cssi/SciSciGPT-SciSciNet huggingface dataset:
Intragastric pH with oral vs intravenous bolus plus infusion proton-pump inhibitor therapy in patients with bleeding ulcers.

Background & Aims: Intravenous bolus plus infusion proton pump inhibitor (PPI) therapy is recommended for patients with bleeding ulcers and higher risk stigmata. If frequent oral dosing of PPIs provided similar antisecretory effect, this might be preferred based on ease and cost. Methods: Patients presenting with overt bleeding due to ulcers had intragastric pH probes placed after endoscopy and baseline pH recorded. They were randomly assigned to intravenous lansoprazole (90-mg bolus followed by 9-mg/h infusion) or oral lansoprazole (120-mg bolus followed by 30 mg every 3 hours). pH was recorded for 24 hours. Results: Intragastric pH was >6 for 67.8% of the study period with intravenous PPI (n 32) and 64.8% with oral PPI (n 34): difference, 3.0%; 95% confidence interval (CI): 9.2% to 15.2%. Intragastric pH was >6 for >60% of the study period in 22 (68.8%) patients receiving intravenous and 22 (64.7%) patients receiving oral PPI: difference, 4.0%; 95% CI: 18.7% to 26.8%. At 1 hour, mean pHs for intravenous vs oral were 5.3 0.4 vs 3.3 0.4, respectively (difference, 2.0; 95% CI: 0.8 –3.1; P .001). At >1.5 hours, 95% CIs of the differences for all hourly mean pHs included zero. Mean pH rose above 6 after 2–3 hours of intravenous PPI and 3– 4 hours of oral PPI. Conclusions: Frequent oral PPI may be able to replace the currently recommended intravenous bolus plus infusion PPI therapy in patients with bleeding ulcers, although the possibility that intravenous PPIs are superior cannot be definitively excluded given our relatively wide confidence intervals. Intravenous PPI provides more rapid increase in pH, reaching mean pH of 6 approximately 1 hour sooner than oral PPI.
Risk factors for necrotizing enterocolitis totalis: a case–control study

The objective of this study was to compare demographic and clinical events in three groups of preterm neonates: those with necrotizing enterocolitis totalis (NEC-T), those with NEC non-totalis (NEC non-T) and in preterm patients without NEC. This retrospective case–control study was conducted at Yale New Haven Children's Hospital using patient data from January 1991 to December 2007. Study patients were less than 36 weeks of gestational age (GA) at birth, without gastrointestinal (GI) malformations. Cases (NEC-T) were diagnosed at operation or at autopsy with observation of >80% necrosis of the GI tract. Two control groups were assigned: Group 1 or NEC non-T and Group II or Non-NEC. Two to four controls per case were matched to cases by GA at birth±2 weeks. Demographic and clinical data for the day of diagnosis and retrospectively up to 7 days preceding diagnosis were recorded for those with NEC-T and NEC. Group II controls were matched for date of birth and day of life, in addition to GA at birth. A total of 14 075 patients were admitted to the Newborn Special Care Unit during the study interval. Overall 328 patients (2.3%) developed NEC⩾Bell's Stage II; 39 patients met inclusion criteria for NEC-T case status; 148 NEC non-T and 110 non-NEC controls were assigned. In the comparison of NEC T and NEC non-T neonates, use of breast milk was associated with decreased risk of NEC-T, adjusted odds ratio (OR)=0.26, 95% confidence interval (CI) of OR=0.08–0.085, P=0.03. When NEC T and non-NEC patients were compared, having reached full-enteral feeds before the date of diagnosis of the matched case (adjusted OR=28.5, 95% CI of OR=2.7–299, P=0.005) and use of breast milk (adjusted OR=0.09, 95% CI of OR=0.02–0.56, P=0.01) were significantly different between the two groups. Breast milk usage was significantly associated with decreased occurrence of NEC-T in our comparison of NEC-T, NEC non-T and non-NEC patients. Although there were some differences, the majority of demographic and clinical variables assessed were not shown to be significantly different between cases and controls. This highlights the need for more biological data in assessing risk of developing NEC-T.
Endobronchial occlusive disease: Nd:YAG or PDT?

Patients with endobronchial occlusion commonly experience dyspnea, cough, hemoptysis, pneumonitis, and atelectasis. If luminal patency is not re-established, obstructive symptoms may progress to sepsis and death. Although the overall survival of patients with lung cancer may not be altered by relief of airway obstruction, the prognosis for this subset of patients may be improved by eliminating the septic complications of bronchial occlusion. Techniques to treat occluded bronchi include electro-fulguration, cryotherapy, brachytherapy, laser (CO2, Nd-YAG) therapy, and photodynamic therapy (PDT). These represent local forms of treatment and are intended to be palliative. Nd-YAG and PDT are the modalities more frequently utilized in this setting. Comparison of the two treatment forms may furnish insight regarding the appropriate role for each as individual therapies and as part of the armamentarium of cancer therapies.© (1991) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.

Protein kinase C (PKC) is known to play an important role in many signal transduction pathways involved in hormone release, mitogenesis, and tumor promotion. In continuation of our efforts to find ...
Effect of temperature on electrical and microstructural changes of coevaporated Ir‐Si alloy films

Electrical and microstructural changes of coevaporated Ir50Si50 have been studied as a function of temperature from room temperature to 970 °C. In situ resistivity measurements, in situ annealing and transmission electron microscopy, Rutherford backscattering spectroscopy and Seeman–Bohlin glancing angle incidence x‐ray diffraction were applied. In the as‐deposited state the alloy film is amorphous and exhibits semiconducting behavior. A two‐stage phase transformation occurs in the process of heating. The first transition from amorphous to crystalline IrSi is nucleation controlled. It is accompanied by an abrupt decrease in resistivity and was found to be dependent on the heating rate and chemical composition. The second crystalline‐to‐crystalline transformation is controlled by nonstoichiometry of the alloy film. An excess of Ir atoms leads to formation of Ir2Si at ∼640 °C while an excess of Si atoms leads to formation of IrSi3 at ∼710 °C. The second transition is independent of the heating rate. The for...
HHV-8 and AIDS-related CNS lymphoma.

Human herpesvirus 8 (HHV-81, the Kaposi9s sarcoma (KS)-associated herpesvirus, is closely related to the transforming Epstein-Barr virus (EBV) and may be detected in AIDS-related, EBV-containing, body-cavity-based lymphomas. Accordingly, we analyzed 27 EBV-positive, AIDS-related CNS lymphomas for HHV-8 sequences. Only one tumor yielded HHV-8 sequences; this tumor arose in a patient with concomitant systemic lymphoma and a history of KS. We conclude that HHV-8 is unlikely to have a major role in the pathogenesis of AIDS-related, EBV-associated CNS lymphomas.
Unmanned Vehcle Navigation and Control: A Fuzzy Logic Perspective

A general fuzzy logic based framework along with its application specific modifications is discussed to support, evaluate and justify the proposed perspective to unmanned vehicle autonomous navigation and control. Experimental and simulation results are included to validate and support implemented techniques and approaches to ground, aerial and underwater vehicles. A comparative study of classical and soft computing based controllers, designed to control small unmanned helicopters under hovering and cruising offers additional information related to the claim that fuzzy logic controllers may be implemented successfully when such helicopters perform non-aggressive flight patterns. The paper contribution is straight forward: it provides evidence of the usefulness and applicability of fuzzy logic as a viable alternative to using analytic approaches, and as a modeling tool that deals with imprecision and uncertainty
Insect Stage-Specific Adenylate Cyclases Regulate Social Motility in African Trypanosomes

ABSTRACT Sophisticated systems for cell-cell communication enable unicellular microbes to act as multicellular entities capable of group-level behaviors that are not evident in individuals. These group behaviors influence microbe physiology, and the underlying signaling pathways are considered potential drug targets in microbial pathogens. Trypanosoma brucei is a protozoan parasite that causes substantial human suffering and economic hardship in some of the most impoverished regions of the world. T. brucei lives on host tissue surfaces during transmission through its tsetse fly vector, and cultivation on surfaces causes the parasites to assemble into multicellular communities in which individual cells coordinate their movements in response to external signals. This behavior is termed “social motility,” based on its similarities with surface-induced social motility in bacteria, and it demonstrates that trypanosomes are capable of group-level behavior. Mechanisms governing T. brucei social motility are unknown. Here we report that a subset of receptor-type adenylate cyclases (ACs) in the trypanosome flagellum regulate social motility. RNA interference-mediated knockdown of adenylate cyclase 6 (AC6), or dual knockdown of AC1 and AC2, causes a hypersocial phenotype but has no discernible effect on individual cells in suspension culture. Mutation of the AC6 catalytic domain phenocopies AC6 knockdown, demonstrating that loss of adenylate cyclase activity is responsible for the phenotype. Notably, knockdown of other ACs did not affect social motility, indicating segregation of AC functions. These studies reveal interesting parallels in systems that control social behavior in trypanosomes and bacteria and provide insight into a feature of parasite biology that may be exploited for novel intervention strategies.
Downstream Effects of Speed Photo–Radar Enforcement and Other Speed Reduction Treatments on Work Zones

The effects of automated speed photo-radar enforcement (SPE) and traditional speed reduction treatments (speed feedback trailer, presence of police vehicles with emergency lights on and off, and combinations of the speed feedback trailer and police presence) on speed were studied at a location 1.5 mi downstream of the actual treatment (spatial effects). Three data sets from two Interstate highway work zones were used. Field data consistently showed significant spatial (downstream) effects for SPE. The combination of speed feedback trailer and police vehicle with emergency lights off had downstream effects in some cases but to a lesser degree than SPE. Other treatments showed no significant downstream effects. For free-flowing traffic, SPE reduced the average downstream speed by 2 to 3.8 mph for cars and by 0.8 to 5.3 mph for trucks. Also, SPE reduced speeding cars by 7.1% to 23.4% (except for cars in median in Data Set 1), and speeding trucks by 4.2% to 48.3% (except for trucks in shoulder in Data Set 3)....
Possible behavior of a diamond (111) surface in methane/hydrogen systems

A combined numerical and experimental investigation into the behavior of diamond (111) surfaces in plasma CVD reactors is presented. Numerically, semiempirical molecular orbital methods are used as a model of diamond (111) surfaces represented by a 20-atom carbon cluster plus surface species. The abstraction of hydrogen atoms by gas-phase hydrogen atoms, the coverage dependence of the heat of formation for submonolayers of CH3 and C2H groups coadsorbed with H, and the energy change for abstraction of H atoms from the surface by various radicals in the gas phase are examined. No barrier to abstraction is found, steric effects in achieving clusters of CH3 groups are large, and C2H and atomic oxygen are found to be the most energetically favored for removal of adsorbed H. Experimentally, relative concentrations of atomic H in the near-surface region as a function of added O2 mole fraction were measured. A weak dependence on O2 concentration is observed, but does not appear to be significant enough to account for observed changes in growth rate. This suggests that other radical species be investigated for their contribution to diamond film growth.
Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice.

The possibility that medroxyprogesterone acetate (MPA) has prenatal teratological effects was investigated in CD1 and A/J mice New Zealand (NZ) and Dutch Belted (DB) rabbits and Charles River (CR) rats. The mice and rabbits received a single daily sc injection of .1-3000 mg/kg for 3 6 or 9 consecutive days during Days 7-15 of gestation while rats were similarly treated during Days 8-16. Fetal malformations occurring in mice or rats exposed to the highest dose of MPA could not be attributed to the progestagen. However cleft palate was observed in 6 28 and 42% of the fetuses of NZ rabbits treated on Days 13-15 with 1 3 or 10 mg/kg respectively. Similar frequencies of cleft palate were found in the offspring of DB rabbits. The occurrence of cleft palate in these animals probably does not indicate an unusual risk of the abnormality in humans exposed to MPA.
Raising the Bar for the Training of College Teachers: An Interview with Victor Benassi

Victor A. Benassi earned his bachelor's degree from California State College and his PhD in psychology from the City University of New York. After working in the Department of Psychology at California State University at Long Beach, he moved to the University of New Hampshire (UNH) in 1982. He is currently Professor of Psychology and Professor of College Teaching. He has been one of the leaders of his department's long-standing Preparing Future Faculty (PFF) component of the PhD program. In 2003, this program received recognition from the American Psychological Association's (APA) Board of Educational Affairs for its innovation and creativity. He has also played a part, along with several colleagues, in facilitating the development of UNH's academic program in college teaching. UNH received the 2002 Theodore M. Hesburgh Award for Faculty Development to Enhance Undergraduate Teaching (Certificate of Excellence) in recognition of this program. Benassi has received several awards within UNH for his scholarsh...
Cell-surface transglutaminase promotes fibronectin assembly via interaction with the gelatin-binding domain of fibronectin: a role in TGFbeta-dependent matrix deposition.

Assembly of fibronectin into a fibrillar matrix is critical for regulation of cell growth and migration, embryogenesis and wound healing. We have previously shown that cell-surface tissue transglutaminase serves as an integrin-binding adhesion coreceptor for fibronectin. Here we report that transglutaminase strongly promotes fibronectin assembly mediated byα 5β1 integrin. This effect is independent from transglutaminase-mediated enzymatic crosslinking of fibronectin and separate from the ability of transglutaminase to stimulate cell spreading. Surface transglutaminase increases the binding of fibronectin to cells via interaction with its gelatin-binding domain that contains modules I 6 II 1,2 I 7-9 and lacks integrin-binding motifs. The gelatin-binding fragment of fibronectin binds to surface transglutaminase on cells in suspension but does not interact with cell monolayers where surface transglutaminase is occupied by fibronectin. Surface transglutaminase colocalizes with growing fibronectin fibrils at early timepoints of matrix formation and remains codistributed with fibronectin matrices thereafter. The observed stimulation of matrix assembly by transglutaminase is blocked by the gelatin-binding fragment of fibronectin, but is not strongly perturbed by its N-terminal fragment consisting of modules I 1-5 . These results implicate an interaction between transglutaminase and the gelatin-binding domain of fibronectin in matrix assembly and suggest its role in initiation of fibrillogenesis. However, blocking antibodies against α5β1 integrin or the cell-binding fragment of fibronectin that contains modules III 2-11 most strongly suppress matrix formation and abolish the effects of transglutaminase. Hence, transglutaminase cooperates with but can not substitute for α5β1 integrin in fibronectin assembly. Treatment of fibroblasts with transforming growth factor β (TGFβ) significantly increases surface expression of transglutaminase and its association with β1 integrins, but not withα Vβ3 integrin. TGFβ enhances the binding of fibronectin to the cell surface and elevates matrix formation, whereas antibody against transglutaminase or the gelatin-binding fragment of fibronectin suppresses these effects, indicating an involvement of transglutaminase in TGFβ-dependent fibronectin assembly. Therefore, TGFβ-induced fibronectin matrix deposition during normal wound healing or fibrotic disorders may depend on upregulation of integrin-associated surface transglutaminase.
Recruiting EFNEP participants: process and materials.

In response to hunger in the United States, the Expanded Food and Nutrition Education Program (EFNEP) was created in 1968 to provide information about nutritious food choices, food safety, food budgeting, and physical activity to adults and children with limited resources. The Expanded Food and Nutrition Education Program is taught by paraprofessionals who come from the target population. According to Colorado State University EFNEP, families are usually referred to EFNEP by program participants and graduates; community agencies affiliatedwith the EFNEP also refer adults and children. Prior to this project, Colorado EFNEP did not use any printedmaterials to recruit potential EFNEP participants, similar to the lack of recruitment materials for potential EFNEP agency partners.
Is adaptation of the Word Accentuation Test of Premorbid Intelligence necessary for use among older, Spanish-speaking immigrants in the United States?

Adaptations of the National Adult Reading Test (NART) for assessing premorbid intelligence in languages other than English requires (a) generating word-items that are rare and do not follow grapheme-to-phoneme mappings common in that language, and (b) subsequent validation against a cognitive battery normed on the population of interest. Such tests exist for Italy, France, Spain, and Argentina, all normed against national versions of the Wechsler Adult Intelligence Scale. Given the varieties of Spanish spoken in the United States, the adaptation of the Spanish Word Accentuation Test (WAT) requires re-validating the original word list, plus possible new items, against a cognitive battery that has been normed on Spanish-speakers from many countries. This study reports the generation of 55 additional words and revalidation in a sample of 80 older, Spanish-dominant immigrants. The Bateria Woodcock-Munoz Revisada (BWM-R), normed on Spanish speakers from six countries and five U.S. states, was used to establish criterion validity. The original WAT word list accounted for 77% of the variance in the BWM-R and 58% of the variance in Ravens Colored Progressive Matrices, suggesting that the unmodified list possesses adequate predictive validity as an indicator of intelligence. Regression equations are provided for estimating BWM-R and Ravens scores from WAT scores. (JINS, 2006, 12, 391–399.)
Genome Sequencing of 15 Clinical Vibrio Isolates, Including 13 Non- O1/Non-O139 Serogroup Strains

We present draft genome sequences of 15 clinical Vibrio isolates of various serogroups. These are valuable data for use in studying Vibrio cholerae genetic diversity, epidemic potential, and strain attribution.
A Framework for the Study of Personality and Political Behaviour

Variance in how citizens interact with the political world constitutes one of many classes of individual difference. Understanding the antecedents of this variance is the central objective for students of political behaviour, and researchers draw on numerous factors in addressing this task. Unfortunately, one potentially vital factor, personality, has received only sporadic attention in recent decades. Neglect of personality was understandable for many years, as psychological research on personality failed to produce concise taxonomies applicable to the study of politics. As the present analysis demonstrates, however, this situation has changed. Research on personality has gained new footing with the emergence of a series of five-factor models, and these frameworks hold great potential for the study of political behaviour. This thesis is advanced in a two-part analysis. First, we outline how and why our understanding of citizen politics may be improved through application of five-factor models of personality. In doing so, we focus on the components of one specific taxonomy, the Big Five lexical model. Secondly, using three datasets, we explore the link between the Big Five personality factors and a wide array of political attitudes and behaviours. Results reveal that all facets of personality captured by the Big Five framework matter for citizen politics, and that personality effects operate on virtually all aspects of political behaviour. These findings demonstrate the insight that can emerge with further application of broad-scale models of personality.
Looking for Identity in the Muslim World

Dramas of Nationhood: The Politics of Television in Egypt. Lila Abu-Lughod. Chicago: University Chicago Press, 2005. 319 pp. Memories of State: Politics, History, and Collective Identity in Modern Iraq. Eric Davis. Berkeley: University of California Press, 2005. 385 pp. Religion, Social Practice, and Contested Hegemonies: Reconstructing the Public Sphere in Muslim Majority Societies. Armando Salvatore and Mark LeVine, eds. New York: Palgrave Macmillan, 2005. 249 pp. Contesting Rituals: Islam and Practices of Identity Making. Pamela Stewart and Andrew Strathern, eds. Durham, NC: Carolina Academic Press, 2005. 239 pp.
The nature of light : A physical model of the photon

Abstract The dualistic behavior of light has always presented a problem to scientists in general, and spectroscopists in particular. A model of a photon has been proposed which has mass, and a matched positive and negative charge. The properties of the proposed particle would be expected to behave as a particle usually behaves, but under certain circumstances a group of such particles would exhibit wave-like properties. Several classical phenomena are examined and interpreted in terms of the proposed model.
Therapeutic agents for attention deficit disorders

Attention deficit hyperactivity disorder (ADHD) is a syndrome that affects young children, manifesting itself through inappropriate behaviours and learning difficulties and persisting in many instances into adulthood. Treatment with stimulants, such as methylphenidate, is often sufficient but carries with it some risk for the emergence of unwanted side effects that can influence compliance, particularly with children. Newer agents and novel mechanisms for achieving control of the symptoms associated with ADHD are proposed in recent patents and applications and are presented in this review.
F#!%ing Rudeness Predicting the Propensity to Verbally Abuse Strangers

In an online survey study (n = 275), several demographic and personality variables were used to predict scores on the Rudeness Scale, a new measure of the propensity to verbally abuse strangers. Th...
Numerically stable fast recursive least-squares transversal filters

The problem of numerical stability of fast recursive least-squares transversal filter (FTF) algorithms is addressed. The prewindowing case with exponential weighting is considered. A framework for the analysis of the error propagation in these algorithms is developed. Within this framework, it is shown that the computationally most efficient 7N form (dealt with by G. Carayanmis et al. (1983) and by J.M. Cioffi (1984)) is exponentially unstable. By introducing redundancy in this algorithm, feedback of numerical errors becomes possible. This leads to a numerically stable FTF algorithm with complexity 9N. The results are presented for the complex multichannel joint-process filtering problem. >
THE MANAGEMENT OF SEPSIS FOLLOWING INTRAMEDULLARY FIXATION FOR FRACTURES OF THE FEMUR.

A review of fourteen patients treated for sepsis following intramedullary fixation of fractures of the femoral shaft is presented. The management of these complicated fractures is discussed from the standpoint of antibiotics, rod fixation, drainage, sequestrectomy, and external support. The results are evaluated with respect to union of the fracture, eradication of sepsis, and recovery of joint function. A plea is made for the maintenance of rigid internal fixation, even in the face of seemingly disastrous infection, in order to achieve union of the fracture.
Family Planning to Become a Way of Life for the People of India

As the death rate in India fell from 4.86% in 1921 to .16% in 1969 the birthrate decreased from 4.92% to 4.3%. The current net rate of growth increases the population by 13 million persons per year. The first 5-year plan (1951-1955) concentrated on research and program planning. The second plan (1956-1960) emphasized use of mass communication provision of clinical referral services training of personnel provision of supplies and research. The major aim of the third 5-year plan (1961-1966) was to accelerate the rate of adoption of family planning. Any future family planning plans should take into account the tradition of high fertility the communication difficulties of reaching the isolated rural population and the problems of developing a national organization and training and employing family planning workers who understand the communities and speak the local languages so they can create acceptance of small families among the people. Recreational facilities should be increased. At the present time there is no indigenous source of manufactured contraceptives and no established distribution channel to reach Indias millions. It is concluded that population education among adult school teacher and community leader groups will create awareness among the people that limitation of the number of children and welfare of the whole family are both concerns of family planning.
Optical Detection of Terahertz Using Nonlinear Frequency Upconversion

We describe and demonstrate sensitive room-temperature detection of terahertz radiation by nonlinear upconversion to the 1550 nm regime. We rely on telecomm components, achieving a highest reported to date terahertz-to-optical photon conversion efficiency of 0.001%.
Immobilized Bisdiazaphospholane Catalysts for Asymmetric Hydroformylation

Condensation reactions of enantiopure bis-3,4-diazaphospholanes (BDPs) that are functionalized with carboxylic acids enable covalent attachment to bead and silica supports. Exposure of tethered BDPs to the hydroformylation catalyst precursor, Rh(acac)(CO)2, yields catalysts for immobilized asymmetric hydroformylation (iAHF) of prochiral alkenes. Compared with homogeneous catalysts, catalysts immobilized on Tentagel resins exhibit similarly high regioselectivity and enantioselectivity. When corrected for apparent catalyst loading, the activity of the immobilized catalysts approaches that of the homogeneous analogues. Excellent recyclability with trace levels of rhodium leaching are observed in batch and flow reactor conditions. Silica-bound catalysts exhibit poorer enantioselectivities.
Exploring the collective hospice caregiving experience

Abstract Background: Collective caregiving, performed by caregivers working in pairs (informal primary and secondary caregivers working together), is common in the hospice setting. Research suggests that caregiving pairs may experience different caregiver outcomes. However, little is known about how caregiving pairs differ from solo caregivers (informal primary caregivers) on outcome measures. Objective: The goal of this study was to determine whether being in a caregiver pair affected caregiver anxiety and depression and how outcomes changed over time. Design: A mixed model analysis was used. Setting/subjects: Hospice caregivers (260 solo caregivers and 44 caregivers in 22 pairs) who participated in a larger, randomized controlled trial completed caregiver measures upon hospice admission and periodically until the death of the patient or hospice decertification. Measurements: Measured were caregiver quality of life, social support, anxiety, and depression. Results: Caregiver pairs had higher anxiety and ...
‘Religion’ Versus ‘Rights’: Why We are Wrong about ‘Defamation of Religions’

Since 1999, ‘Muslim’ countries have consistently pushed what have come to be known as the ‘Defamation of Religion’ resolutions in United Nations and human rights organizations. These resolutions aim to limit freedom of expression in order to protect religion, primarily Islam, against what its supporters see as a campaign of stereotyping and negative representation of religion on the part of the media in the West. The proliferation of these resolutions has resulted in a considerable opposition, especially in the West. The liberal scholarship has viewed these resolutions as being against freedom of expression and religious freedom.In this paper, I have taken a position against DoR, but I have not relied on the predominant discourse against it, which has been based on human rights. Rather, I argue that DoR is a deeply flawed because it is misplaced. One, the way DoR is conceived is intimately connected with the growing rejection of Muslim identity in Europe; and two, this rejection of Muslim identity is not a result of the religion-rights binary, but rather the result of an ethical and political crisis of multiculturalism within Europe. I claim that this crisis follows from the construction of the cultural other as a threat to the coherence of European society. Thus, I claim that not only are the supporters of the DoR resolutions wrong in pushing for them, but that the critics of the resolutions have also failed in being fair to the broader problem which has resulted in the resolutions. Once these two claims are recognized, it would appear that DoR is seeking to bark up the wrong tree. The concept seeks to address an essentially political problem through juridical means, which threatens to mystify this crisis and make it far more difficult to find a solution to it. I see the religion-rights dichotomy in the DoR rhetoric to be precisely a result of this mystification, thus making DoR an unfounded and misplaced language for understanding issues of tolerance and respect for diversity.
Photo-nano immunotherapy for metastatic cancers (Conference Presentation)

We constructed a multifunction nano system SWNT-GC and investigated the synergize photothermal and immunological effects. Here, we improve the SWNT-GC nano system and design a new synergistic nano-particle, both have the photothermal effects and immunological effects. We investigate the therapeutic effects and detect the immune response with metastatic mouse tumor models. We also study the therapeutic mechanism after treatment in vitro and in vivo. With the enhancement of nano-materials on photothermal effects, laser treatment could destroy primary tumor and protect normal tissue with low dose laser irradiation. With the immunological effects of nano-materials, the treatment could trigger specific antitumor immune response, to eliminate the metastasis tumor. It is providing a promising treatment modality for the metastatic cancers.
Circumferential Aortic Endarterectomy Followed with Immediate Infrarenal Clamping Obviates Suprarenal Clamping for Juxtarenal Aortoiliac Occlusion

Background Traditional open surgery for juxtarenal aortoiliac occlusive disease (AIOD) requires suprarenal aortic cross-clamping (SRCC), which is associated with high incidence of acute kidney injury (AKI). This study was to compare the outcomes of circumferential aortic endarterectomy followed by immediate infrarenal cross-clamping (IRCC) with the traditional approach of SRCC during surgery for juxtarenal AIOD. Methods A 10-year retrospective review of 87 patients who underwent open surgery for AIOD at our University Medical Center was performed. There were 52 males and 35 females (mean age of 52 years). Multivariate analysis was performed to assess operative time, blood loss, incidence of AKI, 30-day mortality, and recurrent aneurysm/pseudoaneurysm. Results Thirty-seven patients were found to have juxtarenal AIOD, which were divided into SRCC ( n = 25) and IRCC ( n = 12). Ten patients from the SRCC developed AKI versus 1 from the IRCC (30% vs. 8.3%, P = 0.04). SRCC demonstrated increased blood loss (1,681 vs. 591 mL, P = 0.004). Mean operative time was less in the IRCC group (5 vs. 7 hr, P = 0.0001). Thirty-day mortality in the SRCC group was 1 and 0 in the IRCC group, respectively. Recurrent aneurysm or pseudoaneurysm was not identified in endarterectomized aorta up to 4-year follow-up. Conclusions Circumferential aortic endarterectomy followed with immediate IRCC is a feasible, safe, and effective approach for juxtarenal AIOD in properly selected patients. It may be associated with lower rates of AKI, intraoperative bleeding, operating room time, and length of hospital stay, when compared with the traditional SRCC.
Augmented dictionary learning for motion prediction

Developing accurate models and efficient representations of multivariate trajectories is important for understanding the behavior patterns of mobile agents. This work presents a dictionary learning algorithm for developing a part-based trajectory representation, which combines merits of the existing Markovian-based and clustering-based approaches. In particular, this work presents the augmented semi-nonnegative sparse coding (ASNSC) algorithm for solving a constrained dictionary learning problem, and shows that the proposed method would converge to a local optimum given a convexity condition. We consider a trajectory modeling application, in which the learned dictionary atoms correspond to local motion patterns. Classical semi-nonnegative sparse coding approaches would add dictionary atoms with opposite signs to reduce the representational error, which can lead to learning noisy dictionary atoms that correspond poorly to local motion patterns. ASNSC addresses this problem and learns a concise set of intuitive motion patterns. ASNSC shows significant improvement over existing trajectory modeling methods in both prediction accuracy and computational time, as revealed by extensive numerical analysis on real datasets.
Foundations of reusable and interoperable facet models using category theory

Faceted browsing has become ubiquitous with modern digital libraries and online search engines, yet the process is still difficult to abstractly model in a manner that supports the development of interoperable and reusable interfaces. We propose category theory as a theoretical foundation for faceted browsing and demonstrate how the interactive process can be mathematically abstracted. Existing efforts in facet modeling are based upon set theory, formal concept analysis, and light-weight ontologies, but in many regards, they are implementations of faceted browsing rather than a specification of the basic, underlying structures and interactions. We will demonstrate that category theory allows us to specify faceted objects and study the relationships and interactions within a faceted browsing system. Resulting implementations can then be constructed through a category-theoretic lens using these models, allowing abstract comparison and communication that naturally support interoperability and reuse.
Matching games for wireless networks with energy cooperation

We consider a wireless ad hoc network composed of N transmitters and M receivers which are all selfish in the sense that they wish to optimize their individual utilities rather than a network wide utility. Each node can acquire energy from a supplier at a price to power the transmission or reception of data. For such a network, we consider a matching game played between the transmitters and the receivers. The transmitters compute the optimal rate for them and propose this to a receiver. The receivers determine the best proposal they have received to maximize their utilities. We identify the optimal decisions for all nodes and the resulting utilities. We next consider a Vickrey auction between transmitters which have proposed to the same receiver. We show that the transmitters can compete with each other by offering energy transfer to the receiver. The energy transfer reduces the processing costs of the receiver and influences its decision, thereby pointing to the merit of energy cooperation. We observe that populating the network with additional nodes generally results in more options for all nodes to choose from, and larger rates for the entire network, which are improved even further by energy cooperation.
Next generation sequencing (NGS) in resectable non-small cell lung cancer (NSCLC): Therapeutic implications.

8541Background: Tumor molecular profiling to direct therapy is standard for patients with advanced lung adenocarcinoma (AC) but is not routine in early stage NSCLC. Clinical trials are only beginning to test this approach for postoperative adjuvant therapy. After systematic preoperative consent and tumor/blood acquisition, we analyzed molecular profiling data in resectable NSCLC to enhance clinical trial participation and design. Methods: Prospective genomic analysis of resectable NSCLC was initiated in 2015 using MSK-IMPACT, a multiplexed NGS assay that detects base substitutions, short indels, copy number alterations and select gene rearrangements involving 341 (v1) or 410 (v2) cancer associated genes. Frequencies of mutations are summarized by histology (AC or squamous cell). AC further classified by histologic predominance as good (lepidic, MIA), intermediate (acinar, papillary), poor (micropapillary, solid) prognosis. Results: 123 tumors from 119 consecutive patients (4 synchronous 10); median age 67...
Adherence to antiepileptic drugs among diverse older Americans on Part D Medicare

Abstract Introduction Older minority groups are more likely to have poor AED adherence. We describe adherence to antiepileptic drugs (AEDs) among older Americans with epilepsy. Methods In retrospective analyses of 2008–2010 Medicare claims for a 5% random sample of beneficiaries augmented by minority representation, epilepsy cases in 2009 were those with ≥ 1 claim with ICD-9345.x or ≥ 2 with 780.3x, and ≥ 1 AED. New-onset cases had no such claims or AEDs in the year before the 2009 index event. We calculated the Proportion of Days Covered (PDC) (days with ≥ 1 AED over total follow-up days) and used logistic regression to estimate associations of non-adherence (PDC Results Of 36,912 epilepsy cases (19.2% White, 62.5% African American (AA), 11.3% Hispanic, 5.0% Asian and 2% American Indian/Alaskan Native), 31.8% were non-adherent (range: 24.1% Whites to 34.3% AAs). Of 3706 new-onset cases, 37% were non-adherent (range: 28.7% Whites to 40.5% AAs). In adjusted analyses, associations with minority group were significant among prevalent cases, and for AA and Asians vs. Whites among new cases. Among other findings, beneficiaries from high-poverty ZIP codes were more likely to be non-adherent than their counterparts, and those in cost-sharing drug benefit phases were less likely to be non-adherent than those in deductible phases. Conclusion About a third of older adults with epilepsy have poor AED adherence; minorities are more likely than Whites. Investigations of reasons for non-adherence, and interventions to promote adherence, are needed with particular attention to the effect of cost-sharing and poverty.
Message from the Dean and Director

Texas A&M International University's college of Education takes pride in presenting The Journal of Border Eduactional Research.Â it is the intent of this scholarly endeavor to provide an avenue for educators to attain effective educational research practices, particularlly such as practices apply to South Texas education.
Wearing Well-being: Using Context Mapping toward the Development of Garment Therapy for Elderly Populations

Few forms of human behavior are more pervasive than the use of textiles. Shelter and clothing textile products play a vital role in meeting basic human needs. Clothes are imbued with memories, intertwined with our histories and identities, interwoven into the "fabric of our lives" (Goett, 2008). Often in late stage/assisted living scenarios, care priorities shift from curative measures; the focus often changes to palliative care for the relief of pain, symptoms, and emotional stress. The purpose of this study is to better understand the impact of co-creative design approaches in late-stage eldercare through the development of wearable narratives, garment therapies that are visual, tactile and powerful to the user/creator. We concentrate on developing a design approach that assists in structuring and stimulating narratives. The objective is to understand the mechanisms by which co-creative design can engage "wearers" of design in the creation of wearable therapies that promote well-being. We hypothesize that the textile and garment creation is, in itself, a valuable theraputic tool. Findings from the study revealed that using this design approach to create a textile narrative was a positive experience for the participants. We found interviews and observations of the participants beneficial for generating individualized imagery for the contextmapping exercise. Allowing participants to express themselves through the imagery from the collages was an accessible method for them to contribute to the design process. We found this process both informational and inspirational in creating wearable narratives.
Increasing the Tick: Examining the Impact of the Tick Size Change on Market Fee Venues

This paper investigates the effects of an increase in tick size on order and trading flow across market fee venues. Using the pilot firms in the SEC’s Tick Size Pilot Program, we document trade and order volume declines significantly on maker-taker fee venues after the tick size implementation. Further, our results indicate that the inverted fee venue, taker-maker, experiences a significant increase in both trade and order volume. Our results are consistent with Foucault, Kadan, and Kandel (2013) in that a tick size adjustment has a substantial influence in the market participation in maker-taker fee venues. Additionally, we analyze the effects of the tick size change on measures of hidden and algorithmic trading, finding that measures of both hidden and algorithmic trading decline with an increasing tick size, this is strongly moderated by the differences in the maker-taker and taker-maker fee venues.
Humanized mouse model supports development, function, and tissue residency of human natural killer cells.

Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. Here, we describe a human interleukin 15 (IL15) and human signal regulatory protein alpha (SIRPA) knock-in mouse on a Rag2-/- Il2rg-/- background (SRG-15). Transplantation of human hematopoietic stem and progenitor cells into SRG-15 mice dramatically improved the development and functional maturation of circulating and tissue-resident human NK and CD8+ T cells and promoted the development of tissue-resident innate lymphoid cell (ILC) subsets. Profiling of human NK cell subsets by mass cytometry revealed a highly similar expression pattern of killer inhibitory receptors and other candidate molecules in NK cell subpopulations between SRG-15 mice and humans. In contrast to nonobese diabetic severe combined immunodeficient Il2rg-/- (NSG) mice, human NK cells in SRG-15 mice did not require preactivation but infiltrated a Burkitt's lymphoma xenograft and efficiently inhibited tumor growth following treatment with the therapeutic antibody rituximab. Our humanized mouse model may thus be useful for preclinical testing of novel human NK cell-targeted and combinatory cancer immunotherapies and for studying how they elicit human antitumor immune responses in vivo.
The Impact of the School Counselor Supervision Model on the Self-Efficacy of School Counselor Site Supervisors.

Supervision is a critical element in the professional identity development of school counselors; however, available school counseling-specific supervision training is lacking. The authors describe ...
Examining the Link Between Exercise and Positive Relationship Events in Clinical Couples

ABSTRACTThis study contributes to the literature on potential interventions couple therapists can use outside therapy for couples. We examine this research question: Are couples that exercise on a given day more likely to experience positive events in their relationship that day? Participants were 33 couples in a treatment-as-usual setting who completed the Daily Diary of Events in Couple Therapy for up to the first 28 days they are in therapy. Multinomial logistic regression showed increased women's daily hours of exercise were significantly associated with an increased report of daily positive events for both men and women. Men's daily hours of exercise were not significantly related to daily positive events reported by either partner.
Beta-adrenergic signaling on neuroendocrine differentiation, angiogenesis, and metastasis in prostate cancer progression

Prostate cancer is a complex, heterogeneous disease that mainly affects the older male population with a high-mortality rate. The mechanisms underlying prostate cancer progression are still incompletely understood. Beta-adrenergic signaling has been shown to regulate multiple cellular processes as a mediator of chronic stress. Recently, beta-adrenergic signaling has been reported to affect the development of aggressive prostate cancer by regulating neuroendocrine differentiation, angiogenesis, and metastasis. Here, we briefly summarize and discuss recent advances in these areas and their implications in prostate cancer therapeutics. We aim to provide a better understanding of the contribution of beta-adrenergic signaling to the progression of aggressive prostate cancer.
Flexible Air-Jet Tooling for Vibratory Bowl Feeder Systems

Vibratory bowl feeders (VBFs) are machines that feed various small parts in large volume automatic assembly systems. Their shortcomings, like inflexibility and the propensity to jam, stem from the use of mechanical orienting devices. Air jet based orienting devices can be implemented to overcome these limitations. Applications of passive and active air jet based orienting devices that replace conventional devices for the VBF are discussed. Passive devices, which reject incorrectly oriented parts, are discussed first. Active air jet based orienting devices are introduced to further improve the flexibility of VBFs. Since active devices reorient parts into a desired orientation, the part motion under their influence is analyzed. A number of tests demonstrate the feasibility and advantages of these new orienting devices.
Nonlinear Partial Differential Equations

In this chapter we turn our attention to the study of the dynamical properties of solutions of nonlinear partial differential equations. We are especially interested here in those nonlinear evolutionary equations which arise in the analysis of two broad classes of partial differential equations: parabolic evolutionary equations and hyperbolic evolutionary equations. While our usage of the terms “parabolic” and “hyperbolic” in this context is motivated by related concepts arising in the basic classification of partial differential equations, we will attribute these terms, instead, to certain dynamical features of the linear ancestry of the underlying nonlinear problems. More precisely, the linear prototypes of the partial differential equations of interest here include the heat equation and the wave equation: $${\partial _t}u - \nu \Delta u = 0\;and\;\partial _t^2u - \nu \Delta u = 0,$$ on a suitable domain Ω in ℝ d , with various boundary conditions and initial conditions.