cssi/SciSciGPT-SciSciNet huggingface dataset:
Evaluating the Impact of the “Getting The Love You Want” Couples Workshop on Relational Satisfaction and Communication Patterns

Over the past 20 years, couples around the world have participated in “Getting The Love You Want” workshops in an effort to improve their relationships, yet empirical analysis of relationship improvement from these workshops is limited. The content of the workshops is based on the theory and practice of Imago relationship therapy and participants from three workshops participated in this study. Standard measures were used in preworkshop, postworkshop, and 3-month follow-up assessments to determine if the workshop had a positive impact on relational satisfaction and communication patterns of participants and if the impacts persisted after 3 months. Participant scores on both the Dyadic Adjustment Scale and the Communication Pattern Questionnaire showed significant increases post workshop, indicating the potential impact of these interventions in the short term.
Problems and Problem-resolution Structure of Television Advertisements

Television advertisements deal with a host of human problems by identifying a problem or cultivating a perception that a problem exists, then demonstrating the capacity of a product to resolve that...
Verification and Validation of Reusable ADA Components

This paper discusses the verification and validation (V&V) of reusable software written in the Ada programming language. The research includes methodological and experimental studies of aspects of V&V that are affected when reusable components are considered.
Development of an Enhanced Phenotypic Screen of Cytotoxic T-Lymphocyte Lytic Granule Exocytosis Suitable for Use with Synthetic Compound and Natural Product Collections

We previously developed an assay of cytotoxic T-lymphocyte lytic granule exocytosis based on externalization of LAMP-1/CD107A using nonphysiological stimuli to generate maximal levels of exocytosis. Here, we used polystyrene beads coated with anti-CD3 antibodies to stimulate cells. Light scatter let us distinguish cells that contacted beads from cells that had not, allowing comparison of signaling events and exocytosis from stimulated and unstimulated cells in one sample. Bead stimulation resulted in submaximal exocytosis, making it possible to detect compounds that either augment or inhibit lytic granule exocytosis. Coupled with the assay's ability to distinguish responses in cells that have and have not contacted a stimulatory bead, it is possible to detect three kinds of compounds: inhibitors, stimulators, which cause exocytosis, and augmenters, which enhance receptor-stimulated exocytosis. To validate the assay, we screened a set of synthetic compounds identified using our previous assay and a library of 320 extracts prepared from tunicate-associated bacteria. One of the extracts augmented exocytosis threefold. Activity-guided fractionation and structure elucidation revealed that this compound is the known PKC activator teleocidin A-1. We conclude that our modified assay is suitable for screening synthetic compound plates and natural product collections, and will be useful for identifying immunologically active small molecules.
Colonization and Intraplant Distribution of Thrips tabaci (Thysanoptera: Thripidae) on Cabbage

To examine temporal aspects of Thrips tabaci Lindeman, colonization of cabbage, uninfected cabbage plants were placed adjacent to wheat, oat, and alfalfa fields on a weekly basis from July to October during 1983 and 1984. These cabbage plants were colonized by T. tabaci, with highest oviposition coinciding with emigration of T. tabaci adults from the adjacent field or forage crop. To examine within-plant colonization of cabbage, plants were sampled for 20 consecutive weeks in 1982. Individual leaves were excised, washed in 70% ethanol to remove thrips, and the thrips were identified. Only T. tabaci colonized cabbage and, before head formation, T. tabaci adults were most commonly found on the developing meristem, while larvae were most abundant on frame leaves. Once head formation began, thrips populations increased rapidly within the head and remained high until harvest. T. tabaci larvae, pupae, and adults were found in the first 11 layers of mature heads.
High expression of the L-Methionine γ-lyase gene in E. coli

Objective: To identify and highly express the L-Methionine γ-lyase gene from Trichomonas vaginalis(TVMGL).Methods: The TVMGL gene was cloned into pGEX 4T-2,the recombinant protein expressed in E.coli DH5αand confirmed by SDS-PAGE.Results: Denaturing SDS-PAGE analysis confirmed the predicted size of the fusion protein(GST-TVMGL,68 000) and showed high purity after subsequent affinity chromatography on Glutathione sepharose 4B.The target proteins amounted to 34% of the total bacteria proteins.Conclusion: The L-Methionine γ-lyase gene was highly expressed in E.coli.
Psychosocial and Psychological Interventions for Preventing Postpartum Depression

A range of prevention strategies can reduce the risk of postpartum depression, but more study is needed to determine which interventions are most effective.
Urodynamic Norms in Women. I. Normals Versus Stress Incontinents

Urodynamic statistics for normal women were compared to similar norms for stress incontinent women. It was concluded that 1) the reduction of flow rate in stress incontinent patients appears to be the result, with high probability of pathologic changes in the function of the distal urethra, 2) stress incontinence does not affect the combined effects of bladder pressure and the proximal urethral resistance during voiding as reflected in velocity, 3) the distal urethral cross-sectional area appears to be under neuromuscular control and 4) the distal urethra of stress incontinent women appears to be incapable of opening as widely as the distal urethra of normal women. It is not currently possible to assign anatomical or physiological causes to the observed phenomena.
The Influence of Motion on the Electromagnetic Field Equations

We have already obtained the electromagnetic jump conditions across stationary surfaces of discontinuity in Sec. 10.4. But since we are ultimately interested in considering moving deformable media, we will need the electromagnetic jump conditions at moving surfaces of discontinuity. As we shall see the fact that the surfaces are moving alters the jump conditions. Consider the surface S moving with velocity v shown in Figure 32. The surface has unit normal n and two orthogonal unit vectors τ and N normal to n, but otherwise arbitrary and satisfying $$\tau = \operatorname{n} \times \operatorname{N} .$$ (12.1.1)
Efficacy of low-activity, microbial phytase in improving the bioavailability of phosphorus in corn-soybean meal diets for pigs.

Two experiments involving 115 pigs were conducted to assess the efficacy of a microbial phytase (Allzyme Phytase; Alltech, Nicholasville, KY) produced by Aspergillus niger in low-P, corn-soybean meal-based diets. The phytase supplement contained 50 phytase units/g and 1.43% P. In Exp. 1, growing-finishing pigs were fed fortified corn-soybean meal diets formulated to be adequate (.50%) or inadequate (.30%) in P during the growing phase (38 to 57 kg BW) followed by adequate (.40%) or inadequate (.30%) P, respectively, during the finishing phase (to 101 kg BW). Dicalcium phosphate was the source of supplemental P. Half the diets were supplemented with phytase at 500 phytase units/kg. Rate and efficiency of gain and bone breaking strength were decreased (P < .01) when the low-P diet was fed. Adding phytase to the low-P diet restored performance and bone breaking strength (P < .01) to levels that approached those of pigs fed the adequate-P diet. In Exp. 2, growing pigs (13 kg BW), were fed a low-P (.32% total P; .048% available P) based diet supplemented with graded levels of monosodium phosphate to provide 0, .075, and .15% added P or with phytase to supply 250, 500, 1,000, or 2,000 phytase units/kg. Chromic oxide was included as an indigestible marker for determining apparent absorption and fecal excretion of P. Performance and bone strength increased linearly with added monosodium phosphate (P < .01) and with increasing levels of supplemental phytase (P < .05). A portion of these increases from phytase was attributed to the P supplied by the phytase mix (.007, .014, .028, .057%, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Luciferins Behave Like Drugs

The light emission chemistry of firefly luciferase can be harnessed to reveal otherwise invisible biological processes occurring in the brains of live animals. Though powerful, the need for the luciferase substrate D-luciferin to traverse the blood-brain barrier poses limitations on the sensitivity and interpretation of these experiments. In this Viewpoint, we discuss bioluminescent imaging probes for the enzyme fatty acid amide hydrolase (FAAH) and the broader implications for optical imaging and drug delivery in the brain.
Participation in sports activities and suicidal behaviour: A risk or a protective factor?

In order to study whether participation in sports has a protective impact on suicidal behaviour in students, the data from 11 Youth Risk Behavior Surveys were combined providing a sample size of 152,858 students. The results indicated that sports participation was a protective factor against suicidal behaviour for European-American boys and girls. However, for African-American, Hispanic-American and Asian-American girls, participation in sports might be a risk factor for suicidal ideation and suicide attempts. For boys from minority ethnic groups, participation in sports was not associated with suicidal behaviour.
Extrahepatic metastasectomy for hepatocellular carcinoma: Predictors of long-term survival.

Introduction We report our institutional experience with extrahepatic metastasectomy (EM) in a cohort of hepatocellular carcinoma (HCC) patients with focus on predictors of survival. Methods All patients diagnosed with metastatic HCC from 2001 to 2014 were retrospectively reviewed to identify those who underwent EM with therapeutic intent. Associations among multiple clinicopathological variables and survival after EM were analyzed by univariate and multivariate analyses. Results Out of 440 metastatic HCC cases, we identified 85 patients (mean age 58.8 ± 11.7 years, 81.2% males) who underwent lung (n = 36), peritoneal (n = 22), lymph node (n = 19), musculoskeletal (n = 18), and adrenal (n = 9) metastasectomy. Most patients (84.7%) underwent metachronous EM following primary liver resection or transplantation. The median follow-up period was 20.9 months, during which 55 patients (64.7%) died. The 1-/2-/5-year overall survival rates after EM were 77.4, 53.1, and 25.1%, respectively. On multivariate analysis, number of metastases resected >2 correlated independently with poor survival (HR = 2.058, P = 0.0099). EM patients had superior median survival compared to all (n = 194) metastatic HCC patients treated with sorafenib without EM during the study period (27.2 vs. 7.4 months, P < 0.001). Conclusion Long-term survival may be achieved in highly selected HCC patients following EM. The presence of greater than two extrahepatic lesions correlates independently with poor survival. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc.
United States v. Textron: The Right Answer to a Billion-Dollar Question

Table of ContentsI. Introduction 1974II. What Are Tax Accrual Workpapers? 1981III. The Work Product Doctrine 1984A. The Meaning of "in Anticipation of Litigation" 19871. The Temporal Component 19882. The Motivational Component 1990B. The Motivational Component Circuit Split 19901. The "Primary Purpose Test" and£7 Paso 19912. The "Because of Test and Adlman 19943. The Alleged "For Use" Test and Textron 1998IV. United States v. Textron 1999A. The Majority Opinion 2002B. The Dissenting Opinion 2003V. Analysis of the Textron Opinion 2006A. The Dissent Reached the Wrong Decision 20061 . The Dissent Failed to Raise Legitimate Concerns 20062. The Dissent Incorrectly Applied the "Because of Test 20103 . The Dissent Erroneously Concluded that Adlman Is "Fatal" to the Majority Opinion 2012B. The Majority Ultimately Reached the Right Decision ........ 20151 . The Majority's Analysis Welcomed Criticism and "For Use" Test Speculation 20152. The Majority Correctly Applied the "Because of Test 2017VI. Tax Accrual Workpapers Do Not Deserve Work Product Protection 2020A. Tax Accrual Workpapers Are Produced in the Ordinary Course of Business 2020B. Litigation Is Too Remote to Be Reasonably Anticipated 2023C. An IRS Audit and Subsequent Proceedings Do Not Qualify as Litigation 2024D. Public Policy Favors Compliance and the Exposure of Tax-Sheltering Activities 2027E. The LRS Has a Substantial Need for Tax Accrual Workpapers 2030VII. Conclusion 2033I. IntroductionDespite the general understanding that paying taxes is fundamental to a functioning democracy,1 Americans continue to debate who should in fact pay them, and how much.2 Passionate debate concerning what the law should be is a healthy aspect of democratic society.3 But noncompliance with established tax law challenges the legitimacy of our government.4 The unwillingness of both citizens and corporations to pay their taxes in full and on time is cause for concern.5In February 2006, the Internal Revenue Service (IRS) reported that the deficit tax gap in 2001 was approximately $350 billion, which reflected a compliance rate of 83.7%.6 Over 15% of U.S. taxpayers failed to pay their taxes in full, which "creates public cynicism in the fairness and effectiveness of our voluntary compliance system."7 Despite declarations of Congress to remedy the problem,8 the tax gap in America remains an unresolved issue. …
Seven Wonders of the World of Enzymes

The enzymes in our cells perform a bewildering variety of tasks. Some of these tasks, such as the cleavage reaction performed by lysozyme, are simple enough that a standard protein, composed of the normal 20 amino acids, will suffice. In other cases, however, the reaction may be too difficult, or too sensitive to the surrounding environment, or too dangerous to the cell to be performed by a typical enzyme, and cells have evolved many wondrous specializations in their enzymes to perform these tasks as needed. In this chapter, I have selected seven aspects of enzyme action that I find most amazing. But you only need to look to Nature to find many additional wonders.
Methods to Improve Sustainability of a Large Academic Biorepository

This article discusses the evolution of the University of Pittsburgh (UPitt) Health Sciences Tissue Bank (HSTB) operation and how it has successfully positioned itself, manages to sustain its value, and remains viable in today's research landscape. We describe the various components of our biobanking operation, which are valued by our researchers, thus leading to sustainability for our biorepository. Operating within the infrastructure of a large academic university, we have access to the most cutting-edge database resources for collecting, tracking, and annotating thousands of specimens. We are constantly improving upon our ability to provide real-time longitudinal follow-up data for our collections, thus providing researchers with valuable, highly annotated research specimens. We believe the combination of all that is described within this article helps to create a biobank that will remain sustainable well into the future.
Monitoring Maturation in Chinese Financial Intermediation

Over the four decades since the Four Modernizations program began in 1978, China has matured from a capital-starved, mono-bank-centric financial system to a capital-rich system with great variety of financial intermediation. This chapter plays off the double meaning of its title: first, it monitors the maturation in Chinese financial intermediation. Surveying development of financial intermediation in China, this chapter considers the social responsibility of financial intermediaries to monitor financial contracts and how intermediaries overcome financial market inefficiencies by acting as information conduits. Effective monitoring of financial contracts delivers both benefits. Secondly, it examines the maturation of the monitors themselves, in particularly those involved within the SME sector. The chapter employs the case of Wenzhou’s financial networks- highly-localized yet also the center of pan-China network of folk-lending. Financial innovation is causing a shift in SME lending from so-called folk-lending to peer-to-peer on-line lending, but monitoring in financial intermediation lags behind innovation.
Baseline Sensitivity of Fusarium virguliforme to Fluopyram Fungicide.

Fluopyram, a succinate dehydrogenase inhibitor (SDHI) fungicide, was recently registered for use as a soybean seed treatment for management of sudden death syndrome (SDS) caused by Fusarium virguliforme. Although registered and now used commercially, in vitro baseline fungicide sensitivity of F. virguliforme to fluopyram has not yet been established. In this study, the baseline sensitivity of F. virguliforme to fluopyram was determined using in vitro growth of mycelium and germination of conidia assays with two collections of F. virguliforme isolates. A total of 130 and 75 F. virguliforme isolates were tested using the mycelial growth and conidia germination assays, respectively, including a core set of isolates that were tested with both assays. In the mycelial growth inhibition assay, 113 out of 130 isolates (86.9%) were inhibited 50% by effective concentrations (EC50) less than 5 µg/ml with a mean EC50 of 3.35 µg/ml. For the conidia germination assay, 73 out of 75 isolates (97%) were determined to have...
From planar boron clusters to borophenes and borospherenes

Photoelectron spectroscopy in combination with computational chemistry has been used over the past decade to systematically elucidate the structures and chemical bonding of sizeselected boron clusters. Small boron clusters have been found to be planar or quasi-planar with both delocalized σ and π bonding. A particularly interesting cluster is B 36 , which has been found to possess a planar structure with a central hexagonal vacancy. The hexagonal B 36 can be viewed as a repeating unit to assemble atom-thin boron monolayers (dubbed borophenes). This finding provides the first indirect experimental evidence that borophenes with hexagonal vacancies are potentially viable. Another exciting discovery has been the observation and characterization of the first all-boron fullerenes. Photoelectron spectroscopy revealed that the B 40 − cluster consisted of two isomers with very different electron binding energies. Global minimum searches led to two nearly degenerate isomers competing for the global minimum: a quasi-planar isomer and an unprecedented cage isomer. In the neutral, the B 40 cage is overwhelmingly the global minimum, which is the first all-boron fullerene to be observed and is named “borospherene”. There is evidence that there exists a family of borospherenes with B 28 being the smallest borospherene. It is expected that the pace of discovery will continue to accelerate in boron clusters, and more interesting structures and chemical bonds will be uncovered with heightened research interests and more sophisticated experimental and computational methods.
Self‐regulating ubiquitin ligases

Occasional auto‐modification of ubiquitin ligases typically leads to their proteasomal destruction, but new findings published in The EMBO Journal now show that in the case of Rsp5/Nedd4, auto‐ubiquitylation instead triggers oligomerization and concomitant reduction of ligase activity. This novel mechanism therefore creates silenced ligases that remain poised for reactivation.
Synthesis, Characterization, Electrical and Photocatalytic Studies of Polyacrylamide Zr(IV) Phosphosulphosalicylate, a Cation Exchanger: Its Application in the Removal of Hg (II) from Aqueous Solution

In this work, we synthesized successfully a new organic–inorganic material, polyacrylamide Zr(IV) phosphosulphosalicylate (PAAZPSS) by simple sol–gel method and converted in a cation exchanger and then applied as an adsorbent for the removal of Hg (II) from aqueous solution. In order to confirm the desired synthesis, the prepared material was characterized by many sophisticated techniques such as FTIR, SEM and XRD. The ion exchange adsorbent exhibits good ion exchange capacity (IEC) for alkali metal ion (\(\hbox {K}^{+})\). Selective studies of this ion exchange adsorbent for different metal ions were performed, and on the basis of \({K}_{\mathrm{d}}\) values PAAZPSS was more selective for Hg (II). The sorption experiment for the Hg (II) removal was performed using batch method. The adsorption process followed Langmuir adsorption isotherm and pseudo-second-order kinetic model. The thermodynamic parameters revealed the feasibility, spontaneity, endothermic nature of the PAAZPSS-Hg (II) system. The material showed high value of dielectric constant, dielectric loss at low-frequency region and enhanced AC conductivity at low-frequency region so it can be used in energy storage devices. The material also showed good photocatalytic degradation of rhodamine B and crystal violet dyes. So it may be concluded that polyacrylamide Zr(IV) phosphosulphosalicylate can be employed not only for the treatment of inorganic metal ion and photocatalytic degradation of organic dyes but also in electrical application.
Abstract 2159: A specific 17-beta-hydroxywithanolide (LG-02) sensitizes cancer cells to apoptosis in response to TRAIL and TLR3 ligands

Recent studies have demonstrated a role of toll-like receptor 3 (TLR3) signaling for the initiation of apoptosis in some malignant cells. We have previously shown that, withanolide E (WE), a 17β-hydroxywithanolide (17-BHW) natural product derived from the medicinal plant Physalis peruviana was capable of sensitizing tumor cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by reducing cellular levels of the anti-apoptotic protein cFLIP. Animal studies also revealed that WE sensitized human renal carcinoma cells to apoptosis at concentrations that did not promote apoptosis in normal cells. Thus we further screened a library of 30 natural and semi-synthetic 17-BHWs for their ability to promote death ligand-mediated cancer cell death. Among the 30 compounds tested, LG-02 (physachenolide C) was found to be 4-5 fold more potent than WE in sensitizing some human renal carcinoma and melanoma cells to apoptotic cell death in response not only to TRAIL but also to the synthetic polynucleotide poly (I:C), which is known to mimic anti-viral responses by activating TLR3 signaling. To date there are no withanolides known to have this dual apoptosis sensitizing activity. LG-02 and Poly (I:C) treatment resulted in increased activation of caspase-8, and apoptosis was blocked by the pan caspase inhibitor zVAD-FMK. Poly (I:C)-driven apoptosis signaling was dependent on endosomal acidification, but independent of IRF 3 and Interferon α/β signaling. Molecular studies suggested a role for changes in the anti-apoptotic proteins cFLIP, IAPs, and Livin on apoptosis signaling in LG-02 treated cells. Loss of cIAP activity is reported to promote spontaneous formation of an intracellular death-inducing protein platform the ripoptosome, that can activate either apoptosis or necroptosis. Immunoprecipitation of either the TRAIL death-inducing signaling complex (DISC) or the Poly (I:C) ripoptosome, demonstrated enhanced levels of FADD and RIP1 and decreased levels of cFLIP in these macromolecular apoptosis signaling complexes in LG-02 treated cells. Intratumor administration of LG-02 and Poly (I:C) in a xenograft M14 melanoma model provided therapeutic benefit leading to complete tumor regression in 90 % of the mice as compared to control mice. Further studies with active 17-BHWs could lead to the identification of more potent analogues, and novel and common therapeutic targets involved in apoptosis signaling in response to both TNF death receptor family members as well as TLR3 ligands.Funded by FNLCR Contract HHSN261200800001E Citation Format: Poonam Tewary, Alan D. Brooks, Ya-ming Xu, Kithsiri E.M Wijeratne, Leslie A. Gunatilaka, Thomas J. Sayers. A specific 17-beta-hydroxywithanolide (LG-02) sensitizes cancer cells to apoptosis in response to TRAIL and TLR3 ligands [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2159. doi:10.1158/1538-7445.AM2017-2159
Fault isolation of digital scan logic without ‘scan diagnosis’

Software scan diagnosis has been the de facto approach to narrow down possible defect locations in logic circuits by virtue of its speed and effectiveness. However, this capability is not supported for all product yield engineering and custom electrical failure analysis is naturally relied on. By this approach, unless the defects are gross, fault localization of internal logical nodes can be challenging and this directly impacts product yield ramp and time-to-market. This paper describes and demonstrates three effective methods leveraging pre-diagnostic test data and a combination of dynamic EFI techniques, as viable alternatives to scan diagnosis. Case examples will be presented.
Neighborhood Preservation and Community Values in Historical Perspective

The scene could be suburbia anywhere: the neat, ranch-style homes surrounded by white picket fences, doors bedecked in wreaths heralding the Christmas season, the toys of summer—a boat, a bicycle, a grill—huddled in corners of back yards. If the scene is familiar, however, the location is not. This is the South Bronx, one of the most notorious physical and human wastelands in the nation, an obligatory station for politicians taking a pilgrimage to discover and expose poverty and urban decay. To casual observers, the scene in this ninety-home development known as Charlotte Gardens is bizarre; to residents it is the fulfillment of their American dream of a single-family home even if Times Square is only a short, twenty-minute subway ride away. The three-bedroom homes that sell for a modest $52,000 have a long waiting list of hopeful buyers. Fortunate residents enthused about their new environment. “I always dreamed of having my own private house,” Deloris Deleston confessed. Her neighbor, Julio Cruz remarked that “It’s not like living in an apartment where you don’t know your next-door neighbor.” And twelve-year old Melody Sellers noted that “In the summertime, it’s like the country.” (“Community of Delight,” 1984, p. 3)
Foreign Judges and the Emergence of a Tanzanian Judiciary, 1964–1971

This chapter examines the period following the departure of the colonial judges when the Tanzanian government appointed both foreign and local judges to the High Court Bench and magistracy. It argues that foreign judges from West Africa and the West Indies served as a stepping stone between a colonial Bench and a local one. It explores their position in the new nation and responses to early executive encroachment on the independence of the judiciary. This chapter also analyses the backgrounds and experiences of the first Tanganyikan African judges, including those who were trained abroad and at the Faculty of Law in Dar es Salaam. It asserts that the process of decolonising the Bench concluded in 1971 with the appointment of the first Tanganyikan African Chief Justice.
Benchmarking deep learning trackers on aerial videos

In this paper, we benchmark five state-of-the-art trackers on aerial platform videos: Multi-domain Convolutional Neural Network (MDNET) tracker, which was the winner of the VOT2015 tracking challenge, the Fully Convolutional Neural network Tracker (FCNT), the Spatially Regularized Correlation Filter (SRDCF) tracker, the Continuous Convolution Operator Tracker (CCOT) tracker, which was the winner of the VOT2016 challenge, and the Tree structure Convolutional Neural Network (TCNN) tracker. We assess performance in terms of both tracking accuracy and processing speed based on two sets of videos: a subset of the OTB dataset where the cameras are located at a high vantage point and a new dataset of aerial videos captured by a moving platform. Our results indicate that these trackers performed as expected for the videos in the OTB subset, however, tracker performance degraded significantly in aerial videos due to target size, camera motion and target occlusions. The CCOT tracker yielded the best overall performance in terms of accuracy, while the SRDCF tracker was the fastest.
ANALISIS KINERJA KEUANGAN PERUSAHAAN MENGGUNAKAN METODE ECONOMIC VALUE ADDED (EVA) DENGAN MICROSOFT VISUAL BASIC

Competition is increasingly competitive business world in all fields require firms to further improve its performance. Economic Value Added (EVA) is one appropriate method for measuring a company's financial performance. Company's financial performance is the company's achievements in the transaction or the business as measured by capital adequacy, liquidity and profitability. EVA aims to assess the financial performance of companies that are indicators of the addition of the value of an investment in the form of income and value-based. EVA is useful for measuring the performance of a company that can stand alone without the need for other measures in the form of comparisons with similar companies or to analyze the trend (trend). One of the advantages of EVA is used as the basis for assessment of bonuses to employees, especially in the division that provides EVA is more that can be said that the EVA running stakeholders satisfaction concepts. The disadvantage of EVA are based on the belief that investors rely heavily on fundamental approach in reviewing and making decisions to buy and sell particular stocks. With the tool (tools) Ms. Visual Basic Programming, analysis of company financial performance using Economic Value Added (EVA) can more quickly and accurately.
Early Predictors of the Need for Emergent Surgery to Control Hemorrhage in Hypotensive Trauma Patients

Twenty-five to 30 per cent of hypotensive trauma patients require an emergent surgery, however, we have no reliable means to quickly determine that need. Our goal was to determine, via retrospective review, parameters available within minutes of arrival that predict the need for emergent surgery to control hemorrhage in hypotensive trauma patients. Inclusion criterion was initial systolic blood pressure (SBP) < 90 mm Hg in the emergency department (ED). Patients who were dead on arrival or underwent ED thoracotomy were excluded. Emergent surgery was defined as sternotomy, thoracotomy, laparotomy, or major neck vascular repair on day of admission. Potential clinical predictors were analyzed in a binary logistic regression model. Six hundred and thirty-nine hypotensive patients were identified and 193 excluded, leaving 446 with a mean age of 33 +/- 19 years and Injury Severity Score of 22 +/- 17. Thirty-two per cent suffered penetrating trauma, 30 per cent needed emergent surgery, and 19 per cent died. Independent predictors were: prolonged extrication (odds ratio (OR) 2.3), no loss of consciousness (OR 2.8), intubation (OR 1.7), central line placement (OR 1.7), and blood transfusion (OR 2.1, all P < 0.05). We concluded that hypotensive trauma patients without head injuries who require prolonged extrication, intubation, central venous access, and blood transfusion in the ED are more likely to need emergent surgery.
Oral Administration of Peptides: Bypassing a Hostile Milieu

As a peptide drug passes through the alimentary canal it runs the gauntlet of hostile environments. These include the very acid pH of the stomach, the secreted proteolytic enzymes in the stomach and small intestine, the cell-membrane-bound enzymes of the brush border of the small intestine, and the host of bacterial enzymes that may be liberated in the colon. Of these, the proteolytic enzymes of pancreatic origin in the small intestine, trypsin and chymotrypsin, are the most powerful destructive agents.
Computational design of chemogenetic and optogenetic split proteins

Controlling protein activity with chemogenetics and optogenetics has proven to be powerful for testing hypotheses regarding protein function in rapid biological processes. Controlling proteins by splitting them and then rescuing their activity through inducible reassembly offers great potential to control diverse protein activities. Building split proteins has been difficult due to spontaneous assembly, difficulty in identifying appropriate split sites, and inefficient induction of effective reassembly. Here we present an automated approach to design effective split proteins regulated by a ligand or by light (SPELL). We develop a scoring function together with an engineered domain to enable reassembly of protein halves with high efficiency and with reduced spontaneous assembly. We demonstrate SPELL by applying it to proteins of various shapes and sizes in living cells. The SPELL server (spell.dokhlab.org) offers an automated prediction of split sites.
High-precision potassium isotopic analysis by MC-ICP-MS: an inter-laboratory comparison and refined K atomic weight

In the last a few years, several groups proposed new methods of high-precision K isotope analysis using Multiple Collector Inductively Coupled Plasma Mass Spectrometer (MC-ICP-MS) either through “collision gas” or “cold plasma” methods. Here we report a detailed method analyzing K isotopes in high-precision using Neptune Plus MC-ICP-MS in cold plasma and conduct an inter-laboratory comparison. The precision of measurements of 41K/39K ratios of a single run in this study can routinely reach ∼0.05 per mil (95% confidence interval; n = 10). The long-term (20 months) robustness and reproducibility of this method have also been evaluated (0.11 per mil; 2 standard deviation; n = 890). We also report K isotopic compositions of 20 geological reference materials and compare this method with recent methods from other laboratories. These independent measurements of the same reference materials agree well with each other within reported analytical uncertainties. Because of the newly improved methods and observed K isotopic fractionation among reference materials, the International Union of Pure and Applied Chemistry (IUPAC) recommended values for the weight of potassium and the atomic fractions of K isotopes need to be revised.
What’s Wrong with Us? Sexual Misconduct and the Discipline of Political Science

Sexual misconduct matters not only when it is perpetuated by political actors in political institutions. It matters wherever it happens and whomever it happens to, because it is, at its base, polit...
Benchmarking and Implementation of Probability-Based Simulations on Programmable Graphics Cards

The latest Graphics Processing Units (GPUs) are reported to reach up to 200 billion floating point operations per second (200 Gflops) and to have price performance of 0.1 cents per M flop. These facts raise great interest in the plausibility of extending the GPUs' use to non-graphics applications, in particular numerical simulations on structured grids (lattice). We review previous work on using GPUs for non-graphics applications, implement probability-based simulations on the GPU, namely the Ising and percolation models, implement vector operation benchmarks for the GPU, and finally compare the CPU's and GPU's performance. A general conclusion from the results obtained is that moving computations from the CPU to the GPU is feasible, yielding good time and price performance, for certain lattice computations. Preliminary results also show that it is feasible to use them in parallel
Hangers, Potions, and Pills: Abortion Procedures on American Television, 2008 to 2018

Abstract Background Television portrayals of medical procedures may contribute to patient anxieties and cultural myths. We explored how television depicts abortion procedures, focusing on what these portrayals communicate about abortion access and safety. Methods Researchers identified all abortion procedure plotlines on American television from 2008 to 2018 through Internet searches. We viewed plotlines and coded for type of abortion, health outcome, and whether the abortion occurred on or off screen. We used inductive content analysis to identify themes. Findings We identified 96 television plotlines between 2008 and 2018 in which a character obtains or discloses an abortion. Of these, 39 plotlines (40%) depict some aspect of the abortion procedure. Twenty-three of the 39 abortion portrayals (59%) depict a surgical abortion procedure, of which about one-half were legal abortions and one-half were illegal. Only 7 of the 39 procedure plotlines (18%) portray medication abortions. Five of these plotlines depict illegal abortions; only two depict legal abortions. Four plotlines depict attempted abortions by supernatural means or ingestion of a toxic liquid. Conclusion The majority of abortions on television are surgical, contrasting with the reality of abortion practice in which one-third of U.S. abortions are by medication. Portrayals of surgical abortion often reinforce the misperception that abortion is a surgical intervention requiring hospitalization. The few portrayals of medication abortion also perpetuate inaccuracies, including that it is easily accessible, uncommon, and dangerous. Portrayals of illegal abortions are overrepresented. This misinformation may seed unnecessary fear for patients before an abortion, and may create confusion among the public about abortion access and safety.
Déjà Vu All Over Again: Trends in Flood Drivers Point to Continuing Vulnerability

iStock/ChrisBoswellThe scale of the 1993 floods stunned the nation, spreading across nine states in the Midwest and affecting tens of thousands. By the time the waters had receded, more than $37 bi...
Active Variable Reactance Rectifier—A New Approach to Compensating for Coupling Variations in Wireless Power Transfer Systems

This article introduces a new approach to compensate for coupling variations in wireless power transfer (WPT) systems by utilizing an active variable reactance (AVR) rectifier. The AVR rectifier operates at a fixed frequency and incorporates a power-splitting resonant network. By controlling the ratio of the split powers in its branches, the AVR rectifier continuously compensates for large misalignments and distance variations between couplers, while maintaining full power transfer. A comprehensive methodology is presented that maximizes the tolerable range of misalignments in an AVR-rectifier-enabled capacitive WPT system while meeting efficiency targets. The proposed approach is validated using a 13.56-MHz, 300-W, 12-cm nominal air-gap prototype capacitive WPT system, which incorporates an AVR rectifier and can be scaled up in power for dynamic electric vehicle (EV) charging applications. The prototype system maintains full power transfer for up to 45% lateral misalignment in the coupler and up to 45% increase in the vehicle’s road clearance. In a dynamic EV charging scenario, the AVR-rectifier-enabled system transfers 80% more energy during a single pass of the vehicle over the charging pad, as compared to a system without the AVR rectifier. The measured performance of the prototype system is in good agreement with predictions.
Summer School for Middle School Readers Labeled as Struggling: Lessons Learned and Pathways Forward

The decline of academic achievement during summer is well documented and can result in a one-month loss of skills acquired during the school year. Summer slide can further contribute to a widening ...
How individual ethical frameworks shape physician trainees' experiences providing end-of-life care: a qualitative study

Objectives The end of life is an ethically challenging time requiring complex decision-making. This study describes ethical frameworks among physician trainees, explores how these frameworks manifest and relates these frameworks to experiences delivering end-of-life care. Design We conducted semistructured in-depth exploratory qualitative interviews with physician trainees about experiences of end-of-life care and moral distress. We analysed the interviews using thematic analysis. Setting Academic teaching hospitals in the United States and United Kingdom. Participants We interviewed 30 physician trainees. We purposefully sampled across three domains we expected to be associated with individual ethics (stage of training, gender and national healthcare context) in order to elicit a diversity of ethical and experiential perspectives. Results Some trainees subscribed to a best interest ethical framework, characterised by offering recommendations consistent with the patient’s goals and values, presenting only medically appropriate choices and supporting shared decision-making between the patient/family and medical team. Others endorsed an autonomy framework, characterised by presenting all technologically feasible choices, refraining from offering recommendations and prioritising the voice of patient/family as the decision-maker. Conclusions This study describes how physician trainees conceptualise their roles as being rooted in an autonomy or best interest framework. Physician trainees have limited clinical experience and decision-making autonomy and may have ethical frameworks that are dynamic and potentially highly influenced by experiences providing end-of-life care. A better understanding of how individual physicians’ ethical frameworks influences the care they give provides opportunities to improve patient communication and advance the role of shared decision-making to ensure goal-aligned end-of-life care.
Head and shoulders: not just a flaky pattern

This paper evaluates rigorously the predictive power of the head-and-shoulders pattern as applied to daily exchange rates. Though such visual, nonlinear chart patterns are applied frequently by technical analysts, our paper is one of the first to evaluate the predictive power of such patterns. We apply a trading rule based on the head-and-shoulders pattern to daily exchange rates of major currencies versus the dollar during the floating rate period (from March 1973 to June 1994). We identify head-and-shoulders patterns using an objective, computer-implemented algorithm based on criteria in published technical analysis manuals. The resulting profits, replicable in real-time, are then compared with the distribution of profits for 10,000 simulated series generated with the bootstrap technique under the null hypothesis of a random walk.
A Computational Introduction to Number Theory and Algebra

This introductory book emphasizes algorithms and applications, such as cryptography and error correcting codes, and is accessible to a broad audience. The presentation alternates between theory and applications in order to motivate and illustrate the mathematics. The mathematical coverage includes the basics of number theory, abstract algebra and discrete probability theory. This edition now includes over 150 new exercises, ranging from the routine to the challenging, that flesh out the material presented in the body of the text, and which further develop the theory and present new applications. The material has also been reorganized to improve clarity of exposition and presentation. Ideal as a textbook for introductory courses in number theory and algebra, especially those geared towards computer science students.
Morphological structuring function decomposition

The author attempts to solve the structuring function decomposition problem where the structuring function refers to the gray scale structuring element. A morphologically realizable representation for the structuring function that reduces the structuring function decomposition into a series of binary structuring element decompositions is presented. Recursive algorithms that are pipelinable for efficiently performing gray scale morphological operations are developed on the basis of proposed representation and decomposition. The results are beneficial to real-time image analysis in terms of computer architecture and software development. >
The Structure and Interpretation of Imperatives: Mood and Force in Universal Grammar

Preface 1. Introduction Issues and Sketch of the Proposal Theoretical Background Outline of the Book Notes 2. Cross-linguistic Variation in the Compatibility between Imperatives and Negation Introduction Data and Issues Previous Studies A Puzzle Posed by the Clitic-like Nature of Negation The Locus of Imperative Operator: C sub 0 Proposal Apparent Counterexamples Suppletion and Negative Commands Conclusion Notes 3. The Syntactic Evolution of the English Imperative Introduction Data and Issues Infinitivals in Middle English The Development of Do-support in Imperatives Sequential Loss of Verb Movement No Do-support in Infinitivals and Subjunctives Conclusion Appendix Notes. 4. Feature Content of the Imperative Operator Introduction Feature Content of Imperative Operator Subjunctives and Infinitivals with Directive Function The Subjects of Imperatives Conclusion Notes 5. Interpreting Imperatives: The Contribution of Mood and Force Introduction Logical Form of Imperatives Consequences Imperatives in Discourse Conclusion Notes
Early detection of skin cancer: Racial/ethnic differences in behaviors and attitudes

Data from 384 individuals participating in a worksite skin cancer screening program were used to assess racial/ethnic differences in attitudes toward and practice of prevention and early detection of skin cancer. Caucasians and Hispanics were more likely than African Americans to report having used a sunscreen during the past year. Caucasians performed skin self-examination more frequently than Hispanics, but African Americans did not differ in their frequency of skin self-examination from the other two groups. African Americans and Hispanics reported that they would be less likely than Caucasians to seek immediate follow-up care for suspicious skin lesions. Both similarities and differences were found in a variety of health belief variables across the three groups. These findings suggest a need for intensified efforts at primary and secondary prevention of skin cancer among African Americans.
Negative methacholine challenge tests in subjects who report physician-diagnosed asthma.

Summary Background The frequency of adults reporting a history of asthma is rising. However, it is unclear whether this increased prevalence accurately demonstrates a rising trend or if it reflects an overall increase in asthma awareness. Objective To determine the frequency of negative methacholine bronchoprovocation tests in adults who report physician-diagnosed asthma and to explore the clinical characteristics of subjects with negative tests. Methods Data from methacholine challenge, spirometry, and physician assessment were analysed from 304 adults who reported physician-diagnosed asthma and responded to community-based advertising for asthma research studies. The clinical characteristics of methacholine-positive and -negative subjects were compared and a predictive model was tested to identify those characteristics associated with a negative test. Results Of the 304 subjects tested, 83 (27%) had a negative methacholine test. A negative test was positively associated with an adult-onset of symptoms (P<0.001), normal forced expiratory volume in 1 s (P<0.001), and having no history of exacerbation requiring oral steroids (P=0.03). Over half (60%) of those with a negative test reported weekly asthma-like symptoms (cough, dyspnoea, chest tightness, or wheeze), while 39% reported emergency department visits for asthma-like symptoms. Conclusions and clinical relevance A sizeable percentage of subjects who report physician-diagnosed asthma have a negative methacholine challenge test. These subjects are characterized by diagnosis of asthma as an adult and by normal or near normal spirometry. Caution should be exercised in the assessment and diagnosis of adults presenting with asthma-like symptoms, because they may not have asthma. Further diagnostic studies, including bronchoprovocation testing, are warranted in this patient group, especially if their spirometry is normal. Cite this as: K. W. McGrath and J. V. Fahy, Clinical & Experimental Allergy, 2011 (41) 46–51.