cssi/SciSciGPT-SciSciNet huggingface dataset:
Autoimmune hemolytic anemia with hemoglobinemia and hemoglobinuria in the absence of a demonstrable hemolysin or complement-binding antibody.

Summary. The present report describes the occurrence of hemoglobinemia and hemoglobinuria in a patient with warm antibody hemolytic anemia in whom extensive studies failed to demonstrate the presence of a hemolysin or complementfixing antibody. Studies of the patient's red cells revealed only gamma globulin coating. Studies of the patient's serum revealed the presence of a γG globulin antibody capable of coating normal cells with gamma globulin but not with complement. No hemolysin could be demonstrated even with the use of special techniques known to enhance detection of hemolytic antibodies. Based on these negative findings and on previous experimental and clinical observations concerning the iso-antibody, anti D, the possibility is raised that the hemoglobinuria observed in this patient resulted from extravascular red cell destruction of such magnitude that the capacity of the reticuloendothelial system to metabolize the products of red cell breakdown was exceeded.
Cerebrospinal fluid and plasma C-reactive protein and aggression in personality-disordered subjects: a pilot study

C-reactive protein (CRP), in the plasma, serves as a marker of systemic inflammation and has been shown to correlate with history of actual aggressive behavior, and as a personality trait of aggressive tendency, in human subjects. This pilot study was conducted to determine if plasma CRP levels are correlated with cerebrospinal fluid levels (CSF CRP) and if CSF CRP also correlates with aggression. If so, this would suggest a role for central inflammatory processes in human aggression. Both plasma and basal lumbar CSF samples were obtained from 17 subjects with DSM-5 personality disorder and assayed for CRP. Plasma and CSF CRP levels were correlated (r = 0.65, p = 0.005) and each correlated with aggression (Plasma: r = 0.53, p = 0.029; CSF: r = 0.84, p < 0.001). When considered simultaneously, CSF CRP, but not plasma CRP, uniquely correlated with aggression. No relationship was seen with other measures of psychopathology. These data suggest a positive relationship between central nervous system CRP and aggression in humans.
Along for the Ride Best Friends’ Resources and Adolescents’ College Completion

Research on social capital in education rarely considers how the resources students can access through their friendships affect educational outcomes later in life. Using the National Longitudinal Study of Adolescent Health, we explore how having resource-rich best friends impacts adolescents’ college completion. We compare the influence of friends’ material and cultural resources and their effects relative to adolescents’ family resources. We find that having a best friend with a college-educated mother significantly increases the likelihood of college completion, though having a best friend whose parents are high income does not. This positive effect of best friends’ cultural resources is not explained fully by school achievement or by the expectations of respondents, best friends, or parents. We conclude that adolescent friendships are an underrecognized source of social capital.
Effect of Leaf Age and Nodal Position on Receptivity of Rice Leaves to Infection by Pyricularia grisea

The effect of leaf age and nodal position on leaf receptivity to rice blast, caused by Pyricularia grisea, was studied by inoculating potted Rosemont plants with blast pathogen race IC-17, isolate 92T107, at different growth stages. Regression equations were used to describe the effect of leaf age (degree days > 10 C) and nodal position on lesion density, the relative frequency of lesion appearance, and the lesion area distribution. The number of sporulating lesions per cm 2 of inoculated leaf area was highest for leaves inoculated early in their development and progressively lower for leaves inoculated later in their development. The average lesion density for less than 1-day-old leaves at nodal position 6 was about four times the density for 10-day-old leaves of the same nodal position. Lesion density was similar for leaves of less than 1-day-old from the 4th to the 7th nodal position, but dropped sharply from the 7th to the 11th nodal position. The flag leaf was the least susceptible of all nodal positions. The average lesion density for young leaves of about 1-day-old at nodal position 6 was about 27 times the density for young flag leaves of the same age. The incubation period increased with leaf age, but was not obviously affected by leaf nodal position. Lesion area increased linearly with time, but was not affected by leaf age and nodal position. The results are of use for epidemiological investigations which rely on detailed quantitative leaf susceptibility data for accurate blast forecasts.
Application of pattern recognition techniques to fault tolerant software systems

Inference techniques are applied to computing systems to improve the allocation of resources for fault tolerant performance. Using a general model for such systems, the influence of estimation errors for system parameters on the resulting system fault performance is examined. These results are then applied to the problem of error mode testing-finding the underlying error structure of the system. Simulation is used to illustrate the properties discussed.
VSM Simulation of Perpendicular Recording

We report simulations of the writing process of isolated transitions with a magnetometer for perpendicular recording. The fields of three different head types, a pole head, a shielded pole head and a ring head were used to study the writing of transitions on two perpendicular media, one with a very square loop and the other one with a shallow loop. It is found that the shielded head records the narrowest transitions, followed by the ring and then by the pole head
A Simulation Framework for Subjective Listening Evaluation of Synthesized Automotive Sounds

This paper describes a simulation experiment to study the subjective listening evaluation of synthesized automotive sounds. Three types of digitized automotive sounds are used in the experiment: stationary, nonstationary, and impulsive. These are modeled and synthesized using a newly developed multipulse excitation technique, the characteristics of which can be controlled through careful selection of four key parameters. A blind subjective assessment scheme is devised and nine evaluators are asked to judge the qualities of the sounds syn thesized under varying parametric settings. An analysis of variance (ANOVA) performed on the experimental data reveals a number of useful relationships among the (perceived) qual ity, compression efficiency, and parametric set tings. The paper includes a detailed description of the simulation experiment and the results.
Internal structure of uppermost oceanic crust along the Western Blanco Transform Scarp: Implications for subaxial accretion and deformation at the Juan de Fuca Ridge

[1] The uppermost 2 km of oceanic crust created near the southern end of the Juan de Fuca Ridge (∼60 mm/yr, full spreading rate) is exposed in a “tectonic window” created along the north wall of the Blanco Transform Fault. A total of 27 submersible dives transect this escarpment over a distance of >30 km, corresponding to ∼1 m.y. of spreading history. In this exposure, weakly deformed basaltic lavas grade downward into much more intensely fractured lavas cut by basaltic dikes. Lava flow surfaces dip persistently to the northwest (toward the spreading center) and the dikes dip southeast (away from the spreading center). The underlying sheeted dike complex is composed of subparallel dikes that dip moderately to the southeast. Discrete faults and more distributed cataclastic deformation zones separate the panels of sheeted dikes from one another. Disruption of the lava and dike units are interpreted as a result of dramatic, subaxial, vertical mass transport that created the “accommodation space” for the accumulation of a thickness of 1000–1500 m of basaltic lava. The observed patterns of tilting of lavas and dikes imply subsidence beneath the region of active volcanism (∼3 km wide) that is most rapid near the axis and diminishes quickly off-axis. Deformation that accommodates this subsidence has generated extensive fracture porosity in the subaxial region that could strongly influence upper crustal hydrothermal pathways, alteration history, seismic properties, and the distribution of subsurface biological communities.
Verifying GPU kernels by test amplification

We present a novel technique for verifying properties of data parallel GPU programs via test amplification. The key insight behind our work is that we can use the technique of static information flow to amplify the result of a single test execution over the set of all inputs and interleavings that affect the property being verified. We empirically demonstrate the effectiveness of test amplification for verifying race-freedom and determinism over a large number of standard GPU kernels, by showing that the result of verifying a single dynamic execution can be amplified over the massive space of possible data inputs and thread interleavings.
An Eight-Year Analysis of Surgical Morbidity and Mortality: Data and Solutions

In this article, a reproducible process for presenting, analyzing, and reducing early and late surgical morbidity and mortality (M&M) is detailed. All M&M cases presented from 1998 through 2005 at Monmouth Medical Center were categorized. Residents and nurses were empowered to report the complications. The five major categories were overwhelming disease on admission, delays in treatment, diagnostic or judgment complications, treatment complications, and technical complications. From the 53,541 operations performed over 8 years, 714 patients were presented, which included 147 deaths and 1,132 category entries. The most common problems were technical complications in 474 (66.4%) patients. The data have generated actionable solutions, many with low barriers to adoption, resulting in safer, less expensive surgical management. Surgical outcome benchmarks have been established and are used for credentialing surgeons. The "Hostile Abdomen Index" has been developed to assess the safest choice for abdominal operative access, pre- and intraoperatively. We explained the real-time process that generated solutions for the entire department as well as changes relevant to residency training and individual operative techniques.
Exposing the Processes of Empire in the International Protection of Intellectual Property

The foundational international documents of international intellectual property protection – the Berne Convention for the Protection of Literary and Artistic Works and the Paris Convention for the Protection of Industrial Property – were created within the economic, sociologic and political milieu of Nineteenth Century Neo-Imperialism. Neo-imperialism is only one narrative that helps explain the dissonant policy choices reflected in these documents concerning the scope of protection afforded patents and copyrights. It is a powerful one, nonetheless, because it places the empowerment of various actors in the debates over conflicting choices between protection and free access against the more complex and yet more realistic milieu in which protectionist choices were made. Such analysis demonstrates that the standards memorialized in the Berne and Paris Conventions did not represent any inevitable protectionist choice. To the contrary, conflicting concerns among domestic actors regarding the impact of 'free trade,' access to knowledge (often termed 'science' in the debates), and protection of workers over private multinational actors were not wholly resolved in the march to uniformity that the Berne and Paris Conventions represented. Yet the narrative of imperialism, with its four major dynamic processes - the hunt for raw materials, the search for foreign markets for the end products of Western technology, a 'civilizing' message of progress, and the unilateral nature of its standard making - had an undoubted impact, providing not only the philosophical analogues for emerging international standards, but also the institutional and regulatory webs necessary to place economic and political power in the hands of the actors and institutional governance structures that helped solidify generally protectionist policy choices. While the processes of Empire do not fully explain the choices made, they shed new light on the normative values represented by the Berne and Paris Conventions and warn of the role economics and political expediency can play in the face of dissonant policy choices in today’s debates.
Standardized education for nursing

The need for establishing standardized education for nursing is discussed. New health needs, patient demands, and technological advances are causing changes in the health-care system that affect the future of nursing. To meet these changes, the American Nurses' Association (ANA) has proposed that the baccalaureate degree be the entry-level degree for future professional nurses. Currently, many nurses' educational competencies are not matched by the suitable job category. This leads to frustration and problems with underutilization and misutilization of nurses that affects the delivery of health-care services. The ANA has proposed a clearer delineation of nurses into two equally valid categories, each of which will include nurses with a specific educational preparation, to alleviate these problems. The nurse educated at the associate degree (diploma) level will be a member of a nursing team and practice within specific limits. The nurse prepared at the baccalaureate level will have a more comprehensive education to help evaluate and design a patient's treatment plan, perform research, coordinate the work of other health personnel, and attain advanced degrees in specialized clinical areas. To answer many of the objections to its proposal, the ANA has emphasized the need for implementing continuing education programs for all nurses and baccalaureate-degree programs for diploma and associate-degree nurses who want to earn that degree. ANA advocates that such programs give credit for the experience and the on-the-job training that registered nurses have had. Establishing standardized education for nursing is proposed as the best means for the profession to be prepared to meet the demands of the future and for the delivery of better health care.
Effect of Behavioral Interventions on Inappropriate Antibiotic Prescribing Among Primary Care Practices: A Randomized Clinical Trial

Importance Interventions based on behavioral science might reduce inappropriate antibiotic prescribing. Objective To assess effects of behavioral interventions and rates of inappropriate (not guideline-concordant) antibiotic prescribing during ambulatory visits for acute respiratory tract infections. Design, Setting, and Participants Cluster randomized clinical trial conducted among 47 primary care practices in Boston and Los Angeles. Participants were 248 enrolled clinicians randomized to receive 0, 1, 2, or 3 interventions for 18 months. All clinicians received education on antibiotic prescribing guidelines on enrollment. Interventions began between November 1, 2011, and October 1, 2012. Follow-up for the latest-starting sites ended on April 1, 2014. Adult patients with comorbidities and concomitant infections were excluded. Interventions Three behavioral interventions, implemented alone or in combination:suggested alternativespresented electronic order sets suggesting nonantibiotic treatments;accountable justificationprompted clinicians to enter free-text justifications for prescribing antibiotics into patients’ electronic health records;peer comparisonsent emails to clinicians that compared their antibiotic prescribing rates with those of “top performers” (those with the lowest inappropriate prescribing rates). Main Outcomes and Measures Antibiotic prescribing rates for visits with antibiotic-inappropriate diagnoses (nonspecific upper respiratory tract infections, acute bronchitis, and influenza) from 18 months preintervention to 18 months afterward, adjusting each intervention’s effects for co-occurring interventions and preintervention trends, with random effects for practices and clinicians. Results There were 14 753 visits (mean patient age, 47 years; 69% women) for antibiotic-inappropriate acute respiratory tract infections during the baseline period and 16 959 visits (mean patient age, 48 years; 67% women) during the intervention period. Mean antibiotic prescribing rates decreased from 24.1% at intervention start to 13.1% at intervention month 18 (absolute difference, −11.0%) for control practices; from 22.1% to 6.1% (absolute difference, −16.0%) for suggested alternatives (difference in differences, −5.0% [95% CI, −7.8% to 0.1%];P = .66 for differences in trajectories); from 23.2% to 5.2% (absolute difference, −18.1%) for accountable justification (difference in differences, −7.0% [95% CI, −9.1% to −2.9%];P Conclusions and Relevance Among primary care practices, the use of accountable justification and peer comparison as behavioral interventions resulted in lower rates of inappropriate antibiotic prescribing for acute respiratory tract infections. Trial Registration clinicaltrials.gov Identifier:NCT01454947
Breaking bread with the dead.

The establishment of two international ad hoc tribunals for Rwanda and the former Yugoslavia, and the creation of an International Criminal Court within the next five years, has increased the need for archaeologists who can assist in the exhumation of individual and mass graves associated with war crimes and genocide throughout the world. This work examines the efforts of teams of archaeologists and forensic scientists which have investigated forced disappearances, political killings, and war crimes in Argentina, Guatemala, Iraqi Kurdistan, and the former Yugoslavia since 1984. As more archaeologists enter this growing field, it is becoming apparent that their training at the university and post-graduate level needs to be supplemented with courses that will better prepare them for international forensic work. Not only do they need to be trained in forensic methods and procedures, they also need to be knowledgeable of legal and evidenciary procedures and the political and cultural dynamics of the countries where they will be working.
Development of New Frame Finite Elements for Aircraft Crash Analysis

The objective of current development is to give additional capabilities to the currently used MASS-SPRING/LINEAR BEAM based analysis methodology (KRASH). By adding nonlinear frame elements specialized for crash analysis, the effort of creating new models is expected to be reduced. Presently, a complex frame structure would be modeled by a series of discrete nonlinear springs without modeling the structural details, whose properties are specified mainly using experimental data. The element under development will allow us to model the frame structure in detail without increase of computational cost, and will reduce the modeling effort.
Hospital Charity Care — Effects of New Community-Benefit Requirements

U.S. nonprofit hospitals must now have written policies regarding charity care, charge reasonable amounts for it, refrain from extraordinary bill-collection practices, and assess community health needs every 3 years. The effects on charity care are likely to be mixed.
System level dynamic modeling framework being developed at Clemson University's Wind Turbine Drivetrain Testing Facility

This paper describes the system level, dynamic modeling and simulation strategy being developed at the Wind Turbine Drivetrain Testing Facility (WTDTF) at Clemson University’s Restoration Institute in North Charleston, SC, USA. An extensible framework that allows various workflows has been constructed and used to conduct preliminary analysis of one of the facility’s test benches. The framework dictates that component and subsystem models be developed according to a list of identified needs and modeled in software best suited for the particular task. Models are then integrated according to the desired execution target. This approach allows for compartmentalized model development which is well suited for collaborative work. The framework has been applied to one of the test benches and has allowed researches to begin characterizing its behavior in the time and frequency domain.© 2013 ASME
Perspectives in Lung Cancer--Third Asian-pacific Conference. 11-12 September 2009, Bangkok, Thailand.

Abstract The Third Asian-Pacific Conference on Perspectives in Lung Cancer held in Bangkok included topics covering new therapeutic developments in the field of lung cancer. This conference report highlights selected presentations on the management and maintenance of lung cancer from an Asian perspective.
Canes modernos, posmodernos y trasatlánticos: Hibridismo textual y acusación social de Cervantes a Luis Rafael Sánchez

This essay touches on certain parallelisms between Puerto Rican author Luis Rafael Sanchez’s most recent novel (Indiscreciones de un perro gringo, Alfaguara 2007) and Cervantes’ ‘El coloquio de los perros’ (Novelas ejemplares, 1615). By means of canine narrators, both works expose, criticize and denounce social maladies and general injustices. Despite the geographical and temporal distance that separates them, these dogs condemn the arrogance and nonsense imposed by imperialist powers over their colonies.
Intervention of Dexamethasone on Expression Levels of Intercellular Adhesion Molecule-1 and Lymphocyte Function-Associated Antigen-1 mRNA of Peripheral Blood Mononuclear Cells in Children with Febrile Seizures

Objective To analyze the expressions of peripheral blood mononuclear cells(PBMC) intercellular adhesion molecule-1(ICAM-1) and lymphocyte function-associated antigen-1(LFA-1) immunoreaction in patients following febrile seizures(FS),in order to find out the neuroimmunomodulation mechanisms in the pathogenesis of FS. Methods Sixteen cases of FS were divided into 2 groups randomly:FS control group and dexamethasone(DXM)-treated group.Sixteen cases of healthy children whose age and sex were matched to the patients were selected as healthy control group.PBMC were dissected,purified and cultured in conventional method.The expression levels of PBMC ICAM-1 and LFA-1 were detected by flow cytometry.Then,ICAM-1 and LFA-1 concentration in these supernatants were detected with enzyme-linked immunosorbent assay. Results ICAM-1 and LFA-1 expressions [(19.78±8.93)% and(43.05±15.85)%] in PBMC cultured in vitro in FS control group were significantly higher than those in normal control group [(13.88±6.73)% and(30.43±16.25)%](Pa0.05).Compared with FS control group,ICAM-1,LFA-1 expressions [(17.14±7.98)% and(33.93±19.76)]in DXM group represented downtrend after the treatment with DXM in PBMC,but there was no statistical difference between the 2 groups(Pa0.05). The secreting values of ICAM-1 and LFA-1 expressions in PBMC cultured in vitro in FS control group were(6.73±3.88)% and(4.84±2.95)%,which were significantly higher than the secreting levels in normal control group [(4.24±2.42)% and(2.76±1.36)%]. On the other hand,ICAM-1 and LFA-1 secretion levels[(4.34±1.82)% and(3.06±2.81)%] were significantly lower than those in FS control group,and there was statistical difference between the 2 groups(Pa0.05). Conclusion The down-regulation of LFA-1 and ICAM-1 levels of FS might be associated with stimulation of inflammatory media DXM.
Maintenance of Erection of Penile Glans, but not Penile Body, after Transection of Rat Cavernous Nerves

AbstractTwo experiments tested the widely held assumption that the cavernous nerves (CN) are essential not only to erection of the penile body, via the corpora cavernosa, but also to erection of the glans penis, via the corpus spongiosum. In Experiment 1, the copulatory behavior and reflexive erections of male rats were studied before and after the CN were transected bilaterally (n = 8), unilaterally (n = 6), or sham-operated (n = 6). In postoperative tests, bilaterally operated males were severely impaired in their attempts to effect intromission, and they had the expected deficits in reflexive erections of the penile body, but their capacity for erection of the glans penis was only minimally impaired. Sham-operated males were unaffected by surgery, and unilaterally transected males had intermediate values. Experiment 2 tested the hypothesis that activity of the bulbospongiosus muscles was responsible for the residual erectile capacity of the glans after CN transection in Experiment 1. Males had bilatera...
Grain sorghum dust increases macromolecular efflux from the in situ nasal mucosa

The purpose of this study was to determine whether an aqueous extract of grain sorghum dust increases macromolecular efflux from the nasal mucosa in vivo and, if so, whether this response is mediated, in part, by substance P. Suffusion of grain sorghum dust extract on the in situ nasal mucosa of anesthetized hamsters elicits a significant increase in clearance of fluorescein isothiocyanate-labeled dextran (FITC-dextran; mol mass, 70 kDa; P < 0.05). This response is significantly attenuated by CP-96345 and RP-67580, two selective, but structurally distinct, nonpeptide neurokinin 1 (substance P)-receptor antagonists, but not by CP-96344, the 2R,3R enantiomer of CP-96345 (P < 0.05). CP-96345 has no significant effects on adenosine-induced increase in clearance of FITC-dextran from the in situ nasal mucosa. CP-96345 and RP-67580, but not CP-96344, significantly attenuate substance P-induced increases in clearance of FITC-dextran from the in situ nasal mucosa (P < 0.05). Collectively, these data suggest that grain sorghum dust elicits neurogenic plasma exudation from the in situ nasal mucosa.
29 Predicting short-term response to plantar massage in those with chronic ankle instability

Background Plantar massage improves balance impairments associated with chronic ankle instability (CAI). However, there is no data to determine which patients with CAI would respond favourably to a plantar massage intervention. Objective To develop a preliminary clinical prediction rule that identifies which patients with CAI would have a favourable postural control response after a 2-week plantar massage intervention. Design Prospective cohort study. Setting Research laboratory. Participants Nineteen participants with self-reported CAI (age = 22.3 ± 2.8 years; height = 1.7 ± 0.8 m; body mass = 75.5 ± 14.2 kg) participated. CAI was defined as at least two episodes of “giving way” within the past 3 months (mean = 5.4 ± 4.8); scoring ≤90% on the Foot and Ankle Ability Measure (FAAM) (mean = 76.8 ± 12.9%, and scoring ≤80% on the FAAM-Sport (mean = 62.7 ± 13.6%). Interventions Patients received 6, 5-minute plantar massage treatments over a 2-week period. Main outcome measurements Single limb balance (SLBT) was assessed via 3, 20-second trials on a firm surface with eyes closed while errors were tracked. SLBT was recorded before, after the first treatment, and after the final treatment. A favourable response was defined as a change in the SLBT score that exceeded the minimum detectable change after the 2-week intervention. Potential predictor variables were entered into a stepwise logistic regression model to determine the most accurate set of variables for predicting treatment success. Results 10 of the 19 participants had a favourable response (52.6%). Baseline FAAM-Sport scores >70.31% and an SLBT change of >1.67 errors after the first treatment predicted a favourable response (combined r2 = 0.545). Both factors resulted in a 100% favourable response rate while one and no factors resulted in an 86% and 0% favourable response rate respectively. Conclusion Preliminary results suggest that a FAAM-Sport baseline score and an immediate change in SLBT can accurately determine which CAI patients will have a favourable postural control outcome following a 2-week plantar massage intervention.
Comparison of Lumbopelvic Coordination between Trunk Flexion and Extension

Lumbopelvic coordination describes the relative contributions of lumbar and pelvis to the total trunk flexion/extension motion, which has been identified as a major influential factor to spinal loading. The current study investigated the differences in lumbopelvic coordination between trunk flexion and extension. Thirteen subjects performed pace-controlled trunk flexion/extension motions in the sagittal plane while lumbopelvic continuous relative phase and phase variability were quantified. The results demonstrated that compared with trunk extension, lumbopelvic continuous relative phase and phase variability were 28% and 117% greater in trunk flexion motion, respectively, which indicated a more anti-phase and unstable coordination pattern. Quantifying these coordination patterns helps identifying abnormal patterns and serves as normative benchmarks during low back pain rehabilitation.
Do magnetic fabrics of marine deposits preserve orbital forcing? A test case in the Southern Ocean, Antarctic Peninsula

The anisotropy of magnetic susceptibility (AMS), or magnetic fabric, of marine sediments is related to depositional current strength; higher AMS values indicate stronger currents. We have collected a 3.1 m.y. record of AMS data from the abyssal silts of Drift 4 (Ocean Drilling Program Site 1101) on the Pacific margin of the Antarctic Peninsula. Spectral analyses of these data show strong, uniform, 100 k.y. and 400 k.y. power in-phase with minima in Earth’s eccentricity throughout the long record. However, significant variability related to the 40 k.y. period of obliquity is absent. The unchanging strong 100 k.y. power and the apparent absence of 40 k.y. variability in the AMS record are in contrast to the behavior of most other paleoclimatic proxies for late Pliocene and Pleistocene time.
O Brother Where Art Thou? Inferno 26 secondo i fratelli Coen

This essay challenges the traditional critical interpretation of the Coen Brothers’ 2001 film “O Brother Where Art Thou” by proposing that the film is not simply a retelling of the Odyssey but rather that it looks not to the Homeric narrative but rather to Dante’s reinvention of the Greek hero Odysseus / Ulysses for its inspiration. In support of this argument the essay highlights a number of narrative cues that point us to Inferno 26, where Ulysses is punished as a fraudulent counselor. The fact that the film’s protagonist, Ulysses Everett McGill was convicted of impersonating a lawyer and lied to his “brothers” Delmar and Pete to induce them to escape with him, are but two such indicators examined in this study. But the essay also looks at the role that the soundtrack plays in alerting the reader to a highly Dantesque hermeneutic strategy, as well as the film’s Dantesque awareness of the role of ingegno in creating fiction, or lies that look like truth.
Microscopy Study of Morphology of Electrospun Fiber-MOF Composites with Secondary Growth

Microscopy studies were performed over a series of metal-organic-framework (MOF) imbedded electrospun fibers. Analysis of as-spun fibers revealed five different MOF particle-fiber imbedded morphologies including complete particle encasement, over-filled, surface-bound, welded, and agglomerated. To mitigate issues with fiber breakup during electrospinning (ES) due to MOF particle incorporation, secondary growth method was used. Secondary growth was performed on both Matrimid and polysulfone fibers impregnated with a MOF, ZIF-8, in either water or methanol solvents. Results show that when water was used, crystal formation was limited to formation on the top layer of the fiber mat due to hydrophobicity. When methanol was used in place of water, MOF crystal growth occurred in a patchwise manner, where crystals grow across fibers and span the entire fiber mat. From this work, it was determined that successful secondary growth of MOF imbedded electrospun fibers can be accomplished when particles are either highly exposed along the fiber surface for adequate exposure to solvent, or the solvent used promotes reactant penetration into the polymer to allow access to the seeded MOF crystals.
Acoustic metamaterials: Living bandgaps.

Sound waves drive the organization of particle scatterers into stable structures, exhibiting phononic band gaps that heal from disturbances and adapt to changes in the drive.
Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.

Akt plays a major role in tumorigenesis and the development of specific Akt inhibitors as effective cancer therapeutics has been challenging. Here, we report the identification of a highly specific allosteric inhibitor of Akt through a FRET-based high-throughput screening, and characterization of its inhibitory mechanism. Out of 373,868 compounds screened, 4-phenylquinolin-2(1H)-one specifically decreased Akt phosphorylation at both T308 and S473, and inhibited Akt kinase activity (IC50 = 6 µM) and downstream signaling. 4-Phenylquinolin-2(1H)-one did not alter the activity of upstream kinases including PI3K, PDK1, and mTORC2 as well as closely related kinases that affect cell proliferation and survival such as SGK1, PKA, PKC, or ERK1/2. This compound inhibited the proliferation of cancer cells but displayed less toxicity compared to inhibitors of PI3K or mTOR. Kinase profiling efforts revealed that 4-phenylquinolin-2(1H)-one does not bind to the kinase active site of over 380 human kinases including Akt. However, 4-phenylquinolin-2(1H)-one interacted with the PH domain of Akt, apparently inducing a conformation that hinders S473 and T308 phosphorylation by mTORC2 and PDK1. In conclusion, we demonstrate that 4-phenylquinolin-2(1H)-one is an exquisitely selective Akt inhibitor with a distinctive molecular mechanism, and a promising lead compound for further optimization toward the development of novel cancer therapeutics.
The racial matters of citizenship

On November 7, 2016, Donald J. Trump was elected as the 45th President of the United States on a platform that both promoted and celebrated his history of sexual assault and aired incredulously bla...
Modification of a Three-Compartment Muscle Fatigue Model to Predict Peak Torque Decline During Intermittent Tasks

This study aimed to test whether adding a rest recovery parameter, r, to the analytical three-compartment controller (3CC) fatigue model (Xia and Frey Law, 2008) will improve fatigue estimates during intermittent contractions. The 3CC muscle fatigue model uses differential equations to predict the flow of muscle between three muscle states: Resting (MR), Active (MA), and Fatigued (MF). This model uses a feedback controller to match the active state to target loads and two joint-specific parameters: F, fatigue rate controlling flow from active to fatigued compartments) and R, the recovery rate controlling flow from the fatigued to the resting compartments. This model does well to predict intensity-endurance time curves for sustained isometric tasks. However, previous studies find when rest intervals are present that the model over predicts fatigue. Intermittent rest periods would allow for the occurrence of subsequent reactive vasodilation and post-contraction hyperemia. We hypothesize a modified 3CC-r fatigue model will improve predictions of force decay during intermittent contractions with the addition of a rest recovery parameter, r, to augment recovery during rest intervals, representing muscle re-perfusion. A meta-analysis compiling intermittent fatigue data from 63 publications reporting decline in peak torque (% torque decline) were used for comparison. The original model over-predicted fatigue development from 19 to 29% torque decline; the addition of a rest multiplier significantly improved fatigue estimates to 6-10% torque decline. We conclude the addition of a rest multiplier to the three-compartment controller fatigue model provides a physiologically consistent modification for tasks involving rest intervals, resulting in improved estimates of muscle fatigue.
Abstract 649: Effect of Aging and Habitual Endurance Exercise on Vascular Endothelial NF-kappa;B Protein Expression and Dilation in Humans

Background: Aging is a major risk factor for clinical atherosclerotic diseases and is associated with impaired vascular endothelial function (e.g., decreased endothelium-dependent dilation, EDD) and reduced exercise capacity. Middle-aged and older adults who habitually perform aerobic exercise have a reduced risk of atherosclerotic diseases, preserved EDD and enhanced exercise capacity. The molecular mechanisms for these divergent effects are incompletely understood, but may involve different chronic states of low-grade vascular oxidative stress and inflammation. Nuclear factor-kappa B (NF-κB) is key redox-sensitive pro-inflammatory transcription factor linked to atherosclerosis. We hypothesized that these respective functional phenotypes of sedentary and physically active aging would be associated with increased and reduced endothelial NF-κB expression, respectively. Methods: EDD (brachial artery flow- mediated dilation), maximal exercise capacity (maximal oxygen uptake, VO 2 max) and venous endothelial cell protein expression of NF-κB p65 subunit (quantitative immunofluorescence of protein normalized to HUVEC control) were determined in young sedentary (YS: n=41, age 23 ± 1 yrs, 35M), older sedentary (OS: n=48, age 63 ± 1 yrs, 35M), and older trained (OT: n=22, age 63 ± 1 yrs, 22M) healthy adults. Results: There was decline in EDD (OS: 0.17 ± 0.01 mm, 4.35 ± 0.33 %; YS: 0.30 ± 0.01 mm, 7.52 ± 0.33 %, p 2 max (OS: 27.9 ± 0.7; YS: 44.7 ± 1.0, p 2 max (n=45; r =−0.365, p Conclusions: Vascular endothelial expression of NF-κB is increased in sedentary, but not in habitually exercising middle-aged and older healthy adults. These differences in endothelial NF-κB expression may be an important molecular mechanism contributing to differences in endothelial function, exercise capacity and risk of atherosclerotic diseases with sedentary and physically active aging in humans.
TOWARDS A CONTINGENCY FRAMEWORK FOR INTERVENTION IN THE CONTEXT OF A SYSTEMS-BASED APPROACH

In the practice of applying systems-based problem solving and learning approaches to a client system, the presence of mediating factors governing the outcome of the intervention is often not realized or may be assumed but not accounted for. Current theories of intervention are lacking a framework to enable a practitioner, experienced or novice, to understand and cope with various and oftentimes complex factors governing the success of the intervention. It is the purpose of this paper to examine the primary contingency factors involved in an intervention while employing a systems-based methodology such as SSM.
(215) Differential Expression of Axonal Transport Related Genes and Pathways in Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Survivors

Taxol is a common chemotherapy (CTX) drug that is associated with the development of neuropathy. Paclitaxel-induced peripheral neuropathy (PIPN) is the dose limiting toxicity of this CTX drug. Paclitaxel exerts its therapeutic effect by binding to β-tubulin, which interferes with microtubule dynamics and results in microtubule stabilization, mitotic arrest, and apoptosis of cancer cells. However, microtubules are critical for axonal function and for the transport of essential organelles to distal nerve endings. Disruption of axonal transport (AT) can lead to axonal degeneration and neuropathy. The purpose of this pilot study was to evaluate for differential expression (DE) and perturbations in AT related genes and pathways between breast cancer (BC) survivors who did (n=25) and did not (n=25) develop PIPN. Gene expression in peripheral blood was assayed using RNA-seq. BC survivors with PIPN were significantly older; more likely to be unemployed; reported lower alcohol use; had a higher BMI and a poorer functional status; and had a higher number of lower extremity sites with loss of light touch, cold, and pain sensations, and higher vibration thresholds. No between group differences were found in the cumulative dose of paclitaxel received or in the percentage of patients who had a dose reduction or delay due to PIPN. Three candidate paclitaxel metabolizing genes were DE (i.e., TUBB4B, TUBB2A, RFX2) and two pathways associated with AT were significantly perturbed (i.e., axon guidance, regulation of actin cytoskeleton). This study is the first to provide molecular evidence that a number of axonal transport mechanisms identified in preclinical models of various types of neuropathic pain including chemotherapy-induced peripheral neuropathy are found in breast cancer survivors with persistent PIPN and suggest genes for validation and as potential therapeutic targets.
Traumatic abdominal wall hernia with evisceration secondary to handlebar injury

Abstract We report the case of a 10 year-old male who presented to an outside hospital after falling onto a bicycle handlebar. The patient removed the handlebar embedded in his abdomen and noted bowel protruding from the wound. Upon presentation to the outside facility, he was hemodynamically stable and underwent whole-body CT scan. This demonstrated no hollow viscus, biliary, or vascular injuries. The patient was transferred to our institution where he was brought to the operating room. He underwent exploration, reduction of bowel, and closure of the abdominal hernia. We present a rare case of abdominal evisceration with traumatic hernia secondary to handlebar injury. Our aim with this report is to emphasize the importance of early surgical treatment of this rare phenomenon and to review the relevant literature.
Classifying and inferring behaviors using real‐time acceleration biotelemetry in reproductive steelhead trout (Oncorhynchus mykiss)

Movement behaviors are central to ecology and conservation. Movement sensing technologies can monitor behaviors that are otherwise difficult to observe under field conditions and may enhance the ability to quantify behaviors at the population scale. We monitored steelhead trout (Oncorhynchus mykiss) spawning behaviors in a seminatural enclosure using accelerometer telemetry tags while simultaneously observing behaviors with underwater cameras. Behavioral assignments from visual observations were compared to acceleration histories to develop assignment criteria for acceleration data, including for a key behavior (oviposition). Behavioral events independently classified using acceleration data prior to reviewing video were compared to video scoring and 97% of holding behaviors, 93% of digging behaviors, and 86% of oviposition/covering behaviors were correctly assigned using acceleration data alone. We applied the method to at-liberty steelhead in spawning tributaries. Acceleration records revealed putative spawning and oviposition in at-liberty female steelhead, and time budgets for at-liberty steelhead were similar to those monitored within enclosures. The use of similar movement sensing tags and classification approaches offers a method for monitoring movement behavior, activity budgets, and habitat use in a broad array of aquatic and terrestrial taxa, and may be especially useful when behaviors are cryptic.
Viscous Heating in Compressed Liquid Films

The greatest challenge in high-shear viscometry is the recognition of the difference between constitutive behavior and thermal feedback. The failure to realize this distinction was the cause of a serious mistake which has had a profound effect upon the EHL field for four decades. A traction curve is not a rheological flow curve. The classical approach to EHL has ignored the measurement of viscosity in viscometers at elevated pressures. As a consequence, the field has not benefitted from the understanding gained from directly observing the thermal softening effects of viscous heating. The Eyring sinh-law appears in high-shear viscometry when viscous heating causes thermal softening. The thermal limit of pressurized thin film Couette viscometers with high thermal conductivity cylinders is well-defined by the Nahme–Griffith number. The Spikes and Jie equation overcorrects at low values of the Nahme–Griffith number and undercorrects at high values. The viscous heating in a shear-thinning liquid may cause an apparent transition from power-law to sinh-law above some viscous power. Surprisingly, the sinh-law in this instance extrapolates back to the correct low-shear viscosity. The same response has been observed in one set of NEMD simulations.
Targeting the SAGA and ATAC Transcriptional Coactivator Complexes in MYC-Driven Cancers

Targeting epigenetic regulators, such as histone-modifying enzymes, provides novel strategies for cancer therapy. The GCN5 lysine acetyltransferase (KAT) functions together with MYC both during normal development and in oncogenesis. As transcription factors, MYC family members are difficult to target with small-molecule inhibitors, but the acetyltransferase domain and the bromodomain in GCN5 might provide alternative targets for disruption of MYC-driven functions. GCN5 is part of two distinct multiprotein histone-modifying complexes, SAGA and ATAC. This review summarizes key findings on the roles of SAGA and ATAC in embryo development and in cancer to better understand the functional relationships of these complexes with MYC family members, as well as their future potential as therapeutic targets.
Abdominal Aortic Aneurysm Repair in a Patient with Celiac Artery Occlusion and a Large Inferior Mesenteric Artery

A 75-year-old male with a large infrarenal abdominal aortic aneurysm with 80% stenosis of the celiac artery, mild stenosis of the superior mesenteric artery, a large inferior mesenteric artery (IMA), and an enlarged mesenteric collateral vessel underwent open repair of AAA with reimplantation of the IMA using a Carrel patch.
Prefrontal Network for Executive Control of Cognition and Comportment Including the Executive Control, Salience (Ventral Attention) and Semantic Appraisal (SAN) Networks

The cognitive screening tests or neuroimaging will implicate specific brain regions and their circuitry. Various neurological or neuropsychiatric states or syndromes may present in ways that best fit with a network disturbance (for example, Alzheimer’s along the default mode network and frontotemporal lobe dementia implicating the salience network). Yet others present with much more focal impairment as with expressive Broca’s-type aphasia implicating Brodmann area 44 or Gerstmann’s syndrome due to focal stroke or hemorrhage in the inferior parietal lobule or a Wallenberg’s syndrome due to lateral medullary infarction. Parkinson’s is an example of a state-dependent neurotransmitter-type perturbation secondary to relative dopaminergic deficiency usually ascribed to a substantia nigra degeneration.