cssi/SciSciGPT-SciSciNet huggingface dataset:
Almost all k -colorable graphs are easy to color

Abstract We describe a simple and efficient heuristic algorithm for the graph coloring problem and show that for all k ≥ 1, it finds an optimal coloring for almost all k-colorable graphs. We also show that an algorithm proposed by Brelaz and justified on experimental grounds optimally colors almost all k-colorable graphs. Efficient implementations of both algorithms are given. The first one runs in O(n + m log k) time where n is the number of vertices and m the number of edges. The new implementation of Brelaz's algorithm runs in O(m log n) time. We observe that the popular greedy heuristic works poorly on k-colorable graphs.
Distribution of selected PCB congeners in the Babcock Street sewer district: a multimedia approach to identify PCB sources in combined sewer overflows (CSOs) discharging to the Buffalo River, New York.

To evaluate sources of PCBs in combined sewer overflows (CSOs) to the Buffalo River, New York, combined sewage, sanitary flow, atmospheric wet and dry depositions, and street dust samples were collected from the Babcock Street sewer district and analyzed. Total PCB concentrations (sum of the PCB congeners quantitated) in particulate and dissolved phases of sanitary flow were 101–269 ng g-1 dry weight and 50% of the total PCB load in street dust samples. PCB congener composition in the particulate phase of CSOs reflects the congener pattern of the street dusts. In this context, it can be suggested that the local contaminated street dusts are one of the potential sources of PCBs in CSOs, which is a source of PCBs to the Buffalo River.
Sociometry and Athletic Status of Adolescents, Critical Review of Research Literature

A review of literature on the relationship between measures of social acceptability and motor characteristics is presented: data inconsistencies are commented on and a plea made for further disciplined studies.
ORGANIZATIONAL SRATEGY: From Darwin to Now: The Evolution of Organizational Strategies

On the morning tide, December 27, 1831, The HMS Beagle, captained by Robert Fitzroy, set sail from Devonport harbor in the southwest of England. She was bound, on this morning after Boxing Day, for South America and the Pacific Ocean to chart ocean depth and to undertake any necessary scientific and military investigations. As The Beagle cleared the protective embrace of the harbor and plunged into the channel proper, below her decks lay Fitzroy's friend and companion, Charles R. Darwin. Darwin was at the time miserably, wretchedly, violently seasick.
A 16-bit 65-MS/s 3.3-V pipeline ADC core in SiGe BiCMOS with 78-dB SNR and 180-fs jitter

The analog-to-digital converter presented in this work demonstrates the efficiency of the straight 2.5 bit-per-stage approach for the implementation of pipelined switched-capacitor architectures targeting up to 16-bit resolution and 65-MS/s sampling rate. The test chip has been fabricated in a 45-GHz f/sub T/, 0.4-/spl mu/m 3.3-V SiGe BiCMOS process that makes it suitable for integration with an RF front-end toward an antenna-to-DSP communication processor. Performance of 78.3 dBFS SNR, 88dBc SFDR at 65 MS/s, 1 MHz input is obtained without trimming or calibration, dissipating 970 mW total with external references. Since the 4 V/sub p-p/ signal range chosen for high SNR could lead to distortion in the Sample/Hold and the pipelined quantizer with only 3.3-V supply, a fast and accurate SPICE simulation technique for INL investigation is described that enabled detailed diagnosis of potential nonlinearity sources. Theoretical analysis and practical implementation of the clock circuit are also discussed allowing the design of a CMOS-based clock featuring 180-fs jitter, which preserves high SNR against input frequency: state-of-the-art 73.5dBFS have been observed at 150 MHz input, popular intermediate frequency (IF) for single-heterodyne BTS receivers. Finally, the figures of merit encompassing power, effective resolution, and speed rank the dynamic performance of the ADC core among the best in its class.
A process perspective to designing individual Negotiation Support Systems

This article presents a descriptive model of negotiation processes. The focus of the model is on the give-and-take activity in negotiation and the feedback and interactive nature of the process. We provide a characterization of the interactive process. The characterization developed allows recording in a computerized environment, leading to a database of negotiation case histories that can be graphically visualized. Such descriptions of negotiating behavior can help characterize and classify the behavior of an individual negotiator.
Child Custody Decision Making: The Search for Improvement

Abstract There is currently a great demand for child psychiatrist to be involved in child custody decision making. Lack of adequate training and limited criteria which deal with measurable psychological tailors have made this a difficult problem for out field to meet. This paper describes a new assessment method, called the Patent-Child Interaction Test, for use by the child psychiatrist involved in child custody decisions. Experiences in its use by a family court are described. The historical development of custody criteria and an analysis of the working philosophy of a typical family court in custody cases is described, including criteria customarily considered and problems encountered in the decision-making process.
Quantitative measurements of the generation of hydroxyl radicals by soot particles in a surrogate lung fluid

Abstract Epidemiological and toxicological studies have shown a relation between the inhalation of atmospheric particles and adverse cardiopulmonary health effects. The generation of reactive oxygen species (ROS) by particles is one current hypothesis for their toxic effects. Thus a quantitative measurement of ROS is important since that will be an index to assess the oxidative stress that particles may cause in the lung. We have developed a technique to quantitatively and specifically measure OH (the strongest biological ROS) in an aqueous, buffered extract solution as a surrogate lung fluid (SLF). Using this technique we quantitatively measured OH formation in SLF containing hydrogen peroxide (HOOH) for samples of flame soot particles, carbon black, and ambient fine particles (PM2.5). We have found that OH is formed by flame soot, independent of transition metals, with a dose-dependent linear response that depends upon HOOH concentration. Experiments with carbon black revealed that its mass-normalized OH generation was ∼10 times lower than that of flame soot, suggesting that carbon black is not a good surrogate for soot particles in health effect studies, at least in terms of oxidative stress. Mass-normalized OH generation by ambient PM2.5 was 6–30 times larger than that of flame soot. While much of the PM2.5 reactivity was suppressed by pretreating samples with a transition metal chelator, there was a significant fraction of reactivity which was not affected. Our results suggest that the in vivo generation of free radicals, specifically OH, by inhalation of PM2.5 is partially due to carbonaceous soot as well as transition metals.
AMMONIA MODELING FOR ASSESSING POTENTIAL TOXICITY TO FISH SPECIES IN THE RIO GRANDE, 1989–2002

Increasing volumes of treated and untreated human sewage discharged into rivers around the world are likely to be leading to high aquatic concentrations of toxic, unionized ammonia (NH3), with negative impacts on species and ecosystems. Tools and approaches are needed for assessing the dynamics of NH3. This paper describes a modeling approach for first-order assessment of potential NH3 toxicity in urban rivers. In this study daily dissolved NH3 concentrations in the Rio Grande of central New Mexico, USA, at the city of Albuquerque's treated sewage outfall were modeled for 1989-2002. Data for ammonium (NH4+) concentrations in the sewage and data for discharge, temperature, and pH for both sewage effluent and the river were used. We used State of New Mexico acute and chronic NH3- N concentration values (0.30 and 0.05 mg/L NH3-N, respectively) and other reported standards as benchmarks for determining NH3 toxicity in the river and for assessing potential impact on population dynamics for fish species. A critical species of concern is the Rio Grande silvery minnow (Hybognathus amarus), an endangered species in the river near Albuquerque. Results show that NH3 concentrations matched or exceeded acute levels 13%, 3%, and 4% of the time in 1989, 1991, and 1992, respectively. Modeled NH3 concentrations matched or exceeded chronic values 97%, 74%, 78%, and 11% of the time in 1989, 1991, 1992, and 1997, respectively. Exceedences ranged from 0% to 1% in later years after enhancements to the wastewater treatment plant. Modeled NH3 concentrations may differ from actual concentrations because of NH3 and NH4+ loss terms and additive terms such as mixing processes, volatilization, nitrification, sorbtion, and NH4+ uptake. We conclude that NH3 toxicity must be considered seriously for its potential ecological impacts on the Rio Grande and as a mechanism contributing to the decline of the Rio Grande fish community in general and the Rio Grande silvery minnow specifically. Conclusions drawn for the Rio Grande suggest that NH3 concentrations may be high in rivers around the world where alkaline pH values are prevalent and sewage treatment capabilities are poorly developed or absent.
Hepatic transcriptional networks induced by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) serves as a prototype for a range of environmental toxicants and as a pharmacologic probe to study signal transduction by the aryl hydrocarbon receptor (AHR). Despite a detailed understanding of how TCDD exposure leads to the transcriptional up-regulation of cytochrome P450-dependent monooxygenases, we know little about how compounds like TCDD lead to a variety of AHR-dependent toxic end points such as liver pathology, terata, thymic involution, and cancer. Using an acute exposure protocol and the toxic response of the mouse liver as a model system, we have begun a detailed microarray analysis to describe the transcriptional changes that occur after various TCDD doses and treatment times. Through correlation analysis of time- and dose-dependent toxicological end points, we are able to identify coordinately responsive transcriptional events that can be defined as primary transcriptional events and downstream events that may represent mechanistically linked sequelae or that have potential as biomarkers of toxicity.
A communication tool for cancer patients with pain: The art therapy technique of the Body Outline

Objective: The multidimensional aspect of pain suggests the use of multimodal interventions. The Memorial Sloan-Kettering Cancer Center has recently utilized the art therapy modality to help patients communicate the painful side of their illness in such a way that they can feel understood and respected. In this paper we describe a simple innovative art therapy intervention that we have developed within the Art Therapy Service in the Psychiatric Department of Memorial Sloan-Kettering Cancer Center.Method: The patients work with a Body Outline as a starting template, together with the art therapist, in sessions lasting approximately 45 minutes. They are encouraged to fill the space inside and outside the Body Outline. They can use colored pastels, markers, or watercolor or cut out images for a collage.Results: Seventy hospitalized adult cancer patients, 60 women and 10 men, used this intervention between January 1999 and May 2000. We have analyzed the variety of responses from the 70 patients, and three main groups have emerged, which have focused on the following issues: (1) visualization of physical pain, (2) communication of emotions, and (3) search for meaning/spirituality.Significance of results: The results suggest that because of its abstract symbolic feature, the Body Outline is a very flexible therapeutic intervention. It must be offered within the relationship with the art therapist, and it may fulfill quite a variety of expressive needs, from the description of physical pain to the elaboration of spiritual longings.
Esterases in Serum-Containing Growth Media Counteract Chloramphenicol Acetyltransferase Activity In Vitro

The spirochete Borrelia burgdorferi was unexpectedly found to be as susceptible to diacetyl chloramphenicol, the product of the enzyme chloramphenicol acetyltransferase, as it was to chloramphenicol itself. The susceptibilities of Escherichia coli and Bacillus subtilis, as well as that of B. burgdorferi, to diacetyl chloramphenicol were then assayed in different media. All three species were susceptible to diacetyl chloramphenicol when growth media were supplemented with rabbit serum or, to a lesser extent, human serum. Susceptibility of E. coli and B. subtilis to diacetyl chloramphenicol was not observed in the absence of serum, when horse serum was used, or when the rabbit or human serum was heated first. In the presence of 10% rabbit serum, a strain of E. coli bearing the chloramphenicol acetyltransferase (cat) gene had a fourfold-lower resistance to chloramphenicol than in the absence of serum. A plate bioassay for chloramphenicol activity showed the conversion by rabbit, mouse, and human sera but not bacterial cell extracts or heated serum of diacetyl chloramphenicol to an inhibitory compound. Deacetylation of acetyl chloramphenicol by serum components was demonstrated by using fluorescent substrates and thin-layer chromatography. These studies indicate that esterases of serum can convert diacetyl chloramphenicol back to an active antibiotic, and thus, in vitro findings may not accurately reflect the level of chloramphenicol resistance by cat-bearing bacteria in vivo.
Rapid diagnosis of Campylobacter pyloridis-associated gastritis

L'identification du germe se fait sur materiel de biopsie gastrique place dans un bouillon pour test de l'urease de Stuart
Diffusion barrier cladding in Si/SiGe resonant interband tunneling diodes and their patterned growth on PMOS source/drain regions

Si/SiGe resonant interband tunnel diodes (RITDs) employing /spl delta/-doping spikes that demonstrate negative differential resistance (NDR) at room temperature are presented. Efforts have focused on improving the tunnel diode peak-to-valley current ratio (PVCR) figure-of-merit, as well as addressing issues of manufacturability and CMOS integration. Thin SiGe layers sandwiching the B /spl delta/-doping spike used to suppress B out-diffusion are discussed. A room-temperature PVCR of 3.6 was measured with a peak current density of 0.3 kA/cm/sup 2/. Results clearly show that by introducing SiGe layers to clad the B /spl delta/-doping layer, B diffusion is suppressed during post-growth annealing, which raises the thermal budget. A higher RTA temperature appears to be more effective in reducing defects and results in a lower valley current and higher PVCR. RITDs grown by selective area molecular beam epitaxy (MBE) have been realized inside of low-temperature oxide openings, with performance comparable with RITDs grown on bulk substrates.
Albedo operators and H-equations for generalized kinetic models

Abstract For abstract kinetic equations on a half-line the albedo operator which gives the initial value as a function of the half-range boundary data, is written in terms of operator-valued generalizations of Chandrasekhar's H-functions, for which coupled non-linear equations are derived. Applications are given to transfer of polarized light, neutron transport and strong evaporation of liquids.
The ferric iron‐binding protein of pathogenic Neisseria spp. functions as a periplasmic transport protein in iron acquisition from human transferrin

The ferric iron-binding protein (Fbp) expressed by pathogenic Neisseria spp. has been proposed to play a central role in the high-affinity acquisition of iron from human transferrin. The results of this investigation provide evidence that Fbp participates in this process as a functional analogue of a Gram-negative periplasmic-binding protein component, which operates as a part of a general active transport process for the receptor-mediated, high-affinity transport of iron from human transferrin. Known properties of Fbp are correlated with those of other well-characterized periplasmic-binding proteins, including structural features and the reversible binding of ligand. Predictive of a periplasmic-binding protein, which functions in the high-affinity acquisition of iron, is that Fbp is a transient participant in the process of iron acquisition from human transferrin. Evidence for this is demonstrated by results of pulse-chase experiments. Taken together, the data described here and elsewhere suggest that pathogenic Neisseria spp. use a periplasmic-binding protein-mediated active transport mechanism for the acquisition of iron from human transferrin.
Quantitative analysis of associated and disassociated phorias: linear and nonlinear static models

Ogle et al. (1967) proposed two measures of oculomotor balance, called associated and disassociated phorias, which he assumed were equivalent. However, experimentally determined values of these phorias do not show a close correspondence. To analyze the rationale behind Ogle's assumption of equality, a linear static model was evaluated. It was found that the linear model predicts an exact correspondence between associated and disassociated phorias. Thus, this assumption depended on the presence of a linear model. To account for the discrepancy between the two measures, four equations for fixation disparity were derived corresponding to the four combinations of deadspace operator outputs. Only one of these four equally possible solutions for associated phoria corresponded to the disassociated phoria. This suggests that the variability in the four solutions may account for the scatter in the experimental data. The nonlinear model was analyzed further to determine its sensitivity to parameter changes and to show how such a model could generate the classical shape of the fixation disparity curve. >
Use of Intranasal Corticosteroids in the Management of Congestion and Sleep Disturbance in Pediatric Patients With Allergic Rhinitis

Allergic rhinitis affects a large number of children and exerts a considerable socioeconomic impact. It is underdiagnosed and inadequately treated, which predisposes children to potentially serious comorbidities. Allergic rhinitis symptoms may create nighttime breathing problems and sleep disturbances and have a negative effect on a child's ability to learn in the classroom. Although antihistamines have shown efficacy in relieving many symptoms, they have little effect on nasal congestion. This article summarizes the advantages of intranasal corticosteroids, including their effectiveness against congestion and excellent safety profile. Intranasal corticosteroids with minimal systemic bioavailability provide topical drug delivery that minimizes the potential for systemic side-effects.
Fundamental limits for distributed estimation using a sensor field

In distributed statistical inference, it is of interest to relate the statistical properties of different estimates of a parameter obtained by users who have access to different sets of observations. Suppose there are a number of sources of interest, and each user has access to observations that are a combination of data emerging from a particular subset of sources. For a given class of users, the minimax risks achievable by the users are related to each other, in the special case when the observations may be thought of as coming from a location family. Applications are given to design and resource allocation problems in sensor networks.
Remaking the Rhythms of Life: German Communities in the Age of the Nation-State. By Oliver Zimmer. (Oxford, England: Oxford University Press, 2013. Pp. ix, 395. $65.00.)

The title of this book alone should alert the reader that this is not a typical overview of German history. “Rhythm,” implying cadence and constancy, seems out of place in historical analysis. Auth...
Source localization in underwater acoustic channels using random or deterministic signals

Work concerning depth and range, estimation accuracy in a multipath environment is presented. Cramer-Rao bounds are presented for location parameter accuracy and their dependence on the velocity profile is discussed. It is shown that significant variations of the velocity profile have only minor effects on the resulting bounds. It is also shown that an unknown parameter in the velocity profile has little effect on attainable accuracy. This indicates the possibility of calibrating the velocity profile using only the target data. The authors present computer simulations of a maximum likelihood estimator for source depth which comes close to the Cramer-Rao bound when the velocity profile is known, but fails badly when the postulated profile is inaccurate and no attempt at calibration is made. >
Organelle transport: mitochondria hitch a ride on dynamic microtubules.

Summary In fission yeast, microtubules control mitochondrial position by a mechanism that is dependent on microtubule dynamics but not motor proteins. A new study now reveals the molecular basis for this novel mechanism of organelle movement.
View consistency for reliable topology control in mobile ad hoc networks

In localized topology control protocols for mobile ad hoc networks (MANETs), each node selects a few logical neighbors from its 1-hop neighbors based on its local view, constructed by exchanging periodical "Hello" messages among neighbors, and uses a small transmission range to cover those logical neighbors. Transmission range reduction conserves energy and bandwidth consumption, while still maintaining the network connectivity. However, our recent study showed that the majority of localized topology control protocols are unable to maintain connectivity in MANETs, due to network dynamics such as node mobility. One challenging problem involved is to construct consistent local views for the selection of a correct set of logical neighbors. All existing methods that enforce consistent local views require a certain degree of global synchronization. In this paper, we propose a new mobility management mechanism called weak consistency to address this problem. Compared with previous consistency schemes, this new mechanism requires no inter-nodal coordination and incurs no extra overhead. We show that a wide range of localized topology control protocols can be enhanced to ensure correct decisions based on local views that are weakly consistent. It is also proved that two recent "Hello" messages from each node are sufficient to construct weakly consistent local views, when each node updates its local views instantaneously, and three recent "Hello" messages are enough when each node updates its local view once per "Hello" interval
Continuously Tunable Optical Buffering at 40 Gb/s for Optical Packet Switching Networks

All-pass, wavelength-selective, slowlight optical buffers using cascaded micro-ring resonator filters are theoretically and experimentally studied in the context of optical packet switching router architectures. Two optical buffers fabricated in high-index contrast silica technology are compared: an 8-ring buffer with narrow resonances for wavelength selective delay and a 32-ring buffer for distortion-free delay at 10 and 40 Gb/s. Accurate measurements and configurations of the transmission of the buffers allow for precise simulations that accurately predict pattern dependent distortions, signal integrity and performance extrapolation to higher data rates. Continuously tunable delays are demonstrated up to 8 bits with minimal distortion.
Three-dimensional flowfield in a turbine nozzle passage

Detailed measurements were taken in the nozzle of a low speed single stage axial flow turbine at two axial planes inside the nozzle and on the nozzle and endwall surfaces. Velocity, turbulence and angle measurements were taken at midchord with an LDV while a five hole probe was used to measure the pressure, velocities and angles just upstream of the trailing edge. Nozzle surface and endwall static pressures were also measured. These measurements were compared to measurements previously completed at two axial planes downstream of the nozzle. The results show that at midchord, the secondary flow seems to be weak and it is in the early stages of development. Just upstream of the trailing edge, the secondary flow is clearly visible. The radially inward flow near the suction surface augments the casing passage vortex, while counteracting the hub passage vortex. Traveling downstream, the casing passage vortex remains strong while at the hub, the radially inward flow of the suction surface boundary layer has reversed direction due to the rotating hub. The blade static pressures and the passage averaged velocities compare well with Katsanis' quasi-three-dimensional code. These and other data are presented, interpreted and synthesized to understand the nozzle flow field.
Public Wage Differentials and the Public Administration “Industry”

The public sector consists of two broad sub samples, administrators and no administrators. The two groups have very different occupational compositions and contrasting patterns of compensation. Inconsistent treatment of these sub samples has led to past government differentials, which are not comparable. While administrators remain overpaid relative to their private sector counterparts, no administrators are underpaid relative to their counterparts. Moreover, public wage differentials way substantially in sign and magnitude from industry to industry. Such results demonstrate that no simple, homogeneous government differential exists.
Characterization of an E4031‐Sensitive Potassium Current in Quiescent AT‐1 Cells

IKr in Quiescent AT-1 Cells. Introduction; A cardiac culture cell line (AT-1) recently has been generated from transgenic mice. Initial studies have yielded opposing results as to the nature of the major repolarizing current(s) in these cells. The present study describes the ion selectivity, voltage dependence, and E4031 sensitivity of the major time-dependent outward current present in AT-1 cells. In addition, we have determined whether an outward current with the characteristics we observed could be capable of modulating action potential duration in a frequency-dependent manner (for stimulation cycle lengths between 250 and 1000 msec). Methods and Results: Action potentials and membrane currents were recorded from nonconffuent cultures of quiescent AT-1 cells using the “perforated patch” technique. AT-1 cells showed a round appearance 1 or 2 days after plating. An E4031-insensitive transient outward current seemed to be absent in these cells. The main time-dependent outward current was a rapidly activating and rectifying potassium current with properties similar to those of IKr. Most of the potassium current was sensitive to the benzenesulfonamide E4031 (5 μM). The same concentration of E4031 led to a 38% increase in action potential duration. Action potential parameters were independent of the stimulation cycle length within the range of 250 to 1000 msec, thus suggesting that the membrane currents involved in the action potential of AT-1 cells are completely reset within a diastolic interval of approximately 150 msec. Conclusion: AT-1 cells present a unique electrophysiologic phenotype, which is clearly different from that reported for freshly dissociated adult atrial or ventricular myocytes from other species. AT-1 cells may be a good model to study IKr, since there seems to be minimal contamination by other outward conductances (such as ik). In addition, the feasibility of culturing AT-1 cells provides us with a system where electrophysiologic experiments on IKr currents could be combined with biochemical or molecular biological studies requiring significant periods of incubation in a cell culture system.
Assessment of quality of life outcomes using the pediatric quality of life inventory survey in prenatally diagnosed congenital diaphragmatic hernia patients.

Abstract Introduction Congenital diaphragmatic hernia patients can have significant postnatal morbidity. To date, there has been no quality of life (QOL) study in a prenatally diagnosed CDH patient population, assessing prenatal disease severity and QOL. The purpose of this pilot study was to assess the QOL in a single institution fetal center CDH experience. Methods The study was a retrospective cohort study of CDH patients diagnosed by fetal ultrasound and MRI at a fetal center between March 2002-March 2014. Parents of children ≥2years were contacted by telephone to participate in the validated Pediatric Quality of Life Inventory (PedsQL™, Version 4.0). Results Of 95 CDH survivors, 68 met inclusion criteria, of which 28 (42%) completed the survey (mean age, range: 5.5, 2.3–11.7years). Based on prenatal markers of disease severity, there were no differences in performance between those with mild or severe forms of CDH. Overall, patients had minimal QOL limitations, but those with limitations had a higher risk for oxygen dependence at 30days of life (71%v. 29%, OR 0.16, CI, 0.031–0.82, p=0.02). ECMO was not associated with significantly worse QOL in physical or psychosocial functioning. Cronbach's alpha reliability coefficient yielded a correlation of 0.951 for the overall survey, 0.911 for physical functioning, and 0.901 for psychosocial functioning questions. Conclusions Patients that are prenatally diagnosed with severe forms of CDH have similar QOL outcomes across all categories of physical and psychosocial functioning. This pilot study is encouraging and may allow improved counseling for expectant parents of CDH patients.
Chromosome Instability Underlies Stem Cell Dysfunction and Neoplasia In Widespread Hematologic Disease Induced By Deregulated Cyclin E

The Fbw7 ubiquitin ligase controls the expression of a number of oncoprotein substrates including cyclin E, Notch, c-Jun, and c-Myc. Using a knock-in mouse model (cyclin ET74A T393A), in which mutations were introduced into the cyclin E1 allele ( Ccne1 ) to disrupt Fbw7-mediated ubiquitination specifically, we previously found that cyclin E dysregulation in vivo induces anemia with defects in erythroid differentiation and morphologic dysplasia of erythroid progenitors. We also found that cyclin ET74A T393A mice have fewer hematopoietic stem cells (HSCs) during steady-state hematopoiesis compared to wild-type counterparts. We performed serial transplantation experiments to assay comprehensively the self-renewal and multi-lineage reconstitution capacities of cyclin ET74A T393A HSCs. Contrary to our expectations, cyclin ET74A T393A HSC self-renewal appears normal after three rounds of serial transplantation; however, we identified defects in their multi-lineage reconstitution function. In cyclin ET74A T393A bone marrow erythroid cells, induction of a p53-dependent DNA damage response pathway appears to promote compensated erythropoiesis. In cyclin ET74A T393A HSCs, we similarly observed induced expression of canonical p53 target genes. We studied the effect of p53-loss on cyclin ET74A T393A HSCs and found that p53-null; cyclin ET74A T393A HSCs exhibit defects in both self-renewal and multi-lineage reconstitution. By enumerating chromosomes in metaphase spreads, we found p53-null; cyclin ET74A T393A hematopoietic stem and progenitor cells (HSPCs) demonstrate significant chromosomal instability (CIN). Importantly, we can recapitulate the self-renewal defects and CIN of cyclin ET74A T393A HSPCs with intact p53 by treating recipient animals with a single dose of 5-fluorouracil (5-FU). Thus, chromosomal stability is a key determinant for the maintenance of HSC self-renewal, and hematologic stress appears to unmask the potential for impaired Fbw7-dependent cyclin E ubiquitination to engender CIN in the presence of intact p53. Moreover, CIN is a characteristic feature of fatal T-cell malignancies that ultimately develop in recipients of cyclin ET74A T393A; p53-null HSCs. In pre-malignant thymocytes isolated from recipients of cyclin ET74A T393A; p53-null HSCs, aneuploidy is associated with the marked potentiation of cyclin E kinase activity in these cells by p53-loss. In malignant thymocytes, comparative genome hybridization analysis demonstrates clonal CIN associated with deregulated cyclin E expression combined with p53-loss. In toto, our data demonstrate the functional importance of cyclin E regulation by the Fbw7 ubiquitin ligase to the hematopoietic system and highlight CIN as a key mechanism underlying HSC dysfunction and malignancy induced by deregulated cyclin E in vivo. Disclosures: No relevant conflicts of interest to declare.
The Foreign Corrupt Practices Act and the Price, Volume, and Termination Rate of Cross-Border Mergers and Acquisitions

Congress enacted the Foreign Corrupt Practices Act (FCPA) in 1977. It has since become an important factor in American firms decision-making in acquiring foreign targets, but its economic impact has gone largely unexamined. I analyze the influence of the risk of an enforcement action under the FCPA on the prices of cross-border mergers and acquisitions (CBMA). In a sample of 13,002 CBMA deals by American acquirers from 1996-2010, I find statistically significant results, suggesting that firms pay on average 3.9 – 5.1% less to acquire targets in countries with higher risk of attention from the FCPA.
Disability-Free Life Expectancy Over 30 Years: A Growing Female Disadvantage in the US Population

Objectives. To examine changes in active life expectancy in the United States over 30 years for older men and women (aged ≥ 65 years).Methods. We used the 1982 and 2004 National Long Term Care Survey and the 2011 National Health and Aging Trends Study to estimate age-specific mortality and disability rates, the overall chances of survival and of surviving without disability, and years of active life for men and women.Results. For older men, longevity has increased, disability has been postponed to older ages, disability prevalence has fallen, and the percentage of remaining life spent active has increased. However, for older women, small longevity increases have been accompanied by even smaller postponements in disability, a reversal of a downward trend in moderate disability, and stagnation of active life as a percentage of life expectancy. As a consequence, older women no longer live more active years than men, despite their longer lives.Conclusions. Neither a compression nor expansion of late-life disa...
Gutward, ho! pDCs in SIV infection.

In this issue of Blood , Kwa and colleagues demonstrate that in pathogenic simian immunodeficiency virus (SIV) infection in rhesus macaques, plasmacytoid dendritic cells (pDCs) up-regulate the gut-homing integrin α4β7 and are recruited to the colorectum where they contribute to immune activation.[
Nonrandom Survival of Cochliobolus Carbonum Ascospores in Asci Bearing Less Than Eight Ascospores

Nearly all ascospores of Cochliobolus carbonum occur in asci with fewer than seven spores. The proportions of 4- and 6-spored asci yielding segregation ratios of 3:3 or 3:1, respectively, indicate ...
Segregation, Polarization, and Ethnic Conflict

An index of ethnic segregation conveys the extent of spatial mixing of ethnic groups, whereas an index of ethnic polarization and similar diversity measures show the overall balance between the groups. We present a game-theoretic model of conflict in which local success of one ethnic group encourages attacks by its co-ethnics in neighboring areas. Conditional on conflict breaking out, we find that for highly ethnically polarized societies, increasing ethnic segregation decreases the incidence and intensity of conflict. In contrast, in societies with low ethnic polarization, increasing segregation increases conflict. This is because segregation and polarization jointly determine the spread of conflict, an important channel that has been neglected previously. We find strong empirical support for model predictions in two very different conflicts: Hindu–Muslim riots in the 1980s and 1990s in India and the Bosnian Civil War from 1992 to 1995.
Primary Bladder Closure and Bladder Neck Reconstruction in Classical Bladder Exstrophy

AbstractThe surgical results of 28 consecutive initial bladder closures and 25 consecutive initial bladder neck reconstructions performed for classical bladder exstrophy at our hospital between 1975 and 1982 are presented. Partial bladder prolapse occurred in 2 cases and complete wound dehiscence never occurred following the initial primary bladder closure. Urinary continence following bladder neck reconstruction was assessed from parental interviews. An excellent surgical result was defined either as achievement of a daytime dry interval for more than 3 hours or less than 1 incontinent episode per day. According to these parameters, an excellent surgical result was achieved in 86 and 80 per cent of children, respectively. In 21 children evaluated with excretory urograms between ½ and 6 years after bladder neck reconstruction 10 per cent of the renal units showed significant hydronephrosis and deterioration of function. The 2 patients who had upper tract deterioration were not followed postoperatively at ...
Psychotherapy and Behavior Therapy

This chapter discusses the various types of psychotherapy that the intern may practice during his or her training year. It provides interns with a general overview of psychotherapy in clinical practice, and focuses on the types of psychotherapy training that may be obtained during internship. The chapter concludes with a consideration of how one chooses the most appropriate treatment for a particular patient, and a recommendation that interns expose themselves to the broadest range of training experiences possible.
A Summary and Synthesis of Contemporary Empirical Evidence Regarding the Effects of the Drug Abuse Resistance Education Program (D.A.R.E.)

The prevention of drug abuse is an especially salient topic for school psychologists and other educational professionals. Schools are the primary setting for providing education and information aimed at the prevention of drug abuse. Previous meta-analyses (Ennett, et al., 1994; West & O’Neal, 2004) indicate that one of the nation’s most popular drug prevention programs, the Drug Abuse Resistance Education program (D.A.R.E.), was not effective in reducing illicit drug use among youths. In 2003, D.A.R.E. was modified in an attempt to make it more effective. The purpose of this review is to summarize and synthesize the contemporary empirical evidence, which includes six studies focusing on the old D.A.R.E. and one study focusing on the new D.A.R.E., regarding outcomes associated with the modified D.A.R.E. program. Recent studies offer mixed evidence regarding the effectiveness of the new D.A.R.E curriculum, thus, further systematic investigation is warranted to better understand student outcomes associated with the new D.A.R.E curriculum. This information is particularly valuable for school psychologists, administrators, and other education professionals responsible for identifying empirically supported programs for use in schools.
Nb2O5 and Ta2O5 Thin Films from Polyoxometalate Precursors: A Single Proton Makes a Difference

Thin film materials from water-based precursors follow the principals of green chemistry, leading to a more sustainable future in the energy intensive era in which we currently reside. While simple in practice, aqueous metal-oxide chemistry is complex at the molecular level. Here we develop the first water-based formation of Nb2O5 and Ta2O5 thin films; utilizing tetramethylammonium salts of [H2Ta6O19]6– and [H3Nb6O19]5– polyoxometalates. Although the clusters are structurally identical group V analogues and differ only by a single proton, this difference has a considerable influence on the quality of the films that are obtained. Through characterization of the solid-state precursor (single-crystal X-ray diffraction), the aqueous precursor solution (X-ray scattering), and the thin films (atomic force and scanning electron microscopies, X-ray diffraction, and reflectivity), we rationalize the important roles of cluster protonation that carry through all chemical processes from the precursor to the metal oxi...
The urgent need for contemporary clinical trials in patients with asymptomatic carotid stenosis

Asymptomatic extracranial internal carotid artery atherosclerotic stenosis increases with age and is more common in men. Studies performed more than 2 decades ago showed that carotid endarterectomy reduced the rate of stroke in carefully selected patients with asymptomatic carotid stenosis compared with medical therapy in the long term. Those trials were completed more than 20 years ago and with advances in the treatment of atherosclerotic disease, the question has been raised to as to whether endarterectomy is still of value for patients with asymptomatic narrowing. Perioperative risk of carotid revascularization procedures has also declined. Due to improvements in both medical and surgical treatments for carotid artery stenosis, it is timely to reevaluate the efficacy of carotid intervention relative to medical treatment for patients with asymptomatic stenosis.
Environmental Policy Instruments and Uncertainties Under Free Trade and Capital Mobility

We analyze the properties of environmental policy instruments in the face of uncertainty for an economy that is open to international trade and capital mobility (open economy). We incorporate three static environmental policy instruments which could be inefficient: cap-and-trade, pollution tax and emission intensity standard in our model and evaluate their properties under an exogenous temporary productivity shocks to simulate business cycles and an exogenous temporary abatement cost shock to represent reduced costs of clean inputs (for example cheap natural gas due to fracking). We then compare impacts on welfare, pollution levels, outputs, consumption, investment, supply of labor and trade flows in the economy. To date this literature has either focused on either economies under autarky or in a static modeling framework with a focus on strategic interaction among agents and thus ignore an additional channel of international trade and capital mobility that may smooth the intensity of business cycle shock or abatement cost breakthrough. We develop a small open economy (SOE) dynamic stochastic general equilibrium (DSGE) model where we incorporate international trade and capital mobility. We evaluate long term properties and use DYNARE to evaluate short term (dynamic) properties. Our results suggest that the preferred environmental policy instrument varies with the source of uncertainty. The cap-and-trade policies are best suited to smooth the business cycle while pollution taxes and intensity targets are most effective in the face of abatement cost shocks. We find that the magnitude of the productivity shock's impact on the economy swamps the impact of an abatement cost shock. This suggests that a cap-and-trade policy, which performs best in the face of productivity shocks, should be the preferred policy instrument in most cases. In our model, calibrated to Canadian data, a one standard deviation productivity shock has nearly an order of magnitude larger impact than a one standard deviation abatement cost shock.
Making Visible the Relationship Between Teachers’ Noticing for Equity and Equitable Teaching Practice

This study examines mathematics teachers’ noticing for equity. Noticing for equity is a critically important practice given research that documents how particular groups of students feel more or less empowered to take up ambitious mathematics practices. We conducted classroom observations and a series of noticing interviews with four secondary mathematics teachers nominated as exceptional equitable mathematics teachers. Using qualitative methods, we conducted a cross-case analysis to identify common instructional practices these teachers enacted to close participation gaps in their classrooms, as well as the associated ways of noticing during instruction. These findings document the intricate relationship between what teachers committed to equitable mathematics instruction attend to, how they reason about observed phenomena, and how they use this information to make instructional decisions.
Polychlorinated biphenyls (PCBs) in recreational marina sediments of San Diego Bay, southern California.

Abstract Polychlorinated biphenyl (PCB) concentrations were determined in surface sediments from three recreational marinas in San Diego Bay, California. Total PCB concentrations ranged from 23 to 153, 31–294, and 151–1387 ng g− 1 for Shelter Island Yacht Basin (SIYB), Harbor Island West (HW) and Harbor Island East (HE), respectively. PCB concentrations were significantly higher in HE and PCB group composition differed relative to HW and SIYB, which were not significantly different from each other in concentration or group composition. In marina sediments there was a predominance (82–85%) of heavier molecular weight PCBs with homologous groups (6CL-7CL) comprising 59% of the total. In HE 75% of the sites exceeded the effect range median (ERM), and toxicity equivalence (TEQ dioxin-like PCBs) values were higher relative to those of HW and SIYB, suggesting a potential ecotoxicological risk.
Immune checkpoint inhibition in elderly non-small cell lung cancer patients.

137Background: Age-related changes in the immune system are dynamic and complex. Use of anti-PD-1/PD-L1 therapy in advanced non-small cell lung cancer (NSCLC), with median patient age of 71, has rapidly become standard of care. Understanding how senescent remodeling of the immune system may affect outcomes with anti-PD-1/PD-L1 therapy is poorly understood. Although trends in phase III clinical trials of anti-PD-1/PD-L1 therapy suggest a potential lack of clinical efficacy in patients ≥ 75 years of age, the proportion of treated patients in this age range was low. The use and outcomes of these agents in this population treated in clinical practice has not been reported. Methods: The Johns Hopkins Upper Aerodigestive Diseases Malignancies and Immunotherapy Database was queried for all patients treated with anti-PD-1/PD-L1 agents as part of a clinical trial or as standard of care, from 2007 to 2017. Patients ≥ 75 years old were assessed for demographic, response, toxicity and survival data as of September 20...
Safety and effectiveness of amoxicillin in the treatment of inflammatory acne.

Abstract Acne is a common skin disease that predominantly affects teenagers and young adults. Systemic antibiotic therapy, including tetracyclines, macrolides, and trimethoprim-sulfamethoxazole, is indicated in moderate-to-severe inflammatory disease. However, in certain cases, these antibiotics and other commonly prescribed treatments including oral contraceptives, spironolactone, and isotretinoin may be prohibited, especially in cases of pregnancy and drug intolerance. In this retrospective study, we assessed the safety and efficacy of systemic amoxicillin, which has a favorable tolerability profile and compatibility with pregnancy in the treatment of inflammatory acne.