cssi/SciSciGPT-SciSciNet huggingface dataset:
Protein-Protein Docking: From Interaction to Interactome

The protein-protein docking problem is one of the focal points of activity in computational biophysics and structural biology. The three-dimensional structure of a protein-protein complex, generally, is more difficult to determine experimentally than the structure of an individual protein. Adequate computational techniques to model protein interactions are important because of the growing number of known protein structures, particularly in the context of structural genomics. Docking offers tools for fundamental studies of protein interactions and provides a structural basis for drug design. Protein-protein docking is the prediction of the structure of the complex, given the structures of the individual proteins. In the heart of the docking methodology is the notion of steric and physicochemical complementarity at the protein-protein interface. Originally, mostly high-resolution, experimentally determined (primarily by x-ray crystallography) protein structures were considered for docking. However, more recently, the focus has been shifting toward lower-resolution modeled structures. Docking approaches have to deal with the conformational changes between unbound and bound structures, as well as the inaccuracies of the interacting modeled structures, often in a high-throughput mode needed for modeling of large networks of protein interactions. The growing number of docking developers is engaged in the community-wide assessments of predictive methodologies. The development of more powerful and adequate docking approaches is facilitated by rapidly expanding information and data resources, growing computational capabilities, and a deeper understanding of the fundamental principles of protein interactions.
Myosin 3A transgene expression produces abnormal actin filament bundles in transgenic Xenopus laevis rod photoreceptors

Myo3A, a class III myosin, localizes to the distal (plus) ends of inner segment actin filament bundles that form the core of microvillus-like calycal processes encircling the base of the photoreceptor outer segment. To investigate Myo3A localization and function, we expressed green fluorescent protein-tagged bass Myo3A and related constructs in transgenic Xenopus rods using a modified opsin promoter. Tagged intact Myo3A localized to rod calycal processes, as previously reported for native bass Myo3A. Transgenic rods developed abnormally large calycal processes and subsequently degenerated. Modified Myo3A expression constructs demonstrated that calycal process localization required an active motor domain and the tail domain. Expressed tail domain alone localized to actin bundles along the entire inner segment length, rather than to the distal end. This tail domain localization required the conserved C-terminal domain (3THDII) previously shown to possess an actin-binding motif. Our findings suggest that Myo3A plays a role in the morphogenesis and maintenance of calycal processes of vertebrate photoreceptors.
History of Neurosurgery at Evanston Hospital and NorthShore University HealthSystems

Ivan Ciric, MD, FACS ull-time neurosurgery service at Evanston Hospital was established first y Dr. Joseph Tarkington in 1951. Before that, neurosurgical services at vanston Hospital were provided by neurosurgeons from Passavant emorial Hospital on an itinerary basis, mostly in terms of covering mergencies. Dr. Tarkington, who received his neurosurgical training at he Montreal Neurological Institute under Dr. Wilder Penfield and at assavant Memorial Hospital under Dr. Loyal Davis, practiced Neurourgery alone for 16 years. Dr. Tarkington was a general neurosurgeon of reat skills who, commensurate with his training under leading neurosureons of his time, was equally facile with cranial as well as with spinal urgery. His special interest was in cerebral arteriovenous malformations, challenging field at that time. In 1967, he was joined in practice by Dr. van Ciric. Dr. Ciric trained with Dr. Wilhelm Toennis in Cologne, ermany, followed by neurosurgery residency at Wesley Memorial ospital, 1 of the 2 teaching hospitals of Northwestern University (NU) edical School, under Dr. Paul Bucy and fellowship in pituitary surgery nder Dr. Jules Hardy at University of Montreal. Dr. Ciric introduced the se of the operating microscope and microsurgical techniques in cranial s well as in spinal surgery and performed the first transsphenoidal ituitary surgery, using the operating microscope, in the United States in ovember of 1967. In 2000, Dr. Ciric established the Evanston Hospital kull Base Laboratory, where scores of neurosurgery and other specialties rainees were able to hone their microsurgical skills in the laboratory etting. The same year, Dr. Jin-Chen Zhao was appointed full-time irector of that laboratory. Dr. Ciric has operated on over 2000 pituitary umors and over 300 acoustic neuromas. Upon Dr. Tarkington’s retireent, Dr. Ciric led the Division of Neurosurgery from 1984 to 2000 and gain on an interim basis from 2008 to 2010.
Fast and Efficient Simulation of Diffuse Light using Wiener Chaos Expansion and its Applications for Design of Photonic Crystal Spectrometers

We present an efficient model for simulation of spatially incoherent sources based on Wiener chaos expansion (WCE) method with two orders of magnitude improvement over the brute-force techniques. While the technique is general, we apply it to the analysis and design of photonic crystal spectrometers for diffuse source spectroscopy.
Behavioral responses of Escherichia coli to changes in temperature caused by electric shock.

The behavioral response of Escherichia coli to electric shock in 10(-2) M potassium phosphate plus 10(-4) M potassium EDTA was studied. When presented with a 150-V/cm electric shock that lasted 250 ms, the bacteria at first exclusively ran, then exclusively tumbled, and finally returned to their original running and tumbling. This response is due to increased temperature caused by the electric shock, i.e., to thermotaxis, and it is mediated by the chemotaxis machinery. A more severe electric shock, 150 V/cm for 550 ms, caused cells to tumble immediately, and then they went back to their original running and tumbling. The mechanism of that response is unknown since, unlike known thermotaxis, it does not require the chemotaxis machinery.
REPRODUCTIVE SUCCESS AND SURVIVAL IN RELATION TO EXPERIENCE DURING THE FIRST TWO YEARS IN CANADA GEESE

Abstract We studied the relationship between family associations of immature Canada Geese (Branta canadensis) and their reproductive success as 2-year-olds and survival to three years. A higher proportion of immature Canada Geese associated with family members survived to breeding age and were more successful in reproducing in their first potential year of sexual maturity (age 2) than were geese that were not in family associations. These results illustrate the benefits of prolonged parental care outweighing costs to parents and the probable influence of family association on future successful breeding. Many reproductive failures of vertebrates with complex social organization may be related to experience during maturation.
The Zoot Suit: Its History and Influence

(2004). The Zoot Suit: Its History and Influence. Fashion Theory: Vol. 8, No. 2, pp. 225-236.
Perceived Skills, Self-Efficacy, and Attitudes Toward Technology: A Pilot Study of BSW Students

The Council on Social Work Education has called for the increased use of relevant technology; however, limited research is available on social work students’ perceived skills, self- efficacy, and attitudes toward technology. This study examined 215 BSW students’ perceived confidence, skills, attitudes, and self- efficacy regarding technology use before and after taking a social work and technology course. Significant differences were found in all factors except attitude. Age was negatively correlated with perceived skills and self- efficacy. Qualitative data on how students felt about technology in their future roles as social workers identified six themes: better service provision, changes in communications, improved access and productivity, client involvement, concerns with confidentiality, and role of technology. Recommendations for future research and implications for social work education and practice are discussed.
Abstract 146: Administration of Interleukin-19 Halts Progression of Pre-formed Plaque, Polarizes Macrophage, and Increases Macrophage Lipid Uptake.

Increased uptake of oxLDL by macrophage is proposed to be an atheroprotective mechanism to reduce plaque formation. It has been proposed that macrophage phenotype may be causative or at least associated with plaque severity. Several macrophage phenotypes have been classified, and M2 macrophage are considered to be anti-inflammatory and reparative. Interleukin-19 is a purported anti-inflammatory, Th2 interleukin, and we previously found that addition of rIL-19 could significantly reduce atherosclerosis in susceptible mice. The purpose of this study was to test the hypothesis that administration of exogenous IL-19 could attenuate progression of pre-formed atherosclerotic plaque, and to identify potential molecular mechanisms. LDLR-/- mice were fed high-fat diet for 12 weeks, then administered rIL-19 (10ng/g/day) or PBS for an additional 8 weeks while still consuming HFD. En face analysis demonstrated that IL-19 could halt, but not reverse existing plaque. M2 macrophage marker expression was significantly increased in aorta and spleen from IL-19 treated mice, in IL-19-treated bone marrow derived macrophage (BMDM) and primary human macrophage. IL-19 significantly decreased expression of inflammatory cytokines TNFa, IL-12p40, MCP-1 and IL-1b mRNA in BMDM. Addition of IL-19 to BMDM significantly increased oxLDL uptake as well as expression of lipid uptake receptors CD36, SRA-1, and SRB-1 in primary human macrophage. IL-19 increased expression and activation of PPARg. Knock down of PPARg significantly decreased IL-19 mediated expression of both lipid uptake receptors and uptake of oxLDL. Collectively, these data show that IL-19 can halt progression of established plaque by at least two mechanisms; M2 macrophage polarization, and increasing expression of lipid scavenger receptors and cholesterol uptake in a PPARg-dependent mechanism, suggesting therapeutic potential for this interleukin.
Large-Scale Graph Classification Based on Evolutionary Computation with MapReduce

Discriminative subgraph mining from a large collection of graph objects is a crucial problem for graph classification. Several main memory-based approaches have been proposed to mine discriminative subgraphs, but they always lack scalability and are not suitable for large-scale graph databases. Based on the MapReduce model, we propose an efficient method, MRGAGC, to process discriminative subgraph mining. MRGAGC employs the iterative MapReduce framework to mine discriminative subgraphs. Each map step applies the evolutionary computation and three evolutionary strategies to generate a set of locally optimal discriminative subgraphs, and the reduce step aggregates all the discriminative subgraphs and outputs the result. The iteration loop terminates until the stopping condition threshold is met. In the end, we employ subgraph coverage rules to build graph classifiers using the discriminative subgraphs mined by MRGAGC. Extensive experimental results on both real and synthetic datasets show that MRGAGC obviously outperforms the other approaches in terms of both classification accuracy and runtime efficiency.
The medical extension agent.

Jesse W. Tapp, MD, Lexington, Ky T HE UNIVERSITY of Kentucky College of Medicine was established in 1956, with the intention that "the community must be utilized as a laboratory in which the medical school studies certain problems."! The community in question, then and still, is the entire state and all of its people needing health care. Therefore, the university established, in 1960, the only department of community medicine in a US medical school at that time to investigate the health problems of communities and populations and to seek to develop solutions to these problems.2 With this objective for the discipline of community medicine, the Kentucky department has sought to help academic medicine form a more meaningful partnership with the private and public sectors of the medical profession. The entire state has been extensively used for teaching undergraduate medical students and residents in community medicine through community health and epidemiologic studies in over two thirds of the state's counties. The methods of this teaching have been described3-5 and will only be touched on here. The problems encountered in linking academic, private, and public medicine have not been unexpected. To begin with, Kentucky spans 400 miles from the Mississippi River to the Appalachians, so major transportation obstacles have to be overcome to accomplish this task. Town and gown problems which have been widely discussed,6 are as prevalent in Kentucky as anywhere. The
A Rational Basis for a Priori Character Weighting

Previously presented arguments for and against character weighting in systematic analyses are briefly reviewed and the bases for different weighting methods summarized. A priori and a posteriori methods are defined. I conclude that a priori weighting is the only noncircular approach for weighting of characters in the construction or recognition of groups of taxa, but that no objective method of a priori weighting has been proposed to date. A hy- pothetico-deductive methodology for character analysis completely prior to and independent of cladistic analysis (or phylogeny reconstruction) is briefly summarized. Identifications and characters are shown to be hypotheses testable prior to the construction of a cladogram. In that context, rather than attempting to weight on intrinsic properties of characters as suggested up to now, weighting on the basis of the relative degree of corroboration of the character in the character analysis provides a rational basis for character weighting if character conflicts occur in the cladistic analysis. (Character analysis; cladistic analysis; character weighting; phylogenetic analysis.) Two questions have traditionally been addressed in the evaluation of character weighting methods in systematic analysis. One is: can we judge the importance or reliability of a character's contribution to our estimates of relationships among taxa and, if so, how can we do so? The second question is: even if we can judge a char-
A linearized discrete radius pulley model for finite element analysis

The linearization of a pulley with a finite radius disk is presented for the solution of suspension problems involving pulleys and multiple cable links. The stiffness equations are derived for the pulley sheeve free to rotate about its axle and restricted from rotating about its axle. An example problem is presented containing four pulleys and six cable links. The example problem results are compared with experimental results. The size of the finite element pulley is varied to show its effect on the frequencies of the suspension.
Conclusion: Towards the Next Edition

We began this study by suggesting that Poems (1949) was defective in contents, in ordering, and in text. I trust the validity of that statement has now been demonstrated. For over three decades Poems had been considered “The Definitive Edition”, the question of the order of Last Poems the only possible flaw on its unblemished surface. Yet it is now clear that Poems was not only Yeats’s edition but also that of his wife and his editor at Macmillan. They preferred the 1932 proofs for the Edition de Luxe over later and revised texts. They regularised punctuation according to their own standards and solicited suggestions for similar improvements. They decided on the matter of including “Three Songs to the Same Tune” by a committee vote. They wilfully violated what they knew to be Yeats’s plan for the order of Last Poems. And so forth.
The economics of old field oil supply

Analyse econometrique de la relation entre les prix du petrole brut, les taxes, les couts d'exploitation et les reserves prouvees ainsi que la productivite des puits. L'etude est realisee sur des donnees statistiques des annees 1970-1986, relatives aux Etats-Unis
Chronic Kidney Disease in the Elderly - Who Has it? Who Does One Treat and How are They to be Treated?

The prevalence of CKD in the elderly is rising worldwide with the potential for tremendous individual and societal burdens. Accurate diagnosis of CKD by GFR estimation equations is improving, with refinements to diagnosis and prognosis achieved with quantification of albuminuria. Increasing scientific discovery of the causes of kidney senescence and eventual development of strategies to reduce progressive renal loss will be key elements of nephrologic care in the future. Management of the failing kidney of elderly patients requires thoughtful consideration and planning. Determination of illness trajectory, functional status, as well as establishing goals of care are essential considerations for the caring nephrologist. Nephrologists should be aware of the risks and benefits of renal replacement therapy and how to implement conservative and palliative care in treatment of elderly patients with advancing renal disease.
Advanced reactor instrumentation and control reliability and risk assessment

Advanced nuclear power reactors will use different approaches to achieving a higher level of safety than the first generation. One approach uses the technological developments in computation and electronics in the form of digital instrumentation and control (I&C) to enhance the reliability and accuracy of information for plant control, responding to the information, and controlling the plant and its systems under normal and upset environments in various states of degradation. Evaluating the reliability and safety of advanced I&C systems requires determining the reliability of the I&C used in the advanced reactors, which involves distributed processing, data pile-up, interactive systems, the man-machine interface, various forms of automatic control, and systems interactions. From these analyses will come an understanding of the potential of the new I&C, and protection from its vulnerabilities to enhance the safe operation of the new plants. Technological, safety, reliability, and regulatory issues associated with advanced I&C for the new reactors are discussed, and suggested approaches to their resolution are presented. >
Self-Reflection, Politics, Art, and Qualitative Research: A Review of Denzin and Lincoln’s Third Edition of Collecting and Interpreting Qualitative Materials

The third edition of Collecting and Interpreting Qualitative Materials, edited by Norman K. Denzin and Yvonna S. Lincoln, illustrates the varied perspectives of twenty five experienced qualitative researchers focusing on collecting, analyzing, and interpreting empirical materials. New topics are introduced in this third edition capturing the dynamic nature and emerging trends in the field such as arts-based approaches. It is a great reference book and a resource of unlimited possibilities. It provides a window for further inquiry for beginners, intermediate and experienced qualitative researchers. Many of the chapters read as powerful essays provoking self-reflection, political involvement, activism, and alternate ways of looking at the world around us.
Is this the wave of the future? Examining the psychometric properties of child behavior ratings administered online

Online data collection is increasingly utilized in the field of psychology. While there is a growing literature regarding the advantages of computer-based data collection, little is known regarding the psychometric comparability of measures across computer-based and traditional paper-and-pencil administration methods. This is especially true with regard to caregiver-report ratings of childrens behavioral, academic, and emotional functioning. In this between-subjects study, the psychometric properties of caregiver behavioral, academic, and emotional functioning ratings for youth between the ages of 5 and 18 representing a mixed clinical sample were compared across computer-based (online group; n=3831) and paper-and-pencil (PP n=514) administration formats. Groups differed on sex, age, and rater education distributions. Controlling for these variables, no statistically significant differences between groups were found in terms of symptomatology. In terms of psychometric characteristics, no group differences were found on inter-item reliability for any measure, and inter-item reliability for all scales across groups fell within the acceptable range. Similarly, comparisons of factor loadings across groups indicate marked consistency in the psychometric structure of all measures across administration formats. These results suggest that, regardless of administration method, the psychometric properties of caregiver ratings of childrens behavioral, academic, and emotional functioning remain consistent. Caregiver ratings of symptom severity do not vary by administration format.Inter-item consistency is comparable across administration formats.Factor structure of all measures is consistent across administration formats.
Functional activity of the sensorimotor cortex and cerebellum relates to cervical dystonia symptoms

Cervical dystonia (CD) is the most common type of focal dystonia, causing abnormal movements of the neck and head. In this study, we used noninvasive imaging to investigate the motor system of patients with CD and uncover the neural correlates of dystonic symptoms. Furthermore, we examined whether a commonly prescribed anticholinergic medication in CD has an effect on the dystonia-related brain abnormalities. Participants included 16 patients with CD and 16 healthy age-matched controls. We collected functional MRI scans during a force task previously shown to extensively engage the motor system, and diffusion and T1-weighted MRI scans from which we calculated free-water and brain tissue densities. The dystonia group was also scanned ca. 2 h after a 2-mg dose of trihexyphenidyl. Severity of dystonia was assessed pre- and post-drug using the Burke-Fahn-Marsden Dystonia Rating Scale. Motor-related activity in CD was altered relative to controls in the primary somatosensory cortex, cerebellum, dorsal premotor and posterior parietal cortices, and occipital cortex. Most importantly, a regression model showed that increased severity of symptoms was associated with decreased functional activity of the somatosensory cortex and increased activity of the cerebellum. Structural imaging measures did not differ between CD and controls. The single dose of trihexyphenidyl altered the fMRI signal in the somatosensory cortex but not in the cerebellum. Symptom severity was not significantly reduced post-treatment. Findings show widespread changes in functional brain activity in CD and most importantly that dystonic symptoms relate to disrupted activity in the somatosensory cortex and cerebellum. Hum Brain Mapp 38:4563-4573, 2017. © 2017 Wiley Periodicals, Inc.
Complete regression of cutaneous metastases with systemic immune response in a patient with triple negative breast cancer receiving p53MVA vaccine with pembrolizumab

A heavily pretreated patient with triple negative breast cancer distinguished by cutaneous metastases received p53MVA vaccine in combination with pembrolizumab. Her cutaneous metastases regressed and after 2 cycles of therapy, a skin biopsy showed a complete pathological response. Systemic response was confirmed with restaging CT and bone scans. Activation of p53-specific T cell responses and elevation of multiple immune response genes in peripheral blood correlated with the rapid clinical response which lasted for 6 months after the initiation of combined therapy.
Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons

Abstract RNA binding motif 5 (RBM5) is a nuclear protein that modulates gene transcription and mRNA splicing in cancer cells. The brain is among the highest RBM5-expressing organ in the body but its mRNA target(s) or functions in the CNS have not been elucidated. Here we knocked down (KO) RBM5 in primary rat cortical neurons and analyzed total RNA extracts by gene microarray vs. neurons transduced with lentivirus to deliver control (non-targeting) shRNA. The mRNA levels of Sec23A (involved in ER-Golgi transport) and the small GTPase Rab4a (involved in endocytosis/protein trafficking) were increased in RBM5 KO neurons relative to controls. At the protein level, only Rab4a was significantly increased in RBM5 KO extracts. Also, elevated Rab4a levels in KO neurons were associated with decreased membrane levels of oligomeric serotonin transporters (SERT). Finally, RBM5 KO was associated with increased uptake of membrane-derived monomeric SERT. Significance: Rab4a is involved in the regulation of endocytosis and protein trafficking in cells. In the CNS it regulates diverse neurobiological functions including (but not limited to) trafficking of transmembrane proteins involved in neurotransmission (e.g. SERT), maintaining dendritic spine size, promoting axonal growth, and modulating cognition. Our findings suggest that RBM5 regulates Rab4a in rat neurons.
Conditions for endemicity: qualitative population dynamics in a long-running outbreak of Ebola virus disease

AbstractEbola virus disease (EVD) struck West Africa in 2013–2016 in an epidemic of unprecedented scope, with over 28000 cases and 11000 fatalities in the affected region. The protracted duration of the outbreak – more than two-and-one-half years of active transmission – raises questions about the persistence of EVD. In this brief paper, we qualitatively examine conditions supporting long-running EVD epidemics via a susceptible – exposed – infectious – recovered – deceased-infectious differential equations model that incorporates births and non disease-related deaths. We define an ‘effective epidemiological population’ to include contagious individuals recently deceased from the disease. Under a constant effective epidemiological population condition, we consider the basic reproductive number and use Lyapunov function arguments to establish conditions in the parameter space supporting an exchange of stability from the disease-free equilibrium to an endemic equilibrium.
Estimating main and interaction effects of a multi-component randomized controlled trial via simulation meta-heuristics

Randomized controlled trials often are conducted on multi-component interventions in all-or-none manners for practical, logistic, or statistical purposes, typically allowing researchers the ability only to estimate the overall effect of the intervention en masse. In parallel, we propose a simulation-based approach to estimate main and interaction effect sizes of an intervention's sub-components based on conducting meta-heuristic parameter search on intra-trial longitudinal input, output, and context data. This approach is illustrated with a recent application to a healthcare intervention consisting of three information technology patient safety tools tested as a single intervention in a multi-unit staggered cluster crossover RCT design, with the overall objective being to reduce falls, infections, and other adverse events. (AEs) A high fidelity simulation of individual and combined use of these tools was developed and validated with retrospective data and then applied to prospective longitudinal data as clinical units varied in occupancy, staffing, patient risk, care team composition, and tool adherence, with parameter search estimating main and interaction effect sizes to maximally reproduce observed data. Computational results and implications are discussed.
Development of Sparganothis sulfureana (Lepidoptera: Tortricidae) on Cranberry Cultivars.

Sparganothis fruitworm (Sparganothis sulfureana Clemens) (Lepidoptera: Tortricidae) is a serious pest of cranberry (Vaccinium macrocarpon Aiton), a native North American fruit cultivated in northern regions of the United States and southeastern Canada. This study assessed antibiosis in several cranberry cultivars commonly grown in Wisconsin. Five cultivars previously shown to host different levels of populations of S. sulfureana in commercial cranberry were assessed in this study to evaluate the performance of S. sulfureana amongst these cultivars. We measured growth and time to developmental stages of newly emerged larvae to adulthood on selected cranberry cultivars in the laboratory. There was no difference in the rates of survival to pupation and to adult emergence among any of the cultivars tested. Mid-instar larvae that fed on the cultivar ‘Ben Lear’ were heavier than those feeding on ‘GH-1’, ‘Stevens’, or ‘HyRed’, and larvae that fed on ‘Mullica Queen’ were heavier than those feeding on ‘HyRed’. However, there were no significant differences in pupal weights or in the number of days from neonate to adult emergence among varieties. Therefore, this study did not provide evidence of antibiosis among the cultivars tested, and found that larval weight was not correlated with other measurements of performance.
Classifying physiographic regimes on terrain and hydrologic factors for adaptive generalization of stream networks

Automated generalization software must accommodate multi-scale representations of hydrographic networks across a variety of geographic landscapes, because scale-related hydrography differences are ...
Energy-delay-secrecy tradeoffs in wireless communications under channel uncertainty

In this paper, energy-efficient and secure communication over wireless fading channels is investigated when data arrivals are modeled as Markovian processes (e.g., discrete Markov and Markov fluid processes) in the presence of limitations on buffer overflow probabilities. It is assumed that the transmitter knows only the distributions of the fading coefficients in both the eavesdropper's and legitimate user's channels. Consequently, data transmissions occur at fixed rates, with secrecy outage happening when the instantaneous secrecy capacity is less than the fixed rate. In this setting, by employing the effective bandwidth and effective capacity formulations, throughput expressions are derived, and energy efficiency metrics, namely minimum energy per bit and wideband slope, are determined. Overall, the impact of source and channel variations as well as the delay quality of service (QoS) requirements on the energy efficiency of secure communications is identified.
Facilitation of ab interno radial keratotomy by air keratoplasty.

Background Ab interno radial keratotomy is a keratorefractive procedure with radial incisions made by externalizing a blade inserted in the deep stroma. A major limitation of the procedure is the technical inability to establish a safe pre-Descemetic stromal entry of the blade with subsequent suboptimal depth of the radial incisions. A technique to delineate Descemet's membrane was investigated to obtain deeper incisions with the ab interno radial keratotomy. Methods Air was injected with a 30-gauge needle mounted on a 3-milliliter syringe and entering the deep stroma at the limbus in human donor eyes. The injection was done in a pulse fashion with the needle tip advanced 3 mm away from the limbus. Ab interno radial keratotomy was then performed with and without air injection. Results Bubbles were localized to the pre-Descemet region. The depth of the radial keratotomy incisions increased from 57.7% (SD = 11.5%) without air injection, to 83.0% (SD = 10.6%) with air injection. Conclusions Deep stromal air injection delineates the pre-Descemet space, allowing deeper radial incisions with the ab interno radial keratotomy.
Kinship and Aesthetic Depth: The Tableau Vivant in Goethe’s Wahlverwandtschaften

ABSTRACTJohann Wolfgang Goethe famously includes performances of tableaux vivants in Die Wahlverwandtschaften. The tableau vivant bridges social classes, kinship models, and aesthetic media (painti...
Two new integrable Kadomtsev-Petviashvili equations with time-dependent coefficients: multiple real and complex soliton solutions

In this work, we develop two new integrable Kadomtsev–Petviashvili (KP) equations with time-dependent coefficients. The integrability property of each equation is explicitly demonstrated exhibiting...
Novel nest construction behavior in Gray Vireos (Vireo vicinior)

ABSTRACT The Gray Vireo (Vireo vicinior) is currently listed as threatened in New Mexico (USA), and detailed observations of its breeding behavior are limited. Like other vireos, the Gray Vireo bui...
Venous Physiology Predicts Dehydration in the Pediatric Population

Abstract Background No standard dehydration monitor exists for children. This study attempts to determine the utility of Fast Fourier Transform (FFT) of a peripheral venous pressure (PVP) waveform to predict dehydration. Materials and methods PVP waveforms were collected from 18 patients. Groups were defined as resuscitated (serum chloride ≥ 100 mmol/L) and hypovolemic (serum chloride Results Admission FFTs were compared between 10 (56%) resuscitated and 8 (44%) hypovolemic patients. The PVP signal power was higher in resuscitated patients (median 0.174 mmHg, IQR: 0.079-0.374 mmHg) than in hypovolemic patients (median 0.026 mmHg, IQR: 0.001-0.057 mmHg), (P Conclusions FFT of PVP waveforms can predict dehydration in hypertrophic pyloric stenosis. Further work is needed to determine the utility of PVP analysis to guide fluid resuscitation status in other pediatric populations.
3D Positional Movement Interaction with User-Defined, Virtual Interface for Music Software: MoveMIDI

This paper describes progress made in design and development of a new digital musical instrument (MIDI controller), MoveMIDI, and highlights its unique 3D positional movement interaction design differing from recent orientational and gestural approaches. A user constructs and interacts with MoveMIDI's virtual, 3D interface using handheld position-tracked controllers to control music software, as well as non-musical technology such as stage lighting. MoveMIDI's virtual interface contributes to solving problems difficult to solve with hardware MIDI controller interfaces such as customized positioning and instantiation of interface elements, and accurate, simultaneous control of independent parameters. MoveMIDI's positional interaction mirrors interaction with some physical acoustic instruments and provides visualization for an audience. Beta testers of MoveMIDI have created emergent use cases for the instrument.
The dual-hormone hypothesis: a brief review and future research agenda

The dual-hormone hypothesis posits that testosterone's role in status-relevant behavior should depend on concentrations of cortisol, a hormone released in response to physical and psychological stress. This paper (i) reviews evidence for the dual-hormone hypothesis on measures of dominance, aggression, social status, risk-taking, and economic decision-making; (ii) discusses contextual and individual difference moderators of dual-hormone associations with behavior; and (iii) outlines key directions for future research. Together, this review points to promising support for the dual-hormone hypothesis across multiple behavioral domains relevant to the pursuit and maintenance of social status.
Primary plasma cell leukemia: A case report and review of the literature

Due to the rarity and fulminant nature of the condition, there are limited data driving dialogue for optimal treatment strategies for plasma cell leukemia (PCL). Additionally, the current diagnostic definition of PCL has not been prospectively studied which may result in delays to initiating early aggressive treatment due to underdiagnosis.
Validation of Abbreviated Four- and Eight-Item Versions of the PTSD Checklist for DSM-5 in a Traumatically Injured Sample

Rates of posttraumatic stress disorder (PTSD) are three times higher in traumatically injured populations than the general population, yet limited brief, valid measures for assessing PTSD symptom severity exist. The PTSD Checklist for DSM-5 (PCL-5) is a valid, efficient measure of symptom severity, but its completion is time consuming. Subsequently, abbreviated four- and eight-item versions were developed using the Mini-International Neuropsychiatric Interview-7 PTSD module and validated in Veteran samples. This study aimed to validate these abbreviated versions using the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), the gold standard for PTSD diagnosis, in a traumatically injured civilian population. Participants were 251 traumatically injured adults (Mage = 42.52 years; 69.3% male; 50.2% Caucasian) recruited from a Level 1 trauma center inpatient unit; 32.3% and 17.9% of participants experienced a motor vehicle crash or gunshot wound, respectively. The CAPS-5 and PCL-5 were administered approximately 6.5 months postinjury. We examined whether compared to the full PCL-5, the abbreviated versions would adequately differentiate between participants with and without a CAPS-5 PTSD diagnosis. The abbreviated versions were highly correlated with the total scale and showed good-to-excellent internal consistency. The diagnostic utility of the abbreviated measures was comparable to that of the total scale regarding sensitivity, suggesting they may be useful as abbreviated screening tools; however, the total scale functioned better regarding specificity. The abbreviated versions of the PCL-5 may be useful screening instruments in the long-term care of traumatic injury survivors and may be more likely to be implemented across routine clinical and research contexts.
Mild COVID-19 in a pediatric renal transplant recipient.

As of mid-April 2020, the coronavirus disease of 2019 (COVID-19) pandemic has affected more than 2 million people and caused 135 000 deaths worldwide. Not much is known about the effect of this disease in immunosuppressed children with renal transplantation (RT). Here we report a 13-year-old child with multiple comorbidities who acquired COVID-19 5 years post-RT in the United States. Maintenance immunosuppression (IS) consisted of sirolimus and mycophenolate. There was no history of travel or exposure to sick contacts. The presenting features were fever, cough, rhinorrhea, and hypoxemia. Diarrhea was the only extrapulmonary manifestation. Chest X-ray was normal. He did not require intensive care unit care or ventilation. There was a transient rise in his serum creatinine without change in urine output; dialysis was not required. Slight reduction in IS was done. He had an excellent clinical recovery within 4 days and was able to be discharged home. His respiratory symptoms resolved but the diarrhea persisted during a 4-week follow-up period. This report provides a brief perspective on the short-term COVID-19 clinical course in an immunosuppressed child. More reports will add valuable information on the potential variety of spectrum of the illness in this subset of children.
Determination of effective attenuation length of slow electrons in polymer films

Slow electrons (with energy below 10 eV) play an important role in nature and technology. For instance, they are believed to initiate solubility change in extreme ultraviolet resists. Depending on their mobility, such secondary electrons can lead to image blur and degradation of patterning resolution. Hence, it is important to characterize the transport of slow electrons by measuring parameters such as the effective attenuation length (EAL). We present a technique that allows for prompt characterization of EAL in polymer films. In this experiment, slow electrons are generated in a substrate upon absorption of x-ray photons. The attenuation of electron flux by a polymer film is measured as a function of film thickness, allowing for the determination of EAL for slow electrons. We illustrate this method with poly(hydroxy styrene) and poly(methyl metacrylate) films. Furthermore, we propose an improvement for this technique that would enable the measurement of EAL as a function of electron kinetic energy.
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers

Enteric bacteria and/or their products are necessary for doxorubicin (DXR)-induced small intestine mucosal damage. While DXR does not induce gross loss of epithelium, others have shown elevated serum endotoxin after DXR administration. However, the mechanism of movement is unknown. We hypothesized that DXR treatment resulted in increased paracellular translocation of bacteria or bacterial products through the small intestinal epithelium. We measured permeability after DXR administration using transepithelial resistance and macromolecular flux and assessed tight junctional gene expression and protein localization both in vitro using T84 cells and ex vivo using murine jejunum. DXR treatment increased flux of 4 kDa dextrans in mouse jejenum, but increased flux of 4, 10 and 20 kDa dextrans in T84 cells. Following DXR, we observed increased permeability, both in vitro and ex vivo, independent of bacteria. DXR induced increased expression of Cldn2 and Cldn4 in murine small intestine but increased only CLDN2 expression in T84 cells. DXR treatment induced disorganization of tight junctional proteins. We conclude that DXR increases paracellular transit of small macromolecules, including bacterial products, through the epithelium, by altering expression of tight junctional components and dynamic loosening of cellular tight junctions.
Sex differences in outcomes after arthroscopic bankart repair.

Objectives Risk factors for anterior shoulder dislocation include young age, contact activities and male sex. The influence of sex on patient-reported outcomes of arthroscopic Bankart repair (ABR) is unclear, with few studies reporting potential differences. This study’s purpose was to compare patient-reported outcomes of males and females following ABR. Methods Prospectively collected data was analysed for 281 patients (males: 206, females: 75) after ABR with preoperative, 1-year and 2-year follow-up responses. The Wilcoxon signed-rank and χ2 tests, preoperative, 1 year and 2 year follow-up results were examined to determine differences of scores in males versus females. Results No statistically significant sex differences were observed in Simple Shoulder Test (SST), American Shoulder and Elbow Surgeons (ASES), Visual Analogue Scale (VAS) or Single Assessment Numerical Evaluation (SANE) Scores at 1-year or 2-year follow-up. Females had lower Veterans RAND 12-item health survey (VR-12) mental health subscores at 2-year follow-up (females: 52.3±9.0, males: 55.8±7.6, p=0.0016). Females were more likely to report that treatment had ‘exceeded expectations’ at 2-year follow-up regarding motion, strength, function and normal sports activities. Conclusion Results of study demonstrate that ABR has similar outcomes for both males and females. There were no statistically significant sex-related differences in SST, ASES, VAS or SANE scores following ABR. VR-12 mental health subscores showed a minimal difference at 2-year follow-up, with lower scores in females. Level of evidence Retrospective cohort study; level II.
Collaboration, Venus, and Mars: The Gender Factor in Intersectoral Relations

Scholarship across disciplines offers evidence that gender plays a significant role in organizational dynamics. Gender differences in preferences, attitudes, and behaviors affect employee behavior and organizational outcomes. This article extends the gender factor into the realm of interorganizational and intersectoral collaboration to examine not just whether, but also how gender affects the management of these relationships. We analyze these differences in the context of local government–nonprofit organization (NPO) relations in a developing country with data from two 2017 nationally representative surveys of local governments and NPOs in Lebanon. Our results suggest that in male-dominated nations like Lebanon, females leading local government organizations are less likely to enter into cross-sector collaborations than their male counterparts, and in the nonprofit sector, gender plays no significant role in the decision to collaborate. However, among existing collaborations, females, as compared with males, have been more likely to both initiate and fund the interorganizational/intersectoral relationships. These results contribute to the literature on gender, management, and intersectoral collaboration, and offer an agenda for future scholarship on these topics.
Intact Correction for Self-Produced Vowel Formant Variability in Individuals With Cerebellar Ataxia Regardless of Auditory Feedback Availability.

Purpose Individuals with cerebellar ataxia (CA) caused by cerebellar degeneration exhibit larger reactive compensatory responses to unexpected auditory feedback perturbations than neurobiologically...
Southern (American) Hospitality: Italians in Argentina and the United States During the Age of Mass Migration

Argentina and the United States were the principal destinations for Italian immigrants during the Age of Mass Migration. I assemble data following Italians from passenger lists to censuses in Argentina and the United States, enabling me to compare the economic outcomes of migrants with similar pre-migration characteristics but who moved to different countries. Italians assimilated faster in Argentina, and this advantage was unlikely to be due to selection. A higher human capital relative to natives and the Italian-Spanish similarity largely explain Italians’ advantage in Argentina. These findings highlight the importance of the fit between migrants’ characteristics and those of the receiving country.
Altering magnetic properties of iron filament PLA using magnetic field assisted additive manufacturing (MFAAM)

Abstract Three different samples of soft magnetic material Proto-pasta, a composite of iron and polylactic acid (PLA), were printed in the presence of a magnetic field and then measured using a vibrating sample magnetometer (VSM) to inspect the effects printing in a magnetic field has on the samples’ magnetic properties. Multiple hysteresis measurements were taken with respect to the field angle for each sample printed in various fields to observe the changes in hysteresis loss and susceptibility. The Fe/PLA composites printed using Magnetic Field Assisted Additive Manufacturing (MFAAM) displayed a susceptibility approximately twice as large as the composites printed in zero field. Through varying field angle VSM measurements, the inspected susceptibility also displayed anisotropy, having a magnitude 2.7 times larger when measured along the print field.
Contradiction and Change in Organized Religion

At midcentury, to be American was to be confidently Protestant, Catholic, or Jew (Herberg, 1955). True elites were WASP by birthright, but Catholics and Jews were accepted as part of the mainstream and nonaffiliation was simply un-American. Institutional religion in the United States was not only the heart of the “American Way of Life,” but its moral conscience, political legitimator, and economic backbone as well. Church religion was not isomorphic with civil religion, to be sure, but they were comfortable bed partners (Bellah, 1968).
A Wigner Function Study of Magnetotunneling

The Wigner function formalism for quantum transport is used to study the magnetoconductance of single-barrier tunneling structures. We use a Gaussian wave packet to numerically simulate a single electron in two spatial dimensions, and study the skipping orbits of the electron wave packet resulting from the combined interactions of the magnetic field and the tunneling barrier. We find that transmission through a barrier leads to a packet that is split into different skipping orbits.