cssi/SciSciGPT-SciSciNet huggingface dataset:
School-aged Children’s Psychobiological Divergence as a Prospective Predictor of Health Risk Behaviors in Adolescence

Recent attachment research suggests that children with avoidant attachment often underreport their psychological distress compared to their physiologic indicators of distress (neuroendocrine reactivity, startle response, event-related potentials). This pattern of behavior (referred to as psychobiological divergence) may confer risk for suboptimal coping behaviors, including substance use, sexual risk-taking, and non-suicidal self-injury (NSSI), because individuals who are not aware of or cannot express their emotional needs may engage in maladaptive strategies to regulate their emotions. In the current pilot study (N = 45 youth), we investigate whether psychobiological divergence of neuroendocrine and self-reported reactivity in middle childhood prospectively predicts health risk behaviors (HRBs) in adolescence. The results revealed that divergence was significantly associated with adolescents’ substance use and non-suicidal self-injury (NSSI), but not with their sexual behavior. Among adolescents currently reporting low levels of attachment security, divergence was associated with greater self-reported NSSI. Our results provide initial evidence that psychobiological divergence confers risk for substance use and NSSI in combination with current relational distress. We discuss the implications of our findings for adolescent development and clinical risk.
Outcomes of surgery for infective endocarditis: a single-centre experience of 801 patients.

OBJECTIVES Infective endocarditis (IE) remains a life-threatening disease, despite the improvement in diagnostic and therapeutic measures. We reviewed our outcomes for all adults who underwent surgery for endocarditis at our centre. METHODS Between January 1995 and December 2013, 801 patients [586 men (73%)] underwent surgery for IE. Mean age was 60 ± 14.7 years. Native endocarditis (NE) was present in 372 patients (46%), and 379 (47%) patients had active IE. The mean follow-up period was 4.6 ± 4.75 years (maximum 20 years). RESULTS Single-valve endocarditis was present in 551 (69%) patients (392 aortic and 159 mitral). Multivalve involvement was present in 250 (31%) patients. Preoperative stroke was present in 149 (19%) patients, while 62 (8%) patients were on dialysis prior to surgery. Valve repair was possible in 122 (15%) patients, while 679 (85%) patients underwent valve replacement. Mechanical valves were used in 312 (39%) patients. Aortic homografts were used in 84 (10%) patients. Early mortality occurred in 64 (8%) patients. Overall survival at 5, 10 and 20 years was 68%, 45% and 8.4%, respectively. Postoperative stroke occurred in 16 (2%) patients, while 59 (7%) patients required new dialysis postoperatively. Multivariate analysis revealed active IE (P = 0.002), preoperative dialysis (P = 0.007), previous coronary artery bypass grafting (P = 0.001), root abscess (P = 0.006) and tricuspid valve or multivalve involvement (P = 0.002) to be predictors of early mortality. The need for dialysis (P < 0.001), previous coronary artery bypass grafting (P < 0.001) and mitral valve (P = 0.002) and tricuspid valve/multivalve involvement (P < 0.001) were significant predictors of late mortality. CONCLUSIONS Active IE is associated with high perioperative mortality especially with multivalve and aortic root involvement. Preoperative stroke has no impact on perioperative mortality. Long-term survival for those who survived the immediate postoperative period is satisfactory, and mechanical valves are associated with the best long-term survival.
Influence de la culture d’entreprise et des politiques de ressources humaines sur la stratégie Supply Chain Management (SCM)

Cet article presente la politique de ressources humaines et la culture d’une entreprise comme deux elements importants a considerer lors de l’elaboration d’une strategie supply chain. Il montre aussi qu’une entreprise doit considerer l’interaction entre sa politique ressources humaines (relation ou transaction), et sa strategie logistique (relation ou transaction). Ne pas atteindre de facon satisfaisante cette concordance strategique peut entrainer une reduction de l’efficacite de la chaine dans son ensemble.
Cannabis for Chronic Pain: Challenges and Considerations

The National Academies of Sciences, Engineering, and Medicine has found substantial evidence that cannabis (plant) is effective for the treatment of chronic pain in adults, and moderate evidence that oromucosal cannabinoids (extracts, especially nabiximols) improve short-term sleep disturbances in chronic pain. The paradoxical superiority of the cannabis plant over cannabinoid molecules represents a challenge for the medical community and the established processes that define modern pharmacy. The expanding and variable legalization of cannabis in multiple states nationwide represents an additional challenge for patients and the medical community because recreational and medicinal cannabis are irresponsibly overlapped. Cannabis designed for recreational use (containing high levels of active ingredients) is increasingly available to patients with chronic pain who do not find relief with current pharmacologic entities, which exposes patients to potential harm. This article analyzes the available scientific evidence to address controversial questions that the current state of cannabis poses for health care professionals and chronic pain patients and sets the basis for a more open discussion about the role of cannabis in modern medicine for pain management. A critical discussion on these points, the legal status of cannabis, and considerations for health care providers is presented.
EEG Patterns in Routine Polysomnography in Childhood and Risk of Epilepsy (P2.295)

Objective: Evaluate the frequency of abnormal EEG records during pediatric polysomnography (PSG) at a tertiary referral center and determine frequency with which these records may predict a future diagnosis of epilepsy over a 30-month period. Background: Polysomnography is an increasingly ordered in pediatric medicine. When an EEG abnormality occurs during PSG, there is confusion amongst practitioners about how to use this information, prompting additional diagnostic testing and specialist evaluations. Design/Methods: Retrospective review of all pediatric PSG reports from 2013 was performed (n = 2045). Demographics, medical history, and PSG and EEG reports were collected. Patients were evaluated for follow-up and future diagnosis of epilepsy over a 30-month period. Results: A total of 1969 studies (56.9% males) were included in analysis. The average age was 7.36+/−4.28 years. The number of patients with a history of seizures or epilepsy was 187 (9.5%). A total of 317 (16.1%, 59% males) studies had abnormal EEGs compared to age-appropriate norms; average age of these records was 6.68+/−3.92 years. From abnormal EEG records, 130 (41.0%) held a prior diagnosis of seizures or epilepsy. Of the 187 patients without a prior diagnosis of seizures or epilepsy and an abnormal EEG, the most common patterns encountered were slow or absent posterior dominant rhythm (32.1%) and isolated sharp waves (25.1%). Thirty-nine patients had follow-up diagnostic EEGs and 97 had clinic follow-up. Thirteen patients total in the 30-month window developed a new diagnosis of seizure or epilepsy. Each new diagnosis of epilepsy occurred in a high-risk patient (e.g. two with trisomy 18). Conclusions: Abnormal EEG recordings during routine pediatric PSGs without a suggestive clinical history of seizure is a poor prognostication tool for future diagnosis of epilepsy. The utility of diagnostic EEG to corroborate EEG findings during PSG does not appear to be supported without additional clinical context. Study Supported by: n/a Disclosure: Dr. Stowe has nothing to disclose. Dr. Glaze has nothing to disclose.
Leukoerythroblastosis in the adult.

12 is the presence of immature cells of the myeloid series and nucleated red cells in the circulating blood, with or without anemia. The purpose of this paper is to present a large series of adults with this finding, and in particular to analyze the frequency of various causes in order to determine the value of the abnormality as a diagnostic clue. This study was prompted by a series of recently reported cases which did not confirm the commonly held opinion that leukoerythroblastosis is most frequently seen in the adult with involvement of the marrow by a malignant neoplasm. 8
Modeling a Graph Viewer’s Effort in Recognizing Messages Conveyed by Grouped Bar Charts

Information graphics (bar charts, line graphs, etc.) in popular media generally have a high-level message that they are intended to convey. These messages are seldom repeated in the document’s text yet contribute to understanding the overall document. The relative perceptual effort required to recognize a particular message is a communicative signal that serves as a clue about whether that message is the one intended by the graph designer. This paper presents a model of relative effort by a viewer for recognizing different messages from grouped bar charts. The model is implemented within the ACT-R cognitive framework and has been validated by human subjects experiments. We also present a statistical analysis of the contribution of effort in recognizing the intended message of a grouped bar chart.
pH Homeostasis in Terrestrial Vertebrates; Ammonium Ion as a Proton Source

Homeostasis and functional regulation are among the most characteristic and essential features of organisms. Intracellular pH is especially critical, and organisms of all types have evolved elaborate and metabolically costly mechanisms for its stabilization. Of necessity, those mechanisms vary widely in order to be effective in types as diverse as bacteria and mammals, living in habitats that range from aqueous to xeric and from well-aerated to anoxic.
Clandestine Drug Manufacturing Laboratories

Clandestine, or illegal, drug manufacturing laboratories have been established by the criminal element for the purpose of supplying drugs of abuse to the illicit market. This article will review the significant role of forensic scientists in identifying and immobilizing clandestine laboratories. To accomplish this role, the forensic scientist must be familiar with the methods of synthesis for the drugs being produced in these laboratories. As an aide to forensic scientists, the article will examine the drugs being synthesized in clandestine laboratories, the methods of synthesis commonly being used by clandestine laboratory operators, and the methods of chemical analysis that describe significant components present in evidential material seized at these laboratories which enable the method of synthesis to be determined.
Astonishingly unethical behavior.

A student responds to an article in the March 2007 issue of Virtual Mentor regarding the television show House. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
The Expression of Neuronal Specificity in Tissue Culture

The earliest work with nerve tissue in culture was undertaken by experimental embryologists and was designed to address several pressing questions that could not be definitively studied in the developing embryo. Of this early work, the contribution of Harrison (1910) to the understanding of the mechanisms involved in axonal elongation and that of Weiss (reviewed in 1955) to the study of the mechanisms of axon guidance are particularly well known. More recently, the use of tissue culture made a further noteworthy contribution to neuroembryology when employed to demonstrate the humoral nature of the nerve growth factor of the mouse submandibular gland (Levi-Montalcini et al., 1954). Considering the substantial contributions made by these relatively few efforts, it is surprising that culture techniques did not find more frequent use in neuroembryological research.
Mixed methods examination of diverse patients’ experiences with precision oncology.

e22148Background: Tumor molecular profiling holds great promise for improving outcomes, however patients’ comprehension and decision processes have not been examined. Methods: Purposive sampling wa...
High Impedance Faults Location in the Distribution Networks using Adaptive Neuro-Fuzzy Inference System

The High Impedance Faults are the faults which are difficult to detect. In this paper, a generalized High Impedance Faults arc model is presented. The proposed model is based on anti-parallel diodes with non-linear resistance and DC source connected together. The location of this kind of fault is difficult because it does not cause strong currents. The Adaptive Neuro-Fuzzy Inference System will be used to localize this type of fault in a network at 24 nodes using a single-phase fault to ground. MATLAB software was used to do all the tests.
Inter-platform reproducibility of ultrasonic attenuation and backscatter coefficients in assessing NAFLD.

To assess inter-platform reproducibility of ultrasonic attenuation coefficient (AC) and backscatter coefficient (BSC) estimates in adults with known/suspected nonalcoholic fatty liver disease (NAFLD). This HIPAA-compliant prospective study was approved by an institutional review board; informed consent was obtained. Participants with known/suspected NAFLD were recruited and underwent same-day liver examinations with clinical ultrasound scanner platforms from two manufacturers. Each participant was scanned by the same trained sonographer who performed multiple data acquisitions in the right liver lobe using a lateral intercostal approach. Each data acquisition recorded a B-mode image and the underlying radio frequency (RF) data. AC and BSC were calculated using the reference phantom method. Inter-platform reproducibility was evaluated for AC and log-transformed BSC (logBSC = 10log10BSC) by intraclass correlation coefficient (ICC), Pearson’s correlation, Bland-Altman analysis with computation of limits of agreement (LOAs), and within-subject coefficient of variation (wCV; applicable to AC). Sixty-four participants were enrolled. Mean AC values measured using the two platforms were 0.90 ± 0.13 and 0.94 ± 0.15 dB/cm/MHz while mean logBSC values were − 30.6 ± 5.0 and − 27.9 ± 5.6 dB, respectively. Inter-platform ICC was 0.77 for AC and 0.70 for log-transformed BSC in terms of absolute agreement. Pearson’s correlation coefficient was 0.81 for AC and 0.80 for logBSC. Ninety-five percent LOAs were − 0.21 to 0.13 dB/cm/MHz for AC, and − 9.48 to 3.98 dB for logBSC. The wCV was 7% for AC. Hepatic AC and BSC are reproducible across two different ultrasound platforms in adults with known or suspected NAFLD. • Ultrasonic attenuation coefficient and backscatter coefficient are reproducible between two different ultrasound platforms in adults with NAFLD. • This inter-platform reproducibility may qualify quantitative ultrasound biomarkers for generalized clinical application in patients with suspected/known NAFLD.
Shear wave elastography correlates with liver fibrosis scores in pediatric patients with liver disease

While liver biopsy remains the gold standard, given the procedure risks and sampling errors, there is a need for reliable noninvasive biomarkers of hepatic fibrosis. Determine the accuracy of two-dimensional shear wave elastography (2-D SWE) in predicting the histological severity of liver fibrosis in pediatric patients with known or suspected liver disease. Subjects 0–18 years old with known or suspected liver disease and liver biopsy within 30 days (n=70) were included. Comparisons by 2-D SWE were made to a control group (n=79). Two-dimensional SWE was performed using the GE LOGIQ E9 system. Liver biopsy specimens were scored according to METAVIR and Ishak scoring systems using Spearman’s Rho correlation. Receiver operator characteristic (ROC) analysis, Kruskal-Wallis and Mann-Whitney U tests were conducted. Control group median 2-D SWE measurements were lower than in subjects with any degree of liver fibrosis (P<0.001). Those with METAVIR F0 and Ishak 0 scores had significantly lower median 2-D SWE measurements (1.35 m/s; 1.36 m/s) than those with more advanced liver disease (F1-F3: 1.49–1.62 m/s; 1–4: 1.45–1.63 m/s) (P<0.05 for all), whereas the 2-D SWE in the higher scores were similar. Results did not differ between METAVIR and Ishak scores for any degree of fibrosis. Fibrosis scores moderately correlated with median 2-D SWE measurements (rs=0.43). The area under the curve for F1 compared to combined control/F0 was 0.89 (95% confidence interval [CI] 0.83–0.95; P<0.001) with sensitivity of 94.6% and specificity of 78.6%. Results for Ishak score 1 were similar. The ideal cutoff value for identifying fibrosis was determined to be 1.29 m/s. The liver 2-D SWE measurements correlated with the histological liver fibrosis scores, regardless of the histopathological scoring system, although 2-D SWE was better at identifying patients with early fibrosis, not at distinguishing among the individual fibrosis levels. Two-dimensional SWE using the GE LOGIQ US system is useful for identifying pediatric patients at risk for liver fibrosis.
Daily perceived stress and time to pregnancy: A prospective cohort study of women trying to conceive.

Abstract Background Prior studies among women with impaired fecundity have consistently demonstrated a positive association between daily perceived stress and the ability to conceive. However, the effects of daily stress on time to pregnancy (TTP) among women with proven fertility is not known. Materials and Methods One hundred and forty-three women ages 18–35, in a relationship of proven fertility, who desired to conceive were included in the analysis. Daily diaries recording perceived stress (scale 0–10) were completed for up to 7 menstrual cycles or until pregnancy. Cox proportional hazards regression models were used to estimate the association between time-varying perceived stress tertiles (high [>4.1–7.2], moderate [>2.7–4.1], and low [0.1–2.7]) and adjusted fecundability odds ratio (aFOR), 95% confidence intervals (CI), after taking into account age, parity, education, time-varying caffeine and alcohol intake, fertility awareness tracking, and cycle intent to conceive. Results Among the 111 participants who completed daily diaries, 90 (81.1%) conceived. Women reporting high or moderate stress, versus low stress, had no difference in probability of achieving pregnancy (aFOR: 1.11 [95% CI: 0.58, 2.14]; and aFOR: 1.37 [0.71, 2.67]), respectively. Additional adjustment for intercourse frequency during narrow fertile window, or narrowing exposure focus to pre-ovulatory or pre-implantation stress did not appreciably alter the estimates. Conclusion Daily perceived stress was not adversely associated with TTP among women with proven fertility. While a growing body of evidence supports adverse effects of more severe stressful life events on female reproductive function, moderate psychological stress, commonly referred to as eustress, among relatively healthy women with proven fertility does not appear to adversely impact TTP.
Understanding Southeast Asian American male student engagement experiences with community college faculty members

Faculty–student engagement has been found to be important for male students of color success in community colleges. However, there is limited understanding of how Southeast Asian American (SEAA) ma...
An international systematic review of dementia caregiving interventions for Chinese families.

Objectives Older Asians and Chinese are among the least studied populations in the dementia caregiving literature. This review seeks to critically synthesize the literature on intervention characteristics, components and tailoring strategies for dementia family caregivers in Chinese communities globally. Methods Five electronic databases (PsychINFO, PubMed, CINAHL, ScienceDirect and Google Scholar) were searched for articles published between 1980 and July 2018. The protocol of this review was registered with PROSPERO (CRD42019132800). Results Twenty-nine unique interventions across 39 papers met inclusion criteria. Results from descriptive and thematic syntheses revealed that most interventions were psychoeducational, CBT-based, multicomponent, structured, and less than a year in duration. Disease education, management of behavioral and psychological symptoms of dementia, stress coping techniques, and referral to community resources were frequently included in interventions. Community-, culture- and language-focused strategies were used to tailor interventions. The most common tailoring strategies were: (a) using community networks and media for outreach and recruitment; (b) making translations and language adaptations to the intervention materials; and (c) focusing on trust and therapeutic alliance. Most interventions produced desired outcomes, particularly reducing caregiver burden and increasing self-efficacy. Conclusions To our knowledge, this is the first review to date that systematically synthesized the characteristics and tailoring of dementia caregiving interventions for Chinese families globally. Current findings suggest that most interventions are effective, although many only superficially address Chinese culture. Future research should incorporate Chinese values and cross-cultural challenges into caregiving interventions for deep-level adaptations that could potentially be more effective to engage and support Chinese caregivers.
Impact of 802.15.4 Radio Antenna Orientation on UAS Aerial Data Collection

This work uses experimental measurements to study the impact of network configuration and flight planning on Unmanned Aircraft System (UAS) assisted data collection in a 2.4GHz IEEE 802.15.4 outdoor aerial testbed. Our paper builds on previous work in UAS data collection from 802.15.4 outdoor sensor networks by conducting a novel investigation of the impact of antenna orientation on transceivers with external straight wire antennae. We study the effects of toroidal radiation and antenna polarization on signal strength, and we compare external antenna configurations to the commonly used embedded coiled antenna modules. We model our data using a Zero Inflated Negative Binomial (ZINB) model. For each hardware configuration and orientation, we identify the optimal altitude to fly a UAS. Our results show that choosing antenna configuration (including type and orientation) for an IoT network depends on the intended UAS collection flight plan.
Optimizing a Cogeneration sCO2 CSP–MED Plant Using Neural Networks

Defining optimal cogeneration system design requires the use of complex analyses capable of capturing dynamic processes within multiple subsystems and individual devices in parallel. This is due to...
Dynamics of beetle-killed snags following mountain pine beetle outbreaks in lodgepole pine forests

Abstract Snags (standing dead trees) are important components of forest ecosystems that, among other benefits, provide critical habitat for many species of wildlife, but also represent important safety concerns to firefighters, forest workers, and the public. We identified factors that influence the fall rates of lodgepole pines, Pinus contorta Dougl. ex Loud., killed by bark beetles during a severe regional-scale outbreak of mountain pine beetle, Dendroctonus ponderosae Hopkins, that occurred in 2004–2012. Data were obtained during annual assessments (2010–2019) of a network of 107 0.081-ha circular plots installed in P. contorta forests in Colorado, Idaho, Montana, Utah and Wyoming, U.S. A total of 3789 P. contorta snags were monitored, and in each case we recorded, among other variables, the year the snag was created and the year the snag fell to the forest floor. Among snag age classes (i.e., number of years since tree death), the highest number of snags (1046) were 12 years since death (YSD), and those 13 and 14 YSD exhibited the lowest fall rates to date (
Public Health Policy: Revising the Need for a Compensation System for Quarantine to Maximize Compliance

This Article briefly examines the history of quarantine, the legal authority that relates to the government's ability to order quarantine, and many of the adverse impacts related to quarantine. It explains how providing a mechanism for compensation limits the adverse impacts and furthers public health goals. The Article then examines and evaluates existing federal, state, and international laws, as well as private employer-based compensation structures that could be used to compensate individuals undergoing quarantine, and concludes that a simple and accessible state-based approach via standalone legislation provides the most workable means of providing compensation. The Article asserts that bipartisan dialogue, compromise, and planning-before the next infectious disease crisis-will be essential to creating a system that is both workable and equitable.
Early cognitive decline in symptomatic carotid stenosis is related to plaque inflammation and concomitant intracranial stenosis (P4.258)

Objective: To evaluate cognitive parameters of patients with symptomatic carotid stenosis at baseline and their natural course during 90 days of follow up. Background: Symptomatic carotid stenosis is associated with an increased risk of early stroke recurrence. Post-stroke vascular cognitive impairment is highly prevalent with significant functional consequences. However, reliable biomarkers for early prediction of cognitive decline are not well established. We postulated that regional hypoperfusion due to carotid stenosis would impair cognitive performance. Design/Methods: This ongoing prospective study included patients within 30 days of recent stroke and ipsilateral carotid stenosis (≥50%). Data regarding demographics and vascular risk factors were recorded. Cognitive parameters were assessed with the 30-point mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA). All patients underwent carotid duplex sonography and 18-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) of the carotid arteries. Embolic potential of the carotid plaque was estimated by the presence of spontaneous microembolic signals (MES) on extended transcranial Doppler monitoring of the middle cerebral arteries. Patients were followed prospectively for change in cognitive parameters. Results: Out of 39 patients, 8 (21%) demonstrated deterioration of their cognitive parameters (MMSE in 6, MOCA in 5 and both in 7) during 90-day follow up. Only high Standard Uptake Value (SUV) on PET (3.74 g/ml in cognitive-deterioration group versus 1.66 g/ml in the unaffected group; p=0.01) and presence of concomitant intracranial stenosis (p=0.01) were associated with cognitive deterioration. Of the 7 cases who underwent carotid revascularization, 5 (71%) demonstrated improved cognitive performance at day 90. Conclusions: Early cognitive decline is common among patients with symptomatic stenosis of the extracranial carotid artery, especially when associated with concomitant intracranial stenosis and plaque inflammation. Study Supported by: This study is supported by a grant from the National Medical Research Council, Singapore. Disclosure: Dr. Tan has nothing to disclose. Dr. Bharatendu has nothing to disclose. Dr. Paliwal has nothing to disclose. Dr. Teoh has nothing to disclose. Dr. Chan has nothing to disclose. Dr. Dong has nothing to disclose. Dr. Sinha has nothing to disclose. Dr. Sharma has nothing to disclose.
Acute neurological injury in pediatric patients with single-ventricle congenital heart disease.

OBJECTIVE Single-ventricle congenital heart disease (CHD) in pediatric patients with Glenn and Fontan physiology represents a unique physiology requiring the surgical diversion of the systemic venous return from the superior vena cava (Glenn) and then the inferior vena cava (Fontan) directly to the pulmonary arteries. Because many of these patients are on chronic anticoagulation therapy and may have right-to-left shunts, arrhythmias, or lymphatic disorders that predispose them to bleeding and/or clotting, they are at risk of experiencing neurological injury requiring intubation and positive pressure ventilation, which can significantly hamper pulmonary blood flow and cardiac output. The aim of this study was to describe the complex neurological and cardiopulmonary interactions of these pediatric patients after acute central nervous system (CNS) injury. METHODS The authors retrospectively analyzed the records of pediatric patients who had been admitted to a quaternary children’s hospital with CHD palliated to bidirectional Glenn (BDG) or Fontan circulation and acute CNS injury and who had undergone intubation and mechanical ventilation. Patients who had been admitted from 2005 to 2019 were included in the study. Clinical characteristics, surgical outcomes, cardiovascular and pulmonary data, and intracranial pressure data were collected and analyzed. RESULTS Nine pediatric single-ventricle patients met the study inclusion criteria. All had undergone the BDG procedure, and the majority (78%) were status post Fontan palliation. The mean age was 7.4 years (range 1.3–17.3 years). At the time of acute CNS injury, which included traumatic brain injury, intracranial hemorrhage, and cerebral infarct, the median time interval from the most recent cardiac surgical procedure was 3 years (range 2 weeks–11 years). Maintaining normocarbia to mild hypercarbia for most patients during intubation periods did not cause neurological deterioration, and hemodynamic profiles were more favorable as compared to periods of hypocarbia. Hypocarbia was associated with unfavorable hemodynamics but was necessary to decrease intracranial hypertension. Most patients were managed using low mean airway pressure (MAWP) in order to minimize the impact on preload and cardiac output. CONCLUSIONS The authors highlight the complex neurological and cardiopulmonary interactions with respect to partial pressure of arterial CO2 (PaCO2) and MAWP when pediatric CHD patients with single-ventricle physiology require mechanical ventilation. The study data demonstrated that tight control of PaCO2 and minimizing MAWP with the goal of early extubation may be beneficial in this population. A multidisciplinary team of pediatric critical care intensivists, cardiac intensivists and anesthesiologists, and pediatric neurosurgeons and neurologists are recommended to ensure the best possible outcomes.
Entangling the Legalities of Utopia: New Terrains of Entanglement among Traditional and Data Driven Social Credit Governance

This paper is an initial of an examination of the entanglement between conventional and "new form" legal systems and emerging data driven and social credit systems. The idea is to try to understand how two sets of systems, interlinked but autonomous, may now entangle as two quite distinct forms of legalities. Those interlinkages, in turn, suggest consequences for the character of each and their respective role in the organization and management of human collectives (states, global production chains, civil society, and the like). The objects of examination, these two families of legalities which find themselves opposed and connected, add a layer of complication and new ways of entangling well beyond that of the entanglement of traditional legalities (at least from my perspective) in a number of ways. Is it possible even at this early stage to attempt a rationalization of those encounters? That task is worth a try: the nature of the entanglement of conventional legalities with those of data driven legal orders may be rationalized at least as a preliminary matter.
MINDFULNESS SESSION: Being Intentional about Your Breaks (30 mins)

This session begins with a brief introduction into the concept of mindfulness and how mindful practices can enhance your quality of life and work. Mason resources for mindful practices will be shared and there will be time try some quick mindful movement activities. Mindful movements are gentle stretches that can help release tension and calm the mind. This practice includes fluid movements from qigong (similar to tai chi) and yoga poses. They are easy to do and just may offer a feeling of renewal.
Heparin Monitoring in Acute Thrombosis Associated With Antiphospholipid Antibody Syndrome

Antiphospholipid antibody syndrome is associated with recurrent thromboembolism and the presence of antibodies directed against negatively charged phospholipids. Despite significant hypercoagulability, patients with the disorder often have elevated baseline activated partial thromboplastin times. Although heparin is indicated for the treatment of acute thrombosis, heparin monitoring is complicated by laboratory test interference. A practical treatment approach involves patient-specific screening for a reagent insensitive to the presence of the inhibitor, and determination of a reagent-specific therapeutic range in seconds that corresponds to heparin serum concentrations of 0.2-0.4 U/ml. Other monitoring methods, including using the patient's baseline activated partial thromboplastin time or using an antifactor Xa activity assay, have not been reported or studied but may offer alternatives for heparin monitoring in patients with coagulation laboratory test interference associated with antiphospholipid antibody syndrome.
Interaction with newly synthesized and retained proteins in the endoplasmic reticulum suggests a chaperone function for human integral membrane protein IP90 (calnexin).

A cDNA clone encoding the human endoplasmic reticulum (ER) resident protein IP90 was isolated and sequenced. It predicts a transmembrane protein with a large ER luminal region showing sequence similarity to calreticulin and a short cytoplasmic domain containing a COOH-terminal RKPRRE sequence that may be relevant to its retention in the ER. It is 95% homologous to the canine ER membrane phosphorprotein called pp90 or calnexin (Wada, I., Rindress, D., Cameron, P. H., Ou, W.-J., Doherty, J. J., II, Louvard, D., Bell, A. W., Dignard, D., Thomas, D. Y., and Bergeron, J. J. M. (1991) J. Biol. Chem. 266, 19599-19610). Previously, in lymphocytes, we have characterized IP90 as a protein associated with partially assembled multichain proteins including the T cell receptor, the membrane immunoglobulin, and the heavy chain of the major histocompatibility complex class I molecules (Hochstenbach, F., David, V., Watkins, S., and Brenner, M. B. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 4734-4738). Here, we show that within a short metabolic labeling period, IP90 associates transiently with many different newly synthesized proteins. However, in a T cell line that cannot assemble a complete T cell receptor because it lacks the alpha subunit, the unassembled T cell receptor beta chains, which are retained in the ER, remain associated with IP90 throughout a prolonged chase time period. Together, these data offer further evidence suggesting that IP90 may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits.
Cost-efficient training strategies for space-time adaptive processing algorithms

Space-time adaptive processing (STAP) usually requires the estimation of large-dimension clutter covariance matrices. The mean loss in output SNR is a function of the number of statistically similar data samples used to estimate the covariance matrix. This number is generally 3 times the dimension of the covariance matrix or more. In nonhomogeneous clutter environments it is difficult to obtain this many statistically similar data samples using a data selection rule that is computationally simple. We present several new training strategies that select data samples from as close to the target range-gate as possible and simultaneously maintain a low computation count. A "training strategy" is the rule used to select data samples for covariance matrix estimation. A new training strategy is presented along with a recursion for efficient estimation of the clutter covariance matrix at each target range-gate. Also, a new training concept called freeze training is presented and shown to reduce the number of computations and to mitigate clutter discretes in nulled output data. A computation-count comparison is presented with each training strategy.
Direct spectrophotometric quantitation of steroid chromatograms. I. The measurement of corticosteroids.

Abstract In recent years, thin-layer chromatography (TLC) has become recognized as a valuable method for the separation and identification of closely related compounds. The development of a versatile spectrophotometric scanning device (1) has led us to evaluate the many factors involved in direct spectrophotometric quantitation of thin-layer chromatograms. In the past, direct spectrophotometric quantitation of paper chromatograms has been regarded, generally, as inferior to elution methods (2–6). However, the data to be presented suggest that, with the scanning arrangement to be described and careful planimetry, accurate, sensitive, and reproducible direct spectrophotometric measurements can be obtained.
Isolation, cDNA cloning, and characterization of an 18-kDa hemagglutinin and amebocyte aggregation factor from Limulus polyphemus.

An 18-kDa hemagglutinin which possesses the property of inducing both aggregation of amebocytes and agglutination of erythrocytes has been isolated from Limulus polyphemus amebocytes and purified by ion exchange chromatography. This nonglycosylated, single chain polypeptide with an M(r) of 18,506 and isoelectric point of 8.3 is stored exclusively in the large secretory granules of amebocytes. Based on the partial N-terminal amino acid sequence of 63 residues, DNA probes have been synthesized for screening a pBR322 cDNA library constructed from Limulus amebocytes. The cDNA coding for this protein reveals the presence of a 19-residue signal peptide preceding the 153-residue open reading frame. Northern blot analysis indicates the presence of a single mRNA species. The primary structure derived from the corresponding cDNA sequence reveals an internal homology consisting of two consensus sequences, Val-Asn-Asp/Ser-Trp-Asp and Glu-Asp-Arg-Arg-Trp. The formation of 5 disulfide bonds between 10 half-cysteines divides the molecule into three looped domains each containing the Glu-Asp-Arg-Arg-Trp repeating unit. One of the novel features of this protein is that it shares 37% identity with a 22-kDa mammalian extracellular matrix protein isolated from fetal bovine skin (Neame, P.J., Choi, H.U., and Rosenberg, L.C. (1989) J. Biol. Chem. 264, 5474-5479). The two proteins exhibit a similar pattern of looped domains, each domain containing a homologous consensus sequence (i.e. Glu-Asp-Arg-Arg-Trp). The overall structure of both proteins seems to be highly related, with the exception of an N-terminal tyrosine-rich region present only in the mammalian extracellular matrix protein. The functional properties of the two proteins are similar in that the Limulus 18-kDa protein agglutinates horse erythrocytes and aggregates Limulus amebocytes, and the mammalian 22-kDa protein is an effective adhesion promoter for dermal fibroblasts. On the basis of these unique properties, the newly characterized hemagglutinin has been termed Limulus 18K agglutination-aggregation factor (18K-LAF).
Nonlinear waves in thermo-magnetoelasticity II. Wave generation in a perfect electric conductor

Relying on a nonlinear continuum model of thermo-magnetoelasticity previously introduced by the authors, in which the heat capacity of the medium depends on strain and magnetic field, we investigate the effect of this dependence on the one-dimensional propagation of nonlinear, thermo-magnetoacoustic waves in an anisotropic (but centrosymmetric) half-space of a perfect electric conductor permeated by a constant magnetic field. The obtained formula for the relative variation of the phase velocity of the wave due to this dependence may be used, in combination with the proper experimental data, to predict the value of a material constant.
Late-Life Creativity

The older segment of the population is growing faster than any other age group. In the United States, those over 65 are projected to account for 20% of the nation, reflecting a worldwide pattern (McDonald, 1997; Perlmutter, 1990). Average life expectancy has not only increased but has led to two new categories of old age, the very-old and the old-old. There are more than 664 million people over 80 in the world, 1 for every 100 on earth, a number predicted to grow by another 370 million in 2050. The 135,000 centenarians in the United States in 1998, say fore- casters, will reach 2.2 million in the next 50 years. The upsurge of the aged is reflected in more than 1,000 college programs in gerontol- ogy, with several hundred at the graduate level, a 36-fold increase in funding from the National Institute on Aging in the last 25 years, to $685.6 million in a recent accounting, and more than a 10-times growth in the number of grants in the same period, valued at $722 million.
Nurses' Caring Attitude: Fall Prevention Program Implementation as an Example of Its Importance

BACKGROUND OF THE PROBLEM. Fall prevention programs are universally multidisciplinary, but nursing care plays the central role. Since October 2008, Medicare has no longer reimbursed acute care hospitals for the costs of additional care required due to hospital-acquired injuries (e.g., injurious falls). PROBLEM. However, fall prevention programs for hospitalized patients have had limited success, and multifaceted strategies for implementing fall prevention programs cannot guarantee success. It is possible that cultivating and sustaining a caring attitude among clinicians is often overlooked as an intervention strategy. METHOD. This article discusses the barriers to implementing fall prevention programs in acute care hospitals. The attributional theory of success and failure is used to analyze these barriers. In addition, the author discusses whether a lack of knowledge and/or a lack of caring attitude play a role as the underlying barriers to implementing a successful fall prevention program. A patient's story illustrates patients' expectations for the care environment to center on their needs. Possible educational strategies as interventions for fall prevention programs are discussed. FINDINGS. It is suggested that education goals for nurses need to not only promote their professional knowledge and skills in implementing a fall prevention program but also cultivate their caring attitudes.
Secretome Signature of Invasive Glioblastoma Multiforme

The incurability of malignant glioblastomas is mainly attributed to their highly invasive nature coupled with resistance to chemo- and radiation therapy. Because invasiveness is partially dictated by the proteins these tumors secrete we used SILAC to characterize the secretomes of four glioblastoma cell lines (LN18, T98, U118 and U87). Although U87 and U118 cells both secreted high levels of well-known invasion promoting proteins, a Matrigel invasion assay showed U87 cells to be eight times more invasive than U118 cells, suggesting that additional proteins secreted by U87 cells may contribute to the highly invasive phenotype. Indeed, we identified a number of proteins highly or exclusively expressed by U87 cells as compared to the less invasive cell lines. The most striking of these include ADAM9, ADAM10, cathepsin B, cathepsin L1, osteopontin, neuropilin-1, semaphorin-7A, suprabasin, and chitinase-3-like protein 1. U87 cells also expressed significantly low levels of some cell adhesion proteins such as p...
Dominant point matching algorithm

A novel dominant point matching algorithm is designed and developed for occluded object recognition. The developed algorithm is capable of grouping all scattered dominant points on an object boundary, due to occlusion, into a single representation for recognition. A set of handtools is selected to evaluate the performance of the algorithm and the results are encouraging.
Intervention and Capacity Considerations in Community-Based Deer Management: The Stakeholders’ Perspective

Community involvement with white-tailed deer (Odocoileus virginianus) management in suburban areas has increased recently, presenting wildlife agencies, interest groups, local governments, and other stakeholders with challenges and opportunities for collaboration. Community-based deer management requires that stakeholders involved have capacity to engage in situation analysis, decision making, and management implementation (in some cases). The authors interviewed 55 stakeholders involved in collaborative deer management in six suburban communities in New York and Massachusetts, identifying dimensions of stakeholder capacity and capacity-developing intervention for effective collaboration. Capacity dimensions identified included: partnerships, credibility, funding, relationships, common purpose, knowledge, and leadership. Intervention dimensions included: stakeholder involvement, education, communication, assessment, agency flexibility, and planning. Using a public-issue evolution model, this article descr...
Staging of pancreatic cancer with multidetector CT in the setting of preoperative chemoradiation therapy

Background Preoperative chemoradiation can potentially improve outcomes in patients with pancreatic cancer. This study addresses its effect on staging pancreatic cancer with multidetector computed tomography (MDCT).
Labeling of liver and plasma lecithins after injection of 1–2-14C-2-dimethylaminoethanol and14C-L-methionine-methyl to choline deficient rats

Groups of rats were fed a choline-deficient (CD) or a choline-supplemented (CS) diet for 15 hr. Labeling of liver and plasma cephalins and lecithins was followed with time after injection of14C-L-methionine-methyl or 1–2-14C-2-dimethylaminoethanol, either alone or together with3H-S-adenosyl-L-methionine-methyl. A reduced concentration of liver and plasma lecithins was found in CD rats. In the same animals, labeling of the phospholipid fractions was considerably greater and faster than in CS rats. Administration of choline to rats previously fed the CD diet resulted in both an increased concentration of liver and plasma lecithins and a reduction in the labeling of liver and plasma lecithins to levels seen in control rats. These results suggest that in CD rats, while the overall synthesis of lecithins may be reduced due to insufficient availability of choline, the synthesis of lecithins via stepwise methylation of cephalins may be increased.
The Development and Evaluation of Online Learning Modules to Deliver Lifespan Content in Human Behavior in Social Environment Courses

This article details the development and evaluation of a lifespan development computer modules that were used in human behavior in social environment courses. An anonymous, Web-based survey was developed to evaluate the modules. Supporting the first hypothesis, the majority of students (83.5%) found the modules to be a good learning alternative. The hypotheses that MSW students will experience more barriers to Web-based instruction and that students who previously mastered more content will spend less time on mobdules than students who previously mastered less content were not supported. Lessons learned provide implications for the use of computer-assisted instruction.