cssi/SciSciGPT-SciSciNet huggingface dataset:
Does vascular endothelial growth factor (VEGF) and inhibition of apoptosis improve neovascularization in nonhuman primate, ovarian heterotopic transplants?

OBJECTIVE: While ovarian tissue banking with subsequent transplantation is an effective strategy for preserving fertility, the process is relatively inefficient. We hypothesize that VEGF and inhibition of apoptosis with FTY720 may improve neovascularization and survival of ovarian tissue transplants in the rhesus macaque, and that the abdomen may be a better site for heterotopic transplantation than the arm. DESIGN: Prospective, controlled, nonhuman primate model. MATERIALS AND METHODS: Ovaries from10 reproductive-aged monkeys, were cut into 0.5 mm thin cortical fragments (20-32/animal) and immediately transplanted sc to the arm or abdomen. Tissue on the right side was transplanted with FTY 720 or VEGF via microspheres or in a fibrin gel. Tissue transplanted on the left served as controls. Tissue was explanted at 4 or 7 days postoperatively, fixed, sectioned, and stained for vessels with CD31. Vessel density was calculated using a stereological approach and expressed as a percentage of the total graft examined. RESULTS: Graft recovery ranged from 50-100%. Vessels were identified in all groups by 4-7 days post-transplantation. There were no significant differences in vessel density between grafts transplanted with FTY720 and VEGF vs. controls (see table). There was a trend towards increased vascularization in grafts transplanted to the abdomen.
Loss of endophilin-B1 exacerbates Alzheimer’s disease pathology

Endophilin-B1, also known as Bax-interacting factor 1 (Bif-1, and encoded by SH3GLB1), is a multifunctional protein involved in apoptosis, autophagy and mitochondrial function. We recently described a unique neuroprotective role for neuron-specific alternatively spliced isoforms of endophilin-B1. To examine whether endophilin-B1-mediated neuroprotection could be a novel therapeutic target for Alzheimer's disease we used a double mutant amyloid precursor protein and presenilin 1 (APPswe/PSEN1dE9) mouse model of Alzheimer's disease and observed that expression of neuron-specific endophilin-B1 isoforms declined with disease progression. To determine if this reduction in endophilin-B1 has a functional role in Alzheimer's disease pathogenesis, we crossed endophilin-B1(-/-) mice with APPswe/PSEN1dE9 mice. Deletion of endophilin-B1 accelerated disease onset and progression in 6-month-old APPswe/PSEN1dE9/endophilin-B1(-/-) mice, which showed more plaques, astrogliosis, synaptic degeneration, cognitive impairment and mortality than APPswe/PSEN1dE9 mice. In mouse primary cortical neuron cultures, overexpression of neuron-specific endophilin-B1 isoforms protected against amyloid-β-induced apoptosis and mitochondrial dysfunction. Additionally, protein and mRNA levels of neuron-specific endophilin-B1 isoforms were also selectively decreased in the cerebral cortex and in the synaptic compartment of patients with Alzheimer's disease. Flow sorting of synaptosomes from patients with Alzheimer's disease demonstrated a negative correlation between amyloid-β and endophilin-B1 levels. The importance of endophilin-B1 in neuronal function was further underscored by the development of synaptic degeneration and cognitive and motor impairment in endophilin-B1(-/-) mice by 12 months. Our findings suggest that endophilin-B1 is a key mediator of a feed-forward mechanism of Alzheimer's disease pathogenesis where amyloid-β reduces neuron-specific endophilin-B1, which in turn enhances amyloid-β accumulation and neuronal vulnerability to stress.
Anytime active learning

A common bottleneck in deploying supervised learning systems is collecting human-annotated examples. In many domains, annotators form an opinion about the label of an example incrementally--e.g., each additional word read from a document or each additional minute spent inspecting a video helps inform the annotation. In this paper, we investigate whether we can train learning systems more efficiently by requesting an annotation before inspection is fully complete--e.g., after reading only 25 words of a document. While doing so may reduce the overall annotation time, it also introduces the risk that the annotator might not be able to provide a label if interrupted too early. We propose an anytime active learning approach that optimizes the annotation time and response rate simultaneously. We conduct user studies on two document classification datasets and develop simulated annotators that mimic the users. Our simulated experiments show that anytime active learning outperforms several baselines on these two datasets. For example, with an annotation budget of one hour, training a classifier by annotating the first 25 words of each document reduces classification error by 17% over annotating the first 100 words of each document.
Adenylate Kinase Release as a High-Throughput-Screening-Compatible Reporter of Bacterial Lysis for Identification of Antibacterial Agents

Adenylate kinase (AK) is a ubiquitous intracellular enzyme that is released into the extracellular space upon cell lysis. We have shown that AK release serves as a useful reporter of bactericidal agent activity and can be exploited for antimicrobial screening purposes. The AK assay exhibits improved sensitivity over that of growth-based assays and can detect agents that are active against bacteria in clinically relevant growth states that are difficult to screen using conventional approaches, such as small colony variants (SCV) and bacteria within established biofilms. The usefulness of the AK assay was validated by screening a library of off-patent drugs for agents that exhibit antimicrobial properties toward a variety of bacterial species, including Escherichia coli and all members of the "ESKAPE" pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). The assay detected antibiotics within the library that were expected to be active against the organism screened. Moreover, 38 drugs with no previously reported antibacterial activity elicited AK release. Four of these were acquired, and all were verified to exhibit antimicrobial activity by standard susceptibility testing. Two of these molecules were further characterized. The antihistamine, terfenadine, was active against S. aureus planktonic, SCV population, and biofilm-associated cells. Tamoxifen, an estrogen receptor antagonist, was active toward E. faecium in vitro and also reduced E. faecium pathogenesis in a Galleria mellonella infection model. Our data demonstrate that the AK assay provides an attractive screening approach for identifying new antimicrobial agents. Further, terfenadine and tamoxifen may represent novel antimicrobial drug development scaffolds.
Novel tests of quantum chromodynamics in electroproduction

We discuss a number of ways in which single arm and coincident measurements of electroproduction on proton and nuclear targets can test fundamental QCD phenomena and provide constraints on hadronic wavefunctions. The topics include tests of color transparency, predictions for charm production at threshold, formation zone phenomena, and non-additive nuclear effects. We particularly emphasize the need for measurements which probe the short-range structure of hadronic and nuclear wave functions. In addition to the “extrinsic” gluonic and sea-quark contributions associated with radiation from single partons, perturbative QCD predicts an “intrinsic” hardness of the high-mass fluctuations of the wave function. These contributions can dominate heavy particle production at large z in the target fragmentation region and can be further enhanced in nuclear target reactions. Intrinsic hardness can also provide a possible explanation of the anomalous nuclear phenomena referred to as “cumulative production”.
Epidemiology of Basketball, Soccer, and Volleyball Injuries in Middle-School Female Athletes

Background An estimated 30 to 40 million school children participate in sports in the United States; 34% of middle-school participants become injured and seek medical treatment at an annual cost close to $2 billion. The purpose of the current study was to evaluate the injury incidence and rates in female athletes in the middle-school setting during the course of 3 seasons. Methods Female basketball, soccer, and volleyball players were recruited from a single county public school district in Kentucky consisting of 5 middle schools. A total of 268 female athletes (162 basketball, 26 soccer, and 80 volleyball) participated. Athletes were monitored for sports-related injury and number of athlete exposures (AEs) by an athletic trainer. Injury rates were calculated for specific types of injuries within each sport. Injury rates for games and practices were also calculated and compared for each sport. Results A total of 134 injuries were recorded during the 3 sport seasons. The knee was the most commonly injured body part (99 injuries [73.9%]), of which patellofemoral dysfunction (31.3%), Osgood-Schlatter disease (10.4%), and Sinding-Larsen-Johansson/patella tendinosis (9%) had the greatest incidence. The ankle was the second most commonly injured body part, accounting for 16.4% of all injuries. The overall rates of injury by sport were as follows: soccer, 6.66 per 1000 AEs; volleyball, 3.68 per 1000 AEs; and basketball, 2.86 per 1000 AEs. Conclusions Female middle-school athletes displayed comparable injury patterns to those seen in their high-school counterparts. Future work is warranted to determine the potential for improved outcomes in female middle-school athletes with access to athletic training services. Clinical relevance As the participation levels and number of injuries continue to rise, middle-school athletes demonstrate an increasing need for medical services provided by a certified athletic trainer.
Does the Public Intellectual Have Intellectual Integrity

This article is concerned with the devaluation of the work of public intellectuals within the academic community. The principal reason given for this devaluation is that the work of the public intellectual does not have intellectual integrity as independent thought and original scholarship. I develop three models of public intellectual work: the permanent-critic model, the popularizer model, and the public-theorist model. I then consider each model in relation to the concern with intellectual integrity and conclude that both independent thought and original scholarship are possible within work that is engaged with nonacademic publics.
CORRELATIONS BETWEEN SHEAR WAVE VELOCITY AND CONE TIP RESISTANCE IN NATURAL CLAYS

ABSTRACT Empirical correlations for estimating the shear wave velocity (Vs) from cone penetration tip resistance (qc) are derived from measured field data taken in 31 different natural clays. Despite the fact that Vs and qc are operational at the opposite extremes of a highly nonlinear stress-strain-strength relationship, the two parameters can be interrelated because they are both influenced by effective confining stress level, anisotropic Xo-stress state, mineralogy, aging, bonding, and other factors. Regression analyses indicate that the estimate is significantly improved if measurements of void ratio (e0) with depth are also known, resulting in an expression that relates Vs to both qc and e0. Results are applied to an independent recent case study involving a sensitive marine clay where the relevant parameters are well documented.
Prevalence and risk factors for homelessness and utilization of mental health services among 10,340 patients with serious mental illness in a large public mental health system

OBJECTIVE: The authors examined the prevalence of and risk factors for homelessness among all patients treated for serious mental illnesses in a large public mental health system in a 1-year period. The use of public mental health services among homeless persons was also examined. METHOD: The study included 10,340 persons treated for schizophrenia, bipolar disorder, or major depression in the San Diego County Adult Mental Health Services over a 1-year period (1999–2000). Analytic methods that adjusted for potentially confounding variables were used. Multivariate logistic regression analyses were used to calculate odds ratios for the factors associated with homelessness, including age, gender, ethnicity, substance use disorder, Medicaid insurance, psychiatric diagnosis, and level of functioning. Similarly, odds ratios were computed for utilization of mental health services by homeless versus not-homeless patients. RESULTS: The prevalence of homelessness was 15%. Homelessness was associated with male gender...
Vetting and Letting: Cohabiting Stepfamily Formation Processes in Low‐Income Black Families

The authors examined cohabiting union formation processes by analyzing in-depth interview data collected from 30 individuals in cohabiting relationships: 15 low-income Black mothers of adolescents and their partners. Prior research suggests that cohabiting union formation is a gradual, nondeliberative process. In contrast, most couples in this study described a gradual but highly deliberative process. Mothers focused primarily on vetting their partners to ensure child well-being and less on when and how their partners officially came to live with them, a process the authors call vetting and letting. Mothers delineated 4 strategies to ensure their child's well-being when vetting their partners, and their partners reported that they understood the importance of participating in this process. The authors argue that vetting and letting is a child-centered family formation process, not a partner-centered union formation process, and that cohabiting union processes may vary substantially by subpopulation.
Inverse barotropic tidal estimation for regional ocean applications

Correct representation of tidal processes in regional ocean models is contingent on the accurate specification of open boundary conditions. This paper describes a new inverse scheme for the assimilation of observational data into a depth-integrated spectral shallow water tidal model and the numerical implementation of this scheme into a stand-alone computational system for regional tidal prediction. A novel aspect is a specific implementation of the inverse which does not require an adjoint model. An optimization is carried out in the open boundary condition space rather than in the observational space or model state space. Our approach reflects the specifics of regional tidal modeling applications in which open boundary conditions (OBCs) typically constitute a significant source of uncertainty. Regional tidal models rely predominantly on global tidal estimates for open boundary conditions. As the resolution of global tidal models is insufficient to fully resolve regional topographic and coastal features, the a priori OBC estimates potentially contain an error. It is, therefore, desirable to correct these OBCs by finding an inverse OBC estimate that is fitted to the regional observations, in accord with the regional dynamics and respective error estimates. The data assimilation strategy presented in this paper provides a consistent and practical estimation scheme for littoral ocean science and applications where tidal effects are significant. Illustrations of our methodological and computational results are presented in the area of Dabob Bay and Hood Canal, WA, which is a region connected to the open Pacific ocean through a series of inland waterways and complex shorelines and bathymetry.
A Pilot Study of a Distress Tolerance Treatment for Opiate-Dependent Patients Initiating Buprenorphine Rationale, Methodology, and Outcomes

Buprenorphine, an opioid that is a long-acting partial opiate agonist, is an efficacious treatment for opiate dependence that is growing in popularity. Nevertheless, evidence suggests that many patients will lapse within the first week of treatment and that lapses are often associated with withdrawal-related or emotional distress. Recent research suggests that individuals' reactions to this distress may represent an important treatment target. In the current study, we describe the development and outcomes from a preliminary pilot evaluation (N = 5) of a novel distress tolerance (DT) treatment for individuals initiating buprenorphine. This treatment incorporates exposure-based and acceptance-based treatment approaches that we have previously applied to the treatment of tobacco dependence. Results from this pilot study establish the feasibility and acceptability of this approach. We are now conducting a randomized controlled trial of this treatment that we hope will yield clinically significant findings and offer clinicians an efficacious behavioral treatment to complement the effects of buprenorphine.
Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV/AIDS

CD8 + cytotoxic T lymphocyte (CTL) responses are crucial in establishing the control of persistent virus infections. Population studies of HIV-1-infected individuals suggest that CD8 + CTL responses targeting epitopes that take the greatest toll on virus replication are instrumental in immune control. A major question for vaccine design is whether incorporating epitopes responsible for controlling a persistent virus will translate into protection from natural infection or serve solely as a fail-safe mechanism to prevent overt disease in infected individuals. Here, we discuss qualitative parameters of the CD8 + CTL response and mechanisms operative in the control of persistent virus infections and suggest new strategies for design and delivery of HIV vaccines.
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly

Activins and bone morphogenetic proteins (BMPs) elicit diverse biological responses by signaling through two pairs of structurally related type I and type II receptors. Here we report the crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor. Our structure produces a compelling four-receptor model, revealing that the types I and II receptor ECDs make no direct contacts. Nevertheless, we find that truncated receptors lacking their cytoplasmic domain retain the ability to cooperatively assemble in the cell membrane. Also, the affinity of BMP7 for its low-affinity type I receptor ECD increases 5-fold in the presence of its type II receptor ECD. Taken together, our results provide a view of the ligand-mediated cooperative assembly of BMP and activin receptors that does not rely on receptor-receptor contacts.
ASPECT. Methodology for inferential sensing and assessment of quality control

ASPECT (Advanced Statistical Process Estimation and Control Technology) was developed by DuPont as a prototype to help better understand the application of inferential sensing and how it applies to "quality" control. ASPECT is: (i) An application methodology that provides a structured approach to the problem of quality control. (ii) Software tools developed in support of that methodology. ASPECT helps plant engineers evaluate the merits of various quality control approaches. It also provides a means to quantify and understand the opportunity for moving from one level of quality control to the next. The ASPECT software is a complete, simple to use, integrated environment for data gathering, empirical modeling and inferential sensing applications. This short presentation will discuss ASPECT's role in evaluating alternative approaches to quality control approaches and will cover ASPECT's capabilities with respect to inferential sensing. It will briefly cover several application of ASPECT in support process analytical applications.
The syntax/semantics interface: compositionality issues

This paper explores the hypothesis of Direct Compositionality, which is the hypothesis that natural language syntax and semantics work in tandem. The syntax is a system proving expressions well-formed (often proving larger expressions well-formed on the basis of their smaller constituent parts) while the semantics works directly with this to supply a model theoretic interpretation to each expression as it is built in the syntax. The paper considers a few apparent challenges to this hypothesis, and exposits the types of tools which have been used in order to meet these challenges. We begin with some classic results from Montague [1]; turn to extensions of this program that were explored in subsequent work, and end with some recent work of the present author. The goal is to show that many of the apparent challenges can easily be met by simply viewing meanings as slightly more complex packagings than an initial naive view would have it; the tools for accomplishing this themselves are quite simple.
A Positive Feedback Action of Androgen on Pituitary Follicle Stimulating Hormone: Induction of a Cyclic Phenomenon

Temporal changes in endogenous follicle stimulating hormone (FSH) following a single injection of testosterone propionate (TP) or estradiol benzoate were investigated in immature female rats. Circulating FSH level was evaluated directly in the experimental animals by a modified augmented ovarian weight method. Human chorionic gonadotropin was administered at various times after the steroid injection at 22 days of age, and the resulting ovarian weight recorded as an index of their endogenous FSH. The 2 doses of TP used (25 and 100 μg) induced cyclic increases in FSH whichwere spaced approximately 24 hr apart. Alternating with the peaks in FSH activity were troughs with no more FSH than in oil-treated controls. The low dose induced 3 distinct cycles, while the larger dose induced 4. On the basis of this and previous studies, we conclude that TP induced an increased synthesis and matched release of FSH, both occurring at regular intervals. Estradiol benzoate (1 μg) caused one large and extended increase in e...
Evaluating the Archer-Shaw Social Security Proposal

Social Security emerged as one of the biggest policy differences between the Democratic and Republican nominees for president in 2000 - although both candidates outlined only general ideas on Social Security reform and did not advance any specific proposals. Al Gore's position was that the normal retirement age should not be raised, and the present system should be preserved. In contrast, George W. Bush voiced support for the establishment of individual accounts, using a portion of the existing payroll taxes to fund these accounts (the so-called "carve-out" approach), and said he will use "political capital" to achieve this reform. This Notes article examines the Archer-Shaw 1999 proposal using the EBRI-SSASIM2 Policy Simulation Model. The PDF for the above title, published in the June 2000 issue of EBRI Notes, also contains the fulltext of another June 2000 EBRI Notes article abstracted on SSRN: "Value of Benefits Constant in a Changing Job Environment: The 1999 WorldatWork/EBRI Value of Benefits Survey."
Selective enterotoxin production by a Staphylococcus aureus strain implicated in a foodborne outbreak

More than 80 of 230 participants (>34.7%) at a literary conference became ill with acute gastroenteritis 3 to 14 h after a catered meal. Attack rate data implicated cheese tortellini as the suspect food (p=0.0087). Selective plating of partially prepared and finished tortellini produced Staphylcoccus aureus counts of 6.0 × 107 and 1.0 × 106 CFU per gram, respectively. Enterotoxin, phage typing, antibiotic sensitivity testing, and other biotyping studies were applied to S. aureus isolates from the suspect food and the single food-handler involved. All isolates reacted identically by all criteria, and each isolate produced both type A and C staphylococcal enterotoxins. Type A enterotoxin (0.90 ug/100 g) alone was detected in samples of the suspect food. The production of type C enterotoxin by the outbreak strain was delayed approximately 4 h relative to production of enterotoxin A when grown in Heart Infusion broth (pH 5.5). This study serves as an example of selective enterotoxin production by S. aureus in suspect foods which can be misleading to outbreak investigators.
Evaluation of the Impact of H2O, O2, and SO2 on Postcombustion CO2 Capture in Metal–Organic Frameworks

Molecular modeling methods are used to estimate the influence of impurity species: water, O2, and SO2 in flue gas mixtures present in postcombustion CO2 capture using a metal organic framework, HKUST-1, as a model sorbent material. Coordinated and uncoordinated water effects on CO2 capture are analyzed. Increase of CO2 adsorption is observed for both cases, which can be attributed to the enhanced binding energy between CO2 and HKUST-1 due to the introduction of a small amount of water. Density functional theory calculations indicate that the binding energy between CO2 and HKUST-1 with coordinated water is ∼1 kcal/mol higher than that without coordinated water. It is found that the improvement of CO2/N2 selectivity induced by coordinated water may mainly be attributed to the increased CO2 adsorption on the hydrated HKUST-1. On the other hand, the enhanced selectivity induced by uncoordinated water in the flue gas mixture can be explained on the basis of the competition of adsorption sites between water and...
Continued development of the one-way Euler equations: application to jets

An efficient method for calculating linearized disturbances to shear flows that accurately captures their acoustic radiation was recently introduced (Towne & Colonius, AIAA Paper 2013-2171, 2013). The linearized Euler equations are modified such that all upstream propagating acoustic modes are removed from the operator. The resulting equations, called one-way Euler equations, can be stably and efficiently solved in the frequency domain as a spatial initial value problem in which initial perturbations are specified at the flow inlet and propagated downstream by integration of the equations. In this paper, we continue the development of this method with the aim of using it to model wavepackets and their acoustic radiation in turbulent jets. Before turning attention to jets, two dimensional mixing layer noise results computed using the one-way Euler equations are shown to be in excellent agreement with a direct solution of the full Euler equations. The one-way Euler operator is then shown to accurately represent all downstream modes that exist in supersonic and subsonic parallel jets, while properly eliminating the upstream acoustic modes. Finally, the method is applied to a turbulent Mach 0.5 jet mean flow obtained from experimental measurements. The near-field one-way Euler results are similar to those obtained using a previous spatial marching technique called the parabolized stability equations. However, the one-way Euler solutions also include the acoustic fields. With further development, the results suggest that the one-way Euler equation could be used to obtain improved accuracy over the parabolized stability equations as a low-order jet noise model.
Interleukin-17 in Drug Toxicity

Drug-induced tissue injury is the most common cause for termination of preclinical and clinical trial processes of drug development. Many drugs approved for clinical use have been withdrawn from market or have been advised to use with caution because of unexpected adverse effects noticed during postmarketing survelliance. Based on their relative importance in human health, some pharmaceuticals with relatively less drug toxicity, such as tolrestat, lumiracoxib and arotinin, have been approved in certain countries for use in patients, but not worldwide. Moreover, the surge in new drugs for human use has also increased the morbidity and mortality associated with adverse drug reactions. Although, over the years, investigative toxicology studies have unraveled mechanisms behind adverse drug reactions, the underlying pathogenesis of many drug toxicities are still unknown. Immune cells and inflammation have been attributed to majority of toxic effects of chemicals and drugs. The immune system may either be protective or detrimental to the host. For example, in cisplatin-induced kidney injury, dendritic cells, T regulatory cells and IL-10 attenuate, whereas T cells, NK cells and IL-17 aggravate nephrotoxicity [1,2]. Recently, interleukin-17 research has gained much importance as a drug target for autoimmune and inflammatory diseases.
Wage indexation, openness and inflation uncertainty. The case of Italy

This article uses annual data of the Italian economy to test the validity of the hypotheses of Friedman (1977) and Aizenman (1985) that the level of inflation uncertainty and the degree of openness of an economy have positive effects on the level of wage indexation. It was found that the estimated wage indexation equation supports the validity of the Aizenman hypothesis that the degree of openness of an economy has positive effects on the level of wage indexation. On the other hand, the regression of the wage indexation equation does not generally support the validity of the Friedman hypothesis that the level of inflation uncertainty has positive effects on the level of wage indexation
Protease inhibitor combination therapy and decreased condom use among gay men.

Background. The objective of the study was to determine whether treatment with protease inhibitors is associated with unprotected sexual behavior. Methods. A total of 592 HIV-infected persons recruited from statewide public clinics in nonurban Alabama communities completed an assessment that, among other variables, clicited information on demographics, current sexual practices, health status, and medication use. Associations of treatment with protease inhibitors and high-risk sexual behavior were estimated, adjusting for potential confounders. Results. Treatment with protease inhibitors was not associated with whether a person was sexually active or with high-risk practices among sexually active heterosexual men and women. Among men who had sex with men, however, treatment with protease inhibitors was associated with never using condoms and with inconsistent use of condoms. Conclusions. Clinicians treating patients with protease inhibitors should consider providing risk-reduction counseling.
Therapist anger in group psychotherapy

Countertransference anger serves as a defense against the experience of shame, which occurs when therapists fail to live up to jointly created idealized expectations. The author describes ways of changing these expectations in order to reduce the transference-countertransference resonance, which is based on narcissistic needs. The author distinguishes countertransference anger (which should not be disclosed to group members) from realistic therapist anger, which has therapeutic value. Realistic anger can be used as a therapeutic tool to dispel distortions, provide an interpersonal connection, help members trust the reality of the situation, and provide a balance of good and bad between the members and therapists.
THE SOUTHERN SOCIETY IN RETROSPECT: AN ABBREVIATED HISTORY OF THE FIRST SIXTY YEARS OF THE SOUTHERN SOCIETY FOR PHILOSOPHY AND PSYCHOLOGY, 1904-1964.

A short history is presented of the oldest of the regional psychological societies in the United States. The Southern Society for Philosophy and Psychology was founded in 1904 and is celebrating its diamond-jubilee year during 1964. “The Southern Society is the symbol of a conviction, grounded in the history of inquiry, that special and vital relations exist between philosophic reflection and psychological science.” The Society devotes its principal energies “to providing a platform and a congenial convention atmosphere for the academic-experimental-theoretical aspects” of psychology and philosophy.
Nutrient and Enzyme Deficiencies

Small intestinal bacterial overgrowth (SIBO) is a condition where an excess number of native and nonnative gut bacteria cause symptoms due to increased fermentation, inflammation, or malabsorption. This and other malabsorptive and nutritional deficiencies are also covered here including pancreatic insufficiency, vitamin B12 deficiency, lactase deficiency, and lysosomal acid lipase deficiency (LAL-D).
How to Make Distinct Dynamical Systems Appear Spectrally Identical.

Calculations show that a carefully engineered laser pulse can induce an atom to emit light as if it were a different atom.
Infrared control

Recently, it has been demonstrated that infrared light can activate (e.g., optical pacing) or inhibit action potentials without the need of exogenous agents. Here, we will describe some of the latest developments and applications.
ANALISA TINGKAT KEPUASAN NASABAH ATAS PELAYANAN JASA KEUANGAN PERDAGANGAN BERJANGKA PT. “X FUTURES”

Various types of services the company provides to customers either already regulated by law and that the company incentive to provide the best services to customers to improve satisfaction. In the author's purpose to analyze the level of customer satisfaction PT. X Future of the financial services of the company to test the multiple linear regression analysis using the data in the form of questionnaires to 30 (thirty) the customer. Based on the results of the discussion conducted by meode linear regression can be obtained the first result; There is a relationship between the services provided by the company to the Customer satisfaction level of 0961, where the better the service, the higher the level of Customer satisfaction is concerned because of the relationships formed between two (2) is a strong indicator, second; There is the influence of the service provided by the company to the Customer satisfaction level of 0961, where the quality of service provided greatly affect the level of satisfaction of the Customer due to the effect of which is formed between two (2) is a strong indicator and third; that the form of relevant and significant linear equation between the level of service to the Customer satisfaction level with the line equation y = -6.188 + 1,149x Keywords: Service , Customer Satisfaction
But Is It Statistically Significant?: Statistical Significance in IR Research, 1995-2014

We analyze 5,792 IR conference papers published over 20 years to investigate how researchers have used and are using statistical significance testing in their experiments
Influence of Lubricating and Nonlubricating Fluids on the Stress Distribution and Surface Deformation in Sliding Contacts in the Absence of Hydrodynamic Effects

Abstract The morphology of wear and the coefficient of friction were examined for steel in the regime of boundary lubrication. Three conditions of lubrication were investigated: dry contact in laboratory air, lubricated contact with pure n-hexadecane and lubrication with a saturated solution of palmitic acid in n-hexadecane. in dry sliding the coefficient of friction (μ) is 0.45 and wear initially takes the form of form of heavy surface fissuring while in the presence of the palmitic acid solution μ is 0.12 and the wear path is burnished and almost crack free. By contrast, the n-hexadecane experiments showed similar wear to that palmitic acid solution, but the friction coefficient reached as high as 0.75. in the two liquid media wear occurs by the translation of elongated, thin plates parallel to the surface. It is concluded that the action of pure n-hexadecane is to redistribute part of the normal and shear loads to regions between those of metallic conjunction. This redistribution of stress prevents the occurrence of stress reversal fatigue and leads to reduced wear even when the friction coefficient is high.
Genome-Scale ORF Screen for Mediators of NF-κb Activation in DLBCL

Abstract Cancer genome and transcriptome sequencing can identify novel oncogenes and tumor suppressors, discover distinct cancer subtypes, and predict therapeutic responses. Analysis of the coding genome of diffuse large B cell lymphoma (DLBCL) has identified various genetic mutations in the ABC and GCB molecular subtypes. Notably, ABC DLBCLs have recurrent activating mutations involving the canonical NF-kB pathway. Although an oncogenic role for constitutive NF-kB activity has been demonstrated in ABC DLBCL, the molecular mechanisms of various oncogenic mutations are still elusive. To understand the pathogenesis of DLBCL, we used high-throughput exome and transcriptome sequencing of more than 500 DLBCL biopsies. To enable functional screening of mutant alleles identified by exome-seq and RNA-seq, we are constructing an inducible retroviral expression library of over 200 open reading frames (ORFs) of genes mutated in DLBCL. We have cloned the mutant and wildtype forms of these genes together with a unique 26-base-pair 'bar code' to facilitate screening with high-throughput sequencing. We have transduced a subset of this ORF library into DLBCL cell lines, induced ORF expression by doxycycline, and FACS sorted into high and low populations based on expression the known NF-κB target gene CD83. We then performed barcode sequencing to assay relative enrichment of ORFs that confer higher or lower NF-κB activity. ORF screening revealed that MYD88L265P, CARD11L232LI, both well-characterized gain-of-function mutants, were among the highest ranking genes for induction of NF-κB activity. Interestingly, we observed enrichment for USP7D271E in NF-κB high populations, though these genes have not been shown to have a tumorigenic role in DLBCL. Ubiquitin Specific Protease-7 (USP7) is a regulator of NF-κB transcriptional activity, in part by de-ubiquitinating p65. To test how USP7 mutations contribute to NF-κB activity, we engineered the ABC DLBCL cell line TMD8 to express an NF-κB reporter consisting of the NF-κB transcriptional response element (TRE) fused to GFP. NF-κB activity upon overexpression of wildtype or mutant USP7 was monitored by flow cytometry (FACS). We observed that the mutated form of USP7 significantly increased NF-κB activity over that seen with wildtype, suggesting this is a gain-of-function mutant. We next used the CRISPR gene-targeting system to probe the function of USP7 genetically. Single guide RNAs (sgRNAs) targeting the USP7 coding regions were coexpressed in TMD8 cells with the endonuclease Cas9. SgRNA-expressing, GFP+ cells were monitored over time among total live cells by flow cytometry, and a relative reduction of the GFP+ population was observed in the sgUSP7 population. These results suggest that USP7 may function as an oncogene in DLBCL. This ongoing work demonstrates the efficacy of a high-throughput ORF expression screen to characterize mutations found in the genomic landscape of the DLBCL. Disclosures No relevant conflicts of interest to declare.
On the formation of potential polymer-nanotube blends by liquid-solid phase separation

Abstract In this work, the fundamental issue of dispersing carbon nanotubes (CNTs) within a polymer matrix is addressed by studying a non-solvent induced liquid-solid phase separation process in polyacrylonitrile/CNT composite systems. To visualize the effect of phase separation, hybrid polymer/CNT buckypapers were formed through filtration. The hybrid film morphology gradually changes from a CNT-rich to a polymer-rich layer. Examination of the layered structure reveals CNTs with specific bundle size were uniformly dispersed within the polymer-rich layer due to preferred polymer-CNT interaction during phase separation. Experimental, theoretical, and molecular dynamics studies were performed to show the fundamental mechanism behind layer formation in the composites and to understand the specificity of preferential polymer-CNT interactions. To this end, a geometric dependence described by a ‘cylinder-in-sphere’ model was established and shows a link between the critical CNT bundle size and polymer radius of gyration, which dictates preferential polymer-CNT interactions. This model represents the interactive relationship required to form a blended polymer-CNT phase in the system under the phase separation conditions used. Understanding the use of phase separation as well as this geometrical dependence between filler and polymer is important to pinpoint nano-filler dispersion limits. Identifying these limits is critical toward the processing of superior polymer-based composites which fully utilizes the nano-filler reinforcement.
Applying video summarization to aerial surveillance

The US increasingly relies on surveillance video to determine when activities of interest occur in a surveilled location. The growth in video volume places a difficult burden on the analyst workforce charged with evaluating streaming video or performing forensic analysis on archived video. This paper presents a video summarization pipeline that attempts to reduce the volume of video analysts must watch by summarizing the video into shorter, presumably important clips. The pipeline incorporates object recognition and tracking to generate clips composed of bounding boxes for objects across time, segments these clips into unique trajectories, trains a stacked sparse autoencoder, then generates a summary based on reconstruction error within the autoencoder, where high error indicates a unique (relative to previous) object trajectory. The paper then compares performance of the summarization pipeline applied to research datasets to performance on more realistic DoD surveillance datasets.
How to make effective steps in research and design

What is the nexus or connecting point between research and design in education Why should we balance the use of educational programs interventions and practices on the research of whether not such tasks are effective Why not just do things the way quot we have always been doing them quot instead of pioneering in testing a new method or point of delivery These are some questions to focus on in the foregoing article Also a healthy foundation for research is needed to balance this understanding Over the last years I rsquo ve conducted over a dozen large and small scale research projects along with ad hoc research involving as many as several million records and as few as a handful of survey respondents This has included student assessment results high school dropout factors GED school reentry reasons and plenty of surveys conducted to evaluate programs of various types In each research project whether vast or tiny in scale the same principles have served as guidance While parts of these lessons learned were refined across the course each of these projects this article intends to share cumulative insights about research in straightforward way You the reader will learn about how to effectively engage in educational research
Estrogen: a novel therapeutic adjunct for the treatment of trauma-hemorrhage-induced immunological alterations.

Trauma-hemorrhage leads to prolonged immune suppression, sepsis, and multiple organ failure. The condition affects all compartments of the immune system, and extensive studies have been carried out elucidating the immunological events following trauma-hemorrhage. The immune alteration observed following trauma-hemorrhage is gender dependent in both animal models and humans, though some studies in humans are contradictory. Within 30 min after trauma-hemorrhage, splenic and peritoneal macrophages, as well as T-cell function, are depressed in male animals, but not in proestrus females. Studies have also shown that the survival rate and the induction of subsequent sepsis following trauma-hemorrhage are significantly higher in males and ovariectomized females compared with proestrus females. These and other investigations show that sex hormones form the basis of this gender dichotomy, and administration of estrogen can ameliorate the immune depression and increase the survival rate after trauma-hemorrhage. This review specifically elaborates the studies carried out thus far demonstrating immunological alteration after trauma-hemorrhage and its modulation by estrogen. Also, estrogen was shown to produce its salutary effects through nuclear as well as extranuclear receptors. Estrogen rapidly activates several protein kinases and phosphatases, as well as the release of calcium in different cell types. The results of the studies exemplify the promise of estrogen as a therapeutic adjunct in treating adverse pathophysiological conditions following trauma-hemorrhage.
Defining Marijuana Tourism

The purpose of this study was to develop a better understanding of the niche market of marijuana tourists that has emerged since states began legalizing recreational marijuana in 2014. Existing lit...
Autonomic nerves and circadian control of renal function

Cardiovascular and renal physiology follow strong circadian rhythms. For instance, renal excretion of solutes and water is higher during the active period compared to the inactive period, and blood pressure peaks early in the beginning of the active period of both diurnal and nocturnal animals. The control of these rhythms is largely dependent on the expression of clock genes both in the central nervous system and within peripheral organs themselves. Although it is understood that the central and peripheral clocks interact and communicate, few studies have explored the specific mechanism by which various organ systems within the body are coordinated to control physiological processes. The renal sympathetic nervous innervation has long been known to have profound effects on renal function, and because the sympathetic nervous system follows strong circadian rhythms, it is likely that autonomic control of the kidney plays an integral role in modulating renal circadian function. This review highlights studies that provide insight into this interaction, discusses areas lacking clarity, and suggests the potential for future work to explore the role of renal autonomics in areas such as blood pressure control and chronic kidney disease.
CVExplorer: Multidimensional Visualization for Common Vulnerabilities and Exposures

Cyber attacks cause great damage to our national security, ranging from individual internet user to biggest governmental/industrial organizations, such as Equifax (Data Breach 145.5 Million Accounts, reported in July 2017) or Uber (Data Breach 57 Million Records, reported in November 2017). The cyber assault has significantly increased in breadth and depth. This paper introduces CVExplorer, a novel interactive system for visualizing cybersecurity threats reported in the National Vulnerability Database. The proposed system aims to work as a reporting and alerting tool that can help enhance the security against cyber attacks can potentially reduce network vulnerabilities. The CVExplorer system containing multiple linked views allows users to visualize the relationships of various dimensions in the large number of vulnerability reports, such as types and levels of vulnerability, vendors, and products. The CVExplorer provides an intuitive interface and supports a range of interactive features, such as filtering and ordering by vulnerability severity ratings, allowing users to narrow down topics of interest quickly. To demonstrate the effectiveness of the proposed system, we demonstrate the CVExplorer on two case studies of Common Vulnerabilities and Exposures retrieved from the National Vulnerability Database.
Comments and Feedback

Will PiLAS be indexed in Medline/PubMed? Also, it looks as if all the articles in PiLAS are just reprints of articles in ATLA — is that going to be typical or is the hope that different articles wi...