cssi/SciSciGPT-SciSciNet huggingface dataset:
A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression

Accumulating evidence suggests that dormant DNA replication origins play an important role in the recovery of stalled forks. However, their functional interactions with other fork recovery mechanisms have not been tested. We previously reported intrinsic activation of the Fanconi anemia (FA) pathway in a tumor-prone mouse model (Mcm4chaos3) with a 60% loss of dormant origins. To understand this further, we introduced a null allele of Fancc (Fancc-), encoding a member of the FA core complex, into the Mcm4chaos3 background. Primary embryonic fibroblasts double homozygous for Mcm4chaos3 and Fancc- (Mcm4chaos3/chaos3;Fancc-/-) showed significantly increased levels of markers of stalled/collapsed forks compared to either single homozygote. Interestingly, a loss of dormant origins also increased the number of sites in which replication was delayed until prophase, regardless of FA pathway activation. These replication defects coincided with substantially elevated levels of genome instability in Mcm4chaos3/chaos3;Fancc-/- cells, resulting in a high rate of perinatal lethality of Mcm4chaos3/chaos3;Fancc-/- mice and the accelerated tumorigenesis of surviving mice. Together, these findings uncover a specialized role of dormant origins in replication completion while also identifying important functional overlaps between dormant origins and the FA pathway in maintaining fork progression, genome stability, normal development and tumor suppression.
Late renal dysfunction in adult survivors of bone marrow transplantation

Until recently long-term renal toxicity has not been considered a major late complication of bone marrow transplantation (BMT). Late renal dysfunction has been described in a pediatric population status post-BMT which was attributable to the radiation in the preparatory regimen. A thorough review of adults with this type of late renal dysfunction has not previously been described. Fourteen of 103 evaluable adult patients undergoing allogeneic (96) or autologous (7) bone marrow transplantation, predominantly for leukemia and lymphomas, at the Medical College of Wisconsin (Milwaukee, WI) have had a syndrome of renal insufficiency characterized by increased serum creatinine, decreased glomerular filtration rate, anemia, and hypertension. This syndrome developed at a median of 9 months (range, 4.5 to 26 months) posttransplantation in the absence of specific identifiable causes. The cumulative probability of having this renal dysfunction is 20% at 1 year. Renal biopsies performed on seven of these cases showed the endothelium widely separated from the basement membrane, extreme thickening of the glomerular basement membrane, and microthrombi. Previous chemotherapy, antibiotics, and antifungals as well as cyclosporin may add to and possibly potentiate a primary chemoradiation marrow transplant renal injury, but this clinical syndrome is most analogous to clinical and experimental models of radiation nephritis. This late marrow transplant-associated nephritis should be recognized as a potentially limiting factor in the use of some intensive chemoradiation conditioning regimens used for BMT. Some selective attenuation of the radiation to the kidneys may decrease the incidence of this renal dysfunction.
Racial disparities in reproductive health outcomes

Racial and ethnic disparities exist in many areas of health care, but the magnitudes of these disparities vary and are not fully understood. In women's health care, disparities in reproductive health outcomes are quite common. In this article, a review was performed to assess the magnitude and reasons for some of the most common disparate reproductive health outcomes, such as infant and maternal mortality, unintended pregnancies, and preventive care. Papers were retrieved by systematically searching OVID-MEDLINE (1966-2002) electronic databases and hand-searching relevant reference lists and bibliographies. Those findings are reviewed here, and some interventions to move toward a reduction of these disparities are suggested. Our review, which contained mostly data on black-white differences, suggest that large disparities continue to exist in many reproductive health outcomes and that collaborative efforts at multiple levels in the community and health care system are needed if we are to effectively close the gaps.
Dynamic Reliability Sensitivity Design of Mechanical Components with Arbitrary Distribution Parameters

The variation rules of strength, load, and reliability of mechanical components are studied with a change in time, and a model is established for dynamic reliability of mechanical components under the random load acting. By combining the theory of reliability design with the method of sensitivity analysis, the computational method of dynamic reliability sensitivity design with arbitrary distribution parameter is proposed based on the methods Edgeworth and perturbation, and the problem of dynamic reliability sensitivity design of mechanical components distributed arbitrary distribution is solved as well as the variation rules of dynamic reliability sensitivity are given. The variation of reliability is studied as design parameters change a little, which provides theoretical data for dynamic reliability design of mechanical components.
An EM-autoradiographic analysis of the projection from cortical areas 17, 18, and 19 to the superior colliculus in the cat

The electron microscopic autoradiographic method was used to identify terminals of axons from cortical areas 17, 18, and 19 in the superficial layers of the superior colliculus. The results show that terminals of area 17 neurons contain round vesicles and made asymmetrical synaptic contacts predominantly onto one or more dendrites or dendritic appendages. Some profiles postsynaptic to labeled terminals contain vesicles and presumably are involved in serial synaptic arrangements. Terminals of area 18 and 19 neurons in the superficial collicular layers appear to comprise two populations, one similar in most respects to area 17 terminals, containing round vesicles and making asymmetrical contacts. The other contains pleomorphic vesicles and makes symmetrical contacts upon dendrites and dendritic appendages. These terminals rarely contact more than one postsynaptic profile, and rarely do the postsynaptic profiles contain vesicles. The two populations of area 18 and 19 terminals containing round and pleomorphic vesicles, respectively, are present in the ratio of approximately 3:1, although this ratio varies throughout the sublaminae of the superficial collicular layers. The presence of two distinct types of cortical terminals in the colliculus suggests that cortical modulation of collicular processing is more complex than was previously conceived.
Electron-ion collision cross sections

Abstract Collisions between electrons and ions are the dominant atomic processes used in predicting the time development of plasmas. The physical model for describing the interactions between electrons and positive ions also has some fundamental differences from that describing the interactions between electrons and neutral particles. This paper is a brief review of these aspects and a description of some techniques for measuring these cross sections.
Delayed Hypercalcemia After Rhabdomyolysis-Induced Acute Renal Failure

Abnormal calcium metabolism is a common complication of rhabdomyolysis-induced acute renal failure. During the oliguric phase, patients are frequently hypocalcemic. Hyperphosphatemia and skeletal resistance to parathyroid hormone are believed to be possible underlying mechanisms. In addition, there have been reports of hypercalcemia during the diuretic recovery phase after rhabdomyolysis. The pathophysiology of the hypercalcemia observed in the recovery phase is a subject of debate. Several mechanisms have been proposed, including mobilization of calcium from muscle deposits, secondary hyperparathyroidism, and elevated levels of 1,25 dihydroxyvitamin D. The authors report the case of a 30-year-old man admitted for evaluation of marked hypercalcemia (18.3 mg/dL) who was hospitalized 3 weeks earlier for acute renal failure secondary to rhabdomyolysis. Plasma parathyroid hormone and 1,25 dihydroxyvitamin D levels were suppressed during the period of maximal hypercalcemia. A technetium pyrophosphate scan demonstrated extensive deposition of calcium throughout the pelvic and lower extremity muscles. This case of delayed hypercalcemia after rhabdomyolysis supports the hypothesis that mobilization of calcium deposits from soft tissue, including muscle, is central to the pathogenesis of this syndrome.
A generalized sine condition and performance comparison of Wolter type II and Wolter-Schwarzschild extreme ultraviolet telescopes

An equation similar to the Abbe sine condition is derived for a Wolter type II telescope. This equation and the sine condition are then combined to produce a so called generalized sine condition. Using the law of reflection, Fermat's principle, the generalized sine condition, and simple geometry the surface equations for a Wolter type II telescope and an equivalent Wolter-Schwarzschild telescope are calculated. The performances of the telescopes are compared in terms of rms blur circle radius at the Gaussian focal plane and at best focus.
No association of sleep with total daily physical activity in normal sleepers

The aim of two studies was to examine both between-subjects and within-subjects associations between daily amounts of physical activity and sleep in the home environment. Study 1 examined self-reported exercise durations and sleep diaries for 105 consecutive days in 31 college students who were normal sleepers. Between-subjects associations of mean exercise with mean sleep were assessed with Spearman rank-order correlations. Within-subjects correlations were determined across 105 days, and by comparing sleep on the 11 most active vs. the 11 least active days. Study 2 examined 71 physically active adults (n=38 ages 18-30 years, and n=33 ages 60-75 years), the majority of whom were normal sleepers. Over seven consecutive days, physical activity was assessed via actigraphy and a diary-derived estimate of energy expenditure, and sleep was assessed via actigraphy and sleep diaries. Between-subjects associations of mean physical activity with mean sleep were assessed with partial correlations, controlling for age. Within-subjects associations were assessed with ANCOVAs, with daily physical activity serving as the covariate, and by comparing sleep on the most active vs. the least active day. No significant within-subjects associations between physical activity and sleep were found in the main analyses of either study. Two small, but significant, between-subjects correlations between different physical activity measures and subjective sleep were found in Study 2. These results fail to support epidemiologic data on the value of exercise for sleep, but are consistent with experimental evidence showing only modest effects of exercise on sleep.
Arthroplasty for cuff tear arthropathy: When half a loaf will do

Cuff tear arthropathy represents a special type of arthritis accompanying massive cuff tears. It is characterized by proximal migration of the humeral head and articulation of the humeral head against the acromion. Traditional shoulder arthroplasty designs have not addressed this humeral-acromial articulation and may be one of the reasons traditional arthroplasty has not worked as well with these patients. A new design based on the adaptive changes seen in cuff tear arthropathy is presented. Rather than trying to force the humeral head to stay centered in the glenoid, this new device accepts the proximal migration of the humerus and seeks to maximize the efficiency of the humeral-acromial articulation and thereby improve the efficiency of the deltoid. Significant improvement in function, pain, motion and patient satisfaction has been achieved with this device with minimal complications. It has performed well in all cases of cuff tear arthropathy with the exception of those patients who have superior escape.
Measurements of the fluctuating pressure at the wall beneath a thick turbulent boundary layer

Measurements of the turbulent pressure field at the wall beneath a thick (5-inch) turbulent boundary layer produced by natural transition on a smooth surface are reported. The data include the mean-square pressure, parallel to the stream, and spatial correlation of the pressure transverse to the stream.The root-mean-square wall pressure was 2.19 times the wall shear stress. The power spectra of the pressure were found to scale with the free-stream speed and the boundary-layer displacement thickness. A few tests with a rough surface showed that the increase in root-mean-square wall pressure was greater than the increase in wall shear stress.The space-time correlation measurements parallel to the stream direction exhibit maxima at certain time delays corresponding to the convection of pressure-producing eddies at speeds varying from 0.56 to 0.83 times the stream speed. The lower convection speeds are measured when the spatial separation of the pressure transducers is small, or when only the pressure fluctuations at high frequencies are correlated. Higher convection speeds are observed when the spatial separation of the pressure transducers is large, or when only low frequencies are correlated. The result that low-frequency pressure fluctuations have the highest convection speed is in agreement with the measurements of Corcos (1959, 1962) in a fully turbulent tube flow. Analysis of these measurements also shows that both large- and small-scale pressure-producing eddies decay after travelling a distance proportional to their scale. More precisely, a pressure-producing eddy of large or small wavelength λ decays and vanishes after travelling a distance of approximately 6λ.The transverse spatial correlation of the wall-pressure fluctuations was measured and compared with the longitudinal scale. Both the transverse and the longitudinal scale of the pressure fluctuations were of the order of the boundary-layer displacement thickness. The transverse and longitudinal scales of both large- and small-scale wall-pressure fluctuations were also measured and were also found to be approximately the same.
Synchrony in neural networks: from physiology to pathology

In the heart, the spatiotemporal chaos of ventricular fibrillation represents a pathological perversion of normal coordinated firing. The contrary is true in the brain, where seizures represent pathological coordinated firing of many neurons. The authors have adapted cellular automata models employed in cardiac research to analyze transitions between desynchronized and synchronized firing. They have then explored these models in progressively more physiologically realistic incarnations.
Does ‘free-sampling’ enhance the value of public goods?

This study investigates whether ‘free sampling’ enhances the value of public goods. Using data from a unique field experiment, we find that the WTP premium effect associated with a brief opportunity to consume a local public good for free is relatively small and temporary. It therefore may not be cost effective to offer free-participation incentives for public goods.
Modified nonparametric approaches to detecting differentially expressed genes in replicated microarray experiments

Motivation: An important goal in analyzing microarray data is to determine which genes are differentially expressed across two kinds of tissue samples or samples obtained under two experimental conditions. Various parametric tests, such as the two-sample t-test, have been used, but their possibly too strong parametric assumptions or large sample justifications may not hold in practice. As alternatives, a class of three nonparametric statistical methods, including the empirical Bayes method of Efron et al. (2001), the significance analysis of microarray (SAM) method of Tusher et al. (2001) and the mixture model method (MMM) of Pan et al. (2001), have been proposed. All the three methods depend on constructing a test statistic and a so-called null statistic such that the null statistic’s distribution can be used to approximate the null distribution of the test statistic. However, relatively little effort has been directed toward assessment of the performance or the underlying assumptions of the methods in constructing such test and null statistics. Results: We point out a problem of a current method to construct the test and null statistics, which may lead to largely inflated Type I errors (i.e. false positives). We also propose two modifications that overcome the problem. In the context of MMM, the improved performance of the modified methods is demonstrated using simulated data. In addition, our numerical results also provide evidence to support the utility and effectiveness of MMM. Contact: weip@biostat.umn.edu
Opportunistic vehicular routing

In a wireless ad hoc network, an opportunistic routing strategy is a strategy where there is no predefined rule for choosing the next node to destination (as it is the case in conventional schemes such as OLSR, DSR or even Geo-Routing). Rather, an intermediate node en route acts in an impromptu fashion and takes a decision that is based solely on current circumstances. A popular example of opportunistic routing is the “delay tolerant” forwarding to “data mules” when a direct path to destination does not exist. Conventional routing in this case would just “drop” the packet. With opportunistic routing, a node acts upon the available information: it seeks the neighbor best qualified to “carry” the packet to destination. If none is available, it will await the right opportunity. This procedure is also known as “data muling” or Delay Tolerant Network (DTN) routing. The Vehicular Ad Hoc Networks (VANET), because of its intrinsic intermittent connectivity (during off peak hours and at night) is an ideal “playground” for opportunistic routing/multicast. In this paper we will examine two examples of VANET opportunistic routing: Delay Tolerant geo-inspired routing and real time video stream multicast of emergency/accident multimedia reports to vehicles in disconnected platoons using network coding.
Manifold regularization and semi-supervised learning: some theoretical analyses

Manifold regularization (Belkin et al., 2006) is a geometrically motivated framework for machine learning within which several semi-supervised algorithms have been constructed. Here we try to provide some theoretical understanding of this approach. Our main result is to expose the natural structure of a class of problems on which manifold regularization methods are helpful. We show that for such problems, no supervised learner can learn effectively. On the other hand, a manifold based learner (that knows the manifold or "learns" it from unlabeled examples) can learn with relatively few labeled examples. Our analysis follows a minimax style with an emphasis on finite sample results (in terms of n: the number of labeled examples). These results allow us to properly interpret manifold regularization and related spectral and geometric algorithms in terms of their potential use in semi-supervised learning.
A comparison of on-demand and table driven routing for ad-hoc wireless networks

We introduce WRP-Lite, which is a table-driven routing protocol that uses non-optimal routes, and compare its performance with the performance of the dynamic source routing (DSR) protocol, which is an on-demand routing protocol for wireless ad-hoc networks. We evaluate the performance of WRP-Lite and DSR for varying degree of mobility and traffic in a 20-node network. The performance parameters are end-to-end delay, control overhead, percentage of packets delivered, and hop distribution. We show that WRP-Lite has much better delay and hop performance while having comparable overhead to DSR.
Surface complexation modeling of Co(II) adsorption on mixtures of hydrous ferric oxide, quartz and kaolinite

Abstract Co sorption was measured as a function of pH, ionic strength (0.001–0.1 M NaNO 3 ) and sorbate/sorbent ratio on pure quartz, HFO and kaolinite and on binary and ternary mixtures of the three solids. Sorption data measured for the pure solids were used to derive internally-consistent diffuse layer surface complexation model (DLM) stability constants for Co sorption. Co sorption on HFO could be adequately modeled over a broad range of ionic strengths and sorbate/sorbent ratios with a two variable-charge site model. Fits based on a single variable-charge site model were reasonable, but were improved by using ionic-strength dependent stability constants. A single variable-charge site model with an additional permanent ion exchange site produced the best fit to Co edges measured on kaolinite over a range of ionic strength and sorbate/sorbent ratios. These DLM fits were also improved by using ionic-strength dependent stability constants. The DLM approach could not adequately describe the slope of Co sorption edges on quartz. This study demonstrates that for accurate prediction of Co sorption over wide ranges of ionic strength and sorbate/sorbent ratio, the DLM may require ionic-strength dependent stability constants. DLM stability constants for Co sorption derived for the pure solids were used to predict sorption as a function of pH and solid concentration on binary and ternary mixtures of the three solids. Discrepancies between predictions and measurements were quantitatively similar to those observed for the pure mineral systems. Thus, a simple component additivity approach provides useful predictions of metal sorption in the mixed solid systems.
Science to Practice: Blood-Brain Barrier Leakage—One Size Does Not Fit All

Radiologists need to increase the sophistication of their thinking about how to assess abnormalities of the blood-brain barrier.
The Impact of Antenna Directivity on the Small-Scale Fading in Indoor Environments

Results obtained from using a geometrically based, single-bounce propagation model are presented to characterize small-scale fading in indoor propagation channels when directional antennas are used. The model is verified by comparing simulated results to measured results. The model is then used to obtain, via simulation, fading statistics for an indoor, line-of-sight channel. The results show that when directive antennas are used, the parameters of the Nakagami- or Rician-distributed small-scale fading vary with separation between the transmit and receive antennas. Furthermore, the strength of the variation depends on antenna directivity. Some physical mechanisms for this effect are discussed
Ground Operations Demonstration Unit for Liquid Hydrogen Initial Test Results

NASA operations for handling cryogens in ground support equipment have not changed substantially in 50 years, despite major technology advances in the field of cryogenics. NASA loses approximately 50% of the hydrogen purchased because of a continuous heat leak into ground and flight vessels, transient chill down of warm cryogenic equipment, liquid bleeds, and vent losses. NASA Kennedy Space Center (KSC) needs to develop energy-efficient cryogenic ground systems to minimize propellant losses, simplify operations, and reduce cost associated with hydrogen usage. The GODU LH2 project has designed, assembled, and started testing of a prototype storage and distribution system for liquid hydrogen that represents an advanced end-to-end cryogenic propellant system for a ground launch complex. The project has multiple objectives including zero loss storage and transfer, liquefaction of gaseous hydrogen, and densification of liquid hydrogen. The system is unique because it uses an integrated refrigeration and storage system (IRAS) to control the state of the fluid. This paper will present and discuss the results of the initial phase of testing of the GODU LH2 system.
15-Epi-lipoxin A4 inhibits human neutrophil superoxide anion generation by regulating polyisoprenyl diphosphate phosphatase 1

Regulation of leukocyte activation is critical to limit unintended tissue injury during acute inflammation. On neutrophil activation, polyisoprenyl diphosphate phosphatase 1 (PDP1) rapidly converts presqualene diphosphate to presqualene monophosphate to facilitate cell activation. Lipoxins are potent anti-inflammatory mediators for neutrophils, yet their counterregulatory signaling mechanisms remain to be determined. 15-Epi-lipoxin A4 (15-epi-LXA4) blocked agonist-initiated association of the nicotinamide adenine dinucleotide phosphate oxidase components p47PHOX and p22PHOX in human neutrophils. 15-Epi-LXA4 (0.1–100 nM) inhibited neutrophil superoxide anion (O2−) generation in a concentration- and ALX/FPR2 receptor-dependent manner that was disrupted by PDP1-specific antibodies. In differentiated HL60 cells, a myeloid cell line, agonist-initiated O2− generation was inhibited by PDP1 siRNA. Recombinant human PDP1 was directly phosphorylated in vitro by select protein kinase C (PKC) isoforms, including PKCβ...
Relationship management with the Millennial generation of public relations agency employees

Abstract This study investigates relationship building with the Millennial generation of public relations agency practitioners from their own perspectives. A recent survey of this population revealed that they have strong relationships with their agency employers, except for a measurement that asked if a long-term bond existed between themselves and their organizations ( Gallicano, Curtin, & Matthews, 2012 ). Consequently, this study explores long-term relationship building with this employee public based on five asynchronous online discussion groups. The conclusion of this study offers theoretical insights about commitment and relationship types. In addition, this study can be helpful to public relations researchers who study Millennials by providing participants’ descriptions of how they characterize their generation of public relations practitioners.
Predictors of successful catheter ablation of ventricular arrhythmias arising from the papillary muscles.

Background Ablation of arrhythmias arising from the papillary muscles (PAPs) is challenging. Objective The purpose of this study was to assess the predictors of successful catheter ablation in patients with ventricular arrhythmias arising from the PAPs. Methods Forty consecutive patients (15 women, mean age 51 ± 14 years, left ventricular ejection fraction 0.46 ± 0.13) with refractory PAP arrhythmias underwent mapping and ablation. Catheter stability was assessed with intracardiac echocardiography. Activation mapping and/or pace mapping were performed to identify the site of origin. Electrophysiological data and anatomic characteristics were assessed in patients with effective versus ineffective ablation. Catheter stability was assessed with intracardiac echocardiography. Results Radiofrequency ablation was acutely effective in eliminating the targeted arrhythmia in 31 patients (78%). The presence of Purkinje potentials at the site of origin of the targeted arrhythmia was associated with an effective outcome (48% vs. 0%; P = .01). The mass of the arrhythmogenic PAPs in the left ventricle was significantly larger in patients with failed versus effective ablation (4.7 ± 2.2 g vs. 2.3 ± 0.6 g; P Conclusion The presence of Purkinje potentials at the site of origin and a smaller size of the PAP are associated with successful ablation of PAP arrhythmias.
Response of stream-breeding salamander larvae to sediment deposition in southern Appalachian (U.S.A.) headwater streams

SUMMARY 1. Increased fine sediment deposition is a prevalent threat to stream biodiversity and has been shown to impact stream-breeding salamanders negatively. However, their complex life histories make it difficult to determine which stage is affected. 2. We conducted field experiments from 26 August to 11 September 2010 and 11 October to 11 November 2010 in two southern Appalachian headwater streams (U.S.A.) to examine the response of larval salamanders to increased fine sediment deposition. Fine sediment was increased in artificial stream channels by 0, 33 and 67%. The number of larvae observed at the end of the experiments was used to determine whether larval microhabitat selection was influenced by fine sediment deposition. A concurrent survey of aquatic larvae in three nearby streams complemented this experiment. Stream substratum composition at survey sites was quantified to examine the effects of fine sediment on larval salamander abundance. 3. Increases in fine sediment deposition failed to explain the number of larval salamanders detected in stream channels. Similarly, a negligible effect of fine sediment was observed on abundance estimates. 4. These results suggest that fine sediment deposition has a minimal impact on aquatic salamander larvae. Therefore, the effects of increased fine sediment loads on stream-breeding salamanders may not be the result of deleterious effects on the aquatic larvae but instead may be the result of effects on other stages. Management efforts that consider these other stages are therefore needed to protect stream-breeding salamander communities.
A selective fluorescent chemosensor for phosphoserine

A fluorescent chemosensor for the detection of phosphoserine is reported. The ditopic sensor features a phosphate-coordinating zinc(II)–dipicolylamine (Zn2+–DPA) unit tethered to an amine-binding coumarin aldehyde fluorophore. With phosphoserine, the sensor demonstrates a 30-fold fluorescence enhancement under buffered aqueous conditions.
GCS: high-performance gate-level simulation with GP-GPUs

In recent years, the verification of digital designs has become one of the most challenging, time consuming and critical tasks in the entire hardware development process. Within this area, the vast majority of the verification effort in industry relies on logic simulation tools. However, logic simulators deliver limited performance when faced with vastly complex modern systems, especially synthesized netlists. The consequences are poor design coverage, delayed product releases and bugs that escape into silicon. Thus, we developed a novel GPU-accelerated logic simulator, called GCS, optimized for large structural netlists. By leveraging the vast parallelism offered by GP-GPUs and a novel netlist balancing algorithm tuned for the target architecture, we can attain an order-of-magnitude performance improvement on average over commercial logic simulators, and simulate large industrial-size designs, such as the OpenSPARC processor core design.
Seasonal Stock Return Patterns In The Seven Industrialized Nations

The paper extends research on the January effect on the G7 countries by evaluating it by decade through 2001. The January effect peaked during the 1970s and is smaller and less common in recent years. The data reveal a marked seasonal return pattern with higher returns in December through May than in June through November. The pattern, not related to the January effect, is more common in recent years.
Upward Mobility and the African American Accountant: An Analysis of Perceived Discrimination, Perceived Career Advancement Curtailment, and Intent to Remain

Accounting studies related to minority issues have focused mainly on gender and public accountants. As a result, the purpose of this study is to investigate perceptions of discrimination and career advancement among African American accountants, the second largest minority group in accounting today, and reveal any differences between males and females. Although research on African American accountants exists, it does not empirically investigate male/female differences related to perceived discrimination (race and gender), perceived career curtailment, and intent to remain. To address this dearth of research focus, this study analyzes survey results from 553 African American accountants, primarily employed in nonpublic accounting organizations. The results suggest females perceive more race and gender discrimination in private industry and other sectors, than in public accounting, and males perceive race discrimination in all three industry types. Females are less likely to remain with their current employ...
Immunochemical characterization of Na+/H+exchanger isoform NHE4

Mammalian Na+/H+ exchangers (NHEs) are a family of transport proteins (NHE1-NHE5). To date, the cellular and subcellular localization of NHE4 has not been characterized using immunochemical techniques. We purified a fusion protein containing a portion of rat NHE4 (amino acids 565-675) to use as immunogen. A monoclonal antibody (11H11) was selected by ELISA. It reacted specifically with both the fusion protein and to a 60- to 65-kDa polypeptide expressed in NHE4-transfected LAP1 cells. By Western blot analysis, NHE4 was identified as a 65- to 70-kDa protein that was expressed most abundantly in stomach and in multiple additional epithelial and nonepithelial rat tissues including skeletal muscle, heart, kidney, uterus, and liver. Subcellular localization of NHE4 in the kidney was evaluated by Western blot analysis of membrane fractions isolated by Percoll gradient centrifugation. NHE4 was found to cofractionate with the basolateral markers NHE1 and Na+-K+-ATPase rather than the luminal marker gamma-glutamyl transferase. In stomach, NHE4 was detected by immunoperoxidase labeling on the basolateral membrane of cells at the base of the gastric gland. We conclude that NHE4 is a 65- to 70-kDa protein with a broad tissue distribution. In two types of epithelial cells, kidney and stomach, NHE4 is localized to the basolateral membrane.
Truncated Physical Model for Dynamic Sensor Networks with Applications in High-Resolution Mobile Sensing and BIGDATA

AbstractHistorically, structural health monitoring (SHM) has relied on fixed sensors, which remain at specific locations in a structural system throughout data collection. This paper introduces state-space approaches for processing data from sensor networks with time-variant configurations, for which a novel truncated physical model (TPM) is proposed. The state-space model is a popular representation of the second-order equation of motion for a multidegree of freedom (MDOF) system in first-order matrix form based on field measurements and system states. In this mathematical model, a spatially dense observation space on the physical structure dictates an equivalently large modeling space, i.e., more total sensing nodes require a more complex dynamic model. Furthermore, such sensing nodes are expected to coincide with state variable DOF. Thus, the model complexity of the underlying dynamic linear model depends on the spatial resolution of the sensors during data acquisition. As sensor network technologies e...
The Importance of being "We": Collective Identity and the Mobilizing Work of Progressive Activists in Hartford, Connecticut

This article examines the ways that collective identity influences the mobilizing work activists perform in a wide variety of progressive activities in Hartford, Connecticut, as reported in open-ended life history interviews. Using a collective identity typology based on ideology, organization, and biography, the analysis demonstrates the variety of ways in which these different "group allegiances" affect how activists raise consciousness, choose strategies and goals, pursue allies, and build coalitions. These myriad differences in mobilizing by activists with different collective identities within the same movement sector speak to the flexibility of social movement structures and to the importance of activist identity in maneuvering within those structures.
Adaptive Beamforming Assisted Decision Feedback Equalization for Millimeter Wave Receivers

Beamforming and equalization are two key, but power hungry functions, essential in a mm-wave receiver. This paper proposes the incorporation of null adaptation and beam steering into the beamformer in order to reduce the length of the time-domain equalizer. The adaptive beamformer spatially filters the received signal field by steering main beam towards the angle of arrival of desired signal and steering nulls towards the angle of arrival of strong multipath components, thereby reducing their adverse effects prior to the DFE. This, in turn, significantly reduces the complexity and hence the power consumption of the DFE. The development of this architecture is closely guided by hardware considerations; in particular, the spatial processing hardware is implemented in the analog baseband domain, while the feedback equalizer is implemented using mixed analog-digital hardware. Adaptation circuitry is implemented using mostly digital hardware. Using this technique, higher data rates can be supported with a given number of elements. Conversely, the number of antennas and/or equalizer taps may be decreased while meeting a given data rate target. Extensive simulations using real mm-wave channel models are presented to support these hypotheses.
Residual Efficacy of Chlorpyrifos-methyl + Bioresmethrin and Chlorpyrifos-methyl + Resmethrin for Controlling Lesser Grain Borers (Coleoptera: Bostrichidae), Rice Weevils (Coleoptera: Curculionidae), and Red Flour Beetles (Coleoptera: Tenebrionidae) in Stored Wheat

Soft red winter wheat was treated with chlorpyrifos-methyl alone or combined with either bioresmethrin or resmethrin (synergized and nonsynergized) and stored for 10 mo under ambient conditions in Savannah, Ga. Every 2 mo, wheat was removed from storage and bioassayed with adult lesser grain borers, Rhyzopertha dominica (F.); rice weevils, Sitophilus oryzae (L.); and red flour beetles, Tribolium castaneum (Herbst). Mortality at 5 d, F1 production, percentage damaged kernels, and dockage weight after 49 d of incubation were determined. Lesser grain borers never survived introduction on wheat treated with bioresmethrin, resmethrin, or either pyrethroid combined with chlorpyrifos-methyl. Rice weevils survived on wheat treated with the pyrethroids and caused considerable damage to the wheat. Both pyrethroids suppressed red flour beetle progeny. Chlorpyrifos-methyl alone or combined with bioresmethrin or resmethrin controlled all three species and protected the wheat for at least 8 mo.
Investigating Lysine Adsorption on Fumed Silica Nanoparticles

The adsorption of amino acids on silica surfaces has attracted considerable interest because it has a broad range of applications in various fields such as drug delivery, solid-phase peptide synthesis, and biocompatible materials synthesis. In this work, we systematically study lysine adsorption on fumed silica nanoparticles with thermal analysis and solid-state NMR. Thermogravimetric analysis results show that the adsorption behavior of lysine in low-concentration aqueous solutions is well-described by the Langmuir isotherm. With ultrafast magic-angle-spinning 1H NMR and multinuclear and multidimensional 13C and 15N solid-state NMR, we successfully determine the protonation state of bulk lysine and find that lysine is adsorbed on silica nanoparticle surfaces through the side-chain amine groups. Density functional theory calculations carried out on lysine and lysine–silanol complex structures further confirm that the side-chain amine groups interact with the silica surface hydroxyl groups via strong hydro...
Economic Status of the Japanese Beetle in 1932

In 1932the Japanese beetle (Popillia japonica) probably caused greater destruction of fruit and produce crops than in any year since its discovery in 1916. A larger number of classified nurseries disclosed infestations than during 1931. Traps distributed in cities and towns outside known infested territory resulted in discovery of a large number of first record infestations at points more remote from the densely infested zone than any heretofore found infested. This does not necessarily indicate a greater spread of the insect in 1932 than in any previous year, but demonstrates that scouting with traps is more efficient than visual scouting by temporarily employed scouts. Survey of southern New Jersey, southeastern Pennsylvania and northern Delaware sections most heavily infested by the beetle disclosed that from 75 to 100 per cent defoliation of preferred food plants took place over an area of 1,647 square miles, that foliage damage of from 50 to 75 per cent was evident in 1,378 square miles, and that evidence of at least 25 per cent foliage injury was observed over an additional area of 1,353 square miles.
Displaying Depth in Computer Systems: Lessons from Two-Dimensional Works of Art

Virtual depth displays depend on static, monocular cues. Models of integrating monocular cues may be continuous (additive) or discontinuous. Previous research using simple displays and a small number of cues supported continuous cue integration. The present research is designed to expand the understanding of how the visual system integrates information from multiple pictorial cues by investigating combinations of one to ten pictorial cues in visually-rich, two-dimensional displays (paintings and photographs). Participants estimated depth in target paintings and photographs relative to a standard two dimensional display. Certain results suggest that the visual system integrates cues in a largely additive way, but after a number of cues are present there may be an additional boost in perceived depth resulting in a best-fittingdiscontinuous model of cue combination. However, this discontinuous effect may be due to designdecisions made by the painters rather than exclusively to the perceptual processes of the...
Case records of the Massachusetts General Hospital. Case 20-2012. A 77-year-old man with leg edema, hematuria, and acute renal failure.

A 77-year-old man was transferred to this hospital because of edema, hematuria, and acute renal failure. A renal biopsy had shown crescentic glomerulonephritis. Diagnostic test results were received, and management decisions were made.
Dual trajectories of maternal parenting stress and marital intimacy during toddlerhood

Parenting stress disrupts both parenting and child adjustment. Marital intimacy is often conceptualized as a source of support that may reduce parenting stress. We examined the association between mothers' trajectories of parenting stress and marital intimacy when their children were 15–36 month old. We also explored whether maternal depressive symptoms at 15 months accounted for individual differences concurrently or in the trajectories of parenting stress and marital intimacy. Mothers' marital intimacy was negatively associated with their concurrent levels of parenting stress and declines in parenting stress over time. Depressive symptoms were associated with 15-month parenting stress and marital intimacy. Overall, intimacy within the marriage appears to be a resource that reduces mothers' parenting stress during the toddler years
New approaches in the treatment of metastatic melanoma: thalidomide and temozolomide.

Both pentostatin (Nipent) and rituximab (Rituxan) have single-agent activity in B-cell malignancies, including indolent and intermediate-grade non-Hodgkin's lymphoma (NHL). Pentostatin is also active in pretreated patients with chronic lymphocytic leukemia (CLL). In spite of current treatment modalities, few patients with these diseases are cured. The combination of rituximab and pentostatin is an attractive treatment option because both drugs have a limited toxicity profile and can be delivered on an outpatient basis. We describe the design of a phase II multicenter study to evaluate the safety and efficacy of pentostatin in combination with rituximab in patients with previously treated and untreated low-grade NHL and CLL.
Two-year longitudinal assessment of physicians’ perceptions after replacement of a longstanding homegrown electronic health record: does a J-curve of satisfaction really exist?

This report describes a 2-year prospective, longitudinal survey of attending physicians in 3 clinical areas (family medicine, general pediatrics, internal medicine) who experienced a transition from a homegrown electronic health record (EHR) to a vendor EHR. Participants were already highly familiar with using EHRs. Data were collected 1 month before and 3, 6, 13, and 25 months post implementation. Our primary goal was to determine if perceptions followed a J-curve pattern in which they initially dropped but eventually surpassed baseline measures. A J-curve was not found for any measures, including workflow, safety, communication, and satisfaction. Only the reminders and alerts measure dropped and then returned to baseline (U-curve); a few remained flatlined. Most dropped and remained below baseline (L-curve). The only measure that remained above baseline was documenting in the exam room with the patient. This study adds to the literature about current controversies surrounding EHR adoption and physician satisfaction.
Spectra for the A = 6 reactions calculated from a three-body resonance model

We develop a resonance model of the transition matrix for three-body breakup reactions of the A = 6 system and present calculations for the nucleon observed spectra, which are important for inertial confinement fusion and Big Bang nucleosynthesis (BBN). The model is motivated by the Faddeev approach where the form of the T matrix is written as a sum of the distinct Jacobi coordinate systems corresponding to particle configurations (α , n -n ) and (n ; n -α) to describe the final state. The structure in the spectra comes from the resonances of the two-body subsystems of the three-body final state, namely the singlet (T = 1) nucleon-nucleon (NN ) anti-bound resonance, and the N α resonances designated the ground state (Jπ = ) and first excited state (Jπ = ) of the A = 5 systems 5 He and 5 Li. These resonances are described in terms of single-level, single-channel R -matrix parameters that are taken from analyses of NN and Nα scattering data. While the resonance parameters are approximately charge symmetric, external charge-dependent effects are included in the penetrabilities, shifts, and hard-sphere phases, and in the level energies to account for internal Coulomb differences. The shapes of the resonance contributions to the spectrum are fixed by other, two-body data and the only adjustable parameters in the model are the combinatorial amplitudes for the compound system. These are adjusted to reproduce the observed nucleon spectra from measurements at the Omega and NIF facilities. We perform a simultaneous, least-squares fit of the tt neutron spectra and the 3 He3 He proton spectra. Using these amplitudes we make a prediction of the α spectra for both reactions at low energies. Significant differences in the tt and 3 He3 He spectra are due to Coulomb effects.
Disability and the Love of Wisdom: De-forming, Re-forming, and Per-forming Philosophy of Religion

My goal in this chapter is to interrogate traditional approaches to philosophy of religion and philosophical theology from a disability studies perspective, rethinking along the way issues in theodicy, religious epistemology, and questions of death and the afterlife that are commonly treated in traditional textbooks on philosophy of religion. This is a conversation whose time is long overdue, as disability perspectives have been noticeably absent in even the most recent discussions in the philosophy of religion.2 Hence I refrain at this point in the Introduction from justifying this project, with the hope that its importance and timeliness will have emerged for readers at the end. Along the way, I will argue that when the human experience of disability interfaces with the philosophical discussion of religion, one of the results is a “performative philosophy of religion” whereby philosophical reflection does not exclude the speculative moment but is an activity that shapes human dispositions, activities, and political life.