cssi/SciSciGPT-SciSciNet huggingface dataset:
Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior

Embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination promotes an epigenetic reprogramming of the male germ-line that is associated with transgenerational adult onset disease states. Further analysis of this transgenerational phenotype on the brain demonstrated reproducible changes in the brain transcriptome three generations (F3) removed from the exposure. The transgenerational alterations in the male and female brain transcriptomes were distinct. In the males, the expression of 92 genes in the hippocampus and 276 genes in the amygdala were transgenerationally altered. In the females, the expression of 1,301 genes in the hippocampus and 172 genes in the amygdala were transgenerationally altered. Analysis of specific gene sets demonstrated that several brain signaling pathways were influenced including those involved in axon guidance and long-term potentiation. An investigation of behavior demonstrated that the vinclozolin F3 generation males had a decrease in anxiety-like behavior, while the females had an increase in anxiety-like behavior. These observations demonstrate that an embryonic exposure to an environmental compound appears to promote a reprogramming of brain development that correlates with transgenerational sex-specific alterations in the brain transcriptomes and behavior. Observations are discussed in regards to environmental and transgenerational influences on the etiology of brain disease.
Pruning of Meadowsweet and Steeplebush

ADDITIONAL INDEX WORDS. Spiraea alba, Spiraea tomentosa, hardhack, native plants, growth, flowering SUMMARY. Two native shrubs, meadowsweet (Spiraea alba) and steeplebush (Spiraea tomentosa), are currently grown for use in habitat restoration. Pruning could improve their form and encourage use in more formal gardens. Two seedling populations of each species were grown in the field or in containers outdoors. In Mar. 2009, plants were pruned to 3 or 15 cm or were left unpruned. By midsummer, there was no effect of pruning on plant height in field-grown plants. However, pruning did eliminate lateral growth in field plants and, therefore, improvedoverallformoftheplants.Meadowsweet prunedto3cmhad abouthalfas many inflorescences as did meadowsweet pruned to 15 cm, with unpruned plants producing an intermediate number of inflorescences. Pruning container plants to 3 cm resulted in plants that were about half the height of unpruned plants, and total biomass was greatly reduced. In general, plants that were pruned had fewer inflorescences, although the total number of inflorescences in all plants was small. Pruning resulted in lower quality plant form in container plants. Species and seed sourceswithinspecies respondedsimilarlytopruning.Basedon thedatacollected in this study, newly planted meadowsweet and steeplebush should be pruned to achieve good form in the first year. Despite the sometimes leggy growth habit in containers, these species should not be pruned before growing out in the spring, or maximum growth and good form will not be attained.
Poverty and Mental Health

An overview of the relations between monetary poverty and mental health is provided in this article. Children and adults who experience poverty are at an increased risk for mental health disorders, including depression, anxiety, and substance abuse. In particular, this article highlights the critical role that stress plays in generating these mental health risks for individuals experiencing poverty and incorporates biological components of this process, such as allostatic load. In addition, the issue of how mental health problems serve as barriers to employment and stable income is discussed. In conclusion, the disparities in options for mental health treatment between individuals in poverty and their nonpoor counterparts are summarized and the current federal programs designed to increase access to mental health treatment are highlighted.
Viral myocarditis: is infection of the heart required?

Coxsackieviral myocarditis continues to be a disease that is difficult to diagnose and treat in spite of decades of research in both patients and mice. The prominence of the inflammatory response combined with the challenge in definitively identifying viral infection within the myocardium in a given
Exercise-related changes in between-network connectivity in overweight/obese adults

Understanding how exercise affects communication across the brain in overweight/obese individuals may provide insight into mechanisms of weight loss and maintenance. In the current study, we examined the effects of a 6-month exercise program in 11 overweight/obese individuals (mean BMI: 33.6±1.4mg/kg(2); mean age: 38.2±3.2years) on integrative brain "hubs," which are areas with high levels of connectivity to multiple large-scale networks thought to play an important role in multimodal integration among brain regions. These integrative hubs were identified with a recently developed between-network connectivity (BNC) metric, using functional magnetic resonance imaging (fMRI). BNC utilizes a multiple regression analysis approach to assess relationships between the time series of large-scale functionally-connected brain networks (identified using independent components analysis) and the time series of each individual voxel in the brain. This approach identifies brain regions with high between-network interaction, i.e., areas with high levels of connectivity to many large-scale networks. Changes in BNC following exercise were determined using paired t-tests, with results considered significant at a whole-brain level if they exceeded a voxel-wise threshold of p<0.01 and cluster-level family-wise error (FWE) correction for multiple comparisons of p<0.05. Following the intervention, BNC in the posterior cingulate cortex (PCC) was significantly reduced (p<0.001). The changes driving the observed effects were explored using Granger causality, finding significant reductions in both outgoing causal flow from the PCC to a number of networks (p<0.05; language network, visual network, sensorimotor network, left executive control network, basal ganglia network, posterior default mode network), in addition to reductions in ingoing causal flow to the PCC from a number of networks (p<0.05; ventral default mode network, language network, sensorimotor network, basal ganglia network). Change in BNC was related to changes in aerobic fitness level (VO2 max; p=0.008) and perceived hunger (Three Factor Eating Questionnaire; p=0.040). Overall, the impact of exercise on communication between large-scale networks may contribute to individual responsivity to exercise.
Insect Parasites of the European Corn Borer Ostrinia nubilalis in Nebraska from 1948–1976

Five exotic parasite species of the European corn borer, Ostrinia nubilalis (Hbn.), were introduced into Nebraska in 1948–1950. Only 3 species became established: a tachinid, Lydella thompsoni Herting (= grissescens Robineau-Desvoidy of Authors); an ichneumonid, Eriborus terebrans (Gravenhorst) (= Horogenes punctorius (Roman)); and a eulophid, Sympiesis viridula (Thomson) (= Eulophus viridulus ). Population trends for L. thompsoni and E. terebrans are reported for 2 counties for the years 1957–1971. No evidence has been found of L. thompsoni since 1965 but E. terebrans was widespread and present in low numbers in 1975 and 1976.
Betriebsführung und Instandhaltung von Wasser- und Wärmekraftwerken vor dem Hintergrund der Veränderungen im Europäischen Elektrizitätsmarkt

Am Beispiel des Kraftwerksparks der Verbund-Elektrizitatserzeugungs-Ges.m.b.H. (VEG), die seit dem 1. Janner 1997 alle im Eigentum der Sondergesellschaften Donaukraft, Draukraft, Tauernkraft und Verbundkraft befindlichen Kraftwerksanlagen im Auftrag der Eigentumer fuhrt und instandhalt, wird dargelegt, wie sich die zugehorigen Aufgaben auf Grund der gravierenden Veranderungen im europaischen Elektrizitatsmarkt gewandelt haben [1]. Mit einer fur die VEG entwickelten Instandhaltungsstrategie und einer der neuen Marktsituation angepasten Betriebsfuhrung kann der Personalstand in den 46 Kraftwerksanlagen mit einer installierten Turbinenleistung von insgesamt rund 6 300 MW und einer mittleren Jahresproduktion von mehr als 20 TWh vom Ausgangsstand mit 1 744 Mitarbeiterjahren (MJ) am 1. Janner 1997 auf voraussichtlich 1 090 MJ gesenkt werden. Auch der Einsatz des an den Hauptverwaltungsstandorten fur die Kraftwerke tatigen technischen und kaufmannischen Fachpersonals wird im gleichen Zeitraum von 570 DJ auf 360 MJ reduziert werden.
Effects of Interference Competition on the Foraging Activity of Tropical Roseate Terns

Although difficult to detect, interference competition among foraging birds may affect the fitness of an inferior competitor by lowering foraging success. We studied foraging flocks of Roseate Terns (Sterna dougallii) at Culebra, Puerto Rico, in 1990 to examine the effects of small and large monospecific and mixed-species flocks on the foraging success and behavior of this threatened species. Roseate Terns mostly foraged in small flocks with Brown Noddies (Anous stolidus). The frequency of foraging attempts in Roseate Terns decreased with increasing size of mixed-species flocks, primarily due to passive interference by Brown Noddies, which foraged just over the water surface and limited the area available to Roseate Terns. The size of monospecific Roseate Tern flocks had no effect on foraging attempt frequency. Roseate Terns also aborted more feeding dives and foraged more by dipping when in flocks with noddies, relative to flocks of only conspecifics. Proportionally fewer Roseate Terns than expected foraged in large, mixed-species flocks (>8 birds), suggesting that they preferentially avoid large flocks that result in lower foraging success. Although Brown Noddies caused a reduction in Roseate Tern foraging attempt frequencies and an increase in aborted dives, we were unable to detect a negative effect on adult survival or reproductive success of this population.
Renal metabolism of citrate.

Our studies on renal handling of citrate have shown that: (1) citrate enters renal tubular cells from luminal fluid (reabsorption) and peritubular blood; (2) reabsorption becomes maximal, i.e., Tm-limited, at filtered loads 7 to 8 times the normal; (3) administration of malate stimulates net renal production of citrate, leading to release into urine (net secretion) and into peritubular blood; (4) acute metabolic alkalosis, induced while plasma citrate levels are above normal, depressess net citrate reabsorption, stimulates citrate release into peritubular blood and abolishes overall renal uptake of citrate; (5) essentially all citrate extracted by the kidney is converted to CO2 at endogenous circulating levels. This contribution is 15 per cent of the total renal CO2 production and is independent of chronic alterations in acid-base balance.
Remarks on pumping units in oil fields

The working principle of an extractor is presented in the paper.The casings in oil well are regarded as a pump cylinder and an extractor with sliding sealing is regarded as a pump.Pulled by steel rope,the extractor pumps oil in discarding wells and low producing wells.Immovable pumping unit,trailer-mounted pumping unit and railcar-mounted pumping unit are developed in recent years.The main structures,dynamical transmission and characteristics of these machines are also introduced in the paper.
Teachers and Sanitation Promotion: An Assessment of Community-Led Total Sanitation in Ethiopia

Community-led total sanitation (CLTS) is a participatory approach to addressing open defecation that has demonstrated success in previous studies, yet there is no research on how implementation arrangements and context change effectiveness. We used a quasi-experimental study design to compare two interventions in Ethiopia: conventional CLTS in which health workers and local leaders provided facilitation and an alternative approach in which teachers provided facilitation. In 2012, Plan International Ethiopia trained teachers from 111 villages and health workers and leaders from 54 villages in CLTS facilitation. The trained facilitators then implemented CLTS in their respective villages for a year. Latrine ownership, use, and quality were measured with household surveys. Differences between interventions were explored using surveys and interviews. The decrease in open defecation associated with teacher-facilitated CLTS was 8.2 percentage points smaller than for conventional CLTS (p = 0.048). Teachers had co...
Foundations of Electromagnetic Theory

In this chapter, we introduce the basic equations governing the electromagnetic field in inhomogeneous conductive media, and review the basic physical laws important in developing electromagnetic inverse theory. We also consider the fundamental theorems related to electromagnetic energy flow, including energy inequality and Poynting’s theorem in the frequency and time domains. The Poynting’s theorem provides a basis for proving the uniqueness theorems for the boundary-value electromagnetic problem. We also introduce a concept of electromagnetic Green’s tensors, which provide a solution of Maxwell’s equations for an arbitrary allocation of electric current sources. Finally, the chapter concludes with the introduction of Lorentz lemma and reciprocity relations.
Creating content marketing for libraries

Content marketing can be a powerful tool for marketing the services of academic and health sciences libraries. Competing for the attention of busy students and faculty, the library must develop its own channels of engagement, which makes content-driven activities essential. A common example is resource licensing. Once a library licenses a new resource, driving or encouraging usage is a challenge. Traditional communication efforts such as email blasts are usually not sufficient as busy users tend to use resources that they are already familiar with. Creating content-driven marketing around the availability of library resources is an innovative way to create long-term engagement with users and reinforce the availability of new resources. Yet creating content for marketing is not an easy task, especially when librarians are already busy with managing their libraries' daily operations and a variety of projects.
Integer comparisons across the grades: Students’ justifications and ways of reasoning

Abstract This study is an investigation of students’ reasoning about integer comparisons—a topic that is often counterintuitive for students because negative numbers of smaller absolute value are considered greater (e.g., −5 > − 6). We posed integer-comparison tasks to 40 students each in Grades 2, 4, and 7, as well as to 11th graders on a successful mathematics track. We coded for correctness and for students’ justifications, which we categorized in terms of 3 ways of reasoning: magnitude-based, order-based, and developmental/other. The 7th graders used order-based reasoning more often than did the younger students, and it more often led to correct answers; however, the college-track 11th graders, who responded correctly to almost every problem, used a more balanced distribution of order- and magnitude-based reasoning. We present a framework for students’ ways of reasoning about integer comparisons, report performance trends, rank integer-comparison tasks by relative difficulty, and discuss implications for integer instruction.
The Not So Evil Within? Agency in Video Game Choice and the Impact of Violent Content

Background. The degree to which violent video games do, or do not contribute to aggressive behavior and hostility remains controversial in the scientific community, with scholars not yet having come to a consensus about effects. Recent studies have examined whether other issues such as frustration or competition might explain some video game influences that were previously thought to be due to violent content. Aim. The current study examines whether player agency in determining choice of game played influences aggressive outcomes. Methods. Young adult players were randomized either to play a violent game, a non-violent game, or to be given the choice between several violent and non-violent games. Players were examined for subsequent aggressive behavior using the ice water task as well as for stress levels and hostility. Results. Game condition did not influence hostility, stress, or aggressive behavior, whether with randomized or chosen games. Conclusion. The present study provided no evidence that violent video games contribute to aggressive behavior. Lack of influence for agency in game choice can be understood given the lack of any aggression effect for violent game exposure.
Response to “An exceptionally preserved 110 million years old praying mantis provides new insights into the predatory behaviour of early mantodeans”

Hornig, Haug & Haug (2017) published a description of a new specimen of Santanmantis axelrodi MB.I.2068, an extinct species of praying mantis from the Crato Formation of Brazil. According to Hornig, Haug & Haug (2017), the discovery of this new specimen brought with it implications for praying mantis character evolution and predatory behavior; it is with these lines of reasoning that we find fault. More specifically, we point to four flawed assumptions in their study that led to their unsubstantiated conclusion that S. axelrodi employed their mesothoracic legs in prey capture.
Dialogue-Learning Correlations in Spoken Dialogue Tutoring

We examine correlations between dialogue characteristics and learning in two corpora of spoken tutoring dialogues: a human-human corpus and a human-computer corpus, both of which have been manually annotated with dialogue acts relative to the tutoring domain. The results from our human-computer corpus show that the presence of student utterances that display reasoning, as well as the presence of reasoning questions asked by the computer tutor, both positively correlate with learning. The results from our human-human corpus show that the introduction of a new concept into the dialogue by students positively correlates with learning, but student attempts at deeper reasoning do not, and the human tutor's attempts to direct the dialogue negatively correlate with learning.
A colonial history of the higher education present: rethinking land-grant institutions through processes of accumulation and relations of conquest

This conceptual paper examines the colonial conditions of possibility for a formative moment of US public higher education, the Morrill Act of 1862, and considers how these conditions continue to s...
Postnatal College Trajectories: When and Under What Circumstances Do Mothers Enroll?

Background/ContextIn light of increasingly common, non-traditional pathways to college enrollment and potential importance of post-secondary education for family wellbeing, this article examines ma...
Statistics and Baseball Fandom: Sabermetric Infrastructure of Expertise:

Baseball is a rich melange of tradition, spectatorship, evaluation, and fandom. Statistical fandom is presented as a cultural infrastructure, which influences how all fans perceive the game includi...
The Innocence Project

The Innocence Project is one of more than 65 pro bono organizations throughout the world that have been created since 1992 – now affiliated through the Innocence Network – which work to exonerate wrongly convicted individuals serving sentences for serious crimes they did not commit. The Innocence Project itself handles only cases in which new DNA evidence can prove innocence. Other members of the Innocence Network also utilize other types of new evidence to prove innocence. Together, the projects, through the Innocence Network, also utilize the lessons learned from false convictions to advocate for reforms designed to minimize error in the criminal justice system.
Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells

Purpose To investigate the impact of ascorbate, via DNA hydroxymethylation, on VEGF expression in retinal pigment epithelial (RPE) cells. Methods Dot-blot and hydroxymethylated DNA immunoprecipitation sequencing were applied to evaluate the impact of ascorbate on DNA hydroxymethylation in ARPE-19 cells. RNA sequencing (RNA-seq) was carried out to analyze the transcriptome. Quantitative RT-PCR and ELISA were conducted to examine the transcription and secretion of VEGF from cultured cells. Primary human fetal RPE cells and RPE-J cells were used to verify the effect of ascorbate on VEGF expression. ELISA was used to measure VEGF in the vitreous humor of Gulo-/- mice, which, like humans, cannot synthesize ascorbate de novo. Results Treatment with ascorbate (50 μM) promoted 5-hydroxymethycytosine (5hmC) generation and changed the genome-wide profiles of 5hmC in ARPE-19 cells. Ascorbate also caused a dramatic shift in the transcriptome-3186 differential transcripts, of which 69.3% are correlated with altered 5hmC in promoters or gene bodies. One of the most downregulated genes was VEGFA, which encodes the VEGF protein. The suppression of VEGF by ascorbate is independent of hypoxia-inducible factor 1-alpha (HIF-1α) but correlates with increased 5hmC in the gene body. The decreased transcription and secretion of VEGF by ascorbate were verified in primary human fetal RPE cells. Furthermore, adding ascorbate in the diet for Gulo-/- mice resulted in decreased levels of VEGF in the RPE/choroid and vitreous humor. Conclusions Ascorbate inhibits VEGF expression in RPE cells likely via DNA hydroxymethylation. Thus, ascorbate could be implicated in the prevention or treatment of diseases such as age-related macular degeneration (AMD).
U.S. College Students' Social Network Characteristics and Perceived Social Exclusion: A Comparison Between Drinkers and Nondrinkers Based on Past-Month Alcohol Use.

Objective:There is a general perception on college campuses that alcohol use is normative. However, nondrinking students account for 40% of the U.S. college population. With much of the literature ...
Yumeno Kyūsaku and the Spirit of the Local

ABSTRACTYumeno Kyūsaku (1889–1936), a leading figure in the genre of henkaku tantei shōsetsu (strange or unorthodox detective fiction), often used strange happenings and a gothic atmosphere to thrill readers. The supernatural spills over into his fictional worlds in the form of bizarre events that force his protagonists to confront the border between sanity and madness. They are tormented by voices, visions, and the inability to discern reality. Unlike many writers, Kyūsaku remained in his hometown, Fukuoka, and he regularly incorporated local events and themes into his work. This article examines how the supernatural and the local are intertwined in two of his texts to critique Japan’s course of modernization and how the tamashii – spirit or soul – of the past changes with the times.
Teaching non-FDA approved nonprescription products: Educating students about potential risks and liability

Abstract Introduction University professors who teach self-care and nonprescription products must decide which products and ingredients to recommend to students. The Food and Drug Administration (FDA) has approved many nonprescription ingredients as both safe and effective through the evidence-based FDA Over-the-Counter (OTC) Product Review or New Drug Application (NDA) processes. However, thousands of nonprescription products sold in community pharmacies are of unproven safety and/or efficacy. These include herbs, dietary supplements, homeopathic products, and essential oils. Selling products of unproven safety and/or efficacy can have serious consequences, exposing pharmacists to legal liability due to violations of the principles of implied and/or express warranties, as found in the Uniform Commercial Code. Further, the FDA defines products lacking proven safety and efficacy as health fraud, a crime aggressively pursued by both the FDA and the Federal Trade Commission. Commentary Faculty members who limit their nonprescription ingredient recommendations to those with FDA approval can justify those recommendations by weight of evidence. If the faculty member recommends ingredients that the FDA has not approved (e.g., kava), students should be taught that those ingredients pose unknown risks and lack proven benefit, and also that their labels virtually always lack doses proven to be safe, precautions, contraindications, and drug interactions. Implications Selling unproven products can lower trust in pharmacy, cause patient harm, and expose the pharmacist to legal action. These issues should be explained to students whenever unproven products are discussed or recommended.
Neurologic Immune-Related Adverse Events Associated with Immune Checkpoint Inhibition

This review highlights the spectrum of neurologic adverse events seen with use of immune checkpoint inhibitors (ICIs), their potential mechanisms, the treatments undertaken, and the clinical outcomes. The advent of ICIs has revolutionized cancer therapy. Neurologic adverse events (NAEs) are rare but clinically significant complication of ICIs. They can involve both the central and peripheral nervous system. Examples include myositis, neuropathy, encephalopathy, and myasthenia gravis. Treatment consists of holding the ICI, administration of corticosteroids, and other immunomodulatory agents as needed. The outcomes are generally favorable; however, rarely severe events can lead to significant morbidity and even mortality. Identifying and treating the range of neurologic adverse events that may potentially arise with ICIs is very important as the oncologic indications for their use continues to expand.
The Belt Road and Beyond: State-Mobilized Globalization in China: 1998–2018

From 1998 to 2018, China had three political-economic crises, resulting in bureaucratic paralysis. It was at such junctures that China's leadership launched initiatives, like the Western Development Program, that mobilized state and market actors to expedite globalization and revive economic growth. In The Belt Road and Beyond, Min Ye reevaluates the common tendency to attribute China's Belt and Road to individual leaders' strategic ambitions, using state-mobilized globalization as a comparative framework and investigative tool to understand Chinese capitalism. State-mobilized globalization has helped sustain China's high-growth economy and social-political stability, while also sparking some political backlash. In order to succeed in globalization, the author argues, China's state mobilization must readapt to global circumstances. She sheds light on the tactics China used to spring from a crisis-stricken middle economy to a formidable global power, implicating not only China, but also the world.
Subdiffusive light transport in three-dimensional subrandom arrays

We investigate light transport in three-dimensional scattering systems generated according to subrandom sequences and demonstrate subdiffusive behavior typical of wave transport in disordered systems at the critical point for metal-insulator-transitions but in a wider range of parameters. Specifically, we solve the electromagnetic multiple scattering problem using the Green's matrix spectral theory for aperiodic systems based on Halton, Sobol, and stochastic Latin hypercube sequences. By studying the Thouless number and the level-spacing statistics of the electromagnetic resonances at different scattering densities, we demonstrate that light transport in deterministic Halton and Sobol structures exhibit multifractal behavior characterized by inverse power-law scaling of level-spacing statistics across a wide range of densities of dipolar scatterers. On the other hand, this scenario is absent in the stochastic Latin hypercube array, whose behavior instead resembles standard diffusion in uniform random media. Our findings establish a connection between subdiffusion and subrandom aperiodic order and provide a strategy to design three-dimensional structures with multifractal properties over a broad spectral range.
Dynamic State Estimation-Based Protection of Distribution Systems with High Penetration of DERs

The integration of distributed energy resources (DERs) into distribution systems has brought immense changes and challenges. Fault currents can now flow bidirectionally and the levels can vary widely. As a result, correct protection operation based of legacy distribution current-based relays cannot be guaranteed. Dynamic state Estimation-Based Protection (EBP) is one of the schemes proposed to protect such active distribution network. EBP identifies internal faults while ignores external faults by checking the consistency between redundant measurements and the protection zone model, irrespectively of direction or level of fault currents. However, one issue is encountered when applying the EBP in distribution systems: the unavailability of measurements at load and DER branches in the protection zone (reduced measurement set). The influence of reduced measurements is investigated by case studies and several selected protection methods are compared with the EBP. The results show that the EBP has greater sensitivity and selectivity compared to other protection methods.
The Reception of Machado de Assis and Clarice Lispector in the United States and Beyond

O presente artigo aborda a recep?ao da literatura brasileira nos Estados Unidos e em outros paises, enfocando, em particular, a obra dos escritores Machado de Assis e Clarice Lispector. Sustento que, nos anos sessenta do seculo XX, a literatura brasileira foi eclipsada pela mais reconhecida literatura hispano-americana, que chegou a dominar o periodo conhecido aqui como o “Boom”, isto e, o momento historico quando a chamada literatura “latino-americana” come?ou a ser aceita na cultura norte-americana. Mas o Brasil nao figurou como jogador importante no “Boom.” A pergunta e: Por que? Como se explica isto? Nao foi questao de qualidade, porque textos do Machado, Clarice, Amado, e outros escritores brasileiros ja existiam em boas tradu?oes em lingua inglesa; foi mais questao da invisibilidade do Brasil na consciencia cultural Americana desta epoca. Se os criticos norte-americanos sabiam um pouco, ao menos, da America Hispânica, nao sabiam nada do Brasil. E fica aqui o problema. Argumento tambem em favor da importância da tradu?ao na recep?ao de Machado e Clarice e do trabalho do ilustre tradutor Gregory Rabassa, que ajudou muito a promover os escritores brasileiros nessa cultura e no mundo das pessoas de lingua inglesa. Comento, finalmente, a presen?a da literatura brasileira globalmente, e como uma for?a vital no fenomeno que, na tradi?ao da Weltliteratur estabelecida pelo Goethe, hoje em dia se chama World Literature.
Iatrogenic closure of coronary sinus: an unforseen complication of surgical atrial septal defect closure.

Cardiac complication following the surgical closure of a secundum atrial septal defect (ASD) is extremely uncommon in the current era. We report a case of 39-year-old male presented with hemoptysis following an ASD closure 21 years prior and diagnosed to have iatrogenic closure of the coronary sinus at the time of surgical ASD closure. To our best knowledge, this is the first case of such complication reported in the literature.
Visual Analysis Plus Hierarchical Linear Model Regressions: Morphosyntax Intervention with Deaf-and-Hard-of-Hearing Students:

We conducted a pilot study using intentional teaching strategies with specially designed materials to improve accuracy and production of targeted English morphosyntax structures with six deaf and h...
The Burn Wound Microenvironment

Significance: While the survival rate of the severely burned patient has improved significantly, relatively little progress has been made in treatment or prevention of burn-induced long-term sequelae, such as contraction and fibrosis. Recent Advances: Our knowledge of the molecular pathways involved in burn wounds has increased dramatically, and technological advances now allow large-scale genomic studies, providing a global view of wound healing processes. Critical Issues: Translating findings from a large number of in vitro and preclinical animal studies into clinical practice represents a gap in our understanding, and the failures of a number of clinical trials suggest that targeting single pathways or cytokines may not be the best approach. Significant opportunities for improvement exist. Future Directions: Study of the underlying molecular influences of burn wound healing progression will undoubtedly continue as an active research focus. Increasing our knowledge of these processes will identify addit...
A Logical Account of NGSCB

As its name indicates, NGSCB aims to be the ”Next-Generation Secure Computing Base”. As envisioned in the context of Trusted Computing initiatives, NGSCB provides protection against software attacks. This paper describes NGSCB using a logic for authentication and access control. Its goal is to document and explain the principals and primary APIs employed in NGSCB.
Adaptive, assessment-based educational games

Assessment-based educational games can produce useful information to guide student instruction This paper describes an approach for integrating components of video games with those of adaptive technologies and assessment into the design of educational games Three examples in the areas of English language learning and mathematics are also presented.
Genetic Information, Ethics, Privacy and Confidentiality: Overview

Introduction Privacy, Confidentiality, and Anonymity Uniqueness of Genetic Information Research Contexts Confidentiality in Clinical Contexts Nonmedical Uses of Genetic Information Keywords: genetics; ethics
Documenting dreams : patient-centered records versus practice-centered records

Thesis (Ph. D.)--Massachusetts Institute of Technology, Sloan School of Management, February 2003.
Music evokes vivid autobiographical memories

Music is strongly intertwined with memories-for example, hearing a song from the past can transport you back in time, triggering the sights, sounds, and feelings of a specific event. This association between music and vivid autobiographical memory is intuitively apparent, but the idea that music is intimately tied with memories, seemingly more so than other potent memory cues (e.g., familiar faces), has not been empirically tested. Here, we compared memories evoked by music to those evoked by famous faces, predicting that music-evoked autobiographical memories (MEAMs) would be more vivid. Participants listened to 30 songs, viewed 30 faces, and reported on memories that were evoked. Memories were transcribed and coded for vividness as in Levine, B., Svoboda, E., Hay, J. F., Winocur, G., & Moscovitch, M. [2002. Aging and autobiographical memory: Dissociating episodic from semantic retrieval. Psychology and Aging, 17, 677-689]. In support of our hypothesis, MEAMs were more vivid than autobiographical memories evoked by faces. MEAMs contained a greater proportion of internal details and a greater number of perceptual details, while face-evoked memories contained a greater number of external details. Additionally, we identified sex differences in memory vividness: for both stimulus categories, women retrieved more vivid memories than men. The results show that music not only effectively evokes autobiographical memories, but that these memories are more vivid than those evoked by famous faces.
Scalp Topography of the P3 Wave in Different Auditory Decision Tasks

Publisher Summary Numerous overlapping psychological constructs have been linked to the P3 wave, including information delivery, uncertainty resolution, salience, orientation and cognitive evaluation, reactive changes of nonspecific state, decision confidence, and response set-selective attention. The validity of such attempts to identify the P3 wave with a particular psychological operation depends upon the un-established proposition that “the P3” is a unitary physiological entity, a rising from a single cerebral generator system, when it occurs in diverse experimental contexts. The chapter describes an experiment in which Ss reclined in an easy chair in a sound-attenuating chamber and fixated a spot on a screen that could be transilluminated with a Grass photo stimulator. Auditory stimuli were delivered binaurally through ear phones. Despite similarities among the P3 topographies, it cannot be concluded that they all arise from a common cerebral generator. In some Ss, the no-go P3 was clearly displaced anteriorly relative to the others. The data were not always extensive enough to certify that particular topographical differences are reliable and valid. There emerged, however, a statistically significant overall trend for the no-go P3 to be situated more anteriorly than the threshold and omitted signal P3S.
Meiosis: Rec8 is the reason for cohesion

During meiosis, sister chromatids produced by chromosome duplication are held together by Rec8, a meiosis-specific cohesion protein. Rec8 joins the whole length of the sister chromatids together, and, as meiosis proceeds, is lost in a stepwise manner that correlates with the loss of sister-chromatid cohesion.
Quasi-optical mode converters for high order mode gyrotrons

A quasi-optical mode converter has been designed to transform the TE/sub 22,6/ cylindrical waveguide mode at 110 GHz to a Gaussian beam in free space. The converter consists of an irregular cylindrical waveguide section followed by a step-cut launching aperture and several focussing reflectors in an open mirror transmission line. The irregular waveguide section, which was designed with coupled mode theory, is used to bunch the radiation into Gaussian bundles prior to the launch. The reflectors that follow were designed with Gaussian optics and diffraction theory. A rigorous diffraction theory has been developed to analyse the converter system. The converter was built and a preliminary test on a MW power level pulsed gyrotron has been completed. A symmetric Gaussian beam output with the predicted beam waist of 0.9 cm was observed. Experimental results are compared to diffraction theory simulations and very good agreement is obtained.
Antibody to the ligand for CD40 (gp39) inhibits murine AIDS-associated splenomegaly, hypergammaglobulinemia, and immunodeficiency in disease-susceptible C57BL/6 mice

Infection of genetically susceptible C57BL/6 mice with the LP-BM5 isolate of murine retroviruses cause profound splenomegaly, hypergammaglobulinemia, lymphadenopathy, and an immunodeficiency syndrome which includes the development of terminal B-cell lymphomas. Because many of these and the other manifestations of LP-BM5 virus-induced disease are similar to those seen in AIDS, this syndrome has been named murine AIDS, or MAIDS. Previous reports have shown that the onset of MAIDS depends on the presence of both CD4+ T cells and B cells and have suggested that CD4+ T-cell-B-cell interactions are important to disease pathogenesis. Here, we assessed the possibility that interactions between CD40 and its ligand on activated CD4+ T cells, CD40 ligand/gp39, are involved in the development of MAIDS. To test this hypothesis, LP-BM5-infected B6 mice were treated in vivo with anti-gp39 monoclonal antibody. As a result, MAIDS-associated splenomegaly, hypergammaglobulinemia, germinal center formation, and the loss of in vitro responsiveness to the T- and B-cell mitogens concanavalin A and lipopolysaccharide were inhibited. Anti-gp39 monoclonal antibody-treated LP-BM5-infected mice were also able to mount essentially normal alloantigen-specific cytolytic T-lymphocyte responses. These results support the possibility that molecular interactions between CD40 and gp39 are critical to the development of MAIDS.
Onset of Schizophrenia at Age 100

Schizophrenia is generally regarded as a disease starting in adolescence and early adulthood. Cases beginning after the age of 60 are rare. The authors present the case of a woman who, at the age of 100, developed an illness marked by delusions and hallucinations and who was diagnosed with schizophrenia, paranoid type. Authors discuss the differential diagnosis of psychotic symptoms presenting late in life.
Flood-Related Work Disruption and Poor Health Outcomes Among University Students

Introduction Globally, floods are the most common and among the most devastating of natural disasters. Natural disasters such as floods impact local businesses, increasing local unemployment by up to 8.2%. Previous research has linked individual losses from disasters with symptoms such as posttraumatic stress disorder. However, little is known about the impact of work disruption and job loss on post-disaster psychological symptoms. University students, who are often living far away from family support structures and have limited resources, may be particularly vulnerable. This study examines student psychological health following a large flood at a university. Hypothesis Students who experienced flood-related job loss or disruption had a higher proportion of psychological symptoms than those who did not experience job loss or disruption, controlling for individual loss such as injury, home loss or evacuation. METHODS: On June 8, 2008, a major flood affected seven US Midwestern states. A total of two dozen people were killed and 148 injured, although no deaths or serious injuries were reported in the population used for this study. At the study university, operations were closed for one week, and 20 buildings were severely damaged. A cross-sectional survey of all students enrolled during the semester of the flood was conducted. Students were sent an online survey six weeks after the flood. In addition to questions about damage to their homes, the survey asked students if their work was disrupted because of the floods. Symptoms of PTSD were measured through the modified Child PTSD Symptom Scale. RESULTS: Of the 1,231 responding students with complete surveys, 667 (54.2%) reported that their work was disrupted due to the floods. Controlling for gender, ethnicity, grade, and damage to the student's home, students reporting work disruption were more than four times more likely to report PTSD symptoms (95% CI, 2.5-8.2). Work disruption was independently associated with decreases in general mental and physical health following the floods, as well as with increases in alcohol use. Conclusion Disaster research has focused on damage to individuals and homes, but there has been little focus on work losses. Individuals who lose their jobs may be a vulnerable population post-disaster. Peek-Asa C , Ramirez M , Young T , Cao Y . Flood-related work disruption and poor health outcomes among university students. Prehosp Disaster Med. 2012;27(6):1-6. Language: en
A quantitative method for the application of compressive forces to bone in tissue culture.

A quantitative method for the application of compressive forces to long bones in culture is described. Using this method it was found that a physiological pressure of 80 g/cm sq. applied to tibiae of 16-day-old chick embryos reduced glucose consumption to 50% of controls. Twenty four hours after the release of pressure glucose utilization again increased, approaching control levels. A pressure of 80 g/cm sq. also stimulated thymidine incorporation into DNA. The same pressure decreased the size of the extracellular fluid pool by 8%, but had no effect on the rate of equilibration of this pool with22Na.
Quantum field-theory models on fractal spacetime. I. Introduction and overview

The present work explores the possibility of giving a non-perturbative definition of the quantum field-theory models in non-integer dimensions, which have been previously studied by Wilson and others using analytic continuation of dimension in perturbation integrals. The method employed here is to base the models on fractal point-sets of non-integer Hausdorff-Besicovitch dimension. Two types of scalar-field models are considered: the one has its propagator (=covariance operator kernel) given by a proper-time or heat-kernel representation and the other has a hierarchical propagator. The fractal lattice version of the proper-time propagator is shown to be reflection-positive. The hierarchical models are introduced and their properties discussed on an informal basis.
The child guidance clinic in a community mental health center: a five-year report.

This report compares the functioning and productivity of a child guidance clinic during 5-year periods before and after the move into a comprehensive community mental health center. The transition was characterized by an accelerating case load, more efficient use of manpower, and diversification of programs despite the loss of organizational autonomy. Children and youth services retained their functional identity in the face of pressures for an undifferentiated intake. Blending of children and adult services, when both are in close proximity, stems from an urgency to serve large numbers of adults but may endanger programs for children.
A dynamic ontology for a dynamic reference work

The successful deployment of digital technologies by humanities scholars presents computer scientists with a number of unique scientific and technological challenges. The task seems particularly daunting because issues in the humanities are presented in abstract language demanding the kind of subtle interpretation often thought to be beyond the scope of artificial intelligence, and humanities scholars themselves often disagree about the structure of their disciplines. The future of humanities computing depends on having tools for automatically discovering complex semantic relationships among different parts of a corpus. Digital library tools for the humanities will need to be capable of dynamically tracking the introduction of new ideas and interpretations and applying them to older texts in ways that support the needs of scholars and students.This paper describes the design of new algorithms and the adjustment of existing algorithms to support the automated and semi-automated management of domain-rich metadata for an established digital humanities project, the Stanford Encyclopedia of Philosophy. Our approach starts with a "hand-built" formal ontology that is modified and extended by a combination of automated and semi-automated methods, thus becoming a "dynamic ontology". We assess the suitability of current information retrieval and information extraction methods for the task of automatically maintaining the ontology. We describe a novel measure of term-relatedness that appears to be particularly helpful for predicting hierarchical relationships in the ontology. We believe that our project makes a further contribution to information science by being the first to harness the collaboration inherent in a expert-maintained dynamic reference work to the task of maintaining and verifying a formal ontology. We place special emphasis on the task of bringing domain expertise to bear on all phases of the development and deployment of the system, from the initial design of the software and ontology to its dynamic use in a fully operational digital reference work.
Evidence for Water at Meridiani

The Mars Exploration Rover Opportunity has examined sedimentary structures in the Burns formation at Meridiani Planum. The materials in this formation reflect, in part, subaqueous deposition of reworked, sulfate-rich, clastic sediments that likely formed in a playa-interdune setting. The chemistry and mineralogy of the sedimentary rocks record an origin by evaporation of sulfate- and chloride-rich brines mixed with a fine, altered, basaltic mud or dust component, prior to reworking. Cementation and postdepositional reactions to form hematite-rich concretions and crystal-mold porosity reflect diagenesis in a groundwater-saturated subsurface. More recent dehydration events are evidenced by polygonal textures in rocks within craters and exposed on the plains. The timing of formation of fracture fillings that cut across bedding is not well constrained and may be early postdiagenetic or later. The fracture fillings may have formed by solutions remobilized along zones of weakness. Alteration rinds may reflect more recent interactions between rock and atmospheric water vapor.
Don't Quit Now!: Crisis, Reflection, Growth, and Renewal for Early Career Teachers

When encountering challenges and obstacles, the reflective practitioner strategically negotiates the issues through a process that leads to professional growth and renewal.