cssi/SciSciGPT-SciSciNet huggingface dataset:
Effect of furnace annealing on the ferroelectricity of Hf0.5 Zr0.5O2 thin films

Abstract The effect of furnace annealing on the ferroelectricity and crystal phase of Hf0.5ZrO2 (HZO) ultrathin films is studied as a function of film thickness. HZO films are deposited using atomic layer deposition (ALD) in a Ge-HZO-TiN stack with Pt as the top contact electrode. Furnace annealing is carried out after crystallizing the films with rapid thermal annealing in the presence of a TiN capping electrode. While furnace annealing did not have much impact on the 108 ALD cycles (~11 nm) film, it enhanced the ferroelectricity of the 44 ALD cycles film (~4.5 nm). Positive-up-negative-down tests provide evidence of ferroelectricity in the 40 ALD cycles (~4 nm) furnace annealed film after cycling the film at higher fields. Grazing incidence X-ray diffraction shows that the non-centrosymmetric orthorhombic phase responsible for ferroelectricity increased after furnace annealing in thinner films, but little change occurred in the 108 ALD cycles film that was rich in orthorhombic phase prior to furnace annealing. An analysis of the HZO films with a tapping mode atomic force microscope shows grain growth in the 44, and 40 ALD cycles films after furnace annealing.
Prescription opioids, alcohol and fatal motor vehicle crashes: a population-based case-control study

The prevalence of prescription opioid use among drivers has increased markedly in the past two decades. The purpose of this study is to assess the associations of prescription opioid use and alcohol use with the risk of fatal crash involvement in US drivers. We performed a population-based case-control study using toxicological testing data from two national data systems. Cases (n = 3606) were drivers involved in fatal motor vehicle crashes selected from the Fatality Analysis Reporting System and controls (n = 15,600) were drivers participating in the 2007 and 2013 National Roadside Surveys of Alcohol and Drug Use by Drivers. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) of fatal crash involvement associated with prescription opioid use with and without the presence of alcohol. Overall, cases were significantly more likely than controls to test positive for prescription opioids (5.0% vs. 3.7%, p < 0.001), alcohol (56.2% vs. 7.1%, p < 0.0001), and both substances (2.2% vs. 0.2%, p < 0.001). Relative to drivers testing negative for prescription opioids and alcohol, the adjusted ORs of fatal crash involvement were 1.72 (95% CI: 1.37, 2.17) for those testing positive for prescription opioids and negative for alcohol, 17.92 (95% CI: 16.19, 19.84) for those testing positive for alcohol and negative for prescription opioids, and 21.89 (95% CI: 14.38, 33.32) for those testing positive for both substances. The interaction effect on fatal crash risk of prescription opioid use and alcohol use was not statistically significant on either additive or multiplicative scale. Prescription opioid use is associated with a significantly increased risk of fatal crash involvement independently of alcohol use. Concurrent use of prescription opioids and alcohol is associated with a 21-fold increased risk of fatal crash involvement.
Recent Results from Beautyfull CESR

At present (8/81) the Cornell Electron Storage Ring (CESR) has the good fortune of being the world’s best source of b quarks.
siRNA Targeting and Treatment of Gastrointestinal Diseases

RNA interference via small interfering RNA (siRNA) offers opportunities to precisely target genes that contribute to gastrointestinal (GI) pathologies, such as inflammatory bowel disease, celiac, and esophageal scarring. Delivering the siRNA to the GI tract proves challenging as the harsh environment of the intestines degrades the siRNA before it can reach its target or blocks its entry into its site of action in the cytoplasm. Additionally, the GI tract is large and disease is often localized to a specific site. This review discusses polymer and lipid-based delivery systems for protection and targeting of siRNA therapies to the GI tract to treat local disease.
La construcción del umbral urbano

El ensayo aborda la relacion entre arquitectura y ciudad en la obra de Le Corbusier, analizando un ejemplo emblematico realizado en la decada de 1930: el Immeuble Clarte en Ginebra. El edificio colectivo es una oportunidad, por un lado, para la experimentacion tecnologica (con la aplicacion de la malla estructural en acero y ventanales continuos), y por el otro, para la aplicacion concreta de sus reflexiones sobre los tipos edilicios para la ciudad contemporanea, a partir de la critica a la rue corridor. El Clarte define claramente el tema del umbral urbano, como un lugar de confrontacion entre la casa y la ciudad: en este edificio, que mantiene unidos los principios arquitectonicos y compositivos del redent y del immeuble villa, la entrada-puerta y la fachada-ventana son de hecho interiores arquitectonicos y urbanos al mismo tiempo, y ocasion para construir, a traves de la arquitectura, ese lugar de la mediacion (el umbral) entre lo publico y lo privado, entre el edificio y la calle de la ciudad de Le Corbusier.
Organic Chemistry, Life, the Universe and Everything (OCLUE): A Transformed Organic Chemistry Curriculum

The fundamental structure of a typical mainstream two-semester organic chemistry course, populated mostly by life science majors and taught at universities throughout the United States, has changed...
Primate somatosensory cortical neurons are entrained to both spontaneous and peripherally evoked spindle oscillations.

Brief sensory stimuli evoke 10-Hz oscillations in thalamocortical neuronal activity and in perceptual thresholds. The mechanisms underlying this evoked rhythm are not well understood but are though...
BET proteins: Investigating BRDT as a potential target for male contraception

Abstract While many contraception options are available for women, birth control methods for men are limited to condoms and vasectomy. Past research into male contraceptives has focused on hormonal options but the associated side effects have thus far precluded this method from reaching the market. Non-hormonal male contraceptives and vas occlusion have also been explored, but to date no method has progressed past clinical testing. Recent interest in epigenetic research has unveiled a new potential non-hormonal male contraceptive target: the testis-specific bromodomain BRDT. Potent inhibitors for bromodomain-containing proteins are described in the literature, but a BRDT-specific compound has yet to be designed, prepared and tested. The high similarity between bromodomain proteins of the BET family makes development of selective and specific inhibitors both difficult and necessary. Selective inhibition of BRDT by a small molecule is an exciting new target in the search for a new non-hormonal male contraceptive.
Heat capacity peak at the quantum critical point of the transverse Ising magnet CoNb2O6

The archetypal transverse Ising magnet CoNb2O6 possesses a set of collective spin modes near its quantum critical point. Here, the authors use heat capacity measurements to evidence the existence of Fermionic gapless spin excitations at the critical point.
Difference in Internal and External Workloads between Non-Injured and Injured Groups in Collegiate Female Soccer Players

Background: Effects of internal and external workloads (IL, EL) on lower limb soft-tissue injuries (LLSTI) risk in male soccer players has been described, the relationships remain unclear in collegiate female (soccer players. Objective: The purpose was to examine the mean difference in IL and EL in LLSTI between non-injured and injured groups (N-IG and IG). Method: 20 collegiate female soccer players (age: 19.2±1.2years; height: 168.2±7.3cm; body mass: 41.0±17.9kg) were included for 14 week competitive season. IL included average heart rate (Avg-HR) and high heart rate zone. EL included total distance, average speed (Avg-Spd), and high-speed running distance. Injuries were counted if (a) they were LLSTI and muscular/ligamentous strains or tears and tendon problems, and (b) the players missed more than one match or training session. Acute (7-day simple average) and chronic (21-day simple average) IL and EL were calculated in the IG while the mean of acute (7-day) and chronic (21-day) IL and EL were computed in the NIG. Acute Chronic Workload Ratio (ACWR) was calculated as the ratio of acute and chronic IL and EL. Results: Seven LLSTI occurred over 14 weeks. The acute Avg-HR and ACWR of Avg-Spd were significantly higher in the IG than the N-IG (p=0.001 and 0.024). IL and EL in the IG were placed below or above the mean of the N-IG. Conclusion: LLSTI might occur at high and low workloads in collegiate female soccer players. This may support the use of micro-technology to monitor workload based on individual player’s threshold to reduce LLSTI.
Comprehensive Optimization of the Tripolar Concentric Ring Electrode with Respect to the Accuracy of Laplacian Estimation Based on the Finite Dimensions Model of the Electrode

Optimization performed in this study is based on the finite dimensions model of the concentric ring electrode as opposed to the negligible dimensions model widely used in the past. This makes the optimization problem comprehensive since all of the electrode parameters, including, for the first time, the radius of the central disc and individual widths of concentric rings, are optimized simultaneously. The optimization criterion used is maximizing the accuracy of the surface Laplacian estimation since the ability to estimate the Laplacian at each electrode constitutes the primary biomedical significance of concentric ring electrodes. Even though the obtained results and derived principles defining optimal electrode configurations are illustrated on tripolar (two concentric rings) electrodes, they were also confirmed for quadripolar (three rings) and pentapolar (four rings) electrodes and are likely to continue to hold for any higher number of concentric rings. For tripolar concentric ring electrodes, the optimal configuration was compared to previously proposed, linearly increasing inter-ring distances and constant inter-ring distances in configurations of the same size and based on the same finite dimensions model of the electrode. The obtained results suggest that previously proposed configurations correspond to almost two-fold and more than three-fold increases in Laplacian estimation error, respectively, compared to the optimal configuration proposed in this study.
A phase II, open-label pilot study evaluating the safety and activity of liposomal irinotecan (Nal-IRI) in combination with 5-FU and oxaliplatin (NALIRIFOX) in preoperative treatment of pancreatic adenocarcinoma (NEO-Nal-IRI Study).

TPS446Background: Neoadjuvant treatment for potentially curable pancreatic cancer (PDAC) is increasing in acceptability, but a standard regimen has yet to be established. Multiple studies have demo...
Persistent hypercoagulable state in COVID-19: A case series of COVID-19 associated pulmonary embolism

Coronavirus disease 2019 (COVID-19) has swept through the world with millions of cases and hundreds of thousands of deaths. COVID-19-associated coagulopathy has been recognized as the major cause of morbidity and mortality. To the best of our knowledge, a majority of the cases of coagulopathy have been reported in patients with moderate-to-severe COVID-19 and limited to observations during the recovery/postcytokine storm state. Herein, we report a case series of two patients with COVID-19 who developed pulmonary embolism in the late phase of the disease. This raised the hypothesis that the risk of hypercoagulability in patients with COVID-19 can persist until the recovery phase, which would warrant a follow-up with D-dimer and fibrinogen trending, as well as postdischarge thromboprophylaxis for at least 2 weeks during the recovery phase.
CheckSoft : A Scalable Event-Driven Software Architecture for Keeping Track of People and Things in People-Centric Spaces.

We present CheckSoft, a scalable event-driven software architecture for keeping track of people-object interactions in people-centric applications such as airport checkpoint security areas, automated retail stores, smart libraries, and so on. The architecture works off the video data generated in real time by a network of surveillance cameras. Although there are many different aspects to automating these applications, the most difficult part of the overall problem is keeping track of the interactions between the people and the objects. CheckSoft uses finite-state-machine (FSM) based logic for keeping track of such interactions which allows the system to quickly reject any false detections of the interactions by the video cameras. CheckSoft is easily scalable since the architecture is based on multi-processing in which a separate process is assigned to each human and to each "storage container" for the objects. A storage container may be a shelf on which the objects are displayed or a bin in which the objects are stored, depending on the specific application in which CheckSoft is deployed.
Personalized mathematical oncology: Challenges and opportunities

An outstanding challenge in the clinical care of cancer is moving from a one-size-fits-all approach that relies on population-level statistics towards personalized therapeutic design. Mathematical modeling is a powerful tool in treatment personalization, as it allows for the incorporation of patient-specific data so that treatment can be tailor-designed to the individual. In this work, we employ two fitting methodologies to personalize treatment in a mathematical model of murine cancer immunotherapy. Unexpectedly, we found that the predicted personalized treatment response is sensitive to the fitting methodology utilized. This raises concerns about the ability of mathematical models, even relatively simple ones, to make reliable predictions about individual treatment response. Our analyses shed light onto why it can be challenging to make personalized treatment recommendations from a model, but also suggest ways we can increase our confidence in personalized mathematical predictions. Author summaryAs we enter the era of healthcare where personalized medicine becomes a more common approach to treating cancer patients, harnessing the power of mathematical models will only become more essential. Using a preclinical dataset on cancer immunotherapy, we explore the challenges and limitations that arise when trying to move from a one-size-fits-all approach to treatment design towards personalized therapeutic design. These challenges lead to actionable suggestions on how to ascertain when we have enough data to personalize treatment, or how to determine when we can have confidence that an optimal-for-the-average prediction will have a comparable impact on an individual. We also show how mathematical modeling can suggest what data is needed to increased confidence in personalized predictions.
networkindustries.gov.reg

This essay is part of a Symposium entitled "American Regulatory Policy: Have We Found A Third Way?" The paper looks at the changes in the regulation of what were once called public utilities and are now called network industries. Traditional regulation is described and compared with the current form and structure of the regulation of these industries. The paper makes the argument that, even though deregulation is occurring consistent with Third Way thinking, it is occurring not only because of changes in world global economic views. Rather, it is changing because of what traditional regulation has accomplished. Traditional regulation constructed the infrastructure for the country and now service is nearly universally available. The traditional form of regulation should now give way and be "renegotiated." This is not to say that government regulation of network industries should be abandoned, however. In fact, severe problems remain including stranded costs, open access, and competition between incumbents and entrants. Because of these remaining problems, government regulation will continue and, ironically, regulators may take more of an active monitoring role on the competitiveness of various industries. The future of regulation depends upon how competitive markets can be and how well consumers are served during the current regulatory generation.
RWset: attacking path explosion in constraint-based test generation

Recent work has used variations of symbolic execution to automatically generate high-coverage test inputs [3, 4, 7, 8, 14]. Such tools have demonstrated their ability to find very subtle errors. However, one challenge they all face is how to effectively handle the exponential number of paths in checked code. This paper presents a new technique for reducing the number of traversed code paths by discarding those that must have side-effects identical to some previously explored path. Our results on a mix of open source applications and device drivers show that this (sound) optimization reduces the numbers of paths traversed by several orders of magnitude, often achieving program coverage far out of reach for a standard constraint-based execution system.
Examining differential treatment effects for depression in racial and ethnic minority women: a qualitative systematic review.

OBJECTIVE: To examine effectiveness of depression treatment in racial and ethnic minority women. REVIEW METHODS: Inclusion criteria: 1) the study examined treatment of depression among racial and ethnic minority women age > 17, 2) data analysis was separated by race and ethnicity, and 3) the study was conducted in the United States. Interventions considered were: psychotropic medications, psychotherapy (including cognitive-behavioral, interpersonal therapy and any type of psychotherapy adapted for minority populations) and any type of psychotherapy combined with case management or a religious focus. Individual and group psychotherapy were eligible. Each study was critically reviewed to identify treatment effectiveness specific to racial and ethnic minority women. RESULTS: Ten published studies met the inclusion criteria (racial and ethnic minority participants n = 2,136). Seven of these were randomized clinical trials, one was a retrospective cohort study, one was a case series, and the remaining one had an indeterminate study design. Participants' age ranged from 18-74 years, with a higher proportion > 40 years. Most were low income. Differences in treatment responses between African-American, Latino and white women were found. Adapted models of care, including quality improvement and collaborative care, were found to be more effective than usual care and community referral in treating depression. Although medication and psychotherapy were both effective in treating depression, low-income women generally needed case management to address other social issues. CONCLUSION: Adapted models that allow patients to select the treatment of their choice (medication or psychotherapy or a combination) while providing outreach and other supportive services (case management, childcare and transportation) appear to result in optimal clinical benefits.
What Equality Would Actually Look Like: Lessons from Anarchist Spain on Equality, Temporality and the Art of the Possible

This paper looks at the practice of political equality in the 1920s and 1930s in the anarchist parts of Spain. I argue that political equality is a very rare thing; although thinkers like Arendt extol the Greeks for their practice, I argue that anarchists in Spain came much closer to achieving a real and practicable form of political equality. By looking at archival materials (in this case mainly newspapers from the period in question) I examine the way that the Spanish anarchists thought about their own heroes, about questions of organization and about temporality and their sense of what was possible. These investigations seek to give us a sense of the actual practices and views of this period. In looking at these practices, I seek to form what Walter Benjamin would call a "constellation" with our own time. A constellation serves as a juxtaposition of temporalities that in this case serves to undermine the contemporary conviction that anarchism is impossible or utopian, that we have no choice but to accept "the fact of inequality."
Entering Teaching for and with Love: Visions of Pre-Service Urban Teachers.

Using a social justice orientation to teacher education and a sociocultural approach to learning, this exploratory study presents data from twenty pre-service urban teachers about their perceptions of and visions for teaching in urban schools. Findings reveal candidates‘ desires to care for and build relationships with urban youth as a foundation for their interests in teaching and also portray participants‘ visions of teaching as a way to promote positive social change in their communities. Findings are discussed in the context of future directions for urban teacher education.
The Stellar Initial Mass Function in Starburst Galaxies

Starburst galaxies are currently forming massive stars at prodigious rates. I discuss the star-formation histories and the shape of the initial mass function, with particular emphasis on the high — and on the low-mass end. The classical Salpeter IMF is consistent with constraints from observations of the most massive stars, irrespective of environmental properties. The situation at the low-mass end is less clear: direct star counts in nearby giant H II regions show stars down to ∼1 M⨀, whereas dynamical arguments in some starburst galaxies suggest a deficit of such stars.
The Effect of the January 10, 1997, Pressure Pulse on the Magnetosphere-Ionosphere Current System

On January 10, 1997, a strong pressure pulse, observed by the WIND spacecraft between 1030 and 1055 UT, hit the magnetosphere after about a one-half hour delay, causing the strengthening and widening of the auroral electrojet at all local times. The duration of the electrojet perturbation was the same as the duration of the solar wind pressure pulse. The pulse occurred during the well-studied January 10-11, 1997, magnetic storm and during strong geomagnetic activity. We study the effect of the pressure pulse on the ionospheric current using a global network of more than 100 ground magnetometers, images from the POLAR spacecraft, and solar wind measurements from the WIND and Geotail spacecraft. We find that the magnetospheric and ionospheric response is directly driven by the solar wind conditions and clearly related to the onset, duration and end of the pressure pulse. In addition, it appears that the enhancement of the Region 1 currents opposed the effect of the enhancement of the magnetopause current for locations near noon. These responses are not characteristics of a typical substorm.
QUANTITATIVE ANALYSIS OF LA CROSSE VIRUS TRANSCRIPTION AND REPLICATION IN CELL CULTURES AND MOSQUITOES

La Crosse (LAC) virus (family Bunyaviridae, genus Orthobunyavirus) small (S) segment negative-sense RNA genome (vRNA), positive-sense full-length RNA complement (vcRNA), and subgenomic mRNA were assayed in infected cell cultures and female Aedes (Ochlerotatus) triseriatus mosquito tissues using quantitative PCR (Q-PCR). During persistent infection of C6/36 (Aedes albopictus) and MAT (Aedes triseriatus) cultured cells and cytolytic infection of BHK-21 cultured cells, LAC vRNA was the most abundant RNA species, followed by mRNA and vcRNA. RNA copy numbers per cell were quantified and vRNA correlated to virus titer in cell culture medium. The Q-PCR assay proved more sensitive than reverse transcription (RT)-PCR and immunofluorescence assays (IFA) for detecting LAC virus infection of mosquitoes. After infection of female mosquitoes orally, quantities of LAC RNA increased in ovaries for 6 days, and as ovarian biosynthetic activity quiesced, LAC RNA quantities decreased then remained detectable at a low level. After a second, noninfectious blood meal, quantities of LAC RNA in ovaries increased significantly, quantitatively confirming correlation of LAC virus RNA synthesis with vector metabolic activity. Coregulation of viral replication and mosquito ovary metabolic activity may condition efficient transovarial transmission.
Ballot Manipulation and the "Menace of Negro Domination": Racial Threat and Felon Disenfranchisement in the United States, 1850-2002

Criminal offenders in the United States typically forfeit voting rights as a collateral consequence of their felony convictions. This article analyzes the origins and development of these state felon disenfranchisement provisions. Because these laws tend to dilute the voting strength of racial minorities, we build on theories of group threat to test whether racial threat influenced their passage. Many felon voting bans were passed in the late 1860s and 1870s, when implementation of the Fifteenth Amendment and its extension of voting rights to African‐Americans were ardently contested. We find that large nonwhite prison populations increase the odds of passing restrictive laws, and, further, that prison and state racial composition may be linked to the adoption of reenfranchisement reforms. These findings are important for understanding restrictions on the civil rights of citizens convicted of crime and, more generally, the role of racial conflict in American political development.
Transition from Intensive Tillage to No-Tillage and Organic Diversified Annual Cropping Systems

Transition to no-till (NT) and organic (ORG) farming systems may enhance sustainability. Our objectives were to compare transitional crop productivity and soil nutrient status among diversified NT and ORG cropping systems in Montana. Three NT systems were designed as 4-yr rotations, including a pulse (lentil [Lens culinaris Medik.] or pea [Pisum sativum L.]), an oilseed (canola [Brassica napus L.] or sunflower [Helianthus annuus L.]) and two cereal crops (corn [Zea mays L.], proso millet [Panicum miliaceum L.], or wheat [Triticum aestivum L.]). No-till continuous wheat was also included. The ORG system included a green manure (pea), wheat, lentil, and barley (Hordeum vulgare L.) and received no inputs. Winter wheat in the ORG system yielded equal or greater than in the NT systems, and had superior grain quality, even though 117 kg N ha -1 was applied to the NT winter wheat. After 4 yr, soil nitrate-N and Olsen-P were 41 and 14% lower in the ORG system, whereas potentially mineralizable N was 23% higher in the ORG system. After 4 yr, total economic net returns were equal between NT and ORG systems on a per-ha basis. Studying simultaneous transition to diversified NT and ORG cropping systems was instructive for increased sustainability.
Signals from blue cones in "red-green" opponent-colour ganglion cells of the macaque retina.

Abstract Many opponent-colour ganglion cells of the macaque retina overt input from green and red-sensitive cones but often appear to lack input from blue-sensitive cones under usual test conditions. Comparisons of field and test action spectra of the responses of a selected group of such “red-green” ganglion cells, located in the perifovea and lacking rod input, indicate the presence of blue-sensitive cone signals having a suppressive influence upon the more direct and opponent signals from green- and red-sensitive cones to a fraction of these neurones, which seems to take place at a level distal to that of the ganglion cell. No cell excitation of inhibition mediated by blue-sensitive cone signals could be observed on intense yellow-adapting lights desensitizing the other two cone types. These neurones are characterized by a sharp fall-off in their short-wavelength test sensitivity and by a secondary shoulder in their short-wavelength field sensitivity. In addition, when cell responses overtly mediated by input from green-sensitive cones are depressed by the geometry of the stimuli, the suppressive signals from blue-sensitive cones also result in a large displacement towards the short wavelengths of the test peak sensitivity of such responses. This displacement can be described with acceptable accuracy by a two-stage model based on subtractive interactions between A1-photopigments with λmax at 445, 535 and 570 nm, which is qualitatively consistent with other spectral properties of these ganglion cells.
Surveillance for health behaviors of American Indians and Alaska Natives—Findings from the behavioral risk factor surveillance system, 2000–2006

BACKGROUND. The authors compared estimates for cancer risk factors, use of cancer screening tests, health status indicators, and access to care for American Indians and Alaska Natives (AI/ANs) and non-Hispanic whites (NHWs) in the US and for AI/ANs in 6 Indian Health Service regions. METHODS. Behavioral Risk Factor Surveillance System data were aggregated from the years 2000 through 2006 and were used to calculate weighted prevalence estimates by gender for key variables except demographic variables. RESULTS. Compared with NHWs, AI/ANs had lower prevalence estimates for income, educational attainment, insurance coverage, and access to personal healthcare providers. AI/ANs in Alaska and NHWs had similar estimates for diabetes (approximately 6%); however, the prevalence was nearly twice as high among AI/ANs in the other regions. The prevalence of obesity was higher for AI/ANs (29.6%) than for NHWs (20.9%). The prevalence of binge drinking was higher among AI/AN males (24.9%) than among AI/AN females (8.5%). Heavy drinking was more prevalent among NHW females (5.3%) than among AI/AN females (3.5%). AI/ANs were more likely to be current smokers (31.1%) than NHWs (22.8%). The prevalence of AI/ANs who never smoked ranged from 31.5% in Alaska to 56.9% in the Southwest. In 5 of the 6 regions, AI/AN females had lower prevalence estimates of both Papanicolaou and mammography testing than NHW females. The use of colorectal cancer screening tests was more common among NHWs (53.8%) than among AI/ANs (44%). CONCLUSIONS. Although cancer health disparities persist among AI/ANs, the current analysis indicated that variation in the prevalence of their chronic disease risk factors may be obscured when national data are not examined by smaller geographic areas such as regions. Cancer 2008;113(5 suppl):1131–41. Published 2008 by the American Cancer Society.
Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade

Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected ~8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A, localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.
Immunocytochemical localization of immunoglobulins in the rat brain: Relationship to the blood-brain barrier

The central nervous system has been traditionally regarded as an immunologically privileged area. This feature has been in part attributed to the blood-brain barrier, which provides a restrictive interface to circulating immunoglobulins (IgG). Recent kinetic studies suggest that the barrier to immune proteins is not absolute, but rather may be regulated by a specific transfer mechanism. In this study, we confirm the presence of IgG in the central nervous system by immunocytochemistry and demonstrate a close anatomical relationship between the distribution of this protein and the blood-brain barrier. IgG was immunolocalized in the normal rat brain by using monoclonal and polyclonal antibodies to IgG and its subclasses. On the basis of an initial evaluation, the most appropriate antibodies and dilutions were selected for subsequent analyses. In the first study, IgG and albumin were immunolocalized in adjacent sections. In the second study, horseradish peroxidase (HRP) was given intravenously prior to sacrifice, in order to examine artifacts related to perfusion fixation. The distribution of HRP and IgG was then examined in adjacent sections. In the third study, IgG was immunolocalized in sections of brain after mild traumatic head injury. A monoclonal antibody to IgG2a and a polyclonal antibody to IgG were selected on the basis of specificity and consistent, mutual localization. Distinct, patchy, perivascular staining, infrequently associated with labeled neurons, was noted throughout the brain. Electron microscopy confirmed the perivascular localization; IgG was localized along the basal lamina of microvasculature and within the adjacent parenchyma. Albumin and HRP did not exhibit a similar pattern of perivascular immunostaining. After head injury, prominent immunostaining for IgG was observed in the injured hemisphere. In summary, these data indicate that the normal rat brain contains IgG, which dramatically increases after head injury. The distinct perivascular distribution in the normal brain suggests local microvascular permeability. This permeability is selective for IgG, since albumin does not share a similar perivascular localization. The neuronal staining which is closely associated with perivascular label may reflect one intracellular route for extravasated IgG.
A study of the difference between nominal and actual hand forces in two-handed sagittal plane whole-body exertions.

Given a task posture, changes in hand force magnitude and direction with regard to joint locations result in variations in joint loads. Previous work has quantified considerable vertical force components during push/pull exertions. The objective of this work was to quantify and statistically model actual hand forces in two-hand, standing exertions relative to the required nominal horizontal and vertical hand forces for a population of widely varying stature and strength. A total of 19 participants exerted force on a fixed handle while receiving visual feedback on the magnitude of force exerted in the required horizontal or vertical direction. A set of regression equations with adjusted R2 values ranging from 0.20 to 0.66 were developed to define actual hand force vectors by predicting off-axis forces from the required hand force magnitude. Off-axis forces significantly increase the overall magnitude of force exerted in two-hand push/pull and up/down standing force exertions. Statement of Relevance:This st...
First Report of Fusarium Wilt of Cilantro Caused by Fusarium oxysporum in California

Cilantro, or coriander (Coriandrum sativum), is a leafy vegetable in the Apiaceae and is grown commercially in California primarily for use as a fresh herb. During 2002 and 2003 in coastal California (Santa Barbara County), commercial cilantro fields showed symptoms of a wilt disease. Affected plants grew poorly and were stunted. Lower foliage turned yellow with reddish tinges, and plants wilted during warmer times of the day. The main stem, crown, and taproot exhibited vascular discoloration that was reddish to light brown. As disease progressed, plants eventually died. For both years, the disease distribution was limited to isolated small patches (each patch measuring less than 1 m2 in area). A fungus was consistently isolated from symptomatic vascular tissue in crowns and taproots. On the basis of colony and conidial morphology, the isolates were identified as Fusarium oxysporum (2). No other fungi or bacteria were recovered from these plants. To test pathogenicity, suspensions containing 1 × 106 conidia/ml were prepared for five isolates. The roots of 30-day-old cilantro plants of four cultivars (30 plants each of Festival, Leisure, Santo, and LSO 14) were clipped and then soaked in the suspensions for 20 min. The roots of 30 plants of each cultivar were soaked in water as a control. Plants were repotted into new redwood bark + peat moss rooting medium and maintained in a greenhouse setting at 24 to 26°C. After 1 month, 95% or more of the inoculated plants showed yellowing and vascular discoloration symptoms similar to those seen in the field. F. oxysporum was reisolated from all inoculated plants. The four cilantro cultivars did not show differences in disease severity. Control plants showed no symptoms, and the fungus was not recovered from these plants. The experiment was repeated and the results were the same. Experiments also were conducted to determine if cilantro isolates could cause disease in celery (Apium graveolens var. dulce). Celery transplants and cilantro seedlings were prepared and inoculated as described above. However, after 2 months, celery plants did not show any disease symptoms, while the cilantro developed wilt symptoms and eventually died. A Fusarium wilt disease has been reported on coriander in Argentina and India where the pathogen was named F. oxysporum f. sp. coriandrii (1,3). To our knowledge, this is the first report of Fusarium wilt of cilantro in California. References: (1) M. Madia et al. Fitopatologia 34:155, 1999. (2) P. E. Nelson et al. Fusarium species: An Illustrated Manual for Identification. Pennsylvania State University Press, University Park, 1983. (3) U. S. Srivastava. Indian Phytopathol. 22:406, 1969.
Mechanics of dual-mode dilative failure in subaqueous sediment deposits

Abstract We introduce dual-mode dilative failure with flume experiments. Dual-mode dilative failure combines slow and steady release of sediments by breaching with periodic sliding, which rapidly releases an internally coherent wedge of sediments. It occurs in dilative sandy deposits. This periodic slope failure results from cyclic evolution of the excess pore pressure in the deposit. Sliding generates large, transient, negative excess pore pressure that strengthens the deposit and allows breaching to occur. During breaching, negative excess pore pressure dissipates, the deposit weakens, and ultimately sliding occurs once again. We show that the sliding frequency is proportional to the coefficient of consolidation. We find that thicker deposits are more susceptible to dual-mode dilative failure. Discovery of dual-mode dilative failure provides a new mechanism to consider when interpreting the sedimentary deposits linked to submarine slope failures.
Is the odour identification deficit in schizophrenia influenced by odour hedonics

INTRODUCTION. While smell identification deficits have been well documented in schizophrenia, less work has examined identification accuracy for pleasant and unpleasant odours. The current investigation examined odour identification performance for pleasant and unpleasant odours in a sample of inpatients with schizophrenia and nonpsychiatric community controls. METHOD. The Brief Smell Identification Test was used to investigate accuracy in the identification of pleasant and unpleasant odours in 23 schizophrenia inpatients and 21 nonpsychiatric controls. RESULTS. Results revealed that schizophrenia patients showed reduced accuracy on pleasant odours, but intact performance for unpleasant odours. CONCLUSIONS. Results provide preliminary support for a specific deficit in identifying pleasant odours in patients with schizophrenia. Future studies separating odours by valence categories are warranted.
Dynamics of rice prices and agricultural wages in the Philippines

Rice trade liberalization in the Philippines should decrease domestic rice prices impacting both agricultural wages and the welfare of agricultural wage earners. This study examines the short-run and long-run relationship between rice prices and agricultural wages in the Philippines using a neoclassical wage determination model. Three empirical frameworks are used—a cointegration/error correction framework, which assumes nonstationary variables in long-run equilibrium, a first difference model that assumes nonstationary variables but no long-run equilibrium, and an OLS framework that assumes the model variables are stationary. Conclusions are reasonably robust across the three empirical frameworks with wages adjusting positively to rice price changes with a short-run elasticity of 0.29 to 0.57, and a long-run elasticity of 0.70 to 1.0 in preferred models. An analysis of welfare implications suggests that although households that are heavily reliant on agricultural wages for income will be adversely affected by rice price decreases, other households will benefit.
Rapid Formation of Left Atrial Appendage Thrombus After Unsuccessful Cardioversion of Atrial Fibrillation

The acute effect of failed attempts of cardioversion on left atrial (LA) and left atrial appendage (LAA) functions are generally considered benign and no adverse effects have been reported. We report on a subject who had rapid formation of a fresh, mobile thrombus in the LAA despite unsuccessful cardioversion and therapeutic anticoagulation.
OASYS: a framework for analog circuit synthesis

A hierarchically structured framework for analog circuit synthesis is described. This hierarchical structure has two important features: it decomposes the design task into a sequence of smaller tasks with uniform structure, and it simplifies the reuse of design knowledge. Mechanisms are described that select from among alternate design styles and translate performance specifications from one level in the hierarchy to the next lower, more concrete level. A prototype implementation, OASYS, synthesizes sized transistor schematics for CMOS operational amplifiers from performance specifications and process parameters. Measurements from detailed circuit simulation and from actual fabricated analog ICs based on OASYS-synthesized designs demonstrate that OASYS is capable of synthesizing functional circuits. >
A fixed-mesh method for incompressible flow-structure systems with finite solid deformations

A fixed-mesh algorithm is proposed for simulating flow-structure interactions such as those occurring in biological systems, in which both the fluid and solid are incompressible and the solid deformations are large. Several of the well-known difficulties in simulating such flow-structure interactions are avoided by formulating a single set of equations of motion on a fixed Eulerian mesh. The solid's deformation is tracked to compute elastic stresses by an overlapping Lagrangian mesh. In this way, the flow-structure interaction is formulated as a distributed body force and singular surface force acting on an otherwise purely fluid system. These forces, which depend on the solid elastic stress distribution, are computed on the Lagrangian mesh by a standard finite-element method and then transferred to the fixed Eulerian mesh, where the joint momentum and continuity equations are solved by a finite-difference method. The constitutive model for the solid can be quite general. For the force transfer, standard immersed-boundary and immersed-interface methods can be used and are demonstrated. We have also developed and demonstrated a new projection method that unifies the transfer of the surface and body forces in a way that exactly conserves momentum; the interface is still effectively sharp for this approach. The spatial convergence of the method is observed to be between first- and second-order, as in most immersed-boundary methods for membrane flows. The algorithm is demonstrated by the simulations of an advected elastic disk, a flexible leaflet in an oscillating flow, and a model of a swimming jellyfish.
The role of the sexual organs in the generation of postembryonic neurons in the leech Hirudo medicinalis

In adult Hirudo medicinalis, the segmental ganglia (SG) of the fifth and sixth body segments contain a few hundred more cells than the other segmental ganglia of the body (Macagno, 1980). These ganglia innervate the sex organs and are known as the sex SG. As shown here, these cells are stained by neuron-specific antibodies. Cell counts at several developmental stages reveal that the extra cells are added exclusively to the sex SG, and that this addition occurs gradually and almost entirely postembryonically (embryogenesis ends at 30 days of development). Hence, we refer to them as PE cells. Until 16 days of development, deleting the male genitalia or disconnecting them from the sex ganglia results in a complete absence of the PE cells. From 16 days onward, the generation of the PE cells is independent of the male genitalia. No PE cells appear in non-sex SG that innervate male genitalia transplanted to ectopic locations at 10 days or later, indicating that as early as about 10 days of development sex SG are different from other SG in their ability to acquire PE cells. These data suggest that the PE cells are generated within the sex SG, in a process that is triggered by an interaction with the male genitalia and mediated through the innervation of the organs by these ganglia.
The Role of Budget Stabilization Funds in Smoothing Government Expenditures over the Business Cycle

The economic downturn that began in 2001 resulted in sizable budget shortfalls and arguably the worst fiscal conditions for state governments in decades. The use of savings to stabilize cyclical fluctuations in the budget has been institutionalized in most states in the form of budget stabilization funds. In this article, the authors explore how state expenditure volatility is affected by the existence, size, and structure of stabilization funds using multiple measures of expenditure cyclicality over the period from 1969 to 1999. The results indicate that while most states have not witnessed a reduction in expenditure volatility over the business cycle, states with rule-bound stabilization funds experience significantly less expenditure volatility from utilizing a budget stabilization fund. In fact, the authors find that state expenditures are approximately 20 percent less volatile following the adoption of a rule-bound budget stabilization fund.
Turbulent flow between counter-rotating concentric cylinders : a direct numerical simulation study

We report three-dimensional direct numerical simulations of the turbulent flow between counter-rotating concentric cylinders with a radius ratio 0.5. The inner- and outer-cylinder Reynolds numbers have the same magnitude, which ranges from 500 to 4000 in the simulations. We show that with the increase of Reynolds number, the prevailing structures in the flow are azimuthal vortices with scales much smaller than the cylinder gap. At high Reynolds numbers, while the instantaneous small-scale vortices permeate the entire domain, the large-scale Taylor vortex motions manifested by the time-averaged field do not penetrate a layer of fluid near the outer cylinder. Comparisons between the standard Taylor–Couette system (rotating inner cylinder, fixed outer cylinder) and the counter-rotating system demonstrate the profound effects of the Coriolis force on the mean flow and other statistical quantities. The dynamical and statistical features of the flow have been investigated in detail.