Neural signaling opportunities for novel diagnostic approaches and therapies. Preface.

Part I: New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk:. 1. G Protein-coupled Receptor Structures, Molecular Associations, and Modes of Regulation: Laurence J. Miller. 2. Discovery of PACAP-regulated Genes through Microarray Analyses in Cell Culture and in Vivo: Lee E. Eiden, Babru Samal, Matthew J. Gerdin, Tomris Mustafa, and Nikolas Stroth. 3. Monitoring the State of Cholecystokinin Receptor Oligomerization after Ligand Binding Using Decay of Time-resolved Fluorescence Anisotropy: Kaleeckal G. Harikumar and Laurence J. Miller. 4. Role of Pituitary Adenylate Cyclase Activating Polypeptide in the Pancreatic Endocrine System: Bo Ahren. 5. PTHrP Regulates Gli Transcriptional Activation: Lessons Learned from Bone Development and Cartilage Neoplasia: Benjamin A. Alman and Jay S. Wunder. 6. Molecular Mechanisms of TRPV4-Mediated (neural) Signaling: Wolfgang Liedtke. 7. The Sall2 Transcription Is a Novel p75NTR Binding Protein That Promotes the Development and Function of Neurons: Roxana Pincheira and David B. Donner. Part II: Neuromediator Participation in Host Defense, Immunity, and Inflammation:. 8. Diverse Mechanisms and Consequences of Immunoadoption of Neuromediator Systems: Edward J. Goetzl, Robert C. Chan, Mahesh Yadav. 9. Substance P in Stress and Anxiety: NK1 Receptor Antagonism Interacts with Key Brain Areas of the Stress Circuitry: Karl Ebner, Patrik Muigg, Georg Singewald, Nicolas Singewald. 10. Mast Cells Stimulate Activated T Cells: Implications for Multiple Sclerosis: Theoharis C. Theoharides, Duraisamy Kempuraj, Taxiarchis Kourelis Akrivi Manola. 11. VIP-mediated Th17 Differentiation: An Expanding Spectrum of VIP Effects in Immunity and Autoimmunity: Mahesh Yadav and Edward J. Goetzl. 12. Neurokinin-1 Receptor Expression and Function Macrophages and Brain- Role in HIV Neuropathogenesis - (Perspective): Steven D. Douglas, Jian-Ping Lai, Florin Tuluc, Lynnae Schwartz, and Laurie E. Kilpatrick. Part III: Neuromediators in Diseases:. 13. Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease: Mark P. Mattson. 14. Diversity of Neuropathogenic Mechanisms and Implications of Neuromediation of Diseases: Susan E Leeman. 15. Inhibitory Effects of a Neurokinin-1 Receptor Antagonist on Postoperative Peritoneal Adhesion Formation: Karen L. Reed, Arthur F. Stucchi, Susan E. Leeman, and James M. Becker. 16. Neuropeptides, Mesenteric Fat, and Intestinal Inflammation: Iordanes Karagiannides and Charalabos Pothoulakis. 17. Gastrin-Releasing Peptide, Immune Responses, and Lung Disease: Simone Degan, Giselle Y. Lopez, and Mary E. Sunday. 18. The VIP Gene Is a Key Modulator of Pulmonary Vascular Remodeling and Inflammation: Sami I. Said. Part IV: Neuromediators in Prenatal Development and Stress:. 19. Prenatal Alcohol Exposure Increases Vulnerability to Stress and Anxiety-like Disorders in Adulthood: Kim G.C. Hellemans, Pamela Verma, Esther Yoon, Wayne Yu, and Joanne Weinberg. 20. Role of Various Neurotransmitters in Mediating the Long-term Endocrine Consequences of Prenatal Alcohol Exposure: Soon Lee, Irene Choi, Sang Kang and Catherine Rivier. 21. Perinatal Maternal Fat Intake Affects Metabolism and Hippocampal Function in the Offspring: A Potential Role for Leptin: Claire-Dominique Walker, Lindsay Naef, Esterina d'Asti, Hong Long, Zhifang Xu, Alain Moreau, and Bouziane Azeddine. Part V: Diagnostic and Therapeutic Strategies for Neuromediators in Diseases:. 22. Informed Development of Drugs Acting at Family B G Protein-coupled Receptors: Laurence J. Miller. 23. Experimental Therapeutic Strategies for Severe Sepsis: Mediators and Mechanisms: William R. Parrish, Margot Gallowitsch-Puerta, Christopher J. Czura, and Kevin J. Tracey. 24. A New Hypothesis: Activation of the Pro-opiomelanocortin Gene with Ketoconazole as a Treatment for Parkinson's Disease: Alberto Halabe Bucay. 25. Opportunities and Challenges in the Discovery of New Central Nervous System Drugs: James E. Krause and Bertrand L. Chenard. 26. Molecular Imaging to Biomarker Development in Neuroscience: J. James Frost. 27. Studying the Brain Gut Axis with Pharmacological Imaging: Kirsten Tillisch, Zhuo Wang, Lisa Kilpatrick, Daniel P. Holschneider, and Emeran A. Mayer. Index of Contributors