cssi/SciSciGPT-SciSciNet huggingface dataset:
Life after pancreas transplantation: Reversal of diabetic lesions

Purpose of review Recipients of pancreas transplantation bear the burden of chronic complications of diabetes, both microvascular and macrovascular. Pancreas transplantation provides the most effective method of glycemic and metabolic control. As transplantation provides immediate relief from acute complications of diabetes, the impact of a successful transplant on long-term complications is the focus of this review. Recent findings It is increasingly recognized that a successful pancreas transplant may slow, stabilize, or ameliorate the progression of macrovascular and microvascular complications of diabetes. New understanding of the genetic and epigenetic mechanisms and pathophysiology of diabetic complications has provided new data potentially useful for prospectively studying the effect of pancreas transplant on chronic complications of diabetes. Summary Earlier correction of diabetes by pancreas transplantation decreases chronic complications. Refinements in the understanding of the tissue targets of diabetes complications and new diagnostic and imaging tools to measure them may prove useful in further studying the impact of pancreas transplantation on chronic complications of diabetes.
Confidence in the ability to communicate with physicians among low-income patients with prostate cancer.

Abstract Objectives To describe the confidence of low-income patients with prostate cancer in interacting with physicians. Men with prostate cancer need to communicate easily with their physicians when facing treatment decisions and symptom management; however, little is known about whether low-income men are confident in these interactions. Methods We used validated instruments to measure self-efficacy in patient-physician interactions, emotional well-being, symptom distress, satisfaction with care, and health-related quality of life among low-income men receiving prostate cancer treatment through a statewide public assistance program. We abstracted clinical variables from medical records. We dichotomized self-efficacy scores empirically on the basis of the sample distribution and conducted univariate and multivariate analyses. Results The self-efficacy scores were skewed toward the high scores, with 77% in the high range. Those (23%) with low self-efficacy were more likely to have poor emotional well-being, symptom distress, role limitations—emotional, low social function, and poor urinary, sexual, and bowel outcomes. In multivariate analysis, low-income men were more likely to have low self-efficacy if they were less satisfied with their care, did not have confidence in their provider, or had more symptom distress. Conclusions Among low-income patients with prostate cancer, low self-efficacy for interacting with physicians was best predicted by diminished overall satisfaction with care, low confidence in providers, and worse symptom distress. Men with low self-efficacy fared worse over a range of psychosocial outcomes and both general and disease-specific health-related quality of life.
Human factors applied to study of dentist and patient in dental environment: a static appraisal

A study was made to determine (1) the influence of various sitting positions on human endurance during prolonged sitting in dental chairs, and (2) the influence of standing as well as various sitting positions on the dentist’s operational efficiency and fatigue. The subject was able to sit for 12 continuous hours without discomfort in an experimental dental chair. The supine seated position, with the chair back at an angle of 50 degrees from the vertical, is the most acceptable position for prolonged sitting. When the dentist stands for long periods, he experiences strains which are absent when the work is performed in seated positions.
On the mechanics of impact neurotrauma : a review and critical synthesis

A computational modeling technique for the simulation of head impact mechanics is proposed as a tool for the study of traumatic brain injury (TBI). The capabilities, limitations, and consequently the utilities of this technique are discussed in light of the current computing and imaging technologies and their prospective advancement. A significant portion of the mechanics, relevant to head impact simulation, has been incorporated into this computational technique resulting in automated devices that ease the technical burden of biomechanical analysis of TBI mechanisms. A brief exposition of the concepts utilized in these devices is given and their basis in experiment is discussed.
The importance of home practice for progressive relaxation training.

Abstract The efficacy of home practice assignments was evaluated as a component of standardized progressive relaxation training. Subjects reporting general anxiety and tension problems were assigned to either a home practice relaxation, no home practice relaxation or wait-list control condition. Treatment was conducted for 10 sessions over a 5-week period. In addition, subjects in both conditions engaged in in-vivo application of their relaxation skills during a final 2-week application period. Group comparisons showed that both progressive relaxation conditions significantly improved on daily self-monitored general anxiety and tension levels relative to the wait-list control condition. Group analyses of percent subject improvements supported the effectiveness of home practice assignments, especially during the application period. No systematic differences between groups, on physiological and self-report variables, were found during several laboratory relaxation evaluation sessions. This study supports the contribution of home practice assignments to progressive relaxation training.
Asymmetric abeiian sandpile models

In the Abelian sandpile models introduced by Dhar, long-time behavior is determined by an invariant measure supported uniformly on a set of implicitly defined recurrent configurations of the system. Dhar proposed a simple procedure, theburning algorithm, as a possible test of whether a configuration is recurrent, and later with Majumdar verified the correctness of this test when the toppling rules of the sandpile are symmetric. We observe that the test is not valid in general and give a new algorithm which yields a test correct for all sandpiles; we also obtain necessary and sufficient conditions for the validity of the original test. The results are applied to a family of deterministic one-dimensional sandpile models originally studied by Lee, Liang, and Tzeng.
Structural origins of magnetic anisotropy in sputtered amorphous Tb-Fe films

Using x-ray-absorption fine-structure measurements we have obtained clear evidence for structural anisotropy in amorphous sputter-deposited TbFe films exhibiting perpendicular magnetic anisotropy. Modeling of the data shows that perpendicular anisotropy in these films is associated with Fe-Fe and Tb-Tb pair correlations which are greater in plane and Tb-Fe correlations which are greater perpendicular to the film plane. Upon annealing at 300 \ifmmode^\circ\else\textdegree\fi{}C the measured structural anisotropy disappears and the magnetic anisotropy decreases to a level consistent with magnetoelastic interactions between the film and substrate.
Semantic influences on morphological facilitation: Concreteness and family size

Two semantic variables, concreteness and morphological family size, were examined in a single word and a primed lexical decision task. Single word recognition latencies were faster for concrete relative to abstract targets only when morphological family size was small. The magnitude of morphological facilitation for primes related by inflection was greater than by derivation although both revealed a very similar interaction of concreteness and family size. In summary, concreteness influenced morphological processing so as to produce slower decision latencies for small family abstract than concrete words both in a single word and in a morphologically primed context. However, magnitudes of facilitation in isolation from baselines provided an incomplete account of morphological processing.
A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway

Abstract Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Previously published results have established that chronic cocaine administration (30–45 mg/kg per day, 10–14 days) resulted in an upregulation of TH gene expression in dopaminergic pathways of rats. The present studies tested the effects of a tropane analog, PTT (2β-propanoyl-3β-(4-tolyl)-tropane), on TH expression. This drug has similar actions to cocaine, but possesses markedly different pharmacokinetics (20 times more potent at binding the dopamine transporter, markedly increased metabolic stability, and 10–20 times more potent in behavioral measures). Moreover, PTT demonstrates an increased selectivity for the dopamine (DA) and norepinephrine (NE) transporters compared with cocaine. In direct contrast to the previously reported effects of cocaine, 10 days of PTT administration (3.0 mg/kg per day, i.p.) produced a uniform downregulation of TH protein and activity gene expression. TH activity and immunoreactive protein where decreased by 54 and 69%, respectively in the nucleus accumbens. Within the ventral tegmental area, TH activity and protein were decreased by 33 and 19%, respectively. The underlying mechanisms for these fundamental differences are unclear, but likely reflect varying and selective affinities and lengths of occupancy at biogenic amine transporters.
Aortoatrial fistula complicating transjugular intrahepatic portosystemic shunt by protrusion of a stent into the right atrium: radiologic/pathologic correlation.

Numerous procedural complications of creation of a transjugular intrahepatic portosystemic shunt (TIPS) have been reported. In this article, a case of an aorto–right-atrial fistula after the revision of a TIPS is reported. The fistula developed from the free edge of a stent that protruded into the right atrium. The patient developed progressive right heart failure and eventually died of complications of right heart failure. Prevention of this potential complication with careful catheter manipulations under fluoroscopic observation around newly placed stents is recommended to prevent dislodgement of the stents. Careful deployment that avoids extension of the stent into the right atrium is essential to avoid the complication of cardiac perforation.
Thermoduric Bacteria in Milk. III. The Effect of Changing Agar and Temperature of Incubation for Plate Counts on the Problem of Thermoduric Bacteria in Milk

Summary Data on 100 lots of milk examined both before and after pasteurization shows that lowering the temperature of incubation for plate counts from 37° C. to 32° C. or changing from the old standard agar to tryptone glucose extract milk agar, or making both changes simultaneously, not only results in higher counts on both raw and pasteurized milk, but also results in a higher percentage of the organisms counted in the raw milk being classified as thermoduric. Three different methods of pasteurization all gave this same result.
Intraoperative phacoemulsification complication rates of second- and third-year ophthalmology residents a 5-year comparison.

Objective To determine whether year of residency is associated with intraoperative phacoemulsification complication rates. Design Retrospective cohort study. Participants One attending physician supervised 691 resident-performed phacoemulsification procedures on 492 patients. Second- and third-year residents performed 228 and 463 cases, respectively. Methods All resident-performed phacoemulsification procedures performed between October 2003 and June 2008 and supervised by one attending surgeon (SR) were considered for this study. Data were collected on the residency year of the physician performing the surgery, preoperative risk indicators, and intraoperative complications, including anterior and posterior capsular tears with or without vitreous loss, zonular dialysis or dehiscence, burns, nuclear fragment loss, and Descemet's membrane tear. Cases were classified as difficult if they had 1 or more preoperative risk indicators including: pseudoexfoliation; proliferative diabetic retinopathy; prior vitrectomy; a 4+ dense, white, or brunescent cataract; current Flomax (Boehringer-Ingelheim, Ingelheim, Germany) use, pre-existing zonular dialysis; and intraoperative use of Trypan blue, iris hooks, or pupil dilator. Intraoperative complications are presented as rate per 100 surgeries (95% confidence intervals [CIs]). Main Outcome Measures Intraoperative complication rates and case difficulty. Results Fifty-three patients experienced at least 1 complication, with 25 cases experiencing multiple complications. Intraoperative complication rates were similar among second- and third-year resident groups (7.9% vs. 7.6%; P = 0.88). Similarly, vitreous loss rates among second- and third-year residents were comparable (4.8% vs. 3.0%; P = 0.27). Risk indicators were more common among third-year cases (24.6% vs. 15.8%; P = 0.008). Having 1 or more risk indicators increased the odds of an intraoperative complication (odds ratio [OR], 3.09; 95% CI, 1.73–5.49). After controlling for risk indicators, second-year resident surgeries still had a similar risk of intraoperative complications as third-year resident surgeries (OR, 1.15; 95% CI, 0.6–2.19). Conclusions The year of residency did not significantly influence intraoperative complication rates, even after controlling for differences in case difficulty. Financial Disclosure(s) Proprietary or commercial disclosure may be found after the references.
G protein complement of SV40-transformed ciliary epithelial cells

Guanine nucleotide-binding proteins (G proteins) are a family of receptor-coupled signal-transducing proteins that regulate a variety of second-messenger systems and ion channels. The complement of G proteins in SV40-transformed pigmented and nonpigmented ciliary epithelial cells was determined by Western blot analysis utilizing peptide and holoprotein derived antisera to known G protein alpha and beta subunits and cholera toxin catalyzed ADP-ribosylation. The complement of alpha subunits found in both SV40-transformed NPE and PE cells includes Gs alpha and all three members of the Gi alpha family. Neither cell type contains Go alpha or Gz alpha. Both cell lines contain beta 35 and beta 36. Future studies will examine the functional involvement of these G proteins in the regulation of aqueous humor stimulus-secretion coupling.
Efficacy and Feasibility of Laparoscopic Redo Fundoplication

Nearly 15% of patients who undergo anti-reflux surgery report recurrent symptoms on long-term follow-up and may be candidates for redo anti-reflux surgery (redo-ARS). In the last 10 years, several studies have evaluated the feasibility and short-term results of redo-ARS. The purpose of the present study was to critically review our experience with 102 redo fundoplications with short- to medium-term follow-up and special emphasis on subjective outcomes for redo-ARS. A retrospective chart analysis was done on consecutive 102 redo fundoplications performed between December 2003 and March 2008. The patients were divided into two groups, the open group (group A) and the laparoscopic (group B). Subjective symptom analysis was performed on an annual basis using a standard questionnaire. There was no significant difference in mean age, body mass index (BMI), or time since first surgery between the two groups. Significant differences were noted between operative time, estimated blood loss, and median hospital stay between the two groups. A total of 16 patients were found to have short esophagus and underwent Collis gastroplasty. Complications included 11 hollow viscus injuries seen in group A and 13 such injuries in group B. There was significant improvement in all symptom scores in the two groups, along with a significant decrease in the use of acid suppression therapy. In the open group 58% of patients rated their satisfaction as excellent compared to 90% in the laparoscopic group. This study clearly establishes the safety and efficacy of redo laparoscopic anti-reflux surgery with excellent outcomes after short- to medium-term follow-up.
On the Present Halting of Global Warming

The rise in global average temperature over the last century has halted since roughly the year 2000, despite the fact that the release of CO2 into the atmosphere is still increasing. It is suggested here that this interruption has been caused by the suspension of the near linear (+ 0.5 C/100 years or 0.05 C/10 years) temperature increase over the last two centuries, due to recovery from the Little Ice Age, by a superposed multi-decadal oscillation of a 0.2 C amplitude and a 5060 year period, which reached its positive peak in about the year 2000—a halting similar to those that occurred around 1880 and 1940. Because both the near linear change and the multi-decadal oscillation are likely to be natural changes (the recovery from the Little Ice Age (LIA) and an oscillation related to the Pacific Decadal Oscillation (PDO), respectively), they must be carefully subtracted from temperature data before estimating the effects of CO2.
Calcium, Phosphorus, and Sodium Concentrations in Cheddar Cheese

Abstract Commercial Cheddar cheese from 26 cheese plants in 7 midwestern states were analyzed for their Ca, P, and Na levels. Thirty-five cheese gave mean values for Ca of .715% with a range of .606 to .830%; for P .501% and a range of .442 to .556%; and for Na .65% (NaCl 1.64%) with a range of .48 to .85% (NaCl 1.22 to 2.16%). The correlation coefficient for Ca and P was r=.90, but as Ca concentration decreased from the norm by 3 mmol/kg, P concentration decreased only 2 mmol/kg. Sodium variation among cheeses indicated a lack of uniformity in industrial salting practices.
Multiresolution linear discriminant analysis: efficient extraction of geometrical structures in images

Currently popular feature extraction tools (e.g., Gabor, wavelet analysis) do not economically represent edges in images. As a step towards solving this problem, the wedgelet transform was recently proposed D.L. Donoho, [1999]; this transform provides nearly optimal representation of objects in the Horizon model, as measured by the minimax mean-squared error. However, there is no reason to assume that the components useful for representing pixel values must also be useful for discriminating between regions in an image. Thus, having the successful extraction of edges as our goal, we propose a novel image analysis method-namely, multiresolution linear discriminant analysis (MLDA). In MLDA, analogously to the wedgelet transform, we seek directions that are efficient for discrimination. The MLDA framework comprises the following components: the MLDA atom, dictionary, tree, graph, and MLDA-based algorithms. In this paper, we explain these components and demonstrate the powerful expressiveness of MLDA, which gives rise to fast geometrical-structure-analysis algorithms.
Comment on the Review of African Societies in Southern Africa

My attention has been drawn to Hoyt S. Alverson's recent review of Leonard Thompson's African Societies in Southern Africa (AA 73:353-354). I take grave exception to your reviewer's comments on the volume, which do injustice to the published results of a significant and productive conference. Mr. Alverson alleges that African Societies "hardly stands in itself as a balanced study of Southern Africa, its peoples, or their culture history." Of course it does not, nor is it supposed to. The papers were presented to a working conference of historians actively engaged in South African historiography. All the participants were specialists, many of them working in obscure aspects of South African history where methodology is still uncertain and research conclusions are still highly tentative. He accuses the historians of taking anthropology lightly. Most of the contributors have had considerable training in anthropology-research like that of Martin Legassick on Sotho-Tswana peoples before 1800 cannot be undertaken without many months of detailed reading in the anthropological literature. The same applies to the Iron Age archaeology described in the first two chapters.
Spatial bias in multi-atlas based segmentation

Multi-atlas segmentation has been widely applied in medical image analysis. With deformable registration, this technique realizes label transfer from pre-labeled atlases to unknown images. When deformable registration produces error, label fusion that combines results produced by multiple atlases is an effective way for reducing segmentation errors. Among the existing label fusion strategies, similarity-weighted voting strategies with spatially varying weight distributions have been particularly successful. We show that, weighted voting based label fusion produces a spatial bias that under-segments structures with convex shapes. The bias can be approximated as applying spatial convolution to the ground truth spatial label probability maps, where the convolution kernel combines the distribution of residual registration errors and the function producing similarity-based voting weights. To reduce this bias, we apply a standard spatial deconvolution to the spatial probability maps obtained from weighted voting. In a brain image segmentation experiment, we demonstrate the spatial bias and show that our technique substantially reduces this spatial bias.
Recurrence phenomenon in dissipative systems

We study weakly dissipative two-parameter generalized standard maps with a view to understanding the effect of dissipation on the recurrences of periodic orbits of the Hamiltonian maps. We obtain fractal diagrams and understand recurring periodic attractors as due to paird of saddle-node bifurcations. These bifurcations occur in place of each of the stability exchanges and form gaps in the fractal diagram where the periodic attractor does not exist.
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages

In this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.
A Comparison of Four Studies Using A Conditional Model for the Determination of Worker Needs

Before management can utilize unsatisfied worker needs to modify worker behavior, a practical technique is required for the measurement of the various dimensions of job satisfaction and the transformation of that data into a cost-effective behavioral modification program. This report describes such a technique developed by the authors and successfully applied to four separate studies of job satisfaction involving four diverse work groups.
A β-galactosidase gene is expressed during mature fruit abscission of ‘Valencia’ orange (Citrus sinensis)

b-galactosidases have been detected in a wide range of plants and are characterized by their ability to hydrolyse terminal non-reducing b-D-galactosyl residues from b-D-galactosides. These enzymes have been detected in a wide range of plant organs and tissues. In a search for differentially expressed genes during the abscission process in citrus, sequences encoding b-galactosidase were identified. Three cDNA fragments of a b-galactosidase gene were isolated from a cDNA subtraction library constructed from mature fruit abscission zones 48 h after the application of a mature fruit-specific abscission agent, 5-chloro-3-methyl-4nitro-1H-pyrazole (CMN-pyrazole). Based on sequence information derived from these fragments, a full-length cDNA of 2847 nucleotides (GenBank accession number AY029198) encoding b-galactosidase was isolated from mature fruit abscission zones by 59- and 39-RACE approaches. The b-galactosidase cDNA encoded a protein of 737 amino acid residues with a calculated molecular weight of 82 kDa. The deduced protein was highly homologous to plant b-galactosidases expressed in fruit ripening. Southern blot analysis demonstrated that at least two closely related b-galactosidase genes were present in ‘Valencia’ orange. Temporal expression patterns in mature fruit abscission zones indicated b-galactosidase mRNA was detected 48 h after treatment of CMN-pyrazole and ethephon in mature fruit abscission zones. b-galactosidase transcripts were detected in leaf abscission zones only after ethephon application. The citrus b-galactosidase was expressed in stamens and petals of fully opened flowers and young fruitlets. The results suggest that this bgalactosidase may play a role during abscission as well as early growth and development processes in flowers and fruitlets.
Silicon-on-Glass (SiOG) substrate technology: Process and materials properties

This paper is an introduction to a new Silicon-on-Glass substrate technology. The fabrication process and material properties of SiOG are presented. The semiconductor film has good electrical properties, comparable to other SOI technologies, and is strongly attached to a large area transparent substrate via an in-situ barrier layer compatible with FPD processing.
Perioperative Complications following Artificial Urinary Sphincter Placement

Purpose: We evaluated perioperative complications in patients undergoing primary artificial urinary sphincter placement and the potential impact of these complications on device outcomes.Materials and Methods: During the 2-year period from 2012 to 2014 we retrospectively evaluated the outcomes of 197 consecutive artificial urinary sphincter implantation procedures performed at our institution for post-prostatectomy incontinence. Of these cases 100 that were primary implantations comprise the study cohort. Perioperative complications, defined as those occurring within 6 weeks postoperatively, were classified by the Clavien-Dindo classification. After office evaluation at 6 weeks patients were followed for symptoms. Patient followup was obtained through office examination and telephone correspondence.Results: Patients undergoing primary artificial urinary sphincter implantation had a median age of 71.5 years (IQR 66, 76). The overall rate of any complication (Clavien I-V) within 6 weeks of surgery was 35%, ...
Effect of environmental pH on morphological development of Candida albicans is mediated via the PacC-related transcription factor encoded by PRR2

The ability to respond to ambient pH is critical to the growth and virulence of the fungal pathogen Candida albicans. This response entails the differential expression of several genes affecting morphogenesis. To investigate the mechanism of pH-dependent gene expression, the C. albicans homolog of pacC, designated PRR2 (for pH response regulator), was identified and cloned. pacC encodes a zinc finger-containing transcription factor that mediates pH-dependent gene expression in Aspergillus nidulans. Mutants lacking PRR2 can no longer induce the expression of alkaline-expressed genes or repress acid-expressed genes at alkaline pH. Although the mutation did not affect growth of the cells at acid or alkaline pH, the mutants exhibited medium-conditional defects in filamentation. PRR2 was itself expressed in a pH-conditional manner, and its induction at alkaline pH was controlled by PRR1. PRR1 is homologous to palF, a regulator of pacC. Thus, PRR2 expression is controlled by a pH-dependent feedback loop. The results demonstrate that the pH response pathway of Aspergillus is conserved and that this pathway has been adapted to control dimorphism in C. albicans.
The political anatomy of community health policy in Australia, 1972-1982.

Abstract This article seeks to account for the survival of the 1973–1975 Labor government's new Community Health policy during the conservative coalition government (1975–1983) (which had managed to completely abolish Labor's national Medibank health insurance program). Through extensive interviews with 74 people who were directly involved in the policy process at national, state and local levels, as well as from other sources of information, inquiry is made into the issues and circumstances that were taken into account in the decisions that affected the course of policy from 1972–82. The important political and economic forces included party politics, federal‐state relations, the national economy, the direction of other fiscal and health policies, private and governmental interest groups, administrative nets, and the mass media. The not surprising conclusion is that changes in Community Health policy did not depend on its effectiveness but rather on the balance of political, economic and organizational p...
PadMaster: Banging on Algorithms with Alternative Controllers

This paper will describe the current implementation of PadMaster, a real-time improvisation environment running under the NextStep operating system on both NeXT hardware and Intel PCs. The system was designed with the Mathews/ Boie Radio Drum in mind, but can now use alternative controllers, including widely available graphics tablets. The current version adds soundfile playback and algorithms to the preexisting palette of performance options. 1.0 The PadMaster program PadMaster is a real-time improvisation environment written in Objective C that currently runs on NeXT workstations or Intel PCs running the NEXTSTEP operating system. PadMaster uses the MusicKit [4, 5, 6] as the basic foundation for controlling and performing musical events and the NeXT Soundkit as the basic resource for soundfile playback (an extension is in the works which will allow PadMaster to control other networked workstations for soundfile and or MIDI information playback). 2.0 Basic concepts: a virtual surface, controllers, pads and scenes The performer interacts through the selected controller with a virtual surface that is modelled on the screen of the computer. This virtual surface contains one of more “Pads” which are the basic performance units of PadMaster. Pads are non-overlapping rectangular sections of the surface (of arbitrary size) and can be triggered through actions of the performer. Pads can control the playback of MIDI information or soundfiles either through sequences or algorithms. A Pad can react in different ways to a trigger event and can also link some of its control parameters to continuous position information provided by the selected controller. A set of Pads that are defined within the same surface are called collectively a “Scene”. PadMaster allows an indefinite number of Scenes to be defined. The performer interacts with the current scene and can switch between them during the performance, in effect redefining the besynth #1
Reversible Cerebellar Ataxia Due to Ovarian Teratoma (PD2.008)

OBJECTIVE: Case report of reversible cerebellar ataxia due to ovarian teratoma. BACKGROUND: Cerebellar dysfunction is a common paraneoplastic syndrome associated with gynecological and breast tumors, small-cell lung cancer and Hodgkin9s lymphoma. We present the case of a 22-year-old woman with acute cerebellar ataxia that subsided upon removal of an ovarian teratoma. RESULTS: The patient presented with acute vertigo, vomiting, oscillopsia and dysarthria. Her initial exam was notable for nystagmus, titubation, limb ataxia and dysmetria. Her gait was severely ataxic, requiring full assistance to stand and walk. A lumbar puncture demonstrated a lymphocytic pleocytosis and a slight increase in her immunoglobulin G. Brain magnetic resonance (MR) imaging and MR angiography were unrevealing. Laboratory tests including cerebrospinal fluid and serum paraneoplastic studies (anti-Yo, Hu, Tr and GAD65 antibodies) were unremarkable. CT scan of the pelvis was done, revealing bilateral ovarian masses, although a PET scan and mammogram showed no additional lesions. She was treated with intravenous methylprednisolone, immunoglobulin and plasma exchange with minimal benefit. Both ovarian masses were surgically removed, and pathology was consistent with a mature left ovarian teratoma. Over the course of a year, she slowly regained her ability to walk and do daily activities. A whole body and brain PET scan showed no signs of active malignancy. Four years later, her symptoms were completely resolved and she was able to return to school. Surveillance ultrasound of the ovaries showed a dermoid cyst, but she continued to do well with no further recurrence. CONCLUSIONS: Our case suggests that acute cerebellar ataxia may be associated with an underlying ovarian teratoma. To our knowledge, this is the first report of such an association although another reversible disorder, anti-NMDA receptor encephalitis has been well-described. Our case may represent a new category of immune-mediated cerebellar ataxia that is reversible with treatment of the underlying tumor. Disclosure: Dr. Park has nothing to disclose. Dr. Liang has received personsal compensation for activities with Teva Neuroscience as a consultant. Dr. Liang has received research support from Allergan.
Healthcare Data Analytics Challenge

Online patient/caregiver support forums such as, cancer compass, ehealthforums, and patientslikeme, allow patients and caregivers to post health-related questions. In many of these forums, there is a significant volume of repetitive questions. One possible reason for this repetition could be that as forums grow longer, patients and caregivers do not have the time or patience to read through previous questions before posting their own question. The challenge here is to design and implement a system that, for a new question q, identifies a maximum of three existing questions that are most similar to q. In this challenge, we experimented with a variety of methods and representations to address this task, including approaches that leveraged topic modeling, distributional semantics (word2vec), and term frequency-inverse document frequencies (TF-IDF) to induce the vector representation of questions. For similarity measures, we used cosine similarity and the rescaled dot product over these feature spaces. Despite our experimentation with more recent methods, we found that simple TF-IDF with stemming using cosine similarity seemed to result in the best performance.
Mitotic Activity and Cell Number of Denervated Parotid of Adult Rat

SummaryUnilateral removal of the auriculotemporal nerve to parotid of adult rat results in decrease in gland size, total DNA and RNA. Some of these changes are evident 4 days after denervation; by 14 days, decreases in all three parameters are pronounced, and remain at this level even after 84 days. If the superior cervical ganglion is unilaterally removed, weight and DNA of the denervated gland are increased 4 days after denervation, but after 14 days, DNA is decreased to levels of the innervated gland, and small decreases in RNA and gland size are seen. With either parasympathectomy or complete postganglionectomy, DNA is reduced by approximately 16% when comparison is made with innervated glands in the same animals. In view of the gland enlargement observed 4 days after sympathectomy, mitotic activity was followed during the first 6 days following denervation. Marked mitotic activity was observed in both Sx and PxSx glands, and maximal levels of 15-19 per 1000 acinar cells were recorded after 2 days; Px...
IS-047 Making Hospitals Safer For Children: Early Warning Scores And Safe Systems

There is increasing evidence highlighting that missed deterioration in hospitalised children is a significant problem with increased risk of mortality and morbidity (Odetola et al 2007). Currently Paediatric Early Warning scoring systems (PEWs) are advocated by (CEMACH 2008, DOH 2012) for use as a safety measure to assist in the identification of seriously ill or deteriorating children, in hospital, so that targeted care can be delivered to prevent serious adverse events. However there is a paucity of evidence to inform the development of such scores, with ad hoc score development based on local consensus opinion or inadequately validated scores. This session will explore the challenges of studying this complex intervention, review evolving evidence, identify gaps in the literature, and make recommendations for future research.
“Inclusive Entrepreneurship”: A Process for Improving Self-Employment for People with Disabilities

ABSTRACTThis article describes the theoretical framework, processes, and outcomes associated with a U.S. Department of Labor, Office of Disability Employment Programs (ODEP)-funded project: “Start-UP NY.” Beginning in 2007, ODEP funded three Start-UP projects throughout the United States to test and demonstrate improved practices supporting entrepreneurship among people with diverse disabilities, including those with mental illnesses and veterans with disabilities. The New York project coined the term “Inclusive Entrepreneurship” to describe a model that promoted change at the individual, program, and systems level to improve the rate of small business development by people with disabilities. The author describes the genesis of the project, its intended effects and the lessons learned along the way that resulted in either course corrections or improvements, He then discusses how the project has been sustained and provides recommendations for replicating the project’s approach and methods in other United S...
Microbiological studies on growth factor for L. bifidus var. pennsylvanicus.

Summary1. The results of microbiological assays on a large number of oligosaccharides obtained from human milk and on simple derivatives (disaccharides or simple synthetic compounds) of N-acetyl-D-glucosamine are reported. The high microbiological activity of 4-0-β-D-galactopyranosyl-N-acetyl-D-glucosamine and of ethyl- and n-propyl-N-acetyl-β-D-glucosamine has not been exceeded by any other compound tested. 2. The “true” specific bifidus factor has either still to be found or several related compounds may act as precursors or in synergistic combination.
The politics and dynamics of energy transitions: lessons from Colorado's (USA) “New Energy Economy”:

This article examines the political dynamics of energy transitions in a case study of the State of Colorado's (USA) efforts to create a “New Energy Economy” through a series of legislative and admi...
Endothelial albumin permeability is shear dependent, time dependent, and reversible

Altered permeability of vascular endothelium to macromolecules may play a role in vascular disease as well as vascular homeostasis. Because the shear stress of flowing blood on the vascular wall is...
The Design of Supranational StructuresAn Economic Perspective

The nature of transnational public goods with international ranges of benefit spillovers is shown to justify, in some instances, the operation of a supranational structure in order to foster allocative efficiency. The design of an “optimal” supranational body is investigated from an economic perspective that weighs both transaction costs and benefits that are derived from the linkage of national entities. In particular, transaction costs in the form of decision-making, interdependency, and enforcement costs must be matched at the margin with transaction benefits in the form of efficiency gains, scale economies, and enlarged communication possibilities if optimal tightness of the link is to be determined. Additionally, the optimality condition for a complex supranational system requiring multiple supranational linkages is depicted. The role of technology with respect to the nature of transnational public goods and the design of supranational formations is briefly analyzed.
Shock-Wave Lithotripsy: How Much is Enough?

Over 300,000 patients worldwide have received shock-wave treatment for their renal or ureteral stones. There seems to be little question that this method of minimally-invasive treatment of calculi (1) is as effective as open surgery or percutaneous procedures when used on properly-selected patients (2). On the other hand, the major benefit attributed to shock-wave lithotripsy (ESWL) derives from its relative lack of morbidity and similar cost when compared to percutaneous renal stone surgery (3). Of course, some patients require treatment by combined modalities such as ESWL coupled with percutaneous lithotripsy (4). Few now undergo classical open surgery for renal stones.
2-D DOA estimation using MUSIC algorithm with uniform circular array

As one key technology in third generation communication, smart antenna can effectively increase system capacity and reduce co-channel interference for deployment and implementation of information and communication technologies in the Smart Cities. This article expounds in detail how to obtain Direction of Arrival (DOA) information using Multiple Signal Classification (MUSIC) algorithm with Uniform Circular Arrays (UCA) based on theoretical analysis of receiving spatial signal by uniform circular arrays. A number of simulation results were carried using MATLAB and compared with the experimented one. The comparison show that proposed MUSIC algorithm is more accurate and stable.
Optimizing follow-up after anatomic total shoulder arthroplasty

Background With increases in both total shoulder arthroplasty (TSA) volumes and patient life expectancies, the number of patients requiring follow-up after shoulder arthroplasty continues to grow exponentially. The purpose of this study is to establish a data-based follow-up schedule minimizing unnecessary patient and health care system costs without sacrificing patient care. Methods Between January 1975 and January 2013, 2786 consecutive anatomic TSAs were performed at our institution. All shoulders undergoing reoperation/revision were reviewed to identify the common modes of failure and times to failure. Results A total of 208 shoulders (7.5%) required reoperation. Early failure mechanisms included instability, rotator cuff tears, and infection, with 63% of these reoperations occurring within 2 years. Later failures included mechanical failures (including component loosening) and periprosthetic fractures, with no identifiable peak occurrence. After 2 years, TSA failed at an average rate 1.1% per year. Conclusions TSA failure after 2 years is uncommon and triggers surgical intervention in approximately 1% of patients per year. Routine in-person surveillance of all patients on a scheduled basis may not be necessary and would increase patient and other health care costs. We recommend in-person visits to assess healing, direct rehabilitation, and manage soft tissue or infectious issues until 2 years, with planned, periodic patient contact by mail and radiographic evaluation of patients with poor or worsening outcomes thereafter, unless patient concerns arise or a newer implant design warrants closer clinical assessment.
A Procedure for Measuring the Benefit of Electricity Service

Abstract Pricing strategies are an effective means of controlling electricity loads. However, in order to apply control theory methods to the analysis and design of pricing strategies, one must formulate an objective function that provides a quantitative measure of the benefits and costs to be realized under a particular strategy. Cost may be readily measured in terms of monetary units; the measurement of benefits is quite difficult. Two reasons for this difficulty are: (1) the actual amount of money that a customer is willing to pay for services is not observable, and (2) the value of service depends on the quality as well as the quantity. These issues are of considerable concern in analyzing strategies that try to control loads through differential pricing or load control devices. This paper proposes an approach for measuring the benefits of electricity service. The key to the approach is to focus on a relative measure of benefits rather than an attempt to estimate a monetary worth for the service. This technique has been successfully employed in electric utility planning models
Subspace Clustering via Tangent Cones

Given samples lying on any of a number of subspaces, subspace clustering is the task of grouping the samples based on the their corresponding subspaces. Many subspace clustering methods operate by assigning a measure of affinity to each pair of points and feeding these affinities into a graph clustering algorithm. This paper proposes a new paradigm for subspace clustering that computes affinities based on the corresponding conic geometry. The proposed conic subspace clustering (CSC) approach considers the convex hull of a collection of normalized data points and the corresponding tangent cones. The union of subspaces underlying the data imposes a strong association between the tangent cone at a sample $x$ and the original subspace containing $x$. In addition to describing this novel geometric perspective, this paper provides a practical algorithm for subspace clustering that leverages this perspective, where a tangent cone membership test is used to estimate the affinities. This algorithm is accompanied with deterministic and stochastic guarantees on the properties of the learned affinity matrix, on the true and false positive rates and spread, which directly translate into the overall clustering accuracy.
Integrating Family Medicine and Community Pharmacy to Improve Patient Access to Quality Primary Care and Enhance Health Outcomes

Health care in the US remains dysfunctional despite well-intentioned efforts to revitalize the system. Delivery is fragmented, per capita investment is the highest of any nation in the world, and the return on the health care dollar ranks as one of the lowest of industrialized nations.[1-3][1]
A study of three Indonesian teachers' participation in a US graduate program

Many research have focused on the identity construction of Asian teachers (see, among others, Chang, 2004; Cui, 2006; Ha & Que, 2006; Tang, 1997; and Tsui, 2007). Among all these, studies focusing on Indonesian teacher identity construction are rare. Thus, the study aimed at filling the gap. The study examined the identity development of three Indonesian English teachers navigating in an in-service program in the US. The study found that their identities varied with one subject experienced identity shift while others illustrate the case of identity as relatively permanent. Whereas previous studies on L2 teachers have focused primarily on the construction of teacher identity per se, the findings of the study indicated that the construction of the three Indonesian teacher identities were grounded in other identity options such as nonnative speaker, gender as well as learner identity.
CAD/CAM Custom Abutments for Esthetic Anterior Implant-Supported Restoration: Materials and Design

The purpose of this review is to discuss the use of computer-aided design and computer-aided manufacturing (CAD/CAM) custom abutments in the anterior region with a focus on abutment design and material selection. Advantages, disadvantages, and complications of CAD/CAM abutments are also considered. CAD/CAM abutments are available in various materials and with different connection platforms to the implant in order to meet esthetic, functional, and biological demands. Use of CAD/CAM concepts in the fabrication of custom abutments allows for definite advantages over both stock abutments and conventional cast custom abutments. CAD/CAM technology should be considered when restoring dental implants in the esthetic zone.
Design Of New Precision Machine Elements

History motivates the creation of lower cost and higher precision machine elements. This paper introduces a new low cost design for magnetically preloaded air bearings and self-compensating hydrostatic bearings. In addition, a new design concept for a low cost precision cylindrical grinding machine is introduced where the axis of motion carriages act as integral structural elements of the supporting frame to create a very small and rigid structural loop.