cssi/SciSciGPT-SciSciNet huggingface dataset:
The effect of prednisone on glycoprotein sulfate metabolism in normal men

Abstract Eight normal men were studied after intravenous injection of sodium 35SO4. Three of them were studied again while ingesting 40 mg./day of prednisone. Prednisone therapy depressed the specific activities of sulfated acid mucopolysaccharides (APS) which were excreted in the urine during the first day, but did not have demonstrable effect on the sulfated APS which had slower turnover rates. It also depressed the excretion of nondialyzable radioactivity during the first 24 hours following 35SO4 injection. It did not have demonstrable effect on the excretion of 24 hour urinary APS. Prednisone therapy was associated with depression of the specific activities of the perchloric acid insoluble (PAI) serum proteins at 1 hour and from 5 to 48 hours. It had no significant effect on the concentration of PAI, on the perchloric acid soluble (PAS) serum proteins, or on the specific activities of the PAS.
The field far from a charge and a dipole

Abstract We consider the field far from charged and dipolar impurities in a fluid of polarizable non-polar atoms. Comparison with a recent computer simulation shows that classical continuum ideas are adequate for a charge, but not for a non-polarizable dipole; we present a very simple theory which agrees well with the simulation in that case. No simulation exists for a polarizable dipole, which we also discuss.
A column generation approach for aircraft sequencing problems: a computational study

This paper investigates the computational tractability of aircraft sequencing problems over multiple runways under mixed mode operations, contrasting an enhanced mixed-integer programme (MIP) and an accelerated column generation approach. First, we examine the benefit of augmenting a base MIP with valid inequalities, preprocessing routines, and symmetry-defeating hierarchical constraints in order to improve the performance of branch-and-bound (B&B)/cut techniques as implemented in commercial solvers. Second, we alternatively reformulate the problem as a set partitioning model that prompts the development of a specialized column generation approach. The latter is accelerated by incorporating an interior point dual stabilization scheme and a complementary column generation routine. Empirical results using a set of new, computationally challenging instances and classical instances in the OR Library reveal the potential and limitations of the two methodologies.
Prognostic factors for patients with sarcomas of the pelvic bones

BACKGROUND Treatment of malignant tumors of the pelvis represents one of the most difficult problems in musculoskeletal oncology. However, factors that influence the local and systemic control of the disease remain ill-defined. METHODS One hundred and two patients with localized pelvic sarcomas who underwent a surgical excision of the tumors were analyzed. The tumor diagnosis was chondrosarcoma in 49 patients, osteosarcoma in 26 patients, Ewing's sarcoma in 20 patients, and other tumors in 7 patients. The tumor was located in the ilium in 65 patients, the pubis in 21 patients, the ischium in 8 patients, and the sacrum in 8 patients. Eighty-three patients underwent a limb-sparing surgery and 19 patients underwent hemipelvectomy. Prognostic factors for local recurrence, metastasis, and survival were analyzed. RESULTS At last follow-up, 47 patients were disease free, 7 were alive with disease, and 48 had died. The 5-year survival rate was 55% (chondrosarcoma: 65%, osteosarcoma: 47%, and Ewing's sarcoma: 52%). Inadequate surgical margin emerged as the only independent adverse prognostic factor for local recurrence. For distant metastasis, surgical stage remained as an independent prognostic factor. Patients who underwent a hemipelvectomy and those who had an inadequate surgical margin had significantly poorer survivals. CONCLUSIONS Pelvic sarcomas remain diseases with a poor prognosis. Independent prognostic factors are few; an adequate surgical margin is critical to prevent local recurrence, and the surgical stage is related to the risk of distant metastasis. Surgical margins and hemipelvectomy were predictors of survival, but the patients who underwent hemipelvectomy also tended to have the largest, most advanced tumors. Hemipelvectomy should be considered when there is sacral involvement. Cancer 1998;82:851-9. © 1998 American Cancer Society.
The Influence of the MJO on Upstream Precursors to African Easterly Waves

AbstractThe Madden–Julian oscillation (MJO) produces alternating periods of increased and reduced precipitation and African easterly wave (AEW) activity in West Africa. This study documents the influence of the MJO on the West African monsoon system during boreal summer using reanalysis and brightness temperature fields. MJO-related West African convective anomalies are likely induced by equatorial Kelvin and Rossby waves generated in the Indian Ocean and West Pacific by the MJO, which is consistent with previous studies. The initial modulation of tropical African convection occurs upstream of West Africa, near the entrance of the African easterly jet (AEJ). Previous studies have hypothesized that an area to the east of Lake Chad is an initiation region for AEWs. Called the “trigger region” in this study, this area exhibits significant intraseasonal convection and wave activity anomalies prior to the wet and dry MJO phases in the West African monsoon region.In the trigger region, cold tropospheric tempera...
Maintenance Chemotherapy for Advanced Non-Small-Cell Lung Cancer: New Life for an Old Idea

Although well established for the treatment of certain hematologic malignancies, maintenance therapy has only recently become a treatment paradigm for advanced non-small-cell lung cancer. Maintenance therapy, which is designed to prolong a clinically favorable state after completion of a predefined number of induction chemotherapy cycles, has two principal paradigms. Continuation maintenance therapy entails the ongoing administration of a component of the initial chemotherapy regimen, generally the nonplatinum cytotoxic drug or a molecular targeted agent. With switch maintenance (also known as sequential therapy), a new and potentially non-cross-resistant agent is introduced immediately on completion of first-line chemotherapy. Potential rationales for maintenance therapy include increased exposure to effective therapies, decreasing chemotherapy resistance, optimizing efficacy of chemotherapeutic agents, antiangiogenic effects, and altering antitumor immunity. To date, switch maintenance therapy strategies with pemetrexed and erlotinib have demonstrated improved overall survival, resulting in US Food and Drug Administration approval for this indication. Recently, continuation maintenance with pemetrexed was found to prolong overall survival as well. Factors predicting benefit from maintenance chemotherapy include the degree of response to first-line therapy, performance status, the likelihood of receiving further therapy at the time of progression, and tumor histology and molecular characteristics. Several aspects of maintenance therapy have raised considerable debate in the thoracic oncology community, including clinical trial end points, the prevalence of second-line chemotherapy administration, the role of treatment-free intervals, quality of life, economic considerations, and whether progression-free survival is a worthy therapeutic goal in this disease setting.
CD10 expression in peripheral T-cell lymphomas complicated by a proliferation of large B-cells.

CD10 expression by the neoplastic T cells in angioimmunoblastic T-cell lymphoma was recently described. As cases of peripheral T-cell lymphoma, unspecified, fail to show similar CD10 expression, this feature helps discriminate between these two entities, particularly in cases exhibiting morphologic overlap. Given these findings, we studied CD10 expression in a subtype of peripheral T-cell lymphoma known as peripheral T-cell lymphoma complicated by a proliferation of large B cells and compared it with angioimmunoblastic T-cell lymphoma and angioimmunoblastic T-cell lymphoma with a large B-cell proliferation. A total of 33 cases were identified including peripheral T-cell lymphoma complicated by a proliferation of large B cells (10), angioimmunoblastic T-cell lymphoma (10) and angioimmunoblastic T-cell lymphoma with a large B-cell proliferation (13). Diagnoses were established by hematoxylin and eosin (H&E) stain, immunohistochemistry and/or molecular findings (polymerase chain reaction for T-cell receptor-gamma gene rearrangement). Two of 10 cases of peripheral T-cell lymphoma complicated by a proliferation of large B cells showed aberrant CD10 expression (20%) compared to 9/10 cases of angioimmunoblastic T-cell lymphoma (90%) and 8/13 of angioimmunoblastic T-cell lymphoma with a large B-cell proliferation (62%). One case each of angioimmunoblastic T-cell lymphoma and angioimmunoblastic T-cell lymphoma with a large B-cell proliferation showed a rare, but not unequivocal, CD10(+) atypical cell. Four cases of angioimmunoblastic T-cell lymphoma with a large B-cell proliferation were CD10 negative. Of the 2 CD10(+) peripheral T-cell lymphoma complicated by a proliferation of large B cells, one had no H&E or IHC features of angioimmunoblastic T-cell lymphoma and showed only a rare positive cell. The second case, a lung biopsy, exhibited diffuse CD10 tumor cell positivity. The predominant staining pattern in the CD10(+) cases was characterized by scattered, mostly individual, morphologically neoplastic cells. A rare case showed clusters of positive cells. Our data indicate that only 20% of cases of peripheral T-cell lymphoma complicated by a proliferation of large B cells show CD10 expression by the neoplastic T cells in contrast to angioimmunoblastic T-cell lymphoma and angioimmunoblastic T-cell lymphoma with a large B-cell proliferation which exhibit CD10 staining in 90 and 62% of cases, respectively. This finding does not reach statistical significance with a P-value of 0.57 (Fisher's exact test). As these entities appear to be biologically distinct and may portend different overall survivals, CD10 expression may serve as an additional discriminating criterion.
Evaluation of Fiber Content Relative to Other Measures of Compost Stability

Improved methods for assessing compost stability are needed. We collected thirteen separate compost samples from a single windrow over a 91 d period. Initial assessment of compost stability used standard analyses, including total C and N concentration, C:N ratio, and inorganic N concentration. Compost C and N lability were assessed by measuring CO2 evolution during a 24 hr period, and also using a commercially available compost evaluation kit which includes both CO2 and NH3 release to establish a Maturity Index. We also estimated slowly degradable C fractions in the composts using neutral detergent fiber (NDF) and lignin methods developed for ruminant feed analysis. The relationship between stability and each compost constituent was evaluated using simple linear regression. Some widely-used parameters, like compost C:N ratio, changed very little during compost aging. Compost CO evolution showed a strong linear relationship with the compost age, with a coefficient of determination (r2) of 0.82. Likewise, f...
Evaluation of the Shortcomings of Current Engine Technology Stack-Up Methods and Suggestions for Improvement

There are currently numerous government and industry entities engaging in aviation technology development programs [1,2,3]. Due to the number of technologies being investigated there exists an understandable desire to rank technologies in order to identify the most beneficial ones. Historically, this has been done through the use of “waterfall” or technology stack-up charts [4].One purpose of such waterfall charts is to show the amount of benefit each technology provides to the integrated system. This approach is valid, and extremely useful, for verifying the modeling of such technologies; however, there are shortcomings in using a waterfall chart to assess the relative contribution of individual technologies to the overall system level benefit. This is due to several considerations that are not taken into account when developing conventional technology ranking charts. For example, the relative impact of each technology can be highly dependent on the order in which technologies are applied, the system the technology is applied to, the relative design changes that occur either before or after the technology is applied, and other technologies that are present on the system. In order to explore these characteristics this paper uses propulsion technologies since there are strong interactions between the various components of an engine. Engine technologies also commonly rely upon enabling technologies which provide less benefit, but without them the larger “bigger hitting” technologies are not feasible.This research explores and quantifies the issues associated with several conventional methods of creating technology ranking charts. Propulsion technologies targeting both thermal and propulsive efficiency are applied to a baseline aircraft and engine configuration. Several conventional technology ranking and stack-up techniques are applied in order to evaluate how the relative impacts of individual technologies vary greatly depending on the assessment method. In all cases the same technology packages are applied such that the final benefit is the same, regardless of ranking method. It is suggested that a range of currently used ranking techniques all used to determine a more robust estimate of the impact.Copyright © 2013 by ASME
An Exploration of DSM-Oriented Scales in the Prediction of Criminal Offending Among Urban American Youths

Research has long suggested comorbidity between mental health and poor life course outcomes such as delinquency. The early identification of mental illness in youths is an important goal for researchers examining the relationship between mental disorder and offending. The present study examined the comorbidity of various mental health problems such as anxiety, affective, attention deficit/hyperactivity, somatic, and oppositional defiant problems and their effect on offending in youths participating in the Project on Human Development in Chicago Neighborhoods (PHDCN). Innovative Diagnostic and Statistical Manual (DSM)—oriented scales that allow for distinctions between normal, borderline, and clinical levels of mental health problems were used in logistic regressions to predict the odds of offending across four stages of development. Findings showed a consistent pattern across the life course of oppositional defiant problems increasing the likelihood of future property and violent offending. Furthermore, the value of using DSM-oriented scales was demonstrated. Implications for future studies and policy are discussed.
Optimality of qubit purification protocols in the presence of imperfections

Quantum control is an essential tool for the operation of quantum technologies such as quantum computers, simulators, and sensors. Although there are sophisticated theoretical tools for developing quantum control protocols, formulating optimal protocols while incorporating experimental conditions remains a challenge. In this paper, motivated by recent advances in realization of real-time feedback control in circuit quantum electrodynamics systems, we study the effect of experimental imperfections on the optimality of qubit purification protocols. Specifically, we find that the optimal control solutions in the presence of detector inefficiency and non-negligible decoherence can be significantly different from the known solutions to idealized dynamical models. In addition, we present a simplified form of the verification theorem to examine the global optimality of a control protocol.
Global model for high power microwave breakdown at high pressure in air

Global models (GM) have proven a key tool for modeling low temperature plasmas for materials processing due to simplicity and speed. However, a GM requires specification of the electron energy distribution function (EEDF). The assumption of a Maxwellian EEDF leads to inaccurate power absorption and reaction rate coefficients and results in errors in plasma parameter prediction in high power microwave (HPM) driven discharges. In this work, a GM was developed with a pressure-independent enhanced EEDF and enhanced power absorption model to improve fidelity for modeling HPM breakdown, and extended to two decades in applied frequency. The GM is applied to HPM breakdown in air at high pressure and over a wide frequency range, and results compared well with PIC-MCC simulations as well as experimental data.
Increased Ribonucleic Acid Polymerase Activity Associated with Chromatin from Internodes of Dwarf Pea Plants Treated with Gibberellic Acid

Gibberellic acid increases the level of RNA polymerase associated with chromatin isolated from expanding internodes of light-grown, dwarf pea plants (Pisum sativum L.), without a detectable increase in the amount of DNA template available.
Palaeoecology of a primate-friendly, middle Eocene community from Laredo, Texas and a review of stratigraphic occurrences of Paleogene land mammals across the Gulf Coastal Plain, USA

Recent analysis of primate remains in the Casa Blanca local fauna from the late middle Eocene Laredo Formation at Laredo, Texas has shown that the fauna’s primate species diversity was greater than previously reported. Recognition of Mahgarita cf. M. stevensi provided the first record of an Old World cercomoniine species in a Uintan community in North America. The presence of three omomyids indicates that primate species diversity in the paralic Casa Blanca community was similar to that in late Uintan age faunas in both Trans-Pecos, Texas and in the Uinta Basin of Utah. Palaeoecologic evidence from associated plant, invertebrate and vertebrate remains indicates that the regional community setting was a tropical mangrove swamp fringing a lowland coastal rain forest. This late middle Eocene climate was probably similar to the early middle Eocene climate which prevailed in Germany at the time the Messel community inhabited the region. A review of stratigraphic occurrences of Paleogene land mammal remains across the Gulf Coastal Plain indicates that the Casa Blanca fauna is one of only two Paleogene land mammal communities known from Gulf Coastal deposits. These coastal land mammal occurrences provide rare opportunities to correlate Paleogene land mammal communities known from the interior of North America with strata bearing marine species.
Consistent Estimation of Censored Demand Systems Using Panel Data

We derive a joint continuous/censored commodity demand system for panel data applications. Unobserved heterogeneity is controlled for using a correlated random effects specification and a generalized method of moments framework used to estimate the model. While relatively small differences in elasticity estimates are found between a flexible random effects specification and one that restricts the random effect coefficient to be time invariant, larger differences are observed when comparing the flexible model to a pooled cross-sectional estimator. The results suggest the limited ability of such estimators to control for preference heterogeneity and unit-value endogeneity leads to parameter bias.
Analysis of gender differences in early perioperative complications following radical cystectomy at a tertiary cancer center using a standardized reporting methodology

Abstract Objectives Gender differences in perioperative complications following radical cystectomy (RC) are under-studied, but suggest a tendency for higher blood loss and/or transfusion in females. Variability in reporting methodologies may affect findings; therefore, we utilized a standardized reporting methodology to evaluate for gender differences in perioperative complications at a tertiary cancer center. Materials and methods A retrospective review of the Memorial Sloan-Kettering Cancer Center (MSKCC) RC database between 1995 and 2005 was performed. All complications within 90 days of surgery were recorded and classified using a 5-grade modification of the Clavien system. Results Of 1,142 study patients, 280 (25%) were female. Preoperatively, females were more likely to have multiple co-morbidities (39% vs. 27%, P 4 units red blood cells: 13% vs. 8%; P = 0.025). Although females were significantly more likely than males to experience a complication within 90 days of surgery (72% vs. 62%; P = 0.003); we did not find any important differences in the rate, grade, type, or timing of complications between genders. Additionally, females were less likely than males to receive a continent diversion (25% vs. 40%, P Conclusions Females in our cohort had significantly higher blood loss, more transfusions, and a higher rate of complications. Females were also less likely to undergo a node dissection or continent diversion, for reasons not totally attributable to patient or disease characteristics, implying patient or surgeon preference played a role.
Nucleus-associated RNA in measles virus-infected cells

Abstract Measles virus RNA was found in the nuclear fraction of infected Vero cells. 24-hr labeling periods revealed heterogeneously sedimenting 15–50 S RNA associated with a membrane-containing particulate. Viral RNA isolated after shorter labeling periods was larger in size (30–50 S) and associated with both nucleoplasmic and particulate fractions.
Governance Matters: Why Nations Succeed

Historians at one time emphasized the critical causal interventions of important individuals, ascribing decisive differences in outcomes across time and place to human agency and idiosyncratic initiative. Subsequently, structure, contingency, and a collection of nonidiosyncratic choices became more prominent in causal explanations. Culture, geography, climate, economic circumstance, ideology, etc., became the favored variables in attempts to answer significant questions about key turning points in the global past. In Why Nations Fail, however, Acemoglu and Robinson demonstrate that leadership and governance matter much more than we thought. Although structural analyses add powerfully to our research, it is the quality of leadership that often determines whether a state is to flourish politically or economically.
Human parvovirus B19-induced vesiculopustular skin eruption

Erythema infectiosum, fifth disease, is a usually benign macular or maculopapular exanthem of childhood caused by the human parvovirus B19. A 27-year-old woman with a serologically documented human parvovirus infection who presented with a hemorrhagic exanthem and enanthem with areas of pustules and pseudo-pustules is described. The histologic findings were unusual because they combined the histologic features of morbilliform and vesiculopustular viral lesions. This case serves to underscore the occurrence of human parvovirus infection in adults. Further, it demonstrates the need to include parvovirus infection in the differential diagnosis of virally induced vesiculopustular skin eruptions.
Recent Advances in the Design and Development of Novel Negative Allosteric Modulators of mGlu5

Negative allosteric modulators (NAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) have remained attractive to researchers as potential therapies for a number of central nervous system related diseases, including anxiety, pain, gastresophageal reflux disease (GERD), addiction, Parkinson’s disease (PD), and fragile X syndrome (FXS). In addition to the many publications with supportive preclinical data with key tool molecules, recent positive reports from the clinic have bolstered the confidence in this approach. During the 2 year time span from 2009 through 2010, a number of new mGlu5 NAM chemotypes have been disclosed and discussed in the primary and patent literature. A summary of several efforts representing many diverse chemotypes are presented here, along with a discussion of representative structure–activity relationships (SAR) and synthetic approaches to the templates where possible.
A Loosely Coupled Planar Wireless Power Transfer System Supporting Multiple Receivers

A high-efficiency wireless power transfer system which is capable of supporting more than one receiver using class E operation for transmitter via inductive coupling has been designed and fabricated. The design approach of the system is also presented in this paper. The system requires no complex external control system but relies on its natural impedance response to achieve the desired power delivery profile across a wide range of load resistances while maintaining high efficiency to prevent any heating issues. A switch circuit is used to decouple the fully charged receiver from the system so that power delivery to the other receiver can be improved. The fabricated system at 12 V supply voltage is compact and capable of approximately 2.5 W of power delivery to each of the two receivers in a dual receiver setup and 5 W to a single receiver alone or when the other receiver is decoupled by the receiver switch. During high-power delivery state, the system efficiency is between 67.5% and 77.5%.
Metabolic changes in excised fruit tissue-I. Factors affecting the development of a malate decarboxylation system during the ageing of disks of pre-climacteric apples

Abstract A system develops in peel from preclimacteric apples during ageing for periods up to 48 hr which rapidly decarboxylates added malate (the malate effect). This development is preceded by a peak of incorporation of 14C-valine into the protein of the tissue. During the period of increased 14C-valine incorporation the tissue develops the capacity to produce ethylene, and exogenous ethylene reduces the time taken to reach the full malate effect. Cycloheximide and other inhibitors of protein synthesis prevent the incorporation of 14C-valine and the development of the malate effect. Changes in uptake of the various substrates do not appear to be involved in these phenomena. It is suggested that ethylene, RNA and protein synthesis are all involved in the development of the malate effect.
Dentognathic remains of an afropithecus individual from kalodirr, kenya

We describe here the well-preserved dentognathic remains of an Afropithecus individual from the early Miocene site of Kalodirr in northern Kenya. The specimen includes a nearly complete dentition in which most of the crowns are undamaged and unworn. The new information gleaned from this specimen adds to our knowledge of this genus in several ways. Afropithecus exhibits an atypical pattern of canine dimorphism, and is probably more easily sexed by the pattern of variation in its upper premolars. Both phenomena are likely related to the modification of its antemolar dentition for the purpose of sclerocarp harvesting. The new fossils clarify the role in this adaptation of the premolars, which appear specialized for initiating and propagating cracks in large food items bearing protective coats. Comparison with other Miocene apes suggests that the closest known relative of Afropithecus is Nacholapithecus, to which Equatorius is more distantly related. Morotopithecus shares some primitive traits with Afropithecus, but lacks the derived features shared by the latter and Nacholapithecus.
Contributions of language and memory demands to verbal memory performance in language-learning disabilities.

Abstract The purpose of this study is to investigate the performance of adults with language-based learning disorders (L/LD) and normal language controls on verbal short-term and verbal working memory tasks. Eighteen adults with L/LD and 18 normal language controls were compared on verbal short-term memory and verbal working memory tasks under low, moderate, and high linguistic processing loads. Results indicate no significant group differences on all verbal short-term memory tasks and verbal working memory tasks with low and moderate language loads. Statistically significant group differences were found on the most taxing condition, the verbal working memory task involving high language processing load. The L/LD group performed significantly worse than the control group on both the processing and storage components of this task. These results support the limited capacity hypothesis for adults with L/LD. Rather than presenting with a uniform impairment in verbal memory, they exhibit verbal memory deficits only when their capacity limitations are exceeded under relatively high combined memory and language processing demands. Educational Objectives: The reader will (1) understand the relationship between increased linguistic demands and working memory, and (2) learn about working memory skills in adults with language learning disorders.
Long-lasting morphological changes in dendritic spines of dentate granular cells following stimulation of the entorhinal area.

Stimulation of the perforant path induces a long-lasting increase in the area of dendritic spines, which are sites of termination of the stimulated pathway in the distal third of the dentate molecular layer. No enlarged spines were found in the proximal third of the dentate molecular layer, where the commissural afferents terminate. Following a single tetanic stimulus of 30 sec duration at 30/sec, spines became significantly larger by 15%, 38%, 35% and 23% within poststimulation intervals of 2–6 min, 10–60 min, 4–8 h, and 23 h, respectively. Axon terminals decreased their area by 15% within the 2–6 min interval and the vesicle density was decreased by 19% within the 10–60 min interval. Both changes were reversible and terminals resumed their prestimulation condition at longer intervals (>4 h). The initial enlargement of spines was interpreted as being due to a glutamate-induced increase in the sodium permeability of the spine membrane, whereas for the long-lasting enlargement an increase in protein synthesis was postulated. The long-lasting enlargement of dendritic spines in the dentate molecular layer following a short train of stimuli delivered to the perforant path, supports the postulate which links such a change to the mechanism of long-lasting postactivation potentiation observed in this pathway.
Pathophysiology of Target-Organ Disease: Does Angiotensin II Remain the Key?

Basic research provides an increasingly compelling rationale for renin-angiotensin system (RAS) blockade in hypertension treatment and cardiovascular risk reduction. Clinical trials addressing blood pressure-independent effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers, however, have yielded mixed results, in part because of incomplete RAS blockade. Animal studies have shed new light on the complexity of RAS pathways involved in the induction of target-organ damage. New outcomes trials are under way to explore the full potential of more complete RAS blockade with regard to cardiovascular target-organ protection.
White bass population demographics in a northwestern South Dakota reservoir

The white bass (Morone chrysops) is an important sport fish species in the upper Midwest. As such, understanding white bass dynamics is critical for managing its populations. Thus, we evaluated population dynamics of white bass in a northwestern South Dakota reservoir and attempted to determine whether bass recruitment patterns were more related to reservoir inflows or spring weather patterns. We found that white bass growth increased from 243 mm for age-2 fish, to 322 mm for age-6 fish, and then to 346 mm at age 9. The total annual mortality rate was 29.7%. In terms of year-class strength, white bass recruitment was erratic. The recruitment pattern was more related to spring weather patterns than reservoir inflow. In comparison, white bass population dynamics in this South Dakota irrigation reservoir were more similar to those of white bass populations in Midwestern glacial lakes than those found in southern US reservoirs.
The role of high-dose methotrexate with citrovorum factor "rescue" in the treatment of osteogenic sarcoma.

Abstract Osteogenic sarcoma has been shown to be responsive to adriamycin (ADR) and vincristine-high-dose methotrexate with citrovorum factor "rescue" (VCR-MTX-CF). Both regimens have produced responses in patients with established disease. These experiences prompted utilization of these forms of chemotherapy in adjuvant programs. The VCR-MTX-CF regimen was also utilized in combination with radiation therapy to treat patients with inoperable tumors and those with presumed residual microscopic tumor in the lungs or elsewhere following surgical resection. More recently, chemotherapy was utilized in pre-treatment programs to facilitate local en bloc resection and insertion of internal prostheses to achieve useful functioning limbs. The evolution of these programs at the Sidney Farber Cancer Institute from January 1971, is documented and the results are updated to June 1976.
Signal transduction in exopolysaccharide alginate synthesis: phosphorylation of the response regulator AlgR1 in Pseudomonas aeruginosa and Escherichia coli.

Abstract Synthesis of alginate by Pseudomonas aeruginosa correlates with its pathogenicity in the lungs of patients suffering from cystic fibrosis (CF). Alginate synthesis-encoding genes (alg) in P. aeruginosa are normally silent, but are specifically triggered in the CF lung environment. The promoter for the algD gene, located at the upstream end of the alg cluster, is activated by environmental factors such as high osmolarity, nutrient limitation and dehydration. Several regulatory proteins are known to control transcription from the algD promoter. Among these proteins is AlgR1 which is homologous to the phosphorylation-dependent response regulators of the two-component signal transduction system. In this paper, we report that AlgR2, an 18-kDa protein which in cooperation with AlgR1 regulates the algD promoter, undergoes phosphorylation in the presence of ATP. The phosphate group acquired by AlgR2 is then tranferred to AlgR1. In addition, we show that AlgR1 can be phosphorylated by an AlgR2-analog in Escherichia coli. AlgR1 is isolated in a phosphorylatable 80-kDa complex in association with AlgR2 in P. aeruginosa and the AlgR2-analog in E. coli.
Synthesis of α-trifluoromethylated indoleacetic acid: a potential peroxidase-stable plant growth regulator

Abstract A novel trifluoromethylated indoleacetic acid analog was synthesized by condensation of indole with methyl trifluoropyruvate, and the subsequent reduction. The presence of a trifluoromethyl group at the α-position protected this indoleacetic acid from the oxidation of horseradish peroxidase.
On the analytic inversion of functions, solution of transcendental equations and infinite self-mappings

The solution of seemingly simple transcendental equations is in effect equivalent to the general problem of analytical inversion of functions. Within a powerful and systematic method, based on the solution of an associated Riemann–Hilbert boundary value problem, beautiful explicit results for various inverse functions of physical importance have been found which inevitably take on the guise of integral representations of these functions. In an attempt to reduce one such solution to a standard-function expression which would then be easy to evaluate, we recognize an infinite ladder self-mapping solution. This new perspective, born out of complicated complex analysis, is straightforwardly and uniquely related to the systematic generation of fast converging expansions within the corresponding regions of single-valuedness of the inverse function.
Disease, Desire, and the Body in Victorian Women's Popular Novels

Introduction: why transgression, why now?: physical integrity in the electronic age 1. 'In the body of the text': metaphors of reading and the body 2. Genre: the social construction of sensation 3. M. E. Braddon: sensational realism 4. Rhoda Broughton: anything but love 5. Ouida: romantic exchange Afterword: the other Victorians Bibliography.
Update from CDC's Public Health Surveillance & Informatics Program Office (PHSIPO)

The growing automation of healthcare information affects surveillance systems that depend on information arising from healthcare use. Changing communications technologies and styles affect population health surveys. CDC's Public Health Surveillance & Informatics Program Office (PHSIPO) manages the National Notifiable Diseases Surveillance System, BioSense 2.0, and the Behavioral Risk Factor Surveillance System (BRFSS) and serves as the 'home' at CDC for addressing cross-cutting issues in surveillance and informatics practice. This panel will discuss how PHSIPO is supporting health departments in adapting to the changing public health landscape and will provide opportunities to hear from audience members.
Centralizers and character degrees

Let the finite solvable group A be acting on a finite group G and suppose that (|A|,|G|) = 1. The Glauberman correspondence provides a natural one-to-one correspondence between the irreducible characters of G invariant under A and all the irreducible characters of C G (A). Let cd(C G (A)) denote the set of degrees of the irreducible characters of C G (A) and let cd A (G) denote the set of degrees of the A-invariant irreducible characters of G. We prove that for every pair of positive integers (n, m), if m > 1, then there exists A and G as above such that $|{\rm cd}({\rm C}_G(A))| = n$ and $ |{\rm cd}_A(G)| = m$ .
Acute hemodynamic effects of pindolol and propranolol in patients with dilated cardiomyopathy: Relevance of intrinsic sympathomimetic activity

Abstract The administration of beta-blocking agents to patients with poor left ventricular (LV) function may result in clinical and hemodynamic deterioration. The beta antagonist pindolol has intrinsic sympathomimetic activity (ISA) and therefore may be better tolerated. To test this hypothesis 30 patients with a precatheterization diagnosis of dilated cardiomyopathy were randomly assigned to three groups to receive intravenous injections of placebo, propranolol, or pindolol. The baseline jection fraction and hemodynamics were similar for all groups. For propranolol 1 mg, 2 mg, 3 mg, and 4 mg doses were given 5 minutes apart until a maximum dose of 10 mg was reached, until a 25% reduction in the heart rate or mean arterial pressure occurred, or until clinical deterioration developed. For pindolol 0.1 mg, 0.2 mg, 0.3 mg, and 0.4 mg boluses were used with the same end points. Baseline hemodynamics were measured and repeated 15 minutes after the last dose of each drug was administered. The mean number of doses given was similar for both groups: 3.3 doses for the propranolol group and 3.4 for the pindolol group. Compared to propranolol, pindolol caused less of a reduction in heart rate, cardiac output. cardiac index, stroke volume index, and stroke work index and less of an increase in the mean right atrial pressure, mean pulmonary arterial pressure, mean pulmonary capillary wedge pressure, left ventriculs end-diastolic pressure, and pulmonary vascular resistance; there was a decrease in systemic vascular resistance. These differences were statistically significant for changes in heart rate, right atrial pressure, cardiac index, and systemic vascular resistance. Although no patients in the pindolol-treated group had clinical deterioration, four in the propranolol-treated group required tomporary intravenous inotropic support. Based on these data we conclude that pindolol as compared to propranolol is better tolerated acutely when given to patients with markedly reduced LV function. It is likely that the ISA of pindolol accounts for this effect. Therefore patients with severely reduced LV function who require beta blockade acutely may better tolerate pindolol or other beta-blocking agents that possess ISA than those that do not. Whether or not these same findings can be extrapolated to the chronic administration of beta blockade in patients with reduced LV function remains unknown and will require further investigation.
Adult immunizations: updates and practical guidance for the practicing allergist-immunologist

Instructions Credit can now be obtained, free for a limited time, by reading the review article in this issue and completing all activity components. Please note the instructions listed below: ● Review the target audience, learning objectives and all disclosures. ● Complete the pre-test online at http://www.annallergy.org (click on the CME heading). ● Follow the online instructions to read the full version of the article; reflect on all content as to how it may be applicable to your practice. ● Complete the post-test/evaluation and claim credit earned; at this time, youwill have earned up to 1.0 AMA PRA Category 1 Credit. Please note that the minimum passing score on the post-test is 70%. Release Date: November 1, 2012 Expiration Date: October 31, 2014 Estimated Time to Complete: 60 minutes Target Audience: Physicians involved in providing patient care in the field of allergy/asthma/immunology. Learning Objectives: At the conclusion of this activity, participants should be able to: ● Summarize new information on adult immunization and apply in practice, as appropriate. ● Discuss updated adult vaccine recommendations, rationale supporting these recommendations, and methods to maintain currency. Accreditation: The American College of Allergy, Asthma & Immunology (ACAAI) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Designation: The American College of Allergy, Asthma & Immunology (ACAAI) designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Planning Committee Members: Jeremy M. Sikora, MD (Senior Author) Michael S. Tankersley, MD (Author) Gailen D. Marshall, Jr, MD, PhD (Editor-in-Chief) Disclosure of Relevant Financial Relationships: J.M. Sikora, M.S. Tankersley and G.D. Marshall have nothing to disclose. Reviewers and Education/Editorial staff have no relevant financial relationships to disclose. No unapproved/investigative use of a product/device is discussed. Recognition of Commercial Support: This activity has not received external commercial support. Copyright Statement: 2012-2014 ACAAI. All rights reserved. mmu
Surface catalyzed electron transfer from polycyclic aromatic hydrocarbons (PAH) to methyl viologen dication: evidence for ground-state charge transfer complex formation on silica gel

Abstract Porous silica surfaces are shown to slowly catalyze the oxidation of adsorbed polycyclic aromatic hydrocarbons (PAH) to the corresponding radical cation via Lewis acid sites present on the surface. When a good electron acceptor such as methyl viologen dication (MV ++ ) is co-adsorbed on silica surface, a red-shifted structureless absorption band characteristic of a ground-state charge transfer (CT) complex formed between the PAH and MV ++ is observed. Oxygen efficiently competes with MV ++ for the trapped electrons on the active sites of silica surface causing a significant decrease in the concentration of ground-state CT complex. The rate of this electron transfer process is enhanced dramatically at the solid/liquid interface when solution of PAH in a non-polar solvent is added to dry silica containing adsorbed MV ++ . Room temperature electron paramagnetic resonance (EPR) spectra of PAHs adsorbed on silica show a broad unresolved signal ( g =2.0031–2.0045) due to PAH ⋅+ radical cation which disappears in the presence of air but can be restored upon evacuation of the sample. The EPR measurements of mixed samples containing PAH and MV ++ co-adsorbed on silica show a composite signal with hyperfine structure that may be due to presence of two paramagnetic species corresponding to MV ⋅+ and possibly PAH radical cation.
Computationally efficient neural predictive control based on a feedforward architecture

A new strategy for integrating system identification and predictive control is proposed. A novel feedforward neural-network architecture is developed to model the system. The network structure is designed so that the nonlinearity can be mapped onto a linear time-varying term. The linear time-varying model is augmented with a Kalman filter to provide disturbance rejection and compensation for model uncertainty. The structure of the model developed lends itself naturally to a neural predictive control formulation. The computational requirements of this strategy are significantly lower than those using the nonlinear neural network, with comparable control performance, as illustrated on a challenging nonlinear chemical reactor and a multivariable process, each with both nonminimum and minimum phase behavior.
Changing state in the plaid language

Plaid is a language in which objects are defined not by fixed classes, but by changing abstract states. We will overview he Plaid programming language through a series of examples drawing from domains like I/O code and web applications. Attendees will write Plaid code and experience its benefits.
Riverine dunes on the Coastal Plain of Georgia, USA

Abstract Relict eolian dunes on the Georgia Coastal Plain line the north and east sides of many SE-trending streams and contain important paleoenvironmental information. A detailed analysis of four dune fields characterizes dune geomorphology, stratigraphy, sedimentology and soils. Georgia's inland dunes range from parabolic to infilled parabolic to irregular in form, typically merge to form long chains that parallel source streams and can occur as distinct bands. Typically, the dunes are composed of >95% quartz sand grains, with more than half the sand falling in the medium sand fraction. Dunes overlie flood plain and pointbar sands, backswamp and peat deposits, fluvial terraces and other dunes. In places, organic deposits occur on top of dunes. Cross-bedding is observable in dunes more than about 4 m thick and indicates eastward dune migration. Paleosols found within some dunes indicate Holocene reworking. Conditions favoring dune formation likely included at least seasonal aridity. Postdepositional modification of the dunes includes a smoothing of the dune surface, a clay increase in the C horizon, spodic horizon development, bioturbation, removal of weatherable minerals and fluvial incision.
Random access parameter control for reliable u-healthcare services with highly loaded BAN traffic

Recent advance in sensor technology has introduced its useful applications to medical body area network MBAN. MBAN is considered as a cost-effective way to provide ubiquitous healthcare u-healthcare delivery service for the elderly people. This new type of service is expected to greatly improve the quality of their living. However, it is necessary to design a reliable access method in order to provide so-called ubiquitous services. To provide u-healthcare services, the sensor traffic gathered at a body central unit should be reliably delivered to the 'cloud' or the destination/service centre in time. We consider a cellular network as a medium for the traffic to reach the cloud. The current specifications for cellular systems provide prioritised access privilege for emergency call initiation ECI requests. However, if the ECI requests are overloaded, they cannot be effectively handled by the current method because they are all in the highest priority. We propose a simple and efficient method to handle this problem. Performance is evaluated and compared with the method specified in 3rd generation partnership project release 8. The proposed method is very useful for accommodating a number of BANs in a cellular network, especially when the number of active individual BAN users is densely populated and thus BAN traffic is highly loaded.