cssi/SciSciGPT-SciSciNet huggingface dataset:
The Use of Phage Display Technique for the Isolation of Androgen Receptor Interacting Peptides with (F/W)XXL(F/W) and FXXLY New Signature Motifs

Early studies suggested that the signature motif, LXXLL, within steroid hormone receptor p160 coregulators may play important roles for the mediation of receptor-coregulator interaction. Interestingly, several androgen receptor (AR) coregulators, such as ARA70 and ARA55, may not use such a unique motif to mediate their coregulator activity. Here we apply the phage display technique to identify some new signature motifs, (F/W)XXL(F/W) and FXXLY (where F is phenylalanine, W is tryptophan, L is leucine, Y is tyrosine, and X is any amino acid) that can influence the interaction between AR and AR coregulators. Sequence analyses found that several AR coregulators, such as ARA70, ARA55, ARA54, and FHL2, contain FXXL(F/Y) motifs. Both glutathione S-transferase pull-down assays and transient transfection reporter assays demonstrate that these AR coregulators may use the FXXL(F/Y) motif to interact with AR and exert their AR coregulator activity. Exchanging the amino acid of Phe, Trp, or Tyr in this newly identified signature motif cluster may influence these peptides to interact with AR. The motif-containing peptides, as well as ARA70 or ARA54, may require selective flanking sequences for the better interaction with AR. In addition to influencing the AR transactivation, these motifs in AR-interacting peptides/proteins were also able to influence the AR N-/C-terminal interaction. Together, our data suggest that AR interacting peptides and/or AR coregulators may utilize the (F/W)XXL(F/W) and FXXLY motifs to mediate their interaction with AR and exert their influences on the AR transactivation.
PHENOTYPIC AND REPRODUCTIVE RESPONSES OF ASPIDOSCELIS TIGRIS (SQUAMATA: TEIIDAE) TO SHIFTS IN WINTER PRECIPITATION ACROSS THE SOUTHERN SIERRA NEVADA RANGE, KERN COUNTY, CALIFORNIA

Abstract To study possible intergradation between Aspidoscelis tigris munda (west) and A. t. tigris (east) through Walker Pass, a low-elevation corridor in the southern Sierra Nevada, California, I collected 90 individuals of A. tigris from 26 May through 2 June 1994 from a 24-km transect with 3 evenly spaced sampling sites representing populations on the summit (1,555 m), west slope (1,098 m), and east slope (1,014 m). The central (summit) population lacked phenotypic intermediacy in body size (larger), color (greater melanism), and multivariate morphological variation (means of first canonical variate: summit > west > east). In addition, egg clutches were present only in females from the summit population. Stepwise regression of snout-vent length (SVL) on 6 environmental variables revealed that body size was related positively only to winter precipitation. Dominant vegetation of the 3 sampling sites substantiates the presence of a pronounced rain shadow at Walker Pass. It is likely that the phenotypic a...
Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degeneration.

Abstract To determine whether intravitreal bevacizumab could improve optical coherence tomography and visual acuity outcomes in a patient with neovascular age-related macular degeneration who was responding poorly to pegaptanib therapy, an intravitreal injection of bevacizumab (1.0 mg) was given. Within 1 week, optical coherence tomography revealed resolution of the subretinal fluid, resulting in a normal-appearing macular contour. The improved macular appearance was maintained for at least 4 weeks, and visual acuity remained stable. No inflammation was observed. An intravitreal injection of bevacizumab may provide an effective, safe, and inexpensive option for patients with age-related macular degeneration who are losing vision secondary to macular neovascularization.
The global impact of South Korean popular culture: Hallyu unbound

One of the defining social trends of our times is a steady shift in global power from West to East. In the economic sphere, this trend was documented as early as 2007 by Maddison (2007), whose data...
The Prophet Elias Puzzle

Mormon founder Joseph Smith revealed an Elias separate from the Old Testament prophet Elijah. This bifurcation has occasioned both ridicule and energetic apologetics. In this paper I demonstrate that Smith split Elias from Elijah in order to separate the traditional role of Elijah as harbinger of the Millennium from the patron angel of his new temple rites and theologies. What has long appeared a translator's gaffe opens an important window into early Mormon death culture.
Impact of Early Screening for Gestational Diabetes on Perinatal Outcomes in High-Risk Women.

Objective To examine the benefits of early gestational diabetes mellitus (GDM) screening in a high-risk population. Study Design Retrospective cohort of all singletons diagnosed with GDM with indications for early screening: GDM or macrosomia in a prior pregnancy or obesity. Subjects were classified as early ( 24 weeks) screening. Patients diagnosed with GDM were managed according to standard institutional protocols. Outcomes examined were cesarean delivery (CD), preeclampsia, large for gestational age (LGA), small for gestational age (SGA), macrosomia, and preterm birth (PTB). Results Subjects screened early were more likely to have had GDM in a prior pregnancy, hypertension, higher body mass index, and higher fasting glucose. Early and routine screening groups had similar incidences of CD (adjusted odds ratio [AOR] 0.95, 95% confidence interval [CI] 0.55–1.64), preeclampsia (AOR 0.84, 95% CI 0.38–1.83), LGA (AOR 0.90, 95% CI 0.51–1.72), SGA (AOR 0.38, 95% CI 0.13–1.13), and macrosomia (AOR 1.00, 95% CI 0.53–1.87). Subjects in the early screening group had a higher incidence of PTB (AOR 1.79, 95% CI 1.08–2.99). Conclusion We did not detect a benefit to early screening for women who met the criteria. The utility of early GDM screening requires evaluation in a prospective trial.
Cardiac Biointerventions Whatever Happened to Stem Cell and Gene Therapy

Angiogenic gene therapy and stem cell administration represent two "biologic" interventions for the treatment of cardiac disease that were first introduced more than 15 years ago but still have not achieved approval for clinical use for the treatment of myocardial ischemia and heart failure. Challenges that have been encountered in the clinical testing of these new treatment strategies have included a lack of placebo controls in phase I surgical trials and the incorporation of potentially ineffectual agent delivery via intracoronary routes. Although enthusiasm for these approaches may therefore have ebbed, new refinements in these technologies and insights into their appropriate clinical testing suggest that a resurgence of interest in these "biointerventions" may be expected in the near future.
Severe Lenalidomide-induced Interstitial Pneumonitis Requiring Mechanical Ventilation: Case Report and Review of Literature

To illustrate recognition of drug-induced lung injury and review of all published cases of lenalidomide-induced interstitial pneumonitis. Lenalidomide is an immunomodulatory thalidomide analog currently approved for the treatment of myelodysplastic syndrome and refractory multiple myeloma. Lenalidomide-induced pulmonary toxicity presenting as interstitial pneumonitis has been rarely reported. We report the case of a 62-year-old man with recent diagnosis of myelodysplastic syndrome and concomitant treatment with lenalidomide, presenting with dyspnea, weakness, cough, fever, and diffuse interstitial opacities on chest computed tomography. His symptoms became severe enough to require mechanical ventilation and intubation for respiratory failure, however, showed some response to intravenous corticosteroids. Failure to improve on antibiotics and an extensive work-up that was negative for infectious etiologies, combined with a resurgence of complaints after restarting lenalidomide treatment, led to the diagnosis of severe lenalidomide-induced lung disease. Physicians should recognize drug-induced lung disease and pursue aggressive work-up for definite diagnosis to provide appropriate treatment and prevent fatal recurrences.
A prospective comparison of platelet collection with the CS-3000 blood cell separator using the closed system and open system kits.

Each of 30 donors had two plateletapheresis procedures on the CS-3000® Blood Cell Separator (Fenwal Laboratories, Deer-field, IL). During one procedure, platelets were collected with the Closed System Apheresis Kit for Extended Platelet Storage® (Fenwal); during the other procedure the Open System Apheresis Kit® (Fenwal) was used. The same operator performed the entire collection process and all laboratory studies for both procedures for each donor. There was a statistically significant lower yield with the Closed System Kit (mean: 4.51 × 1011 platelets) than with the Open System Kit (mean: 4.76 × 1011 platelets) ( P = 0.03). There was no significant difference in lymphocyte contamination. The relatively small magnitude of the difference, however, means that product quality, longer storage time, and cost are more important considerations in selecting a kit for use.
An Interdisciplinary Perspective on the Origin of Maize

This paper addresses objections raised in an article by Bennetzen et al. (2000) in response to MacNeish and Eubanks (2000). Bennetzen et al. interpret the findings reported by MacNeish and Eubanks as opposition to the teosinte hypothesis for the origin of maize. However, by demonstrating a mutagenic mechanism that could have generated the genetic diversity essential for the transition from teosinte to maize, and the subsequent explosive evolution of maize in the archaeological record, the Tripsacum-diploperennis introgression derivatives confirm that teosinte is a progenitor of maize. Although Bennetzen et al. claim that the Tripsacum- diploperennis crosses are not credible, DNA fingerprinting verified that the hybrids contain genes from their teosinte and Tripsacum parents. Archaeobotanical remains of teosinte, Tripsacum, and hybrid specimens have been reported from Tamaulipas and Oaxaca. One of the "hybrid" specimens from Tamaulipas is virtually identical to an experimental Tripsacum-diploperennis segregate. The ability to experimentally reproduce forms that closely resemble archaeological specimens lends compelling support to the hypothesis that intergeneric hybridzation gave rise to the mutations that, through human selection, transformed teosinte into domesticated maize.
Assessing the Additional Disease Burden of Polyps in Chronic Rhinosinusitis

Objectives:This study was undertaken to determine the differential disease burden between chronic rhinosinusitis (CRS) cases with and without nasal polyposis (NP).Methods:A consecutive series of ad...
P38 Improved mortality and outcomes for patients requiring non-invasive ventilation managed in a dedicated hyper acute medical unit

Introduction Non-invasive ventilation (NIV) improves survival and outcomes in hypercapnic (type 2) respiratory failure. Following below average performance in a district hospital in the BTS national NIV audit, NIV delivery moved from acute medical and respiratory wards to a new hyper-acute medical unit (HAMU) providing level 1 nursing care and NIV. The unit is supervised by Respiratory Physicians and a dedicated NIV-trained nursing team, to improve outcomes for acutely unwell patients. A close working relationship with the Critical care team, and physical proximity to the Intensive care unit ensures rapid joint assessment and transfer of complex patients requiring invasive monitoring or intubation. Aims and objectives To compare NIV success and mortality for patients with acute type 2 respiratory failure requiring NIV, before and after introduction of HAMU. Method Data was collected for all patients in acute type 2 respiratory failure requiring NIV, for nine months before (2011–2012) and after (2012–2013) the HAMU was opened. Baseline characteristics (age, gender, performance and smoking status) were recorded. NIV success and mortality were compared and analysed. Patients requiring intubation on admission were not included. Results Baseline characteristics in both groups were similar, and comparable to national figures. NIV was successful in 56% (28/53) before, improving to 74% (43/58) after (p Conclusions NIV success and mortality rates improved significantly following opening of the HAMU. Following establishment of the HAMU, success rates are also clearly better than national comparators for 2013. NIV delivery in a dedicated unit with highly trained nurses and dedicated respiratory medical input improves outcomes in acute Type 2 Respiratory failure.
Bilingual Teaching Strategies for Optional Course in Physical Eduuction in Colleges

Bilingual education is a teaching medium based on two different languages.Its purpose is to improve students' ability of using target language by taking different courses.The optional courses in Physical education mean a teaching method that students,according to their interests,tastes and strongpoint,freely choose some sports or items as one of their learning content.The agility and livingness provide a very good language atmosphere.Not only does teaching bilingually in optional courses show us a new mode of learning language,but also it enriches P.E.teaching in college.
Expression of Tumor Necrosis Factor Ligand-Related Molecule-1A in Mice with Viral Myocarditis and Role of Astragaloside

Objective To explore the expression of tumor necrosis factor(TNF) ligand-related molecule-1A(TL1A) in mice with viral myocarditis(VM) and the role of astragaloside.Methods Fifty-five male Balb/c mice were randomly divided into 4 groups:control group,model group,low-dose intervention group and high-dose intervention group.Mice in model group,low-dose intervention group and high-dose intervention group were inoculated with 0.1 mL coxsackie B3 virus intraperitoneally.Then,mice in low-dose intervention group and high-dose intervention group were treated with 10 g·L-1 and 90 g·L-1 astragaloside solution,respectively.Mice in control group and model group were treated with 0.1 mL carboxymethycellulose solution.All mice were killed on the 15thday.Histological cross sections of heart were stained with hematoxylin-eosin and myocardial histopathologic scores were counted under optical microscope.The expressions of myocardial TL1A mRNA and protein were detected by reverse transcription polymerase chain reaction and immunohistochemistry.Results The mortality were 0,46.7%,40.0% and 13.3% in control group,model group,low-dose intervention group and high-dose intervention group,respectively.Compared with model group and low-dose intervention group,the mortality was significantly lower in high-dose intervention group(χ2=9.46,8.95,Pa0.05).The expression levels of TL1A mRNA and TL1A protein were markedly higher in model group than those in control group(Pa0.05).However,those and myocardial histopathologic scores in high-dose intervention group were decreased markedly compared with those in model group and low-dose intervention group(Pa0.05,0.01).Conclusions TL1A may participate in the pathogenesis of VM.Astragaloside can mardedly downregulate TL1A expression,attenuate myocardial damage and increase survival rate of mice with VM.
The Nephrotoxicity of Drugs

[Following is the concluding section of Dr. Schreiner's article on toxic nephropathy due to therapeutic agents. The preceding section (November) discussed effects of antimicrobial agents and of heavy metals. This section is devoted largely to the salicylates and other analgesics.]
NON-BAYESIAN FORMALISMS FOR MANAGING UNCERTAINTY

Publisher Summary Pure Bayesian theory requires the specification of a complete probabilistic model before reasoning can commence. When a full specification is not available, Bayesian practitioners use approximate methods of completing the model, methods that match common patterns of human reasoning. The noisy-OR-gate model is one such approximation; rather than specifying the conditional probabilities associated with each combination of causes, we quantify the individual cause-effect relationships, then combine them disjunctively. A more familiar method of model completion is provided by the maximum entropy principle, wherein the available specifications are treated as constraints, and the model selected is the probability distribution attaining the highest entropy under these constraints. Probabilistic logic is a method of dealing with partially specified probabilistic models, where the specification is in the form of probability assignments to a select set of logical sentences. Any such assignment defines a range of permissible complete models, and by describing the boundaries of this range one can deduce bounds on the probabilities of new sentences.
Technical Note ‐ Demand Uncertainty Reduction in Decentralized Supply Chains

This note analyzes the effects associated with reducing demand uncertainty in a decentralized supply chain comprising one manufacturer, one retailer, and a wholesale price contract that governs the transactions between them. The demand uncertainty level is parameterized through a mean-preserving spread, and the manufacturer's and the retailer's equilibrium decisions are solved accordingly. We consider the case of an exogenous retail price as well as the case of an endogenous retail price, and we find in both cases that the manufacturer's and the retailer's expected profits in equilibrium are not necessarily monotone decreasing in the uncertainty level. Thus, we find that, even if the cost of reducing demand uncertainty is zero, uncertainty reduction can hurt rather than benefit either or both members of the supply chain.
Projected changes in climatic suitability for Kinosternon turtles by 2050 and 2070

Chelonians are expected to be negatively impacted by climate change due to limited vagility and temperature-dependent sex determination. However, few studies have examined how freshwater turtle distributions may shift under different climate change scenarios. We used a maximum entropy approach to model the distribution of five widespread North American Kinosternon species (K. baurii, K. flavescens, K. hirtipes, K. sonoriense, and K. subrubrum) under four climate change scenarios. We found that areas with suitable climatic conditions for K. baurii and K. hirtipes are expected to decline substantially during the 21st century. In contrast, the area with suitable climate for K. sonoriense will remain essentially unchanged, while areas suitable for K. flavescens and K. subrubrum are expected to substantially increase. The centroid for the distribution of four of the five species shifted northward, while the centroid for K. sonoriense shifted slightly southward. Overall, centroids shifted at a median rate of 37.5 km per decade across all scenarios. Given the limited dispersal ability of turtles, it appears unlikely that range shifts will occur rapidly enough to keep pace with climate change during the 21st century. The ability of chelonians to modify behavioral and physiological responses in response to unfavorable conditions may allow turtles to persist for a time in areas that have become increasingly unsuitable, but this plasticity will likely only delay local extinctions.
Constructing a Playful Space: Eight-Legged Essays on Xixiang ji and Pipa ji

This article examines the “playful eight-legged essay” as a form of literary parody and discusses its circulation in printed editions of The Story of the Western Wing and The Story of the Lute in late imperial China. The rise of the playful eight-legged essay was part of a philosophical and literary tradition of “game-playing,” and occurred in the context of publications that appropriated canonical genres for fashionable entertainment. Reading the playful compositions against the generic conventions of the standard examination essay, on the one hand, and the original drama commentary, on the other, the author explores the playful eight-legged essay as an increasingly autonomous mode of critical commentary that was independent from, yet still associated with, the dramatic text. Employing dramatic impersonation, the essays opened up a playful space for the staging of passion and extended the appeal of the original play by involving the reader in its imaginative performance. Cet article etudie les adaptations plaisantes des “dissertations en huit jambes” comme forme de parodie litteraire et en examine la diffusion a travers les editions imprimees du Pavillon de l’ouest et de l’ Histoire du luth a la fin de l’empire. L’emergence de telles adaptations, inscrites dans une tradition ludique a la fois philosophique et litteraire, est contemporaine de la parution d’ouvrages qui detournaient les genres canoniques a des fins de recreation elegante. La lecture de ces dissertations amusantes que propose l’auteur se refere a la fois aux conventions presidant a la composition des dissertations d’examen et aux commentaires d’œuvres theâtrales proprement dits. Il en ressort que le genre de la dissertation parodique a acquis une autonomie croissante en tant que commentaire critique independant des œuvres dramatiques tout en y restant associe. En s’appropriant la voix des personnages des pieces, de tels textes ouvrent un espace de fantaisie propice a la mise en scene des passions et renforcent l’attrait des œuvres originales en impliquant le lecteur dans leur realisation imaginee.
The Cold War and the Trumanization of US Foreign Policy in the Middle East

This chapter provides a comparative case study analysis of US foreign policy toward the Middle East during the Cold War by focusing on major presidential doctrines. The cases of the Truman, Eisenhower , Nixon, Carter , and Reagan doctrines successfully test the claim that US foreign policy was characterized by continuity rather than change. Its foreign policy objectives to maintain regional hegemonic status by preventing the emergence of Soviet hegemony remained unaltered throughout the Cold War. The absence of a supranational government, possession by the Soviet Union, uncertainty of its intentions, and the need to survive dictated the aggressive reaction of the USA. Also, given its geographic location, the USA relied consistently on the grand strategy of offshore balancing to achieve its objectives.
Sports Medicine of the Foot & Ankle, the Role of Imaging

As is true for orthopedics in general, the assessment of a sports related injuries of the foot and ankle begins with a good history and physical. While many maladies are readily diagnosed, often a differential remains. In these instances, imaging assessment is often useful. Additionally, as our understanding of injury to the foot and ankle evolves, a more nuanced approach to treatment has developed. Imaging is often required to optimize treatment. This brief chapter is intended to provide an overview to imaging sports related pedal injuries. This chapter is not a comprehensive review. Whole books intended to provide such information have been written. Rather, this manuscript is intended to provide information to guide the reader in deciding when and with what imaging modality to assess a patient further. By necessity and design, this manuscript is based much upon the author’s opinions and experience. It is understood that different imaging approaches to a clinical problem are possible, depending upon the experience of the imager and which imaging modalities are readily available.
Release of Acetylcholine from Cultured Cat and Pig Glomus Cells

It is generally accepted that neurotransmitters play an essential role in the carotid body chemotransduction. Although roles of each transmitter are in debate, substantial evidence suggests that in cats acetylcholine (ACh) is involved in an excitatory step in the carotid body chemotransduction. The presence of choline acetyl transferase, an ACh-synthesizing enzyme, in glomus cells of cats has been known (Wang et al, 1989). Cholinergic receptors are localized on glomus cells (Dinger et al, 1985, 1986; Chen et al, 1981) and possibly on the carotid sinus nerve (Fitzgerald & Shirahata, 1990). Exogenously applied ACh provokes a fast and clear increase in carotid sinus nerve chemoreceptor discharge (Eyzaguirre et al, 1983; Fidone et al, 1990). Further, perfusion of the carotid body with cholinergic blockers inhibits hypoxia-mediated elevation in chemoreceptor neural activity (Fitzgerald & Shirahata, 1994). However, little is known about the release of ACh from glomus cells. This study was designed to obtain basic information as to the release pattern of ACh from cultured glomus cells.
A Four-Level Hierarchical Control Scheme for Large-scale General Multiple Linear-Quadratic Control Problems

Abstract Hierarchical control has been extended in Li (1993) to a class of large-scale nonseparable linear control systems, where the overall objective function is a nonlinear function of multiple quadratic performance indices. The solution procedure in Li (1993) applies to the nondegenerate cases. A new hierarchical control scheme with four-level solution structure is proposed in this paper to remove this restriction while deriving an analytical linear control law.
Integrating water distribution system efficiency into the water conservation strategy for California: a Los Angeles perspective.

Improving water management in California requires a transition from imported to local water resources used efficiently. To assess this transitional capacity of water retailers in metropolitan Los Angeles County, we focused on a key water management metric: the water distribution efficiency. We traced the evolution of water loss reduction policy and practices globally with emphasis on California. California Senate Bills 1420 and 555 mandate annual water auditing and reporting for urban water suppliers. We surveyed and evaluated ten water retailers9 approaches to monitor and reduce losses. Four of ten sampled water retailers monitored real losses, averaging 3–4% of total water supplied. Only three of ten sampled water retailers employed leak detection technology. Of the six sampled retailers with annual pipe replacement strategies, four retailers followed inadequate rehabilitation schedules. Most of the sampled retailers monitor water losses in percent, which misrepresents the actual volume. While a necessary step, California water loss legislation relies on the American Water Works Association Water Audit software. Verifying reported data for randomly selected retailers can ensure high data quality. Small retailers are exempt from mandatory water loss monitoring, and they need state support and resource pooling to improve their water distribution efficiency.
A Modified Dose Intensive R- CODOX-M/IVAC For HIV-Associated Burkitt and Atypical Burkitt Lymphoma(BL) Demonstrates High Cure Rates and Low Toxicity: Prospective Multicenter Phase II Trial Of The AIDS Malignancy Consortium (AMC 048)

![Graphic][1] Background Concerns about the potential toxicity of the dose-intensive regimens typically used as treatment for BL in HIV seronegative patients prompted us to modify the CODOX-M/IVAC regimen with the goal of preserving efficacy while improving tolerability. The primary objective was to improve the 1 year overall survival (OS) from 65% based on historical reports to 85%. The early stopping rule for excessive treatment related mortality was not met. Methods Major modifications of the original US NCI regimen include the addition of rituximab, reduction in cyclophosphamide to 800 mg/m2 x 2 days, vincristine 2 mg cap, methotrexate 3000 mg/m2 on day 15, reduction of lumbar punctures using combination chemotherapy and continuous infusion of the IVAC portion for the high risk patients. Antibiotic prophylaxis and growth factor support were required. HAART therapy was continued at the discretion of the local investigator. Results Thirteen AMC centers entered 34 patients. Baseline characteristics included: Classical BL/unclassifiable between DLBCL and BL/other 71/21/9%; High Risk, 94% with stage III/IV 2 (6%)/25 (74%); Median age (range) 42 (19 – 55); CD4 count 195 (0 – 721), CD4 <100, 5 ( 27%); HIV viral load 1819 (Undetectable – 1,187,968). 12 patients had a viral load <100 and only 1 had undetectable plasma HIV RNA level. Only 14 patients were on HAART at study entry. Three/14 were on their second or greater antiretroviral regimen. Treatment status View this table: View this table: Patients with gr 3-5 treatment related toxicity: any 27; hematologic 20; infection 14 including febrile neutropenia 8; 6 metabolic including 1 tumor lysis syndrome; 4 neurologic; 2 thrombotic; and 1 each coagulation, GI or pain. Notably, only 2 patients had gr 1/2 stomatitis/mucositis and none had gr 3/4. Deaths: Seven patients died. There were three treatment-related deaths including encephalopathy with hepatic failure, hepatitis B and pneumonia (1); fungal infection (1) and complications of HIV (1). There were 2 deaths due to progressive lymphoma. Despite the 5 early treatment terminations, the 1 year overall survival was 83.1% (95% CI 63.9%, 92.6%) and the one year progression free survival was 74.1% (55.5%, 86.4%). Conclusions Modifications of the CODOX-M/IVAC regimen resulted in a gr 3/4 toxicity rate significantly lower than the 100% seen in the parent regimen, and no grade 3/4 mucositis was observed. Despite a protocol completion rate of only 68%, the 1-year survival rate was 83% which compares favorably with 2 reported studies that excluded HIV + pts. (Magrath et al, 1995; Mead et al, 2008) Correlative studies to improve our understanding of HIV-BL will be presented at the meeting. Disclosures: No relevant conflicts of interest to declare. [1]: /embed/inline-graphic-2.gif
The forkhead transcription factor UNC-130/FOXD integrates both BMP and Notch signaling to regulate dorsoventral patterning of the C. elegans postembryonic mesoderm

The proper development of a multicellular organism requires precise spatial and temporal coordination of cell intrinsic and cell extrinsic regulatory mechanisms. Both Notch signaling and bone morphogenetic protein (BMP) signaling function to regulate the proper development of the C. elegans postembryonic mesoderm. We have identified the C. elegans FOXD transcription factor UNC-130 as a major target functioning downstream of both BMP signaling and Notch signaling to regulate dorsoventral patterning of the postembryonic mesoderm. We showed that unc-130 expression in the postembryonic M lineage is asymmetric: its absence of expression in the dorsal side of the M lineage requires the antagonism of BMP signaling by the zinc finger transcription factor SMA-9, while its expression in the ventral side of the M lineage is activated by LIN-12/Notch signaling. We further showed that the regulation of UNC-130 expression by BMP signaling and Notch signaling is specific to the M lineage, as the ventral expression of UNC-130 in the embryonically-derived bodywall muscles was not affected in either BMP pathway or Notch pathway mutants. Finally, we showed that the function of UNC-130 in the M lineage is independent of UNC-129, a gene previously shown to function downstream of and be repressed by UNC-130 for axon guidance. Our studies uncovered a new function of UNC-130/FOXD in the C. elegans postembryonic mesoderm, and identify UNC-130 as a critical factor that integrates two independent spatial cues for the proper patterning and fate specification of the C. elegans postembryonic mesoderm.
Effect of head motion on MRI B0 field distribution

Purpose To identify and characterize the sources of B0 field changes due to head motion, to reduce motion sensitivity in human brain MRI. Methods B0 fields were measured in 5 healthy human volunteers at various head poses. After measurement of the total field, the field originating from the subject was calculated by subtracting the external field generated by the magnet and shims. A subject-specific susceptibility model was created to quantify the contribution of the head and torso. The spatial complexity of the field changes was analyzed using spherical harmonic expansion. Results Minor head pose changes can cause substantial and spatially complex field changes in the brain. For rotations and translations of approximately 5 o and 5 mm, respectively, at 7 T, the field change that is associated with the subject's magnetization generates a standard deviation (SD) of about 10 Hz over the brain. The stationary torso contributes to this subject-associated field change significantly with a SD of about 5 Hz. The subject-associated change leads to image-corrupting phase errors in multi-shot T 2 * -weighted acquisitions. Conclusion The B0 field changes arising from head motion are problematic for multishot T 2 * -weighted imaging. Characterization of the underlying sources provides new insights into mitigation strategies, which may benefit from individualized predictive field models in addition to real-time field monitoring and correction strategies.
Utopias and Utopian Thought

Unlike environmental theory, utopian thought is concerned with a future world, a world that does not yet exist but that perhaps could come to be. Utopists examine the future rather than the present. Despite this future orientation, utopists make no claim to describe definitively what will be. Their vision is one of the potential of mankind and a call to realize that potential.
Human fetal ovaries and uteri: developmental expression of genes encoding the insulin, insulin-like growth factor I, and insulin-like growth factor II receptors.

Objective To study the messenger ribonucleic acid (mRNA) expression of receptors for insulin, insulin-like growth factor I (IGF-I), and insulin-like growth factor II (IGF-II) in human fetal ovaries and uteri at 10, 15, 19, and 22weeks' gestation. Insulin, IGF-I, and IGF-II are postulated to have paracrine and autocrine functions in the development of fetal tissues, but receptors for these growth factors have never been studied in reproductive organs of the human female fetus. Design Ribonucleic acid extracted from human fetal reproductive tissues underwent reverse transcription and polymerase chain reaction (PCR) amplification. The amplified complementary deoxyribonucleic acid (cDNA) fragments were analyzed by gel electrophoresis and restriction enzyme mapping. Results Messenger RNA expression consistent with both known forms of the insulin receptor, the IGF-I receptor, and the IGF-II receptor was observed in human fetal ovaries and uteri at 10, 15,19, and 22weeks' gestation. The identity of the PCR amplified ovarian and uterine DNA fragments were confirmed by digestion with the restriction endonucleases AvaII, DdeI, and BamHI, respectively. Conclusions This study demonstrates that mRNA for receptors for insulin, IGF-I, and IGF-II are expressed in the fetal human female genital tract. These receptors may have roles in fetal reproductive tract development.
Rocket-coronagraph photometry of the 7 March, 1970 corona from 3 to 8.5 R s

A rocket-borne coronagraph utilizing external occulting disks was used to photograph the solar corona from 3 to 9 Rs at 1931 UT on 7 March, 1970. Comparison of the rocket and ground-based observations shows a one-to-one correspondence between major streamers from the inner to the outer corona. In particular streamers over the poles are clearly visible against the background corona from 3 to ≳ 8 Rs. These rocket data had a scattered light level of ∼1.2 × 10−10Bs. The derived quiet equatorial and polar K + F corona was within 10% of the absolute brightness of standard coronal models and displayed identical radial gradients to those models. The photometric profiles of the NE limb streamer were analyzed assuming a model in which the core density follows a Gaussian distribution in directions perpendicular to the radius vector. This streamer was assumed to be rooted on the visible disk at 55 to 60° from the plane-of-the-sky as based on K-coronameter and XUV data. An uncertainty of as much as a factor of three still remains for the value of the axis density owing to uncertainty in the line-of-sight dimension of the streamer.
Impact of Built Design on Nighttime Family Presence in the Intensive Care Unit

Objective:Determine whether dedicated family space changes family presence at night in the intensive care unit (ICU).Purpose:To measure family presence at night before and after moving to an ICU wi...
Responding to What We Notice: International Student Teaching as a Pathway to Cultural Responsiveness.

This qualitative study explores short-term international student teaching (IST) as an avenue to develop two capacities related to cultural responsiveness among a group of U.S. preservice teachers (...
A Globalized Model for Mapping Wearable Seismocardiogram Signals to Whole-Body Ballistocardiogram Signals Based on Deep Learning

The ballistocardiography (BCG) signal is a measurement of the vibrations of the center of mass of the body due to the cardiac cycle and can be used for noninvasive hemodynamic monitoring. The seismocardiography (SCG) signals measure the local vibrations of the chest wall due to the cardiac cycle. While BCG is a more well-known modality, it requires the use of a modified bathroom scale or a force plate and cannot be measured in a wearable setting, whereas SCG signals can be measured using wearable accelerometers placed on the sternum. In this paper, we explore the idea of finding a mapping between zero mean and unit $\ell _{2}$ -norm SCG and BCG signal segments such that, the BCG signal can be acquired using wearable accelerometers (without retaining amplitude information). We use neural networks to find such a mapping and make use of the recently introduced UNet architecture. We trained our models on 26 healthy subjects and tested them on ten subjects. Our results show that we can estimate the aforementioned segments of the BCG signal with a median Pearson correlation coefficient of 0.71 and a median absolute deviation (MAD) of 0.17. Furthermore, our model can estimate the R-I, R-J and R-K timing intervals with median absolute errors (and MAD) of 10.00 (8.90), 6.00 (5.93), and 8.00 (5.93), respectively. We show that using all three axis of the SCG accelerometer produces the best results, whereas the head-to-foot SCG signal produces the best results when a single SCG axis is used.
Providing Compassionate End of Life Care in the Setting of Mechanical Circulatory Support

To outline key elements in providing compassionate end-of-life care for pediatric patients with end-stage heart failure on mechanical circulatory support (MCS) such as extracorporeal membrane oxygenation (ECMO) and ventricular assist devices (VADs). Approximately one in five pediatric patients with end-stage heart failure die on VAD support, with higher mortality associated with patients supported on ECMO. While it is considered ethically and legally permissible to withdraw MCS, pediatric-specific guidelines regarding indications and end-of-life management on MCS are lacking. A multidisciplinary approach with early consultation of the palliative care team is essential for all patients being considered for MCS. Guiding families through end-of-life care on MCS requires frequent and honest communication by engaging in shared decision-making regarding prognosis and potential clinical pathways, advanced care and preparedness planning, and identifying and meeting patients’/families’ goals of care.
HYDROCARBON LONG‐RANGE INTERACTION COEFFICIENTS FROM POINT CHARGE MODEL FORMULAS

Two-body interaction coefficientsC6 andd4 and the three-body coefficient γ3 are calculated for interactions between like species for a variety of hydrocarbons. Three different point charge models are employed and results are similar when Frost model Lewis set wavefunctions are used and in agreement with other literature values where available. We also consider simple Slater-Kirkwood type formulae for the coefficients and it turns out that very similar results to theab initio model values are found ford4. The formulae can also be used in conjunction with molecular fragment wavefunctions.
Translational studies of estradiol and progesterone in fear and PTSD.

Translational models of fear have greatly informed our understanding of PTSD and its underlying fear circuitry. One of the most replicated findings in the field is the two-fold higher PTSD incidenc...
The serum sFas level changes of intravenous immunoglobulin treatment of incomplete Kawasaki disease

Objective To observe the changing levels of serum sFas before and after intravenous i mmunoglobulin (IVIG) treatment of incomplete Kawasaki disease (IKD),to explore the roles of sFas in the pathogenesis of IKD and IVIG treatment mechanism.Methods Thirty eight cases of IKD children were selected as experimental group and 20 examples of the same age of children as the control group.The IKD children were treated by IVIG in combination with aspirin (ASP) ; and blood test was performed before treatment,3 days after treatment,and 14 days after treatment,respectively.Dual-resistant sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of serum sFas,plasma Fibrinogen (PT-D),d-dimer (D-D),and c-reactive protein (CRP).Results The levels of serum sFas,PT-D,D-D,and CRP were significantly higher than the control group for IKD children before treatment[(0.55 ± 0.14)ng/L vs (0.24 ±0.04) ng/L,(552.3 ± 147.2) mg/dl vs (277.3 ±82.5)mg/dl,(649.0 ±201.6) μg/L vs (315.4 ±91.8)μg/L,and(72.2 ±28.7)mg/L vs (7.2 ±2.9)mg/L; t' =12.41,9.11,8.64,13.82;All P ＜ 0.05] ;3 days after treatment,compared with those before treatment and control group,the sFas level of IKD children at the third day after treatment was significantly decreased compared to that before treatment and control groups,respectively [(0.43 ± 0.09) ng/L vs (0.55 ± 0.14) ng/L,(0.24 ± 0.04) ng/L,F =47.624,All P ＜0.05] ;For the level of sFas at the 14th day after treatment,no statistical significance was found between IKD children and the control group[(0.24 ±0.05) ng/L vs (0.24 ±0.04) ng/L,t =0.596,P ＞ 0.05].Conclusions The abnormally increased serum sFas level before IVIG treatment suggests that dysfunction of apoptosis be involved in the pathogenesis of the IKD.Intravenous immunoglobulin treatment may be involved in the apoptosis process. Key words: Gamma-globulins/therapeutic use; Injections, intravenous ; Mucocutaneous lymph node syndrome/drug therapy; Mucocutaneous lymph node syndrome/blood ; Antigens, CD95/blood; Enzyme-linked immunosorbent assay
Natural History of Pleural Complications After Lung Transplantation

Background Despite advances in lung transplantation, 5-year survival remains at 56%. Although the focus has been on chronic lung allograft dysfunction and infection, pleural complications in some may contribute to adverse outcomes. Therefore, we determined (1) the prevalence of, and risk factors for, pleural complications after lung transplantation and (2) their association with allograft function and mortality. Methods From 2006 to 2017, 1039 adults underwent primary lung transplantation at Cleveland Clinic in Cleveland, Ohio. Multivariable analyses were performed in the multiphase mixed longitudinal and hazard function domains to identify risk factors associated with allograft function and survival. Results A total of 468 patients (45%) had pleural complications, including pleural effusion in 271 (26%), pneumothorax in 152 (15%), hemothorax in 128 (12%), empyema in 47 (5%), and chylothorax in 9 (1%). Risk factors for pleural complications within the first 3 months included higher recipient-to-donor weight ratio, lower recipient albumin, and recipient-to-donor race mismatch; risk factors extending beyond 3 months included older age, hypertension, smoking history, lower lung allocation score, and donor death from anoxia. Cardiopulmonary bypass and previous thoracic interventions were not risk factors in patients with pleural effusions who were treated with thoracentesis only, and forced expiratory volume in 1 second improved after drainage; however, repeat percutaneous or surgical interventions did not impart a similar benefit. Pleural complications were associated with worse survival. Conclusions Pleural complications are common after lung transplantation and are associated with worse allograft function and survival. These complications are likely secondary to other underlying clinical problems. Malnourishment and size mismatch are modifiable risk factors.
Living with Legionella and Other Waterborne Pathogens

Legionella spp. and other opportunistic premise plumbing pathogens (OPPPs), including Pseudomonas aeruginosa, Mycobacterium avium, Stenotrophomonas maltophilia, and Acinetobacter baumannii, are normal inhabitants of natural waters, drinking water distribution systems and premise plumbing. Thus, humans are regularly exposed to these pathogens. Unfortunately, Legionella spp. and the other OPPPs share a number of features that allow them to grow and persist in premise plumbing. They form biofilms and are also relatively disinfectant-resistant, able to grow at low organic matter concentrations, and able to grow under stagnant conditions. Infections have been traced to exposure to premise plumbing or aerosols generated in showers. A number of measures can lead to reduction in OPPP numbers in premise plumbing, including elevation of water heater temperatures.
Path integral contour deformations for observables in S U (N ) gauge theory

Path integral contour deformations have been shown to mitigate sign and signal-to-noise problems associated with phase fluctuations in lattice field theories. We define a family of contour deformations applicable to $SU(N)$ lattice gauge theory that can reduce sign and signal-to-noise problems associated with complex actions and complex observables. For observables, these contours can be used to define deformed observables with identical expectation value but different variance. As a proof-of-principle, we apply machine learning techniques to optimize the deformed observables associated with Wilson loops in two dimensional $SU(2)$ and $SU(3)$ gauge theory. We study loops consisting of up to 64 plaquettes and achieve variance reduction of up to 4 orders of magnitude.