cssi/SciSciGPT-SciSciNet huggingface dataset:
Pyridoxine-Dependent Epilepsy

This chapter focuses on disorders due to mitochondrial respiratory chain (MRC) dysfunction and use the collective term mitochondrial cytopathy. It discusses two mtDNA disorders, myoclonus epilepsy with ragged red fibers (MERRF) and mitochondrial myopathy encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Epilepsy occurs primarily in the group of patients that develop stroke-like lesions (SLL) and seizures are often preceded by or associated with migraine-like headache. Magnetic resonance spectroscopy can demonstrate elevated lactate in regions of the brain, while positron emission tomography (PET) scanning can provide metabolic information suggesting lowered ATP production. Convulsive status epilepticus (CSE) is treated aggressively using traditional protocols. Benzodiazepine infusion is evaluated as a first line together with phosphenytoin and occasionally phenobarbital. The epilepsies in mitochondrial cytopathies often reveal both focal and generalized features. Treatment of mitochondrial cytopathies comprises awareness of the potential complications and early and aggressive control of seizures.
Intracranial Pressure and SvjO2

Intracranial pressure monitoring gives insight into pathophysiological derangement of intracerebral hemodynamics. It may be used to direct and titrate therapy targeted towards optimizing cerebral perfusion and oxygenation, by manipulation of water and blood content of the intracranial cavity. Noninvasive methods are increasingly investigated but suffer challenges in accuracy and pragmatic use. The various invasive approaches include direct monitoring of the ventricular system of the brain, which remains the gold standard. Intraparenchymal methods include a range of fiberoptic and piezoelectric transducers. Combination devices allow brain oxygen tension or brain compliance monitoring. Limitations revolve around the infection risk of the fluid channel in ventricular pressure transduction, as well as accuracy and drift problems in the parenchymal devices. Jugular bulb saturation monitoring (SvjO2) of the cranial venous outflow in combination with the Fick principle provides an estimate of the adequacy of cerebral perfusion to meet cerebral metabolic demand. With intermittent sampling and continuous catheter measurement techniques, it can also provide jugular bulb pressure estimates as well as arteriovenous difference in lactate. Its limitations reside in its averaging of cortical supply versus demand, which limits sensitivity to regional problems.
Quantifying body surface temperature differences in canine coat types using infrared thermography

Abstract Infrared thermography (IRT) has been used to assess the health of canines by measuring surface temperatures. However, little is known about the effect hair coat differences has on expected surface temperature in healthy canines under the influence of hair coat differences. The aim of this study was to identify the influence of coat characteristics in body surface temperature (BST) in canines (Canis lupus familiaris). To determine the changes in BST, an infrared thermal imaging camera (i.e. FLIR B400) was used. Thermal images of the left and right sides of privately-owned dogs (n = 50) were acquired. Each animal acclimated in an indoor environment away from direct sunlight (23 ± 2.0 °C) for 15 min, and images were taken at a distance 0.67 ± 0.24 m. Regions of interest (ROIs) of mean surface temperatures were examined across the lateral surface of each animal. No statistical differences were detected based on laterality (P = 0.08). Mean BSTs were categorized by each dog's hair coat type: short coat (SC), curly coat (CC), long coat (LC), and double coat (DC). These BSTs were then analyzed using two-way analysis of variance, or ANOVA, (Shapiro-Wilk) and pairwise comparison. SC animals had the highest BST (31.77 ± 0.19 °C; P
A Resource Utilization Analytics Platform Using Grafana and Telegraf for the Savio Supercluster

Understanding high performance computing cluster utilization patterns is key for decision making and efficient resource allocation. Cluster utilization statistics are useful for both cluster administrators and users, providing the ability to identify potential issues, plan jobs to minimize time spent in the queue, and identify constrained resources where funds might be focused in the future. Much of the existing data is accessible by the command line, but presenting the statistics visually allows for easier identification of trends and interactive exploration. Programs such as XDMoD exist to perform a similar function, but are not as well-suited towards use-cases of smaller clusters. Instead, we use a stack of open source software, allowing for a high degree of flexibility, including multiple database backends and more user-friendly querying and visualization. Based on open source software, similar software stacks can be deployed at other clusters to fit their existing infrastructure and needs. We present the workflow used by Berkeley Research Computing to consolidate existing data, collect additional utilization information, and display the relevant charts for different use-cases on the Savio supercluster. We have begun collecting, integrating, and displaying job information from Slurm; account association information; and CPU metrics collected with Telegraf. With this data, the Grafana visualization framework is able to present broad summary statistics, such as aggregated usage by campus department, all the way down to the CPU usage on a single node over the course of a job, and all with flexibility for a wide variety of possible needs and use-cases.
Expanding the knowledge on development of CAKUT: molecular genetics and beyond.

We would like to thank Dr. Fernandez-Prado, Dr. Kanbay, Dr. Ortiz, and Dr. Perez-Gomez for their insightful comments on the genetics of CAKUT (congenital abnormalities of the kidney and urinary tract), the zinc finger protein BNC2, and specifically on their commentary on our recent report of BNC2 variants causing lower urinary tract obstruction (LUTO) (1).
Varus-Valgus Constrained Implants With a Mobile-Bearing Articulation: Results of 367 Revision Total Knee Arthroplasties.

Abstract Background Varus-valgus constrained (VVC) implants are used for compromised ligamentous stability in revision total knee arthroplasties (TKAs). Mobile-bearing VVC implants may reduce rotational forces; yet, limited clinical data exist. The purpose of this study is to report mid-term risk of re-revision, complications, and clinical outcomes with a mobile-bearing VVC implant. Methods Three hundred thirty-seven patients (367 TKAs) who underwent revision TKA with a mobile-bearing VVC implant between 1999 and 2013 at a single institution were reviewed. Mean age at revision was 67 years. Mean follow-up was 4 years. The main indications for revision were aseptic loosening in 158 cases (43%), reimplantation after 2-stage exchange arthroplasty in 120 (33%), instability in 61 (17%), and other in 28 (7%). Clinical outcomes were assessed by Knee Society Scores, and survivorship was analyzed with death as the competing risk. Results The 5-year cumulative incidences of any re-revision or re-revision for aseptic loosening were 9% and 3%, respectively. Twenty-six knees (7%) were re-revised: 15 for infection, 6 for aseptic loosening, and 5 for other causes. There were 17 cases of irrigation and debridement, 10 cases of manipulations under anesthesia, and 9 cases of periprosthetic fractures. There were no bearing “spin-outs.” The mean Knee Society Scores improved from 45 preoperatively to 77 at most recent follow-up (P Conclusion The functional improvement and 5-year cumulative incidence of revision of a mobile-bearing VVC implant demonstrated acceptable outcomes with no unique complications related to the mobile-bearing construct. Additional follow-up will be needed to determine long-term implant survivorship.
IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor

Abstract IMAGINE is a high intensity, quasi-Laue neutron crystallography beamline developed at the 85 MW High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory (ORNL). This state-of-the-art facility for neutron-diffraction enables neutron protein structures to be determined at or near atomic resolutions from crystals with volumes of
Great Saphenous Vein Radiofrequency Ablation

This chapter discusses the technique for great saphenous vein radiofrequency ablation, including instrumentation and equipment, patient positioning, and surgical steps. The authors also offer pearls and pitfalls.
Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy.

Autologous gene therapy using lentiviral vectors (LVs) holds promise for treating monogenetic blood diseases. However, clinical applications can be limited by suboptimal hematopoietic stem cell (HSC) transduction and insufficient quantities of available vector. We recently reported gene therapy for X-linked severe combined immunodeficiency using a protocol in which patient CD34+ cells were incubated with two successive transductions. Here we describe an improved protocol for LV delivery to CD34+ cells that simplifies product manipulation, reduces vector consumption, and achieves greater vector copy number (VCN) of repopulating HSCs in mouse xenotransplantation assays. Notable findings include the following: (1) the VCN of CD34+ cells measured shortly after transduction did not always correlate with the VCN of repopulating HSCs after xenotransplantation; (2) single-step transduction at higher CD34+ cell concentrations (2–4 × 106/ml) conserved LV without compromising HSC VCN; (3) poloxamer F108 (LentiBOOST) increased HSC VCN by two- to threefold (average from three donors); (4) although LentiBOOST + prostaglandin E2 combination further increased VCN in vitro, the VCN observed in vivo were similar to LentiBOOST alone; (5) cyclosporine H increased the HSC VCN to a similar or greater extent with LentiBOOST in vivo. Our findings delineate an improved protocol to increase the VCN of HSCs after CD34+ cell transduction with clinically relevant LVs.
Histrionic Personality Disorder

Histrionic personality disorder (HPD) is a personality disorder marked by excessive displays of emotionality and need for attention. HPD owes its historical origins to the early descriptions of ‘hysteria,’ although it gradually evolved into a more circumscribed diagnosis characterized by theatrical displays and interpersonal dysfunction. HPD overlaps markedly with a number of other conditions, including somatization disorder, antisocial personality disorder, and borderline personality disorder, although it is separable from them. A variety of psychotherapeutic approaches have been developed for HPD, although research on the treatment of HPD is still in its infancy.
An empirical analysis of the effect of financial performance on environmental performance of companies in global supply chains

Abstract The relationship between companies’ financial performance (FP) and their environmental performance (EP) has generated a lot of interest among practicing managers and researchers over the years. This is largely because it simultaneously addresses two – economic and environmental – aspects of the three tripods of the triple bottom line phenomenon. In spite of the fact that both directions of the EP-FP link are important, a vast majority of studies have focused on one direction: how EP affects FP. There is a dearth of research on the reverse link and it is thus the focus of our study. Using EP and other archival data for 468 companies representing 10 industry sectors and 32 countries, with hierarchical regression as the main procedure, we examine specifically how FP as measured by return on assets (ROA) and revenue growth (RG) affects EP. We also study how firm size moderates the effect of ROA and RG on EP as well as the effect of industry concentration on EP. We find that RG affects EP, this effect being comparatively stronger for larger firms. Among other things, we also find that industry to which the firms belong by far more explain EP than FP does. Our findings have important implications for practicing managers and also contribute to advancing research on the relationship between FP and EP. Specifically, for example, the results suggest that managers should pay more attention to EP for companies in the industry to which they belong, rather than EP for companies in general.
Supporting the Message, Not the Messenger: The Correlates of Attitudes towards Black Lives Matter

Since the Black Lives Matter movement’s rise to prominence, there has been significant opposition from both media and political figures who believe that the movement is promoting a “war on cops.” Because there is no evidence to support this claim, the current study examines the basis for negative attitudes towards Black Lives Matter using a sample of over 500 undergraduate students from a large Midwestern university. The findings indicate that the strongest predictors of negative attitudes towards Black Lives Matter are being white and holding symbolically racist attitudes. Perceiving the police to be equivalent to soldiers in a war on crime, perceiving police misconduct to be less common, and holding a conservative crime ideology are also significant in the model.
Intersectionality and Identity Configurations: A Qualitative Study Exploring Sexual Identity Development Among Emerging Adults Within the United States:

Although modern comprehensive conceptual models of sexual identity development acknowledge contextual factors, existing models have placed less emphasis on (a) the influence of multiple domains of ...
SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with nonsevere disease.

BACKGROUND: The transfer of passive immunity with convalescent plasma is a promising strategy for treatment and prevention of COVID-19, but donors with a history of nonsevere disease are serologically heterogenous. The relationship between SARS-Cov-2 antigen-binding activity and neutralization activity in this population of donors has not been defined. STUDY DESIGN AND METHODS: Convalescent plasma units from 47 individuals with a history of nonsevere COVID-19 were assessed for antigen-binding activity of using three clinical diagnostic serology assays (Beckman, DiaSorin, and Roche) with different SARS-CoV-2 targets. These results were compared with functional neutralization activity using a fluorescent reporter strain of SARS-CoV-2 in a microwell assay. RESULTS: Positive correlations of varying strength (Spearman r = 0.37-0.52) between antigen binding and viral neutralization were identified. Donors age 48 to 75 years had the highest neutralization activity. Units in the highest tertile of binding activity for each assay were enriched (75%-82%) for those with the highest levels of neutralization. CONCLUSION: The strength of the relationship between antigen-binding activity and neutralization varies depending on the clinical assay used. Units in the highest tertile of binding activity for each assay are predominantly comprised of those with the greatest neutralization activity.
Magnetic Resonance Perfusion Changes of Arteriovenous Malformations Treated with Stereotactic Radiosurgery.

Background The latency period from stereotactic radiosurgery (SRS) to obliteration of arteriovenous malformations (AVM) requires continuous imaging surveillance. Magnetic resonance (MR) perfusion is promising for noninvasive monitoring of AVMs after SRS. We studied longitudinal MR perfusion changes of brain AVMs treated with SRS. Methods Consecutive patients treated for brain AVMs using SRS who had MR perfusion imaging studies performed before and at least once after SRS were studied. We estimated ipsilateral/contralateral brain hemisphere ratios of MR perfusion indexes, including regional cerebral blood flow (rCBF) and relative cerebral blood volume (rCBV), in the AVM nidus, perinidal region, and remote anterior and posterior brain regions. Results Eleven patients (6 women; median age, 21 years) underwent SRS (median prescription dose, 18 Gy; range, 12–20 Gy) for brain AVMs (median Spetzler-Martin grade 2 and median volume 4.6 mL). Before the SRS, rCBV and rCBF ratios were significantly higher in the AVM nidus compared with other investigated brain regions (P Conclusions There is a gradual decrease of rCBV and rCBF in the AVM nidus after SRS. MR perfusion imaging is promising for monitoring of hemodynamic changes of AVMs after SRS. Larger studies investigating clinical value of MR perfusion imaging for AVMs after SRS are warranted.
Modal Network Formulation for the Analysis and Design of Mode-Converting Metasurfaces in Cylindrical Waveguides

Modal network theory has proven to be a useful tool in analyzing waveguide discontinuities. Ports of a modal network correspond to waveguide eigenmodes on either side of the discontinuity. In this work, modal network theory is extended beyond conventional/geometrical waveguide discontinuities. We use the modal network formulation to analyze discontinuities resulting from metasurfaces. Specifically, we analyze azimuthally invariant cascaded sheet metasurfaces placed in a cylindrical waveguide excited by ${\text {TM}}_{0n}$ modes. The metasurface comprises multiple radially varying electric admittance sheets separated by dielectric spacers. We derive the modal representation of a single inhomogeneous, electric sheet admittance using two approaches: a conventional numerical integration approach and a discrete Hankel transform (DHT) approach. We show that the DHT approach is more efficient. Subsequently, the modal matrices of cascaded sheet metasurfaces are derived using the DHT. Finally, we propose an optimization-based procedure to synthesize transparent metasurface-based mode converters. The mode converters transform a set of incident modes on one side to another set of desired modes on the opposite side of the metasurface. Two designs are synthesized at 10 GHz: a single-mode converter, and a mode splitter. The designs are verified using the commercial finite element electromagnetic solvers.
Behavioral Genetics Research and Criminal DNA Databases

INTRODUCTION PART I: THE SCIENCE OF CRIMINAL CONDUCT BEHAVIORAL GENETICS: THE SCIENCE OF ANTISOCIAL BEHAVIOR MISINFORMATION, MISREPRESENTATION, AND MISUSE OF HUMANBEHAVIORAL GENETICS RESEARCH THE DEVELOPMENTAL NEUROSCIENCE OF CRIMINAL BEHAVIOR PART II: CONSIDERING THE BROADER CONTEXT BEHAVIORAL GENETICS AND CRIME, IN CONTEXT CONSIDERING CONVERGENCE: A POLICY DIALOGUE ABOUT BEHAVIORAL GENETICS, NEUROSCIENCE, AND LAW " PART III: REVISITING CRIMINAL RESPONSIBILITY GENETICS, NEUROSCIENCE AND CRIMINAL RESPONSIBILITY ADDICTION, SCIENCE AND CRIMINAL RESPONSIBILITY PART IV: IMPLICATIONS FOR CRIMINAL JUSTICE AND SOCIETY GENOMICS, BEHAVIOR, AND TESTIMONY AT CRIMINAL TRIALS BEHAVIORAL GENETICS EVIDENCE IN CRIMINAL CASES: 1994-2007 BEHAVIORAL GENETICS RESEARCH AND CRIMINAL DNA DATABASES: LAWS AND POLICIES GENETIC PREDICTIONS OF FUTURE DANGEROUSNESS: IS THERE A BLUEPRINT FOR VIOLENCE? THE SCARLET GENE: BEHAVIORAL GENETICS, CRIMINAL LAW, AND RACIAL AND ETHNIC STIGMA APPENDIX APPENDIX TO: BEHAVIORAL GENETICS EVIDENCE IN CRIMINAL CASES: 1994-2007 Index
Examining the racial and ethnic diversity of associate degree in nursing programs by type of institution in the US, 2012-2018.

Abstract Background Increasing nursing workforce diversity is essential to quality health care. Associate Degree in Nursing (ADN) programs are a primary path to becoming a registered nurse and an important source of nursing diversity. Purpose To examine how the number of graduates and racial/ethnic student composition of ADN programs have changed since the Institute of Medicine's recommendation to increase the percentage of bachelor's-prepared nurses to 80%. Methods Using data from the Integrated Postsecondary Education System, we analyzed the number of graduates and racial/ethnic composition of ADN programs across public, private not-for-profit, and private for-profit institutions, and financial aid awarded by type of institution from 2012-2018. Discussion Racial/ethnic diversity among ADN programs grew from 2012-2018. Although private for-profits proportionally demonstrated greater ADN student diversity and provided financial aid institutionally to a higher percentage of students, public schools contributed the most to the number and racial/ethnic diversity of ADN graduates. Conclusion Given concerns regarding private for-profits, promoting public institutions may be the most effective strategy to enhance diversity among ADN nurses.
Global Borderlands: Fantasy, Violence, and Empire in Subic Bay, Philippines: by Victoria Reyes, Stanford, CA, Stanford University Press, 2019, 312 pp., $30.00 (paperback), ISBN 978-1-5036-0941-9

In Global Borderlands: Fantasy, Violence, and Empire in Subic Bay, Philippines, sociologist Victoria Reyes opens up a new direction of inquiry on sovereignty, territoriality, and resistance. In thi...
Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery

Macrophage migration inhibitory factor (MIF) is a multifunctional immunoregulatory protein that is a key player in the innate immune response. Given its overexpression at sites of inflammation in a wide range of diseases marked by increasingly oxidative cellular environment, a comprehensive structural understanding of how cellular redox conditions may impact the structure and function of MIF is necessary. We used solution NMR spectroscopy and mass spectrometry to investigate structural and dynamic signatures of MIF under varied solution redox conditions. Our results indicate that the MIF structure is modified and becomes increasingly dynamic in an oxidative environment, which may be a means to alter the MIF functional response in a redox-dependent manner. We identified latent allosteric sites within MIF that are redox-sensitive and mutational analysis reveals that loss of redox-responsive residues attenuates activation of the coreceptor CD74. Leveraging sites of redox-sensitivity therefore reveals an avenue to modulate MIF function in its disease state via structure-based drug design.
Patterns of Medical Care Cost by Service Type for Patients With Recurrent and De Novo Advanced Cancer

Abstract Objectives There is limited knowledge about the cost patterns of patients who receive a diagnosis of de novo and recurrent advanced cancers in the United States. Methods Data on patients who received a diagnosis of de novo stage IV or recurrent breast, colorectal, or lung cancer between 2000 and 2012 from 3 integrated health systems were used to estimate average annual costs for total, ambulatory, inpatient, medication, and other services during (1) 12 months preceding de novo or recurrent diagnosis (preindex) and (2) diagnosis month through 11 months after (postindex), from the payer perspective. Generalized linear regression models estimated costs adjusting for patient and clinical factors. Results Patients who developed a recurrence Conclusions Our findings reveal distinct cost patterns between patients with de novo stage IV, recurrent
Dementia diagnosis in the hospital and outcomes among patients with advanced dementia documented in the Minimum Data Set.

BACKGROUND Individuals with dementia do not always have a diagnosis of dementia noted on their hospital claims. Whether this lack of documentation is associated with patient outcomes is unknown. We examined the association between a dementia diagnosis listed on a hospital claim and patient outcomes among individuals with a Minimum Data Set (MDS) assessment. METHODS A retrospective cohort study was conducted using administrative claims data and nursing home MDS assessments. Hospitalized patients aged 66 and older with advanced dementia noted on an MDS assessment completed within 120 days prior to their first hospitalization in 2017 were included. Advanced dementia was defined based on an MDS diagnosis of dementia, dependency in four or more activities of daily living, and a Cognitive Function Scale score indicative of moderate to severe impairment. Multilevel regression with a random intercept at the hospital level was used to examine the relationship between documentation of dementia in inpatient hospital Medicare claims and the following patient outcomes after adjusting for patient and hospital characteristics: invasive mechanical ventilation (IMV) use, intensive care unit or coronary care unit (ICU/CCU) use, 30-day mortality, and hospital length of stay (LOS). RESULTS In 2017, among 120,989 patients with advanced dementia and a nursing home stay, 90.57% had a dementia diagnosis on their hospital claims. In adjusted models, documentation of a dementia diagnosis was associated with lower use of the ICU/CCU (adjusted odds ratio [AOR]: 0.78 [95% confidence interval 0.74, 0.81]), use of IMV (AOR: 0.50 [0.47, 0.54]), and 30-day mortality (AOR: 0.81 [0.77, 0.85]). Patients with a dementia diagnosis had a shorter LOS. CONCLUSIONS Among patients with advanced dementia, those whose dementia diagnosis was documented on their inpatient hospital Medicare claim experienced lower use of ICU/CCU, use of IMV, lower 30-day mortality, and shorter LOS than those whose diagnosis was not documented.
7 Ethnic Differences In Risk Factors Associated With Substance Use In Adolescence

Publisher Summary This chapter explores ethnic differences related to family and friend substance use, social supports, and beliefs about the future as predictors of risks and protective factors for substance use among these adolescents. The data for this research study come from the Youth Plus Survey, which is a component of a larger longitudinal study funded by the federal Center for Substance Abuse Prevention. The goal of the Youth Plus Survey is to identify factors related to early adolescent substance use that would assist in the development of substance abuse prevention programs targeting middle school aged children. Data for the Youth Plus Survey are collected from four cohorts. In this study no significant ethnic differences with regard to social support and respondent optimism about the future are found, which are thought to be factors protecting adolescents from risk of substance use. With regard to risk factors, it is found that minority youth reported higher rates of substance use for family members and friends compared to white respondents. Thus, there appear to be no differences in the moderating effects of social networks on the process—that is, the interactions among family/friend use and social supports and future beliefs, or in the protective factors for adolescent substance use among ethnic groups. However, there were ethnic differences in the level of risk for substance use.
An iterative relevance feedback learning algorithm for image retrieval systems

A new feature adaptation mechanism is proposed in this paper that captures the relevance feedback information provided by the expert users. This relevance information is retained for future usage and subsequently made available to other users. The search and retrieval processes are implemented through a two-layer connectionist network structure and the relevance feedback learning is incorporated by appropriately modifying the network structure. The developed algorithm is tested on an electro-optical imagery database collected from different underwater mine-like and non-mine-like objects.
PLACE: a query processor for handling real-time spatio-temporal data streams

The emergence of location-aware services calls for new real-time spatio-temporal query processing algorithms that deal with large numbers of mobile objects and queries. In this demo, we present PLACE (Pervasive Location-Aware Computing Environments); a scalable location-aware database server developed at Purdue University. The PLACE server addresses scalability by adopting an incremental evaluation mechanism for answering concurrently executing continuous spatio-temporal queries. The PLACE server supports a wide variety of stationery and moving continuous spatio-temporal queries through a set of pipelined spatio-temporal operators. The large numbers of moving objects generate real-time spatio-temporal data streams.
Transformational School Principal Leadership Behavior and Its Impact on School Climate

During the last two decades, researchers and theorists have offered a variety of conceptual designs and empirical findings regarding school leadership conduct, as it relates to organizational climate concerns. As a supplement to the literature, this paper will examine the intentions, decisions, behaviors, and school outcomes associated with one senior high school principal who endeavored to recreate his school organization. The purpose of this paper is to further the understanding of how transformational leadership manifests in the school organization, and to determine how it impacts school climate. The study’s findings may be beneficial for school leaders and scholars who wish to better understand the school transformation process. Normal.dotm 0 0 1 106 609 Classrooms for the Future 5 1 747 12.0 0 false 18 pt 18 pt 0 0 false false false /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-ascii-font-family:Cambria; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Cambria; mso-hansi-theme-font:minor-latin;}
Point Sources in the Orion Complex

A 667 sq. deg. region in Orion contains thousands of IRAS sources, including stars, embedded sources, galaxies, as well as clumps in more extended emission (cirrus). Two particular types of sources, visible stars with infrared excesses characteristic of T Tauri stars and invisible, cool, embedded objects (L~25 L-sun) are probably related to the formation of low mass stars in Orion.
Immunological Sequelae of Trichinella spiralis Infection in Mice: Effect on the Antibody Responses to Sheep Erythrocytes and Japanese B Encephalitis Virus

Immunosuppression of the antibody response to Japanese B encephalitis (JBE) virus and sheep erythrocytes (SRBC) was observed in mice infected with Trichinella spiralis. This suppression was paralleled by the presence of fewer antibody-forming cells to SRBC in the spleens of parasitized mice. Both primary and secondary complement-fixing antibody responses to JBE virus were suppressed, but the development of immunological memory was not affected. Parasitized mice demonstrated a normal blastogenic response to phytohemagglutinin and normal serum clearance rate of injected (125)I-labeled immunoglobulin G(2b), although the size of the extravascular fluid compartment was significantly increased. The data presented here and in previous reports suggest that sequential antigenic competition is a possible explanation for the humoral immunosuppression to heterologous antigens caused by T. spiralis infection.
A Continuation of Lewinian Research in the Study of Cooperation and Competition

Lewinian research most relevant to my own sort of investigations into cooperation and competition includes Lewin, Dembo, Festinger & Sears’ (1944) study of level of aspiration, and Morton Deutsch’s (1949 a, b) research on cooperation and competition. In the present paper I will touch on this confluence and how it relates to my work.*
The sun's spottedness as a possible factor in terrestial pressure

The occurrence in the late 1930's of a period of maximum sunspot-activity surpassing greatly in intensity the maxima in the past 60 odd years, coupled with the present availability of a homogeneous series of data from a fairly wide network of stations, stimulates a reexamination of the question of sunspot-pressure relationships and a consideration of the problem on a broader basis.
Mediating terrorism: text and protest in interpretations of The Siege

In this study we focus on the film The Siege (1998), as an illustration of how mediated representations of terrorism serve as a vehicle for Orientalist discourse. This text serves as a specific location of struggle and negotiation over interpretations of media characterizations of Arabs, Arab Americans, Muslims, and Islam. First, we focus on how the film represents these communities and the religion textually. Second, we consider news discourse offering critiques of the film by protesting organizations, and the defenses articulated by some of the film's makers. Third, we explore the interpretations of young U.S. viewers as they resonate with competing facets of the text and with public perspectives. Despite the varied possibilities within the text, these interpretations privileged rather than challenged an underlying Orientalist ideology. Still, news media did acknowledge the contestation of dominant discourse, a potential step toward improved portrayals.
Numerical simulation of 2D buoyant jets in ice-covered and temperature-stratified water

A two-dimensional (2D) unsteady simulation model is applied to the problem of a submerged warm water discharge into a stratified lake or reservoir with an ice cover. Numerical simulations and analyses are conducted to gain insight into large-scale convective recirculation and flow processes in a cold waterbody induced by a buoyant jet. Jet behaviors under various discharge temperatures are captured by directly modeling flow and thermal fields. Flow structures and processes are described by the simulated spatial and temporal distributions of velocity and temperature in various regions: deflection, recirculation, attachment, and impingement. Some peculiar hydrothermal and dynamic features, e.g. reversal of buoyancy due to the dilution of a warm jet by entraining cold ambient water, are identified and examined. Simulation results show that buoyancy is the most important factor controlling jet behavior and mixing processes. The inflow boundary is treated as a liquid wall from which the jet is offset. Similarity and difference in effects of boundaries perpendicular and parallel to flow, and of buoyancy on jet attachment and impingement, are discussed. Symmetric flow configuration is used to de-emphasize the Coanda effect caused by offset.
Convergence to constant equilibrium for a density-dependent selection model with diffusion

We consider the classical single locus two alleles selection model with diffusion where the fitnesses of the genotypes are density dependent. Using a theorem of Peter Brown, we show that in a bounded domain with homogeneous Neumann boundary conditions, the allele frequency and population density converge to a constant equilibrium lying on the zero population mean fitness curve. The results agree with the case without diffusion obtained by Selgrade and Namkoong. Frequency and density dependent selection is also considered.
Strengthening by high densities of nanometer-size precipitates: Oxides in Ni

We have measured the yield strengths of Ni samples having high densities of nanometer-size precipitates. Surface layers containing NiO or γ-Al2O3 precipitates were formed in Ni specimens by ion implanting O alone or O and Al, with subsequent annealing. The yield strengths of the layers were obtained through nanoindentation in conjunction with finite-element simulations. The yield strengths of the Ni alloys were combined with earlier data for O-implanted Al and compared to predictions of a recent treatment of the Orowan mechanism, in which dislocations loop around precipitates and by-pass them. The strengths vary with changes in precipitate microstructure, as predicted, and conform to the theory in absolute magnitude to within a factor of 1.5. This agreement extends over broad microstructural ranges: precipitate sizes from ∼1 to 20 nm, volume fractions from 0.05 to 0.30, densities from 4×1016/cm3 to as high as ∼1020/cm3, edge-to-edge spacings as small as 1.4 nm, two precipitated phases, and two metal matrices with shear moduli differing by a factor of 3. Ion implantation increases near-surface yield strengths to as high as 5 GPa, suggesting that this treatment may be useful for hardening the surfaces of Ni components in micro-electromechanical systems.
Group Approaches for Improving Strategic Decision Making: A Comparative Analysis of Dialectical Inquiry, Devil's Advocacy, and Consensus

This laboratory study compared the effectiveness of the dialectical inquiry, devil's advocacy, and consensus approaches to strategic decision making by groups. Results showed that both dialectical ...
Culture confronts Marx

Focuses on the thought of representative social scientists who rejected the Marxian class/exploitation thesis and opted for a cultural interpretation of development. Explores the contributions of Max Weber, Horace Plunkett, Edward Banfield and George Foster. Each stressed popular commitment to some rendition of the work ethic as the key to economic “take‐off”. Collectively, the writings of these “cultural” social scientists represent an alternative to the Marxian class/ exploitation thesis.
In vivo measurements of the contributions of protein synthesis and protein degradation in regulating cardiac pressure overload hypertrophy in the mouse

Cardiac hypertrophy is generated in response to hemodynamic overload by altering steady-state protein metabolism such that the rate of protein synthesis exceeds the rate of protein degradation. To determine the relative contributions of protein synthesis and degradation in regulating cardiac hypertrophy in mice, a continuous infusion strategy was developed to measure myocardial protein synthesis rates in vivo. Osmotic mini-pumps were implanted in the abdominal cavity to infuse radiolabeled leucine in mice that are conscious and ambulatory. Protein synthesis rates were calculated by measuring incorporation of leucine into myocardial protein over 24 h prior to each time point and dividing by the specific radioactivity of plasma leucine. Compared to sham-operated controls, fractional rates of protein synthesis (Ks) increased significantly at days 1 and 3 of TAC, but was lower on day 7 and returned to control values by day 14. These changes coincided with the curvilinear increase in LV mass that characterizes the hypertrophic response. Fractional rates of protein degradation (Kd) were calculated by subtracting the rate of myocardial growth from the corresponding Ks value. Kd fell at days 1 and 3 of TAC, increased at day 7 and returned to control on day 14. Thus, the increase in LV mass generated in response to pressure overload is caused by acceleration of Ks and suppression of Kd. As the growth rate slows, a new steady-state is achieved once the hypertrophic response is completed.
Stimulation of prostaglandin biosynthesis by adenine nucleotides. Profile of prostaglandin release by perfused organs.

Prostaglandin release from various isolated perfused organs is characteristically dependent on the stimulus; thus, certain stimuli caused prostaglandin release in some organs and not in others. Adenosine triphosphate and adenosine diphosphate were potent stimulators of prostaglandin biosynthesis in the kidney, spleen, spleen fat pad, heart, liver and lung; adenosine monophosphate and adenosine were inactive. Epinephrine caused prostaglandin release from the kidney, spleen, and liver, whereas, angiotensin was agonistic in the kidney, spleen, spleen fat pad, and liver. Indomethacin abolished the release (biosynthesis) of prostaglandins from all organs by each agonist.
Intensified-CCD focal plane detector for space applications: a second generation.

An intensified-CCD detector system developed for space applications from commercially available components is described. This detector uses components which are readily available and are mechanically, thermally, and optically coupled to produce the final compact system. The CCD is cooled using a Peltier-effect thermoelectric cooler to reduce thermal noise. The image is formed on the photocathode of a proximity-focused image intensifier and is transferred fiber-optically from the intensifier to the CDD. Various photocathode and window materials are used to optimize the system for use within the wavelength range extending from the far UV to the near IR. The basic design, including the image intensifier, intensifier-CCD interface, CCD array, cooling, electronics, and mounting, and the detector performance are described in detail.
Long-term clinical and radiographic stability after clip reconstruction of a midbasilar dissecting mycotic aneurysm.

Objective Mycotic aneurysm rupture has been described as a rare, universally fatal complication of central nervous system Coccidioides immitis meningitis. Recently, however, we reported the successful surgical management of a midbasilar dissecting mycotic aneurysm related to C. immitis meningitis in a 24-year-old pregnant woman with acquired immune deficiency syndrome. Methods A 24-year-old pregnant woman with known acquired immune deficiency syndrome and a history of C. immitis meningitis presented to our institution with subarachnoid and intraventricular hemorrhage. Diagnostic cerebral angiography revealed a dissecting, midbasilar aneurysm involving the right anterior inferior cerebellar artery and causing stenosis of the proximal basilar artery. Through a retrosigmoid craniotomy, clip reconstruction of the basilar artery under hypothermic circulatory arrest was performed. The patient was neurologically intact at discharge (postoperative day 19) with the exception of mild disconjugate gaze and headache. Results At her 53-month follow-up, the patient was neurologically intact with only mild disconjugate gaze on upgaze. There was no evidence of local aneurysm recurrence or regional aneurysm formation, and the basilar artery was patent. Her C. immitis meningitis was well controlled. The patient is maintained on oral highly active antiretroviral therapy and an antifungal regimen. Conclusions Our patient represents the only survivor of a C. immitis mycotic aneurysm rupture. In her case, long-term clinical and radiographic stability were achieved through a vigilant multidisciplinary approach.
Linking global market segmentation decisions with strategic positioning options

Purpose – The purpose of this paper is to examine empirically the relationship between positioning strategies and bases of segmentation in international markets.Design/methodology/approach – A principal component analysis was conducted to determine the major macro‐ as well as micro‐bases of segmentation that are linked with strategic positioning decision options. Further, a regression analysis was used to examine the effect of each of the segmentation bases on the different strategic positioning options used by segmentation managers.Findings – This study suggests the combined use of both macro‐ and micro‐bases of segmentation in order to leverage similar strategic positioning across global markets. However, micro‐bases of segmentation are suggested for firms seeking differential positioning strategies.Research limitations/implications – The conceptual and empirical findings of this study pave the way for embarking on promising and relevant future research that is needed to substantiate and enrich the acad...
L∞-compensation with mixed sensitivity as a broadband matching problem

A simplified approach to the design of a mixed-sensitivity, L∞-optimal compensator is developed. Mixed-sensitivity L∞-compensation is reduced, in a rather straightforward way, to Melton's broadband matching problem, which has itself received an elegant operator-theoretic solution. The simplicity of the approach developed herein allows a clarification of some issues which have emerged in less transparent mathematical settings.
A study of the Ag(s)/Ag2SO4(l) high temperature reference electrode

Ag(s)/Ag2SO4(l) reference electrodes for use in hot corrosion research were fabricated and their properties were studied at 927°C (1200°K). The McDanelTM MV 30 mullite tube was used as sheath of the reference electrode and concentrations of the tested electrolytes were varied from 0.1 to 10 m/o Ag2SO4 (l) + Na2SO4 (l). 10 m/o Ag2SO4 was always used as electrolyte in the reference electrode. The working electrodes with less than 2 m/o Ag2SO4 showed marked potential drift as the Ag2SO4 concentration was lowered, showing poor potential stability. However, the initial values of cell voltages obeyed Nernstian behavior for all range of Ag2SO4 concentrations in the working electrodes, which showed that Ag(s)/Ag2SO4(l) electrodes behaved reversibly. Galvanostatic polarization was performed on a pair of 10 m/o Ag2SO4 reference electrodes to test the reversibility. The polarizability was 3.5 mV/10 μA with no hysteresis loop on the polarization curve, showing that the reversibility was satisfactory. The potential of gold electrode in molten Na2SO4 was measured under pure oxygen atmosphere with 10 m/o Ag2SO4 electrode as a reference potential. The results showed that the potential of gold electrode could be explained by the 2 Na + SO3 + 1/2 O2 Na2SO4 cell reaction. Untersuchung einer Ag(s)/Ag2SO4(l)–Hochtemperaturbezugselektrode Es wurden Ag(s)/Ag2SO4(l)-Bezugselektroden fur den Einsatz in der Hochtemperaturkorrosionsforschung hergestellt und ihre Eigenschaften bei 927°C untersucht. Als Mantel der Bezugselektroden kam ein McDanelTM MV 30 Mullitrohr zum Einsatz. Die Konzentrationen der untersuchten Elektrolyten variierten zwischen 0,1 und 10 m/o Ag2SO4(l) + Na2SO4 (l). Der Elektrolyt in der Bezugselektrode bestand immer aus 10 m/o Ag2SO4. Die Arbeitselektroden mit weniger als 2 m/o Ag2SO4 zeigten eine deutliche Potentialverschiebung, wenn die Ag2SO4-Konzentration verringert wurde, und damit eine schwache Potentialstabilitat. Die Anfangswerte der Zellenspannungen wiesen jedoch fur alle Bereiche der Ag2SO4-Konzentrationen in der Arbeitselektrode Nernstsches Verhalten auf. Dies zeigte, das sich die Ag(s)/Ag2SO4 (I)-Elektroden reversibel verhielten. Galvanostatische Polarisation wurde an einem Paar von 10 m/o Ag2SO4-Bezugselektroden durchgefuhrt, um die Reversibilitat zu testen. Die Polarisierbarkeit betrug 3,5 mV/ 10 μA ohne Hysterese-Schleife in der Polarisationskurve und deutete somit an, das die Reversibilitat zufriedenstellend war. Das Potential der Goldelektrode in geschmolzenem Na2SO4 wurde unter reiner Sauerstoffatmosphare mit einer 10 m/o Ag2SO4-Elektrode als Bezugspotential gemessen. Die Ergebnisse ergaben, das das Potential der Goldelektrode durch die 2 Na + SO 3 + 1/2 O2 Na2SO4-Zellenreaktion erklart werden kann.
Electron energy levels in superconducting and magnetic nanoparticles

Abstract We describe electron-tunneling measurements of the spectrum of discrete energy levels for electrons in metal nanoparticles, for metals with sufficiently strong electron interactions to form superconducting or magnetic states. For aluminum nanoparticles, superconducting pairing interactions produce an energy gap for tunneling, which affects even- and odd-electron spectra differently. As a function of an applied magnetic field, we observe that the correlated electron ground state is disrupted by breaking one Cooper pair at a time. Energy levels in ferromagnetic cobalt particles exhibit effects of strong exchange and magnetic anisotropy forces, with a non-linear, hysteretic dependence on an applied magnetic field.
On the border of extreme and mild spiked models in the HDLSS framework

In the spiked covariance model for High Dimension Low Sample Size (HDLSS) asymptotics where the dimension tends to infinity while the sample size is fixed, a few largest eigenvalues are assumed to grow as the dimension increases. The rate of growth is crucial as the asymptotic behavior of the sample Principal Component (PC) directions changes dramatically, from consistency to strong inconsistency at the boundary of the extreme and mild spiked covariance models. Yet, the behavior at the boundary spiked model is unexplored. We study the HDLSS asymptotic behavior of the eigenvalues and the eigenvectors of the sample covariance matrix at the boundary spiked model and observe that they show intermediate behavior between the extreme and mild spiked models.