cssi/SciSciGPT-SciSciNet huggingface dataset:
The effect of extracorporeal shock wave lithotripsy on the prosthesis interface in cementless arthroplasty. Evaluation in a rabbit model.

The effect of extracorporeal shock wave lithotripsy on interfacial strength between prosthesis and bone in cementless arthroplasty was examined using a rabbit model. Paired femora, each implanted with fiber mesh porous coated titanium implants, were harvested from rabbits 15 weeks after implantation. In group I, one femur from each pair was exposed to lithotripsy treatment consisting of 2,000 shocks at 20 kV. In group II, one femur from each pair was exposed to 2,000 shocks at 26 kV. Contralateral femora from each pair served as controls in both groups. Mechanical pushout tests were conducted on the implants using a 1321 Instron testing machine at a constant rate of 1 mm/minute. Shock waves generated at 20 kV were found to have no significant decrease on either the prosthesis/bone interfacial strength or energy to failure of cementless implants. Shock waves generated at 26 kV produced a mean 17.45% decrease in the prosthesis/bone interfacial strength, which approached statistical significance (P = .062), and a 7.84% mean decrease in the energy to failure (P = .268). However, in four of the seven group II specimens, cortical fractures occurred. These findings suggest that lithotripsy will not aid in the removal of uncemented porous coated devices and lithotripsy inadvertently focused at an uncemented device will not disrupt significantly the prosthesis-bone interface.
Legitimizing colonial privilege: Native Americans at a quincentenary of discourse

ETHNOCRITICISM: ETHNOGRAPHY, HISTORY, LITERATURE. By Arnold Krupat. Los Angeles: University of California Press, 1992; pp. 3–273; paper $12.95. FANTASIES OF THE MASTER RACE: LITERATURE, CINEMA AND THE COLONIZATION OF AMERICAN INDIANS. By Ward Churchill, edited by M. Annette Jaimes. Monroe, ME: Common Courage Press, 1992; pp. 1–304; paper $14.95. THE STATE OF NATIVE AMERICA: GENOCIDE, COLONIZATION, AND RESISTANCE. Edited by M. Annette Jaimes. Boston: South End Press, 1992; pp. vii‐460; $40.00; paper $18.00.
Electrolyte and Gas Exchange during the Moulting Cycle of a Freshwater Crayfish

Whole-animal net electrolyte fluxes (Ca2+, apparent H+, titratable acidic equivalents, ammonia, Na+, Cl−, K+, Mg2+, phosphate and sulphate) and respiratory gas exchange were monitored throughout the moulting cycle in juvenile freshwater crayfish Procambarus clarkii (Girard) at 21 °C. Intermoult crayfish were essentially in ion balance. As crayfish approached ecdysis (−3 days, where t=0 is the day when the cuticle is shed), there was a net efflux of Ca2+ (−1000μmolkg−1 h−1) correlated with a corresponding uptake of acidic equivalents (or base output) of +2000μmolkg−1 h−1. Following ecdysis, both fluxes switched vector; uptake of Ca2- (+2000μmolkg− h−) and basic equivalents (+4000μmolkg−1h−1) were completed within 6 days. The moulting cycle also affected fluxes of electrolytes other than those involved in CaCO3 resorption and deposition. Crayfish remained in Na+; and C−; balance from intermoult up to ecdysis. Following ecdysis, both were taken up actively at rates of around plus;500μanolkg−1h−1 for 3 days, presumably restoring the haemodilution that would have resulted from water loading. A premoult efflux of K+ was partially offset by postmoult uptake. Meanwhile, crayfish experienced increased efflux of phosphate following ecdysis, probably because of increased integumentary permeability. Rates of O2 uptake (MO2) and CO2 excretion (Mco2) increased to peak values (double intermoult rates) immediately prior to ecdysis. While MO2 recovered during postmoult, Mco2 dropped precipitously, significantly reducing the gas exchange ratio. Since the Mco2 deficit agreed well with the postmoult basic equivalent uptake, the latter is probably attributable to HCO3− uptake for calcification.
Olanzapine Reduces Craving for Alcohol: A DRD4 VNTR Polymorphism by Pharmacotherapy Interaction

Separate investigations have suggested that olanzapine, a D4 antagonist, decreases craving after a priming dose of alcohol and that the DRD4 variable number of tandem repeats (VNTR) polymorphism influences the expression of craving after a priming dose of alcohol. The present study tested the hypothesis that olanzapine may be differentially effective at reducing cue-elicited craving based on individual differences in DRD4 VNTR in a sample of heavy social drinkers. Participants were randomly assigned to receive olanzapine (5 mg) or a control medication (cyproheptadine, 4 mg) prior to consuming three alcoholic drinks. Participants completed subjective measures of craving and euphoria after each drink. Participants who were homozygous or heterozygous for the 7 (or longer) repeat allele of the DRD4 VNTR were classified as DRD4 L, while the other participants were classified as DRD4 S. The findings indicated that olanzapine reduces craving for alcohol at baseline for both DRD4 S and DRD4 L individuals, but only reduces craving after exposure to alcohol cues and after a priming dose of alcohol for DRD4 L individuals.
A synthetic approach to the design of information-systems software

This paper presents an approach to the design of information-systems software in which alternative designs can be created, as necessary, until specified requirements are met and specific objectives achieved. Thii approach takes advantage of, and in fact complements. the abstraction process that characterizes the abstraction-synthesis methodology of information-systems development. A broad concept of function support, as provided by the information system, and a design-independent specification of information-systems requirements, are basic features of this methodology. The view of design presented here takes advantage of these features by providing the necessary flexibility. Design itself is viewed as a search on the space of possible software-system structures until one which satisfies the requirements of the information system and achieves the project’s objectives is found. The design space is defined on four dimensions that correspond to important layers of information-system software implementation.
A Cautionary Tale About the Use of Administrative Data: Evidence from Age of Marriage Laws †

This paper demonstrates that administrative data may be inferior to survey data under particular circumstances. We examine the effect of state laws governing the minimum age of marriage in the United States. The estimated effects of these laws are much smaller when based on retrospective reports from census versus administrative records from Vital Statistics data. This discrepancy appears due to systematic avoidance behavior of two kinds. Some young people marry in states with less restrictive laws; others appear to have mis represented their age on their marriage certificate. Our results have important implications regarding legal avoidance and the use of administrative data. (JEL J12 K36) This paper presents a cautionary note about the use of administrative data in empirical work, especially work devoted to assessing the behavioral effects of laws. The behavioral changes induced by laws often represent important tests of the ory and, because they are plausibly exogenous, may be exploited to identify various causal effects. Increasingly, scholars studying the effects of laws, and other empiri cal questions, rely on administrative data. These data are drawn from official records and are thus thought to provide more reliable information about the behaviors they record than do general surveys. We argue that this presumption may often be incor rect, with important implications for the validity of empirical analysis. When a particular behavior has been outlawed, there will be people who modify their behavior as intended by the law and others who attempt to circumvent the law in various ways. In particular, "noncompliers" can either (a) move to an area where the behavior is not outlawed and engage in it there or (b) break the law where they are.1 Both these actions bias administrative records toward suggesting larger
The effect of morphologic subtype on outcomes following the Sano-Norwood procedure

OBJECTIVES: Controversy exists concerning outcomes of patients with different morphologic subtypes of hypoplastic left heart syndrome undergoing the Norwood procedure, in particular, aortic atresia-mitral stenosis (AA-MS) patients receiving a systemic–pulmonary modified Blalock-Taussig (mBT) shunt. We sought to determine the influence of known risk factors and morphology on early survival in our cohort of Sano–Norwood patients with right ventricle–pulmonary artery (RV–PA) conduits as the source of pulmonary blood flow. METHODS: We studied early survival in patients with Sano-modified Norwood procedures from 2002 to 2010 and included both typical and atypical (including unbalanced atrioventricular canal defect) morphologic variants. We included a comparison group composed of classical Norwood patients with mBT shunts. RESULTS: Of 264 Sano–Norwood patients, 49 had AA-MS and 30 had atypical morphologies. Weight ≤2.5 kg was associated with a poorer 1-year survival (P = 0.0007), though ascending aorta (AscAo) size <2.0 mm was not. We did not observe a difference in 30-day or 1-year Kaplan–Meier (K–M) survival across typical morphologic variants for either a Sano or mBTS group. Atypical variants exhibited a trend towards lower 30-day and 1-year survival in both Sano and mBTS groups though this was not significant. Direct comparison of 30-day K–M survival for Sano versus mBTS in AA-MS patients showed similar outcomes (P = NS). CONCLUSIONS: Use of the RV–PA conduit results in good early survival, even in those with a small AscAo size. Atypical morphologic variants seem to do worse irrespective of the Sano or mBTS group. Further studies will be required to determine conclusively whether the RV–PA shunt confers protective effects in the AA-MS subgroup compared with the mBTS.
Providing Patient-Focused Care Within a Managed Care and Pharmaceutical Care Environment: A Person/Situation Interactionist Model for Community Practitioners

OBJECTIVE: To propose an interactionist model of community pharmacists' patient-focused care to help researchers examine patient care activities under the twin paradigm changes of managed care and pharmaceutical care. SETTING: Community pharmacies. DESCRIPTION: The model suggests that more accurate predictions concerning community practitioners' patient care activities can be made by simultaneously examining both individual variables (e.g., self-efficacy) and situational variables (e.g., organizational reward system) than by examining either one separately. A major component of the model uses Kohlberg's cognitive moral development theory, which has been significantly and pragmatically linked to health professionals' clinical performance. Research propositions are offered and directions of future research discussed.
An in Situ Small Angle Neutron Scattering Investigation of AgO.7Au0.3 Dealloying

In situ small angle neutron scattering (SANS) was used to characterize the formation of the random 3-dimensional porous structure created during the free corrosion of a Ag0.7Au0.3 alloy in concentrated HNO3. The evolution of the porosity was followed in situ for a period of 21 hours. The average ligament width evolved from a size of approximately 6 nm following only 7 minutes of dealloying to approximately 22.5 nm after 21 hours of de-alloying. Using a model developed by N.F. Berk (Phys. Rev. Lett., 58 (1987) 2718) for the scattering properties of random porous media, we were able to characterize the average ligament width distribution as a function of time. Our results represent the first in situ nanoscale characterization of the formation of 3-dimensional porosity in a corrosion system.
Radiolysis of Water on ZrO2 Nanoparticles

The radiolysis of water adsorbed on the surface of ZrO2 nanoparticles has been examined using a variety of spectroscopic techniques. Irradiations were performed with fast electrons, γ rays, and 5 MeV helium ions. Infrared spectroscopic analysis of the surface reveals little change in the surface stoichiometry, which probably indicates the relative insensitivity of this technique to the doses given. X-ray photoelectron spectroscopy reveals a loss in the relative number of terminal OH groups on the surface with radiolysis. The maximum production of excess H2 is found when a single water layer or less is adsorbed on the terminal OH surface layer. Little or no H2 seems to come from the surface-bound OH groups.
Characterization of mesenchymal stromal cells: potency assay development

Based on their many different mechanisms of action, presumed immune-privileged status, and relative ease of production, mesenchymal stromal cells (MSCs) are under intensive clinical investigation for treating a wide range of degenerative, inflammatory, and immunologic disorders. Identification of relevant and robust potency assays is not only a regulatory requirement, but it is also the basis for producing and delivering a product that is consistent, safe, and ultimately an effective therapy. Although development of an appropriate potency assay is one of the most challenging issues in cell-based therapies, it is of paramount importance in the process of developing and testing cellular products. Regardless of the many different tissue sources and methods used in culture expansion of MSCs, they possess many of the same morphologic, cell surface markers, and differentiation characteristics. However, MSC products with similar phenotypic characteristics could still have major differences in their biologic and functional attributes. Understanding the different mechanisms of action and establishment of relevant potency assays is of pivotal importance in allowing investigators and regulatory agencies to compare MSCs used in different clinical trials.
Surgical and medical management of local-regional treatment failures in advanced primary breast cancer.

Close cooperation between medical and surgical oncologists and the reconstructive surgeon is required to assess the advisability of major resections of either persistent advanced primary disease or local-regional recurrences and the associated short- and long-term morbidity of the surgical procedure itself. In general, quality palliation can often control local symptoms of pain, hemorrhage, and malodorous ulceration. Surgical procedures in combination with irradiation to debulk an infected tumor mass may also allow selected patients to receive chemotherapy. If life expectancy is anticipated to be very short, as with patients who have bulky visceral disease or metastases nonrespondant to multiple chemotherapy regimens, the true benefit of a complex but technically feasible operation should be evaluated carefully.
Geometrical Interpretation of the Shape Parameters

The two inherent shape parameters of the Beta-spline, β1 and β2, provide further control of shape in addition to, and independent of, that supplied by the positional information specified by the control vertices. These shape parameters have the property that β1 = 1 indicates continuity of the parametric first derivative vector and β1 = 1 with β2 = 0 indicates continuity of the parametric first and second derivative vectors.
Veracity, verity, and verum in liturgy

Les verites du monde physique se decouvrent alors que celles du monde symbolique se fabriquent. L'epistemologie de la decouverte menace l'ontologie de la construction symbolique. Par consequent, la liturgie dans laquelle repose la verite de ce monde symbolique, est une forme singuliere de rituel qui est le point central sur lequel doivent travailler les theologiens et les liturgistes afin d'eviter que le rationalisme triomphant ne rende la condition humaine insupportable
Using performance maps to build a real time decision making framework

This paper presents a real time decision making framework used to create a decision process based on multiple performance maps composed of volatile functional values to assist in complex decisions for highly nonlinear systems by allowing human visualization and direct algebraic computations. The framework, based on map-based process is intended to extend other decision tools used in the synthesis process, such as neural networks, fuzzy logic and classical control and optimization by archiving knowledge learned and data uncertainty in geometric representation during the process execution. Time is critical to provide reliable and exact response as the systems become more complex. This real time decision making framework maintains the structure of previous research projects performed by the Robotics Research Group where the selected maps are combined into envelopes as functional decision surfaces, but including the real-time constraints in the decision process. The potential and applicability of this technology is used in different knowledge domains, ranging from ground vehicles navigation, unmanned aerial vehicles, health care management systems, and intelligent actuators.
No compelling evidence for a bilingual advantage in switching or that frequent language switching reduces switch cost

ABSTRACTParticipants completed three cued-switching tasks, responded to two category-fluency probes, two letter-fluency probes, and two probes to alternate between two targets. Correlations across the three cued-switching tasks were significant for both switching costs and mixing costs. The bilingual advantage hypothesis was tested both by forming language groups and treating bilingualism as a continuous variable. No bilingual advantages were observed. In verbal-fluency monolinguals generated more correct responses but the bilingual disadvantage on the category task was not reduced in the letter-fluency scores. The bilingual disadvantage was eliminated when the groups were matched on vocabulary size. The verbal-fluency measures obtained when participants alternated between targets weakly correlated with the switching-costs obtained in the cued-switching tasks.
The path towards sustainable energy

Civilization continues to be transformed by our ability to harness energy beyond human and animal power. A series of industrial and agricultural revolutions have allowed an increasing fraction of the world population to heat and light their homes, fertilize and irrigate their crops, connect to one another and travel around the world. All of this progress is fuelled by our ability to find, extract and use energy with ever increasing dexterity. Research in materials science is contributing to progress towards a sustainable future based on clean energy generation, transmission and distribution, the storage of electrical and chemical energy, energy efficiency, and better energy management systems.
The Evolution of the Fellows-in-Training and Early Career Professionals' Page: Past, Present, and Future.

Since he began his tenure as editor-in-chief of the Journal in July 2014, Dr. Valentin Fuster has been deeply committed to the personal and professional development of both trainees and early career professionals. Thus, the Fellows-in-Training (FIT) & Early Career (EC) Page was born. It soon
Clinical feasibility of 90Y digital PET/CT for imaging microsphere biodistribution following radioembolization.

Purpose The purpose of this study was to evaluate the clinical feasibility of next generation solid-state digital photon counting PET/CT (dPET/CT) technology and imaging findings in patients following 90Y microsphere radioembolization in comparison with standard of care (SOC) bremsstrahlung SPECT/CT (bSPECT/CT).
Lack of a head in human spermatozoa from sterile patients: A syndrome associated with impaired fertilization

Three patients with primary sterility in whom the majority of spermatozoa lacked a normally implanted head are presented. A small cephalic knob was evident in most of them by routine colorimetric techniques, and the Feulgen reaction failed to show any deoxyribose nucleic acid. The morphologic features of the tails was normal. Few loose sperm heads were observed in the ejaculates. Even though motility was decreased, there were numerous acephalic sperms with different degrees of forward motility. Electron microscopy showed a well-organized structure of the centrioles and connecting piece, which were located in the neck region within a small cytoplasmic mass, but no chromatin was detected in any case. Studies on immature spermatids present in semen evidenced an independent anomalous development of heads and tails and suggested that they became separated at the end of spermatid maturation. This anomaly, of probable genetic origin, is interpreted to be due either to an alteration in the mechanism of migration and positioning of the tail on the caudal pole of the nucleus or to an interference with the formation of the implantation fossa of the head, which normally accommodates the connecting piece.
Political philosophy and political action: imperatives of resistance

This book is a multidimensional examination of the concept of ‘resistance,’ defined by the author as: ‘group opposition, either formal or informal, against some element of the status quo that is do...
Evidence of small-fiber neuropathy (SFN) in two patients with unexplained genital sensory loss and sensory urinary cystopathy.

• SFN can occur in a non length-dependent pattern, evidenced here by the reduced ENFD in the thigh compared to the distal leg.
Acute chest pain evaluation using coronary computed tomography angiography compared with standard of care: a meta-analysis of randomised clinical trials

Objective Coronary CT angiography (CCTA) has certain advantages compared with stress testing including greater accuracy in identifying obstructive coronary disease. The aim of the study was to perform a systematical review and meta-analysis comparing CCTA with other standard-of-care (SOC) approaches in evaluation of patients with acute chest pain. Methods Electronic databases were systematically searched to identify randomised clinical trials of patients with acute chest pain comparing CCTA with SOC approaches. We examined the following end points: mortality, major adverse cardiac events (MACE), myocardial infarction (MI), invasive coronary angiography (ICA) and revascularisation. Pooled risk ratios (RR) and their 95% CIs were calculated using random-effects models. Results Ten trials with 6285 patients were included. The trials used different definitions and implementation for SOC but all used physiologic testing. The clinical follow-up ranged from 1 to 19 months. There were no significant differences in all-cause mortality (RR 0.48, 95% CI 0.17 to 1.36, p=0.17), MI (RR 0.82, 95% CI 0.49 to 1.39, p=0.47) or MACE (RR 0.98, 95% CI 0.67 to 1.43, p=0.92) between the groups. However, significantly higher rates of ICA (RR 1.32, 95% CI 1.07 to 1.63, p=0.01) and revascularisation (RR 1.77, 95% CI 1.35 to 2.31, p Conclusions Compared with other SOC approaches use of CCTA is associated with similar major adverse cardiac events but higher rates of revascularisation in patients with acute chest pain.
Keeping Multiple Views Consistent: Constraints, Validations, and Exceptions in Visualization Authoring

Visualizations often appear in multiples, either in a single display (e.g., small multiples, dashboard) or across time or space (e.g., slideshow, set of dashboards). However, existing visualization design guidelines typically focus on single rather than multiple views. Solely following these guidelines can lead to effective yet inconsistent views (e.g., the same field has different axes domains across charts), making interpretation slow and error-prone. Moreover, little is known how consistency balances with other design considerations, making it difficult to incorporate consistency mechanisms in visualization authoring software. We present a wizard-of-oz study in which we observed how Tableau users achieve and sacrifice consistency in an exploration-to-presentation visualization design scenario. We extend (from our prior work) a set of encoding-specific constraints defining consistency across multiple views. Using the constraints as a checklist in our study, we observed cases where participants spontaneously maintained consistent encodings and warned cases where consistency was overlooked. In response to the warnings, participants either revised views for consistency or stated why they thought consistency should be overwritten. We categorize participants' actions and responses as constraint validations and exceptions, depicting the relative importance of consistency and other design considerations under various circumstances (e.g., data cardinality, available encoding resources, chart layout). We discuss automatic consistency checking as a constraint-satisfaction problem and provide design implications for communicating inconsistencies to users.
The Early Thought of Royce

The Religious Aspect of Philosophy was the first major work of Josiah Royce and it established his reputation as a philosopher. This first work has in common with his last major works that they were studies in philosophy of religion. Although they differ significantly, each proceeds by presenting a moral philosophy followed by a related metaphysics.1 Metaphysics for Royce is never a matter of pure theory, but it is presented as a wisdom having practical moral and religious bearing. It is proper to religion to teach some moral code, to inspire a strong feeling of devotion to that code, and in so doing to show something concerning the nature of things.2 While philosophy is not concerned directly with feeling, “both action and belief are direct objects of philosophical criticism.” Thus religious philosophy is concerned with the truth that inspires. It is distinguished from theoretic philosophy precisely by its relation to an ideal. Since ideals are a matter of ethics, religious philosophy properly begins with a study of ethical problems. This study occupies the first book of The Religious Aspect of Philosophy, “The Search for a Moral Ideal.” It is followed in the second book, “The Search for a Religious Truth,” by a metaphysics which considers whether our efforts to realize the ideal find support in the deepest truth of things.
Cloud enabled cognitive radio adhoc vehicular networking (CRAVENET) with security aware resource management and internet of vehicles (IoV) applications

In this paper, we propose to integrate cloud computing into cognitive radio adhoc vehicular networking (CRAVENET) so that the vehicles can share network resources and can benefit wider scope network information for decision making. The proposed architecture includes a cloud enabled CRAVENET. Then, we study the IoV application management system in this cloud enabled CRAVENET. This architecture facilitates to recognize the available resources in real time. Also it provides cloud enabled IoV applications to CRAVENET enabled vehicles. The presented work demonstrates the security protocol in cloud enabled CRAVENET. We propose a distributive and comparative methodology for a secure vehicular network to communicate. We demonstrate the potential of our architecture for real time access of IoV applications in cloud enabled CRAVENET environment.
Tissue Characterization by Ultrasonic Impediography

An analytical method is presented which can be utilized for tissue characterization. This method permits the simultaneous determination of the attenuation and the impedance profiles. Higher-order reflections are included in the formulation. Computer simulated results for a hypothetical case are included.
The Use of Triangulation Methods in Qualitative Educational Research.

Triangulation involves the carejit! reviewing of data collected through different methods in order to achieve a more accurate and valid estimate of qualitative results for a particular construct. This paper describes how we used three qualitative methods of data collection to study attitudes of students toward graphing, hands-on activities, and cooperative grouping techniques using the triangulation method. By Maria Oliver-Hoyo and DeeDee Allen
Motor Decisions Matter — A U.S. Campaign to Encourage Better Motor Management

When a motor fails it is often the first of two failures. The second is the choice of a replacement for the failed motor, usually undertaken in panic mode-with little or no forethought. Research from the U.S. Department of Energy (DOE) shows that only 11 percent of the nation’s corporations plan for motor contingencies. And even in this small group, energy efficiency is rarely a consideration during the decision-making process. This is quite surprising when one considers that the financial and environmental ramifications of these decisions are usually rather significant; many motors remain in service for 20 or 30 years.
The Potential for Astronomy in the Infrared

Infrared Interferometry promises to be a useful astrometric technique. Preliminary measurements of the star α Orionis made with a heterodyne interferometer exhibit phase coherence over a period of at least 1000 seconds. The measurements were equivalent to a positional determination of 60 second accuracy every 5 seconds of integration.
Effect of Pharmacist Clinic Visits on 30-Day Heart Failure Readmission Rates at a County Hospital:

Purpose: This study evaluated the comparative effectiveness of different pharmacist visit types on reducing readmission rates. Method: A single-center, retrospective cohort study was conducted from January 2015 to July 2017. Patients were 18 years or older with an index heart failure (HF) exacerbation admission. Upon hospital discharge, patients were seen in clinic by a clinical pharmacy specialist (CPS) with collaborative practice agreement (CPA) (High Intensity Bundle), medication therapy management (MTM) pharmacist without CPA (Low Intensity Bundle), or no pharmacist (Standard of Care [SOC]). The primary outcome was 30-day all-cause readmission rate. Secondary outcomes included rate of 30-day HF readmissions and average number of days until readmission in those who were readmitted. Results: Totally, 98 patients were included in the final analysis (35 High Intensity Bundle, 28 Low Intensity Bundle, and 35 SOC). The primary outcome of all-cause readmissions was lower in both the pharmacist groups compared with SOC (CPS 8.6% [3/35] vs SOC 25.7% [9/35], P = 0.046 and MTM 7.1% [2/28] vs SOC 25.7% [9/35], P = 0.057). Incremental differences were seen between visit types for the secondary outcome of 30-day HF readmissions (CPS 2.9% vs MTM 7.1% vs SOC 17.1%, P = 0.039). The average number of days until readmission was longer in the CPS versus the MTM and SOC (26.7 days vs 12.5 days vs 14.1 days, respectively). Conclusion: Post-hospital discharge pharmacist visits were associated with lower 30-day all-cause readmission. In particular, clinic visits with a Higher Intensity Bundle may be more effective in reducing HF readmissions. These exploratory findings warrant further investigation.
Bio-mimetic synthetic cell hydrogel magnetometer.

We present a bio-inspired hydrogel magnetometer where the cell potential (V oc) between two hydrogels is used to measure an external magnetic field. Ferromagnetic particles located in the hydrogels move in response to the external field and change the V oc (sensitivity ~ 3.7 V T-1). As the field becomes larger than a critical field B c (~38 mT), these particles puncture the hydrogel boundary shorting out the concentration gradient region and abruptly reducing the V oc (sensitivity ~ 23.5 V T-1). In this regime, the V oc behaves similar to the neuron firing. In subsequent measurement cycles, the particles remain in punctured holes and the sensor behaviour is neuron-like with lower sensitivity (~20 V T-1). V oc also changes as a function of pressure (8 mV kPa-1) and temperature (2 mV K-1). After 4 h, the ionic concentration gradient diminishes in the device, and similar to biological cell fatigue, V oc decreases and can be recharged with many different techniques.
Diurnally Migrating Lunar Water: Evidence From Ultraviolet Data

Data from the Lunar Reconnaissance Orbiter Lyman Alpha Mapping Project and Diviner are consistent with surface water on the Moon varying in abundance with both terrain type and local time/temperature. A thermal desorption model including latitudinally varying desorption activation energy reproduces the observations. We interpret the observed variability in spectral slopes as water molecules in the uppermost lunar regolith (<1% of a monolayer) thermally adsorbing and desorbing from grains depending upon the local temperature and availability of chemisorption sites. The Lyman Alpha Mapping Project data also demonstrate that in the Earth's magnetotail, where the solar wind source of protons is absent, a decrease in H2O on the surface is not observed. This rules out a steady state process involving aprompt solar wind source and favors a migration mechanism for the distribution of adsorbed water onthe Moon.
ASSOCIATION BETWEEN GERIATRIC ELEMENTS AND ORAL ANTICOAGULANT PRESCRIBING AMONG OLDER ADULTS WITH ATRIAL FIBRILLATION: DATA FROM THE SAGE-AF STUDY

Stroke prevention using oral anticoagulants (OAC) is a cornerstone of atrial fibrillation (AF) treatment. Although aging specific risk factors are believed to influence OAC prescribing, this association has not been well studied. The aim of this study was to identify factors related to OAC
A phase II study of nab-paclitaxel in refractory CIMP-high metastatic colorectal cancer.

e14700 Background: Hypermethylation of promoter CpG islands (CIMP) represents a unique pathway for the development of colorectal cancer (CRC). CIMP-high CRC is characterized by the lack of chromoso...
Outcomes of laparoscopic tumor ablation for neuroendocrine liver metastases: a 20-year experience

Since neuroendocrine tumors have an indolent behavior, studies looking at oncologic outcomes should report a long-term follow-up. Over the years, we have been treating selected patients with neuroendocrine liver metastases (NELM) with laparoscopic ablation (LA) and reported favorable local tumor control. The aim of this study is to see whether this local efficacy translates into long-term oncologic outcomes. This was an IRB-approved study of patients who underwent LA for NELM at a single center. Overall and progression-free survivals were analyzed using Kaplan–Meier and Cox proportional hazards model. Study included 58 women and 71 men with a median age of 58 (IQR 47–67) years. Tumor type included carcinoid (n = 92), pancreatic islet cell (n = 28), and medullary thyroid cancer (n = 9). There was a median of 6 (IQR 3–8) tumors, measuring 1.6 (IQR 1.1–2.4) cm. At a median follow-up of 73 (IQR 34–135) months, local liver recurrence per patient, new liver recurrence, and new extrahepatic recurrence rates were 22, 68, and 33%, respectively. Local tumor recurrence per lesion was 5% (n = 42/770). Median overall survival was 125 months, with 5-year, and 10-year overall survivals being, 76%, and 59%, respectively; and median disease-free survival was 13 months, with 5-year, and 10-year progression-free survivals being 26%, and 6%, respectively. On Cox proportional hazards model, overall survival was independently predicted by tumor size, grade, and resection status of primary. To our knowledge, this is the largest single-center experience with the longest follow-up regarding the utilization of LA for NELM. Our results demonstrate that in selected patients, LA achieves a 95% local tumor control and 59% 10-year overall survival.
aPKC drives cilia-independent Hedgehog signaling to maintain basal cell carcinoma growth

Primary cilia loss is a common feature of advanced cancers. While primary cilia are necessary to initiate Hedgehog (HH)-driven cancers, how HH pathway activity is maintained in advanced cancers devoid of primary cilia is unclear. Here, we find that HH-driven basal cell carcinoma (BCC) accumulate mutations in the Alstrom and Usher syndrome genes in advanced and SMO inhibitor-resistant tumors. Loss of Alstrom and Usher syndrome gene expression, which are common underlying causes of deafness and blindness, suppresses ciliogenesis and HH signaling. Atypical protein kinase C iota/lambda (aPKC) is a GLI1 kinase with higher expression in advanced BCCs and we show that a constitutively active isoform drives HH pathway activity and mutually antagonizes primary cilia. Overexpression of the constitutively active aPKC variant can maintain HH pathway activity in the absence of primary cilia and can drive resistance to the SMO antagonist vismodegib regardless of cilia status. Finally, superficial BCCs display less primary cilia and higher aPKC expression, which is inversely correlated in nodular BCC subtypes. Our results suggest aPKC may serve as a biomarker for SMO inhibitor sensitivity and a target for clinical application.
Coactivation pattern analysis reveals altered salience network dynamics in children with autism spectrum disorder.

Brain connectivity studies of autism spectrum disorder (ASD) have historically relied on static measures of functional connectivity. Recent work has focused on identifying transient configurations ...
Nutrition in Adolescent Pregnancy

The rates of adolescent pregnancy are lower than they have ever been, but there were still 229,715 births to teenagers age 15–19 in 2015 (Martin JA, Hamilton BE, Osterman MJ, Driscoll AK, Mathews T, Natl Vital Stat Rep 66(1):1, 2017). Adolescent pregnancies are at increased risks of adverse outcomes, both for mother and child. Poor eating habits in adolescence can compromise intake of nutrients and energy needed for growth, even more so for a pregnant adolescent. The unique concerns regarding adolescent nutrition in pregnancy, including nutritional screening, requirements, recommendations and interventions, are addressed in this chapter.
Effects of Hydroxycinnamates and Exogenous Yeast Assimilable Nitrogen on Cider Aroma and Fermentation Performance

Cider apple cultivars typically contain high concentrations of tannins (phenolic compounds) and/or acids. The phenolic content of some cider apples far exceeds that of white wine grapes, yet modern...
Raman spectroscopy reveals phenotype switches in breast cancer metastasis

The accurate analytical characterization of metastatic phenotype at primary tumor diagnosis and its evolution with time are critical for controlling metastatic progression of cancer. Here, we report a label-free optical strategy using Raman spectroscopy and machine learning to identify distinct metastatic phenotypes observed in tumors formed by isogenic murine breast cancer cell lines of progressively increasing metastatic propensities. Our Raman spectra-based random forest analysis provided evidence that machine learning models built on spectral data can allow the accurate identification of metastatic phenotype of independent test tumors. By silencing genes critical for metastasis in highly metastatic cell lines, we showed that the random forest classifiers provided predictions consistent with the observed phenotypic switch of the resultant tumors towards lower metastatic potential. Furthermore, the spectral assessment of lipid and collagen content of these tumors was consistent with the observed phenotypic switch. Overall, our findings indicate that Raman spectroscopy may offer a novel strategy to evaluate metastatic risk during primary tumor biopsies in clinical patients.
Impact of stress and parenting on respiratory sinus arrythmia trajectories in early adolescence

The effects of stress and parenting on 1-year trajectories of physiological emotion regulation capacity among adolescents were examined. Consistent with the vulnerability-stress and allostatic load models, stress (chronic family and marital) was hypothesized to be associated with less favorable trajectories of basal respiratory sinus arrhythmia (RSA) over 1 year. This relationship was further hypothesized to be moderated by parenting practices (warmth, neglect, and rejection) and adolescent sex. Participants included 150 adolescents (51.3% female), 11-15 years of age (M = 13.04, SD = 0.89). Basal RSA and stress were assessed four times across 1 year. Results indicated a significant decrease in RSA over the course of 1 year (β = -0.15, p = .010). Warm parenting style was associated with lower RSA in environments of low marital stress and was also related with higher RSA in environments of high marital stress (β = 0.86, p = .021). Rejecting parenting styles were associated with higher RSA in environments of low family stress and lower RSA in environments of high family stress (β = -0.60, p = .014). These findings may be explained by the Yerkes-Dodson law of optimal stress, suggesting that sufficient environmental challenge is needed to catalyze regulatory development.
Latinx superheroes in mainstream comics: by Frederick Luis Aldama, Tucson, AZ, University of Arizona Press, 2017, 240 pp., US$22.95 (paperback), ISBN 978-0-8165-3708-2

Frederick Luis Aldama’s Latinx Superheroes in Mainstream Comics offers an encyclopaedic account of Latinx characters in DC and Marvel comic book storyworlds. This book builds on Aldama’s earlier wo...
Patients Undergoing Total Shoulder Arthroplasty on the Dominant Extremity Attain Greater Postoperative ROM

Background Total shoulder arthroplasty (TSA) provides excellent functional outcomes and pain relief in appropriately selected patients. Although it is known to affect other shoulder conditions, the role of hand dominance after TSA has not been reported, to our knowledge.
Face and Palate

The primordia for the lower face develop around the oropharyngeal membrane and form the boundaries of the stomodeum. (The term, stomodeum, refers to the parts of the primitive oral cavity surfaced by ectoderm and receiving their general sensory innervation from the trigeminal nerve.) The five structures which form the boundaries of the stomodeum and which are subsequently involved in facial and palatal development are the: 1. unpaired frontonasal process which forms the upper boundary, 2. paired maxillary processes of the first branchial arch which form the lateral boundaries and 3. paired mandibular processes of the first branchial arch which form the lower boundaries.
N.M.R. studies of electrolytes in binary solvent mixtures

An N.M.R. study of AlCl3, TiCl4 and paramagnetic CoCl2 in water and in aqueous mixtures of acetone, acetonitrile, dimethylacetamide, N,N-dimethylformamide, dimethylsulphoxide, dioxane, ethanol, methanol, N-methylformamide, tetrahydrofuran, and tetramethylurea over a solvent range has been completed. The chemical shift results indicate that although water solvates ions extensively in all the mixtures, many of the organic components, particularly DMSO and the amides, compete effectively with water for added electrolyte. The diamagnetic and the paramagnetic solution results indicate that solvating ability decreases in the order DMSO > alcohols, amides > TMU, THF > acetone, acetonitrile, dioxane. This order correlates well with the basicities of these compounds but not with their dipole moments or dielectric constants.
Student Attitudes about College Consumer Health Products and Problems

(1973). Student Attitudes about College Consumer Health Products and Problems. School Health Review: Vol. 4, No. 6, pp. 15-16.
Beyond the lock icon: real-time detection of phishing websites using public key certificates

We propose a machine-learning approach to detect phishing websites using features from their X.509 public key certificates. We show that its efficacy extends beyond HTTPSenabled sites. Our solution enables immediate local identification of phishing sites. As such, this serves as an important complement to the existing server-based anti-phishing mechanisms which predominately use blacklists. Blacklisting suffers from several inherent drawbacks in terms of correctness, timeliness, and completeness. Due to the potentially significant lag prior to site blacklisting, there is a window of opportunity for attackers. Other local client-side phishing detection approaches also exist, but primarily rely on page content or URLs, which are arguably easier to manipulate by attackers. We illustrate that our certificatebased approach greatly increases the difficulty of masquerading undetected for phishers, with single millisecond delays for users. We further show that this approach works not only against HTTPS-enabled phishing attacks, but also detects HTTP phishing attacks with port 443 enabled.
Putting Security in Context: Visual Correlation of Network Activity with Real-World Information

To effectively identify and respond to cyber threats, computer security analysts must understand the scale, motivation, methods, source, and target of an attack. Central to developing this situational awareness is the analyst’s world knowledge that puts these attributes in context. What known exploits or new vulnerabilities might an anomalous traffic pattern suggest? What organizational, social, or geopolitical events help forecast or explain attacks and anomalies? Few visualization tools support creating, maintaining, and applying this knowledge of the threat landscape. Through a series of formative workshops with practicing security analysts, we have developed a visualization approach inspired by the human process of contextualization; this system, called NUANCE, creates evolving behavioral models of network actors at organizational and regional levels, continuously monitors external textual information sources for themes that indicate security threats, and automatically determines if behavior indicative of those threats is present on a network.
Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment

Diabetic retinopathy (DR) impairs vision of patients with type 1 and type 2 diabetes, associated with vascular dysfunction and occlusion, retinal edema, hemorrhage, and inappropriate growth of new blood vessels. The recent success of biologic treatments targeting vascular endothelial growth factor (VEGF) demonstrates that treating the vascular aspects in the later stages of the disease can preserve vision in many patients. It would also be highly desirable to prevent the onset of the disease or arrest its progression at a stage preceding the appearance of overt microvascular pathologies. The progression of DR is not necessarily linear but may follow a series of steps that evolve over the course of multiple years. Abundant data suggest that diabetes affects the entire neurovascular unit of the retina, with an early loss of neurovascular coupling, gradual neurodegeneration, gliosis, and neuroinflammation occurring before observable vascular pathologies. In this article, we consider the pathology of DR from the point of view that diabetes causes measurable dysfunctions in the complex integral network of cell types that produce and maintain human vision.
Talking the IS Innovation Walk

Talk matters where information technology is concerned; it has consequences. In this conference we as participants take seriously the discourse surrounding IT and its applications. We examine the assumptions embedded in this discourse so as to discern underlying worldviews. We consider discourse both local, as within organizations, and global, as among firms around the world. We thereby probe how our work in researching and applying IT is shaped. Discourse is apparently serious business, especially when it is formal and orderly, as among academics.1