cssi/SciSciGPT-SciSciNet huggingface dataset:
Aging is associated with increased HbA1c levels, independently of glucose levels and insulin resistance, and also with decreased HbA1c diagnostic specificity.

AIM To determine whether using HbA1c for screening and management could be confounded by age differences, whether age effects can be explained by unrecognized diabetes and prediabetes, insulin resistance or postprandial hyperglycaemia, and whether the effects of aging have an impact on diagnostic accuracy. METHODS We conducted a cross-sectional analysis in adults without known diabetes in the Screening for Impaired Glucose Tolerance (SIGT) study 2005-2008 (n=1573) and the National Health and Nutrition Examination Survey (NHANES) 2005-2006 (n=1184). RESULTS Both glucose intolerance and HbA(1c) levels increased with age. In univariate analyses including all subjects, HbA(1c) levels increased by 0.93 mmol/mol (0.085%) per 10 years of age in the SIGT study and by 1.03 mmol/mol (0.094%) per 10 years in the NHANES; in both datasets, the HbA(1c) increase was 0.87 mmol/mol (0.08%) per 10 years in subjects without diabetes, and 0.76 mmol/mol (0.07%) per 10 years in subjects with normal glucose tolerance, all P<0.001. In multivariate analyses of subjects with normal glucose tolerance, the relationship between age and HbA(1c) remained significant (P<0.001) after adjustment for covariates including race, BMI, waist circumference, sagittal abdominal diameter, triglyceride/HDL ratio, and fasting and 2-h plasma glucose and other glucose levels, as assessed by an oral glucose tolerance test. In both datasets, the HbA(1c) of an 80-year-old individual with normal glucose tolerance would be 3.82 mmol/mol (0.35%) greater than that of a 30-year-old with normal glucose tolerance, a difference that is clinically significant. Moreover, the specificity of HbA(1c) -based diagnostic criteria for prediabetes decreased substantially with increasing age (P<0.0001). CONCLUSIONS In two large datasets, using different methods to measure HbA(1c), the association of age with higher HbA(1c) levels: was consistent and similar; was both statistically and clinically significant; was unexplained by features of aging; and reduced diagnostic specificity. Age should be taken into consideration when using HbA(1c) for the diagnosis and management of diabetes and prediabetes.
Effect of Fiber Bridging Stress on the Fracture Resistance of Silicon‐Carbide‐Fiber/Zircon Composites

The room-temperature fracture-resistance behavior (R-curve) of unidirectional silicon-carbide-fiber-reinforced zircon-matrix composites has been studied experimentally and numerically. The composites showed strong rising R-curve behavior from experimental results that used in situ crack-length measurements taken via optical microscopy as well as the compliance method. A numerical calculation, based on the available models, then was performed to determine the bridging-stress function from the experimental R-curve. In addition, the effect of the residual stress and constituent properties on the bridging-stress function also has been considered in the numerical calculations. These results have indicated that the bridging-stress function, which controls the fracture resistance of ceramic composites, can be obtained from the carefully measured R-curve.
Common Viral Infections in Transplant Recipients, Part 1. Herpesviruses *

Abstract Herpesviruses are common opportunistic infections in transplant recipients. Recent diagnostic and therapeutic advances have improved the prognosis of these infections in transplant patients. Among these, the introduction of quantitative PCR and other molecular assays, dissemination of antiviral susceptibility tests, and upgrading of serologic tests represent the most significant diagnostic improvements in the last 10 years. The use of pre-emptive and prophylactic therapy, coupled with the availability of new oral antivirals, represents the most significant change in the treatment arena.
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy

T cell infiltration of solid tumors is associated with favorable patient outcomes, yet the mechanisms underlying variable immune responses between individuals are not well understood. One possible modulator could be the intestinal microbiota. We compared melanoma growth in mice harboring distinct commensal microbiota and observed differences in spontaneous antitumor immunity, which were eliminated upon cohousing or after fecal transfer. Sequencing of the 16S ribosomal RNA identified Bifidobacterium as associated with the antitumor effects. Oral administration of Bifidobacterium alone improved tumor control to the same degree as programmed cell death protein 1 ligand 1 (PD-L1)–specific antibody therapy (checkpoint blockade), and combination treatment nearly abolished tumor outgrowth. Augmented dendritic cell function leading to enhanced CD8+ T cell priming and accumulation in the tumor microenvironment mediated the effect. Our data suggest that manipulating the microbiota may modulate cancer immunotherapy.
[Review] A Performer's Guide to Seventh-Century Music

This article reviews the book "A Performer's Guide to Seventeenth-Century Music," edited by Stewart Carter and Jeffery Kite-Powell, 2nd edition; Bloomington: Indiana University Press, 2012.
A metasynthesis of factors affecting self-management of chronic illness.

Aim To identify factors that may serve as facilitators and barriers to self-management described by adults living with chronic illness by conducting a qualitative metasynthesis. Background Self-management is an individuals' active management of a chronic illness in collaboration with their family members and clinicians. Design Qualitative metasynthesis. Data sources We analysed studies (N = 53) published between January 2000–May 2013 that described factors affecting self-management in chronic illness as reported by adults aged over 18 years with chronic illness. Review methods Sandelowsi and Barroso approach to qualitative metasynthesis: literature search; quality appraisal; analysis and synthesis of findings. Results Collectively, article authors reported on sixteen chronic illnesses, most commonly diabetes (N = 28) and cardiovascular disease (N = 20). Participants included men and women (mean age = 57, range 18-94) from 20 countries representing diverse races and ethnicities. We identified five categories of factors affecting self-management: Personal/Lifestyle Characteristics; Health Status; Resources; Environmental Characteristics; and Health Care System. Factors may interact to affect self-management and may exist on a continuum of positive (facilitator) to negative (barrier). Conclusion Understanding factors that influence self-management may improve assessment of self-management among adults with chronic illness and may inform interventions tailored to meet individuals' needs and improve health outcomes.
Long Waves Generated by Complex Bottom Motions

Studies of tsunami generation often employ simple models of the sea floor dislocations to permit tractable analytical solutions. Although these solutions provide basic insight into the generation process, they are incapable of producing explicit results for prototype events where both the spatial and temporal distributions of the sea floor dislocation may be quite complicated. Herein we exploit the apparent linearity of the generation process and demonstrate both the use and validity of the superposition principle to construct solutions for complex bed motions. Analytical and experimental results are presented for a monopolar dislocation (block upthrust or downthrow) with a complex time-displacement history. The time history used in the computations is obtained from an integrated accelerogram recorded at Pacoima Dam, near Los Angeles, during the earthquake of February 9, 1971. A complex spatial deformation is not used in order to enable experimental verification of the analytical results. This is unfortunate since it appears that the details of the time-displacement history are not important for prototype phenomena where the motion may be considered instantaneous. However, it is important to note that the analysis treats both space and time variations in an identical manner; hence, confirmation of this approach for complex time variations strongly suggests analogous behavior for complex spatial variations. Finally, we examine and compare several alternative time-displacement histories for the mean motion. It is shown that the results for each mean motion can be unified by introducing a velocity as a descriptive parameter which is based on the kinetic energy input of the moving bottom to the overlying fluid.
Ventricular septal defect and sudden paediatric death

While the occurrence of sudden and unexpected death in patients with isolated ventricular septal defect (VSD) has not been emphasized in the literature, the following cases demonstrate that sudden death may occur in very early life in affected individuals in the absence of a history of recent major illness. Case 1 : A previously-well three-month-old boy with a known subarterial VSD was found dead in bed. At autopsy cardiomegaly (wt. = 2×N), pulmonary oedema, ‘heart-failure’ cells and pleural effusions were found. Death was attributed to the sequelae of cardiomegaly resulting from a large subarterial VSD. Case 2: A two and a half-year-old boy with a recent history of an upper respiratory tract infection collapsed at home and was taken Immediately to the local hospital in cardiorespiratory arrest where attempted resuscitation was unsuccessful. At autopsy, massive cardiomegaly (wt. =4×N) was found associated with a large membranous VSD. There was also an early acute bronchopneumonia. Death was attributed to the sequelae of cardiomegaly resulting from a large membranous ventricular septal defect, with an exacerbating factor being an early acute bronchopneumonia. Particular difficulties that these cases demonstrate are: i) excluding SIDS as a possible cause of death in asymptomatic infants who die unexpectedly; and iil determining the veracity of the presenting history and excluding parental neglect in infants and young children who die ‘unexpectedly’. For example, in Case 2, symptoms of failure to thrive, massive cardiomegaly and early acute bronchopneumonia were merely described in the history as ‘weakness’ and a ‘cold’. Thus, when a VSD Is found at autopsy in childhood, careful review of the clinical history, presentation and associated findings should be undertaken, as the defect may have been responsible for significant pathophysiological derangements contributing to, or even causing, death. In the absence of cardiomegaly, signs of cardiac failure or associated conduction tract abnormalities, however, VSD may merely be an incidental finding necessitating the seeking of other causes of death.
Acute respiratory failure due to asthma. 2. Diagnostic and therapeutic principles.

The causes of asthmatic crises are many, a major one being respiratory infection. Among others are too little medication and too much. Sedatives, narcotics and tranquilizers are dangerous in acute asthma, and so are adrenergics in hand nebulizers. An orderly program of treatment for status asthmaticus is outlined.
Robot-human balance state transfer during full-body humanoid teleoperation using Divergent Component of Motion dynamics

This paper presents the ongoing work towards enabling humanoid robots to achieve dynamic behaviors comparable to humans. By using the concept of Divergent Component of Motion (DCM) first in introduced in [1], the present paper permits operator and robot balance synchronization using the mutual dynamics of the Center of Mass (CoM) and Center of Pressure (CoP). The Linear Inverted Pendulum Model (LIPM) with a reaction mass [2] is utilized to capture the humanoid behavior which interacts with the human operator under the Equilibrium Point (EP) [3] control assumption. Remarkable similarities between the physical system behavior and simulated results suggest the feasibility of the strategy. Experiments conducted with the MIT HERMES humanoid robot further show the performance of the proposed method.
Sodium chloride treatment of amphotericin B nephrotoxicity. Standard of care

Amphotericin B is an effective therapeutic agent for most systemic or invasive mycoses, but its usefulness is limited by the frequent occurrence of nephrotoxicity. Given the high and increasing frequency of serious fungal infections, especially in immunocompromised patients, the importance of the morbidity caused by this toxicity is substantial. Salt loading may prevent and even reverse amphotericin B-induced azotemia by an unknown mechanism. A prospective, randomized, placebo-controlled trial in a relevant patient group would strengthen the support for this simple, safe therapy, but will not likely be carried out because of practical and ethical considerations. Thus, a few prospective and limited controlled human studies may be the only supportive evidence for using this therapy. Supplementing dietary sodium chloride intake with 150 mEq of sodium chloride daily intravenously or orally beginning when or before amphotericin B therapy is initiated will likely prevent much of the observed nephrotoxicity and should be carried out routinely.
SU-C-209-07: Phantoms for Digital Breast Tomosynthesis Imaging System Evaluation

Purpose: Digital Breast Tomosynthesis (DBT) is gaining importance in breast imaging. There is a need for phantoms that can be used for image evaluation and comparison. Existing commercially available phantoms for DBT are expensive and may lack clinically relevant test objects. The purpose of this study is to develop phantoms for DBT evaluation. Methods Four phantoms have been designed and constructed to assess the image quality (IQ) of two DBT systems. The first contains a spiral of 0.3 mm SiC beads in gelatin to measure the tomographic slice thickness profile and uniformity of coverage in a series of tomographic planes. The second contains simulated tumors inclined with respect to the phantom base to assess tomographic image quality. The third has a tilted array of discs with varying contrast and diameter. This phantom was imaged alone and in a stack of TE slabs giving 2 to 10 cm thickness. The fourth has a dual wedge of glandular and adipose simulating materials. One wedge contains discs with varying diameter and thickness; the other supports a mass with six simulated spicules of varying size and a cluster of simulated calcifications. The simulated glandular tissue material varies between 35 and 100% of the total thickness (5.5 cm). Results: All phantoms were scanned successfully. The best IQ comparison was achieved with the dual wedge phantom as demonstrated by the spiculated mass and calcifications. Images were evaluated by two radiologists and one physicist. The projection images and corresponding set of tomographic planes were comparable and the synthesized projection images were inferior to the projection images for both systems. Conclusion: Four phantoms were designed, constructed and imaged on two DBT systems. They successfully demonstrated performance differences between two systems, and between true and synthesized projection images. Future work will incorporate these designs into a single phantom.
Performing CLOtest on all Pediatric Gastric Biopsies: Does It Add Diagnostic Value?

Helicobacter pylori (HP) was discovered by culture from gastric biopsies in 1982 by Drs. Marshall and Warren. Since then, urease tests have been developed for rapid diagnosis of HP infection. Our goal was to determine whether performing a urease test—CLOtest (Kimberly Clark)—on all gastric biopsies upfront has diagnostic value. All gastric biopsies performed between January 1 …
Aging induced evolution of the cyclic stress-strain behavior of lead free solders

Solder joints in electronic assemblies are often subjected to cyclic (positive/negative) mechanical strains and stresses. Such exposures can occur in variable temperature application environments or during accelerated life thermal cycling tests used for qualification. Cyclic loading leads to damage accumulation, crack initiation, crack propagation, and eventually to fatigue failure. On the microscopic level, aging causes both grain and phase coarsening, and leads to recrystallization at Sn grain boundaries. These changes of the solder microstructure are closely tied to the damage that occurs during cyclic mechanical loading. In this investigation, we have explored the effects of aging on the cyclic stress-strain and fatigue behavior of lead free solders. At the same time, changes of the solder microstructure caused by aging have been studied. Cylindrical uniaxial lead free solder test specimens (SAC305 and SAC405) have been prepared and subjected to cyclic stress/strain loading for different aging conditions. Prior to testing, the specimens were aged (preconditioned) at 125 °C for various aging times, and then the samples were subjected to cyclic loading at room temperature (25 °C). It has been observed that aging leads to the microstructural coarsening and degrades the mechanical fatigue properties, and those degradations are much more significant at the first few days of aging. From the recorded cyclic stress-strain curves, the evolution of the solder hysteresis loop, plastic strain range, and peak load with aging have been characterized and empirically modeled. Either the loop area or the plastic strain range is often considered to be the fatigue damage driving force and used in fatigue life prediction models. Similar to solder stress-strain and creep behavior, there is a strong effect of aging on the cyclic stress-strain and fatigue behavior of the solder specimens.
New systemic analgesic agents

Summary The perioperative roles of dezocine, ketorolac, and α2-agonists have not yet been completely defined, although these agents are known to have some advantages over opiate analgesics. Further investigation is needed to determine whether dezocine and ketorolac will replace or supplement opiates. α-Agonists will probably always be used as adjuncts to opiates because they are not complete analgesics. Capsaicin has not been employed systemically, but its local effects may be found to be useful in the perioperative period.
Incidental Lymphoma Discovered During Surveillance for Low-Grade Upper Tract Urothelial Carcinoma Treated Ureteroscopically: A Case Report Series.

Abstract Two cases of incidentally found follicular lymphoma during surveillance for ureteroscopically treated upper tract urothelial carcinoma with cross-sectional imaging are described. Multiple independent primary malignancies should be considered in this population.
The cost of erasure in Java generics type system

Java generics in versions 1.5 and later, are implemented by generating only one byte code representation of a generic type or method via type erasure. The essence of type erasure is the removal at compilation of all information that is related to generic type parameters and corresponding type arguments. From the point of view of the student, (s)he is left to negotiate a series of compiler and run-time errors that have little to do with programming errors but a lot to do with the Java generics implementation choice leaving sometimes with no alternative but to live with unclean compiles and a seemingly weaker type system.
Island life and isolation: The population genetics of Pacific Wrens on the North Pacific Rim

ABSTRACT Conservation of intraspecific variation is a growing focus of conservation biology. Island populations can make up a large portion of the variation of widespread species, as they are often isolated and exhibit differences in phenotype and genetic structure compared with mainland populations. We genotyped 169 Pacific Wrens (Troglodytes pacificus) from 9 locations and 6 subspecies in Alaska, USA, and British Columbia, Canada, to examine the population structure, genetic diversity, and likelihood of genetic rescue of island populations of conservation concern. We found that 25% of genetic variation was partitioned among conservation units delineated by subspecies, suggesting that the present framework of managing subspecies as separate units is warranted. Populations found farthest from possible mainland sources had the lowest genetic diversity. The Attu Island population, subspecies T. p. meligerus, had the lowest genetic diversity and highest genetic divergence of all sampled locations, a signal a...
NOVEL PLANE OF MEASUREMENT TO EVALUATE ACCURATE VALVE SIZE IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT

Background: Computed tomography angiography (CTA) is used to predict the size and orientation of transcatheter aortic valve replacement (TAVR) devices in the annulus. We previously showed that the annular plane does not predict the orientation of the valve after deployment. We hypothesized that a
Modernization, Sociological Theories of

Modernization encompasses urbanization, the application of science and technology, rapidly increasing occupational specialization, rising bureaucratization and rising educational levels, but the core of the process is industrialization, which makes it possible to escape the poverty and helplessness of subsistence agriculture. By industrializing, a society could dispel hunger, acquire the new technology now needed to compete militarily, and attain a much longer life expectancy than was possible in pre-industrial society. Adopting this goal becomes compellingly attractive from the perspective of low-income societies, once it has been demonstrated that it can be done. Today, almost every society on Earth is at some stage of the industrialization process. In advanced industrial (or ‘postmodern’) societies, the prestige of rationality, science and technology is declining. Postindustrial values give a higher priority to self-expression than to economic effectiveness: people are becoming less willing to accept the human costs of bureaucracy and of rigid social norms. Postmodern society is characterized by the decline of hierarchical institutions, and by the expansion of the realm of individual choice and mass participation. Moreover, the emergence of postindustrial society favors democratic institutions, partly because these societies require highly educated and innovative workers, who become accustomed to thinking for themselves in daily job life.
Alignment and evaluation of the cryogenic corrected infrared astronomical satellite /IRAS/ telescope

Room temperature alignment and evaluation techniques for the Infrared Astronomical Satellite (IRAS) telescope which has a primary mirror figured to correct for surface distortions at the 2K operating temperature will be discussed. Interferometric cryogenic testing of the 0.6 meter, f/1.5 lightweighted beryllium primary mirror at its intended operating temperature revealed surface distortions that could be modelled with Zernike polynomials. With this model, it was possible to derive the "inverse" of the cryo wavefront error (ideal cryo mirror) and figure the cryo correction into the primary mirror using Perkin-Elmer's Computer Controlled Polisher. It was recognized that during room temperature assembly of the system, misalignment of the secondary mirror could introduce additional unwanted aberrations that would cancel or distort the wavefront errors purposely introduced by the cryo figuring. To avoid this possible degradation and to ensure optimum telescope performance, the system Zernike polynomial co-efficients and wavefront maps generated from the in-process alignment interferograms were monitored and compared to Zernike coefficients and wavefront maps for the cryo corrected primary mirror. Performance specifications for the telescope included encircled energy on-axis and at the edge of the field of view. The predicted Zernike coefficients for the telescope at cryo temperatures were determined by subtracting the room temperature coefficients for the aligned system from the ideal cryo mirror. Encircled energy was calculated for on- and off-axis by adding the predicted Zernike coefficients to the nominal optical design prescription in the Perkin-Elmer Optical Design Computer Program. Using Zernike polynomials to iiionitor the optical quality of the telescope enabled figure and alignment errors t© be monitored, and demonstrated that the alignment tolerance was achieved. Describing the telescope's wavefront in terms of Zernike polynomials also per mitted prediction of the telescope performance for various field positions and detector or© (1980) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
When Are Models of Technology in Psychology Most Useful

In industrial-organizational (I-O) psychology, much like in the organizational sciences more broadly (Hambrick, 2007), we have a bit of an addiction to theoretical models. It is commonly assumed that developing new theory is the most valuable way to solve pressing research problems and to drive our field forward (Mathieu, 2016). However, this assumption is untested, and there is growing awareness among organizational scientists that this hardline approach, which is unusual among both the natural sciences and other social sciences, may even be damaging the reputation and influence of our field (Antonakis, 2017; Ones, Kaiser, Chamorro-Premuzic, & Svensson, 2017). As Hambrick (2007) describes, the requirement for theory first “takes an array of subtle, but significant, tolls on our field” (p. 1348). As we will describe in this article, Morelli, Potosky, Arthur, and Tippins’ (2017) suggestions, if taken at face value, will likely create such tolls by encouraging the creation of new theories of dubious value. To be clear, we agree with Morelli et al. that better theory is needed for technology's impact on I-O psychology broadly and talent assessment in particular. We disagree, however, that creating new technology theories using the approaches that I-O psychology typically employs is likely to accomplish this broader goal. Rather, it will ultimately only isolate research on I-O technologies even further from both mainstream I-O research and technology research. Given that we are already quite isolated, this would be a disastrous path.
A Room of Their Own

In this chapter we focus on the context within which creative activities occur. It is clear that certain contexts are more conducive to creativity than others. We provide examples ranging from city planning and online learning to argue for including the final users of the design in the design process itself. Christopher Alexander, architect and theorist, suggests that the only way to design “lived spaces” is to either have the inhabitants of the living space inform the design right from the beginning or to have the architects of the space closely observe the organic interactions of inhabitants before initiating the design process. We suggest that the experience of real-world interactions, and the needs of real-time, real-life users, must seamlessly become a part of a design.
Apochromatic singlets enabled by metasurface-augmented GRIN lenses

Chromatic aberrations are a primary limiting factor in thin, high-quality imaging systems. Recent advances in nanoscale manufacturing, however, have enabled the creation of metasurfaces: ultra-thin optical components with sub-wavelength features that can locally manipulate the wavefront phase. Meanwhile, there has been renewed interest in GRadient-INdex (GRIN) lenses due to the extended degrees of design freedom they offer. When combined, these two technologies can provide unparalleled imaging system performance while realizing drastic reductions in size, weight, and power. Through paraxial theory and full ray tracing we produce a lens singlet that can achieve three-color (apochromatic) correction by employing a metasurface-augmented GRIN. This apochromatic singlet has the potential for application in high-quality optical systems.
Testicular cancer: what's new in staging, prognosis, and therapy.

Improvements in the clinical staging of testicular cancer may permit the identification of clinical stage I patients at low risk of harboring metastatic disease, who could be spared treatment and observed only. Both retrospective, single-institution studies and studies of unselected, consecutive patients have confirmed that vascular invasion, lymphatic invasion, and percentage of embryonal carcinoma are predictive of metastasis in patients with low-stage nonseminoma. Whether patients with these risk factors have a worse outcome if managed with surveillance, rather than with aggressive therapy, is unclear. Low MIB-1 staining (which identifies the Ki-67 antigen) in conjunction with a low percentage of embryonal carcinoma in the testicular specimen appears to be predictive of a low probability of metastasis. Computed tomography (CT) is a useful staging tool. A new prognostic classification system for seminomas and nonseminomas was recently developed by an international consensus conference. Laparoscopic retroperitoneal lymphadenectomy appears to be a feasible staging tool with acceptable short-term morbidity. Whether laparoscopic lymph node dissection is equivalent to the open procedure when used as a therapeutic modality is not yet known. At present, laparoscopy should be used only in selected patients in a study setting. Primary chemotherapy is not recommended currently because it has not yet been proven to be superior in patients with high-risk clinical stage I nonseminoma and can cause significant long-term sequelae.[ONCOLOGY 13(12):1689-1694, 1999]
The role of superego conflicts in substance abuse and their treatment

Le retour du refoule chez les toxicomanes et les alcooliques. La toxicomanie vue comme le negatif photographique de la phobie
Discontinuation of Rivaroxaban: Filling in the Gaps

Late in 2011, rivaroxaban became the first factor Xa inhibitor to receive regulatory approval for the prevention of stroke in patients with atrial fibrillation (AF), based largely on the results of the phase III ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared with
Abstract 510: MicroRNA-8073 as a tumor suppressor and a potential diagnostic and therapeutic target

MicroRNAs (miRNAs) generated inside cells are also present in peripheral blood. MiR-8073 has been studied in various disease model, but its molecular function had been unknown. In this study, we demonstrated that miR-8073 regulates target genes that participate in cell survival and works as a tumor suppressor controlling only cancer cells. First, we observed that miR-8073 expression was evidently decreased in multiple types of cancer cells compared to normal cells, but was increased in cancer exosome secreted into cultured supernatant. We then transfected synthetic miR-8073 mimic into various cancer cell lines and found dramatic reduction in cell proliferation, which was not detected in normal cells. Additionally, in tumor xenograft mice model, three-time subcutaneous injections of miR-8073 mimic at 2nM suppressed 57% growth of colorectal tumor weight. Through mRNA expression analysis and in silico sequence analysis, we further identified five potential miR-8073 targets that plays critical roles in regulation of cell proliferation, cycle and apoptosis, and demonstrated that miR-8073 indeed bound with the 39-UTR of these target mRNAs and reduced both mRNA and protein expression. These results suggest that miR-8073 is a potential tumor suppressor, possibly discarded from cancer cells for their survival out to extracellular space, and circulates in bloodstream in the form of exosome. Our findings promise miR-8073 as a novel cancer diagnostic and therapeutic target. Citation Format: Atsuko Mizoguchi, Aiko Takayama, Taiga Arai, Yuho Kida, Junpei Kawauchi, Hiroko Sudo. MicroRNA-8073 as a tumor suppressor and a potential diagnostic and therapeutic target [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 510.
Tenth Order Mock Theta Functions: Part I, The First Four Identities

To split this lengthy chapter into manageable pieces, we proceed as follows. Section 8.2 will be devoted to establishing relevant Bailey pairs. Section 8.3 will use the Bailey pairs to provide useful representations of ϕ10(q), ψ10(q), X10(q), and χ10(q). Section 8.4 will provide useful rewritten versions of the four entries to be proved. In Section 8.5 we will then prove the rewritten identities.
Identifying patterns of care for elderly patients with non-surgically treated stage III non-small cell lung cancer: an analysis of the national cancer database.

To compare patterns of care for elderly patients versus non-elderly patients with non-surgically treated stage III non-small cell lung cancer (NSCLC) using the National Cancer Database (NCDB). We hypothesize that elderly patients are less likely to receive curative treatments, including concurrent chemoradiation (CCRT), compared to non-elderly patients. We identified patients from the NCDB between 2003 and 2014 with non-surgically treated stage III NSCLC. We defined elderly as ≥70 years old and non-elderly <70 years old. Treatment categories included: no treatment, palliative treatment (chemotherapy alone, radiation (RT) alone <59.4 Gy or chemoradiation (CRT) <59.4 Gy), or definitive treatment (RT alone ≥59.4 Gy or CRT ≥59.4 Gy). Differences in treatment between elderly and non-elderly were tested using the χ2 test. We identified 57,602 elderly and 55,928 non-elderly patients. More elderly patients received no treatment (24.5% vs. 13.2%, P < 0.0001) and the elderly were less likely to receive definitive treatment (48.5% vs. 56.3%, P < 0.0001). CCRT was delivered in a significantly smaller proportion of elderly vs. non-elderly patients (66.0% vs. 78.9%, P < 0.0001 in patients treated with definitive intent; 32.0% vs. 44.5%, P < 0.0001 in patients receiving any treatment; and 24.2% vs. 38.6%, P < 0.0001 amongst all patients). In this large study of patients with non-surgically treated stage III NSCLC, elderly patients were less likely to receive any treatment or treatment with definitive intent compared to the non-elderly. The lack of use of concurrent or sequential chemotherapy in the elderly with stage III NSCLC suggests that the optimal treatment approach for this vulnerable population remains undefined.
Child Protective Service Disparities and Serious Mental Illnesses: Results From a National Survey.

Objective:Involvement with child protective services (CPS) can have detrimental effects on children and parents alike. This study provided updated information about the prevalence of parenting amon...
Cerebellar modulation of the reward circuitry and social behavior

The cerebellum has been implicated in a number of nonmotor mental disorders such as autism spectrum disorder, schizophrenia, and addiction. However, its contribution to these disorders is not well understood. In mice, we found that the cerebellum sends direct excitatory projections to the ventral tegmental area (VTA), one of the brain regions that processes and encodes reward. Optogenetic activation of the cerebello-VTA projections was rewarding and, in a three-chamber social task, these projections were more active when the animal explored the social chamber. Intriguingly, activity in the cerebello-VTA pathway was required for the mice to show social preference in this task. Our data delineate a major, previously unappreciated role for the cerebellum in controlling the reward circuitry and social behavior.
Adult Vaccination Rates in the Mentally Ill Population: An Outpatient Improvement Project

Background: Adults who suffer with severe and persistent mental illness (SPMI) rarely access medical care to receive preventive vaccines. Aims: To increase the rate of vaccines among the SPMI population in an outpatient community mental health center (CMHC). Methods: A review of the literature identified a gap between the general population and SPMI clients in receiving preventive vaccinations. An initial mixed-method convenience survey of SPMI clients (n = 392) provided information on current vaccination status, demographics, beliefs, and interest in receiving vaccines. A vaccination program was developed to address identified barriers and increase vaccination rates. Postintervention data were collected through a mixed-method convenience survey of SPMI clients (n = 60) who participated in immunizations clinics to evaluate client satisfaction. A partnership between the health department and CMHC was developed to deliver vaccines in a nontraditional site. Vaccines administered included annual influenza; hepatitis A; hepatitis B; herpes zoster; measles, mumps, and rubella; pneumococcal; and tetanus, diphtheria, and pertussis (Tdap). Results: More than 1,000 vaccines were administered in the first 8 months, with a significant increase in vaccination rates over baseline for individual vaccines ranging from 18.75% to 83%. Postintervention survey results found a 95% satisfaction rate. Conclusions: Implementation of a vaccination program in a nontraditional site that facilitates access for SPMI clients can promote an overwhelming increase in the vaccination rates for this underserved population. Results suggest that the integration of mental health and CMHC services can have a profound positive effect on SPMI population health.
Oncologic services through Project Access and other safety net care coordination programs.

126Background: Since the 1996 formation of Project Access, a nationwide program linking uninsured, low-income, or underserved patients to specialty care, the US has experienced a growth of third-pa...
SunDown: Model-driven Per-Panel Solar Anomaly Detection for Residential Arrays

Solar arrays often experience faults that go undetected for long periods of time, resulting in generation and revenue losses. In this paper, we present SunDown, a sensorless approach for detecting per-panel faults in solar arrays. SunDown's model-driven approach leverages correlations between the power produced by adjacent panels to detect deviations from expected behavior, can handle concurrent faults in multiple panels, and performs anomaly classification to determine probable causes. Using two years of solar data from a real home and a manually generated dataset of solar faults, we show that our approach is able to detect and classify faults, including from snow, leaves and debris, and electrical failures with 99.13% accuracy, and can detect concurrent faults with 97.2% accuracy.
Fashion fades, Chanel No. 5 remains: Epistemology between Style and Technology.

Perfumes embody a chemical record of style and technology. Blurring the boundary between what counts as natural and artificial in both a material and a perceptual sense, perfumery presents us with a domain of multiple disciplinary identities relevant to social studies: art, craft, and techno-science. Despite its profound impact as a cultural practice, perfume has seldom featured in historical scholarship. The reason for this neglect is its inherently qualitative dimension: perfume cannot be understood via codified representation but requires direct acquaintance with its sensory and material basis. The historical study of perfumery thus necessitates an experimental approach that comes not without challenge. This article looks at contemporary recreations of old perfumes to identify the difficulties involved in the experimental recreation of fragrances as sensory and performative artifacts. We highlight the need for a reconceptualization of methodology for inconcrete objects of study as part of the broader interest in experimental approaches to the humanities.
Navigating the COVID-19 slipstream: A case study on living and managing access services during a global pandemic

Access Service Departments are dynamic units that often thrive in an ever changing environment. This became more apparent as libraries across the world faced the outbreak of COVID-19. The Access Se...
Transplanters on the Grasslands and the Fruits of Chain Migration

Review of: Transplanters on the Grasslands and the Fruits of Chain Migration, by Brian W. Beltman.
The Global Kinematics of the Globular Cluster M15

We present velocities for 230 stars in the outer parts of the globular cluster M15 measured with the Hydra multi-object spectrograph on the WIYN telescope. A new Bayesian technique is used for analyzing the data. The mean velocity of the cluster is -106.9+/- 0.3 km/s. Rotation with an amplitude of 1.5+/- 0.4 km/s and a position angle of 125+/-19 degrees is observed and the model including rotation is marginally favored over one without rotation. The velocity dispersion decreases from the center out to about 7' and then appears to increase slightly. This behavior is strikingly different from the continued decline of velocity dispersion with increasing radius that is expected in an isolated cluster. We interpret this as an indication of heating of the outer part of M15 by the Galactic tidal field.
Increased perioperative complication rates in patients with solid organ transplants following rotator cuff repair.

Background Rotator cuff repair is the second most common soft tissue procedure performed in orthopedics. Additionally, an increasing percentage of the population has received a solid organ transplant (SOT). The chronic use of immunosuppressants as well as a high prevalence of medical comorbidities in this population are both important risk factors when considering surgical intervention. The purpose of this study is to determine the demographic profile, comorbidity profile, and perioperative complication rate of SOT patients undergoing inpatient rotator cuff repair surgery compared to nontransplanted patients. Methods The Nationwide Inpatient Sample (NIS) database was queried from years 2002-2017 to identify all patients who underwent inpatient rotator cuff repair (n = 144,528 weighted). This group was further divided into SOT (n = 286 weighted) and nontransplant (n = 144,242 weighted) cohorts. Demographic and comorbidity analyses were performed between these groups. Additionally, a matched cohort of nontransplanted patients controlled for the year of procedure, age, sex, race, income, and hospital region was created in a 1:1 ratio to the SOT group (n = 286 each) for perioperative complication rate analysis. Results Compared to nontransplanted patients, SOT patients were more likely to have at least 1 significant medical comorbidity (98% vs. 69%, P Conclusion Compared with nontransplanted patients, SOT patients undergoing rotator cuff repair had a significantly higher comorbidity index, longer hospital stays, costlier surgeries, and were >7 times more likely to experience a perioperative complication. With nearly a quarter of all SOT patients experiencing a perioperative complication following rotator cuff repair, careful consideration for surgery as well as increased postoperative surveillance should be considered in this unique population.
Is English for Mere Employment or Social Empowerment

English has always been socially viewed as a passport to employment and therefore economic liberation and social uplift from the days of the introduction of English in India during the early colonial times. The then upper caste Indians capitalized on the opportunities available through English education to shift from temple-based occupations to company- dependent employment in the East India Company. The new converts from Hinduism, the first generation of Indian Christians chose teaching as their vocation in institutions started by missionaries. A sort of social engineering about the importance of English for employment and development was successfully created by sponsored church leaders, independent evangelists, and secular professionals who felt a burden to impart western knowledge to Indians who were perceived to be in the darkness through English. Such efforts were sanctified and legalized through the English language teaching discourses such as Charles Grant’s Observation and Macaulay’s Minute. Later, the colonial design of English for employment module was unquestioningly adopted by policy makers and accepted by people of ‘free’ India. However, empowerment aspect of colonial educational policies was conveniently sidestepped in postcolonial educational reports. The research paper proposes to investigate the colonial and post-colonial educational reports to ascertain if there is any paradigm shift in the social perception on English just as the language of higher education and employment or the language of empowerment and development.
Student Reflective Practices

For decades, reflective practices for professionals and students have been recommended by scholars. It is not clear, however, whether significant attention has been focused to understand if an inherent tendency towards the practice of reflection is demonstrated by students. A study was conducted to determine whether students demonstrate a propensity towards reflection, and if a tendency is identified, how that strategy is expressed. Further, utilizing the Human Dynamics model of Seagal and Horne, an attempt is made to determine whether particular dynamics exploit different reflective strategies.
The Golden Ages of Porn: the 1970s (Translation into Russian)

This essay focuses on the brief moment in early seventies filmmaking when the porn industry made narrative-based films such as Deep Throat (1972) and Behind the Green Door (1972). This attempt to fuse porn with mainstream culture has come back into vogue in the present, when we see a new legitimization of porn. One might say that recent representations of sex on the screen have attempted to go back to the early seventies to restart a trajectory that was never able to complete itself. The essay begins with a consideration of the origins of porn films in nineteenth-century European art before moving on to the discussion of the seventies porn films and the complex way in which European art cinema influenced mainstream porn. Related to this topic are how cultural differences within countries influence the approach to sex that is expressed on the screen. In the US, the seventies full-length porn films legitimized certain sexual acts for their audiences and centered some of the pleasure on the screen on female desire as a way to expand the audience for porn. The essay concludes with a coda on the gay male cinematic equivalents of straight seventies porn films.
Incidence of Chronic Periscapular Pain After Adult Thoracolumbar Deformity Correction and Impact on Outcomes.

Author(s): Haddad, Alexander F; Scheer, Justin K; Fury, Marissa T; Smith, Justin S; Deviren, Vedat; Ames, Christopher P | Abstract: ObjectiveExtension of the posterior upper-most instrumented vertebra (UIV) into the upper thoracic (UT) spine allows for greater deformity correction and reduced incidence of proximal junction kyphosis (PJK) in adult spinal deformity (ASD) patients. However, it may be associated with chronic postoperative scapular pain (POSP). The goal of this study was to assess the relationship between UT UIV and persistent POSP, describe the pain, and assess its impact on patient disability.MethodsASD patients who underwent multilevel posterior fusion were retrospectively identified then administered a survey regarding scapular pain and the Oswestry Disability Index (ODI), by telephone. Univariate and multivariate analysis were utilized.ResultsA total of 74 ASD patients were included in the study: 37 patients with chronic POSP and 37 without scapular pain. The mean age was 70.5 years, and 63.9% were women. There were no significant differences in clinical characteristics, including mechanical complications (PJK, pseudarthrosis, and rod fracture) or reoperation between groups. Patients with persistent POSP were more likely to have a UT than a lower thoracic UIV (p = 0.018). UT UIV was independently associated with chronic POSP on multivariate analysis (p = 0.022). ODI score was significantly higher in patients with scapular pain (p = 0.001). Chronic POSP (p = 0.001) and prior spine surgery (p = 0.037) were independently associated with ODI on multivariate analysis.ConclusionA UT UIV is independently associated with increased odds of chronic POSP, and this pain is associated with significant increases in patient disability. It is a significant clinical problem despite solid radiographic fusion and the absence of PJK.