cssi/SciSciGPT-SciSciNet huggingface dataset:
Talking to Clients About Money

This article offers practical suggestions for talking to clients about their bill, simply discussing the hourly rate is not sufficient.
Methods for structural health monitoring based on long-gauge and distributed fiber optic sensors

Fiber Optic Sensors (FOS) offer two unique strain sensing tools for Structural Health Monitoring (SHM) of civil structures and infrastructure: long-gauge sensors and truly distributed sensors, which enable global structural monitoring and integrity monitoring, respectively.
Investigation of Metal Free Naphthalocyanine Vapor Deposited on Au(111)

Naphthalocyanines (Ncs) are promising candidates for future components in electronic devices and applications. To maximize the efficiency of Nc devices, it is critical to understand their structural and electronic properties and how these are impacted by deposition methods. The formation of a metal free naphthalocyanine (H2Nc) self-assembled monolayer on a Au(111) crystal was investigated by scanning tunneling microscopy under ultra-high-vacuum conditions at room temperature. A rigorous purification and processing procedure was developed to produce high purity, low defect, and well-ordered monolayers. High-resolution STM images reveal epitaxial growth of H2Nc on Au(111) with the observed structure having a molecular spacing of 1.6 ± 0.05 nm, with molecules orientated slightly off (roughly 2.5°) the low density packing direction of Au(111). A commensurate structure having 4 molecules per unit cell and unit cell parameters of A = 3.25 ± 0.05 nm, B = 3.17 ± 0.05 nm, and α = 87.5 ± 2° is proposed. Orbital-med...
Influence of chemical coating combined with nanopatterning on alginate fouling during nanofiltration

Abstract This contribution describes a method to increase the fouling resistance of nanofiltration membranes by applying both a chemical coating and a nanoscale pattern to the membrane surfaces. A line and groove nano-pattern was applied by thermal embossing directly onto a commercial polyamide thin-film composite nanofiltration membrane. Poly(ethylene glycol) diglycidyl ether (PEGDE) was reacted onto the patterned membrane surfaces by an epoxide ring opening reaction with unreacted carboxyl groups on the polyamide selective layer. Membrane performance was evaluated by measuring flux and salt rejection using a magnesium sulfate solution and by measuring flux reduction using an alginate solution. Surface characterization showed successful patterning and chemical modification of the membrane surface. Flux and salt rejection properties were unaffected by patterning the polyamide membrane surface directly. The fouling results show that combining line and groove nano-patterning with PEGDE chemical modification yields a membrane that is more resistant to fouling than either method alone.
Effect of Hydrogen-Enriched Gas on Reducibility and Reduction-Disintegration of Sinters

Iron and steel industry is one of the largest CO_2 source among industrial processes,accounting for about8%of global total CO_2 emission.Hydrogen-enriched reduction in blast furnace is an innovative technology to responding to requests for further reduction of CO_2 emission and sustainable development on a global scale.The effects of hydrogen-enriched gas on reducibility and reduction-disintegration are investigated in present work.The experimental results show that.Case 1:when H_2 content increases,equivalent CO content decreases.When H_2content increases from 0%to 12%,the reduction disintegration index(RDl i.u) of sinter decreases about 1%-2%.Case2:when H_2 content increases,the other gases,e.g.CO,CO_2 and N_2,decrease proportionally.RD1_(-3.15) increases about1.5%-2.5%when H_2 content increases from 0%to 12%.When H_2 content increases from 0%to 12%,the reducibility index(R_1) increases from 72.56%to 94.97%.Therefore,hydrogen-enriched gas will be an important role in improving the raw materials' metallurgical properties,and eventually in reduction of CO_2 emission.
Analysis of Peasants' Subjectivity in the View of Planning Urban-rural Economic and Social Development as a Whole

"Planning Urban-rural Economic and Social Development As a Whole" is the "Stage of Development","Pivotal Time" and "Crucial Phase" of Chinese society nowadays.During the implementation of this systematic engineering,many key element factors of practice should be combined together and pushed forward cooperatively.But for the moment,peasants don't have enough judgment to the reality and lack subjectivity;also,their requirement of subjectivity can't be expressed sufficiently and their conscious impetus can't be exerted.These lead to the consequence that their creativity as historic propellent can't be exerted sufficiently.If we want to enable the peasants to exert their subjectivity during the process of "Planning Urban-Rural Economic and Social Development As a Whole",we should first analyze the peasants' subjectivity,dig their power of self-liberating,protect the right of reasonable flowage between rural and urban areas,fulfill the education requirement of knowledge and craftsmanship and improve the equality of social service and social status.
"False inhibition" of demand pacemaker due to leakage of fluid into the pacemaker lead socket.

“False inhibition” of a demand pacemaker usually occurs with a microfracture of the lead system resulting in a galvanic potential at the site of the fracture or with sensing of myopotential with exercise. An increase in the slope of the leading half edge of the pulse contour is generally considered diagnostic of lead fracture. We report the case of a patient in whom “false inhibition” at rest and an increase in the slope of the leading half edge of the pulse contour were caused by leakage of fluid into the pacemaker lead socket.
How particles can emerge in a relativistic version of Bohmian Quantum Field Theory

It is shown how bosonic material particles can emerge from a covariant formulation of de Broglie-Bohm theory. The formulation is based on the work of Nikolic. Material particles are continuous fields, formed as the eigenvalue of the Schrodinger field operator, evaluated along a Bohmian trajectory.
Intrusion Detection Using Deep Belief Network and Extreme Learning Machine

Security threats for computer networks have increased dramatically over the last decade, becoming bolder and more brazen. There is a strong need for effective Intrusion Detection Systems IDS that are designed to interpret intrusion attempts in incoming network traffic intelligently. In this paper, the authors explored the capabilities of Deep Belief Networks DBN-one of the most influential deep learning approach-in performing intrusion detection after training with the NSL-KDD dataset. Additionally, they examined the impact of using Extreme Learning Machine ELM and Regularized ELM on the same dataset to evaluate the performance against DBN and Support Vector Machine SVM approaches. The trained system identifies any type of unknown attack in the dataset examined. In addition to detecting attacks, the proposed system also classifies them into five groups. The implementation with DBN and SVM give a testing accuracy of about 97.5% and 88.33% respectively with 40% of training data selected from the NSL-KDD dataset. On the other hand, the experimental results show around 98.20% and 98.26% testing accuracy respectively for ELM and RELM after reducing the data dimensions from 41 to 9 essential features with 40% training data. ELM and RELM perform better in terms of testing accuracy upon comparison with DBN and SVM.
The Effect of Testosterone Topical Solution in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel.

This study evaluated the effect of axillary administration of a 2% testosterone solution (Axiron®) in hypogonadal (HGN) men who had had a suboptimal response to treatment with a commercially available topical testosterone gel. HGN men averaging 57 years old, with a mean body mass index of 31.9 kg/m2 and median baseline testosterone level (T-level) of 185.2 ng/dL, who had failed to reach normal T-levels with a topical testosterone gel (Androgel 1.62%, Androgel, Testim, or Fortesta) were treated with a 2% testosterone solution until T-levels reached a normal range (from ≥300 to ≤1,050 ng/dL) or for up to 9 weeks. Outcomes included the cumulative percentage of men with a serum T-level in the normal range during treatment with Axiron and improvement in symptoms of low energy level and low sexual drive. During the study, 95% of HGN men (72/78) attained a T-level in the normal range. The median T-level at endpoint was 495.7 ng/dL, a threefold increase over baseline, p 35 kg/m2 ( n = 19) achieved T-levels in the normal range. Prior to treatment, over 61% of subjects (48/78) reported impairment in either energy level or sexual drive. After treatment (or testosterone normalization), energy level improved in 75% of subjects and sexual drive improved in 70%. Topical 2% testosterone solution is a safe and effective treatment for HGN men who have had a suboptimal response to previous treatment with topical testosterone gels.
Long Survival in Patients with Al Amyloidosis

Eighteen of 127 patients with AL amyloidosis seen before October 1984 were found to have survived 60 months or longer. For this study, a control patient matched for the nearest date of diagnosis was analyzed with each long survivor. Six male and 12 female patients comprised the long survivor group, compared to 10 males and 8 females in the control group. Median survival from diagnosis was 93.3 months (range 60.9-205.3) for the long survivors and 12.3 months (2.3-56.5) for the controls. The marked difference in survival could not be predicted by organ system involvement.
Capacity Evaluations in Older Adults: Neuropsychological Perspectives

Aging necessarily brings with it changes in one’s functional abilities, and this often occurs in the setting of declining cognition. Changes in mental capacities may be subtle, even almost imperceptible, or they may be so glaringly apparent that no one can deny their presence. Older adults with cognitive decline are clearly vulnerable, and this places them at greater risk for abuse and exploitation. Neuropsychologists are becomingly increasingly called upon to consult about such mental capacities in the elderly, to provide opinions to families and courts of law regarding one’s abilities to care for themselves as well as make decisions about their health care, finances and other important matters. In this chapter we discuss the role of the neuropsychologist in such capacity evaluations and provide an assessment framework for professionals who may be new to this interesting aspect of practice.
Presidential Address: Digital Media Use and the Experience(s) of Childhood: Reflections Across the Generations

Does media use define the experience of childhood? The present article, based on Jordan's Presidential Address at the International Communication Association's 66th annual conference, argues that while we often view media technologies as dividing generations, it is equally valuable to consider how they connect generations and enhance their well-being. It highlights the challenges of systematically studying youth and media in this way, particularly in an environment where “everyone's an expert” and judgments are based on personal experiences. The article concludes by arguing that as a field we must recognize that the experience of “childhood” is not monolithic. The study of media in children's lives must reflect the familial, economic, social, political, and geographic contexts in which they develop.
Christianity and the City of Man: From Retreat to Reform

The rise of Christianity and the fall of Rome prompted new thinking about the relationship between state and self. Augustine of Hippo openly doubted political obligation when it conflicted with religious obligation, and he described the earthly state as a curse. His thought is connected both to modern anarchism and to the public choice school of economics. Although Augustine would have established a theocracy, one can easily imagine the establishment of a Christian anarchism instead, in the manner of Leo Tolstoy.
Part 3: College Student Development

ABSTRACTYoung adults in college grow cognitively, socially, and emotionally. Educational psychologists have described students’ growth with models that include advancing stages in ways of knowing, aka epistemic beliefs. The typical progression of epistemic beliefs begins with dualism and progresses to multiplicity, then to relativism, and finally to commitment in relativism. Freshmen almost all have a dualist or multiplist way of knowing and do not progress to relativism without guidance and instruction. This normal evolution in ways of knowing has important implications for teaching information literacy within the Association of College and Research Libraries’ (ACRL’s) Framework.
Cold Agglutinin Syndrome in Post-Liver Transplant Patients on Tacrolimus.

Following liver transplantation, patients require immunosuppressive medications to prevent graft rejection. However, these drugs can have significant side effects including severe anemia. Tacrolimus is now commonly used in pediatrics patients after liver transplantation. Case reports indicate that tacrolimus rarely can cause microangiopathic hemolytic anemia and also hemolytic anemia due to cold reactive IgM antibodies (cold agglutinin disease). We have seen 4 patients with symptomatic cold agglutinins thought to have been triggered by tacrolimus. Four patients, 6 to 26 months post-ABO-compatible liver transplant, presented with severe anemia (hemoglobin
Violation of collision limit in recently published reaction models

Abstract Twenty reaction models published in five consecutive issues of Combustion and Flame in 2015 and 2016 were screened for the occurrence of collision limit violations. It was found that among the 20 models tested, 15 of them contain either considerable numbers of rate coefficients that exceed their respective collision limits or reactions exceeding the collision limit in a considerable manner. In the worst case, the rate coefficient exceeds the collision limit by 73 orders of magnitude. It is proposed that computational tools should be made available for authors to conduct the same rate coefficient screening. A standard report generated by such screening tools should be submitted as a part of the supplementary material for a manuscript in which one or more reaction models are proposed; reviewers should consult the report in forming his/her opinions about the quality of the reaction model during manuscript review.
Female Leadership in the Upper Echelons and Corporate Diversity Misconduct

The under-representation of women in senior executive and board of director positions has attracted a great deal of attention among scholars and practitioners alike. The predominant discussion invo...
Effect of Cord Blood Magnesium Level at Birth on Non-neurologic Neonatal Outcomes.

Objective We examined the effects of magnesium sulfate on non-neurologic neonatal outcomes with respect to cord blood magnesium level. Study Design We conducted a secondary analysis of the Maternal-Fetal Medicine Units Beneficial Effects of Antenatal Magnesium (MFMU BEAM) trial comparing the upper and lower quintiles of cord blood magnesium level. Outcomes included cerebral palsy (CP), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), and assessments of mental and motor disability. Logistic regression was used to estimate adjusted odds ratios (aORs) of each outcome, controlling for gestational age (GA), birth weight, and treatment group (TG). Results A total of 1,254 women of the 2,444 included in the BEAM trial had cord blood magnesium levels recorded. GA and birth weight were lower and TG was more common in the upper quintile cohort (p Conclusion Higher cord blood magnesium levels do not appear to have adverse non-neurologic effects on the neonate and may demonstrate improvement in neurologic outcomes.
Optimal design of a microring cavity optical modulator for efficient RF-to-optical conversion.

The efficiency of optical sideband generation with a microring resonator modulator as a function of modulator parameters is studied taking into account the photon dynamics inside the resonator. The best achievable modulation efficiency is determined for any choice of the resonator intrinsic quality factor, and analytic solutions for the optimum modulator parameters, namely the coupling coefficient and the detuning between the frequencies of the input laser light and the microring resonance, are provided. This analysis is carried out both for a narrowband RF signal, in which case the modulator is optimized for the center frequency of this signal, and for wideband signals, when high conversion efficiency over a wide range of RF frequencies is desired. The obtained results are expected to be useful coherent optical links, direct detection RF receivers, and optical wavelength converters
Generalized pustular psoriasis: a review and update on treatment

Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. The interleukin family and caspase recruitment domain family have been implicated in its pathogenesis. Other forms of pustular psoriasis include impetigo herpetiformis, palmoplantar pustular psoriasis, annular pustular psoriasis and acrodermatitis continua of Hallopeau. Treatment is not well established, but includes the use of retinoids, methotrexate, cyclosporine, corticosteroids, TNF-alpha inhibitors, topical therapy and phototherapy. The use of TNF-alpha inhibitors may result in the formation of antidrug antibodies and should be administered with methotrexate.
Qualitative study on chinese students’ perception of U.S. University life

This qualitative research was conducted on Chinese international students preparing to study in the United States about their expectation and perception of American universities. It explored motivation for pursuing degrees in the United States, expectations of life in the United States, and plans post-graduation. Findings suggest that these students foresee U.S. classes to be rigorous due to two notable barriers: English proficiency issue and difference in learning environment. Furthermore, the students promoted desires to build relationships with domestic students but already internalized beliefs that this action was unlikely. They presumed that most networking would occur with co-nationals due to comfort and ease. Finally, parental expectations emerged as a significant factor that influence Chinese international students’ desire to study in the United States and post-graduation plans.
Differences in social evaluations and their effects on employee job attitudes and turnover intentions in a restaurant setting

The current research examines the effects of employees' social evaluations of their coworkers and managers on job satisfaction, organizational commitment, and turnover intentions. This study enhanc...
Linking a Total Ankle Arthroplasty Registry to Medicare Inpatient Claims without Unique Identifiers.

BACKGROUND Linking clinical registries to administrative claims data enables researchers to capitalize on the specific strengths of each data source with respect to the depth, breadth, and completeness of information. The objectives of this study were to link a health-system-based orthopaedic surgery registry to U.S. Medicare claims data without the use of unique identifiers and to assess the representativeness of the linked records. METHODS The registry included clinical data for patients ≥65 years of age who underwent elective, inpatient total ankle arthroplasty (TAA) in a single health system during the period of 2007 through 2012. Registry participants were identified within the Medicare data by linking registry procedures to TAA procedures within the claims data using a combination of procedure date, patient date of birth, and patient sex. We assessed the representativeness of the linked records by comparing them to both unlinked registry records and unlinked Medicare records for TAA procedures. Additionally, we described the availability of postsurgical data for linked records. RESULTS Of 360 TAA registry participants ≥65 years of age, 280 (77.8%) were matched to a Medicare record; 250 (89.3%) of those 280 participants were matched on the basis of a linking rule that required an exact match for procedure date, date of birth, and sex. The 280 linked records comprised 5.5% of all Medicare TAA procedures among beneficiaries ≥65 years of age enrolled in the fee-for-service Medicare program (n = 5,070). Compared with linked records, unlinked records were more likely to be for patients 65 to 69 years old, but the 2 groups were similar in terms of sex, body mass index, and availability of clinical measurements. Of the linked records, 214 (76.4%) had ≥3 years of postoperative follow-up claims data. CONCLUSIONS Linkage without unique patient identifiers between an orthopaedic registry and Medicare claims data is feasible, allows for assessment of representativeness, and creates a unique resource of longitudinal data for research.
Ethanol Production from Maize

The production of fuel ethanol from corn grain is widely carried out in the US, with total current production at 7 billion gallons. This may soon reach 10 billion gallons or more. This chapter addresses the potential of fuel ethanol as an additional source of product based on utilization of the cellulosic (non-food) portions of maize, and in particular the pericarp, cobs, stalks and leaves of the corn plant. An analysis of the composition of corn, and possible processing schemes that transform the cellulosic portions to ethanol are addressed. Technologies for the bioprocessing of cellulose to ethanol, as well as the impact of cellulose utilization on supplementing corn ethanol, are presented. Stefan Schwietzke Laboratory of Renewable Resources Engineering, Purdue University, Potter Engineering Center, 500 Central Drive, West Lafayette, IN 47907, USA Youngmi Kim, Eduardo Ximenes Department of Agricultural and Biological Engineering, Purdue University, 225 South University Street, West Lafayette, IN 47907, USA Nathan Mosier Laboratory of Renewable Resources Engineering, Purdue University, Potter Engineering Center, 500 Central Drive, West Lafayette, IN 47907, USA Department of Agricultural and Biological Engineering, Purdue University, 225 South University Street, West Lafayette, IN 47907, USA Michael Ladisch Laboratory of Renewable Resources Engineering, Purdue University, Potter Engineering Center, 500 Central Drive, West Lafayette, IN 47907, USA Department of Agricultural and Biological Engineering, Purdue University, 225 South University Street, West Lafayette, IN 47907, USA Weldon School of Biomedical Engineering, Purdue University, 206 S. Intramural Drive, West Lafayette, IN 47907, USA e-mail: ladisch@purdue.edu A.L. Kriz, B.A. Larkins (eds.), Molecular Genetic Approaches to Maize Improvement 347 Biotechnology in Agriculture and Forestry, Vol. 63 c © Springer-Verlag Berlin Heidelberg 2009 348 Stefan Schwietzke et al.
The Tissue-Based Triad in Augmentation Mastopexy: Single-Stage Technical Refinements.

BACKGROUND The number of patients seeking augmentation mastopexy has increased over the last several decades. The conflicting goals of augmentation (tissue expansion) and mastopexy (tissue reduction) have led to higher revision rates, decreased patient satisfaction, and pending litigation. Some have even argued for staging of all augmentation mastopexy procedures. OBJECTIVES The goal of this study was to review the senior author's (W.P.A.) process-oriented approach to single-stage augmentation mastopexy and to detail the technical framework to produce reliable, reproducible, safe results in a 1-stage augmentation mastopexy. METHODS A prospectively collected patient database from January 2007 until January 2018 was reviewed. All single-stage augmentation mastopexy patients were evaluated, including patient demographics, operative details, complications, and outcomes. RESULTS A total of 251 patients were evaluated. Mean follow-up was 16.9 months, average patient age was 38.0 years, and average implant size was 285.8 cc. A total of 9 (3.6%) patients required reoperation and only 2 (0.8%) required explantation. Fourteen (5.6%) patients developed delayed wound healing that responded to local wound care alone. CONCLUSIONS Utilization of a safe and reliable processed approach to single-stage augmentation mastopexy is highly predictable with low reoperation rates. The technical refinements presented have led to increased consistency in delivering high-quality results to patients in a procedure fraught with challenges. LEVEL OF EVIDENCE: 4
Unmanned Aerial Auger for Underground Sensor Installation

Using an Unmanned Aerial Systems (UAS) to autonomously deploy soil sensors enables their installation in otherwise hard to access locations. In this paper, we present a system that integrates a UAS and a digging mechanism which can carry, secure, and install a small sensor into dirt effectively and efficiently. The integrated system includes 1) a low profile, light-weight, inexpensive auger mechanism, 2) a sensor carrying and deploying mechanism with low power consumption, and 3) sensors and software that control and evaluate the auger performance during digging. When tested on a suite of target soils and a target depth of 120mm, the system achieved a success rate of 100% for indoor tests and 92.5% for outdoors, verifying the potential of the approach.
A Case of Tumor of Follicular Infundibulum Involving the Vulva

Tumor of the follicular infundibulum or infundibuloma is a relatively rare benign adnexal tumor usually solitary and located in the head, neck, and trunk. Here we present a 70-year-old woman with a tender vulvar lesion. Histopathologic exam shows a well-circumscribed lesion with a subepidermal horizontally oriented, plate-like proliferation of pale appearing squamous epithelial cells with numerous points of connections with the overlying epidermis and peripheral palisading. Overall these histopathologic features are consistent with the diagnosis of tumor of follicular infundibulum involving genital skin.
Prophylactic pretransplant ganciclovir to reduce cytomegalovirus infection after hematopoietic stem cell transplantation.

Introduction Cytomegalovirus (CMV) reactivation remains a serious complication after allogeneic hematopoietic stem cell transplantation (HCT) occurring in 35-55% of HCT recipients. CMV reactivation can lead to adverse outcomes including end-organ damage and graft failure. Objective To reduce the incidence of CMV reactivation and disease by using prophylactic ganciclovir pretransplant. Methods We conducted a retrospective analysis of all recipient or donor CMV seropositive patients who received their first allogeneic HCT between 2012 and 2017. Ganciclovir was administered pretransplant (5 mg/kg twice daily IV from day −8 to day −2). Patients received valacyclovir or acyclovir starting day 0 until one-year posttransplant. Patients were monitored weekly with serum CMV PCR through Day 100 posttransplant. CMV reactivation was defined as a CMV viral load of more than 135 IU/ml, and was treated with preemptive therapy. All patients received GVHD prophylaxis with calcineurin inhibitor. Results Seventy-nine consecutive patients were treated. The median age was 58 years (range 20 to 72). The most common diagnoses were acute myeloid leukemia (49%) and acute lymphocytic leukemia (14%). Graft sources were matched related donor (30%), matched unrelated donor (35%), haploidentical (5%) and cord blood (29%). 43 patients (55%) received myeloablative conditioning. 36 patients (45%) received fludarabine based reduced intensity/nonmyeloablative conditioning. 24 patients (30%) had CMV reactivation with median time of reactivation of 47 days posttransplant (range 27 to 229). 22 out of the 24 (88%) patients required treatment for CMV reactivation with a median treatment duration of 37 days (range 14 to 315) and were treated with ganciclovir or foscarnet. The cumulative incidence of CMV reactivation at day 100 posttransplant was 27% with a 95% CI (18%-37%) depicted in Figure 1. There were no patients with biopsy proven CMV disease or deaths attributed to CMV reactivation or disease. The median time-to neutrophil recovery (≥500 K/ul) was 18 days and the median time to platelet recovery (≥20,000 K/ul) was 19 days. The incidence of acute GVHD Grades II-IV was 25 %. The incidence of significant kidney injury (Creatinine >2.5 mg/dL) was 2.4%. Conclusions The incidence of CMV reactivation, in this high-risk patient population, by day 100 of 27% with pretransplant ganciclovir may be improved compared to historical controls of 35-55%. The use of pretransplant ganciclovir was associated with no CMV disease and was safe, with low incidence of kidney damage. These data suggest that pretransplant ganciclovir with preemptive therapy for viral reactivation should be considered regardless of graft source. Future prospective randomized trials are needed to evaluate strategies for CMV prophylactic regimens.
Memory-based probabilistic amplification of coherent states

We analytically show that probabilistic amplification of a weak coherent state stored inside an atomic medium can be achieved via detection of coherently scattered photons. We show that this is because of collective excitations created among atoms in the ensemble. We describe the physics of the amplification and identify the failure events, which occur during the amplification process. The amplification is realized by coherently mapping a weak coherent state in an ensemble of $ \Lambda $Λ-level atoms followed by detection of multiple Raman scattered photons, conditionally projecting the coherent state into an amplified state upon retrieval.
Fast Slip Link Model for Bidisperse Linear Polymer Melts

A simple and fast slip link model called ecoSLM is presented and applied to mixtures of short and long linear polymers. It explicitly models binary entanglements between chains as slip links and offers a natural and powerful representation of constraint release. A multichain Markov chain Monte Carlo algorithm is developed to simulate stress relaxation following a step shear in the linear viscoelastic regime. The time required for accumulated slack to equilibrate along the chain contour is subsumed into the definition of the time step. The parameters of the ecoSLM are determined from data on monodisperse linears by mapping the time and modulus scales and specifying a parameter γ that is related to the variation of the zero-shear viscosity with molar mass. Predictions of viscosity and dynamic moduli obtained using the ecoSLM are in remarkably good agreement with experimental data on 1,4-polybutadienes. Thus, ecoSLM fills a valuable niche in describing the long and intermediate timescale dynamics of bidisper...
Cancer drugs approved for use in children: Impact of legislative initiatives and future opportunities

It is well appreciated that the number of anticancer drugs approved for use in children is a fraction of the number approved for use in cancers that occur in adults. We address this fact by summarizing the relevant U.S. legislation that provides the framework for the evaluation and approval of drugs used to treat children with cancer. In total, the Food and Drug Administration (FDA) has approved 38 new drug applications for pediatric oncology indications, 12 of which were new molecular entities. FDA continues to collaborate with multistakeholders regarding the development of products intended for pediatric cancer and encourages the submission of marketing applications.
E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation

Several post-translational modifications figure prominently in ventricular remodeling. The beta-O-linkage of N-acetylglucosamine (O-GlcNAc) to proteins has emerged as an important signal in the cardiovascular system. Although there are limited insights about the regulation of the biosynthetic pathway that gives rise to the O-GlcNAc post-translational modification, much remains to be elucidated regarding the enzymes, such as O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), which regulate the presence/absence of O-GlcNAcylation. Recently, we showed that the transcription factor, E2F1, could negatively regulate OGT and OGA expression in vitro. The present study sought to determine whether E2f1 deletion would improve post-infarct ventricular function by de-repressing expression of OGT and OGA. Male and female mice were subjected to non-reperfused myocardial infarction (MI) and followed for 1 or 4 week. MI significantly increased E2F1 expression. Deletion of E2f1 alone was not sufficient to alter OGT or OGA expression in a naive setting. Cardiac dysfunction was significantly attenuated at 1-week post-MI in E2f1-ablated mice. During chronic heart failure, E2f1 deletion also attenuated cardiac dysfunction. Despite the improvement in function, OGT and OGA expression was not normalized and protein O-GlcNAcyltion was not changed at 1-week post-MI. OGA expression was significantly upregulated at 4-week post-MI but overall protein O-GlcNAcylation was not changed. As an alternative explanation, we also performed guided transcriptional profiling of predicted targets of E2F1, which indicated potential differences in cardiac metabolism, angiogenesis, and apoptosis. E2f1 ablation increased heart size and preserved remote zone capillary density at 1-week post-MI. During chronic heart failure, cardiomyocytes in the remote zone of E2f1-deleted hearts were larger than wildtype. These data indicate that, overall, E2f1 exerts a deleterious effect on ventricular remodeling. Thus, E2f1 deletion improves ventricular remodeling with limited impact on enzymes regulating O-GlcNAcylation.
Demonstration and Modelling of Excellent RF Switch Performance of 22nm FD-SOI Technology for Millimeter-Wave Applications

A unique NFET device with specially treated region underneath the buried-oxide (BOX) in the state-of-the-art 22 nm FD-SOI technology (GLOBALFOUNDRIES’ 22FDX® technology), displays excellent switch performance for wide frequency range. Very gradual frequency response of the switch insertion-loss (IL) makes the device ideal choice for 80 GHz applications with sub-2 dB IL. Other RF figure of merits (FoMs) like cut-off frequency fT (351 GHz) and maximum oscillation frequency fMAX (317 GHz) along with the DC FoMs indicate that the device can be utilized for the power-amplifier (PA) and low-noise amplifier (LNA) applications also. For mmWave switch circuit designs, accurate modelling is important to predict the switch behaviour for wide frequency range. This paper proposes the modelling methodology to predict the unconventional frequency response of switch IL accurately up to 80 GHz.
Breakthrough Invasive Fungal Infections in Patients with Acute Myeloid Leukemia.

We sought to determine the occurrence, risk factors, effect of antifungal prophylaxis, and outcomes of invasive fungal infections (IFIs) in patients with acute myeloid leukemia (AML). We performed a retrospective analysis of all adult patients admitted to the University of Michigan Health System for AML over a 3-year period from 2010 to 2013. We determined comorbidities, hematopoietic cell transplant (HCT) status, antifungal prophylaxis, proven and probable IFI, and outcomes at 12 weeks after initiation of appropriate antifungal therapy. Of 333 patients in our cohort, 116 of whom had received a HCT, 98 (29%) developed an IFI. Of the 30 (9%) patients who had a proven or probable IFI, 18 had breakthrough infection while on micafungin (n = 5), voriconazole (n = 4), posaconazole (n = 5), or fluconazole (n = 4). Breakthrough IFIs were due to Aspergillus species (n = 11), other molds (n = 4), and Candida species (n = 3). Factors associated with breakthrough IFI were prolonged severe neutropenia (p = .05) and having received tacrolimus (p = .04). Antifungal therapy was successful in 7 of the 18 (39%) patients with breakthrough IFI and 8 of the 12 (67%) patients with non-breakthrough IFI, p = .13. Mortality at 12 weeks was 27%, 5 with breakthrough IFI and 3 with non-breakthrough IFI and was associated with prolonged severe neutropenia, p = .04. Patients with AML remain at risk for IFI despite the use of several different antifungal agents for prophylaxis. Mortality remains high in patients with AML who develop IFI.
A Resolução de Problemas para Licenciandos em Matemática: do Ensino Superior às Turmas de Educação Básica

In this article, a work proposal is presented, which sought to help future Mathematics teachers to think about classes based on the Teaching-Learning-Evaluation Methodology of Mathematics through Problem Solving (ALLEVATO; ONUCHIC, 2009; 2014; ONUCHIC, 1999; ONUCHIC; ALLEVATO, 2004; 2011). Such proposal emerges as a result of the practices and doctoral research of Zanon (2019). This researcher’s study was developed in 2019/1 with 40 students enrolled in the "Problem Solving" subject in the first semester of the Mathematics undergraduate course at the Instituto Federal do Espirito Santo (IFES), Campus Cachoeiro de Itapemirim. It is a qualitative investigation (FIORENTINI; LORENZATO, 2007) that understands the investigative activity as a power to the pedagogical practice of teachers in initial training. Thus, it proposes, through Problem Solving as a methodological perspective, possibilities for teaching Mathematics in undergraduate courses with a view to its applicability in the performance of Basic Education teachers. Basides that, this investigation uses the Activities Guidelines proposed by Onuchic and Allevato (2011) so that undergraduate students in Mathematics can appropriate ideas that allow them to use the Teaching-Learning-Assessment Methodology of Mathematics through Problem Solving in the classroom, when in teaching practice, as a way of translating the theoretical studies developed at the university into practice.
Attendance and Quality and Quantity of Research Presentations at an Obstetrics and Gynecology Regional Meeting Pre- and Postchanges in Federal Funding

INTRODUCTION Participating in scientific meetings offers value to physician trainees and faculty. In 2012, the U.S. Government (including the Department of Defense) instituted restrictions on conference travel, requiring central approval to attend. Hence, our objective was to determine the academic impact of research presented at the American College of Obstetricians and Gynecologists (ACOG) Armed Forces District Meeting and the effect of this federally mandated policy change on attendance and the quality and quantity of research. MATERIALS AND METHODS Attendance logs and meeting programs were reviewed for the 3 years immediately before and after institution of travel regulations. A PubMed search of each abstract was performed to determine if it resulted in publication and the mean duration in months from presentation to publication was calculated and compared between oral and poster presentations. The top journals accepting manuscripts were noted along with the corresponding impact factor. RESULTS The overall meeting publication rate was 22%. Oral presentations were significantly more likely than posters to achieve publication (P < 0.001). Following implementation of travel regulations, mean faculty attendance declined from 130 per year to 105 (P < 0.05). Declines in resident attendance and publication rates were not statistically significant. The top journals publishing investigations included Obstetrics and Gynecology (n = 15), Military Medicine (n = 12), and Fertility and Sterility and Gynecologic Oncology (tied, both n = 11). CONCLUSION Approximately one in five presentations at the ACOG Armed Forces District Meeting are published, many in high impact journals within the specialty. Implementation of stricter travel regulations adversely impacted faculty physician attendance, but not trainee participation or the publication rate.
Timely, Untimely, Timeless: Temporal Limits in J.M. Coetzee’s Late Global Fiction

J.M. Coetzee’s late global fictions regularly offer formal experiments with fleetingness – works designed to become dated, superannuated – yet repeatedly return to the theme of enduring, almost tra...
On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics

Contrary to frequent reports in the literature, hydroxyl radical is not a key species participating in endogenous oxidative DNA damage. Instead, carbonate radical anion is formed from the Fenton reaction under cellular conditions and from decomposition of nitrosoperoxycarbonate generated during inflammation. Carbonate radical anion is a potent one-electron oxidant capable of generating base radical cations that can migrate over long distances in duplex DNA, ultimately generating 8-oxo-7,8-dihydroguanine at a redox-sensitive sequence such as GGG. Such a mechanism enables G-quadruplex-forming sequences to act as long-range sensors of oxidative stress, impacting gene expression via the DNA repair mechanism that reads and ultimately erases the oxidized base. With a writing, reading and erasing mechanism in place, oxidative 'damage' to DNA might be relabeled as 'epigenetic' modifications.
The tradeoffs of using female suicide bombers

Why are there so few female suicide bombers despite their tactical effectiveness? To explain the rarity of this phenomenon, I examine the tradeoffs that armed groups face when using female suicide ...
Symposium in Amsterdam, Formation of CDA, Work of the Founders

The chapter begins by briefly discussing the general domain of discourse analysis (DA) (including text linguistics), van Dijk’s (1985) Handbook of Discourse Analysis, and an explanation of how DA set the stage for the development of CDA. We then describe the emergence of critical discourse analysis (CDA) following a small symposium in Amsterdam in January 1991 about DA and a ‘critical’ approach to DA—which eventually became CDA. We describe briefly the events leading up to the symposium and what was accomplished there followed by the consolidation and development of CDA. Next, we discuss the five scholars at the meeting, beginning with a short description of Gunther Kress’s work before he decided to pursue his interests in education. We then move to a discussion of the work of Norman Fairclough, van Dijk, and Ruth Wodak, which includes detailed descriptions of their most important contributions before 1991, their work in the 1990s, in general their relation to what is now CDS/CDA, the productive professional collaboration of van Dijk and Wodak, and a special focus on Wodak’s role as promoter, biographer and historian of how CDA developed and changed over the years. We complete the chapter with a look at van Leeuwen’s work in SocSem, multimodality, and CDA.
Tip of the Tongue: Reflections on Language and Meaning

Our contemporary world is filled with noise and stimulation. Easy access to video and audio entertainment has led to an enormous outpouring of human creativity, but in that lies a discomfiting sens...
Effective Fragment Potentials for Flexible Molecules: Transferability of Parameters and Amino Acid Database

An accurate but efficient description of noncovalent interactions is a key to predictive modeling of biological and materials systems. The effective fragment potential (EFP) is an ab initio-based force field that provides a physically meaningful decomposition of noncovalent interactions of a molecular system into Coulomb, polarization, dispersion, and exchange-repulsion components. An EFP simulation protocol consists of two steps, preparing parameters for molecular fragments by a series of ab initio calculations on each individual fragment, and calculation of interaction energy and properties of a total molecular system based on the prepared parameters. As the fragment parameters (distributed multipoles, polarizabilities, localized wave function, etc.) depend on a fragment geometry, straightforward application of the EFP method requires recomputing parameters of each fragment if its geometry changes, for example, during thermal fluctuations of a molecular system. Thus, recomputing fragment parameters can easily become both computational and human bottlenecks and lead to a loss of efficiency of a simulation protocol. An alternative approach, in which fragment parameters are adjusted to different fragment geometries, referred to as "flexible EFP", is explored here. The parameter adjustment is based on translations and rotations of local coordinate frames associated with fragment atoms. The protocol is validated on extensive benchmark of amino acid dimers extracted from molecular dynamics snapshots of a cryptochrome protein. A parameter database for standard amino acids is developed to automate flexible EFP simulations in proteins. To demonstrate applicability of flexible EFP in large-scale protein simulations, binding energies and vertical electron ionization and electron attachment energies of a lumiflavin chromophore of the cryptochrome protein are computed. The results obtained with flexible EFP are in a close agreement with the standard EFP procedure but provide a significant reduction in computational cost.
Fifteen Years of Aortic Valve-sparing Root Replacement and Impact of Eccentric Jets on Late Outcomes.

Abstract Background Valve-sparing root replacement is more challenging with eccentric aortic insufficiency due to cusp and root asymmetry, which may impact valve durability and survival. This study analyzed the effect of jet eccentricity on long-term outcomes in tricuspid aortic valves (TAVs) and bicuspid aortic valves (BAVs). Methods From 2005 to 2019, 111 patients (65 TAVs, 46 BAVs) with >2+ aortic insufficiency underwent valve-sparing root replacement at an academic center. Pre- and postoperative echocardiograms were analyzed. Of these, 32 patients presented with concentric jets (29 TAVs, 3 BAVs) and 71 with eccentric jets (28 TAVs, 43 BAVs). Median follow-up was 49 months (interquartile range, 12-93). Kaplan-Meier analysis and cumulative risk were used to compare long-term survival and valve-related reintervention. Results Mean patient age was 44 ± 12 years. Compared with TAV, more BAV patients presented with eccentric jets (93.5% vs 43.1%, P Conclusions In patients presenting for valve-sparing root replacement with >2+ aortic insufficiency the risk of valve-related reintervention long term was low after cusp repair in TAVs and BAVs. Current results suggest preoperative jet eccentricity does not impact long-term survival and valve durability.
Sigmoid colon obstruction due to Kaposiform Haemangioendothelioma

Abstract Background Kaposiform Haemangioendothelioma (KHE) is a very rare, benign but locally aggressive vascular tumour. Its incidence is 1/100000, and it is most commonly found in the cutaneous tissues of the extremities. Presentation A 6-month-old presented acutely after 2 days of increasing abdominal distension. Apart from distension, clinical examination was unremarkable. An abdominal x-ray demonstrated massive gaseous distension of bowel loops. A contrast enema demonstrated an irregular stenosis within the sigmoid colon. An urgent laparotomy was performed. Management A thick and very inflammatory stricture was resected. Histopathology confirmed this as Kaposiform Haemangioendothelioma with margin involvement. Patient had a complicated post-operative period due to prolonged sepsis resulting in a cardiac arrest and two return journeys to theatre. An MRI brain was performed after patient stabilisation, demonstrating bilateral cerebral infarcts – the patient went on to develop cerebral palsy. Discussion Mainstay management of KHE is primary resection. It is associated with Kasabach-Merritt Phenomenon – a consumptive coagulopathy, which is present in 70% of KHE patients and has an associated 10% mortality rate. Conclusion There are a small number of cases of KHE with gastrointestinal involvement in the literature. A number of these presented with bowel obstruction but no other had such a complicated post-operative course.