cssi/SciSciGPT-SciSciNet huggingface dataset:
What was John Dewey's Fascination with Nature Study?

In Democracy and Education, John Dewey revealed his fascination with and admiration for the late nineteenth and early twentieth century movement to incorporate the study of nature into the school curriculum. His extended discussion treats nature as both subject matter for scientific investigation and a vital foreground for consummatory or aesthetic experience. Looking to the history of the nature study movement, though, one finds several of its popular defenders, such as the naturalist John Burroughs and the essayist Dallas Lore Sharp, criticizing the specialized approach to inquiry that Dewey and other proponents of the technosciences favored. These nature study advocates sought a return to a more romantic, holistic and affective appreciation of nature, not the cold and impersonal perspective of the scientific inquirer. In this paper, I seek to (i) reconcile Dewey's reasons for defending nature study with those of the movement's founders and early advocates, (ii) rely on the writings of Aldo Leopold, who was exposed to nature study at an early age, as a resource for achieving this reconciliation, and (iii) draw out the implications of this reconciliation for a renascent nature study movement, one that returns the observation and appreciation of the natural environment to the grade school curriculum.
Reverse-total shoulder arthroplasty cost-effectiveness: A quality-adjusted life years comparison with total hip arthroplasty.

Reverse-total shoulder arthroplasty cost-effectiveness: A quality-adjusted life years comparison with total hip arthroplasty
Management of vertical ocular deviations secondary to restrictive conditions.

BACKGROUND AND PURPOSE Management of vertical strabismus secondary to restrictive conditions can be challenging for both the patient and practitioner. The purpose of this paper is to identify both common and uncommon causes of vertical restrictive strabismus, to discuss the evaluation of these conditions, and to briefly review the etiology and recommendations for surgical management. METHOD Current literature was reviewed as well as the surgical techniques that have been found to be most useful from experience over the past twenty years of practice. CONCLUSION Surgical realignment and elimination of diplopia is both challenging and problematic. Surgery should be designed to relieve restriction, with attention to identifying and managing incomitance. Furthermore, it is important to establish realistic goals with patients.
Recent Advances in Acarology

For the first time in the western hemisphere, 168 acarologists from the diverse disciplines of taxonomy, physiology, biochemistry, genetics, disease transmission, behavior and economic control met together to share their advances in research and to discuss their mutual interest-acarology. Many in attendance agreed that this historic meetil? has speeded the development of the rapidly expanding discipline of acarology and another meeting was proposed for Denver, Colorado in 1963. Acarologists from Germany, France. Belgian Congo, South Africa Canada, New Zealand and the Canal Zone were present: Notable among these international acarologists was Marc Andre, editor of Acarologia.
Structure of Nanophase Gold Particles on Iron Oxide Supports

Ultra-fine gold particles supported on iron oxide have been synthesized by coprecipitation and subsequently heat treated in air at temperatures ranging from 200°C to 700°C. Structure analyses have revealed variations in the degree of crystallinity of the iron oxide support as well as gold particle size and size distribution with heat treatment temperature. In addition, lattice parameters of gold particles were observed to deviate up to ten percent from the bulk value. We discuss these observations in light of a total minimization of the energy of the system (support plus particles).
A new springsnail (Hydrobiidae: Pyrgulopsis ) from the Lower Colorado River basin, northwestern Arizona

We describe a new springsnail species, Pyrgulopsis hualapaiensis, from the Lower Colorado River basin (northwestern Arizona) that has an ovate- to narrow-conic shell and narrow penis ornamented with a small gland on the distal edge of the lobe. This new species differs from closely similar congeners from the Lower Colorado River basin in several details of female reproductive anatomy and in its mtCOI haplotype (3.0%–5.0% mean sequence divergence). Bayesian, maximum parsimony, and distance-based phylogenetic analyses of COI data congruently resolved P. hualapaiensis as sister to a divergent lineage of Pyrgulopsis thompsoni in the middle Gila River watershed (southeastern Arizona), although this relationship was not well supported. Pyrgulopsis hualapaiensis is endemic to a spring complex in the Hualapai Indian Reservation that is a culturally sensitive site for the tribe. The small population of these snails appears to be robust despite recent habitat modifications (trenching of outflow and construction of a spring box) and disturbance from road traffic. Future conservation measures could include monitoring of the population and augmentation of the gravel habitat used by these snails.
Corrigendum to: “Clifford Theory of a Finite Group that Contains a Defect 0 p-Block of a Normal Subgroup”

At some point, after publication, the author realized that the proof of [3, Theorem 5.2] is incorrect. This proof incorrectly adapts the proof of [1, Theorem 4.8] since [3, (5.5)] is incorrect. Using the same proof outline, we correct the proof of [3, Theorem 5.2].
The application of PLC for control sy stems in wastewater treatment plant

Introduces a distributed I /Ocontro l system of a wastewater treatment pl ant.The core of this systemis PLC.It is proved that the control system has reasonable structure,perfe ct functions and high reliability.T his system is worth applied to all wastew ater treatment plants of our country.
Proton Pump Inhibitors: Risk for Myopathy?

Objective: The purpose of this article is to describe the relationship between proton pump inhibitors (PPIs) and symptoms of myopathy based on case reports. Data Sources: A literature search was conducted in PubMed (1946 to June 2016) using MeSH terms proton pump inhibitors, omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole, pantoprazole, and muscular diseases. Additionally, a search was conducted in ToxNet and EMBASE using similar search criteria. Study Selection and Data Abstraction: The resulting articles were scanned to assess relevance to the review. Bibliographies of all relevant articles were evaluated for additional sources; 26 articles resulted from the search of PubMed, ToxNet, and EMBASE; articles that involved medications typically considered to have myalgia-like side effects (eg, statins), or included patients who presented with a confounding disease state (eg, Guillain-Barre) were excluded. Data Synthesis: In total, 11 case reports as well as a review of an adverse event r...
Ultrafast dynamics of colloidal semiconductor nanocrystals relevant to solar fuels production

Artificial conversion of sunlight to chemical fuels has attracted attention for several decades as a potential source of clean, renewable energy. We recently found that CdSe quantum dots (QDs) and simple aqueous Ni2+ salts in the presence of a sacrificial electron donor form a highly efficient, active, and robust system for photochemical reduction of protons to molecular hydrogen. Ultrafast transient absorption spectroscopy studies of electron transfer (ET) processes from the QDs to the Ni catalysts reveal extremely fast ET, and provide a fundamental explanation for the exceptional photocatalytic H2 activity. Additionally, by studying H2 production of the Ni catalyst with CdSe/CdS nanoparticles of various structures, it was determined that surface charge density plays an important role in charge transfer and ultimately H2 production activity.
Interpreting the Collision Cross Sections of Native-like Protein Ions: Insights from Cation-to-Anion Proton-Transfer Reactions

The effects of charge state on structures of native-like cations of serum albumin, streptavidin, avidin, and alcohol dehydrogenase were probed using cation-to-anion proton-transfer reactions (CAPTR), ion mobility, mass spectrometry, and complementary energy-dependent experiments. The CAPTR products all have collision cross-section (Ω) values that are within 5.5% of the original precursor cations. The first CAPTR event for each precursor yields products that have smaller Ω values and frequently exhibit the greatest magnitude of change in Ω resulting from a single CAPTR event. To investigate how the structures of the precursors affect the structures of the products, ions were activated as a function of energy prior to CAPTR. In each case, the Ω values of the activated precursors increase with increasing energy, but the Ω values of the CAPTR products are smaller than the activated precursors. To investigate the stabilities of the CAPTR products, the products were activated immediately prior to ion mobility. ...
LATE MORBIDITY IN INFANTS WITH CONGENITAL DIAPHRAGMATIC HERNIA: A FOLLOW-UP STUDY

Aim New treatments have improved survival rate in CDH infants in comparison with past decades. However this better survival has raised concern about the long term morbidity, particularly in the first few years of life. Aim of our study is to evaluate the role of a multidisciplinary follow up for high risk CDH survivors. Methods All high risk CDH survivors consecutively treated between 2004 and 2007 were included into our follow-up clinics. Prevalence of late morbidity was prospectively evaluated at 6 months, 1 and 2 years. Clinical examinations included auxological, gastro-intestinal, pulmonary, orthopedic and audiological evaluation. Comparison of prevalences at various ages was performed with the McNemar test. Results 44 patients were enrolled into our follow-up program. Main results are summarized in the table. Conclusion CDH survivors may present late morbidity. Our results highlight the importance of a multidisciplinary long term follow up to limit sequelae. Particularly, oral aversion and orthopedic disorders significantly increase with the age in our series, recommending a long term evaluation. More studies are needed to better understand the role of new treatments in the development of late morbidity in CDH survivors.
Finding multiscale connectivity in our geospace observational system: Network analysis of total electron content

We present the first complex network theory based analysis of high-latitude total electron content (TEC) data, including dependencies on interplanetary magnetic field (IMF) clock angle and hemisphere. We examine several network measures to quantify the spatio-temporal correlation patterns in the TEC data for winter and summer months in 2016. We find that significant structure exists in the correlation patterns, distinguishing the dayside and nightside ionosphere, and specific features in the high latitudes such as the polar cap and auroral oval, including the cusp and ionospheric footpoints of magnetospheric boundary layers. These features vary with the IMF, exhibiting a strong dependence on the north-south direction and generally larger variations during the winter months in both hemispheres. Our exploratory results suggest that network analysis of TEC data can be used to study characteristic ionospheric spatial scales at high-latitudes, thereby extending the utility of these data. We explore meso- and large-scales (>10s km and >100s km, respectively) as a function of winter/summer season, hemisphere, and IMF direction and conclude that the relative importance of different ionospheric scales is not a constant relationship. Together with an identification of important areas of future work, our findings provide a foundation for the application of network analysis techniques to ionospheric TEC. Our results suggest that network analysis can reveal new physical connections in the ionospheric system.
PRiMeUM: A Model for Predicting Risk of Metastasis in Uveal Melanoma.

Purpose To create an interactive web-based tool for the Prediction of Risk of Metastasis in Uveal Melanoma (PRiMeUM) that can provide a personalized risk estimate of developing metastases within 48 months of primary uveal melanoma (UM) treatment. The model utilizes routinely collected clinical and tumor characteristics on 1227 UM, with the option of including chromosome information when available. Methods Using a cohort of 1227 UM cases, Cox proportional hazard modeling was used to assess significant predictors of metastasis including clinical and chromosomal characteristics. A multivariate model to predict risk of metastasis was evaluated using machine learning methods including logistic regression, decision trees, survival random forest, and survival-based regression models. Based on cross-validation results, a logistic regression classifier was developed to compute an individualized risk of metastasis based on clinical and chromosomal information. Results The PRiMeUM model provides prognostic information for personalized risk of metastasis in UM. The accuracy of the risk prediction ranged between 80% (using chromosomal features only), 83% using clinical features only (age, sex, tumor location, and size), and 85% (clinical and chromosomal information). Kaplan-Meier analysis showed these risk scores to be highly predictive of metastasis (P < 0.0001). Conclusions PRiMeUM provides a tool for predicting an individual's personal risk of metastasis based on their individual and tumor characteristics. It will aid physicians with decisions concerning frequency of systemic surveillance and can be used as a criterion for entering clinical trials for adjuvant therapies.
Die Wende Als Streich Der Geschichte: Zu Volker Brauns Die Vier Werkzeugmacher

Volker Braun's Die vier Werkzeugmacher is a remarkable narrative about a collective of East German toolmakers, whose privileged life finds an abrupt end after the collapse of the GDR in 1989. The story is adapted from a 15th century Italian novella by Antonio Manetti about a fat wood carver, who became the victim of a cruel prank by his fellow craftsmen and artists of Florence. This article investigates the intertextuality of Braun's adaptation, the interrelation of the themes of loss of individual and collective identity, storytelling and history, ideology and reality. Braun's text is no longer rooted in a teleological conception of history and ideological certainty. The contradiction and confusion of the historical events since the collapse of the GDR find their expression in the entangled layers of this complex narrative, which derives much of its persuasive appeal from its wide range of comic elements.
Dynamically Feasible Motion Planning for Micro Air Vehicles Using an Egocylinder

Onboard obstacle avoidance is a challenging, yet indespensible component of micro air vehicle (MAV) autonomy. Prior approaches for deliberative motion planning over vehicle dynamics typically rely on 3-D voxel-based world models, which require complex access schemes or extensive memory to manage resolution and maintain an acceptable motion-planning horizon. In this paper, we present a novel, lightweight motion planning method, for micro air vehicles with full configuration flat dynamics, based on perception with stereo vision and a 2.5-D egocylinder obstacle representation. We equip the egocylinder with temporal fusion to enhance obstacle detection and provide a rich, 360\(^{\circ }\) representation of the environment well beyond the visible field-of-regard of a stereo camera pair. The natural pixel parameterization of the egocylinder is used to quickly identify dynamically feasible maneuvers onto radial paths, expressed directly in egocylinder coordinates, that enable finely detailed planning at extreme ranges within milliseconds. We have implemented our obstacle avoidance pipeline with an Asctec Pelican quadcopter, and demonstrate the efficiency of our approach experimentally with a set of challenging field scenarios.
Form and formulation: Examining the distinctiveness of body image constructs in treatment-seeking patients with binge-eating disorder.

OBJECTIVE Body-image disturbance is a core aspect of eating disorders, yet the clinical manifestations of individuals' weight and shape concerns are complex, vary considerably, and are poorly understood by clinicians and researchers. This study aimed to distinguish different aspects of body-image disturbance-including weight/shape dissatisfaction, weight/shape overvaluation, weight/shape preoccupation, and fear of weight gain-in patients with binge-eating disorder (BED). Examining how each specific body image construct relates to biopsychosocial features of BED could contribute to the refinement of conceptualization and treatment planning. METHOD The current study assessed body-image disturbance and eating-disorder psychopathology in 748 treatment-seeking patients with BED using established investigator-based interviews reliably administered by doctoral clinicians. RESULTS The 4 body image constructs, although related to one another, showed some important similarities in associations with biopsychosocial clinical features, as well as some important distinctions. The relation between overvaluation and self-esteem was, as conceptualized, more strongly negative than for other body image variables, and preoccupation was more associated than other body image variables with eating concerns. Biopsychosocial features of BED were associated with different forms of body-image disturbance, but associations of body image variables with body mass index (BMI) were not significant and associations with binge-eating frequency did not differ across body image variables. CONCLUSION Manifestations of body-image disturbance in BED are complex and understanding the distinctions between different body image constructs can contribute to treatment formulation. (PsycINFO Database Record
A Redox Role for the [4Fe4S] Cluster of Yeast DNA Polymerase δ

A [4Fe4S]2+ cluster in the C-terminal domain of the catalytic subunit of the eukaryotic B-family DNA polymerases is essential for the formation of active multi-subunit complexes. Here we use a combination of electrochemical and biochemical methods to assess the redox activity of the [4Fe4S]2+ cluster in Saccharomyces cerevisiae polymerase (Pol) δ, the lagging strand DNA polymerase. We find that Pol δ bound to DNA is indeed redox-active at physiological potentials, generating a DNA-mediated signal electrochemically with a midpoint potential of 113 ± 5 mV versus NHE. Moreover, biochemical assays following electrochemical oxidation of Pol δ reveal a significant slowing of DNA synthesis that can be fully reversed by reduction of the oxidized form. A similar result is apparent with photooxidation using a DNA-tethered anthraquinone. These results demonstrate that the [4Fe4S] cluster in Pol δ can act as a redox switch for activity, and we propose that this switch can provide a rapid and reversible way to respond to replication stress.
Problems with Possible Worlds

In 1971, on my first day as a faculty member at the University of Massachusetts, Vere Chappell told me that the corridors were buzzing with talk of possible worlds, and that Ed Gettier could almost always be found wherever such talk was going on. Chappell was certainly right. These discussions continued over the years and, at one time or another, included Fred Feldman, Bob Sleigh, Terry Parsons, Herb Heidelberger (now deceased), myself, and too many graduate students to mention by name. But Gettier was without doubt the central figure. Naturally, he still loves to think about possible worlds and will discuss them at the drop of a hat.
Selected Topics in Artificial Intelligence for Planning and Scheduling Problems, Knowledge Acquisition, and Machine Learning

Application of artificial intelligence techniques to planning and scheduling problems are briefly reviewed, issues involved in knowledge acquisition are discussed, and methods for machine learning are introduced.
Impact of SLCO1B3 single nucleotide polymorphisms (SNPs) on outcomes in patients with castration resistant prostate cancer (CRPC) treated with docetaxel.

e17027Background: The organic anion transport polypeptide SLCO1B3 is expressed on both hepatocytes and CRPC tumor cells and mediates docetaxel transport. Preclinically, loss of expression of SLCO1B...
Di- and trivalent chromium bis(pyrazol-3-yl)pyridine pincer complexes with good leaving groups

Abstract The consequences of installing two versions of a potentially redox active pincer ligand on Cr(III) and Cr(II) are described, and reveal influence of the Jahn-Teller effect. The ligand involves two pyrazole rings attached by pyrazole carbons to the ortho positions of pyridine, thus creating two 1,4-diazabutadiene moieties. In one version, each pyrazole carries an NH proton (H2L), while a comparison version (LMe) involves methyl in place of the two weakly acidic protons, to identify the impact of hydrogen bonding. Complexes synthesized include (H2L)CrX3, where X Cl, triflate and nitrate, (LMe)CrCl3 and (LMe)Cr(OTf)3, together with the divalent metal complexes (H2L)CrCl2, (LMe)CrCl2 and (LMe)Cr(OTf)2. Cyclic voltammetry establishes the relationship between the tri- and divalent triflate complexes of LMe, and DFT calculations indicate further reduction of the latter occurs at the LMe ligand. Nitrate is shown to be a stronger ligand than triflate to Cr(III) here. NaBArF24 in THF removes only one chloride from (H2L)CrCl2, to give square pyramidal [(H2L)CrCl(THF)]+.
Estrogen induced apoptosis in breast cancers is phenocopied by blocking dephosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) protein.

Approximately 30% of aromatase-inhibitor-resistant, estrogen receptor-positive patients with breast cancer benefit from treatment with estrogen. This enigmatic estrogen action is not well understood and how it occurs remains elusive. Studies indicate that the unfolded protein response and apoptosis pathways play important roles in mediating estrogen-triggered apoptosis. Using MCF7:5C cells, which mimic aromatase inhibitor resistance, and are hypersensitive to estrogen as evident by induction of apoptosis, we define increased global protein translational load as the trigger for estrogen-induced apoptosis. The protein kinase RNA-like endoplasmic reticulum kinase pathway was activated followed by increased phosphorylation of eukaryotic initiation factor-2 alpha (eIF2α). These actions block global protein translation but preferentially allow high expression of specific transcription factors, such as activating transcription factor 4 and C/EBP homologous protein that facilitate apoptosis. Notably, we recapitulated this phenotype of MCF7:5C in two other endocrine therapy-resistant cell lines (MCF7/LCC9 and T47D:A18/4-OHT) by increasing the levels of phospho-eIF2α using salubrinal to pharmacologically inhibit the enzymes responsible for dephosphorylation of eIF2α, GADD34, and CReP. RNAi-mediated ablation of these genes induced apoptosis that used the same signaling as salubrinal treatment. Moreover, combining 4-hydroxy tamoxifen with salubrinal enhanced apoptotic potency. IMPLICATIONS: These results not only elucidate the mechanism of estrogen-induced apoptosis but also identify a drugable target for potential therapeutic intervention that can mimic the beneficial effect of estrogen in some breast cancers.
Towards the Micro-Foundations of Knowledge-Based Advantage: The Concept of Knowledge-Use Capability

The Knowledge-Based View of firms (KBV) views knowledge as the principal productive resource of the firm. While this view has generated significant scholarly work since its inception, less attention has been focused on the elemental social processes that lead to knowledge-based advantage. In this paper, I first present the findings of an inductive study in a single, mature, manufacturing industry (the US foundry industry). The study helped me develop the concept of “knowledge-use capability” that represents the micro-level practices that managers of firms in the industry engage in for adapting and expanding knowledge while facing challenging day-to-day situations. I then use the findings from Study-1 to test generalizable propositions in a large scale survey-based Study-2 (in the same industry) involving the role of knowledge-use capability in enhancing the effectiveness of a firm’s knowledge assets in generating incremental and radical innovation.
Knowledge and Beliefs of EMS Providers toward Lights and Siren Transportation.

INTRODUCTION: The use of warning lights and siren (WLS) increases the risk of ambulance collisions. Multiple studies have failed to demonstrate a clinical benefit to the patients. We sought to investigate the degree to which providers understand the data and incorporate it into their practice. METHODS: The authors distributed an anonymous survey to prehospital providers under their medical direction at staff and quality assurance meetings. The surveys asked the providers' degree of agreement with four statements: transport with lights and siren shortens transport times; transport with lights and siren improves patient outcome; transport with lights and siren increases the risk of collision during transport; and transport with lights and siren reduces the utilization of "mutual aid" service. We compared responses between providers who had been in prior ambulance collisions and those who had not. RESULTS: Few responses reached statistical significance, but respondents tended towards agreement that WLS use shortens transport times, that it does not improve outcomes, and that it increases the risk of collision. Despite the overall agreement with the published literature, respondents report >80% of transports are conducted using WLS. CONCLUSION: The data demonstrate the surveyed providers are aware of the risk posed by WLS to themselves, their patients, and the public. Nevertheless, their practice in the absence of rigid protocols suggests they disregard this knowledge. Despite a large number of prior ambulance collisions among the surveyed group, a high number of transports are conducted using WLS. Language: en
The spectrum of a solenoid

Given a sequence of regular finite coverings of complete Riemannian manifolds, we consider the covering solenoid associated with the sequence. We study the leaf-wise Laplacian on the covering solenoid. The main result is that the spectrum of the Laplacian on the covering solenoid equals the closure of the union of the spectra of the manifolds in the sequence. We offer an equivalent statement of Selberg's 1/4 conjecture.
Examining the Information Content of Residuals from Hedonic and Spatial Models Using Trees and Forests

Machine learning algorithms such as neural nets, support vector machines, and tree-based techniques (classification and regression trees) have shown great success in dealing with a number of complex problems (Hastie et al. 2009). However, real estate data exhibit both temporal dependence and high levels of spatial dependence (Pace et al., International Journal of Forecasting16(2), 229–246, 2000; LeSage and Pace 2009) that may make it harder to use with off-the-shelf machine learning procedures. We examine tree-based techniques (CART, boosting, and bagging) and compare these to spatiotemporal methods. We find that bagging works well and can give lower ex-sample residuals than global spatiotemporal methods, but do not perform better than local spatiotemporal methods.
The role of race and ethnicity in views toward and participation in genetic studies and precision medicine research in the United States: A systematic review of qualitative and quantitative studies.

BACKGROUND Racial/ethnic minority populations in the United States are consistently underrepresented in genetic research. Large-scale public participation is required to ensure discoveries from precision medicine research are applicable to everyone. To evaluate views toward and facilitators of participation among minority populations in the United States, we conducted a systematic review of literature. METHODS Six databases were searched for articles published from 2005 to 2018 assessing minority populations' views and/or willingness to participate in genetic research. A thematic framework was applied to extracted data to synthesize findings, and the Socio-Ecological Model was used to evaluate papers. RESULTS Review of 2,229 titles and abstracts identified 27 papers (n = 8 qualitative, n = 19 quantitative). Themes included knowledge of genetics, engagement in research, facilitators and barriers to participation, and cultural considerations. Understanding of genetics was low, yet the majority of participants were willing to participate in genetic research among all populations included in the literature (range: 57%-97%). Recommendations for research included utilizing community-based participatory approaches, evaluating participants' informational needs, incentivizing participation, and providing direct benefits (e.g., genetic test results). CONCLUSION Results could influence future study designs that incorporate all levels of the Socio-Ecological Model and better meet the needs of underrepresented groups, thereby ensuring precision medicine research findings are applicable to all.
Situs inversus totalis in a 96-year-old female cadaver: evidence pointing toward the two-cilia model

Situs inversus totalis is a complete transposition of the thoracic and abdominal organs and represents one of many laterality defects within the heterotaxy spectrum. Here we report a case of a 96-year-old female cadaver with situs inversus. Examination of the respective computed tomography images revealed situs inversus totalis with dextrocardia. A detailed dissection demonstrated the transposition of the viscera and confirmed complete reversal of the visceral organs without major anomalies. In order to gain insight into the etiology of the present anatomical anomaly, we performed a screen for the putative genetic variants in the coding regions (exomes) of the DNA extracted from the cadaveric tissue using Next Generation Sequencing (NGS) technology. The analysis of the data revealed the presence of genetic variants, DVL1, DNAH9, PKD1, and TRPV4, that are closely associated with the regulation of cilia structure and function. Aberrant cilia function has been proposed by other investigators to be a major cause of laterality defects. Because DNAH9 mutation could be linked to the impairment of motile primary cilia function and mutations in DVL1, PKD1, and TRPV4 to that of non-motile primary cilia, our data could provide evidence in support of the two-cilia model where a synergistic functioning of both cilia types is required for a proper activation of the asymmetrical Nodal cascade in the left lateral plate mesoderm thereby assuring a typical and complete asymmetrical patterning of visceral organs.
The Stoics on Lekta: All There Is to Say

Ada Bronowski’s The Stoics on Lekta: All There Is to Say offers a comprehensive reconstruction of the role of lekta in Stoic philosophy. Indeed, as one works one’s way through 496 pages, it is hard...
Staphylococcus aureus, Antibiotic Resistance, and the Interaction with Human Neutrophils

Significance: Staphylococcus aureus is among the leading causes of bacterial infections worldwide. The high burden of S. aureus among human and animal hosts, which includes asymptomatic carriage an...
Soil and Environment

Soil is a blend of natural issue, minerals, gases, fluids, and life forms that together help life. Earth’s collection of soil, called the pedosphere, has four significant capacities: as a vehicle for plant development; as a method for water stockpiling, supply and cleaning; as a modifier of Earth’s air; and, as a territory for living beings.
Metastatic melanoma presenting as a breast mass – role of radiologist as a clinician

Breast tissue can be the host of not only many benign and malignant tumors but can also be a metastatic site for various tumors such as leukemia, lung cancer, and melanoma. This report describes an unusual case of a 43-year-old female who presented with a new palpable breast lump and several similar extramammary lumps on her skin. A melanoma panel, consisting of S100, HMB45, and Melan-A stains, was included in the pathology evaluation due to diagnostic suspicion of the radiologist and revealed metastatic melanoma. This case highlights the importance of detailed history and relevant physical exam as well as clinical and imaging correlation. It serves as a reminder to radiologists to include metastatic melanoma in the differential of suspicious subcutaneous breast masses, especially in patients with multiple subcutaneous lumps in the body or abnormal skin findings.
ID/HIV Physician Ambassadors: Advancing Policy to Improve Health.

ID/HIV physicians and other healthcare professionals advocate within the healthcare system to ensure adults and children receive effective treatment. These advocacy skills can be used to inform domestic and global infectious diseases policies to improve healthcare systems and public health. ID/HIV physicians have a unique frontline perspective to share with federal policymakers regarding how programs and policies benefit patients and public health. Providing this input is critical to the enactment of legislation that will maximize the response to infectious diseases. This article discusses the advocacy of ID/HIV physicians and other healthcare professionals in federal health policy. Key issues include funding for ID/HIV programs; the protection of public health and access to health care; improving research opportunities; and advancing the field of ID/HIV, including supporting the next generation of ID/HIV clinicians. The article also describes best practices for advocacy and provides case studies illustrating the impact of ID/HIV physician advocacy.
Electronic whiteboard implementation as a quality management tool optimizes IVF laboratory standardization and improves clinical outcomes

To test whether an electronic whiteboard in the IVF laboratory increases the likelihood that critical evaluation procedures are performed within optimum pre-set time ranges. A retrospective cohort study of oocyte retrievals in our IVF clinic between 06/01/2012 and 05/31/2018 was included. The electronic whiteboard was introduced on 04/06/2014. Prior to implementation, embryologists strived to adhere to the set evaluation times without a formal guide. The primary outcomes were the proportion of embryologist evaluations performed in optimum time ranges and the proportion of usable embryos per patient. A total of 4645 retrievals met inclusion criteria. Implementation of the whiteboard was associated with (1) an increase in the proportion of fertilization checks performed within the optimum time range for ICSI cycles (+ 5.1%, RR = 1.06, CI = 1.02–1.10); (2) an increase in the proportion of day 3 evaluations performed within the optimum time range, whether assisted hatching was performed (+ 23.6%, RR = 1.48, CI = 1.36–1.60) or not (+ 13.8%, RR = 1.23, CI = 1.12–1.35); and (3) an increase in the proportion of day 5 evaluations within the optimum time range (+ 15.5%, RR = 1.23, CI = 1.12–1.35). Additionally, the mean number of usable embryos per patient increased from 2.8 to 4.5 after the whiteboard was implemented (RR = 1.25, CI = 1.19–1.31). The use of an electronic whiteboard that posts optimum times for performing critical procedures significantly increases the proportion of evaluations that occur within these ranges. Such improved standardization led to positive downstream effects on the number of usable embryos per patient. We suggest that electronic whiteboard implementation driven by real-time data collection should be considered in all IVF laboratories.
The Examination of Cultural Values and Social Media Usages in China

Both social media usage statistics and recent studies outlined the importance for marketers to tap into China’s massive market with rapid growth rate. However, there is limited research focusing on investigating and explaining how the underlying values contribute to the social media usage behavior change. This research is aimed to fill the gap by examining the effect of cultural values on social media usage (e.g., shopping, interaction and information sharing) in China. It also explores the mediating effect of materialism on the relationship between cultural values and social media usage, along the male and female gender categories. While the size and scale of China’s social media market is astonishing, its market composition varies considerably from the rest of the world due to the Chinese government’s Internet censorship. As the study of major Chinese social media sites remains largely unexplored in the literature, this study studied the usage on different social media platforms in China. The survey were conducted online in China in 2018, and a total of 600 usable samples (n = 300 for males; n = 300 for females) were obtained. A principal components factor analysis with quartimax rotation was conducted in this study for a scale reduction purpose. Five cultural dimensions, namely power distance, collectivism/individualism, uncertainty avoidance, masculinity/femininity, and long-term/short-term orientation, were obtained. Then, regression analyses were used to test the hypotheses on main and mediating effects for both male and female social media users. The hypotheses were partially supported. The following summarizes major findings: 1) a significant and substantial effect of materialism on social media usages, as well a significant and moderate effect of cultural values on materialism were observed in this study; 2) the results showed that higher levels of collectivism predict higher levels of social media usage for the purpose of shopping, interaction and sharing information; 3) this study found, only for female users, a positive effect of long-term orientation on social media usage for the purpose of shopping, interaction and sharing information; 4) this study only identified one negative relationship, which is the relationship between power distance and using social media for the purpose of interaction for male users; 5) This study found users in China mainly use social media for information sharing and shopping, but not interaction purpose. Meipai (The Flickr of China), Zhihub(The Quora of China), and Tudou Youku (Youtube of China) were the top three social media sites used to share information such as photos, videos, and knowledges. On the other hand, Baidu Tieba (A Search Engine Forum), Tencent QQ (Popular Instant Messaging App) and Sina Weibo (Twitter of China) were the top 3 platforms people used to research and find product information or shop directly.
Learning DNF in time 2 õ ( n 1/3 )

Using techniques from learning theory, we show that any s-term DNF over n variables can be computed by a polynomial threshold function of degree O(n1/3 log s). This upper bound matches, up to a logarithmic factor, the longstanding lower bound given by Minsky and Papert in their 1968 book Perceptrons. As a consequence of this upper bound we obtain the fastest known algorithm for learning polynomial size DNF, one of the central problems in computational learning theory.
Longitudinal Control of a Platoon of Vehicles with no Communication of Lead Vehicle Information

Evaluates the performance of longitudinal control laws with no communication of lead vehicle information. After using exact linearization methods, the authors propose a linear control law for each vehicle which uses only the information from the preceding vehicle in the platoon.
Rheumatoid lung disease. A case report which includes respiratory function studies and a lung biopsy.

Summary The clinical course of a man with rheumatoid arthritis is described. In the twelfth year of the disease he developed bilateral pleural effusions. Pulmonary function tests showed that the pulmonary diffusing capacity was greatly reduced. Lung biopsy demonstrated pleural and sub-pleural necrobiotic nodules of the rheumatoid type and also revealed extensive thickening and infiltration of the interalveolar septa. The significance of the special investigations in relation to the two distinct types of rheumatoid lung involvement has been discussed.
From Yoda to Sackett: the future of psychiatry medical student education.

The authors discuss approaches to curricular goals, methods, and assessments in the education of medical students in psychiatry. Using current educational principles and opinions on curricular reform in medical student education, an outline for a core curriculum and an individualized approach to medical student education were developed. A curricular outline addressing both content and organization was developed for all students as well as those specifically entering clinical psychiatry, neuroscience research, and primary care. In addition to a standard core curriculum there should be a tailored approach for certain subsets of students. The core curriculum should be an “ideal minimum” that recognizes the importance of evidence based medicine and is strategically planned and learner focused.
Partial occlusion of a Blalock-Taussig shunt in a 3-month-old with systemic fungal infection.

A 3-month-old male patient was born at 34 weeks’ gestation weighing 1.3 kg with an antenatal diagnosis of severe mitral stenosis, hypoplasia of the left ventricle, juxtaposition of the left atrial appendages, aorta arising anteriorly from the right ventricle, and pulmonary atresia. Following initial palliation with atrial septostomy, he underwent hybrid stenting of the ductus arteriosus. Three days after the stent placement, progressive stenosis of the pulmonary end of the ductus led to a reduction in oxygen saturations and he underwent placement of a 3.5-mm modified right Blalock–Taussig (BT) shunt and partial ligation of the stented patent ductus arteriosus. At discharge, his oxygen saturations were in the upper 80s. He was readmitted 3 days later with a history of lowgrade fever and intermittent oxygen desaturations. Urine cultures grew Candida. Further workup revealed severely enlarged kidneys and, subsequently, the patient underwent right nephrostomy tube placement for partial obstructive uropathy secondary to fungal balls. An echocardiogram revealed patency of the BT shunt, although the proximal area was attenuated with an echogenic mass seen within the lumen of the shunt suggestive of thrombus/vegetation formation (Fig. 1). Emergency catheterization was performed to attempt to reestablish full patency of the BT shunt, as previously reported [1, 2]. The findings identified on echocardiography were confirmed on angiography with distal narrowing of the BT shunt also seen (Fig. 2a). The BT shunt was balloon-dilated with a 5-mm coronary balloon with resolution of the intraluminal mass and improvement in the proximal and distal stenoses as demonstrated by angiography (Fig. 2b) and echocardiography (Fig. 3). Of note, stent placement was not considered, as the narrowing of the BT shunt was at the anastomotic site of the shunt to the brachiocephalic artery and stenting would have compromised the brachiocephalic artery. The infant’s oxygen saturations improved dramatically from 55% preprocedure to 80% following the intervention. This report highlights the benefit of detailed echocardiography in evaluating patients with intermittent oxygen desaturations in the setting of a BT shunt.
Elemental and chemical concentration in peach tree short life and healthy trees

Abstract Elemental concentrations of N, P, K, Ca, Mg, Fe, Al, Zn, Mn, and Cu in peach tree short life (PTSL) trees were compared to concentrations in apparently healthy trees in the same orchard. Leaf and stem concentration of K were significantly less and concentrations of Fe and Al were significantly greater in PTSL trees than healthy trees. Leaf concentrations of Ca and Mg and stem concentrations of N, P, and Cu were also significantly less in PTSL trees than healthy trees. Increased levels of Fe and Al and a K:Fe ratio of less than 150:1 in the leaves and stems was associated with PTSL. There were no detected differences in prunasin, amino acid, or sugar content of PTSL and healthy trees in leaf and stem samples, but significant differences in elemental content suggest some type of stress on the root system of PTSL trees.
Issues in Bottleneck Detection in Multi-Tier Enterprise Applications

In this work, the performance of various machine learning classifiers with regard to bottleneck detection in enterprise, multi-tier applications governed by service level objectives is described. Specifically, in this paper, it demonstrates the effectiveness of three classifiers, a tree-augmented Naive Bayesian network, a J48 decision tree, and LogitBoost, using our bottleneck detection process, which delves into a new area of performance analysis based on the trends of metrics (first order derivative) rather than the metric value itself. Furthermore, the efficiency of each classifier by measuring the convergence speed, or the number of staging trials required in order to provide positive results is illustrated. Finally, the effectiveness of the classifiers used in the bottleneck detection process as each classifier strongly identifies the enterprise system bottleneck
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases

B-lymphoma Moloney murine leukaemia virus insertion region-1 (BMI1) is a member of the polycomb group of transcription repressors, which functions in stem cell maintenance and oncogenesis through the inhibition of the INK4A/ARF tumour suppressor locus. Overexpression of BMI1 is associated with poor prognosis in several human cancers, including breast cancer. We have previously shown that BMI1 collaborates with H-RAS to induce transformation of MCF10A human mammary epithelial cells through dysregulation of multiple growth pathways independent of the INK4A/ARF locus. In this study, we show that BMI1 collaborates with H-RAS to promote increased proliferation, invasion and resistance to apoptosis in vitro, and an increased rate of spontaneous metastases from mammary fat pad xenografts including novel metastases to the brain. Furthermore, in collaboration with H-RAS, BMI1 induced fulminant metastatic disease in the lung using a tail vein model of haematogenous spread through accelerated cellular proliferation and inhibition of apoptosis. Finally, we show that knockdown of BMI1 in several established breast cancer cell lines leads to decreased oncogenic behaviour in vitro and in vivo. In summary, BMI1 collaborates with H-RAS to induce an aggressive and metastatic phenotype with the unusual occurrence of brain metastasis, making it an important target for diagnosis and treatment of aggressive breast cancer.
Important Events in the Development of Academic Advising in the United States

The development of academic advising parallels the history of higher education and reflects decades of student personnel work. Changes in funding, curricula, students, and faculty roles have all af...