Color Atlas of Nerve Biopsy Pathology

GENERAL CONCEPTS OF PERIPHERAL NEUROPATHY Classification of Peripheral Neuropathy Basic Pathological Mechanism Etiologies of Peripheral Neuropathy Types of Neuropathies Symptoms and Signs Diagnostic Investigations Nerve Conduction Studies and Needle Electromyography Laboratory Studies THE NERVE BIOPSY Indication for the Nerve Biopsy Types of Nerve Biopsy Sural Nerve Biopsy Sequelae of Nerve Biopsy Biopsy of Other Nerves HISTOLOGICAL PROCESSING AND STAINING OF THE BIOPSIED NERVE Treatment of the Biopsied Nerve Immediate Care of the Biopsied Nerve Processing of the Nerve Paraffin Section Stainings Frozen Section Stainings Processing of the Nerve for Semithin and Electron Microscopy Sections Semithin (0.5 - 1mm) Section Stainings Nerve Fiber Teasing Electron Microscope Study NORMAL NERVE: HISTOLOGY Age-Related Changes in the Sural Nerve Biopsy SPECIFIC DIAGNOSTIC PATHOLOGICAL FEATURES OF NERVE BIOPSY Vasculitis Amyloid Deposits Metachromatic Granules Polyglucosan Body Onion-Bulb Formation Inflammatory Cells and Segmental Demyelination INFLAMMATORY CELLS AND AXONAL DEGENERATION Noncaseating Granuloma Necrotizing (Caseating) Granuloma Giant Axons Tomacula Occlusion of Vasa Nervorum Malignant Cells IgM Deposits Segmental Demyelination Axonal Degeneration VASCULITIC NEUROPATHY Vulnerability of the Peripheral Nerve to Vasculitic neuropathy Clinical, Electromyographic, and Laboratory Features Diagnostic Sensitivity of Nerve and Muscle Biopsies Pathology of Vasculitic Neuropathy Pathogenesis of Vasculitic Neuropathy Systemic Necrotizing Vasculitides Vasculitis Associated with Connective Tissue Diseases Nonsystemic Vasculitic Neuropathy Vasculitis in Other Diseases Cases with Vasculitic Neuropathy INFLAMMATORY DEMYELINATING NEUROPATHY Pathogenesis of Inflammatory Demyelinating Neuropathies Guillain-Barre Syndrome (Acute inflammatory Demyelinating Polyneuropathy AIDP) Variants of GBS Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Multifocal Motor Neuropathy (MMN) Multifocal Motor Sensory Demyelinating Neuropathy (MMSDN) Chronic Sensory Demyelinating Neuropathy (CSDN) Cases of Inflammatory Demyelinating Neuropathy IMMUNE-MEDIATED NEUROPATHIES GM1 Antibody-Positive Neuropathy Anti-MAG Associated Neuropathy Neuropathy Associated with Anti-Hu (ANNA 1) Antibody Neuropathy with Monoclonal Gammopathy Cases of Immune-Mediated Neuropathy NEUROPATHIES WITH ABNORMAL DEPOSITS Amyloid Neuropathy Metachromatic Leukodystrophy (Sulfatide Lipidosis Arylsulfatidase Deficiency) Polyglucosan Body Neuropathy Fabry's Disease (Alpha-Galactosidase-A Deficiency) Adrenomyeloneuropathy (AMN) Cases of Neuropathy with Abnormal Deposit HEREDITARY NEUROPATHIES Hereditary Motor and Sensory Neuropathies (HMSN) Hereditary Sensory Neuropathy Hereditary Neuropathy to Pressure Palsy (HNPP) Giant Axonal Neuropathy (GAN) Friedreich's Ataxia METABOLIC AND SYSTEMIC NEUROPATHIES Sarcoid Neuropathy Sensory Perineuritis Leprosy Lymphomatous Neuropathy Diabetic Neuropathy Uremic Neuropathy Alcoholic Neuropathy Hypothyroid Neuropathy Vitamin B12 Deficiency Neuropathy Pyridoxine-Induced Sensory Neuropathy Polyradiculoneuropathy in Lyme Disease AIDS Neuropathy TOXIC NEUROPATHIES Metal Neuropathies Drug-Induced Neuropathy Neuropathy Due to Biological Toxins and Vaccines Toxic Neuropathy Due to Industrial and Environmental Agents Epidemic Toxic Inflammatory Neuropathies Cases of Toxic Neuropathies INTERPRETATION OF NERVE BIOPSY INDEX References are included at the end of each chapter.