cssi/SciSciGPT-SciSciNet huggingface dataset:
Sociotechnical Perspective on Implementing Clinical Video Telehealth for Veterans with Spinal Cord Injuries and Disorders.

Abstract Background: Real-time videoconferencing technology such as clinical video telehealth (CVT) offers a means to reach patient populations who face limited access to healthcare. The Veterans Health Administration has invested in CVT to improve care access for U.S. military veterans with spinal cord injuries and disorders (SCI/D); however, no studies have assessed the factors that influence implementation of this technology in clinical practice for individuals with SCI/D. Introduction: Guided by a sociotechnical perspective, the purpose of this study was to identify factors that influence implementation of CVT for veterans with SCI/D. Materials and Methods: We conducted semistructured telephone interviews with 40 healthcare providers who use CVT to deliver services to veterans with SCI/D. Results: Factors related to workflow and communication were widely reported as implementation barriers. Coordinating logistics for CVT appointments was challenging, and effective communication between CVT team member...
Psychosocial correlates of sleep architecture in women with advanced breast cancer.

9051 Background: Sleep disturbance is prevalent among metastatic breast cancer (MBC) patients and few studies have objectively evaluated this problem using polysomnography (PSG). Disturbed sleep negatively affects quality of life. The current study examines the relationship of mood and family structure with sleep parameters assessed over three nights of PSG (2 at-home, 1 in-lab). Methods: MBC patients (n = 103) and healthy controls (n = 27) were recruited. Patients were 57.8 years (SD = 7.7), non-Hispanic white (86.3%), and had Karnofsky ratings of at least 70%. Multiple regression analyses assessed relationships among depression, cohabitation, and sleep parameters. Results: Among patients, sleep architecture was significantly related to depression and marital status/cohabitation. Women reporting more depressive symptoms had less deep sleep: lower percentage (B = -.26, p = .01) and fewer minutes of REM (B = -.23, p = .02), lower % (B = -.25, p = .02) and fewer minutes of stage 2 sleep (B = -.28, p = .01),...
Propagating discrete breathers in forced one-dimensional granular networks: theory and experiment

We study propagating discrete breathers in forced one-dimensional nonlinear granular media on linear elastic foundations, with no pre-compression. These are modulated oscillatory travelling wavepackets that are formed due to the dynamical balance between the strongly nonlinear Hertzian interactions between the beads of the granular chain, the dispersion caused by the on-site elastic potential, and the intrinsic discreteness of the medium. In the theoretical part of this study we consider granular chains with and without dissipative terms. We analytically prove the existence of breathers in harmonically forced granular chains governed by nonlinear combination resonances in the forced dynamics. Our analytical models predict the speed and frequency contents of the discrete breathers which are validated by direct computational results. We show the existence of countable infinities of breathers in these systems corresponding to higher-order resonances between the applied harmonic excitations and the intrinsic frequency components of the modulated wavepackets. These families are energy-dependent and tunable with the harmonic excitation. Finally, we experimentally validate the theoretical results with a fixture that is designed to realize robustly the predicted propagating breathers. Considering impulsive excitations we experimentally verify the energy tunability of the breathers, and compare the experimental results to computational reconstructions of the results. These findings pave the way for designing granular chains for predictable and focused energy transmission.
Are Taxes Converging

Eduardo Baistrocchi’s outstanding new book on tax treaty disputes is the result of an intense five-year global collaborative project among international tax scholars, practitioners and administrators. The book provides an unprecedented set of information and offers the first global qualitative and quantitative analysis on one of the most important debates over international tax scholarship across the last decades, that is, whether an international tax regime exists and is binding upon states as a matter of customary international law.
Abstract A18: Predicting synergistic drug combinations from genomic features and single-agent response profiles

Drug combinations promise to improve clinical responses and/or forestall drug resistance. To capitalize on this promise, we need to know which drugs to combine, and whom to give them to based on the genetic or pathological features of their disease. However, accomplishing this goal has been precluded by the infeasibility of performing comprehensive drug-combination studies across thousands of cellular contexts. We hypothesized that the basal gene-transcription state of cancer cell lines, in concert with the response profiles of hundreds of single-agent small molecules, might be leveraged to nominate synergistic drug combinations, eliminating the need to test all possible drug/drug combinations across cellular models. Specifically, we predicted that inhibiting the protein product of transcripts associated with drug resistance to a given small molecule might induce drug synergy. To test this notion, we analyzed public cell-line drug-sensitivity data to identify candidate compound-gene pairs. We identified 7 examples in which outlier expression of a druggable candidate protein was associated with lack of single-agent response. Inhibition of 6/7 candidate co-targets resulted in cell-line-specific synergistic cell killing across multiple cell line models, validating the overall approach. For example, consistent with clinical findings, we found that high expression of the MGMT gene, encoding O-6-methylguanine-DNA methyltransferase, was uniquely associated with response to alkylating agents such as temozolomide, and that combination of the MGMT inhibitor O-6-benzylguanine with temozolomide resulted in synergistic killing. These initial studies highlight the potential of integrating basal gene expression features with small-molecule response to nominate rational candidates for drug combinations. As public repositories of single-agent response data from diverse cellular contexts continue to expand, so too will our repertoire of therapeutic combinations. Moreover, this approach permits the parallel identification of genomic features that indicate which patient populations are most likely to benefit from such combinations. Citation Format: Matthew G. Rees, Lisa Brenan, Amanda Walker, Cory M. Johannessen. Predicting synergistic drug combinations from genomic features and single-agent response profiles [abstract]. In: Proceedings of the AACR Precision Medicine Series: Opportunities and Challenges of Exploiting Synthetic Lethality in Cancer; Jan 4-7, 2017; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2017;16(10 Suppl):Abstract nr A18.
Grain-boundary displacement vs grain deformation as the rate-determining factor in creep

The height of the vertical grain-boundary displacements was measured on creep specimens of β-brass. The displacements followed a normal distribution whose standard deviation was a function of strain and was independent of temperature from 450° to 501°C. The strength of the grain, not the shear resistance of the boundary, was found to be the rate-controlling factor in the creep of β-brass.
NAFLD in 2017: Novel insights into mechanisms of disease progression.

In 2017, there have been substantial advances in our understanding of the immunological and endocrine mechanisms of disease progression in NAFLD, paving the way for novel therapeutic strategies.
Use of Antipsychotic Drugs for Psychotic Disorders in Children

This review aims to provide evidence-based guidance regarding the use of antipsychotic medications for treatment of children and adolescents with psychotic disorders. Research findings from the past 3 years are emphasized. A number of studies have demonstrated the efficacy of antipsychotic medications for use in children and/or adolescents with psychotic disorders, but there is also high potential for significant side effects. Atypical antipsychotic drugs are often preferred instead of typical antipsychotics due to reduced risk of extrapyramidal symptoms, but the risk for weight gain and metabolic side effects is a particular concern with atypical antipsychotic drugs. Several antipsychotics are now FDA approved for the treatment of schizophrenia in the pediatric population, including the atypical antipsychotics aripiprazole, lurasidone, olanzapine, paliperidone, quetiapine, and risperidone. Although clozapine is not FDA approved for use in the pediatric population, and children may be more susceptible to serious side effects from this medication, studies have demonstrated its efficacy in treating early-onset schizophrenia. A recently reported rare but potentially serious side effect of the third-generation antipsychotic aripiprazole is new-onset impulse control symptoms (such as compulsive gambling and sexual urges), but there is not enough information available to show whether this particular adverse event is as common in children as in adults. Although the use of antipsychotic drugs is appropriate to control symptoms of early-onset primary psychotic disorders, the potential for medically significant side effects from these drugs warrants a need for careful diagnostic evaluation prior to starting antipsychotics in children, followed by careful monitoring and management of adverse events that may occur during treatment. Further research is needed to determine the relative efficacy of treatment options, investigate the value of polypharmacy, and develop methods of preventing and managing adverse effects.
A megahertz-frequency tunable piecewise-linear electromechanical resonator realized via nonlinear feedback

Abstract Vibration-based sensing modalities traditionally have relied upon monitoring small shifts in natural frequency in order to detect structural changes (such as those in mass or stiffness). In contrast, bifurcation-based sensing schemes rely on the detection of a qualitative change in the behavior of a system as a parameter is varied. This can produce easy-to-detect changes in response amplitude with high sensitivity to structural change, but requires resonant devices with specific dynamic behavior which is not always easily reproduced. Desirable behavior for such devices can be produced reliably via nonlinear feedback circuitry, but has in past efforts been largely limited to sub-MHz operation, partially due to the time delay limitations present in certain nonlinear feedback circuits, such as multipliers. This work demonstrates the design and implementation of a piecewise-linear resonator realized via diode- and integrated circuit-based feedback electronics and a quartz crystal resonator. The proposed system is fabricated and characterized, and the creation and selective placement of the bifurcation points of the overall electromechanical system is demonstrated by tuning the circuit gains. The demonstrated circuit operates at 16 MHz. Preliminary modeling and analysis is presented that qualitatively agrees with the experimentally-observed behavior.
Governance Choice - A Theoretical Analysis

Policy debate has lasted over the past twenty years regarding the distribution of federal highway funding in the US Federal-Aid Highway Program. The controversy arose as the program’s payment to the individual states did not match the amount of federal highway taxes each state’s highway users pay to the Highway Trust Fund (HTF), which is commonly referred to as the “donor-donee” problem (Kirk, 2004). Donee states like Alaska experience high returns from the HTF, donor states like California contribute more than they receive, while some states like Ohio have experienced instability and cycling in terms of their donor/donee status. In general, the allocation of federal highway funds appears to be based on formulas that are biased in favor of states with relatively low highway use to maintain national integration (Johnson and Libecap, 2000). In such an imbalanced allocative program, a fiscal correspondence problem arises when policy makers in donee states spend to benefit their constituent travelers and suppliers, but whose welfare costs are borne by taxpayers in all the states.
Programs and Computable Functions

This chapter discusses programs and computable functions. Computability theory is based on a specific programming language. Certain letters are used as variables whose values are numbers. In particular, the letter X 1 , X 2 , X 3 are called the input variables of a programming language, Y is called the output variable, and Z 1 , Z 2 , Z 3 , etc. are called local variables. Thus from the outset, programming language must be regarded as a purely theoretical entity. The execution of the program has the effect of increasing the value of X by 2. In addition to variables, one will also need labels. GOTO L is not an instruction in programming language but as it is frequently used for an instruction, one can use it as an abbreviation for the program segment. Such an abbreviating pseudo instruction is called a macro and the program or program segment that it abbreviates is called its macro expansion. The use of these terms is obviously motivated by similarities with the notion of a macro instruction occurring in many programming languages.
Association between heart rate variability and manual pulse rate.

Introduction One model for neurological assessment in chiropractic pertains to autonomic variability, tested commonly with heart rate variability (HRV). Since HRV may not be convenient to use on all patient visits, more user-friendly methods may help fill-in the gaps. Accordingly, this study tests the association between manual pulse rate and heart rate variability. The manual rates were also compared to the heart rate derived from HRV. Methods Forty-eight chiropractic students were examined with heart rate variability (SDNN and mean heart rate) and two manual radial pulse rate measurements. Inclusion criteria consisted of participants being chiropractic students. Exclusion criteria for 46 of the participants consisted of a body mass index being greater than 30, age greater than 35, and history of: a) dizziness upon standing, b) treatment of psychiatric disorders, and c) diabetes. No exclusion criteria were applied to the remaining two participants who were also convenience sample volunteers. Linear associations between the manual pulse rate methods and the two heart rate variability measures (SDNN and mean heart) were tested with Pearson's correlation and simple linear regression. Results Moderate strength inverse (expected) correlations were observed between both manual pulse rate methods and SDNN (r = -0.640, 95% CI -0.781, -0.435; r = -0.632, 95% CI -0.776, -0.425). Strong direct (expected) relationships were observed between the manual pulse rate methods and heart rate derived from HRV technology (r = 0.934, 95% CI 0.885, 0.962; r = 0.941, 95% CI 0.897, 0.966). Conclusion Manual pulse rates may be a useful option for assessing autonomic variability. Furthermore, this study showed a strong relationship between manual pulse rates and heart rate derived from HRV technology.
An animal behavior model for decreased central serotonergic function.

Progress in understanding various behavioral and functional aspects of chemical neurotransmission has frequently been facilitated by the use of models of these processes. Ideally, such models provide an objective and quantifiable index of the synaptic activity of a specific neurotransmitter, either in a particular locus or, more generally, of an entire neurochemical system.
Race is a Predictor of Withdrawal of Life Support in Patients with Intracerebral Hemorrhage

Abstract Introduction: Medical and socioeconomic factors may impact decisions to change the goals of care for patients with intracerebral hemorrhage (ICH) to comfort measures only. Methods: We reviewed prospectively collected data on patients with ICH, including baseline patient demographics, Glasgow Coma Scale (GCS), National Institute of Health Stroke Scale (NIHSS), and ICH score. We conducted multivariable logistic regression analysis to identify predictors of change to comfort measures only status. Results: Of 198 patients included in the analysis, 39 (19.7%) were made comfort measures only. Age, gender, insurance status, substance use, and medical comorbidities were similar between groups. Race was significantly different between the comfort measures only (black 15.4%, white 51.3%, other 33.3%) and noncomfort measures only groups (black 39.6%, white 45.9%, other 14.5%; P = .003). Patients changed to comfort measures only had higher mean income based on zip code ($59,264 versus $49,916; P = .021), higher median NIHSS (23 versus 16; P = .0001), higher ICH score (2.7 versus 1.5; P
A Metacognitive Model of Writing: An Update From a Developmental Perspective

In this article, writing is reconceptualized as primarily a metacognitive process that can be modeled using contemporary metacognitive theory. This reconceptualization of writing was described in a...
Brain tumour post-treatment imaging and treatment-related complications

The imaging of primary and metastatic brain tumours is very complex and relies heavily on advanced magnetic resonance imaging (MRI). Utilisation of these advanced imaging techniques is essential in helping clinicians determine tumour response after initiation of treatment. Many options are currently available to treat brain tumours, and each can significantly alter the brain tumour appearance on post-treatment imaging. In addition, there are several common and uncommon treatment-related complications that are important to identify on standard post-treatment imaging. This article provides a review of the various post-treatment-related imaging appearances of brain neoplasms, including a discussion of advanced MR imaging techniques available and treatment response criteria most commonly used in clinical practice. This article also provides a review of the multitude of treatment-related complications that can be identified on routine post-treatment imaging, with an emphasis on radiation-induced, chemotherapy-induced, and post-surgical entities. Although radiological evaluation of brain tumours after treatment can be quite challenging, knowledge of the various imaging techniques available can help the radiologist distinguish treatment response from tumour progression and has the potential to save patients from inappropriate alterations in treatment. In addition, knowledge of common post-treatment-related complications that can be identified on imaging can help the radiologist play a key role in preventing significant patient morbidity/mortality. • Contrast enhancement does not reliably define tumour extent in many low-grade or infiltrative gliomas. • Focal regions of elevated cerebral blood volume (rCBV) on dynamic susceptibility contrast (DSC) perfusion-weighted imaging are suggestive of tumour growth/recurrence. • Brain tumour treatment response criteria rely on both imaging and clinical parameters. • Chemotherapeutic agents can potentiate many forms of radiation-induced injury. • Ipilimumab-induced hypophysitis results in transient diffuse enlargement of the pituitary gland.
Association between habitual physical activity on episodic memory strategy use and memory controllability.

Background: The primary objective of this study was to evaluate the association between habitual physical activity engagement and perceived controllability of memory function. Secondary objectives included the evaluation of physical activity on memory strategy use, and whether the latter mediates the relationship between physical activity on memory controllability. Methods: Two-hundred and nine young adults (Mage=25 y) completed a brief survey evaluating physical activity (Physical Activity Vital Signs Questionnaire), memory strategy use (Memory Functioning Questionnaire), and memory controllability (Memory Controllability Inventory). Results: Physical activity was not associated with memory strategy use (β=0.68; 95% CI: -1.25,2.62; P=0.48), nor was memory strategy use associated with memory controllability. Physical activity was consistently associated with various attributes of memory controllability, including Present Ability (β=1.10; 95% CI: 0.07, 2.12; P=0.03), Potential Improvement (β=0.84; 95% CI:0.05, 1.63; P=0.03), Effort Utility (β=0.87; 95% CI: 0.11, 1.61; P=0.02), Inevitable Decrement (β=-1.19; 95% CI: -2.19, -0.19; P=0.02) and Alzheimer’s likelihood (β=-1.21; 95% CI: -2.29,-0.12; P=0.02). Conclusion: Physical activity is consistently associated with greater perceptions of memory controllability. Future longitudinal and experimental work on this topic is warranted to evaluate if physical activity can foster an individual’s ability to modify their behavior and cognitions to enhance and preserve memory function.
New approach to adjuvant therapy in high-risk melanoma patients.

e13129 Background: Cutaneous melanoma is relatively chemoresistant, but it is an immunogenic tumor. However, it is very heterogenetic. As a result, the present adjuvant therapy has been met with li...
Love as Dependency, Attachment, Trust, and Honesty

This chapter discusses the experience and expression of dependency, attachment, trust, and honesty in love. In positive ways, these experiences create the feelings of security and comfort, yet, in case of violation of expectations makes people suffering. One topic, which is not covered in this chapter, is the experience of tolerance and acceptance. Although it seems the key for endurance of love relationship, yet cross-cultural studies have not investigated this topic so far.
Remarkable self-degradation of Cu/SAPO-34 selective catalytic reduction catalysts during storage at ambient conditions

Abstract A model Cu/SAPO-34 SCR catalyst with all Cu species maintained as isolated Cu(II) ions is synthesized. Following lengthy storage on the shelf under ambient conditions, this catalyst completely and irreversibly deactivates upon any heat treatments above ∼100 °C. Via detailed characterizations with surface area/pore volume analysis, XRD, H2-TPR, and 27Al, 29Si and 31P solid-state NMR, as well as continuous wave and pulsed EPR studies, it is concluded that over the course of storage, the SCR active sites [Cu(OH)]+ and Bronsted acid sites ≡Si-O(H)-Al≡ are attacked by H2O molecules trapped in the SAPO-34 framework pores, and undergo hydrolysis to form copper hydroxide and terminal Al sites. Upon thermal treatment, these species interact with each other to form copper-aluminate-like species, leading to irreversible deactivation of this catalyst. This deactivation mechanism does not require or necessarily lead to extensive degradation (i.e., crystallinity loss) of the SAPO-34 support.
Use of alternative water sources in irrigation: potential scales, costs, and environmental impacts in California

Abstract Under the risk of drought, unreliable water supplies, and growing water demand, there is a growing need worldwide to explore alternative water sources to meet the demand for irrigation in agriculture and other outdoor activities. This paper estimates stocks, production capacities, economic costs, energy implications, and greenhouse gas (GHG) emissions associated with recycled water, desalinated brackish and seawater, and stormwater in California, the largest US state and the most significant fresh and processed food producer. The combined recycled water and stormwater supply could increase the share of alternative water use in urban land irrigation (parks and golf courses) from the current rate of 4.6% to 48% and in agriculture from 0.82% to 5.4% while increasing annual water costs by $900 million (1.8% of California’s annual agricultural revenue) and energy use by 710 GWh (0.28% of California’s annual electricity consumption). The annual supply of alternative water greatly exceeds the amount of water currently used in the food processing industry. In case studies of high-value agricultural produce, conventional water use was found to contribute approximately 17%, 12%, 4.1%, and 1.7% to the total GHG emissions of avocados, lemons, celery, and strawberries, respectively. However, materials (mostly packaging) contribute 46%, 26%, 47%, and 66%, and diesel use on farms 18%, 28%, and 14% for lemons, celery, and strawberries, respectively (data for avocados were not available). Switching to recycled water or stormwater would increase the total GHG emissions of one serving size of packaged strawberries, celery, lemons, and avocados by 3.0%, 7.8%, 11%, and 27%, respectively, desalinated brackish water by 23%, 58%, 150%, and 210%, and desalinated seawater by 35%, 88%, 230%, and 320%. Though switching to alternative water will increase costs, energy demand, and GHG emissions, they could be offset by turning to less environmentally damaging materials in agricultural production and sales (especially packaging).
Social Media Consumption Among Kenyans: Trends and Practices

A Journal article by Dr. Patrick Kanyi Wamuyu, an Associate Professor of Information Technology at the School of Science and Technology in USIU- Africa Full Article: https://doi.org/10.4018/978-1-7998-4718-2.ch006
Citizens of Beauty: Drawing Democratic Dreams in Republican China

In Citizens of Beauty: Drawing Democratic Dreams in Republican China, Louise Edwards draws a captivating picture of personal modernization as she sheds light on the role of visual media in China’s ...
The Matador's Cape: America's Reckless Response to Terror

Introduction Part I. The Terrorist Enigma: 1. Did religious extremism cause 9/11? Part II: Show of Force: 2. Why military superiority breeds illusions 3. How the war was lost 4. Radicals trapped in the past 5. A self-inflicted wound Part III. False Templates: 6. Searching for a new enemy after the Cold War 7. Humanitarianism with teeth 8. The war of the liberals 9. The neoconservative intifada Part IV. Waiving the Rules: 10. Liberalism strangled by war 11. The unilateralist curse 12. Battling lawlessness with lawlessness 13: The infallibility trap Conclusion.
Religion and Psychology

The relationship between religion and psychology has often been contentious, with religious rejection of secular psychology on the one hand, and psychological rejection of religious experience on the other hand. Religion and psychology have often been in competition over their shared interest in providing an understanding of what it means to be human. As a matter of presupposition, both psychology and religion require some prior philosophical anthropology, and it is at this most basic level that the tensions between the two arise. In the West, the clash between religion and psychology reflects the contradictory Western conceptual traditions of Judeo-Christian subjective engagement versus Greek objective detachment. Keywords: religion; theology; metaphysics; philosophical anthropology
A method for radiologic detection of fetal maturity.

Abstract A posteroanterior x-ray of pregnant women at 34 to 40 weeks' gestation will regularly visualize the fetal lumbar vertebrae. The measured lumbar vertebral length yields a mean figure (± 5 cm.) for total length; reference to an intrauterine growth chart will yield an approximation of fetal maturation. In our study, a fetal lumbar vertebral length of 52 mm. or more signified that 95 per cent of the group weighed more than 2,500 grams and measured 49 cm. or more in total length.
Transcription inhibition by Actinomycin D as a mechanism-based approach to treatment of Bcr-Abl-positive chronic myelogenous leukemia

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA 3211 The transcription inhibitor flavopiridol reduces the Bcr-Abl mRNA level and induces cell death in the human Bcr-Abl positive chronic myelogenous leukemia (CML) cell line, K562, and in murine Ba/F3 cells made dependent on its expression. This action of flavopiridol is synergistic with the Bcr-Abl kinase inhibitor imatinib. These results support the sequential blockade hypothesis, which proposes that decreasing the cellular levels of oncogene proteins, that are required for tumor cell survival and proliferation, by inhibitors of transcription and/or translation would augment the action of specific kinase inhibitors (Cancer Res., 66:10959, 2006). This strategy would be most effective in tumor cells that are addicted to the expression of an oncogene, and for oncogenes with short intrinsic half-lives in their mRNAs and proteins. The Bcr-Abl addicted CML is an ideal model system to evaluate this strategy. Here, as an extension of this sequential blockade strategy, we studied another transcription inhibitor, actinomycin D (ActD), a polypeptide antibiotic that is useful for the treatment of sarcomas, Wilms’ tumor, testicular cancer and choriocarcinoma. The action of ActD as a transcription inhibitor was confirmed in the K562 cells. ActD inhibited RNA synthesis as measured by [3H]uridine incorporation with an IC50 of 60 ng/ml after 3 hr of incubation. This was associated with a decrease in the transcript level of Bcr-Abl, measured by real-time quantitative PCR. Consequently, the Bcr-Abl protein level also decreased. As K562 cells are critically dependent on the continuous expression of Bcr-Abl for survival, decreasing the expression of Bcr-Abl induced cell death in the cells. This was demonstrated as induction of PARP cleavage visualized by immunoblots, inhibition of cell growth and clonogenicity. ActD also reduced the transcript and protein levels of c-Myc and Mcl-1, other oncoproteins with short turn over rates. However, siRNA knockdown procedures suggested that c-Myc levels did not affect K562 cell viability. Further, the Ba/F3 cells expressing either the wild-type p210 Bcr-Abl, or the imatinib resistant T315I or E255K mutations of Bcr-Abl were equally sensitive to ActD in clonogenic assays, with IC50 values of 1-2 ng/ml, indicting lack of cross resistance. Thus, these data support the use of ActD for treatment of oncogene-addicted tumors such as CML, both to complement the activities of Bcr-Abl kinase-targeted inhibitors such as imatinib, desatinib, and nilotinib, and to overcome resistance to these kinase inhibitors due to mutations in the Bcr-Abl kinase domain. Other short-lived oncogenic kinases that sustain the tumor phenotype could also be targeted by ActD, including the activated c-Kit in gastrointestinal stromal tumors and platelet-derived growth factor receptor in myeloproliferative disorders.
Prediction and adaptation in PID controller design

Gives an interpretation of minimum variance adaptive control as high gain proportional feedback combined with output predictions. It is argued that a more general class of systems may be controlled if the feedback gain is reduced, and methods for reducing the gain and analyzing the resulting controllers are described herein. As a special case the authors obtain a new formulation of adaptive PID control. Frequency domain analysis is emphasized in both control design and identification. >
Micromotion between the tibial tray and the polyethylene insert

This study quantifies the micromotion at the polyethylene insert tibial tray interface of four different designs of total knee components as a first step towards determining the role this interface plays in the generation of PE wear debris and subsequent failure of the implant. Evidence of backsurface wear was visible by eye on most PE inserts and easily found by profilometry on all inserts directly below the point of loading on the proximal surface. Design parameters were shown to have a significant effect on micromotion. The consistency of the data for each design testifies to the quality control efforts of the manufacturers. The uniformity of the data over a million cycles indicates that the differences seen are design-related and not evidence of changes due to loading. Prolonged testing is needed to assess the long term stability of insert fixation.
Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis

The success of Mycobacterium tuberculosis (Mtb) as a pathogen rests upon its ability to grow intracellularly in macrophages. Interferon-gamma (IFN-γ) is critical in host defense against Mtb and stimulates macrophage clearance of Mtb through an autophagy pathway. Here we show that the host protein ubiquilin 1 (UBQLN1) promotes IFN-γ-mediated autophagic clearance of Mtb. Ubiquilin family members have previously been shown to recognize proteins that aggregate in neurodegenerative disorders. We find that UBQLN1 can interact with Mtb surface proteins and associates with the bacilli in vitro. In IFN-γ activated macrophages, UBQLN1 co-localizes with Mtb and promotes the anti-mycobacterial activity of IFN-γ. The association of UBQLN1 with Mtb depends upon the secreted bacterial protein, EsxA, which is involved in permeabilizing host phagosomes. In autophagy-deficient macrophages, UBQLN1 accumulates around Mtb, consistent with the idea that it marks bacilli that traffic through the autophagy pathway. Moreover, UBQLN1 promotes ubiquitin, p62, and LC3 accumulation around Mtb, acting independently of the E3 ligase parkin. In summary, we propose a model in which UBQLN1 recognizes Mtb and in turn recruits the autophagy machinery thereby promoting intracellular control of Mtb. Thus, polymorphisms in ubiquilins, which are known to influence susceptibility to neurodegenerative illnesses, might also play a role in host defense against Mtb.
Minimizing femoral artery access complications during percutaneous coronary intervention: a comprehensive review.

Major bleeding complications after percutaneous coronary intervention (PCI) increase patient morbidity, prolong the hospital stay and costs, and are associated with reduced survival. Transfemoral access is still preferred at many centers given its familiarity and ease of use and is necessary in cases where large bore access is needed. Multimodality imaging with fluoroscopy, ultrasonography, and angiography can facilitate proper puncture of the common femoral artery. A proper technique (which includes femoral artery puncture and vascular access site closure) associated with adequate pharmacotherapy (both during PCI and peri-procedural, for the treatment of the underlying coronary artery disease) has been shown to reduce the risk of bleeding and vascular complications associated with femoral artery access. Avoiding the use of arterial sheaths >6 French may further reduce the risk of bleeding. Data with vascular closure devices as a bleeding avoidance strategy are evolving but when used appropriately may further reduce the risk of bleeding and vascular access complications, and in this regard are synergistic with bivalirudin. Randomized trials to confirm these recommendations are needed.
Conformer-specific photoisomerizaton of some 2-vinylbiphenyls

The ground-state conformations, spectroscopy, and photochemistry of 2-vinylbiphenyl and three of its vinyl-substituted derivatives have been investigated. The ground state exists as a mixture of syn and anti conformers in which the vinyl group is directed either toward or away from the unsubstituted phenyl ring. Both conformers are highly non-planar, having large phenyl–phenyl and phenyl–vinyl dihedral angles. The vinylbiphenyls are found to undergo conformer-specific photochemistry. The syn rotamers are non-fluorescent and undergo rapid and efficient cyclization to 8a,9-dihydrophenanthrene intermediates, which undergo rapid thermal sigmatropic rearrangements to yield 9,10-dihydrophenanthrenes. The intermediates have been generated at 77 K and detected by absorption spectroscopy. The singlet states of the anti rotamers are fluorescent, and undergo competing intersystem crossing and activated CC torsion. The torsional barriers are of the order of those for styrenes with similar vinyl substituents.
Effects of hydrocephalus and surgical decompression on cortical norepinephrine levels in neonatal cats.

Norepinephrine (NE) changes during hydrocephalus, and the effects of surgical decompression on these changes, were studied using a new model of neonatal hydrocephalus. Kittens 4 to 10 days old received intracisternal injections of a sterile solution of 25% kaolin. Controlkittens were injected similarly with sterile injectable saline. A subgroup of hydrocephalie animais was shunted using a cerebrospinal fluid lumbar-peritoneal catheter. Hydrocephalie animais were killed at approximately 25 days of age (16-21 days after kaolin injection). Surgical decompression was performed at 12, 16 and 17 days after kaolin injection; these animais were killed 30 days after the shunts were inserted. Control animais were killed at 29 and 53 days of age, to correlate with the ages of the hydrocephalie and shunted animais, respectively. Cortical samples equivalent to Brodmann’s areas 4, 22 and 17 were measured for NE using high-performance liquid chromatography. Hydrocephalus caused NE levels to decrease significantly in ail cortical areas. These alterations followed a rostrocaudal gradient in severity, with mean reductions of 65.8, 83.9, and 95.8% in areas 4, 22, and 17, respectively. Partial recovery oecurred in animais that received shunts 16 and 17 days after kaolin injection, such that NE reductions of 75.7, 56.2, and 81.6% were noted in areas 4, 22, and 17, respectively. Shunting at 12 days after kaolin injection produced complete recovery in areas 4 and 22, with only a 67.7% decrease in area 17.
Style, process, surface, context: Consulting as postmodern art

(1991). Style, process, surface, context: Consulting as postmodern art. Journal of Applied Communication Research: Vol. 19, The Agenda for Applied Communication Research, pp. 32-54.
Chaotic properties of the interacting-boson model: A discovery of a new regular region.

The chaotic properties of the interacting-boson model of nuclei are studied both classically and quantum mechanically. Classical phase diagrams are constructed in the general parameter space of the Hamiltonian known as Casten's triangle. They lead to a discovery of a nearly regular region which is probably related to an unknown approximate symmetry. Analysis of the quantum fluctuations of the spectrum and of the electromagnetic {ital B}({ital E}2) intensities confirms the classical results. The phase diagrams may be useful in identifying chaotic'' nuclei within the nuclear periodic table.
How many genes control body weight

To estimate the number of genes that influence body weight, we determined from records in the Mouse Genome Informatics database the phenotype of 1977 single-gene homozygous knockout (KO) strains of mice. Of the 899 records with viability or body weight information 542 (60%) were not viable (i.e., lethal or failed to thrive), 112 (12.5%) were lighter, 11 (1.2%) were heavier, and 234 (26%) had the same body weight relative to wild-type controls. There was no body weight information for 1078 entries. To parse these, we sampled by e-mail 105 investigators responsible for a KO strain. The results from this sample concurred with those from the database. Thus, 34% of viable KO mice have alterations in body weight. Extrapolating to a genome containing 30,624 genes, this implies there are ∼4190 genes that influence the body weight of the mouse. We suspect that even this large number may be an underestimate because some mice in the “no information” and “not viable” categories probably have altered body weights. Moreover, epistatic genes and obesity-promoting environments were not considered. These findings suggest a much greater fraction of the genome is involved in the control of body weight than is generally believed.
Risk factors associated with retinal hemorrhage in suspected abusive head trauma.

Purpose To determine risk factors associated with retinal hemorrhage (RH) in pediatric abusive head trauma (AHT) suspects. Methods Records of children aged 0-3 years hospitalized for suspected AHT from January 2007 to November 2011 were retrospectively reviewed in this case–control study. Children were classified into case and control groups based on RH presence. Medical history, presenting symptoms, reasons, and characteristics of injury were recorded. Logistic regression analysis was performed to identify risk factors. Results A total of 168 children (104 males) were included. Of these, 103 were classified as cases and 65 as controls. The mean age (with standard deviation) was 9.3 ± 8.3 months (range, 1 day-36 months). Of the 103 cases, 22 (21%) had subretinal hemorrhage, 9 (9%) had retinoschisis, and 1 (1%) had vitreous hemorrhage. Children presenting with lethargy or altered mental status ( P P P = 0.01546) were likely to have RH. All 23 children with skull or nonskull fracture without intracranial hemorrhage did not have RH ( P Conclusions Retinal hemorrhages were almost never found in the absence of intracranial hemorrhage and not found in the setting of fracture without intracranial hemorrhage.
Gamma Rays from the Inelastic Scattering of Neutrons in Aluminum, Magnesium, and Silver

Monoenergetic neutrons from the ${\mathrm{H}}^{2}(d, n){\mathrm{He}}^{3}$ reaction were used to bombard scatterers each in the form of a ring surrounding an unshielded NaI(Tl) gamma-ray spectrometer. The gamma-ray spectrum for each scatterer was obtained by subtracting the background counting rate from the counting rate with the scatterer in place. An analysis of the gamma-ray spectra yields discrete gamma-rays for each scatterer as follows: Al: 0.422*, 0.843, 0.988, 1.69, and 2.10 Mev; Mg: 0.438, 0.555, 0.688, 0.837, 1.00, 1.34, 1.91, 2.08*, and 2.44 Mev; Ag: 0.332*, 0.696, 0.795, 1.10, 1.99, 2.13*, 2.32, and 2.54* Mev. The starred gamma-ray energies denote those that have not been previously reported.
Clinical and virologic outcomes of hepatitis B and C viral coinfection after liver transplantation: Effect of viral hepatitis D

Abstract Hepatitis B (HBV) and C viral (HCV) dual-infection-associated liver disease is an uncommon indication for liver transplantation. The clinical and virologic outcomes in such patients have not been well studied. We retrospectively studied 13 patients with hepatitis B surface antigen (HBsAg) and antibody to HCV positivity who underwent orthotopic liver transplantation (OLT) and survived at least 30 days post-OLT Antibody to hepatitis delta virus (HDV) was negative in 8 patients (group I) and positive in 5 patients (group 11). Eleven of the 13 patients received standard hepatitis B immune prophylaxis, and they all remained HBsAg negative. All group I patients were HCV RNA positive after transplantation; in contrast, all group II patients were HCV RNA negative. Serum alanine aminotransferase levels were elevated in 88% (7 of 8) of the patients in group I compared with 20% (1 of 5 patients) in group II. None of the patients had graft loss from chronic rejection or recurrent hepatitis. Three patients had unsuspected hepatocellular carcinoma in the explant. We conclude that among liver transplant recipients with HBV and HCV coinfection, HDV infection is associated with the suppression of HCV replication and mild inflammatory activity after OLT
Domestic Service Revisited: Private Household Workers and Employers in a Shifting Economic Environment

In 1993, Nannygate, one of the many predicaments of the Clinton administration, highlighted a trend that has been many years in the making. Nannygate captured the nation's attention not only because it represented another example of the misuse of economic and political privilege but also because in recent years so many Americans have had first-hand experience employing private household workers.
Maintenance of a plant line containing an antisense gene and silencing of the target gene following sexual crosses.

Abstract Doubly transformed tobacco plants containing both sense and antisense chloramphenicol aceltyltransferase (CAT) genes and showing > 90% inhibition of CAT gene expression were previously produced. One such plant was back-crossed with untransformed tobacco, and progeny were selected in which the CAT and anti-CAT genes were segregated. Progency containing the CAT gene but lacking the antisense construct showed fully restored CAT activity whereas those containing only the antisense genes expressed no CAT activity. The latter were stably maintained through two generations. Recombination of the sense and antisense genes by sexual crossing resulted in efficient antisense RNA-mediated inactivation of the CAT gene.
A model of flapping motion in a plane jet

Abstract Flow visualization near the exit of a plane jet shows a small-amplitude disturbance whose wavelength is large relative to the jet shear layer thickness. Further downstream, in the transition region, concentrated regions of vorticity are observed which drive the flapping motion of the jet. These observations motivate an inviscid, two-dimensional model for the transitional region of the jet. Linear stability analysis of a piecewise-uniform shear layer model indicates that small-amplitude, long wavelength disturbances are unstable. Long wave theory shows that regions of high circulation convect downstream faster than regions of low circulation resulting in nonlinear steepening and that the rate of the steepening is directly proportional to the strength of the local shear. The long wave theory also shows that finite-amplitude sinuous disturbances at the jet centerline will grow linearly as they convect downstream. The results predict the steepening and growth of the jet centerline observed in the flow visualization.
T cell nature of exocytic and dermal lymphoid cells in atrophic parapsoriasis demonstrated by monoclonal Leu 1 and affinity isolated antibodies.

Tissues from atrophic large plaque parapsoriasis were examined using the indirect immunoperoxidase technique with a monoclonal T cell antibody as primary antibody, and affinity isolated peroxidase conjugated goat anti-mouse IgG as second stage antibody. The “T” cell nature of the dermal infiltrate and of single exocytic epidermal lymphocytes was demonstrated. The results obtained suggest that the method utilized will be useful for the demonstration of lymphoid cell subpopulations in a variety of cutaneous disorders in which a lymphocytic infiltrate forms a significant component of the histopathology observed. This technique also has the potential of providing information on the topographic localization and differentiation of lymphocytes within the various levels of the skin. Certain technical manipulations which may result in an improvement in the quality of results obtained are also discussed.
Discerning the latent structure of hypothetical psychosis proneness through admixture analysis

The application of psychometric procedures to a normal population sample to detect individuals with increased liability for schizophrenia is a useful methodological adjunct to the traditional genetic high-risk strategy. A necessary and reasonable step in the process of establishing the utility of a viable psychometric index of schizotypy is the formal investigation of the latent structure of psychometric values. The present study used admixture analysis to examine the distribution of scores on the Perceptual Aberration Scale (PAS), an objective measure of hypothetical psychosis-proneness, in a randomly ascertained sample of 18-year-old university students (n = 707). We applied parametric methods that assumed normally distributed component distributions; viewed in this context, our results are hypothesis-generating and not definitive confirmation of specific hypotheses. Within our methodological framework, the results provide strong evidence for the commingling of normal distributions, even after allowing for unequal variances across components and after removing skewness. The overall distribution of power-transformed data is consistent with the existence of three qualitatively distinct classes of PAS responders. We discuss our results in light of Meehl's model of schizotaxia, a "mixed model" of inheritance of liability to schizophrenia, and we review the methodological implications of our findings for future research.