cssi/SciSciGPT-SciSciNet huggingface dataset:
Heterogeneity of adult human striated muscle tropomyosin

The amino acid sequences of the human skeletal muscle tropomyosins were elucidated. Of the three α-types identified, the major fraction (identical to the single myocardial species) differed by 23 and 25 amino acid residues from the two minor α-forms and by 42 residues from β-tropomyosin. The two β-components differed only by deletion of the C-terminal residue in the minor fraction. These sequences will facilitate analysis of tropomyosin from developmental and diseased states.
Religion and Politics in Gramsci: An Introduction

Little has been printed in English on Gramsci's sociology of religion, despite considerable work done in European languages, particularly Italian. Yet Gramsci wrote extensively on the subject as well as on the link of religion to hegemony, the best known of his concepts. The main aim of the article is to supply English readers with an introduction to the topic. This is done with direct reference to Gramsci's writings, particularly The Prison Notebooks, but also with the aid of the main French and Italian commentators. Gramsci's understanding of religion is bound up with the principal concern of his work: to understand the dynamics of power in society both in the past as well as in the present, with an aim to bringing about a socialist "intellectual and moral reformation." The article examines this key term and its link with religion in Gramsci's outlook, before proceeding to the key concepts for analyzing religion: the common sense, the religion of the people, philosophy, the religion of the intellectuals, folklore and hegemony. Gramsci's analysis of history as a study of the interplay between religion and social structure is then outlined. Finally, the writer concludes that there is much to be learned from Gramsci's method and conceptual framework if one is seeking to re-discover the link between religion and politics in social-structural analysis.
Review Essay Popular Music and Everyday Life: Three Styles of Scholarly Appreciation

Partant de l'idee que la musique populaire, dans la vie quotidienne, est en meme temps un objet commun et un facteur d'influence sociale puissant, l'A. propose quelques commentaires a propos de trois ouvrages recents (et de tres bonne qualite) qui traitent d'experiences de musique populaire tres differentes : la musique rock en general, le karaoke, et la musique autochtone dans la region Australie-Pacifique occidental. Selon l'A., ces ouvrages illustrent les forces et les faiblesses de trois disciplines - philosophie, communication, et ethnomusicologie/etudes sur la musique - dans leur approche de la musique populaire. Malgre la sophistication croissante des etudes sur la musique populaire, la relation affective entre le chercheur et ses gouts et experiences musicaux personnels est probablement plus lucide que jamais. En conclusion, l'A. discute brievement les implications de cette relation affective pour l'evolution de l'approche ethnographique de la musique populaire.
Surface topology of the stomach in man and the laboratory ferret.

A scanning electron microscopic study was undertaken on the normal surface ultrastructure of the laboratory ferret and man. The openings to the gastric pits were clearly demonstrable in both species and were sometimes branched into separate gastric or pyloric glands in the ferret. Fewer cells were interspersed between the foveolae in the ferret than in man. At high magnification, the surface architecture appeared identical in both man and the ferret, and the convex surface and polygonal boundaries of each cell were apparent. Each cell surface was uniformly covered with microvilli, as observed at high magnification in both species. Precipitated strands, globules, or flakes of mucus could be observed on the gastric surface, and mucus sometimes obscured observation of the microvilli. Evidence was not found for discharge of mucus from the surface epithelial cells in either man or the ferret.
Measurements of Energy and Angular Distributions of Secondary Electrons Produced in Electron-Impact Ionization of Helium

The energy and angular distributions of electrons produced in the ionization of helium by electrons with energies between 100 eV and 2 keV have been measured in a crossed-beam apparatus consisting of a fixed hemispherical energy analyzer and a rotatable electron gun. Distributions of secondary electrons (those electrons departing with energies less than one-half that of the incident primary electrons) were obtained for a wide range of energies and for angles between 30\ifmmode^\circ\else\textdegree\fi{} and 150\ifmmode^\circ\else\textdegree\fi{} with respect to the direction of the incident primary electron beam. The observed angular distributions were significantly different from the results of two early electron-impact measurements; however, they agreed to the extent expected with more recent results and with similar proton-impact data. For secondary energies above about 50 eV and for primary energies greater than 300 eV, the energy distributions (the cross sections integrated over angle) were observed to be very nearly equal to the distribution given by the Mott formula for free-electron-free-electron scattering multiplied by the number of electrons in the target.
Web‐Based Interactive Courseware for Structural Steel Design Using Java

The recent resurgence of the World Wide Web and Internet technologies has provided fresh opportunities to enhance the educational environment. Issues in developing courseware for Web-based education and potential solutions are discussed. Building on the synergistic human-machine approach of interactive computer-aided design developed by Adeli in 1987, a new Web-based approach and courseware are presented to complement teaching of structural steel design. The courseware has been developed in Java, an object-oriented, platform-independent computer language. Example applets for interactive design of beams and different types of connections are presented. The user can modify or limit any design parameter and request a new design without the need to start all over again. This is an effective tutorial feature considering the open-ended nature of the design problems. The student can find the answers to a lot of what-if scenarios in a very short period of time. Not only does this boost the learning experience in the design course significantly, but it also makes it more interesting.
Novel protein RGPR-p117: its role as the regucalcin gene transcription factor.

RGPR-p117 was originally discovered as a novel protein that binds to a nuclear factor I (NFI) consensus motif TTGGC(N)6CC, which is present in the 5′-flanking region of the regucalcin gene (rgn). RGPR-p117 has been identified in human, rat, mouse, bovine, rabbit, and chicken livers. Phylogenetic analysis of six vertebrates shows that RGPR-p117 appears to form a single cluster, indicating a common evolutionary relationship of the RGPR-p117 family. The RGPR-p117 gene consists of at least 26 exons spanning approximately 4.1 kbp and is localized on human chromosome 1q25.2. RGPR-p117 mRNA is expressed in the liver, kidney, heart, spleen, and brain of rats. RGPR-p117 mRNA expression is stimulated through signaling mechanisms. Mammalian RGPR-p117 conserves a leucine zipper motif, which is present in many gene regulatory proteins. RGPR-p117 has been shown to translocate from the cytoplasm to the nucleus in NRK52E cells, a process which is mediated through protein kinase C signaling following hormonal stimulation. The phosphorylated RGPR-p117 binds to the TTGGC motif in the promoter region of the regucalcin gene and enhances regucalcin mRNA expression in the cells, indicating a role as a transcriptional factor. RGPR-p117 is also localized in the plasma membranes, nucleus, mitochondria, microsomes, and cytoplasm. Overexpression of RGPR-p117 has been found to induce a significant decrease in protein and DNA contents in cells, suggesting that RGPR-p117 may regulate the gene expression of other related proteins as well as the transcription factor. Also, overexpression of RGPR-p117 has a suppressive effect on cell death by inhibiting the gene expression of caspase-3, caspase-8, and Fas-associating death domain protein whose TTGGC motif is present in the promoter region of their genes. The novel protein RGPR-p117 has been shown to play an important role as a transcription factor.
Why Won't You Do What I Want? The Informative Failures of Children and Models.

Computational models are powerful tools – too powerful, according to some. We argue that the idea that models can “do anything” is wrong, and describe how their failures have been informative. We present new work showing surprising diversity in the effects of feedback on children’s task-switching, such that some children perseverate despite this feedback, other children switch as instructed, and yet others play an “opposites” game without truly switching to the newly-instructed task. We present simulations that demonstrate the failure of an otherwise-successful neural network model to capture this failure of children. Simulating this pattern motivates the inclusion of updating mechanisms that make contact with a growing literature on frontostriatal function, despite their absence in extant theories of the development of cognitive flexibility. We argue from this and other examples that computational models are more constrained than is typically acknowledged, and that their resulting failures can be theoretically illuminating.
Prediction of multinomial probability of land use change using a bisection decomposition and logistic regression

Land use change is an important research area in landscape ecology and urban development. Prediction of land use change (urban development) provides critical information for making the right policies and management plans in order to maintain and improve ecosystem and city functions. Logistic regression is a widely used method to predict binomial probabilities of land use change when just two responses (change and no-change) are considered. However, in practice, more than two types of change are encountered and multinomial probabilities are therefore needed. The existing methods for predicting multinomial probabilities have limits in building multinomial probability models and are often based on improper assumptions. This is due to the lack of proper methodology and inadequate software. In this study, a procedure has been developed for building models to predict the multinomial probabilities of land use change and urban development. The foundation of this procedure consists of a special bisection decomposition system for the decomposition of multiple-class systems to bi-class systems, conditional probability inference, and logistic regression for binomial probability models. A case study of urban development has been conducted to evaluate this procedure. The evaluation results demonstrated that different samples and bisection decomposition systems led to very similar quality and performance in the developed multinomial probability models, which indicates the high stability of the proposed procedure for this case study.
DEMONSTRATION TO MEDICAL STUDENTS OF PLACEBO RESPONSES AND NON-DRUG FACTORS

Abstract A class experiment for medical students Summary was devised to demonstrate the influence of the placebo effect and non-drug factors on response to drugs. The subjects were conditioned to expect sedative or stimulant effects, but all received placebo in one or two blue or pink capsules. Predictions about the size and nature of the placebo response and influence of the non-drug factors were made before the experiment and discussed afterwards. Four of six predictions were fully confirmed. Drug- associated changes were reported by 30% of the subjects and were severe in 1 or 2 individuals. Two capsules produced more noticeable changes than one, and blue capsules were associated with more sedative effects than pink capsules. Students rated the experiment highly both as a learning experience and for its relevance to their future practice of medicine.
Evidence for ineffective erythropoiesis in severe sickle cell disease.

Peripheral destruction of sickled erythrocytes is a cardinal feature of sickle cell disease (SCD). Less well established is the potential contribution of ineffective erythropoiesis to the pathophysiology of this hemoglobinopathy. Since patients with SCD frequently develop mixed hematopoietic chimerism after allogeneic nonmyeloablative stem cell transplantation, we used this opportunity to directly compare the differentiation and survival of SCD and donor-derived erythropoiesis in vivo. Donor and recipient erythropoiesis was compared in 4 patients with SCD and 4 without SCD who developed stable mixed hematopoietic chimerism following transplant. Molecular analysis of chimerism in peripheral blood and bone marrow demonstrated higher expression of donor-derived β-globin RNA relative to the level of donor-derived genomic DNA in patients with SCD. Analysis of chimerism in immature (glycophorin A–positive [GYPA+], CD71hi) and mature (GYPA+, CD71neg) erythroblasts confirmed the intramedullary loss of SS erythroblasts with progressive maturation. In patients with SCD, relative enrichment of donor erythroid precursors began to appear at the onset of hemoglobinization. Ineffective erythropoiesis of homozygous hemoglobin S (SS) progenitors thus provides a maturation advantage for homozygous hemoglobin A (AA) or heterozygous hemoglobin S/hemoglobin A (SA) donor erythroid precursor cells that results in greater donor contribution to overall erythropoiesis following stem-cell transplantation and improvement of clinical disease.
Chlorosis and meristem dieback in greenhouse‐grown asparagus transplants

Abstract Following observation of severe chlorosis and dieback of meri‐stem tissue in asparagus seedlings started in the greenhouse in a soilless media, a study was conducted to determine if the growth patterns were associated with one or more of the media components. Asparagus seedling growth using several potting media was compared. Treatments included single component media, washed sand, perlite, peat, Plainfield loamy sand [a local soil (PLS)], plus 1: 1 mixtures of peat/perlite, washed sand/peat, PLS/perlite, washed sand/peat, and PLS/peat. Abnormal growth patterns were observed in several of the media. Chlorosis was associated with high pH which occurred in perlite, washed sand, and their combinations. Chlorotic plants were characterized by low root and fern dry weights and low fern to root ratios. Meristem dieback occurred in several media treatments and did not appear to be pH related. Plants exhibiting dieback had fern to root ratios approaching 1 if they were not also affected by chlorosis. Nutr...
Normal eulerian clique-covering and hamiltonicity

A connected graph is hamiltonian if it contains a cycle which goes through all vertices exactly once. Determining if a graph is hamiltonian is known as an NP-complete problem and no satisfactory characterization for these graphs has been found. Since the seminal work of Dirac in 1952 many sufficient conditions were found. In 1974, Goodman and Hedetniemi gave such a condition based on the existence of a clique-covering of the graph. This condition was recently generalized using the notion of eulerian clique-covering. In addition, an algorithm able to find a normal eulerian clique-covering for a large class of graphs was also introduced. A normal clique-covering has additional properties, making the search for such a covering easier than in the general case. In this article, we prove several properties of normal clique-coverings. In particular we prove that there exists an eulerian clique-covering of a graph if and only if there exists a normal one. Using this result, the search for an eulerian clique-covering as a sufficient condition for hamiltonicity can be reduced to the normal case.
Consolidation-Induced Solute Transport for Constant Rate of Strain. II: Comparison with Incremental Loading

AbstractThis paper presents a numerical investigation of one-dimensional large strain consolidation-induced solute transport for incremental loading (IL) and constant rate of strain (CRS) conditions. Solute transport accounts for advection, diffusion, dispersion, linear and nonlinear sorption, and equilibrium and nonequilibrium sorption, and is consistent with temporal and spatial variations of porosity and seepage velocity in the consolidating soil. Simulations were conducted using material properties for kaolinite clay and indicate that IL and CRS conditions produce significantly different responses during the course of consolidation, including applied stress, rate of settlement, excess pore pressure, and local strain. However, for a given set of initial and boundary conditions, final solute mass outflows and final solute concentration profiles for IL and CRS conditions were generally in close agreement, provided that total elapsed time and final average strain were matched for both loading procedures. ...
The health-related quality of life of children with an extremity fracture: a one-year follow-up study.

PURPOSE: To document the health-related quality of life (HRQOL) of children with an extremity fracture at 3 and 12 months postinjury and to determine whether it varies significantly by fracture region and site. METHODS: Children hospitalized for an extremity fracture at 4 pediatric trauma centers were studied. A baseline, 3-month, and 12-month telephone interview were completed by a primary caregiver to measure the child's HRQOL using the Pediatric Quality of Life Inventory (PedsQL). HRQOL was modeled as a function of injury, patient, and family characteristics using a longitudinal regression model. RESULT: Of the 100 children enrolled, 52 sustained a lower extremity fracture (LEF) and 48 an upper extremity fracture (UEF). Postinjury HRQOL scores were significantly poorer than preinjury scores for all subjects (P = 0.05). In addition, a significant proportion of subjects reported impaired physical and psychosocial HRQOL at 3 (44% and 46%, respectively) and 12 months (23% and 33%, respectively) postinjury. At 3 months postinjury, children with an LEF had significantly poorer HRQOL outcomes compared to children with a UEF. By 12 months postinjury, the physical function of children with a tibia and/or fibula fracture remained significantly lower than children with a UEF (P < or = 0.05). CONCLUSIONS: Children hospitalized for an extremity fracture suffered dramatic declines in physical and psychosocial well-being during the first 3 months postinjury. By 1 year postinjury, most children recovered; however, children with a tibia and/or fibula fracture still reported significantly poorer physical functioning.
Hypoxia-induced changes in Ca2+ mobilization and protein phosphorylation implicated in impaired wound healing

The process of wound healing must be tightly regulated to achieve successful restoration of injured tissue. Previously, we demonstrated that when corneal epithelium is injured, nucleotides and neur...
Exceptional Cases: Epistemic Contributions and Normative Expectations

Exceptional cases are at odds with the typical: they stand out as bizarre and rare. What then could justify their systematic analysis? Elaborating the analytical distinction between anomalies, exceptions and outliers, this paper outlines three potential epistemic contributions of exceptional cases. First, exceptional cases reveal the limits of standard classification categories. In so doing, they problematize usual classificatory grids. Their input is critical. Second, exceptional cases point to new classes of objects. They acquire paradigmatic status when they exemplify the characteristic features of these new classes with utmost clarity. Third, exceptional cases magnify relational patterns that in more mundane contexts lack visibility. Here their contribution is heuristic. These three contributions become possible when we put at bay normative expectations of what should happen, and specify cases by reference to an analytical space of constitutive dimensions. To underscore the general significance of these observations, I draw on examples borrowed from different quarters of the social sciences: the sociology of organizations, ethnomethodology, comparative historical sociology and the history of science.
Reduction of GPS Noise for Precision Control of Robot Navigation in Confined Areas

Most modern navigation systems solve the localization problem by extensively using global positioning system (GPS) data. Unfortunately the GPS data quality depends on several factors, which can lead to large positioning errors. Known GPS errors fall in two groups: either atmospheric errors, or multipath errors. Because of these errors, differential GPS systems have been developed using both ground based and satellite based reference systems. The cost of a differential GPS unit such as a Novatel range from a little over $2000 to over $9000, which can be prohibitive for use on certain home service robotic vehicles such as autonomous snow plows or autonomous lawn mowers. This paper discusses ways of mitigating GPS errors on low cost single frequency GPS units such as Copernicus II, Skytraq and U-Blox, which cost far less than $100 each, and hence are attractive for use in many robotic applications such as those mentioned above. The paper will present a model of GPS noise and use that model to process GPS data for use in navigation of an autonomous snow plow designed for use in residential driveways and side-walks; it will be supported by experimental results only.Copyright © 2014 by ASME
Active control of smart structures with optimal actuator and sensor locations

ABSTRACT Sensors and actuators used in active control of smart structures have to be located appropriately in order to ensuremaximum control and measurement effectiveness. Many placement techniques are based on the structure itself andoverlook the effects of the applied control law. The optimal locations determined from open-loop system can notguarantee the best performance of the closed-loop system because the performance is closely related with the designrequirements and applied controller. In this paper, we presented a method of obtaining the optimal locations of actuators/sensors by combining the open-loop and closed-loop optimal criterions. First, for open-loop system, location indices ofthe controlled modes are calculated on the basis of modal controllability and observability. The controlled modes areweighted based on the controller design requirements. To reduce the Ospill-overO effect of uncontrolled modes, thelocation index values of uncontrolled modes are added as penalty terms. Locations with high index values are chosen ascandidate locations of actuator/sensor for the next determining step on the closed-loop system. Three control techniques,optimal , norms and optimal pole-placement, are utilized for two different control objectives, disturbance rejectionand damping property enhancement. Linear matrix inequality (LMI) techniques are utilized to formulate the controlproblems and synthesize the controllers. For each candidate location of actuator/sensor, a controller is designed and theobtained performance is taken as location index. By solving the location problem in two steps, we reduced thecomputational burden and ensured good control performance of the closed-loop system. The proposed method is tested ona clamped plate with piezoelectric actuators and sensors.Keywords : Optimal actuator/sensor locations, modal controllability and observability, optimal and controls,optimal pole-placement control, clamped plate, linear matrix inequality.
Buckling and Initial Postbuckling Behavior of Oval Cylindrical Shells Under Axial Compression

Buckling and initial postbuckling behavior of thin elastic cylindrical shells of elliptical cross section
Compressive adaptation of large steerable arrays

We consider the problem of adapting very large antenna arrays (e.g., with 1000 elements or more) for tasks such as beamforming and nulling, motivated by emerging applications at very high carrier frequencies in the millimeter (mm) wave band and beyond, where the small wavelengths make it possible to pack a very large number of antenna elements (e.g., realized as a printed circuit array) into nodes with compact form factors. Conventional least squares techniques, which rely on access to baseband signals for individual array elements, do not apply. Hence the preferred approach is to perform radio frequency (RF) beamsteering, with a single complex baseband signal emerging from a receive array, or going into a transmit array. Further, we are interested in what can be achieved with coarse-grained control of individual elements (e.g., four-phase, or even binary phase, control). In this paper, we propose an adaptation architecture matched to these hardware constraints. Our approach comprises the following two steps. The first step is compressive estimation of a sparse spatial channel using a small number of measurements, each using a different set of randomized weights. However, unlike the standard compressive sensing formulation, we are interested in estimating continuous-valued parameters such as the angles of arrivals of various paths. The second step is quantized beamsteering, where weights for beamforming and nulling, subject to the constraint of severe quantization, are computed using the channel estimates from the first step. We provide promising preliminary results illustrating the efficacy of this approach.
MicroRNAs as genetic sculptors: fishing for clues.

microRNAs (miRNAs) encode small RNA molecules of ∼22nts in length that regulate the deadenylation, translation, and decay of their target mRNAs. The identification of miRNAs in plants and animals has uncovered a new layer of gene regulation with important implications for development, cellular homeostasis and disease. Because each miRNA is predicted to regulate several hundred genes, a major challenge in the field remains to elucidate the precise roles for each miRNA and to understand the physiological relevance of individual miRNA–target interactions in vivo. Despite the wide variety of biological contexts where miRNAs function, a common theme emerges, whereby miRNAs shape gene expression within both spatial and temporal dimensions by removing messages from previous cellular states as well as modulating the levels of actively transcribed genes. This review will focus on the role that the teleost Danio rerio (zebrafish) has played in shaping our understanding of miRNA function in vertebrates.
Orbital computed tomographic characteristics of globe subluxation in thyroid orbitopathy

Abstract Objective Axial globe subluxation may complicate thyroid orbitopathy. This acute event is defined by anterior displacement of the globe equator beyond the orbital rim, lid retraction behind the equator, and tethering of the optic nerve. The authors explored the factors leading to spontaneous globe subluxation in patients with thyroid orbitopathy. Design A clinical review. Main outcome measures The medical charts and axial and coronal orbital computed tomographic (CT) scans of all the patients with spontaneous globe subluxation were reviewed. The patients were categorized according to their CT scans into type I ("lipogenic" variant) or type II ("myogenic" variant). Results Four (0.1%) of approximately 4000 patients with thyroid orbitopathy presented with spontaneous globe subluxation. All of these patients had increased orbital fat without significant enlargement of the extraocular muscles. Thus, they represent type-I thyroid orbitopathy. Conclusions Globe subluxation in thyroid orbitopathy requires compliance of the orbital soft tissues and extensibility of the extraocular muscles. These are characteristics of type-I orbitopathy. The increased fat content results in more compliance of the soft tissues, and the normal caliber of the muscles allows them to become more extensible. This permits the acute contraction of the eyelids posterior to the equator of the globe. Patients with type-I orbitopathy and extensive proptosis may be at relatively greater risk of having globe subluxation develop.
Long-term retention of transient news events.

Many retrospective analyses of remote memory have demonstrated recency effects in that memory for events proximal to the time of testing is superior to memory for events from remote time periods. However, the rate at which information decays over time and the specific pattern of forgetting may vary depending upon the distinct attributes of stimuli used as indices of memory. Studies examining long-term forgetting of well rehearsed, conceptually integrated information underscore preservation of remote events, some of which are thought to be permanently stored in memory. A different pattern of forgetting emerges in relation to recall of discrete facts whereby recall declines according to a negatively accelerated decay curve. In the current study long-term retention of transient news events was examined. Results were examined in relation to the effects of age and sex. All age groups demonstrated recency effects in that events from the recent past were recalled better than remote events. Age did not exert a negative influence on recall of remote or recent events with the exception of younger participants who did not recall items predating their dates of birth. Older female participants were less adept at recalling very old events than their male counterparts. (JINS, 2000, 6, 44–51.)
Two-dimensional characterization of atmospheric profile retrievals from limb sounding observations

Limb sounders measure atmospheric radiation that is dependent on atmospheric temperature and constituents that have a radial and angular distribution in Earth-centered coordinates. In order to evaluate the sensitivity of a limb retrieval to radial and angular distributions of trace gas concentrations, we perform and characterize one-dimensional (vertical) and two-dimensional (radial and angular) atmospheric profile retrievals. Our simulated atmosphere for these retrievals is a distribution of carbon monoxide (CO), which represents a plume off the coast of south-east Asia. Both the one-dimensional (1D) and two-dimensional (2D) limb retrievals are characterized by evaluating their averaging kernels and error covariances on a radial and angular grid that spans the plume. We apply this 2D characterization of a limb retrieval to a comparison of the 2D retrieval with the 1D (vertical) retrieval. By characterizing a limb retrieval in two dimensions the location of the air mass where the retrievals are most sensitive can be determined. For this test case the retrievals are most sensitive to the CO concentrations about 2° latitude in front of the tangent point locations. We find the information content for the 2D retrieval is an order of magnitude larger and the degrees of freedom is about a factor of two larger than that of the 1D retrieval primarily because the 2D retrieval can estimate angular distributions of CO concentrations. This 2D characterization allows the radial and angular resolution as well as the degrees of freedom and information content to be computed for these limb retrievals. We also use the 2D averaging kernel to develop a strategy for validation of a limb retrieval with an in situ measurement.
Influence of increased survival in very low birth weight, low birth weight, and normal birth weight infants on the incidence of sudden infant death syndrome in the United States: 1985-1991

Abstract Objective: To examine the relationship between infant survival and the rates of sudden infant death syndrome (SIDS) in very low birth weight (VLBW), low birth weight (LBW), and normal birth weight (NBW) infants from 1985 to 1991. Methods: The National Center for Health Statistics Birth Cohort Linked Birth/Infant Death Data Sets were used to determine birth weight, age at death, and cause of death for US-born singleton infants with birth weights of 500 g or more. Results: Increasing infant and postneonatal survival rates were greatest in VLBW infants. In contrast, SIDS rates did not change in VLBW infants (3.66 to 3.69; P = .70) but declined in both LBW (3.51 to 3.32; P = .041) and NBW (1.07 to 1.03; P = .008) infants. Postneonatal SIDS rates (per 1000 neonatal survivors) did not change in VLBW (4.93 to 4.58; P = .58) or LBW (3.36 to 3.22; P = .07) infants but declined in NBW infants (1.00 to 0.97; P = .018). Although there were differences among the slopes of survival rates, there was no statistical evidence of differences in the slope of SIDS rates among the three groups. Conclusions: The marked increase in survival of VLBW infants increased the pool of babies at potential risk for SIDS. VLBW infants' SIDS rates have not changed while they have declined in NBW and LBW infants. (J Pediatr 1998;133:73-8)
Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the pravastatin limitation of atherosclerosis in the coronary arteries (PLAC-I) trial

Abstract Lipoprotein subclass measurements may enhance the prediction of coronary artery disease (CAD) risk, but clinical application of such information has been hindered by the relatively laborious and time-consuming nature of laboratory measurement methods. In this study, lipoprotein subclass analyses were performed on frozen plasma samples from 241 participants in the Pravastatin Limitation of Atherosclerosis in the Coronary arteries Trial using an automated nuclear magnetic resonance technique. The objective was to determine if levels of these subclasses provided additional information on the progression of CAD, based on the change in the minimum lumen diameter, over a 3-year period. After adjustment for race, sex, age, treatment group, baseline lumen diameter, and chemically measured levels of triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol, on-trial predictors (p
Floating call boys and agile homosexuals: homophobia/Venice/history.

Because works of nonfiction are always composed of literary tropes and metaphors, they have to be read critically for the ways in which their truth claims are potentially structured by ideologies and stereotypes. This essay reads passages from Richard Sennett’s sociological analysis Flesh and Stone, The Body and the City in Western Civilization and Joseph Brodsky’s memoir Watermark in order to demonstrate how these alleged works of nonfiction shore up some dishearteningly familiar literary stereotypes of male homosexuality and participate in a tradition, dating from the 19th century, of linking the city of Venice with homosexuality and death.
Benefit-Cost Analysis of Weather Information for Winter Maintenance: A Case Study

Surface transportation in the United States is continuously affected by adverse weather conditions, which contribute to thousands of highway fatalities and billions of dollars in economic loss every year. Winter weather has its own peculiar challenges, to which transportation agencies respond through winter maintenance operations. Recent trends toward proactive winter maintenance operations have placed a premium on the value of timely and accurate weather information that reflects current and forecast conditions in the roadway environment. However, few studies have sought to quantify this value and compare it to the costs of obtaining such customized weather information. The Utah Department of Transportation (DOT) implemented a weather operations program that assists the agency's operations, maintenance, and construction functions by providing detailed, often customized, area-specific weather forecasts. This program's genesis provides a useful case study to quantify the cost-effectiveness of weather infor...
Corrosion of Ferritic Steels in High Temperature Molten Salt Coolants for Nuclear Applications

Corrosion of ferritic steels, including oxide dispersion strengthened (ODS) variants, in high temperature molten fluoride salts may limit the life of advanced reactors, including some hybrid systems that are now under consideration. In some cases, the steel may be protected through galvanic coupling with other less noble materials with special neutronic properties such as beryllium. This paper reports the development of a model for predicting corrosion rates for various ferritic steels, with and without oxide dispersion strengthening, in FLiBe (Li2BeF4) and FLiNaK (Li-Na-K-F) coolants at temperatures up to 800 °C. Mixed potential theory is used to account for the protection of steel by beryllium, Tafel kinetics are used to predict rates of dissolution as a function of temperature and potential, and the thinning of the mass-transfer boundary layer with increasing Reynolds number is accounted for with dimensionless correlations. The model also accounts for the deceleration of corrosion as the coolants become saturated with dissolved chromium and iron. Electrochemical impedance spectroscopy has been used for the initial in situ study of an ODS ferritic steel in high-temperature molten fluoride salt environments, with the complex impedance spectra obtained at its open circuit corrosion potential (OCP) interpreted in terms of the basic components of the equivalent circuit, which include the electrolyte conductivity, the interfacial charge transfer resistance, and the interfacial capacitance. Such in situ measurement techniques may provide valuable insight into the degradation of materials under realistic conditions.
Patient perception of chronic illness care in a large inflammatory bowel disease cohort.

BACKGROUND Improvements in care for inflammatory bowel diseases could use the Chronic Care Model, an evidence-based approach that has improved patient outcomes and reduced costs in other illnesses. Specific aims include (1) to explore patient perception of chronic illness care in a large inflammatory bowel disease cohort and (2) to determine whether demographic factors, medication adherence, quality of life, disease type, and activity were associated with perception of chronic illness care. METHODS We randomly selected 1000 participants from the Crohn's and Colitis Foundation of America Partners Internet cohort to receive the validated Patient Assessment of Chronic Illness Care (PACIC) instrument, which measures patient experience with specific aspects of care congruent with the Chronic Care Model on a scale of 1 to 5, with 5 being highest perception of care. We used descriptive and bivariate statistics to assess relationships. RESULTS Nine hundred and forty-five participants completed the PACIC (576 Crohn's disease, 339 ulcerative colitis, and 30 indeterminate or other; 74% female, mean age 45 [SD = 15.1], mean PACIC 2.4 [SD = 0.93]). Recent gastroenterologist visit, hospitalization, surgery, and current pouch/ostomy were all associated with significantly higher PACIC (P < 0.05). PACIC correlated positively with quality of life (Pearson's correlation = 0.12, P = 0.003) but not medication adherence or disease activity. CONCLUSIONS Reports of chronic illness care in this inflammatory bowel disease cohort are in the same range as other illnesses. PACIC is positively associated with quality of life, so efforts to align care with the Chronic Care Model may benefit this population. Subjects who had more subspecialty interactions reported an increased perception of care, indicating the important role of direct patient contact.
Management of Child and Adolescent Stuttering with Olanzapine: Three Case Reports

Vast arrays of medications have been used, with limited success, to manage stuttering. Haloperidol and risperidone are the only two medications that have shown efficacy via double-blind studies in controlling stuttering symptoms. We present the first case reports of olanzapine in the management of stuttering. Three case histories are presented: a 10-year-old boy, a 16-year-old male adolescent with developmental stuttering, and a 9-year-old boy with medication-induced stuttering whose symptoms are successfully controlled with olanzapine. These case studies suggest that olanzapine may be a pharmacologic option in the management of stuttering.
Analysis of experimental measurements of PWR fresh and spent fuel assemblies using Self-Interrogation Neutron Resonance Densitometry

Abstract Self-Interrogation Neutron Resonance Densitometry (SINRD) is a new NDA technique that was developed at Los Alamos National Laboratory (LANL) to improve existing nuclear safeguards measurements for LWR fuel assemblies. The SINRD detector consists of four fission chambers (FCs) wrapped with different absorber filters to isolate different parts of the neutron energy spectrum and one ion chamber (IC) to measure the gross gamma rate. As a result, two different techniques can be utilized using the same SINRD detector unit and hardware. These techniques are the Passive Neutron Multiplication Counter (PNMC) method and the SINRD method. The focus of the work described in this paper is the analysis of experimental measurements of fresh and spent PWR fuel assemblies that were performed at LANL and the Korea Atomic Energy Research Institute (KAERI), respectively, using the SINRD detector. The purpose of these experiments was to assess the following capabilities of the SINRD detector: 1) reproducibility of measurements to quantify systematic errors, 2) sensitivity to water gap between detector and fuel assembly, 3) sensitivity and penetrability to the removal of fuel rods from the assembly, and 4) use of PNMC/SINRD ratios to quantify neutron multiplication and/or fissile content. The results from these simulations and measurements provide valuable experimental data that directly supports safeguards research and development (R&D) efforts on the viability of passive neutron NDA techniques and detector designs for partial defect verification of spent fuel assemblies.
The hydrolysis of 3-(2-furylacryloy)-glycyl-l-leucine amide by thermolysin☆

Abstract The kinetics of the hydrolysis of 3-(2-furylacryloyl)-glycycl- l -leucine amide by thermolysin has been reinvestigated. It was found that the K m for the enzyme substrate interaction is 2.5 × 10 −3 m at pH 7.2. This K m is an order of magnitude less than what has been previously assumed to be the K m for the enzyme-substrate interaction. The normally recommended assay has 1–3 × 10 −3 m substrate and is based on the assumption that the substrate concentration is much less than the K m . Our data indicate that this assumption appears to be invalid. The hydrolysis of 3-(2-furylacryloyl)-glycyl- l -leucine amide results in a maximum decrease in absorbance at 322 nm. The change in absorbance is nearly 10-fold greater at 322 nm than the change in absorbance at 345 nm where the hydrolysis has been customarily followed. By following the hydrolysis of the substrate at 10 −4 m at 322 nm it is possible to work under conditions where the substrate concentration is much less than the K m .
Comparative studies of keratins isolated from psoriasis and atopic dermatitis

Keratin proteins were extracted from scales of normal skin, clinically active psoriatic lesions, and atopic dermatitis. Filaments prepared by in vitro assembly upon dialysis of the proteins against a low ionic strength buffer were comparatively characterized by electron microscopy, SDS gel electrophoresis, and amino acid analysis. Filaments formed using keratin obtained from the skin of normal individuals were thin and wavy, whereas those formed using keratin isolated from the scales of psoriatic patients were straight and showed a tendency to assemble side by side. Filaments of atopic dermatitis were indistinguishable from those of normal individuals. Filaments of both normal and atopic dermatitis contained the protein band of 67,000 daltons, which was absent in filaments of psoriasis. In contrast, 2 protein bands of 54,000 and 57,000 daltons were only detectable in psoriasis. Amino acid analysis of these filaments further demonstrated that filaments of psoriasis differ from those of normal individuals in that they have a glycine content that is 60% of normal.
Objective Evidence of Myocardial Ischemia in Patients with Posttraumatic Stress Disorder

Background Patients with posttraumatic stress disorder (PTSD) are at increased risk for cardiovascular disease (CVD), but few studies have included objective measures of CVD and how PTSD causes CVD remains unknown. We sought to determine the association between PTSD and objectively assessed CVD and examine potential underlying mechanisms. Methods Outpatients from two Veterans Affairs Medical Centers were enrolled from 2008 to 2010. Posttraumatic stress disorder was identified using the Clinician Administered PTSD Scale, and standardized exercise treadmill tests were performed to detect myocardial ischemia. Results Of the 663 participants with complete data, ischemia was present in 17% of patients with PTSD versus 10% of patients without PTSD ( p = .006). The association between PTSD and ischemia remained significant after adjusting for potential confounders (age, sex, prior CVD) and mediators (traditional cardiac risk factors, C-reactive protein, obesity, alcohol use, sleep quality, social support, and depression), adjusted odds ratio (OR) 2.42, 95% confidence interval (CI) 1.39 to 4.22, p = .002. Findings remained significant when those with prior CVD were excluded (fully adjusted OR 2.24, 95% CI 1.20–4.18, p = .01) and when continuous PTSD symptom score was used as the predictor (fully adjusted OR per 10-point change in Clinician Administered PTSD Scale score 1.12, 95% CI 1.03–1.22, p = .01). Conclusions Posttraumatic stress disorder was associated with ischemic changes on exercise treadmill tests independent of traditional cardiac risk factors, C-reactive protein, and several health behaviors and psychosocial risk factors, suggesting additional mechanisms linking PTSD and ischemia should be explored. The association of PTSD and ischemia among patients without known CVD highlights an opportunity for early interventions to prevent progression of cardiovascular disease.
Laparoscopically assisted vaginal hysterectomy in a university hospital: Report of 82 cases and comparison with abdominal and vaginal hysterectomy

Objective: The objective of this study was to critically review the indications, outcomes, complications, and costs of laparoscopically assisted vaginal hysterectomy in comparison with abdominal and vaginal hysterectomy. Study Design: The operating room log was reviewed to determine the number and route of hysterectomies performed over a 1-year period. The charts of 50 consecutive laparoscopically assisted vaginal hysterectomies and 50 vaginal hysterectomies were reviewed. Charts from 50 selected abdominal hysterectomies were also reviewed. Information on patient characteristics, indications, complications, uterine weights, hospital stay, and patient costs were obtained and analyzed. Results: Of 509 hysterectomies, 82 were performed as laparoscopically assisted vaginal hysterectomies and 73 as vaginal hysterectomies. The patient characteristics and indications of the laparoscopically assisted group more closely matched those of the abdominal hysterectomy group. The complication rate in the laparoscopically assisted group was intermediate between the other two groups, but the hospital stay was significantly less. Patient cost for laparoscopically assisted vaginal hysterectomy was significantly greater than either abdominal or vaginal hysterectomy, in spite of the shortened hospital stay. Conclusions: Laparoscopically assisted vaginal hysterectomy offers a technique to convert some abdominal hysterectomies into vaginal hysterectomies. It appears particularly useful when an adnexal indication for surgery exists. Uterine leiomyoma does not appear to be an indication for laparoscopically assisted vaginal hysterectomy. The costs are significant because of increased operating time and costs of disposable equipment.