cssi/SciSciGPT-SciSciNet huggingface dataset:
Understanding overconfidence: Theories of intelligence, preferential attention, and distorted self-assessment

Abstract Knowing what we don't yet know is critical for learning. Nonetheless, people typically overestimate their prowess—but is this true of everyone? Three studies examined who shows overconfidence and why. Study 1 demonstrated that participants with an entity (fixed) theory of intelligence, those known to avoid negative information, showed significantly more overconfidence than those with more incremental (malleable) theories. In Study 2, participants who were taught an entity theory of intelligence allocated less attention to difficult problems than those taught an incremental theory. Participants in this entity condition also displayed more overconfidence than those in the incremental condition, and this difference in overconfidence was mediated by the observed bias in attention to difficult problems. Finally, in Study 3, directing participants' attention to difficult aspects of the task reduced the overconfidence of those with more entity views of intelligence. Implications for reducing biased self-assessments that can interfere with learning were discussed.
The Socioeconomic Consequences of Teen Childbearing Reconsidered

We present new estimates of the consequences of teen childbearing that take into account observed and unobserved family background heterogeneity comparing sisters who have timed their first births at different ages....The estimation is conducted using data from the [U.S.] National Longitudinal Survey of Young Women.... (EXCERPT)
Failure mode analysis of the Endologix endograft

Objective Type III (T-III) endoleaks following endovascular aneurysm repair (EVAR) remain a major concern. Our center experienced a recent concentration of T-III endoleaks requiring elective and emergency treatment and prompted our review of all EVAR implants over a 40-month period from April 2011 until August 2014. This report represents a single center experience with T-III endoleak management with analysis of factors leading to the T-III-related failure of EVAR. Methods A retrospective review of all the operative reports, medical records, and computed tomography scans were reviewed from practice surveillance. Using Society for Vascular Surgery aneurysm reporting standards, we analyzed the morphology of the aneurysms before and after EVAR implant using computed tomography. Index procedure and frequency of reinterventions required to maintain aneurysm freedom from rupture were compared across all devices using SAS v 9.4 (SAS Institute, Inc, Cary, NC). Major adverse events (MAEs) requiring secondary interventions for aneurysm treatment beyond primary implant were analyzed for methods of failure. Aneurysm morphology of patients requiring EVAR was compared across all endograft devices used for repair. For purposes of MAE analysis, patients receiving Endologix (ELX) endograft were combined into group 1; Gore, Cook, and Medtronic endograft patients were placed into group 2. Results Overall, technical success and discharge survival were achieved in 97.3% and 98% of patients regardless of device usage. There was no significant device related difference identified between patient survival or freedom from intervention. MAEs involving aneurysm treatment were over seven-fold more frequent with ELX (group 1) vs non-ELX (group 2) endografts ( P P = .0038). Conclusions While EVAR technical success and survival were similar across all devices, ELX devices exhibited an unusually high incidence of T-III endoleaks when implanted in abdominal aortic aneurysms with a diameter of more than 65 mm. Frequent reinterventions were required for Endologix devices for prevention of aneurysm rupture due to T-III endoleaks.
Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection

ABSTRACT Herpesviruses must contend with host cell epigenetic silencing responses acting on their genomes upon entry into the host cell nucleus. In this study, we confirmed that unchromatinized herpes simplex virus 1 (HSV-1) genomes enter primary human foreskin fibroblasts and are rapidly subjected to assembly of nucleosomes and association with repressive heterochromatin modifications such as histone 3 (H3) lysine 9-trimethylation (H3K9me3) and lysine 27-trimethylation (H3K27me3) during the first 1 to 2 h postinfection. Kinetic analysis of the modulation of nucleosomes and heterochromatin modifications over the course of lytic infection demonstrates a progressive removal that coincided with initiation of viral gene expression. We obtained evidence for three phases of heterochromatin removal from an early gene promoter: an initial removal of histones and heterochromatin not dependent on ICP0, a second ICP0-dependent round of removal of H3K9me3 that is independent of viral DNA synthesis, and a third phase of H3K27me3 removal that is dependent on ICP0 and viral DNA synthesis. The presence of ICP0 in transfected cells is also sufficient to promote removal of histones and H3K9me3 modifications of cotransfected genes. Overall, these results show that ICP0 promotes histone removal, a reduction of H3K9me3 modifications, and a later indirect reduction of H3K27me3 modifications following viral early gene expression and DNA synthesis. Therefore, HSV ICP0 promotes the reversal of host epigenetic silencing mechanisms by several mechanisms. IMPORTANCE The human pathogen herpes simplex virus (HSV) has evolved multiple strategies to counteract host-mediated epigenetic silencing during productive infection. However, the mechanisms by which viral and cellular effectors contribute to these processes are not well defined. The results from this study demonstrate that HSV counteracts host epigenetic repression in a dynamic stepwise process to remove histone 3 (H3) and subsequently target specific heterochromatin modifications in two distinct waves. This provides the first evidence of a stepwise reversal of host epigenetic silencing by viral proteins. This work also suggests that targets capable of disrupting the kinetics of epigenetic regulation could serve as potential antiviral therapeutic agents.
Moral Hazard, Risks and Index Insurance in the Rural Credit Market: A Framed Field Experiment in China

Abstract This paper studies the interaction between index insurance market and the rural credit market by investigating how the availability of index insurance affects borrowers' moral hazard behavior. Among different types of moral hazard problem in the credit market, we focuses on credit diversion, which occurs when borrowers violate loan contracts and use some or all of production loans for consumption purpose. We build a theoretical model to show that credit non-diverters are likely to benefit from and purchase index insurance, while credit diverters are not. For credit non-diverters, index insurance provides consumption smoothing and increases future income by preventing loan default. For credit diverters who are already implicitly insured by diverting credit from risky investments to consumption, index insurance increases their consumption risks and can even lower expected consumption level. The fundamental reason for the difference of the impact between credit diverters and non-diverters is that index insurance pays indemnities based on external indices rather than farmers' realized outcome. Therefore, the availability of index insurance encourages farmers to choose full investment of loans instead of credit diversion. To test these theoretical predictions empirically, we conducted a framed field experiment with 450 rural households in the north region of China. Coinciding with theoretical predictions, experimental results show that index insurance reduces the number of credit diverters by 75.8%. The treatment effect on credit diversion is heterogeneous across farmers depending on their risk preferences and ethical costs associated with violating loan contracts. The theoretical and empirical results have important policy implications for stimulating credit supply to agriculture and reducing credit rationing. They suggest that lenders can use index insurance as a signaling instrument to overcome information asymmetry in the credit market. Index insurance can be substituted for collateral requirements and lessen both quantity and risk rationing caused by collateral requirement.
Party pledges in the news: Which election promises do the media report?

Focusing on Bulgaria, and covering the 1990–2009 period, this article analyses what factors predict if print media will report election promises made by political parties. The study utilizes two or...
Effects of a scalar scaling field on quantum mechanics

This paper describes the effects of a complex scalar scaling field on quantum mechanics. The field origin is an extension of the gauge freedom for basis choice in gauge theories to the underlying scalar field. The extension is based on the idea that the value of a number at one space time point does not determine the value at another point. This, combined with the description of mathematical systems as structures of different types, results in the presence of separate number fields and vector spaces as structures, at different space time locations. Complex number structures and vector spaces at each location are scaled by a complex space time dependent scaling factor. The effect of this scaling factor on several physical and geometric quantities has been described in other work. Here the emphasis is on quantum mechanics of one and two particles, their states and properties. Multiparticle states are also briefly described. The effect shows as a complex, nonunitary, scalar field connection on a fiber bundle description of nonrelativistic quantum mechanics. The lack of physical evidence for the presence of this field so far means that the coupling constant of this field to fermions is very small. It also means that the gradient of the field must be very small in a local region of cosmological space and time. Outside this region, there are no restrictions on the field gradient.
GEORG JELLINEK ON VALUES AND OBJECTIVITY IN THE LEGAL AND POLITICAL SCIENCES

Georg Jellinek was one of the legal theorists who brought a new level of methodological sophistication to German public law scholarship at the turn of the twentieth century. Where previous research has called attention to his theory of conceptual “types” and his application of contemporary neo-Kantian epistemology to the law, this article explores his thinking on the nature of values and value judgments, and the possibilities for objectivity in the legal and political sciences. Jellinek sought to open an increasingly calcified legal positivism to the findings of the social sciences and to an inherently pluralistic, changing world of subjective values, but without abandoning the positivist ideals of legal certainty and the exclusion of political and other value judgments. Analyzing his response to this challenge opens a window onto his broader work in public law and political science, illuminating doctrines like the “two-sided” theory of the state and the “normative power of the factual,” which have achieved a lasting place in German legal and political theory. It also shows why Jellinek put aside the traditional ideal of bias-free objectivity for a surprisingly modern vision of a process of intersubjective agreement, driven by the institutions of free and open scholarly debate.
Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women

OBJECTIVE To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses’ Health Study II. RESULTS The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14–1.58), 1.13 (0.97–1.31), 1.11 (0.95–1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1% ( P = 0.0007) of the association was mediated through prepregnancy BMI. CONCLUSIONS These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.
Bargaining and efficiency in networks

We study an innite horizon game in which pairs of players connected in a network are randomly matched to bargain over a unit surplus. Players who reach agreement are removed from the network without replacement. The global logic of ecient matchings and the local nature of bargaining, in combination with the irreversible exit of player pairs following agreements, create severe hurdles to the attainment of eciency in equilibrium. For many networks all Markov perfect equilibria of the bargaining game are inecient, even as players become patient. We investigate how incentives need to be structured in order to achieve eciency via subgame perfect, but non-Markovian, equilibria. The analysis
Asymptotic density, immunity and randomness

In 2012, inspired by developments in group theory and complexity, Jockusch and Schupp introduced generic com- putability, capturing the idea that an algorithm might work correctly except for a vanishing fraction of cases. However, we observe that their definition of a negligible set is not computably invariant (and thus not well-defined on the 1-degrees), resulting in some failures of intuition and a break with standard expectations in computability theory. To strengthen their approach, we introduce a new notion of intrinsic asymptotic density, with rich relations to both randomness and classical computability theory. We then apply these ideas to propose alternative foundations for further development in (intrinsic) generic computability. Toward these goals, we classify intrinsic density 0 as a new immunity property, specifying its position in the standard hierar- chy from immune to cohesive for both general and � 0 sets, and identify intrinsic density 1 as the stochasticity corresponding to permutation randomness. We also prove that Rice's Theorem extends to all intrinsic variations of generic computability, demon- strating in particular that no such notion considers ∅ � to be "computable".
Taking Control: Stealth Assessment of Deterministic Behaviors Within a Game-Based System

Game-based environments frequently afford students the opportunity to exert agency over their learning paths by making various choices within the environment. The combination of log data from these systems and dynamic methodologies may serve as a stealth means to assess how students behave (i.e., deterministic or random) within these learning environments. The current work captures variations in students’ behavior patterns by employing two dynamic analyses to classify students’ sequences of choices within an adaptive learning environment. Random Walk analyses and Hurst exponents were used to classify students’ interaction patterns as random or deterministic. Forty high school students interacted with the game-based system, iSTART-ME, for 11-sessions (pretest, 8 training sessions, posttest, and a delayed retention test). Analyses revealed that students who interacted in a more deterministic manner also generated higher quality self-explanations during training sessions. The results point toward the potential for dynamic analyses such as random walk analyses and Hurst exponents to provide stealth assessments of students’ learning behaviors while engaged within a game-based environment.
Orientation diffusions

Diffusions are useful for image processing and computer vision because they provide a convenient way of smoothing noisy data, analyzing images at multiple scales, and enhancing discontinuities. A number of diffusions of image brightness have been defined and studied so far; they may be applied to scalar and vector-valued quantities that are naturally associated with intervals of either the real line, or other flat manifolds. Some quantities of interest in computer vision, and other areas of engineering that deal with images, are defined on curved manifolds; typical examples are orientation and hue that are defined on the circle. Generalizing brightness diffusions to orientation is not straightforward, especially in the case where a discrete implementation is sought. An example of what may go wrong is presented. A method is proposed to define diffusions of orientation-like quantities. First a definition in the continuum is discussed, then a discrete orientation diffusion is proposed. The behavior of such diffusions is explored both analytically and experimentally. It is shown how such orientation diffusions contain a nonlinearity that is reminiscent of edge-process and anisotropic diffusion. A number of open questions are proposed.
Last Glacial Maximum and deglacial abyssal seawater oxygen isotopic ratios

Abstract. An earlier analysis of pore-water salinity (chlorinity) in two deep-sea cores, using terminal constraint methods of control theory, concluded that although a salinity amplification in the abyss was possible during the LGM, it was not required by the data. Here the same methodology is applied to δ18Ow in the upper 100 m of four deep-sea cores. An ice volume amplification to the isotopic ratio is, again, consistent with the data but not required by it. In particular, results are very sensitive, with conventional diffusion values, to the assumed initial conditions at −100 ky and a long list of noise (uncertainty) assumptions. If the calcite values of δ18O are fully reliable, then published enriched values of the ratio in seawater are necessary to preclude sub-freezing temperatures, but the seawater δ18O in pore fluids does not independently require the conclusion.
International law, temporalities and narratives of the climate crisis

This review essay reads four books that pertain directly or indirectly to the climate crisis. It foregrounds the different temporalising narratives that underpin these accounts and investigates how these enliven different possibilities for thinking about action and responsibility in the present.
Post-Selection Inference for Generalized Linear Models With Many Controls

This article considers generalized linear models in the presence of many controls. We lay out a general methodology to estimate an effect of interest based on the construction of an instrument that immunizes against model selection mistakes and apply it to the case of logistic binary choice model. More specifically we propose new methods for estimating and constructing confidence regions for a regression parameter of primary interest α0, a parameter in front of the regressor of interest, such as the treatment variable or a policy variable. These methods allow to estimate α0 at the root-n rate when the total number p of other regressors, called controls, potentially exceeds the sample size n using sparsity assumptions. The sparsity assumption means that there is a subset of s < n controls, which suffices to accurately approximate the nuisance part of the regression function. Importantly, the estimators and these resulting confidence regions are valid uniformly over s-sparse models satisfying s2log 2p = o(n...
Some Inequalities for Polynomials

(1960). Some Inequalities for Polynomials. The American Mathematical Monthly: Vol. 67, No. 9, pp. 847-851.
Anionic Polymerization of Isoprene: Effect of Ionic Character of the Growing Ion Pair on Polymer Structure

The styrene content of styrene-isoprene copolymers initiated by alkali metals in different solvents is correlated with the total 1,4-adduct content of isoprene homopolymers initiated in the same manner. A very good linear relationship is obtained over the whole range which is dependent on the ionic character of the propagating species highly ionic systems (i.e., Na in ethers) give high styrene and low 1,4-adduct contents, while less ionic systems, i.e., butyllithium in aromatic ethers and in hydrocarbons, give progressively lower styrene and higher 1,4-adduct contents.
Bromination of Olefins with HBr and DMSO

A simple and inexpensive methodology is reported for the conversion of alkenes to 1,2-dibromo alkanes via oxidative bromination using HBr paired with dimethyl sulfoxide, which serves as the oxidant as well as cosolvent. The substrate scope includes 21 olefins brominated in good to excellent yields. Three of six styrene derivatives yielded bromohydrins under the reaction conditions.
Dynamic Mechanical Properties of Stretched Natural Rubber

Dynamic shear compliance measurements on a vulcanized natural rubber stock have been carried out from 50 to 5000 cps as a function of static elongation in the range 0–400%. Above 300% elongation several very large resonance dispersions appear in the region 1000–2000 cps, but at lower elongations no such resonances are observed. The appearance of mechanical resonance dispersion thus coincides with the development of oriented crystallinity in the stretched rubber as shown from x‐ray diffraction data. On the other hand, the magnitudes of the dispersions decrease with increasing elongation above 300% whereas x‐ray measurements indicate the amount or extent of crystallinity increases with stretching above 300% elongation. The resonances thus clearly decrease as the crystallinity becomes more perfect or more extensive and hence appear to reflect the imperfections of the crystalline regions formed by elongation rather than the crystallinity itself. Observed changes in the compliance spectrum with time at each el...
Efficient Dynamic Provable Possession of Remote Data via Update Trees

The emergence and wide availability of remote storage service providers prompted work in the security community that allows clients to verify integrity and availability of the data that they outsourced to a not fully trusted remote storage server at a relatively low cost. Most recent solutions to this problem allow clients to read and update (i.e., insert, modify, or delete) stored data blocks while trying to lower the overhead associated with verifying the integrity of the stored data. In this work, we develop a novel scheme, performance of which favorably compares with the existing solutions. Our solution additionally enjoys a number of new features, such as a natural support for operations on ranges of blocks, revision control, and support for multiple user access to shared content. The performance guarantees that we achieve stem from a novel data structure called a balanced update tree and removing the need for interaction during update operations in addition to communicating the updates themselves.
Enantioselective synthesis of highly substituted furans by a copper(II)-catalyzed cycloisomerization-indole addition reaction.

A catalytic enantioselective reaction based on a copper(II) catalyst strictly containing chiral anionic ligands is described. In the present work, copper(II)–phosphate catalyst promotes the intramolecular heterocyclization of 2-(1-alkynyl)-2-alkene-1-ones and facilitates high levels of enantioselectivity in the subsequent nucleophile attack. Mechanistic studies suggest that formation of a copper(II)–indole species is important for catalysis.
ORBITAL DESIGN OF EARTH-ORIENTED TETHERED SATELLITE FORMATIONS

A formation of distributed sensors has great potential to enhance Earth surveillance. This paper investigates the dynamics of tethering several subsatellites together in a three-dimensional configuration. To keep the system oriented toward Earth, the Likins-Pringle rigid body equilibria are used as a baseline design. A flexible lumped-mass model is used to assess the stability of the tethered system. Three parameters related to the formation size, masses and spin rate are varied in order to find designs that demonstrate desirable dynamic behavior. While none of the designs are Lyapunov stable, formations with a spin axis near the local vertical are well-behaved over time spans of several orbits.
Oxidation of α-Trifluoromethyl Alcohols Using a Recyclable Oxoammonium Salt

A simple, mild method for the oxidation of α-trifluoromethyl alcohols to trifluoromethyl ketones (TFMKs) using the oxoammonium salt 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (1) is described. Under basic conditions, oxidation proceeds rapidly and affords good to excellent yields of TFMKs, without concomitant formation of the hydrate. The byproduct of the oxidation, 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinyloxy (1c), is easily recovered and can be conveniently reoxidized to regenerate the oxoammonium salt.
Molecular metal catalysts on supports: organometallic chemistry meets surface science.

ConspectusRecent advances in the synthesis and characterization of small, essentially molecular metal complexes and metal clusters on support surfaces have brought new insights to catalysis and point the way to systematic catalyst design. We summarize recent work unraveling effects of key design variables of site-isolated catalysts: the metal, metal nuclearity, support, and other ligands on the metals, also considering catalysts with separate, complementary functions on supports. The catalysts were synthesized with the goal of structural simplicity and uniformity to facilitate incisive characterization. Thus, they are essentially molecular species bonded to porous supports chosen for their high degree of uniformity; the supports are crystalline aluminosilicates (zeolites) and MgO. The catalytic species are synthesized in reactions of organometallic precursors with the support surfaces; the precursors include M(L)2(acetylacetonate)1–2, with M = Ru, Rh, Ir, or Au and the ligands L = C2H4, CO, or CH3. Os3(CO...
L1 to Mars: A Combined Robotic/Piloted Mars Mission

Mission scenarios for piloted Mars mission have traditionally consisted of a landing on Mars followed by a long stay time before the Earth–Mars planetary alignment would allow a minimum energy retu...
Layered Metal Sulfides Capture Uranium from Seawater

Uranium is the main source for nuclear energy but also one of the most toxic heavy metals. The current methods for uranium removal from water present limitations, such as narrow pH operating range, limited tolerance to high salt concentrations, or/and high cost. We show here that a layered sulfide ion exchanger K2MnSn2S6 (KMS-1) overcomes these limitations and is exceptionally capable in selectively and rapidly sequestering high (ppm) as well as trace (ppb) quantities of UO22+ under a variety of conditions, including seawater. KMS-1 can efficiently absorb the naturally occurring U traces in seawater samples. The results presented here reveal the exceptional potential of sulfide-based ion-exchangers for remediating of uranium-containing wastes and groundwater and for extracting uranium from the sea.
Enantioselective Homocrotylboration of Aliphatic Aldehydes

A practical route to optically pure syn-homocrotylation reagents is described, including highly diastereo- and enantioselective preparation of numerous syn-homocrotyl products, as well as several matched mismatched pairs. NMR experiments suggest that the active homocrotylating species is a cyclopropylcarbinyldichloroborane generated by chloride exchange from the PhBCl2 activator. Computational studies support the intermediacy of chloroboranes and suggest that homoallyl/homocrotyl transfers occur through Zimmerman–Traxler transition states.
Copper-catalyzed, directing group-assisted fluorination of arene and heteroarene C-H bonds.

We have developed a method for direct, copper-catalyzed, auxiliary-assisted fluorination of β-sp2 C–H bonds of benzoic acid derivatives and γ-sp2 C–H bonds of α,α-disubstituted benzylamine derivatives. The reaction employs a CuI catalyst, a AgF fluoride source, and DMF, pyridine, or DMPU solvent at moderately elevated temperatures. Selective mono- or difluorination can be achieved by simply changing reaction conditions. The method shows excellent functional group tolerance and provides a straightforward way for the preparation of ortho-fluorinated benzoic acids.
Architecture quality

During the past few years, researchers in Computer Architecture have seen a number of new, so called "non- von Neumann" innovations. Some of these innovations are finding their way into commercial computers, while others are relegated to the back waters of research logs. There are several reasons for the reluctance of manufacturers in implementing new ideas. One of the important reasons cited by the panel at NCC 81 [1] is the lack of quantitative data substantiating the benefits of the innovations. As one of the panelists remarked, "we need an order of magnitude improvements, hopefully in base 10", before new architectures can find their way into commercial computers.
Photoassisted Synthesis of Complex Molecular Architectures: Dearomatization of Benzenoid Arenes with Aza‐o‐xylylenes via an Unprecedented [2+4] Reaction Topology

A new method was developed for the photoinduced dearomatization of arenes through an intramolecular cycloaddition with aza-o-xylylenes generated by excited-state intramolecular proton transfer (ESIPT) in the readily available photoprecursors. The [2+4] topology of this cycloaddition is unprecedented for photo-dearomatizations of benzenoid aromatic carbocycles. It provides rapid access to novel heterocycles, cyclohexadieno-oxazolidino-quinolinols, as valuable synthons for a broad range of post-photochemical transformations.
Noncovalent Interactions in Organocatalysis and the Prospect of Computational Catalyst Design

ConspectusNoncovalent interactions are ubiquitous in organic systems, and can play decisive roles in the outcome of asymmetric organocatalytic reactions. Their prevalence, combined with the often subtle line separating favorable dispersion interactions from unfavorable steric interactions, often complicates the identification of the particular noncovalent interactions responsible for stereoselectivity. Ultimately, the stereoselectivity of most organocatalytic reactions hinges on the balance of both favorable and unfavorable noncovalent interactions in the stereocontrolling transition state (TS).In this Account, we provide an overview of our attempts to understand the role of noncovalent interactions in organocatalyzed reactions and to develop new computational tools for organocatalyst design. Following a brief discussion of noncovalent interactions involving aromatic rings and the associated challenges capturing these effects computationally, we summarize two examples of chiral phosphoric acid catalyzed r...
Text Mining for Drug–Drug Interaction

In order to understand the mechanisms of drug-drug interaction (DDI), the study of pharmacokinetics (PK), pharmacodynamics (PD), and pharmacogenetics (PG) data are significant. In recent years, drug PK parameters, drug interaction parameters, and PG data have been unevenly collected in different databases and published extensively in literature. Also the lack of an appropriate PK ontology and a well-annotated PK corpus, which provide the background knowledge and the criteria of determining DDI, respectively, lead to the difficulty of developing DDI text mining tools for PK data collection from the literature and data integration from multiple databases.To conquer the issues, we constructed a comprehensive pharmacokinetics ontology. It includes all aspects of in vitro pharmacokinetics experiments, in vivo pharmacokinetics studies, as well as drug metabolism and transportation enzymes. Using our pharmacokinetics ontology, a PK corpus was constructed to present four classes of pharmacokinetics abstracts: in vivo pharmacokinetics studies, in vivo pharmacogenetic studies, in vivo drug interaction studies, and in vitro drug interaction studies. A novel hierarchical three-level annotation scheme was proposed and implemented to tag key terms, drug interaction sentences, and drug interaction pairs. The utility of the pharmacokinetics ontology was demonstrated by annotating three pharmacokinetics studies; and the utility of the PK corpus was demonstrated by a drug interaction extraction text mining analysis.The pharmacokinetics ontology annotates both in vitro pharmacokinetics experiments and in vivo pharmacokinetics studies. The PK corpus is a highly valuable resource for the text mining of pharmacokinetics parameters and drug interactions.
Dioxirane oxidation of 3β‐substituted Δ5‐steroids

This article reviews the utility of dioxiranes in the oxidation of 3β-substituted Δ5-sterols. Dioxiranes are the smallest cyclic peroxides that contain a carbon atom. They can be generated in situ from Oxone® (2KHSO5·KHSO4·K2SO4) and a ketone. Dioxiranes are versatile oxidizing agents. The most common reaction of dioxiranes is epoxidation, with nearly 1∶1 ratios of α/β isomer products in all cases. Δ5-steroids with different side chains were epoxidized by dioxiranes generated in situ from several commercially available ketones. Although ketones function as catalyst, they were used in about an equivalent amount or large excess to accelerate the reaction.
Diastereoselective and enantioselective silylation of 2-arylcyclohexanols.

The silylation-based kinetic resolution of trans 2-arylcyclohexanols was accomplished by employing a triaryl silyl chloride as the derivatizing reagent with a commercially available isothiourea catalyst. The methodology is selective for the trans diastereomer over the cis, which provides an opportunity to selectively derivatize one stereoisomer out of a mixture of four. By employing this technology, a facile, convenient method to form a highly enantiomerically enriched silylated alcohol was accomplished through a one-pot reduction–silylation sequence that started with a 2-aryl-substituted ketone.
A Requirements-Driven Optimization Method for Acoustic Treatment Design

Acoustic treatment designers are able to attenuate specific noise sources inside turbofan engines. Subject to practical considerations, liner design variables may be manipulated to achieve a target...
Competition, Price Dispersion and Capacity Constraints: The Case of the U.S. Corn Seed Industry

This study examines the effect of competition on price dispersion and argues that the effect is contingent on the ability of firms to meet market demand. Our comparative static results show that competition among symmetrically capacity-constrained firms leads to a price decrease in the lower tail of the price distribution and a price increase in the upper tail. In contrast, competition among symmetrically capacity-unconstrained firms, or among firms with asymmetric capacities leads to an overall price increase along the distribution function. To investigate these findings empirically, we use a novel data set from the U.S. corn seed industry with farm-firm-level sales information for conventional and genetically modified corn seeds between 2004 - 2009. We estimate the empirical model using the IV Quantile Regression, and found evidence consistent with the above mentioned comparative static results. The analysis also shows that capacity-unconstrained seed firms charge a price premium, confirming the positive relationship between product availability and pricing found in our theoretical model.
New hardness results for graph and hypergraph colorings

Finding a proper coloring of a t-colorable graph G with t colors is a classic NP-hard problem when t ≥ 3. In this work, we investigate the approximate coloring problem in which the objective is to find a proper c-coloring of G where c ≥ t. We show that for all t ≥ 3, it is NP-hard to find a c-coloring when c ≤ 2t - 2. In the regime where t is small, this improves, via a unified approach, the previously best known hardness result of c ≤ max{2t - 5, t + 2⌊t/3⌋ - 1} [9, 21, 13]. For example, we show that 6-coloring a 4-colorable graph is NP-hard, improving on the NP-hardness of 5-coloring a 4-colorable graph. We also generalize this to related problems on the strong coloring of hypergraphs. A k-uniform hypergraph H is t-strong colorable (where t ≥ k) if there is a t-coloring of the vertices such that no two vertices in each hyperedge of H have the same color. We show that if t = ⌈3k/2⌉, then it is NP-hard to find a 2-coloring of the vertices of H such that no hyperedge is monochromatic. We conjecture that a similar hardness holds for t = k + 1. We establish the NP-hardness of these problems by reducing from the hardness of the Label Cover problem, via a "dictatorship test" gadget graph. By combinatorially classifying all possible colorings of this graph, we can infer labels to provide to the label cover problem. This approach generalizes the "weak polymorphism" framework of [3], though interestingly our results are "PCP-free" in that they do not require any approximation gap in the starting Label Cover instance.
Large Market Games with Near Optimal Efficiency

As is well known, many classes of markets have efficient equilibria, but this depends on agents being non-strategic, i.e. that they declare their true demands when offered goods at particular prices, or in other words, that they are price-takers. An important question is how much the equilibria degrade in the face of strategic behavior, i.e. what is the Price of Anarchy (PoA) of the market viewed as a mechanism? Often, PoA bounds are modest constants such as 4/3 or 2. Nonetheless, in practice a guarantee that no more than 25% or 50% of the economic value is lost may be unappealing. This paper asks whether significantly better bounds are possible under plausible assumptions. In particular, we look at how these worst case guarantees improve in the following large settings. -Large Walrasian auctions: These are auctions with many copies of each item and many agents. We show that the PoA tends to 1 as the market size increases, under suitable conditions, mainly that there is some uncertainty about the numbers of copies of each good and demands obey the gross substitutes condition. We also note that some such assumption is unavoidable. -Large Fisher markets: Fisher markets are a class of economies that has received considerable attention in the computer science literature. A large market is one in which at equilibrium, each buyer makes only a small fraction of the total purchases; the smaller the fraction, the larger the market. Here the main condition is that demands are based on homogeneous monotone utility functions that satisfy the gross substitutes condition. Again, the PoA tends to 1 as the market size increases. Furthermore, in each setting, we quantify the tradeoff between market size and the PoA.
Performance Measures in Earnings-Based Financial Covenants in Debt Contracts

This paper examines how performance measures are defined in major earnings-based financial covenants in loan contracts to shed light on the economic rationales underlying the contractual use of performance measures. I find an earnings-based covenant is typically based on a performance measure close to earnings before interest, tax, amortization, and depreciation expenses (EBITDA). However, my empirical analyses show that EBITDA is less useful in explaining credit risk than earnings before interest and tax expenses (EBIT) and even the bottom-line net income. Thus, measuring credit risk cannot fully explain the choice of accounting performance measures in earnings-based covenants. I conjecture that contracting parties choose an EBITDA-related measure, instead of a measure calculated after depreciation and amortization expenses (e.g., EBIT), to make the performance measure less sensitive to investment activities, which can be controlled through other contractual terms, such as a restriction on capital expenditure, and provide empirical evidence consistent with this conjecture.
Antidepressive Treatments for Parkinson's Disease: A Systematic Review and Meta-Analysis

Abstract Context Depression affects 50–70% of patients with Parkinson's disease resulting in significant comorbidity, executive dysfunction, and poorer quality of life. Divergent results from studies of different treatments preclude definite treatment recommendations. Objective To perform a systematic review and meta-analysis of published randomized controlled trials (RCTS) evaluating the efficacy of pharmacologic and behavioral interventions, and repetitive transcranial magnetic stimulation (rTMS) for depression among patients with idiopathic Parkinson's disease. Data sources Trial registers and the following databases were searched: PubMed, CINAHL, EMBASE, and PsycInfo. Bibliographies of relevant articles were cross-referenced. Study selection and data extraction RCTs comparing pharmacologic, behavioral, or rTMS with a placebo/other drugs or methods with no restrictions on participant age, gender, and duration or setting of treatment were included. Eligibility assessment was performed independently. Identified records were sequentially screened according to eligibility criteria. Differences in mean depression score and 95% confidence intervals were calculated. Results A total of 893 idiopathic Parkinson's disease patients with clinical depression across 20 RCTs were included. The overall standard mean difference for all pharmacologic interventions was 0.30 (95% CI −0.00, 0.61, p = 0.054). On stratification, there was a distinct difference in effect between antidepressants (SMD of 0.54, 95%CI 0.24, 0.83, p = 0.000) and non-antidepressants (SMD of −0.29, 95% CI −0.86, 0.29, p = 0.328). Behavioral interventions demonstrated significant efficacy with an effect size of 0.87 (95% CI 0.41, 1.33, p = 0.000). Conclusions This meta-analysis demonstrates that pharmacologic treatment with antidepressant medications, specifically the selective serotonin reuptake inhibitors (SSRIs), and behavioral interventions (CBT) significantly improved depression among Parkinson's disease patients.
Currentless reversal of Néel vector in antiferromagnets

The possibility of magnetization reversal via a bias-mediated perpendicular magnetic anisotropy is examined theoretically in an antiferromagnet. The numerical analyses based on a N\'eel vector formulation as well as the micromagnetic Landau-Lifshitz-Gilbert simulation reveal that the desired switching can be achieved through dynamical responses that are significantly different from their ferromagnetic counterparts. Instead of the usual precessional trajectories around the applied effective magnetic field, their motions are rather pendulum-like due to the layered magnetic sublattices with a strong antiparallel exchange interaction, where the inertial behavior plays a crucial role. The absence of spiral damping can also lead to faster relaxation by orders of magnitude. With no reliance on the current driven processes, the investigated mechanism is predicted with a low energy requirement of only a few aJ per switching operation in the antiferromagnets.
Course-Taking Effect on Postsecondary Enrollment of Deaf and Hard of Hearing Students

ABSTRACTData from the National Longitudinal Transition Study-2 were used to examine the effect of academic and career or technical education course-taking in high school on deaf or hard of hearing (DHH) youth’s postsecondary enrollment in 2-year, 4-year, and career or technical education institutions. We examined the proportion of academic and career or technical education courses taken, completion of algebra, and completion of an occupationally specific course of study. Propensity model analyses indicated that academic course taking significantly increased the odds that DHH students would enroll in postsecondary school. Completion of a higher proportion of career or technical education courses was not related to enrollment in postsecondary education, including career and technical education schools. Implications for practice and future research are discussed, including the importance of secondary transition planning staff both encouraging DHH students who have a goal of future postsecondary attendance to...
CEMENTING THE HIP: LEST WE FORGET

A cemented stem is certainly a good technique to choose for patients 75 years of age or older. In Europe, cemented stems remain prevalent for all ages. In my experience a patient with a cemented stem is comfortable sooner and the leg is also stronger sooner. Cement technique is the most important factor of a cemented stem and with good technique these stems have shown 30 years of longevity in published follow up studies. Technical points: 1.) Broach only. No reaming. 2.) Maintain hard cancellous bone in the metaphysis. Do not keep weak, loose bone. Brush loose bone away. 3.) Irrigate the femur until the irrigant is clear. Pack it with absorbent gauze (we use Kerlix). 4.) Place a plug and insert cement with a gun and manually pressurise the cement until you feel strong back pressure. 5.) The stem should be press-fit into the cement to force interdigitation of cement into the bone. This means the cement cannot be liquid when the stem is inserted. It must be doughy. 6.) The cement mantle should be 2–3mm circumferentially so pick the correct stem size to permit that. A centraliser will help centralise the tip of the stem in the cement column and prevent the stem being against the edge of the bone which breaks the cement column.
Does governing law affect bond spreads

Controlling for bond and issuer characteristics, bond spreads are expected to be equal across different legal jurisdictions, and differences are expected to disappear through arbitrage. However, an analysis of 435 U.S. dollar–denominated bonds issued by 53 emerging market sovereigns during 1990-2015 reveals that after the financial crisis of 2008, the launch spread of sovereign bonds issued under U.K. law has been higher than those issued under U.S. law, by 130 basis points for BB bonds and 175 basis points for B- bonds. This effect was not significant for investment grade bonds. On average, bonds issued under U.K. law had weaker ratings and shorter tenors post-crisis. The post-crisis impact of governing law on sovereign bond spreads is not explained by collective action clauses, or first-time bond issuances. Instead, the difference seems to be related to the perception that U.S. law offers stronger investor protection, and that the investor base for bonds issued under U.S. law is larger than that for bonds issued under U.K. law. The difference in spreads persists in the secondary market even after 180 days, perhaps because of the lack of liquidity, as investors tend to buy and hold these more attractive bonds on a longer term basis.
lambda-Connectedness Determination for Image Segmentation

Image segmentation is to separate an image into distinct homogeneous regions belonging to different objects. It is an essential step in image analysis and computer vision. This paper compares some segmentation technologies and attempts to find an automated way to better determine the parameters for image segmentation, especially the connectivity value of lambda in lambda-connected segmentation. Based on the theories on the maximum entropy method and Otsu's minimum variance method, we propose:(1)maximum entropy connectedness determination: a method that uses maximum entropy to determine the best lambda value in lambda-connected segmentation, and (2) minimum variance connectedness determination: a method that uses the principle of minimum variance to determine lambda value. Applying these optimization techniques in real images, the experimental results have shown great promise in the development of the new methods. In the end, we extend the above method to more general case in order to compare it with the famous Mumford-Shah method that uses variational principle and geometric measure.
Ancestry in adapting, spatially-extended populations

Selective sweeps affect neutral genetic diversity through hitchhiking. While this effect is limited to the local genomic region of the sweep in panmictic populations, we find that in spatially-extended populations the combined effects of many unlinked sweeps can affect patterns of ancestry (and therefore neutral genetic diversity) across the whole genome. Even low rates of sweeps can be enough to skew the spatial locations of ancestors such that neutral mutations that occur in individuals living outside a small region in the center of the range have virtually no chance of fixing in the population.