cssi/SciSciGPT-SciSciNet huggingface dataset:
H9, H10, and H11 compose a cluster of Hessian fly-resistance genes in the distal gene-rich region of wheat chromosome 1AS

H9, H10, and H11 are major dominant resistance genes in wheat, expressing antibiosis against Hessian fly [(Hf) Mayetiola destructor (Say)] larvae. Previously, H9 and H10 were assigned to chromosome 5A and H11 to 1A. The objectives of this study were to identify simple-sequence-repeat (SSR) markers for fine mapping of these genes and for marker-assisted selection in wheat breeding. Contrary to previous results, H9 and H10 did not show linkage with SSR markers on chromosome 5A. Instead, H9, H10, and H11 are linked with SSR markers on the short arm of chromosome 1A. Both H9 and H10 are tightly linked to flanking markers Xbarc263 and Xcfa2153 within a genetic distance of 0.3–0.5 cM. H11 is tightly linked to flanking markers Xcfa2153 and Xbarc263 at genetic distances of 0.3 cM and 1.7 cM. Deletion bin mapping assigned these markers and genes to the distal 14% of chromosome arm 1AS, where another Hf-resistance gene, Hdic (derived from emmer wheat), was also mapped previously. Marker polymorphism results indicated that a small terminal segment of chromosome 1AS containing H9 or H10 was transferred from the donor parent to the wheat lines Iris or Joy, and a small intercalary fragment carrying H11 was transferred from the resistant donor to the wheat line Karen. Our results suggest that H9, H10, H11, Hdic, and the previously identified H9- or H11-linked genes (H3, H5, H6, H12, H14, H15, H16, H17, H19, H28, and H29) may compose a cluster (or family) of Hf-resistance genes in the distal gene-rich region of wheat chromosome 1AS; and H10 most likely is the same gene as H9.
Etherification of aldehydes, alcohols and their mixtures on Pd/SiO2 catalysts

Dialkyl ethers have been selectively produced from etherification of aldehydes and alcohols on supported Pd catalysts. A yield of 79% ether with a selectivity of 90% was observed when feeding 2-methylpentanal with 2-methylpentanol at a molar ratio 1:1 at 125 ◦ C. Cross etherification of n-butanol with 2-methylpentanal shows a much higher rate than that observed when the alcohol or aldehyde is fed alone. This enhanced activity is in line with the catalyst requirement for large ensembles that allow surface alkoxide species next to 2 adsorbed aldehydes. Etherification when only aldehyde or alcohol is fed arises predominantly due to aldehyde–alcohol inter-conversion to produce the necessary co-reactant. The ether yield at the same reaction conditions decreases with metal loading in the order 16 > 10 > 3 wt.% Pd. Increasing reduction temperature also increases ether yield. It is apparent that etherification is highly sensitive to metal particle morphology, consistent with needing ensembles that accommodate the two adjacent adsorption sites.
25 YEARS OF BROMINE CHEMISTRY IN INDUSTRIAL WATER SYSTEMS: A REVIEW

Bromine chemistry is used to great advantage in nature for fouling control by a number of sessile marine organisms such as sponges, seaweeds, and bryozoans. Such organisms produce small quantities of brominated organic compounds that effectively help keep their surfaces clean of problem bacteria, fungi, and algae. For over two decades, bromine chemistry has been used to similar advantage in the treatment of industrial water systems. The past several years in particular has seen the development of several diverse bromine product forms – one-drum stabilized bromine liquids, all-bromine hydantoin solids, and pumpable gels. The purpose of this paper is to review the development of bromine chemistry in industrial water treatment, discuss characteristics of the new product forms, and speculate on future developments.
ANALYZING THE ROLE OF VISUAL STRUCTURE IN THE RECOGNITION OF NATURAL IMAGE CONTENT WITH MULTI-SCALE SSIM

Natural images are meaningful to humans — the physical world exhibits statistical regularities that permit the human visual system (HVS) to infer useful interpretations. These regularities communicate the visual structure of the physical world and govern the statistics of images (image structure). A signal processing framework is sought to analyze image characteristics for a relationship with human interpretation. This work investigates the first step toward an objective visual information evaluation: predicting the recognition threshold of different image representations. Given a image sequence, whose images begin as unrecognizable and are gradually refined to include more information according to some measure, the recognition threshold corresponds to first the image in the sequence in which an observer accurately identifies the content. Sequences are produced using two types of image representations: signal-based and visual structure preserving. Signal-based representations add information as dictated by conventional mathematical characterizations of images based on models of low-level HVS processing and use basis functions as the basic image components. Visual structure preserving representations add information to images attributed to visual structure and attempt to mimic higher-level HVS processing by considering the scene’s objects as the basic image components. An experiment is conducted to identify the recognition threshold image. Several full-reference perceptual quality assessment algorithms are evaluated in terms of their ability to predict the recognition threshold of different image representations. The cross-correlation component of a modified version of the multi-scale structural similarity (MS-SSIM) metric, denoted MS-SSIM*, exhibits a better overall correlation with the signal-based and visual structure preserving representations’ average recognition thresholds than the standard MS-SSIM cross-correlation component. These findings underscore the significance of visual structure in recognition and advocate a multi-scale image structure analysis for a rudimentary evaluation of visual information.
Dysregulated T cell expression of TIM3 in multiple sclerosis

T cell immunoglobulin- and mucin domain–containing molecule (TIM)3 is a T helper cell (Th)1–associated cell surface molecule that regulates Th1 responses and promotes tolerance in mice, but its expression and function in human T cells is unknown. We generated 104 T cell clones from the cerebrospinal fluid (CSF) of six patients with multiple sclerosis (MS) (n = 72) and four control subjects (n = 32) and assessed their cytokine profiles and expression levels of TIM3 and related molecules. MS CSF clones secreted higher amounts of interferon (IFN)-γ than did those from control subjects, but paradoxically expressed lower levels of TIM3 and T-bet. Interleukin 12–mediated polarization of CSF clones induced substantially higher amounts of IFN-γ secretion but lower levels of TIM3 in MS clones relative to control clones, demonstrating that TIM3 expression is dysregulated in MS CSF clones. Reduced levels of TIM3 on MS CSF clones correlated with resistance to tolerance induced by costimulatory blockade. Finally, reduction of TIM3 on ex vivo CD4+ T cells using small interfering (si)RNA enhanced proliferation and IFN-γ secretion, directly demonstrating that TIM3 expression on human T cells regulates proliferation and IFN-γ secretion. Failure to up-regulate T cell expression of TIM3 in inflammatory sites may represent a novel, intrinsic defect that contributes to the pathogenesis of MS and other human autoimmune diseases.
Models of Man in Systems in Retrospect and Prospect

Abstract A number of historical and current theoretic and working or operational models are mentioned. It is held that none of these, by virtue of limitations to only a part of human behaviour, is completely valid for systems planning and design. Integrated models of man within systems and within environments are urgently required. The need is stressed to develop general systems models capable of describing and predicting human individual and collective behaviour of varied populations in a wide variety of systems and environments. Man-machine, sociotechnical, and social systems involving military, industrial, and civil applications must be considered. Our models should be reconcilable with models involving man in organizations and with ecological and economic models. Models must reflect the changing tenor of the times with regard to evolving social thought and practice. Criteria must therefore include quality of life and limits to growth as well as economic costs and performance effectiveness. Increasingl...
Implementation of peripheral blood CD34 analyses to initiate leukapheresis: marked reduction in resource utilization.

BACKGROUND: Analysis of the peripheral blood (PB) C34 value may determine the optimal time to initiate leukapheresis. STUDY DESIGN AND METHODS: After selecting a threshold PB CD34 value of five CD34 + cells per µL to initiate leukapheresis procedure, a prospective analysis of 50 consecutive patients was initiated to identify the optimal time to initiate leukapheresis and its impact on costs and resource utilization. Clinical decisions were made to commence or to postpone leukapheresis with this PB CD34 threshold number. Based on PB CD34 values for each patient, the number of leukapheresis procedures, postponed or canceled, the number of CD34+ cells per kg, and the total number of cells collected were identified. Costs of mobilization were obtained from the hospital cost accounting system. RESULTS: In 13 months, 50 patients with a hematologic disorder underwent mobilization. There were 34 cancellations or postponements of collections due to a low PB CD34 value in 13 patients. By use of our identified costs per initial collection, this resulted in a savings of $67,660. CONCLUSIONS: This prospective study defines how the implementation of the PB CD34 value results in costs savings. A low PB CD34 value canceled or postponed a significant number of leukapheresis procedures, resulting in a substantial cost savings. Use of the PB CD34 value should be the standard of care during mobilization and peripheral blood progenitor cell collection.
Type specimens in modern ornithology are necessary and irreplaceable

ABSTRACT Recent years have seen a series of new species descriptions in which no type specimen or fragmentary type specimen material was provided as documentation. These descriptions have been controversial, but the Code of Zoological Nomenclature makes clear that such nondiagnostic types are not acceptable specimen documentation. A more appropriate approach is documentation of the discovery, but without formal naming of the species, until suitable specimen documentation can be assembled.
Observation of Cement Paste Microstructure Evolution

During early hydration in fresh concrete, the cement paste hardens and bonds the aggregates together to make a solid concrete mass. During this process, along with chemical reactions, physical changes in the cement paste at the microlevel and the nanolevel also play major roles in the development of the properties of the concrete. An attempt was made to study the microstructure of cement paste and the evolution of its corresponding elastic modulus during setting. For this purpose, two different in situ testing methods, scanning electron microscopy (SEM) with a Quantomix capsuling system and a nondestructive one-sided ultrasonic technique, ultrasonic wave reflection method, were used. The features in the SEM images were quantified by the use of image analysis techniques, and quantitative analysis was used to examine the relationship between the microstructure of the cement paste and the corresponding dynamic shear modulus during the initial and final setting times. Cement particle growth, motions, and rota...
Radiation Balance and Equilibrium Models

Climate dynamics is a relatively new member of the family of geophysical sciences. Descriptive climatology goes back, of course, at least to the ancient Greeks, who realized the importance of the Sun’s mean zenith angle in determining the climate of a given latitude belt, as well as that of land-sea distribution in determining the regional, zonally asymmetric characteristics of climate. The general human perception of climate change is also preserved in numerous written records throughout history, starting with the floods described in the epic of Gilgamesh and in the Bible.
Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer

The multistage model of mouse skin carcinogenesis is a useful system in which biochemical events unique to initiation, promotion, or progression steps of carcinogenesis can be studied and related to cancer formation. 12-O-tetradecanoylphorbol-13-acetate (TPA), a component of croton oil, is a potent mouse skin tumor promoter (CRC Critical Reviews in Toxicology 2:419–443, 1974; The Journal of Investigative Dermatology Symposium Proceedings 1:147–150, 1996; Pharmacology and Therapeutics 54:63–128, 1992). A major breakthrough in understanding the mechanism of TPA tumor promotion has been the identification of protein kinase C (PKC), as its receptor. PKC, which is ubiquitous in eukaryotes, is a major intracellular receptor for TPA (Nature Reviews Cancer 7:281–294, 2007). PKC forms part of the signal transduction system involving the turnover of inositol phospholipids and is activated by DAG, which is produced as a consequence of this turnover (Nature Reviews Cancer 7:281–294, 2007). PKC represents a family of phospholipid-dependent serine/threonine kinases (Nature Reviews Cancer 7:281–294, 2007; Biochemical Journal 332:281–292, 1998; Chemical Reviews 101:2353–2364, 2001; Advances in Pharmacology 44:91–145, 1998). At least six PKC isoforms (α, δ, e, η, μ, ζ) are expressed in both human and mouse skin (International Journal of Biochemistry and Cell Biology 36:1141–1146, 2004). Evidence is presented in this chapter, using genetic approach in intact mouse skin in vivo, indicating that: (1) PKC isoforms exhibit functional specificity in skin cancer induction, (2) PKCe mediates the development of skin cancer and (3) PKCe signal transduction pathway to development of skin cancer involves Stat3 interaction and expression of proinflammatory cytokine TNFα.
Teaching by Example: Best Practices for Education in the Operating Room and the Lecture Hall

As medical education evolves, the next generation of medical educators must adapt to new paradigms and adopt new strategies for effective clinical and didactic education to remain current and effective teachers. The most successful anesthesia educators in the operating room environment are able to balance the needs of patient care and the demands of an ever-increasing clinical schedule and still make time for teaching at the bedside. It is not enough, however, just to make time for education. Today’s clinician educator must also create an effective learning environment, elicit feedback, encourage students to teach others, and, most importantly, teach by example.
Mass Egg Production by the Coccinellid Hippodamia Convergens Guer

Methods for obtaining egg production by the convergent ladybeetle through the use of frozen aphids have been reported by the writer in another paper (1938). By using frozen aphids, satisfactory egg production can be maintained at any time of the year.
The shifting etiologies of lobar hemorrhage.

Better treatment of hypertension is changing the type of intracranial hemorrhages physicians most often see.
Epicardial surgical ligation of the left atrial appendage is safe, reproducible, and effective by transesophageal echocardiographic follow-up.

ObjectiveThe left atrial appendage (LAA) is the source of 90% of thrombi in patients with atrial fibrillation. Our double LAA ligation (LLAA) technique was shown to be 96% successful in a small stu...
Semantic Compositionality: Still the Only Game in Town

It is standardly assumed that theories of meaning for natural languages will be compositional. That is, a theory of meaning for a language, E, will consist of a characterization of the semantic features of some set of primitive components of E, along with rules for recursively determining the semantic features of the more complex expressions of E. The main line of support for the compositionality of a theory of meaning, and more importantly for the existence of compositional theories of meaning, arises from the following considerations. First, speakers can comprehend an infinite or at least an indefinitely large number of sentences. In order to explain how we manage to understand indefinitely many sentences we must assume that we have a compositional understanding. That is, we are able to understand indefinitely many sentences because our understanding of sentences is a matter of our understanding parts of sentences. Second, it is generally accepted that a theory of meaning should characterize the explicit or implicit knowledge that is applied in understanding. So a semantic theory will explain the meanings of sentences by explaining the meanings of parts of sentences. That is, if we are going to explain (semantic) language understanding, we will need a compositional theory of meaning. As part of an ambitious attempt to persuade us that a theory of meaning is not feasible, Stephen Schiffer [2] has challenged this 'productivity' argument for a compositional theory of meaning by presenting a hypothetical case of a language understander whose means of understanding languages supposedly fails to support compositionality. He has also provided an argument that is supposed to show that it is possible for us to explain a (hypothetical) mentalese (i.e. language of thought) without the need for a compositional theory of mentalese. As I will show, though, his cases fail to address the central concern of the productivity argument, namely the explanation of infinite understanding through finite means, and are therefore unsuccessful attacks on our commitment to a compositional theory of meaning.
Abstract POSTER-THER-1422: Development of proteomic biomarkers for the apoptosis pathway in ovarian cancer cell lines and determination of the appropriate sequence of the SMAC-mimetic birinapant (TL32711) and docetaxel for optimal therapeutic effect

Background: The SMAC-mimetic birinapant (TL32711) induces apoptosis of ovarian cancer (OC) cell lines by eliminating the inhibitors of apoptosis (IAPs) and attenuating NFkB signaling. The increase in mitochondrial membrane permeability (MOMP) induced by docetaxel releases cytochrome c, unleashing the caspase cascade, which culminates in apoptosis. In addition, caspase-8 cleavage results in activation of the BH3-only protein BH3-interacting domain death agonist (BID), the product of which (truncated BID; tBID) is required for death receptor-induced apoptosis via BID activation and MOMP. Thus, caspase-8 is at the intersection between the extrinsic and intrinsic apoptosis pathways. We hypothesized that the combination of birinapant and docetaxel would be synergistic augmenting the apoptotic response in OC. Our aim was to determine the most appropriate sequence for optimal therapeutic effect in a cell line model and develop potential proteomic biomarkers. Methods: Toxicity of the SMAC-mimetic birinapant and docetaxel was assessed in a panel of OC cell lines using XTT assay with specific attention to the order and timing of drug administration. The target protein changes were assessed using Western blot and Simple Western. Similar protein changes are being assessed in mouse model. Cytokine analysis was performed on the secretome of cells treated with drug. Results: There was variable sensitivity to single-agent exposure to the small molecule SMAC mimetic in OC cell lines. Increased cell death was seen upon administration of both docetaxel and birinapant, with enhanced toxicity when birinapant was administered prior to docetaxel. Degradation of cIAP1, the main pharmacodynamic outcome of brianapant, was seen after one hour of birinapant exposure, and was maintained up to 12 hours. Interestingly, cIAP2 levels increased from 3 hours to 24 hours. Cleavage of caspase-3 began at 3 hours and was maximal at 24 hours. PARP cleavage occurred 24 hours after treatment. Docetaxel induced cleavage of BID. Enhanced caspase-3 and caspase-8 cleavage were seen when both birinapant and doctaxel were administered. Similar protein changes are being examined in ongoing mouse experiment and will be reported at the meeting. Conclusions: The combination of birinapant and docetaxel results in enhanced cell death in an OC cell line model with evidence of target protein engagement. Citation Format: Anne M. Noonan, Lidia Hernandez, Michelle Herrmann, Jinqui Chen, Christina M. Annunziata. Development of proteomic biomarkers for the apoptosis pathway in ovarian cancer cell lines and determination of the appropriate sequence of the SMAC-mimetic birinapant (TL32711) and docetaxel for optimal therapeutic effect [abstract]. In: Proceedings of the 10th Biennial Ovarian Cancer Research Symposium; Sep 8-9, 2014; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(16 Suppl):Abstract nr POSTER-THER-1422.
Comparison of all optical forwarding packet architectures

In this paper two all optical packet forwarding architectures based on non linear effect in semiconductor optical amplifier in Mach-Zehnder configuration SOA-MZI are studied. The first architecture consist in combing flip flop functionality with the AND logic functionality in the same unit. Error free operation at 40 Gbps for two cascaded nodes is achieved. In the second architecture two separated units namely the flip flop and the AND logic gate are used. 100 Gbps bit rate is reached. At 40 Gbps error free operation is achieved for three cascaded nodes.
An Approach of Cross-Security Zone Data Transmission for Secondary System and Its Application in Load Forecasting

The problem of cross-security zone data transmission of secondary system existing in Lianyungang power network is introduced.To solve this problem,a cross-security zone data transmission and sharing system is proposed.The architecture of current security protection system for secondary system and the features of data transmission via physical isolation devices are analyzed and how to design and encapsulate various communication protocols to carry out data exchange and transmission are researched.An actual example of applying cross-security zone data transmission and sharing in the construction of load forecasting system for Lianyungang power network is given.
Disaster Preparedness in Home-based Primary Care: Policy and Training

Introduction Veterans served by Veterans Health Administration (VHA) home-based primary care (HBPC) are an especially vulnerable population due to high rates of physical, functional, and psychological limitations. Home-bound patients tend to be an older population dealing with normal changes that accompany old age, but may not adequately be prepared for the increased risk that often occurs during disasters. Home health programs are in an advantageous position to address patient preparedness as they may be one of the few outside resources that reach community-dwelling adults. Problem This study further explores issues previously identified from an exploratory study of a single VHA HBPC program regarding disaster preparedness for HBPC patients, including ways in which policy and procedures support the routine assessment of disaster preparedness for patients, including patient education activities. Methods This project involved semi-structured interviews with 31 practitioners and leadership at five VHA HBPC programs; three urban and two rural. Transcripts of the interviews were analyzed using content analysis techniques. Results Practitioners reported a need for further training regarding how to assess properly patient disaster preparedness and patient willingness to prepare. Four themes emerged, validating themes identified in a prior exploratory project and identifying additional issues regarding patient disaster preparedness: (1) individual HBPC programs generally are tasked with developing their disaster preparedness policies; (2) practitioners receive limited training about HBPC program preparedness; (3) practitioners receive limited training about how to prepare their patients for a disaster; and (4) the role of HBPC programs is focused on fostering patient self-sufficiency rather than presenting practitioners as first responders. There was significant variability across the five sites in terms of which staff have responsibility for preparedness policies and training. Conclusion Variability across and within sites regarding how patient needs are addressed by preparedness policies, and in terms of preparedness training for HBPC providers, could place patients at heightened risk of morbidity or mortality following a disaster. Despite the diversity and uniqueness of HBPC programs and the communities they serve, there are basic aspects of preparedness that should be addressed by these programs. The incorporation of resources in assessment and preparedness activities, accompanied by increased communication among directors of HBPC programs across the country, may improve HBPC programs’ abilities to assist their patients and their caregivers in preparing for a disaster. Claver ML , Wyte-Lake T , Dobalian A . Disaster Preparedness in Home-based Primary Care: Policy and Training . Prehosp Disaster Med . 2015 ; 30 ( 4 ): 1 7.
End stage polycystic kidney disease: management by renal transplantation and selective use of preliminary nephrectomy.

AbstractThe results have been reviewed of 35 renal transplants performed on 31 patients with end stage polycystic renal disease. Patient survival is 81 per cent and 71 per cent of the patients have functioning grafts at an average followup of 3.1 years. The need for pre-transplant nephrectomy was evaluated early in the series and since then the operation has been practiced selectively. Twenty-two patients have received transplants with both polycystic kidneys in situ, while 2 patients have undergone transplantation after unilateral nephrectomy. In the absence of a history of renal infection or significant hematuria it has proved safe and desirable to leave the polycystic kidneys in situ. During the post-transplant period in such cases there has been no difficulty attributed to the in situ polycystic kidneys after more than 450 patient months of immunosuppressive therapy. The size of the polycystic kidneys has not been an indication for nephrectomy in our series and no significant technical difficulties ha...
Analyzing gaze synchrony in cinema: a pilot study

Recent advances in personalized displays now allow for the delivery of high-fidelity content only to the most sensitive regions of the visual field, a process referred to as foveation [Guenter et al. 2012]. Because foveated systems require accurate knowledge of gaze location, attentional synchrony is particularly relevant: this is observed when multiple viewers attend to the same image region concurrently.
More research, yes! But what kind?

Fescription de l'evolution de la recherche en optometrie aux Etats-Unis: points forts a developper, financement, repartition par Etat relations avec l'enseignement et comparaison avec les autres specialites biomedicales
The Effect of Actual and Perceived Time Availability on Voluntarism

This study investigates the relationship between actual time availability and perceived time availability to hours volunteered on an individual level of analysis. A direct relationship was hypothesized for both variables, given that time is the currency one pays for the rewards of volunteering. Neither hypothesis was supported, with actual time unrelated and perceived time negatively related to voluntarism.
Schrumpfende Ressourcen und wachsende Kosten: Ökonomie, Medizin und Gemeinschaft

In den letzten Jahrzehnten sind die Kosten fur das Gesundheitswesen in der ganzen Welt stark angewachsen und drohen in manchen Landern bald fast unfinanzierbar zu werden. Im 19. und besonders in diesem Jahrhundert haben sich die diagnostischen und therapeutischen Methoden vervielfacht, die zwar viele Vorteile, aber auch sehr hohe Kosten mit sich gebracht haben. Durch tagliche Berichte der Medien uber die „Wunder der Medizin“ ubersteigen die Erwartungen der Patienten die tatsachlichen Moglichkeiten des Gesundheitswesens: fast jeder will fur sich selbst oder fur seine Familie alles nur Mogliche in Anspruch nehmen, ist aber nicht bereit, durch Steuern oder Versicherungsbeitrage dasselbe fur seinen Nachbarn zu ermoglichen.
Density fluctuations in baryon-rich quark matter

At finite baryon chemical potential, the density of a quark matter develops large fluctuations when it undergoes a first-order phase transition. Based on the transport equation derived from the Nambu–Jona-Lasinio (NJL) model, we have studied the density fluctuations in a baryon-rich quark matter that is confined in a finite volume. Allowing the expansion of the quark matter using initial conditions from either a blast wave model or a multiphase transport (AMPT) model, we have further studied the survivability of the density fluctuations as the density and temperature of the quark matter decrease. Possible experimental signatures of the density fluctuations are suggested.
Family health history and future nursing practice: Implications for undergraduate nursing students.

• A complete and accurate family health history is an integral part of providing comprehensive care.
Theta- and delta-band EEG network dynamics during a novelty oddball task

While the P3 component during target detection and novelty processing has been widely studied, less is known about its underlying network dynamics. A recent cognitive model suggests that frontal-parietal and frontal-temporal interregional connectivity are related to attention/action selection and target-related memory updating during the P3, respectively, but empirical work testing this model is lacking. Other work suggests the importance of theta- and delta-band connectivity between the medial frontal cortex and distributed cortical regions during attention, stimulus detection, and response selection processes, and similar dynamics may underlie P3-related network connectivity. The present study evaluated the functional connectivity elicited during a visual task, which combined oddball target and novelty stimuli, in a sample of 231 same-sex twins. It was hypothesized that both target and novel conditions would involve theta frontoparietal connectivity and medial frontal theta power, but that target stimuli would elicit the strongest frontotemporal connectivity. EEG time-frequency analysis revealed greater theta-band frontoparietal connectivity and medial frontal power during both target and novel conditions compared to standards, which may index conflict/uncertainty resolution processes. Theta-band frontotemporal connectivity was maximal during the target condition, potentially reflecting context updating or stimulus-response activation. Delta-band frontocentral-parietal connectivity was also strongest following targets, which may be sensitive to response-related demands. These results suggest the existence of functional networks related to P3 that are differentially engaged by target oddballs and novel distractors. Compared to simple P3 amplitude, network measures may provide a more nuanced view of the neural dynamics during target detection/novelty processing in normative and pathological populations.
Methamphetamine-induced choreoathetosis: A case report

We describe the case of a 23-year-old male with a past psychiatric history of Obsessive Compulsive disorder, Generalized Anxiety Disorder, Cannabis Use Disorder, and a reported history of Bipolar II Disorder and ADHD, and no past medical history, who presented to the hospital for a psychiatric evaluation of erractic behavior. Per his family's report, the patient has not been attending to his activities of daily living and has had poor sleep and significant weight loss for the past month. In the days preceding his presentation, he has experienced worsening irritability and rapid speech, and has been responding to internal stimuli and displaying odd repetitive movements of his extremities. On interview, the patient reported non-compliance to his prescribed Lithium and Paroxetine for the past three months. He also noted recently smoking methamphtamine on a daily basis for the past month and intermittently abusing cannabis, benzodiazepines and cocaine. His urine drug screen was positive for cannabinoids and amphetamines and the rest of his medical workup was within normal limits. On physical exam, he exhibited involuntary writhing and twisting movements of his extremities. An atypical antipschotic was prescribed, after which his choreoathetotic movements resolved within 24 hours. The purpose of this poster is to highlight the possibility of developing chorea as a result of methamphetamine use, given the rarity of such cases, and to discuss whether the resolution of his neurological symptoms were a result of antipsychotic administration or were simply due to the natural course of methamphetamine discontinuation during hospitalization.
Config: A Mechanism for Installing and Tracking System Configurations

One problem that faces system administrators is how to install and maintain local configuration information on a large number of machines. Some previous approaches such as cloning [2] help, but they only provide a baseline, not ongoing configuration control. Other mechanisms such as Typecast [7], Hobgoblin [5], Scrape [3] or Mkserv [6] assist in the configuration process, and provide some support for ongoing maintenance. However supporting multiple system configurations is still troublesome. Also it can be very difficult to delegate system administration tasks. Insufficient logging of file changes can create a nightmare when attempting to find the cause of a problem. The method we present uses rdist and integrates it with make(1) and the CVS version control system to provide the ability to delegate and log changes. End node users can make changes to their workstations, however all changes are logged, so that it is possible to see what has changed on a given machine when problems occur. When making changes that affect a large number of machines (e.g., amd automount maps, rc files) previous versions of the file are available in the CVS tree and can be retrieved and distributed in case of unforeseen problems.
A mobile robot for locomotion through a 3D periodic lattice environment

This paper describes a novel class of robots specifically adapted to climb periodic lattices, which we call “Relative Robots”. These robots use the regularity of the structure to simplify the path planning, align with minimal feedback, and reduce the number of degrees of freedom (DOF) required to locomote. They can perform vital inspection and repair tasks within the structure that larger truss construction robots could not perform without modifying the structure. We detail a specific type of relative robot designed to traverse a cuboctahedral (CubOct) cellular solids lattice, show how the symmetries of the lattice simplify the design, and test these design methodologies with a CubOct relative robot that traverses a 76.2 mm (3 in.) pitch lattice, MOJO (Multi-Objective JOurneying robot). We perform three locomotion tasks with MOJO: vertical climbing, horizontal climbing, and turning, and find that, due to changes in the orientation of the robot relative to the gravity vector, the success rate of vertical and horizontal climbing is significantly different.
Long-Term Visual Outcomes, Complications, and Retention of the Boston Type I Keratoprosthesis.

Purpose To report the long-term outcomes of the Boston type I keratoprosthesis (KPro). Methods Data were collected regarding preoperative characteristics, surgical procedure(s) performed, and postoperative outcomes of patients who underwent KPro implantation from May 1, 2004, to May 1, 2011, and were followed for 5 years after surgery. Results Seventy-four KPro procedures were performed in 58 eyes (55 patients), with more than 1 KPro implanted in 10 eyes. The mean follow-up duration was 82.8 ± 20.5 months (range 57-145 months), and the most common indication for keratoprosthesis implantation was corneal transplant failure (50%). Preoperative corrected distance visual acuity (CDVA) was ≥20/200 in 5%; between 1 and 8 years after surgery, the percentage of eyes with CDVA ≥20/200 varied between 57% (4 years) and 82% (8 years). Nineteen (25.7%) KPros implanted were removed (retention failure rate 0.047/eye-year), although a KPro was retained at final follow-up in 55 eyes (94.8%). The most common postoperative complication was retroprosthetic membrane formation in 51.7% of eyes. The incidence of each postoperative complication decreased significantly over the first 10 years after surgery. Conclusions The KPro provides significant visual improvement in most eyes, with more than 50% regaining and maintaining 20/200 CDVA each year through 8 years after surgery. The incidence of each postoperative complication decreases significantly over the first 10 years after surgery. Although almost one-quarter of implanted keratoprostheses were removed, over 90% of eyes reaching 5 years of follow-up retain a keratoprosthesis at final follow-up.
“Women Friendly” Spending? Welfare Spending and Women's Participation in the Economy and Politics

What effect do social welfare policies have on women's active involvement in the economy and politics? Though there is much policy and scholarly debate on a wide spectrum of socioeconomic and political outcomes of welfare spending, little research has explored the possible impact that social welfare policies have on one of the supposed major beneficiaries of such policies—women. Combining data on welfare spending in three areas—social security, health, and education—with data on women's labor force participation and share of seats in national legislatures, this article examines the extent to which welfare spending might affect women's economic and political status. The results from a panel of 97 countries for the years spanning 1990 to 2010 indicate that the government's fiscal commitment to social policies is positively related to female participation in the total labor force and national politics. The findings are robust to different model specifications, sample selection, and the use of instrumental variables. One major policy implication of the findings is that the government's fiscal commitment to key social welfare areas are likely to contribute to women's economic and political empowerment, which might in turn help address gender imbalances in the economy and political sphere.
A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis

Secukinumab is an interleukin-17 inhibitor used for the treatment of ankylosing spondylitis (AS), psoriasis, and psoriatic arthritis. The risk of exacerbating underlying inflammatory bowel disease (IBD) in patients being treated with secukinumab for other conditions is controversial. We document a patient with AS and previously undiagnosed IBD, found to be in a severe ulcerative colitis flare shortly after receiving the loading dose of secukinumab. There are no guidelines regarding biologic salvage therapy for IBD in the setting of active treatment with another biologic agent. After waiting one half-life of secukinumab, our patient had an excellent response to initiation of infliximab.
Establishing EDI for a Clinical Trial of a Treatment for Chikungunya

Ellagic acid (EA) is a polyphenolic compound with antiviral activity against chikungunya, a rapidly spreading new tropical disease transmitted to humans by mosquitoes and now affecting millions worldwide. The most common symptoms of chikungunya virus infection are fever and joint pain. Other manifestations of infection can include encephalitis and an arthritic joint swelling with pain that may persist for months or years after the initial infection. The disease has recently spread to the U.S.A., with locally-transmitted cases of chikungunya virus reported in Florida. There is no approved vaccine to prevent or medicine to treat chikungunya virus infections. In this study, the Estimated Daily Intake (EDI) of EA from the food supply established using the National Health and Nutrition Examination Survey (NHANES) is used to set a maximum dose of an EA formulation for a high priority clinical trial.
Characterizing growth rates and growth rate dispersion of secondary nuclei as a function of supersaturation

The purpose of this work was to characterize sodium nitrate secondary nuclei growth rate dispersion as a function of the supersaturation conditions present during nucieation and growth. Two methods producing two sets of data were recorded. The first set included examining the response of the growth rate distributions at four different supersaturations. The second set of data examined the response surface of growth rate dispersion (GRD) parameters where the supersaturation at nucieation and during growth were both altered. GRD causes deviations from the theoretical crystal size distribution predicted by the population balance. The most visible effect of GRD is the presence of more crystals in the small size range than is predicted by theory for mixed-suspension mixed-product removal continuous crystallizers. GRD is a key factor in determining how various crystallization systems operate. The growth rates of nuclei determine the number of crystals that will grow large enough to populate the upper sizes of the crystal size distribution and contribute to the final product mass. 1 Please Contact Christopher Jones in Correspondence for this Paper
Right data for right patient-a precisionFDA NCI-CPTAC Multi-omics Mislabeling Challenge.

To address a critical roadblock that can occur in translational and clinical research, the National Cancer Institute and the Food and Drug Administration, in coordination with the DREAM Challenges, are launching the first computational challenge using multi-omics datasets to detect and correct specimen mislabeling.
A Simulation-Based Coupling Path Characterization to Facilitate Desense Design and Debugging

Coupling path characterization is the most critical part of the simulation-based method to investigate desense issues. This paper introduces the workflow to model and validate the coupling path. The workflow is then embodied in a practical case where the GPS system of a phone is severely desensitized by the camera flex. The coupling path between the camera flex and the GPS antenna is successfully characterized and validated by measurement. The obtained coupling path model is further utilized to study factors that potentially affect the noise coupling from the camera flex to the GPS system. Knowledge of these factors facilitates desense design and debugging. Design guidelines are proposed based on the coupling path model.
Scientifically based research in a post-truth era

In this article, I explore the tension between the current political context in which science needs defending against anti-intellectualism and outright assaults on evidence as a means of decision-making on the one hand and the overzealous scientism that can result from backlash against a perceived lack of rigor in various forms of inquiry. To do so, I return to the emergence of the discourse of scientifically based research (SBR) in education and the debates surrounding it (2002-2013), which have implications for how and why educational researchers would advocate for science and what that advocacy might do. Specifically, I argue that we must have a science that does not allow alternative facts and politically expedient truth claims while still allowing science to be flexible, responsive, and theoretically informed. I conclude by advocating for theoretically informed activism and non-innocent science.
Incorporating Multicultural Couple and Family Therapy Into Incarcerated Settings

Incarceration rates have increased significantly since the 1990s, with more than two million adults in federal, state, and local facilities. More than half of the offenders report a history of mental health issues, highlighting the importance of offenders having access to effective therapeutic approaches, including individual, couples, and family counseling. Traditionally, the focus of mental health services has been individual treatment; however, family members are also significantly impacted by the offender's absence during incarceration. Incorporating family members into treatment can serve to improve relationships, leading to better outcomes at reentry and reductions in recidivism rates. Given the preponderance of persons of color in the incarcerated population, diversity issues in counseling must also be addressed. The purpose of the underlined article is to explore the implications of incorporating multicultural family therapy into incarcerated settings.
A 0.4–1.0 GHz, 47 MHop/s Frequency-Hopped TXR Front End With 20 dB In-Band Blocker Rejection

In this paper, we present a prototype ultra-fast hopping spread spectrum transceiver front-end that realizes 20 dB of processing gain in the RF before any amplification occurs along the receiver chain. This means that a narrow-band in-band interferer is rejected by 20 dB before the low noise amplifier (LNA). The correlation function at RF is made possible by using a passive mixer-first receiver architecture that is driven by an ultra-fast hopped local oscillator (LO) signal. The 47 MHop/s LO is generated using an all-digital oscillator circuit that is followed by a memoryless digital-to-analog converter (DAC). The prototype chip fabricated in a Taiwan Semiconductor Manufacturing Company (TSMC) 65 nm RF CMOS process occupies 3.1 mm2 of active area. The receiver and the transmitter each consume ≈25 mW from a 1 V power supply.
Genomic and physiological analyses reveal that extremely thermophilic Caldicellulosiruptor changbaiensis deploys uncommon cellulose attachment mechanisms

The genus Caldicellulosiruptor is comprised of extremely thermophilic, heterotrophic anaerobes that degrade plant biomass using modular, multifunctional enzymes. Prior pangenome analyses determined that this genus is genetically diverse, with the current pangenome remaining open, meaning that new genes are expected with each additional genome sequence added. Given the high biodiversity observed among the genus Caldicellulosiruptor, we have sequenced and added a 14th species, Caldicellulosiruptor changbaiensis, to the pangenome. The pangenome now includes 3791 ortholog clusters, 120 of which are unique to C. changbaiensis and may be involved in plant biomass degradation. Comparisons between C. changbaiensis and Caldicellulosiruptor bescii on the basis of growth kinetics, cellulose solubilization and cell attachment to polysaccharides highlighted physiological differences between the two species which are supported by their respective gene inventories. Most significantly, these comparisons indicated that C. changbaiensis possesses uncommon cellulose attachment mechanisms not observed among the other strongly cellulolytic members of the genus Caldicellulosiruptor.