cssi/SciSciGPT-SciSciNet huggingface dataset:
Ischemic myocardial injury in rapidly paced dogs: Contribution to ventricular dysfunction

Chronic rapid ventricular pacing in the dog has been shown to provide a predictable and stable model of heart failure for which the operative pathomechanism remains in question. In a group of 20 dogs with congestive failure induced by rapid ventricular pacing for a mean duration of 29.5 ± 13.1 days (range 7 to 55 days), mean left ventricular end diastolic pressure (LVEDP) was elevated as compared with unpaced controls (23.2 ± 2.7 mmHg vs. 2.0 ± 0 mmHg, p < 0.001). Gross myocardial hemorrhage was present at autopsy in 9 of 20 (45%) paced animals, and necrosis was present in 5 of 20 (25%). Histologic findings included acute ischemic myocardial injury with contraction band necrosis, wavy myofibers, and coagulation necrosis ranging from 0 to 4 lesions per paced animal (1.4 ± 1.4, mean ± SD), compared with none in unpaced animals (p < 0.03). Healed ischemic lesions ranged from 0 to 10 per animal (mean 3.2 ± 2.9) versus none in control animals (p < 0.0001). Total injury score (acute plus healed) for each paced animal ranged from 0 to 12 (mean 4.6 ± 2.9), compared with no injury in nonpaced controls (p < 0.0001). Thus ischemic injury reflected by multiple foci of acute and healed myocardial injury is a prominent and common feature in the canine rapid ventricular pacing model of heart failure.
The Companion Course: A Pilot Project to Teach Discipline‐Specific Library Research Skills

In early 1997, fueled by reports from the university administration of declining enrollments and student retention problems, the University of Oregon Library System formed a task force to explore opportunities to boost student retention. The most popular recommendation from the task force was to develop library courses that would address discipline‐specific information needs in a number of library‐intensive courses, especially in journalism, management, psychology, and women’s studies. In this article, Bell and Benedicto discuss the pilot program that arose out of this recommendation and that was conducted over spring term 1998.
Tomographic evidence for wholesale underthrusting of India beneath the entire Tibetan plateau

We analyzed a global tomographic model for the Tibet–Himalayan collision zone, which indicates that the Indian lithospheric slab has been subducted subhorizontally beneath nearly the entire Tibetan plateau to depths of 165–260 km. Tibetan velocity structure is low in its crust and high in its lithospheric mantle at depths between 75 and 120 km. We interpret an asthenospheric layer positioned above the subducted Indian slab at depths between 120 and 165 km beneath the Tibetan plateau. Beneath the central portion of the plateau a lowvelocity anomaly exists from the crust down to 310 km depth, indicating mantle upwelling through a weakened part of the subducted slab. We present a model, which explains that, the uplift history and low relief of the Tibetan plateau is a result of subhorizontal subduction and heating of Indian lithosphere that is separated from Tibetan lithosphere by a thin channel of asthenosphere. Two predictions made by our model are: (1) the amount of shortening in the Himalayas is equivalent to the amount of underthrusted Indian mantle lithosphere; and (2) a young mantle geochemical signature should be present along the entire southern portion of the Tibetan plateau. q 2004 Elsevier Ltd. All rights reserved.
ANDROGEN THERAPY IN THE HUMAN FEMALE

THE THERAPEUTIC USE of androgens for gynecologic disorders is the outgrowth of the obser-vations by biochemists, physiologists and clini-cians concerning the presence and role of the normally occurring androgens in the female. Koch and Gal-lagher identified substances in the testicles of bulls and David and Laqueur separated an androgenic com-pound called testosterone from the same source. Later it was produced synthetically by Butenandt and. Rusicka. Koch reported the presence of 4 androgenic substances in the human urine but could not isolate testosterone. One of these four androgens was androsterone which Butenandt and Tscherning were able to crystallize. Later, the Callows identified androsterone and dehydroandrosterone in the urine of normal women. They found androgens even in puberty, though in small amounts varying from 1.1 to 3 international units. Gallagher et al. stated that normal young women excrete 2,6 i.u. of androgen daily in the urine and men excrete 40 to 56 i.u. Only traces were found be...
Criminal Thinking as a Predictor of Prison Misconduct and Mediator of the Static Risk–Infractions Relationship

The General Criminal Thinking (GCT) score of the Psychological Inventory of Criminal Thinking Styles (PICTS) was found to successfully predict institutional adjustment in 2,487 male medium security...
Bilateral Thoracotomy and Inferior Sternotomy for Bypass Grafting After Esophagostomy

In the presence of a cervical esophagostomy, a median sternotomy may jeopardize the stoma, risk mediastinal or sternal infection, and potentially compromise future esophageal operations. Coronary artery bypass grafting was performed using a modified bilateral thoracotomy before esophageal reconstruction in a patient with cervical esophagostomy. The surgical technique is described with a review of the relevant literature.
What can post-mortem studies tell us about the pathoetiology of suicide?

Suicide is a major public health concern; however, its neurobiology is unclear. Post-mortem brain tissue obtained from suicide victims and normal controls offers a useful method for studying the neurobiology of suicide. Despite several limitations, these studies have offered important leads in the neurobiology of suicide. In this article, we discuss some important findings resulting from these studies, focusing on serotonergic mechanisms, signal transduction systems, neuroendocrine studies and immune function abnormalities in suicide. These studies suggest that abnormalities of certain receptor subtypes, components of signaling systems such as protein kinase C and protein kinase A, transcription factors such as cyclic AMP response element-binding protein and neurotrophins may play an important role in the pathophysiology of suicide. These studies also suggest abnormalities of hypothalamic–pituitary–adrenal axis system components, feedback mechanisms and cytokines, which are chemical mediators of the immun...
SVSS: Intelligent video surveillance system for aircraft

Safety and security are the most discussed topics in the aviation field. The latest security initiatives in the field of aviation propose the aircraft carriers to implement video surveillance within the aircraft at strategic locations. The current proposals allow the video surveillance data to be stored within the aircraft and monitored by one of the flight crew. The monitoring crew will be responsible for identifying the anomaly within the aircraft and take necessary preventive actions. With the introduction of additional technology within the aircraft, mere human perception may not be sufficient to make a decision. In this research work, the authors explore the possibility of implementing a smart video surveillance system (SVSS) within the aircraft that is tuned toward detecting the behavioral anomaly within the aircraft. The SVSS will generate security triggers when it detects an anomaly within the aircraft. These triggers could be combined with other triggers generated by different aircraft components (possible alarms from the flight crew, data traffic anomaly, or alarm generated by one of the avionics components) to provide a better understanding of the situation to the monitoring crew.
General Framework for Meta-analysis of Rare Variants in Sequencing Association Studies

We propose a general statistical framework for meta-analysis of gene- or region-based multimarker rare variant association tests in sequencing association studies. In genome-wide association studies, single-marker meta-analysis has been widely used to increase statistical power by combining results via regression coefficients and standard errors from different studies. In analysis of rare variants in sequencing studies, region-based multimarker tests are often used to increase power. We propose meta-analysis methods for commonly used gene- or region-based rare variants tests, such as burden tests and variance component tests. Because estimation of regression coefficients of individual rare variants is often unstable or not feasible, the proposed method avoids this difficulty by calculating score statistics instead that only require fitting the null model for each study and then aggregating these score statistics across studies. Our proposed meta-analysis rare variant association tests are conducted based on study-specific summary statistics, specifically score statistics for each variant and between-variant covariance-type (linkage disequilibrium) relationship statistics for each gene or region. The proposed methods are able to incorporate different levels of heterogeneity of genetic effects across studies and are applicable to meta-analysis of multiple ancestry groups. We show that the proposed methods are essentially as powerful as joint analysis by directly pooling individual level genotype data. We conduct extensive simulations to evaluate the performance of our methods by varying levels of heterogeneity across studies, and we apply the proposed methods to meta-analysis of rare variant effects in a multicohort study of the genetics of blood lipid levels.
Temporal planning using subgoal partitioning and resolution in SGPlan

In this paper, we present the partitioning of mutual-exclusion (mutex) constraints in temporal planning problems and its implementation in the SGPlan4 planner. Based on the strong locality of mutex constraints observed in many benchmarks of the Fourth International Planning Competition (IPC4), we propose to partition the constraints of a planning problem into groups based on their subgoals. Constraint partitioning leads to significantly easier subproblems that are similar to the original problem and that can be efficiently solved by the same planner with some modifications to its objective function. We present a partition-and-resolve strategy that looks for locally optimal subplans in constraint-partitioned temporal planning subproblems and that resolves those inconsistent global constraints across the subproblems. We also discuss some implementation details of SGPlan4, which include the resolution of violated global constraints, techniques for handling producible resources, landmark analysis, path finding and optimization, search-space reduction, and modifications of Metric-FF when used as a basic planner in SGPlan4. Last, we show results on the sensitivity of each of these techniques in quality-time trade-offs and experimentally demonstrate that SGPlan4 is effective for solving the IPC3 and IPC4 benchmarks.
FPGA implementation of closed-loop control system for small-scale robot

Small robots can be beneficial to important applications such as civilian search and rescue and military surveillance, but their limited resources constrain their functionality and performance. To address this, a reconfigurable technique based on field-programmable gate arrays (FPGAs) may be applied, which has the potential for greater functionality and higher performance, but with smaller volume and lower power dissipation. This project investigates an FPGA-based PID motion control system for small, self-adaptive systems. For one channel control, parallel and serial architectures for the PID control algorithm are designed and implemented. Based on these one-channel designs, four architectures for multiple-channel control are proposed and two channel-level serial (CLS) architectures are designed and implemented. Functional correctness of all the designs was verified in motor control experiments, and area, speed, and power consumption were analyzed. The tradeoffs between the different designs are discussed in terms of area, power consumption, and execution time with respect to number of channels, sampling rate, and control clock frequency. The data gathered in this paper will be leveraged in future work to dynamically adapt the robot at run time
Cost-Effectiveness Analysis of Treatment Options for Acute Otitis Media

PURPOSE This study evaluated the costs and utility of observation and routine antibiotic treatment options for children with acute otitis media. METHODS The cost-effectiveness analysis was performed among children aged 6 months to 12 years seen in primary care offices. The interventions studied were watchful waiting as practiced in the Netherlands, delayed prescription, 5 days of amoxicillin, and 7 to 10 days of amoxicillin. The main outcome measure was cost per quality-adjusted life-year (QALY). RESULTS In the base case analysis, delayed prescription was the least costly option and 7 to 10 days of amoxicillin was the most effective. The incremental cost utility ratio (ICUR) of 7 to 10 days of amoxicillin compared with delayed prescription was $56,000 per QALY gained. Watchful waiting and 5 days of amoxicillin were inferior options. The results were sensitive to the rate of nonattendance in the delayed prescription strategy: when the rate was less than 23%, watchful waiting was the least costly option and delayed prescription was an inferior option. Probabilistic sensitivity analysis, in which all model variables were simultaneously varied, showed with 95% certainty that compared with delayed prescription, 7 to 10 days of amoxicillin had a 61% probability of having an ICUR of greater than $50,000 per QALY gained, and watchful waiting had a 23% probability of having an ICUR of less than $50,000 per QALY gained. CONCLUSIONS Economically, an approach to the treatment of acute otitis media with either an initial period of observation or routine treatment with amoxicillin is reasonable.
Globalization and Europeanization: A Challenge to French Politics

This article examines how globalization and Europeanization interact with each other, either in a centrifugal or in a centripetal way, to alter French politics. It analyzes how globalization has redefined domestic politics in France and it explores whether Europeanization has accelerated or hindered these transformations. It studies in turn the impact of globalization and Europeanization on power, preferences and institutions — three essential components of a country's domestic politics. The central argument is that globalization and Europeanization not only have transformed the nature of domestic politics, but are also becoming a new cleavage around which domestic politics are being structured.
Optimal design of self-damped lossy transmission lines for multichip modules

This paper presents a simple and robust method of designing the lossy-transmission-line interconnects for multichip modules (MCM). This method uses wire-sizing to meet the electrical damping criteria to propagate high-speed signals through unterminated lossy transmission lines on the substrates of multichip modules. Based on an improved scattering-parameters (S-parameters) macro-model of transmission lines, wire-sizing optimal design method relates the layout parameter (line width) and the transfer function (damping ratio, and natural undamped frequency) to the signal propagation delay. The optimal design method results in fast and stable signal propagation for single-source multi-receiver networks on multichip modules without using termination resistors. >
Oversampling PCM techniques and optimum noise shapers for quantizing a class of nonbandlimited signals

We consider the efficient quantization of a class of nonbandlimited signals, namely, the class of discrete-time signals that can be recovered from their decimated version. The signals are modeled as the output of a single FIR interpolation filter (single band model) or, more generally, as the sum of the outputs of L FIR interpolation filters (multiband model). These nonbandlimited signals are oversampled, and it is therefore reasonable to expect that we can reap the same benefits of well-known efficient A/D techniques that apply only to bandlimited signals. We first show that we can obtain a great reduction in the quantization noise variance due to the oversampled nature of the signals. We can achieve a substantial decrease in bit rate by appropriately decimating the signals and then quantizing them. To further increase the effective quantizer resolution, noise shaping is introduced by optimizing prefilters and postfilters around the quantizer. We start with a scalar time-invariant quantizer and study two important cases of linear time invariant (LTI) filters, namely, the case where the postfilter is the inverse of the prefilter and the more general case where the postfilter is independent from the prefilter. Closed form expressions for the optimum filters and average minimum mean square error are derived in each case for both the single band and multiband models. The class of noise shaping filters and quantizers is then enlarged to include linear periodically time varying (LPTV)/sub M/ filters and periodically time-varying quantizers of period M. We study two special cases in great detail.
Effect of registration on cyclical kinematic data

Given growing interest in functional data analysis (FDA) as a useful method for analyzing human movement data, it is critical to understand the effects of standard FDA procedures, including registration, on biomechanical analyses. Registration is used to reduce phase variability between curves while preserving the individual curve's shape and amplitude. The application of three methods available to assess registration could benefit those in the biomechanics community using FDA techniques: comparison of mean curves, comparison of average RMS values, and assessment of time-warping functions. Therefore, the present study has two purposes. First, the necessity of registration applied to cyclical data after time normalization is assessed. Second, we illustrate the three methods for evaluating registration effects. Masticatory jaw movements of 22 healthy adults (2 males, 21 females) were tracked while subjects chewed a gum-based pellet for 20 s. Motion data were captured at 60 Hz with two gen-locked video cameras. Individual chewing cycles were time normalized and then transformed into functional observations. Registration did not affect mean curves and warping functions were linear. Although registration decreased the RMS, indicating a decrease in inter-subject variability, the difference was not statistically significant. Together these results indicate that registration may not always be necessary for cyclical chewing data. An important contribution of this paper is the illustration of three methods for evaluating registration that are easy to apply and useful for judging whether the extra data manipulation is necessary.
Webmasters, web policies, and academic libraries: a survey

Purpose – The purpose of this paper is to gauge how university libraries are currently handling web policies as well as to see if the role of the library webmaster has evolved.Design/methodology/approach – A survey was created and an invitation to participate was sent to various electronic discussion lists. Most of the questions were quantitative and were coded to find trends in the responses.Findings – Most of the respondents either are reference librarians or webmasters, and they are mostly staff or faculty. As increasing numbers of resources become available electronically, university library web pages are going to continue to play an important role in academia. Survey responses indicate that most libraries (52 percent) have developed a web policy and 64 percent have formed a web advisory committee to maintain their web content. Responses also indicate the desire for further training in keeping up with the new technologies and the increased workload due to the time spent in maintaining web pages.Resear...
Long term clinical follow-up of atypical ductal hyperplasia and lobular carcinoma in situ in breast core needle biopsies

Atypical ductal hyperplasia (ADH) and lobular carcinoma in situ (LCIS) may be associated with a relatively high incidence of invasive carcinoma and ductal carcinoma in situ (DCIS) on immediate excision when found on core needle biopsy of the breast. However, the long term significance of ADH and LCIS in a breast core needle biopsy is not as well characterised. We reviewed the results of all breast core needle biopsies with a diagnosis of ADH or LCIS and immediate excision from the years 2000-2004, and correlated the results with long term clinical follow-up. Of 175 biopsies with ADH, 53 (30.3%) had carcinoma (8 invasive, and 45 DCIS) at the time of immediate re-excision. Of 69 biopsies with LCIS, three (4.3%) had carcinoma (2 invasive, and 1 DCIS) at the time of immediate re-excision. A total of 14 (11.5%) patients with ADH and benign re-excisions developed invasive carcinoma (12) or DCIS (2) on follow-up. A total of 17 (25.8%) patients with LCIS and benign re-excisions developed invasive carcinoma (13) or DCIS (4) on follow-up. The risk of invasive carcinoma or DCIS on immediate re-excision was significantly higher for women with ADH than LCIS (p<0.001). Women with LCIS developed significantly more invasive carcinomas and DCIS than women with ADH on long term follow-up (p=0.01). Compared to women with fibrocystic changes (FCC) on core needle biopsy, the risk of developing invasive carcinoma or DCIS was significantly higher for women with ADH and benign initial re-excisions (95% CI 1.092-7.297, p=0.03), and women with LCIS and benign re-excisions (95% CI 3.028-18.657, p<0.001). Overall, 67/175 (38.3%) women with ADH and 20/69 (29.0%) women with LCIS on core needle biopsy either had carcinoma at the time of the biopsy or later developed carcinoma. Significantly more women with LCIS developed invasive carcinoma or DCIS than women with ADH on long term follow-up. The relative risk for ADH and LCIS on core biopsy with a negative excision compared with FCC was similar to that reported in the literature (ADH 1-7×, LCIS 3-19×).
Developmental Distribution of the δ-Opioid Receptor in Mammalian Brains

The delta-opioid receptor (DOR) is widely distributed within the mammalian body, especially in the brain, and plays critical roles in a variety of physiological functions during development and in the adult. As compared to other opioid receptors such as mu- and kappa-opioid receptors, DOR is the slowest to develop and thus overall initially lags behind in early developmental abundance. Yet later in development, specifically near the well-examined time of approximately of 2 weeks postnatal in rats, DOR undergoes a rapid developmental process that ends in a distinctly heterogeneous distribution within the central nervous system. Fairly consistent across adult mammals is the formation of a decreasing rostral to caudal pattern of DOR protein and mRNA density with the highest levels detected in the superficial and deep layers of the cortex, caudate putamen and amygdala and much lower levels in the subcortical regions, such as most regions of the hippocampus, thalamus and hypothalamus. Additionally, DOR is encountered outside of the central nervous system in areas of wide variance, such as the immune and musculoskeletal systems (e.g., bone/bone marrow and loose connective tissue), the heart (on both myocardial cells and sparse individual nerve fibers), kidney, the gastrointestinal tract (muscle, mucosa and varicose fibers in the plexuses), and even in reproductive organs (testis and ovary). The broad and heterogeneous patterns of DOR distribution may imply high functional versatility, and likewise, the developmental changes of DOR could also be correlated to functional changes in various organs and different regions/cells within the same organ (e.g., rostral vs. caudal brain) from early life to the adult. This chapter aims to serve as a collation of the developmental distribution of DOR as well as its putative endogenous ligand, enkephalin, with particular emphasis on the central nervous system and encompasses their changes in both adult mammals as well as the chronological patterns throughout the stages of embryonic and postnatal development.
The BRC Canopy: An Important Player in Bone Remodeling

This Commentary highlights the article by Andersen et al, which describes structural changes in bone associated with increased bone resorption in osteoporotic post-menopausal women.
XXXIV: Benjamin Beresford, Literary Ambassador

Protege of the Duke of Bedford, tutor of the Queen of Prussia, minister of the Gospel in Moscow, and professor of English in Berlin—such are the more striking phases of the varied career ascribed to the Reverend Benjamin Beresford by his commentators, for whom the full measure of the man has remained obscured. Even recent recognition of his sterling service as pioneer literary intermediary between Germany and England has been vitiated by insufficient knowledge not only of the man himself but also of the publications by which he initiated and sustained for a quarter of a century English acquaintance with German lyric poetry. His translations of popular German songs accompanied by their original melodies have long since become rarities. Even during his lifetime the compiler of a musical lexicon expressed regret that he did not have Beresford's first collection at hand so that he might inform a future generation precisely which of various current compositions had been selected for the songs. As a matter of fact, this particular publication seems to have reached posterity in a unique copy. Succeeding publications suffered similar fortunes, many of them surviving in extremely scarce if not actually single copies.
Structure-Function Relationships in High Molecular Weight PAF-Acetylhydrolases from the Studies of a Microbial α/β Hydrolase

The α/β hydrolases constitute a ubiquitous family of enzymes found throughout the living world. Their relatively simple three-dimensional fold, made up of a central and predominantly parallel β-sheet, is flexible enough to provide a scaffold for a variety of active sites and substrate binding centers. Lipases and esterases are perhaps the most often listed members of this superfamily(1–4), followed by carboxypeptidases(5–7), and a selection of diverse enzymes such haloalkane dehalogenase(8), bromoperoxidase(9), and a hydroxinitrile lyase (10). It is becoming clear, that the α/β hydrolase fold is among the few highly favored by nature. Interestingly, so far no protein lacking catalytic activity has been found to have an α/β hydrolase fold.
Effects of grass maturity and legume substitution on large particle size reduction and small particle flow from the rumen of cattle.

Five ruminally and abomasally cannulated heifers (average weight 365 kg) were fed 6 kg/d of early (EOG) or late (LOG) maturity orchardgrass (OG) hay with or without replacement of EOG or LOG by 1.5 kg/d red clover hay (RC) in a 5 x 5 Latin square design. A fifth treatment, of LOG supplemented with 100 g/d casein (LOG + C), was used to evaluate the effect of supplemental protein. In situ fiber digestion, in vivo nutrient digestion and rate of passage from the rumen of large (retained on a 1.68-mm screen; labeled with La) and small (passed a 1.68-mm screen; labeled with Sm) EOG and LOG particles were determined in heifers fed these diets. Early maturity OG hay had 20% and 62%, respectively, greater (P less than .05) rates, and 61% and 73%, respectively, greater (P less than .05) extents of in situ NDF and ADF disappearance than LOG. Red clover substitution for OG increased (P less than .05) in situ extent of NDF disappearance by 6%. Early maturity OG large and small particles had 40% and 36%, respectively, greater (P less than .05) rates of passage than LOG. Large and small particle ruminal pool sizes were increased (P less than .05) by 115% and 33%, respectively, with LOG. Red clover substitution for OG increased (P less than .10) large and small particle output (kg/d) from the rumen by 15% and large particle rate of passage by 20%. Grass maturity may be affecting intake through rate of large particle size reduction and passage and small particle passage, although legume supplementation of OG may influence intake by increasing rate of large particle size reduction and passage.
Endothelial dysfunction in atherosclerosis

Endothelial regulation of vasomotor tone occurs largely via the release of nitric oxide or a closely related compound. This process is strikingly altered in a variety of disease states, and alterations of vasomotion may be responsible for the development of hypertension, altered tissue perfusion, and an enhanced propensity for vasoconstriction in several common disorders. In hypercholesterolemia and atherosclerosis, this alteration of vasomotor control occurs not only in larger vessels, but in the microcirculation. Explanations for impaired endothelium-dependent vascular relaxations in hypercholesterolemia include impairments in endothelial cell signal transduction, deficiencies in the substrate (arginine) for the enzyme nitric oxide synthase, alterations in the nitric oxide synthase enzyme or one of its co-factors, and excess destruction of nitric oxide by the superoxide anion. In this review, evidence for these alterations will be considered, potential interventions for restoring endothelium-dependent relaxations examined, and the possible impact of endothelial dysfunction in atherosclerosis considered.
Single Image Camera Calibration with Lenticular Arrays for Augmented Reality

We consider the problem of camera pose estimation for a scenario where the camera may have continuous and unknown changes in its focal length. Understanding frame by frame changes in camera focal length is vital to accurately estimating camera pose and vital to accurately rendering virtual objects in a scene with the correct perspective. However, most approaches to camera calibration require geometric constraints from many frames or the observation of a 3D calibration object — both of which may not be feasible in augmented reality settings. This paper introduces a calibration object based on a flat lenticular array that creates a color coded light-field whose observed color changes depending on the angle from which it is viewed. We derive an approach to estimate the focal length of the camera and the relative pose of an object from a single image. We characterize the performance of camera calibration across various focal lengths and camera models, and we demonstrate the advantages of the focal length estimation in rendering a virtual object in a video with constant zooming.
The Dynamic Rhetorical Structures of TESOL Conference Abstracts

In English Language Teaching (ELT), conferences have developed into valuable venues for both researchers and practitioners to learn and share their knowledge bases. Attending and presenting at academic conferences has become an important form of scholarship and professional development for researchers, in-service teachers, and pre-service teachers. In the field of ELT, the TESOL International Convention and Language Expo is a highly prestigious event but, for those wanting to present, highly competitive. The conference abstract is the basis of being granted permission to present at such conferences and, as such, is a critical gate-keeping genre. The goal of the present empirical study is to examine rhetorical features of successful conference abstracts (N=16) with the hope that the results will help teachers write their own conference proposals. Using genre analysis (Swales, 1990), the rhetorical structures of conference abstracts for TESOL 2014 were collected and annotated for rhetorical moves and steps following Halleck and Connor (2006). This detailed analysis uncovered rhetorical patterns common to all conference abstracts. Despite this, variations within proposals were identified in terms of number of moves and specific sequencing. Guidance and tips for novice writers are presented, and connections are made to local TESOL affiliates, such as BC TEAL.
Quantitative methods for studying hemostasis in zebrafish larvae

Hemostasis is a coordinated system through which blood is prevented from exiting a closed circulatory system. We have taken advantage of the zebrafish, an emerging model for the study of blood coagulation, and describe three techniques for quantitative analysis of primary and secondary hemostasis. Collectively, these three techniques comprise a toolset to aid in our understanding of hemostasis and pathological clotting.
SMYD proteins in immunity: dawning of a new era

In the past decade, the SMYD protein family has gradually become a center of research, thanking for its essential role in heart and muscle development and cancer development. However, because of such a role, the research scope for the SMYD protein family has been fairly stereotyped, its focus largely restricted to muscle and cancer. Initial studies of SMYD1 and SMYD3 were responsible for these biased research directions. SMYD1 was originally identified as a myogenic factor and regulated cardiomyocyte maturation and proper formation of the right ventricle [1]. SMYD3 was initially identified as an oncogene and regulated expression of cell-cycle genes in colorectal and hepatocellular carcinomas [2]. These findings have clearly indicated an essential role of SMYD1 and SMYD3 in cardiac muscle development and tumorigenesis respectively. Because of this, the research directions in SMYD proteins have been strongly influenced by these two studies, and much subsequent research has biased towards muscle and cancer.
A Self-Powered, Sub-nanosecond-Response Solution-Processed Hybrid Perovskite Photodetector for Time-Resolved Photoluminescence-Lifetime Detection

A self-powered,solution-processed perovskite photodetector with sub-nanosecond response time is presented. Eliminating charge trapping and removing the constraints from the resistance-capacitance constant increases the response speed, which enables them to be applied in a homemade, time-resolved photoluminescence system that successfully resolves the decay process of typical fluorescence and phosphorescent materials with a recombination lifetime from several nanoseconds to microseconds.
Modelling and Simulation Considerations of a Micro-chuck Mechanism

This paper addresses modelling and simulation considerations of chuck (friction grip) mechanism for high speed rotary cutting instrument shank (dental driller). The chuck (needle gripper) mechanism is embedded within a micro rotor-shaft casing. The shaft casing is a thin shell structure with dimension of 8 mm in length, 1.6 mm diameter and 0.5 mm shell thickness. High precision manufacturing is one of the dominant requirements in producing this dental equipment component. In the design for manufacturing case of such a micro mechanism, modelling and simulation become essential to ensure the precision requirements and the required chuck gripping force are satisfied. For this reason, accuracy of design analysis is vital. This work performs and compares stress analysis of micro-chuck gripping mechanism via both linear and non-linear theories. In addition, modelling and simulating the actual shank-gripping and releasing processes are performed by taking both plastic theory and contact mechanics into considerations. As a result, residual strain which degenerates the gripping force can be predicted. Moreover, the combination of non-linear finite element analysis and solid mechanics theory offers a promising environment for analyzing micro-chuck mechanism with precision manufacturing requirements.
Molecular basis for protection of ribosomal protein L4 from cellular degradation

Eukaryotic ribosome biogenesis requires the nuclear import of ∼80 nascent ribosomal proteins and the elimination of excess amounts by the cellular degradation machinery. Assembly chaperones recognize nascent unassembled ribosomal proteins and transport them together with karyopherins to their nuclear destination. We report the crystal structure of ribosomal protein L4 (RpL4) bound to its dedicated assembly chaperone of L4 (Acl4), revealing extensive interactions sequestering 70 exposed residues of the extended RpL4 loop. The observed molecular recognition fundamentally differs from canonical promiscuous chaperone–substrate interactions. We demonstrate that the eukaryote-specific RpL4 extension harbours overlapping binding sites for Acl4 and the nuclear transport factor Kap104, facilitating its continuous protection from the cellular degradation machinery. Thus, Acl4 serves a dual function to facilitate nuclear import and simultaneously protect unassembled RpL4 from the cellular degradation machinery.
Joint Inversion of Gravity and Magnetotelluric Data for the Depth-to-Basement Estimation

It is well known that both gravity and magnetolluric (MT) methods can be used for the depth-to-basement estimation due to the density and conductivity contrast between the sedimentary basin and the underlaid basement rocks. In this case, the primary targets for both methods are the interface between the basement and sedimenary rocks as well as the physical properties of the rocks (density and conductivity). The solution of this inverse problem is typically nonunique and unstable, especially for gravity inversion. In order to overcome this difficulty and provide a more robust solution, we have developed a method of joint inversion to recover both the depth to the basement and the physical properties of the sediments and basement using gravity and MT data simultaneously. The joint inversion algorithm is based on the regularized conjugate gradient method. To speed up the inversion, we use an effective forward modeling method based on the surface Cauchy-type integrals for the gravity field and the surface integral equation representations for the MT field, respectively. We demonstrate the effectiveness of the developed method using several realistic model studies.
Statistics on the space of trajectories for longitudinal data analysis

Statistical analysis of longitudinal data is a significant problem in Biomedical imaging applications. In the recent past, several researchers have developed mathematically rigorous methods based on differential geometry and statistics to tackle the problem of statistical analysis of longitudinal neuroimaging data. In this paper, we present a novel formulation of the longitudinal data analysis problem by identifying the structural changes over time (describing the trajectory of change) to a product Riemannian manifold endowed with a Riemannian metric and a probability measure. We present theoretical results showing that the maximum likelihood estimate of the mean and median of a Gaussian and Laplace distribution respectively on the product manifold yield the Frechet mean and median respectively. We then present efficient recursive estimators for these intrinsic parameters and use them in conjunction with a nearest neighbor (NN) classifier to classify MR brain scans (acquired from the publicly available OASIS database) of patients with and without dementia.
Testing the comparative effects of physical activity advice by humans vs. computers in underserved populations: The COMPASS trial design, methods, and baseline characteristics.

Abstract While physical inactivity is a key risk factor for a range of chronic diseases and conditions associated with aging, a significant proportion of midlife and older adults remain insufficiently active. This is particularly true for ethnic minority populations such as Latino adults for whom few culturally adapted programs have been developed and tested. The major objective of this 12-month cluster-randomized controlled trial is to test the comparative effectiveness of two linguistically and culturally adapted, community-based physical activity interventions with the potential for broad reach and translation. Ten local community centers serving a sizable number of Latino residents were randomized to receive one of two physical activity interventions. The Virtual Advisor program employs a computer-based embodied conversational agent named “Carmen” to deliver interactive, individually tailored physical activity advice and support. A similar intervention program is delivered by trained Peer Advisors. The target population consists of generally healthy, insufficiently active Latino adults ages 50 years and older living within proximity to a designated community center. The major outcomes are changes in walking and other forms of physical activity measured via self-report and accelerometry. Secondary outcomes include physical function and well-being variables. In addition to these outcome analyses, comparative cost analysis of the two programs, potential mediators of intervention success, and baseline moderators of intervention effects will be explored to better determine which subgroups do best with which type of intervention. Here we present the study design and methods, including recruitment strategies and yield as well as study baseline characteristics. Trial Registration : clinicaltrial.gov Identifier = NCT02111213 .
Output‐Based Performance Pay, Performance‐Support Bias, and the Racial Pay Gap within a Large Retail Stock Brokerage

We measure sources of racial inequality in stockbroker pay. Pay differences arise from sales differences. We measure the extent to which sales differences are due to performance‐support bias, whereby African American brokers receive weaker firm supports, or to forces outside the firm, including client access, selection, and consumer discrimination. Data on firm policies are matched to sales results. Data on self‐generation of accounts measure access to wealthy clients. Sales generated from accounts with sales histories show racial differences in sales arising from selection or consumer discrimination.
Employer knowledge of federal requirements for recording work-related injuries and illnesses: Implications for occupational injury surveillance data

Background Accuracy of the Bureau of Labor Statistics Survey of Occupational Injuries and Illnesses (SOII) data is dependent on employer compliance with workplace injury and illness recordkeeping requirements. Characterization of employer recordkeeping can inform efforts to improve the data. Methods We interviewed representative samples of SOII respondents from four states to identify common recordkeeping errors and to assess employer characteristics associated with limited knowledge of the recordkeeping requirements and non compliant practices. Results Less than half of the establishments required to maintain OSHA injury and illness records reported doing so. Few establishments knew to omit cases limited to diagnostic services (22%) and to count unscheduled weekend days as missed work (27%). No single state or establishment characteristic was consistently associated with better or worse record-keeping. Conclusion Many employers possess a limited understanding of workplace injury recordkeeping requirements, potentially leading them to over-report minor incidents, and under-report missed work cases.
Determination of Spatially Resolved Pore Size Information

Summary Nuclear Magnetic Resonance is a useful technique for measuring pore structures of samples which are saturated with a pore fluid. These NMR methods can be combined with NMR imaging techniques to give pore structure information as a function of position in the sample. We demonstrate the principle of such applications with an example using a porous glass. We are able to measure porosity in the sample with spatial resolution of approximately 50 μm. We have also demonstrated image discrimination based upon pore size.
Teacher Ratings of Attention Deficit Hyperactivity Disorder Symptoms in Hispanic Children

This study compared teacher's ratings of attention deficit hyperactivity disorder in groups of nonreferred Hispanic and non-Hispanic White children via the Teacher Report Form, the Attention Deficit Hyperactivity Disorder Scales—IV, and the Conners Abbreviated Teacher Rating Scale. A total of 61 non-Hispanic White teachers completed behavior ratings of 61 Hispanic and non-Hispanic White children between 6 and 11 years old. Significant differences were found between boys and girls, with girls showing fewer behavior problems and fewer hyperactive/inattentive symptoms compared to boys. In addition, Hispanics scored similar or lower than non-Hispanic Whites on multiple subscales measuring symptomatology related to attention deficit hyperactivity disorder and overall behavioral disorders. In no instance did Hispanic children score as more pathological than non-Hispanic White children. The need to consider the rater's ethnicity is discussed, and findings are explained in terms of childhood socialization patterns that might help to discern the behavior displayed by Hispanic children in classroom settings.
Reminiscences on the Life and Work of G.S.S. Ludford

As many of you know, Geoffrey Ludford had strong professional ties with France, and was chairman of the organizing committee for this meeting, so it is fitting that we should start by recalling something of the man and his life. This task has fallen to me since I probably knew him for as long and as well as anyone here. In fact, I knew him for nearly 22 years. We first met in the spring of 1965. I was working in Buffalo, Nev York, at Cornell Aeronautical Laboratory, owned at that time by Cornell University. Geoffrey was a professor at Cornell and that spring he periodically flew up from Ithaca to teach a graduate class on tensor analysis and the calculus of variations. It was a remarkably well-taught class in which the material was presented in an attractively pragmatic, no-nonsense style. It was not surprising then that when I went to Cornell University that fall to start my graduate studies, I asked him to be my advisor.
Enhancing implementation of measurement-based mental health care in primary care: a mixed-methods randomized effectiveness evaluation of implementation facilitation

Mental health care lags behind other forms of medical care in its reliance on subjective clinician assessment. Although routine use of standardized patient-reported outcome measures, measurement-based care (MBC), can improve patient outcomes and engagement, clinician efficiency, and, collaboration across care team members, full implementation of this complex practice change can be challenging. This study seeks to understand whether and how an intensive facilitation strategy can be effective in supporting the implementation of MBC. Implementation researchers partnering with US Department of Veterans Affairs (VA) leaders are conducting the study within the context of a national initiative to support MBC implementation throughout VA mental health services. This study will focus specifically on VA Primary Care-Mental Health Integration (PCMHI) programs. A mixed-methods, multiple case study design will include 12 PCMHI sites recruited from the 23 PCMHI programs that volunteered to participate in the VA national initiative. Guided by a study partnership panel, sites are clustered into similar groups using administrative metrics. Site pairs are recruited from within these groups. Within pairs, sites are randomized to the implementation facilitation strategy (external facilitation plus QI team) or standard VA national support. The implementation strategy provides an external facilitator and MBC experts who work with intervention sites to form a QI team, develop an implementation plan, and, identify and overcome barriers to implementation. The RE-AIM framework guides the evaluation of the implementation facilitation strategy which will utilize data from administrative, medical record, and primary qualitative and quantitative sources. Guided by the iPARIHS framework and using a mixed methods approach, we will also examine factors associated with implementation success. Finally, we will explore whether implementation of MBC increases primary care team communication and function related to the care of mental health conditions. MBC has significant potential to improve mental health care but it represents a major change in practice. Understanding factors that can support MBC implementation is essential to attaining its potential benefits and spreading these benefits across the health care system.