cssi/SciSciGPT-SciSciNet huggingface dataset:
Education of Health Care Providers for the Rural Setting: A Family Nurse Practitioner Demonstration Program*

Spurred by mass concern over shortages of health care providers, the country's educational system has, over the past ten years, produced an ample supply (in some areas a near glut) of health care professionals. Studies demonstrate, however, that these professionals tend to cluster in the affluent metropolitan and suburban areas. Residents of rural areas are still significantly underserved. In the heavily rural southern half of Georgia, this problem has reached a critical peak. Georgia Southern College (GSC) is a rural based college located in the heart of rural south Georgia. In order to address some of the health care problems of its constituency, GSC, with federal support, established a Nursing Department and a Family Nurse Practitioner program with a commitment to recruit nursing students from the rural area, educate them in rural settings, and provide appropriate preparation for the unique experience of working in the rural environment. The program has been very successful in producing highly skilled graduates who do stay and work in the rural areas, providing health care at reasonable costs. This paper describes the setting (rural south Georgia), the need, the program implementation, and the impact (numbers of graduates actually working in rural settings, and innovative projects initiated by graduates).
Fatigue Life Prediction of Heavy-Duty Riveted Steel Gratings in Bridge Decks

AbstractHeavy-duty riveted steel gratings often occur as open-grid deck systems used in movable bridge construction and in rehabilitation projects due to their light weight compared with conventional systems. Open-grid decks have been used in a number of bridges, with the majority fabricated as welded decks. Field and laboratory experience with heavy-duty riveted steel gratings indicates improved fatigue performance compared with welded decks, but no specific provisions currently exist. This study explored a fatigue life prediction methodology for riveted gratings using fracture mechanics. The models involve crack growth rate relations and approximate stress intensity factor solutions for a crack in a bearing bar of the grating. Two failure modes of the riveted gratings were considered based on results of fatigue testing of both full-size and smaller-size samples of a 37R5 lite panel under various stress ranges. Results from the fracture mechanics approach compared well with experimental results. The prop...
Functional consensus for mammalian osmotic response elements.

The molecular mechanisms underlying adaptation to hyperosmotic stress through the accumulation of organic osmolytes are largely unknown. Yet, among organisms, this is an almost universal phenomenon...
Exploring the dynamics of South Africa’s illegal abalone trade via routine activities theory

The illicit trade in African wildlife has a lengthy history with devastating effect on select species. While considerable research addresses the impact of the trade on rhinoceros and elephant, the poaching of the reptiles, birds and marine life comprises a significantly greater volume of wildlife yet receives somewhat less attention. To better understand these aspects of the illegal trade, this study focuses on abalone, a highly desired and protected shellfish found off the Western Cape of South Africa and heavily targeted by poachers to meet demand in South Africa and parts of East Asia. Relying on qualitative data from field research, this study examines the nature of the illicit trade including poachers, smuggling techniques and the challenges for enforcement of the conservation laws through the lens of routine activity theory. The results indicate that routine activities theory may provide a viable theoretical construct to better understand the nature of abalone poaching and develop solutions to the problem.
Search for New and Unusual Strangeonia using CLAS

We perform a survey of the proton, K^+, K^- -3 charged track data, taken by the CLAS detector for the HyCLAS experiment during the g12 run-period at Jefferson Lab. We aim to study the strong decay amplitudes, partial widths and production channels of strangeonia from the CLAS g12 dataset. HyCLAS was motivated by the experimental results for gluonic hybrid meson candidates, theoretical Lattice QCD, and Flux-tube Model calculations and predictions. The experiment was designed and conducted to search and observe new forms of hadronic matter through photoproduction.
Surface Chemistry of 2-Iodoethanol on Pd(111): Orientation of Surface-Bound Alcohol Controls Selectivity

Temperature-programmed desorption (TPD), high-resolution electron energy loss spectroscopy (HREELS), and density functional theory (DFT) were used to investigate the thermal surface chemistry of 2-iodoethanol (ICH2CH2OH) on Pd(111). 2-Iodoethanol undergoes C–I scission upon adsorption at low temperatures, resulting in 2-hydroxyethyl (−CH2CH2OH) formation. At low coverage, this intermediate decomposes to form carbon monoxide and hydrogen during TPD. At higher coverage, hydroxyethyl reacts to produce ethanol, ethylene, water, 2-iodoethanol, and acetaldehyde, with nearly complete suppression of the decarbonylation pathway. DFT and HREELS results indicate that the coverage dependence of the reaction pathways is correlated with a change in the adsorption geometry of hydroxyethyl. At low coverage the C–O bond lies parallel to the surface, while at higher coverage it is shifted into a perpendicular position. Adsorbed iodine is observed to play a significant role in blocking sites and favoring the upright adsorpt...
Novel Hybrid Abrasive Particles for Oxide CMP Applications

In the present research, novel abrasive particles are investigated in order to carry out CMP at relatively low down force (low mechanical stress) yet achieve desirable removal rates and superior post CMP surface quality (reduced scratches). Hybrid abrasives are developed where the composition of the polymeric particles formed via colloidal precipitation is modified with inorganic segments to reduce surface damage during CMP. The composition is controlled by changing the time for condensation and hydrolysis of the inorganic oxide. Characterization of these particles is performed by FTIR spectroscopy, dynamic light scattering, and electron microscopy (TEM/SEM). Tribological characteristics during polishing employing these novel particles are studied on a bench-top CMP tester. Surface roughness and defectivity are estimated using Atomic Force Microscopy (AFM).
Analysis of common defects in the clinical trial reports of traditional Chinese medicines

Base on the view points of evaluation,the common defects were analyzed in order to improve the quality of the clinical trial reports of traditional Chinese medicines.
Carcinomatous Meningitis: It Does Not Have to Be a Death Sentence

Carcinomatous meningitis, specifically leptomeningeal metastases from solid tumors, has a dismal prognosis, with an overall median survival of 2 to 4 months. Lymphomatous meningitis has a better outlook, with a median survival of more than 6 months, but diagnosis may be delayed and treatment is not curative. Despite these poor statistics, there are subsets of patients who do relatively well. Moreover, there are a number of new approaches to the diagnosis and treatment of leptomeningeal metastases that promise to extend life and prevent disability. These include molecular techniques of diagnosis, expanding the repertoire of drugs available for intrathecal administration, using systemic chemotherapy to treat leptomeningeal disease, and applying strategies such as gene therapy and immunotoxins to the management of leptomeningeal metastases. These novel approaches offer the hope of liberating patients from a death sentence and providing clinicians with effective weapons in the fight against a dreaded neurologic complication of systemic cancer.
N-Heterocyclic Carbene–Gold(I) Complexes Conjugated to a Leukemia-Specific DNA Aptamer for Targeted Drug Delivery

This report describes the synthesis and characterization of novel N-heterocyclic carbene (NHC)-gold(I) complexes and their bioconjugation to the CCRF-CEM-leukemia-specific aptamer sgc8c. Successful bioconjugation was confirmed by the use of fluorescent tags on both the NHC-Au(I) complex and the aptamer. Cell-viability assays indicated that the NHC-Au(I) -aptamer conjugate was more cytotoxic than the NHC-gold complex alone. A combination of flow cytometry, confocal microscopy, and cell-viability assays provided clear evidence that the NHC-Au(I) -aptamer conjugate was selective for targeted CCRF-CEM leukemia cells.
SU-F-T-180: Evaluation of a Scintillating Screen Detector for Proton Beam QA and Acceptance Testing

Purpose: To test the performance of a commercial scintillating screen detector for acceptance testing and Quality Assurance of a proton pencil beam scanning system. Method: The detector (Lexitek DRD 400) has 40cm × 40cm field, uses a thin scintillator imaged onto a 16-bit scientific CCD with ∼0.5mm resolution. A grid target and LED illuminators are provided for spatial calibration and relative gain correction. The detector mounts to the nozzle with micron precision. Tools are provided for image processing and analysis of single or multiple Gaussian spots. Results: The bias and gain of the detector were studied to measure repeatability and accuracy. Gain measurements were taken with the LED illuminators to measure repeatability and variation of the lens-CCD pair as a function with f-stop. Overall system gain was measured with a passive scattering (broad) beam whose shape is calibrated with EDR film placed in front of the scintillator. To create a large uniform field, overlapping small fields were recorded with the detector translated laterally and stitched together to cover the full field. Due to the long exposures required to obtain multiple spills of the synchrotron and very high detector sensitivity, borated polyethylene shielding was added to reduce direct radiation events hitting the CCD. Measurements with a micro ion chamber were compared to the detector's spot profile. Software was developed to process arrays of Gaussian spots and to correct for radiation events. Conclusion: The detector background has a fixed bias, a small component linear in time, and is easily corrected. The gain correction method was validated with 2% accuracy. The detector spot profile matches the micro ion chamber data over 4 orders of magnitude. The multiple spot analyses can be easily used with plan data for measuring pencil beam uniformity and for regular QA comparison.
Regional Development: Special Economic Zones

In 1979 Deng Xiaoping opened China to closer economic contacts with the world. This opening was the beginning of China’s economic integration with other nations, and required parallel actions on the political side in the form of improved intergovernmental relations between China and other nations. Beginning in 1979 China adopted a policy of improving commercial and investment relationships with its trading partners, including neighboring countries and the western industrial nations.
The Pharmacology of Estrogens in Osteoporosis

Publisher Summary This chapter focuses on the pharmacological utility of estrogens in treating osteoporosis. Control of bone remodeling is intimately linked to estrogen status in the human female and perhaps in the human male. Consequently, loss of estrogen production by the ovary, which occurs in all women at menopause, is associated with increased activation of remodeling and an alteration in the equilibrium between bone resorption and formation. When estrogens are administered to estrogen-deficient women, there is a reduction in bone remodeling that can be monitored biochemically. During the initial weeks of therapy, there is a gradual decline in biochemical resorption of pyridinoline cross-linking molecules. There is also a similar but more delayed decline in biochemical measures of bone formation, such as osteocalcin and bone-specific alkaline phosphatase. The timing of these biochemical changes is presumed to represent an initial rapid reduction in activation of new remodeling sites. When estrogen therapy is discontinued, there is an immediate increase in bone remodeling that is reminiscent of ovariectomy. Numerous epidemiological studies have shown that estrogen exposure is associated with a reduction in the risk of fractures of the hip and wrist. Controlled clinical trial data suggest a reduction of 50%–80% in the risk of vertebral fractures, when estrogens are used for prevention, or treatment. Estrogens reduce urinary calcium loss and, at the renal level, cause an increase PTH activity. Estrogens, however, increase skeletal resistance to the resorptive stimulatory effects of PTH without appearing to interfere with the anabolic effects of PTH. Estrogens also stimulate intestinal absorption of calcium, perhaps directly or by modulating the effects of PTH on the renal 1 α-hydroxylase, thereby increasing the supply of 1,25-dihydroxyvitamin D.
The Residential Quarter in Bukhara before the Revolution (The Work of O. A. Sukhareva)

Soviet Scholarship on Islamic studies exists in almost hermetic isolation from its Western counterpart for both linguistic and methodological reasons. Soviet scholarship is concerned with a different set of questions that emerge from Soviet Marxism, rarely tackling the conceptual questions formulated in the West. Nevertheless, Soviet scholarship is very strong on descriptive detail which could, if properly utilized, enrich Western debate. Unfortunately, few Western Islamicists (except those involved in Central Asian history) know Russian, and therefore a wealth of factual information unearthed by Soviet scholars remains virtually unknown in the West and plays no part in the scholarly discourse here.
Teaching Helping Skills Courses: Creative Activities to Reduce Anxiety

ABSTRACTHelping skills courses play a vital role in counseling curriculum, but also tend to bring excessive anxiety for students, to the point of impeding their ability to successfully implement skills. This article describes specific creative and experiential activities, aimed at reducing anxiety in a helping skills course for counselors-in-training.
GPU Performance Estimation using Software Rasterization and Machine Learning

This paper introduces a predictive modeling framework to estimate the performance of GPUs during pre-silicon design. Early-stage performance prediction is useful when simulation times impede development by rendering driver performance validation, API conformance testing and design space explorations infeasible. Our approach builds a Random Forest regression model to analyze DirectX 3D workload behavior when executed by a software rasterizer, which we have extended with a workload characterizer to collect further performance information via program counters. In addition to regression models, this work produces detailed feature rankings which can provide valuable architectural insight, and accurate performance estimates for an Intel integrated Skylake generation GPU. Our models achieve reasonable out-of-sample-error rates of 14%, with an average simulation speedup of 327x.
Compatibility studies on Mo–coating systems for nuclear fuel cladding applications

Abstract To improve the safety factor of nuclear power plants in accident scenarios, molybdenum (Mo), with its high-temperature strength, is proposed as a potential fuel-cladding candidate. However, Mo undergoes rapid oxidation and sublimation at elevated temperatures in oxygen-rich environments. Thus, it is necessary to coat Mo with a protective layer. The diffusional interactions in two systems, namely, Zircaloy-2 (Zr2) on a Mo tube, and iron-chromium-aluminum (FeCrAl) on a Mo rod, were studied by aging coated Mo substrates in high vacuum at temperatures ranging from 650 °C to 1000° for 1000 h. The specimens were characterized using scanning electron microscopy (SEM), energy-dispersive spectrometry (EDS) and nanoindentation. In both systems, pores in the coating increased in size and number with increasing temperature over time, and cracks were also observed; intermetallic phases formed between the Mo and its coatings.
Usability, content, and connections: How county-level Alabama emergency management agencies communicate with their online public

Abstract Emergency Management Agencies (EMAs) in the U.S. operate at federal, state, and local levels, each with a common purpose “to prepare for, prevent, respond to, recover from, and mitigate the effects of incidents” (Homeland Security, 2008). As Homeland Security (2008) explains, local EMAs (LEMAs) lay the groundwork for prevention and other activities, coordinating with nearby LEMAs and local entities, including private and non-governmental organizations. LEMAs have been studied little; most research on online LEMAs and State Emergency Management Agencies (SEMAs) has been limited to website content, providing an incomplete picture of how they provide online service to the public. Bertot & Jager argue that functionality, usability, and accessibility are critical elements in evaluating e-government, noting that if users cannot get to or find the content, the content becomes irrelevant. This study contributes to addressing this gap by evaluating Alabama LEMA websites, based on a combination of content rubrics used in prior EMA studies and usability heuristics, factors that can affect user trust, and thus a site's usefulness. It also looks at how Alabama LEMAs are using social networking on their websites.
Data and Calibration Challenges for Spill Response Models

AbstractAccurate predictions of time of travel and concentration of the plume are critical for decision makers to respond to a spill. A quick response to an incident requires availability of data i...
Endometrial Adenocarcinoma With Pulmonary Recurrence.

We present the case of an 83-year-old woman with a history of grade 1 stage IB endometrial cancer (endometrial adenocarcinoma) (figure 1) involving the lower uterine segment. She underwent robotic hysterectomy with right salpingo-oophorectomy followed by brachytherapy. A year and a half later, she presented with difficulty in breathing. A chest X-ray showed 8 mm nodular density in the right lower lobe. The above finding was confirmed with CT. Given the concern for a malignant lesion, positron emission tomography/CT scan was performed, which revealed two metabolically active lung nodules, measuring 1.2 cm in …
Materia Est Valde Periculosa: Interpreting Testaments in Quattrocento Florence

In one of his many consilia concerning a testament, the noted Sienese jurist Bartolomeo Sozzini declared the matter before him dangerous (periculosa). The testament before him had in fact established a line of succession in trust (fideicommissum) through a daughter, in the absence of sons. That was a relatively unusual situation, but not so much so that a solution could not be found. A comparison with some other consilia shows that the danger in this case arose in interpreting the intent of the testator from amidst the uncertain terms employed in the text of the testament, coupled with the lack of a line of direct agnatic descent (such that the meaning of the term familia became uncertain, for example). A disinheritance in a line of agnatic descent further muddied the waters, though Sozzini was intent on reestablishing the claims of that line. Above all, there was the danger that Sozzini might not be able to muster sufficient authoritative references to bolster his opinion and persuade the court.
Identification of targeting peptides for the diagnosis of myocarditis.

AIM Current diagnostic tests for myocarditis are invasive and have low diagnostic value. Our aim was to identify potential targeting peptides to detect early myocarditis following intravenous delivery. MATERIALS & METHODS We used an animal model of experimental autoimmune myocarditis and a phage display library to identify potential targeting peptides. After several steps, we selected two peptides, MyH-PhD-05 and MyH-PhD-120, for in vivo screening using fluorescent imaging. Immunofluorescence and proteonomic analysis was used to identify potential cellular and molecular targets of MyH-PhD-05. Echocardiography was used to assess functional changes. RESULTS Peptide MyH-PhD-05 was able to detect animals with severe myocarditis even in the absence of functional changes. Immunofluorescence demonstrated that MyH-PhD-05 colocalizes with CD4+ T cells and monocytes (CD11b+) in cardiac infiltrates. CONCLUSION We identified potential targeting peptides for the diagnosis of myocarditis. Future studies will focus on better identification of potential targets and translating this technology to clinically relevant imaging modalities.
Analysing Orientations in Policy

The orientations framework can be applied by researchers to analysis of many different types of education policy. When applying this framework, it is important to note that orientations should not be treated in a simplistic manner. The way an orientation manifests may change over time or across discourses. For example, in discussion of sex education discourses, Irvine (2002) discusses two key conservative sex education policy approaches: a censoring non-approach wherein ‘initiatives to protect children from exposure to allegedly corrupting sex talk, whether from sex education programs or the media, are central’ (p. 1) and a morality-based sex education approach where:
Allele phasing has minimal impact on phylogenetic reconstruction from targeted nuclear gene sequences in a case study of Artocarpus.

PREMISE OF THE STUDY Untapped information about allele diversity within populations and individuals (i.e., heterozygosity) could improve phylogenetic resolution and accuracy. Many phylogenetic reconstructions ignore heterozygosity because it is difficult to assemble allele sequences and combine allele data across unlinked loci, and it is unclear how reconstruction methods accommodate variable sequences. We review the common methods of including heterozygosity in phylogenetic studies and present a novel method for assembling allele sequences from target-enriched Illumina sequencing libraries. METHODS We performed supermatrix phylogeny reconstruction and species tree estimation of Artocarpus based on three methods of accounting for heterozygous sequences: a consensus method based on de novo sequence assembly, the use of ambiguity characters, and a novel method for incorporating read information to phase alleles. We characterize the extent to which highly heterozygous sequences impeded phylogeny reconstruction and determine whether the use of allele sequences improves phylogenetic resolution or decreases topological uncertainty. KEY RESULTS We show here that it is possible to infer phased alleles from target-enriched Illumina libraries. We find that highly heterozygous sequences do not contribute disproportionately to poor phylogenetic resolution and that the use of allele sequences for phylogeny reconstruction does not have a clear effect on phylogenetic resolution or topological consistency. CONCLUSIONS We provide a framework for inferring phased alleles from target enrichment data and for assessing the contribution of allelic diversity to phylogenetic reconstruction. In our data set, the impact of allele phasing on phylogeny is minimal compared to the impact of using phylogenetic reconstruction methods that account for gene tree incongruence.
Time to surgery in colon cancer: Predictors and association with survival—An analysis of the National Cancer Database (NCDB).

599Background: Time-to-surgery (TTS) refers to the wait time from the diagnosis of cancer to surgical resection of the primary tumor. In breast and bladder cancers, longer TTS has been shown to be ...
Functional Brain Alterations Associated With Cognitive Control in Blast-Related Mild Traumatic Brain Injury.

Objectives: Research on the cognitive sequelae of mild traumatic brain injury (mTBI) suggests that, despite generally rapid recovery, difficulties may persist in the domain of cognitive control. The goal of this study was to examine whether individuals with chronic blast-related mTBI show behavioral or neural alterations associated with cognitive control. Methods: We collected event-related functional magnetic resonance imaging (fMRI) data during a flanker task in 17 individuals with blast-related mTBI and 16 individuals with blast-exposure without TBI (control). Results: Groups did not significantly differ in behavioral measures of cognitive control. Relative to the control group, the mTBI group showed greater deactivation of regions associated with the default mode network during the processing of errors. Additionally, error processing in the mTBI group was associated with enhanced negative coupling between the default mode network and the dorsal anterior cingulate cortex as well as the dorsolateral prefrontal cortex, regions of the salience and central executive networks that are associated with cognitive control. Conclusions: These results suggest that deactivation of default mode network regions and associated enhancements of connectivity with cognitive control regions may act as a compensatory mechanism for successful cognitive control task performance in mTBI. (JINS, 2018, 24, 1–11)
Preference Separability and Value Functions

In typical non-trivial multiple-criteria decision problems, the decision makers are faced with the ordering problems over a number of possible outcomes with a number of attributes. One of the human great inventions is the numerical system. If we could use the numerical systems for ordering so that the more preferred outcome will have a higher numerical value, then the decision making problem would become much easier. Unfortunately, this approach is not an easy one. A number of assumptions are needed for us to attach numerical ordering for the preference over the outcomes. (See [1-7], [10])
Differentiation of Seed, Sugar, and Biomass-Producing Genotypes in Saccharinae Species

Plant sinks including grain, stem sugar, leaf, and stem biomass as well as roots and rhizomes are the primary Saccharinae products of interest to humans. While plants evolved particular ratios of these sinks in the wild, humans have selected for altered ratios to fit production needs. Through further selection, specialty cultivars have recently been developed to maximize grain, sugar, biomass, or rhizome production as well as specialty carbohydrate and nutrient compositions. In sorghum and other C4 grass crops these specialized cultivars continue to undergo differentiation and could become, to some extent, genetically isolated populations. There has been limited research on the genetics and diversity of morphologically different crop ideotypes but it appears that inadequate recombination and selection has occurred to genetically isolate such genotypes yet. Importantly, recent results have shown that genetic tradeoffs among these various plant products may be avoidable, because photosynthesis is often sink, rather than source, limited. By combining and selecting multiple product types as optimized in specialty cultivars, harvestable products and energy may be further increased. Here, I review molecular genetic and phenotypic evidence of ideotype differentiation and discuss how harvestable energy might be maximized by carefully selecting for multiple products. There are a wide range of potential confounding factors, such as flowering time, that may alter conclusions and some possible solutions are suggested. If an ultimate goal is maximum usable energy production per unit area to satisfy growing global demand for food, fiber, fuel, and land, then breeding for only single products may sacrifice potential productivity.
RATE OF GRAPHITIZATION OF CARBON

The rate of graphitization was studied on molded carbon specimens composed mainly of petroleum coke by measuring the changes occurring with time in the electric and thermal conductivities and in the crystallite size at various graphitization temperatures. The results yield a distribution of activation energies for the crystallite growth in the temperature range studied extending from about 80 kcal to 210 kcal/mole and having two peaks at about 100 and 200 kcal/mole. The first peak is associated probably with the healing of the disordered lattice, while the second one with the grain boundary displacements.
Thermotoga neapolitana adenylate kinase is highly active at 30°c

The adenylate kinase (AK) gene from Thermotoga neapolitana, a hyperthermophilic bacterium, was cloned and overexpressed in Escherichia coli, and the recombinant enzyme was biochemically characterized. The T. neapolitana AK (TNAK) sequence indicates that this enzyme belongs to the long bacterial AKs. TNAK contains the four cysteine residues that bind Zn(2+) in all Gram-positive AKs and in a few other Zn(2+)-containing bacterial AKs. Atomic emission spectroscopy and titration data indicate a content of 1 mol of Zn(2+)/mol of recombinant TNAK. The EDTA-treated enzyme has a melting temperature (T (m)=93.5 degrees C) 6.2 degrees C below that of the holoenzyme (99.7 degrees C), identifying Zn(2+) as a stabilizing feature in TNAK. TNAK is a monomeric enzyme with a molecular mass of approx. 25 kDa. TNAK displays V (max) and K (m) values at 30 degrees C identical with those of the E. coli AK at 30 degrees C, and displays very high activity at 80 degrees C, with a specific activity above 8000 units/mg. The unusually high activity of TNAK at 30 degrees C makes it an interesting model to test the role of enzyme flexibility in activity.
Mio Cid’s Powerful Gaze: The Subduing of the Lion in the Cantar de Mio Cid

This study seeks to broaden the understanding of the lion scene in Cantar de Mio Cid by exploring the visual interaction between Mio Cid and the lion. Given the importance the poet gives to optical imagery throughout the Cantar, vision and the gaze play a preponderant role in Mio Cid’s courageous subduing of the lion after the wild beast escapes from its cage. This study argues that Mio Cid is able to defuse the fierceness of the lion through the power of his gaze. As soon as the lion looks into the hero’s eyes, the beast is overwhelmed by the optical species emanating from them because these species convey the courage and inner worth immanent in Mio Cid’s soul. Thanks to textual evidence and theories of vision extant during the Middle Ages, this paper shows how humans were able to control and dominate both men and beasts through their gaze, and the lion is an apposite example of the power of human beings to exert their visual power upon others.
Disability Self-Identification and Well-Being in Emerging Adults:

Research suggests that emerging adults (EAs) with a disabling impairment experience poor psychosocial outcomes and delayed markers of adulthood. Given the numbers of EA with a disabling impairment ...
Recurrent Chylothorax in Renal Cell Carcinoma.

Chylothorax is a type of pleural effusion that results from the build up of chyle in the pleural space. Trauma and malignancies are its leading causes. Among malignancies, lymphomas cause the majority of chylothoraces. A few cases of chylothorax resulting from various solid malignancies have been reported in the literature but renal cell carcinoma (RCC) has been rarely associated. Here, we report a rare case of a unilateral chylothorax associated with a newly diagnosed RCC.
Ocular Manifestations of von Hippel-Lindau Disease

In this review article, we aimed to analyze the available data on the ocular manifestations of von Hippel-Lindau (VHL) disease. In this disease, the VHL protein becomes inactivated by germline mutations of the VHL tumor suppressor gene on chromosome 3p25-26, resulting in an overproduction of VEGF in non-hypoxic conditions. Ocular manifestations are expected in roughly half of VHL patients. Retinal capillary hemangioblastomas (RCHs) are the most commonly observed tumors in VHL and are often the initial manifestation of the disease. Ablative therapy, surgical resection, and pharmacotherapy have been implemented to control tumors. Left untreated, RCHs will often enlarge, emphasizing the importance of early diagnosis and treatment to preserve vision. Complications of enlarging peripheral or optic nerve tumors may be severe. Large RCHs may disrupt normal retinal architecture, eventually leading to exudative retinal detachment. Rarely, non-retinal manifestations, such as neovascularization of the iris or cornea, may progress to neovascular glaucoma and vision loss. Ablative therapy of larger tumors carries increasing risks and offers limited success, often necessitating surgical resection. Because this life-threatening disease is not routinely encountered in clinical practice, clinicians will benefit from our review which brings awareness to the ocular presentation of VHL and lifelong screening recommendations for diagnosed patients.
Abstract P1107: Acute Psychosocial Stress Increases Circulating Inflammatory Mediators in the Humanized Sickle Cell Mouse Model

Vaso-occlusive crisis often occurs in sickle cell disease (SCD). Since psychosocial stress leads to impaired vascular function and inflammation, we hypothesized that acute psychosocial stress elici...
ARIMA Model for Forecasting of Greengram Prices in Telangana by using SAS

Autoregressive integrated moving average (ARIMA) approach has been applied for modeling and forecasting of greengram prices in Telangana. Autocorrelation (AC) and partial autocorrelation (PAC) functions were estimated, which led to the identification and construction of ARIMA models, suitable in explaining the time series and forecasting the future production. To this end, evaluation of forecasting is carried out with Akaike’s information criterion (AIC) and Schwarz’s Bayesian information criterion ( BIC). The best identified model for the data under consideration was used for out-of-sample forecasting upto November 2019.
Resistin concentrations in serum and stifle synovial fluid from normal and cruciate deficient dogs with osteoarthritis.

Objective To compare synovial fluid (SF) resistin concentrations in healthy dogs to dogs with osteoarthritis (OA) secondary to cranial cruciate ligament (CrCL) injury and to correlate resistin concentrations with body condition score (BCS) and evaluate resistin release from peripheral blood mononuclear cells (PBMC) and adipocytes. Study design Controlled, prospective, clinical study ANIMALS: Thirty-nine client-owned dogs, 13 healthy and 26 with secondary OA, were enrolled. Blood was collected from six healthy purpose-bred dogs for PBMC culture. An additional six mixed-breed dogs were used for adipocyte collection and culture. Methods Resistin concentrations were measured with a canine-specific enzyme-linked immunoabsorbent assay. Resistin was compared between healthy SF and OA SF with Student's t test. Correlation of resistin concentrations to BCS was performed. Peripheral blood mononuclear cells and adipocytes were cultured under three conditions: negative control, lipopolysaccharide, and concanavalin A (Con A). A linear mixed model was used to determine differences in resistin concentrations among treatments. Results Resistin concentrations in OA SF were comparable to healthy SF. Neither serum nor SF resistin was correlated with BCS. Cultured PBMC stimulated with Con A released resistin, while adipocytes did not. Conclusion Neither serum nor SF resistin were altered in dogs with OA secondary to CrCL insufficiency. In addition, resistin was not correlated with canine body fat and did not appear to function as adipocytokine in the dog. Clinical significance Resistin may not be involved in the pathogenesis of OA. However, resistin may be important in inflammation because it is released from inflammatory cells.
Fault Diagnosis Based on Sparse Semi-supervised GAN Model

In this paper we propose a new fault diagnosis model based on sparse semi-supervised GAN (SSGAN).The SSGAN-based fault diagnosis can use a large amount of unmarked data to improve the accuracy of the marked training part.Solved the problem that the general neural network requires a large amount of tag data.In particular, we improved the discriminator to get a more sparse network, which further improved the classification effect.At the same time we choose Leaky ReLU as the activation function which solve the problem that the ReLU activation function has a dead zone.Simulation studies on the Tennessee–Eastman (TE) benchmark process evaluate the performance of the developed method, which indicate that the SSGAN method performs better than BPNN.
Youth safety perceptions of weight control behaviors: A moderated mediation study.

Abstract Background Youth may engage in healthy weight control behaviors (HWCBs) and unhealthy weight control behaviors (UWCBs) to lose or maintain weight. Youth observation of WCBs by supporter groups (parents/siblings/peers) and youth beliefs about the safety of WCBs may impact which WCBs youth use. The primary aim of this study was to examine the mediating role of youth safety perceptions of WCBs on the relationships between supporter group engagement in WCBs and youth engagement in WCBs. Youth BMI-z-score was analyzed as a moderator. Methods Participants were 219 youth (52.1% females), ages 10–17, attending an outpatient medical appointment. Participants completed questionnaires about their WCB use, whether they perceived WCBs as safe/unsafe, and whether they perceived parents, siblings and peers to use WCBs. A standardized formula including youth age, sex, height, and weight was used to calculate BMI-z-score. Results A moderated mediation model examining parental and youth engagement in UWCBs revealed that for youth in the healthy to overweight/obese (OV/OB) range, greater safety perception of UWCBs mediated the relationship between higher parent engagement in UWCBs and higher youth engagement in UWCBs. Furthermore, youth safety perception of HWCBs mediated the relationship between perceived parent, sibling, and peer engagement in HWCBs and youth engagement in HWCBs. Conclusion This study identifies perceived parent, sibling, and peer WCBs and youth safety perceptions as mechanisms affecting youth WCB engagement, particularly for youth in the OV/OB range. Intervention effectiveness may increase if parent, sibling, and peer WCBs are targeted and education about safe/unsafe ways to control weight is provided.
Design Optimization of Linear-Arm Flexure Bearings

Flexure bearings have been used in linear-resonant compressors to maintain a non-contacting clearance seal between the piston and cylinder. This paper examines the linear-arm flexure bearing which was recently introduced. Linear-arm flexures have a higher radial stiffness and a higher radial-to-axial stiffness ratio than the spiral-arm flexures which are commonly used. Finite element analysis was used to study a wide range of linear-arm flexure sizes and materials. From this modeling, design graphs have been developed to assist in early compressor design stages and to provide the initial geometry for a more detailed finite element analysis. For a given stroke, diameter, stress, and Young’s modulus, the optimized material thickness and flexure arm geometry can be determined to maximize the radial stiffness. The radial stiffness, radial-to-axial stiffness ratio, and axial rotation can then be closely approximated from the design graphs presented here. A range of stroke-to-diameter ratios up to 0.2 was analyzed. A linear-arm flexure bearing was fabricated, and the measured stiffness agreed with that calculated by the finite element model to within 12%.
A set of orbital elements to fully represent the zonal harmonics around an oblate celestial body

This work introduces a new set of orbital elements to fully represent the zonal harmonics problem around an oblate celestial body. This new set of orbital elements allows to obtain a complete linear system for the unperturbed problem and, in addition, a complete polynomial system when considering the perturbation produced by the zonal harmonics from the gravitational force of an oblate celestial body. These orbital elements present no singularities and are able to represent any kind of orbit, including elliptic, parabolic and hyperbolic orbits. In addition, an application to this formulation of the Poincare-Lindstedt perturbation method is included to obtain an approximate first order solution of the problem for the case of the J2 perturbation.
International Consensus Guidance for Management of Myasthenia Gravis: 2020 Update

Objective To update the 2016 formal consensus-based guidance for the management of myasthenia gravis (MG) based on the latest evidence in the literature. Methods In October 2013, the Myasthenia Gravis Foundation of America appointed a Task Force to develop treatment guidance for MG, and a panel of 15 international experts was convened. The RAND/UCLA appropriateness method was used to develop consensus recommendations pertaining to 7 treatment topics. In February 2019, the international panel was reconvened with the addition of one member to represent South America. All previous recommendations were reviewed for currency, and new consensus recommendations were developed on topics that required inclusion or updates based on the recent literature. Up to 3 rounds of anonymous e-mail votes were used to reach consensus, with modifications to recommendations between rounds based on the panel input. A simple majority vote (80% of panel members voting “yes”) was used to approve minor changes in grammar and syntax to improve clarity. Results The previous recommendations for thymectomy were updated. New recommendations were developed for the use of rituximab, eculizumab, and methotrexate as well as for the following topics: early immunosuppression in ocular MG and MG associated with immune checkpoint inhibitor treatment. Conclusion This updated formal consensus guidance of international MG experts, based on new evidence, provides recommendations to clinicians caring for patients with MG worldwide.
Extending methods: using Bourdieu's field analysis to further investigate taste

In this commentary on Per Anderhag, Per-Olof Wickman and Karim Hamza’s article Signs of taste for science, I consider how their study is situated within the concern for the role of science education in the social and cultural production of inequality. Their article provides a finely detailed methodology for analyzing the constitution of taste within science education classrooms. Nevertheless, because the authors’ socially situated methodology draws upon Bourdieu’s theories, it seems equally important to extend these methods to consider how and why students make particular distinctions within a relational context—a key aspect of Bourdieu’s theory of cultural production. By situating the constitution of taste within Bourdieu’s field analysis, researchers can explore the ways in which students’ tastes and social positionings are established and transformed through time, space, place, and their ability to navigate the field. I describe the process of field analysis in relation to the authors’ paper and suggest that combining the authors’ methods with a field analysis can provide a strong methodological and analytical framework in which theory and methods combine to create a detailed understanding of students’ interest in relation to their context.
The Role of Magnetic Helicity in Coronal Heating

One of the greatest challenges in solar physics is understanding the heating of the Sun's corona. Most theories for coronal heating postulate that free energy in the form of magnetic twist/stress is injected by the photosphere into the corona where the free energy is converted into heat either through reconnection or wave dissipation. The magnetic helicity associated with the twist/stress, however, is expected to be conserved and appear in the corona. In previous works, we showed that the helicity associated with the small-scale twists undergoes an inverse cascade via stochastic reconnection in the corona and ends up as the observed large-scale shear of filament channels. Our "helicity condensation" model accounts for both the formation of filament channels and the observed smooth, laminar structure of coronal loops. In this paper, we demonstrate, using helicity- and energy-conserving numerical simulations of a coronal system driven by photospheric motions, that the model also provides a natural mechanism for heating the corona. We show that the heat generated by the reconnection responsible for the helicity condensation process is sufficient to account for the observed coronal heating. We study the role that helicity injection plays in determining coronal heating and find that, crucially, the heating rate is only weakly dependent on the net helicity preference of the photospheric driving. Our calculations demonstrate that motions with 100% helicity preference are least efficient at heating the corona; those with 0% preference are most efficient. We discuss the physical origins of this result and its implications for the observed corona.
Designing thermal annealing to control mechanical performance of thermoplastic polyurethane elastomers

Abstract The use of thermoplastic polyurethane (TPU) films as a lightweight elastomer has grown continuously over the years due to their good mechanical properties and excellent chemical and corrosion resistance. Yet, the high-temperature mechanical performance of TPU elastomers needs to be improved for extending their application as metal counterparts. In this study, we design a facile post-processing thermal treatment (i.e. annealing) to control the mechanical performance of TPU films under a possible temperature rise during operation. For this purpose, the TPU films, prepared by compression molding of commercially available TPU granules, are annealed at different temperatures (i.e., 60, 120, and 180 °C) and times (i.e., 24 h and 1 week). The results reveal the effectiveness of annealing to enhance the creep behavior and storage modulus at high temperatures. In the meantime, the room temperature tensile properties of annealed samples remain almost unchanged, offering unique applications for the TPU elastomers often used at room temperature, while they may face a temperature increase up to a certain value during operation. The dual effect of annealing on structural evolution of TPUs (i.e., formation of new crystallites and slight rearrangement of hard segment rich domains) are also discussed through differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), small angle X-ray scattering (SAXS) characterizations, and atomic force microscopy (AFM).
Increasing Capacity in Disordered Rocksalt Cathodes by Mg Doping

Author(s): Zhong, P; Cai, Z; Zhang, Y; Giovine, R; Ouyang, B; Zeng, G; Chen, Y; Clement, R; Lun, Z; Ceder, G | Abstract: Using both computations and experiments, we demonstrate that the performance of Li-excess cation-disordered rocksalt cathodes can be improved by Mg substitution. Mg reduces the amount of Li in the compound that is strongly bound to F and thereby increases the capacity. This enables the use of fluorination as a tool to improve stability of the compounds without significant loss of capacity. Mg emerged as the most optimal substitution element from a systematic computational study aimed at identifying inactive doping elements with a strong enough bonding strength to fluorine to displace Li from the F environments. Our results also show that capacity can be traded for cycle life depending on whether Mg is substituted for Li or for the redox metal. This design strategy should be considered in fluorinated cathodes, which will facilitate the design of optimized disordered rocksalt oxyfluoride cathodes.
A solution in search of problems: a cognitive tool for solution mapping to promote divergent thinking

Engineering design processes are often defined as beginning with a problem and diverging to generate possible solutions; however, design processes can start with a newly developed technological sol...