cssi/SciSciGPT-SciSciNet huggingface dataset:
Global versus specific symptom attributions: predicting the recognition and treatment of psychological distress in primary care.

Abstract Objective Researchers have shown that primary care patients utilize global attribution styles to interpret ambiguous physical symptoms, diminishing the ability of practitioners to recognize psychological disorders. The present study examined the extent to which patients' specific beliefs about their presenting symptoms versus their global symptom attribution styles predict physician recognition of psychological distress and mental health treatment recommendations. Methods Participants included primary care patients attending a five-physician medical practice. Patients completed surveys regarding their level of psychological distress, symptom attribution style, and perceptions of their presenting problems and medical consultations. Physicians completed brief assessments of each patient encounter. Results Patient gender, age, severity of psychological distress, and beliefs about their presenting symptoms were reliable predictors of physician recognition and treatment recommendations. Global symptom attribution styles did not relate to these outcomes above and beyond the specific beliefs of patients. Conclusion Patients' specific beliefs about their presenting symptoms play an important role in predicting physician recognition and treatment of psychological distress.
Multicentre study of the in vitro activity of cefepime, a broad-spectrum cephalosporin, compared to other broad-spectrum agents.

The in vitro activity of cefepime was compared to that of a range of other broad-spectrum agents, using a gradient diffusion MIC method, against 995 recent clinical isolates of Enterobacteriaceae, Pseudomonas aeruginosa, other non-fermentative Gram-negative bacilli, staphylococci (except oxacillin-resistant Staphylococcus aureus), streptococci, enterococci, and aerobic Gram-positive bacilli. Cefepime had excellent activity against Enterobacteriaceae, including eight presumptive extended-spectrum β-lactamase producers and 33 stably derepressed mutants of natural cephalosporinases. Activity against Pseudomonas aeruginosa was similar to ceftazidime and superior to cefpirome. Its activity against Gram-positive cocci was also good, being more active against staphylococci and only slightly less active against streptococci than ceftriaxone. Cefepime maintained activity against bacteria resistant to aminoglycosides and ciprofloxacin. Enterococci, Bacillus species, Burkholderia cepacia and Stenotrophomonas maltophilia were predicably resistant. Cefepime has a spectrum of activity almost as broad as that of the carbapenems.
Improved left atrial transport and function with orthotopic heart transplantation by bicaval and pulmonary venous anastomoses

Orthotopic heart transplantation (OHT) with bicaval and pulmonary venous anastomoses avoids the large atrial anastomoses of the standard biatrial technique. To determine whether the bicaval technique improves atrial performance, we used Doppler echocardiography to study 13 patients with bicaval OHT, 15 with biatrial OHT, and 8 normal subjects. All were in sinus rhythm and free of rejection. Left atrial size, transmitral (M) and late diastolic (A) mitral flow velocity integrals were measured. Atrial transport (A/M, %) and atrial ejection force (kilodynes, calculated from peak A-wave velocity and mitral orifice area) were assessed. Left atrial dimensions in the bicaval (4.3 +/- 0.5 cm) and biatrial groups (4.9 +/- 0.9 cm) were larger than in controls (3.3 +/- 0.8 cm, p < 0.05). Left atrial transport (37% +/- 12% and 35% +/- 12%) and ejection force (14.1 +/- 6.9 kdyne and 10.2 +/- 7.8 kdyne) were similar in the bicaval group and controls (p not significant) but were significantly lower in the biatrial group (20% +/- 19% and 3.6 +/- 4.0 kdynes, p < 0.05). The bicaval and pulmonary venous technique of OHT produces more physiologic atrial function compared with the biatrial technique as evidenced by greater atrial ejection force and more normal atrial transport.
GLOBAL CHANGE AND EMERGING INFECTIOUS DISEASES

Over the past 20 yr we have witnessed epizootics and epidemics involving several pathogenic diseases representing global threats to animal and human health. In the past 5 yr alone epidemiologists and public health workers have been alerted on the ProMed computer site (http://www.promedmail.org) to many human and animal diseases that were transported from one country to another. These included African trypanosomiasis, bovine spongiform encephalopathy (BSE), bovine tuberculosis, brucellosis, campylobacteriosis, cholera, Crimea–Congo hemorrhagic fever, cyclosporiasis, dengue, diphtheria, dracunculus, heartwater, human immunodeficiency virus (HIV) infections, hepatitis types A, B, and E, infectious bovine rhinotracheitis (IBR), influenza A, Japanese encephalitis, Lassa fever, legionellosis, malaria, Newcastle disease, paratyphoid, plague, rabies, Ross River virus infection, shigellosis, trichinellosis, tularemia, typhoid, West Nile fever virus, yellow fever, and yersiniosis. Primarily parasitic diseases, but also a few major diseases caused by other infectious agents, are presented as examples of emerging diseases in the following discussion. Many of these infectious agents and others are vectorborne and ultimately depend for transmission on climatic conditions that are becoming more favorable for the survival of the vectors. The earth’s climate is continually changing. The warming trend of the past 250–300 yr has seen average temperatures approach those of the Medieval Warm Period around the end of the 12th century. Although industrial pollutants were thought to contribute to global cooling recorded in the 1940s through the 1970s, increased atmospheric carbon dioxide and other gases are thought to contribute to a greenhouse effect resulting in the present global warming trend. The past 16 mo have been the warmest in recorded history, and continued warming is forecast. Discussions of the impact of global warming on emerging infectious disease frequently include those diseases associated with tropical climate, such as malaria. Some predictions warn that warmer temperatures will facilitate the spread of malaria and other tropical diseases to Europe and North America, ignoring historical evidence that malaria was once endemic in many temperate regions and that epidemics reached as far as the Arctic Circle. Although the disease is no longer present in most of these areas, the same mosquito vectors remain in many of them, suggesting that temperature is but 1 of many factors influencing disease transmission.
Projections and opinions from 100 experts in long-acting reversible contraception.

Abstract Objective This survey of published researchers of long-acting reversible contraceptives (LARCs) examines their opinions about important barriers to LARC use in the United States (US), projections for LARC use in the absence of barriers and attitudes toward incentives for clinicians to provide and women to use LARC methods. Study design We identified 182 authors of 59 peer-reviewed papers on LARC use published since 2013. A total of 104 completed an internet survey. We used descriptive and multivariate analyses to assess LARC use barriers and respondent characteristics associated with LARC projections and opinions. Results The most commonly identified barrier was the cost of the device (63%), followed by women’s knowledge of safety, method acceptability and expectations about use. A shortage of trained providers was a commonly cited barrier, primarily of primary care providers (49%). Median and modal projections of LARC use in the absence of these barriers were 25–29% of contracepting women. There was limited support for provider incentives and almost no support for incentives for women to use LARC methods, primarily out of concern about coercion. Conclusions Clinical and social science LARC experts project at least a doubling of the current US rate of LARC use if barriers to method provision and adoption are removed. While LARC experts recognize the promise of LARC methods to better meet women’s contraceptive needs, they anticipate that the majority of US women will not choose LARC methods. Reducing unintended pregnancy rates will depend on knowledge, availability and use of a wider range of methods of contraception to meet women’s individual needs. Implications Efforts to increase LARC use need to meet the dual goals of increasing access to LARC methods and protecting women’s reproductive autonomy. To accomplish this, we need reasonable expectations for use, provider training, low-cost devices and noncoercive counseling, rather than incentives for provision or use.
‘Firing Up’ for the Future

My term as president of this great Association will be over in a few days. I suppose I could take this opportunity to wrap up the events of the past three years by telling you about all the great things that have happened—or, in some cases, have not happened. I could remind you of the forward steps we've taken, or talk about the road blocks we have encountered. Many of you might find such a discussion interesting. But that's not my style. As a matter of fact, the past doesn't really turn me on. As for the present, it's there for all to see. So why dwell on it? Don't be alarmed. I know how important our past is. If we don't know where we're coming from, it would obviously be impossible to know where we're going. In the same way, the present is important, too.…
Massive postmortem bronchoconstriction in guinea pig lungs

A special phenomenon (difficult to inflate and deflate) occurring in the postmortem guinea pig lungs was studied in 40 animals. Thirty minutes after excision of the lungs or exsanguination, less than 50% of the lungs could be inflated even at high inflation pressure (34 cmH2O), and most gas was trapped during deflation. The amount of trapped gas volume at 30 min was related to the degree of lung inflation maintained during the 5- to 30-min period after exsanguination. Since stiffness of the lung tissue was unlikely to explain the phenomenon, we speculated airway obstruction as the major factor. No foam or bubbles were found in larger airways and we thus hypothesized that the obstruction was due to bronchoconstriction. This was confirmed histologically in that the lumina of both bronchi and bronchioles were constricted. The latent period to the onset of this constriction was short (approximately 5 min). It was not associated with O2 availability but was delayed an additional 15 min by a thromboxane inhibitor (dazoxiben). Neither maintaining lung temperature at 37 degrees C nor vagotomy and/or cervical transection prevented the constriction. Without exsanguination, onset of bronchoconstriction was delayed by about 1 h. We conclude that postmortem bronchoconstriction may be caused by release of an endogenous constrictor agent.
Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates

The primary psychoactive ingredient of marijuana, Δ(9)-tetrahydrocannabinol (Δ(9)-THC), has medicinal value but also produces unwanted deleterious effects on cognitive function, promoting the search for improved cannabinergic therapeutics. The present studies used a battery of touchscreen procedures in squirrel monkeys to compare the effects of different types of cannabinergic drugs on several measures of performance including learning (repeated acquisition), cognitive flexibility (discrimination reversal), short-term memory (delayed matching-to-sample), attention (psychomotor vigilance), and motivation (progressive ratio). Drugs studied included the cannabinoid agonist Δ(9)-THC, fatty acid amide hydrolase (FAAH) inhibitor cyclohexylcarbamic acid 3-carbamoylbiphenyl-3-yl ester (URB597), and endocannabinoid anandamide and its stable synthetic analog methanandamide [(R)-(+)-arachidonyl-1'-hydroxy-2'-propylamide]. The effects of Δ(9)-THC and anandamide after treatment with the cannabinoid receptor type 1 inverse agonist/antagonist rimonabant [5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1Hpyrazole-3-carboxamide] and the FAAH inhibitor URB597, respectively, also were examined. The results showed the following: 1) Δ(9)-THC produced dose-related impairments of discrimination-based cognitive behavior with potency that varied across tasks (discriminative capability < learning < flexibility < short-term memory); 2) anandamide alone and URB597 alone were without effect on all endpoints; 3) anandamide following URB597 pretreatment and methanandamide had negligible effects on discriminative capability, learning, and reversal, but following large doses affected delayed matching-to-sample performance in some subjects; 4) all drugs, except anandamide and URB597, disrupted attention; and 5) progressive ratio breakpoints were generally unaffected by all drugs tested, suggesting little to no effect on motivation. Taken together, these data indicate that metabolically stable forms of anandamide may have lesser adverse effects on cognitive functions than Δ(9)-THC, possibly offering a therapeutic advantage in clinical settings.
Effects of Binder, Curing Time, Temperature, and Trafficking on Moduli of Stabilized and Unstabilized Full-Depth Reclamation Materials

This paper provides a summary of in situ layer moduli of several full-depth reclamation (FDR) materials used in an accelerated pavement test (APT) track. The reclaimed layers were constructed during the FDR of four lanes of 60 mm of rubberized hot-mix asphalt (HMA), 60 mm of HMA, and 130 mm of aggregate base. The FDR layer served as the base under a new HMA layer. Each lane had a different stabilization strategy, namely, unstabilized, stabilized with foam asphalt plus cement, stabilized with cement only, and stabilized with engineered asphalt emulsion. Falling weight deflectometer testing was conducted on the test track at various times during the course of the study, and the data were used to backcalculate the FDR layer moduli. The results were used to investigate the effects of each stabilization strategy, loading temperature, curing time, and trafficking on the in-place layer moduli of the FDR layers and to provide critical inputs for mechanistic–empirical pavement design of FDR layers.
Negative refraction in Si-based 2-dimensional slab photonic crystal structures

Si-based 2-dimensional slab photonic crystal structures were designed to exhibit negative refraction in the near-infrared region. Negative index imaging was experimentally observed in the integrated device structures including in- and out-coupling waveguides.
Feeding Behavior of Black Cutworms on Seedling Corn and Organic Baits in the Greenhouse

Under greenhouse conditions, late-instar black cutworm, Agrotis ipsilon (Hufnagel), larvae cut significantly more seedling corn plants and fed on more baits under dark conditions than in light. The feeding behavior followed closely the daily solar cycle except when the larvae were kept under dark conditions for 24 h. In the absence of baits, 5th instars fed significantly more often on corn seedlings than did either 4th or 6th instars. Further, 5th and 6th instars cut more than twice as many plants when baits were absent than when baits were present. Highly significant differences occurred between the numbers of larvae recorded feeding in different baits and apple-grape, grape, and bran pellets were the most attractive of all materials tested. Overall, wet bait was preferred to dry, but there were no significant differences between wet and dry soil conditions.
How changes in white matter might underlie improved reaction time due to practice

Why does training on a task reduce the reaction time for performing it? New research points to changes in white matter pathways as one likely mechanism. These pathways connect remote brain areas involved in performing the task. Genetic variations may be involved in individual differences in the extent of this improvement. If white matter change is involved in improved reaction time with training, it may point the way toward understanding where and how generalization occurs. We examine the hypothesis that brain pathways shared by different tasks may result in improved performance of cognitive tasks remote from the training.
An educational model simulating computer-assisted dietetics: “Dietetic Com-Pak”1

An instructional package designed to broaden dietitians’ and dietetic students, working knowledge of computer-assisted food systems management is described.
Fabrication of Coated Polycaprolactone Scaffolds and Their Effects on Murine Embryonic Stem Cells

In the past decade, tissue engineering has become a great interest in materials science research. Embryonic stem (ES) cell transplantation has become one of the most researched therapies for restoring tissue and organ function. Many studies have investigated the use of porous biodegradable scaffolds to promote cell adhesion, growth, proliferation, differentiation, and to help steer the course of tissue development. Research has shown that extracellular matrices and the basement membranes affect various cell types and cellular behaviors. However, the effects of these materials on ES cell behavior are currently understudied and poorly understood. In this study, the synthetic biodegradable polymer polycaprolactone (PCL) was chosen to create an interconnected, fibrous foam structure. A phase separated scaffold method was developed and the product made was coated with various extracellular materials. When the phase separated PCL scaffolds were coated with Matrigel and gelatin solutions, murine ES (mES) cells attached, spread, and differentiated within the scaffolds. There was little growth on the uncoated material. Coating effects on mES cells were analyzed using flow cytometry, reverse-transcriptase polymerase chain reaction and scanning electron microscopy. It was found that coating the scaffold with different extracellular matrices affects mES cell morphology and differentiation. Matrigel coating causes expression of neural proteins and gelatin produces a hepatocyte-like cell.
The Development and Deployment of the Idea of Pornography Addiction Within American Evangelicalism

ABSTRACTBased on an archival analysis of the popular evangelical magazine Christianity Today, the story of evangelical thinking about pornography during the course of the magazine's history from 1956 to 2014 is traced. This article shows how evangelicals have developed and deployed the idea of pornography addiction, and in doing so, have communicated messages about pornography that have made it more likely for evangelicals to perceive themselves as being addicted to pornography. This article investigates the motivations behind these messages, and suggests that these messages may, in fact, tell us less about individual pornography users and more about those who are developing and deploying such messages.
The Power of Cross-Disciplinary Teams for Developing First Responder Training in TBI

Misunderstanding of the symptoms of traumatic brain injury (TBI) often leaves first responders ill-equipped to handle encounters involving subjects with brain injury. This paper details a cross-disciplinary project to develop and disseminate a training curriculum designed to increase first responders’ knowledge of and skills with TBI survivors. The article aims to assist other professionals in understanding the process of working within a cross-disciplinary team to develop and disseminate a training curriculum. Lessons learned based on the development of such a curriculum for first responders working with persons with TBI will be valuable to training coordinators and serve as best practices for implementing similar training programs for specialized learner groups.
The Concept of Realisation

In the early part of this century Martin Buber, whose treatment of I and Thou later brought him into prominence in the English-speaking world, had been deeply attracted to ‘realisation’ as a philosophical idea. It represented a stage in his thinking which he left behind and in consequence of which he was reluctant for an English translation to be published at a time when he was already known for a very different kind of work, that is for his elaboration of a philosophy of dialogue. However Daniel1 is an important book on many counts. First of all, it can be taken as an important example of the ‘new thinking’ which he and some of his contemporaries in the Germany of his day strove to engage in. This would not be cast in an ossified mode shaped by concepts, but would seek to convey the living nerve of thinking on the move, thinking as the very thinker thinks it. It would require a style of writing more familiar in literature than in academic philosophy, and indeed it was not very clear what reading public Buber had in mind when he created this series of dialogues which resemble poetry and drama while at the same time being unmistakably philosophical.
Jay Cooke's Memoir and Wartime Finance

Better known to American history as the gambling robber baron whose failed Northern Pacific Railroad triggered the Panic of 1873, Jay C. Cooke (1821–1905) was the father of modern war finance and a brilliant salesman of the fiscal obligations of citizenship. The son of an Ohio congressman, Cooke moved to Philadelphia in 1839, whetted his appetite for bond sales during the Mexican War, and “on the 1st day of January 1861 in one of the darkest hours of our country” established Jay Cooke & Co. in the heart of Philadelphia’s Third Street financial district. Cooke reflected on his wartime experiences a generation later in an unpublished memoir. Composed in the 1890s with the aid of his granddaughter and now on deposit at the Baker Library Historical Collections of the Harvard Business School, Cooke’s memoir offers invaluable insights into the history of Civil War Pennsylvania.
Radon: A Human Health Hazard in the Environment

Radon is the single major contributor to the ionizing radiation dose, about half of the total radiation exposure, received by the human population and is the second most frequent cause of lung cancer (3–14 % of all lung cancer is attributable to radon) after smoking. Radon was classified as a human carcinogen in 1988 by the International Commission on Radiation Protection, a cancer research agency under the World Health Organization. In this chapter, a historical development of studies related to indoor radon as health hazard is presented. A summary of burden of lung cancer from indoor radon and its progeny is given. Reference level (maximum accepted annual radon concentration in residential dwelling) and Action level (a level above which remedial action is required) for a number of countries are discussed. Factors that affect the indoor radon concentrations along with a mass balance approach for indoor radon in conjunction with the importance of ventilation rate on indoor air radon level is summarized. Key aspects on radon prevention methods and mitigation techniques, including design criteria for radon systems to minimize indoor air radon levels are discussed.
Psychosis: call a surgeon? A rare etiology of psychosis requiring resection

Objective Anti-N-methyl-d-aspartate receptor encephalitis is a rare but emerging cause of autoimmune encephalitis. Our objective is to present a case of this rare disease while highlighting the importance of an aggressive search for underlying malignancy as well as the common mischaracterization of primary psychiatric illness that occurs in these patients. Methods A young Caucasian female with no known psychiatric history presented with acute onset of seizures and psychosis. Results Magnetic resonance imaging abdomen and pelvis showed a 6-mm ovarian teratoma which was not visualized on initial computed tomographic scans. Pathology was consistent with a mature teratoma. Both serum and cerebrospinal fluid N-methyl-d-aspartate receptor antibodies were positive. Conclusion An exhaustive search for underlying malignancy and specifically ovarian teratoma in young women should be completed in these patients. Diagnosis often is delayed given the prominent psychiatric manifestations and providers should be aware and strongly consider this in younger women with acute onset of neuropsychiatric symptoms.
Design and Implementation of an Energy Efficient Multimedia Playback System

Mobile devices capable of multimedia playback have become popular consumer items, making techniques for energy management during multimedia decoding increasingly important. In this paper, we model the multimedia decoding process as a discrete-time system excited by random input sequences representing the incoming stream and therefore, unlike many existing techniques, do not make any assumptions about the workload streams. Using this novel stochastic process model, we can apply formal methods to analyze the decoding system and design a feedback-based on-line dynamic voltage/frequency scaling (DVS) algorithm to effectively reduce the energy consumption during multimedia playback. We implemented our technique in a laptop computer equipped with a DVS enabled processor, and results reveal good performance for real-world video clips across a wide range of video compression formats compared with existing techniques.
A modular mobile robotic system for cooperative payload manipulation

A novel modular ground robotic system is proposed for the purpose of cooperative manipulation and transportation of rigid payloads in two dimensions. The proposed design consists of a set of identical holonomic robots equipped with a lifting mechanism that can be rigidly attached to a desired payload. Once attached, the robot-payload system becomes holonomic and the payload can be transported by the robots along an arbitrary desired trajectory. The proposed system has unique advantages in terms of scalability, holonomic dynamics, and simplicity. Experimental results using a set of prototype robots and an example payload demonstrate feasibility of the proposed system, and trajectory tracking accuracy is quantified using multiple robot configurations. Overall, the proposed modular manipulation system is shown to be a promising technology that is scalable and deployable in a wide range of applications.
C0 Domain of Cardiac Myosin Binding Protein-C Modulates Interaction of the Neighboring C1 Domain with Tropomyosin Through the Allosteric Interaction with F-Actin

Mutations in cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy affecting millions of people worldwide. Recent studies established that the N-terminal domains (NTDs) of cMyBP-C (e.g., C0, C1, M, and C2) can bind to and activate or inhibit the thin filament (TF). However, the molecular mechanism(s) by which NTDs modulate interaction of myosin with the TF remains unknown. Recently, we demonstrated that despite being structural homologs, C0 and C1 NTDs exhibit different patterns of binding on the surface of F-actin. Moreover, we showed that C1 but not C0 can activate the TF by means of shifting the tropomyosin (Tm) cable from the “closed” to the “open” structural state via direct interaction with Tm. Here we used cryo electron microscopy and image analysis to reveal how C0 and C1 Ig-domains connected by the Proline/Alanine-linker communicate with each other when interacting with the TF in tandem. Our results show that C0 binds to the front of actin subdomain-1 in two distinct modes, and that in these two modes C0 has different effect on the interaction of C1 domain with both actin filament and Tm cable. In one mode C0 enhances the activating effect of C1 domain so that the Tm cable is shifted towards the subdomain-4 of actin to an even larger extent than found in the “open” state of Tm. In the second mode C0 reverses the activation effect of C1 by means of disrupting the interaction of C1 with Tm. Importantly, we demonstrate that the two domains communicate with each other allosterically through the actin filament. Our data suggest that the internal dynamics of the actin molecule is essential for the regulation of the actomyosin interaction in cardiac muscle. We propose a mechanism by which cMyBP-C may modulate actomyosin interactions in cardiac muscle.
On Baldrige Core Values and Commitment to Quality

A study compares the perceptions held by supply chain managers and operations managers in regard to the core values of the Malcolm Baldrige National Quality Award. Results show agreement relative to customer-driven quality, creating value, and a focus o..
Treatment of Moyamoya Disease and Unruptured Intracranial Aneurysm in Floating-Harbor Syndrome

Background This is the first report of the successful treatment of moyamoya disease and an unruptured intracranial aneurysm in a patient with Floating-Harbor syndrome. Case Description A 35-year-old, phenotypically syndromic woman presented with signs and symptoms consistent with ischemic stroke. Magnetic resonance imaging and catheter angiography confirmed diagnosis of moyamoya and a 6-mm basilar apex artery aneurysm (BAA). She underwent right-sided craniotomy for direct and indirect revascularization by means of superficial temporal artery-middle cerebral artery bypass and encephalo-duro-arterio-synangiosis. Three months later, she underwent stent-assisted coiling of the BAA. At 9 months, the patient remains without her preoperative neurological deficits. Interval catheter angiography confirms revascularization of her right hemisphere and obliteration of her BAA. Conclusions We present the first case of diagnosis and treatment of moyamoya disease and BAA in a patient with Floating-Harbor syndrome. Due to a paucity of literature on this rare disorder, there has not been an associated link between Floating-Harbor syndrome and cerebrovascular disease. Our report and literature review suggest that these patients may be prone to cerebrovascular disorders and should be followed closely with neurovascular imaging.
Preliminary Investigation of a Stress Prevention and Mindfulness Group for Teachers

This exploratory study evaluated a short-term (6–8 weeks) psychoeducation and support group for teachers focused on stress prevention and mindfulness (labeled SPAM group). A total of 4 groups were implemented in different schools, and evaluation was conducted with quantitative (pre- and post-measures of teacher vulnerability to stress, job satisfaction, and mindfulness) and qualitative (post-intervention interviews) elements using a quasi-experimental mixed methods design. Members reported higher mindfulness scores than participants in the comparison condition, which consisted of teachers in the same school who did not complete the group, and qualitative analyses were supportive of teachers’ satisfaction.
The impact of coworker support and organizational embeddedness on turnover intention among restaurant employees

The hospitality industry continues to thrive, but high rates of turnover still persist within line level employees. Drawing from coworker support and organizational embeddedness, it is hypothesized...
Distributed Mode and Power Selection for Non-Orthogonal D2D Communications: A Stochastic Approach

The coexistence of device-to-device (D2D) and cellular communications in the same band is a promising solution to the dramatic increase of wireless networks traffic load, in particular in the presence of local traffic, when source and destination nodes are in close proximity. In this case, the mobile nodes can communicate in a semi-autonomous way (D2D mode), with minimal or no control by the base station (BS), but they may create a harmful interference to the cellular communications. In order to avoid it, we design a distributed approach that allows the mobile node to acquire in real time local information by observing few channel and topology parameters. Based on this information, each user can infer in advance not only the quality of its transmission, but also its impact on other ongoing surrounding communications toward the BS. This enables a smart, adaptive mode, and power selection performed with a network wide perspective. Differently from most approaches, this selection is made autonomously by each D2D sources, with no need for a centralized scheduling. We compare our strategy to the state-of-the-art in the same distributed network scenario, showing the importance of exploiting local information for a dynamic, interference aware power, and mode selection.
Racial Discrimination and Experience of New Possibilities Among Chinese International Students

The purpose of this study was to examine whether the coping strategies of internalization (e.g., attributing the causes or responsibility of racial discrimination events to oneself) and resistance ...
Image-Guided Percutaneous Biopsy

Image-guided percutaneous biopsy is a commonly ­performed interventional radiological procedure that plays an important role in patient care and management. It is a safe and effective procedure that is less invasive than surgical biopsy and can be performed using a variety of imaging modalities available to most radiologists. Increasingly, referring physicians rely on the expertise and skill of the interventional radiologist to obtain tissue specimens from organ systems within the abdomen and pelvis. Image-guided percutaneous biopsy is associated with low morbidity and mortality, and therefore it can be applied to patients who are too ill to undergo an operation. This chapter reviews the basic principles of image-guided percutaneous biopsy.
Abstract 2620: Aquaporin 11 as a new predictive biomarker of overall survival and platinum-based chemotherapy response in lung adenocarcinoma patients

Background: Biomarkers predictive of response to chemotherapy are critically needed for the precise selection of treatment protocols in lung adenocarcinoma (LUAD). Aquaporins (AQPs), transmembrane water channels, are emerging targets in cancer. Recently discovered, non-ubiquitous family member aquaporin 11 (AQP11), a tissue-specific endoplasmic reticulum (ER) resident, was identified as a cellular pro-survival factor implicated in the maintenance of ER homeostasis. AQP11 is mapped to 11q13-q14 amplicon harboring oncogenic drivers and associated with poor prognosis in cancer patients. We recently showed that high AQP11 expression is an in-vitro therapeutic biomarker of cisplatin therapy, which directly interferes with AQP11 functional structure. In addition, silencing of AQP11 expression in human lung cancer cell lines significantly increased response to cisplatin treatment. We hypothesized that LUAD tumors expressing high levels of AQP11 depend on AQP11-mediated cytoprotection and would be more responsive to platinum-based chemotherapy targeting AQP11. Method: We downloaded and curated matched mRNA expression, survival, and drug response data from The Cancer Genome Atlas (TCGA) LUAD dataset (N=369). Results: Analysis of PRECOG and TCGA databases showed that high AQP11 mRNA expression is negatively prognostic in patients with LUAD. TCGA LUAD cases were categorized by AQP11 mRNA levels into high and low expression (high = AQP11 mRNA expression mean + 1 standard deviation). Patients with high tumor AQP11 mRNA expression (10.3%) had significantly worse overall survival (OS) compared to patients with low AQP11 expression (p=0.0015). An analysis of patients treated with platinum-based chemotherapy (N=74) showed that patients with high AQP11 mRNA expression (7%) had significantly higher OS then patients with LUAD expressing low levels of AQP11 (p=0.0263). Conclusions: This study identifies AQP11 as a new biomarker of OS and chemotherapy in LUAD patients. It is conceivable that lung tumors expressing high levels of AQP11 are dependent on its function and elevated AQP11 expression renders tumor resistance to microenvironment and therapy-induced stress and associates with lower OS of patients. At the same time, as cisplatin efficiently targets AQP11 functional multimeric structure, these AQP11-depending tumors are more prone to platinum based chemotherapy. This study provides a rationale for combination anti-AQP11 and chemotherapy in LUAD tumors with high AQP11 expression. Citation Format: Michael Sharpnack, David P. Carbone, Mikhail M. Dikov, Elena E. Tchekneva. Aquaporin 11 as a new predictive biomarker of overall survival and platinum-based chemotherapy response in lung adenocarcinoma patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2620.
Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia.

Sepsis is a major cause of neonatal morbidity and mortality. The current paradigm suggests that neonatal susceptibility to infection is explained by an innate immune response that is functionally immature. Recent studies in adults have questioned a therapeutic role for IFNβ in sepsis; however, the role of IFNβ in mediating neonatal sensitivity to sepsis is unknown. We evaluated the transcriptional regulation and expression of IFNβ in early neonatal (P0) and adult murine models of endotoxemia (IP LPS, 5 mg/kg). We found that hepatic, pulmonary and serum IFNβ expression was significantly attenuated in endotoxemic neonates when compared to similarly exposed adults. Furthermore, endotoxemia induced hepatic p65/NFκB and IRF3 activation exclusively in adults. In contrast, endotoxemia induced immunotolerant p50/NFκB signaling in neonatal mice without evidence of IRF3 activation. Consistent with impaired IFNβ expression and attenuated circulating serum levels, neonatal pulmonary STAT1 signaling and target gene expression was significantly lower than adult levels. Using multiple in vivo approaches, the source of hepatic IFNβ expression in endotoxemic adult mice was determined to be the hepatic macrophage, and experiments in RAW 264.7 cells confirmed that LPS-induced IFNβ expression was NFκB dependent. Finally, treating neonatal mice with IFNβ two hours after endotoxemia stimulated pulmonary STAT1 signaling and STAT1 dependent gene expression. Furthermore, IFNβ treatment of endotoxemic neonatal animals resulted in significantly improved survival following exposure to lethal endotoxemia. In conclusion, endotoxemia induced IFNβ expression is attenuated in the early neonatal period, secondary to impaired NFκB-p65/IRF3 signaling. Pre-treatment with IFNβ decreases neonatal sensitivity to endotoxemia. These results support further study of the role of impaired IFNβ expression and neonatal sensitivity to sepsis.
Comment on “Solubility determination and correlation of cyromazine in sixteen pure solvents and mixing properties of solutions”

Abstract The numerical values of the logarithm of the infinite dilution activity coefficient, ln γ 1 ∞ , and excess partial molar excess enthalpy at infinite dilution, H 1 E , ∞ , calculated by Zhang and coworkers are not thermodynamically consistent with each other. The calculated values do not obey the standard thermodynamic relationship that the variation in ln γ 1 ∞ with 1/T must be equal H 1 E , ∞ divided by the universal gas constant.
Glottic Stenosis: An Anatomic Analysis and New Treatment With a Self-Retaining Interarytenoid Spring.

Introduction:Endotracheal (ET) intubation is a common cause of acquired glottic stenosis. Severe cases often require an irreversible arytenoidectomy/cordectomy, which typically results in poor voic...
Growth, carcass, and tenderness characteristics of virgin, spayed, and single-calf heifers

Fifty-three Angus/Gelbvieh rotationally crossed heifers were slaughtered after 100 d on a high-concentrate diet. The average slaughter age for each of three different groups was 31, 33, or 35 mo, which falls within the USDA's 30- to 42-mo age range for animals producing "B" maturity carcasses. Each age group consisted of five or six heifers that had never been bred (virgin), six heifers ovariectomized at 1 yr of age (spayed), and six heifers that had weaned calves approximately 120 d postpartum (single-calf). Slaughter weight was higher (P < .05) for the virgin heifers but total weight gain in the feedlot was similar among the three groups. Single-calf heifers fed 100 d after weaning calves tended to be fatter than virgin or spayed heifers. Carcass maturity scores for the single-calf, virgin, and spayed heifers were different (P < .05); single-calf heifers produced carcasses that appeared older and spayed heifers produced carcasses that appeared younger. Maturity scores coupled with lighter and shorter metacarpal bone weights indicated single-calf heifers matured earlier (P < .05) than the other groups. Panel tenderness and Warner-Bratzler (WB) shear values of rib roasts from virgin, spayed, and single-calf heifers were determined. No differences among groups of heifers existed but scores within each group varied greatly. Marbling score was correlated (P < .05) with panel tenderness and shear force and the hydroxylysylpyridinium (HP) crosslink of muscle collagen was correlated (P < .05) with shear values. Because no significant (P < .05) correlation existed between HP in bone collagen or HP or WB shear values in muscle, we concluded that collagen maturation processes in muscle and bone occur independently. With the exception of differences in bone maturity scores, few meaningful differences in characteristics of virgin, spayed, and single-calf heifers existed, but these maturity differences could change carcass grade and influence value.
Model reduction of rigid-body molecular dynamics via generalized multipole potentials.

Motivated by the challenges of uncertainty quantification for coarse-grained (CG) molecular dynamics, we investigate the role of perturbation theory in model reduction of classical systems. In particular, we consider the task of coarse-graining rigid bodies in the context of generalized multipole potentials that have controllable levels of accuracy relative to their atomistic counterparts. We show how the multipole framework yields a hierarchy of models that systematically connects a CG ``point molecule'' approximation to the exact dynamics. We use these results to understand when and how the CG models fail to describe atomistic dynamics at the trajectory level and develop asymptotic error estimates for approximate molecular potential energies. Implications for other model-reduction strategies are also discussed. Key findings of this work are that (i) omitting rotational energy introduces significant error when coarse-graining and (ii) attention to symmetry can improve accuracy of ``point-molecule'' approximations. Analytical derivations and numerical results support these conclusions. Relevance to nonrigid bodies is also discussed.
Doing good while playing: The impact of prosocial advergames on consumer response

Abstract This research explored how a new platform of advergames functions to communicate prosocial initiatives. A 2 (Advergame narratives: with vs. without a prosocial narrative) × 2 (Company placement in games: prominent vs. subtle) between-subject factorial design was employed in an online experiment. A mobile advergame with four conditions was specifically developed as study stimuli. A total of 131 undergraduate student subjects were asked to play an advergame in one of the four conditions and subsequently redirected to an online survey that measured advergame effectiveness (attitudes toward the game, word-of-mouth intention toward the game, and company evaluation). Findings showed that those who played an advergame with a prosocial narrative responded more favorably toward both the game and the company embedded in the game than those who played an advergame without a prosocial narrative. Further, findings revealed that this relationship was mediated by the level of game engagement. In addition, this study found an interaction effect of advergame narratives and company placement on consumer response. In the advergame with a prosocial narrative, participants exposed to a prominently placed company logo evaluated the company more favorably than those exposed to a subtly placed logo did. By comparison, in the advergame without a prosocial narrative, evaluation of the company was more positive in a subtly placed condition than in a prominently placed condition. Implications and suggestions for future research were discussed.
Bourdieu’s Dyad: On the Primacy of Social Space and Symbolic Power

Despite longstanding, intense, and recurring clarifications there are still countless misinterpretations when it comes to the basic principles of Bourdiesian sociology.
Altered excitatory transmission onto hippocampal interneurons in the IQSEC2 mouse model of X-linked neurodevelopmental disease.

Abstract Mutations in the X-linked gene IQSEC2 are associated with multiple cases of epilepsy, epileptic encephalopathy, intellectual disability and autism spectrum disorder, the mechanistic understanding and successful treatment of which remain a significant challenge in IQSEC2 and related neurodevelopmental genetic diseases. To investigate disease etiology, we studied behaviors and synaptic function in IQSEC2 deficient mice. Hemizygous Iqsec2 null males exhibit growth deficits, hyperambulation and hyperanxiety phenotypes. Adult hemizygotes experience lethal spontaneous seizures, but paradoxically have a significantly increased threshold to electrically induced limbic seizures and relative resistance to chemically induced seizures. Although there are no gross defects in brain morphology, hemizygotes exhibit stark hippocampal reactive astrogliosis. Electrophysiological recordings of hippocampal neurons reveal increased excitatory drive specifically onto interneurons, and significant alterations in intrinsic electrical properties specific to the interneuron population. As they age, hemizygotes also develop an increased abundance of parvalbumin-positive interneurons in the hippocampus, neurons in which IQSEC2 is expressed in addition to the excitatory neurons. These findings point to a novel role of IQSEC2 in hippocampal interneuron synaptic function and development with implications for a class of intractable neurodevelopmental diseases.
Bempedoic acid: A promising novel agent for LDL-C lowering

Bempedoic acid (ETC-1002) is a novel, first-in-class, oral, small molecule that inhibits cholesterol biosynthesis in the same pathway as statins, thereby lowering low-density lipoprotein cholesterol (LDL-C) by upregulating LDL receptors. Preclinical and completed Phase II and III clinical trials have demonstrated promising results regarding its safety and efficacy across a variety of patient characteristics including statin intolerance and on a background of lipid-lowering therapy. Bempedoic acid is currently being evaluated in a cardiovascular outcomes trial to evaluate its effect on major cardiovascular events in patients with or at high risk for cardiovascular disease and with statin intolerance. In this review, we will discuss the history and development of bempedoic acid, relevant clinical trials, and its potential role as a lipid-lowering medication in the context of other currently available lipid-lowering therapies.