cssi/SciSciGPT-SciSciNet huggingface dataset:
"The Level of the Beasts that Perish": Animalized Text in Charlotte Elizabeth Tonna's Helen Fleetwood

The Level of the Beasts That Perish”: Animalized Text in Charlotte Elizabeth Tonna’s Helen Fleetwood Christie Peterson Department of English Master of Arts Although Charlotte Elizabeth Tonna’s 1839 social reform novel Helen Fleetwood has long been understood as a commentary on the dehumanizing effects of factory work, her use of animals to represent factory workers has not been considered in analyses of her depictions of dehumanization. Considering both the growing interest in the animal/human divide during the early nineteenth century and Tonna’s own direct contributions to discussions about animals, in this essay I examine the role that animals play in negotiating definitions of humanity and nature in the novel. I argue that idealized, “Edenic” animals and corrupted, “industrial” animals are integral to Tonna’s juxtaposition of the pre-industrialized countryside and the industrial city; I also explore how “animality” transcends the content of the novel and becomes an element of the novel’s methodology and conventions. Using the animality of Helen Fleetwood as a case study, I conclude that Victorian social reform writers not only idealized nature to serve their arguments but were also constrained and somewhat undermined by a kind of “nature” that lay beyond their narrative control.
Synthesis, Structure, and Properties of Ln4Ni3O10-δ (Ln = La, Pr, and Nd)

The Ruddlesden-Popper nickelates Ln 4 Ni 3 O 10-δ , with Ln = La, Pr, and Nd, have been synthesized by a precursor method. Power X-ray diffraction studies show orthorhombic symmetry with space group Fmmm for all three compounds; however, electron diffraction patterns of single crystals show that the space group symmetry is lower than F or C. The orthorhombic unit cell parameters decrease monotonically with decreasing effective ionic radius of the lanthanide ion. The distortion from ideal tetragonal symmetry and the orthorhombic strain increase with decreasing radius of the lanthanide ion; Nd was the smallest lanthanide for which Ln 4 Ni 3 O 10-δ could be stabilized. Pr 4 Ni 3 O 10-δ and Nd 4 Ni 3 O 10-δ are oxygen deficient (δ ∼ 0.15), while La 4 Ni 3 O 10 is nearly stoichiometric. The resistivity measurements indicate metallic temperature dependence for La 4 Ni 3 O 10 , and a metal-to-metal transition for Pr 4 Ni 3 O 10-δ and Nd 4 Ni 3 O 10-δ at 145 and 165 K, respectively. These anomalies are attributed to charge-density-wave driven instabilities and are confirmed by differential scanning calorimetry to coincide with first-order structural phase transitions. The magnetic susceptibility of metallic La 4 Ni 3 O 10 is nearly temperature independent above 100 K, and shows paramagnetic behavior at lower temperatures. Pr 4 Ni 3 O 10-δ and Nd 4 Ni 3 O 10-δ show paramagnetic behavior in the temperature range 4-300 K, due to the large magnetic contributions of the lanthanides to the total moment.
Language Usage as a Means of Maintaining Classroom Discipline.

What do teachers know about language and discipline? Do they perceive them to be related? Child-rearing authorities, classroon management experts, and self-improvement program advocates state that specific language usage is a component part of maintaining good classroom management. This article is a compilation of various programs as they relate to establishing and maintaining discipline in the classroom. As a motivational device for your continuing reading, there will be several short exercises which will be divided into sections representing different philosophical approaches. After the questions in each section, there will be an explanation of the correct answer according to the particular authority. The directions for all the exercises will be as follows: Read each statement below and circle the
A Web Services Approach for Sharing Remote Laboratory Resources

Because of their promise of significant benefits to all stakeholders in the laboratory education process, an increasing number of shared remotely accessible student laboratory resources are being developed by many educational institutions around the world. These resources include both remote laboratories, which are based on actual experimental devices as well as virtual laboratories, which represent software simulations of experiments. Web services are becoming more and more popular as an efficient technology for sharing distributed applications and structured information. In this article, we will propose a Web services based approach for the development and implementation of a scalable platform for providing a large variety of educational laboratory experiences to widely dispersed student audiences. We will present the general methodology for locating and utilizing distributed remote laboratory resources based on this Web services oriented system architecture. In particular, we will describe the overall system architecture, the design of the communication between the various system components and system users, the approach taken in managing the dynamic set of distributed resources in an efficient manner, the software architecture employed in searching for specific laboratory resources with certain functionalities as well as some challenges arising in the design and implementation of such a system.Copyright © 2006 by ASME
Efficacy of dietary zinc supplementation on catch-up growth after protein malnutrition

Abstract Young male rats were subjected to protein malnutrition for 21 days and then rehabilitated for 21 days with diets that varied in zinc content. The three levels of dietary zinc used during recovery were 12, 33, and 72 ppm. Compared with a baseline group, serum total protein, albumin, zinc, and tibia zinc were all significantly decreased during the period of malnutrition. During recovery the malnourished rats consumed less food but grew more than the age-matched control rats. Feed efficiency (weight gain/food intake) of the recovering rats was twice the rate of the controls. Dietary zinc in excess of 12 ppm did not significantly increase linear growth or lean tissue weights, but did increase serum total protein, albumin, zinc, and tibia zinc during recovery from protein malnutrition.
Cardiac response to diving in wild ducks

Abstract 1. 1. Submersion of the head in water causes bradycardia in the Redhead (Aythya americana), Lesser Scaup (Aythya affinis), Ruddy Duck (Oxyura jamaicensis) and the Pintail (Ansa acuta), 2. 2. Differences in development of bradycardia were demonstrated among the four species. Redheads and Ruddy Ducks have the most rapid response and the sharpest decline in heart rate. Pintails and Lesser Scaups showed a lesser decline and rate of development of bradycardia, Pintails showing the least. 3. 3. Redheads, Lesser Scaups and Ruddy Ducks reached an average decline of 45 heartbeats/min within 5 sec after submergence. Pintails reached this average decline after 20 sec of submergence.
Studies of the Chemical Basis of the Origin of Protein Synthesis: Initiation and Direction of Peptide Growth

The data presented in this paper show that the ease of nonenzymatic activation of carboxylic acids by ATP at pH 5 varies directly with the pKa of the carboxyl group, and is consistent with the idea that it is the protonated form of the carboxyl group which participates in the activation reaction. Consequently, since most N-blocked amino acids have higher pKas than do their unblocked forms, they are activated more readily, and it has been demonstrated that this principle applies to peptides as well, which are activated more rapidly than single amino acids. It is proposed that this fact may be partly responsible for the origin of two important features still observed in contemporary protein synthesis: (1) initiation in prokaryotes is accomplished with an N-blocked amino acid, and (2) elongation in all living systems occurs at the carboxyl end of the growing peptide.
Observation of muon pairs in high-energy hadron collisions

Muon pairs with effective masses between 1 GeV/c/sup 2/ and 6.5 GeV/c/ sup 2/ have been observed in the collisions of 30-GeV protons with a uramium target. The production cross section was seen to vary smoothly with mass exhibiting no resonant strtucture. Data were taken at incident proton emergies of 22, 25, 28.5, and 29.5 GeV. Within the experimental aperture the total cross section increased with energy by a factor of 5. The experimental results are compared with the predictions of several theoretical models. Limits are presented for the contributions to the signal from both massive muon-pair resonances and antiproton-proton annihilation. Implications are presented for higher-energy accelerators, using current ideas involving scaling. (auth)
Erratum to: Jewish Nonprofit Organizations in the U.S.: A Preliminary Survey

The 1927 study was not repeated, and it is easy to imagine why. In 2001 the Research Department of United Jewish Communities conducted a census of American synagogues (reported in Schwartz, Scheckner, and Kotler-Berkowitz 2002). This was no simple matter; a tremendous amount of conceptual and methodological work had to be undertaken before the census itself could even begin. Two of the authors, Jim Schwartz and Jeffrey Scheckner, remarked elsewhere (Jones et al. 2002, p. 535) that ‘‘The process [of planning and conducting the census] was far more complicated and cumbersome than anticipated....’’ Given their experience, it is clear that the effort required to describe all, or even most, Jewish organizations would be truly staggering.
Relationships Between Efficiency of Milk Production and Ruminal Volatile Fatty Acids of Cows Fed Isocaloric (ENE) Rations of Varied Concentrate Levels

Summary Ruminal VFA determinations were made on four rumen fistulated Holsteins fed rations in which 90, 70, 50, or 30% of the ENE was supplied by concentrates. Digestible energy (DE) and TDN were determined along with milk production. The requirements above maintenance per pound FCM from the 90, 70, 50, and 30% concentrate rations, respectively, were 0.55, 0.61, 0.71, and 0.82 therm DE and 0.28, 0.31, 0.35, and 0.40 lb TDN The ENE required for FCM production was similar on all rations. The relative amount of acetic acid decreased, and butyric acid increased as the per cent of concentrate in the ration increased (P
Pharmacologic Management of Atrial Fibrillation and Flutter

Atrial fibrillation is the most commonly encountered arrhythmia requiring therapy and is associated with significant morbidity, a reduced quality of life, an increased risk for mortality, a significant likelihood of hospitalization, an increased risk for stroke and systemic embolism, and significant costs. Both rate control and rhythm control have been shown to improve quality of life. Neither as a strategy has been proven to reduce mortality versus the other; however, in some series the attainment and maintenance of sinus rhythm has had superior outcomes if risks from therapy are not encountered (especially those of amiodarone). In patients with markers of an increased risk for stroke, anticoagulation with warfarin is essential. In all patients, rate control is also necessary so as to reduce both symptoms and the risk for a tachycardia-induced cardiomyopathy. The choice of rhythm control strategy must be individualized based on patient characteristics. This chapter will review the considerations necessary for choosing appropriate pharmacologic therapies as well as the therapeutic agents themselves.
Combined study of b→sγ and the muon anomalous magnetic moment in gauge-mediated supersymmetry breaking models

We study both the branching ratio for $\stackrel{\ensuremath{\rightarrow}}{b}s\ensuremath{\gamma}$ decay and the muon anomalous magnetic moment, ${a}_{\ensuremath{\mu}}\ensuremath{\equiv}(g\ensuremath{-}{2)}_{\ensuremath{\mu}}/2,$ in the minimal supersymmetric standard model with gauge-mediated supersymmetry breaking. Combining new experimental data on ${a}_{\ensuremath{\mu}}$ and the branching ratio for $\stackrel{\ensuremath{\rightarrow}}{b}s\ensuremath{\gamma},$ strong limits on the parameter space of these models are derived. We find that this combined study leads to much stronger constraints on the parameter space of the model than those from either $\stackrel{\ensuremath{\rightarrow}}{b}s\ensuremath{\gamma}$ or ${a}_{\ensuremath{\mu}}.$ In particular, the region of large $\mathrm{tan}\ensuremath{\beta}$ is extremely limited, which would have been otherwise allowed. We include the supersymmetric one-loop correction to the mass of b quark, ${m}_{b},$ and find that in order to have a correct value of ${m}_{b},$ the region of large $\mathrm{tan}\ensuremath{\beta}$ and $\ensuremath{\mu}l0$ (in our convention) is not allowed in these models. The region of large $\mathrm{tan}\ensuremath{\beta}$ and $\ensuremath{\mu}g0$ is also strongly constrained. We present bounds on supersymmetric particle masses as a function of $\mathrm{tan}\ensuremath{\beta}.$
A dose-response study of the effect of levobunolol on ocular hypertension.

We conducted a randomized, double-masked, dose-response study of the ocular hypotensive effect of the β-adrenergic blocker, levobunolol. A single drop of placebo or levobunolol (at concentrations of 0.03%, 0.3%, 0.6%, 1%, and 2%) was administered to one eye of each of 48 patients with ocular hypertension. The 0.3% and 0.6% concentrations decreased intraocular pressure significantly from baseline levels compared to placebo at one, two, and four hours after treatment. The 1% and 2% concentrations decreased intraocular pressure significantly from baseline compared to placebo at one, two, four, six, eight, and 12 hours after administration. No objective or subjective side effects were noted, and no substantial changes in visual acuity, pupil diameter, pulse rate, or blood pressure were recorded during the study. These results appear to justify long-term studies of levobunolol for the treatment of increased intraocular pressure.
Bifurcations of relative equilibria in the 4- and 5-body problem

The equilateral triangle family of relative equilibria of the 4-body problem consists of three particles of mass 1 at the vertices of an equilateral triangle and the fourth particle of arbitrary mass m at the centroid. For one value of the mass m this relative equilibrium is degenerate. We show that families of isosceles triangle relative equilibria bifurcate from the equilateral triangle family as m passes through the degenerate value. The square family of relative equilibria of the 5-body problem consists of four particles of mass 1 at the vertices of a square and the fifth particle of arbitrary mass m at the centroid. For one value of the mass m this relative equilibrium is degenerate. We show that families of kite and isosceles trapezoidal relative equilibria bifurcate from the square family as m passes through the degenerate value.
Exploiting the adaptive properties of a probing device for TCP in heterogenous networks

End-to-end protocols lack the functionality to efficiently adjust their error control strategies to the distinct characteristics of network environments and to specific constraints of communicating devices. In the context of heterogeneous networks, error control needs to be responsive to the nature of the errors spanning a conservative-through-to-aggressive behavioral spectrum. In the context of mobile, battery-powered devices, the recovery strategy should yield good performance with a minimal transmission effort. We exploit the potential of a probing device to implement an adaptive error control strategy efficiently by shaping data transmission to be assorted with the distinctive characteristics of the underlying wired or wireless network components. We graft our mechanism onto standard TCP; we present encouraging experimental results with wired, wireless and mobile networks.
PATHOLOGIC ASSESSMENT OF THE SURGICAL SPECIMEN

A dramatic increase has occurred in the number of radical prostatectomies performed each year. At the author's center, approximately 15 radical prostatectomies were performed per year in the early 1980s in comparison with almost 1000 radical prostatectomies last year. Concurrently, there has been an explosion in articles dealing with the relation of conventional histologic parameters and biomarkers to progression following radical prostatectomy. This article reviews the handling of radical prostatectomy specimens and the relation of findings derived from the prostatectomy specimen to the prediction of postoperative prognosis.
Food limitation of production by adult Acartia tonsa in Narragansett Bay, Rhode Island1

Egg production, dry weight, cephalothorax length, and condition factor were measured for adult Acartia tonsa females collected twice weekly from Narragansett Bay, R.I., during summer 1979 and incubated in ambient bay water and in ambient bay water enriched with laboratorycultured algae. Egg production, dry weight, and condition factor of copepods in the ambient bay water fluctuated considerably (ranges 1.6-51.6 eggsafemale-‘*d-l, 7.37-16.60 fig dry wt, and 1.09-2.37 condition factor) and closely followed the seasonal trends in Chl a and particulate carbon and nitrogen. Cephalothorax length remained fairly constant during the study. The overall mean egg production rate, dry weight, and cephalothorax length of the copepods after incubation for 48 h in the algae-enriched water were significantly greater than for copepods incubated in ambient bay water (mean values 45.9 vs. 25.3 eggsafemale-‘*d-l, 13.2 vs. 11.8 kg dry wt, and 901.7 vs. 891.8 pm long). Since body size and egg production in adult A. tonsa responded rapidly to a change in food availability, the copepods must have been continuously food limited in Narragansett Bay during summer.
Molecular dynamics simulations of noble gases encapsulated in C60 Fullerene

Molecular dynamics simulations of Helium (He), Neon (Ne), Argon (Ar), Krpton (Kr) and Xenon (Xe) encapsulated in C60 are discussed, as well simulations of Fullerenes containing anywhere from two to four He atoms. Even for single atom encapsulates, no species resides at the geometric center of the Fullerene cage. Smaller atoms sit more off-center than larger ones, and He appears to be a special case in both centering and dynamics. Some encapsulated species stabilize the cage by stifling radial fluctuations and others disrupt it; adding Ne seems to have the most stabilizing effect, while Kr and Xe cause the largest radial atomic excursions. Multiple He encapsulates tend to stabilize the cage; such systems are very stressed and show structure over a wide temperature range. Based on dynamical information quadruple He seems to be close to the packing limit for C60.
Thermal Effects of Interfacial Dynamics

Dynamical Ginzburg-Landau theory is applied to the study of thermal effects of motion of interfaces that appear after different phase transitions. These effects stem from the existence of the surface internal energy, entropy and temperature gradients in the interfacial transition region. Evolution equations for the interfacial motion are derived. For the experimental verification of the thermal effects the expression is derived for the amplitude of temperature waves during continuous ordering.
Dormant Intestinal Stem Cells are Regulated by PTEN and Nutritional Status

The cellular and molecular mechanisms underlying adaptive changes to physiological stress within the intestinal epithelium remain poorly understood. Here, we show that PTEN, a negative regulator of the PI3K→AKT→mTORC1-signaling pathway, is an important regulator of dormant intestinal stem cells (d-ISCs). Acute nutrient deprivation leads to transient PTEN phosphorylation within d-ISCs and a corresponding increase in their number. This release of PTEN inhibition renders d-ISCs functionally poised to contribute to the regenerative response during re-feeding via cell-autonomous activation of the PI3K→AKT→mTORC1 pathway. Consistent with its role in mediating cell survival, PTEN is required for d-ISC maintenance at baseline, and intestines lacking PTEN have diminished regenerative capacity after irradiation. Our results highlight a PTEN-dependent mechanism for d-ISC maintenance and further demonstrate the role of d-ISCs in the intestinal response to stress.
Sickle cell hemoglobin: molecular basis of sickling phenomenon theory and therapy.

AbstractThirty years ago, Linus Pauling suggested that sickle cell disease might be due to an abnormal hemoglobin molecule, and I think this was the beginning of molecular medicine. This is what he said about it in his Harvey Lecture69a which he delivered in 1953
Experimental Comparison of Vehicle Vibration Simulation Techniques

Performing accurate vehicle vibration simulation is imperative to understanding the adequacy of a packaged product's ability to withstand the rigors of transportation. Over the past decade, various vehicle vibration analysis techniques were proposed in order to provide better correlation to actual field shipments. This paper highlighted the observations made when an independent laboratory utilized four different methods in the simulation of vertical vibration and applied them to three different packaged products. A field data recorder was employed to record over-the-road vibration of a fully loaded steel spring truck traveling over interstates and highways. The collected data was analyzed independently using each of the different techniques and simulated in a lab with the necessary controller. This study is unique in that it considered the response of actual packaged products and through the use of a damage assessment tool, determined how well the techniques correlate with field vibration results. Additionally, two common industry vibration profiles were used to test the packaged products for comparison. The three packaged products used for these evaluations were a top-mount refrigerator, an electric hedge trimmer, and a gas-powered pressure washer. Results indicate that each of the proposed vehicle vibration analysis techniques produces product and package damage that correlates well with typical field vibration results for the three products tested. These results supported the further use of any of these techniques in the simulation of vehicle vibration.
Local–Global Upscaling for Compositional Subsurface Flow Simulation

Compositional flow simulation is required for the modeling of many important subsurface processes including enhanced oil recovery and geological carbon storage. These simulations can be very demanding computationally, which motivates the need for efficient alternatives to detailed fine-scale flow modeling. In this work, a local–global upscaling procedure for oil–gas compositional problems is developed. With this approach, the key upscaling computations are performed over local (rather than global) fine-scale regions. The pressure boundary conditions required for these computations are determined through an approximate global coarse-scale simulation. Gas saturation and component molar fraction boundary conditions are prescribed based on the injected fluid conditions. An ‘attribute-based’ approach, which enables the efficient assignment of coarse-scale relative permeabilities and compositional functions based on quickly computed (static and single-phase flow) features, is introduced. Numerical results are presented for two- and three-dimensional models (containing eight and four components, respectively) with flow driven by wells. These results demonstrate that the local–global upscaling method, with or without the attribute-based property assignment, provides significantly more accurate predictions than standard (single-phase-parameter) upscaling methods, though accuracy is not as high as that achieved using more expensive global compositional upscaling. Speedups of about an order of magnitude, relative to fine-scale simulations, are observed using the attribute-based local–global procedure. The robustness of the upscaled models to variation in well bottom-hole pressures is also assessed. These computations demonstrate that the upscaled models retain accuracy over a range of well settings, which suggests that they will be useful in computationally demanding applications such as well control optimization.
In vivo increase of the human lens equatorial diameter during accommodation.

The movement of the human lens equator during accommodation was examined in vivo. High-resolution ultrasound images of the lens equator were obtained from young human subjects whose amplitude of accommodation was controlled with 1% tropicamide and 2% pilocarpine. To avoid errors that otherwise arise from eye rotation or other movement, the cornea and sclera were used as positional references in comparative studies of the video images obtained from the unaccommodated and accommodated states. During accommodation, the movement at the lens equator involved small displacement; i.e., < 100 microns, and the equator did not move anteriorly or posteriorly but peripherally toward the sclera. These results indicate that the lens equator is under increased zonular tension during accommodation, in contradiction to Helmholtz's widely accepted theory of accommodation.
NMR Detection of a Delocalized Carbanion Intermediate in the Transamination Reactions of the Metal Chelates of Schiff Bases of Vitamin B6

Studies of the stabilization of the α, α′ a1 deprotonated Schiff base proposed as the intermediate in vitamin B6-catalyzed transamination of α-amino and α-keto acids, previously reported for the interconversion of alanine and pyruvic acid, are now extended to valine, phenylglycine, a-aminoisobutyric acid, and a-ketobutyric acid as substrates, and to N-methylpyridoxal as catalyst.
Empirical Analysis of Interdependency and Volatility among Asian Stock Markets

This paper presents an integrated time series model to analyze the interdependence and volatility among five major Asian stock markets, including Taiwan, Hong Kong, Korea, Singapore, and Japan. The model accounts for autoregression, cross correlation, error correction term, and GARCH effect. The evidence indicates that these five Asian stock markets follow at least one common stochastic trend. The stock returns for four of these Asian markets are contemporaneously correlated with those of Japan, while their correlations with the US stock returns take a one-day lag. Our evidence also shows some dynamic adjustment involving an error correcting process. Finally, the GARCH effect is present in all of the variance equations although we fail to find the GARCH-in-mean supported by the data.
Exploring Patterns of Identity Usage in Tweets: A New Problem, Solution and Case Study

Sociologists have long been interested in the ways that identities, or labels for people, are created, used and applied across various social contexts. The present work makes two contributions to the study of identity, in particular the study of identity in text. We first consider the following novel NLP task: given a set of text data (here, from Twitter), label each word in the text as being representative of a (possibly multi-word) identity. To address this task, we develop a comprehensive feature set that leverages several avenues of recent NLP work on Twitter and use these features to train a supervised classifier. Our model outperforms a surprisingly strong rule-based baseline by 33%. We then use our model for a case study, applying it to a large corpora of Twitter data from users who actively discussed the Eric Garner and Michael Brown cases. Among other findings, we observe that the identities used by individuals differ in interesting ways based on social context measures derived from census data.
Identity, Critical Agency, and Engineering: An Affective Model for Predicting Engineering as a Career Choice

Background Prior to college, many students have no experience with engineering, but some ultimately choose an engineering career. Women choose engineering at lower rates than men. This article uses critical engineering agency (CEA) to understand first-year students' attitudes and self-beliefs to predict the choice of an engineering career. Purpose/Hypothesis We investigated how first-year students' math and physics identities and students' beliefs about the ability of science to improve the world predict choice of engineering as a career and whether these beliefs differ by gender. Design/Method The data were from the Sustainability and Gender in Engineering survey distributed during fall 2011 (N = 6,772). Structural equation modeling was used to understand first-year students' affective beliefs for predicting engineering career choice. Results Math and physics identities are important for predicting engineering choice at the beginning of college. Recognition from others and interest in a subject are positive predictors of physics and math identities. Students' performance/competence beliefs alone are negative predictors of engineering career choice but are mediated by interest and recognition from others. Student identities and agency beliefs are significant predictors of engineering career choice, explaining 20% of the variance. We also found gender differences in students' math and physics identities and agency beliefs. Conclusions This article emphasizes the importance of students' recognition beliefs and the importance of agency beliefs for women in predicting engineering career choice.
Relationship between delayed cardioprotection effect of 11,12-EET and phosphorylated ERK during ischemia and reperfusion in the rat myocardium

AIM: In order to study the relationship of the activation of ERK and delayed cardioprotection of 11,12-EET.METHODS: A rat ischemia/reperfusion(I/R) model was replicated by ligating left anterior descending coronary artery 30 min followed by 60 min.The expression of ERK was detected with Western blotting,and the change of heart function during reperfusion was observed.RESULTS: The difference of myocardial function was prominent at (24 h) in I/R group compared with sham group,EET+I/R and EET+PD098059+I/R group.The activity of ERK at(24 h) in EET+I/R group was higher than sham group, and the activity of ERK in EET+PD098059+I/R group was lower than that in EET+(I/R) group;the expression of phosphorylated ERK1/ERK2 at(24 h) in EET+I/R group was more than that in I/R group,and the expression of phosphorylated ERK1/ERK2 in EET+PD098059+I/R group was less than EET+I/R group.CONCLUSION: 11,12-EET has a delayed cardioprotection effect,and this protection effect is involved in the activity of ERK and expression of phosphorylated ERK1/ERK2.
A New Understanding of Man’s Best Friend: A Proposed Contextual Model for the Exploration of Human–Animal Interaction Among Insecurely Attached Males

My own (Chris Blazina) interest in the bond between man and dog is longstanding, tracing its origins to my youth. When my family’s little house was filled with ten or more people, and felt particularly cramped, I would take a seat on the back steps and talk things over with our gentle German shepherd.
Decitabine Is Effective In Patients with Myelodysplastic Syndromes Who Failed Prior Intensive Regimen: No Negative Impact of Prior Therapy

Abstract 2936 Background: Decitabine is a hypomethylating agent (HMA) with demonstrated activity and an acceptable safety profile for the treatment of all FAB subtypes of myelodysplastic syndromes (MDS). A retrospective analysis was conducted to determine the effect of prior MDS treatment on overall response rate (ORR), duration of response, time to response, and overall survival (OS). Methods: Of 188 patients, 54 had prior MDS treatment consisting of cytotoxic chemotherapy (n=31), immunomodulators (n=21), stem cell transplant (n=4), monoclonal antibodies (n=2), oblimersen (n=1), or HMAs (n=1) were identified from two clinical trials with decitabine (Phase III, 3-day and Phase II, 5-day dosing studies). Patients were stratified on the basis of those who had received prior treatment (PT, n=54) for MDS and those who had not (NPT, n=134). Descriptive statistics were used to quantify the differences between the two groups for baseline characteristics, response rates (based on IWG 2006 criteria), safety and survival data. Results: Baseline characteristics showed the PT group had a longer time from diagnosis; the NPT group had a greater percentage of patients with High risk and Int-2 IPSS scores. There were differences noted in the baseline NPT group (5-day dosing only), with more patients with FAB classification of RAEB and RAEB-t (n=45), whereas the baseline PT group had a greater number of CMML patients (n=8). Objective response rate (ORR), overall improvement rate (OIR) and median survival were greater in NPT patients with no significant difference observed between the groups (Table 1). Patients with PT had a shorter duration of improvement (median 208 days) vs. the NPT group (median 296 days, p=NS) for the 5-day dosing study. Conclusions: Decitabine is active in patients with MDS with low rate of side effects. Prior therapy with intensive regimens have no impact on response to decitabine and such patients should be considered for hypomethylating therapy. Disclosures: Jabbour: Eisai Inc.: Editorial and statistical support, Honoraria. Kantarjian: Novartis: Research Funding; Pfizer: Research Funding; Bristol Myers Squibb: Research Funding; Novartis: Consultancy. Borthakur: Eisai Inc.: Research Funding. Cortes: Novartis: Research Funding; Pfizer: Consultancy, Research Funding; Bristol Myers Squibb: Research Funding. Ravandi: Eisai Inc.: Research Funding; Eisai Inc.: Honoraria.
Rituximab, Bevacizumab (Avastin) and CHOP (RA-CHOP) for Patients with Diffuse Large B-Cell Lymphoma (DLBCL).

Abstract Introduction Bevacizumab is a humanized monoclonal antibody directed against vascular endothelial growth factor (VEGF). Non-Hodgkin's lymphoma (NHL) patients with a high serum VEGF levels have an inferior overall survival compared to patients with low VEGF levels. Rituximab plus CHOP (R-CHOP) prolongs time to treatment failure and survival in patients with DLBCL. But further improvement is needed, particularly with patients with high-intermediate and high risk international index disease. This study was designed to assess the feasibility of the combination of bevacizumab plus R-CHOP (RA-CHOP). Method Bevacizumab was administered at 15 mg/kg IV on day 1 of each cycle over 30–90 minutes. R-CHOP was administered on day 2 of cycle 1 and on day 1 of subsequent cycles. Patients were monitored for cardiac function with echocardiogram and for proteinuria. Serum levels of bevacizumab and rituximab were measured to assess pharmacokinetics. Serum and urine samples were also analyzed for circulating VEGF. Tumor samples were stained for VEGF by immunohistochemistry. Results Twelve patients (10 males, and 2 females) with newly-diagnosed DLBCL were enrolled. The median age was 48 years (range 29–63). Three patients had stage II primary mediastinal, 2 stage III, and 7 stage IV disease. ECOG performance status ranged from 0–1. Nine patients had an elevated LDH with a median international index score of 2 (range 0–3). Nine patients had an international index score of 2–3. A total of 80 cycles (range 2–8; median 7) of RA-CHOP was administered. Bevacizumab was held in 5 cycles in 3 patients-due to 1) elevated liver enzymes in the setting of positive hepatitis C serology, 2) transient proteinuria, and 3) DVT associated with central line. The following grade 3 toxicities were observed: 4 febrile neutropenia with infection related to central line, 2 DVT (both central line associated), 1 elevated liver enzymes, and 2 transient hypertension. Grade 4 toxicities included 3 absolute neutropenia with 2 febrile neutropenia, and 1 HSV esophagitis. Two patients are too early to assess response. Best response included CR in 3, PR in 4 (2 with normal PET scans), SD in 1. One patient progressed and another achieved a PR after 4 cycles but further treatment was not given due to severe depression. Conclusion In this patient population, treatment with RA-CHOP did not result in any grade 3 or 4 proteinuria, heart failure or bleeding. Hypertension was transient and thrombosis was associated with central line placement. Correlative studies and pharmacokinetics are being analyzed and will be available for presentation.
Evaluation of health information systems research in information systems research: A meta-analysis.

Given the importance of the health-care industry and the promise of health information systems, researchers are encouraged to build on the shoulders of giants as the saying goes. The health informa...
Phase I Trial of Intravenous Oncolytic Vaccinia Virus (GL-ONC1) with Cisplatin and Radiotherapy in Patients with Locoregionally Advanced Head and Neck Carcinoma

Purpose: Preclinical models have shown that the effectiveness of GL-ONC1, a modified oncolytic vaccinia virus, is enhanced by radiation and chemotherapy. The purpose of this study was to determine the safety of GL-ONC1 when delivered intravenously with chemoradiotherapy to patients with primary, nonmetastatic head and neck cancer.Experimental Design: Patients with locoregionally advanced unresected, nonmetastatic carcinoma of the head/neck, excluding stage III-IVA p16-positive oropharyngeal cancers, were treated with escalating doses and cycles of intravenous GL-ONC1, along with radiotherapy and chemotherapy. The primary aims were to define the MTD and dose-limiting toxicities, and to recommend a dose for phase II trials.Results: Between May 2012 and December 2014, 19 patients were enrolled. The most frequent adverse reactions included grade 1-2 rigors, fever, fatigue, and rash. Grade 3 adverse reactions included hypotension, mucositis, nausea, and vomiting. In 2 patients, the rash was confirmed as viral in origin by fluorescence imaging and viral plaque assay. In 4 patients, viral presence in tumor was confirmed on midtreatment biopsy by quantitative PCR. In 1 patient, live virus was confirmed in a tongue tumor 7 days after receiving the first dose of virus. The MTD was not reached. With median follow-up of 30 months, 1-year (2-year) progression-free survival and overall survival were 74.4% (64.1%) and 84.6% (69.2%), respectively.Conclusions: Delivery of GL-ONC1 is safe and feasible in patients with locoregionally advanced head/neck cancer undergoing standard chemoradiotherapy. A phase II study is warranted to further investigate this novel treatment strategy. Clin Cancer Res; 23(19); 5696-702. ©2017 AACR.
Calling Inspector Gadget [Microwave Surfing]

Unless you were away earlier this year on an intergalactic mission, you probably picked up the heavy media buzz around the claim [1] made by an “important government source”: There was an article this week that talked about how you can surveil someone through their phones, through their . . . certainly through their television sets, any number of different ways. And microwaves that turn into cameras, et cetera. So we know that that is just a fact of modern life. So: is it really a fact of modern life that microwaves can spy on you? It depends on the meaning of microwaves. According to the Merriam-Webster Online Dictionary [2], the word means either “a comparatively short electromagnetic wave; especially: one between about one millimeter and one meter in wavelength” or a “microwave oven.”
The impact of adaptive guards for 5G and beyond

The next generation communication systems are evolving towards an increased flexibility in different aspects. Enhanced flexibility is the key in order to address diverse requirements. This paper presents the significance of adaptive guards considering a windowed-OFDM system which supports a variety of services operating asynchronously under the same network. The windowing approach requires a guard duration to suppress the out-ofband emissions (OOBE), and the guard band is required to handle the adjacent channel interference (ACI) along with the windowing. The guards in both time and frequency domains are optimized with respect to the use case and power offset between the users. To fully exploit and further increase the potential of adaptive guards, an interference-based scheduling algorithm is proposed as well. The results show that the precise design that facilitates such flexibility reduce the guards significantly and boost the spectral efficiency.
Putting Feelings Into Words: Affect Labeling as Implicit Emotion Regulation

Putting feelings into words, or “affect labeling,” can attenuate our emotional experiences. However, unlike explicit emotion regulation techniques, affect labeling may not even feel like a regulatory process as it occurs. Nevertheless, research investigating affect labeling has found it produces a pattern of effects like those seen during explicit emotion regulation, suggesting affect labeling is a form of implicit emotion regulation. In this review, we will outline research on affect labeling, comparing it to reappraisal, a form of explicit emotion regulation, along four major domains of effects—experiential, autonomic, neural, and behavioral—that establish it as a form of implicit emotion regulation. This review will then speculate on possible mechanisms driving affect labeling effects and other remaining unanswered questions.
Early outcomes in transoral vestibular thyroidectomy: Robotic versus endoscopic techniques.

Background The transoral thyroidectomy vestibular approach has been utilized via both robotic (TORTVA) and endoscopic (TOETVA) techniques to perform thyroidectomy. However, there have been no studies evaluating outcomes between these approaches. Here we describe our outcomes for thyroid lobectomy with TORTVA and TOETVA. Methods All cases of transoral vestibular approach thyroid lobectomy at Johns Hopkins Hospital were reviewed. Primary outcomes and demographic data were then compared between TORTVA and TOETVA. Results Twenty-seven cases were identified, 7 using the robotic approach and 20 using the endoscopic approach. The procedural success rate for the robotic and endoscopic cohorts was 5 of 7 (71%) and 19 of 20 (95%), respectively (P = .15). There were no persistent nerve injuries, mental, or recurrent in either cohort. Median operative time for TOETVA was 188 minutes versus 322 minutes for TORTVA (P = .001). Conclusion Thyroid lobectomy can be safely performed via both techniques, although performed more quickly endoscopically, which is likely due in part to differences in the learning curves.
Light-Induced Acceleration of Photoreceptor Degeneration in Transgenic Mice Expressing Mutant Rhodopsin

Results. Retinas of normal animals, whether reared in darkness or in cyclic light, had no structural or functional abnormalities. The rate of photoreceptor degeneration in darkreared transgenic mice was significantly slower than in transgenic mice raised under cyclic light conditions. Differences between the two groups of animals were evident in the retinal histology, the electroretinographically determined sensitivity to photic stimulation, and the rhodopsin levels in the retina. TUNEL labeling of retinal wholemounts showed that cyclic light-reared animals had a threefold higher incidence of photoreceptor cell death than their dark-reared counterparts; the density of apoptotic cells was greatest in the inferior retina, the region most severely affected in patients with the P23H mutation. In comparison, photoreceptor cell death was more uniformly distributed across the retina in dark-reared transgenic mice. Conclusions. These findings suggest that light activation of rhodopsin contributes to the severity of the degenerative disease resulting from the P23H opsin mutation, and they raise the possibility that minimizing exposure to light may help to prolong useful vision of patients with this form of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1996; 37:775-782.
The Role of Public Argument in Emerging Democracies: A Case Study of the 12 December 1993 Elections in the Russian Federation

The authors argue that in the 1993 Duma elections it was the Communist Party of the Russian Federation, led by Gennady Zyuganov, that incorporated rhetorical values and audience adaptation into its campaign strategy. Finding its discursive ground limited by history, the CPRF gradually shifted its rhetorical posture and argumentative strategies, redefining itself in the process. This evolution allowed the CPRF to employ the ideographs of ’democracy‘, ‘will of the people‘, ’citizen‘, and other key terms of Western-style democracy, while retaining, albeit in transformed meaning, traditional communist ideographs such as ’justice‘ and ’spirituality‘. In addition, the CPRF was able to borrow selectively from the history of the USSR between 1917 and 1989, thereby imbuing their political appeals with historical force and cultural memory.
On Defending The Covering-Law “Model”

Hempel in Aspects of Scientific Explanation and Other Essays tells us that “all scientific explanation involves, explicitly or by implication, a sub-sumption of its subject matter under general regularities; that it seeks to provide a systematic understanding of empirical phenomena by showing that they fit into a nomic nexus.”1 This I take to be an informal statement of his covering-law “model” of scientific explanation. In defense of his “model” against apparent examples of scientific explanations which do not fit it, Hempel’s almost instinctive reaction has been to patch them up in some way so that they do conform. This, I believe, is the wrong way to defend the covering-law “model”. In the three parts of this brief essay I shall do the following: (1) show that Hempel’s attempt to patch up a certain version of so-called “rational” explanation does not succeed of its purpose, (2) generalize that result with respect to all dispositional explanations, and (3) reflect momentarily on philosophic method and another way to defend the covering-law “model”.
The Cray Research MPP Fortran Programming Model

An integral part of any computer system is the programming model because most users program with high level languages. Programming model definition for massively parallel systems is an important research area. In their current Fortran product, Cray Research, Inc. has defined a Fortran based programming model that allows programmers to specify both explicit and implicit communication in a parallel program. The explicit communication is available through a message passing library that supports both a standard interface for sending and receiving data, and low level primitives that directly exploit addressing features available in the target machine, the Cray T3D® system. The implicit communication is available through language features called data sharing and work sharing. The data sharing and work sharing features are available through a set of directives that can be added to existing programs. There is also implied work sharing available through the use of array syntax statements involving shared data. There are other directives and intrinsic functions that provide access to explicit synchronization. One unique quality of this model is that both implicit and explicit communication styles can be combined within the same program.
The Haunting Letter: Presence, Absence, and Writing in Sab

Written expression allows for communication across absences both spatial and temporal. In fact, Jacques Derrida argues in his essay “Signature Event Context” (1988) that absence is an element of every communication and, because of this absence, meaning shifts with new contexts and displacements. When the titular character of Gertrudis Gomez de Avellaneda’s 1841 Cuban-Spanish Gothic novel Sab – a black slave in love with his white mistress – dies immediately after finishing a letter, he imbues the writing with his presence by way of his first-person expression and personal narrative, while simultaneously ensuring his irreversible absence from his text by death. That his letter outlives him allows for the reiteration of Sab’s final words and thoughts each time his letter is reread. This play between absence and presence inherent in Sab’s letter is the same essential paradox of the specter as described by Derrida in Specters of Marx (1993). Sab’s combined presence and absence in his letter turns him into a kind of ghost that haunts those who read his words.In this paper, I analyze Sab’s letter and its rippling effect throughout the story. The letter acts to identify Sab — and through him the institution of slavery that he both represents and protests against — as the haunting figure of the novel. This haunting, by its very existence, critiques the remembrance of history.