cssi/SciSciGPT-SciSciNet huggingface dataset:
Incidence and risk factors for symptomatic heart failure after catheter ablation of atrial fibrillation and atrial flutter.

Aims To determine the incidence and risk factors for development of symptomatic heart failure (HF) following catheter ablation for atrial fibrillation (AF) and atrial flutter. Methods and results We prospectively enrolled consecutive patients undergoing pulmonary vein isolation (PVI) or cavotricuspid isthmus (CTI) ablation between November 2013 and June 2014. Post-discharge symptoms were assessed via telephone follow-up and clinic visits. The primary outcome was symptomatic HF requiring treatment with new/increased diuretic dosing. Secondary outcomes were prolonged index hospitalization and readmission for HF ≤30 days. Univariate and multivariable logistic regressions were used to assess the relationship between patient/procedural characteristic and post-ablation HF. Among 111 PVI patients [median age 62.0 years; left ventricular ejection fraction (LVEF) 55%], 29 patients (26.1%) developed symptomatic HF, 6 patients (5.4%) required prolonged index hospitalization, and 8 patients (7.2%) were readmitted for HF. In univariate analyses, persistent AF [odds ratio (OR) 2.97, P = 0.02], AF at start of the procedure (OR 2.99, P = 0.01), additional ablation lines (OR 11.07, P < 0.0001), and final left atrial pressure (OR 1.10 per 1 mmHg increase, P = 0.02) were associated with HF development. Peri-procedural diuresis, net fluid balance, and LVEF were not correlated. In multivariable analyses, only additional ablation lines (ORadj 9.17, P = 0.007) were independently associated with post-ablation HF. Six patients (16.7%) developed HF after CTI ablation. Conclusion A 26.1% of patients undergoing PVI and 16.7% of patients undergoing CTI ablation developed symptomatic HF when prospectively and uniformly assessed. 12.6% of patients experienced prolonged index hospitalizations or readmission for management of HF within 1 week after PVI. Improved understanding of risk factors for post-ablation HF may be critical in developing strategies to address during AF ablation.
Screening? Consider the Clients

The proposal to amend Model Rule 1.10 to allow involuntary screening of lawyers should be defeated. Public trust in the legal professional can only be maintained if client consent is a prerequisite to screening a law firm lawyer.
The Effect of Taper Geometry on Large Head MOM THA Taper-Trunnion Damage

Introduction: Large diameter metal on metal total hip arthroplasty (MOM THA) have shorter lengths of implantation due to increased failure caused by wear either at the articulating surface as well as the taper-trunnion interface. Taper-trunnion wear may be worse in large diameter MOM THA due the increased torque at the taper-trunnion interface. However little has been done to understand how differences in taper-trunnion geometry and trunnion engagement effects wear. The purpose of this study was to (1) measure the differences in taper geometry and trunnion engagement on the head-taper of 11/13, 12/14, and Type 1 taper designs and (2) to determine if taper geometry affects fretting, corrosion, and wear at the taper interface. Methods: We identified 54 MOM THA primary revision implants with head diameters greater than 36 mm from our retrieval archive. Patients9 charts were queried for demographic information and pre-revision radiographs were measured for cup inclination and cup anteversion. To measure taper geometry and wear the head tapers were imaged using Redlux©. The point clouds obtained from this were analyzed in Geomagic©. Taper angles and contact length where the trunnion engaged with the female taper of the head-tapers were measured. The diameter of the taper at the most distal visual area of trunnion engagement was also measured. Best fit cones were fit to the unworn regions to approximate the pristine surface. Differences between the raw data and the unworn surface were measured and volumetric wear rates were calculated. Fretting and corrosion of the head-taper was graded using the Goldberg Scoring. Results: Geometric differences were found between the three designs with the Type 1 being the narrowest with an average taper angle of 3.97 ± 0.09° and an average distal diameter of 12.42 ± 0.35 mm; 11/13 was the second narrowest with a taper angle of 5.97 ± 0.03° and a distal diameter of 13.13 ± 0.27 mm. The widest taper was 12/14 with a taper angle of 5.58 ± 0.21° and a distal diameter of 13.91 ± 0.35 mm. Contact lengths were greatest for 11/13 tapers, 18.96 ± 1.51 mm, then 12/14, 13.31 ± 3.46 mm and least for Type 1, 11.98 ± 4.44 mm (Table 1). Differences in geometry did not significantly affect volumetric wear rate or corrosion but did affect fretting. Type 1 tapers had significantly lower fretting scores (2.9 ± 1.5, p Discussion: We were able to measure determine geometric differences between three common taper designs which may affect taper damage. Tapers which are narrower and have less contact length (i.e. Type 1) had less head-taper fretting than those which are wider and have longer contact lengths. This may be a function of less surface of the trunnion contacting the head taper interface. While we could not demonstrate any differneces in trunnion wear rates among taper types, volumetric wear and corrosion may be independent of taper geometries.
Plant-herbivore interactions

Plants with the C4 dicarboxylic acid pathway of photosynthetic CO2 fixation are generally nutritionally inferior to C3 (Calvin cycle) plants as foodstuff for herbivores. A possible contributing factor to this nutritional inferiority is the concentration, in C4 plants, of large quantities of nutritional material in very tough, thick-walled vascular bundle sheath cells which herbivores may not be able to break down. Experiments with 10 species of grass-hoppers from different areas in the United States revealed large numbers of unbroken bundle sheath cells, contents intact, in fecal pellets produced when the grasshoppers were fed C4 vegetation. We conclude that the material stored in C4 bundle sheath cells is at least partially unavailable to herbivores, and that this may contribute to the observed nutritional inferiority of C4 vegetation.
Gravity gradiometry processing and interpretation at the Kauring Test Site

The Kauring Gravity Gradiometry Test Site offers a unique opportunity to understand the information content of various types of gravity gradient measurements and the required processing and interpretation techniques. In this paper, we utilize the measured ground vertical gravity data to simulate realistic airborne gravity gradiometry data from several current and future systems using an equivalent-source technique. We then invert these simulated data for the underlying density contrast and evaluate the performance of these inversions. The simulated data and inverted models provide a reference for estabilshing the validity of available airborne gravity gradiometry data at the site. The major density features recovered from the optimally converted gradient data are highly consistent with those from the original ground gravity and observed gravity gradient data. The consistency seen in this study demonstrates a coherent understanding of the workflow necessary to process and interpret gravity gradiometry.
Correlation Analysis between Public Basic Courses and Specialized Courses in Higher Vocational Colleges——with Guangdong College of Business and Technology as an Example

This paper points out that the neglect of public basic course teaching is unfavorable to the cultiva-tion of application-oriented talents of high quality. By using the method of canonical correlation analysis for publicbasic course and specialized course of the financial management major in higher vocational colleges, the supportingrole of public basic course to specialized courses is received, and the theoretical reference is provide for curriculum reform in higher vocational colleges.
Analysis of prognosis related factors in surgical practices for hypertensive basal ganglia hemorrhage

Objective To explore the prognostic factors in surgical practices for hypertensive basal ganglia hemorrhage(HBGH).Methods The clinical data of 80 cases of hypertensive basal ganglia hemorrhage were analyzed retrospectively.The correlation of clinical features and the prognosis was analyzed.The prognostic outcomes were assessed according to GOS scale after 6-month follow-up.GOS scores 3-5 were defined good outcomes,and 1-2 scores were defined as poor outcomes.Results Among 80 cases,43 cases achieved good outcomes and 37 cases got poor outcomes.The results of univariate analysis showed that there were 10 variables related to the prognostic outcomes,including preoperative GCS score,volume of the intracerebral hematoma,intraventricular hematoma,brain hernia,surgical ways,operative hemorrhage,residual hematoma,pneumonia,hemorrhage of stress ulcer and electrolyte disturbance.Significant factors selected by univariate analysis were further evaluated by logistic regression analysis with forward stepwise selection procedures.Only 2 predictors showed statistical significance in the multivariate analysis,including brain hernia(P=0.002,OR=9.000,95%CI 2.269-35.701),preoperative GCS scores(P=0.023,OR=1.335,95%CI 1.040-1.715).Conclusion The related factors of operative prognosis could be helpful for doctors to make a correct decision for treating patients with HBGH.
Operative transluminal balloon angioplasty : adjunct to coronary bypass for extended myocardial revascularization of more than 3000 lesions in 1000 patients

Operative transluminal coronary artery balloon angioplasty has been used for over 3000 lesions in 1000 patients since 1980. Initially it was only used for distal stenoses not accessible to coronary bypass grafting in 200 patients. Recatheterization of patients who had intraoperative transluminal balloon angioplasty of the proximal left anterior descending, right, and circumflex coronary arteries 3 years previously revealed excellent patency of both the bypass grafts and the dilated native coronary arteries. This observation supports the thesis that with properly constructed bypass anastomoses competitive flow does not significantly mandate graft thrombosis. Subsequently, intraoperative balloon angioplasty has been performed for both proximal and distal stenoses in 800 patients to improve native coronary artery perfusion and maximize revascularization. Follow-up from 1 to 7 years revealed perioperative myocardial infarction in 21 patients (2.1%) and death in 19 patients (1.9%). Recatheterization from 1 to 7 years after the operation in 51 patients (41 with symptoms) revealed that patency was almost as prevalent in arteries subjected to angioplasty (82%; 137/167) as in bypass grafts (84%; 102/122). Intraoperative balloon angioplasty appears to improve coronary artery perfusion without detrimental competitive flow when used with bypass grafts.
Ways to Provide Quality Physical Activity Courses for College Students

The purpose of this article is to explore ways to improve physical activity courses for college students. To assess student needs, we asked three major questions to 148 students from four different colleges and got results as follows: (1) The most preferred physical activity course was identified as swimming (51.3%) followed by tennis (11.1 %), (2) A swimming facility is needed the most, second to jogging trail, (3) More than a half of the students (49.6%) indicated that they prefer to take classes in the morning between 9:00 a.m. and 12:00 p.m.
Grounding and the Objection from Accidental Generalizations

Monistic grounding says that there is one fundamental ground, while pluralistic grounding says that there are many such grounds. Grounding necessitarianism says that grounding entails, but is not reducible to, necessitation, while grounding contingentism says that there are at least some cases where grounding does not entail necessitation. Pluralistic grounding necessitarianism is a very popular position, but accidental generalizations, such as ‘all solid gold spheres are less than one mile in diameter’, pose well-known problems for this view: the many fundamental grounds of such generalizations do not necessitate them. Though there is a straightforward response to this objection, I argue that it fails. Thus the objection from accidental generalizations stands, and proponents of pluralistic grounding necessitarianism face the following dilemma: either give up pluralistic grounding, or give up necessitarianism.
Enabling efficient multi-channel bonding for IEEE 802.11ac WLANs

In this paper, an analytical model is developed to study the performance of distributed and opportunistic multichannel bonding in IEEE 802.11ac WLANs, with co-existing legacy IEEE 802.11a/b/g users. By modeling the transmissions of legacy users and ac users with and without channel bonding in each channel as a two-level renewal process, the channel bonding probability of ac users in each secondary channel is derived. Based on the bonding probability, the throughput of legacy users and ac users can be analyzed respectively. Our analysis shows that ac users with bonding capabilities achieve higher throughput at the cost of degraded throughput of legacy users. The overall network throughput also decreases due to the increased contention level imposed by ac users in secondary channels. Based on the analysis, we further propose a channel selection scheme for ac users to select the best primary channel, in order to mitigate the contentions in the network and attain the maximal network throughput. Extensive simulations using NS-3 validate the analysis and demonstrate the efficiency of the proposed channel selection scheme.
Transient Melting and Recrystallization of Semiconductor Nanocrystals Under Multiple Electron–Hole Pair Excitation

Ultrafast optical pump, X-ray diffraction probe experiments were performed on CdSe nanocrystal (NC) colloidal dispersions as functions of particle size, polytype, and pump fluence. Bragg peak shifts related to heating and peak amplitude reduction associated with lattice disordering are observed. For smaller NCs, melting initiates upon absorption of as few as ∼15 electron–hole pair excitations per NC on average (0.89 excitations/nm3 for a 1.5 nm radius) with roughly the same excitation density inducing melting for all examined NCs. Diffraction intensity recovery kinetics, attributable to recrystallization, occur over hundreds of picoseconds with slower recoveries for larger particles. Zincblende and wurtzite NCs revert to initial structures following intense photoexcitation suggesting melting occurs primarily at the surface, as supported by simulations. Electronic structure calculations relate significant band gap narrowing with decreased crystallinity. These findings reflect the need to consider the physi...
Do Young Children Really Learn Best From the use of Direct Address in Children’s Television?

A large body of research has considered children’s novel word learning from video; however, no known work has compared children’s novel word learning from an educational television show in which th...
On the Framization of the Hecke Algebra of Type \({\texttt {B}}\)

We give a cross look to two framizations of the Hecke algebra of type \(\mathtt {B}\). One of these is a particular case of the cyclotomic Yokonuma–Hecke algebra. The other one was recently introduced by the author, J. Juyumaya and S. Lambropoulou. The purpose of this paper is to show the main concepts and results of both framizations, giving emphasis to the second one, and to provide a preliminary comparison of the invariants constructed from both framizations.
Masked hypertension and cardiovascular outcomes: an updated systematic review and meta-analysis.

Background As many as one-third of individuals with normal office blood pressure (BP) are diagnosed with masked hypertension (HTN) based on ambulatory BP measurements (ABPM). Masked HTN is associated with higher risk of sustained HTN (SH) and increased cardiovascular morbidity. Methods The present study was designed to systematically review cohort studies and assess the effects of masked HTN compared to normotension and SH on cardiovascular events and all-cause mortality. We systematically searched the electronic databases, such as MEDLINE, PubMed, Embase, and Cochrane for prospective cohort studies, which evaluated participants with office and ambulatory and/or home BP. Results We included nine studies with a total number of 14729 participants (11245 normotensives, 3484 participants with masked HTN, 1984 participants with white-coat HTN, and 5143 participants with SH) with a mean age of 58 years and follow-up of 9.5 years. Individuals with masked HTN had significantly increased rates of cardiovascular events and all-cause mortality than normotensives and white-coat HTN and had lower rates of cardiovascular events than those with SH (odds ratio 0.61, 95% confidence interval 0.42-0.89; P=0.010; I2=84%). Among patients on antihypertensive treatment, masked HTN was associated with higher rates of cardiovascular events than in those with normotension and white-coat HTN and similar rates of cardiovascular events in those with treated SH. Conclusion Prompt screening of high-risk individuals with home BP measurements and ABPM, the diagnosis of masked HTN, and the initiation of treatment, may mitigate the adverse cardiovascular effects of masked HTN.
Trace element diffusion and kinetic fractionation in wet rhyolitic melt

Abstract Piston-cylinder experiments were run to determine the chemical diffusivities of 21 trace elements (Sc, V, Y, Zr, Nb, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, Lu, Hf, Th and U) in hydrous rhyolitic melts at 1 GPa pressure and temperatures from 850 to 1250 °C. Diffusion couple glasses were doped with trace elements in low concentrations to characterize the diffusivities of all cations in a single experiment. Laser ablation ICP-MS was used to evaluate the trace element concentration gradients that developed in the silicate glasses. All calculated diffusion coefficients correspond to the temperature dependence D = D0exp(-Ea/RT). Rhyolite liquids contained either ∼4.1 wt% or ∼6.2 wt% dissolved H2O; separate Arrhenius relationships are produced for each melt composition. Trace element diffusivities in the melt with 6.2 wt% H2O are roughly two times higher than those in the less hydrous melt. Calculated trace element diffusion coefficients cover nearly two orders of magnitude at a given temperature. The high field strength elements are the slowest diffusers, followed by the transition metals and heavy rare earth elements. The light rare earth elements have the fastest diffusion rates in hydrous rhyolitic melt. The measured diffusion coefficients range down to values sufficiently low to preclude diffusive homogenization over geochemically realistic time scales in some cases. The substantial differences in the diffusivities of individual cations may result in fractionated trace element signatures in rhyolite melt pockets. A simple model is used to explore the potential for kinetic fractionation of REE during growth of an apatite crystal in a diffusive boundary layer locally saturated in P2O5. The faster-diffusing light REE are more efficiently transported away from the crystal interface than the slower-moving heavy REE. Diffusion effects will enrich the melt boundary layer in slow-moving HREE relative to the faster LREE. The kinetic fractionation of REE in the melt growth medium will result in a precipitated apatite crystal with a disequilibrium trace element composition.
The Effect of Axon Resealing on Retrograde Neuronal Death after Spinal Cord Injury in Lamprey.

Failure of axon regeneration in the central nervous system (CNS) of mammals is due to both extrinsic inhibitory factors and to neuron-intrinsic factors. The importance of intrinsic factors is illustrated in the sea lamprey by the 18 pairs of large, individually identified reticulospinal (RS) neurons, whose axons are located in the same spinal cord tracts but vary greatly in their ability to regenerate after spinal cord transection (TX). The neurons that are bad regenerators also undergo very delayed apoptosis, signaled early by activation of caspases. We noticed that the neurons with a low probability of axon regeneration tend to be larger than the good regenerators. We postulate that the poorly regenerating larger neurons have larger caliber axons, which reseal more slowly, allowing more prolonged entry of toxic signals (e.g., Ca++) into the axon at the injury site. To test this hypothesis, we used a dye-exclusion assay, applying membrane-impermeable dyes to the cut ends of spinal cords at progressively longer post-TX intervals. Axons belonging to the very small neurons (not individually identified) of the medial inferior RS nucleus resealed within 15 min post-TX. Almost 75% of axons belonging to the medium-sized identified RS neurons resealed within 3 h. At this time, only 36% of the largest axons had resealed, often taking more than 24 h to exclude the dye. There was an inverse relationship between an RS neuron’s size and the probability that its axon would regenerate (r = −0.92) and that the neuron would undergo delayed apoptosis, as indicated by staining with a fluorescently labeled inhibitor of caspases (FLICA; r = 0.73). The artificial acceleration of resealing with polyethylene glycol (PEG) reduced retrograde neuronal apoptosis by 69.5% at 2 weeks after spinal cord injury (SCI), suggesting that axon resealing is a critical determinant of cell survival. Ca++-free Ringer’s solution with EGTA prolonged the sealing time and increased apoptotic signaling, suggesting that factors other than Ca++ diffusion into the injured tip contribute to retrograde death signaling. A longer distance of the lesion from the cell body reduced apoptotic signaling independent of the axon sealing time.
Transapical valve-in-valve replacement of a stenosed prosthetic mitral valve in a critically ill patient with cardiogenic shock: a case report

The burden of managing dysfunctional mitral prosthetic valve disease in the elderly population is increasing for those who cannot tolerate a redo sternotomy along with their multiple comorbid conditions. We report a critically ill elderly patient with a high surgical risk, multiple comorbid conditions, longstanding chronic lung disease, hepatic dysfunction, coagulopathy, acute kidney injury, fluid overload and presenting with cardiogenic shock who was initially rescued with veno-arterial extracorporeal membrane oxygenation and then underwent successful transapical mitral valve-invalve replacement. She survived the procedure and was successfully extubated in the ICU on postoperative day 2. She died on day 5 due to a suspected thrombotic state.
Brain hexokinase, the prototype ambiquitous enzyme.

Publisher Summary The brain is a voracious consumer of glucose—and of oxygen because the predominant route of glucose metabolism is aerobic oxidation via glycolysis and the tricarboxylic acid (TCA) cycle. Under special circumstances that lead to ketosis, ketone body metabolism might contribute to the generation of metabolic energy in the brain, but even under these conditions, an absolute requirement for a basal level of glucose metabolism remains. The critical dependence of normal brain function on an adequate supply of blood-borne glucose and oxygen has been demonstrated. Transport of glucose through the blood-brain barrier is a carrier-mediated process. The principal metabolic pathway involved is glycolysis. Under most conditions, regulation of glucose utilization equates with regulation of glycolysis. The principal control points for cerebral glycolysis are the hexokinase and phosphofructokinase reactions. Brain hexokinase offers a challenging opportunity for understanding how molecular structure and cellular structure might be inter-woven in regulating the in vivo activity of an enzyme of central importance for cerebral energy metabolism.
Antibody localization in horse, rabbit, and goat antilymphocyte sera.

The localization of antibodies was studied in rabbit, goat, and horse ALS raised by weekly immunization with canine or human spleen cells for 4 to 12 weeks. A combination of analytic techniques was used including column chromatography, electrophoresis, immunoelectrophoresis, determination of protein concentration, and measurement of antibody titers. In the rabbit and goat ALS, virtually all of the leukoagglutinins and lymphocytotoxins were in the easily separable IgG; accidentally induced thromboagglutinins were in the same location. In the rabbit hemagglutinins were found in both the IgG and IgM, whereas in the goat these were almost exclusively in the IgM. The antiwhite cell antibodies were most widely distributed in the horse. The cytotoxins were primarily in the IgG, but the leukoagglutinins were most heavily concentrated in the T-equine globulin which consists mostly of IgA. By differential ammonium sulfate precipitation of a horse antidoglymphocyte serum, fractions were prepared that were rich in IgG and IgA. Both were able to delay the rejection of canine renal homografts, the IgA-rich preparation to a somewhat greater degree. The findings in this study have been discussed in relation to the refining techniques that have been used for the production of globulin from heterologous ALS. © 1970.
Distribution of Ions and Water in Epithelial Cells and Tissues

In tight epithelia, such as the toad urinary bladder and the mammalian collecting duct, a brisk transepithelial water flow can be induced by establishing a transepithelial osmotic gradient in the presence of antidiuretic hormone (ADH). Typically, water flow is accompanied by extensive cellular swelling (Peachey and Rasmussen, 1961; Ganote et al., 1968; Kirk et al., 1984) which, unlike swelling which is not caused by transcellular water flow, is largely confined to the apical pole of the epithelial cell while the basal pole is only marginally distended (DiBona et al., 1969). Based on this finding, DiBona (1981) proposed that cytoplasmic water flow induces an intracellular standing gradient of solutes and, therefore, gradient of water activity.
Team Radar: A Radar Metaphor for Workspace Awareness

In distributed software teams, awareness information is often lost due to communication restrictions. Researchers have attempted to retain team awareness by sharing change information across workspaces. The major challenge is how to convey information effectively while avoiding information overload. In this paper, we propose a radar metaphor for distributing and visualizing workspace awareness information. A prototype implementation, Team Radar, is presented and its design is also discussed.
Intraoperative OCT for Uveitis-Related Vitreoretinal Surgery in the DISCOVER Study

Purpose To evaluate the feasibility and usefulness of intraoperative OCT (iOCT) for uveitis-related vitreoretinal surgeries. Design Prospective consecutive case series. Participants Seventy-three consecutive patients (74 eyes) with a uveitis-related diagnosis. Methods Eyes undergoing surgery for a uveitis-related diagnosis in the prospective Determination of Feasibility of Intraoperative Spectral Domain Microscope Combined/Integrated OCT Visualization During En Face Retinal and Ophthalmic Surgery (DISCOVER) iOCT study. Intraoperative OCT was performed at various surgical milestones. Clinical details and evaluation of the role of iOCT were assessed. A standardized surgeon survey was completed to evaluate the usefulness of iOCT during surgery. Main Outcome Measures Percentage of patients in whom iOCT provided valuable feedback and altered surgical decision making. Results Seventy-four consecutive eyes with a uveitis-related diagnosis were enrolled in the DISCOVER study. Successful imaging was obtained in 72 of 73 eyes (98.6%). Intraoperative OCT provided valuable feedback for fluocinolone acetonide implant placement in 11 of 13 eyes (84.6%), for chorioretinal biopsies in 13 of 16 eyes (81.2%), and for retinal detachment (RD) repairs in 20 of 27 eyes (74.1%). In subretinal and chorioretinal biopsies, iOCT altered surgical decision making in 38% of patients. In uveitis-related RD repairs, iOCT resulted in alterations in the surgical procedure in 48% of patients, predominantly related to additional membrane peeling. Conclusion Intraoperative OCT during uveitis-related vitreoretinal surgery seems to provide valuable additional information that can impact surgical decision making and may enhance outcomes.
Derivation of Macrophages from Mouse Bone Marrow

Macrophages are cellular components of the immune system that are essential for responding to pathogens, initiating inflammation and maintaining tissue homeostasis. Isolation, culture, and functional characterization of bone marrow-derived macrophages from mice are exceptionally powerful in vitro techniques used to examine aspects of macrophage biology, including effector functions, such as phagocytosis, cytokine secretion, oxidative burst, migration, and antigen processing and presentation. These studies can be carried out using wild-type, gene-ablated, and/or transgenic mice. The quantity, purity, and ease of culture of these cells enhance their utility for primary cell cultures to understand macrophage biology. Mouse macrophages have become a cognate animal model for the study of human macrophage biology and disease. This chapter outlines protocols used to generate, polarize, quantitate, and functionally evaluate macrophages derived from bone marrow precursor cells.
Journey Into Shame: Implications for Justice Pedagogies

Part of the Adult and Continuing Education and Teaching Commons, Civic and Community Engagement Commons, Community-based Learning Commons, Community-based Research Commons, Curriculum and Social Inquiry Commons, Educational Administration and Supervision Commons, Educational Assessment, Evaluation, and Research Commons, Educational Leadership Commons, Educational Methods Commons, Higher Education Commons, Higher Education and Teaching Commons, Leadership Studies Commons, Liberal Studies Commons, Service Learning Commons, Social and Philosophical Foundations of Education Commons, and the Student Counseling and Personnel Services Commons
A conceptual foundation of design and implementation research in accounting information systems

Abstract This structured literature review focuses on the design and implementation of systems in Accounting Information System (AIS) research. The review has two objectives: 1) To look in depth at AIS research regarding the design and implementation of information systems related to accounting in the last fifteen years; 2) To understand design and implementation issues in AIS. To do so, this research examines the current state of design and implementation research in the domain of AIS, using a structured review of abstracts in top-level Information Systems, Accounting, and AIS journals. Using a design science in IS theoretical framework, the review categorizes themes and trends in AIS literature. Some of the most relevant themes include audit/auditors, enterprise resource planning, monitoring and control, adoption, and decision making. The most relevant issues include training, commitment, investment, culture, and existing business processes. The research includes gaps, limitations, and opportunities for future research.
Truth, Errancy, and Bodily Dispositions in Heidegger’s Thought

Beginning with a discussion of truth and errancy and how these relate to Heidegger’s differentiation between grounding attunements and non-grounding attunements, the essay subsequently brings into discussion the role of the lived body. In order to mark a difference between, on the one hand, fundamental attunements that are disclosive of being and non-being as such and, on the other hand, attunements in so far as they relate to specific things or events and involve our body, the latter are addressed as bodily dispositions. The last part of the essay puts into question that very distinction and suggests that even when it comes to fundamental attunements, these occur through or with bodily dispositions.
Depauperate major histocompatibility complex variation in the endangered reticulated flatwoods salamander (Ambystoma bishopi).

Reticulated flatwoods salamander (Ambystoma bishopi) populations began decreasing dramatically in the 1900s. Contemporary populations are small, isolated, and may be susceptible to inbreeding and reduced adaptive potential because of low genetic variation. Genetic variation at immune genes is especially important as it influences disease susceptibility and adaptation to emerging infectious pathogens, a central conservation concern for declining amphibians. We collected samples from across the extant range of this salamander to examine genetic variation at major histocompatibility complex (MHC) class Iα and IIβ exons as well as the mitochondrial control region. We screened tail or toe tissue for ranavirus, a pathogen associated with amphibian declines worldwide. Overall, we found low MHC variation when compared to other amphibian species and did not detect ranavirus at any site. MHC class Iα sequencing revealed only three alleles with a nucleotide diversity of 0.001, while MHC class IIβ had five alleles with a with nucleotide diversity of 0.004. However, unique variation still exists across this species’ range with private alleles at three sites. Unlike MHC diversity, mitochondrial variation was comparable to levels estimated for other amphibians with nine haplotypes observed, including one haplotype shared across all sites. We hypothesize that a combination of a historic disease outbreak and a population bottleneck may have contributed to low MHC diversity while maintaining higher levels of mitochondrial DNA variation. Ultimately, MHC data indicated that the reticulated flatwoods salamander may be at an elevated risk from infectious diseases due to low levels of immunogenetic variation necessary to combat novel pathogens.
Microblogs: a renewable spatio-temporal fortune

Web users are long-standing sources for rich renewable datasets that are exploited in a wide variety of applications. Such datasets include significant spatial and temporal challenges that shape today's techniques and future technologies in the spatial community. This article highlights microblogs as a renewable source of user-generated data with a great fortune of spatial and temporal information about users, locations, and events that are exploited in rich applications. The articles covers both data management and analysis, discussing some of the existing challenges and future directions.
Discovering the Possible: How Youth Programs Provide Apprenticeships in Purpose

Youth development programs are rich contexts in which teenagers build competencies and begin to gain direction for purpose. Youth in these programs work on projects over weeks or months to achieve meaningful goals (e.g., creating films, painting murals, lobbying public officials). Their high investment in this work helps them learn skills for navigating real-world challenges, achieving goals, and managing the strong emotions that accompany purposeful work. The roles youth hold in programs provide opportunities to enact a moral identity as someone who is responsible to others. These experiences awaken the possibility of purposeful action.
Reducing roadside runoff: Tillage and compost improve stormwater mitigation in urban soils

Abstract Soils adjacent to urban surfaces are often impaired by construction activities that degrade the natural structure and function of the soil, resulting in altered physical, hydraulic, and vegetative properties that limit the infiltration, storage, and filtration of stormwater runoff. A management approach to enhance the efficacy of vegetated roadside soils for runoff control is the use of compost in conjunction with tillage to improve soil conditions and facilitate improved hydrological function, the establishment of vegetative biomass, and increased nutrient and pollutant attenuation. The purpose of this study was to determine the efficacy of soil improvement measures to reduce runoff volumes and improve water quality along roadsides over time. The effects of tillage with and without compost on 1) bulk density and infiltration rates, 2) runoff volumes, and 3) runoff water quality were evaluated during multiple storm events along two long-established interstate roadsides in North Carolina during 2015 and 2017. Experimental plots were established in the grassed areas adjacent to roads and consisted of an untreated control, tillage only, and tillage amended with compost. Tillage alone did not reduce runoff in roadside soils, however, tillage with compost did improve runoff capture. The patterns in hydrologic performance within and among sites suggests that the incorporation of compost in tilled soils may influence storage potential through different effects on soil properties, such as decreasing bulk density or improving vegetation establishment, thereby increasing evapotranspirative withdrawals, depending on soil texture. Tillage increased sediment concentrations in runoff, however, net export of sediments was reduced with the inclusion of compost due to the reduction of runoff quantities compared to undisturbed areas and tillage alone. Control and treatment plots were equally effective in reducing dissolved nutrient and metal concentrations, however, the improved hydrologic performance in plots with compost decreased net nutrient and metal export in most storms. The results of this study suggest that the incorporation of compost in compacted urban soils may provide significant improvements for biological and physical soil properties that affect stormwater interception and infiltration.
Understanding care transition notifications for chronically ill patients

Chronically ill patients may be at risk of re-hospitalization or even death if their care transitions are poorly coordinated. Transitions of care create challenges for care coordination, such as in...
Technology of continuous professional training of future specialists in navigation and sea vessel management at higher maritime educational institutions

The article substantiates the technology of continuous professional training of future specialists in navigation and management of sea vessels in higher maritime educational institutions and the results of experimental testing of its effectiveness. Pedagogical conditions that have a cross-cutting impact and should be implemented during all four stages have been also determined. To test the effectiveness of the author's technology, a study was conducted, which involved students who studied at the first (Bachelor's) and second (Master's) levels of higher education in higher maritime educational institutions. Comparison of the results of the state of formation of readiness of future specialists in navigation and management of sea vessels for professional activity in Control and Experimental groups using mathematical statistics methods showed that obtained qualitative and quantitative characteristics have reliable differences in favor of experimental groups, which indicates the effectiveness of the author's technology.
The Impact of “Soft” Affirmative Action Policies on Women and Minority Demographics, Hiring, Promotion, Attrition, and Leadership in Law Firms: The “Mansfield Rule”

In 2016, inspired by the NFL’s Rooney Rule, the Mansfield Rule was devised to push soft affirmative action policies, including the so-called 30% rule, to incentivize law firms to affirmatively consider women and underrepresented groups for leadership and governance roles, equity partner promotions, and lateral positions. To determine the effectiveness of the Mansfield rule I carried out an empirical study that compares those firms that have adopted the Mansfield rule with law firms that have not. Using a Mann Whitney Wilcoxon test, I compared the deviation in the demographics, recruitment, attrition, promotion, and committee compositions, including leadership composition, between firms that have been Mansfield-certified, the “treatment group”, with the analogous deviation for a “comparison-control group” that did not opt for the Mansfield Rule application. I did so for the years 2007-2019. The findings show that the overall population of all law firms and the diversity proportion within the population show an increase from 2007 to 2019, irrespective of the treatment. Furthermore, the treatment had no statistically significant effect on either the growth rate evolution or the predictability of law firms’ behavior related to recruitment, attrition and promotion and committee composition. These results indicate that applying the Mansfield rule has no measurable impact on the diversity proportion of the population of the firm, its growth rate, or its predictable behavior related to their firm’s diversity.
Jurisidiction to Adjudicate and Jurisdiction to Prescribe in International Criminal Courts

Direct jurisdiction over individuals, along with responsibilities to them, are outstanding characteristics of the new International Criminal Court (ICC or Court), as they already are of the International Criminal Tribunals for the Former Yugoslavia (ICTY) and for Rwanda (ICTR). This Article raises issues of legitimate power to prosecute and to define criminal law and issues of individual human rights which necessarily arise in any criminal system. This Article is predominantly an analysis of issues of criminal jurisdiction over persons as they are treated in the ICC Statute, as well as in the current ad hoc international criminal tribunals. Part II discusses the sources of international criminal tribunals’ jurisdiction to prescribe from the end of World War II through the proposal of the ICC Statute. Part III describes the limited jurisdiction to adjudicate over individuals in the ICTY and ICTR. Part IV discusses the ICC Statute’s general statement of and limits on jurisdiction to adjudicate over individuals. The subsequent Parts examine personal jurisdiction in the three classes of cases, defined by the manner in which a situation comes before the ICC, as set out in the ICC Statute. Part V addresses two of these, jurisdiction to adjudicate where a situation is referred to the Court by a State or where an investigation is initiated by the prosecutor proprio motu. Part VI addresses personal jurisdiction in situations referred to the ICC by the United Nations (U.N.) Security Council. These latter two Parts necessarily address jurisdiction to prescribe criminal law, as well as jurisdiction to adjudicate allegations of crime, because situations covered by the ICC Statute may involve nationals of States not parties to the ICC Statute, that have not accepted the Court’s jurisdiction.
Biohydrogenation of Unsaturated Fatty Acids III. PURIFICATION AND PROPERTIES OF A LINOLEATE Δ12-CIS,Δ11-TRANS-ISOMERASE FROM BUTYRIVIBRIO FIBRISOLVENS

Abstract Incubation of Butyrivibrio fibrisolvens with linoleic acid produced a conjugated dienoic acid which was identified as cis-9,trans-11-octadecadienoic acid. When linolenic acid (Δ9,12,15) was used as substrate, it also was isomerized to a conjugated acid which was tentatively identified as cis-9,trans-11,cis-15-octadecatrienoic acid. Subsequent hydrogenation of this conjugated trienoic acid produced a nonconjugated cis,trans-dienoic acid but no monoenoic acid. Incubation of whole bacteria with linoleic acid in D2O produced cis-9,trans-11-octadecadienoic acid which contained a single deuterium atom at C-13. A spectrophotometric assay was developed for the presence of linoleate Δ12-cis,Δ11-trans-isomerase, an enzyme localized in the cell envelope. The enzyme did not require the addition of nucleotide cofactors or the presence of a hydrogen atmosphere. The Km for linoleic acid was 1.2 x 10-5 m, and for linolenic acid it was 2.3 x 10-5 m. The average equilibrium constant for the isomerization of linoleic acid was 61 when measured from the forward and reverse directions.
Gamma-secretase inhibitors: Notch so bad

γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with glucocorticoids could provide a more effective and safer approach (pages 50–58).
A recent radical graphical approach to programming

This paper provides a very brief overview of the history of graphical approaches to programming. A more detailed description is given of SoftWIRE, a recent radical graphical approach to programming, which has much potential. SoftWIRE utilizes Visual Basic (VB) in the Integrated Development Environment (IDE) Microsoft Visual Studio. NET. The description of SoftWIRE provides details, advantages, and program examples. Predictions are made on the development and the future of graphical programming and also on a possible shift to using a graphical-oriented paradigm to teach programming. A sample course description and outline using SoftWIRE and a graphical approach for Computer Science I (Introduction to Problem Solving and Programming) is given in the Appendix.
The locations of nonresidential out-of-hospital cardiac arrests in the City of Pittsburgh over a three-year period: implications for automated external defibrillator placement.

Objectives. To determine the locations of nonresidential out-of-hospital cardiac arrests (OHCAs) in the City of Pittsburgh and to determine whether there are “high-risk” locations that might benefit from placement of automated external defibrillators (AEDs). Methods. This was a retrospective case review of paramedic calls for OHCA over a three-year period, in a mid-sized northeastern city. Cardiac arrests that were traumatic or for which the patients were dead on arrival (DOA) or had advanced directives for no resuscitation were excluded. Cardiac arrests that occurred in a public location (i.e., not a private residence) were categorized. Results. A total of 971 OHCAs occurred in the City of Pittsburgh from January 1, 1997, to December 31, 1999. Of these, 575 (59%) occurred in private residences, and 396 (41%) occurred in nonresidential locations. Fifteen locations had at least one cardiac arrest per year for three years, accounting for 166 (43%) of the total nonresidential OHCAs. Twelve locations had two ...
The precipitating cloud population of the Madden‐Julian Oscillation over the Indian and west Pacific Oceans

[1] The variability of the precipitating cloud population of the Madden-Julian Oscillation (MJO) is represented by statistics of echo features seen by the Tropical Rainfall Measuring Mission's Precipitation Radar over the central Indian and west Pacific Oceans. Echo features include isolated shallow echoes, deep convective cores, wide convective cores, and broad stratiform regions. Isolated shallow echoes are ever present but most numerous during suppressed MJO phases. Broad stratiform regions dominate variability in areal coverage and maximize during active phases. Deep convective and wide convective cores are more common and variable in number than broad stratiform regions. The magnitude of variability is similar in both regions. In the central Indian Ocean, active MJO phases have synchronous maximization of deep convective entities. In the west Pacific, broad stratiform regions maximize prior to wide convective cores. Reanalysis indicates that isolated shallow echoes are most numerous in dry mid-tropospheric conditions and strong low-level (1000–750 hPa) shear. Mid-tropospheric moisture increases before deeper convective features increase in number, maximizes as deep convective features maximize, and decreases as wide convective cores and broad stratiform regions decline in population. Active-stage deep and wide convective cores occur preferentially with moist mid-tropospheric conditions and strong low-level shear. Acute shear may favor downdraft momentum transport and consequently more robust gust-front convective triggering. Broad stratiform regions maximize with a moist mid-troposphere, strong low-level shear, and moderate upper-level (750–500 hPa) shear that is not so strong that the stratiform region disconnects from its convective moisture source.