cssi/SciSciGPT-SciSciNet huggingface dataset:
Cultural Factors, Economic Affiliations And The Adoption Of International Financial Reporting Standards

We examine cultural characteristics in the context of economic affiliation and the timing of IFRS adoption. Prior work identifies cultural characteristics as key factors in the development of accounting systems world-wide. Our analysis extends this literature by showing that these same factors lead to economic clusters and to the propensity for adopting a universally accepted set of accounting rules. We contribute to the literature by demonstrating that, at least in one case, cultural factors are able to predict economic affiliations. Second, we provide evidence that certain cultural characteristic are affiliated with the delay in adoption of IFRS. Our results are valuable to local as well as international accounting standard setters as they look to negotiate common ground for convergence. Our examination of the cultural aspects distinctive in adoption patterns may provide insight into what specific aspects of the IFRS must be modified to expand and accelerate convergence.
Intracellular distribution of heat‐induced stress glycoproteins

Cellular heat stress results in elevated heat-shock protein (HSP) synthesis and in thermotolerance development. Recently, we demonstrated that protein glycosylation is also an integral part of the stress response with the identification of two major stress glycoproteins, GP50, associated with thermotolerance, and P-SG67, the "prompt" stress glycoprotein induced immediately during acute heat stress. In the present study, we characterized the subcellular location and redistribution of these proteins during the cellular injury and recovery phase. In unheated and heated CHO cells, both stress glycoproteins were present in each subcellular fraction isolated by differential centrifugation. However, the subcellular redistribution in the course of cellular recovery after heat stress was specific for each stress glycoprotein. GP50 was present in all subcellular fractions before heat stress, but showed relatively little redistribution after heat stress. By 24 h of recovery following stress, GP50 showed partial depletion from lysosomes and microsomes, and was mainly present in the mitochondria. Glycosylated P-SG67 was redistributed in a more complex fashion. It was seen predominantly in the lysosomes and microsomes immediately following heat-stress, but after 6 h of recovery following heat stress, it largely disappeared from the microsomes and was present mainly in the cytosol. By 24 h of recovery following heat stress, it was found predominantly in the nucleus-rich fraction and mitochondria. The localization of GP50 and P-SG67 by subcellular fractionation is consistent with immunolocalization studies and contrasts with the translocation of HSP70 after heat stress from cytosol to nuclei and nucleoli. These results reflect a characteristic distribution for each stress glycoprotein; their presence in virtually all subcellular fractions suggests multifunctional roles for the various stress glycoproteins in the cellular heat stress response.
Understanding the Relationship Between Civic Skills and Civic Participation: Educating Future Public Managers

This paper suggests that fundamental elements of civic and political participation are skill-based and therefore must be practiced in order to be learned. Scholars have long included a notion of civic skills as central to theoretical constructs of both political participation and civic education, but exactly what is meant by civic skills is often vaguely defined. This paper defines civic skills, briefly summarizing the links between civic skills and civic and political participation and discusses the implications for what students should be learning and how programs should be teaching.
Greening Economy as a Key Solution to the Economic Crisis

Although the UN called for a “Global Green New Deal” as a response to the current financial and economic crisis and the “American Recovery and Reinvestment Act of 2009” (ARRA) includes “green” stimulus incentives, there is unfortunately far from a consensus on whether such green incentives will serve as a solution to the current financial and economic crisis. To answer this fundamental question, we will analyze and identify one of the more deeply rooted structural problems of the U.S. economy, the wasteful depletion of finite fossil fuels, and its relationship with three of the major problems facing the U.S. economy – global financial crisis, skyrocketing energy prices, and climate change. We argue that the triple predicament of the existing carbon-based U.S. economy can be ultimately cured by the development and implementation of a comprehensive visionary “green” economic strategy to accelerate the transition to a greener economy.
A grammar-based approach to model the patient's clinical trajectory after a mild traumatic brain injury

Despite the significant amount of longitudinal information that Electronic Health Records (EHRs) include, modeling the progression of a particular disease is still a challenging task. Generally, when the trajectory of a cohort of patients is analyzed some patients take similar paths from/to a certain clinical disease while others take vastly different paths. Most existing approaches to analyze trajectories of a patient have focused on a specific disease with the intention of being able to predict whether a new patient will develop a similar diagnosis or not. This paper presents a novel approach to identifying the trajectory of patients by modeling the clinical path as an automata and using grammar induction to reduce the graph. The resulting reduced model represents the common trajectory for the patients without incorporating events that are specific to a particular patient. The proposed model has been tested with 5,000 patients that have sustained a mild traumatic brain injury (mTBI) and have developed post-traumatic stress disorder (PTSD). The model has produced a trajectory indicating the common clinical path that those patients take from their first mTBI to their first diagnosis of PTSD.
A Comparison on Metric Dimension of Graphs, Line Graphs, and Line Graphs of the Subdivision Graphs

The \emph{line graph} $L(G)$ of a simple graph $G$ is the graph whose vertices are in one-to-one correspondence with the edges of $G$; two vertices of $L(G)$ are adjacent if and only if the corresponding edges of $G$ are adjacent. If $S(G)$ is the \emph{subdivision graph} of a graph $G$, then the \emph{para-line graph} $G^*$ of $G$ is $L(S(G))$. The \emph{metric dimension} $\dim(G)$ of a graph $G$ is the minimum number of vertices such that all vertices are uniquely determined by their distances to the chosen vertices. In this paper, we study metric dimension of para-line graphs; we also compare metric dimension of graphs, line graphs, and para-line graphs. First, we show that $\lceil \log_2 \Delta(G) \rceil \le \dim(G^{\star}) \le n-1$, for a simple and connected graph $G$ of order $n \ge 2$ with the maximum degree $\Delta(G)$, where both bounds are sharp. Second, we determine the metric dimension of para-line graphs for some classes of graphs; further, we give an example of a graph $G$ such that $\max\{\dim(G), \dim(L(G)), \dim(G^{\star})\}$ equals $\dim(G)$, $\dim(L(G))$, and $\dim(G^{\star})$, respectively. We conclude this paper with some open problems.
Accessibility of Internet websites through time

Using Internet Archive's Wayback Machine, a random sample of websites from 1997-2002 were retrospectively analyzed for effects that technology has on accessibility for persons with disabilities and compared to government websites. Analysis of Variance (ANOVA) and Tukey's HSD were used to determine differences among years. Random websites become progressively inaccessible through the years (p
Congressional Internships & Experiential Learning: The Odyssey of Political Science Students on Capitol Hill

This panel of Political Science undergraduate students is intended to provide an opportunity for UDC students who are currently participating in Congressional internships to discuss and assess how these experiential learning experiences have contributed to their intellectual and professional growth. Utilizing local resources available to our land grant institution tasked with serving the residents of the District of Columbia, the UDC Political Science Program is in the process of expanding our students’ opportunities to learn about governmental institutions, political power and policymaking in a hands-on program whereby students are equipped, through our curriculum and faculty mentoring, with the skills needed to succeed in the workplace environment of a Congressional office by connecting traditional classroom undergraduate education with community based high-impact experiential opportunities. Students will discuss 1) their experience in the preparatory stages of program curriculum and mentoring, 2) their process of introduction and initiation into the “culture” of Capitol Hill, 3) how these experiences have allowed them to better understand both the personal and institutional production and exercise of power, 4) their first-hand experience of immersion into the world of the legislative process 5) their experience as policy researchers and analysts where applicable, and 6) what they have learned about the relations between governmental institutions, partisan politics, legislative outcomes and, ultimately, how this effects themselves and their communities. Gaining these perspectives and experiences through “community based” learning experiences, and drawing insights from staff research assignments, journal entries, position papers, reflection essays, and policy position papers, these students will detail how their experiences on the Hill, related to their academic mentorship, have prepared them for a life of active citizenship and social agency. Student Participants are: Reginald Davis, University of the District of Columbia Monica Sarmiento, University of the District of Columbia Naji Mujahid, University of the District of Columbia Amoy Reid, University of the District of Columbia Ben Marcus, University of the District of Columbia Ciara Robinson, University of the District of Columbia Cheick O. Diakite, University of the District of Columbia
Pituitary response to TRH and LHRH in spontaneously hypertensive rats.

SummaryThe LH response to LHRH and the TSH and PRL response to TRH were examined in spontaneously hypertensive rats and normotensive control Wistar rats to determine if the pituitary response to these releasing hormones is altered in the hypertensive rats. Although basal levels of LH were similar in the two groups of rats, the LH response to LHRH was significantly less in the hypertensive rats than in the normotensive controls. The spontaneously hypertensive rats had higher basal levels of TSH and PRL and significantly greater TSH and PRL responses to TRH. The results of this study suggest that the hypothalamo-pituitary axis is altered in the spontaneously hypertensive rat.
The Law of Sines and Law of Cosines for Polygons

(1971). The Law of Sines and Law of Cosines for Polygons. Mathematics Magazine: Vol. 44, No. 3, pp. 150-153.
Impact of Subspecialization on the Intraoperative Diagnosis of Ovarian Lesions: A Review of 831 Cases

Subspecialization in surgical pathology is an ongoing discussion in many institutions. Complete subspecialization is only feasible in large centers. However, partial subspecialization is more common and is implemented for areas recognized by the American Board of Pathology (eg, neuropathology, dermatopathology). Our study compares accuracy of intraoperative frozen section evaluations (FS) of ovarian lesions by gynecologic pathologists (GYN Path) vs …
On the importance of event detection for ASR

The performance of modern large vocabulary continuous speech recognition (LVCSR) systems is heavily affected by segment boundaries, proper speaker identification of the segments, as well as removal of spurious data. We propose to use Long Short Term Memory (LSTM) recurrent neural networks to partition audio into speech segments as well as track speaker turns. Additionally, we train an LSTM to also identify music segments. We show that the accurate detection of events, along with removal of silence and music, using our LSTM yields a 9–10% relative improvement in ASR performance. Secondary processing by speaker clustering provides an additional boost in accuracy. Event detection accuracy of the LSTM approach is also described.
Capable Cross-links: Polymersomes Reinforced with Catalytically Active Metal–Ligand Bonds

Polymersomes, hollow spherical nano-to-microscale polymer assemblies, have increasingly become important constructs in the development of biomimetic materials that expand the library of functional and robust analogs to lipid-based vesicles. As compared to liposomes, polymersomes possess superior physical properties and the nearly unlimited potential for synthetic fine-tuning. Herein we improve on the physical properties of these polymer vesicles by introducing platinum-based metal–ligand cross-links into the hydrophobic core, which gave the vesicles demonstrated resistance to destabilization by surfactants over un-cross-linked polymersomes. The formation of cross-links was capable of being selectively reversed by the addition of phosphines. In addition, the Pt(0) cross-links retained their catalytic activity for the hydrosilylation of alkenes.
Central Leptin and Tumor Necrosis Factor-α (TNFα) in Diurnal Control of Blood Pressure and Hypertension

Leptin and TNFα can individually work in the brain to affect blood pressure; however, it remains unknown whether these two cytokines might have an interactive role in this process and, if so, how. In this work, we found that leptin stimulation led to TNFα production under both in vitro and in vivo conditions, and diurnal fluctuation of leptin concentrations in the cerebrospinal fluid predicted the circadian changes of TNFα gene expression in the hypothalamus. Signaling analysis showed that leptin stimulation led to a rapid and strong STAT3 activation followed by a second-phase moderate STAT3 activation, which was selectively abolished by anti-inflammatory chemical PS1145 or TNFα antagonist WP9QY. Physiological study in normal mice revealed that diurnal rise of blood pressure was abrogated following central administration of PS1145 or a leptin receptor antagonist. Central TNFα pretreatment was found to potentiate the effect of leptin in elevating blood pressure in normal mice. In pathophysiology, dietary obesity mimicked TNFα pretreatment in promoting leptin-induced blood pressure rise, and this effect was blocked by central treatment with either PS1145 or WP9QY. Hence, central leptin employs TNFα to mediate the diurnal blood pressure elevation in physiology while enhancement of this mechanism can contribute to hypertension development.
The Death of Public Transportation

When [Indonesia] commemorating the National Transportation Day on 17 September, 2011, the conditions of land, sea and air transport infrastructures have been dying, crying for the participation of all components of the nation; the streets are crowded, not full of public transport vehicles, but dominated by private vehicles and motorcycles instead. The high density of motor vehicles is causing tremendous congestion, poor air quality, wasteful spending on components because the vehicle parts wear out fast, wasteful fuel consumption and, ultimately, the people’s vulnerability to illness.
Differential effects of IκB molecules on tat-mediated transactivation of HIV-1 LTR

Abstract The tat gene product of the human immunodeficiency virus type 1 (HIV-1) strongly induces the transcription directed by the viral long terminal repeat (LTR). Tat acts by interacting with a target RNA element located immediately downstream of the initiation site. In addition, the action of Tat appears to be assisted by the upstream DNA enhancer elements, including the binding sites for the NF-κB/Rel family of host transcription factors. In the present study, we demonstrate that Tat transactivation of the HIV-1 LTR is markedly inhibited by several cytoplasmic inhibitors of NF-κB/Rel, suggesting the critical involvement of these host transcription factors in the function of the viral Tat protein. Furthermore, the various NF-κB inhibitors appear to have differential effects on Tat. While IκBα, IκBβ, and p100 potently inhibit Tat-mediated transactivation, p105 fails to inhibit, but even moderately synergizes, the action of Tat. We further demonstrate that the action of these NF-κB/Rel inhibitors on Tat correlates with their inhibitory activities on the RelA subunit of NF-κB. Finally, we show that a degradation-resistant IκBα mutant is able to potently inhibit Tat-mediated activation of the HIV-1 LTR in both untreated and tumor necrosis factor α-stimulated T cells, thus suggesting that such an IκBα mutant may serve as a constitutive repressor of HIV-1 LTR.
Frequency-dependent hoarding by Sciurus carolinensis occurs with seeds of similar perceived value

Seed predation and rodent foraging behaviors depend on frequency of available seeds and seed traits. However, the interaction of frequency of seed availability and seed traits adds a new level of complexity to granivore–seed dynamics. We conducted experiments with eastern gray squirrels ( Sciurus carolinensis ) designed to elucidate the frequency × trait interaction. We hypothesized that frequency-dependent caching should occur only among pairs of seeds that are relatively similar in attributes that affect their perceived value as a storable food item. We also tested whether caching decisions were dependent on seeds already cached, a variable rarely considered in seed dispersal studies. Frequency-dependent seed caching occurred when seeds of relatively similar value ( Juglans regia and Castanea mollissima ) were paired. For this seed pair, caching decisions by S. carolinensis were dependent on seeds already cached such that squirrels tended to cache seeds that were either rare in the environment or in the cache. When seeds of very different caching values were paired ( Juglans nigra and Corylus americana ), a strong preference for the high-value seed was observed, but no frequency-dependent selection. We conclude that in pairings of seeds of differential caching value, the highly preferred seed is cached regardless of frequency of availability. In contrast, when seeds of similar value are paired, rarer (more common) seeds are cached at a higher (lower) rate than expected, and this behavior potentially stabilizes seed survival across available seed types leading to increased tree diversity. Our results indicate that caching of seeds by squirrels, and by implication recruitment of seedlings into plant populations, is likely driven by complex interactions between the relative frequency of seeds and their traits. We expect similar patterns to occur in any system in which foragers select among resource types that vary in perceived value.
Intelligent On-Line Decision Support Tools For Market Operators

The deregulation of the electric power industry has evolved rapidly and market operators are facing new challenges to resolve issues with system operations and market operations. This paper intends to demonstrate the potential of using intelligent decision support tools to assist market operations. Business rule approach has been selected for system design and development. Domain knowledge of market operations are captured in a common knowledgebase. Several application areas are identified and prototypes have been developed to validate the applicability and feasibility of rule-based technology in market operation environment.
Gut microbiota composition associated with alterations in cardiorespiratory fitness and psychosocial outcomes among breast cancer survivors.

In this proof-of-concept pilot study, our purpose was to determine correlations between gut microbiota composition and alterations in cardiorespiratory fitness and psychosocial outcomes among post-primary treatment breast cancer survivors (BCS). Composition of the gut microbiota in BCS (n = 12) was assessed at baseline (M0) and at the end of 3 months (M3) using Illumina MiSeq DNA Sequencing of the 16S rRNA gene. Gut microbiota composition was analyzed using the QIIME bioinformatics software and represented through diversity metrics and taxa analyses. Cardiorespiratory fitness, fatigue, anxiety, depression, and sleep dysfunction were assessed at M0 and M3 via the submaximal treadmill test, Fatigue Symptom Inventory, Hospital Anxiety and Depression Scale, and Pittsburgh Sleep Quality Index, respectively. Increased fatigue interference in BCS was associated with increased mean within-sample Shannon diversity (organism richness and evenness) (p = 0.009). Weighted UniFrac analysis (shifts in taxa relative abundance) revealed significant differences in between-sample (beta) diversity for changes in fatigue interference (p = 0.01) and anxiety (p = 0.022), with a trend observed for fatigue intensity and sleep dysfunction (p < 0.1). Unweighted UniFrac analysis (shifts in taxa types) found significant beta diversity differences for cardiorespiratory fitness (p = 0.026). Prior to false discovery correction (FDR), changes in fitness, fatigue, anxiety, and sleep dysfunction were associated with the frequency of certain gut bacteria genera (e.g., Faecalibacterium, Prevotella, Bacteroides) (p < 0.05). Correlations may exist between alterations in gut microbiota composition and longitudinal changes in cardiorespiratory fitness, fatigue, and anxiety in BCS. Further research examining the role of the microbiota-gut-brain axis in exercise-induced effects on psychosocial outcomes in BCS is warranted.
Isotope Effects in Low Energy Ion-Atom Collisions

Isotope effects for charge transfer processes have recently received increased attention. The ion-atom merged-beams apparatus at Oak Ridge National Laboratory is used to measure charge transfer for low energy collisions of multi-charged ions with H and D and is therefore well suited to investigate isotope effects. The apparatus has been relocated and upgraded to accept high velocity beams from the 250 kV High Voltage Platform at the Multi-Charged Ion Research Facility. The intense higher velocity multi-charged ion beams allow, for the first time, measurements with both H and D from keV/u down to meV/u collision energies in the center-of-mass frame. When charge transfer occurs at relatively large inter-nuclear distances (via radial couplings) the ion-induced dipole attraction can lead to trajectory effects, causing differences in the charge transfer cross sections for H and D. A strong isotope effect (nearly a factor of two) has been observed in the cross section for Si4+ + H(D) below 0.1 eV/u. However, little or no difference is observed for N2+ + H(D). Recently, strong effects have been predicted for the fundamental system He2+ + H(D,T) at collision energies below 200 eV/u where charge transfer occurs primarily through united-atom rotational coupling. We are currently exploring systemsmore » where rotational coupling is important and isotopic differences in the cross section can be observed.« less
The Single-Cell Yin and Yang of Live Imaging and Transcriptomics

A new approach to monitoring both signaling over time and a global gene expression profile from the same cell establishes a functional role for NF-κB dynamics in transcription.
Augmenting Interpersonal Communication through Connected Lighting

This paper describes a system, WeLight, that we developed to facilitate communication. It allows individuals to configure the lights in one another's homes as well as their own. We describe this system and its motivation from exploratory interviews with households using existing connected lighting products. To ease inter-household communication, we integrated connected lights, specifically Phillips Hue and LIFX, with widely adopted messaging services, such as SMS. To support spontaneous communication within and across households, we developed scene creation capabilities involving natural language processing and image search. We also describe features intended to enhance spoken conversation, specifically light adjustment according to speech content and sentiment.
Hybrid silicon / lithium niobate waveguide micro-chips stable to 300°

Bonded silicon-on-insulator and lithium niobate-on-insulator dies are shown to be thermally stable up to 300° over a 67.2 mm2 bonded area. Optical propagation through a waveguide on this bonded hybrid silicon-lithium niobate platform is performed.
The Efficiency of Stock-Based Incentives: Experimental Evidence

ABSTRACTThe authors report the results of laboratory experiments in which subjects are offered contracts structured similar to equity compensation packages and result in subjects receiving cash payments that are a function of their effort and random factors. The authors compare the outcomes from alternative contractual forms to theoretical benchmarks and report the efficiency of the contracts to provide evidence on whether options or stocks that have same economic cost to the employer yield the same or different effort levels from the managers. Both contracts elicit lower levels of effort than would be chosen by an expected-payoff-maximizing decision maker. Effort choices under the option contract did not differ significantly from effort choices under the stock contract except for male subjects. The option contract elicits a higher effort level for these subjects and condition than the stock contract. Effort choices reflect loss aversion and regret based on past stock price realizations.
Why is cognitive change more negative with increased age

Objective The primary goal of the current study was to investigate factors contributing to more negative cognitive change at older ages. Method Longitudinal data on 12 cognitive tests were examined in 2,637 adults ranging from 18 to 85 years of age. Because both the intervals between measurement occasions and the number of occasions varied across participants, it was possible to investigate effects of interval and number of measurement occasions on cognitive change in adults of different ages. In addition, about 1/2 of the participants performed alternate versions of the tests on a second and third session on the first occasion, which allowed change to be monitored over intervals of less than 1 week. Results Regression analyses revealed that cognitive change was more negative with increases in the interval between occasions but was more positive with additional measurement occasions. Both the effects of interval and of number of measurement occasions were similar across adulthood. Increased age was associated with more positive gains over a period of a few days but was associated with more negative declines when the intervals between occasions averaged about 3 years. Conclusions This combination of results suggests that longitudinal change in cognitive functioning is more negative at older ages not because of greater declines with increases in the interval between measurement occasions, or because of smaller gains with additional measurements. Instead most of the age differences in change may be due to greater losses of benefits associated with the initial assessment over intervals of months or more from the initial assessment. (PsycINFO Database Record
Race, Criminalization, and Historical Trauma in the United States: Making the Case for a New Justice Framework

The punitive policies and practices of the United States criminal punishment system have exacerbated social ills ranging from trauma, mental illness, homelessness, unemployment, family dissolution, and substance abuse. It is increasingly viewed as a dehumanizing system that reproduces social exclusi
Ring/Shell Ion Distributions at Geosynchronous Orbit

One year's worth of plasma observations from geosynchronous orbit is examined for ion distributions that may simultaneously be subject to the ion Bernstein (IB) instability (generating fast magnetosonic waves) and the Alfven cyclotron (AC) instability (generating electromagnetic ion cyclotron waves). Confirming past analyses, distributions with robust ∂fp(v⊥)/∂v⊥>0 near v||=0, which we denote as “ring/shell” distributions, are commonly found primarily on the dayside of the magnetosphere. A new approach to high-fidelity representation of the observed ring/shell distribution functions in a form readily suited to both analytical moments calculation and linear dispersion analysis is presented, which allows statistical analysis of the ring/shell properties. The ring/shell temperature anisotropy is found to have a clear upper limit that depends on the parallel beta of the ring/shell (®||r) in a manner that is diagnostic of the operation of the AC instability. This upper limit is only reached in the post-noon events, which are primarily produced by the energy- and pitch-angle dependent magnetic drifts of substorm-injected ions. Further, it is primarily the leading edge of such injections, where the distribution is strongly ring-like, that the AC instability appears to be operating. By contrast, the ratio of the ring energy to the Alfven energy remains well within the range 0.25-4.0 suitable for IB instability throughout essentially all of the events, except those that occur in denser cold plasma of the outer plasmasphere.
A Retrospective Analysis of Incident Cardiac and Neurological Co-Morbidity Following Treatment of Acute Promyelocytic Leukemia

Abstract Background Depending on the risk of disease, the use of all-trans retinoic acid (ATRA) combined with arsenic trioxide (ATO) and/or anthracyclines is the current standard for therapy of acute promyelocytic leukemia (APL). Despite the high rates of remission and overall survival (OS) that approach 100%, the extent and characterization of long-term morbidity following treatment in these patients is unknown. We performed a retrospective study to investigate the long-term clinical course of these patients. Methods We performed a retrospective analysis of adult patients with newly diagnosed APL from 2004 through 2014. Therapeutic regimens were ATRA+ATO-based (LoCoco et al. NEJM 2013;369:2), ATRA+anthracycline+ATO-based per CALBG 9710 (Powell et al. Blood 2010;116:19), ATRA+anthracycline+mitoxantrone-based per PATHEMA (Sanz et al. Blood 2004;103), and ATO+ATRA+gemtuzumab per SWOG S0535 (ASCO 2015). Co-morbidities were documented at diagnosis and extracted from the medical record, including the date of incident event. Long-term comorbidities were defined as those occurring mostly > 6 months after complete remission (CR). Patients were followed from the time of presentation to death or censored at last known follow-up. The cumulative incidence of co-morbid conditions after diagnosis was calculated by the Fine and Gray method, with relapse and death as competing risks. OS and progression-free survival (PFS) were calculated by the Kaplan and Meier method. Results We identified 116 patients with a new diagnosis of APL. Of the 116 patients, 102 (88%) achieved CR. 54 patients were treated per CALBG 9710, 17 were treated per LoCoco et al., 24 were treated per PATHEMA, and 6 were treated per SWOG S0535. 5 patients relapsed during follow up, and underwent hematopoietic stem cell transplantation. OS for all groups was 91.3%, 89.5%, 88.5% at 1, 12, and 24 months, respectively. PFS was 91.3%, 88.6%, 85.6% at 1, 12, and 24 months, respectively. Each of the 102 patients achieving CR had an echocardiogram after completion of chemotherapy; of these, 13 (12.7%) had newly depressed ejection fraction Conclusions APL is a highly curable form of leukemia but patients undergoing treatment may face significant long-term cardiac and neurologic co-morbidities regardless of the treatment regimens. It is critical that future care strategies incorporate treatments to improve and prevent comorbid effects of anti-leukemic treatment, potentially incorporating cardiac and neurological care into survivorship guidelines. Download : Download high-res image (89KB) Download : Download full-size image Disclosures Fathi: Bexalata: Other: Advisory Board participation; Merck: Other: Advisory Board participation; Seattle Genetics: Consultancy, Other: Advisory Board participation, Research Funding; Celgene: Consultancy, Research Funding; Agios Pharmaceuticals: Other: Advisory Board participation.
Statistical Factor Analysis and Related Methods

(1996). Statistical Factor Analysis and Related Methods. Journal of Quality Technology: Vol. 28, No. 1, pp. 132-132.
Fermi arcs connect topological degeneracies

In condensed matter and photonics, topology is defined with respect to the energy bands in momentum space ( 1 ). The boundary between two topologically different phases (for example, supporting right- versus left-handed particles) appears as degeneracies where two linear dispersion bands intersect. Fundamental point degeneracies in two-dimensional (2D) and 3D Hermitian systems—known as Dirac and Weyl points, respectively—have been observed in photonic structures ( 2 – 6 ) but not the ideal Weyl points and the helicoidal dispersion, which leads to the open Fermi arcs connecting points of opposite chirality. On page 1013 of this issue, Yang et al. ( 7 ) demonstrate an ideal Weyl system with four Weyl points ( 8 , 9 ) and helicoidal surface Fermi arcs interconnecting them in a 3D photonic crystal composed of metallic inclusions. On page 1009 of this issue, Zhou et al. ( 10 ) explore non-Hermitian topological photonics in which radiative losses come into play, and demonstrate the emergence of bulk Fermi arc and half topological charges in a 2D-periodic photonic crystal.
The Next-Generation Goddard Convective–Stratiform Heating Algorithm: New Tropical and Warm-Season Retrievals for GPM

AbstractThe Goddard convective–stratiform heating (CSH) algorithm, used to estimate cloud heating in support of the Tropical Rainfall Measuring Mission (TRMM), is upgraded in support of the Global Precipitation Measurement (GPM) mission. The algorithm’s lookup tables (LUTs) are revised using new and additional cloud-resolving model (CRM) simulations from the Goddard Cumulus Ensemble (GCE) model, producing smoother heating patterns that span a wider range of intensities because of the increased sampling and finer GPM product grid. Low-level stratiform cooling rates are reduced in the land LUTs for a given rain intensity because of the rain evaporation correction in the new four-class ice (4ICE) scheme. Additional criteria, namely, echo-top heights and low-level reflectivity gradients, are tested for the selection of heating profiles. Those resulting LUTs show greater and more precise variation in their depth of heating as well as a tendency for stronger cooling and heating rates when low-level dBZ values d...
Matching Statistics to Graphs

Sometimes it is reported that the average lawyer earns a lot of money; at the same time, the median income of lawyers is reported to be more modest. One year the average team in the National Football League made a sizable profit while the median team barely broke even. People often confuse the mean and the median of a distribution. How are these statistics related to the shape of the distribution?
Efficacy and Risks of Chiropractic Manipulation

Abstract Chiropractors account for around 90% of the manipulation in the United States, and more than 94% of chiropractic patients receive some form of manipulation. This article reports on two studies of the appropriateness of manipulation conducted at RAND using systematic literature reviews and expert panels. Two areas were focused on: manipulation for low-back pain and manipulation and mobilization of the cervical spine. The systematic review of the literature (including a meta-analysis) for the evidence for manipulation for low-back pain indicated that spinal manipulation was more efficacious than the comparison treatments for patients with acute or sub-acute low-back pain uncomplicated by sciatica. For cervical manipulation, the systematic literature review indicated efficacy for neck pain and for patients with muscle-tension-type headache. For both cervical manipulation and manipulation for low-back pain, the literature reports low levels of complications. For cervical manipulation, the estimated risk for serious complications is 6.39 per 10 million manipulations. For lumbar manipulation the estimate is 1 serious complication per 100 million manipulations. Although the evidence of the efficacy for manipulation is not overwhelming, there is sufficient evidence to establish efficacy for acute conditions and sufficient evidence to warrant serious investigation of its efficacy in other areas. The risk from manipulation is low and compares favorably to other forms of therapy for the same conditions (e.g., 15.6 complications per 1000 cervical spine surgeries, 3.2 per 1000 subjects for nonsteroidal anti-inflammatory drugs).
Environmental Perchlorate and the Thyroid

Perchlorate is a competitive inhibitor of the sodium–iodide symporter (NIS) and has been used in pharmacological doses to treat hyperthyroidism, especially iodine-induced hyperthyroidism. Perchlorate appears to be ubiquitous in the environment, and has been detected in trace amounts in the urine in almost all subjects evaluated both in the United States and Europe. In large doses, it has been used as an antithyroid agent by decreasing the entrance of iodide into the thyroid. NIS is also present in the lactating breast. In many clinical and environmental studies of subjects exposed to perchlorate, there is no convincing evidence that the low quantities found in the environment adversely affect thyroid function. Perchlorate salts are potent oxidizers and are used in solid propellants for rockets and missiles, fireworks, road flares, matches, and auto air bag inflation systems. Several clinical studies have not reported any adverse effects of perchlorate on thyroid function in newborns, pregnant women, and nonpregnant adults. Since it has been suggested that the fetus and infant might be more susceptible to the adverse effects of perchlorate on neonatal thyroid function, the perchlorate content of breast milk and infant formulae was assessed. Perchlorate was detected in all breast milk samples (median, 9.1 μg/l) and in 17 infant formulae (median, 1.5 μg/l). There was no correlation between breast milk perchlorate and breast milk iodine content, even in those 27 samples with perchlorate concentrations greater than 10 μg/l.
Multitemporal LiDAR improves estimates of fire severity in forested landscapes

Landsat-based fire severity maps have limited ecological resolution, which can hinder assessments of change to specific resources. Therefore, we evaluated the use of pre- and post-fire LiDAR, and combined LiDAR with Landsat-based relative differenced Normalized Burn Ratio (RdNBR) estimates, to increase the accuracy and resolution of basal area mortality estimation. We vertically segmented point clouds and performed model selection on spectral and spatial pre- and post-fire LiDAR metrics and their absolute differences. Our best multitemporal LiDAR model included change in mean intensity values 2–10 m above ground, the sum of proportion of canopy reflection above 10 m, and differences in maximum height. This model significantly reduced root-mean-squared error (RMSE), root-mean-squared prediction error (RMSPE), and bias when compared with models using only RdNBR. Our top combined model integrated RdNBR with LiDAR return proportions <2 m above ground, pre-fire 95% heights and pre-fire return proportions <2 m above ground. This model also significantly reduced RMSE, RMSPE, and bias relative to RdNBR. Our results confirm that three-dimensional spectral and spatial information from multitemporal LiDAR can isolate disturbance effects on specific ecological resources with higher accuracy and ecological resolution than Landsat-based estimates, offering a new frontier in landscape-scale estimates of fire effects.
Advanced cancer patients' self-reported perception of timeliness of their referral to outpatient supportive/palliative care and their survival data.

10121Background: Palliative Care referral is often thought to be delayed as judged by health professionals and caregivers. However, no studies have ever examined patients’ perception of timeliness ...
Cyber-Physical Transactions: A Method for Securing VANETs with Blockchains

Blockchains are used to perform state agreement in a distributed system. However, there is no way to validate off-chain actions, such as physical actions, in the current architecture. This paper proposes a new blockchain architecture which features locally physically-verified transactions. From this new architecture, this paper presents a protocol for securing vehicular ad-hoc networks (VANETs) without the need to constantly communicate with roadside units (RSUs) or other infrastructure components. However, issues such as privacy in VANETs and Blockchains are left to future work. This paper shows the results from simulations of the current system in order to note its weaknesses. In particular, this paper can be used as a benchmark to show that ideas such as Proof-of-Work and full blockchain validation cannot work in a purely peer-to-peer VANET.
A CLOT TO REMEMBER: INTRAOPERATIVE WATCHMAN THROMBUS FORMATION

Cerebral vascular events (CVA) are amongst the most devastating complications of atrial fibrillation (AF). Anticoagulation (AC) is the mainstay of treatment in preventing CVA, but carries the risk of bleeding. An alternative to AC is left atrial appendage occluder device (LAAO). Complications
Development of Leadership Self-Efficacy: Comparing Engineers, Other STEM, and Non-STEM Majors

The purpose of this work in progress research paper is to examine the differences in leadership self-efficacy among engineering undergraduates and their peers in other fields, and understand how leadership self-concept changes from the first through the fourth year of college. This study conceptualizes engineering formation as a professional identity development process, cultivated through participation in engineering communities of practice. The guiding hypothesis is that experiences that contribute to engineering identity, which focus on the development of technical mastery, conflict with the development of leadership self-concept. This work presents preliminary analysis of the differences between engineering undergraduates and their peers with regard to their leadership experiences during college. Preliminary results reveal a complex picture of the differences between engineering students and their peers in other STEM and non-STEM fields. Engineering students have the highest leadership self-efficacy of all three groups by the end of the fourth year of college, which mirrors differences in self-rated leadership skills at college entry. However, differences in leadership experiences during college vary among these three groups, and not consistently with their leadership self-efficacy. Engineers are least likely to participate in a leadership training during college and to value becoming a leader after college. Among engineering students, students who participate in internships, undergraduate research, and collaborate with peers report higher leadership. Leadership is unrelated to plans to enter engineering as a career.
Modeling-Based Assessment of 3D Printing-Enabled Meniscus Transplantation

3D printing technology is able to produce personalized artificial substitutes for patients with damaged menisci. However, there is a lack of thorough understanding of 3D printing-enabled (3DP-enabled) meniscus transplantation and its long-term advantages over traditional transplantation. To help health care stakeholders and patients assess the value of 3DP-enabled meniscus transplantation, this study compares the long-term cost and risk of this new paradigm with traditional transplantation by simulation. Pathway models are developed to simulate patients’ treatment process during a 20-year period, and a Markov process is used to model the state transitions of patients after transplantation. A sensitivity analysis is also conducted to show the effect of quality of 3D-printed meniscus on model outputs. The simulation results suggest that the performance of 3DP-enabled meniscus transplantation depends on quality of 3D-printed meniscus. The conclusion of this study is that 3DP-enabled meniscus transplantation has many advantages over traditional meniscus transplantation, including a minimal waiting time, perfect size and shape match, and potentially lower cost and risk in the long term.
“Seeing the Life”: Redefining Self-Worth and Family Roles Among Iraqi Refugee Families Resettled in the United States

Social and geographic displacement is a global phenomenon that precipitates novel stressors and disruptions that intersect with long-standing familial and social roles. Among the displaced are war-torn Iraqi refugee families, who must address these new obstacles in unconventional ways. This study explores how such disruptions have influenced associations between gender and apparent self-worth experienced by Iraqi refugee families upon relocation to the USA. Further, the psychosocial mechanisms requisite of any novel approach to a new social construct are explored and reveal that production in the family is at the core of instability and shifting power dynamics during resettlement, preventing family members from “seeing the life” in the USA that they had envisioned prior to immigration. Over 200 semi-structured qualitative interviews with Iraqi participants and mental health providers were conducted over the course of the study, which demonstrate a plasticity among social roles in the family and community that transcends the notion of a simple role reversal, and illustrate the complex positionalities that families under stress must approximate during such physical and social displacement.
1, 2, 3, 4. I declare…empowerment? A material-discursive analysis of the marketisation, measurement and marketing of women’s economic empowerment

Adopting Karen Barad’s material-discursive feminism, this paper investigates how human/non-human elements intra-act and blur together across time and space to produce the phenomena and paradoxes of...
Bismuth for Controlled Assembly/Disassembly of Transition-Metal Oxo Clusters, Defining Reaction Pathways in Inorganic Synthesis and Nature.

Trivalent bismuth is a unique heavy p-block ion. It is highly insoluble in water, due to strong hydrolysis tendencies, and known for low toxicity. Its lone pair is structure-directing, providing fr...
Intra-Subject Variability and Diurnal Cycle of Ocular Perfusion Pressure as Characterized by Continuous Telemetry in Nonhuman Primates.

Purpose To characterize ocular perfusion pressure (OPP) fluctuations with continuous telemetry over 24-hour periods across multiple days in nonhuman primates (NHPs) to test the hypotheses that OPP differs among NHPs and that the diurnal cycle of OPP is characterized by low OPP during sleep. Methods We have developed and validated two implantable radiotelemetry systems that allow continuous measurement of intraocular pressure (IOP), arterial blood pressure (BP), and OPP up to 500 Hz. OPP was measured unilaterally in 12 male NHPs for periods of 38 to 412 days. IOP transducers were calibrated directly via anterior chamber manometry, and OPP was calculated continuously as central retinal artery BP minus IOP. OPP data were corrected for signal drift between calibrations and averaged hourly. Results OPP varied widely among animals, with daily averages ranging from ∼47 to 65 mm Hg. In eight of 12 NHPs, OPP was significantly lower during sleep compared to waking hours. In three animals, the diurnal cycle was reversed and OPP was significantly higher during sleep (P < 0.05), and one NHP showed no diurnal cycle. Day-to-day OPP variability within NHPs was the largest source of overall OPP variability, even larger than the differences between NHPs. Average daily OPP showed an unexplained ∼32-day cyclic pattern in most NHPs. Conclusions Average OPP varied widely and exhibited differing diurnal cycles in NHPs, a finding that matches those of prior patient studies and indicates that OPP studies in the NHP model are appropriate. Infrequent snapshot measurements of either IOP or BP are insufficient to capture true IOP, BP, and OPP and their fluctuations.