cssi/SciSciGPT-SciSciNet huggingface dataset:
Entwicklung von Finanzanalysesystemen

Die Entwicklung problemadaquater Finanzanalysesysteme erfordert eine prazise Spezifikation der Anforderungen. Anforderungen sind „Aussagen uber die Leistungen, die von einem System zu erbringen sind, sowie uber dessen qualitative und quantitative Eigenschaften.“1 Der Prozes der Anforderungsanalyse wird als Requirements Engineering bezeichnet und soll zu einer „vollstandigen, konsistenten und eindeutigen Spezifikation, in der beschrieben wird, was ein Softwareprodukt tun soll (aber nicht wie)“2, fuhren.
Practical Methods for Laboratory Photography

Although many investigators shy away from doing their own photography, there are many advantages for a student or investigator learning basic photographic methods in the laboratory. An excellent series of books by Ansel Adams (1980, 1981, 1983) are now available that give detailed descriptions of all aspects of basic photography. Among the most important reasons for learning photography for the laboratory are (1) cost effectiveness and efficiency, (2) immediate and complete data storage, and (3) accurate records of what is scientifically important.
The Capitalist World-System and U.S. Cold War Policies in the Core and the Periphery: A Comparative Analysis of Post-World War II American Nation-building in Germany and Korea

In response to the emerging cold war, why did the United States stress industrial expansion in Western Europe but focus on primary production alongside policing operations in the non-western world? Examining US postwar occupation in Germany and Korea from a world-systems perspective, this article argues that a given countrys standing in the capitalist economy generally shapes American foreign policy toward that particular country in the early cold war years. A paladin of system-wide prosperity and peace, the United States sought to restore the international division of labor after World War II. Reactions varied across the system, however, because of distinct socio-economic developments. The presence of capital-intensive export-dependent industry afforded western Germany flexible labor-management relations. Politics was overall stable there, and America dispensed with heavy-handed intervention. In southern Korea, labor-exploitive tenancy farming rendered interclass compromise virtually impossible. As intransigent peasants threatened the market economy, the United States used force to keep the ally in the system.
Separation of Variables

(1968). Separation of Variables. The American Mathematical Monthly: Vol. 75, No. 8, pp. 844-847.
The costs of crashing.

The application of the critical path method to a sales promotion effort is one approach for effective utilization of the talent and facilities budgeted for marketing support functions.
Uranium Adsorbent Fibers Prepared by Atom-Transfer Radical Polymerization from Chlorinated Polypropylene and Polyethylene Trunk Fibers

Seawater contains a large amount of uranium (∼4.5 billion tons) which can serve as a nearly limitless supply for an energy source. However, to make the recovery of uranium from seawater economically feasible, lower manufacturing and deployment costs are desirable, and good solid adsorbents must have high uranium uptake, reusability, and high selectivity toward uranium. In this study, atom-transfer radical polymerization (ATRP), without the high-cost radiation-induced graft polymerization, was used for grafting acrylonitrile and tert-butyl acrylate from a new class of trunk fibers, forming adsorbents in a readily deployable form. The new class of trunk fibers was prepared by the chlorination of polypropylene (PP) round fiber, hollow-gear PP fiber, and hollow-gear polyethylene fiber. During ATRP, degrees of grafting (d.g.) varied according to the structure of active chlorine sites on trunk fibers and ATRP conditions, and the d.g. as high as 2570% was obtained. Resulting adsorbent fibers were evaluated in U-...
Is the Specter of the Arab Spring Haunting Ethiopia

Although Ethiopia has never been a breeding ground for Islamism, the government has started to interfere in religious affairs in order to preempt radicalization. This strategy will most likely backfire, sowing the very seeds of political Islam that it seeks to keep at bay.
Virtual Prototype System Development and Research for Substation Equipment Inspection Robot

The use of computer virtual environment,the complex model of inspection robot research showing the real face of the designer and provide the actual situation is very close to the kinematic simulation tests.Using the software can display the real product development process for each environmental problems and propose timely solutions to shorten product development cycles and production costs.And for sector management and decision-making based on quantitative analysis.
Why Instructor Satisfaction Cannot be Ignored

eLearning is a teaching method that is popular in higher education, with institutions and students looking to take advantage of this increasingly more available educational option. An important factor of effective online education that is often overlooked in the research of eLearning involves the satisfaction of online instructors. This article looks at instructor satisfaction in terms of its importance (impact on instructors, students, and institutions), the variables that impact it, and methods to increase it.
An inference net compiler for the prospector rule-based consultation system

A compiler for the production system used in a rule-based consultation system is described. This compiler produces machine code which performs antecedent or data-driven inference In an efficient manner. Timing results and some limitations of the compiler are discussed.
Florisil Solid-Phase Extraction Cartridges for Cleanup of Organochlorine Pesticide Residues in Foods

Florisil solid-phase extraction cartridges were evaluated for cleanup of organochlorine pesticide residues in food extracts. Elution patterns and recoveries were determined for 24 organochlorine pesticides. A range of elution solvents was evaluated. A 2% ethyl ether-petroleum ether eluant optimized overall recoveries while minimizing interferences from coextractants.
Deterministic and Stochastic Aspects of Atmospheric Dynamics

We raise the question as to whether the atmosphere should be treated as deterministic or stochastic, for the purpose of investigating atmospheric dynamics most effectively. Because the atmospheric equations are nonlinear, all but special solutions must be sought numerically. The range of scales which numerical models can handle explicitly is limited, and the influence of smaller scales must be introduced through parameterization. The most realistic parameterization contain stochastic terms in addition to the deterministic ones. However, since realistic atmospheric models ordinarily possess aperiodic general solutions with or without their stochastic terms, they tend to yield similar results in either event. The choice between a deterministic and a stochastic formulation of the equations can therefore be dictated by convenience.
A Short Lifetime of Contributions

Except perhaps for Albert Einstein, there has perhaps been no scholar that has made such a profound contribution to scholarship in the natural and social sciences in such a brief time and at such a young age as had Frank Ramsey. Einstein’s Annus Mirabilis (Miracle Year) of 1905, resulted in a paper on the photoelectric effect, one on Brownian motion, another on special relativity, and still another that teased out his famous E = mc2 mass-energy equivalency. Einstein was 26 years old at the time, and he was to win the Nobel Prize in Physics in 1921 for his paper on the photoelectric effect.
Condensed matter: the continuous revolution

The discovery of relativity and quantum mechanics in the first decades of the 20th century overturned our view of the physical world. Indeed, many laypeople and historians of science, and even some physicists, were tempted to assume that everything since has merely been the working out of the consequences. There is, in this view, no possibility of a "continuous revolution" a la Chairman Mao.
Toxic Hemolysis in a Young Healthy Female.

Clostridium perfringes is a gram-positive, rod-shaped, anerobic, spore-forming pathogenic bacterium. C. perfringes is commonly known to cause tissue necrosis and gas gangrene. However, severe life-threatening complications like hemolysis due to clostridium sepsis are rarely encountered. We present a case of a 35-year-old female presenting with endometritis complicated with severe hemolysis in the setting of sepsis secondary to C. perfringes . Her hospital course was complicated with multi-organ involvement, requiring broad-spectrum intravenous antibiotics. Eventually, she made an uneventful recovery by early recognition of these rare complications and prompt institution of appropriate therapy. J Hematol. 2017;6(2-3):59-61 doi: https://doi.org/10.14740/jh328w
Results of lateral ankle ligament repair surgery in one hundred and nineteen patients: do surgical method and arthroscopy timing matter?

Ankle sprains are the most common athletic injury. One of five chronic lateral ankle instability patients will require surgery, making operative outcomes crucial. The purpose of this study is to determine if operative method influences failure and complication rates in chronic lateral ankle ligament repair surgery. We retrospectively reviewed 119 cases (118 patients) of lateral ankle ligament surgery between 2006 and 2016. Patient charts and operative reports were examined for demographics, use and timing of ankle arthroscopy, ligament fixation method, type of surgical incision, presence of calcaneofibular ligament repair, and operative technique. Impact of operative methods on failure (one-year minimum follow-up) and complication outcomes was explored using Chi-square test of independence (or Fisher’s exact test). Statistical significance was set at p less than .05. Mean age at surgery was 40 (range, 18-73) years. Mean follow-up was 51 (range, 12-260) weeks. Failure rate was 8.4% (10/89 cases) while complication rate was 17.6% (21/119). Failure rate did not differ significantly between any data subgroups (p > .05). Single stage arthroscopy was associated with a significantly lower complication rate (11%, 4/37) than double-stage arthroscopy (47%, 9/19) (p < .01) as was suture anchor ligament fixation (9%, 6/67) compared to direct suture ligament fixation (29%, 15/52) (p < .01). Failure rate was not impacted by any of the studied variables. Use of suture anchors and concurrent ankle arthroscopy may be favourable options to achieve fewer complications in chronic lateral ankle instability repair surgery.
The Cevian Problem.

Teachers should emphasize making connections to other areas of mathematics he Curriculum and Evaluation Standards for School Mathematics (NCTM 1989) challenges the teacher to shift away from memorization and set procedures. Instead, teachers should emphasize developing flex ible strategies of problem solving, finding multiple representations, and making connections to other areas of mathematics and to the real world. The cevian problem presented here illustrates how to implement this shift of emphasis. The five problem solving approaches include one strategy from a fifth-grade student that takes clever advantage of an alternative geometric representation. The cevian problem is also unusual because several other seemingly different problems unexpectedly have precisely the same answer. Thus, the cevian problem is especially useful in teaching and illustrating the techniques of problem solving. Fitting (1996) and Long and DeTemple (1996) both include descriptions of problem solving that follow the four-step process advocated by George P?lya. The short concluding section contains generalized versions of the problems. These problems can serve as topics for student investigations, perhaps in col laborative groups, for which students gather data and examples, make conjectures, construct proofs, and write reports that summarize their discoveries, methods, and reasoning. Students can thereby experience mathematics as problem solving, mathe matics as communication, mathematics as reason ing, and mathematics as making connections.
The Right to Be Helped. Deviance, Entitlement, and the Soviet Moral Order

In her comprehensive analysis of the Soviet construction of deviation, help and moral order, Maria Christina Galmarini-Kabala provides a historical lens for debates that cross disciplinary boundari...
Ethical dilemmas encountered by small animal veterinarians: characterisation, responses, consequences and beliefs regarding euthanasia

Small animal veterinarians' opinions were investigated regarding the frequency and nature of ethical dilemmas encountered, beliefs regarding euthanasia and balancing client and animal interests, prevalence and value of ethics training and proposals to mitigate the stressful effects of ethical dilemmas. The majority (52 per cent) of 484 respondents in the USA indicated via an online survey experiencing an ethical dilemma regarding the interests of clients and those of their patients at least weekly. Scenarios involving client financial concerns were commonly reported causes of ethical conflicts. While only 20 per cent of respondents indicated that other practitioners prioritise patient interests, 50 per cent of respondents characterised their own behaviour as prioritising patients. Most respondents (52 per cent) reported that ethical dilemmas are the leading cause, or are one of many equal causes, of work-related stress. Less experienced practitioners, general practitioners and associate veterinarians were more likely to encounter situations they defined as ethical dilemmas, and female respondents were more likely to find ethical dilemmas stressful. Most small animal veterinarians experience ethical dilemmas regularly, which contribute to moral stress. Results suggested that most small animal practitioners believe that greater awareness of moral stress and providing training in ethical theories and tools for coping with ethical dilemmas can ameliorate moral stress.
Addressing the Challenge of Coloniality in the Promises of Modernity and Cosmopolitanism to Higher Education: De-bordering, De-centering/De-peripherizing, and De-colonilizing

This chapter addresses the challenge of coloniality in the promises of modernity and cosmopolitanism to higher education in Africa by highlighting that Western higher education was founded under classical modernist and classical cosmopolitan perceptions of how the world ought to be ordered (or modernity) and how to nurture planetary conviviality (or cosmopolitanism). When we conceptualize higher education and scholarship within perspectives engendered by narratives of modernity and cosmopolitanism, even if at a critical modernist level, we rule out the problem of coloniality and fall short of being critically critical. I call for an engagement toward a de-bordering, de-centering/de-peripherizing, and de-colonilizing.
Johnson, Craig E. and Hackman, Michael Z. Leadership: A communication perspective. : 7th ed. Long Grove, IL: Waveland Press, Inc. (2018). 574 pages. ISBN: 978-1-4786-3502-4. $61.95

This text is designed to study leadership from a communication's perspective, as noted in the title to the publication. The target audience centers on those individuals seeking an introductory text...
Urodynamic Evaluation of Dysfunctional Bladder Neck Obstruction in Men

Dysfunctional bladder neck obstruction in young men has received increasing interest in recent years. The urodynamic characteristics of this disorder include elevated voiding pressure, normal reflex relaxation of the urethral rhabdosphincter, increased pressure gradient between the membranous urethra and the bladder, and inadequate radiographic bladder neck opening during detrusor activity. The functional changes occurring at the internal sphincter in 3 patients with dysfunctional bladder neck obstruction are described herein. It is demonstrated that the obstruction may result from either an active dyssynergic bladder neck contraction or failure of bladder neck relaxation. While the pathophysiology of dysfunctional bladder neck obstruction is uncertain possible mechanisms are discussed.
Galileo as Scientist and as Philosopher and the Emergence of Mathematical Physics in the 17th Century

Our topic is Galileo’s contribution to the concept of science. For many that is summed up in the following quote from The Assayer, written in 1623.
Don Quixote as Moral Narcissist: Implications for Mid-Career Male Ministers

This essay uses the figure of Don Quixote to explore the mid-career crisis experienced by many male ministers. It proposes that Don Quixote is less problematic than Don Juan for ethical reasons, but employs psychoanalytic interpretations to reveal the complexity of his self-structure, focusing especially on his moral narcissism, proneness to paranoia and melancholia, and his fictive personality. While evidence of his disordered mind, these diagnoses also testify to his nobility under trying circumstances. Heinz Kohut's concept of the transformation of narcissism is introduced and implications for the future destiny of Don Quixote are drawn. These implications have relevance to the issue of survival in ministry after the effects of the mid-career crisis have been absorbed.
Prodrugs to Improve the Oral Bioavailability of a Diacidic Nonpeptide Angiotensin II Antagonist

DMP 811 is a diacidic angiotensin II antagonist. It has relatively low oral bioavailability in rats. A prodrug approach to improving oral bioavailability was tested. Five esters were synthesized and their stability in rat plasma in vitro was determined. The hydrolysis rates of these five esters ranged from almost immediate to negligible. A simple n-propyl ester was hydrolyzed very slowly (< 10% in 24 hr) in rat plasma in vitro, and after oral dosing in rats plasma prodrug concentrations were much greater than DMP 811 concentrations. A pivaloyloxymethyl ester (1) was hydrolyzed relatively rapidly in rat plasma in vitro. Prodrug 1 was rapidly hydrolyzed by the intestine in vitro, and the intestinal permeation of DMP 811 was increased. DMP 811 oral bioavailability was 47% in rats dosed with 10 mg/kg 1, compared to 11% for rats dosed with 10 mg/kg DMP 811. However, DMP 811 bioavailability was only 27% after a 2 mg/kg dose of 1. In vitro plasma hydrolysis of 1 was highly species-dependent, with a half-life of 13 hr in human plasma but only 1 min in rat plasma. The prodrug approach has potential for improving the oral bioavailability of DMP 811, but selection of the optimal prodrug must be done in humans or in a species, such as dogs, with hydrolysis characteristics closer to humans.
Impact of Allograft Steatosis on Cardiovascular Outcomes

Cardiovascular events are among the most consequential long-term outcomes in liver transplant recipients. While underlying non-alcoholic fatty liver disease has been independently associated with unfavorable cardiovascular outcomes and increased mortality, it is unclear yet if the same holds true for allograft steatosis. We here review the available data on cardiovascular outcomes after liver transplant with specific focus on allograft steatosis. Two subtypes of hepatic allograft steatosis exist, recurrent and de novo, and both are common. Although the current data suggest an association between allograft steatosis and atherogenic lipid profile, they have yet to reveal a negative impact of allograft steatosis on cardiovascular outcomes or mortality. Targeting the metabolic risk factors in this patient population mainly via weight loss can improve outcomes. Use of angiotensin-converting enzyme might be protective against hepatic steatosis. More investigations into long-term outcomes of allograft steatosis with larger studies are needed.
BRCA1-Dependent Transcriptional Regulation: Implication in Tissue-Specific Tumor Suppression

Germ-line mutations in breast cancer susceptibility gene 1 (BRCA1) predominantly predispose women to breast and ovarian cancers. BRCA1 is best known for its functions in maintenance of genomic integrity including repairing DNA double-strand breaks through homologous recombination and suppressing DNA replication stress. However, whether these universally important BRCA1 functions in maintenance of genomic stability are sufficient to account for its tissue-specific tumor-suppressing function remains unclear. Accumulating evidence indicates that there are previously underappreciated roles of BRCA1 in transcriptional regulation and chromatin remodeling. In this review, we discuss the functional significance of interactions between BRCA1 and various transcription factors, its role in epigenetic regulation and chromatin dynamics, and BRCA1-dependent crosstalk between the machineries of transcription and genome integrity. Furthermore, we propose a model of how transcriptional regulation could contribute to tissue-dependent tumor-suppressing function of BRCA1.
Positive and Negative Factors That Influence Health Care Faculty Intent to Engage in Interprofessional Education (IPE)

Background: This study explored the positive and negative factors that influence interprofessional education (IPE) implementation in health care education programs across the United States. Methods: The study sample consisted of 439 (response rate 8.4%) health care faculties from seven health care professions (nursing, medicine, pharmacy, physical therapy, occupational therapy, physician assistant, and social work) who were asked what the positive and negative factors are that influence their decisions to engage in IPE. Results: Three positive categories and two negative categories concerning factors that influence health care faculty (HCF) intent to engage in IPE emerged. The three major categories of positive factors emerged as patient care, which was mentioned by 196 subjects or 54% of the sample, student learning, which was mentioned by 157 subjects or 43% of the sample, and health care teams, which was mentioned by 88 subjects or 24% of the sample. The two major categories of negative factors emerged as scheduling and coordination, which was mentioned by 230 subjects or 63% of the sample, and discipline culture which was mentioned by 103 subjects or 28% of the sample. Conclusion: This study contributes to the body of knowledge concerning the factors that influence effective IPE implementation. Discussion is provided regarding the positive and negative categories that emerged and how they influence effective IPE delivery.
Looking Ahead: October Term 2006

This paper, a chapter in the Cato Institute's forthcoming Supreme Court Review, offers one of the first looks at the impact of Justices Roberts and Alito on the Supreme Court. It also evaluates the extent to which Justice Kennedy has emerged - and has not emerged - as a swing justice following Justice O'Connor's departure. Reviewing the aggregate statistics from OT 05, it shows how, in some respects, Chief Justice Roberts has emerged as both the Court's uniter and its swing vote. After reviewing historical trends, the chapter then turns to the coming year's docket and evaluates the forthcoming cases in terms of the shifting voting dynamics. A critical question for the coming term will be whether Justice Kennedy hews to views and votes in dissenting opinions like Sternberg and Grutter or, whether in reliance on stare decisis or some other principle, he tacks more toward the center.
Affective and Normative Motives to Work Overtime in Asian Organizations: Four Cultural Orientations from Confucian Ethics

Asian workplaces are often characterized by cultures that require more overtime than other cultures. Although predictors for overtime work have been rigorously studied, it is still meaningful to investigate specific aspects of Eastern cultural values that stem from Confucian ethics and may influence overtime work among Asian employees. We suggest that four major Confucian orientations are positively associated with employees’ affective and normative motives, which in turn affect working overtime. This article extends management literature on the subjects of cultural ethics and workaholism. It also suggests how Eastern cultural values lead to working overtime. We hope that our research effort on Confucian cultural value and its associations with other managerial outcomes and theories is a small cornerstone that allows management researchers to explore interesting and meaningful ways to apply Confucian culture and orientations in the workplace.
Drug Delivery Strategies for the Treatment of Metabolic Diseases

Metabolic diseases occur when normal metabolic processes are disrupted in the human body, which can be congenital or acquired. The incidence of metabolic diseases worldwide has reached epidemic proportions. So far, various methods including systemic drug therapy and surgery are exploited to prevent and treat metabolic diseases. However, current pharmacotherapeutic options for treatment of these metabolic disorders remain limited and ineffective, especially reducing patient compliance to treatment. Therefore, it is desirable to exploit effective drug delivery approaches to effectively treat metabolic diseases and reduce side effects. This brief review summarizes novel delivery strategies including local, targeted, and oral drug delivery strategies, as well as intelligent stimulus-responsive drug delivery strategy, for the treatment of metabolic disorders including diabetes, obesity, and atherosclerosis.
Creating a 13-year National Longitudinal Cohort of veterans with chronic kidney disease

The development of large-scale chronic kidney disease (CKD) cohorts within the Veterans Affairs (VA) system has been limited by several factors, including the high proportion of missing race data etc. The goal of this study is to address the limitations of prior studies by creating a large cohort utilizing robust KDIGO recommendations for identifying and staging CKD. Multiple patient and administrative files from the Veterans Health Administration (VHA) National Patient Care were linked to create a national cohort of Veterans with chronic kidney disease (CKD) between January 2000 – December 2012; patients identified during this period were followed until 2015. CKD was defined for stages 1 through 5 if markers of kidney damage, specifically proteinuria, were present for at least 3 months. Estimated glomerular filtration rate (eGFR) values were calculated based on serum creatinine levels and the patient’s age, gender, and race using both the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas. About 50 million observations were collected that supported a CKD diagnosis during the study period; these observations corresponded to 3,051,001 unique veterans; 80.9% were non-Hispanic white (NHW), 13.4% were non-Hispanic black (NHB), 3.6% were Hispanic, and 2.0% were in other groups. The mean age 76.7, about 97% were male and 50.2% died prior to January 2016. Among those with stage 3, 12.3% progressed to stage 4, 21.6% of those with stage 4 progressed to stage 5. We found that eGFR values calculated from serum creatinine levels identified about 98% of all patients, while about 11.4% of patients could be identified through ICD-9 codes; only 6.4% could be identified through both sources. This 13-year national cohort provides an important resource for answering numerous research questions in the future such as racial/ethnic disparities questions, tracking health service utilization, medication adherence, cost and health outcomes in veterans with CKD.
O-031 Role of resistivity index analysis in the prediction of hemodynamically significant venous sinus stenosis in patients with idiopathic intracranial hypertension

Background The resistivity index (RI) in cerebral venous sinus stenosis (VSS) has not been studied in patients with idiopathic intracranial hypertension (IIH). Objective To evaluate the role of resistivity index (RI) measured by quantitative MRV (QMRV) as a non-invasive tool in the diagnosis of venous hypertension associated with VSS in idiopathic intracranial hypertension (IIH). Methods Retrospective evaluation of 13 consecutive IIH patients who underwent venous sinus stenting at our institution between 2013–2018 was reviewed. Patients’ demographics, clinical presentation, cerebral mean venous sinus pressure (MVP) and RI both pre and post-stenting were recorded. The baseline RI was also compared to a control group. Results Among 13 patients of IIH, 11 had unilateral VSS in dominant sinus, while 2 had bilateral VSS. RI was significantly higher in IIH patients compared to the control group in the superior sagittal (SSS) and transverse sinuses (TS) (0.21 vs 0.11, p = 0.01 and 0.22 vs 0.13, p = 0.03, respectively). The MVP (in mmHg) decreased significantly after venous sinus stenting in the SSS (41.9 to 22.5, p Conclusion RI calculated using QMRV can serve as a non-invasive tool to aid in the diagnosis of hemodynamically significant VSS. The study had a small sample size, and larger multicenter studies would be required to validate the results further. Disclosures M. Mohammaden: None. M. Rizwan Husain: None. D. Brunozzi: None. G. Atwal: None. F. Charbel: None. A. Alaraj: 1; C; NIH. 2; C; Cerenovus.
Recursive Rules with Aggregation: A Simple Unified Semantics.

Complex reasoning problems are most clearly and easily specified using logical rules, especially recursive rules with aggregation such as counts and sums for practical applications. Unfortunately, the meaning of such rules has been a significant challenge, leading to many different conflicting semantics. This paper describes a unified semantics for recursive rules with aggregation, extending the unified founded semantics and constraint semantics for recursive rules with negation. The key idea is to support simple expression of the different assumptions underlying different semantics, and orthogonally interpret aggregation operations straightforwardly using their simple usual meaning.
Technology-enabled activation of skin cancer screening for hematopoietic cell transplantation survivors and their primary care providers (TEACH).

Hematopoietic cell transplantation (HCT) is a curative option for a growing number of patients with hematologic diseases and malignancies. However, HCT-related factors, such as total body irradiation used for conditioning, graft-versus-host disease, and prolonged exposure to immunosuppressive therapy, result in very high risk for melanoma and non-melanoma skin cancer (NMSC). In fact, skin cancer is the most common subsequent neoplasm in HCT survivors, tending to develop at a time when survivors’ follow-up care has largely transitioned to the primary care setting. The goal of this study is to increase skin cancer screening rates among HCT survivors through patient-directed activation alone or in combination with physician-directed activation. The proposed intervention will identify facilitators of and barriers to risk-based screening in this population and help reduce the burden of cancer-related morbidity after HCT. 720 HCT survivors will be enrolled in this 12-month randomized controlled trial. This study uses a comparative effectiveness design comparing (1) patient activation and education (PAE, N = 360) including text messaging and print materials to encourage and motivate skin examinations; (2) PAE plus primary care physician activation (PAE + Phys, N = 360) adding print materials for the physician on the HCT survivors’ increased risk of skin cancer and importance of conducting a full-body skin exam. Patients on the PAE + Phys arm will be further randomized 1:1 to the teledermoscopy (PAE + Phys+TD) adding physician receipt of a portable dermatoscope to upload images of suspect lesions for review by the study dermatologist and an online course with descriptions of dermoscopic images for skin cancers. When completed, this study will provide much-needed information regarding strategies to improve skin cancer detection in other high-risk (e.g. radiation-exposed) cancer survivor populations, and to facilitate screening and management of other late effects (e.g. cardiovascular, endocrine) in HCT survivors. ClinicalTrials.gov, NCT04358276 . Registered 24 April 2020.
Analyzing acoustic and prosodic fluctuations in free speech to predict psychosis onset in high-risk youths

The diagnosis and treatment of psychiatric disorders depends on the analysis of behavior through language by a clinical specialist. This analysis is subjective in nature and could benefit from automated, objective acoustic and linguistic processing methods. This integrated approach would convey a richer representation of patient speech, particularly for expression of emotion. In this work, we explore the potential of acoustic and prosodic metrics to infer clinical variables and predict psychosis, a condition which produces measurable derailment and tangentiality in patient language. To that purpose, we analyzed the recordings of 32 young patients at high risk of developing clinical psychosis. The subjects were evaluated using the Structured Interview for Prodromal Syndromes/Scale of Prodromal Symptoms (SIPS/SOPS) criteria. To analyze the recordings, we examined the variation of different acoustic and prosodic metrics across time. This preliminary analysis shows that these features can infer negative symptom severity ratings (i.e., SIPS-Btotal), obtaining a Pearson correlation of 0.77 for all the subjects after cross-validated evaluation. In addition, these features can predict development of psychosis with high accuracy above 90%, outperforming classification using clinical variables only. This improved predictive power ultimately can help provide early treatment and improve quality of life for those at risk for developing psychosis.
Tenancy, finance, and access to commercial goods: Interpreting impoverished assemblages in Skagafjörður, Iceland, CE 1300–1900

Abstract Imported durable goods are relatively rare in non-elite Icelandic household assemblages, presenting a common difficulty for archaeologists studying impoverished assemblages. Test excavations of household middens across Skagafjorður, North Iceland allow for a comparison between elite (landowning seats of power) and non-elite (both owner-occupier and tenant) farms. Despite small sample sizes, the distribution of ceramic densities suggests: (1) an overall paucity in all time periods, (2) subtle inequalities between more and less productive farms, and (3) uneven but significant upticks in ceramic counts in the 19th century associated with a transition from tenant to owner-occupier households. The increase in ceramics is contrasted to the regional episcopal seat of Holar, which yielded an abundance of medieval and early modern imports but does not show an increase in ceramics in the 19th century, concurrent with the sale of its landholdings in CE 1802. We argue this trend is consistent with a shifting, unequally distributed, regional surplus in Skagafjorður tied to changes in property status, which suggests ways in which the financing of land ownership affects household archaeological assemblages.
Theism & Evolutionary Debunking Arguments Against Moral Realism

Evolutionary debunking arguments against morality come in a variety of forms that differ both in how they take evolution to be problematic for morality and in their specific target of morality i.e. objectivity, realism, justification for moral beliefs, etc. For the purpose of this paper, I will first articulate several recent debunking approaches and highlight what they take to be problematic features of evolutionary history for morality. In doing so I will be forced to abstract from some of the specific arguments offered, although I will provide replies to particular aspects of the arguments offered by Michael Ruse, Sharon Street and Richard Joyce. Then, I will show that theists have independent reasons for rejecting certain, core assumptions of these debunking approaches, thus deflating the major thrust of debunking worries for morality. While there may be good responses available to the non-theist realist with respect to several of the worries raised below, this paper will simply show why the theist need not be troubled by contemporary debunking approaches against morality.
Computer-Aided Rhinoplasty Using a Novel “navigated” Nasal Osteotomy Technique: A Pilot Study:

Objective:To describe the surgical technique of navigation-guided nasal osteotomies and assess feasibility of this technique for treating complex nasal bone deformities in reconstructive rhinoplast...
Experiences in System Reliability Optimization Including Damage Constraints

To design an optimal structure, both the ultimate or reserve requirements of the intact system and the residual system reliability requirements of the damaged system are simultaneously used as constraints. This approach requires the use of hazard accident scenarios outlining both the damage and the probability of the initiating event. In this study, the system reliability constraints in the optimization incorporate both the initiating probability and the residual system reliability. In the paper, a constrained optimization method is used to minimize weight or cost with a range of system reliability constraints for the intact and damaged systems. The system reliability analysis leads to an array of modal failure probabilities as well as a combination of modes into an overall system failure estimate.
Functional characterization of the INO2 gene of Saccharomyces cerevisiae. A positive regulator of phospholipid biosynthesis.

The INO2 locus encodes a novel product showing structural similarity to the basic helix-loop-helix (b-HLH) family of regulatory proteins (Nikoloff, D.M., McGraw, P., and Henry, S.A. (1992) Nucleic Acids Res. 20, 3253). The ino2 mutants exhibit pleiotropic defects in phospholipid metabolism including inability to derepress the biosynthetic enzyme inositol-1-phosphate synthase. Localization of mutations in ino2 strains has demonstrated that the b-HLH domain is required for biological activity and is sensitive to perturbation, thereby establishing a correlation between the structure and function of Ino2p. Defects in the b-HLH domain of Ino2p resulted in reduced DNA binding activity. In addition, the absence of a specific DNA-protein complex correlated with a reduction or loss of INO1 transcription. Studies using Ino2p-specific antibody revealed that Ino2p participates in the formation of specific DNA-protein complexes. Ino2p-dependent binding activity overlapped with a region of the INO1 promoter that contains two potential HLH consensus binding sites. Furthermore, Ino2p showed single base pair discrimination in a putative binding site, establishing a relationship between Ino2p and its target binding site.
Parent Involvement, Influence, and Satisfaction in Magnet Schools: Do Reasons for Choice Matter?.

This paper explores the relationships between parents' reasons for choosing a magnet school and their levels of satisfaction, involvement, and influence with the school. Data are reported from over a thousand magnet school parents in two urban districts. The results suggest three general findings: (1) As reported in previous research, magnet school parents choose schools for a wide array of reasons and are highly satisfied with their chosen school; (2) parents' reasons for choice are important predictors of their levels of satisfaction, influence, and involvement with the school; and (3) parents who choose for values reasons, as compared to other reasons, are more likely to be involved in and satisfied with their school of choice and report that parents have influence over school decisions.
Evolution of the role of Cdc48 and its interactions with the 20S peptidase (478.1)

Proteasomes are ubiquitous ATP-dependent proteases that function in eukarya, archaea, and actinobacteria. These proteolytic machines employ a barrel-shaped 20S core peptidase and a hexameric AAA+ u...
Slinky: static linking reloaded

Static linking has many advantages over dynamic linking. It is simple to understand, implement, and use. It ensures that an executable is self-contained and does not depend on a particular set of libraries during execution. As a consequence, the user executes exactly the same executable image as was tested by the developer, diminishing the risk that the user's environment will affect correct behavior. The major disadvantages of static linking are increases in the memory required to run an executable, network bandwidth to transfer it, and disk space to store it. In this paper we describe the SLINKY system that uses digest-based sharing to combine the simplicity of static linking with the space savings of dynamic linking: although SLINKY executables are completely self-contained, minimal performance and disk-space penalties are incurred if two executables use the same library. We have developed a SLINKY prototype that consists of tools for adding digests to executables, a slight modification of the Linux kernel to use those digests to share code pages, and tools for transferring files between machines based on digests of their contents. Results show that our prototype has no measurable performance decrease relative to dynamic linking, a comparable memory footprint, a 20% storage space increase, and a 34% increase in the network bandwidth required to transfer the packages. We believe that SLINKY obviates many of the justifications for dynamic linking, making static linking a superior technology for software organization and distribution.
The baseleaf preserving mapping class group of the universal hyperbolic solenoid

Given a closed surface X, the covering solenoid X∞ is by definition the inverse limit of all finite covering surfaces over X. If the genus of X is greater than one, then there is only one homeomorphism type of covering solenoid; it is called the universal hyperbolic solenoid. In this paper we describe the topology of Γ(X∞), the mapping class group of the universal hyperbolic solenoid. Central to this description is the notion of a virtual automorphism group. The main result is that there is a natural isomorphism of the baseleaf preserving mapping class group of X∞ onto the virtual automorphism group of π 1 (X, *). This may be regarded as a genus independent generalization of the theorem of Dehn, Nielsen, Baer, and Epstein that the pointed mapping class group r(X, *) is isomorphic to the automorphism group of π 1 (X, *).
Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons

Cellular interactions in a variety of vertebrate non-neural tissues are thought to be mediated by cell surface carbohydrate structures. The detection of cell-specific surface carbohydrates and carbohydrate- binding proteins within the embryonic nervous system has raised the possibility that carbohydrate recognition may also contribute to the interactions of developing neurons. Soluble lactose-binding lectins constitute one class of carbohydrate-binding proteins expressed in the vertebrate nervous system. We describe here the isolation of cDNAs from rat brain libraries encoding one of these lectins, RL-14.5, and demonstrate that this protein is not only homologous to other soluble lectins, but also identical in primary sequence to a lectin present in at least one non-neural tissue. RNA blot analysis and in situ hybridization reveal a restricted pattern of expression of RL-14.5 mRNA within the rat nervous system. High levels of RL-14.5 mRNA are present in primary sensory neurons and motoneurons in the spinal cord and brain stem. Moreover, expression of RL-14.5 mRNA in sensory and motoneurons is detectable soon after neuronal differentiation. These findings, together with previous studies demonstrating the selective expression of oligosaccharide ligands for RL-14.5 on the same neurons, are consistent with the idea that carbohydrate-mediated interactions contribute to the development of this subset of mammalian neurons.
Ultrastructural Localization of Hydrogen Peroxide Production in Ligninolytic Phanerochaete chrysosporium Cells.

Previous studies have shown that the hydroxyl radical derived from hydrogen peroxide (H2O2) is involved in lignin degradation by Phanerochaete chrysosporium. In the present study, the ultrastructural sites of H2O2 production in ligninolytic cells of P. chrysosporium were demonstrated by cytochemically staining cells with 3,3'-diaminobenzidine (DAB). Hydrogen peroxide production, as evidenced by the presence of oxidized DAB deposits, appeared to be localized in the periplasmic space of cells from ligninolytic cultures grown for 14 days in nitrogen-limited medium. When identical cells were treated with DAB in the presence of aminotriazole, periplasmic deposits of oxidized DAB were not observed, suggesting that the deposits resulted from H2O2-dependent peroxidatic oxidation of DAB by catalase. Cells from cultures grown for 3 or 6 days in nitrogen-limited medium or for 14 days in nitrogen- sufficient medium had little ligninolytic activity and low specific activity for H202 production and did not contain periplasmic oxidized DAB deposits. The results suggest that in cultures grown in nitrogen- limited medium, there is a positive correlation between the occurrence of oxidized DAB deposits, the specific activity for H2O2 production in cell extracts, and ligninolytic activity. (Refs. 25).
Biological Phosphorus Cycling in Dryland Regions

The relatively few studies done on phosphorus (P) cycling in arid and semiarid lands (drylands) show many factors that distinguish P cycling in drylands from that in more mesic regions. In drylands, most biologically relevant P inputs and losses are from the deposition and loss of dust. Horizontal and vertical redistribution of P is an important process. P is concentrated at the soil surface and thus vulnerable to loss via erosion. High pH and CaCO3 limit P bioavailability, and low rainfall limits microbe and plant ability to free abiotically bound P via exudates, thus making it available for uptake. Many invasive plants are able to access recalcitrant P more effectively than are native plants. As P availability depends on soil moisture and temperature, climate change is expected to have large impacts on P cycling.
Noninvasive estimation of systolic and diastolic arterial compliance

An analog circuit model has been developed to compute systolic and diastolic compliances of the arterial system in the human using a single noninvasive displacement transducer located at the superficial carotid artery. The LICO model (Local Impedance, Compliance and Output model) is driven by a step input of pressure equal in amplitude to the pulse pressure. The timing of the resulting flow is determined from the carotid pulse contour. A study of records from one hundred and two cardiac surgery patients shows that the LICO model compliance correlates well with a common measure of compliance; the ratio of the stroke volume to the pulse pressure, /spl Delta/V//spl Delta/P (systolic compliance r=0.821, p >