cssi/SciSciGPT-SciSciNet huggingface dataset:
Quantification of surgical technique using an inertial measurement unit.

BACKGROUND Quantifying the algorithmic information content of hand motion patterns during a surgical task enables the comparison of different groups, novice and expert. Previously, we have shown that the information content/complexity of hand motion patterns during the surgical skill/subtask of knot tying reduces with increased expertise (J Surg Educ 2012;69:306-310). We therefore hypothesized that the information content/complexity of motion patterns would also reduce with expertise during a more complex surgical task of a bench model venous anastomosis. METHODS A custom inertial measurement unit was used to record 6-degrees of freedom hand motion from the right hand during a low-fidelity bench model venous anastomosis. Data were obtained from 2 groups as follows: novice (surgical residents, postgraduate year 1 and 2) and expert (attending surgeons). Each data set from the surgical task was processed into a symbolic time series from which the algorithmic entropy measure Lempel-Ziv complexity was calculated. A Student t test was used to test whether the 2 groups were sampled from the same population when using this metric, applying a P value of 0.05 to reject the null hypothesis. RESULTS The expert surgeons had more complex patterns of motion compared with novice surgeons during this surgical task. This was statistically significant using the Lempel-Ziv complexity metric (P = 0.01). CONCLUSIONS The hypothesis that increased surgical experience would reduce the complexity of hand motion patterns was not found to be true during this surgical task, and the opposite was found to be true. An alternative hypothesis that would combine the previous finding of a reduction in complexity of a subtask with this study's finding of increasing complexity of the whole task with increasing surgical expertise could be due to a hierarchy of pattern structure: experts use simpler subtask motifs in more complex and denser patterns.
Entanglement negativity in free-fermion systems: An overlap matrix approach

In this paper, we calculate the entanglement negativity in free-fermion systems by use of the overlap matrices. For a tripartite system, if the ground state can be factored into triples of modes, we show that the partially transposed reduced density matrix can be factorized and the entanglement negativity has a simple form. However, the factorability of the ground state in a tripartite system does not hold in general. In this situation, the partially transposed reduced density matrix can be expressed in terms of the Kronecker product of matrices. We explicitly compute the entanglement negativity for the Su-Schrieffer-Heeger model, the integer Quantum Hall state, and a homogeneous one-dimensional chain. We find that the entanglement negativity for the integer quantum Hall states shows an area law behavior. For the entanglement negativity of two adjacent intervals in a homogeneous one-dimensional gas, we find agreement with the conformal field theory. Our method provides a numerically feasible way to study the entanglement negativity in free-fermion systems.
Dissipation factor an in process tool for magnet wire coating applications

The inherent properties (chemical, physical, thermal and electrical) of magnet wire enamels depend to a great extent on the degree of cure these enamels undergo during tower application. In the past, relatively simple tests such as solvent resistance and flexibility existed to determine the parameters of application versus degree of curing. These tests, being of short duration, allowed little copper scrap to generate during start up of production equipment. Today a host of new complex polymers are being applied as magnet wire coatings. The markets they are serving are more complex and demanding and require a greater degree of sophistication in establishing an optimum degree of cure. Existing tests that define these qualities are quite often refined and time consuming. Due to these factors and higher material application costs in today's magnet wire industry, increasing emphasis is being placed on application knowledge. A definite need exists to control enamelling conditions and subsequently insure that satisfactory enamelled magnet wire is being produced at all times.
Analysis on Potential Rise on UHV Oil-paper Capacitor Bushing's End Shield Under Lightning Impulse Test

To analyze the reason that slight C2H2 dissolved in oil of ultra-high voltage(UHV) oil-paper capacitor bushing after lightning impulse tests,the three-ratio method was adopted to analyze the oil chromatographic data,and lower energy discharges occurring in the bushing were verified.Disassembly of the bushing indicated that the outlet wire was partly broken and there were some discharge marks on the outlet wire and pedestal.Therefore,the potential rise in the end shield was taken into account to explain the possible discharge cases.By measuring the high-frequency impedance of grounding line and current waveforms,the potential rise was estimated.The results demonstrate that the impedance of the grounding line in high frequency is much higher than that in power frequency,which is an important reason of the potential rise during the impulse test.In tests with the chopped lightning impulse,the potential rise in the end shied is up to 41 kV.It is concluded that some measures should be adopted in lightning impulse tests to avoid similar faults,including increasing the sectional area,decreasing the length of the ground lines,and taking one point to grounding.
The Status of Laboratory Medium Quality Control about Ya'an Microbial Disease Control and Prevention

Objective To analyze disease prevention and control system in Ya'an medium quality control microbiology laboratory situation,in order to improve the detection level of microbiological examination of the system for disease prevention and control research and provide a scientific basis.Methods Based on SN/T1538.1-2005 relevant content on the scientific analysis of data obtained.Results Nine microbiology laboratory survey,manufacturers reported rate of 76.49% obtained,acceptance and opening rate of 58.20% using the records,preparation of record was 80.22 percent,the standard rate of 7.46% strain verification,pollution testing was 86.19 %,pH test was 93.50%,85.85% sterilization records.Conclusion Results seem,the city CDC microbiology laboratory quality control status of the medium is not satisfactory,especially in the standard medium strain verification rate of only 7.46%,almost at a standstill,in the future work should cause us enough attention.
A Novel Image Encryption Scheme with 2D-Logistic Map and Quadratic Residue

Considering the importance of image transmission in the public net,a new image encryption algorithm w as proposed based on the 2D-Logistic chaos and quadratic residue. Firstly, the original image w as shuffled tw ice w ith the 2D-Logistic chaos map,and the positions of the original image w ere changed sufficiently. Then, the shuffled image w as turned into a binary sequence,and every 8 bits w ere called a block. For each block, quadratic residue w as applied to encrypt the block, then, the encrypted binary sequence w as turned into the encrypted image. Therefore,the statistical information of plain image w as changed drastically by the proposed scheme. The proposed image scheme w as tested by various types of experiment and security analyses such as histogram analysis, information entropy, key sensitivity and correlation coefficient analysis. All these analyses demonstrated that the proposed scheme can resist statistical attack, information entropy attack, and it is very proper for secure image communication.
Abstract A175: Design and evaluation of novel natural killer cell chimeric antigen receptors

Chimeric Antigen Receptors (CARs) are used to direct and activate cytotoxic lymphocytes against virally infected or malignant cells. They have been heavily investigated in cytotoxic T cells, and, to a much lesser extent, in natural killer (NK) cells with promising results, especially for anti-CD19 CARs to mediate killing of B cell leukemias. To date, CARs that have been utilized in NK cells have primarily employed the same intracellular signaling components as T cell CARs. However, this may not be the optimal approach for CAR-expressing NK cells due to differences in key signaling pathways. To improve the activity of NK cell-CARs targeted against solid tumors, the intracellular signaling domains of an anti-mesothelin CAR were modified to express NK cell specific signaling molecules and evaluated for activity in NK-92 cells against ovarian cancer cell lines. CARs were assembled using gBlocks encoding various transmembrane, co-activating, and signaling domains. NK cell specific CARs were then transfected into NK-92 cells, a human NK cell tumor line, using Sleeping Beauty. Positive cells were selected for using a drug resistance marker and CAR surface expression was evaluated using flow cytometry. CAR expressing NK-92 cells were then evaluated for degranulation, as indicated by CD107a production, and interferon (INF)-γ release when challenged with mesothelin negative, MA148, and mesothelin positive, A1847, ovarian cell lines. In addition, beads conjugated to mesothelin were used to measure NK cell activation via the CAR alone. In total 10 novel CARs were assembled and transfected into NK-92 cells, 6 of which were properly expressed on the cell surface. All 6 properly expressed CARs enhanced both CD107a and INF-γ production. When CAR activity alone was evaluated using mesothelin conjugated protein A beads, non-transfected NK-92 cells or cells that did not properly express the CAR all had Citation Format: David L. Hermanson, Branden Moriarity, Trevor Argall, Melissa A. Geller, David Largaespada, Dan S. Kaufman. Design and evaluation of novel natural killer cell chimeric antigen receptors. [abstract]. In: Proceedings of the CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference: Translating Science into Survival; September 16-19, 2015; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(1 Suppl):Abstract nr A175.
Measuring and optimizing android smartwatch energy consumption: poster

Smartwatches are operating under tight energy constraints. In this paper, we describe our on-going work on measuring and optimizing Android smartwatch energy consumption. We derived power models for commodity smartwatches, and then applied the power model to an IRB-approved user study involving 30 smartwatch users. We then propose research ideas on improving energy efficiencies for Android smartwatches.
Alcohol Production by Fish Spoilage Bacteria

Bacterial isolates (244) identified to genera were tested for their ability to produce ethanol, isopropanol and propanol in a fish tissue extract. All of the isolates produced ethanol and 241 and 227 produced isopropanol and propanol, respectively. One high alcohol producing member of each of the groups Moraxella -like, Pseudomonas , Flavobacterium , Micrococcus and coryneforms was selected for utilization of fish components as substrates in production of alcohol. The substrates tested included four sugars, nine amino acids and lactic and pyruvic acids. Although there were some variations in the levels of alcohols produced by the test organisms from the substrates, the organisms appeared to prefer simple 5 and 6 carbon sugars and then utilized the free amino acids. The level of oxygenation greatly affected the levels of alcohols produced.
Promoting Clinical Legal Education and Democracy in India

Clinical legal education emerged in the United States in the 1960s to give valuable skill-based instructions to law students while providing legal services to people who could not otherwise afford them. This essay proposes another reason why both Indian and American law schools should support the development of law clinics. Drawing on the works of John Dewey and Martha Nussbaum, I argue that clinical legal education promotes democracy. Both elite American and Indian universities are largely unrepresentative of the respective population demographics of their countries. In clinics, law students bridge this divide by undertaking representation for people from different racial, caste, and income backgrounds than themselves. These exchanges generate empathy and knowledge among students about the challenges marginalised groups in the society face. Consequently, they learn to recognise other citizens as equals and to formulate policies that will enhance the welfare of society as a whole. There is an urgent need to formalise clinical legal education programs in Indian law schools both for purposes of enhancing the democracy as well as providing skill-based training to law students and much-needed legal services to the poor.
Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

Increased collagen deposition by breast cancer (BC)-associated mesenchymal stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are unknown. Here, we report that the collagen receptor discoidin domain receptor 2 (DDR2) is essential for stromal-BC communication. In human BC metastasis, DDR2 is concordantly upregulated in metastatic cancer and multipotent mesenchymal stromal cells. In MSCs isolated from human BC metastasis, DDR2 maintains a fibroblastic phenotype with collagen deposition and induces pathological activation of DDR2 signaling in BC cells. Loss of DDR2 in MSCs impairs their ability to promote DDR2 phosphorylation in BC cells, as well as BC cell alignment, migration, and metastasis. Female ddr2-deficient mice homozygous for the slie mutation show inefficient spontaneous BC metastasis. These results point to a role for mesenchymal stem cell DDR2 in metastasis and suggest a therapeutic approach for metastatic BC.
Rex Lee Jim's 'Na'asts'o?o?sí: On iconicity, interwoven-ness, and ideophones

This article explores the ways that Navajo poet Rex Lee Jim uses ideophony in one of his poems. I argue that Jim’s use of an ideophone in its myriad forms (from nominalized noun to independent ideophone to verb stem) creates an interwoven-ness across lines that evokes an iconicity of sound and sense. I begin by describing something of the grammatical structuring and uses of Navajo ideophony. I then turn to a discussion of contemporary written Navajo poetry that uses ideophony and especially Jim’s poetry. I follow this with a discussion of the use of Navajo ideophony in literacy education and in competing views about the appropriateness of using ideophony in Navajo written literature.
Abstract P3-04-12: Both spliced and unspliced XBP1 regulates breast cancer cell fate response to antiestrogen via NFkappaB signaling

Unfolded protein response (UPR), a stress-induced survival mechanism, may be used by cancer cells to avoid cell death. Antiestrogen therapy, widely applied in the treatment of estrogen receptor-positive (ER+) breast cancer, induces endoplasmic reticulum stress (EnR stress) that leads to activation of each of the three arms of the UPR. One critical prosurvival activator that is regulated by two arms of the UPR is the transcription factor X-box binding protein 1 (XBP1). XBP1 exists in two isoforms, the transcriptionally inactive unspliced XBP1(U) and the spliced, active XBP1(S). Overexpression of XBP1(S) confers estrogen independence and antiestrogen resistance in ER+ breast cancer cells and XBP1(S) expression correlates with poor clinical responsiveness to Tamoxifen in ER+ breast tumors. However, the underlying signaling mechanisms regulated by XBP1, which may mediate its effects on antiestrogen resistance, are unknown. We show that depletion of endogenous XBP-1 by siRNA increases apoptosis, decreases autophagy, requires down-regulation of p65/RelA, a component of the pro-survival NFκB complex. Using novel spliced and non-spliceable forms of XBP1, we show that XBP1(U) and XBP1(S) both regulate NFκB activity via ERα signaling in breast cancer cells. XBP1(S), but not XBP1(U), also can regulate p65/RelA expression independent of ERα. Antiestrogen resistance as conferred by XBP1 overexpression in MCF-7 cells requires the activation of NFκB signaling; inhibition of NFκB signaling by either the small molecule NFκB inhibitor Parthenolide or p65/RelA siRNA sensitizes XBP1 overexpressing cells to Tamoxifen. The activation of XBP1 and the downstream NFκB signaling is likely to contribute to the TMEM33 overepxression induced apoptosis, as both NFκB signaling and XBP1(S) are elevated in TMEM33 overexpressed MCF7 cells. Thus, we have identified a critical regulatory link between the UPR/XBP1 pathway and pro-survival NFκB signaling that is a major contributor to endocrine responsiveness in ER positive breast cancer. Citation Format: Clarke R, Hu R, Warri A, Jin L, Zwart A, Riggins R, Fang H-b. Both spliced and unspliced XBP1 regulates breast cancer cell fate response to antiestrogen via NFkappaB signaling [abstract]. In: Proceedings of the 2016 San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P3-04-12.
On the Dynamics of Local Linear Model Networks with Orthonormal Basis Functions

Abstract This paper deals with local linear model networks for nonlinear system identification. It compares the standard nonlinear autoregressive with exogenous input (NARX) model structure with the new nonlinear orthonormal basis functions (NOBF) model structure. In particular, the dynamics of interpolated local ARX and OBF models are studied and significant advantages for the NOBF approach are pointed out. Furthermore, the dynamic effect of scheduling variables in local linear model networks based on OBFs is investigated. It is concluded that the NOBF approach is a promising alternative for nonlinear system identification and deserves more attention in the future.
Ravenous wolves revisited: a systematic review of offending concentration

Numerous studies have established that crime is highly concentrated among a small group of offenders. These findings have guided the development of various crime prevention strategies. The underlying theme of these strategies is that by focusing on the few offenders who are responsible for most of the crime, we can prevent the greatest amount of crime with the fewest resources. Nevertheless, there has been no systematic review of the many studies, so it is possible that the accepted understanding among researchers and practitioners is based on a few prominent studies that are misleading. Further, we do not know how concentrated crime is among offenders, given the variety of ways researchers report their findings. This paper systematically reviews this literature and uses meta-analysis to determine how confident we can be that crime is concentrated among a few offenders. We first systematically reviewed the literature and found 73 studies on the concentration of crime among offenders. From those studies, we identified 15 studies on the prevalence of offending and 27 studies on the frequency of offending that provided data suitable for analysis. We then performed a meta-analysis of those studies to examine how crime is concentrated among the worst offenders and how that concentration varies between different types of offenders. We found that crime is highly concentrated in the population and across different types of offenders. Little variation in concentration exists between youths and adults or between American offenders and those from other countries. We found more variation between males and females in the concentration of offending, though we believe this may be due to the more limited data on female offenders. The systematic review and meta-analysis we present here is the first study of its kind on offending concentration. This is an important step in closing this gap in the crime prevention literature, but we encourage making updates to this systematic review as new literature becomes available, and using alternate methods of summarizing these studies that could challenge these findings.
Project for Return and Opportunity in Veterans Education (PROVE): An Innovative Clinical Social Work Field Education Model

Veterans transitioning from the military to college life and the unique issues impacting them are an area of clinical social work that has yet to be fully explored in the literature. Project for Return and Opportunity in Veterans Education (PROVE) is an innovative social work field education model that trains first year graduate interns to serve student veterans on college campuses in a non-traditional, milieu setting. PROVE uses a strengths-based, resiliency focus to emphasize the unique characteristics of the student veteran. The model affords the intern a clinical skill set applicable to working with veterans in various social work agencies. This article will discuss the history, framework and implementation of the PROVE model, use of Veteran-Affirmative Counseling (VAC) and the unique milieu setting. The article will conclude with implications for clinical social work practice field education settings and recommendations for replicability of the PROVE model.
A Lattice-Based Smoother for Regions With Irregular Boundaries and Holes

ABSTRACTWe consider the problem of estimating a smooth function over a spatial region that is delineated by an irregular boundary and potentially contains holes within the boundary. Methods commonly used for spatial function estimation are well-known to suffer from bias along such boundaries. The estimator we propose is a kernel regression estimator, where the kernel is an approximation to a two-dimensional diffusion process contained within the region of interest. The diffusion process is approximated by the distribution of length-k random walks originating from each observation location and constrained to stay within the domain boundaries. We propose using a cross-validation criterion to find the optimal walk length k, which controls the smoothness of the resulting estimate. Simulations show that the method outperforms the soap film smoother of Wood, Bravington, and Hedley in many realistic scenarios, when data are noisy and borders are highly irregular. We illustrate the practical use of the estimator ...
Tobacco-Smoke Incursions and Satisfaction Among Residents With Children in Multiunit Housing, United States, 2013.

Objectives:Residents of multiunit housing can be exposed to tobacco smoke even if they do not permit smoking in their homes. Although even low levels of tobacco smoke exposure can cause health problems for children and adults, some landlords are reluctant to ban smoking for fear of decreased occupancy rates or tenant satisfaction. The objective of this study was to assess the impact of tobacco smoke-free policies and tobacco-smoke incursions on housing satisfaction in multiunit housing residences with children.Methods:In 2013, 3696 randomly sampled US adult multiunit housing dwellers were invited to participate in a survey, and 3253 (88%) participated. Of these, 3128 responded to the question about having a child in the home, and 835 (27%) reported having a child in the home. We collected data on demographic characteristics, tobacco-smoke incursions, knowledge and attitudes about smoking policies, and housing satisfaction for this sample of 835 residents.Results:Of the 827 residents who responded to the q...
Hyperstructured Illumination with Metamaterial Disorder

Hyperstructured illumination, a super-resolution scheme based on structured illumination in hyperbolic media, must account for material disorder. We show that even with no information on disorder, the method allows for accurate image reconstruction.
Substance and Symbol

Alcohol is discussed as a core symbol of American culture. The language associated with alcohol, other “substances,” and their widely shared folklore are shown to underlie the official “disease” model of alcoholism and treatment. The cultural psychology that gives the disease model its plausibility and experiential validity is discussed. Similar to “possession” theories in other societies, in American alcoholism the “not-me” is seen as overtaking the normal, social “me,” inducing states of drunkenness if not chronic disease. This depersonalizing creates a paradox: requiring control from one held to be out of control by virtue of the disease process.
Free-standing liquid membranes as unusual particle separators

Separation of substances is central to many industrial and medical processes ranging from wastewater treatment and purification to medical diagnostics. Conventional solid-based membranes allow particles below a critical size to pass through a membrane pore while inhibiting the passage of particles larger than that critical size; membranes that are capable of showing reversed behavior, that is, the passage of large particles and inhibition of small ones, are unusual in conventional engineering applications. Inspired by endocytosis and the self-healing properties of liquids, we show that free-standing membranes composed entirely of liquid can be designed to retain particles smaller than a critical size given the particle inertial properties. We further demonstrate that these membranes can be used for previously unachievable applications, including serving as particle barriers that allow macroscopic device access through the membrane (for example, open surgery) or as selective membranes inhibiting gas/vapor passage while allowing solids to pass through them (for example, waste/odor management).
SU(1,1) parity and strong violations of a Bell inequality by entangled Barut-Girardello coherent states

We study the violations of the Bell–Clauser–Horne–Shimony–Holt inequality for entangled SU(1,1) Barut–Girardello coherent states. As in a previous paper where violations of the inequality were studied for entangled SU(1,1) coherent states of the Perelomov form [Phys. Rev. A.93, 042104 (2016)PLRAAN1050-294710.1103/PhysRevA.93.042104], we choose as our observable the SU(1,1) parity operator, though here we discuss the physical meaning of the operator for single-mode and two-mode bosonic realizations of the su(1,1) Lie algebra. We show that the SU(1,1) parity operator is not the same as the usual photon number parity operator but rather is a form of higher-order photon number parity. Distant observers Alice and Bob perform on each of their subsystems non-compact SU(1,1) transformations characterized by hyperbolic angles, followed by measurements of the SU(1,1) parity operators. We find strong violations of the inequality over a wide range of parameters, and these violations are stronger than those that can be obtained by the entangled Perelomov SU(1,1) coherent state.
When Weather Forecasters Are Wrong: Image Repair and Public Rhetoric After Severe Weather:

Weather forecasts are a unique type of prediction rhetoric—science communication with inherent uncertainty and multiple potential interpretations from diverse audiences. When forecasts are wrong, a...
Mechanical Interactions between a Cell and an Extracellular Environment Facilitate Durotactic Cell Migration

Cell migration is a fundamental process in biological systems, playing an important role for diverse physiological processes. Cells often exhibit directed migration in a specific direction in response to various types of cues. In particular, cells are able to sense the rigidity of surrounding environments and then migrate towards stiffer regions. To understand this mechanosensitive behavior called durotaxis, several computational models have been developed. However, most of the models made phenomenological assumptions to recapitulate durotactic behaviors, significantly limiting insights provided from these studies. In this study, we developed a computational biomechanical model without any phenomenological assumption to illuminate intrinsic mechanisms of durotactic behaviors of cells migrating on a two-dimensional substrate. The model consists of a simplified cell generating contractile forces and a deformable substrate coarse-grained into an irregular triangulated mesh. Using the model, we demonstrated that durotactic behaviors emerge from purely mechanical interactions between the cell and the underlying substrate. We investigated how durotactic migration is regulated by biophysical properties of the substrate, including elasticity, viscosity, and stiffness profile.
Agent-based discrete-event simulation model for no-notice natural disaster evacuation planning

Abstract Over the past century, natural disasters have been often large-scale and overwhelming catastrophes resulting in irreparable and uncontrollable damage. In order to decrease the average evacuation travel time and reduce casualties, as well as improve the medical care for vulnerable populations in natural disasters, it is worthwhile to look at strategic disaster evacuation planning. In this paper, an agent-based discrete-event simulation (ABDES) modeling framework based on an embedded GIS module is developed for making no-notice natural disaster evacuation planning and improving the evacuation strategy periodically by using the proposed simulation model. Furthermore, in order to examine the applicability and extensibility of the proposed integrated GIS-based ABDES modeling framework, we conduct the experiments using several practical scenarios based on the city of San Francisco in California. The proposed evacuation simulation modeling framework can offer decision-makers significant insight on the traffic assignment and the configuration of resources such as evacuation vehicles and relief facilities that are required to complete successfully an evacuation against the no-notice large-scale disasters.
Conic Approximation with Provable Guarantee for Traffic Signal Offset Optimization

We consider the offset optimization problem that coordinates the offsets of signalized intersections to reduce vehicle queues in large-scale signalized traffic networks. We adopt a recent approach that transforms the offset optimization problem into a complex-valued quadratically-constrained quadratic program (QCQP). Using the special structure of the QCQP, we provide a π /4-approximation algorithm to find a near-global solution based on the optimal solution of a semidefinite program (SDP) relaxation. Although large-scale SDPs are generally hard to solve, we exploit sparsity structures of traffic networks to propose a numerical algorithm that is able to efficiently solve the SDP relaxation of the offset optimization problem. The developed algorithm relies on a tree decomposition to reformulate the large-scale problem into a reduced-complexity SDP. Under the practical assumption that a real-world traffic network has a bounded treewidth, we show that the complexity of the overall algorithm scales near-linearly with the number of intersections. The results of this work, including the bounded treewidth property, are demonstrated on the Berkeley, Manhattan, and Los Angeles networks. From numerical experiments it is observed that the algorithm has a linear empirical time complexity, and the solutions of all cases achieve a near-globally optimal guarantee of more than 0.99.
Discrimination and Classification, Round 1

Discriminant analysis and related methods, treated in Chapters 5 to 7, are the central topics of this course. Chapter 5 gives an introduction on a mostly descriptive level, ignoring questions of statistical inference. The mathematical level of Chapter 5 is moderate, and all concepts are explained at great length, hoping that even students without a strong mathematical background will be able to master most of the material. Chapter 6 gives an introduction to problems of statistical inference that arise naturally from the setup of discriminant analysis: testing for equality of mean vectors, confidence regions for mean vectors, and related problems for discriminant functions. Then Chapter 7 resumes the classification theory on a more abstract level and gives brief introductions to related topics, such as logistic regression and multivariate analysis of variance.
OUTCOMES OF PREGNANCY IN WOMEN WITH LEFT VENTRICULAR NONCOMPACTION

Left ventricular noncompaction (LVNC) is an inherited cardiomyopathy characterized by prominent left ventricular trabeculations and deep intertrabecular recesses. LVNC is associated with an increased risk of arrhythmia, embolic events, and heart failure. There is limited information regarding
Fibrinogen Columbus II: A novel c.1075G>T mutation in the FGG gene causing hypodysfibrinogenemia and thrombosis in an adolescent male

Hypodysfibrinogenemia, the least frequently reported congenital fibrinogen disorder is characterized by low circulating levels of a dysfunctional protein, and is associated with phenotypic features of both hypo- and dysfibrinogenemia. Herein, we report an adolescent male with unprovoked venous thromboembolism and hypodysfibrinogenemia. Patient had recurrent, progressive thrombosis despite therapeutic anticoagulation with both low molecular weight heparin and warfarin. He had clinical and radiological improvement after transition to a direct thrombin inhibitor. Sequencing of the FGG gene identified a novel heterozygous mutation, c.1075G>T. Structural visualization of the identified variant was pursued and suggested that the mutation likely destabilizes the Ca2+ -binding site of fibrinogen resulting in pathogenicity.
General β‐Jacobi Corners Process and the Gaussian Free Field

We prove that the two-dimensional Gaussian free field describes the asymptotics of global fluctuations of a multilevel extension of the general β-Jacobi random matrix ensembles. Our approach is based on the connection of the Jacobi ensembles to a degeneration of the Macdonald processes that parallels the degeneration of the Macdonald polynomials to the Heckman-Opdam hypergeometric functions (of type A). We also discuss the β ∞ limit. © 2015 Wiley Periodicals, Inc.
Design and Optimization of a Renewable-Energy Fully-Hybrid Power Supply System in Mobile Radio Access Networks

The worldwide continuous growth of mobile subscriptions and broadband data demand is leading to an increase in hardware complexity of the base stations making up the mobile Radio Access Networks (RAN). This technological trend will inevitably result in increasing RAN energy consumption. In addition, the electrical grid accessibility issues encountered in developing countries bring a serious concern for telecom carriers who are constantly looking to reduce their networks operating expenditure (OPEX). Regular periodic maintenance and fuel consumption of on-site Diesel Generators are one of the main contributors to RAN OPEX. In this paper, an exhaustive yet compact model of a radio base stationâ€™s running cost is first introduced to provide telecom carriers a mathematical tool to estimate accurately their overall expenditure. Secondly, a generic Design & Optimization MATLAB tool is developed to minimize this cost by introducing, to the existing grid-generator solutions, renewable-energy (RE) sources to form a fully-hybrid power supply system (HPSS). CO2 emission is also integrated into the previous model to form a compound objective function for optimization. Finally, to achieve an optimal power supply system with both minimum annual OPEX and CO2 emissions, the core algorithm of this work computes the target duty-partition configuration among RE sources, on-site Diesel generators and utility grid. The software outputs in addition the required system design parameters for the RE sources to be installed on site.
Educational Attainment Better Increases the Chance of Breast Physical Exam for Non-Hispanic Than Hispanic American Women: National Health Interview Survey

Background: The Minorities’ Diminished Returns (MDRs) theory suggests that the health effect of educational attainment is considerably smaller for members of racial and ethnic minority groups than for Whites. Objective: The current study explored the racial and ethnic differences in the association between educational attainment and Breast Physical Exam (BPE) among women in the U.S. Methods: The National Health Interview Survey (NHIS 2015) included 12 510 women who were Hispanic or non-Hispanic Black or White people. The independent variable was the level of educational attainment. The dependent variable was lifetime BPE. Age, region, marital status, and employment were the covariates. Race and ethnicity were the focal moderators. Logistic regressions were used for data analysis. Results: Overall, higher educational attainment was associated with higher odds of BPE, net of all confounders (odds ratio [OR]=1.11, 95% CI=1.09-1.13). Ethnicity showed a significant statistical interaction with educational attainment on BPE (OR=0.96, 95% CI=0.93-1.00), which was suggestive of a smaller effect of high education attainment on BPE for Hispanic than non-Hispanic women. The same interaction could not be found for the comparison of White and Black women (OR = 0.98, 95% CI =0.94-1.02). Conclusion: In line with other domains, non-Hispanic White women show a larger amount of health gain from their educational attainment than Hispanic women. It is not ethnicity or class but ethnicity and class that shapes how people engage in pro-health behaviors. This result may help hospitals and healthcare systems to better reduce health disparities in their target populations.
Abstract 21: Heart Failure and Shared Decision-making: Patients’ Perspectives Regarding Medication-related Cost Discussions

Background: Patients with heart failure with reduced ejection fraction (HFrEF) take on average 6 medications daily and can face considerable out-of-pocket medication costs. This issue has become pa...
A Finite-Deformation Constitutive Model of Particle-Binder Composites Incorporating Yield-Surface-Free Plasticity

We present a quasi-static constitutive model for particle-binder composites which accounts for finite-deformation kinematics, non-linear elasto-plasticity without apparent yield, cyclic hysteresis and progressive stress-softening before the attainment of stable cyclic response. The model is based on deformation mechanisms experimentally observed during cyclic compression of Plastic-Bonded Explosives (PBX) at large strain. An additive decomposition of strain energy into elastic and inelastic parts is assumed, where the elastic response is modeled using Ogden hyperelasticity while the inelastic response is described using yield-surface-free endochronic plasticity based on the concepts of internal variables and of evolution or rate equations. Stress-softening is modeled using two approaches; a discontinuous isotropic damage model to appropriately describe the softening in the overall loading-unloading response, and a material scale function to describe the progressive cyclic softening until cyclic stabilization. Finally, a nonlin-ear multivariate optimization procedure is developed to estimate the elasto-plastic model parameters from nominal stress-strain experimental cyclic compression data, and a sensitivity analysis is conducted to quantify the influence of these parameters on the cyclic response.
Build orientation dependent microstructure in polymer laser sintering: Relationship to part performance and evolution with aging

Abstract Laser sintering (LS) is widely used to produce functional polymeric parts; however, the resulting parts are often limited by their porous structure, and performance of the part may be strongly anisotropic. Relating the structural features of parts to build process conditions or powder feedstock has been explored previously. In contrast, little is known regarding how the unique internal structures of LS parts evolve and relate to their performance later in their life cycle, for example, after use in a real-world operating environment. Here, a tightly controlled LS build process and measurement campaign by standard X-ray computed tomography (XCT), supported by high-resolution synchrotron XCT, was used to benchmark the internal microstructure (e.g. porosity) as a function of four different build orientations in printed polyamide-12 (PA-12) parts. The initial performance of the parts after printing was characterized by tensile testing and dynamic mechanical analysis (DMA). Arrays of PA-12 parts in different build orientations were exposed to steam (under pressure) and air across multiple temperature and time points for the purposes of accelerated aging through oxidative and hydrolytic breakdown. Exposing parts to steam dramatically altered the internal microstructure and functional properties such as the glass transition temperature, tensile properties, and damping behavior. Notably, post-aging XCT revealed large microstructural changes after only 40 h of steam treatment relative to the as-printed specimens. Furthermore, pore reorganization and changes in crystallinity occurred regardless of whether the steam temperature was aggressive enough to induce a significant loss in mechanical properties. The build orientation dependence on the aging rate was minimal with the relative trend in performance persisting across most metrics among the different orientations even after aging.
Association of ANRIL Polymorphism With Overall Survival in Adult Patients With Hematologic Malignancies After Allogeneic Hematopoietic Stem Cell Transplantation.

Background/aim Genetic variations of the non-coding RNA gene, ANRIL, have been associated with human diseases including cancer, type-2 diabetes, and atherosclerosis. In the present study, we investigated the potential associations of select ANRIL single nucleotide polymorphisms (SNPs) with overall survival and other clinical outcomes in adult patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Patients and methods Genomic DNA was extracted from whole blood samples from 103 adult patients with hematologic malignancies who had received allo-HSCT followed by oral tacrolimus therapy. The genotypes of four select ANRIL SNPs, rs564398, rs1063192, rs2151280, and rs2157719 were determined using qRT-PCR-based genotyping assays. Results rs2151280 (C->T) in ANRIL was associated with worse overall survival in these patients (CT/CC vs. TT). Contrarily, rs2151280 and the other select ANRIL SNPs were not associated with death at Day-100 after transplantation, the incidence of graft-versus-host disease (GVHD), acute kidney injury (AKI), and neurotoxicity in the study cohort. Conclusion rs2151280 represents a potential prognostic biomarker for overall survival in adult patients with hematologic malignancies after allo-HSCT.
Exploring sociodemographic predictors of parents' perceptions about their children's autism and their families' adjustment.

Abstract Background Diagnostic and treatment disparities exist among sociodemographically diverse families with autism spectrum disorder (ASD). These disparities may be partially explained by the lack of information researchers and providers have regarding the unique experiences of diverse populations. Aims This study aimed to explore sociodemographic predictors of parents’ perceptions about their children’s ASD and families’ adjustment. Methods Hierarchical linear regression analyses were conducted to explore whether sociodemographic factors predicted aspects of parent’s perceptions and family adjustment among 363 parents of children and adolescents with ASD. Results Parents’ race/ethnicity, education level, and annual household income predicted their beliefs that they or treatment could be helpful in controlling their children’s ASD symptoms; their understanding of ASD; their experiences of emotional distress; their involvement in resources of support; and their families’ ability to manage stress. Conclusion Our results demonstrate the importance of considering the complexity of families’ demographic characteristics when working to support families with ASD. Parents’ unique characteristics and experiences influence their perceptions about their children’s ASD diagnosis and their families’ ability to adjust to life raising children with ASD. Research extending this work is a critical step in dismantling ASD diagnostic and treatment disparities.
Labeling Hacker Exploits for Proactive Cyber Threat Intelligence: A Deep Transfer Learning Approach

With the rapid development of new technologies, vulnerabilities are at an all-time high. Companies are investing in developing Cyber Threat Intelligence (CTI) to counteract these new vulnerabilities. However, this CTI is generally reactive based on internal data. Hacker forums can provide proactive CTI value through automated analysis of new trends and exploits. One way to identify exploits is by analyzing the source code that is posted on these forums. These source code snippets are often noisy and unlabeled, making standard data labeling techniques ineffective. This study aims to design a novel framework for the automated collection and categorization of hacker forum exploit source code. We propose a deep transfer learning framework, the Deep Transfer Learning for Exploit Labeling (DTL-EL). DTL-EL leverages the learned representation from professional labeled exploits to better generalize to hacker forum exploits. This model classifies the collected hacker forum exploits into eight predefined categories for proactive and timely CTI. The results of this study indicate that DTL-EL outperforms other prominent models in hacker forum literature.
Role of the Advanced Practice Provider in a Pediatric Dialysis Program

Many pediatric nephrology practices are recognizing the value that the advanced practice provider (APP) brings to their healthcare team. In this chapter you will better understand the preparation and training of APPs and how they can be utilized as an integral team member in both acute and chronic dialysis settings, facilitating care coordination, leading quality improvement initiatives, and ultimately improving both short- and long-term outcomes in this unique population. The APP is often the first-line healthcare provider, directing initial recommendations for acute dialysis complications, managing chronic dialysis care, and providing health-literate education to patients and families. This unique role empowers the APP to partner with physicians and practice to his or her full scope, functioning as an efficient and effective member of the healthcare team and providing optimal care for the pediatric dialysis patient.
Constraints on Gluon Distribution Functions in the Nucleon and Nucleus from Open Charm Hadron Production at the Electron-Ion Collider

Author(s): Kelsey, M; Cruz-Torres, R; Dong, X; Ji, Y; Radhakrishnan, S; Sichtermann, E | Abstract: The Electron-Ion Collider (EIC) at Brookhaven National Laboratory will be a precision quantum chromodynamics machine that will enable a vast physics program with electron+proton/ion collisions across a broad center-of-mass range. Measurements of hard probes such as heavy flavor in deep inelastic scatterings will be an essential component to the EIC physics program and are one of the detector RaD driving aspects. In this paper we study the projected statistical precision of open charm hadron production through exclusive hadronic channel reconstruction with a silicon detector concept currently being developed using a pythia-based simulation. We further study the impact of possible intrinsic charm in the proton on projected data, and estimate the constraint on the nuclear gluon parton distribution function (PDF) from the charm structure functions F2cc¯ in e+Au collisions using a Bayesian PDF reweighting technique. Our studies show the EIC will be capable of delivering an unprecedented measurement of charm hadron production across a broad kinematic region and will provide strong constraints to both intrinsic charm and nuclear gluon PDFs.