cssi/SciSciGPT-SciSciNet huggingface dataset:
Analysis on Economic Operation of Energy Storage Based on Second-Use Batteries

The recycling of batteries that were out of service is one of problems urgently needed to be solved for sustainable development of new energy resources. Based on the combination of energy storage system composed of second-use batteries with high-power fast charging station, an optimal capacity allocation method of fast charging station, in which the second-use of electric vehicle(EV) batteries is taken into account, is proposed. According to typical load of fast charging station and based on synthetical analysis on the cost for the construction, operation and maintenance of energy storage system composed of second-use batteries and considering the revenue from standing over the upgrading and renovation of distribution network and the economic value from the revenue due to reducing network loss and peak load shifting, an economic benefit model of the energy storage system composed of second-use batteries is established and solved by genetic algorithm. Cast study results show that allocating energy storage system composed of second-use batteries in EV fast charging station can reduce the capacity of the transformer and bring economic benefit for power grid enterprises.
216 EFFECT OF DIALYSIS CATHETER DESIGN ON RECIRCULATION RATE

Background Unfortunately, cuffed tunneled catheters (CTC) have become an integral part of hemodialysis and many designs have been developed to achieve optimal performance and longevity. The ideal catheter design would have low recirculation values, high blood flow rates and better biocompatibility. Recirculation rate (RR) may vary with catheter design and worsen with reversal of ports. Even though reversal of ports is not recommended, it is frequently relied upon to provide dialysis support. The aim of this study was to measure blood flow recirculation with standard and reverse connection using two different catheter designs (AshSplit II and Arrow Cannon). Methods We retrospectively reviewed the performance of 12 catheters that were placed in the interventional suite. All CTC were placed in right internal jugular (IJ) vein by the same nephrologists under fluoroscopy. The RR was calculated using Crit-LineIII optical monitor on first CTC use after insertion, by the same operator, at blood flow rates (Qb) of 300 mL/min and 400 mL/min in standard (≠) and reverse connection (↓). Results RR are listed in the table below (expressed as mean % ± SD. The venous pressure (VP) simultaneously measured were AshSplit II 150 ± 50 mm Hg (Qb300 mL/min) and 190 ± 50 mm Hg (Qb400 mL/min); VP with Arrow Cannon 164 ± 60 mm Hg (Qb300 mL/min) and 225 ± 175 mm Hg (Qb400 mL/min). VP was not different during reverse connection. Conclusion Recirculation rates were identical with both catheter designs using standard connection. However, AshSplit II catheter design favors low recirculation compared to Arrow Cannon when connections are reversed. Discussion Difference in the CTC tip design possibly plays a role in the observation noted in our study. Spatial distance between arterial and venous end with V-tip design of Arrow Cannon probably creates more turbulence compared to the Tip hole design of AshSplit II, resulting in higher recirculation rates with reverse connection.
An Investigation on Infection of Lyme Disease in Person and Tick Vectors in Xiamen

Objective To study the person infection and tick vectors of Lyme disease in Xiamen. Methods Indirect fluorimetry antibody(IFA) was used to detect serum IgG antibody of Lyme disease among population. In addition, polymerase chain reaction(PCR)test was used to detect pathogen DNA fragment maybe taken along in tick. Results Out of 239 persons, the IgG antibody was positive in 5 persons' sera. The positive rate was 2.09%. 499 tick vectors detected were all negative. Conclusion For the first time, the Lyme disease Leptospira in persons' sera has been detected, and which approves that there are infected persons of Lyme disease in Xiamen.
U-stitch ureteroneocystostomy: A new renal transplantation ureteral reimplantation technique associated with reduced urologic complications

Urologic complications represent the most frequent complications following renal transplantation and are associated with significant morbidity. We present the results of the first 105 patients who underwent ureteroneocystostomy at our institution using a new surgical ureteral reimplantation technique designed to reduce the incidence of urologic complications after renal transplantation.
A practical synthesis of N-alkyl- and N,N′-dialkyl-polyamines

Abstract A variety of polyamines have been synthesized from their corresponding amino alcohols through a 3-step process. The synthesis predicates that the most likely impurities are of higher molecular weight and that distillation is effective at producing highly pure materials. This sequence is scalable, requires no protecting groups or chromatography, and provides the requisite polyamines in moderate to good yields.
Surgical management of occluded conduits after the Fontan operation in patients with Glenn shunts

Five complete conduit occlusions occurred in four patients with the Glenn shunt 2 months to 2 years after the Fontan operation. The possible reasons for complete conduit occlusion were severe dehydration, high pulmonary vascular resistance, and intraoperative manipulation of the conduit. In one patient in whom complete conduit occlusion developed twice, no possible cause could be identified. Surgical approaches included replacement of the occluded conduit in three patients and creation of an atrial septal defect and left aortopulmonary shunt in the fourth patient. All patients who had replacement of the occluded conduit survived. The fourth patient had severe cyanosis and hypoxemia from marked reduction of flow through the Glenn shunt because of reversal of flow through large venous collaterals. He subsequently died of Candida sepsis. A fifth patient (previously reported) who had complete conduit occlusion also died after a similar procedure. We believe that in patients with a Glenn shunt who develop complete conduit occlusion after the Fontan operation, conduit excision and a secondary Fontan operation, preferably without the use of woven Dacron, should be done instead of establishing an atrial septal defect and aortopulmonary shunt to the left lung.
Azimuthal and Radial Variation of Wind-Generated Surface Waves inside Tropical Cyclones

AbstractFor wind-generated waves, the wind-wave triplets (reference wind speed, significant wave height, and spectral peak wave period) are intimately connected through the fetch- or duration-limited wave growth functions. The full set of the triplets can be obtained knowing only one of the three, together with the input of fetch (duration) information using the pair of fetch-limited (duration limited) wave growth functions. The air–sea energy and momentum exchanges are functions of the wind-wave triplets, and they can be quantified with the wind-wave growth functions. Previous studies have shown that the wave development inside hurricanes follows essentially the same growth functions established for steady wind forcing conditions. This paper presents the analysis of wind-wave triplets collected inside Hurricane Bonnie 1998 at category 2 stage along 10 transects radiating from the hurricane center. A fetch model is formulated for any location inside the hurricane. Applying the fetch model to the 2D hurric...
Investigating the Relationship between School Level and a School Growth Mindset

This study explored the relationship between school level and the psychosocial construct of a growth mindset school culture. Data was collected on the What’s My School Mindset (WMSM) Survey from a stratified random sample of PK-12 faculty and administrators (n = 347) in 30 schools across a large northwestern state. The overarching research question was, “Is there a relationship between school level and a school’s growth mindset?” Results revealed a significant decrease in the WMSM mean between elementary school level and high school level participant self-reports. Therefore, the results of this study could be used to create opportunities for faculty dialogue and reflection to changes perspectives, inform future practice, provide realistic ways to implement change by using research-based evidence to challenge assumptions; and give sound reasons for new practices.
Evidence-Based Medicine

Evidence-based medicine (EBM) and the development of best practice guidelines empower the modern physician to deliver high-quality care to his or her patients. EBM fosters the diagnosis and treatment of disease according to the strongest scientific evidence, and has the potential to not only improve clinical outcomes but also lower health care costs [1–4]. Evidence-based protocols have shortened duration of intensive care unit and overall hospital stay [4], reduced rates of central venous catheter-associated bloodstream infections up to 66 % [2], and stimulated the alcohol-based hand sanitizer intervention to curtail spread of multi-drug-resistant organisms in hospitals [5]. In fact, some argue that “evidence-based medicine has come to define what is rational in medical practice, with implications for both standardization and reimbursement” [3]. Concurrently, factors such as expanding performance measures [6] and the growth of accountable care organizations have cemented clinical research and evidence-based medicine as “a necessity for practitioner autonomy and economic survival” [7]. Certainly as the landscape of physician reimbursements shifts toward pay-for-performance, accessibility to and an understanding of best practice guidelines are essential to any clinician.
A reliable sealing method for microbatteries

Abstract As electronic devices continue to become smaller, their energy sources (i.e., batteries) also need to be smaller. Typically, energy densities of batteries decrease as the battery size decreases due to the relative increase of parasitic weight such as packaging materials. In addition, the sealing methods in conventional batteries are difficult to apply to microbatteries. In this work, we developed a facile sealing method for microbatteries. The method employs a dual-sealing concept: a first rubber barrier temporally confines the organic electrolytes and a second adhesive barrier forms a hermetic seal with the battery case. With this innovative sealing approach, excellent shelf life and operation life of the batteries have been demonstrated. A minimal amount of packing materials is employed resulting in high energy densities.
Alkene Isomerization by “Sandwich” Diimine-Palladium Catalysts

In contrast to traditional diimine-palladium complexes, sterically hindered “sandwich” diimine-palladium adducts act as olefin isomerization catalysts. Terminal olefins are selectively converted to 2-olefins by a sequence of migratory insertion, β-hydride elimination, and olefin displacement. The reaction is performed at 0 °C with 1 mol % of an air-stable precatalyst and tolerates functional groups such as ketones, silyl ethers, and halogens. The isomerization may be used to produce silyl enol ethers from protected allylic alcohols.
UTILIZATION OF DISTAL EMBOLIC PROTECTION IN INFRAINGUINAL PERIPHERAL ARTERIAL INTERVENTION: INSIGHTS FROM THE MULTICENTER XLPAD REGISTRY

Background: Distal embolization (DE) is a serious complication of lower extremity peripheral vascular interventions (PVI). Although, embolic protection devices (EPD) mitigate the risk of DE, there is a paucity of data on the use of EPDs during PVI. Methods: We analyzed data from the multicenter
Somatostatin depresses the excitability of subicular bursting cells: Roles of inward rectifier K+ channels, KCNQ channels and Epac

The hippocampus is a crucial component for cognitive and emotional processing. The subiculum provides much of the output for this structure but the modulation and function of this region is surprisingly under-studied. The neuromodulator somatostatin (SST) interacts with five subtypes of SST receptors (sst1 to sst5 ) and each of these SST receptor subtypes is coupled to Gi proteins resulting in inhibition of adenylyl cyclase (AC) and decreased level of intracellular cAMP. SST modulates many physiological functions including cognition, emotion, autonomic responses and locomotion. Whereas SST has been shown to depress neuronal excitability in the subiculum, the underlying cellular and molecular mechanisms have not yet been determined. Here, we show that SST hyperpolarized two classes of subicular neurons with a calculated EC50 of 0.1 μM. Application of SST (1 μM) induced outward holding currents by primarily activating K+ channels including the G-protein-activated inwardly-rectifying potassium channels (GIRK) and KCNQ (M) channels, although inhibition of cation channels in some cells may also be implicated. SST-elicited hyperpolarization was mediated by activation of sst2 receptors and required the function of G proteins. The SST-induced hyperpolarization resulted from decreased activity of AC and reduced levels of cAMP but did not require the activity of either PKA or PKC. Inhibition of Epac2, a guanine nucleotide exchange factor, partially blocked SST-mediated hyperpolarization of subicular neurons. Furthermore, application of SST resulted in a robust depression of subicular action potential firing and the SST-induced hyperpolarization was responsible for its inhibitory action on LTP at the CA1-subicilum synapses. Our results provide a novel cellular and molecular mechanism that may explain the roles of SST in modulation of subicular function and be relevant to SST-related physiological functions.
Intersection between biodiversity conservation, agroecology, and ecosystem services

ABSTRACTAgroecological research has improved our understanding of the drivers and benefits of biodiversity, thus providing the scientific basis needed to achieve agricultural multifunctionality. We review how agroecology has contributed to our understanding of the effects of local and landscape level drivers on beneficial insects, as well as on the ecosystem services they provide. Several syntheses from agroecosystem research indicate that both populations and biodiversity of pollinator and natural enemies decline with increases in local agricultural intensification and that landscape composition and configuration may mediate these local scale effects. Changes in agricultural management may affect predation and pollination services by altering the resource base for natural enemies and pollinators, by altering their species pool, and by modifying their interactions. The effects of these drivers depend on taxonomical or functional groups and landscape context. Studies that directly measure the cascading eff...
Positive and Negative Affect More Concurrent among Blacks than Whites.

Background: While positive and negative affect are inversely linked, people may experience and report both positive and negative emotions simultaneously. However, it is unknown if race alters the magnitude of the association between positive and negative affect. The current study compared Black and White Americans for the association between positive and negative affect. Methods: We used data from MIDUS (Midlife in the United States), a national study of Americans with an age range of 25 to 75. A total number of 7108 individuals were followed for 10 years from 1995 to 2004. Positive and negative affect was measured at baseline (1995) and follow-up (2004). Demographic (age and gender), socioeconomic (education and income) as well as health (self-rated health, chronic medical conditions, and body mass index) factors measured at baseline were covariates. A series of linear regressions were used to test the moderating effect of race on the reciprocal association between positive and negative affect at baseline and over time, net of covariates. Results: In the pooled sample, positive and negative affect showed inverse correlation at baseline and over time, net of covariates. Blacks and Whites differed in the magnitude of the association between positive and negative affect, with weaker inverse associations among Blacks compared to Whites, beyond all covariates. Conclusion: Weaker reciprocal association between positive and negative affect in Blacks compared to Whites has implications for cross-racial measurement of affect and mood, including depression. Depression screening programs should be aware that race alters the concordance between positive and negative affect domains and that Blacks endorse higher levels of positive affect compared to Whites in the presence of high negative affect.
A Novel Class of Test Problems for Performance Evaluation of Niching Methods

This paper proposes a novel procedure for generating parametric scalable functions with diverse properties to strengthen numerical evaluation of niching methods. It combines three simple basic functions to form a composite multimodal function, in which the function parameter controls the number of global minima. The resultant composite function may show a variety of challenges in global optimization such as high condition, correlation, and presence of many undesirable local minima, as well as those peculiar to multimodal optimization, such as nonuniformly distributed global minima with dissimilar basin sizes. Moreover, the proposed procedure results in computationally inexpensive composite functions, when compared to those generated by available methods. This allows for benchmarking long-term success of niching methods on problems with many global minima. Six parametric benchmark functions are proposed in which the function parameter controls the number of global minima. Detailed analysis on distribution, basin shapes and sizes of the global minima is provided. One of the proposed test problems involve constraints, a matter which did not receive much attention in the past. These test functions are employed to compare some of the most successful niching methods in the literature. The numerical results disclose a drastic disparity between the performance of different niching methods on the composite functions and the existing test problems, demonstrating that the proposed composite functions simulate distinct challenges. Our findings highlight importance of the core search algorithm and challenge suitability of many niching strategies in more complicated landscapes and higher dimensions.
Exploring the Relationship of Scratch Resistance, Hardness, and other Physical Properties of Minerals using Mohs Scale Minerals

The Mohs scale is enshrined in geoscience curricula as a simple and effective tool for identifying minerals and understanding the influence of crystal structure and chemistry on physical properties; e.g., hardness. Measuring scratch resistance is different from measuring hardness, however, because scratching involves components of loading and shearing, whereas "absolute" hardness is measured by the response of a material to vertical loading (indentation). Although it is not practical for most undergraduate classes to do indentation hardness testing, students can evaluate tabulated quantitative hardness data and compare these data with their own determination of relative scratch resistance. To help students better understand physical properties of minerals, and in particular the concept of mineral hardness, we present an example exercise based on recent systematic measurements of the hardness of Mohs scale minerals using indentation techniques. This exercise allows students to explore the differences in hardness among minerals of the Mohs scale, enhancing their understanding of the Mohs scale itself as well as the chemical and physical factors that influence mineral hardness. The exercise is most appropriate for Earth materials and mineralogy classes, but can be adapted for students with different levels of expertise, including introductory physical science students.
The Apolipoprotein E Cys-142 Mutant: Role in Dominant Inheritance of Type III Hyperlipoproteinemia and Expression in Transgenic Mice

Type III hyperlipoproteinemia (HLP) is a genetic disorder of lipid metabolism in humans in which the primary molecular defect is a mutation(s) in apolipoprotein (apo) E that causes defective interaction of apoE with lipoprotein receptors and an accumulation of cholesterol-rich β-VLDL in the blood (Mahley and Rall, 1989). Most often, type III HLP is associated with homozygosity for an apoE mutant that has cysteine instead of arginine at residue 158, i.e., with recessive inheritance. Many rare mutants of apoE have now been described (Fig. 1), some of which are also associated with type III HLP. In most of these rare instances, type III HLP is transmitted in a dominant fashion, i.e., heterozygosity for the apoE mutant is sufficient for expression of the disorder. One of these rare apoE variants (cysteine instead of arginine at residue 142) has been found in a single family in which seven members spanning four generations are heterozygous for this apoE variant and all seven have type III HLP (Havel et al. 1983; Rall et al. 1989). Because of the unusual nature of the disorder in this family, we undertook investigations of the properties of the apoE Cys-142 mutant to determine its role in the expression of type III HLP.
Computer Science and Philosophy

“Computer science and philosophy? Isn’t that sort of an odd combination?” Such is the typical cocktail-party response when learning of my academic training in the discipline Socrates called “the love of wisdom” and my subsequent immersion in the world of bytes, programs, systems analysis, and government contracts. And such might very well be the reaction to the title of this essay. But despite its cloistered reputation, and its literary, as opposed to technological image, the tradition of philosophical investigation, as all of us who have been seduced by it know, has no turf limits. No turf limits, at least, in one direction; while few but the truly prepared venture into philosophy’s hard-core: “inner circle” of epistemology, metaphysics, (meta)ethics, and logic, literally anything is fair philosophical game in the outer circle in which most of us exist. And so we have the “philosophy of’s”: philosophy of science, philosophy of art, of language, education. Some of the philosophy of’s even have names befitting their integration into vital areas of modern society, for example, medical ethics and business ethics, which we can say are shorter names for the philosophies of ethical decisions in medicine and business. This anthology is intended to be perhaps the first organization of various writings in a yet-to-crystalize philosophy of comouter science.
Bone marrows of non-Hodgkin's lymphoma patients with a bcl-2 translocation can be purged of polymerase chain reaction-detectable lymphoma cells using monoclonal antibodies and immunomagnetic bead depletion

Using the extremely sensitive technique of polymerase chain reaction (PCR) to detect the bcl-2 translocation, only 50% of bone marrows could be purged of PCR-detectable lymphoma cells using a cocktail of three anti-B-cell monoclonal antibodies (MoAbs) and complement-mediated lysis. This observation is of clinical importance because those patients whose reinfused marrows harbored residual lymphoma cells showed a significantly increased incidence of relapse. To improve purging, we used PCR detection of the bcl-2 translocation to compare the efficiency of complement-mediated lysis with immunomagnetic bead depletion. Using either a three or a four MoAb cocktail followed by immunomagnetic bead depletion, all PCR-detectable cells were purged after three cycles of treatment. In these same patient samples, treatment with three MoAbs and complement purged only 11 of the 25 (44%) samples. The addition of a fourth MoAb followed by complement lysis purged the marrows of only an additional five patients. Immunomagnetic bead depletion was specific because there was no loss of committed myeloid progenitor cells. The above results suggest that immunomagnetic bead depletion of the harvested marrow will likely be superior to our previous method of purging and the lack of nonspecific toxicity to myeloid progenitor cells predicts that it will not impair engraftment. This methodology will now be used to determine whether the reinfusion of lymphoma free marrow affects the incidence of relapse after autologous bone marrow transplantation.
U.S. Geological Survey Assessment Methodology for Estimation of Undiscovered Petroleum Resources in Play Analysis of the Arctic National Wildlife Refuge

The objective of this investigation was to develop a geostochastic system for estimation of undiscovered petroleum resources in play analysis. A resource appraisal system was designed for play analysis using a reservoir-engineering model and an analytic probabilistic methodology. The system resulted in a package of computer programs, called FASP, for play analysis, subplay analysis, mixed-lithology analysis, and aggregations. Resource estimates of crude oil, nonassociated gas, dissolved gas, and total gas are calculated in terms of probability distributions as tables and graphs. The FASP computer package is a large complex system that is very flexible and efficient, but which can easily be adapted to most microcomputers. This system was used by the U.S. Geological Survey to assess the in-place petroleum potential of the Arctic National Wildlife Refuge located in northeastern Alaska.
Graded Logic Aggregation

This paper summarizes basic properties of graded logic – a natural soft computing generalization of classical Boolean logic. Using graded logic aggregators we can build evaluation criteria and apply them in decision engineering. This paper is an extended summary that surveys key concepts of graded logic and graded logic aggregation.
Seasonal Changes in Nestmate Discrimination in the Paper Wasp, Polistes metricus Say (Hymenoptera: Vespidae)

Nestmate discrimination in the paper wasp, Polistes metricus Say (Hymenoptera: Vespidae) was examined during each stage (nesting and non-nesting phases) of the colony cycle. Resident wasps of each caste were paired with nestmates or non-nestmates of the same caste in a clear plastic box near the nest in the field and all aggressive and non-aggressive behavioral interactions initiated by the resident wasps were noted. Each wasp caste, particularly the resident foundress, workers, and males exhibited a significantly high proportion of aggressive behaviors towards non-nestmates than towards nestmates, thus demonstrating nestmate discrimination. However, the response of resident fall gynes towards nestmates and non-nestmates was not significantly different. During winter, gynes of P. metricus and P. fuscatus Fabricius were found to overwinter together in the same clusters. The overwintering gynes of P. metricus showed complete tolerance towards conspecifics (non-nestmates) and allospecifics (P. fuscatus). These findings suggest that the acceptance threshold of P. metricus shifts from being restrictive towards the beginning of the nesting phase to being permissive towards the end, which differs from previous studies on P. fuscatus, whose acceptance threshold was more restrictive during the reproductive phase than during the worker phase. However, during the non-nesting (overwintering) phase of the colony cycle, the acceptance threshold likely becomes even more permissive to an “accept-all” level in both species. These shifts in acceptance threshold follow the predictions of Reeve's (1989) conspecific acceptance threshold model, and most likely reflect the cost-benefit ratio assessment of wasps to minimize negative inclusive fitness consequences at each stage of the colony cycle.
$In~Situ$ and In-Field Technique for Monitoring and Decelerating NBTI in 6T-SRAM Register Files

This paper presents a technique to monitor and decelerate transistor threshold voltage ( $V_{\text {TH}}$ ) degradation caused by negative bias temperature instability (NBTI) in SRAM-based register files (RFs). The monitoring technique is in situ as it can directly sense the $V_{\text {TH}}$ of pMOSs in a bitcell. It is also in-field (i.e., postchip deployment) since the sensor output is robust to temperature and supply-voltage variations. The monitoring technique is complemented with a software framework that can create recovery vectors ( $\text {RV}_{\text {SRV}}$ ) based on the measured $V_{\text {TH}}$ degradation, which we can decelerate NBTI degradation by storing them opportunistically in an RF when the system is at stand-by mode. Test chips for a 1-kb RF with the proposed technique are prototyped in a 65-nm process. The average errors to monitor a considerable amount of NBTI degradation (>30-mV $V_{\text {TH}}$ degrading) against temperature (20 °C–80 °C) and supply-voltage (0.5–1 V) variations are 19% and 22%, respectively. These errors are $4.4\times $ and $3.4\times $ smaller than the previous in situ techniques. In addition, the experiments across multiple chips show that the generated $\text {RV}_{\text {SRV}}$ can recover a good portion of NBTI degradation and thus decelerate the degradation of data retention voltage. The area overhead of the proposed technique is 27% for the 1-kb RF and estimated to be 21% for a 4-kb RF.
Patricia Marín Cepeda (ed.), En la concha de Venus amarrado. Erotismo y literatura en el Siglo de Oro. Visor Libros, Madrid, 2017; 271 pp. (Biblioteca Filológica Hispánica, 188).

Este volumen, de sugestivo titulo, reune once ensayos que abordan el motivo del erotismo literario en diversas facetas, dando cabida a reveladoras investigaciones sobre este tema que, como afirma la editora, no solo no esta agotado, sino que abre nuevos caminos para la critica.
Celebrating life or adversity? The redefinition of features in the Pictures of the Year International contest:

Photojournalism contests have been criticized for continually awarding top prizes in hard news categories to images that depict conflict, disaster, poverty, and other problems. Pictures like these,...
Intimacies: An Integrative Multicultural Framework for Couple Therapy

Implicitly or explicitly, our ideas about intimacy are the most fundamental notions giving direction to the process of couple therapy. Yet, as a field, we have spent little time conceptualizing intimacy and even less time considering the diversity of priorities and meanings couples bring to our offices. In Part One, Varieties of Intimacy, I describe a kaleidoscope of contexts-socio-historical, cultural, gender, life cycle, and developmental-that inform our ideas and expectations for intimacy in couples' relationships. I highlight different spheres in which intimacy may take place such as the emotional, sexual, intellectual, or familial. I propose a starting point in which the therapist, in a collaborative manner, helps the partners articulate their yearnings and priorities in order to negotiate a shared vision. In Part Two, Conceptualizing Intimacy, I suggest an experiential definition that gives room for each partner's subjective meanings, yet consider diverse relational processes that may need to be addressed for a resilient ebb and flow of intimate experiences. In Part Three, Sexual Intimacy, I outline conditions in which sex is more likely to be experienced as intimate rather than nonintimate. Finally, in Part Four, I describe Therapeutic Principles to guide the therapist in taking couples from reactivity to dialogue to negotiations of intimacy. The integrative framework proposed here discourages monolithic a priori notions of intimacy and highlights instead: nuanced meanings, relational processes to be considered differentially, present and past emotional blocks, and a flexible clinical approach to foster conditions for the creation and resilience of intimate experiences.
Genetically variable olfactory receptor sensitivity in Periplaneta America

Abstract From continuing research on the physicochemical aspects of 1, 4-naphthoquinone perception by adult Periplaneta americana , genetically distinct strains with markedly different behavior sensitivities to the quinones have been found. A nerve-membrane bound macromolecular component involved in this napthoquinone perception has been identified. Correlates between different in vitro interactions of various quinone messengers with the isolated proteinaceous macromolecule, and between different in vivo effects of the quinones upon the two studied strains of P. americana are reported.
Statistics and health care fraud: how to save billions: by Tahir Ekin, CRC Press, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742, 2019, 141+xviii pp., $23.96 (paperback), ISBN: 978-1-138-10639-0

Refinement of health care requires the elimination of frauds. This book is all about how statistical and analytical methods could help to reduce health care frauds if not their total elimination. N...
Implementing pediatric inpatient asthma pathways.

Objective: Pathways are succinct, operational versions of evidence-based guidelines. Studies have demonstrated pathways improve quality of care for children hospitalized with asthma, but we have li...
There and Back Again. . . Safely: Examining Students' Reports of Substance Use and Sexual Assault Prevention Program Receipt Prior to Departure Abroad.

Many universities have pre departure programs that aim to prevent alcohol misuse and sexual assault among college students abroad, yet little is known about students’ uptake of this preventative information. In this study, 2,245 study abroad students from 63 different institutions were asked about receiving pre departure alcohol/drug and sexual assa ult prevention information. Only 38% of students reported receiving pre departure information specific to alcohol/drug misuse abroad and only 22% reported receiving sexual assault prevention information prior to departure. Notably, students who were heavie r drinkers prior to departure and those who intended to drink the most while abroad reported lower rates of information receipt. Overall, these findings suggest that either students are not receiving the preventative information that universities intend them to receive or the programming is not impactful enough to be recalled. Thus, there may be missed opportunities to better prepare students for risks specific to study abroad programs.
System Identification of High-Dimensional Linear Dynamical Systems With Serially Correlated Output Noise Components

We consider identification of linear dynamical systems comprising of high-dimensional signals, where the output noise components exhibit strong serial, and cross-sectional correlations. Although such settings occur in many modern applications, such dependency structure has not been fully incorporated in existing approaches in the literature. In this paper, we explicitly incorporate the dependency structure present in the output noise through lagged values of the observed multivariate signals. We formulate a constrained optimization problem to identify the space spanned by the latent states, and the transition matrices of the lagged values simultaneously , wherein the constraints reflect the low rank nature of the state information, and the sparsity of the transition matrices. We establish theoretical properties of the estimators, and introduce an easy-to-implement computational procedure for empirical applications. The performance of the proposed approach, and the implementation procedure is evaluated on synthetic data, and compared with competing approaches, and further illustrated on a data set involving weekly stock returns of 75 US large financial institutions for the 2001–2017 period.
Unimodular Methylation by Adenylation–Thiolation Domains Containing an Embedded Methyltransferase

Nonribosomal peptides (NRPs) are natural products that are biosynthesized by large multi-enzyme assembly lines called nonribosomal peptide synthetases (NRPSs). We have previously discovered that backbone or side chain methylation of NRP residues is carried out by an interrupted adenylation (A) domain that contains an internal methyltransferase (M) domain, while maintaining a monolithic AMA fold of the bifunctional enzyme. A key question that has remained unanswered is at which step of the assembly line mechanism the methylation by these embedded M domains takes place. Does the M domain methylate an amino acid residue tethered to a thiolation (T) domain on same NRPS module (in cis), or does it methylate this residue on a nascent peptide tethered to a T domain on another module (in trans)? In this study, we investigated the kinetics of methylation by wild-type AMAT tridomains from two NRPSs involved in biosynthesis of anticancer depsipeptides thiocoraline and echinomycin, and by mutants of these domains, for which methylation can occur only in trans. The analysis of the methylation kinetics unequivocally demonstrated that the wild-type AMATs methylate overwhelmingly in cis, strongly suggesting that this is also the case in the context of the entire NRPS assembly line process. The mechanistic insight gained in this study will facilitate rational genetic engineering of NRPS to generate unnaturally methylated NRPs.
Transition-Metal Nitroprussides Examined for Water Harvesting and Sorption Cooling.

Transition-metal pentacyanonitrosylferrates, commonly known as nitroprussides, have a long and documented history. Here, we synthesize cobalt and nickel nitroprussides (NPs) in order to probe their...
The use of a primary care provider survey to implement a fall prevention program in an urban hospital system.

Abstract Background Falls are the leading cause of traumatic injury in older adults. Multidisciplinary approaches between trauma surgeons and primary care providers can powerfully advocate for fall prevention. This study explores current fall prevention practices and barriers to falls screening and prevention in the primary care setting and proposes pertinent recommendations to address the deficiencies. Methods A questionnaire was adapted from a previous survey study to explore the beliefs, knowledge, attitudes, and clinical practice regarding falls by primary care providers. The questionnaire was distributed by e-mail to primary care providers at a tertiary urban medical center. Results The survey achieved a response rate of 58%. All respondents agreed that older adult patients should be assessed for fall risks and that evidence-based fall prevention programs can reduce the risk of falls. However, 43% of respondents did not agree that they had the expertise to perform fall risk assessments, and similarly 43% did not agree they have the time to perform fall risk assessments in the office. Furthermore, although 52% of respondents were aware of the Medicare reimbursement for fall risk screening, only 24% had billed for fall risk screening and only 5% agreed that they were adequately reimbursed. Conclusion Several barriers to performing fall prevention care in the primary care setting were identified: unfamiliarity with resources, perceived lack of time, and perceived insufficient reimbursement. We implemented a set of interventions which include an educational series and workflow optimization to overcome barriers identified.
Pricing equity default swaps under the jump-to-default extended CEV model

Equity default swaps (EDS) are hybrid credit-equity products that provide a bridge from credit default swaps (CDS) to equity derivatives with barriers. This paper develops an analytical solution to the EDS pricing problem under the jump-to-default extended constant elasticity of variance model (JDCEV) of Carr and Linetsky. Mathematically, we obtain an analytical solution to the first passage time problem for the JDCEV diffusion process with killing. In particular, we obtain analytical results for the present values of the protection payoff at the triggering event, periodic premium payments up to the triggering event, and the interest accrued from the previous periodic premium payment up to the triggering event, and we determine arbitrage-free equity default swap rates and compare them with CDS rates. Generally, the EDS rate is strictly greater than the corresponding CDS rate. However, when the triggering barrier is set to be a low percentage of the initial stock price and the volatility of the underlying firm’s stock price is moderate, the EDS and CDS rates are quite close. Given the current movement to list CDS contracts on organized derivatives exchanges to alleviate the problems with the counterparty risk and the opacity of over-the-counter CDS trading, we argue that EDS contracts with low triggering barriers may prove to be an interesting alternative to CDS contracts, offering some advantages due to the unambiguity, and transparency of the triggering event based on the observable stock price.
Adaptive Gain Tuning of Onboard Chargers to Mitigate Parameter Uncertainty in V2G Interfaces

A technical challenge of interfacing electric vehicles (EVs) to the grid is in the design of the LC or LCL filter. The filter must have the capability to meet both the EV automotive requirements and the distribution grid requirements such as current ripple and steady state error. Furthermore, the filter design must accommodate bidirectional energy flow and should be re-configurable for various grid types such as single-phase, three-phase, and three-phase four-wire grid systems. All these stringent requirements along with the fact that the input filter of the EV occupies 30% of the (onboard charger) OBC size, lead to a very difficult bottleneck to minimize the power density and cost. This paper proposes an adaptive gain tuning to allow using a powdered-core inductor that has a smaller size than its ferrite core counterpart. The main difference of the powdered core is that its inductance reduces linearly with the current passing through it, while ferrite cores inductance remains constant until it reaches the knee point where the inductance decreases sharply. The proposed adaptive gain tuning shows that the controller requirements can be met with the inductance value uncertainty and linearly changing core inductance.
Realization of Maximum 2 A/mm Drain Current on Top-Gate Atomic-Layer-Thin Indium Oxide Transistors by Thermal Engineering

In this work, we demonstrate the record high maximum drain current ( $I_{D}$ ) of 2 A/mm of top-gate (TG) indium oxide (In₂O₃) transistors. The scaled and atomic-layer-deposited (ALD) In₂O₃ transistors have channel length ( $L_{ch}$ ) down to 40 nm and channel thickness ( $T_{ch}$ ) down to 1.3 nm. Besides, the thermal budget of the whole material formation and device fabrication process is as low as 225 °C, making it compatible with back-end-of-line (BEOL) technologies by a huge margin. On the other hand, highly resistive silicon is utilized to serve as a desired high thermal conducting substrate to dissipate the generated heat efficiently as a larger current is conducted under a larger voltage bias. It greatly alleviates the self-heating effect (SHE) and allows an approximately 100% higher drain current. Quantitative studies of the SHE and channel temperature at on-state with SiO₂/Si and highly resistive silicon substrates are also presented.
Getting started with the Internet

Introduction to the Internet Electronic Mail (E-Mail) Internet News Telnetting Internet Tools File Transfers (FTP) Using Mosaic Bibliography Glossary Index.
Survey of dermoscopy use by Taiwanese dermatologists

Abstract Background Dermoscopy is a useful technique for improving the diagnostic accuracy of various types of skin disorders. Although the technique has been widely adopted by European, Australian, and United States dermatologists, only limited information is available on the prevalence of dermoscopy use in Taiwan. Objectives We assessed the use and barriers to adoption of dermoscopy among Taiwanese dermatologists to determine the relationship between dermoscopy use and the characteristics of dermoscopy users. Methods A questionnaire of 20 items regarding demographic characteristics, dermoscopy training, and application was mailed to all dermatologists listed in the 2013 Taiwanese Dermatological Association registry. Results: Of the 950 mailed questionnaires, 202 were returned and 195 were identified to be eligible. Of the valid respondents, 51.8% used dermoscopy and 62.1% had attended courses for dermoscopy training. Dermoscopy use was significantly associated with women ( p = 0.018), residents ( p p p p p p Conclusion This is the first published survey about the application of dermoscopy in Taiwan. Despite a low response rate and potential selection bias, our study revealed that dermoscopy is increasingly being accepted by Taiwanese dermatologists in daily practice. In addition, the study offered an opportunity to introduce all dermatologists to this technique.
Examining Learning Experience in Two Online Courses Using Web Logs and Experience Sampling Method (ESM)

Web mining and visualization techniques are used to discover the underlying patterns of online learning experience. Yet, the analytics are often limited to merely behavioral data lacking other critical dimensions that form an important part of the learning experience such as learners’ cognitive involvement and emotional experience. Therefore, it is critical to find a method that can capture a holistic online learning experience while a learner progresses in an online course. This chapter introduces the Experience Sampling Method (ESM) that can be used to supplement Web Log Analysis (WLA) by collecting data on learners’ cognitive involvement and emotion in each learning task. Then this chapter reports a case study of utilizing the ESM and WLA to examine online learning experiences in a discussion-focused online course and a design-/development-focused online course. Lastly, a visualized learning experience dashboard is presented to show an individual learner's learning experience based upon the three dimensions of learning experience.
A model-free predictor framework for tele-operated vehicles

One important challenge with vehicle teleoperation is that the communication delays can negatively affect the driving performance. To address this challenge, this paper adopts a model-free predictor based framework that, unlike previously reported efforts, does not require the predictor to know and model the system dynamics. This is achieved by communicating only the state variables and their derivatives that appear in the output equation for the calculation of the coupling variables. The difference between the predictor's states and the system states results in an error system that is described by a delay differential equation and its stability is established for constant delays. First, this idea is adopted into a generic vehicle tele-operation framework. Then, it is applied to a simulated vehicle-driver system to evaluate the performance of the approach over various constant delays, stochastic delays, and a real network connection. The conclusion is that the approach holds a significant potential to alleviate the negative impact of delay and improve the performance of tele-operated vehicles.
Developing a learning community approach to business ethics education

In this paper we discuss a project, still in progress, that moves away from a traditional lecture based educational pedagogy. We present a team taught approach to ethics teaching that embraces a progressive philosophy of education and is focused on the development of a discussion based learning community. We describe our primary pedagogical tools of case discussion and the development of student expert role assignments as a locus, and how they relate to the learning community, course content and course objectives. Finally, we provide our preliminary review of outcomes and emerging issues.
A Bayesian technique for task localization in multiple goal Markov decision processes

In a reinforcement learning task library system for Multiple Goal Markov Decision Process (MGMDP), localization in the task space allows the agent to determine whether a given task is already in its library in order to exploit previously learned experience. Task localization in MGMDPs can be accomplished through a Bayesian approach, however a trivial approach fails when the rewards are not distributed normally. This can be overcome through our Bayesian Task Localization Technique (BTLT).