cssi/SciSciGPT-SciSciNet huggingface dataset:
BLACK/CLAD: a layout synthesis tool for combinational blocks from behavioral HDL descriptions

The first of two loosely coupled CAD tools is presented. BLACK is a synthesis program which generates a topological transistor netlist from a behavioral description written in VHDL, Verilog, truth lab, or Boolean equations. The netlist produced by BLACK is then used by the second tool to produce full custom layouts. The second tool, CLAD, is a layout program which uses simulated annealing to optimize the placement of the different transistor groups. The BLACK and CLAD synthesis system accepts behavioral hardware description language descriptions or transistor netlists as inputs, and generates full-custom two-dimensional layouts rather than standard cell netlists. An example of synthesizing a Muller C, an asynchronous sequential circuit, is given. >
The hysterical personality. An attempt at validation with the MMPI.

We attempted to validate the DSM-II diagnosis of hysterical personality and the depression often experienced by such patients by comparing mean Minnesota Multiphasic Personality Inventory (MMPI) scores of hysterical personality patients with those of paranoid schizophrenic patients and a group with mixed psychiatric diagnoses. Index patients had significantly higher scores than either control group and could be distinguished on individual scales from the paranoid schizophrenics. However, the mean MMPI profile of hysterical personalities was similar to that of depressed controls. Therefore, the MMPI alone could not differentiate these two groups nor could it confirm or refute the validity of the diagnostic concept of hysterical personality, but it did support the clinical observation that depression is a major risk for individuals given this diagnosis and that the experience of depression by these patients is genuine.
Use of sequential teboroxime imaging for the detection of coronary artery occlusion and reperfusion in ischemic and infarcted myocardium

Abstract Nine Yorkshire pigs underwent coronary artery occlusion followed by 2 hours of reperfusion. In five pigs (group A) the occlusion time was 15 minutes and in four pigs (group B) the occlusion time was 1 hour. Teboroxime was administered and images were acquired at baseline, and following occlusion and reperfusion. Infarct size was determined by triphenyl tetrazolium staining. Normalized regional myocardial blood flow, as determined by radio-labeled microspheres, was 0.26 ± 0.09 following occlusion and 0.83 ± 0.07 following reperfusion ( p p p
Primary pancreatic lymphoma diagnosed by endoscopic ultrasound

Primary pancreatic lymphoma (PPL) which originates and remains localized to pancreas is very rare (Pancreas 7:1118, 1992). Without histelogic examination, it cannot be differentiated from pancreatic carcinoma; the differentiation is important as treatment and prognosis are different. US, CAT and ERCP findings are not pathognomonic. Rarer still is PPL presenting as acute pancreatitis (AP) (Gastroenteral Clin Biol 23:528, 1999). We present a case of PPL which presented as AP and was diagnosed by EUS |[plus]| FNA.
Aspirin causes in vivo synthesis of type i collagen by atrophic articular cartilage

We have previously shown that aspirin, when fed to dogs daily for 6 weeks in amounts sufficient to maintain serum levels at 20–25 mg/dl, worsens the degeneration of knee cartilage caused by immobilization of the limb in a cast. Thus, there is a greater decrease in proteoglycan content and synthesis and an increase in proteoglycan extractability in cartilage from immobilized limbs of dogs fed aspirin, compared with dogs not fed aspirin. The present study was designed to examine whether phenotypic changes in cartilage collagen also occur under these conditions. Cartilage samples from the immobilized and contralateral control limbs of 3 dogs killed after 6 weeks of casting showed no reaction with specific fluorescein-labeled rabbit antibody to human type I collagen. However, if dogs were fed aspirin during the casting period, cartilage from immobilized limbs showed marked staining of the chondrocytes with antibody to type I collagen and weak fluorescence of the interterritorial matrix. In 4 dogs the cast was removed after 6 weeks: 2 were allowed to ambulate in a pen for 3 weeks and 2 were subjected to treadmill running for 3 weeks after cast removal. The animals were maintained on aspirin for the entire 9 weeks. In all 4 dogs, cartilage from the previously immobilized limbs showed marked fluorescence for type I collagen. Cartilage from the non-immobilized knees, regardless of whether the dog received aspirin, did not react with the antibody, showing that the presence of type I collagen was not due to aspirin feeding alone.
Constraining the Active Galactic Nucleus Contribution in a Multiwavelength Study of Seyfert Galaxies

We have studied the relationship between the high- and low-ionization [O IV] (lambda)25.89 microns, [Ne III] (lambda)15.56 microns, and [Ne II] (lambda)12.81 microns emission lines with the aim of constraining the active galactic nuclei (AGNs) and star formation contributions for a sample of 103 Seyfert galaxies.We use the [O IV] and [Ne II] emission as tracers for the AGN power and star formation to investigate the ionization state of the emission-line gas.We find that Seyfert 2 galaxies have, on average, lower [O IV]/[Ne II] ratios than Seyfert 1 galaxies. This result suggests two possible scenarios: (1) Seyfert 2 galaxies have intrinsically weaker AGNs, or (2) Seyfert 2 galaxies have relatively higher star formation rates than Seyfert 1 galaxies. We estimate the fraction of [Ne II] directly associated with the AGNs and find that Seyfert 2 galaxies have a larger contribution from star formation, by a factor of approx.1.5 on average, than what is found in Seyfert 1 galaxies. Using the stellar component of [Ne II] as a tracer of the current star formation, we found similar star formation rates in Seyfert 1 and Seyfert 2 galaxies.We examined the mid- and far-infrared continua and found that [Ne II] is well correlated with the continuum luminosity at 60 microns and that both [Ne III] and [O IV] are better correlated with the 25 micron luminosities than with the continuum at longer wavelengths, suggesting that the mid-infrared continuum luminosity is dominated by the AGN, while the far-infrared luminosity is dominated by star formation. Overall, these results test the unified model of AGNs and suggest that the differences between Seyfert galaxies cannot be solely due to viewing angle dependence.
Gentrification and the Racialized Geography of Home Equity

This article presents an exploration of how gentrification is restructuring racial disparity in home equity building across several U.S. metropolitan areas. I reveal some ways in which gentrification is affecting the relative wealth levels of Black and Latino homeowners, a historically marginalized segment of the housing market. The most common trajectory involves a relatively high concentration of Black and Latino homeowners at the onset of gentrification, increased median levels of home equity for these homeowners as gentrification proceeds, and a relatively high attrition to other parts of the metropolitan area over time. The results suggest that although Black and Latino homeowners can reap financial benefit from gentrification, gentrification encourages net migration toward other parts of the metropolitan area where home equity gains are lower.
Rainfall – Ocean Faunal Interactions, Carteret County, North Carolina

Abstract Rainfall data collected at the Institute of Marine Sciences (IMS) for the years 1983–2011 varied between 0.5 1 (12.9 mm) and 0.75 (19.1 mm) inches/day/yr. Storms, hurricanes and natural events greatly influenced the data. Hurricanes, run off , flooding and El Nino, and La Nina events influenced increases and decreases in precipitation pre-1990 and post-1990. Shark, finfish and shrimp catches varied in response to storm effects on the nearby river and ocean water temperatures. Significant statistical differences existed between rainfall and shark catches.
Use of target protector morpholinos to analyze the physiological roles of specific miRNA-mRNA pairs in vivo

MicroRNAs (miRNAs) regulate gene expression by pairing with complementary sequences in the 3' untranslated regions (UTRs) of transcripts. Although the molecular mechanism underlying miRNA biogenesis and activity is becoming better understood, determining the physiological role of the interaction of an miRNA with its target remains a challenge. A number of methods have been developed to inhibit individual miRNAs, but it can be difficult to determine which specific targets are responsible for any observed phenotypes. To address this problem, we use target protector (TP) morpholinos that interfere with a single miRNA-mRNA pair by binding specifically to the miRNA target sequence in the 3' UTR. In this protocol, we detail the steps for identifying miRNA targets, validating their regulation and using TPs to interrogate their function in zebrafish. Depending on the biological context, this set of experiments can be completed in 6-8 weeks.
The effect of the target structure and composition on the ejection and transport of polymer molecules and carbon nanotubes in matrix-assisted pulsed laser evaporation

Matrix-assisted pulsed laser evaporation (MAPLE) is a prominent member of a broad and expanding class of laser-driven deposition techniques where a matrix of volatile molecules absorbs laser irradiation and provides the driving force for the ejection and transport of the material to be deposited. The mechanisms of MAPLE are investigated in coarse-grained molecular dynamic simulations focused on establishing the physical regimes and limits of the molecular transfer from targets with different structures and compositions. The systems considered in the simulations include dilute solutions of polymer molecules and individual carbon nanotubes (CNTs), as well as continuous networks of carbon nanotubes impregnated with solvent. The polymer molecules and nanotubes are found to be ejected only in the ablation regime and are incorporated into matrix-polymer droplets generated in the process of the explosive disintegration of the overheated matrix. The ejection and deposition of droplets explain the experimental observations of complex surface morphologies in films deposited by MAPLE. In simulations performed for MAPLE targets loaded with CNTs, the ejection of individual nanotubes, CNT bundles, and tangles with sizes comparable or even exceeding the laser penetration depth is observed. The ejected CNTs align along the flow direction in the matrix plume and tend to agglomerate into bundles at the initial stage of the ablation plume expansion. In a large-scale simulation performed for a target containing a network of interconnected CNT bundles, a large tangle of CNT bundles with the total mass of 50 MDa is separated from the continuous network and entrained with the matrix plume. No significant splitting and thinning of CNT bundles in the ejection process is observed in the simulations, suggesting that fragile structural elements or molecular agglomerates with complex secondary structures may be transferred and deposited to the substrate with the MAPLE technique.
Desmosomes from a structural perspective

Desmosomes are cell-cell junctions responsible for maintaining the structural integrity of tissues by resisting shear forces. Defects result in diseases of mechanically challenged tissues such as skin and heart. The architectural design represents the key to understanding the strength and durability inherent to desmosomes. A number of different proteins contribute to this architecture, and X-ray crystallography has made considerable progress in defining the atomic structure of various isolated domains. Electron tomography has been used to determine the three-dimensional structure of intact desmosomes in situ. By combining information from X-ray crystallography, cell and molecular biology and electron tomography, it should ultimately be possible to deduce the specific protein interactions that define the mechanical properties of this important adhesive junction.
Retrieving the Moral Significance of Deserving for Protestant Ethics: Calvin's Commentaries on Personal Desert in Economic Exchange

Whether modern Protestant thinkers claim a direct inheritance to specific Reformers or not, they stand within a tradition that reveres grace as the preeminent moral standard, often at the expense of considerations of merit or desert. John Milbank and Kathryn Tanner exemplify such stances in their theological visions of economic exchange. I critique their positions by retrieving from John Calvin a more nuanced understanding of his outlook on deservingness, especially as it pertains to economic justice, and then suggest a concept of desert that works concomitantly with grace to overcome the frequent rejection or neglect of the standard in Protestant ethics.
Secure localization with phantom node detection

In an adversarial environment, various kinds of attacks become possible if malicious nodes could claim fake locations that are different from their physical locations. In this paper, we propose a secure localization mechanism that detects existence of these nodes, termed as phantom nodes, without relying on any trusted entities, an approach significantly different from the existing ones. The proposed mechanism enjoys a set of nice features. First, it does not have any central point of attack. All nodes play the role of verifier, by generating local map, i.e. a view constructed based on ranging information from its neighbors. Second, this distributed and localized construction results in strong robustness against adversaries: even when the number of phantom nodes is greater than that of honest nodes, we can filter out most of the phantom nodes. Our analytical results as well as simulations under realistic noisy settings demonstrate that the proposed mechanism is effective in the presence of a large number of phantom nodes.
Compiler and software distributed shared memory support for irregular applications

We investigate the use of a software distributed shared memory (DSM) layer to support irregular computations on distributed memory machines. Software DSM supports irregular computation through demand fetching of data in response to memory access faults. With the addition of a very limited form of compiler support, namely the identification of the section of the indirection array accessed by each processor, many of these on-demand page fetches can be aggregated into a single message, and prefetched prior to the access fault.We have measured the performance of this approach for two irregular applications, moldyn and nbf, using the Tread-Marks DSM system on an 8-processor IBM SP2. We find that it has similar performance to the inspector-executor method supported by the CHAOS run-time library, while requiring much simpler compile-time support. For moldyn, it is up to 23% faster than CHAOS, depending on the input problem's characteristics; and for nbf, it is no worse than 14% slower. If we include the execution time of the inspector, the software DSM-based approach is always faster than CHAOS. The advantage of this approach increases as the frequency of changes to the indirection array increases. The disadvantage of this approach is the potential for false sharing overhead when the data set is small or has poor spatial locality.
Exploiting an antivirus interface

We propose a technique for defeating signature-based malware detectors by exploiting information disclosed by antivirus interfaces. This information is leveraged to reverse engineer relevant details of the detector's underlying signature database, revealing binary obfuscations that suffice to conceal malware from the detector. Experiments with real malware and antivirus interfaces on Windows operating systems justify the effectiveness of our approach.
Characterization and inhibition of polyphenol oxidase from pears (Pyrus communis L. cv. Bosc and Red)

Red pears had higher PPO activity, total phenolics and chlorogenic acid concentration than Bosc pears. PPO activity, and phenolics both decreased in fruits held at room temperature. pH and temperature optima for Bosc and Red pears PPOs were 5.0 and 5.5, and 20 and 23 C, respectively. 4-Methylcatechol, catechol and dopamine were good substrates for PPO from both pear cultivars; however, no activity was observed with any of the mono-hydroxy substrates studied. Higher Km and lower Vmax values were observed for Bosc pear PPO. Heating at 75 C for 30 min completely inactivated the enzyme from both cultivars. Heating at 55 and 65 C for the same duration resulted in partial inactivation (45-60%) of this enzyme. Ascorbic acid, L-cysteine, sodium metabisulfite and thiourea effectively inhibited browning due to pear PPOs.
Mining paths and transactions data to improve allocating commodity shelves in supermarket

How to deploy commodities for sale in different shelves in a supermarket in order to obtain better benefit for merchants with considering convenience for customers is an important topic in the retail area. In this paper, we present a new method for allocating commodity shelves in supermarket based on customers' shopping paths and transactions data mining. Therein, customers' shopping paths data can be obtained by shopping cart or basket, on which RFID (Radio Frequency Identification) tags located. And shopping transaction data can be obtained from POS (Point of Sales) machine. Through integrating and mining the frequent paths data and transactions data, See-Buy Rate, which refers to an approximate probability to purchase this commodity for customers when they see this commodity, can be calculated for each commodity. Based on See-Buy Rate, we build benefit optimization model to obtain the optimal allocating solution with considering the profit, sales volume, and purchase probability of the commodity. At last, one computation example is illustrated to show how to apply this method to practice.
Electrical properties of yttrium sesquisulfide (Y2S3) mechanically alloyed with copper, boron, and aluminum

Abstract The electrical resistivity, thermoelectric power (Seebeck coefficient) and Hall effects have been measured for (Y2S3)1−xX3 compounds with the δ-monoclinic structure (where X = Cu. B or Al and y = 0.05 for Cu and B, and 0.025 ≤ y ≤ 0.075 for Al) in order to determine their potential as high temperature (300–1000°C) thermoelectric materials. The Cu- and B-doped Y2S3 are insulators. The Al-doped Y2S3 behaves as a metastable degenerate semiconductor with itinerant conduction. The room temperature electrical resistivity decreases as the Al doping level increases, while the Seebeck coefficient remains constants at ca.400 μV eC1. These materials, however, become insulators after a 2 week heat treatment at 1000°C or higher. Both the electrical resistivity and Seebeck coefficient increased with increasing temperature, and exhibited lower values during the cool down run to room temperature. These data suggest that the (Y2S3)1, Al, alloys are in a metastable state in which the Al atoms occupy the interstitial sites of the Y2S3 lattice, where it acts as a current carrier donor. When heated, the Al atoms diffuse out of the lattice and no longer contribute to the electrical conductivity, thus making the alloy an insulator. The maximum value of the power factor was 0.6 μW cm 1 °C 2, and decreased with increasing temperature. The results of this study indicate that Cu-, B-, and Al-doped Y2S3 are not useful as high temperature thermoelectric materials.
Modelling the Disruptive Effects of Irrelevant Speech on Order Information

The feature model (Nairne, 1990) is extended to include order information by incorporating aspects of Estes' (1972, 1997) perturbation theory. Order information is encoded with other cues in primary memory and precision is gradually lost due to drift along the appropriate dimension. Recall begins with the cue whose positional uncertainty gradient indicates it was in the first position with the highest probability. Order errors occur primarily because cues can ''perturb'' to adjacent positions: Although the appropriate secondary memory target is sampled, it is sampled out of order. However, cues that have not perturbed can also sample an incorrect secondary memory item, which is then recalled out of order. Thus, both order errors and item errors can give rise to recalling an item from the list in an incorrect position. A simulation shows that with the addition of the perturbation mechanism, the feature model can produce the appropriate order error gradients for short and long words recalled in quiet, accom...
Perceptions of a Wireless Network

AbstractRecently, the power and affordability of portable computers and wireless networking have begun a trend toward the development of computer labs at many universities based on this technology. This article outlines the perceptions of students and instructors toward portable computing coupled to wireless networking in an educational setting. Both students and instructors responded positively to this computer environment and provided evidence that many learning outcomes can be enhanced by the presence of such an environment.
Observation Methodology and Supervisory Behavior

Summary A direct observation technique was used to study the job of the production foreman. Approximately 32,000 observations on 85 foremen in four production departments of two widely separated automotive assembly plants were gathered. Criterion data were obtained on each of the foremen. From 24 criterion measures studied, eight (4 objective; 4 subjective) were selected for use in this analysis. A chi-square analysis of the data showed differences which were significant but did not stand up in cross-validation (first half vs. second half). Also, the information obtained was not sufficiently novel to justify its use over less expensive interview and questionnaire techniques. Discussion related to the crucial importance in supervision of the intellectual and abstract behaviors which do not lend themselves to direct observation. The broad claims made by proponents of direct observations as an appropriate measure of supervisory behavior do not appear justified by the results of this study.
Developmental role of static, dynamic, and contextual cues in speech perception.

The purpose of the current study was to examine the role of syllable duration context as well as static and dynamic acoustic properties in child and adult speech perception. Ten adults and eleven 4–5-year-old children identified a syllable as [ba] or [wa] (stop-glide contrast) in 3 conditions differing in synthetic continua. The 1st condition tested the potential existence of the syllable duration effect in young children, whereas the 2nd and 3rd conditions examined the developmental role of static and dynamic cues, respectively, as related to syllable duration context effects. In the 1st condition, the 1st and 2nd formant transition duration of stimuli varied from those appropriate for [ba] to those appropriate for [wa]. For the 2nd condition, a static burst was added to Condition 1 stimuli. For the 3rd condition, the dynamic transition frequency and transition duration for the first 3 formants varied as appropriate for [ba] and [wa]. In each condition, 3 syllable context durations of 105 ms, 170 ms, and...
Quinolinic acid stimulates luteinizing hormone secretion in female rats: evidence for involvement of N-methyl-D-aspartate-preferring receptors

Pharmacological evidence suggests that endogenous excitatory amino acid neurotransmitters stimulate luteinizing hormone (LH) secretion in neonatal and adult rats. Recent studies have identified quinolinic acid (QUIN), an endogenous brain and peripheral metabolite of tryptophan, as a potent agonist at N-methyl-D-aspartate (NMDA)-preferring excitatory amino acid receptors. The present studies examined whether QUIN alters LH secretion in ovariectomized, estradiol-primed rats and whether such effects are mediated by specific amino acid receptor subtypes. In one experiment, animals received intracisternal injections of either quinolinic acid, N-methyl-DL-aspartate (NMA), aspartate (ASP), quisqualic acid (QA), or monosodium glutamate (GLU) five minutes prior to decapitation. In a second study, animals receiving central QUIN or NMA were treated simultaneously with either 2-amino-7-phosphonoheptanoic acid (APH) or kynurenic acid (KYA), both antagonists of NMDA-preferring receptors, or the quisqualate antagonist, glutamate diethyl ester (GDEE). Serum LH concentrations were measured by radioimmunoassay. Intracisternal administration of either QUIN or NMA resulted in an acute, dose-dependent increase of serum LH concentrations. Coadministration of APH blocked the effects of QUIN and NMA. QUIN stimulation of LH was also blocked by KYA, but not GDEE. Neither GLU nor ASP increased LH release, but QA did produce a small, significant elevation of LH. Light microscopic evaluation of brains showed no morphologic disturbance resulting from administration of these agents. The present results suggest that QUIN, or other endogenous ligands of NMDA-preferring receptors, may participate in the regulation of LH secretion in the adult female rat.
Review: Comprehensive treatments for youth comorbidity – evidence‐guided approaches to a complicated problem

Background: Evidence-based treatments (EBTs) with a single-disorder focus have improved the potential for youth mental health care, yet may be an imperfect fit to clinical care settings where diagnostic comorbidity and co-occurring problems are commonplace. Most EBTs were developed to treat one diagnosis or problem (or a small homogenous cluster), but most clinically referred youths present with multiple disorders and problems. Findings: Three emerging approaches may help address the comorbidity that is so common in treated youths. Conceptually unified treatments target presumed causal and maintaining factors that are shared among more than one disorder or problem area; preliminary open trials and case studies show promising results. Modular protocols combine the ‘practice elements’ that commonly appear in separate single-disorder EBTs and repackage them into coordinated delivery systems; one modular protocol, MATCH, has produced positive findings in a randomized effectiveness trial. Monitoring and Feedback Systems (MFSs) provide real-time data on client progress to inform clinical decision-making, encompassing comorbid and co-occurring problems; one study shows beneficial effects in everyday practice with diverse youth problems. Conclusions: All three approaches – conceptually unified, modular, and MFS – can be strengthened by increased research attention to treatment integrity, clinician user-appeal, design simplicity, and the infrastructure necessary for successful implementation. Key Practitioner Message  Most evidence-based treatments (EBTs) for youths were developed to treat a single target disorder or problem domain, or a homogenous cluster, but most clinically referred youths present with multiple disorders and problems.  When client comorbidity is not directly addressed by EBTs, clinicians may be left without evidence-based guidance. To address this gap, three approaches warrant attention.  Unified manuals that address presumed causal and maintaining factors of more than one disorder may be of value, particularly for problems with shared theoretical and empirical literatures.  Modular approaches to EBTs may be an effective way for clinicians to treat multi-problem and comorbid youths, even those with conceptually distinct conditions, and one approach, MATCH, has been found to be effective in a randomized trial.  Monitoring and feedback systems provide real-time case-specific evidence that can guide the clinical decision-making required in treating comorbid clients, regardless of the treatment approach employed.
General or Expenditure Rationing

I. Introduction, 418. — II. Objectives of rationing, 419. — III. The nature and advantages of General Rationing, 420. — IV. General Rationing and the control of inflation, 422. — V. The effect on production, 424. — VI. The effect on morale, 430. — VII. Administrative problems, 431. — VIII. Problems in the introduction of General Rationing, 432. — IX. The problem of incentives, 433. — X. Conclusion, 434.
Generalized plus-constructions and fundamental groups

Any generalized homology theory induces a generalized plus construction. We describe the effect of these plus-constructions upon fundamental groups. As a special case, we show that the generalized plus-construction associated to complex K-theory induces the same map on fundamental groups as Quillen's plus-construction with respect to the perfect radical. To do this, we identify Quillen's plus-construction with the Bousfield nullification of a space with respect to the wedge of all countable H∗(−;Z)-acyclic spaces.
Abstract 2615: Amplification and/or high expression of Myc family genes sensitizes tumor cells to aurora kinase inhibitors

The identification of patient populations predicted to derive clinical benefit from systemic treatment regimens is of critical importance for development of targeted therapies. Collective clinical data available for the Aurora kinase inhibitor class of targeted therapies has indicated that broad single agent clinical activity is not readily apparent. We screened a panel of established lung (mostly non-small cell) and colon cell lines for growth inhibitory sensitivity to PF-03814735, an Aurora family kinase inhibitor, revealing a potential correlation with Myc family amplification or expression. The Aurora kinases A and B have been shown to be functionally linked with Myc family oncoproteins in a number of tumor types. Myc family gene amplification events have been reported in about 30% of small cell lung cancer (SCLC) primary tumors and around 50% of cell lines established from SCLC. We next screened a panel of around 20 SCLC lines for sensitivity to PF-03814735 and its relationship to Myc family gene copy number and gene expression levels. Sensitivity to PF-03814735 in vitro was strongly correlated with amplification events in at least one of the Myc family genes (c-Myc, L-Myc, N-Myc) as well as mRNA expression levels of those genes. Myc family expression demonstrated a significant correlation with gene copy number. Follow up studies to evaluate antitumor efficacy in two SCLC xenograft models, H82 (c-Myc) and H69 (N-Myc), indicated significant tumor growth inhibition by PF-03814735. However, the SCLC models were not appreciably more sensitive to PF-03814735 than several non-Myc amplified tumors studied previously (HCT-116, COLO-205, MDA-MB-231) indicating that further study of optimal dose schedule and/or the molecular basis of sensitivity is warranted. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2615.
Smart charging architecture for between a plug-in electrical vehicle (PEV) and a smart home

In a smart grid, customers can not only use energy, but also produce it by using smart meters with battery energy storage systems in smart homes or buildings. The expected increased penetration rate of electrical vehicles, optimal control of charging algorithm will reduce energy consumption in smart grid. In this paper, we propose optimal charging architecture between a smart home and a plug-in electrical vehicle. This solution architecture is expected to optimize energy and power sharing between a plug-in electrical vehicle and a home with minimal costs with demand variability. It also reflects battery energy storage system's state of charge to make flat demand response schedule.
DYNAMICS OF NORMAL AND DISEASED CARDIAC VALVES.

Abstract The function of normal and diseased cardiac valves was studied with a modified McMillan cardiac pulse duplicator. Opening of normal mitral and tricuspid valves depends on flexible valve leaflets and intact commissures; closure depends on sufficient leaflet substance to occlude the valve orifice, flexibility of the leaflet edges to permit fluid-tight seal, and intact chordae tendineae to prevent leaflet eversion. Competent closure of the tricuspid valve necessitates contraction of the myocardium surrounding the valve annulus. In mitral stenosis, fibrous thickening and retraction of the leaflets, and fusion of the commissures are the basic lesions; they vary from mild to moderate commissural fusion in some hearts to severe commissural fusion with thick, inflexible, and calcified leaflets in others. Associated fusion, shortening, and rigidity of the chordae tendineae further reduce leaflet mobility. Mitral valvuloplasty may significantly increase the area of the valve orifice, without significantly increasing any insufficiency already present. Opening of the semilunar valves depends on flexible cusps and intact commissures. Adequate closure depends on sufficient cusp substance, and on the cup-shape of the cusps which permits them to support high pressures without prolapsing. Aortic stenosis results from commissural fusion and/or from calcific deposits within the sinuses of Valsalva. Either splitting of the commissures or removal of the calcific deposits corrected this type of stenosis without leading to insufficiency. Aortic stenosis and insufficiency result form fusion and retraction of the valve cusps, with obliteration of the commissures and of the sinuses of Valsalva. Careful splitting of the residual commissures permitted the cusps to abut during diastole, and insufficiency was not increased. Aortic insufficiency commonly results from loss of cusp substance, aggravated by sagging of the cusps and by dilatation of the aortic ring. The use of aortic prosthetic valves appears to be the most promising method for correction of this lesion.
Comment on 'Preignition products from propellants at simulated high altitude conditions'

Engine pressure spiking restart preignition products, determining hydrazine nitrate and dinitrate presence by spectrum analysis
Some topics in quantum imaging

This talk will give an overview of quantum imaging which investigates ultimate performance limits in optical imaging imposed by the quantum nature of the light. I will discuss several topics of quantum imaging such as noiseless image amplification, quantum limits of super-resolution, etc.
Regional analysis of tertiary volcanic calderas (Western U.S.) using landsat thematic mapper imagery

The Landsat Thematic Mapper (TM) imagery of the Basin and Range province of southern Nevada was analyzed to identify and map volcanic rock assemblages at three Tertiary calderas. It was found that the longer-wavelength visible and the NIR TM Bands 3, 5, and 7 provide more effective lithologic discrimination than the shorter-wavelength bands, due partly to deeper penetration of the longer-wavelength bands, resulting in more lithologically driven radiances. Shorter-wavelength TM Bands 1 and 2 are affected more by surficial weathering products including desert varnish which may or may not provide an indirect link to lithologic identity. Guidelines for lithologic analysis of volcanic terrains using Landsat TM imagery are outlined.
Solar System: An incredible likeness of being

Earth and the Moon share many puzzling chemical similarities. New analyses show that the last planet-sized body to hit Earth could have been similar enough to Earth to yield a Moon with an Earth-like composition. See Letter p.212 The Moon is thought to have formed mainly from material within a giant impactor that struck the proto-Earth, so it seems odd that the compositions of the Moon and Earth are so similar, given the differing composition of other Solar System bodies. Alessandra Mastrobuono-Battisti et al. track the feeding zones of growing planets in a suite of computational simulations of planetary accretion and find that different planets formed in the same simulation have distinct compositions, but the compositions of giant impactors are more similar to the planets they impact. A significant fraction of planet–impactor pairs have virtually identical compositions. The authors conclude that the similarity in composition between the Earth and Moon could be a natural consequence of a late giant impact.
A consideration of animal models used for study of influenza virus inhibitors

Abstract When an animal model is sought for the study of potential anti-influenza virus agents, investigators commonly turn to the mouse or ferret, which can be experimentally infected by the virus. The ferret will develop febrile illness when infected with influenza A viruses and has successfully been used for study of influenza virus inhibitors. Evaluation parameters commonly include temperature elevation, virus recovery from respiratory tissues and nasal washes and pneumonia-associated mortality. The mouse is often chosen because of its lower cost, ready availability, and ease of handling. Disease parameters using this model include pneumonia-associated mortality, decline in arterial oxygen saturation, lung consolidation, lung virus titers, host weight loss, and increase in serum (α1-acid glycoprotein. Antiviral data using both animal models are usually comparable; based on studies with amantadine, rimantadine, zanamivir, and oseltamivir, they are predictive for efficacy in the clinic. Rapid development of viral resistance to amantadine and rimantadine and a failure to observe resistance development to the influenza neuraminidase inhibitors has been demonstrated in the murine model. Immunocompromised mice have been used in studies with the latter compounds to demonstrate that their disease-inhibitory effect is not dependent upon the host's immune system. The concepts in the utilization of animal models for study of antiviral drugs will be reviewed.
Interactive Data Analysis For Astronomy Shuttle Experiments At Goddard Space Flight Center

The eye as an efficient selection device for determining what is important in astronomical imagery can be greatly aided by the computer. A suitable facility, called the Interactive Astronomical Data Analysis Facility (IADAF), has been developed for the display and analysis of astronomical imagery by the Laboratory for Astronomy and Solar Physics. The Laboratory for Astronomy and Solar Physics currently has approval to fly two experiments on Spacelab. The Solar Extreme Ultraviolet Telescope (SEUTS) is to be used for the study of several fundamental problems of solar physics. The Ultraviolet Image Telescope for Astronomical Investigations (UIT) is to provide direct imagery of selected fields of view throughout the sky. A description is given of IADAF, taking into account its 16-bit computer and the COMTAL image processing display system. The use of IADAF by SEUTS and UIT is discussed.
Attenuation of acoustic and tactile startle responses of vitamin B-6 deficient rats

Vitamin B-6 deficient rats exhibit changes in behavior, sensory function, and other nervous system abnormalities such as convulsive seizures and motor disturbances. Sensorimotor reactivity was evaluated quantitatively by measuring auditory and tactile startle responses in 12 week old female Long-Evans rats fed a diet devoid of added vitamin B-6 (DEF) or a control diet, either ad lib (AL-CON) or pair-fed to deficient rats (PF-CON). Deficiency was confirmed with a tryptophan-load test administered to a separate group of rats fed simultaneously according to the same protocol. At week 18, body weight and feed efficiency were different among groups (p<0.001), and were lowest in DEF. Amplitude of response to both acoustic and tactile stimuli was depressed in DEF compared to both control groups, which generally did not differ in response. This effect was seen most dramatically in responses to the acoustic stimulus (p=0.034), and especially to the first presentation (p=0.017). Latency to maximum response was not affected by diet. Possible mechanisms for this nervous system abnormality, not previously reported in vitamin B-6 deficiency, are discussed.
Finite Element Analysis of Load-Deflection and Creep Characteristics of Compressed Rubber Components for Vibration Control Devices

Elastomeric (rubber-like) materials are extensively used in various machine design applications, particularly for flexible elements of vibration/shock/noise control devices and of power transmission couplings. In order to have high performance characteristics, such elements should accommodate large static and dynamic loads and/or large deflections in a limited size. In many applications high damping, low creep and substantial nonlinearity of the load-deflection characteristic are required. These contradictory requirements are often impossible to satisfy just by selecting special rubber blends. It was demonstrated in [9] that for unbonded rubber flexible elements ofa cylindrical shape loaded in a radial direction, desirable nonlinear load-deflection characteristics can be naturally obtained, and creep rate can be significantly reduced as compared with conventional shapes of bonded rubber elements loaded in compression. This paper presents the second part of the study [9]. It applies the Finite Element Method to analyze large deformations of nonlinear components made of viscoelastic materials. Some convenient and efficient methods are proposed to determine material constants for the analytical study of static load-deflection characteristics and creep. These proposed methods result in good agreement between the numerical results and the experimental results in [9].
Responses of alfalfa pollen and callus to filtrates from two isolates of Fusarium oxysporum

For 25 Medicago sativa plants, measurements were made of in vitro pollen germination and growth and callus growth on mediums containing culture filtrate from two isolates of Fusarium oxysporum f. sp. medicaginis. In vivo resistance was determined by field inoculation with one isolate. There was no correlation between any in vitro measurement and in vivo resistance, and none of the in vitro measurements on control mediums were correlated. The only significant correlation for the same measurement between the two isolates was for pollen-tube length (r = 0.65). Percent of pollen germination was negatively correlated with callus growth for both isolates. Earlier work showed that callus growth in the presence of culture filtrate was linked to plant resistance, thus it appeared that percent pollen germination on culture filtrate had decreased for the more resistant plants. The haploid pollen may be used as a progeny test for identifying heterotic loci conferring resistance to Fusarium, but if the pollen of this plant species is used in direct selection by exposure to culture filtrate, the level of resistance to Fusarium may decrease.
P Values Maximized Over a Confidence Set for the Nuisance Parameter

Abstract For testing problems of the form H 0: v = v 0 with unknown nuisance parameter θ, various methods are used to deal with θ. The simplest approach is exemplified by the t test where the unknown variance is replaced by the sample variance and the t distribution accounts for estimation of the variance. In other problems, such as the 2 × 2 contingency table, one conditions on a sufficient statistic for 0 and proceeds as in Fisher's exact test. Because neither of these standard methods is appropriate for all situations, this article suggests a new method for handling the unknown θ. This new method is a simple modification of the formal definition of a p value that involves taking a maximum over the nuisance parameter space of a p value obtained for the case when θ is known. The suggested modification is to restrict the maximization to a confidence set for the nuisance parameter. After giving a brief justification, we give various examples to show how this new method gives improved results for 2 × 2 tabl...
Deprotonation of the 33-kDa, extrinsic, manganese-stabilizing subunit accompanies photooxidation of manganese in photosystem II.

Photosystem II catalyzes photosynthetic water oxidation. The oxidation of water to molecular oxygen requires four sequential oxidations; the sequentially oxidized forms of the catalytic site are called the S states. An extrinsic subunit, the manganese-stabilizing protein (MSP), promotes the efficient turnover of the S states. MSP can be removed and rebound to the reaction center; removal and reconstitution is associated with a decrease in and then a restoration of enzymatic activity. We have isotopically edited MSP by uniform 13C labeling of the Escherichia coli-expressed protein and have obtained the Fourier transform infrared spectrum associated with the S1 to S2transition in the presence either of reconstituted 12C or13C MSP. 13C labeling of MSP is shown to cause 30–60 cm−1 shifts in a subset of vibrational lines. The derived, isotope-edited vibrational spectrum is consistent with a deprotonation of glutamic/aspartic acid residues on MSP during the S1 to S2 transition; the base, which accepts this proton(s), is not located on MSP. This finding suggests that this subunit plays a role as a stabilizer of a charged transition state and, perhaps, as a general acid/base catalyst of oxygen evolution. These results provide a molecular explanation for known MSP effects on oxygen evolution.
Unimaginable Loss: Contingent Suicidal Ideation in Family Members of Oncology Patients

Background Family members of patients with cancer may reveal to the medical team that they are considering suicide after their loved one dies. No literature is available indicating how to assess risk and to intervene with these individuals. Objective The authors describe various alerting signs and seek to improve awareness and approaches to suicide prevention. Method The authors present five cases of potential contingent suicide. Results Family members struggling with anticipatory grief challenge the clinical team at several points of decision-making. Conclusion Close coordination among members of the patient's treatment team and psychiatric consultants is crucial for helping vulnerable family members move safely into adequately supported bereavement.
Structural basis of ferroelectricity in the bismuth titanate family

Abstract More than fifty ferroelectrics belong to the Bi4Ti3O12 family, and all consist of Bi2O2 layers interleaved with perovskite-like Mn−1RnO3n+1 layers. Crystal structures of three members of the family have been refined from x-ray and neutron diffraction data, elucidating the distortions responsible for ferroelectricity. Bi2WO6 (n = 1) is orthorhombic, space group B2cb; Bi3TiNbO9 (n = 2) orthorhombic, A21am; Bi4Ti3O12 (n = 3) monoclinic, Pc, but very nearly orthorhombic, B2cb. Similar distortions occur in all three structures, with large rotational motions accompanying the polarization along a . Below the transition, a strong Bi-O bond is formed to the apex oxygen of the perovskite layer, tilting the octahedra and producing antiparallel shifts along b . Symmetry differences in the even- and odd-layered compounds can be explained by the type of strains produced in the perovskite layer. The octahedral cations (W, Ti, Nb) are the major contributors to the spontaneous polarization, moving about 0.4A toward an octahedral edge.
Heat Capacity of Low Temperature Solid 3He

We have calculated the spin wave spectra and from these the specific heats of CNAF and UUDD solid 3 He at low temperatures. We compare with experiment and find good agreement even though we also find major deviations from simple T 3 behavior. The calculation included the six-spin exchange terms now recognized to be important for quantitative calculations. The inclusion of these terms was made more tractable by application of an algebraic technique from nuclear theory (Random Phase Approximation) for execution of the spin wave calculation, which nevertheless involved lengthy analysis