cssi/SciSciGPT-SciSciNet huggingface dataset:
Design and Implementation of an Interdisciplinary Marketing/Management Course on Technology and Innovation Management

Given increasing industry demand for integrative learning, marketing curricula need to emphasize interdisciplinary approaches to teaching. Although team teaching is a useful method for achieving cross-functional integration, there are very few frameworks for effectively implementing team teaching. Consequently, marketing educators seeking to offer team-taught, interdisciplinary courses have little direction on how to proceed. Against this background, this article describes the design and implementation of a team-taught, Marketing/Management interdisciplinary course on Technology and Innovation Management (TiM). On the basis of their experiences with the course, the authors provide instructors with a template for effectively implementing similar courses.
How Religious Communities Affect Political Participation Among Latinos

Objective. We revisit several longstanding controversies in the study of how religion affects political participation among Latinos, examining the influence of religious affiliation, church attendance, and involvement in the “ancillary” activities of the church on three types of participation: voting, community problem solving, and contacting public officials. Methods. Data from the 2001 U.S. Congregational Life Survey and hierarchical methods are used to test a comprehensive model of religious influence. Results. We find that involvement in church small groups and other church-based activities that take place outside of the sanctuary hall consistently affect all political activities. Importantly, performing a leadership role within the church, or taking part in some other skill-building activity only affects our nonelectoral form of participation for Latinos, but boosts participation across the board in the full sample. Conclusions. Our study lends some much-needed empirical confirmation to associational theories of political participation, but also sounds a note of caution about the universal applicability of such theories. As the largest minority group in the United States, Latinos represent a key voting bloc that candidates from both political parties have eagerly tried to
Exonic Splicing Enhancer Motif Recognized by Human SC35 under Splicing Conditions

Exonic splicing enhancers (ESEs) are important cis elements required for exon inclusion. Using an in vitro functional selection and amplification procedure, we have identified a novel ESE motif recognized by the human SR protein SC35 under splicing conditions. The selected sequences are functional and specific: they promote splicing in nuclear extract or in S100 extract complemented by SC35 but not by SF2/ASF. They can also function in a different exonic context from the one used for the selection procedure. The selected sequences share one or two close matches to a short and highly degenerate octamer consensus, GRYYcSYR. A score matrix was generated from the selected sequences according to the nucleotide frequency at each position of their best match to the consensus motif. The SC35 score matrix, along with our previously reported SF2/ASF score matrix, was used to search the sequences of two well-characterized splicing substrates derived from the mouse immunoglobulin M (IgM) and human immunodeficiency virus tat genes. Multiple SC35 high-score motifs, but only two widely separated SF2/ASF motifs, were found in the IgM C4 exon, which can be spliced in S100 extract complemented by SC35. In contrast, multiple high-score motifs for both SF2/ASF and SC35 were found in a variant of the Tat T3 exon (lacking an SC35-specific silencer) whose splicing can be complemented by either SF2/ASF or SC35. The motif score matrix can help locate SC35-specific enhancers in natural exon sequences.
Auditory repetition priming is impaired in pure alexic patients.

Abstract Alexia without agraphia, or “pure” alexia, is an acquired impairment in reading that leaves writing skills intact. Repetition priming for visually presented words is diminished in pure alexia. However, it is not possible to verify whether this priming deficit is modality-specific or modality independent because reading abilities are compromised. Hence, auditory repetition priming was assessed with lexical decision and word stem completion tasks in pure alexic patients with lesions in left inferior temporal–occipital cortex and the splenium. Perceptually based, modality-specific priming models predict intact auditory priming, since auditory association cortex is spared in the patients. Alternatively, modality-independent models, which suggest that priming reflects the temporary modification of an amodal system, might predict impairments. Baseline performance was matched in the patients and controls, although lexical decision priming measures showed an interaction between group and repetition lag. The patients showed intact immediate priming but significantly less priming than controls at longer delays. Furthermore, word stem completion priming was abolished in the patients. One explanation for the deficit is that left inferior temporal–occipital cortex supports amodal aspects of priming, as suggested by recent neuroimaging results. Another possibility is that long-term auditory priming relies on covert orthographic representations which were unavailable in the patients. The results provide support for interactive models of word identification.
Experimental verification of acoustic saturation

The maximum value of acoustic pressure within an ultrasonic beam is limited by acoustic saturation. The theoretical basis for acoustic saturation has been analyzed previously. In this work, a high-power pulse source is used to drive acoustic pressure levels from an ultrasonic beam to saturation. An automatic procedure determines the field's beam axis using a calibrated Marconi PVDF hydrophone. The hydrophone measured RF waveforms are recorded along the beam axis and analyzed off-line. The peak compressional pressure is evaluated as a function of distance along the beam axis. The overall maximum pressure is compared to theoretical predictions. Three-, six-, and nine-MHz center frequency, 19-mm-diameter transducers were analyzed. The longer focal length transducer saturation level was comparable to a theoretical prediction. However, the theoretical saturation level for the shorter focal length transducers underestimated experimental results.
Identifying causal structure in a biological neural network

A simulator for the Burgess, Recce, and O'Keefe (1994) BRO model of rodent navigation was built. Initial experiments did not reproduce the navigation performance reported by BRO. To determine the cause of the discrepancy, we reconstructed and reanalyzed their model. We were able to verify their main claim that if phase-modulated place cells act as radial basis functions, then they computationally have the ability to support memory-based navigation. However, our simulations were unable to reproduce their model of hippocampal cell place field acquisition.
In Vitro and In Vivo Activities of Nitazoxanide against Clostridium difficile

We have used the hamster model of antibiotic-induced Clostridium difficile intestinal disease to evaluate nitazoxanide (NTZ), a nitrothiazole benzamide antimicrobial agent. The following in vitro and in vivo activities of NTZ in the adult hamster were examined and compared to those of metronidazole and vancomycin: (i) MICs and minimum bactericidal concentrations (MBCs) against C. difficile, (ii) toxicity, (iii) ability to prevent C. difficile-associated ileocecitis, and (iv) propensity to induce C. difficile-associated ileocecitis. The MICs and MBCs of NTZ against 15 toxigenic strains of C. difficile were comparable to those of vancomycin or metronidazole. C. difficile-associated ileocecitis was induced with oral clindamycin and toxigenic C. difficile in a group of 60 hamsters. Subgroups of 10 hamsters were given six daily intragastric treatments of NTZ (15, 7.5, and 3.0 mg/100 g of body weight [gbw]), metronidazole (15 mg/100 gbw), vancomycin (5 mg/100 gbw), or saline (1 ml/100 gbw). Animals receiving saline died 3 days post-C. difficile challenge. During the treatment period, NTZ (≥7.5 mg/100 gbw), like metronidazole and vancomycin, prevented outward manifestations of clindamycin-induced C. difficile intestinal disease. Six of ten hamsters on a scheduled dose of 3.0 mg of NTZ/100 gbw survived for the complete treatment period. Of these surviving animals, all but three died of C. difficile disease by between 3 and 12 days following discontinuation of antibiotic therapy. Another group of hamsters received six similar daily doses of the three antibiotics, followed by an inoculation with toxigenic C. difficile. All of the NTZ-treated animals survived the 15-day postinfection period. Upon necropsy, all hamsters appeared normal: there were no gross signs of toxicity or C. difficile intestinal disease, nor was C. difficile detected in the cultures of the ceca of these animals. By contrast, vancomycin and metronidazole treatment induced fatal C. difficile intestinal disease in 20 and 70% of recipients, respectively.
Roscovitine, a Specific Inhibitor of Cellular Cyclin-Dependent Kinases, Inhibits Herpes Simplex Virus DNA Synthesis in the Presence of Viral Early Proteins

We have previously shown that two inhibitors specific for cellular cyclin-dependent kinases (cdks), Roscovitine (Rosco) and Olomoucine (Olo), block the replication of herpes simplex virus (HSV). Based on these results, we demonstrated that HSV replication requires cellular cdks that are sensitive to these drugs (L. M. Schang, J. Phillips, and P. A. Schaffer. J. Virol. 72:5626–5637, 1998). We further established that at least two distinct steps in the viral replication cycle require cdks: transcription of immediate-early (IE) genes and transcription of early (E) genes (L. M. Schang, A. Rosenberg, and P. A. Schaffer, J. Virol. 73:2161–2172, 1999). Since Rosco inhibits HSV replication efficiently even when added to infected cells at 6 h postinfection, we postulated that cdks may also be required for viral functions that occur after E gene expression. In the study presented herein, we tested this hypothesis directly by measuring the efficiency of viral replication, viral DNA synthesis, and expression of several viral genes during infections in which Rosco was added after E proteins had already been synthesized. Rosco inhibited HSV replication, and specifically viral DNA synthesis, when the drug was added at the time of release from a 12-h phosphonoacetic acid (PAA)-induced block in viral DNA synthesis. Inhibition of DNA synthesis was not a consequence of inhibition of expression of IE or E genes in that Rosco had no effect on steady-state levels of two E transcripts under the same conditions in which it inhibited viral DNA synthesis. Moreover, viral DNA synthesis was inhibited by Rosco even in the absence of protein synthesis. In a second series of experiments, the replication of four HSV mutants harboring temperature-sensitive mutations in genes essential for viral DNA replication was inhibited when Rosco was added at the time of shift-down from the nonpermissive to the permissive temperature. Viral DNA synthesis was inhibited by Rosco under these conditions, whereas expression of viral E genes was not affected. We conclude that cellular Rosco-sensitive cdks are required for replication of viral DNA in the presence of viral E proteins. This requirement may indicate that HSV DNA synthesis is functionally linked to transcription, which requires cdks, or that both viral transcription and DNA replication, independently, require viral or cellular factors activated by Rosco-sensitive cdks.
NADPH oxidase: short-term foe, long-term friend.

in this issue of Journal of Applied Physiology , Nottin and colleagues ([9][1]) in their manuscript “β-Adrenergic receptors desensitization is not involved in exercise-induced cardiac fatigue: NADPH oxidase-induced oxidative stress as a new trigger,” examine the involvement of both β-
Analysis of the dynamics of adaptation to transgenic corn and crop rotation by western corn rootworm (Coleoptera: Chrysomelidae) using a daily time-step model

Western corn rootworm, Diabrotica virgifera virgifera LeConte, has overcome crop rotation in several areas of the north central United States. The effectiveness of crop rotation for management of corn rootworm has begun to fail in many areas of the midwestern United States, thus new management strategies need to be developed to control rotation-resistant populations. Transgenic corn, Zea mays L., effective against western corn rootworm, may be the most effective new technology for control of this pest in areas with or without populations adapted to crop rotation. We expanded a simulation model of the population dynamics and genetics of the western corn rootworm for a landscape of corn; soybean, Glycine max (L.); and other crops to study the simultaneous development of resistance to both crop rotation and transgenic corn. Results indicate that planting transgenic corn to first-year cornfields is a robust strategy to prevent resistance to both crop rotation and transgenic corn in areas where rotation-resistant populations are currently a problem or may be a problem in the future. In these areas, planting transgenic corn only in continuous cornfields is not an effective strategy to prevent resistance to either trait. In areas without rotation-resistant populations, gene expression of the allele for resistance to transgenic corn, R, is the most important factor affecting the evolution of resistance. If R is recessive, resistance can be delayed longer than 15 yr. If R is dominant, resistance may be difficult to prevent. In a sensitivity analysis, results indicate that density dependence, rotational level in the landscape, and initial allele frequency are the three most important factors affecting the results.
Part II. 1975–1978: Days at the Mother Library

This is the second installment in Robert Berring's autobiography, The Education of a Twentieth Century Law Librarian. The first installment is at 32 Legal Reference Services Quarterly 1 (2013).
QODI: Query as Context in Automatic Data Integration

QODI is an automatic ontology-based data integration system (OBDI). QODI is distinguished in that the ontology mapping algorithm dynamically determines a partial mapping specific to the reformulation of each query. The query provides application context not available in the ontologies alone; thereby the system is able to disambiguate mappings for different queries. The mapping algorithm decomposes the query into a set of paths, and compares the set of paths with a similar decomposition of a source ontology. Using test sets from three real world applications, QODI achieves favorable results compared with AgreementMaker, a leading ontology matcher, and an ontology-based implementation of the mapping methods detailed for Clio, the state-of-the-art relational data integration and data exchange system.
Monolithic Fill Tube Target Fabrication

Fielding a cryogenic ICF capsule for near-term ignition shots requires a fill-tube to deliver fuel to the capsule. Polymer capsules (0.9 and 3.1 mm o.d.) with a monolithic fill-tube have been produced. The fill tube is formed on the capsule by plasma polymer coating on a mandrel with a depolymerizable stalk. We report recent advances achieved in monolithic fill-tube capsule production. The micro-assembly station for attaching PAMS stalk to the mandrels was improved to reduce fillet and fill tube diameters and increase throughput. Excimer laser etching is used to micro-machine fill-tube capsules and target components to allow proper mating for assembly. The fill-tube target is attached to the gas source by a flexible polymer fill line and was tested to confirm gas flow and retention. The effect of the mandrel stalk on the uniformity of GDP coating is investigated.
Comments on Securities and Exchange Commission Re-Proposed Rules for Nationally Recognized Statistical Rating Organizations

The SEC's proposal that rating agencies be required to disclose 100% of their ratings actions in a publicly accessible format is a step in the right direction, especially in light of the dominant rating agencies' claims that their issuer-pays business model is justified on the ground that it facilitates public availability of ratings. The Commission should consider further steps, including (1) reduction of rating-dependent regulation - a proposal it took up and has apparently tabled or abandoned; (2) a regime that directly hold rating agencies accountable for their rating quality; and (3) alternatives to the issuer-pays business model. Although it may be the case that conflicts presented by issuer-pays can be managed effectively, as the dominant rating agencies claim, it would be irresponsible for the Commission not to engage in a rigorous and detailed analysis of the pros and cons of this business model, which it possesses the statutory authority to ban outright.
UniAlign: protein structure alignment meets evolution.

MOTIVATION During the evolution, functional sites on the surface of the protein as well as the hydrophobic core maintaining the structural integrity are well-conserved. However, available protein structure alignment methods align protein structures based solely on the 3D geometric similarity, limiting their ability to detect functionally relevant correspondences between the residues of the proteins, especially for distantly related homologous proteins. RESULTS In this article, we propose a new protein pairwise structure alignment algorithm (UniAlign) that incorporates additional evolutionary information captured in the form of sequence similarity, sequence profiles and residue conservation. We define a per-residue score (UniScore) as a weighted sum of these and other features and develop an iterative optimization procedure to search for an alignment with the best overall UniScore. Our extensive experiments on CDD, HOMSTRAD and BAliBASE benchmark datasets show that UniAlign outperforms commonly used structure alignment methods. We further demonstrate UniAlign's ability to develop family-specific models to drastically improve the quality of the alignments. AVAILABILITY AND IMPLEMENTATION UniAlign is available as a web service at: http://sacan.biomed.drexel.edu/unialign CONTACT ahmet.sacan@drexel.edu SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Exploiting hardware abstraction for hybrid parallel computing framework

Dedicated hardware modules on Field-Programmable Gate Arrays (FPGAs) are applied to achieve significant performance improvement over the software implementations. However, even in a simple system-on-chip (SoC) design on FPGA, hardware accelerators are managed explicitly by writing hardware/software interfaces. Programmers have to go through massive details to control and communicate with hardware accelerators, not to mention complicated functions to achieve memory allocation and hardware reuse. Besides, designing hardware accelerators still lacks productivity and flexibility. Promising data-level parallel applications can be accelerated by using recent parallel programming models. In this work, we extend software threads to hardware threads. By implementing a hybrid parallel computing framework the parallel applications are supported through the scheduling and reusing of the threads. Programmers can create software threads in an embedded OS environment without managing hardware details. Hardware manager takes over software threads and manage hardware resources in terms of reallocation and isolation. Experimental results demonstrate that hardware threads can achieve up to 10 times speedup over software implementation. The relationships between the length of scheduling time slices, and the performance and the response time are carefully evaluated. Besides, as the number of threads increases, the system demonstrates a good scalability.
THE MECHANISMS INVOLVED IN THE REMOVAL OF COLLOIDAL AND PARTICULATE CARBON FROM JOINT CAVITIES

1. Most of the carbon which was injected into the joint cavity was phagocytized by macrophages and leucocytes, and by the tenth day after the injection the greater part of it had been carried out of the joint cavity by these cells. 2. Small amounts of free carbon passed through the intact synovial surface. 3. The synovial lining cells took up small amounts of carbon and tended to hold the ingested carbon indefinitely. 4. A variable amount of carbon was held in fibrin clots which became attached to the synovial membrane and were invaded by cells which formed a new synovial membrane on the free surface of the clot. 5. A small amount of the free carbon was carried from the subsynovial tissues to the popliteal lymph node. 6. Most of the carbon remained in the loose tissues around the joint, and much of it was repeatedly phagocytized and moved about by succeeding generations of macrophages. 7. Living leucocytes were seen to expel ingested carbon but the macrophages apparently retained the material until the cell died and degenerated. 8. The various types of connective tissue and bone cells took up small amounts of carbon and tended to hold it indefinitely. 9. Some of the carbon which was injected into the joint was eventually transported into the femur, tibia, patella, and sesamoid bones. 10. The extracellular carbon in the subsynovial tissues was slowly absorbed as colloidal carbon and was carried by the blood stream to the reticulo-endothelial system.
How Private is Private Equity

Private equity funds enjoy a number of advantages: they avoid the informational requirements (and liabilities) that antifraud laws place on other funds, limited partners are less able to liquidate their shares, and the general partner has more autonomy. The benefit of these features is that they prevent the unwinding of optimal risk allocation between general and limited partners. This article argues that any new financial regulation should not disrupt this risk allocation but should instead expand investors’ opportunity to allocate risk, which would reduce the agency cost (and high fund manager compensation) that private equity funds now experience.
Ultra Violet Rotational Raman Spectroscopy with a Dispersive Atomic Resonance Filter

Rotational Raman cross sections of typical gases are one to two orders of magnitude larger than vibrational Raman cross sections, however, because the spacing of the rotational levels is very small (~1000 times less than the vibrational spacing), and because the manifold of rotational lines lies very near the much stronger Rayleigh line, most Raman measurements have focused on vibrational scattering.
Engineering Absorption Cross Section for Extraordinary Light Concentration

We show that engineering the radiation channels in a phase index near-zero materials can significantly overcome the isotropic limit of the optical cross section of a single nanoresonator to achieve extraordinary large cross section.
Efficacy of fenoxycarb against mosquitoes (Diptera: Culicidae) and its persistence in the laboratory and field.

Fenoxycarb is effective against susceptible and organophosphorus-resistant mosquitoes. When larvae are exposed, mortality occurs in the pupal stage or abnormal adults are formed. Most sensitive are fourth instars 19–27 h before pupation. A dosage of 0.02 kg/ha was effective for controlling larvae when applied by hand can or aircraft. Fenoxycarb is moderately stable in water over a pH range of 6.5–10 and a temperature range of 10–38°C. It tends to adsorb onto organic matter and this may largely limit its persistence in water in the fields. Residues in the water could only be detected up to 48 h after application of 0.03 or 0.02 kg/ha. Bluegill sunfish, Lepomis macrochirus , accumulate a continuous dose of 1 ppm fenoxycarb from water ca. 20-fold into their tissue; however, the tissue residues decline quickly after the fish are placed in untreated rinse water.
Differential effect of noradrenaline and renal nerve stimulation on vascular resistance in the dog kidney and the release of a prostaglandin E-like substance.

1. The concentrations of prostaglandin E(PGE)- and prostaglandin F(PGF)-like substances in renal venous blood were determined by parallel bioassay of extracts of renal venous effluent before and during adrenergic stimulation of the kidney and were related to simultaneous measurements of renal blood flow and urine flow. 2. When noradrenaline was infused continuously into the renal artery, its initial vasoconstrictor and antidiuretic effects diminished on seven of eight occasions in six dogs. Rapid recovery of renal blood flow and urine flow was invariably associated with increasing concentration in renal venous blood of a substance having the physicochemical, chromatographic and biological properties of a prostaglandin of the E series. In the one instance when rapid early recovery of renal blood flow was not observed the concentration of PGE-like substance was not increased. 3. In contrast, during renal nerve stimulation early rapid recovery of renal blood flow and urine flow did not occur and the concentration of a PGE-like substance in renal venous blood did not increase. The concentration of a PGF-like substance in renal venous effluent did not increase in response to either stimulus. 4. Since PGE 2 , unlike PGF 2α , is a potent renal vasodilator and diuretic, the intrarenal release of this substance by noradrenaline in concentrations similar to those determined for a PGE-like substance (>0·50 ng/ml assayed as PGE 2 equivalents) would account for the changes in renal blood flow and urine flow in these experiments when the renal actions of noradrenaline were attenuated. 5. These results support the proposal that renal prostaglandins function in an intrarenal negative feedback control system which regulates antidiuretic and vasoconstrictor systems.
MULTIPLE CLINICAL FACTORS AFFECT LEFT ATRIAL SHAPE IN ATRIAL FIBRILLATION

Multiple markers of left atrial (LA) structural remodeling, including LA shape, have been shown to be important in atrial fibrillation (AF). Statistical shape modeling (SSM) is a quantitative method for evaluation of shape, which we use to investigate clinical factors that affect LA shape in
Market Analysis: A Case Study:

AVORABLE electric rates in a given area are the first characteristics determining the market possibilities for electric ranges and electric storage water heaters. Adequate wiring, while applying only to specific buildings, designates the minimum electric supply equipment at the point of installation, and ranks next to favorable rates as a market influence. Unlike electric refrigerators, food mixers and other socket appliances effected only slightly by rates, the range and water heater present a highly specialized problem to commercial marketing which is directly concerned with basic public utility operating policies, transportation of solid fuel, laws of the several states regarding trade practices, "combination utilities" which have large gas property investments as well as electric operations, and several other fundamental economic factors which definitely remove these two products from the class of "plug-in" appliances requiring only a convenient "outlet." In I931 there were slightly more than 20 million meters installed in dwelling units in the United States, yet only eight million electric meters had rates low enough to permit electric range installations. By I94I there were 25 million electric meters and 24 million (96 per cent) had rates favorable for electric ranges. Three cents a kwh is considered favorable, and the 1941 national average was 2.2 cents per kwh. However, there are rates as low as one cent per kwh, so even though the utility industry has recognized the revenue value of this major appliance, our market study becomes more complicated because some rates are more "favorable" than others. The electric storage water heater found a favorable rate market later than the range, but has been developing even more rapidly during recent years. Only 23 per cent of the electric meters were available in I935. Today approximately 70 per cent of the meters have a rate suitable for operation of a storage water heater. Domestic meters with 1.5 cents per kwh. or less rate, are considered favorable. As mentioned, the foregoing may have the deceptive appearance of simplifying the market situation from the commercial research point of view. Actually, this rapidly shifting scene on the nation's basic domestic electric rates has caused complexities requiring increased intensity in market study. For example, each of the several hundred operating utilities across the nation has its own rate and operating policy. However, each of them does not necessarily serve an identifiable geographic area. The properties vary in size from village municipal plants with a diesel driven generator, to vast business managed systems serving millions of residential and thousands of industrial customers. While rates and service conditions are widely different, even between companies adjacent to one another, they are invariably determined by public bodies; and while they change, lower rates do not always mean a ready market for appliances. Adequate wiring for ranges and water
Sociological Concepts I: The Microscopic Level of Analysis

In this chapter we shall deal with some of the concepts basic to the field of sociology, with the aim of developing a general framework with which to analyse social behaviour in general and South African society in particular. Throughout this discussion it is most important to remember that both the concepts and the framework are simply analytical tools and are not explanatory in themselves. Thus, the danger of reification mentioned earlier must be avoided. Concepts such as ‘role’, #x2018;status#x2019;, and ‘social class’, cannot be used to explain social phenomena on their own and are not real entities. Used within the confines of a theoretical framework, however, they may be useful in the exploration of social behaviour. They also require clear and explicit definition before they are used in this manner.
Engineered Concrete: Mix Design and Test Methods, Second Edition

As every civil engineer knows, Portland Cement is the most versatile and important material of construction, and will probably remain so far into the future. Yet few books, if any, exist that offer an in-depth analysis of the mixing and testing methods of this vital hydraulic cement. This statement, written about the first edition of Engineere
FIRST REPORT OF DESERTOBIA ANKERARIA (STAUDINGER, 1861) (LEPIDOPTERA: GEOMETRIDAE) IN SERBIA

Desertobia ankeraria (Staudinger, 1861) is a Natura 2000 target species and it is included in Anex II of EEC 92/43 Habitat Directive. It is strictly protected species in Slovenia, Croatia and Hungary. It is recorded for the first time in Serbia in Pcinja river valley near Trgoviste at locality Vražji Kamen. The species was attracted to the light trap on March 15 th , 2016. D. ankeraria usually inhabits inhabits xerothermic oak woodlands and caterpillars are feeding on leaves of Downy Oak Quercus pubescens Wild. and Sessile Oak Q. petraea (Matt.) Liebl. Such habitat and Downy Oak were found at Vražji Kamen during our previous research in southern Serbia.
Every curriculum tells a story [e-commerce master's program]

The fallacy that many post-secondary curricula are optimized to facilitate student learning is exposed by a parable of creating a curriculum to teach dragon slaying. As an alternative model, the story-centered curriculum is introduced and an example of using this approach to redesign an e-commerce master's program is presented. Examples of the story-centered curriculum being used in both master's-level and high school are described.
Abstract 302: High throughput drug screening with engineered tumor spheroids

Physiologically relevant, in vitro cell-based models are important tools to identify effective anticancer drugs. Three-dimensional (3D) clusters of cancer cells, called tumor spheroids, mimic key characteristics of avascular tumors such as diffusion limitations and hypoxia, and hence serve as a relevant model for compound screening. Nevertheless, current spheroid formation techniques face difficulties to generate large number of uniform sized spheroids, conveniently maintain them in culture and biochemically analyze them using commercially available tools. To address this need, we developed a robotic, high throughput technology for three-dimensional culture of cancer cells that is simple to implement, produces consistent size spheroids in standard microwell plates, and allows convenient robotic media exchange and drug addition, and analysis of cellular responses using microplate readers. The technology is based on the use of an aqueous two-phase system. Cancer cells confined in a drop of the denser aqueous phase are robotically dispensed into a microwell containing the immersion aqueous phase. Cells remain within the drop at the bottom of the microwell and form a viable spheroid. We demonstrate the robust performance of this technology by evaluating the effect of two clinically used drugs against biologically aggressive skin cancer and triple negative breast cancer (TNBC) cells. Skin cancer spheroids treated with paclitaxel and cisplatin show dose-dependent decrease in cell viability, but with a greater resistance compared to the monolayer culture (2D) of cells (paclitaxel: LD50,3D = 178.5 nM, LD50,2D = 22.1 nM and cisplatin: LD50,3D = 131.7 μM and LD50,2D = 29.2 μM. TNBC cell monolayer and spheroids treated with cisplatin displayed a similar LD50 value of ∼13.1 μM. However, unlike the monolayer culture of TNBC cells that showed a dose-response to paclitaxel with LD50,2D = 8.0 nM, TNBC spheroids showed resistance to this drug, even at micromolar-scale concentrations, and maintained a high viability. In conclusion, our tumor spheroid technology enables quick and efficient generation of relevant tumor models in standard microplates to conveniently treat with chemical compounds and analyze. This technology allows investigating the efficacy of drug compounds against cancer cells and reveals cellular responses not captured with widely-used monolayer cultures. The ease of conducting and analyzing high throughput experiments will substantially reduce labor and cost, and expedite discovery of effective anti-cancer compounds with a physiologic tumor model. Citation Format: Stephanie Lemmo, Ehsan Aefi, Gary Luker, Hossein Tavana. High throughput drug screening with engineered tumor spheroids. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 302. doi:10.1158/1538-7445.AM2015-302
The cell biology of fibroblast cyclooxygenase.

We have prepared polyclonal antisera against sheep seminal vesicles cy-clooxygenase (COX) which cross-reacted with human COX. We employed this antisera in studies with human dermal fibroblast cultures to immunoprecipi-tate selectively the COX enzyme. Labeling of the cells with [35S]-methionine, solubilization of cellular COX followed by its immunoprecipitation, SDS-PAGE electrophoresis and fluorography enabled us to determine directly the synthetic rate of COX protein and its modulation by the monokine inter-leukin-1 (IL-1).
Investigating the correlation between radar backscatter and in situ soil property measurements

Abstract Utilizing remote sensing techniques to extract soil properties can facilitate several engineering applications for large-scale monitoring and modeling purposes such as earthen levees monitoring, landslide mapping, and off-road mobility modeling. This study presents results of statistical analyses to investigate potential correlations between multiple polarization radar backscatter and various physical soil properties. The study was conducted on an approximately 3 km long section of earthen levees along the lower Mississippi river as part of the development of remote levee monitoring methods. Polarimetric synthetic aperture radar imagery from UAVSAR was used along with an extensive set of in situ soil properties. The following properties were analyzed from the top 30–50 cm of soil: texture (sand and clay fraction), penetration resistance (sleeve friction and cone tip resistance), saturated hydraulic conductivity, field capacity, permanent wilting point, and porosity. The results showed some correlation between the cross-polarized (HV) radar backscatter coefficients and most of these properties. A few soil properties, like clay fraction, showed similar but weaker correlations with the co-polarized channels (HH and VV). The correlations between the soil properties and radar backscatter were analyzed separately for the river side and land side of the levee. It was found that the magnitude and direction of the correlation for most of the soil properties noticeably differed between the river and the land sides. The findings of this study can be a good starting point for scattering modelers in a pursuit of better models for radar scattering at cross polarizations which would include more diverse set of soil parameters.
Evolution and Bio-Inspired Design: Natural Limitations

Biomimetics is the incorporation of novel structures and mechanisms from nature into the design and function of engineered systems. Promotion of biomimicry has been justified on the basis that evolution has modified structures and functions in organisms to achieve optimal solutions and maximize performance. Such justifications reflect an incomplete understanding of evolution and constraints imposed on biology. Evolution is not a conscious or predictive process and does not drive toward perfection. Organisms are not optimal with regard to any one specific function. Where a biological feature will out-perform available technologies, these features can be targeted for assimilation into bio-inspired designs. For engineers and entrepreneurial investors interested in a biomimetic approach, an understanding of evolution and the limitations and constraints that have shaped biological organisms are necessary to avoid unsupportable and overzealous claims.
Pilot Backup Protection Based on Wireless Communication

The paper presents a back-up protection scheme for loop system from all types of fault based on the directional element. The traditional back-up protection schemes such as distance protection and overcurrent protection are not suitable for the loop system. This paper shows a novel back-up protection scheme using the wireless communication, when the main protection doesn't work, the scheme provides a precise back-up protection which makes the affected area relatively small. The negative sequence and positive sequence directional elements are used to determine the direction of fault current. The scheme is simulated by the Simulink software and validated by using commercial relays.
Children with Both Developmental and Behavioral Needs: Profile of Two Clinic Populations

Little has been written about evaluation and intervention services for children with a combination of behavioral and developmental needs. Two multidisciplinary clinic populations were compared, a traditional Developmental Disabilities (DD) clinic and a Behavioral-Developmental Problems (BDP) Clinic that had the additional services of a child psychiatrist. The BDP clinic children had lower IQ's and more severe overall behavioral problems than children in the traditional DD clinic, but differences were not statistically significant. Children with Attention Deficit Hyperactivity Disorder (ADHD) and other psychiatric diagnoses were referred to both clinics at comparable rates. The effort to involve qualified mental health professionals in all aspects of professional training and clinical service for the DD population should be accelerated.
THE MONETARY SYSTEM, TAXATION, AND PUBLICANS IN THE TIME OF CHRIST

The Jews used bars and rings of gold and silver as money prior to using coins. Syrian, Roman, and Jewish coins were used during the time of Christ. The Roman Government imposed a tremendous tax burden upon its subjects. The people of Israel also had to pay a tax to the temple. Publicans, or tax collectors, were well known for their corruption. Thus, the Jews had utter contempt for publicans. Christ paid his share of taxes and taught that it was right to do so even under the corrupt system of the Romans.
When I Dance My Walk: A Phenomenological Analysis of Habitual Movement in Dance Practices

In this article, I describe the experience of dancing-a-walk. My specific focus is on the shift that I perceive in my body when I dance-a-walk rather than functionally walking. Following a firstperson perspective, I demonstrate how my experience of practicing dancing-a-walk interrogates the habit of walking and makes it come alive again as an expression of the body. First, I show how the practice of dancing-a-walk challenges the dichotomy between abstract and concrete movement proposed by Maurice Merleau-Ponty in the Phenomenology of Perception. Indeed, dancing-a-walk is an example of a concrete and yet already abstract movement. Then, I turn to concepts such as habits and body memory. By identifying how the perception of my body changes when I dance everyday movements (i.e., walking) versus when I execute such movements functionally, I aim to develop a new perspective on and vocabulary for a phenomenological definition of concrete/abstract movements within the context of dance.
The virtuous self‐tolerance of virtual memory T cells

“Virtual” memory CD8 + T cells are a subset of immune cells produced by homeostatic mechanisms involving response to self‐antigens, raising the possibility that these cells could mediate autoimmunity. New work by Drobek et al demonstrates that virtual memory T cells are indeed favored by stronger T‐cell receptor signals but exhibit minimal autoreactivity while maintaining self‐tolerance.
LANGUAGE ACQUISITION, APHASIA, AND PHONOTACTIC UNIVERSALS

In this paper I will consider the nature of phonotactic markedness in the light of work in early first language phonotaxis. Then we will turn to work in progress on a particular family of aphasic word production errors, to recent studies of second language acquisition, and to instrumental phonetic work on perceptual aspects of phonotaxis. I think that all four of these areas of study, as well as slip of the tongue data, are fitting together to make a coherent explanatory approach to phonotactic universals, this paper is intended as a brief introduction to the nature of that approach.
Treating ocular hypertension to reduce glaucoma risk: when to treat?

When to treat the patient who presents with ocular hypertension has been a question that has ‘stumped’ the ophthalmic community for decades. Population-based studies and intervention trials have provided the basis for understanding why we consider treating such patients. Although the EGPS (European Glaucoma Prevention Study) did not demonstrate that reducing intraocular pressure (IOP) with dorzolamide prevented the onset of glaucoma compared with individuals receiving a placebo, the investigators of the OHTS (Ocular Hypertension Treatment Study) found that the treatment of ocular hypertension can be delayed with topical medication when treated patients were compared with an observation group. There are differences in inclusion criteria, study design and retention rates between the EGPS and the OHTS, which may have led to the discrepancies in outcomes between these two studies. These differences provide a basis for understanding the relevance of the findings of both trials to clinical practice. The clinician should consider key risk factors such as age, thin corneal thickness measurements, large cup-to-disc ratio and mean IOP when determining who should be treated. However, the ultimate decision of when to treat will be determined by other issues such as life expectancy, the general health of the patient and the number of risk factors. Clearly, the treatment of only high-risk patients with ocular hypertension should be considered.
Re-Visiting an Old Friend: Updating “The Soviet Communist” Chapter of “Four Theories of The Press” to Empower 21st-Century Media Professionals

What is perplexing about Four Theories of the Press (Siebert, Peterson & Schramm, 1956) is that it is difficult to situate the western media within any of the theories or examples. Ideally, it would be wonderful if American media systems conformed to the Libertarian or the Social Responsibility theories. Of the four – Authoritarian, Libertarian, Social Responsibility, and Soviet/Communist – the middle pair, Libertarian and Social Responsibility, most-idealize the objectives of media systems in a free, democratic society, and, at times, western media systems do embody some attributes of the two. In the spirit of John Nerone’s and his seven contributors 1995 update of Four Theories, this research aims to continue this academic conversation by further expanding one dimension of Four Theories – the challenge to modernize Marxist theory and bring it into the daily process of media management and practice as a way to energize media managers and professionals in the 21st century. The hermeneutical methodology of this analysis will draw from contemporary philosopher Hans-Georg Gadamer’s (1975) assertion that individual understanding is key to making sense of the ever-changing broader perspectives that arguably create larger truths.
Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1.

Summary SAMHD1 is a dNTP triphosphohydrolase (dNTPase) that impairs retroviral replication in a subset of non-cycling immune cells. Here we show that SAMHD1 is a redox-sensitive enzyme and identify three redox-active cysteines within the protein: C341, C350, and C522. The three cysteines reside near one another and the allosteric nucleotide binding site. Mutations C341S and C522S abolish the ability of SAMHD1 to restrict HIV replication, whereas the C350S mutant remains restriction competent. The C522S mutation makes the protein resistant to inhibition by hydrogen peroxide but has no effect on the tetramerization-dependent dNTPase activity of SAMHD1 in vitro or on the ability of SAMHD1 to deplete cellular dNTPs. Our results reveal that enzymatic activation of SAMHD1 via nucleotide-dependent tetramerization is not sufficient for the establishment of the antiviral state and that retroviral restriction depends on the ability of the protein to undergo redox transformations.
Improving Resiliency of Power Grids during Extreme Events

This paper presents results of an investigation concerning the resilience of power grids during extreme events such as storms or hurricanes. It considers availability of forecasts which will allow approximate estimation of paths where physical damage to equipment and facilities will be likely. Based on the identified lines which are most likely to be damaged in the next period, an optimal combination of load shedding and line switching actions are determined while taking into account the critical loads that need to be served with highest priority. Simulation results are presented using the IEEE 118-Bus system to illustrate the proposed strategy.