cssi/SciSciGPT-SciSciNet huggingface dataset:
Rad51 protein expression and survival in patients with glioblastoma multiforme.

Purpose Treatment of glioblastoma multiforme (GBM) continues to pose a significant therapeutic challenge, with most tumors recurring within the previously irradiated tumor bed. To improve outcomes, we must be able to identify and treat resistant cell populations. Rad51, an enzyme involved in homologous recombinational repair, leads to increased resistance of tumor cells to cytotoxic treatments such as radiotherapy. We hypothesized that Rad51 might contribute to GBM's apparent radioresistance and consequently influence survival. Methods and Materials A total of 68 patients with an initial diagnosis of GBM were retrospectively evaluated; for 10 of these patients, recurrent tumor specimens were used to construct a tissue microarray. Rad51 protein expression was then correlated with the actual and predicted survival using recursive partitioning analysis. Results Rad51 protein was elevated in 53% of the GBM specimens at surgery. The Rad51 levels correlated directly with survival, with a median survival of 15 months for patients with elevated Rad51 compared with 9 months for patients with low or absent levels of Rad51 ( p = .05). At disease recurrence, 70% of patients had additional increases in Rad51 protein. Increased Rad51 levels at disease recurrence similarly predicted for improved overall survival, with a mean survival of 16 months from the second craniotomy compared with only 4 months for patients with low Rad51 levels ( p = .13). Conclusion Elevated levels of the double-stranded DNA repair protein Rad51 predicted for an increase survival duration in patients with GBM, at both initial tumor presentation and disease recurrence.
Salvation, the Flesh, and God in Michel Tournier's Gaspard, Melchior et Balthazar

Michel Tournier's novel Gaspard, Melchior et Balthazar reveals his heterodox conception of Christianity. Its account of the birth of Christ implies that the Old Testament teaches one to reject the flesh but that the New Testament revalorizes the body, and this idea is supported by the changes in the magi when they see the infant Jesus, for each wise man learns to accept or rightly to value the flesh. An alternative to accepted Christianity is shown allegorically through Sangali's tale of the mythical king Barbedor, in which the Holy Spirit is more important than Jehovah or Christ. This idea is further developed in the story of a fourth wise man, Taor, who represents man unaffected by Old Testament doctrine and who is actually saved by the Holy Spirit rather than by Christ. Despite Tournier's claim to having written a Christian novel, the book puts the Holy Spirit rather than Christ at the center of the religion it presents.
The acquisition of future temporality by L2 French learners

This cross-sectional study in the acquisition of future temporality by English-speaking L2 French learners presents a descriptive account of the major contrastive features of the expression in futurity in English and French before considering learnability implications. A personal narrative and a cloze task were administered to L2 French learners (n = 34) at three proficiency levels and French native speaker controls (n = 14). Analyses revealed task and proficiency effects, but all learners used a variety of morphological forms to express futurity in their personal narratives, and appear to be acquiring temporal and modal values associated with the future.
Fact or Fiction? Gender Issues Related to Newspaper Reports of Intimate Partner Homicide

The present study compared newspaper articles reporting female-perpetrated intimate partner violence (IPV) homicides with those reporting male-perpetrated IPV homicides. Domestic violence was not mentioned in 72% of the articles. Female-perpetrated IPV homicide, although relatively rare, was not portrayed as more newsworthy nor did it receive more coverage when compared to male-perpetrated IPV homicide. When analyzing explanations for homicides given in newspaper reports, as well as descriptors used to describe the perpetrator, there was no support found for gender bias in favor of male perpetrators. Female victims were more likely to be portrayed as innocent when compared to males.
Neurocognitive function declines are reversible following migraine headache in college students

Computerized testing of neurocognitive function yields an accurate and reliable assessment [1]. There is little research on short-term effects of migraine headaches on neurocognitive function or their cognitive recovery patterns[2].
User Selection for SDMA Beamforming with Imperfect CSI in MIMO-OFDM Systems

Leveraging multi-user diversity by selecting users from a user pool has been a critical strategy for realizing a fraction of the MIMO broadcast channel capacity. This paper considers exploiting multi-user diversity in a unique and practical setting that includes - significant transmit correlation, a broadband channel using OFDM, and imperfect CSI at the transmitter derived from channel reciprocity techniques. These imply a higher correlation amongst user channels and an increase in the volume of CSI per user. Under these assumptions, algorithms are presented for selecting G out of Nu users for applying SDMA beamforming and also for switching off SDMA when the G selected user channels may not support simultaneous transmission. In a EUTRA-type simulation setting, the algorithms lead to gains on the order of 5-7 dB in coded FER with reasonable costs in terms of CSI, sum-rate and computational complexity.
D-arabitol metabolism in Candida albicans: construction and analysis of mutants lacking D-arabitol dehydrogenase.

Candida albicans produces large amounts of the acyclic pentitol D-arabitol in culture and in infected animals and humans, and most strains also grow on minimal D-arabitol medium. An earlier study showed that the major metabolic precursor of D-arabitol in C. albicans was D-ribulose-5-PO4 from the pentose pathway, that C. albicans contained an NAD-dependent D-arabitol dehydrogenase (ArDH), and that the ArDH structural gene (ARD) encoded a 31-kDa short-chain dehydrogenase that catalyzed the reaction D-arabitol + NAD D-ribulose + NADH. In the present study, we disrupted both ARD chromosomal alleles in C. albicans and analyzed the resulting mutants. The ard null mutation was verified by Southern hybridization, and the null mutant's inability to produce ArDH was verified by Western immunoblotting. The ard null mutant grew well on minimal glucose medium, but it was unable to grow on minimal D-arabitol or D-arabinose medium. Thus, ArDH catalyzes the first step in D-arabitol utilization and a necessary intermediate step in D-arabinose utilization. Unexpectedly, the ard null mutant synthesized D-arabitol from glucose. Moreover, 13C nuclear magnetic resonance studies showed that the ard null mutant and its wild-type parent synthesized D-arabitol via the same pathway. These results imply that C. albicans synthesizes and utilizes D-arabitol via separate metabolic pathways, which was not previously suspected for fungi.
Sources of variance in a female fertility signal: exaggerated estrous swellings in a natural population of baboons

Signals of fertility in female animals are of increasing interest to evolutionary biologists, a development that coincides with increasing interest in male mate choice and the potential for female traits to evolve under sexual selection. We characterized variation in size of an exaggerated female fertility signal in baboons and investigated the sources of that variance. The number of sexual cycles that a female had experienced after her most recent pregnancy (“cycles since resumption”) was the strongest predictor of swelling size. Furthermore, the relationship between cycles since resumption and swelling size was most evident during rainy periods and was not evident during times of drought. Finally, we found significant differences in swelling size between individual females; these differences endured across cycles (i.e., were not explained by variation within individuals) and persisted in spite of ecological effects. This study is the first to provide conclusive evidence of significant variation in swelling size between female primates (controlling for cycles since resumption) and to demonstrate that ecological constraints influence variation in this signal of fertility.
Consumers' captive service experiences: it's YOU and ME

Consumers in captive services often do not have the same experiences as consumers in typical service situations; this reality is largely ignored in existing service literature. To fill this void, this research makes a qualitative exploration of consumers' lived captive service experiences. It finds that consumers face several negative service processes. At the heart of these negative service experiences are the interactions of consumers with the service workers on whom they depend. Power has shifted to providers and this permits service organizations to deviate from accepted prudent service practices. Consumers experience service captivity and feel they have little or no recourse to the poor service treatment they receive. This does not, however, stop them from attempting to take back control of their consumption experience when and where possible. Consumers show marked resilience in the face of dehumanizing service interactions. Understanding developed in this research can be used to guide transformative...
Gettin’ Off the Streets: Support Programs for the Homeless

The homeless population has increased during this extended economic recession, but the concern for their plight remains inadequate given their level of destitution. Currently there are few vocational training programs designed to help the homeless get off and stay off the streets. What’s more, no federal grants directly fund adult job and skills training programs. As I have argued elsewhere, vocational training programs are essential for teaching marketable skills that will not only take people off the streets, but also keep them off of them.
A Review of “The Baltimore Elite Giants: Sport and Society in the Age of Negro League Baseball”

Bob Luke is the author of Dean of Umpires: The Biography of Bill McGowan, 1896–1954 (McFarland and Company, 2005) and Willie Wells: El Diablo of the Negro Leagues (University of Texas Press, 2007)....
Canonical correlations reveal co-variability between spike trains and local field potentials in area MT)

Patterns of neuronal correlations can provide important clues about the structure of the underlying network and how it processes information. Several recent studies have found that neural population activity across a region can be explained in large part by a shared, low-dimensional signal [1-5]. Population-wide correlation is likely to influence the local field potential (LFP) - an epiphenomenon that reflects low-frequency, concerted neural activity from anatomically connected circuits. Here, we show that LFP and spike trains recorded simultaneously from the middle temporal (MT) area of the awake macaque indeed share population-wide correlation. We apply canonical correlation analysis (CCA) to 16 channels of LFP and 16 spike sorted neurons (from 12 channels) acquired at 50 ms temporal resolution during inter-trial intervals (when the monkey was free to make eye movements), as well as during performance of a perceptual decision-making task (when the monkey maintained fixation and discriminated the direction of visual motion). CCA finds instantaneous linear projections of the LFP that maximize the correlation to corresponding projections of the population spike trains. Previous studies have suggested using population spike rate as a proxy for the local network state [3,5]. Applied to our dataset, we obtain a correlation coefficient of -12% between population spike rate and the mean LFP during inter-trial interval segments. In contrast, we obtain pairs of canonical variables with corresponding canonical correlations 29%, 26%, and 21%. We then applied the extracted projections to the task-relevant motion stimulus integration window. We find that the correlation of the projections is maintained for the 1st (31%) and 3rd (18%) components, but drops significantly for the 2nd component (7%)-- indicating a task-specific decoupling of LFP and spikes in a subspace uncovered by CCA. Upon further analysis, each CCA projection showed a distinct stimulus encoding pattern in spike rate and LFP. We hypothesize that CCA projections reveal functional, virtual units of information processing. The LFP is an important source of information when neural activity is correlated. It can indicate the strength of correlations, and the common input giving rise to such correlations. Additionally, the LFP provides increased statistical power to analyses, especially in areas where large-scale recording is anatomically difficult. CCA is a simple technique that can reveal low-dimensional structure in the data, uncovering components which maximize covariability between LFP and spike trains within MT.
The Use of Enteric Contrast Media for Diagnostic CT, MRI, and Ultrasound in Infants and Children: A Practical Approach.

OBJECTIVE. Enteric contrast media are commonly administered for diagnostic cross-sectional imaging studies in the pediatric population. The purpose of this manuscript is to review the use of enteric contrast media for CT, MRI, and ultrasound in infants, children, and adolescents and to share our experiences at a large tertiary care pediatric teaching hospital. CONCLUSION. The use of enteric contrast material for diagnostic imaging in infants and children continues to evolve with advances in imaging technology and available enteric contrast media. Many principles of enteric contrast use in pediatric imaging are similar to those in adult imaging, but important differences must be kept in mind when imaging the gastrointestinal tract in infants and children, and practical ways to optimize the imaging examination and the patient experience should be employed where possible.
Coherency Stresses in Mo/Ni Multilayer Films

Strain measurements were performed on multilayer films of Mo/Ni using x-ray diffraction with the scattering vector at varying degrees of inclination to the surface normal. In-plane variations in the lattice parameters confirm that there are coherency stresses between the Mo and Ni layers. Assuming the Nishiama-Wasserman orientation for the planes of Ni and Mo allowed the calculation of the complete stress state in both materials. The in-plane lattice parameter, the perpendicular lattice parameter and the unstrained lattice parameter have also been derived from the data. The substrate interaction stress which would be necessary to provide a force balance between the layers was calculated. This was found to be in good agreement with the global stress measured from wafer curvature. Preliminary results of modelling of the high angle superlattice lines to extract interfacial roughness in the growth direction are also presented.
The Computer, Personal Selling, and Sales Management:

SEVERAL years ago an article entitled "The Salesman Isn't De d, He's Different" was published.' It is now the sales manager's turn-he is not expendable, but he must become more sophisticated. He must learn to participate not only in the development, but also in the application, of new technology. The aggressive, knowledgeable sales manager must prepare now for what he soon will be required to do. One important aspect of that preparation must be a thorough knowledge of, and familiarity with, computer technology and the integration of the computer into his regular activities. The purpose of this article is to review published reports of the integration of the computer into sales management planning, organizing, and control activities. This is done: (1) to demonstrate the logical, but not necessarily inevitable, progression of a firm from simple computer-based data collection and manipulation into model building; and (2) to point out when and under what circumstances a particular system is useful to a sales manager. This latter objective is especially important since complex computer-based systems are frequently touted as the "answer" to the sales manager's problems. Often these computer-based systems are not necessary and a less complex system will suffice, or a simple system must be instituted and operated successfully before a more complex system can be installed. To facilitate the review, a categorization method is suggested that divides the literature on computer applications in sales management into two general areas: (1) sales reporting and analysis systems, and (2) planning-oriented systems. Sales Reporting and Analysis Systems
Eggs of Floodwater Mosquitoes. XIII. Chorionic Sculpturing

This paper is one of a series which seeks to aid researchers in identifying eggs and in clarifying the associations of species in higher taxa. Micrographs of whole eggs and segments of the chorion made with a scanning electron microscope are included.
Higher perioperative fluid administration is associated with increased rates of complications following head and neck microvascular reconstruction with fibular free flaps

Purpose The purpose of this study is to evaluate the impact of perioperative fluid administration on the rates of postoperative complications following head and neck reconstruction with fibular free flaps (FFF). Methods A retrospective cohort study of subjects undergoing head and neck reconstruction with FFF was completed. The primary predictor variable was the total volume of perioperative fluids administered on the day of surgery. The primary outcome variable was the presence of medical and surgical complications occurring within 30 days of surgery. Medical and surgical complications were stratified as major or minor based on severity level. Basic demographic information, comorbidity indices, and intraoperative parameters were abstracted as covariates. Univariable and multivariable models were developed to assess for associations between total fluid volume administered on the day of surgery and postoperative medical/surgical complications occurring within 30 days of surgery. Results In 154 subjects, the partial flap failure rate was 3% and there were no complete flap failures. Total fluid volume was significantly associated with the presence of postoperative medical/surgical complications (OR = 1.21; 95% CI: 1.02–1.44; p = 0.032). A cutpoint for total fluid volume predicting any severity level of postoperative complication was identified at 5,500 mL. A cutpoint for total fluid volume predicting major postoperative complications was identified at 7,000 mL. Conclusions The results of this study suggest that liberal fluid administration is associated with increased rates of medical/surgical complications following head and neck reconstruction with FFF. © 2016 Wiley Periodicals, Inc. Microsurgery, 2016.
I believe therefore I care: The relationship between religiosity, environmental attitudes, and green product purchase in Mexico

Purpose – The purpose of this paper is to investigate the impact of intrinsic religious orientation (IRO) on environmental attitudes (EA) and green product purchases (GPP) in Mexico. Design/methodology/approach – The study uses structural equation modeling to analyze the survey results of 242 consumers from Northern Mexico. Findings – The results of the study show a significant influence of EA on purchasing green products. In addition, the findings suggest that consumers with higher levels of IRO have a higher propensity to buy environmentally-friendly products, but do not show more favorable attitudes toward the environment than less-religious consumers. Research limitations/implications – The study relies on a convenience sample from Northern Mexico. Further, the study relies on self-reported measures of green product purchase (GPP) and future research should incorporate real purchases of green products in addition to self-reported measures. Practical implications – The findings of the study imply that ...
Improved power transfer to wearable systems through stretchable magnetic composites

The use of wireless power transfer is common in stretchable electronics since physical wiring can be easily destroyed as the system is stretched. This work presents the first demonstration of improved inductive power coupling to a stretchable system through the addition of a thin layer of ferroelastomeric material. A ferroelastomer, an elastomeric polymer loaded with magnetic particulates, has a permeability greater than one while retaining the ability to survive significant mechanical strains. A recently developed ferroelastomer composite based on sendust platelets within a soft silicone elastomer was incorporated into liquid metal stretchable inductors based on the liquid metal galinstan in fluidic channels. For a single-turn inductor, the maximum power transfer efficiency rises from 71 % with no backplane, to 81 % for a rigid ferrite backplane on the transmitter side alone, to 86 % with a ferroelastomer backplane on the receiver side as well. The coupling between a commercial wireless power transmitter coil with ferrite backplane to a five-turn liquid metal inductor was also investigated, finding an improvement in power transfer efficiency from 81 % with only a rigid backplane to 90 % with the addition of the ferroelastomer backplane. Both the single and multi-turn inductors were demonstrated surviving up to 50 % uniaxial applied strain.
SU-F-T-307: Peripheral Dose Comparison Between Static and Dynamic Jaw Tracking On a High Definition MLC System

Purpose: To investigate the effect of dynamic and static jaw tracking on patient peripheral doses. Materials and Methods: A patient plan with a large sacral metastasis (volume 800cm3, prescription 600cGyx5) was selected for this study. The plan was created using 2-field RapidArc with jaw tracking enabled (Eclipse, V11.0.31). These fields were then exported and edited in MATLAB with static jaw positions using the control point with the largest field size for each respective arc, but preserving the optimized leaf sequences for delivery. These fields were imported back into Eclipse for dose calculation and comparison and copied to a Rando phantom for delivery analysis. Points were chosen in the phantom at depth and on the phantom surface at locations outside the primary radiation field, at distances of 12cm, 20cm, and 30cm from the isocenter. Measurements were acquired with OSLDs placed at these positions in the phantom with both the dynamic and static jaw deliveries for comparison. Surface measurements included an additional 1cm bolus over the OSLDs to ensure electron equilibrium. Results: The static jaw deliveries resulted in cumulative jaw-defined field sizes of 17.3% and 17.4% greater area than the dynamic jaw deliveries for each arc. The static jaw plan resulted in very small differences in calculated dose in the treatment planning system ranging from 0–16cGy. The measured dose differences were larger than calculated, but the differences in absolute dose were small. The measured dose differences at depth (surface) between the two deliveries showed an increase for the static jaw delivery of 2.2%(11.4%), 15.6%(20.0%), and 12.7%(12.7%) for distances of 12cm, 20cm, and 30cm, respectively. Eclipse calculates a difference of 0–3.1% for all of these points. The largest absolute dose difference between all points was 6.2cGy. Conclusion: While we demonstrated larger than expected differences in peripheral dose, the absolute dose differences were small.
Toward the Development of Predictive Equations for Resting Metabolic Rate in Acutely Ill Spontaneously Breathing Patients

Background: There are many equations used for calculating energy needs of nutrition support patients but few developed specifically for the subset of spontaneously breathing acutely ill patients. The purpose of the current study was to validate existing equations and to start developing new equations for this cohort. Methods: Acutely ill patients not requiring mechanical ventilation had their resting metabolic rate measured using an indirect calorimeter. Metabolic rate was also calculated using the Mifflin–St Jeor equation, the Ireton-Jones equation for spontaneously breathing patients, and a modification of the Penn State equation in which the minute ventilation-dependent variable was removed. These calculated values were compared with measured expenditure and considered accurate if they fell within 10% of the measurement. Results: Fifty-five patients were measured successfully. The modified Penn State equation was accurate in 71% of patients compared with 44% for Ireton-Jones and 42% for Mifflin–St Jeor...
The 100-year journey of educational psychology: From interest, to disdain, to respect for practice.

From the very beginning of the APA, psychoeducational issues were important to our leaders, and those issues influenced the growth of academic and scientific psychology. In what follows, I describe the founding years of both general and educational psychology, noting the important individuals of those times and their influence on our discipline. The time period for those events was approximately 1890 to 1910, the same years that saw American psychology separate from its European roots and grow into a uniquely American discipline. But, we should remember that our field began long before that time.
Deconstructing Twentieth Century Medical Libraries: From Typewriters to Digital Libraries

ABSTRACTThe last 40 years has represented a time of change for the profession of library and information science, turning many of our constructs inside out. In 1977 the author attended library school, typewriter in hand, and with no thought that computers would one day alter the experience of “library” for everyone. This reflection provides an opportunity for the author, who was interviewed in this journal in the August 2010 issue (http://www.tandfonline.com/doi/abs/10.1080/15424065.2010.505510), to bring closure to a career in gratitude. Included are lessons learned throughout a career that spanned the beginning of the Internet, the arrival of Google, and a resurgence of new medical school libraries. One of the special challenges addressed is successfully juggling the career goals of a two-career marriage.
Logarithmic stress singularities resulting from various boundary conditions in angular corners of plates in extension

This note considers the in-plane loading of wedge-shaped plates comprised ofa single, homogeneous and isotropic, linear elastic material. Several instances of logarithmic stress singularities occurring at the vertices of such plates are provided in the literature. Here considerably more configurations with logarithmic singularities are identified.
Pharmacokinetics, tissue distribution, efficacy and toxicity studies of the antimelanoma immunocytokine scFvMEL/TNF

3726 The immunocytokine scFvMEL/TNF, a fusion protein composed of human cytokine tumor necrosis factor-alpha (TNF) and a single-chain Fv (scFvMEL), targets the melanoma gp240 antigen and exerts impressive cytotoxic effects in vitro. Pharmacokinetic studies with 125 I-scFvMEL/TNF showed triphasic clearance with calculated half-lives of 0.38, 3.9 and 17.6 hours for the alpha, beta and gamma phases respectively. The 45-kDa construct was found to self-aggregate into a 135-kDa trimer by virtue of the TNF component and this effect is likely to be responsible for the relatively long plasma half-life. Radiolabled scFvMEL/TNF was administered to nude mice bearing human melanoma xenografts, and mice were sacrificed at 24, 48 and 72 h after administration. We found that kidney and spleen contained the highest tissue: blood ratio of all normal organs. At 24 hr after administration, kidney, spleen and liver also contained the highest concentration of drug/gram tissue weight, although these concentrations declined over time. In contrast to normal organs, both the concentration of the label in tumor as well as the tissue: blood ratio of tumor tissue increased over time. Tumor was the highest site of accumulation by 72 hr after administration (% ID/g, 0.158; tumor-to-blood ratio, 7.6 ± 2.2), followed by kidney (% ID/g, 0.089; tissue-to-blood ratio, 5.1 ± 0.2), spleen (% ID/g, 0.049; tissue-to-blood ratio, 2.6 ± 0.8) and liver (% ID/g, 0.042; tissue-to-blood ratio, 1.6 ± 0.8). The maximal tolerated dose (MTD) of scFvMEL/TNF was 4 mg/kg with intravenous administration on a daily × 5 schedule. There were no changes in gross pathology, clinical chemistry or hematological parameters at doses up to 3 mg/kg. Therapeutic studies at a dose of 2.5 mg/kg with mice bearing established (∼ 50 mm 3 ) human melanoma A375 GFP xenograft tumors transfected with GFP demonstrated potent tumor suppression and complete tumor regression of all lesions (5/5 mice tumor-free on day 43). Mice bearing larger tumors (∼ 150 mm 3 ) also showed tumor regression (3/5 tumor free on day 44). There was no subsequent outgrowth of tumors from mice rendered tumor free. These data show that scFvMEL/TNF can target melanoma cells in vivo and can result in pronounced anti-melanoma effects after systemic administration. Toxicology studies indicate the relative safety of this agent at doses that are therapeutically effective and provide guidance to projected Phase I starting doses in patients at this schedule. Research conducted, in part, by the Clayton Foundation for Research.
Chapter 5.1 - Five-Membered Ring Systems: Thiophenes and Se/Te Derivatives

This chapter presents the synthesis of thiophenes, selenophenes and tellurophenes and their subsequent cyclization to corresponding bicyclo derivatives and/or substituted ring derivatives by appropriate substitution reaction. The application of these derivatives to material, photospectroscopic and medicinal sciences are briefly discussed.
"Product Complexity, network structure and product innovation performance"

Despite a consensus that a firm’s extended product development network plays a critical role in its innovation performance, empirical evidence linking network structure, product complexity, and pro...
Evolving Areas in Heart Transplantation

Abstract It has been 50 years since Dr. Christiaan Barnard performed the first human-to-human heart transplant in December 1967 in South Africa. Remarkable progress has been made since that time, including changes in surgical techniques, immunosuppression, donor and recipient selection, and post-transplant care. In this paper, we provide a perspective on the changing face of heart transplantation and highlight key evolving areas. Topics that are covered include advances in immunosuppression, screening for acute and chronic rejection, cardiac allograft vasculopathy, and ongoing advancements in cardiac replacement therapy, including xenotransplantation, stem-cell research, tissue engineering, and the total artificial heart.
High performance 36 GHz dielectric resonator oscillator

A 36 GHz dielectric resonator oscillator (DRO) exhibiting state of the art frequency stability and phase noise performance for application in high dynamic range radar systems and beacons will be reported in this paper.
Voltage-Controlled Spray Deposition of Multiwalled Carbon Nanotubes on Semiconducting and Insulating Substrates

A facile, cost-effective, voltage-controlled, “single-step” method for spray deposition of surfactant-assisted dispersed carbon nanotube (CNT) thin films on semiconducting and insulating substrates has been developed. The fabrication strategy enables direct deposition and adhesion of CNT films on target samples, eliminating the need for substrate surface functionalization with organosilane binder agents or metal layer coatings. Spray coating experiments on four types of sample [bare silicon (Si), microscopy-grade glass samples, silicon dioxide (SiO2), and polymethyl methacrylate (PMMA)] under optimized control parameters produced films with thickness ranging from 40 nm to 6 μm with substantial surface coverage and packing density. These unique deposition results on both semiconducting and insulator target samples suggest potential applications of this technique in CNT thin-film transistors with different gate dielectrics, bendable electronics, and novel CNT-based sensing devices, and bodes well for further investigation into thin-film coatings of various inorganic, organic, and hybrid nanomaterials on different types of substrate.
Optimized Rank Estimator in Big Data Social Networks

In this study, FAST Personalized PageRank is utilized to find the target node set. Using the mentioned target set, the algorithm gives an estimation of the closeness of any pair of nodes in the graph. Personalized Page Vector is used to find the most popular nodes, also known as hubs, in the network. The time taken by the estimation of Personalized PageRank is directly proportional to the network size. In this work, we proposed a node reduction method to prune the graph. To decrease the entropy and reduce the number of alternate paths to the target nodes, redundant popular nodes are identified and flagged. The flagged nodes are, then, given a lower priority in the computation. After pruning the graph, estimation results achieve an improved time complexity. The proposed method achieves a twice shorter computation time as compared to FAST PPR and Local Update.
On Parallel Numerical Software Libraries

We survey the design principles for writing numerical linear algebra software for high performance computers, especially parallel computers. After reviewing the architectural features of modern computers, we show how to exploit them in the design of a dense Gaussian elimination subroutine. We use software from the LAPACK and ScaLAPACK projects to illustrate.
The One-Dimensional Wave Equation and Its Solutions

At a sufficiently great distance from the sound source, the wave fronts become plane. The solutions of the wave equation then depend only on the coordinate x in the direction of propagation, \( \left( \frac{\partial \Phi }{\partial y}=\frac{\partial \Phi }{\partial z}=0 \right) \) and the wave equation reduces to $$ \frac{{{\partial }^{2}}\Phi }{\partial {{x}^{2}}}=\frac{1}{{{c}^{2}}}\frac{{{\partial }^{2}}\Phi }{\partial {{t}^{2}}} $$ (1) .
Panic with Agoraphobia

Carole had just turned 33 years old as she rounded off her 9th year of marriage to Ross. There had been an ongoing discussion between the two of them during the past year about whether or not to have a fourth child. This issue created some tension for Carole; she remained the undecided one. She put further discussion off with the excuse of waiting until after the Christmas holidays to make a decision. They had been in their new home for less than one year, and with all of the commotion, Carole had neglected to start her Christmas shopping—another burden on her mind. The combination of these events made for a very stressful period in her life, rendering her vulnerable to overload.
A new polymorph of eucryptite (LiAlSiO4), ε-eucryptite, and thermal expansion of α- and ε-eucryptite at high pressure

ABS I RAC I X-ray diffraction experiments have been carried out on β-eucryptite (LiAlSiO 4 ) at pressures up to 2.5 GPa and temperatures up to 1073 K in a large-volume apparatus. With room-temperature compression, we observed a phase transition to a new polymorph between 0.83 and 1.12 GPa. This transition is reversible in character. The new phase, referred to here as e-eucryptite, can be indexed according to an orthorhombic unit cell with a = 10.217(4) A, b = 8.487(4), A, c = 5.751(3) A, and V = 498.7(4) A 3 for XRD data at 2.2 GPa and 298 K. On heating at 2.2 GPa, e-eucryptite and β-eucryptite were metastable over the temperature interval 298-873 K; at higher temperatures they underwent an irreversible phase transition to α-eucryptite. Both hexagonal α-eucryptite and e-eucryptite show anisotropic thermal expansion. For α-eucryptite, we obtained α a = 6.71(′0.25) × 10 - 6 K - 1 , α c = 1.07(′0.05) × 10 - 5 K - 1 , and α v = 2.42(′0.1) x 10 - 5 K ' at 1.94(2) GPa over the temperature range 298-1073 K. For e-eucryptite at 2.32(8) GPa, we find larger thermal expansion in a smaller temperature range 298-773 K, with α a = 1.47(′0.15) × 10 - 5 K - 1 , α b = 6.65(′1.33) × 10 - 6 K - 1 , α c = 7.83(′0.88) × 10 6 K - 1 , and α v = 2.99(′0.15) × 10 - 5 K - 1 . In combination with a previous determination of thermal expansion at ambient pressure, the pressure effect on volume thermal expansion of α-eucryptite is determined to be -2.68 x 10 - 6 GPa - 1 K - 1 , and the temperature derivative of the bulk modulus is estimated to be -0.015 GPa/K.
Hawaiian style graffiti and the questions of sovereignty, law, property, and ecology:

Based on the ethnographic insight gained from the fieldwork conducted between 2006 and 2012 on the island of O‘ahu, this article attempts to capture the aesthetic and symbolic expressions of decolo...
Sonographic Findings Associated With Carpal Tunnel Syndrome

Purpose The purpose of this study was to identify associations between the clinical manifestations of carpal tunnel syndrome (CTS) and the sonographic measurements of the median nerve in the carpal tunnel. We hypothesized that sonographic changes in the median nerve from proximal to distal along the carpal tunnel would be associated with symptom severity scores. Methods We report on 38 patients with clinical signs and symptoms of CTS in a prospective investigation. Subjects underwent sonographic evaluation with measurement of median nerve cross-sectional area (CSA) at 3 locations: the level of the pronator quadratus, pisiform, and hamate. In addition, we measured dimensions of the carpal tunnel at the levels of the pisiform (inlet) and hamate (outlet). Finally, we recorded maximal thickness of the transverse carpal ligament (TCL). Patients underwent routine clinical evaluation and 31 patients had electrodiagnostic examination. Patients completed the Levine Katz Questionnaire (LKQ) to characterize severity of clinical symptoms. Each clinician was blinded to symptom severity scores. Pearson correlation coefficients were calculated to measure the relationship between LKQ score and sonographic measures. Results Median nerve CSA decreased over the course of the carpal tunnel from proximal to distal in 30 of 38 wrists. A greater absolute change in CSA of the median nerve over the course of the carpal tunnel between the pisiform and the hamate as well as between the pronator quadratus and the hamate correlated with increased severity of clinical symptoms. Increased thickening of the TCL also correlated with greater symptom severity scores. Conclusions Changes in CSA of the median nerve as well as thickening of the TCL correlate with CTS severity. Type of study/level of evidence Diagnostic II.
Different But Equal: The Philosophical Foundations of Forensic Archaeology

Archaeology and anthropology have a long-standing and often uneasy relationship. Anthropology, as the parent discipline, has provided the theoretical lens through which archaeological interpretation is viewed. However, archaeological methodology is unique and separate. Over the years, archaeology has been known at times to break away from anthropology with separate professional societies, separate university departments, and separate career tracks. Despite this, archaeology remains inextricably connected to anthropology. This chapter will discuss how and why archaeology and anthropology are distinct but complementary disciplines and how they have managed to coexist as such. Within the forensic community, forensic anthropology and archaeology in the United States have not been able yet to achieve this balance. The author will make the case for the philosophical foundations for forensic archaeology as separate from forensic anthropology specifically in the context of burial excavation.
The effects of antimicrobials on quality and sensory characteristics of blade tenderized beef strip loins

Abstract The beef industry utilizes blade tenderization (BT) to enhance tenderness; however, foodborne outbreaks have been associated with BT beef. Therefore, antimicrobials that reduce the risks associated with BT while maintaining quality are desired. The objective of this study was to assess the effects of pulse ultra-violet light (PUV), 5 mL/dL levulinic acid + 0.5 g/dL sodium dodecyl sulfate (LVA + SDS), and electrolyzed oxidizing water (EOW; 50 mg/L) on beef strip loins before BT for their impact on quality and sensory characteristics compared to 4.5 mL/dL lactic acid (LA) and no antimicrobial interventions (CON). Beef strip loins were independently subjected to treatments prior to BT. After BT, two steaks were removed from the anterior end for sensory and Warner-Bratzler shear force analysis, and six roasts were assigned to retail display for determination of shelf life characteristics. Aerobic plate count bacteria were lower (P ≤ 0.05) for LVA + SDS and LA compared to CON, EOW, and PUV. Treatment did not affect color, cooking, or sensory characteristics (P > 0.05). Lipid oxidation showed no difference among treatments (P > 0.05) until day 7 of display (P ≤ 0.05). These results suggest that LVA + SDS could be an alternative to LA without impacting quality and shelf life.
Probing peripheral neural pathways in electrically stimulation induced sensation

Electrical stimulation of peripheral nerves can elicit sensations in the residual and missing limbs of amputees. The goal of this study is to determine how electrical stimulation activates peripheral neural pathways by examining the relationship between elicited sensations and activation of residual muscles proximal to the amputation. In this study, high-density (16-contact) composite flat interface nerve electrodes were implanted on the sciatic and tibial nerves above the knee of a participant with a trans-tibial amputation. The sensations elicited by applying stimulating pulses to selected contacts within the electrodes were classified into three categories: tactile sensation in the residual limb, tactile sensation in the missing limb, and feeling of muscle contraction in the residual limb. Surface electromyograms (EMG) were recorded from below-knee muscles in the residual limb prior to and during stimulation. Initial results suggest direct peripheral afferent activation induces tactile sensation in the participant’s missing limb. No significant elevated EMG was observed in any of the below-knee muscles when the subject perceived tactile sensation in his missing limb. However, EMG activity was observed in at least one of the muscles when he perceived tactile sensation in his residual limb. Sensations of muscle contractions coincided with a much higher EMG activity in all residual muscles. Our findings suggest that elicited tactile sensations in the missing limb are largely due to direct activation of afferent fibers. However, muscle contraction sensation in the residual limb may result from afferent activation by muscle recruitment.
Analysis of Deep Neural Networks with Quasi-optimal polynomial approximation rates.

We show the existence of a deep neural network capable of approximating a wide class of high-dimensional approximations. The construction of the proposed neural network is based on a quasi-optimal polynomial approximation. We show that this network achieves an error rate that is sub-exponential in the number of polynomial functions, $M$, used in the polynomial approximation. The complexity of the network which achieves this sub-exponential rate is shown to be algebraic in $M$.
RNA Origami Nanostructures for Potent and Safe Anticancer Immunotherapy

Rapid developments in nucleic acid nanotechnology have enabled the rational design and construction of self-assembling DNA and RNA nanostructures that are highly programmable. We recently developed a replicable single-stranded RNA origami (RNA-OG) technology that allows a long RNA molecule to be programmed to self-assemble into nanostructures of various shapes. Here, we show that such RNA-OG is highly stable in serum/plasma, and we thus exploited its immunostimulatory potential. We demonstrated that the RNA-OG stimulates a potent innate response primarily through a Toll-like receptor 3 (TLR3) pathway. In a murine peritoneal metastatic colon cancer model, intraperitoneally injected RNA-OG induced significant tumor retardation or regression by activating NK- and CD8-dependent antitumor immunity and antagonizing the peritoneal immunosuppressive environment. Unlike polyinosinic/polycytidylic acid (PolyIC), a well-known double-stranded RNA analogue, the RNA-OG treatment did not cause a high level of type-I interferons in the blood nor apparent toxicity upon its systemic administration in the animals. This work establishes the function of RNA-OG as a potent line of TLR3 agonists that are safe and effective for cancer immunotherapy.
Choosing Hypotheses and Estimating Parameters from Experimental Data

First, we will discuss the important lemma of Fisher, which is the basis for our use of degrees of freedom when estimating parameters by making fits to experimental data. We will then discuss the maximum likelihood method and quote some general theorems concerning the efficiency and bias of estimates. Finally, we will examine sufficient statistics, and the testing and comparing of hypotheses using likelihood ratios.
Abstract PO-040: Therapeutic targeting of keratin 17 functional domains and nuclear export uncover therapeutic vulnerabilities of pancreatic cancer

The purpose of this study is to launch a novel biomarker-based targeted therapy that may result in improved precision and efficacy for the treatment of pancreatic ductal adenocarcinoma (PDAC). We discovered that Keratin 17 (K17), an oncofetal intermediate filament and nuclear oncoprotein expressed in 50% of PDAC cases, is a biomarker of the most aggressive and treatment-resistant form of PDAC. We set out to validate K17 as a druggable target and to identify K17-targeting mechanisms. In pre-clinical mouse models, animals bearing K17+ PDACs display the shortest survival, suggesting that K17 drives tumor aggression and should be explored as a potential therapeutic target. We used the following two approaches aimed to inhibit K17 nuclear shuttle functions, in order to identify therapeutic strategies: 1) Targeting K17 functional domains: By protein-sequence modeling analyses and site-directed mutagenesis, we identified functional domains in K17 (K17-FDs) that bind to, shift the subcellular localization of, and promote the degradation of nuclear tumor suppressors (e.g. p27). Using SILAC mass spectrometry of nuclear proteomes from isogenic human cells, we found that 80% of the nuclear proteome is altered by K17, that half of these proteins encode the domain targeted by the K17-FDs, and that a large proportion of these proteins are involved in gene expression. Animals harboring tumors with mutated K17-FDs lived two-times longer than control animals bearing K17+ PDACs, suggesting that the K17-FDs may be therapeutic targets. We are currently testing small molecule and peptide inhibitors to target the K17-FDs in vitro and in vivo, as a discovery approach to design small-molecule inhibitors of K17. 2) Targeting K17 nuclear export: K17 impacts the nuclear export of ~50% of the proteome and depends on exportin-1 (XPO1). We found that K17+ PDAC cells were more sensitive to Selective Inhibitor of Nuclear Export (SINE) therapy, leading to a 2-fold increase in cell death compared to control cells, suggesting that nuclear export by K17 in PDAC cells could be therapeutically targeted. SINE therapy is currently FDA-approved for treatment of other cancer types and repurposing for the treatment of K17-positive PDACs may result in enhanced therapeutic efficacy. In conclusion, these studies provide the basis for the development of novel biomarker-based therapeutic approaches using small-molecule inhibitors, to target K17 active sites or the pathways altered by this protein in PDAC. Citation Format: Cindy V. Leiton, Chun-Hao Pan, Ji Dong Bai, Lucia Roa-Pena, Sruthi Babu, Alex Penson, Nashaat Turkman, Richard Moffitt, Markus Seeliger, David Talmage, Kenneth R. Shroyer, Luisa F. Escobar-Hoyos. Therapeutic targeting of keratin 17 functional domains and nuclear export uncover therapeutic vulnerabilities of pancreatic cancer [abstract]. In: Proceedings of the AACR Virtual Special Conference on Pancreatic Cancer; 2020 Sep 29-30. Philadelphia (PA): AACR; Cancer Res 2020;80(22 Suppl):Abstract nr PO-040.