cssi/SciSciGPT-SciSciNet huggingface dataset:
Patient Vertical Centering and Correlation with Radiation Output in Adult Abdominopelvic CT

The purpose of this study was to determine if there is a significant effect, independent of patient size, of patient vertical centering on the current-modulated CT scanner radiation output in adult abdominopelvic CT. A phantom was used to evaluate calculation of vertical positioning and effective diameter at five different table heights. In addition, 656 consecutive contrast-enhanced abdominopelvic scans using the same protocol and automatic tube current modulation settings on a Philips Brilliance 64 MDCT scanner were retrospectively evaluated. The vertical position of the patient center of mass and the average effective diameter of the scanned patient were computed using the reconstructed images. The average volume CT dose index (CTDIvol) for each scan was recorded. The mean patient center of mass y coordinate ranged from -3.7 to 6.7 cm (mean ± SD, 2.8 ± 1.2 cm), indicating that patients were on average positioned slightly below the scanner isocenter. There was a slight tendency for smaller patients to be mis-centered lower than larger patients. Average CTDIvol closely fit a quadratic regression curve with respect to mean effective diameter. However, the value of the regression coefficient relating CTDIvol to the patient's vertical position was nearly zero, indicating only a very slight increase in CTDIvol with patient mis-centering for the scanner used in this study. The techniques used here may be useful both for automated evaluation of proper patient positioning in CT and for estimating the radiation dose effects of patient mis-centering for any CT scanner.
Response to ibrutinib in a patient with IgG lymphoplasmacytic lymphoma carrying the MYD88 L265P gene mutation.

Lymphoplasmacytic lymphoma (LPL) is characterized by involvement of the bone marrow and other sites by a monoclonal population of B-cells, lymphoplasmacytoid and plasma cells. In over 95% of LPL ca...
Acceptance of Arsenicals and Antibiotics for Use in Laying Mashes

Abstract THE purpose of this study was to determine to what extent research and advertising by the manufacturers of antibiotics and arsenicals preceded the initial acceptance of these ingredients by manufacturers of laying and breeder rations. Acceptance by the feed manufacturers in Wisconsin was ascertained by reviewing the 1950 to 1960 breeder and laying mash feed tag registrations at the Wisconsin Department of Agriculture by seventeen of the larger feed companies engaged in operations within the state. Advertisements for antibiotics and arsenicals were reviewed for a like period of time in a leading weekly newspaper for feed mill operators, and in a leading monthly poultry magazine for poultry producers. EXPERIMENTAL PROCEDURE The determination of the presence of antibiotics, arsenicals or other bacteriostats used in Wisconsin laying mashes was limited to seventeen of the largest feed companies doing business in the state. Of those selected in 1960 on the basis of their…
A Characterization of Finite Fields

(1967). A Characterization of Finite Fields. The American Mathematical Monthly: Vol. 74, No. 5, pp. 537-538.
Research on gray level distribution information in the sturgeon acoustic image

In this paper,to prove that the gray level is the important information of the acoustic image,and obtain the best Gain value which is useful to partition the fish target,the effect of different gain values on gray level distribution of the acoustic images of Russian sturgeon( Acipenser gueldenstaedti Brandt) was studied,and the fish target was partitioned based on the gray level histogram distribution. The result showed that the best Gain value is 15 d B,under this Gain level,the fish target can be partitioned nicely from the acoustic image even when there is a serious target deformation. The work will provide useful information for sturgeon sonar image recognition and track.
Characterization and modeling of the thermal mechanics of lithium-ion battery cells

Abstract The thermal mechanics of Lithium-ion (Li-ion) batteries is explored with a focus on thermal swelling. Experiments show for the first time that the swelling shape of prismatic battery cells due to temperature variations is significantly different from that due to Li-ion intercalation in unconstrained conditions. In contrast to uniform and orthotropic Li-ion intercalation swelling in a direction perpendicular to electrodes, the nonuniform temperature distribution in the jellyroll and the gaps/voids between electrodes result in distinguishable different swelling shapes. A unique coupled thermal-structural analysis with a simple, but efficient 3-D finite numerical model is proposed to investigate the impact of temperature variations on the thermal behaviors of battery cells. Anisotropic heat conduction and temperature dependency of the coefficient of thermal expansion are taken into account and found to have an impact on temperature distribution and thermal expansion. Experimental validation of the proposed model clearly demonstrates that the coupled thermal-structural analysis with the proposed model can predict accurately the thermal swelling at unconstrained conditions. The solution at pack (constrained) conditions shows that the nonuniform temperature distribution of the jellyroll still plays a critical role for the thermal swelling shape, although the gaps/voids do not occur because of the constraints from spacers in the pack, suggesting that the estimation of core temperature is important. Such an accurate model, able to estimate cell thermal behavior, is beneficial to the design of Li-ion batteries, development of stress or strain sensors, optimum sensor placement, and thermal management of not only single battery cells but also battery packs.
Resilience in American Indian and Alaska Native Public Health: An Underexplored Framework

Objective:To conduct a systematic literature review to assess the conceptualization, application, and measurement of resilience in American Indian and Alaska Native (AIAN) health promotion.Data Sou...
On the performance of label-free resonant photonic biosensors

R photonic biosensing is a powerful technique for label-free detection of biomolecules and viruses. Specifically during the past 5 years photonic biosensning using high quality factor (high-Q) optical microresonators has been the subject of intensive research and development. High-Q optical resonance in micron and sub-micron scale provides a sensitive transduction mechanism for generating a detectable signal proportional to the molecular binding events in label-free affinity based assays. A plethora of microresonator based photonic biosensors have been demonstrated that translate the surface density of bound molecules to measurable changes in optical transmission spectrum using resonant frequency shift. Although a large volume of research has been dedicated to different designs, sensitivity improvement in specific configurations and in few cases simple analysis of the performance, less effort has been spent on developing a comprehensive framework for comparing the practical performance of resonant photonic biosensors as an important class of biosensors. Here after a brief review of the fundamental principles of photonic biosensing using microresonators and related devices, we present a framework for a fair comparison of different devices and sensor configurations. Specifically we explore the detection limit,\ dynamic range and noise in resonant photonic biosensors. This analysis covers Whispering-Gallery microresonators, monolithic microring cavities, gratings, photonic crystals and microcapillaries. The proposed approach also lays the ground for the development of a universal framework that also includes microelectronic and micromechanical biosensors.
Risk of Complications with Simultaneous Cranioplasty and Placement of Ventriculoperitoneal Shunt.

Background The development of hydrocephalus (HCP) necessitating placement of a ventriculoperitoneal shunt (VPS) after decompressive hemicraniectomy occurs at a rate of approximately 5%–15%. The ideal approach for addressing both HCP and a cranial defect remains unclear, and whether concomitant VPS and cranioplasty (CP) increases the risk of complications is uncertain. Methods This is a retrospective cohort study of adult patients who underwent CP and VPS placement for any indication at Harborview Medical Center, Seattle between March 2004 and November 2014 with at least 30 days of follow-up. The primary variable of interest was the timing of CP relative to VPS placement. The outcomes of interest were CP- and VPS-related infections, early (within 1 year of placement) VPS obstruction, and a composite of any of these complications in a single patient. Results The rate of composite outcomes was 15% in the subgroup of patients with simultaneous CP and VPS placement, compared with 29% in the subgroup of patients in whom CP and VPS placement were performed separately, a non–statistically significant difference (P = 0.24). Similarly, there was no statistically significant difference between the subgroups in any of the 3 individual outcomes of interest, which remained after accounting for potential covariates in a multivariate regression model. Conclusions In our study population, there was no difference between simultaneous and separate CP and VPS placement with respect to CP infection, VPS infection, and VPS mechanical failure/obstruction. There is equipoise in the current literature regarding the safety of performing these 2 common procedures simultaneously, with studies of similar size and design finding variable degrees of safety of this practice.
Theodore Dreiser, Temporary Homes, and the Compensatory Commemorative State

This chapter discusses the philosophical ground of Dreiser’s automobile-driven autobiography, A Hoosier Holiday. Dreiser’s text records his failure to reconnect to a stable home as he discovers, on his return to Indiana, that his many childhood homes have all been moved, destroyed, or rendered unrecognizable. His increasing concern over the figure of the homeless wanderer signals his discovery that the detachment that made his realism possible has its limits. Withdrawing into nostalgic sentimentalism, Dreiser’s backward-looking glance seeks to eternalize his experience by producing moments of temporal confusion in which he blurs the past and present.
Archaeologizing “Korean Heritage”: Cultural Properties Management and State Tourist Development

This paper traces the political, economic, and historical backgrounds of the establishment of national cultural institutions that have steered the direction of archaeological investigation, research, and restoration of sites in the Republic of Korea (ROK). It focuses on the activities of the of National Research Institute Cultural Heritage (NRICH , 1969–present), the centralized bureaucracy in charge of planning, budgeting, and developing conservation methods and technology to authenticate, periodize, and classify art and architecture to be registered as ancient sites, museum treasures and representative natural/folk/artistic resources. With the emphasis on salvage archaeological/anthropological fieldwork to make way for massive state-sponsored construction of dams, factories, high-rise apartments, and expressways linking the major ports and cities since the 1970s, only six regions have been designated “culture zones,” where the highest concentration of royal tombs, fortresses, palaces, shrines, and temple complexes have been systematically excavated, preserved and reconstructed as “must-see destinations” and/or proud symbols vouching for the unbroken dynastic continuity and antiquity of Korean civilization. By dissecting the research goals, preservation agendas, and public mission of the NRICH, this paper demonstrates the critical role that state-appointed archaeologists, curators, and specialist committees have played in creating and executing cultural properties’ regulations, research agendas, and educational functions of sites for visitors, targeting both foreign and domestic tourists.
Decellularized matrices in regenerative medicine.

Abstract Of all biologic matrices, decellularized extracellular matrix (dECM) has emerged as a promising tool used either alone or when combined with other biologics in the fields of tissue engineering or regenerative medicine – both preclinically and clinically. dECM provides a native cellular environment that combines its unique composition and architecture. It can be widely obtained from native organs of different species after being decellularized and is entitled to provide necessary cues to cells homing. In this review, the superiority of the macro- and micro-architecture of dECM is described as are methods by which these unique characteristics are being harnessed to aid in the repair and regeneration of organs and tissues. Finally, an overview of the state of research regarding the clinical use of different matrices and the common challenges faced in using dECM are provided, with possible solutions to help translate naturally derived dECM matrices into more robust clinical use. Statement of Significance Ideal scaffolds mimic nature and provide an environment recognized by cells as proper. Biologically derived matrices can provide biological cues, such as sites for cell adhesion, in addition to the mechanical support provided by synthetic matrices. Decellularized extracellular matrix is the closest scaffold to nature, combining unique micro- and macro-architectural characteristics with an equally unique complex composition. The decellularization process preserves structural integrity, ensuring an intact vasculature. As this multifunctional structure can also induce cell differentiation and maturation, it could become the gold standard for scaffolds.
Do You See Me as I See Me? The Effects of Impression Management Incongruence of Actors and Audiences

Based on the idea that both actor and audience member are present in impression management (IM), we argue that the effectiveness of IM usage can only be determined when ratings from both the actor and the audience are considered. Further, we use self-verification theory to explain how IM incongruence may impact workplace outcomes. To test our arguments, we employed congruence analysis (Cheung in Organizational Research Methods 12, 6–33, 2009a). Our approach differs from the majority of extant IM research that employs measures of IM only from the actor’s perspective. By incorporating assessments from the actor and the audience, we bring research on IM back to its theoretical roots and offer a rationale for the varied and inconsistent findings reported in the literature. Using a sample of 175 employees and their supervisors, we examined and compared IM ratings of subordinates’ ingratiation, self-promotion, and exemplification from both the employee and supervisor. Additionally, we investigate the ability of those ratings, individually and together, to predict both subordinate and supervisor ratings of key organizational outcomes. Implications for practice and suggestions for future research also are provided.
Credentials for Practitioners

From their beginnings in 1917, clinical psychology organizations wanted some means by which competent professionals in their field could be identified by the public, some way they could be easily distinguished from quacks and charlatans. As previously described, the plan of having APA certify “consulting psychologists” had to be abandoned in 1927. After World War II, one important event in this domain was the development of the American Board of Examiners in Professional Psychology (ABEPPlater simply ABPP, the word “examiners” being dropped from the board’s title). Other such events included the development of state licensing, of the National Register of Health Service Providers in Psychology, and the continuing discussions of “the master’s issue.”
Computing at the Molecular Level

With the pace of miniaturization of silicon-based computer chips hurtling toward an insurmountable barrier, it has become necessary to envisage a smaller scale on which logic operations can be performed — the molecular scale. This review documents a small fraction of the research currently being undertaken around the globe into the development of systems which, in the solution state, mimic the behavior of switches and logic gates, through the two-dimensional ordering of molecules as a result of the formation of Langmuir films, up to the incorporation of suitably designed molecules into solid-state molecular electronic devices capable of performing useful tasks, such as the retention of memory and the operation of logic gates.
An Introduction to Modeling Muscle and Tendon

To apply mathematically predictable driving forces to the segments of the body using lumped-parameter models of the muscles and tendons.
Site-specific 2D IR spectroscopy: a general approach for the characterization of protein dynamics with high spatial and temporal resolution

The conformational heterogeneity and dynamics of protein side chains contribute to function, but investigating exactly how is hindered by experimental challenges arising from the fast timescales involved and the spatial heterogeneity of protein structures. The potential of two-dimensional infrared (2D IR) spectroscopy for measuring conformational heterogeneity and dynamics with unprecedented spatial and temporal resolution has motivated extensive effort to develop amino acids with functional groups that have frequency-resolved absorptions to serve as probes of their protein microenvironments. We demonstrate the full advantage of the approach by selective incorporation of the probe p-cyanophenylalanine at six distinct sites in a Src homology 3 domain and the application of 2D IR spectroscopy to site-specifically characterize heterogeneity and dynamics and their contribution to cognate ligand binding. The approach revealed a wide range of microenvironments and distinct responses to ligand binding, including at the three adjacent, conserved aromatic residues that form the recognition surface of the protein. Molecular dynamics simulations performed for all the labeled proteins provide insight into the underlying heterogeneity and dynamics. Similar application of 2D IR spectroscopy and site-selective probe incorporation will allow for the characterization of heterogeneity and dynamics of other proteins, how heterogeneity and dynamics are affected by solvation and local structure, and how they might contribute to biological function.
CIUSuite 2: Next-Generation Software for the Analysis of Gas-Phase Protein Unfolding Data.

Ion mobility–mass spectrometry (IM–MS) has become an important addition to the structural biology toolbox, but separating closely related protein conformations remain challenging. Collision-induced...
STFL: Energy-Efficient Data Movement with Slow Transition Fast Level Signaling

Data movement in large caches consumes a significant amount of energy in modern computer systems. Low power interfaces have been proposed to address this problem. Unfortunately, the energy-efficiency of these techniques is largely limited due to undue latency overheads of low power wires and complex coding mechanisms. This paper proposes a hybrid technique for slow-transition, fast-level (STFL) signaling that creates a balance between power and bandwidth in the last level cache interface. Combined with STFL codes, the signaling technique significantly mitigates the performance impacts of low power wires, thereby improving the energy efficiency of data movement in memory systems. When applied to the last level cache of a contemporary multicore system, STFL improves the CPU energy-delay product by 9% as compared to a voltage-frequency scaled baseline. Moreover, the proposed architecture reduces the CPU energy by 26% and achieves 98% of the performance provided by a high-performance baseline.
Transforming a College Biology Course to Engage Students: Exploring Shifts in Evolution Knowledge and Mechanistic Reasoning

Science practices play a central role in meaningful learning. We transformed a college introductory biology course to more practice-based learning environment, in which students constructed knowledge about evolution through explanation and argumentation. These practices, also known as mechanistic reasoning, are a form of scientific inquiry characterized in part by a shift toward reasoning about causal mechanisms. We posit that engaging in these practices may promote a cognitive and social approach to evolution, thereby engaging affective and logic-driven pathways to students’ evolution acceptance. In the intervention, we integrated multiple activities and technological tools to foster students’ explanatory, mechanistic reasoning. This approach was inspired in part by Robbins and Roy’s (2007) inquiry-based teaching unit that yielded improvements in college students’ explanations and acceptance of evolution. In particular, our investigation promoted sense making, evaluating, argumentation, and consensus building while providing rich, meaningful learning about natural selection. This data-driven strategy engaged students in evolutionary phenomena directly, another avenue to promoting conceptual change. This chapter presents results across a spectrum of evolution literacy components, including (1) conceptual change around natural selection, (2) mechanistic reasoning related to natural selection, and (3) engagement in argumentation around data.
Identification of recurrent activating HER2 mutations in primary canine pulmonary adenocarcinoma

Purpose: Naturally occurring primary canine lung cancers share clinicopathologic features with human lung cancers in never-smokers, but the genetic underpinnings of canine lung cancer are unknown. We have charted the genomic landscape of canine lung cancer and performed functional characterization of novel, recurrent HER2 (ERBB2) mutations occurring in canine pulmonary adenocarcinoma (cPAC). Experimental Design: We performed multiplatform genomic sequencing of 88 primary canine lung tumors or cell lines. Additionally, in cPAC cell lines, we performed functional characterization of HER2 signaling and evaluated mutation-dependent HER2 inhibitor drug dose-response. Results: We discovered somatic, coding HER2 point mutations in 38% of cPACs (28/74), but none in adenosquamous (cPASC, 0/11) or squamous cell (cPSCC, 0/3) carcinomas. The majority (93%) of HER2 mutations were hotspot V659E transmembrane domain (TMD) mutations comparable to activating mutations at this same site in human cancer. Other HER2 mutations were located in the extracellular domain and TMD. HER2V659E was detected in the plasma of 33% (2/6) of dogs with localized HER2V659E tumors. HER2V659E cPAC cell lines displayed constitutive phosphorylation of AKT and significantly higher sensitivity to the HER2 inhibitors lapatinib and neratinib relative to HER2-wild-type cell lines (IC50 2,500 nmol/L in HER2WT). Conclusions: This study creates a foundation for molecular understanding of and drug development for canine lung cancer. These data also establish molecular contexts for comparative studies in dogs and humans of low mutation burden, never-smoker lung cancer, and mutant HER2 function and inhibition.
What Drives Pay for Chief Investment Officers at Endowments

This paper examines the compensation of Chief Investment Officers (CIOs) of nonprofit endowments, which have different economic models and monitoring arrangements than those of other institutional investors. We find that compensation reflects the demands of the job, abilities and experience that individuals bring to the job and how well the endowment performs. Pay relies heavily on bonuses and is positively linked to the CIO's education and professional experience. Large endowments hire CIOs with stronger backgrounds, pay them more and structure pay significantly linked to endowment performance. Even controlling for size, compensation depends on an endowment’s governance and location. The results are consistent with the increased investment skills needed to manage large pools of capital often involving alternative assets, and with differences in labor market and monitoring arrangements across endowments. For large endowments the sensitivity of pay to performance is greater than often reported for mutual fund managers.
Dilated convolutional recurrent neural network for monaural speech enhancement

In this study, we have proposed a novel dilated convolutional recurrent neural network for real-time monaural speech enhancement. Our proposed model incorporates dilated causal convolutions with a long short-term memory (LSTM) layer and skip connections to track a target speaker from a single channel noisy-reverberant mixture. Our model was evaluated in simulated rooms with different reverberation times and unseen background noises. Experimental results show significant improvements in objective speech intelligibility and speech quality of the enhanced speech using proposed model compared to LSTM, gated residual network (GRN) and convolutional recurrent network (CRN) models. Moreover, this model has better generalization to untrained speakers and unseen noises compared to LSTM, GRN and CRN, while it has fewer trainable parameters and can operate in real-time applications.
Building a Tool Kit for Medical and Dental Students: Addressing Microaggressions and Discrimination on the Wards.

Introduction Microaggressions, subtle slights related to characteristics such as race, gender, or sexual orientation, in a clinical setting can sabotage the therapeutic alliance. Curricula tailored...
Self-Concept Influences the Hopes and Psychological Well- Being of Cancer Survivors in Surabaya, Indonesia: A Cross- Sectional Study

Background: The stigma of cancer as a deadly disease greatly affects the patient’s perspective in shaping self-concept, which impacts on hopes and influences the stability of psychological well-being. The purpose of this study was to prove that the self-concept influences the hopes and psychological well-being of cancer survivors. Methods: This was a cross-sectional study. Samples were 90 cancer survivors from three public health centers in Surabaya, Indonesia taken by simple random sampling. All participants completed the instruments of the Tennessee Self-Concept Scale, Herth Hope Index, and Ryff’s Psychological Well-Being Scale. All the instruments were valid and reliable based on the test. Ethical feasibility has been conducted. The Pearson Product-Moment Correlation Test was applied to analyze the data with P < .05. Results: The demographic characteristics of cancer survivors include the age majority of 46-65 years (53%), female sex (80%), married (61%), having stage-III cancer (44%), diagnosed of cancer for 1–6 years (56%), having support system from nuclear families (73%), and actively involved in the community (66%). The mean score of self-concept is 78.2, hope 38.2, and psychological well- being 76.3. Self-concept had a significant effect on hope ( r = .783, P = .000) and psychological well-being ( r = .611, P = .000) Conclusions: Cancer survivors who had positive self-concepts are more likely to accept themselves, which triggers the formation of high hope for recovery and the achievement of positive psychological well-being.
Polygenic Risk Scores Predict the Development of Alcohol and Nicotine Use Problems from Adolescence through Young Adulthood

Abstract Importance Molecular genetic studies of alcohol and nicotine use have identified hundreds of genome-wide risk loci. Few studies have examined the influence of aggregate genetic risk on substance use trajectories over time. Objective We examined the predictive utility of drinking and smoking polygenic risk scores (PRS) for alcohol and nicotine use from late childhood to early adulthood, substance-specific versus broader-liability effects of the respective PRS, and if PRS performance varied between regular consumption versus pathological use. Design Latent growth curve models with structured residuals were used to assess the predictive utility of drinks per week and regular smoking PRS for measures of alcohol and nicotine consumption and problematic use from age 14 to 34. Setting PRS were generated from the largest discovery sample for alcohol and nicotine use to date (i.e., GSCAN), and examined for associations with alcohol and nicotine use outcomes in the Minnesota Twin Family Study (MTFS). Participants Participants were members of the MTFS (N=3225), a longitudinal study investigating the development of substance use disorders and related conditions. Main Outcomes and Measures Outcomes included alcohol and nicotine use disorder symptoms as defined by the Diagnostic and Statistical Manual of Mental Disorders, measures of alcohol and nicotine consumption (i.e., drinks per occasion, cigarettes per day), and composite variables for alcohol and nicotine use problems. Results The drinks per week PRS was a significant predictor of problematic alcohol use at age 14 and increases in problematic use during young adulthood. The regular smoking PRS was a significant predictor for all nicotine use outcomes. After adjusting for the effects of both PRSs, the regular smoking PRS demonstrated incremental predictive utility for most alcohol use outcomes and remained a significant predictor of nicotine use trajectories. Conclusions and Relevance Higher PRS for drinks per week and regular smoking were each associated with more problematic levels of substance use over time. Additionally, the regular smoking PRS seems to capture both nicotine-specific and non-specific genetic liability for substance use problems, and may index genetic risk for externalizing behavior in general. Longitudinal PRS prediction approaches may inform personalized substance use intervention approaches. Key Points Question Do polygenic risk scores (PRS) for drinking and smoking predict problematic alcohol and nicotine use from late childhood to early adulthood? Findings In the current study, drinks per week and regular smoking PRS generated from the GWAS & Sequencing Consortium of Alcohol and Nicotine use (GSCAN) were associated with higher levels of problematic alcohol and nicotine use assessed longitudinally from ages 14 to 34 in a sample of 3225 individuals. Meaning Polygenic risk scores validated within longitudinal study designs may help inform future substance use intervention and prevention efforts.
Identification of neural and psychophysical predictors of headache reduction after cognitive behavioral therapy in adolescents with migraine.

ABSTRACT Cognitive behavioral therapy (CBT) is a psychological intervention that involves development of coping strategies to reduce the experience of pain. Although CBT is a promising intervention to reduce headache days in patients with migraine, it may not be effective for all patients. Thus, there is a need to identify markers that could predict which patients will respond to CBT. We aimed to determine whether baseline brain function and amygdalar connectivity, assessed by functional magnetic resonance imaging, or pain modulation capacities, assessed by the conditioned pain modulation (CPM) response, can predict a reduction in headache days after CBT in adolescents with migraine. Patients with migraine (n = 20; age range 10-17 years) completed 8 weekly CBT sessions. The CPM response was examined in the trapezius and the leg. Headache days significantly decreased after CBT (P < 0.001). Greater functional connectivity before CBT between the right amygdala and frontal gyrus, anterior cingulate cortex, and precentral gyrus was related to greater headache reduction after CBT. Greater reduction in headache days after CBT was related with less efficient CPM response before CBT at the trapezius (r = -0.492, P = 0.028) but not at the leg. This study found that headache reduction after CBT was related to right amygdala connectivity with frontal and sensorimotor regions at baseline as well as baseline pain modulation capacities. These findings suggest that individual differences in brain function and pain modulation can be associated with clinical improvements and help with determination of CBT responsiveness.
A novel female-specific circadian clock mechanism regulating metabolism

Abstract Circadian clocks enable organisms to predict and align their behaviors and physiologies to constant daily day-night environmental cycle. Because the ubiquitin ligase Siah2 has been identified as a potential regulator of circadian clock function in cultured cells, we have used Siah2-deficient mice to examine its function in vivo. Our experiments demonstrate a striking and unexpected sexually dimorphic effect of Siah2 deficiency on the regulation of rhythmically expressed genes. The absence of Siah2 in females, but not in males, altered the expression of core circadian clock genes and drastically remodeled the rhythmic hepatic transcriptome. Siah2 loss, only in females, increased the expression of 100’s of genes selectively at mid-day, resulting in a ∼70% increase in the number of rhythmically expressed genes, and shifted the expression of 100’s of other genes from a mid-night peak, to a mid-day peak. The combined result is a near inversion of overall rhythmicity in gene expression selectively in Siah2-deficient females. This dramatic reorganization created a substantial misalignment between rhythmic liver functions and feeding/behavioral rhythms, and consequently impaired daily patterns of lipid/lipoprotein metabolism and metabolic responses to high-fat diet. Collectively, our results suggest that Siah2 is part of a female-specific circadian mechanism important for maintaining metabolic homeostasis and may play a key role in the establishing sexual dimorphisms in metabolism. Signficance statement Circadian clocks drive daily rhythms in many aspects of our physiology, optimally aligning functions across the day-night cycle. How circadian clocks drives these rhythms is thought to be due to largely similar transcriptional pathways and mechanisms in males and females, although some rhythms are modulated by sex and growth hormones. In this study, we present data that uncover the surprising existence of a female-specific transcriptional mechanism that is essential for the proper rhythmic control of gene expression in the liver. Disrupting this mechanism substantially impairs the circadian regulation of lipid and cholesterol metabolism selectively in females, impairing their resistance to diet-induced obesity. These results reveal that circadian clocks may be broadly coupled to physiological rhythms using unexpected sex-specific mechanisms.
The Quaker and the Gamecock: Nathanael Greene, Thomas Sumter, and the Revolutionary War for the Soul of the South: Philadelphia, PA: Casemate, 222 pp., $34.95, ISBN 978-1-61200-781-6, Publication Date: September 2019

Andrew Waters’s The Quaker and the Gamecock: Nathanael Greene, Thomas Sumter, and the Revolutionary War for the Soul of the South addresses the Southern Campaign of the War of American Independence...
Probing the Fiscal Implications of Multipurpose Development Districts: An Institutional Analysis of Florida Community Development Districts:

Across the U.S., private land developers are forgoing traditional financing of new suburban infrastructure in favor of an institutional innovation in special government—multipurpose development dis...
Characterization of interactive force acting on colloidal particles near an electrode in presence of a high-frequency (>10 kHz) AC electric field using particle diffusometry

Colloidal particles like polystyrene beads and metallic micro and nanoparticles are known to assemble in crystal-like structures near an electrode surface under both DC and AC electric fields. Various studies have shown that this self-assembly is governed by a balance between an attractive electrohydrodynamic (EHD) force and an induced dipole-dipole repulsion (Trau et al., 1997). The EHD force originates from electrolyte flow caused by interaction between the electric field and the polarized double layers of both the particles and the electrode surface. The particles are found to either aggregate or repel from each other on application of electric field depending on the mobility of the ions in the electrolyte (Woehl et al., 2014). The particle motion in the electrode plane is studied well under various conditions however, not as many references are available in the literature that discuss the effects of the AC electric field on their out-of-plane motion, especially at high frequencies (>10 kHz). Haughey and Earnshaw (1998), and Fagan et al. (2005) have studied the particle motion perpendicular to the electrode plane and their average height from the electrode mostly in presence of DC or low frequency AC ( 10 kHz) electric field on the particles’ motion perpendicular to the electrode plane.
Mass Salmonella Poisoning by the Peanut Corporation of America: State-Corporate Crime Involving Food Safety

Animal feces in food causes outbreaks of salmonella poisoning, whose assault on the body results in several days of diarrhea, vomiting and even death. This paper looks at the massive distribution of salmonella-contaminated peanuts in 2008–2009 that caused nine deaths, 11,000–20,000 illnesses and the recall of 4000 products in the US. The Peanut Corporation of America operated filthy, sometimes unregistered, plants and shipped products to major food manufacturers and schools after receiving test results positive for salmonella. This corporate crime was facilitated by substantial weaknesses in regulation, and is thus a state-facilitated corporate crime. This case study is developed by looking at the peanut plant conditions, decisions of executives, regulatory failure, and overall response. The conclusion asks about the puzzle of the state responding to a crime it facilitated, and how to understand the role a corporation victimizing another corporation plays into the response.
Solid State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation

The preformulation and formulation of new chemical entities (NCEs) have evolved considerably in the past 50 years, being driven largely by dramatic changes in the regulation of drug products. The objective of this chapter is to discuss examples of several well-known and ubiquitous issues in preformulation/formulation data analysis and interpretation. These issues have proved extremely challenging for scientists as they have attempted to develop drugs and drug products due to the inability of standard modeling or traditional mathematical approaches to mimic the processes or provide a predictive way forward. However, interpretation of the problem using different approaches originating from the fields of dynamical systems, chaos, complexity and fractals, tenable solutions, and even deeper understanding has been facilitated.
The effect of changes in habitat conditions on the movement of juvenile Snail Kites Rostrhamus sociabilis

The degradation of habitats due to human activities is a major topic of interest for the conservation and management of wild populations. There is growing evidence that the Florida Everglades ecosystem continues to suffer from habitat degradation. After a period of recovery in the 1990s, the Snail Kite Rostrhamus sociabilis population suffered a substantial decline in 2001 and has not recovered since. Habitat degradation has been suggested as one of the primary reasons for this lack of recovery. As a consequence of the continued degradation of the Everglades, we hypothesized that this would have led to increased movement of juvenile Kites over time, as a consequence of the need to find more favourable habitat. We used multistate mark-recapture models to compare between-site movement probabilities of juvenile Snail Kites in the 1990s (1992–95; which corresponds to the period before the decline) and 2000s (2003–06; after the decline). Our analyses were based on an extensive radiotelemetry study (266 birds tracked monthly over the entire state of Florida for a total period of 6 years) and considered factors such as sex and age of marked individuals. There was evidence of increased movement of juvenile Snail Kites during the post-decline period from most of the wetland regions used historically by Kites. Higher movement rates may contribute to an increase in the probability of mortality of young individuals and could contribute to the observed declines.
The Topology of Algebraic Quotients

(0.0) This is an expanded version of my talk of the above title at the Rutgers Conference on Topological Methods in Algebraic Transformation Groups, April 4–8, 1988. I report on recent work which shows there is a strong interconnection between the theory of quotients in the algebraic category (reductive groups) and in the topological category (compact groups). It turns out that one can represent quotient spaces of reductive groups as quotient spaces of compact groups. The precise method of doing this has important topological consequences for quotients of reductive groups and also provides some new insight into quotients of compact groups. I hope that my exposition will make these results more accessible to all.
Two-Class Priority Queueing System with State-Dependent Arrivals

In this paper, we present a performance analysis of a 2-dimensional preemptive priority queueing system with state-dependent arrivals. Using a Markovian formulation we first compute the steady state distribution for the queue length of both classes. Then, waiting times and busy periods are characterized through (i) first and second moments and (ii) the approximation of their cumulative distribution functions (cdf) and Laplace–Stieltjes transforms (LST). We derive these approximations connecting bounds in the Laplace domain with bounds on the original time domain. We also, study the behavior of the inter-departure time for each class. Finally, we conclude the paper with a set of computational experiments testing our results.
CpG Oligodeoxynucleotides Enhance the Capacity of Adenovirus-mediated CD154 Gene Transfer to Generate Effective B-Cell Lymphoma Vaccines

Activation of CD40 by CD154 induces antigen-presenting cells (APC) to express immune costimulatory molecules, thereby enhancing their APC activity. Oligonucleotides (ODN), containing immunostimulatory DNA sequences (ISS) with nonmethylated CpG dinucleotides in a defined motif, also can induce similar changes in APC. In this study, we examined whether infection with recombinant adenovirus (Ad) encoding CD154 and/or treatment with ISS-ODN could enhance the capacity of A20 murine B lymphoma cells to function as APCs capable of inducing a syngeneic antilymphoma immune response. High-level expression of CD154 after infection with Ad-CD154 induced up-regulation of immune costimulatory molecules on A20 cells, as did incubation with ISS-ODN. Treatment of A20 cells with ISS-ODN also enhanced surface expression of αv integrins, making them significantly more susceptible to Ad infection than nontreated A20 cells. In syngeneic mixed-lymphocyte reactions with BALB/c splenocytes, A20 cells activated with ISS-ODN and then transduced with Ad-CD154 were significantly more effective APCs than Ad-CD154 transduced cells, which, in turn, were significantly more effective than A20 cells treated with ISS-ODN alone. Also, injection of mice with ISS-activated, Ad-CD154-infected cells induced significantly better A20-specific immune responses against A20 cells, as assessed via enzyme-linked immunospot analysis in vitro and immune prophylaxis against subsequent challenge with A20 lymphoma cells in vivo . These data demonstrate that CpG-containing oligonucleotides can serve as an adjuvant for Ad-mediated gene therapy of B-cell malignancies.
From declining western civilization towards wise civilization competing and sustaining in business-driven globalization

The purpose of this investigation is to analyze how Western civilization’s transformation into Global civilization impacts the well-being of civilization and humans in the 21 st century. The financial crash of 2008 will be one of the topics of that analysis along with other consequences which may lead to the formation of the Death Triangle of Civilization in 2050-2300. In order to sustain human existence on Earth, we must develop Wise civilization. Its main ideas will be defined and the possibilities for its implementation will be assessed.
Promoting and Teaching Information Literacy on the Internet: Surveying the Web Sites of 264 Academic Libraries in North America

A survey was conducted between July and November 2012 to determine how academic libraries in the United States and Canada marketed and delivered information literacy on the Web. A random sample of 264 institutions was taken from Peterson's Four-Year Colleges 2012, and the authors checked each Web site of the academic libraries of the institutions in the sample for instruction-related activities. Only 65 percent of the libraries in the sample advertised library instruction as a service on the Web, while 64 percent of the libraries boasted research guides and tutorials. Sixteen percent of the libraries provided direct links to ACRL's Information Literacy Competency Standards for Higher Education, and 24 percent made an effort to explain and define the term “information literacy” to their users. The authors hope the findings can help determine how academic libraries are currently using the Internet to increase information literacy on the Web and set a new platform for better strategies for advocating informa...
Russian perspectives on elder abuse: an exploratory study.

ABSTRACT The purpose of this exploratory study was to analyze Russian perceptions of elder abuse as reflected in their examples of abusive behavior from an adult child to an aging parent. Also of interest was the possibility of gender differences in the Russian perspectives on elder abuse. The convenience sample consisted of 21 Russian participants (10 males, 10 females, and one without gender identified), who provided examples of extreme, moderate, and mild abuse from an adult child towards an aging parent. Most examples of extreme abuse were forms of physical violence. Typical examples of moderate abuse were instances of psychological aggression–particularly verbal aggression–and neglect. The most common examples of mild abuse were verbal aggression and neglect. One-way analyses of variance revealed statistically significant gender differences in the number of references to psychological aggression in general and to verbal aggression in particular in the examples of moderate abuse, with females giving m...
Utilization of a radioimmunoassay to detect the generation of Arg-Pro-Pro-Gly-Phe, a stable endproduct of bradykinin metabolism (from cultured rat aortic smooth muscle cells exposed to bradykinin)

Abstract The peptide hormone bradykinin is a mediator in many physiological and pathological processes. The generation and, to a limited extent, metabolism occur at the sites of action. The short half-life of bradykinin (∼15 s) renders measurements of its concentration in bodily fluids difficult. As a result, recent methods utilizing either ELISA or HPLC/mass spectrometry, have been developed for the measurement of the stable metabolic endproduct of bradykinin, i.e., the pentapeptide Arg-Pro-Pro-Gly-Phe (RPPGF; BK[1–5]). Both have been successfully used to quantitate levels of RPPGF in plasma, pulmonary and nasal exudates. In this study, we demonstrate the characterization and utility of a radioimmunoassay for the measurement of RPPGF, using a newly synthesized radioiodinated analogue of RPPGF, i.e., RPPG(125I)F. This radioimmunoassay shows an IC50 of 80.5±7.4 pg/tube (n=23) with a linear range of detection between 10 and 500 pg/tube. The assay was used to demonstrate the time-dependent generation of RPPGF by cultured rat aortic vascular smooth muscle cells exposed to bradykinin (100 ng/ml). Peak generation of RPPGF was 74.5±9.7 pmol/well (n=5) after 24 h of incubation. Captopril, an inhibitor of angiotensin-converting enzyme (kininase II), inhibited generation in a concentration-dependent manner. The results characterize a new radioimmunoassay for the stable metabolic endproduct of bradykinin, RPPGF.