cssi/SciSciGPT-SciSciNet huggingface dataset:
Development and validation of the avoidance of environmental tobacco smoke scale.

The Avoidance of Environmental Tobacco Smoke (ETS) scale is a self-report measure of the avoidance of ETS by young adults. Initial use of the scale with 30 undergraduate students showed an internal consistency of .84 across 40 items and .90 in a refined 28-item instrument. In a sample of 241 students, a 20-item scale had an internal consistency reliability of .94 and a refined 10-item scale had an internal consistency of .86. In a sample of 95 mothers with a mean age of 36, the 10-item scale had an internal consistency of .81. In three distinct samples, significant known groups' discrimination was found between smokers and nonsmokers. Psychometric analysis indicates that the scale merits further testing using a more heterogeneous sample from community and clinical populations to ensure its usefulness by clinicians and researchers interested in explaining, predicting, and preventing exposure to ETS.
Endometriosis with massive bloody ascites.

Endometriosis is commonly found in 10 to 15 percent of women aged between 25 and 44 years,! and it has been estimated that 25 to 40 percent of infertile women have endometriosis.! In this report, we describe a patient with endometriosis whose signs were massive bloody ascites. The purpose of this report is to increase awareness among physicians of the varied clinical manifestations of intestinal endometriosis.
Clinical Risk Prediction Tools for Prostate Cancer: TNM to CAPRA—Should Risk Be Redefined?

Variation in prostate cancer biology and outcomes warrants highly calibrated assessment instruments that allow for reliable risk estimation at relevant decision points. In this chapter, we provide a critical overview of the principles by which risk stratification tools are evaluated as well as a longitudinal contextualization of clinical prognostication. Risk groupings including the D’Amico, AUA, and NCCN classification systems derived from categorical clinical characteristics including PSA, Gleason score, and clinical stage offer a parsimonious framework that can be recalled with relative ease, yet demonstrate suboptimal discrimination due to very wide heterogeneity within groups. Nomograms derived from multivariate models offer improvements in spectrum bias and discrimination by incorporating continuous variables accounting for a wide range of values, rather than dichotomized groupings, and however face limitations in the requirement of multi-step drawing or online calculator.
Wall suction-assisted image-guided therapeutic paracentesis: a safe and less expensive alternative to evacuated bottles

To assess the safety and cost savings of using wall suction and plastic canisters instead of evacuated bottles, currently in short supply, to drain, and collect large amounts of fluid during image-guided paracentesis procedures. In a hospital-based practice, 551 image-guided paracenteses were performed in 191 consecutive patients over a 10-month period, using wall suction to facilitate drainage. Total volume of fluid removed and complications were recorded. Complications were graded using Common Terminology Criteria for Adverse Events. The pressure generated from the wall suction at our institution was measured using a manometer and compared to that of an empty evacuated bottle. Cost savings per procedure were estimated by calculating the difference in the price of supplies used to collect the average volume of fluid removed per procedure for each method. The mean volume of fluid removed per procedure was 3541 mL. Four (0.72%) complications occurred in 551 procedures. One grade I complication consisted of a prolonged puncture site leak of ascites. Three Grade III complications included infection, hypotension, and atrial fibrillation. All four complications appeared unrelated to the use of wall suction and were treated successfully. Maximum pressure generated from the wall suction at our institution was less than the initial pressure generated from an empty evacuated bottle. Estimated cost savings per procedure was $33.92. The use of wall suction and plastic canisters to drain and collect fluid during image-guided therapeutic paracenteses is a safe alternative to using evacuated glass bottles and reduces per-procedure costs.
HIV-1 transgenic rat: Altered motivated behavior for natural reward

s / Drug and Alcohol Dependence 146 (2015) e202–e284 e223 HIV-1 transgenic rat: Altered motivated behavior for natural reward Sarah J. Bertrand, Charles F. Mactutus, Steven B. Harrod, Amanda J. Morgan, Rosemarie M. Booze Psychology, University of South Carolina, Columbia,
Development of a novel sports medicine rotation for emergency medicine residents.

Musculoskeletal complaints are the most common reason for patients to visit a physician, yet competency in musculoskeletal medicine is invariably reported as a deficiency in medical education in the USA. Sports medicine clinical rotations improve both medical students’ and residents’ musculoskeletal knowledge. Despite the importance of this knowledge, a standardized sports medicine curriculum in emergency medicine (EM) does not exist. Hence, we developed a novel sports medicine rotation for EM residents to improve their musculoskeletal educational experience and to improve their knowledge in musculoskeletal medicine by teaching the evaluation and management of many common musculoskeletal disorders and injuries that are encountered in the emergency department. The University of Arizona has two distinct EM residency programs, South Campus (SC) and University Campus (UC). The UC curriculum includes a traditional 4-week orthopedic rotation, which consistently rated poorly on evaluations by residents. Therefore, with the initiation of a new EM residency at SC, we replaced the standard orthopedic rotation with a novel sports medicine rotation for EM interns. This rotation includes attendance at sports medicine clinics with primary care and orthopedic sports medicine physicians, involvement in sport event coverage, assigned reading materials, didactic experiences, and an on-call schedule to assist with reductions in the emergency department. We analyzed postrotation surveys completed by residents, postrotation evaluations of the residents completed by primary care sports medicine faculty and orthopedic chief residents, as well as the total number of dislocation reductions performed by each graduating resident at both programs over the last 5 years. While all residents in both programs exceeded the ten dislocation reductions required for graduation, residents on the sports medicine rotation had a statistically significant higher rate of satisfaction of their educational experience when compared to the traditional orthopedics rotation. All SC residents successfully completed their sports medicine rotation, had completed postrotation evaluations by attending physicians, and had no duty hour violations while on sports medicine. In our experience, a sports medicine rotation is an effective alternative to the traditional orthopedics rotation for EM residents.
The Clinical Pathologic-CT Comparative Analysis on 15 Cases of Solitary Fibrous Tumor

Solitary fibrous tumor(SFT)is one of the rare entities of soft tissue tumors.The aim of this paper is to make comparative study on the clinical CT and pathological characteristics of solitary fibrous rumors (SFTs) and summarize our experience in the diagnosis of SFTs with CT.Methods:Fifteen cases of biopsy-or surgery-confirmed SFTs were studied using CT and the histopathological and immunohistochemical techniques.The clinic-pathologic and CT scan data of 15 cases were collected. The imaging features on CT were analyzed and the differential diagnoses were assessed.Immunohistochemical staining for CD34, vimentin,CD99,bcl-2,S-100,SMA,EMA was performed in all cases.Results:The 7 male and 8 female patients were from 31 to 73 years old,with an average age of 48 years at the time of diagnosis.Their SFTs were located in thoracic cavity (6/15,with 3/7 in lungs,3/7 in pleura),nasal cavity(2/15),maxillary sinus (1/15),abdominal cavity(1/15),parapharyngeal space(1/15),parofid salivary gland(1/15),kidney(1/15),fossa iliaca(1/15)and fossa orbitalis (1/15).The results showed 91.6% of positive staining for CD34,100% of positive Vim(vimentin)and 87.5% of positive Bcl-2 express.The main dirlical manifestations were local mass and pressure symptoms.The characteristic microscopic features included pattern-less growth pattern,altemating hyper-and hypo- cellular areas,blunt spindle cells with in keloidlike hyalinization,and hemangiopericytoma-like regions.The CT scan showed well- defined margins and smooth contours,homogeneous attenuation.Contrast enhanced CT showed early intense enhancement as a result of the rich vascularization.Homogeneous and geographic pattern contrast enhancement of the lesions in the early stage is the main feature.Conclusions:SFF is the soft tumors with well-defined margins and smooth contours.Due to the myxoid degeneration or hemorrhage,the homogeneous attenuation and homogeneous or geographic pattern contrast enhancement are the most typical features.
Barbiturate AEDS, EEG and Cognitive Performance

Neuropsychological performance and quantitative EEGs were studied in 11 epileptic children, aged 7 to 14 years, both during treatment and without phenobarbital and mephobarbital, and in comparison to 13 matched controls, at Tulane University Medical School, New Orleans, LA.
Model Studies of Chemical Vapor Deposition

Chemical vapor deposition (CVD) is a widely used method for depositing thin films with applications ranging from the fabrication of microelectronic devices to the deposition of protective coatings. Sandia has a coordinated program of experimental and theoretical research that has advanced the scientific understanding of CVD processes. Numerical simulations of CVD processes based on such an understanding should lead to faster equipment design and process development in the future.
What Kinds of School Content and School Contexts Link

In this chapter the final teacher, Mrs. Wilson , is introduced. Mrs. Wilson ’s students participated in studies for two years. These students participated in expository writing projects on the animals of the rainforest and sea mammals. This classroom provided the prompt to begin looking at links that students made with experiences that took place in school. These school-developed links allowed students to link across school years, across different content areas, and across activities that explored the content in different ways. The links that were prominent from the students, rather than those that the teachers made, were those that the students made with the activities in which they engaged in the class, rather than the teacher merely telling the students about the content.
The Inflammatory Subset of Monocytes Stimulates Angiogenesis at Sites of Ischemia by Altering the Balance of Pro- and Anti-Inflammatory Cytokines.

Our laboratory has previously shown that early delivery of monocytes to ischemic tissue by mobilization from the bone marrow to blood or by adoptive transfer enhances revascularization after acute vascular injury. There is accumulating evidence that monocytes represent a heterogeneous population, containing subsets with distinct functional properties. Herein, we show that the inflammatory subset of monocytes mediates the angiogenic response in a murine model of hindlimb ischemia induced by femoral artery excision (FAE). Inflammatory (CX3CR1loGr-1+) and resident (CX3CR1hiGr-1−) monocytes were sorted from the bone marrow of CX3CR1+/GFP mice and injected intravenously into recipient mice 24 after FAE. Revascularization was monitored by laser Doppler imaging. A marked improvement in blood flow was observed after adoptive transfer of inflammatory but not resident monocytes [ratio of blood flow in ischemic to nonischemic limb 7 days after surgery: 0.75±0.05 (inflammatory monocytes); 0.40±0.07 (resident monocytes); 0.40±0.03 (saline control); P <0.01]. Consistent with this finding, inflammatory monocytes are selectively recruited to sites of ischemia. Finally, we show that the bone marrow is a rich reservoir of inflammatory monocytes that is readily mobilized into the blood by ischemia. To begin to elucidate the mechanisms by which inflammatory monocytes stimulate angiogenesis, we determined the effect of the adoptive transfer of monocytes on the local production of key cytokines/chemokines in the ischemic tissue. Specifically, a non-biased multiplex immunoassay-based screen for soluble factors present in the cell-free muscle homogenates was performed. Data revealed decreased levels of the pro-inflammatory cytokines IL-6, KC, and mip-1beta and increased levels of the anti-inflammatory cytokine IL-10 in mice receiving an adoptive transfer of monocytes. In keeping with this observation, levels of free myoglobin were dramatically decreased in mice receiving an adoptive transfer of monocytes, indicating a reduction in inflammation-mediated tissue damage [myoglobin levels at 28 hours post-ischemia: 18,580±879 ng/mL (no adoptive transfer); 158±112 ng/mL (adoptive transfer)]. Interestingly, known regulators of angiogenesis, MCP-1, MMP-9, VEGF, and FGF-basic were also significantly increased. Taken together, these data indicate that adoptive transfer of a small number of monocytes shifts the balance of pro- and anti-inflammatory signals in the ischemic environment, which limits tissue damage and enhances revascularization. This finding has important therapeutic implications, since deliver of inflammatory monocytes to sites of ischemia may polarize the microenviroment towards tissue regeneration and angiogenesis.
Development of an autonomous treatment planning strategy for radiation therapy with effective use of population-based prior data.

PURPOSE Current treatment planning remains a costly and labor intensive procedure and requires multiple trial-and-error adjustments of system parameters such as the weighting factors and prescriptions. The purpose of this work is to develop an autonomous treatment planning strategy with effective use of prior knowledge and in a clinically realistic treatment planning platform to facilitate radiation therapy workflow. METHOD Our technique consists of three major components: (i) a clinical treatment planning system (TPS); (ii) a formulation of decision-function constructed using an assemble of prior treatment plans; (iii) a plan evaluator or decision-function and an outer-loop optimization independent of the clinical TPS to assess the TPS-generated plan and to drive the search toward a solution optimizing the decision-function. Microsoft (MS) Visual Studio Coded UI is applied to record some common planner-TPS interactions as subroutines for querying and interacting with the TPS. These subroutines are called back in the outer-loop optimization program to navigate the plan selection process through the solution space iteratively. The utility of the approach is demonstrated by using clinical prostate and head-and-neck cases. RESULTS An autonomous treatment planning technique with effective use of an assemble of prior treatment plans is developed to automatically maneuver the clinical treatment planning process in the platform of a commercial TPS. The process mimics the decision-making process of a human planner and provides a clinically sensible treatment plan automatically, thus reducing/eliminating the tedious manual trial-and-errors of treatment planning. It is found that the prostate and head-and-neck treatment plans generated using the approach compare favorably with that used for the patients' actual treatments. CONCLUSIONS Clinical inverse treatment planning process can be automated effectively with the guidance of an assemble of prior treatment plans. The approach has the potential to significantly improve the radiation therapy workflow.
Restoring surface fire stabilizes forest carbon under extreme fire weather in the Sierra Nevada

Climate change in the western United States has increased the frequency of extreme fire weather events and is projected to increase the area burned by wildfire in the coming decades. This changing fire regime, coupled with increased high-severity fire risk from a legacy of fire exclusion, could destabilize forest carbon (C), decrease net ecosystem exchange (NEE), and consequently reduce the ability of forests to regulate climate through C sequestration. While management options for minimizing the risk of high-severity fire exist, little is known about the longer-term carbon consequences of these actions in the context of continued extreme fire weather events. Our goal was to compare the impacts of extreme wildfire events on carbon stocks and fluxes in a watershed in the Sierra National Forest. We ran simulations to model wildfire under contemporary and extreme fire weather conditions, and test how three management scenarios (no-management, thin-only, thin and maintenance burning) influence fire severity, forest C stocks and fluxes, and wildfire C emissions. We found that the effects of treatment on wildfire under contemporary fire weather were minimal, and management conferred neither significant reduction in fire severity nor increases in C stocks. However, under extreme fire weather, the thin and maintenance burning scenario decreased mean fire severity by 25%, showed significantly greater C stability, and unlike the no-management and thin-only management options, the thin and maintenance burning scenario showed no decrease in NEE relative to the contemporary fire weather scenarios. Further, under extreme fire weather conditions, wildfire C emissions were lowest in the thin and maintenance burning scenario, (reduction of 13.7 Mg C/ha over the simulation period) even when taking into account the C costs associated with prescribed burning. Including prescribed burning in thinning operations may be critical to maintaining C stocks and reducing C emissions in the future where extreme fire weather events are more frequent.
Implementation of an enhanced recovery protocol in pediatric colorectal surgery

Abstract Purpose Enhanced recovery protocols (ERPs) have been shown to improve outcomes in adult surgical populations. Our purpose was to compare outcomes before and after implementation of an ERP in children undergoing elective colorectal surgery. Methods A pediatric-specific colorectal ERP was developed and implemented at a single center starting in January 2015. A retrospective review was performed including 43 patients in the pre-ERP period (2012–2014) and 36 patients in the post-ERP period (2015–2016). Outcomes of interest included number of ERP interventions received, length of stay (LOS), complications, and readmissions. Results The median number of ERP interventions received per patient increased from 5 to 11 from 2012 to 2016. The median LOS decreased from 5days to 3days in the post-ERP period (p=0.01). We observed a simultaneous decrease in median time to regular diet, mean dose of narcotics, and mean volume of intraoperative fluids (p Conclusions Implementation of a pediatric-specific ERP in children undergoing colorectal surgery is feasible, safe and may lead to improved outcomes. Further experience may highlight other opportunities for increased compliance and improved care. Level of evidence Treatment Study. Level III.
Abstract P197: Reversible Acetylation of GSK3β Regulates the Development of Cardiac Hypertrophy

Glycogen synthase kinase 3β (GSK3β) is a critical regulator of diverse cellular functions involved in the maintenance of cellular structure, function and survival. In the heart, GSK3β has been shown to play a key role in antagonizing the development of cardiac hypertrophy. It has been shown that GSK3β activity is inhibited by phosphorylation at Ser9 during the development of cardiac hypertrophy. However, recent studies indicated that blocking the Ser9 phosphorylation alone is not sufficient to protect GSK3β activity, suggesting that alternative mechanisms might be involved in regulation of GSK3β activity. In the present study, we tested the hypothesis whether GSK3β is acetylated in established hypertrophy, which leads to inhibition of GSK3β activity, and thereby promoting progression and maintenance of cardiac hypertrophy. We examined acetylation, phosphorylation and catalytic activity of GSK3β in pressure overload model of cardiac hypertrophy at different stages of hypertrophy development. The results showed that GSK3β catalytic activity was significantly down-regulated throughout the course of hypertrophy development. However, the inhibitory phosphorylation of GSK3β was observed only at initial stages, but not at later stages of pressure overload (4 weeks). Interestingly, we observed a significantly increased acetylation of GSK3β, which corresponded to the reduced activity at this later stage of hypertrophy. We then determined the impact of GSK3β acetylation on its catalytic activity, by measuring the ability of GSK3β to phosphorylate the substrate glycogen synthase. The results showed that acetylation decreased the catalytic activity of the GSK3β by almost 3 fold. Next, we performed mass spectrometry to find out the target lysine residues of GSK3β. Proteomic analysis revealed that multiple lysine residues in different regions of GSK3β were acetylated. By using site directed mutagenesis, we found that acetylation inhibits the catalytic activity of GSK3β by suppressing its substrate binding ability, which is independent of inhibitory-Ser 9 phosphorylation. These studies for the first time show a phosphorylation independent mechanism regulating GSK3β activity during progression and maintenance of cardiac hypertrophy.
Novel neurobiological properties of elements in the escape circuitry of the shrimp.

ABSTRACT Escape behaviors in penaeid shrimp are mediated by large myelinated medial giant fibers which course from the brain to the last abdominal ganglion in the ventral nerve cord. In each abdominal segment, the medial giant axons make synaptic connections with paired myelinated motor giant axons that excite the abdominal deep flexor muscles and drive the tailflips that constitute the escape behavior. I examined (1) anatomical features of the abdominal motor giant fibers and (2) electrical properties of both the medial and motor giant axons in the pink shrimp, Farfantepenaeus duorarum . The motor giant axons in the paired third roots of shrimp abdominal ganglia emerge from a single fused neurite that originates from two clusters of cell bodies within the ganglion. Injection of large positive currents into the abdominal medial giant fibers generates action potentials that are transmitted to the opposite medial giant axon through putative collateral synapses within the ganglia. Transmission across the medial-to-motor giant synapse is fast and resistant to fatigue, with synaptic delays equal to or less than those previously documented at the lateral-to-motor giant electrical synapse in crayfish. Transmission was found to be extremely reliable even with presynaptic spike frequencies as high as 250 Hz. While action potentials within the medial giant fibers are transmitted across the medial-to-motor giant synapse with a large safety factor, neither prolonged positive nor prolonged negative currents pass through the synaptic nexus, irrespective of the site of injection. The lack of DC current passage along with the inability of neurobiotin or biocytin to spread through the synaptic nexus raises the possibility that the synaptic mechanism may be capacitative.
English Past and English Present: The Phrase “Old English” in Middle English Texts

Examining English texts from the thirteenth through fifteenth centuries that use the phrase “Old English” reveals the writers’ attitudes about older forms of the language. In most instances, they did not intend to identify or define “Old English” but instead, to note its close or distant relationship to the language as they used it themselves, including in contrast to French or Latin. When proverbs are described as “Old English” both age and vernacularity are meant to impress an English-speaking audience. Elsewhere, writers such as William Langland and William Caxton use “Old English” to indicate linguistic archaism, especially of lexicon.
Survivor Objects: Cultural Heritage in and out of the Middle East

Artifacts that have experienced atrocities, even genocide, and survived, acquire the power to recall the horrors of the past, and to recollect the absent persons, things, and places that were lost. They symbolize violence, but also survival and resilience. Material objects that have endured looting, mutilation, displacement, and separation from the communities where they functioned as sacred relics, liturgical aids, or prized artworks form a special category. They are survivor objects.
CROPPING IN AN AGE OF CAPTIVE TAKING: EXPLORING EVIDENCE FOR UNCERTAINTY AND FOOD INSECURITY IN THE SEVENTEENTH-CENTURY NORTH CAROLINA PIEDMONT

Engagement in sustained encounters with colonial actors had long-lasting demographic, social, and political consequences for Native American inhabitants of Southeastern North America during the colonial period (AD 1670–1783). Less clear is whether Native peoples who did not regularly trade with colonists also felt the destabilization experienced by more closely affiliated groups. This article explores Native lifeways in the seventeenth-century Eno River valley of the North Carolina Piedmont, a context for which archaeological and ethnohistoric evidence have produced divergent narratives. While extant archaeological findings suggest that daily life from 1650 to 1680 continued virtually unchanged from the preceding Late Woodland period, ethnohistoric accounts indicate that this area was victimized by Native slavers who abducted countless women and children. Seeking to reconcile these narratives, I conducted a diachronic analysis of botanical remains and architecture. Archaeobotanical data reveal that Jenrette site (AD 1650–1680) occupants adopted foodways that differed significantly from those of their Late Woodland predecessors, while architectural evidence indicates a brief village occupation. I argue that Eno River valley inhabitants introduced risk-averse subsistence practices that would have aided in coping with the threat and consequences of slave raiding and that these practices occurred within a social climate of fear and uncertainty that is documented ethnohistorically.
Assessing intrinsic and specific vulnerability models ability to indicate groundwater vulnerability to groups of similar pesticides: A comparative study.

With continued population growth and increasing use of fresh groundwater resources, protection of this valuable resource is critical. A cost effective means to assess risk of groundwater contaminat...
IMMUNOGLOBULIN G4-RELATED DISEASE MANIFESTING AS CONSTRICTIVE PERICARDITIS

The diagnosis of constrictive pericarditis (CP) often is elusive due to varied causes with nonspecific clinical findings. Conservative management is difficult and surgical pericardiectomy is sometimes required for diagnosis, as well as therapy. A 78-year-old man presented with dyspnea, peripheral
Temporal contiguity in incidentally encoded memories

Abstract Thinking of one event often triggers recall of other events experienced nearby in time. This Temporal Contiguity Effect has been extensively documented in laboratory list learning tasks, but its source is debated. Is it due to task-general automatic processes that operate whenever new memories are formed? Or is it due to task-specific encoding strategies that operate only during deliberate rote learning? I test these theories by presenting over 3500 subjects with a surprise free recall test after various incidental encoding tasks. Experiments 1 and 2 show that temporal contiguity is dramatically reduced under incidental encoding. Experiments 3 and 4 show that although the effect is reduced, it is not eliminated—temporal information is encoded incidentally and is used to guide memory search during both free recall and serial recall. These results demonstrate that contiguity is not an artifact of strategy, but the dramatic reduction of the effect also challenges models that posit a strong link between successful memory encoding and contiguity.
Biochemical and Molecular Biological Characterization of Biotinylated Proteins of Plants

At least six biotinylated polypeptides can be detected in extracts from plants (1). These polypeptides are approximately 240 kDa, 120 kDa, 75 kDa, 60 kDa, 39 kDa and 34 kDa in size. Furthermore, the biotin enzymes, acetyl-CoA carboxylase (ACCase), propionyl-CoA carboxylase (PCCase), methylcrotonyl-CoA carboxylase (MCCase), pyruvate carboxylase (1) and geranoyl-CoA carboxylase (GCCase) are detectable in extracts from plants, We have undertaken biochemical and molecular biological approaches to identify and characterize the enzymes these polypeptides represent.
Functional Magnetic Resonance Imaging in Developmental Psychopathology: The Brain as a Window into the Development and Treatment of Psychopathology

The development of psychopathology results from a complex interplay between genetic and environmental influences over time. The use of functional magnetic resonance imaging (fMRI) allows for the examination of brain function as a potential mediator of these interactions. Throughout the chapter, two applications of fMRI to understanding the development and treatment of psychopathology are discussed. First, fMRI can be used to examine the association between genetic or epigenetic variation and neural function as a means of elucidating the developmental pathways involved in gene x environment interactions on risk for psychopathology. Second, fMRI has applications for the development and testing of novel treatments for psychiatric disorders. Research reviewed focuses on anxiety disorders and autism spectrum disorder as examples to illustrate how the inclusion of fMRI as a level of analysis can advance understanding of the development and treatment of psychopathology.
Employee and Coworker Idiosyncratic Deals: Implications for Emotional Exhaustion and Deviant Behaviors

By integrating conservation of resources and social comparison perspectives, we seek to investigate how employees’ own i-deals, independently from and jointly with their coworker’s i-deals, determine their emotional exhaustion and subsequent deviant behaviors. We conducted a field study (131 coworker dyads) focusing on task i-deals, and used Actor–Partner Interdependence Model and polynomial regression to test the hypotheses. We found that emotional exhaustion not only mediated the negative relationship between employees’ own task i-deals and deviant behaviors, but also mediated the positive relationship between upward social comparison of task i-deals (i.e., a coworker’s vs own task i-deals) and deviant behaviors. These results demonstrated the intra- and interpersonal implications of task i-deals for emotional exhaustion and subsequent deviant behaviors. The current research not only shifts the attention from a predominantly positive view on i-deals to a more balanced and nuanced view on i-deals’ implications, but also sheds light on the interpersonal nature of i-deals and the emotional exhaustion implication of upward social comparison.
Abstract GS2-02: Efficacy and utilization trends of adjuvant chemotherapy for stage I, II, and III breast cancer in the elderly population: A National Cancer Database (NCDB) analysis

Background: The role of adjuvant chemotherapy in early stage breast cancer is well established with survival benefit seen in long term follow up studies, but only a small minority of patients in these studies were >65 years old. Dose and schedule can be tailored according to the special requirements of an elderly patient, as stated by the International Society of Geriatric Oncology (SIOG). However the magnitude of the benefit and trends in utilization of adjuvant chemotherapy has not been well studied in this population. Methods: Female patients above 65 years age with stage I to III breast cancer were identified from the NCDB database from 2004-2015. Factors predicting utility of chemotherapy were assessed with multivariate analysis. Kaplan Meier curves were constructed for calculation of overall survival (OS) with hazard ratio (HR) estimated from cox model. Log rank test and pearson chi square was used for comparison between groups. Groups were compared for OS benefit at 5 and 10 years. Results: Of a total of 2,445,730 patients analyzed, 160,676 met our inclusion criteria. Of them, 21,743 were >80 years old. Factors predicting use of adjuvant chemotherapy were shown in table 1. OS benefit was seen in patients who received adjuvant chemotherapy regardless of their age, ER, PR, HER-2 status or stage. Patients with TNBC had an HR of 0.547. More benefit was seen in the higher stages. HR for stages I, II, and III were 0.801, 0.608, and 0.666 respectively. Conclusions: Adjuvant chemotherapy is considered standard of care for patients with early stage breast cancer. Elderly patients are more likely to get adjuvant chemotherapy based on histology, age Citation Format: Sinha S, Panebianco L, Wu X, Wang D, Huang D, Sivapiragasam A. Efficacy and utilization trends of adjuvant chemotherapy for stage I, II, and III breast cancer in the elderly population: A National Cancer Database (NCDB) analysis [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr GS2-02.
Evaluating human neural envelope coding as the basis of speech intelligibility in noise

Models of speech intelligibility that accurately reflect human listening performance across a broad range of background-noise conditions are clinically important (e.g., for deriving hearing-aid prescriptions, and optimizing cochlear-implant signal processing). A leading hypothesis in the field is that internal representations of envelope information ultimately determine intelligibility. However, this hypothesis has not been tested neurophysiologically. Here, we address this gap by combining human electroencephalography (EEG) with simultaneous perceptual intelligibility measurements. First, we derive a neural envelope-coding metric (ENVneural) from EEG responses to speech in multiple levels of stationary noise, and identify a mapping between the neural metric and corresponding speech intelligibility. Then, using the same mapping, we use only EEG measurements to test whether ENVneural is predictive of speech intelligibility in novel background-noise conditions and in the presence of linear and non-linear distortions. Preliminary results suggest that neural envelope coding can predict speech intelligibility to varying degrees for different realistic listening conditions. These results inform modeling approaches based on neural coding of envelopes, and may lead to the future development of physiological assays for characterizing individual differences in speech-in-noise perceptual abilities.
Abstract 2376: Comprehensive multiplexed protein analysis of biomarkers of hypoxia and the immune microenvironment of diffuse large B-cell lymphoma with clinical outcome analysis

Background: The host immune response has been shown to play an important role in the pathogenesis and clinical outcome of diffuse large B-cell lymphoma (DLBCL). Immune checkpoint molecules, such as PDL1, TIM3, and LAG3, can modulate the immune microenvironment by downregulating T-cell activity. Hypoxia inducible factor (HIF) is a transcription factor that regulates genes involved in responses to hypoxia and can induce PDL1 expression. PDL1, TIM3, and HIF1α expression in DLBCL tumor cells have been associated with inferior survival. We performed a comprehensive multiplexed analysis of hypoxia and immune-related proteins to better understand the DLBCL microenvironment. Design: Immunohistochemical (IHC) analysis was performed on 49 DLBCL cases and correlated with clinicopathologic data. A microarray with an additional 36 DLBCL cases was evaluated by IHC and by using the NanoString nCounter Digital Spatial Profiling (DSP) platform with a 30-protein immuno-oncology panel. This study was approved by the UMass IRB. Results: Subsets of tumors were positive by IHC in tumor cells and/or infiltrating non-tumor cells for PDL1 (12%), PD1 (39%), TIM3 (73%), LAG3 (18%), HIF1α (31%) and HIF2α (47%). A positive correlation was found between IHC expression of tumor-associated PDL1, PD1, and TIM3 (r>0.6, p 0.05). HIF1α, but not HIF2α, expression positively correlated with PDL1 IHC expression (p=0.011). Pairwise comparison between proteins using data from the DSP analysis showed positive correlations between PDL1/LAG3 (r=0.71, p Conclusions: A comprehensive protein-level analysis of the immune microenvironment of DLBCL reveals coordinated expression of several therapeutically-relevant immunomodulatory molecules. HIF1α expression strongly correlated with PDL1 and other immune checkpoint molecules and was associated with inferior patient outcome. Further studies are required to elucidate causative links between hypoxia and the immune environment of lymphoma, as well as potential clinical and therapeutic implications of these findings. Citation Format: Vladislav V. Makarenko, Karen Dresser, Benjamin J. Chen. Comprehensive multiplexed protein analysis of biomarkers of hypoxia and the immune microenvironment of diffuse large B-cell lymphoma with clinical outcome analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2376.
Parameterizing a borosilicate waste glass degradation model

Borosilicate waste glass degradation models must quantify the effects of the solution composition on the dissolution rate. Here, we present results of modified ASTM C1285 tests conducted at 90 °C with AFCI and LRM glasses to determine whether dependencies of dissolution rates on the pH, Al, and Si concentrations must be included. Solution compositions were modified from those generated by glass dissolution alone by adding small amounts of K4SiO4 glass, Al(OH)3•2H2O, and a concentrated NaOH solution when the tests were initiated. Results show rate laws for the initial and resumption regimes must include pH dependences, but the residual rate can be modeled independent of the pH, Al, and Si concentrations. Triggering the resumption rate probably depends on the pH, Si, and Al concentrations and perhaps other aspects of the glass composition. A waste glass degradation model using is being parameterized using tests with a range of waste glass compositions to quantify these dependencies.
HEARING IMPAIRMENT, COGNITIVE PERFORMANCE, AND BETA-AMYLOID DEPOSITION IN THE ARIC-PET AMYLOID IMAGING STUDY

Hearing impairment is a risk factor for dementia but the mechanism underlying this association is unknown. We investigated the relationship between hearing and cognitive performance and brain β-amyloid deposition in 252 adults aged 67-88 years (37% black race) without dementia from three U.S. communities. Global cortical standardized uptake value ratios (SUVRs) were calculated from florbetapir-positron emission tomography scans, with elevated SUVR defined as >1.2 (the median value). Air conduction hearing threshold levels for the frequencies of 0.5, 1, 2 and 4 kHz were obtained by pure tone audiometry and averaged for the better-hearing ear to yield a pure tone average (PTA) in decibels hearing level (dB). A composite cognitive score was created from ten neuropsychological tests summarized using latent variable methods. Multivariable-adjusted linear and Poisson regression with robust standard errors were used to estimate the average difference in cognitive scores and prevalence of elevated SUVR, respectively, by hearing impairment status. In analyses adjusted for age, sex, education and APOE e4 status, hearing was not associated with elevated SUVR [prevalence ratio per 10 db increase (worse hearing) = 0.94 (95% CI: 0.84, 1.04)]. Results did not differ by race. In contrast, each 10 db increase in hearing impairment was associated with 0.08 standard deviation (95% CI: 0.02, 0.15) lower cognitive score, after adjustment for demographic and cardiovascular factors. Poorer hearing is associated with poorer cognitive performance but not with amyloid deposition, suggesting that the mechanism underlying the relationship between hearing and cognition may be independent of Alzheimer’s-related pathologic brain changes.
Wellhead based time domain reflectometry for casing integrity investigation

Abstract Wellbore integrity is one of the most critical factors for CO2 storage, subsurface resource extraction, and waste disposal. Wellbore integrity monitoring is challenging due to the general inaccessibility and high cost of well-logging operation in complex subsurface conditions. In this study, we tested a novel non-invasive approach for wellbore-integrity assessment based on time-domain reflectometry (TDR) method. With this method, a high-frequency electromagnetic pulse is sent into the borehole casing, and the reflected signals due to integrity-related impedance anomalies are recorded at the wellhead, providing rapid borehole integrity diagnosis without downhole deployment. Laboratory, numerical, and field experiments were conducted to prove the feasibility of this approach. The laboratory experiments with coaxial cable, resembling the typical wellbore, showed clear reflected signals from both of the damaged section and the end of the cable. Numerical sensitivity tests indicated that the TDR response is affected by the changes of the material in the borehole, including infilled fluids. Our field trial was conducted on an oil well (with a depth of 240 m) in the central valley region of southern California. The TDR records showed a clear reflection that matched both the calculated two-way travel time from the bottom of the borehole, as well as the numerical simulation. Our results suggested the feasibility of the TDR method for quick assessment of wellbore integrity based on wellhead only deployment.
Digital LDO Based Power Signature Generation Circuit for IoT Security

Power analysis or power fingerprinting has been demonstrated as a potent tool to detect malicious operation or adversary attacks. However, current methods to extract power traces for power analysis typically require bulky and power hungry equipment, which prevents integrating power analysis methods in IoT devices. This work presents a novel method to extract the power signature of IoT devices. The proposed method takes advantage of the digital control signals of digital LDO circuits and generates the power signature with simple circuits. The proposed circuit can be embedded into LDO circuits and hence is suitable for IoT applications. The proposed circuit is designed using a 130 nm CMOS technology and its performance is evaluated via simulation with real sensor power trace data.
Design and Fabrication of a MEMS-Based Break Junction Device for Mechanical Strain-Correlated Optical Characterization of a Single-Molecule

Here, we propose a robust lab-on-a-chip system for multi-dimensional (electrical, optical, and mechanical) characterization of a single-molecule utilizing a Si micromachined micro-electromechanical-system (MEMS) chip. Our MEMS-based break junction (MEMS-BJ) utilizes conventional MEMS chip fabrication techniques to create an electrostatic comb actuator capable of trapping a single-molecule between two nanoscale metal electrodes with sub-nanometer displacement resolution. In order to achieve this functionality, components of the chip (e.g flexural spring, comb drive fingers) are delicately designed based on an analytical model and basic performance parameters are verified using a finite element analysis simulation and capacitive sensor measurements. Using this system, we are able to perform combined single-molecule Raman spectroscopy and molecular conductance measurements in real-time. Finally, we present a representative case study of the multi-dimensional characterization of a single-molecule junction by analyzing correlated electrical, optical, and mechanical information while mechanically modulating the strain on the junction which allows for direct observation of the interplay between molecular structure and electron transport. We believe that our MEMS-BJ system will enable a deeper multi-dimensional study at a single-molecule level promoting the development of new methods for chemical and biological sensor applications. [2020-0307]
Equivalences of LLT polynomials via lattice paths

The LLT polynomials $\mathcal{L}_{\mathbf{\beta}/\mathbf{\gamma}} (X;t)$ are a family of symmetric polynomials indexed by a tuple of (possibly skew-)partitions $\mathbf{\beta}/\mathbf{\gamma}= (\beta^{(1)}/\gamma^{(1)},\ldots,\beta^{(k)}/\gamma^{(k)})$. It has recently been shown that these polynomials can be seen as the partition function of a certain vertex model whose boundary conditions are determined by $\mathbf{\beta}/\mathbf{\gamma}$. In this paper we describe an algorithm which gives a bijection between the configurations of the vertex model with boundary condition $\mathbf{\beta}/\mathbf{\gamma} = (\beta^{(1)}/\gamma^{(1)},\beta^{(2)}/\gamma^{(2)})$ and those with boundary condition $(\mathbf{\beta}/\mathbf{\gamma})_{swap} = (\beta^{(2)}/\gamma^{(2)},\beta^{(1)}/\gamma^{(1)})$. We prove a sufficient condition for when this bijection is weight-preserving up to an overall factor of $t$, which in turn implies that the corresponding LLT polynomials are equal up to the same overall factor. Using these techniques, we are also able to systematically determine linear relations within families of LLT polynomials.
Using Forms Quizzes to Enhance Students’ Motivation in Language Learning at a Japanese University

This study explores the effective utilization of the online program Forms via smartphones to enrich the classroom experience for both students and teachers in two prep classes for the standardized English Test, Eiken. The instructor used Forms to create, distribute, collect, and analyze surveys and quizzes. Students' attitudes toward English and their motivation to learn the language using these tools were examined. Via smartphones, they were given review quizzes that had game-like elements and that gave feedback in real time. Surveys investigating the degree of confidence in learning, the review quizzes, and smartphone usage were also distributed to their smartphones. The results indicate improvement in attitude towards English in general and enhanced confidence.
Biologic Therapy in HIV: To Screen or Not to Screen.

Biologic therapy has revolutionized the management of chronic inflammatory diseases, including inflammatory bowel disease (IBD). Before the initiation of therapy, it is critical to rule out prior infection of chronic hepatitis B virus (HBV) and tuberculosis (TB). However, screening for human immunodeficiency virus (HIV) is not as routinely completed. We present a case of a 56-year-old male on ustekinumab for the management of Crohn's disease, found to have undiagnosed human immunodeficiency virus (HIV) with progression to acquired immunodeficiency syndrome (AIDS).