cssi/SciSciGPT-SciSciNet huggingface dataset:
Non-pulmonary complications after lung transplantation: part II

Lung transplantation (LT) is a viable therapeutic option in the treatment of advanced lung disease. With improvements in post-transplant survival, complications involving different organ systems after LT are increasingly seen. While non-infectious, extrapulmonary complications after LT are not frequently responsible for early post-transplant mortality, they significantly impact the quality of life and long-term survival. These complications are, therefore, becoming increasingly relevant as patients with LT are living longer. These complications encompass almost all organ systems and are driven by a combination of the pre-existing comorbidities, events, and complications around the operative procedure and recovery, and perhaps most importantly, medication side effects of the post-LT regimen. In the first of the two-part review, we covered the general approach to management of extrapulmonary complications and covered specific complications pertaining to cardiovascular, renal, neuropsychiatric, and ophthalmologic organ systems. In the current article, we discuss most relevant complications pertaining to the hematologic, endocrine, and gastrointestinal organ systems. In addition, we discuss two of the most common and consequential complications under the miscellaneous category, namely malignancy and venous thrombo-embolism after LT. These two complications have gained increasing significance in the lung allocation score era where progressively sicker and older patients are being transplanted.
Human Factors and the Future of Work

In future systems, human factors will be held at least partly accountable for job design, human performance, and the quality of work life. Inevitably, the specific future of technology, systems, and work is uncertain, but expectations of both maximum worker productivity and job satisfaction are societal requirements that surely will be demanded. It is doubtful that these goals will ever be fully met, but the degree to which they are achieved will be directly dependent upon the contributions of human factors.
New functions from old scaffolds: how nature reengineers enzymes for new functions

Publisher Summary This chapter describes how nature has reengineered some protein scaffolds for a range of functions by examining a small number of example superfamilies. The goal is to illustrate on how organizing very distantly related proteins into superfamilies provides a useful context for understanding evolutionary protein engineering, that cannot be achieved by even the most elegant analysis of single proteins, one at a time. The chapter discusses the three enzyme superfamilies, the enolase, vicinal oxygen chelate fold (VOC), and haloacid dehalogenase (HAD) superfamilies, that effectively exemplify some of the different types of structural engineering that nature has employed over the course of evolution. The enolase superfamily scaffold is an α/β barrel, one of the most common and best characterized fold types in all of biology. Analysis of protein superfamilies through explicit mapping of common functional characteristics to conserved structural elements among very distantly related homologs provides a valuable conceptual approach to connecting sequence, structure, and function in ways that are important for understanding both natural and laboratory-based protein engineering.
Sensory neurons are PARtial to pain.

Recent insights into the receptors expressed by sensory neurons are providing the beginnings of a biological basis for designing therapies to block nociceptive information before it reaches the spinal cord. This approach could potentially avoid some of the side effects in the central nervous system caused by currently available analgesics. (pages 821–826 )
Scheduling file transfers for data-intensive jobs on heterogeneous clusters

This paper addresses the problem of efficient collective scheduling of file transfers requested by a batch of tasks. Our work targets a heterogeneous collection of storage and compute clusters. The goal is to minimize the overall time to transfer files to their respective destination nodes. Two scheduling schemes are proposed and experimentally evaluated against an existing approach, the Insertion Scheduling. The first is a 0-1 Integer Programming based approach which is based on the idea of time-expanded networks. This scheme achieves the minimum total file transfer time, but has significant scheduling overhead. To address this issue, we propose a maximum weight graph matching based heuristic approach. This scheme is able to perform as well as insertion scheduling and has much lower scheduling overhead. We conclude that the heuristic scheme is a better fit for larger workloads and systems.
Narratives of Dispossession: The Persistence of Famine in Postcolonial Irish Fiction

This essay demonstrates the ways in which two thematically and structurally similar novels, Nuala O’Faolain’s My Dream of You (2001) and Joseph O’Connor’s Star of the Sea (2002), complicate popular uses of the Famine narrative in arguments on both sides of the debate over Irish independence. By calling forth ghosts from the 19th century to expose both intentional and unintentional misrepresentations of the Famine (imagery, ideological meaning, and political mandate), O’Faolain and O’Connor redefine modern Ireland in terms of hunger and dispossession, revealing a more complex national narrative and a more cosmopolitan national identity.
Observations on the Role of TcdE Isoforms in Clostridium difficile Toxin Secretion.

Clostridium difficile is a major nosocomial pathogen and the principal causative agent of antibiotic-associated diarrhea. The toxigenic C. difficile strains that cause disease secrete virulence factors, toxin A and toxin B, that cause colonic injury and inflammation. C. difficile toxins have no export signature and are secreted by an unusual mechanism that involves TcdE, a holin-like protein. We isolated a TcdE mutant of the epidemic {"type":"entrez-nucleotide","attrs":{"text":"R20291","term_id":"774925","term_text":"R20291"}}R20291 strain with impaired toxin secretion, which was restored by complementation with functional TcdE. In the TcdE open reading frame (ORF), we identified three possible translation start sites; each translated isoform may play a specific role in TcdE-controlled toxin release. We created plasmid constructs that express only one of the three TcdE isoforms and complemented the TcdE mutant with these isoforms. Western blot analysis of the complemented strains demonstrated that TcdE is translated efficiently from the start codon at the 25th and 27th positions in the predicted ORF, producing proteins with 142 amino acids (TcdE142) and 140 amino acids (TcdE140), respectively. TcdE166 was not detected when expressed from its own ribosomal binding site (RBS). The effects of all three TcdE isoforms on C. difficile cell viability and toxin release were determined. Among the three isoforms, overexpression of TcdE166 and TcdE142 had a profound effect on cell viability compared to the TcdE140 isoform. Similarly, TcdE166 and TcdE142 facilitated toxin release more efficiently than did TcdE140. The importance of these variations among TcdE isoforms and their role in toxin release are discussed. IMPORTANCE C. difficile is a nosocomial pathogen that has become the most prevalent cause of antibiotic-associated diarrhea in North America and in several countries in Europe. Most strains of C. difficile produce two high-molecular-weight toxins that are regarded as the primary virulence factors. The mechanism by which these large toxins are secreted from bacterial cells is not yet clear but involves TcdE, a holin-like protein. In this work, we show that TcdE could be translated from three different start codons, resulting in the production of three TcdE isoforms. Furthermore, we investigated the role of these isoforms in toxin release and cell lysis in C. difficile. An understanding of TcdE-dependent toxin secretion may be helpful for the development of strategies for preventing and treating C. difficile infections.
Bone Formation and Resorption in Bone Disorders

The recognition of the majority of disorders of skeletal bone depends largely upon their radiological appearance. The various pathological processes may then be further differentiated by alteration in such biochemical parameters as the plasma calcium and phosphorus levels.
Radio emission from the close binary b Persei

WE report the detection of faint intermittent radio emission from the close binary star b Persei. Concurrent observations at 2,695 and 8,085 MHz were made with the NRAO interferometer on spacings of 900, 1,800 and 2,700 m. The total observing time was 14.4 h, mostly in short periods between February 7 and February 15, 1972. Further brief observations were obtained on April 28 and June 21, 1972.
Why computational thinking should be integrated into the curriculum

Computational Thinking (CT) is an approach to problem solving that consolidates logic skills with core computer science concepts. This survey paper reviews recent efforts to integrate CT into primary, secondary and post-secondary curricula. The paper should prove beneficial to instructors interested in investigating this important topic.
Water Transport Properties of the Grape Pedicel during Fruit Development: Insights into Xylem Anatomy and Function Using Microtomography

Xylem flow of water into fruits declines during fruit development, and the literature indicates a corresponding increase in hydraulic resistance in the pedicel. However, it is unknown how pedicel hydraulics change developmentally in relation to xylem anatomy and function. In this study on grape (Vitis vinifera), we determined pedicel hydraulic conductivity (kh) from pressure-flow relationships using hydrostatic and osmotic forces and investigated xylem anatomy and function using fluorescent light microscopy and x-ray computed microtomography. Hydrostatic kh (xylem pathway) was consistently 4 orders of magnitude greater than osmotic kh (intracellular pathway), but both declined before veraison by approximately 40% and substantially over fruit development. Hydrostatic kh declined most gradually for low (less than 0.08 MPa) pressures and for water inflow and outflow conditions. Specific kh (per xylem area) decreased in a similar fashion to kh despite substantial increases in xylem area. X-ray computed microtomography images provided direct evidence that losses in pedicel kh were associated with blockages in vessel elements, whereas air embolisms were negligible. However, vessel elements were interconnected and some remained continuous postveraison, suggesting that across the grape pedicel, a xylem pathway of reduced kh remains functional late into berry ripening.
Food quality and foraging response by the subterranean termite Coptotermes formosanus shiraki (isoptera: rhinotermitidae)

In previous laboratory studies, it was demonstrated that baldcypress ( Taxodium distichum ) diets eliminated a critical gut protozoan, Pseudotrichonympha grassii , from Coptotermes formosanus Shiraki. The present authors surveyed field colonies of C. formosanus confined within baldcypress trees growing in a river in Louisiana and found P. grassii was present. Termites inhabiting baldcypress trees preferred pine ( Pinus ) and rejected baldcypress in choice tests in the field. Significantly more termites were recruited to baits when twice as much pine was offered, indicating that C. formosanus adjusted its foraging response to resource amount. In laboratory tests, sound baldcypress sapwood and heartwood depressed survival and gut protozoan counts in C. formosanus , but baldcypress infected with the basidiomycete fungus Rigidoporus sp. and an unidentified imperfect species was favourable for the termites and their symbionts. These results suggest an important role for microbial modification in termite host selection.
Lunar paleointensity from three Apollo 15 crystalline rocks using an A.R.M. method

An anhysteretic remanent magnetization method described by Banerjee and Mellema (1974) is used in the lunar paleointensity studies reported. The range of the difference in the paleointensity values obtained by the new method is not quite as great as the range of differences ordinarily found in values determined with the conventional method reported by Thellier and Thellier (1959). The results of the investigation show that the three Apollo 15 rocks studied acquired their natural remanent magnetization in a finite-sized magnetic field which was two or three orders of magnitude greater than the present ambient interplanetary field at the moon.
An eigenfunction solution of entry flow in a semi-infinite pipe at low Reynolds numbers

The developing flow in a semi-infinite pipe is solved for by an eigenfunction method. The results are applicable to zero and low Reynolds number flows. The eigenfunction method yields a solution which accurately predicts overshoots in the axial velocity for small axial positions. Results are presented for both uniform and non-uniform inlet conditions. The latter condition has important implications for numerical simulations of the developing flow problem.
Gendering Work: Deconstructing the Narrative of the Japanese Economic Miracle

The story of the Japanese system, held up as a model for economic prosperity and growth, underplays the role of non-standard labour in the narrative of `success'. Our analysis deconstructs the narr...
A Menu-Driven Block Oriented Programming Language for Digital Fuel Controls

Digital gas turbine fuel controls are not easily programmed in either assembly or high level languages. The interface between the controls engineer and the programming methodology is strained at best. This paper presents a language that is menu-driven and block oriented to allow the control designer to generate a user programmable control design.Copyright © 1985 by ASME
Upregulation of Inflammatory Mediators in a Model of Chronic Pain after Spinal Cord Injury

Chronic neuropathic pain is a disabling condition observed in large number of individuals following spinal cord injury (SCI). Recent progress points to an important role of neuroinflammation in the pathogenesis of central neuropathic pain. The focus of the present study is to investigate the role of proinflammatory molecules IL-1β, TNF-α, MCP-1, MMP-9 and TIMP-1 in chronic neuropathic pain in a rodent model of SCI. Rats were subjected to spinal cord contusion using a controlled linear motor device with an injury epicenter at T10. The SCI rats had severe impairment in locomotor function at 7 days post-injury as assessed by the BBB score. The locomotor scores showed significant improvement starting at day 14 and thereafter showed no further improvement. The Hargreaves’ test was used to assess thermal hyperalgesia for hindpaw, forepaw and tail. A significant reduction in withdrawal latency was observed for forepaw and tail of SCI rats at days 21 and 28, indicating the appearance of thermal hyperalgesia. Changes in expression of mRNAs for IL-1β, TNF-α, MCP-1, MMP-9 and TIMP-1 were assessed using real-time polymerase chain reaction in spinal cord including the injury epicenter along with regions above and below the level of lesion at day 28 post-injury. A significant increase was observed in the expression of MCP-1, TNF-α, TIMP-1 and IL-1β in the injury epicenter, whereas only TIMP-1 was upregulated in the area below the injury epicenter. The results of the study suggest that prolonged upregulation of inflammatory mediators might be involved in chronic neuropathic pain in SCI, and that TIMP-1 may play a role in maintenance of chronic below level pain.
Percutaneous laryngeal collagen augmentation for treatment of parkinsonian hypophonia.

Abstract Objective: Our goal was to determine whether percutaneous laryngeal collagen augmentation improves hypophonia in parkinsonian patients. Study Design and Setting: A retrospective review of 18 patients was performed. Patients and/or caretakers were called on the telephone and asked about their response to the procedure, if any. Videostroboscopic examinations for all patients were reviewed. Results: Of 18 patients, 11 (61%) reported improvement in their hypophonia for a period of at least 2 months. Five of 7 patients without improvement were relatively aphonic both before and after the procedure. Five of 7 patients without improvement had severe dysphagia, which in 3 necessitated gastrostomy tube placement. Four of 7 patients without improvement were not ambulatory at the time of the procedure. Conclusions: Percutaneous laryngeal collagen augmentation is an effective treatment for parkinsonian hypophonia in a majority of patients. Patients with advanced neurologic disease with aphonia, difficulty with speech initiation, dysphagia, or ambulatory difficulty are less likely to respond to this procedure and should be so informed. (Otolaryngol Head Neck Surg 2002;126:653-656.)
A formulation and comparison of two linear feature selection techniques applicable to statistical classification

Abstract Odell and Decell and Coberly have given necessary and sufficient conditions for calculating the matrix of smallest dimension that will preserve the original Bayes classification regions when all population parameters are known. Tubbs et al. have given a solution to the problem of finding the smallest Bayes-classification-region-preserving dimension whenever the population parameters are unknown. This paper presents another solution to the problem and then compares the two solutions to the classical Wilks' method and two other recent methods using a Monte Carlo simulation. The SVD linear feature selection method proposed by Tubbs et al. performs the best over each of the configurations used in this Monte Carlo simulation study.
Incremental doses of intracoronary adenosine for the assessment of coronary velocity reserve for clinical decision making.

Achievement of maximal vasodilatation of the coronary microcirculation is a prerequisite for the measurement of coronary flow reserve (CFR). The present study was designed to address the hypothesis that intracoronary adenosine yields more complete vasodilation of the coronary microcirculation when incremental doses are used, resulting in higher and more accurate coronary flow reserve measurements. Four hundred and fifty-seven patients were divided in two groups; group I (319 patients) comprised patients without angiographic evidence of significant coronary artery disease, while group II (138 patients) comprised patients with intermediate coronary stenoses (between 40% and 70% diameter stenosis). Coronary velocity reserve (CVR, a surrogate measurement for CFR) was measured during cardiac catheterization using a Doppler-tipped guidewire. Incremental doses of intracoronary adenosine (12 to 54 microg for the left coronary artery and 6 to 42 microg for the right coronary artery) were administered. There was a significant difference between the initial dose of adenosine and the subsequent incremental doses. Of a total of 479 observations, only 192 (40%) had the maximal CVR value at the first dose. Thirty-nine percent of the patients in group I and 27% in group II with an initial CVR value or = 2.5 with incremental doses of adenosine. This study suggests that incremental doses of adenosine should be used to achieve maximal CVR for the assessment of the functional significance of coronary lesions. Cathet Cardiovasc Intervent 2001;54:34-40.
The factor V activating enzyme of Russell's viper venom

Abstract The factor V activator of Russell's viper venom is an arginine esterase and can be inhibited by diisopropylphosphorofluoridate. It has been shown that this enzyme accounts for one half the total coagulant activity of crude Russell's viper venom. The extent of activation of factor V by the venom factor V activator has been found to be the same as obtained using thrombin. In contrast to thrombin, however, the factor V activator neither clots fibrinogen nor does it catalyze proteolysis of prothrombin.
Efficiency of Japanese beetle (Coleoptera: Scarabaeidae) traps in reducing defoliation of plants in the urban landscape and effect on larval density in turf.

Although attractant traps are commonly used to protect ornamental and garden plants from defoliation by Japanese beetles ( Popillia japonica Newman), neither the utility of this practice nor its effect on larval density around traps has been investigated. In experiments on a golf course and in home landscapes, single traps positioned at 3.1 or 9.3 m upwind or downwind from test plants failed to reduce defoliation compared with that which occurred on plants without traps. In fact, defoliation was nearly always greater with a trap present. Surrounding a plant with three traps, each 9.3 m away, resulted in >90% defoliation within 30 h. Japanese beetle larval densities were not significantly altered in the vicinity of traps.
Chronic alcoholism and male sexual dysfunction

Chronic alcoholism can profoundly influence marital relationships, but the nature of the effect of alcohol abuse on sexual interactions is not clear. This article critically reviews information on the prevalence of sexual disorders and possible endocrine, neurologic, and psychologic processes that may mediate the effects of chronic alcoholism on male sexual functioning. Emphasis is placed on a conceptual model that integrates biologic and psychologic perspectives, moving away from simplistic unidimensional approaches to the study of the behavioral effects of this serious medical and social problem.
Application of31P nuclear magnetic resonance spectroscopy to investigate plasmid effects onEscherichia coli metabolism

Glucose metabolism inE. coli strain HB101, as a plasmid-free cell and as a host to two plasmids of different copy numbers, has been characterized using31P NMR. While the low-copy-number strain was found to behave very similarly to the plasmid-free strain, dramatically different behavior was exhibited by the high-copy-number strain. This strain maintained a nearly constant intracellular pH after addition of glucose to a starved suspension while intracellular pH of the other strains dropped considerably. The inorganic phosphate level in the high-copy-number strain was substantially higher than in the other strains, and the NTP level was much lower. Glycolytic rates of all three strains, however, were nearly identical. The trend in glycolytic rate strongly suggests that transport of glucose into the cell is the rate-limiting step under these conditions.
Clinical and morphological features of human hypertensive-diabetic cardiomyopathy

Abstract The existence of a specific cardiomyopathy secondary to diabetes mellitus is controversial. During a 2-year period, we had the opportunity to examine nine diabetic patients at autopsy who had clinically severe congestive heart failure and minimal extramural coronary artery atherosclerosis. Unexpectedly, all nine patients were found to be hypertensive. Accordingly, we initiated a detailed study of the clinical and morphological features of this group, and compared the findings to age-matched autopsied subjects with either isolated hypertension, isolated diabetes mellitus, or no heart disease. The study of the hypertensive-diabetic hearts revealed severe interstitial fibrosis, focal or confluent scars, and extensive myocytolytic activity. Comparison with the diabetic, hypertensive, and normal groups showed statistically significant differences in regard to the degree of interstitial and focal scarring, and the presence of myocytolysis. Only the hypertensive group had minimal interstitial scarring. There were no statistical differences in the small vessel changes between the four groups, although subjectively the hypertensive and hypertensive-diabetic patients had more severe disease. It is concluded that the association of diabetes mellitus and hypertension in the absence of significant coronary artery atherosclerosis may lead to a severe cardiomyopathy. Although the etiology of myocardial failure in this syndrome is uncertain, the degree of myocardial fibrosis and the frequency of myocytolytic lesions possibly related to catecholamine hypersensitivity, are potential explanations. Several studies suggesting that hypertension has adverse consequences in diabetes, as well as an animal model of hypertensive-diabetic cardiomyopathy, support our conclusion that cardiomyopathy associated with diabetes mellitus is a specific entity which may be secondary to the combined effects of diabetes and hypertension on the myocardium.
Family-Centered Practice with Single-Parent Families:

The author presents an ecological, family-centered approach to working with single-parent families. Using case examples, the author identifies four major issues resulting from divorce or separation that these families must confront. The article concludes with six practice principles for helping practitioners in their work.
Conodont color and textural alteration: an index to regional metamorphism, contact metamorphism, and hydrothermal alteration.

Experimental and field data are used to extend the utility of conodonts as semi-quantitative thermal indices into the regimes of regional and contact metamorphism, as well as hydrothermal alteration. An Arrhenius plot of data from induced conodont color alteration by pyrolysis in air at 1 atm was used to generate the geologic temperatures for conodont color-alteration indices (CAI) above 300 °C, that is, for CAI values of 5½ through 8. Such CAI values occur in very low- to medium-grade, regionally metamorphosed, contact-metamorphosed, and hydrothermally altered rocks. The uniformity or variability of CAI values within a sample, together with conodont texture, can help to distinguish grades and environments of metamorphism, particularly in metacarbonate sequences. Induced CAI by pyrolysis in a water-methane mixture at ½ kbar results in retardation of CAI and in a disparate mixture of both low and high CAI values within each experimental sample. In this system, color-alteration processes, above a CAI of 2 to 3, seem to change from predominantly carbonization to predominantly loss of organic matter, presumably by oxidation and volatilization of oxides. These experiments approximate the type of CAI mixture characteristically found in conodonts recovered from hydrothermally altered rocks. These data indicate that CAI values of 6 to 8 cannot be used to assess precise temperatures of hydrothermally altered rocks but may serve as useful indicators of potential mineralization.
Traveling wave effect on the seismic response of a steel arch bridge subjected to near fault ground motions

In the 1990s, several major earthquakes occurred throughout the world, with a common observation that near fault ground motion (NFGM) characteristics had a distinct impact on causing damage to civil engineering structures that could not be predicted by using far field ground motions. Since then, seismic responses of structures under NFGMs have been extensively examined, with most of the studies focusing on structures with relatively short fundamental periods, where the traveling wave effect does not need to be considered. However, for long span bridges, especially arch bridges, the traveling wave (only time delay considered) effect may be very distinct and is therefore important. In this paper, the results from a case study on the seismic response of a steel arch bridge under selected NFGMs is presented by considering the traveling wave effect with variable apparent velocities. The effects of fling step and long period pulses of NFGMs on the seismic responses of the arch bridge are also discussed.
Computers in early education: The child as theory builder

Children's use of computers to experiment and test ideas makes important contributions to their intellectual development, especially as they seek to construct theories about the nature of the physical world.
Molecular cloning of the cDNA for rat spleen thymosin β10 and the deduced amino acid sequence

A rat spleen cDNA library was prepared and employed for the molecular cloning of the cDNA for thymosin beta 10, a peptide that previously had been found to accompany the closely related peptide, thymosin beta 4, in several species of mammals (S. Erickson-Viitanen, S. Ruggieri, P. Natalini, and B. L. Horecker (1983) Arch. Biochem. Biophys. 225, 407-413). First-round screening with a synthetic oligodeoxynucleotide probe yielded 55 positive clones, and sequence analysis of 11 of these clones revealed that they all coded for a peptide containing the thymosin beta 10 sequence, except for an additional arginyl residue at position 39. This peptide, designated thymosin beta 10arg, had been identified previously in rabbit tissues and reported as a variant of thymosin beta 10 (S. Ruggieri, S. Erickson-Viitanen, and B.L. Horecker (1983) Arch. Biochem. Biophys. 226, 388-392). Analysis of the 55 positive clones using a specific oligodeoxynucleotide probe constructed to correspond to the mRNA sequence, including the codon for Arg39, confirmed that they all coded for the amino acid sequence including Arg39. Based on these results, the existence of a molecular species lacking Arg39 is considered unlikely, and we conclude that thymosin beta 10 contains 43, rather than 42, amino acid residues, with identity to thymosin beta 4 in 32 of the 43 residues. We propose that the name thymosin beta 10 be used to refer to the peptide containing Arg39 and that the designation thymosin beta 10arg be dropped. In the cDNA sequence the codons for Ala1 and Ser43 of thymosin beta 10 are flanked by initiator and terminator codons, respectively; thus, both the thymosin beta 4 and thymosin beta 10, which coexist in mammalian cells and tissues, are synthesized without the formation of larger polypeptide precursors.
Optimal Sampling Schemes for Estimating System Reliability by Testing Components—I: Fixed Sample Sizes

Abstract A Bayesian decision theoretic approach is employed to compare sampling schemes designed to estimate the reliability of series and parallel systems by testing individual components. Quadratic loss is assumed and schemes are found which minimize Bayes risk plus sampling cost. Several kinds of initial information concerning the reliability of the individual components, all of which assume the components function independently, are considered. The case for which the initial information is in terms of the system's reliability is briefly considered and related to the aforementioned case
State of the Hope: The New Bad Object in the Therapeutic Action of Psychoanalysis

Until recently, most psychoanalytic conceptualizations of the analyst as a new object have tended to equate newness with good experience and safety. Recent papers in the relational literature have explored not only the therapeutic value, but also the inevitability of the patient's experience of the analyst as bad, as well as the analyst's participation in this experience. This author examines the multifarious nature of hope, goodness, and badness in the clinical situation. The patient gets to know not only elements of his or her own self that are held by the analyst, but also ways in which the patient holds elements related to the particulars of the analyst's person in the analytic situation. Shifts in American psychoanalysis regarding conceptualizations of the analyst as a new object are examined. Limitations of a bifurcated approach to goodness and badness in clinical conceptualizations are also explored.
Residential Water Heating Dehumidifier (WHD) With Devoted Dehumidification

A new a dual-service dehumidifier water heater (WHD) appliance is being researched and developed by the authors. Prior research on a similar appliance, a heat pump water heater (HPWH), has demonstrated the unit’s increased performance and energy saving, and through collaboration, significant progress has been made toward developing the WHD into a potentially marketable product. The primary energy use in residential households is space conditioning (49%), and the second major energy use is hot water consumption. In DOE’s 2004 Buildings Data Book, 15.5 percent of residential energy utilization is consumed by water heating (DOE 2004, Table 1.2.3). The two major types of residential water heaters are direct gas fired (~55%) and electric resistance (~45%) (DOE 2004, Appliance Magazine 2005). The maximum efficiency of a standard electric resistance water heater is 1 (100%), and progress has been made to increase the efficiency of the current standard heaters to approximately 95 percent (DOE 2004, Table 5.10.6), which is roughly the maximum available with today’s technology. However, if the standard system is replaced by a Heat Pump Water Heater (HPWH), the performance can be increased by 140 percent (Zogg and Murphy 2004). The WHD operates as a HPWH while heating water and as a dedicated dehumidifier when water heating is not necessary. This paper presents the general design and laboratory testing results of a WHD. Preliminary performance data reveal coefficient of performances (COP) of approximately 2.2 during water heating. Further, market analysis has revealed that a potential need for this new technology is in regions with high humidity (Ashdown et al. 2004). These regions are primarily in the Northeast, Southeast and some coastal areas of the U.S. Current HPWH units do not have dedicated dehumidification and have a very small share of the residential water heat market. Of the 9.55 million residential water heaters sold in 2003 only about 2,000 of them were HPWHs (DOE 2004, Table 5.10.15).Copyright © 2005 by ASME
Infinitely Many Real Quadratic Fields of Class Number One

Abstract We point out that the results of Adleman and Huang ("Primality Testing and Abelian Varieties over Finite Fields," Lecture Notes in Math., Vol. 1512, Springer-Verlag, Berlin, 1992) imply that there are infinitely many real quadratic function fields over finite fields of ideal class number one. This is in marked contrast to the case of imaginary quadratic function fields over finite fields, of which there are four( J. Algebra 17 (1971), 243-261).
Binding Genre, Time, and Desire: Freud's construction of the Oedipus in the Interpretation of Dreams

(2000). Binding Genre, Time, and Desire: Freud's construction of the Oedipus in the Interpretation of Dreams. Psychoanalytic Studies: Vol. 2, No. 3, pp. 255-263.
DEA network computing in multi-stage parallel processes

DEA (Data Envelopment Analysis) is a managerial method that has been widely used for performance analysis in various public and private sectors. To deal with large-scale DEA problems, this research proposes the architecture of DEA network computing (LAN: Local Area Network) that is designed to coordinate a simultaneous use of multiple personal computers. An important feature of the proposed DEA computer architecture is that it is computationally structured in multi-stage parallel processes to enhance its algorithmic efficiency. The performance of the proposed network computing approach is tested and examined in a large simulation study.
Discovery of Small-Molecule Glucokinase Regulatory Protein Modulators That Restore Glucokinase Activity

In the nuclei of hepatocytes, glucokinase regulatory protein (GKRP) modulates the activity of glucokinase (GK), a key regulator of glucose homeostasis. Currently, direct activators of GK (GKAs) are in development for the treatment of type 2 diabetes. However, this approach is generally associated with a risk of hypoglycemia. To mitigate such risk, we target the GKRP regulation, which indirectly restores GK activity. Here we describe a screening strategy to look specifically for GKRP modulators, in addition to traditional GKAs. Two high-throughput screening campaigns were performed with our compound libraries using a luminescence assay format, one with GK alone and the other with a GK/GKRP complex in the presence of sorbitol-6-phosphate (S6P). By a subtraction method in the hit triage process of these campaigns, we discovered two close analogs that bind GKRP specifically with sub-µM potency to a site distinct from where fructose-1phosphate binds. These small molecules are first-in-class allosteric modulators of the GK/GKRP interaction and are fully active even in the presence of S6P. Activation of GK by this particular mechanism, without altering the enzymatic profile, represents a novel pharmacologic modality of intervention in the GK/GKRP pathway.
Computerized Axial Tomography in the Detection of Intraocular Foreign Bodies

CAT scanning was used in the localization of intraocular and periorbital foreign bodies in 36 consecutive patients. The method was found to be convenient, well-tolerated by the patient, and provided accurate and useful clinical information. Six cases are described to illustrate clinical situations where traditional localizing methods were unable to supply satisfactory information and where CAT scanning proved to be of significant assistance. This included uncooperative patients, multiple foreign bodies, anterior foreign bodies, and foreign bodies adjacent to the posterior scleral wall.
Organization and recall of related sentences by elderly and young adults.

Abstract Differences between elderly and young adults in storage organization of sentence material were investigated using a modification of Mandler's (1967) sorting technique. The elderly were expected to be relatively poorer at sorting organization, and would then recall less sentence material. The age groups were also compared on time taken to organize the sentences, recall organization, and performance on a short sentence comprehension test. There were no age differences in conceptual type of organization or clustering of sentences in sorting groups and recall storage organization was not related to the amount of recall. The elderly adults did require more time to acquire the sentences, and had lower recognition test scores. It was concluded that the sorting technique and measures related to it failed to detect the elderly adults' apparent difficulty in acquiring the sentences.
Nuclear Endings: Stopping War on Time

Preface The Theory of War Termination The Balance of Terror Command Systems and Nuclear War Termination Conflict Termination and the Problem of Surprise The Soviet View of War Termination War Termination and Extended Deterrence: U.S. and NATO Options in Europe Conflict Termination and U.S. Maritime Strategy Superpower Strategic Defenses, Deterrence, and War Termination Assessments and Future Prospects: U.S. Nuclear Strategy and Conflict Termination
Griev_Ing: Death Notification Skills and Applications for Fourth-Year Medical Students

Background and Purpose: Our study examined whether GRIEV_ING improved death notification skills of medical students, whether pretesting with simulated survivors primed learners and improved results of the intervention, and whether feedback on the simulated encounter improved student performance. Methods: GRIEV_ING training was given to 138 fourth-year medical students divided into three groups: exposure to simulated survivor (SS) with written feedback, exposure to SS but no feedback, and no exposure to SS before the training. Students were tested on self-confidence before and after the intervention and were rated by SSs on interpersonal communication and death notification skills. ANCOVA was performed, with gender and race covariates. Results: All groups improved on death notification competence and confidence at about the same rate. Competence significantly (p =.037) improved for the feedback group. Interpersonal communication scores declined for all groups. Conclusions: GRIEV_ING provides an effective m...
Lectures from the Voroshilov General Staff Academy

(1989). Lectures from the Voroshilov General Staff Academy. The Journal of Soviet Military Studies: Vol. 2, No. 2, pp. 157-171.
Preventable illness and out-of-area travel of children in New York counties.

The long-distance travellers could be important to any cost–benefit assessment of policies to increase or improve local resources. This study examines the out-of-area hospital admission pattern for patients with Ambulatory Care Sensitive (ACS) conditions, also known as preventable conditions. The availability of local resources play a significant role for hospitalization for these conditions. Despite a growing literature investigating hospital choice, little is known about the effects of resource availabilities in local areas and patient characteristics prompting people to seek care at a longer distance from home for these conditions. Based on hospital discharge data for New York residents (children) admitted to hospitals in New York, Pennsylvania, New Jersey or Connecticut in 1994, the study uses logistic regression to predict travel out of the local area for ACS admission. The actual distance between residence and hospital is a highly skewed and problematic measure, but the crossing of county boundaries is a related and very useful dichotomous measure of distant hospitalization. The study finds a strong association of types of insurance and availability of primary care with episodes of hospitalization for children outside the area of residence, after controlling for severity of illness and several other patient and county characteristics. Copyright © 2001 John Wiley & Sons, Ltd.
Antecedents and Consequences of Self-Verification: Implications for Individual and Group Development

This article presents an integrative, multilevel model of individual and group development. It extends a model of small group development that holds that self-verification—through self-disclosure and sharing feed-back—produces interpersonal congruence (group members seeing each other as they see themselves), which especially helps groups that are heterogeneous, working on tasks that require judgment, or both. The model presented here proposes that components of self-awareness—self-evaluation, confidence in self-other relationships, and self-development orientation—affect motivation for self-verification, and that leader and peer behavior, group facilitation, and one-on-one coaching and mentoring stimulate self-disclosure and feedback. Self-verification is proposed to encourage individuals and groups to set learning goals and value differences.
Disease and the depopulation of Hispaniola, 1492–1518∗

(1993). Disease and the depopulation of Hispaniola, 1492–1518. Colonial Latin American Review: Vol. 2, No. 1-2, pp. 213-245.
The Extended Branch-Arrow Model of the formation of retino-tectal connections

This paper presents XBAM (the Extended Branch-Arrow Model), a new model of the development of the retino-tectal topographic mapping as observed in frog, toad, and goldfish visual systems. The updating process employed by XBAM is distributed in nature and depends upon interactions between branches of retinal fibers, the branches and the boundaries of the tectum and grafts, and the branches and the tectal surface. Results of computer simulation of the model are related to experimental data obtained from tectal and retinal graft and lesion studies, and comparisons are also made with other models.
Toward classification of conformal theories

Abstract By studying the representations of the mapping class groups which arise in 2D conformal theories we derive some restrictions on the value of the conformal dimension hi of operators and the central charge c of the Virasoro algebra. As a simple application we show that when there are a finite number of operators in the conformal algebra, the hi and c are all rational.
Central San Andreas Fault: Strain Episodes, Fault Creep, and Earthquakes

Since March 1972, a number of earth-strain episodes have been recorded at the Stone Canyon Geophysical Observatory, San Benito County, California. The episodes closely resemble recordings of nearby fault-creep episodes in shape and duration, suggesting similar source mechanisms. The episodes occur during a period of high tectonic strain release, as evidenced by increased seismicity and an accelerated rate of fault creep. On September 3 and 4, 1972, a creep episode was followed (after 20 hr) by a local earthquake of magnitude 4.6, which generated a distinct strain step and was followed (after 5 to 10 min) by a strain episode.
Child-Rearing and Child-Care Practices among Israeli Students

To compare child-rearing practices cross-culturally, Cox ( 197 1 ) developed a 28-item questionnaire and used it in a study of Ethiopians. To enhance crosscultural comparability, the same questionnaire was given to comparable students: Chu and Ryback (1973) studied child-rearing practices in the Republic of China, and Ryback (1974) repeated the study in Thailand. To obtain information on child-care practices among the Hebrew population of Israel the same questionnaire was translated into Hebrew and administered to a sample of 150 predominantly Jewish Israeli students at Bar-Ilan University, living in the city of Tel Aviv. Although no statistical evaluation of the data from these studies was made, inspection of data suggests some aspects of child-rearing in Israel are remarkably similar to practices in other cultures, and some aspects are quite different. Among the Ethiopian, Chinese, Thai, and Israeli students, a greater proportion of Israeli students saw children as being made to feel loved and the parents as being sensitive to the child's needs. More Israelis appeared concerned about free urination and defecation by the young child and fewest appeared patient in training the child. More Ethiopian and Thai than Israeli and Chinese students (65% and 58% vs 30% and 29%, respectively) believed in the effectiveness of physical punishment. More Israeli students appeared to expect their children to become quickly independent of the family than any of the other three groups. More Israeli (46% yes, 50% no) than Ethiopian (22% yes, 73% no), Chinese (19% yes, 69% no) or Thai ( 5 % yes, 89% no) students were in general likely co allow aggressive behavior in children. More Israeli (54% yes, 42% no) and Ethiopian (46% yes, 54% no) than Chinese (16% yes, 69% no) students said they were likely to encourage fighting with other children.
Genetic and biosystematic studies on two new sibling species of Lycopersicon from interandean Perú.

All available accessions of the entity previously named “L. minutum” and described by Chmielewski were investigated biosystematically. All such lines can be unequivocally classified into two elements that are morphologically distinguished, chiefly by differences in flower size and exsertion of the stigma. The stigmas of the large-flowered type are strongly exserted; those of the smaller, slightly or not at all. Both forms are sporadically dispersed in the central and northern Peruvian Andes, east of the continental divide. They are sympatric and often cohabit in the Apurimac-Ayacucho-Cuzco region. Despite this overlap of ranges and intermingling, intermediate types have not been found in nature, although they can be produced experimentally by reciprocal crosses between the two forms. The F1 hybrids are highly fertile, but seeds produced by self-pollination germinate poorly.
An Unusual Variant of Chromosome 16 in Three Generations

An unusual variant of chromosome 16, 16p+, in three generations is described. This is the first clinical report of 16p+ in Japan.