cssi/SciSciGPT-SciSciNet huggingface dataset:
A Novel Organism Lactobacillus wasatchensis: Growth, Detection, Gassing Defects in Cheese, Control Strategy and Future Research Opportunities: A Review

An obligate heterofermentative, Lactobacillus wasatchensis has been recently isolated from an aged Cheddar cheese produced in Logan, Utah. The potential of this organism in causing gassing defects in aged cheese has raised concern among cheese manufacturers. The recent attention on this organism is attributed to its economic impact due to low-quality cheese. This comprehensive review provides the details about Lb.wasatchensis characteristics, geographical distribution and effect of various physical and chemical factors such as heat treatment, carbohydrate utilization, pH, salt tolerance and growth temperature. Lb. wasatchensis utilize ribose as a primary source for its growth, however, it can slowly utilize galactose resulting in gas generation. The details of testing methods along with suggestions for future research on improving these techniques using a phage as a selective medium are provided in this review. Recent research developments for controlling the growth of Lb. wasatchensis, as well as potential research opportunities are summarized in this review.
Impact of COVID-19 on Omnichannel Retail: Drivers of Online Sales during Pandemic

Measures to limit the spread of COVID-19 have impacted retailers greatly. While many retailers temporarily closed their physical stores – due to stay-at-home orders and mandatory non-essential business closures – some online-only retailers witnessed higher sales. An omnichannel retailer is exposed to both of these effects, and in addition, may be affected by the channel-shift of its existing customers from stores to online. Using a proprietary dataset, we provide the first empirical evidence of the impact of COVID-19, particularly government interventions, on an omnichannel retailer’s performance. We find that online sales increase, driven both by the acquisition of new customers and by online purchases from existing customers who previously purchased items primarily at physical stores. In contrast to the latter effect, online purchases from existing customers who used to purchase primarily online did not change. The retailer also benefits significantly from introducing an essential product (e.g., hand sanitizer) into its portfolio, even though it is not part of its core assortment: the essential product helps the retailer acquire new customers and induces previously offline-leaning customers to shop online. Our study reiterates how being omnichannel can help the retailer adapt during a pandemic, and offers useful tactical suggestions for managers; for example, targeted advertising of the retailer’s online channel could be combined with new customer promotions in high-income areas.
Electroless Copper Plating on Different Types of Ceramic Particles and Its Effects on Mechanical Properties of Particulate Reinforced Iron Matrix Composites

Electroless Cu plating process has been studied in order to coat three kind of ceramic particles of different size. It is found that the amount of complexing agent addition in the plating bath should be adjusted corresponding to the size of the coated particles to obtain coatings with acceptable quality.However, all the three kind of ceramic particles show more or less the same behavior during plating. Mechanical properties of the Si Cp/Fe、Ti Np/Fe and Ti Cp/Fe composites containing reinforcing particulates with and without Cu coating respectively were measured comparatively. Results show that the mechanical properties of all the three composites with Cu coated reinforcing particles are superior significantly to their counterparts. However the highest enhancement of tensile strength induced by Cu coated particles was observed for the Ti Np/Fe composite, but not for the Si Cp/Fe composite, which showed the highest tensile strength among the three composites with raw ceramic particles without Cu-coating. It is clear that the defects at the interfaces of particles and matrix should be a determining factor affecting the tensile strength of the composite. Similarly, the larger content of particles with Cu coating in the composite is, the higher enhancement in mechanical properties may be expected. Moreover, microstructure analysis also indicates that the copper coating on particles could effectively avoid the direct contact of particles and reduce defects formed at the interfaces between the particles and matrix.
College-based social and situational predictors of real-time prescription drug misuse in daily life

Abstract Background This study examined social and situational context predictors of prescription drug misuse among college-students at a large public university in the Midwest. Social and situational context predictors considered were hour of the day, weekend vs weekday, whether participants were at home or another place, and who they were with during instances of misuse. Salient social events, including home football games, city-regulated parties, and the 2019 Midwest polar vortex were also recorded. Method Using ecological momentary assessment methodology, 297 students completed momentary reports for 28 days. Participants indicated whether they had misused prescription medication (sedatives or sleeping pills, tranquilizers or anxiety medications, stimulants, and pain relievers) and reported on their social and situational context in the moment of misuse. Results Multilevel modeling indicated that participants were more likely to misuse prescription medication earlier in the day vs. the evening, on weekdays vs. weekends, when at home vs. not at home, and while alone vs. with others. Conclusions This study provides descriptive information on the social context in which prescription drug misuse is most likely to occur among college students. Our findings suggest that social and situational contexts of prescription drug misuse likely differ as compared to other substances (e.g., alcohol) among college students. Further research aimed at identifying momentary predictors of prescription drug misuse in this population is warranted.
Towards 6G and Beyond: Smarten Everything with Metamorphic Surfaces

6G is on the horizon. A key paradigm being proposed for 6G involves a shift from device-centric to user-centric services, i.e., multiple devices collaborate to serve user demands. This paradigm shift and the potential applications require handling wireless signals from multiple sources collectively in a 3D space and potentially at close proximity to the end user. Conventional approaches of optimizing individual communication endpoints are ill-suited to collaborative 3D signal shaping. Recent smart surface proposals to program the radio environments appear a better fit, but existing designs implicitly require planar, rigid substrates. Optimizing 3D coverage would require very large surface implementations and incur many scalability and deployment challenges. In this paper, therefore, we propose a notion of metamorphic smart surfaces, i.e., shape-changing smart surfaces to cater to complex 3D propagation environments. Based on early explorations with HFSS simulations and two simple prototypes, we discuss the pros and cons of metamorphic surfaces and potential future directions.
The founding of the Fed and the behavior of interest rates: What can be learned from small samples?

Abstract We take issue with Angelini's (1994) claim that the founding of the Federal Reserve was not responsible for a change in the stochastic process followed by short-term interest rates. We argue that Angelini's failure to reject the null hypothesis of no regime change around the date of the founding of the Fed is due to the low power of his test.
Predicting Proficiency on Statewide Assessments: A Comparison of Curriculum-Based Measures in Middle School

ABSTRACTA key tool in multitiered systems of support is the use of curriculum-based measures to predict which students are at risk for academic failure. However, there are few studies that examine which measures are most suitable for students in middle school. The authors examine the reliability of predicting outcomes on state assessments for 3 commonly used curriculum-based measures at the middle school level. Data were collected from a middle school in the Midwest that regularly administers 3 different curriculum-based measures. Reading Curriculum-Based Measure (R-CBM), Maze, and Multiple-Choice Reading Comprehension (MCRC) were given to students in Grades 7 (n = 238) and 8 (n = 256). Logistic regression was used to examine each measure in predicting outcomes on the Michigan Education Assessment Program Reading assessment. Results indicated that MCRC more accurately predicted outcomes than R-CBM or maze (Grade 7 eβ = 1.75, Grade 8 eβ = 1.68). Limitations and recommendations for future research are discu...
Interactions between dissociated rat sympathetic neurons and skeletal muscle cells developing in cell culture. I. Cholinergic transmission.

Abstract Sympathetic neurons, dissociated from superior cervical ganglia of newborn rats, and skeletal muscle cells were grown together in mass cultures containing many neurons (ca. 1000–3000) and myotubes, and in microcultures containing only one to three neurons and one or a few myotubes. When these neurons grow under the influence of certain nonneuronal cells many of them acquire cholinergic functions; in the absence of this influence they remain adrenergic. In the present study, the influence of the skeletal muscle cells was so effective that under certain conditions more than 75% of the neurons expressed cholinergic function as judged by their ability to form excitatory cholinergic synapses with myotubes (from rat and chick) and with each other. Stimulation of single neurons often gave rise in the myotubes to simple (direct) postsynaptic potentials (ejp's) and/or complex responses comprising a burst of ejp's that evoked one or more spikes; it appeared that these complex responses involved the activation of interneuronal pathways. In microcultures, a single neuron often made cholinergic synapses with itself (“autapse”) and/or with another neuron as well as with one or more myotubes. The nicotinic blocking agents, tubocurare ( d TC), α-bungarotoxin (α-BuTx), and hexamethonium (C 6 ), attenuated or abolished the ejp's at moderate concentrations; the muscarinic blocker, atropine, was effective only at high concentrations. At several neuron-myotube junctions, the acetylcholine (ACh) receptors had d TC sensitivity similar to adult extrajunctional receptors; however, when different junctions were pooled the average d TC sensitivity was intermediate between that of adult end plate and extrajunctional receptors. The junctional C 6 sensitivity was much higher than expected from the action of the drug at the adult mammalian end plate. As in other studies, chemical transmission from neuron to neuron was also nicotinic cholinergic, but the nicotinic receptors on the myotubes were pharmacologically distinct from those on the neurons.
Disability and Justice

Historically, philosophers have had little to say about justice and disability. However, in recent years and in response to disability rights movements, philosophers have started to consider the claims to justice of persons with mental and physical impairments. Importantly, some have charged that without extensive revision, social contract accounts of justice – which enjoy immense popularity among political philosophers – cannot address the needs and interests of persons with disabilities. In this article, I explain why social contract accounts are thought to flounder when it comes to justice for persons with disabilities. Then I assess the merits of recent attempts to construct theories of justice inclusive of persons with disabilities. In particular, I consider Nussbaum’s capabilities approach, Kittay’s justice as caring, and various restatements of the social contract.
Does vaccine dose predict response to the monovalent pandemic H1N1 influenza a vaccine in children with acute lymphoblastic leukemia? A single-centre study.

Background Vaccination against influenza is an important strategy in preventing severe infection among children with acute lymphoblastic leukemia (ALL). Successful vaccination depends on both vaccine and host-related factors. We conducted a study on factors predicting the immunogenicity of the monovalent pandemic H1N1 (pH1N1) influenza A vaccine in children with ALL. Methods Children with ALL in our hospital were recruited and received two doses of the inactivated split-virion AS03-adjuvanted vaccine. The serological response was measured before each vaccine dose (Day 0 and 28) and 3 months after the second dose. Antibody titres were measured using a hemagglutination–inhibition assay. Seroconversion was defined as a ≥fourfold increase in antibody titre and a post-vaccination titre ≥1:40. Results Pre and post-vaccination titres were available from 45 children with ALL after one dose of the vaccine and 39 children after two doses. The seroconversion rate was 11.1% after one dose and 25.6% after the second dose. Univariate analysis demonstrated a significantly higher (P = 0.01) seroconversion rate among children who received the adult dose (0.5 ml) of the vaccine and a trend towards increased seroconversion (P = 0.07) by multivariate analysis. Factors including age, gender, lymphocyte count, treatment phase and regimen did not significantly affect the seroconversion rate. Children who received the adult dose demonstrated a significantly greater magnitude of serological response after both one dose (P = 0.04) and two doses (P = 0.001). Conclusions These data suggest that the immunogenicity of the pH1N1 vaccine among children with ALL is improved by repeated and adult doses of the vaccine. Pediatr Blood Cancer 2013;60:1656–1661. © 2013 Wiley Periodicals, Inc.
Linear and Nonlinear Binary Kernels of Polar Codes of Small Dimensions With Maximum Exponents

Polar codes are constructed based on kernels with polarizing properties. The performance of a polar code is characterized asymptotically in terms of the exponent of its kernel. The pioneering work of Arikan on polar codes is based on a linear kernel of dimension two and exponent 0.5. In this paper, constructions of linear and nonlinear binary kernels of dimensions up to 16 are presented. The kernels are obtained using computer search or by shortening longer kernels obtained by computer search and a computer program is used to determine their exponents. It is proved that the constructed kernels have maximum exponents except in the case of nonlinear kernels of dimension 12 where it is demonstrated that the maximum exponent either equals that of the presented construction or assumes another specified value. The results show that the minimum dimension for which there exists a linear kernel with exponent greater than 0.5, i.e., exceeds the exponent of the linear kernel proposed by Arikan, is 15, while this minimum dimension is 14 for nonlinear kernels. Furthermore, it is shown that there is a linear kernel with maximum exponent up to dimension 11. For dimensions 13, 14, 15, and 16, there are nonlinear kernels with exponents larger than any of that of a linear kernel. The kernels of these dimensions that have maximum exponent, although nonlinear over $ \textrm {GF}(2)$ , are $\mathbb {Z}_{4}$ -linear or $\mathbb {Z}_{2}\mathbb {Z}_{4}$ -linear.
Spectroscopy of Young Brown Dwarfs and Isolated Planetary Mass Objects

This paper presents an overview of the spectroscopic properties of substellar objects found in young (age between 1 and 20 Myr) open clusters and stellar associations. An updated status of spectral classification and temperature calibrations is given. A reddening-independent spectral index is provided for L-type dwarfs. The spectral types that separate stars from brown dwarfs, and brown dwarfs from planetary mass bodies, are discussed. The behaviour of gravity sensitive features, which potentially can play a key role in an age scale for star forming regions and young open clusters, is described. Current one-dimensional schemes for spectral classification of ultracool dwarfs should be taken with caution. The observed emission lines in young brown dwarfs and isolated superplanets are discussed. A possible selection bias against finding accreting brown dwarfs and isolated superplanets (substellar equivalents of the classical T Tauri stars) is identified. Finally, we comment on the possibility of using deuterium burning to provide an age scale for young associations and clusters.
Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer.

Purpose: Induction chemotherapy with carboplatin and paclitaxel followed by concomitant TFHX (paclitaxel, infusional 5-fluorouracil, hydroxyurea, and twice-daily radiation therapy administered every other week) has resulted in 70% 3-year survival in stage IV patients. Locoregional and distant control rates were 94 and 93%, respectively. In an attempt to decrease toxicity without compromising local control, a second cohort of patients was treated with a lower dose of radiation to sites of potential microscopic disease. Experimental Design: Sixty-four patients were entered on study. Patients received six weekly doses of carboplatin (area under the curve 2) and paclitaxel (135 mg/m 2 ) followed by five cycles of TFHX. The radiation dose to gross disease was 75 Gy as in the previous trial. The radiation dose to high-risk microscopic disease was reduced from 60 to 54 Gy, and the dose to low-risk microscopic disease was reduced from 45 to 39 Gy. Results: Ninety-seven percent of patients had stage IV disease. The response rate to induction chemotherapy was 82% with a complete response rate of 42%. At the completion of therapy the clinical complete response rate rose to 100% with a median follow-up of 29 months. The actuarial 2 and 3-year survival was 77 and 70%, respectively. Five patients developed progressive disease for an overall 3-year progression-free survival of 90%. Two patients failed in locoregional sites alone, resulting in a 3-year locoregional control of 97%. The 3-year systemic control was 95%. Four patients were completely feeding tube dependent at the time of analysis. Only 1 of these patients had normal swallowing function before treatment. Conclusions: In this second trial, induction chemotherapy with carboplatin and paclitaxel followed by TFHX chemoradiotherapy results in high survival and progression-free survival. The reduction in radiation dose did not compromise survival or disease control compared with our prior study using higher radiation doses. Data continues to support definitive evaluation of this approach.
Nest architecture shapes the collective behaviour of harvester ants

Structures influence how individuals interact and, therefore, shape the collective behaviours that emerge from these interactions. Here I show that the structure of a nest influences the collective behaviour of harvester ant colonies. Using network analysis, I quantify nest architecture and find that as chamber connectivity and redundancy of connections among chambers increase, so does a colony's speed of recruitment to food. Interestingly, the volume of the chambers did not influence speed of recruitment, suggesting that the spatial organization of a nest has a greater impact on collective behaviour than the number of workers it can hold. Thus, by changing spatial constraints on social interactions organisms can modify their behaviour and impact their fitness.
Spectral Effects of Three Types of White Light-emitting Diodes on Plant Growth and Development: Absolute versus Relative Amounts of Blue Light

Light-emitting diodes (LEDs) are a rapidly developing technology for plant growthlighting andhavebecome apowerful toolfor understandingthe spectraleffects of light on plants. Several studies have shown that some blue light is necessary for normal growth and development, but the effects of blue light appear to be species-dependent and may interact with other wavelengths of light as well as photosynthetic photon flux (PPF). We report the photobiological effects of three types of white LEDs (warm, neutral, and cool, with 11%, 19%, and 28% blue light, respectively) on the growth and development of radish,soybean,andwheat.AllspeciesweregrownattwoPPFs(200and500 mmol·m L2 ·s L1 ) under each LED type, which facilitated testing the effect of absolute (mmol photons per m L2 ·s L1 ) and relative (percent of total PPF) blue light on plant development. Root and shoot environmental conditions other than light quality were uniformly maintained among six chambers (three lamp types 3 two PPFs). All LEDs had similar phytochrome photoequilibria and red:far red ratios. Blue light did not affect total dry weight (DW) in any species but significantly altered plant development. Overall, the low blue light from warm white LEDs increased stem elongation and leaf expansion, whereas the high blue light from cool white LEDs resulted in more compact plants. For radish and soybean, absolute blue light was a better predictor of stem elongation than relative blue light, but relative blue light better predicted leaf area. Absolute blue light better predicted the percent leaf DW in radish and soybean and percent tiller DW in wheat. The largest percentage differences among light sources occurred in low light (200 mmol·m L2 ·s L1 ). These results confirm and extend the results of otherstudies indicating that light quantity and quality interact to determine plant morphology. The optimal amount of blue light likely changes with plant age because plant communities balance the need for rapid leaf expansion, which is necessary to maximize radiation capture, with prevention of excessive stem elongation. A thorough understanding of this interaction is essential to the development of light sources for optimal plant growth and development.
Development and Testing of an Advanced Neutron-Absorbing Gadolinium Alloy for Spent Nuclear Fuel Storage

The U.S. Department of Energy requires nuclear criticality control measures for storage of its highly enriched spent nuclear fuel. A new alloy based on the Ni-Cr-Mo alloy system with a gadolinium addition has been developed. Gadolinium has been chosen as the neutron absorption alloying element because of its high thermal neutron absorption cross section. The metallurgical development, mechanical and physical properties, thermal neutron absorption properties, and accelerated corrosion-testing performance of this Ni-Cr-Mo-Gd alloy is described. A brief comparison is also included of the corrosion performance of this alloy as compared to borated stainless steel, which is commonly used as a neutron-absorbing, structural alloy.
Agriculture Intensification and Ecologically Sustainable Land Use in Niger: A Case Study of Evolution of Intensive Systems with Supplementary Irrigation

ABSTRACT In Niger, a breakdown of the bush-fallow system, low crop yields and reduced availability of communal land have resulted from increasing population pressure. Agricultural intensification is critical to the future development of the region. Intensification of agricultural production in Niger must include adoption of sustainable yield increasing technologies, fertilizer use, supplementary irrigation and/or water conservation, high yielding cultivars and improved crop management practices. On-farm constraints analysis of crop productivity and technologies assessment was carried out in two irrigated perimeters: the Konni surface irrigation and the Djirataoua deep well system where supplemental irrigation is provided to rainy season crops in the event of long dry spells, and full irrigation is supplied to dry season crops. Konni is located in southern Niger, approximately 13°48'0′N, 5°15'0′E at approximately 257 m altitude; Djirataoua is located further east, approximately 13°20'0′N, 7°7'60′E at appro...
On classifying finite edge colored graphs with two transitive automorphism groups

This paper classifies all finite edge colored graphs with doubly transitive automorphism groups. This result generalizes the classification of doubly transitive balanced incomplete block designs with λ = 1 and doubly transitive one-factorizations of complete graphs. It also provides a classification of all doubly transitive symmetric association schemes.
Cultural-Specific Gender Ideology and Wife Abuse in Mexican-Descent Families

The present study, which was designed to improve understanding of the context, patterns, and meanings of violence against wives, uses a standpoint-based approach which incorporates a symbolic interactionist method and a feminist perspective to examine wife abuse in Mexican-descent families. Findings from the study indicate that wife abuse occurs in the complex context of economic hardship, changes in gender role expectations and performances, and husbands' attempt to maintain male dominance and control of the family. The control aspect of wife abuse was reflected in the patterns of violence used by husbands, the unequal power relationship between husbands and wives, and the differences between wives' and husbands' reactions to family conflicts. These findings suggest that efforts to stop wife abuse need to focus not only on increasing women's economic independence but also on eliminating culture-specific ideologies of male supremacy.
Insulin Acutely Inhibits Cultured Vascular Smooth Muscle Cell Contraction by a Nitric Oxide Synthase–Dependent Pathway

Insulin acutely decreases contractile agonist-induced Ca2+ influx and contraction in endothelium-free cultured vascular smooth muscle (VSM) cells, but the mechanism is not known. Since it has been reported that insulin-induced vasodilation in humans is linked to nitric oxide synthase activity, we wished to determine whether insulin inhibits Ca2+ influx and contraction of cultured vascular smooth muscle cells by a nitric oxide synthase-dependent pathway. Primary cultures of endothelial cell-free VSM cells from canine femoral artery were preincubated with and without 1 nmol/L insulin for 30 minutes, and the 5-minute production of cGMP was measured. Insulin alone did not affect cGMP production, but in the presence of 10(-5) mol/L serotonin insulin stimulated cGMP production by 60%. N(G)-monomethyl-L-arginine (0.1 mmol/L), an inhibitor of nitric oxide synthase, inhibited the conversion of arginine to citrulline by these cells, blocked insulin-stimulated cGMP production, and blocked the inhibition by insulin of 5-hydroxytryptamine (5-HT)-stimulated Mn+2 (a Ca2+ surrogate) influx and contraction. Insulin did not affect contraction of VSM cells grown under conditions designed to deplete the cells of tetrahydrobiopterin, an essential cofactor of nitric oxide synthase. These studies demonstrate that insulin acutely inhibits 5-HT-stimulated Ca2+ influx and contraction of endothelium-free cultured VSM cells by a nitric oxide synthase-dependent mechanism.
Amino-acid composition and cross-linking characteristics of collagen from intramuscular connective tissue of striated muscle (bos taurus

Abstract 1. 1. In samples representing 60–70 per cent of the total collagen from bovine semimembranosus muscle, the yields of salt- and acid-soluble collagen were 0.3 and 0.48 per cent, respectively. 2. 2. Collagen from muscle differed significantly from that of skin and tendon in solubility and distribution of cross-linked components. 3. 3. The component ratio of β 12 to β 11 was approximately 2: 1, indicating random crosslinking among the ai and α 2 -chains. 4. 4. The amino-acid composition of muscle collagen showed both similarities and differences when compared with either reticulin or skin and tendon collagens.
A Call for More Research on the Relationship Between Intelligence and Job Performance: Non-Task Performance, Non-Euro-American Contexts, and the Science-Practice Gap

Europe's Journal of Psychology, 2014, Vol. 10(1), 1–6, doi:10.5964/ejop.v10i1.757 Published (VoR): 2014-02-28. Handling Editor: Vlad Glaveanu, Aalborg University, Aalborg, Denmark *Corresponding author at: Department of Human Resource Management, Fox School of Business, Temple University, Philadelphia, PA 19122, United States. E-mail: insue.oh@temple.edu This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Higgs boson triplets with Mw=Mzcos θw☆

Abstract We construct a potential for Higgs doublets and triplets that preserves ϱ=M2w/M2wcos2θw=1, allowing the triplets to make the dominant contribution to W and Z boson masses.
NMR and AFMR modes in antiferromagnetic MnO

Abstract NMR modes in antiferromagnetic MnO interpreted in terms of a two sublattice model. Observation of AFMR mode at 27.6 GHz which correlates well with this interpretation.
The Merits of Unifying Terms: "Atrocity Crimes" and "Atrocity Law"

I am extremely grateful for the serious att ention that so many distinguished scholars have affor ded my article, ‘‘Genocide and Atrocity Crimes.’’1 I found their commentaries informative, insightful, and constructive.
945-121 The Paradoxical Hypertensive Systolic Blood Pressure Response to Dipyridamole Infusion—What are its Etiology and Implications?

To evaluate the etiology and implications of a paradoxical increase in systolic blood pressure (SBP) following dipyridamole infusion (0.56 mg/kg), we characterized the hemodynamic, symptomatic, electrocardiographic, and image findings in 341 consecutive patients undergoing clinically indicated stress myocardial perfusion studies from January to October, 1993. Most patients (n = 292) experienced a typical, generally mild, hypotensive SBP response (range 0–73 mmHg, average 22 mg Hg). Among 49 patients with a hypertensive SBP response (range 2–81 mmHg, average 27 mmHg), 18 were considered mild (0–19 mmHg), 22 were moderate (20–39 mmHg) and 9 were severe ( ≥ 40 mmHg). In those with a hypertensive compared to those with a typical SBP response, no significant difference was found in the prevalence of coronary vascular territories demonstrating total scintigraphic defects (0.88 vs 0.73) or reversible defects (0.51 vs 0.46). Heart rate increased directly in parallel with SBP (p l 0.05). Comparing hypertensive to typical responders, the presence of symptoms of headache or induced pain in the chest, abdomen, neck or jaw (20/49 vs 77/292, p l 0.05) were found more frequently. Significant ST segment depression was also more frequent in the hypertensive group (9/49 vs 19/292, p l 0.05). Finally, mild hypertensive responders demonstrated no difference in the nature or frequency of induced symptoms, electrocardiographic, or heart rate changes compared to those with the typical SBP response. These results suggest that a moderate or severe paradoxical hypertensive SBP response to dipyridamole infusion is not specific for induced ischemia but more often likely relates to induced pain symptoms, another cause of increased cathecholamine levels. This response does not appear to relate to the presence or extent of coronary artery disease or to the presence or nature of induced image abnormalities.
Analyzing pedagogical components using multiple regression

Purpose – The purpose of this paper is to show how one instructor used an integrated collection of technological and cognitive tools that consistently led to student success. Educators today struggle with the need to improve student success in a dynamic and increasingly technological world. Learners need to master more, more quickly and educators need to upgrade their skills to meet these needs. Design/methodology/approach – This vision-based research design focused on the goal that all students can succeed. The design took the non-traditional approach of separating pedagogical models that worked from those that did not. The objectives were achieved by successively improving the pedagogy. The components of the final model were evaluated using multiple regression to determine individual and summative effectiveness. Findings – The pedagogical model designed around the goals of allowing adequate time for scaffolded acquisition and increasing skill development demonstrated consistent student success in the A ...
Psychic loss in adult survivors of father-daughter incest.

Studies show that adult survivors of childhood incest comprise a significant percentage of female psychiatric patients. The varied and multidetermined presenting symptomatology of these patients frequently leads to misdiagnosis and treatment interventions that fail to address core issues of the incest experience. One such issue is the child's experience of the psychic loss of a physically present parent that is part of the emotional trauma of incest. The goal of this paper is to discuss psychic loss as a core element of the incest experience, particularly in father-daughter incest, and to describe the conditions of childhood mourning that inhibit successful resolution of this loss. Attention is addressed to the psychoanalytic understanding of mourning as a basis for interventions in the treatment of adult survivors. Language: en
Major histocompatibility complex class II and C4 alleles in Mexican Americans with systemic lupus erythematosus.

: Few data exist on associations of class II and class III alleles of the major histocompatibility complex (MHC) and susceptibility to systemic lupus erythematosus (SLE) in Mexican Americans, a group of predominantly mixed Spanish and Native American ancestry. Therefore, MHC class II alleles (HLA-DRB1, DQA1, DQB1, DPA1 and DPB1 alleles) and C4 allotypes were determined in 52 Mexican American SLE patients and 105 ethnic-matched controls. HLA-DRB1*0301 and C4A*Q0 were each increased in the SLE patients, especially HLA-DRB1*0301 in those with anti-Ro/SSA autoantibodies. C4A*Q0 was associated with HLA-DRB1*0301 only in a minority of patients and controls. Anti-U1-RNP antibodies were significantly associated with the presence of HLA-DQB1*0302, and the risk for the production of anti-Ro antibodies was heightened by the presence of at least three (out of four possible) DQA1 chains possessing a glutamine at position 34 and/or DQB1 chains a leucine at position 26 of their outermost domains. Thus the HLA class II and C4 null allele associations that have been noted in other ethnic groups are also found in Mexican Americans, suggesting shared susceptibility factors across ethnic lines in predisposition to SLE.
Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans.

Abstract Collagen genes col-6, col-7 (partial), col-8, col-14 and col-19 from the nematode Caenorhabditis elegans were sequenced, and compared to the previously sequenced genes col-1 and col-2. The genes are between 1.0 and 1.2 kb in length, and each includes one or two short introns. The presumptive promoter regions contain sequences similar to the eukaryotic TATA promoter element. Two distinct, conserved sequences were found in the presumptive promoter regions of, respectively, the dauer larva-specific genes col-2 and col-6, and the primarily adult-specific genes col-7 and col-19. The domain structures of the collagen polypeptides are similar: each polypeptide contains two triple-helix forming (Gly-X-Y)n domains, one of 30–33 amino acids (aa), and the other of 127–132 aa. The latter domain is interrupted by one to three short (2–8 aa) non-(Gly-X-Y)n segments that occur at relatively conserved locations in each polypeptide. Sets of cysteine residues flank the (Gly-X-Y)n domains in all of the polypeptides. The genes can be placed into three families based upon amino acid sequence similarities. Genes within a family do not always exhibit similar developmental expression programs, suggesting that structural and regulatory regions of the genes have evolved separately. The codon usage in the genes is highly asymmetrical, with adenine appearing in the third position of 85% of the glycine codons, and 93% of the proline codons.
Persistence in food webs: holling-type food chains

Abstract In this paper we obtain sufficient conditions for the persistence of food chains modeled by Holling- or Michaelis-Menten-type dynamics. The persistence conditions involve positivity of a certain parameter which is a weighted sum of the birth-death rates for the species in the chain. Comparison with a necessary condition for persistence indicates, to some extent, the sharpness of our results.
Feedforward Adaptive-Optic Correction of Aero-Optical Aberrations Caused by a Two-Dimensional Heated Jet

A feed-forward adaptive-optic correction was made on a known, repeatable aero-optical aberration caused by a two-dimensional heated jet. Since the bandwidth requirements for traditional closed-loop adaptive-optic correction are significantly higher than current technology limitations, an unconventional feed-forward adaptive-optic correction scheme was tested to determine the feasibility of adaptive-optic corrections for aero-optical disturbances in general. The feed-forward adaptive-optic approach was successful in correcting aero-optical disturbances at a frequency of 240 Hz. The correction scheme exceeded simulated performance predictions when it was able to boost the average Strehl ratio from 0.64 without correction to 0.88 with correction.
Cardiovascular effects of parathyroid hormone in the frog,Rana catesbeiana

Mean arterial blood pressure (\(\bar P_a \)), heart rate (HR), and cardiac isometric contractile force (CF) were recorded simultaneously in the anesthetized frog,Rana catesbeiana, and the effects of the synthetic 1–34 peptide of bovine parathyroid hormone, bPTH-(1-34), on these cardiovascular parameters were tested. Doses of 10, 20, 40, 80, and 100 U·kg−1 of PTH were administered i.v. and the effects noted. Isotonic (frog) saline was used as control. Following bPTH-(1-34),\(\bar P_a \) decreased in dose-dependent fashion, reaching maximum within 60 s post-injection with a duration of 7–8 min. CF was shown for the first time to decrease in dose-dependent fashion, reaching a maximum within 70 s and exhibiting a duration of approximately 8 min. No effect of bPTH-(1-34) on heart rate was noted.
Simple and facile synthesis of water-soluble poly(phosphazenium) polymer electrolytes

Water-soluble polymer electrolytes are important industrial materials used as absorbents, rheology modifiers, network formers, and colloidal stabilizers and destabilizers. Herein, the synthesis and alkaline stability of a new class of water-soluble polymer poly(phosphazenium) electrolytes is reported. The charge on the poly(phosphazenium) structure was controlled by the amount of methylating agent used and the resultant electrolytes were water-soluble with a relatively small amount of charge per polymer chain (one charged group per 10 repeat units). Despite phosphazenium salts having excellent alkaline stability, the poly(phosphazenium) polymers with N-methylcyclohexyamino substituents degraded rapidly in alkaline solutions at 60 °C. Two-dimensional NMR was used to characterize the poly(phosphazenium) polymer electrolytes and their hydroxide ion induced degradation products.
Philosophical, ethical, and legal aspects of resuscitation medicine. I. Deferred consent and justification of resuscitation research

Informed prospective consent for clinical resuscitation research may not be possible. Deferred consent is an untenable notion. Consent to continue in research cannot be used to support a claim that there was, or would have been, consent to the initiation of research. The conditions for the justifiab
Probing the protein–nanoparticle interface: the role of aromatic substitution pattern on affinity

A new class of cationic gold nanoparticles has been synthesized bearing benzyl moieties featuring -NO2 and -OMe groups to investigate the regioisomeric control of aromatic nanoparticle-protein recognition. In general, nanoparticles bearing electron withdrawing group demonstrated higher binding affinities towards green fluorescent protein (GFP) compared to electron-donating groups. Significantly, a ~7.5 and ~4.3 fold increase in binding with GFP was observed for -NO2 groups in meta- and para-position respectively, while ortho-substitution showed similar binding compared to the unsubstituted ring. These findings demonstrated that nanoparticle-protein interaction can be controlled by the tuning the spatial orientation and the relative electronic properties of the aromatic substituents. This improved biomolecular recognition provides opportunities for enhanced biosensing and functional protein delivery to the cells.
Novel Endoscopic Finding Associated With Gastrointestinal Hemorrhage in a Post-Stem Cell Transplant Patient With Light Chain Amyloidosis

A 67-year-old woman with a incidental diagnosis of amyloidosis lambda subtype (AL-amyloid) presented with melena after therapy with heparin for an upper extremity deep vein thrombosis. She had undergone induction treatment with bortezomib, cyclophosphamide, weekly dexamethasone, and an autologous stem cell transplant 40 days prior to admission. Laboratory results revealed hemoglobin 5.9 g/dL and prothrombin time (PT) 84.8 seconds. An magnetic resonance imaging (MRI) of the abdomen and pelvis noted circumferential thickening of the duodenum and proximal jejunum. Upper endoscopy revealed multiple circular, shallow, 2–3-mm crater-like defects of the mucosa creating an appearance of a “moon surface mucosa” throughout the duodenum and jejunum (Figure 1). Duodenal biopsies revealed amyloid deposits involving the lamina propria, submucosa, and blood vessels. Congo red stain for amyloid was positive and showed birefringence under cross-polarized light microscopy (Figure 2).
Partial purification of a developmentally regulated messenger RNA from Dictyostelium discoideum by thermal elution from poly(U)-sepharose.

Abstract We have demonstrated that thermal elution from poly(U)-Sepharose is useful for separating newly synthesized messenger RNAs from steady-state mRNAs isolated from vegetative cells of Dictyostelium discoideum (Palatnik et al., 1979,1980). Because we were able to enrich between ten- and 60-fold for new transcripts, we suggested that this technique might be applicable to the purification of developmentally regulated mRNAs. The utility of the technique would, however, depend on the differential rate of synthesis of the particular mRNAs. For example, in vegetatively growing Dictyostelium amoebae the relative distribution of translation activities in newly synthesized mRNA is similar to that found in steady-state mRNA (Palatnik et al., 1979), and the technique does not lead to substantial purification of any particular mRNA species. In order to test the applicability of the method, we have studied, as a model system, changes in actin mRNA synthesis during early D. discoideum development. It has been shown that the relative concentration of actin mRNA changes during Dictyostelium development. Experiments with inhibitors of RNA synthesis have suggested that changes in the concentration of this mRNA are mediated at the transcriptional level. This conclusion is supported by the experiments of this paper: newly synthesized poly(A)-containing RNA from growing and developing cells was translated in mRNA-dependent reticulocyte lysates and the translation products were analyzed by two-dimensional polyacrylamide gel electrophoresis. At two hours of development, when the relative concentration of actin mRNA is at its peak, we find that its translation activity is also substantially enriched in the fraction of RNA that is newly synthesized. At five hours of development, when the percentage of total translatable actin mRNA has begun to decline, actin represents a much smaller percentage of the translation products coded for by this RNA fraction. The physical isolation and characterization of the newly synthesized mRNA fraction thus provides evidence that changes in the concentration of actin mRNA during Dictyostelium development occur at the level of messenger RNA synthesis. Furthermore, the results dramatically illustrate the usefulness of thermal elution from poly(U)-Sepharose for enriching for mRNAs induced by alterations in developmental or metabolic states.
Synthesis and characterization of diruthenium complexes in low oxidation states. Formation of mono- and bis-CO adducts.

A monocarbonyl diruthenium(II,II) complex of the type (dpf)4Ru2(CO), where dpf is N,N‘-diphenylformamidinate, was characterized as to its electrochemical and spectroscopic properties (UV−vis, FTIR, and ESR) under a N2 or CO atmosphere. The synthesis and X-ray structural characterization of (dpf)4Ru2(CO) are also presented.
Characterization of Polymer-metal Foam Hybrids for Use in Vibration Dampening and Isolation☆

Abstract There is an ever-increasing demand for lightweight, multifunctional material having both higher stiffness and higher damping. In many applications, higher damping in isolators can allow for beneficial changes in the natural frequencies of the vibration isolation system without deterioration in performance. Generally, simplex materials with higher damping usually have lower stiffness and vice versa. This trade-off limits the applicability of homogenous materials in such roles. Therefore, a hybrid material consisting of open cell aluminum foam as ‘skeleton’ with polymeric material introduced into the open pores could be designed to better meet these contradictory demands. This study aims to characterize the dynamic and damping properties of the composite of the aluminum foam and polymer. The hybrid material, modeled as a single degree-of-freedom spring-damper system, is loaded under a sinusoidal compressive force using a universal testing machine yielding a measure of the dynamic stiffness and damping coefficient. This paper presents the experimentally measured damping characteristics for both the unaltered foam as well as the various hybrids of polymers and aluminum foams. By modeling the hybrid as parallel springs of the aluminum and polymers, the damping due to the interface between the two materials is quantified and presented.
Ecology of benthic and epiphytic nematodes in brackish waters

Abundances of benthic nematodes from shallow waters in Tvarminne, Finland and in Ringkobing Fjord, Denmark averaged 1.2–1.5 106 individuals m−2. Less than 20 species were found. More than 80% of the individuals were made up by Anoplostoma viviparum, Chromadorita fennica, Axonolaimus spinosus, Daptonema trabeculosum and Sabatieria pulchra. S. pulchra is designated as an anoxybiotic species and is attracted to the root tips of young Potamogeton perfoliatus, whilst A. viviparum and C. fennica are oxybiotic species. Abundance of epiphytic nematodes extracted from submerged macrophytes in the Cladophora-Pilayella belt in the outer archipelago of the Finnish archipelago (July 1978) was estimated to reach 5 · 106 individuals m−2, equivalent to a biomass of 1.2 g org. C m−2. Abundance and biomass are smaller in the Potamogeton meadows in the inner archipelago, in littoral algal vegetation of the sea zone, and on sublittoral vegetation. Epiphytic nematode species composition is influenced by salinity and food availability and not by physiognomic types or silt contents of the vegetation in the Baltic Sea, European estuaries and lakes. Dominant species are: Chromadorina bioculata, Punctodora ratzeburgensis, Chromadorita tenuis, Adoncholaimus thalassophygas, Theristus acer, Monhystera parva, M. aff. filiformis and Chromadora aff. nudicapitata. A theory is proposed to explain observed seasonal changes in the species composition of epiphytic and benthic nematodes. During winter months, the submerged vegetation is mostly destroyed, being found as detritus on the sea bottom. Sampling benthic nematodes during winter thus includes epiphytic species living in the detritus. In spring the epiphytic nematodes detect the newly growing vegetation, leave the sea bottom, colonize the submerged vegetation and spend their life there.