cssi/SciSciGPT-SciSciNet huggingface dataset:
Cholesterol Sulfonation Enzyme, SULT2B1b, Modulates AR and Cell Growth Properties in Prostate Cancer

Cholesterol accumulates in prostate lesions and has been linked to prostate cancer incidence and progression. However, how accumulated cholesterol contributes to prostate cancer development and progression is not completely understood. Cholesterol sulfate (CS), the primary sulfonation product of cholesterol sulfotransferase (SULT2B1b), accumulates in human prostate adenocarcinoma and precancerous prostatic intraepithelial neoplasia (PIN) lesions compared with normal regions of the same tissue sample. Given the enhanced accumulation of CS in these lesions, it was hypothesized that SULT2B1b-mediated production of CS provides a growth advantage to these cells. To address this, prostate cancer cells with RNAi-mediated knockdown (KD) of SULT2B1b were used to assess the impact on cell growth and survival. SULT2B1b is expressed and functional in a variety of prostate cells, and the data demonstrate that SULT2B1b KD, in LNCaP and other androgen-responsive (VCaP and C4-2) cells, results in decreased cell growth/viability and induces cell death. SULT2B1b KD also decreases androgen receptor (AR) activity and expression at mRNA and protein levels. While AR overexpression has no impact on SULT2B1b KD-mediated cell death, the addition of exogenous androgen is able to partially rescue the growth inhibition induced by SULT2B1b KD in LNCaP cells. These results suggest that SULT2B1b positively regulates the AR either through alterations in ligand availability or by interaction with critical coregulators that influence AR activity. Implications: These findings provide evidence that SULT2B1b is a novel regulator of AR activity and cell growth in prostate cancer and should be further investigated for therapeutic potential. Mol Cancer Res; 14(9); 776–86. ©2016 AACR.
Risk of cancer in small and diminutive colorectal polyps

The prevalence of cancer in small and diminutive polyps is relevant to "resect and discard" and CT colonography reporting recommendations. We evaluated a prospectively collected colonoscopy polyp database to identify polyps <10mm and those with cancer or advanced histology (high-grade dysplasia or villous elements). Of 32,790 colonoscopies, 15,558 colonoscopies detected 42,630 polyps <10mm in size. A total of 4790 lesions were excluded as they were not conventional adenomas or serrated class lesions. There were 23,524 conventional adenomas <10mm of which 22,952 were tubular adenomas. There were 14,316 serrated class lesions of which 13,589 were hyperplastic polyps and the remainder were sessile serrated polyps. Of all conventional adenomas, 96 had high-grade dysplasia including 0.3% of adenomas ≤5mm in size and 0.8% of adenomas 6-9mm in size. Of all conventional adenomas, 2.1% of those ≤5mm in size and 5.6% of those 6-9mm in size were advanced. Among 36,107 polyps ≤5mm in size and 6523 polyps 6-9mm in size, there were no cancers. These results support the safety of resect and discard as well as current CT colonography reporting recommendations for small and diminutive polyps.
Combined Theoretical and Experimental Approach to the Discovery of Electrochemically Active Mixed Polyanionic Phosphatonitrates, AFePO4NO3 (A = NH4/Li, K)

A new class of mixed polyanionic transition metal phosphatonitrate with the general formula AFePO4NO3 (A = NH4/Li, K) has been synthesized following a computational predictive study based on DFT calculations. Structures of the crystalline products have been solved through synchrotron powder XRD and single-crystal XRD techniques. This class of materials exhibits the rare coordination of PO43– and NO3– to a single transition metal center and is structurally related to the rare mineral bonshtedtite (Na3FePO4CO3), which has been used as the initial model for predicting phosphatonitrates. (NH4)1–xLixFePO4NO3 has been found to be capable of reversible electrochemical Li- and Na-ion intercalation in the potential range 2.0–4.2 V at a theoretical capacity of ca. 116 mAh·g–1. Various aspects of structural, chemical/electrochemical, and spectroscopic features of AFePO4NO3 have been discussed in this article.
The Development of Keynesian Macroeconomics

In this paper I will outline the historical development of Keynesian macroeconomics and add a few remarks. My version of the story will agree with textbook accounts in some ways, and differ fairly sharply in others. Very few references will be provided in support of assertions both because space is limited and because my version is something of a “stylized history of thought.” The hope is that it will be, like carefully selected “stylized facts,” analytically illuminating although lacking in detail.
Are agricultural R&D returns declining and development dependent?

Abstract There is widespread professional consensus that agricultural research and development (R&D) realizes high economic returns, though there are concerns as to whether the returns have been declining over the past few decades and are unevenly distributed among different regions in the world. This study examines both the time trend (i.e., increasing or decreasing) and regional developmental differences in the reported returns to agricultural R&D. Using a newly updated and expanded global database of estimated returns to agricultural R&D and a robust statistical methodology, we find that after accounting for methodological changes and other study attributes that have varied over time, the contemporary returns to agricultural R&D investments are as high as ever. We also conduct a Oaxaca decomposition to assess the relative importance of differences among countries in study attributes (e.g., what research was evaluated, by whom, and how) versus differences in how these attributes relate to the IRR (e.g., model parameter estimates). We find that the regional differences in study attributes tend to result in higher IRR estimates in developed countries, whereas developing versus developed country differences in the marginal effects of the attributes on the estimated IRRs tend to result in higher estimates in developing countries.
Charge carrier transport and lifetimes in n-type and p-type phosphorene as 2D device active materials: an ab initio study.

In this work, we provide a detailed analysis of phosphorene’s performance as an n-type and p-type active material. This study is based on first principles calculations of the phosphorene electronic structure, and the resulting electron and hole scattering rates and lifetimes. Emphasis is put on extreme regimes commonly found in semiconductor devices, i.e. high electric fields and heavy doping, where impact ionization and Auger recombination can occur. We found that electron-initiated impact ionization is weaker than the hole-initiated process, when compared to carrier–phonon interaction rates, suggesting resilience to impact ionization initiated breakdown. Moreover, calculated minority electron lifetimes are limited by radiative recombination only, not by Auger processes, suggesting that phosphorene could achieve good quantum efficiencies in optoelectronic devices. The provided scattering rates and lifetimes are critical input data for the modeling and understanding of phosphorene-based device physics.
Executing Dynamic Data-Graph Computations Deterministically Using Chromatic Scheduling

A data-graph computation—popularized by such programming systems as Galois, Pregel, GraphLab, PowerGraph, and GraphChi—is an algorithm that performs local updates on the vertices of a graph. During each round of a data-graph computation, an update function atomically modifies the data associated with a vertex as a function of the vertex’s prior data and that of adjacent vertices. A dynamic data-graph computation updates only an active subset of the vertices during a round, and those updates determine the set of active vertices for the next round.This article introduces Prism, a chromatic-scheduling algorithm for executing dynamic data-graph computations. Prism uses a vertex coloring of the graph to coordinate updates performed in a round, precluding the need for mutual-exclusion locks or other nondeterministic data synchronization. A multibag data structure is used by Prism to maintain a dynamic set of active vertices as an unordered set partitioned by color. We analyze Prism using work-span analysis. Let G = (V, E) be a degree-Δ graph colored with χ colors, and suppose that Q⊆V is the set of active vertices in a round. Define size(Q)= vQv + ∑v∈ Q deg(v), which is proportional to the space required to store the vertices of Q using a sparse-graph layout. We show that a P-processor execution of Prism performs updates in Q using O(χ (lg ( Q/χ ) + lg Δ ) + lg P span and Θ(size(Q) + P) work.These theoretical guarantees are matched by good empirical performance. To isolate the effect of the scheduling algorithm on performance, we modified GraphLab to incorporate Prism and studied seven application benchmarks on a 12-core multicore machine. Prism executes the benchmarks 1.2 to 2.1 times faster than GraphLab’s nondeterministic lock-based scheduler while providing deterministic behavior.This article also presents Prism-R, a variation of Prism that executes dynamic data-graph computations deterministically even when updates modify global variables with associative operations. Prism-R satisfies the same theoretical bounds as Prism, but its implementation is more involved, incorporating a multivector data structure to maintain a deterministically ordered set of vertices partitioned by color. Despite its additional complexity, Prism-R is only marginally slower than Prism. On the seven application benchmarks studied, Prism-R incurs a 7p geometric mean overhead relative to Prism.
Discourses of Citizenship in American and Brazilian Affirmative Action Court Decisions

American and Brazilian courts are traveling quite different paths regarding the question of racial justice. Race neutrality has become an influential interpretive approach in both jurisdictions, a perspective that articulates a depiction of these nations as culturally homogenous societies with the defense of liberal principles as a necessary requirement for social cohesion. Because of the representation of Brazil and the United States as democracies that facilitate integration of all racial groups, courts in these countries have developed an equal protection approach that combines the rhetoric of assimilation and formal equality. However, while the discourse of race neutrality gains continuous political force in the United States, race consciousness is acquiring increasing persuasive power in Brazil. As the implementation of affirmative action programs has expanded into different sectors, various social actors have questioned their constitutionality. Although state and federal courts in Brazil have condemned affirmative action because it supposedly subverts liberal principles and moral consensus about equal racial treatment, the Brazilian Supreme Court has recently classified race neutrality as a strategy of racial domination. Differently from American affirmative action cases, this decision formulated a notion of citizenship that functions as a counterhegemonic narrative. In articulating progressive constitutional principles and a group-oriented equal protection perspective, the Brazilian Supreme Court has significantly contributed to the deconstruction of the traditional discourse of race transcendence. The Court’s decisions may serve as an interesting point of comparison for the debate about affirmative action in the United States, since Brazilian history shows very clearly how race neutrality allows majoritarian groups to defend racial privilege while advocating formal equality as a way to promote social inclusion.
Pilot Study: Implementing a Brief DBT Skills Program in Schools to Reduce Health Risk Behaviors Among Early Adolescents

A significant proportion of youth engage in health risk behaviors, which are of concern, as they are associated with adverse health consequences across development. Two factors associated with enga...
Characterization Of [11C]-GSK1482160 For Targeting The P2X7 Receptor As A Biomarker For Neuroinflammation

The purinergic receptor subtype 7 (P2X7R) represents a novel molecular target for imaging neuroinflammation via PET. GSK1482160, a potent P2X7R antagonist, has high receptor affinity, high blood-brain barrier penetration, and the ability to be radiolabeled with 11C. We report the initial physical and biologic characterization of this novel ligand. Methods:11C-GSK1482160 was synthesized according to published methods. Cell density studies were performed on human embryonic kidney cell lines expressing human P2X7R (HEK293-hP2X7R) and underwent Western blotting, an immunofluorescence assay, and radioimmunohistochemistry analysis using P2X7R polyclonal antibodies. Receptor density and binding potential were determined by saturation and association-disassociation kinetics, respectively. Peak immune response to lipopolysaccharide treatment in mice was determined in time course studies and analyzed via Iba1 and P2X7R Western blotting and Iba1 immunohistochemistry. Whole-animal biodistribution studies were performed on saline- or lipopolysaccharide-treated mice at 15, 30, and 60 min after radiotracer administration. Dynamic in vivo PET/CT was performed on the mice at 72 h after administration of saline, lipopolysaccharide, or lipopolysaccharide + blocking, and 2-compartment, 5-parameter tracer kinetic modeling of brain regions was performed. Results: P2X7R changed linearly with concentrations or cell numbers. For high-specific-activity 11C-GSK1482160, receptor density and Kd were 1.15 ± 0.12 nM and 3.03 ± 0.10 pmol/mg, respectively, in HEK293-hP2X7R membranes. Association constant kon, dissociation constant koff, and binding potential (kon/koff) in HEK293-hP2X7R cells were 0.2312 ± 0.01542 min-1⋅nM-1, 0.2547 ± 0.0155 min-1, and 1.0277 ± 0.207, respectively. Whole-brain Iba1 expression in lipopolysaccharide-treated mice peaked by 72 h on immunohistochemistry, and Western blot analysis of P2X7R for saline- and lipopolysaccharide-treated brain sections showed a respective 1.8- and 1.7-fold increase in signal enhancement at 72 h. Biodistribution of 11C-GSK1482160 in saline- and lipopolysaccharide-treated mice at 72 h was statistically significant across all tissues studied. In vivo dynamic 11C-GSK1482160 PET/CT of mice at 72 h after administration of saline, lipopolysaccharide, or lipopolysaccharide + blocking showed a 3.2-fold increase and 97% blocking by 30 min. The total distribution volumes for multiple cortical regions and the hippocampus showed statistically significant increases and were blocked by an excess of authentic standard GSK1482160. Conclusion: The current study provides compelling data that support the suitability of 11C-GSK1482160 as a radioligand targeting P2X7R, a biomarker of neuroinflammation.
General degeneracy in density functional perturbation theory

Degenerate perturbation theory from quantum mechanics is inadequate in density functional theory (DFT) because of nonlinearity in the Kohn-Sham potential. Herein, we develop the fully general perturbation theory for open-shell, degenerate systems in Kohn-Sham DFT, without assuming the presence of symmetry or equal occupation of degenerate orbitals. To demonstrate the resulting methodology, we apply it to the iron atom in the central field approximation, perturbed by an electric quadrupole. This system was chosen because it displays both symmetry required degeneracy, between the five $3d$ orbitals, as well as accidental degeneracy, between the $3d$ and $4s$ orbitals. The quadrupole potential couples the degenerate $3d$ and $4s$ states, serving as an example of the most general perturbation.
Fundamental trade-offs in aggregate packet scheduling

We investigate the fundamental trade-offs in aggregate packet scheduling for the support of guaranteed delay service. Besides the simple FIFO packet scheduling algorithm, we consider two new classes of aggregate packet scheduling algorithms: the static earliest time first (SETF) and dynamic earliest time first (DETF). Through these two classes of aggregate packet scheduling, we show that, with additional time stamp information encoded in the packet header for scheduling purpose, we can significantly increase the maximum allowable network utilization level, while at the same time reducing the worst-case edge-to-edge delay bound. Furthermore, we demonstrate how the number of the bits used to encode the time stamp information affects the trade-off between the maximum allowable network utilization level and the worst-case edge-to-edge delay bound. In addition, the more complex DETF algorithms have far better performance than the simpler SETF algorithms. These results illustrate the fundamental trade-offs in aggregate packet scheduling algorithms and shed light on their provisioning power in support of guaranteed delay service.
Criminal background and job performance

Job applicants with criminal records are much less likely than others to obtain legitimate employment. Recent efforts to address this problem include campaigns to persuade employers to hire applicants with a record voluntarily and legislation such as Ban the Box laws. The success of any remedial strategy depends on whether employer concerns are founded on an accurate view of how employees with a criminal background behave on the job if hired. Little empirical evidence now exists to answer this question. This paper attempts to fill this gap by examining firm-level hiring practices and worker-level performance outcomes. Our data indicate that individuals with criminal records have a much longer tenure and are less likely to quit their jobs voluntarily than other workers. Some results, however, differ by job: sales employees with a criminal record have a higher tendency than other workers to leave because of misconduct, while this effect is smaller and less significant for customer service workers. By examining psychometric data, we find evidence that bad outcomes for sales people with records may be driven by job rather than employee characteristics. We find some evidence that psychometric testing might provide a substitute for the use of criminal records, but that it would not in our own sample.
A 17.1 GHz free-electron laser as a microwave source for TeV colliders

Abstract We describe the proposed developement of a 17.1 GHz microwave source based on an induction-linac-driven free-electron laser that is expected to produce peak power levels at the several-GW level. This system is being designed to serve as the power source for a TeV linear collider or for other high-gradient accelerators. We will discuss the power-source requirements for TeV colliders and present the initial design of an FEL that will produce the desired power. In addition, we shall discuss efficiency enhancement schemes such as a relativistic klystron “afterburner”, the requirements for beam reacceleration, and concepts for extraction of the microwave power while preserving key properties of the beam such as emittance and phase.
The reactions of active nitrogen with polyolefins

Active nitrogen is the product of an electric discharge in nitrogen1. It is characterized by a prolonged yellow afterglow and strong chemical reactivity. The latter is mostly due to nitrogen atoms in the ground state. Their homogeneous reactions with gaseous molecules, including hydro-carbons, have been studied extensively2, but this is the first study of reactions of active nitrogen with polymers.
iDroop: A Dynamic Droop controller to decouple power grid's steady-state and dynamic performance

This paper presents a novel Dynam-i-c Droop (iDroop) control mechanism to perform primary frequency control with gird-connected inverters that improves the network dynamic performance. The work is motivated by the dynamic degradation experienced by the power grid due to the increase in asynchronous inverted-based generation. We show that the widely suggested virtual inertia solution suffers from unbounded noise amplification (infinite ℋ 2 norm) when measurement noise is considered. This suggests that virtual inertia could potentially further degrade the grid performance once broadly deployed. This motivates the proposed solution in this paper that overcomes the limitations of virtual inertia controllers while sharing the same advantages of traditional droop control. In particular, our iDroop controllers are decentralized, rebalance supply and demand, and provide power sharing. Furthermore, our solution can improve the dynamic performance without affecting the steady state solution. Our algorithm can be incrementally deployed and can be guaranteed to be stable using a decentralized sufficient stability condition on the parameter values. We illustrate several features of our solution using numerical simulations.
Algorithmic Information Theory

This paper reviews algorithmic information theory, which is an attempt to apply information-theoretic and probabilistic ideas to recursive function theory. Typical concerns in this approach are, for example, the number of bits of information required to specify an algorithm, or the probability that a program whose bits are chosen by coin flipping produces a given output. During the past few years the definitions of algorithmic information theory have been reformulated. The basic features of the new formalism are presented here and certain results of R. M. Solovay are reported.
Absorptive capacity and R&D outsourcing

Abstract I analyze the determinants of research and development (R&D) outsourcing, or investments in R&D purchased from external providers. I build on the knowledge-based view of the firm (KBV) and the concept of absorptive capacity to propose a separation between the mechanisms that form the potential absorptive capacity that enables the firm to identify and integrate outsourced R&D knowledge into the firm, from the mechanisms that form the realized absorptive capacity that enables the firm to use and transform outsourced R&D knowledge into innovation. First, I propose that firms that engage with foreign customers and with foreign suppliers develop the potential absorptive capacity, an ability to understand new and complex external knowledge that is useful for integrating it with firm-internal knowledge, and thus invest more in R&D outsourcing. Second, I argue that firms that have more skilled employees and invest more in internal R&D develop the realized absorptive capacity, an ability to use and transform external knowledge, and as a result invest more in R&D outsourcing. Finally, I propose that these relationships are weakened when the firms are subsidiaries of foreign multinational firms operating in the country, because these firms can also build their absorptive capacity by being integrated with other country subsidiaries and the headquarters within the multinational. I test these arguments on a sample of manufacturing firms and find that firms that import, export, have more skilled employees, and have more internal R&D investment tend to invest more in R&D outsourcing. I also find that, for subsidiaries of foreign firms, the impact of skilled employees and internal R&D on R&D outsourcing is lower than for domestic firms. These ideas provide a theory-driven explanation of the determinants of R&D outsourcing that refine the notion of absorptive capacity and its two dimensions, potential and realized.
Savoring an Upcoming Experience Affects Ongoing and Remembered Consumption Enjoyment

AbstractFive studies, using diverse methodologies, distinct consumption experiences, and different manipulations, demonstrate the novel finding that savoring an upcoming consumption experience heightens enjoyment of the experience both as it unfolds in real time (ongoing enjoyment) and when it is remembered (remembered enjoyment). This theory predicts that the process of savoring an upcoming experience creates affective memory traces that are reactivated and integrated into the actual and remembered consumption experience. Consistent with this theorizing, factors that interfere with consumers’ motivation, ability, or opportunity to form or retrieve affective memory traces of savoring an upcoming experience limit the effect of savoring on ongoing and remembered consumption enjoyment. Affective expectations, moods, imagery, and mindsets do not explain the observed findings.
Deep integration and UK-EU trade relations

This paper studies the impact of deep agreements on UK–EU trade relations. Specifically, we apply a standard gravity model to assess the effect that EU membership had on UK trade and then use the estimates from this analysis to evaluate the future of UK–EU trade relations under different scenarios. Differently from previous studies, we use new information on the content of trade agreements to build a measure of “depth” based on the number of provisions they cover and we rely on information on goods, services and value-added trade from the World Input Output Database (WIOD). The key finding is that as the UK benefited from large trade gains from EU membership, its undoing may lead to substantial trade losses.
Dynamical and Radiative Properties of X-Ray Pulsar Accretion Columns: Phase-averaged Spectra

The availability of the unprecedented spectral resolution provided by modern X-ray observatories is opening up new areas for study involving the coupled formation of the continuum emission and the cyclotron absorption features in accretion-powered X-ray pulsar spectra. Previous research focusing on the dynamics and the associated formation of the observed spectra has largely been confined to the single-fluid model, in which the super-Eddington luminosity inside the column decelerates the flow to rest at the stellar surface, while the dynamical effect of gas pressure is ignored. In a companion paper, we have presented a detailed analysis of the hydrodynamic and thermodynamic structure of the accretion column obtained using a new self-consistent model that includes the effects of both gas and radiation pressure. In this paper, we explore the formation of the associated X-ray spectra using a rigorous photon transport equation that is consistent with the hydrodynamic and thermodynamic structure of the column. We use the new model to obtain phase-averaged spectra and partially-occulted spectra for Her X-1, Cen X-3, and LMC X-4. We also use the new model to constrain the emission geometry, and compare the resulting parameters with those obtained using previously published models. Our model sheds new light on the structure of the column, the relationship between the ionized gas and the photons, the competition between diffusive and advective transport, and the magnitude of the energy-averaged cyclotron scattering cross section.
Estimation of vertex degrees in a sampled network

The need to produce accurate estimates of vertex degree in a large network, based on observation of a subnetwork, arises in a number of practical settings. We study a formalized version of this problem, wherein the goal is, given a randomly sampled subnetwork from a large parent network, to estimate the actual degree of the sampled nodes. Depending on the sampling scheme, trivial method of moments estimators (MMEs) can be used. However, the MME is not expected, in general, to use all relevant network information. In this study, we propose a handful of novel estimators derived from a risk-theoretic perspective, which make more sophisticated use of the information in the sampled network. Theoretical assessment of the new estimators characterizes under what conditions they can offer improvement over the MME, while numerical comparisons show that when such improvement obtains, it can be substantial. Illustration is provided on a peer-to-peer communication network.
Preferential Structures for Comparative Probabilistic Reasoning

Author(s): Harrison-Trainor, Matthew; Holliday, Wesley Halcrow; Icard, Thomas Frederick, III | Abstract: Qualitative and quantitative approaches to reasoning about uncertainty can lead to different logical systems for formalizing such reasoning, even when the language for expressing uncertainty is the same. In the case of reasoning about relative likelihood, with statements of the form φ ≥nψnexpressing that φnis at least as likely as ψ, a standard qualitative approach using preordered preferential structures yields a dramatically different logical system than a quantitative ap- proach using probability measures. In fact, the standard pref- erential approach validates principles of reasoning that are incorrect from a probabilistic point of view. However, in this paper we show that a natural modification of the preferential approach yields exactly the same logical system as a probabilistic approach—not using single probability measures, but rather sets of probability measures. Thus, the same preferential structures used in the study of non-monotonic logics and belief revision may be used in the study of comparative probabilistic reasoning based on imprecise probabilities.
Recent developments in the use of polymers as reactants in organic reactions

Abstract In a review article [ Accounts Chem. Res. , 2 , 217 (1969)] is a summation of our work up to 1968. In this review we summarized the activity of polyvinylimidazole and copolymers in esterolytic reactions. We explained the increased reactivity of these polymeric reactants in terms of cooperative effects and electrostatic factors. In 1967, we blundered into the extremely interesting discovery that long-chain esters provided us with enormous acceleration of rates at room temperature and we have attributed this in “general” terminology to apolar bonding as a third factor to understand the high reactivity of these synthetic macromolecules. Reference 1 describes our recent published work. We are heavily emphasizing the apolar bonding concept. Related work which conceptually can be regarded as similar to our own discovery was carried out by the group of Professor Irving M. Klotz at Northwestern (2), the group of Professor Kabanov at the University of Moscow (3), and the group of Professor Kunitake (4).
Optimal Tuning for Divide-and-conquer Kernel Ridge Regression with Massive Data

We propose a first data-driven tuning procedure for divide-and-conquer kernel ridge regression (Zhang et al., 2015). While the proposed criterion is computationally scalable for massive data sets, it is also shown to be asymptotically optimal under mild conditions. The effectiveness of our method is illustrated by extensive simulations and an application to Million Song Dataset.
Accounting for Finite Flash Duration in Diffusivity Experiments

The laser flash method, as a means of measuring thermal diffusivity, is well established, and several manufacturers produce equipment for performing these types of experiments. Over time, mathematical models of increasing sophistication employing nonlinear regression have been used in the analysis of flash diffusivity experiments. These models have historically assumed an instantaneous flash and have been highly accurate for most samples of moderate diffusivity and sample thickness. As samples become thinner and more highly conductive, the duration of the experiments becomes very short. Since the duration of the flash is typically on the order of several milliseconds, the assumption that this period of time is instantaneous becomes less valid for very short experiments. In the present research, three models accounting for the duration of the flash are applied to three samples of stainless steel of varying thicknesses and compared with a model that assumes an instantaneous flash. The models accounting for the finite flash duration generate results that are much more consistent between samples than the model assuming an instantaneous flash. Moreover, the conformance of the mathematical models accounting for flash duration is much closer to the measured data than the model that assumes an instantaneous flash.
The Mitochondrial DNA Polymerase Promotes Elimination of Paternal Mitochondrial Genomes

Mitochondrial DNA (mtDNA) is typically inherited from only one parent [1-3]. In animals, this is usually the mother. Maternal inheritance is often presented as the passive outcome of the difference in cytoplasmic content of egg and sperm; however, active programs enforce uniparental inheritance at two levels, eliminating paternal mitochondrial genomes or destroying mitochondria delivered to the zygote by the sperm [4-13]. Both levels operate in Drosophila [8, 12, 13]. As sperm formation begins, hundreds of doomed mitochondrial genomes are visualized within the two huge mitochondria of each spermatid. These genomes abruptly disappear during spermatogenesis. Genome elimination, which is not in the interests of the restricted genomes, is directed by nuclear genes. Mutation of EndoG, which encodes a mitochondria-targeted endonuclease, retarded elimination [8]. Here, we show that knockdown of the nuclear-encoded mtDNA polymerase (Pol γ-α), Tamas, produces a more complete block of mtDNA elimination. Tamas is found in large particles that localize to mtDNA during genome elimination. We discount a simple possible mechanism by showing that the 3'-exonuclease function of the polymerase is not needed. While DNA elimination is a surprising function for DNA polymerase, it could provide a robust nexus for nuclear control of mitochondrial genome copy number, since use of common interactions for elimination and replication might limit options for the mitochondrial genome to escape restriction. We suggest that the DNA polymerase may play this role more widely and that inappropriate activation of its elimination ability might underlie association of DNA loss syndromes with mutations of the human mtDNA polymerase [14-16].
Machine Discovery of Effective Admissible Heuristics

Admissible heuristics are an important class of heuristics worth discovering: they guarantee shortest path solutions in search algorithms such as A* and they guarantee less expensively produced, but boundedly longer solutions in search algorithms such as dynamic weighting. Unfortunately, effective (accurate and cheap to compute) admissible heuristics can take years for people to discover. Several researchers have suggested that certain transformations of a problem can be used to generate admissible heuristics. This article defines a more general class of transformations, called abstractions, that are guaranteed to generate only admissible heuristics. It also describes and evaluates an implemented program (Absolver II) that uses a means-ends analysis search control strategy to discover abstracted problems that result in effective admissible heuristics. Absolver II discovered several well-known and a few novel admissible heuristics, including the first known effective one for Rubik's Cube, thus concretely demonstrating that effective admissible heuristics can be tractably discovered by a machine.
Artificially atomic-scale ordered superlattice alloys for thermoelectric applications

We report artificially atomic-scale ordered superlattice alloy systems, new scheme to pursue high-ZT materials. We have fabricated Bi/Sb superlattice alloys that are artificially ordered on the atomic scale using MBE, confirmed by the presence of XRD superlattice satellites. We have observed that the electronic structure can be modified from semimetal, through zero-gap, to semiconductor by changing the superlattice period and sublayer thicknesses using electrical resistivity, thermopower, and magneto-transport measurements. InSb/Bi superlattice alloys have also been prepared and studied using XRD and thermopower measurements, which shows that their thermoelectric transport properties can be modified in accordance with structural modification. This superlattice alloy scheme gives us one more tool to control and tune the electronic structure and consequently the thermoelectric properties.
Cascaded Segmentation-Detection Networks for Word-Level Text Spotting

We introduce an algorithm for word-level text spotting that is able to accurately and reliably determine the bounding regions of individual words of text "in the wild". Our system is formed by the cascade of two convolutional neural networks. The first network is fully convolutional and is in charge of detecting areas containing text. This results in a very reliable but possibly inaccurate segmentation of the input image. The second network (inspired by the popular YOLO architecture) analyzes each segment produced in the first stage, and predicts oriented rectangular regions containing individual words. No post-processing (e.g. text line grouping) is necessary. With execution time of 450 ms for a 1000 by 560 image on a Titan X GPU, our system achieves good performance on the ICDAR 2013, 2015 benchmarks [2], [1].
Leveraging Interleaved Signal Edges for Concurrent Backscatter

One of the central challenges in backscatter is how to enable concurrent transmissions. Most backscatter protocols operate in a sequential TDMA-like manner due to the fact that most nodes cannot overhear each other's transmissions, which is detrimental for throughout and energy consumption. Recent efforts to separate concurrent signals by inverting a system of linear equations is also problematic due to varying channel coefficients caused by system and environmental dynamics. In this paper, we introduce BST, a novel physical layer for backscatter communication that enables concurrent transmission by leveraging vintra-bit multiplexing of OOK signals from multiple tags. The key idea underlying BST is that the reader can sample at considerably higher rates than the tags, hence it can extract time-domain signal edges that result from interleaved transmissions of several tags. Our preliminary experiment results show that BST can achieve 5x the throughput of Buzz and 10x the throughput of TDMA-based solutions, such as EPC Gen 2.
Learning Analytics and the Academic Library: Professional Ethics Commitments at a Crossroads

In this paper, the authors address learning analytics and the ways academic libraries are beginning to participate in wider institutional learning analytics initiatives. Since there are moral issues associated with learning analytics, the authors consider how data mining practices run counter to ethical principles in the American Library Association’s “Code of Ethics.” Specifically, the authors address how learning analytics implicates professional commitments to promote intellectual freedom; protect patron privacy and confidentiality; and balance intellectual property interests between library users, their institution, and content creators and vendors. The authors recommend that librarians should embed their ethical positions in technological designs, practices, and governance mechanisms.
Online Linear Optimization via Smoothing

We present a new optimization-theoretic approach to analyzing Follow-the-Leader style algorithms, particularly in the setting where perturbations are used as a tool for regularization. We show that adding a strongly convex penalty function to the decision rule and adding stochastic perturbations to data correspond to deterministic and stochastic smoothing operations, respectively. We establish an equivalence between "Follow the Regularized Leader" and "Follow the Perturbed Leader" up to the smoothness properties. This intuition leads to a new generic analysis framework that recovers and improves the previous known regret bounds of the class of algorithms commonly known as Follow the Perturbed Leader.
Perspectives on Corporate Tax Planning: Observations from the Past Decade

ABSTRACT Interest in corporate tax planning has accelerated in recent years as a combination of political, economic, and technological factors have fueled the public's awareness of corporate tax ac...
Is U.S. corporate income double-taxed?

Using data from several sources, we show that the vast majority of corporate income is not double-taxed in the United States. We estimate that the taxable share of U.S. corporate equity has decline...
Guidelines for the management of the older cancer patient

The review allows the following conclusions: 1. Some form of geriatric assessment appear beneficial for older cancer patients; this assessment may allow to estimate life-expectancy and tolerance of treatment, to reveal reversible conditions that may influence the treatment, and to provide a common language to classify older individuals in clinical practice and clinical trials. The geriatric assessment is also the background of any decision analysis related to the study and the management of older patients, capable to accommodate new insights in the biology of cancer and aging and to address problems related to the management of specific diseases. 2. Some age related changes may affect the pharmacology of antineoplastic agents in the majority of older individuals and justify some general guidelines for the administration of chemotherapy that include: Adjustment of the doses of the first chemotherapy to the glomerular filtration rate in individuals aged 65 and older. If no toxicity is observed, the following doses should be increased to prevent under-treatment Prophylactic use of filgrastim or pegfilgrastim in patients aged 65 and older receiving chemotherapy of moderate dose intensity, comparable to CHOP Maintenance of the hemoglobin of patients receiving chemotherapy at 12 gm/dl or higher Aggressive management of mucositis with timely fluid resuscitation Prevention of mucositis by substituting capecitabine for intravenous fluorinated pyrimidine
Transient Community Detection and Its Application to Data Forwarding in Delay Tolerant Networks

Community detection has received considerable attention because of its applications to many practical problems in mobile networks. However, when considering temporal information associated with a community (i.e., transient community), most existing community detection methods fail due to their aggregation of contact information into a single weighted or unweighted network. In this paper, we propose a contact-burst-based clustering method to detect transient communities by exploiting pairwise contact processes. In this method, we formulate each pairwise contact process as a regular appearance of contact bursts, during which most contacts between the pair of nodes happen. Based on this formulation, we detect transient communities by clustering the pairs of nodes with similar contact bursts. Since it is difficult to collect global contact information at individual nodes, we further propose a distributed method to detect transient communities. In addition to transient community detection, we also propose a new data forwarding strategy for delay tolerant networks, in which transient communities serve as the data forwarding unit. Evaluation results show that our strategy can achieve a much higher data delivery ratio than traditional community-based strategies with comparable network overhead.
Markers of Maternal and Infant Metabolism are Associated with Ventricular Dysfunction in Infants of Obese Women with Type 2 Diabetes

BackgroundTo test the hypothesis that infants born to obese women with pre-gestational type 2 diabetes mellitus (IBDMs) have ventricular dysfunction at 1 month that is associated with markers of maternal lipid and glucose metabolism.MethodsIn a prospective observational study of IBDMs (OB+DM, n=25), echocardiographic measures of septal, left (LV) and right ventricular (RV) function, and structure were compared at 1 month of age with those in infants born to OB mothers without DM (OB, n=24) and to infants born to non-OB mothers without DM (Lean, n=23). Basal maternal lipid and glucose kinetics and maternal plasma and infant (cord) plasma were collected for hormone and cytokine analyses.ResultsRV, LV, and septal strain measures were lower in the OB+DM infants compared with those in other groups, without evidence of septal hypertrophy. Maternal hepatic insulin sensitivity, maternal plasma free-fatty-acid concentration, and cord plasma insulin and leptin most strongly predicted decreased septal strain in OB+DM infants.ConclusionIBDMs have reduced septal function at 1 month in the absence of septal hypertrophy, which is associated with altered maternal and infant lipid and glucose metabolism. These findings suggest that maternal obesity and DM may have a prolonged impact on the cardiovascular health of their offspring, despite the resolution of cardiac hypertrophy.
Scheduling Storms and Streams in the Cloud

Motivated by emerging big streaming data processing paradigms (e.g., Twitter Storm, Streaming MapReduce), we investigate the problem of scheduling graphs over a large cluster of servers. Each graph is a job, where nodes represent compute tasks and edges indicate data flows between these compute tasks. Jobs (graphs) arrive randomly over time and, upon completion, leave the system. When a job arrives, the scheduler needs to partition the graph and distribute it over the servers to satisfy load balancing and cost considerations. Specifically, neighboring compute tasks in the graph that are mapped to different servers incur load on the network; thus a mapping of the jobs among the servers incurs a cost that is proportional to the number of “broken edges.” We propose a low-complexity randomized scheduling algorithm that, without service preemptions, stabilizes the system with graph arrivals/departures; more importantly, it allows a smooth tradeoff between minimizing average partitioning cost and average queue lengths. Interestingly, to avoid service preemptions, our approach does not rely on a Gibbs sampler; instead, we show that the corresponding limiting invariant measure has an interpretation stemming from a loss system.
Stage D1 Prostatic Adenocarcinoma: Significance of Nuclear DNA Ploidy Patterns Studied by Flow Cytometry

Flow cytometric analysis of nuclear DNA ploidy pattern was performed on 91 samples of prostatic adenocarcinoma from patients with stage D1 disease (metastatic deposits in pelvic lymph nodes). All patients had undergone radical retropubic prostatectomy and bilateral pelvic lymphadenectomy. Clinical follow-up ranged from 5 to 19 years. Nuclei were extracted from paraffin-embedded archival material. Isolated nuclei were stained with propidium iodide. The DNA ploidy pattern was diploid (normal) in 42% of tumors, tetraploid in 45%, and distinctly aneuploid in 13%. Only 15% of DNA diploid tumors progressed locally or systemically, whereas 75% of tumors with an abnormal DNA ploidy pattern (tetraploid or aneuploid) subsequently progressed ( P P
Low-Dose Testosterone Effect on Somatic Growth

Low-dose testosterone has been found to preserve the growth potential of hypogonadal children requiring anabolic or androgenic therapy. Five girls with Turner syndrome were treated when their chronologic ages were 13 to 14 years and their bone ages were 10.6 to 12.75 years; six hypogonadal boys were treated when their chronologic ages were 11 to 15 years and their bone ages were 10.9 to 14.2 years. Depot testosterone was given as an anabolic agent in an average dose of 28 mg/m2/mo for 6 months to the patients with Turner syndrome and was given to initiate puberty in an average dose of 44 mg/m2/mo for 6 months to the hypogonadal boys. Growth rate doubled on these doses of testosterone, and bone age did not advance disproportionately. Consequently, height potential was preserved. Pubic hair advanced one Tanner stage during the 6-month treatment. Clitoral hypertrophy was observed in only one of the five girls with Turner syndrome and regressed when testosterone therapy was discontinued. Four hypogonadal boys were continued on low-dose testosterone until their bone ages passed 14 years of age and their growth rate waned. Then, the testosterone dosage was increased in increments to 100 to 200 mg/m2/mo. This group reached a height of 100.3 +/- 0.8% of the height initially predicted. In addition, all attained an adult height at least 15 percentiles greater than that before therapy. These studies indicate that testosterone in very low doses resembles "anabolic steroids" in that growth is stimulated without an inordinate androgenic effect. Furthermore, these studies show that institution of low-dose therapy in the early teenage years stimulates pubertal growth normally without loss of height potential.