cssi/SciSciGPT-SciSciNet huggingface dataset:
A technological approach to reaching a hidden population of problem drinkers.

Objective: The most common obstacle to the treatment of individuals with drinking problems is that most do not seek treatment. This study compared a group of treatment-seeking patients with users of an alcoholevaluation Web site to determine whether an Internet application could reach a population of problem drinkers who are distinct from those served by currently available forms of care. Methods: An open-source application was developed that was modeled on the Drinker’s Check-Up, which has been shown to increase motivation for behavior change while presenting itself as a nonthreatening evaluation. To recruit non–treatment seekers, the program was offered as a way to increase understanding of the effects of alcohol, rather than as a way to initiate change. Results: Most of the 1,060 Internet study participants had serious alcoholrelated pathology, although the pathology was less than that found in the treatment-seeking comparison group of 952 patients. Members of the online group were younger, and a larger proportion was female and employed. Online users had lower levels of problem recognition than did persons in the comparison group, according to the recognition subscale of the Stages of Change Readiness and Treatment Eagerness Scale. The ranked scores of the comparison group were divided into ten equal parts, and the online group’s average was in the lowest decile. Online users were also less likely to take steps to change their drinking behavior and were in the lowest decile on the taking steps subscale in relation to the comparison group. The level of concern about the possibility of harm from alcohol use was comparable in both groups. Conclusions: Problem drinkers who do not use available forms of treatment will engage with an interactive Web site. Despite low levels of illness recognition, significant concern among the online group about their alcohol use indicates a potential role for an Internet application designed to increase motivation for change. (Psychiatric Services 59:297–303, 2008)
Implantation of autologous tissue fragments in velour fabric used to line cardiovascular prostheses: An in vivo culture system to produce cellular blood–prosthesis interfaces

Previous observations of pseudointimal organization within impermeable cardiovascular prostheses indicated that rapid spontaneous healing was dependent upon proximity of host vascular tissue at the suture line. Autologous connective tissue fragments were prepared from skeletal muscle biopsies by blender-mincing muscle tissue. The fragments were embedded in the fabric used to line the inner wall of arterial prostheses. A tightly fitting piston was drawn through the prosthesis, forcing the suspended tissue fragments to flow around the piston and become entwined in the loops of the velour fabric. The arterial prostheses prepared in this way were inserted as replacements for segments of canine abdominal aorta. This in vivo culture system supported cellular proliferation and pseudointimas healed uniformly. Pseudointimas of paracorporeal pumps in operation for as long as 5 weeks did not show signs of healing. The same principle of filtration of tissue fragments into a lining fabric was applied to diaphragms of left ventricular bypass pumps. This type of paracorporeal pump supported in vivo culture of implanted fragments.
Amazonia: From Myth to History

Blanca Muratorio The Life and Times of Grandfather Alonso: Culture and History in the Upper Amazon. New Brunswick, NJ: Rutgers University Press, 1991. 295 pp. Eduardo Viveiros de Castro From the Enemy's Point of View: Humanity and Divinity in an Amazonian Society. Catherine V. Howard, trans. Chicago: University of Chicago Press, 1992, 428 pp.
Rotorcraft shipboard flight test analytic options

Flight testing is required to determine the aircraft suitability for both land and ship-based mission scenarios. Classical test pilot techniques are used to evaluate the air vehicle in a land-based environment using highly instrumented vehicles. Shipboard testing may be performed at remote locations using uninstrumented fleet aircraft. The ship test must be scheduled far in advance, and the test location may be an area with a low probability of desired high ambient winds and sea state. This means the test may have to be repeated to generate a large enough operational envelope to support required mission applications. This also implies that each test component is a system and that in a systems approach to rotorcraft/ship testing it is very difficult to optimize all the system components. Work is ongoing to develop a virtual rotorcraft/ship test support capability. The system components in the virtual approach include the rotorcraft and ship models, the ship airwake and motion models, and the integration and validation of the systems and subsystems. In the virtual systems approach to rotorcraft/ship testing, parameter sensitivity studies can be readily performed on each system component. Considerable progress has been made in basic rotorcraft and ship airwake modeling, and in linear superposition integration of these model components. This work reviews the status of ongoing small business innovative research programs and internal science and technology programs to demonstrate virtual real-time and non-real time options to simulate the rotorcraft shipboard landing task. The paper also addresses ongoing work to develop an improved helicopter/ship deck landing analytic capability and discuss ongoing work to develop an enhanced visual landing aid personal computer test tool to help support future night time and/or low visibility shipboard testing. The requirement to develop a fully coupled aircraft/ship/airwake/motion model to better support future multi-rotorcraft shipboard testing in a virtual environment was also be discussed.
Thrombolysis to Treat Arterial Thrombotic Complications of Heparin-Induced Thrombocytopenia

An 80-year-old man with diabetes developed acute ischemia of the right leg secondary to heparin-induced thrombocytopenia while being treated for a pulmonary embolism. For fear of recurrent thrombosis at the operative site, he was treated with cessation of heparin, placement of a Greenfield filter, and intra-arterial infusion of urokinase into the popliteal artery for 36 hours. All arterial thrombus resolved with no complications. One week later he underwent a below-knee popliteal to anterior tibial artery translocated cephalic vein bypass and transmetatarsal amputation for progressive gangrene of the right toes. The graft remains patent 2 years later. This patient represents the eighth case reported in the world literature in which thrombolytic therapy was used to treat arterial thrombotic complications of heparin-induced thrombocytopenia. Five patients were successfully treated without complications, two others required major amputations, and one died of adrenal hemorrhage. Although thrombolytic therapy should be used cautiously for treatment of arterial thrombotic complications of heparin-induced thrombocytopenia, this adjunct may prove useful and safe in selected cases.
Management of non-ST-segment elevation acute coronary syndromes. Introduction.

While it was once believed that the primary physiological function of platelets was mediation of cellular hemostasis, it is now understood that activated platelets have a crucial role in the pathobiology of a variety of processes, including inflammation, leukocyte adhesion, progression of
UiO-66 MOF and Poly(vinyl cinnamate) Nanofiber Composite Membranes Synthesized by a Facile Three-Stage Process

Electrospun poly(vinyl cinnamate) (PVCi) nanofibers were cross-linked for varying times to study the impact it has on fiber stability at elevated temperatures and in dimethylformamide solutions. UiO-66 impregnated PVCi was cross-linked, and secondary growth of UiO-66 crystals was performed. The impact of temperature and number of growths was analyzed through powder X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopy. A membrane that underwent three growth cycles at 100 °C was further characterized for potential uses as a gas membrane through inert gas permeation studies and nitrogen porosimetry.
Role of copper in the regulation and accumulation of superoxide dismutase and metallothionein in rat liver.

Weanling male Sprague-Dawley rats were fed one of four diets that varied in Cu, Zn or Cd content. To the control diet (I) Cu, Zn and Cd were added at 10, 100 and 0 mg/kg diet, respectively. Diets II and III also contained 10 mg/kg of dietary Cu, except that Zn was elevated to 1000 mg/kg for diet II, or Cd was added at 10 mg/kg for diet III. Diet IV was deficient in Cu (less than 1 mg/kg) with Zn at 100 mg/kg and no added Cd. At wk 6 postweaning, half of the rats fed diets I and IV were injected once with Cd acetate (5 mg Cd/kg body weight). The immediate response to Cd injection was an increase in metallothionein accumulation (three- to fourfold) and in Cu,Zn superoxide dismutase (SOD) accumulation (1.2- to 1.5-fold) in liver. SOD was estimated in an ELISA. These responses were not influenced by a change in Cu status (I vs. IV). However, in functional assays, SOD enzymatic activity was about half that of the control values. In this regard, SOD appears to be given high priority with respect to the utilization of cellular Cu, i.e., a 10-fold reduction in hepatic Cu only resulted in a twofold reduction in SOD activity and the amount of apoenzyme remained at normal levels.
High-powered automobile stereos

We measured the owner-adjusted acoustic outputs of 10 automobile stereo systems, with power ratings ranging between 150 and 600 watts. The sound levels ranged from 107 to 138 dB SPL and 84 to 108 dBA. Most of the high-intensity sound was in the 31, 62, and 125 Hz center-frequency octave bands. The mean computed noise dose, based on the vehicle owners' reported daily duration of exposure, was 108.5%. While there is clearly a risk of hearing damage in the extreme cases according to OSHA standards, the typical listening durations claimed by the stereo owners would seem to lower the risk for the majority to acceptable margins for the automobiles measured.
The effects of feedback on human behavior in social media: an inverse reinforcement learning model

We introduce and validate a learning model of human behavior change in response to feedback on social media. People who participate in these types of websites, like Wikipedia, Reddit, and others, are learning agents whose choices about how to allocate their effort are dynamic and responsive to how they feel their efforts were received in the past. By explicitly taking into account the reinforcement effects of different types of feedback received on prior contributions, our model is able to significantly outperform all known baselines in predicting future contributions both on synthetic data and on real data collected from the social news site reddit.com. Our model has an intuitive interpretation as users playing mixed strategies in a game-like setting with thousands of other users and thousands of available pure strategies. In this interpretation, our task is then inverse reinforcement learning: recovering users' reward functions based on observed behavior.
Mental health service use among homeless and never-homeless men with schizophrenia

Objective The study compared patterns of previous mental health service use among 100 homeless men with schizophrenia and 100 men with schizophrenia who had never been homeless and explored whether differences in use of services were related to severity of illness. Methods Subjects were recruited from shelters, clinics, and inpatient psychiatric programs in New York City. Clinical interviewers used standardized research instruments to collect data on psychiatric treatment history, mental health service use within the past 12 months, adequacy of discharge planning from the most recent psychiatric hospitalization, positive and negative-symptom levels, and presence of concurrent substance abuse and antisocial personality disorder. Results and conclusions Homeless subjects and never-homeless subjects had similar treatment histories and recent patterns of inpatient, outpatient, and emergency service use. However, the homeless men were more likely to have been discharged from their most recent psychiatric hospitalization against medical advice and to have less adequate discharge planning for living arrangements, aftercare, and finances. Inadequacies in discharge planning were most apparent among homeless men with triple disorders of schizophrenia, substance abuse, and antisocial personality disorder.
Stability and Resolution in Thermal Imaging

This paper examines an inverse problem which arises in thermal imaging. We investigate the problem of detecting and imaging corrosion in a material sample by applying a heat flux and measuring the induced temperature on the sample's exterior boundary. The goal is to identify the profile of some inaccessible portion of the boundary. We study the case in which one has data at every point on the boundary of the region, as well as the case in which only finitely many measurements are available. An inversion procedure is developed and used to study the stability of the inverse problem for various experimental configurations.
Environmental contaminants and microRNA regulation: Transcription factors as regulators of toxicant-altered microRNA expression.

Abstract MicroRNAs (miRNAs) regulate gene expression by binding mRNA and inhibiting translation and/or inducing degradation of the associated transcripts. Expression levels of miRNAs have been shown to be altered in response to environmental toxicants, thus impacting cellular function and influencing disease risk. Transcription factors (TFs) are known to be altered in response to environmental toxicants and play a critical role in the regulation of miRNA expression. To date, environmentally-responsive TFs that are important for regulating miRNAs remain understudied. In a state-of-the-art analysis, we utilized an in silico bioinformatic approach to characterize potential transcriptional regulators of environmentally-responsive miRNAs. Using the miRStart database, genomic sequences of promoter regions for all available human miRNAs (n = 847) were identified and promoter regions were defined as − 1000/+500 base pairs from the transcription start site. Subsequently, the promoter region sequences of environmentally-responsive miRNAs (n = 128) were analyzed using enrichment analysis to determine overrepresented TF binding sites (TFBS). While most (56/73) TFs differed across environmental contaminants, a set of 17 TFs was enriched for promoter binding among miRNAs responsive to numerous environmental contaminants. Of these, one TF was common to miRNAs altered by the majority of environmental contaminants, namely SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 3 (SMARCA3). These identified TFs represent candidate common transcriptional regulators of miRNAs perturbed by environmental toxicants.
U.S. Savings Bonds: the planned-gift forgotten asset.

As older Americans take a close look at their assets, promote their interest in unlocking the wealth accumulation in their U.S. Saving Bond holdings. Use careful planning and advice when promoting this gift strategy.
The Monopoly and Cournot-Nash Equilibria under Dynamic Conditions

We now resume the study of optimal policies and expectations for n competing firms begun in chapter IV. Our concern is with the dynamic properties of the competitive and monopoly equilibria. Despite the greater difficulties of the analysis, many conclusions applicable to the static model remain valid in a dynamic setting, but certain new problems appear, and we shall need more powerful mathematical tools to solve them.
Battalion Commander and Opposition Spokesman

The few days after his resignation speech Churchill spent largely in preparing for his departure for France to join his regiment. He was pleased by the reactions to his speech: The Times described it as ‘an undoubted Parliamentary triumph’ and the Manchester Guardian lamented his resignation as ‘a grave public misfortune’. C. P. Scott, the Guardian editor, had visited him a few days previously and had been shown some of the confidential papers about the Dardanelles operation.1 The Churchill family was now living at 41 Cromwell Road, which they shared with Jack Churchill’s family. There were two nurses and two nurserymaids to look after the children, and so it was a large household.2 On the 16th there was a farewell luncheon party, at which Violet Asquith and her step-mother Margot were present: they arrived to find ‘baggage and other military impedimenta’ in the hall and on the landings. Churchill was excited at the prospect of going to the front but, as Violet said, ‘for most of us it was a kind of a wake’.3
Transition-Metal-Catalyzed C–H Alkylation Using Alkenes

Alkylation reactions represent an important organic transformation to form C–C bonds. In addition to conventional approaches with alkyl halides or sulfonates as alkylating agents, the use of unactivated olefins for alkylations has become attractive from both cost and sustainability viewpoints. This Review summarizes transition-metal-catalyzed alkylations of various carbon–hydrogen bonds (addition of C–H bonds across olefins) using regular olefins or 1,3-dienes up to May 2016. According to the mode of activation, the Review is divided into two sections: alkylation via C–H activation and alkylation via olefin activation.
Teachers’ experiences with a state-mandated kindergarten readiness assessment

AbstractThis study used an embedded mixed method design to examine teachers’ experiences with a state-mandated kindergarten readiness assessment during its inaugural year. Participants were 143 kindergarten teachers from one county in a Midwestern state. In general, teachers did not perceive the Kindergarten Readiness Assessment as useful for one of its intended purposes of guiding instruction. Our findings did not indicate an adversity to assessment in general. Rather, perceptions that the new KRA was less useful for practice seemed to stem from administration issues, problems with the content assessed by the KRA, and participants’ misunderstandings regarding the purpose of the KRA. Furthermore, participants reported that the KRA took away valuable time needed to help students adjust to their first time in formal schooling and needed to create a classroom community. Implications for creating and implementing kindergarten readiness and other assessments as well as preparing teachers to use readiness asses...
Abstract NTOC-105: RUXOLITINIB SENSITIZES OVARIAN CANCER CELLS TO LOW–DOSE PACLITAXEL THERAPY

In ovarian cancer chemotherapy initially reduces tumor burden; however, >70% of patients experience tumor recurrence, creating a need for additional therapies. We evaluated the ability of Ruxolitinib, a FDA approved JAK 1/2 kinase inhibitor, as a potential adjunctive therapy for paclitaxel treatment of ovarian cancer. Using murine ID8 and human TOV-112D ovarian cancer cells we tested the ability of Ruxolitinib alone and in combination with low-dose paclitaxel to limit cell proliferation and colony formation in vitro. Additionally, using flow cytometry we assessed the capacity of paclitaxel to induce the expression of cell surface markers associated with stemness and the cellular stress response. We next determined if Ruxolitinib could reduce paclitaxel-induced expression of stemness and stress markers. Finally daily administration of Ruxolitinib, both alone and in combination with a single low-dose administration of paclitaxel, was tested for the capacity to reduce tumor growth and extend survival using the syngeneic ID8 luciferase-expressing model of ovarian cancer in C57Bl/6 mice. Our in vitro data demonstrate that Ruxolitinib can sensitize both murine ID8 and human TOV-112D cells to low concentrations of paclitaxel, as evidenced by a significant reduction of cell proliferation and colony formation. We find that pre-incubation with Ruxolitinib is sufficient to sensitize cells to subsequent incubation with paclitaxel. Paclitaxel-induced expression of stemness and stress markers (SCA-1, GRP78 and CD133) is reduced by co-incubation with Ruxolitinib. In vivo, Ruxolitinib plus administration of a single low-dose paclitaxel treatment is sufficient to limit tumor growth and significantly extend median survival from in mice bearing ID8 ovarian cancer tumors (Control 59days vs Ruxolitinib-paclitaxel 77 days). Together, these data indicate that Ruxolitinib can increase the susceptibility of both murine and human ovarian cancer cells to reduced concentrations paclitaxel chemotherapy in vitro and that combination therapy with Ruxolitinib and a single low-dose paclitaxel administration extends survival in mice. Our data provide important pre-clinical data to support the use of Ruxolitinib to enhance the efficacy of paclitaxel therapy for patients with ovarian cancer. Citation Format: Patrick Reeves PhD, Mojgan Abbaslou MD, Mark C. Poznansky MD PHD. RUXOLITINIB SENSITIZES OVARIAN CANCER CELLS TO LOW–DOSE PACLITAXEL THERAPY [abstract]. In: Proceedings of the 11th Biennial Ovarian Cancer Research Symposium; Sep 12-13, 2016; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(11 Suppl):Abstract nr NTOC-105.
Multistructured Nanogel‐Based Networks Formed from Interfacial Redox Polymerizations for Modulating Small Molecule Release

Uniform, 3D nanogel-based coatings are generated on polymeric substrates using an interfacial redox polymerization. Diffusion of a reducing agent from a core material into a solution of acrylate-functionalized nanogels and an oxidizer generates free radicals that initiate nanogel crosslinking selectively at the gel surface. Coating thickness is controlled between 20 and 150 µm by varying reaction time and initiator concentration. Controlling the structure of the final nanogel-based coating is demonstrated to predictably change the diffusion coefficient of a small molecule drug loaded into the core material. Multidrug release from the coating and the core is demonstrated with model dyes. This study showcases the ability to design multifunctional networks for controlled release using a simple, mild coating procedure.
Adsorption dynamics of polyatomic molecules on planar surfaces.

This is a comparative study of the adsorption dynamics of increasingly longer polyatomic molecules on a planar surface. We perform kinetic Monte Carlo simulations of the gas uptake to identify the molecular mechanisms and parameters that govern the evolution of the adsorbed film to its final equilibrium state. We also develop an analytical model for the adsorption dynamics of mono-atomic gases that demonstrates a direct correlation between the strength of the gas–gas interaction and the adsorption rate dependence with coverage. When this is added to the effect of the orientational freedom of polyatomic molecules, we are able to explain the change in the adsorption rate dependence observed experimentally for longer molecules.
RFLP maps of barley

Barley, Hordeum vulgare L., is among the oldest cultivated crops dating 5000 to 7000 years B.C. (Clark 1967; Harlan 1976, 1979) and perhaps much older (Wendorf et al. 1979). Barley has also been a favorite genetic experimental organism since the rediscovery of Mendel’s laws of heredity (Tschermak 1901; cited from Smith 1951). The widespread use of barley is attributable to its diploid nature (2n = 2x = 14), self fertility, large chromosomes (6–8 μm), high degree of natural and easily inducible variation, ease of hybridization, wide adaptability, and relatively limited space requirements. The early literature on the genetics of barley and related information has been reviewed (Smith 1951; Nilan 1964, 1974; Briggs 1978) and more recently in Rasmusson (1985) and Shewry (1992). A comprehensive listing and description of the genes known at the time can be found in Sogaard and von Wettstein-Knowles (1987), updated by Von Wettstein-Knowles (1992). Periodic publications such as the Proceedings of International Barley Genetic Symposia (Lamberts et al. 1964; Nilan 1971; Gaul 1976; Asher et al. 1981; Yasuda and Konishi 1987; Munck 1992) and the annual Barley Genetics Newsletter (since 1971) summarize and update the barley genetic literature.
Better together: Developmental screening and monitoring best identify children who need early intervention.

Abstract Background Widely recommended developmental surveillance methods include developmental monitoring (DM) and development screening (DS). Much research has been done on DS, but very little research has compared the effectiveness of DM and DS together. Objectives To investigate the relationship between DM and DS in Part C early intervention (EI) service receipt. Methods Authors used data from the 2007/2008 and 2011/2012 National Survey of Children's Health (NSCH). Authors report the prevalence of children aged 10 months to 3 years who received (a) DM only, (b) DS only, (c) both DM and DS, and (c) no DM or DS across survey years. Authors compare the odds of EI receipt across these groups. Results During both periods, estimated EI receipt prevalence was higher for children receiving both DM and DS (8.38% in 2007/2008; 6.47% in 2011/2012) compared to children receiving no DM or DS (1.31% in 2007/2008; 1.92% in 2011/2012), DM alone (2.74% in 2007/2008; 2.70% in 2011/2012), or DS alone (3.59% in 2007/2008; 3.09% in 2011/2012) (for both time frames, p Conclusions Children receiving DM and DS together were more likely to receive EI compared to children receiving DM alone, DS alone, or neither DM nor DS. These findings support the AAP recommendations indicating that DM and DS are complementary strategies for improving early identification and linkage to EI for young children.
Noise performance of a white-light optical signal processor. II: Spatially partially coherent illumination

A study of the effects of spatially and partially coherent illumination on the noise performance of an optical processor is presented here. Noise arising from defects in the object plane and the Fourier plane are considered separately. Two important types of noise are analyzed in detail: (a) amplitude noise and (b) ramdom phase noise. The results illustrate that the effects of the object phase noise can be reduced when the requirements on spatial coherence are relaxed. Also, the noise at the Fourier plane can be effectively eliminated when a spatially incoherent light source is employed.
Conventional and quantitative MRI in a novel feline model of demyelination and endogenous remyelination

Background The feeding of irradiated food to healthy adult cats results in widespread, noninflammatory demyelination of the central nervous system (CNS); a return to a normal diet results in endogenous remyelination with functional recovery. This recently discovered, reversible disease might provide a compelling clinical neuroimaging model system for the development and testing of myelin-directed MRI methods as well as future remyelination therapies. Purpose Identify the noninvasive imaging characteristics of this new disease model and determine whether it features measurable changes on conventional and quantitative MRI. Study type Pilot study. Animal model Ten adult cats at various stages of demyelinating disease induced by an irradiated diet (35-55 kGy), and during recovery following a return to a normal diet. Field strength/sequence Conventional (T2 -weighted) and quantitative (diffusion tensor, magnetization transfer) at 3T. Assessment MRI of the brain, optic nerves, and cervical spinal cord; a subset of diseased cats was euthanized for comparative histopathology. Statistical tests Descriptive statistics. Results Disease produced T2 prolongation, progressing from patchy to diffuse throughout most of the cerebral white matter (eventually involving U-fibers) and spinal cord (primarily dorsal columns, reminiscent of subacute combined degeneration but without evidence of B12 deficiency). Magnetization transfer parameters decreased by 50-53% in cerebral white matter and by 25-30% in optic nerves and spinal cord dorsal columns. Fractional diffusion anisotropy decreased by up to 20% in pyramidal tracts, primarily driven by increased radial diffusivity consistent with axon preservation. Histopathology showed scattered myelin vacuolation of major white matter tracts as well as many thin myelin sheaths consistent with remyelination in the recovery phase, which was detectable on magnetization transfer imaging. Data conclusion Feline irradiated diet-induced demyelination features noninvasively imageable and quantifiable demyelination and remyelination of the CNS. It is therefore a compelling clinical neuroimaging model system. Level of evidence 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1304-1311.
Contrast-Enhanced Ultrasound to Quantifyc Perfusion in a Machine-Perfused Pig Liver

This paper introduces a non-invasive, contrastenhanced ultrasound (CEUS) infusion method to quantify the health of viable donor livers. The method uses the infusion of microbubbles and their destruction and subsequent replenishment to measure the perfusion rate in the liver microvasculature. The proposed method improves on the previous parameter extraction approaches applied to the flashreplenishment technique by addressing the effects of the microbubble mixing within the perfusate bath and destruction rate. By doing so, the tissue perfusion rate can be extracted from the data even though the microbubble concentration is not constant throughout image acquisition. The measured changes in the tissue perfusion rate showed that CEUS infusion is a viable biomarker for assessing liver health.
The Desire for Porn and Partner?: Investigating the Role of Scripts in Affectionate Communication, Sexual Desire, and Pornography Consumption and Guilt in Young Adults’ Romantic Relationships

The present study extends affection exchange theory (AET) by examining the effects of pornography consumption and guilt on sexual desire for one’s partner and relationship satisfaction through the ...
Formaldehyde release from baby wipes: Analysis using the chromotropic acid method

Background Formaldehyde is a common preservative and strong sensitizer. Objective The aim of the study was to evaluate the release of formaldehyde from baby/toddler wet wipes using the chromotropic acid method (CAM). Methods An online search of best-selling baby wipes was conducted. None declared formaldehyde or formaldehyde-releasing preservatives. Standard CAM procedures were used: a 1 × 1-in square of fresh wipe was placed in a bottle with an open vial of 4 mg/1 mL of chromotropic acid and sulfuric acid solution, sealed, and stored for 48 hours. Formalin and water served as controls. A blinded investigator graded color change (negative, indeterminate, mild, moderate, or strong). For quality control, 20% of all samples as well as all positives were retested. Results Fifty-one popular and highly reviewed baby and toddler wet wipe products were tested using CAM. Twelve wipes (24%) released formaldehyde (8 mild, 4 moderate/strong). Chromotropic acid method testing of 9 wipes (18%) was indeterminate and 30 (59%) were negative. Conclusions Almost one quarter of baby/toddler wet wipes released formaldehyde when evaluated with CAM. Patients and clinicians should be aware of this potentially undeclared source of this common allergen.
Project based learning in computer science: a student and research advisor's perspective

The dominant pedagogy for Computer Science education often focuses on teaching isolated skills across a set of core courses. Recently the community has adopted Senior Capstone Projects and Project Based Learning to provide a cumulating experience designed to include a clear focus on: critical thinking and problem solving; collaboration and leadership; verbal and written communications; and independent work. This paper discusses the application of project-based learning to Computer Science education, providing a student's perspective and a research advisor's perspective. An example of applying Project Based Learning is presented and the effectiveness and relevance of Project Based Learning for Computer Science education is discussed.
Stereotactic body radiation therapy for oligometastatic renal cell carcinoma: improving outcomes in an otherwise radioresistant malignancy

Franzese et al . recently analyzed the outcomes of patients treated at their institution with stereotactic body radiation therapy (SBRT) for oligometastatic renal cell carcinoma (RCC) (1). They reported a 2-year survival rate from SBRT of 100% and excellent local control with very few toxicities. As we place their findings into the context of overall management of metastatic RCC (mRCC), a number of points warrant discussion.
Bubbles and Dust: Experimental Results of Dissolution Rates of Metal Salts and Glasses From Volcanic Ash Deposits in Terms of Surface Area, Chemistry, and Human Health Impacts

Explosive volcanic eruptions lead to ash deposition and subsequent leaching of contaminants into soils or surface water, impacting flora and fauna, including human health. This study determined the control of ash surface area and chemical composition on ash dissolution rates. Fresh, unhydrated ash samples from four contrasting volcanoes were analyzed in the laboratory. Column leachate tests were used to compare leaching rates over a range of basaltic to andesitic ashes as a function of time and surface area, to analyze the effects of ash deposition. It was found that surface area, measured both geometrically and by multipoint Brunauer-Emmett-Teller analysis, generally increases for a short time, gradually decreases, then increases over the rest of the leaching experiment, due to area to mass ratio fluctuations. After the column leachate tests, postleaching water analyses for elemental compositions were conducted by inductively coupled plasma-mass spectrometry and ion chromatography. Steady state dissolution rates initially decayed rapidly due to the smallest size fraction of ash (dust), which provides a large area of fresh leachable surfaces as well as the rapid dissolution of highly soluble metal salts. Some of the dissolved concentrations of elements relevant to human and ecosystem health such as F, Cd, Se, As, and Cr rose above World Health Organization (WHO) drinking water standards within an hour of experimental leaching. In nature, however, safe consumption standards are further dependent upon bioaccumulation and chronic exposure. As such, individual and recurring ash deposition events have applications to emergency response and preparedness in volcanic regions.
Intramural coronary pattern in patients with transposition: incidence and impact on follow-up.

OBJECTIVES Coronary complications are still the main reason for early mortality after an arterial switch operation. The high incidence of coronary anomalies in patients with transposition of the great arteries may increase the difficulty of coronary transfer, and among them, an intramural pattern was shown to be an independent risk factor of early mortality. However, recently published studies have reported that this rare coronary variant has no impact on the survival rate. The aim of this study was to assess the frequency of intramural coronary patterns in patients with transposition and the impact on overall mortality after an arterial switch operation. Additionally, we presented all coronary arrangements associated with intramural patterns in our cohort and the surgical techniques used to manage them successfully. METHODS All arterial switch operations were retrospectively reviewed. In each case, the surgical reports contained detailed graphical representations and coronary anatomy patterns. All operatively confirmed intramural patterns were included in the analysis. RESULTS Among 806 patients, 271 patients had coronary anomalies (33.62%), and 28 patients had an intramural pattern (3.47%), which was frequently associated with other complex coronary anomalies (P < 0.001). Overall survival was significantly higher in patients with intramural coronary artery patterns than in those with other coronary variants (21.34% vs 8.74%, P = 0.024, log-rank test). CONCLUSIONS Intramural patterns associated with transposition remain a surgical challenge and increase overall mortality in our cohort. To reliably confirm or reject the significance of the observed impact of this rare coronary variant, a multicentre data analysis is required.
Drinking and Disappearing: Vampiric Orality and Age As Challenging the Youthful Male Gaze in Let Me In

This article analyzes the 2010 vampire horror film Let Me In, focusing on how age and gender are represented through the vampiric mouth. Drawing upon critical feminist age scholarship and Freudian ...
Perioperative Analgesia for Patients Undergoing Thyroidectomy and Parathyroidectomy: An Evidence-Based Review.

Objective:To perform an evidence-based systematic review evaluating perioperative analgesia, including opioid alternatives, used for patients undergoing thyroidectomy and parathyroidectomy.Methods:...
Survey of the Oregon Bench and Bar on the Oregon Rules of Civil Procedure

This Report sets forth the results of the Institute for the Advancement of the American Legal System’s Survey of the Oregon Bench and Bar on the Oregon Rules of Civil Procedure. The Survey explored the views of members of the Oregon State Bar concerning civil procedure in Circuit Court, the state court of general jurisdiction. There are significant differences between the Oregon Rules of Civil Procedure and the procedural rules used in federal court and neighboring state courts. This survey was developed to examine the practical impact of these rules variations. The global research questions included: - Does fact pleading advance the goals of efficiency and affordability, without sacrificing procedural fairness? - Does a time limit for holding trial advance the goals of efficiency and affordability, and without sacrificing procedural fairness? - Does limiting discovery advance the goals of efficiency and affordability, without sacrificing procedural fairness? - To what extent are the Oregon rules followed, respected, and enforced? - What role does culture play? - Does mandatory arbitration provide a satisfactory alternative to litigation? - How could Oregon’s system be further improved?
Prostate Artery Embolization Used in the Management of Transfusion-Dependent Hematuria After Prostatic Urethral Lift Procedure in a Patient with Thrombocytopenia: A Case Report.

Background: The prostatic urethral lift (PUL) procedure is a novel therapeutic method to treat lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). Gross hematuria after this procedure has been reported to be mild and transient. This report highlights a case of refractory transfusion-dependent hematuria after the PUL procedure in addition to its management with selective prostatic arterial embolization (PAE). Case Presentation: A 78-year-old Caucasian man with a history of myelodysplastic syndrome, thrombocytopenia, and intermittent urinary retention secondary to BPH underwent a PUL procedure. Before the procedure he received a platelet transfusion making his platelet count 58,000/μL. The day after the procedure he was admitted to a hospital for gross hematuria with clot retention. He was started on continuous bladder irrigation and taken to the operating room for clot evacuation and fulguration of prostate. His thrombocytopenia and anemia were managed with transfusions. He was treated with desmopressin, aminocaproic acid, and intravesical 1% alum without improvement. He returned to the operating room for clot evacuation in addition to photoselective vaporization of the prostate laser ablation of the prostatic fossa. He eventually required a total of four transurethral fulgurations without improvement in transfusion-dependent hematuria. Ultimately, resolution of the hematuria was achieved through bilateral PAE with Embosphere® Microspheres performed by interventional radiology. He was discharged home 2 days after the embolization procedure without recurrence of hematuria or urinary retention at a 6-month follow-up visit. Conclusion: The PUL procedure has been shown to be an effective alternative to more invasive surgical options for LUTS caused by BPH. Despite careful consideration in an attempt to alleviate urinary retention, PUL still resulted in significant bleeding in this patient with thrombocytopenia. This is the first report to highlight the use of bilateral PAE as a method for achieving control of severe refractory hematuria after PUL.
Use of Cryotherapy for Managing Chronic Pain: An Evidence-Based Narrative.

Cryotherapy has been used to reduce chronic pain for many years due in part to its ease of use, affordability, and simplicity. It can be applied either locally (e.g., ice packs) or non-locally (e.g., partial and whole-body cryotherapy) depending on the location of the pain. To determine the overall effectiveness of cryotherapy at reducing chronic pain by characterizing the currently available evidence supporting the use and effects of cryotherapy on chronic pain associated with chronic diseases. A narrative review of original research studies assessing the efficacy of cryotherapy in alleviating chronic pain. A PubMed database search was performed to find human studies between the years 2000 and 2020 that included the application of cryotherapy in patients with chronic pain associated with chronic diseases. A review of the relevant references was also performed to gather more articles. Data was extracted, summarized into tables, and qualitatively analyzed. Twenty-five studies (22 randomized controlled trials, one prospective analysis, 1 one-group pretest/posttest study, and one case–control study) were included after the literature search. Both local and non-local cryotherapy applications show promise in reducing chronic pain associated with various chronic diseases including those of rheumatic and degenerative origin. Cryotherapy appears to be a safe therapy in carefully selected patients, with only minimal adverse effects reported in the literature. Meta-analysis was not possible given the many differences between studies. Cross-study data homogenization and comparison between studies proved fairly difficult due to the lack of standardized studies, various uses and practice types of cryotherapy, and lack of control groups in some studies. Local and non-local cryotherapy can be low-risk and easy treatment options to add in the management of chronic pain in carefully selected patients. However, long-term effects, a standardized approach, and careful study of other chronic pain syndromes should be considered in future research to further support the use of cryotherapy in the management of chronic pain.
Cost-Effectiveness of Offering Cervical Cancer Screening with HPV Self-Sampling among African-American Women in the Mississippi Delta

Background: African-American women in the United States have an elevated risk of cervical cancer incidence and mortality. In the Mississippi Delta, cervical cancer disparities are particularly stark. Methods: We conducted a micro-costing study alongside a group randomized trial that evaluated the efficacy of a patient-centered approach (“Choice” between self-collection at home for HPV testing or current standard of care within the public health system in Mississippi) versus the current standard of care [“Standard-of-care screening,” involving cytology (i.e., Pap) and HPV co-testing at the Health Department clinics]. The interventions in both study arms were delivered by community health workers (CHW). Using cost, screening uptake, and colposcopy adherence data from the trial, we informed a mathematical model of HPV infection and cervical carcinogenesis to conduct a cost-effectiveness analysis comparing the “Choice” and “Standard-of-care screening” interventions among un/underscreened African-American women in the Mississippi Delta. Results: When each intervention was simulated every 5 years from ages 25 to 65 years, the “Standard-of-care screening” strategy reduced cancer risk by 6.4% and was not an efficient strategy; “Choice” was more effective and efficient, reducing lifetime risk of cervical cancer by 14.8% and costing $62,720 per year of life saved (YLS). Screening uptake and colposcopy adherence were key drivers of intervention cost-effectiveness. Conclusions: Offering “Choice” to un/underscreened African-American women in the Mississippi Delta led to greater uptake than CHW-facilitated screening at the Health Department, and may be cost-effective. Impact: We evaluated the cost-effectiveness of an HPV self-collection intervention to reduce disparities.
"Raising HOPE": Improved Outcomes for HIV/HCV-coinfected Liver Transplant Recipients in the Direct-acting Antiviral Era.

The 2013 HIV Organ Policy Equity Act has increased liver transplantation (LT) in HIV+ patients; however, transplant centers may remain reluctant to perform LT in HIV/hepatitis C virus (HCV)-coinfected patients due to inferior outcomes. We aimed to assess how direct-acting antivirals (DAAs) have impacted HIV+/HCV+-coinfected LT recipient outcomes. Methods national data including 70 125 adult LT recipients between 2008 and 2019 were analyzed. Kaplan-Meier survival analysis and Cox proportional hazards model were used to analyze outcomes. Results LT for HIV+ individuals increased in the DAA era from 28 in 2014 to 64 in 2019 (23 had HIV+/HCV+ coinfection). In the pre-DAA era, HIV+/HCV+-coinfected LT recipients had an increased risk of graft failure compared with HIV-/HCV--uninfected LT recipients (hazard ratio [HR], 1.85; P < 0.001). In contrast, there was no difference in graft failure between HIV+/HCV+-coinfected versus HIV-/HCV--uninfected LT recipients in the DAA era (HR, 1.24; P = 0.308). Among coinfected LT recipients in the DAA era, 1- and 3-y cumulative graft survivals were 88.6% and 81.7% compared with 76.3% and 58.0% in the pre-DAA era, respectively (P = 0.006). In Cox analysis, HCV coinfection was not associated with graft failure (HR, 1.00; 95% confidence interval, 0.53-1.89) among HIV+ LT recipients in the DAA era (n = 271). Black and Hispanic populations accounted for almost half of HIV+/HCV+ LTs in the DAA era. Conclusions HIV+/HCV+-coinfected LT recipient outcomes have improved significantly in the DAA era. Our results should offer reassurance to transplant centers and encourage timely transplantation referral of HIV patients with decompensated cirrhosis, including patients coinfected with HCV.