Peanuts and LEAP Data

1. Lucy C. Holmes, MD, MPH* 2. Heather K. Lehman, MD* 1. *Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY 1. 1. Du Toit G, 2. Roberts G, 3. Sayre PH, 4. et al Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy. Du Toit G, Roberts G, Sayre PH, et al. N Engl J Med. 2015;372(9):803-813 [OpenUrl][1][CrossRef][2][PubMed][3] 2. 1. Du Toit G, 2. Sayre PH, 3. Roberts G, 4. et al Effect of Avoidance on Peanut Allergy after Early Peanut Consumption. Du Toit G, Sayre PH, Roberts G, et al. N Engl J Med. 2016;374(15):1435-1443 [OpenUrl][4][CrossRef][5][PubMed][6] 3. 1. Feeney M, 2. Du Toit G, 3. Roberts G, 4. et al Impact of Peanut Consumption in the LEAP Study: Feasibility, Growth, and Nutrition. Feeney M, Du Toit G, Roberts G, et al. J Allergy Clin Immunol. 2016;138(4):1108-1118 [OpenUrl][7][CrossRef][8][PubMed][9] 4. 1. Du Toit G, 2. Katz Y, 3. Sasieni P, 4. et al Early Consumption of Peanuts in Infancy Is Associated with a Low Prevalence of Peanut Allergy. Du Toit G, Katz Y, Sasieni P, et al. J Allergy Clin Immunol. 2008;122(5):984-991 [OpenUrl][10][CrossRef][11][PubMed][12][Web of Science][13] The incidence of peanut allergy has increased in the last decade in Western countries, and it is the leading cause of fatal allergic reactions due to food in the United States. In the past, the American Academy of Pediatrics, Committee on Nutrition recommended that young infants at high risk for food allergy avoid allergenic foods. However, studies in recent years have found that elimination diets do not prevent the development of immunoglobulin E-mediated food allergy. In addition, cultures in which peanut is consumed regularly during infancy have substantially lower rates of peanut allergy than cultures where peanut introduction is delayed beyond the first year of age. The Learning Early about Peanut Allergy (LEAP) trial was designed to determine whether introducing peanuts into the diets of young infants at high risk for peanut allergy would prevent the development of an allergy to this food. The LEAP trial was … [1]: {openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D372%26rft.spage%253D803%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1414850%26rft_id%253Dinfo%253Apmid%252F25705822%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa1414850&link_type=DOI [3]: /lookup/external-ref?access_num=25705822&link_type=MED&atom=%2Fpedsinreview%2F38%2F8%2F390.atom [4]: {openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft.volume%253D374%26rft.spage%253D1435%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1514209%26rft_id%253Dinfo%253Apmid%252F26942922%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [5]: /lookup/external-ref?access_num=10.1056/NEJMoa1514209&link_type=DOI [6]: /lookup/external-ref?access_num=26942922&link_type=MED&atom=%2Fpedsinreview%2F38%2F8%2F390.atom [7]: {openurl}?query=rft.jtitle%253DJ%2BAllergy%2BClin%2BImmunol%26rft.volume%253D138%26rft.spage%253D1108%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jaci.2016.04.016%26rft_id%253Dinfo%253Apmid%252F27297994%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [8]: /lookup/external-ref?access_num=10.1016/j.jaci.2016.04.016&link_type=DOI [9]: /lookup/external-ref?access_num=27297994&link_type=MED&atom=%2Fpedsinreview%2F38%2F8%2F390.atom [10]: {openurl}?query=rft.jtitle%253DJournal%2Bof%2BAllergy%2Band%2BClinical%2BImmunology%26rft.stitle%253DJournal%2Bof%2BAllergy%2Band%2BClinical%2BImmunology%26rft.aulast%253DDu%2BToit%26rft.auinit1%253DG.%26rft.volume%253D122%26rft.issue%253D5%26rft.spage%253D984%26rft.epage%253D991%26rft.atitle%253DEarly%2Bconsumption%2Bof%2Bpeanuts%2Bin%2Binfancy%2Bis%2Bassociated%2Bwith%2Ba%2Blow%2Bprevalence%2Bof%2Bpeanut%2Ballergy.%26rft_id%253Dinfo%253Adoi%252F10.1016%252Fj.jaci.2008.08.039%26rft_id%253Dinfo%253Apmid%252F19000582%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [11]: /lookup/external-ref?access_num=10.1016/j.jaci.2008.08.039&link_type=DOI [12]: /lookup/external-ref?access_num=19000582&link_type=MED&atom=%2Fpedsinreview%2F38%2F8%2F390.atom [13]: /lookup/external-ref?access_num=000260940100019&link_type=ISI