobulate rectal-gland morphology to see if there were differences between morphologies. Plasma chemistry analysis showed that urea and trimethylamine N-oxide (TMAO) followed the piezolyte hypothesis, with TMAO being highest and urea being lowest in deep-sea sharks. Among electrolytes, Na+ was highest in species with lobulate rectal glands. Hexanchids and echinorhinids both have lobulate rectal glands similar to those of holocephalans, despite the more than 400 million years separating these two groups. The morphological similarities between the lobulate rectal-gland anatomy of primitive sharks and the secretory morphology of holocephalans may represent an intermediate state between Holocephali and derived shark species.
Relapsed Diffuse Large B-Cell Lymphoma after Allogeneic CAR T-Cell Therapy Successfully Treated with PD1 Inhibition

Introduction Treatment options for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) post-chimeric antigen receptor therapy (CAR-T) are limited. Here, we report the successful treatment of R/R DLBCL with programmed cell death 1 (PD1) inhibition post-allogeneic CAR-T. Case Report A previously healthy 26-year-old Caucasian man developed B-symptoms and cervical lymphadenopathy. Biopsy revealed DLBCL, activated B-cell subtype, double expressor and Ki-67 >80%. PET/CT scan revealed disease above and below the diaphragm. He achieved a partial response (PR) after R-CHOP, progressive disease (PD) after R-ICE, stable disease (SD) after R-ESHAP, and PD one month after autologous CD19-targeted CAR-T with CTL019 (CD3ζ/4-1BB). He then received R-lenalidomide (len) with radiation (24 Gy) to his mediastinal mass achieving a PR, followed by a myeloablative (Cy/TBI-12 Gy) allogeneic stem cell transplant (aSCT) from his 10/10 HLAmatched brother. He achieved 100% donor chimerism 30 days post-aSCT (D+30). Despite persistent full donor chimerism, D+60 PET/CT showed PD with confirmed relapse upon biopsy. Immunosuppression was discontinued, and ibrutinib with len was started, followed by donor lymphocyte infusion (DLI) which led to a mixed response. He then continued on ibrutinib with weekly temsirolimus and received a second DLI achieving a PR, with PD shortly thereafter. He next proceeded to allogeneic CAR-T with axicabtagene-ciloleucel (CD3ζ/CD28), complicated by grade 1 cytokine release syndrome without neurotoxicity. Three weeks post-CAR-T, he developed diplopia due to a cranial nerve palsy. Brain MRI showed new pontine T2 changes. Cerebrospinal fluid (CSF) was negative for lymphoma and infection, but notable for T-cell predominance. One month postCAR-T, PET/CT showed a complete metabolic response (CMR). Repeat brain MRI was unchanged. Two months later, he developed dizziness and intractable nausea, and repeat brain MRI showed a new lesion in the inferior cerebellar vermis, with resolution of previous pontine change. Evaluation of the CSF and peripheral blood revealed no CAR T-cell persistence, and PET/CT confirmed disease relapse in the cerebellum and mediastinum. Patient then received focal radiation (24 Gy) to his cerebellar lesion along with pembrolizumab 200 mg IV every 3 weeks, after which his neurologic symptoms resolved. MRI one day after radiation showed near-complete resolution of enhancing vermis lesion. After 3 cycles of pembrolizumab, PET/CT showed a CMR, with no active disease on brain MRI. Three months into PD1-inhibition therapy, his disease remains in CMR, without GVHD nor treatment-related toxicities. Conclusion This case illustrates the efficacy of allogeneic CAR-T after failure of autologous CAR-T and aSCT. Furthermore, PD1 inhibition can be used safely after allogeneic CAR-T, underscoring the need for prospective clinical studies.
Ammonia Molecular Beam Epitaxy of III‐Nitrides

The advances in III‐nitride semiconductor technologies over the past two decades have stimulated progress in a variety of nitride epitaxial techniques. Molecular beam epitaxy (MBE) of III‐nitrides requires the use of a gaseous precursor to provide the nitrogen anion. When diatomic nitrogen gas is used, plasma cracking of the triple bond is necessary to liberate atomic nitrogen, termed plasma‐assisted MBE (PAMBE). This chapter presents a complementary technique known as ammonia MBE (NH 3 ‐MBE). The use of ammonia gas as the precursor removes the plasma cracking requirement, as ammonia will decompose at the growth surface for most growth temperatures. NH 3 ‐MBE growth and materials characterization have been undertaken by several research groups. This chapter presents a brief overview of the growth space, materials results, and potential applications of the NH 3 ‐MBE technique.
Pharmacokinetics, Safety, and Tolerability of Tezepelumab (AMG 157) in Healthy and Atopic Dermatitis Adult Subjects.

Tezepelumab (AMG 157) is a monoclonal antibody that targets thymic stromal lymphopoietin and has shown benefits in treating asthma. We assessed the safety, tolerability, and pharmacokinetics of single-ascending and multiple-ascending doses in two randomized, double-blind, placebo-controlled phase I studies. Healthy and atopic dermatitis subjects were enrolled in the single-dose study, and healthy subjects in the multiple-dose study. Tezepelumab showed linear pharmacokinetics in both healthy and atopic dermatitis subjects. The half-life after a subcutaneous or intravenous administration ranged from 19.9 to 25.7 days. After multiple doses, the mean area under the curve accumulation ratio was 1.82, 1.64, and 1.59 for the 35 mg, 105 mg, and 210 mg monthly subcutaneous doses, respectively. The mean maximum serum concentration (Cmax ) accumulation ratio was 1.59, 2.84, and 6.74 for the 210 mg dose given every 28, 14, and 7 days, respectively. Tezepelumab was well tolerated in both studies with no evidence of immunogenicity.
Surface Plasmon Resonant Gold-Palladium Bimetallic Nanoparticles for Promoting Catalytic Oxidation

Colloidal gold-palladium (Au-Pd) bimetallic nanoparticles were used as catalysts to study the ethanol (EtOH) photo-oxidation cycle, with an emphasis towards driving carbon-carbon (C-C) bond cleavage at low temperatures. Au-Pd bimetallic alloy and core-shell nanoparticles were prepared to synergistically couple a plasmonic absorber (Au) with a catalytic metal (Pd) with composite optical and catalytic properties tailored towards promoting photocatalytic oxidation. Catalysts utilizing metals that exhibit localized surface plasmon resonance (SPR) can be harnessed for light-driven enhancement for small molecule oxidation via augmented photocarrier generation/separation and photothermal conversion. The coupling of Au to Pd in an alloy or core-shell nanostructure maintains SPR-induced charge separation, mitigates the poisoning effects on Pd, and allows for improved EtOH oxidation. The Au-Pd nanoparticles were coupled to semiconducting titanium dioxide photocatalysts to probe their effects on plasmonically-assisted photocatalytic oxidation of EtOH. Complete oxidation of EtOH to CO2 under solar simulated-light irradiation was confirmed by monitoring the yield of gaseous products. Bimetallics provide a pathway for driving desired photocatalytic and photoelectrochemical reactions with superior catalytic activity and selectivity.
Climate change curricula for adult audiences in agriculture and forestry: A review

Agricultural and forestry advisers and other technical service providers play an important role in supporting farmers and foresters to adapt to climate change. However, not all agricultural and for...
The Star Emc Project

The STAR Electromagnetic Calorimeter (STAR EMC) is a lead-scintillator sampling calorimeter covering -1 ≤ η ≤ 1 and 0 ≤ O ≤ 2π with a segmentation of (⌽ η, ⌽O) = (0.05, 0.05). The STAR EMC also contains a shower maximum detector at 5 X o with an effective segmentation of (⌽η, ⌽O) = (0.007, 0.007). The STAR EMC will allow STAR to study phenomena in Au-Au collisions at RHIC such as disoriented chiral condensates, jet quenching, and high Pt particles spectra. In p-p and p-Au collisions the STAR EMC will enable the study phenomena such as the gluon structure function of the proton and gluon shadowing. The STAR EMC is essential for the spin physics program in STAR.
Line selection by injection in a TEA CO2

Several potential applications of high energy pulsed CO2 lasers, such as optical pumping of other laser transitions and atmospheric spectroscopic measurements, require a monochromatic pulse whose frequency can be selected from a number of possible laser lines or tuned quickly from line to line. For example, in the measurement of trace atmospheric constituents using the differential absorption lidar (DIAL) technique, rapid switching from one wavelength to another is desirable when turbulence-induced fluctuations affect the pulse-to-pulse variability.
Multi-level Drivers of Disparities in Hispanic Cesarean Delivery Rates in US-Mexico Border States

Hispanic women living along the US-Mexico border have higher cesarean delivery rates than non-Hispanic white women, African American women, and other Hispanic women in the USA. Their rates also exceed those of other Hispanic women in states that border Mexico and non-Hispanic white women along the border. Our objective was to determine the causes of the disparities in border Hispanic cesarean rates. Using the 2015 birth certificate file and other sources, we performed a twofold Oaxaca-Blinder decomposition analysis of the disparities in low-risk primary and repeat cesarean rates between Hispanic and non-Hispanic white women in the US-Mexico border counties and Hispanic women residing in nonborder counties of border states. Rates of low-risk primary cesarean among border Hispanic, nonborder Hispanic, and border non-Hispanic white women were 21.1%, 15.0%, and 16.5%, respectively. Higher Hispanic concentration in county of residence, a larger proportion of for-profit hospital beds, and greater poverty accounted for 24.7%, 22.1%, and 11.1% of the border-nonborder Hispanic difference, respectively. No other variable explained more than 5% of the difference. Higher Hispanic concentration, more for-profit beds, less attendance by an MD, higher BMI, and greater poverty explained 60.6%, 42.4%, 42.4%, 27.4%, and 21.3%, respectively, of the Hispanic-non-Hispanic white difference. Hispanic concentration and for-profit beds were also important explanatory variables for low-risk repeat cesareans. Efforts to address potentially unnecessary cesareans among Hispanic women on the border should recognize that community demographic and health delivery system characteristics are more influential than maternal medical risk factors.
Choroid Plexus Tumors

Choroid plexus tumors are rare tumors, predominantly found in pediatric patients. Lower grade tumors histologically resemble native choroid plexus while higher grade lesions are progressively more disordered and less differentiated. They are commonly associated with hydrocephalus and usually present with symptoms of that condition. Complete resection is typically curative in the case of low grade lesions. Higher grade lesions may be treated with adjuvant chemotherapy or radiotherapy. The hydrocephalus often resolves but in some cases may persist after resection and may require additional treatment.
Ulnar (Postaxial) Polydactyly

This condition is also known as ulnar polydactyly, postaxial polydactyly, fifth-finger duplication, postaxial hexadactyly and ulnar duplication. It presents as a sixth digit adjacent to the small finger. The category of polydactyly is the most common of all congenital differences of the upper extremity, and extra digits or a part of a digit on the ulnar side of the hand is the most frequent site. This is true in all large hand registries.
Is there Still a Time Window in the Treatment of Acute Stroke

It has become evident that strict time-based criteria are not optimal in selecting patients for acute stroke intervention, leaving the majority of patients untreated due to missing universal time-based criteria. We discuss the pathophysiologic basis for a shift of focus from time to the imaging evidence of salvageable tissue, as well as clinical and imaging tools. There is strong evidence for the benefit of thrombectomy in patients with a sustained salvageable tissue presenting within 24 h. Although evidence of benefit is limited in patients presenting longer than 24 h, those patients will have a poor functional outcome if untreated. MRI-based approaches to choose patients for thrombolytic therapy later than 4.5 h are relatively safe and modestly effective. Defining a patient-based therapeutic window to replace strict time windows and therefore refining patient exclusion and inclusion criteria is possible through understanding pathophysiology of acute ischemic stroke in individual patients.
Spatial Release From Masking in Bimodal and Bilateral Pediatric Cochlear Implant Recipients

Purpose Traditional clinical measures of cochlear implant (CI) recipient performance may not fully evaluate the benefit of bimodal listening (hearing aid contralateral to a CI). The clinical assessment of spatial release from masking (SRM) may be a sensitive measure of the benefit of listening with bimodal stimulation. This study compared the SRM of pediatric bimodal and bilateral CI listeners using a clinically feasible method, and investigated variables that may contribute to speech recognition performance with spatially separated maskers. Method Forty pediatric bimodal (N = 20) and bilateral CI (N = 20) participants were assessed in their best aided listening condition on sentence recognition in a four-talker masker. Testing was completed with target and masker colocated at 0° azimuth, and with the masker directed at 90° to either ear. SRM was calculated as the difference in performance between the colocated and each 90° condition. A two-way mixed-methods analysis of variance was used to compare performance between groups in the three masker conditions. Multiple regression analyses were conducted to investigate potential predictors for SRM asymmetry including hearing history, unaided thresholds, word recognition, duration of device use, and acoustic bandwidth. Results Both groups demonstrated SRM, with significantly better recognition in each 90° condition as compared to the colocated condition. The groups did not differ significantly in SRM. The multiple regression analyses did not reveal any significant predictors of SRM asymmetry. Conclusions Bimodal and bilateral CI listeners demonstrated similar amounts of SRM. While no specific variables predicted SRM asymmetry in bimodal listeners, pediatric bimodal and bilateral CI recipients should expect similar amounts of SRM regardless of the side of the masker. SRM asymmetry in pediatric bimodal listeners may signal a need for consideration of a second CI.
A mixed-methods approach to comparing perceptions of cancer patients' and cancer care providers' religious and spiritual beliefs, behaviours, and attitudes.

OBJECTIVES To compare the perceptions of cancer patients' and cancer care providers' religious and spiritual (RS 64.7%), while a smaller subset included physicians (n = 61; 17.9%) and "other" providers (n = 59; 17.4%). There was no difference between patients and providers in relation to R&S identity (p = 0.49) or behaviour (p = 0.28). Providers more frequently indicated that patients should receive R&S resources in the hospital (n = 281, 89.7% vs. n = 111, 49.6%, p < 0.001). For resource type, patients most frequently endorsed written resources (n = 93, 83.8%) while providers endorsed relational resources (n = 281, 97.9%). CONCLUSION Aligning patient and provider expectations of spiritual care will contribute to provision of optimal patient-centred cancer care.
Progressive Segment Routing for Vehicular Named Data Networks

Adopting the Named Data Networking (NDN) architecture for Vehicular Ad Hoc Networks (VANETs) can help improve the communication among vehicles because of the data-centric nature of NDN. Routing in vehicular NDNs is still a challenge because of high mobility and intermittent connections. This paper proposes a new progressive segment routing approach that takes into consideration how vehicles are distributed among different roads, with the goal of choosing well-traveled roads over less-traveled roads to reduce the failure rate of packet delivery. A novel criterion for determining progress of routing is designed to guarantee that the destination will be reached even if a temporary loop may be formed in the path. Simulation results demonstrate that the proposed progressive segment routing algorithm can achieve better performance than existing algorithms for vehicular NDNs.
Preparing students for the profession: examining power within social work

Social work educators are tasked with students to incorporate into practice the skills of engaging diversity and difference, advancing human rights and challenging social injustice. Students are as...
An Impedance Control Network based Single-Stage Universal-Input Isolated AC-DC Converter Utilizing Reconfigurable Inverters

This paper presents a high-power-density single-stage isolated resonant ac-dc converter based on the impedance control network (ICN) with reconfigurable inverters. The ICN converter with phase-shift control can perform power factor correction and output voltage regulation while maintaining zero voltage switching (ZVS) and near zero current switching (ZCS) of its inverter transistors across a wide range of input voltage and output power. The proposed reconfigurable-inverter design allows the inverters of this converter to operate in parallel at low line and in a stacked fashion at high line, which further enhances performance by simultaneously reducing the peak inverter transistor voltage stress, the resonant inductance requirement and the transformer turns ratio by a factor of two. A 330-W, universal-input-to-20V output reconfigurable-inverter based ICN ac-dc converter prototype is designed, built, and tested. This GaN-based prototype achieves a power density of 44.5 W/in3 and peak efficiencies of 94% and 93.8% at low-line (120 V rms , 60 Hz) and high-line input (230 V rms , 50 Hz), respectively.
What Makes Families Healthy? Examining Correlates of Family Health in a Nationally Representative Sample of Adults in the United States:

Conceptually, family health is crucial for individual health across the lifespan, yet previous research has lacked a validated family health measure. The current study examines the relationships be...
Empiricism and the Foundations of Psychology

Intended for philosophically minded psychologists and psychologically minded philosophers, this book identifies the ways that psychology has hobbled itself by adhering too strictly to empiricism, this being the doctrine that all knowledge is observation-based. In the first part of this two-part work, we show that empiricism is false. In the second part, we identify the psychology-relevant consequences of this fact. Five of these are of special importance: (i) Whereas some psychopathologies (e.g. obsessive-compulsive disorder) corrupt the activity mediated by one’s psychological architecture, others (e.g. sociopathy) corrupt that architecture itself. (ii) The basic tenets of psychoanalysis are coherent. (iii) All propositional attitudes are beliefs. (iv) Selves are minds that self-evaluate. And: (v) It is by giving our thoughts a perceptible form that we enable ourselves to evaluate them, and it is by expressing ourselves in language and art that we give our thoughts a perceptible form. (Series A)
ASSAY OF CHOLESTEROL AUTOXIDATION

Publisher Summary The autoxidation of cholesterol (cholest-5-en-3β-ol) by molecular oxygen ( 3 O 2 ) leads to the formation of a large number of oxysterols of diverse chemistry, biological activities, and biomedical implications. Product analysis by simple one-dimensional thin-layer chromatography (TLC), with high-performance liquid chromatography (HPLC) as adjunct, provides a reliable means to determine autoxidation. In special cases where oxysterol identifications beyond TLC characterizations are crucial, additional HPLC or gas chromatography analyses of trimethylsilyl ethers coupled with mass spectrometry are useful for definitive identifications. Adventitious autoxidation occurring during sample manipulations and analysis must be controlled lest there be misleading results. Sample protection from air, light, and heat is essential. Immediate sample processing by solvent extraction or freeze-drying is recommended, as oxysterols form in frozen tissues stored in contact with air. Operations under an inert atmosphere or vacuum with added antioxidant and with isotopic cholesterol added to assess the extent of adventitious autoxidation during operations are recommended for quantitation. Quantitation of oxysterols is generally achieved by additional chromatography (HPLC or gas chromatography of trimethylsilyl ethers) following preliminary separation of oxysterols from massive amounts of cholesterol.