cssi/SciSciGPT-SciSciNet huggingface dataset:
A novel, facile, layer-by-layer substrate surface modification for the fabrication of all-inkjet-printed flexible electronic devices on Kapton

A facile, environmentally-friendly, low-cost, and scalable deposition process has been developed and automated to apply polyelectrolyte multilayers (PEMs) on flexible Kapton HN substrates. Two weak polyelectrolytes, poly(acrylic acid) and polyethylenimine, were deposited in an alternating, layer-by-layer fashion under controlled pH and ionic strength. Compared to strong polyelectrolytes, weak electrolytes can control the properties of the PEMs more systmatically and simply. To our knowledge, this work on surface modification of Kapton is not only the first to use only weak polyelectrolytes, but is also the first to take advantage of the surface properties of calcium-bearing additive particles present in Kapton HN. The resulting surface-modified Kapton HN substrate allowed for the inkjet printing of water-based graphene oxide (GO) inks and organic solvent-based inks with good adhesion and with desired printability. While the deposition of a single PEM layer on a Kapton substrate significantly reduced the water contact angle and allowed for the inkjet-printing of GO inks, the deposition of additional PEM layers was required to maintain the adhesion during post-printing chemical treatments. As a conceptual demonstration of the general applicability of this PEM surface modification approach, a flexible, robust, single-layered gas sensor prototype was fully inkjet printed with both water- and ethanol-based inks and tested for its sensitivity to diethyl ethylphosphonate (DEEP), a simulant for G-series nerve agents. The electrical conductivity and morphology of the sensor were found to be insensitive to repeated bending around a 1 cm radius.
Characterization of the CD8+CD45R+(2H4+) suppressor effector cell

In the present study, we have investigated the molecular basis for immunoregulatory function of CD8 cells after autologous mixed lymphocyte reaction (AMLR) activation. We demonstrated that the CD8+CD45R+ but not the CD8+CD45R- subset of cells was a subpopulation, with the majority of suppressor activity after AMLR activation. In contrast, cytotoxic activity against alloantigens resided in both the CD8+CD45R+ and CD8+CD45R- subsets of cells. Importantly, the treatment of AMLR-activated CD8 cells with anti-CD45R antibody or anti-CD3 antibody abolished the suppressor function of these cells, which contrasts with earlier studies showing that treatment of AMLR activated CD4 suppressor inducer cells could be blocked with anti-CD45R but not with anti-CD3 antibody. The results suggest that the CD45R antigen as well as the CD3-T cell receptor (TCR) complex have an important role in the suppressor function of AMLR-activated cells.
LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer.

// Whitney S. Henry 1,* , David G. Hendrickson 2,3,* , Francisco Beca 1 , Benjamin Glass 1 , Marianne Lindahl-Allen 4 , Lizhi He 4 , Zhe Ji 4 , Kevin Struhl 4 , Andrew H. Beck 1 , John L. Rinn 2,3 and Alex Toker 1 1 Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA 2 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA 3 Broad Institute of MIT and Harvard, Cambridge, MA, USA 4 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA * These authors have contributed equally to this work Correspondence to: Alex Toker, email: // John L. Rinn, email: // Keywords : lncRNA, Src, PI3K, breast cancer, LINC00520 Received : March 29, 2016 Accepted : September 02, 2016 Published : September 10, 2016 Abstract Long non-coding RNAs (lncRNAs) have been implicated in normal cellular homeostasis as well as pathophysiological conditions, including cancer. Here we performed global gene expression profiling of mammary epithelial cells transformed by oncogenic v-Src , and identified a large subset of uncharacterized lncRNAs potentially involved in breast cancer development. Specifically, our analysis revealed a novel lncRNA, LINC00520 that is upregulated upon ectopic expression of oncogenic v-Src , in a manner that is dependent on the transcription factor STAT3. Similarly, LINC00520 is also increased in mammary epithelial cells transformed by oncogenic PI3K and its expression is decreased upon knockdown of mutant PIK3CA. Additional expression profiling highlight that LINC00520 is elevated in a subset of human breast carcinomas, with preferential enrichment in the basal-like molecular subtype. ShRNA-mediated depletion of LINC00520 results in decreased cell migration and loss of invasive structures in 3D. RNA sequencing analysis uncovers several genes that are differentially expressed upon ectopic expression of LINC00520, a significant subset of which are also induced in v-Src -transformed MCF10A cells. Together, these findings characterize LINC00520 as a lncRNA that is regulated by oncogenic Src, PIK3CA and STAT3, and which may contribute to the molecular etiology of breast cancer.
Anywhere-Anytime Signals and Systems Laboratory: From MATLAB to Smartphones

A typical undergraduate electrical engineering curriculum incorporates a signals and systems course. The widely used approach for the laboratory component of such courses involves the utilization of MATLAB to implement signals and systems concepts. This book presents a newly developed laboratory paradigm where MATLAB codes are made to run on smartphones, which most students already possess. This smartphone-based approach enables an anywhere-anytime platform for students to conduct signals and systems experiments. This book covers the laboratory experiments that are normally covered in signals and systems courses and discusses how to run MATLAB codes for these experiments on smartphones, thus enabling a truly mobile laboratory environment for students to learn the implementation aspects of signals and systems concepts. A zipped file of the codes discussed in the book can be acquired via the website http://sites.fastspring.com/bookcodes/product/SignalsSystemsBookcodes.
Mixed Linear Regression with Multiple Components

In this paper, we study the mixed linear regression (MLR) problem, where the goal is to recover multiple underlying linear models from their unlabeled linear measurements. We propose a non-convex objective function which we show is {\em locally strongly convex} in the neighborhood of the ground truth. We use a tensor method for initialization so that the initial models are in the local strong convexity region. We then employ general convex optimization algorithms to minimize the objective function. To the best of our knowledge, our approach provides first exact recovery guarantees for the MLR problem with $K \geq 2$ components. Moreover, our method has near-optimal computational complexity $\tilde O (Nd)$ as well as near-optimal sample complexity $\tilde O (d)$ for {\em constant} $K$. Furthermore, we show that our non-convex formulation can be extended to solving the {\em subspace clustering} problem as well. In particular, when initialized within a small constant distance to the true subspaces, our method converges to the global optima (and recovers true subspaces) in time {\em linear} in the number of points. Furthermore, our empirical results indicate that even with random initialization, our approach converges to the global optima in linear time, providing speed-up of up to two orders of magnitude.
Conformational Evolution of Three Regulator of G-Protein Signaling Proteins (RGS4, RGS8, RGS19) in Microsecond-Scale Simulations

Regulators of G protein signaling (RGS) proteins modulate GPCR signaling by binding to Gα-subunits of heterotrimeric G proteins and accelerating hydrolysis of GTP. Therefore, RGS proteins are becoming increasingly important therapeutic targets to be directly or allosterically inhibited from binding to Gα-subunits. While structures of several known RGS proteins are highly similar and largely contain α-helical motifs, some thiadiazolidinone (TDZD) compounds that target cysteine residues have shown different levels of specificities and potencies for closely related proteins thereby suggesting intrinsic differences in dynamics of these proteins. In this work, we have studied the dynamics of three different RGS proteins (apo-RGS4, apo-RGS8, and apo-RGS19) using microsecond-scale classical molecular dynamics (MD) simulations with CHARMM and AMBER force-fields. Analyses of these trajectories reveal high fluctuations in α5 and α6 helices and the loops connecting them. These fluctuations lead to perturbations in residues in the RGS-Gα interface and in the vicinity of cysteines that are targets of allosteric inhibitors. These findings have significant implications for understanding differences in potencies and specificities of inhibitory small-molecules.
Synergistic effect of fluoride and laser irradiation for the inhibition of the demineralization of dental enamel.

Both laser irradiation and fluoride treatment alone are known to provide increased resistance to acid dissolution. CO2 lasers tuned to a wavelength of 9.3 μm can be used to efficiently convert the carbonated hydroxyapatite of enamel to a much more acid resistant purer phase hydroxyapatite (HAP). Further studies have shown that fluoride application to HAP yields fluoroapatite (FAP) which is even more resistant against acid dissolution. Previous studies show that CO2 lasers and fluoride treatments interact synergistically to provide significantly higher protection than either method alone, but the mechanism of interaction has not been elucidated. We recently observed the formation of microcracks or a “crazed” zone in the irradiated region that is resistant to demineralization using high-resolution microscopy. The microcracks are formed due to the slight contraction of enamel due to transformation of carbonated hydroxyapatite to the more acid resistant pure phase hydroxyapatite (HAP) that has a smaller lattice. In this study, we test the hypothesis that these small cracks will provide greater adhesion for topical fluoride for greater protection against acid demineralization.
IT-Unterstützung zur Umsetzung moderner Managementmethoden — Die Balanced Scorecard und ihre IT-technische Realisierung

Der Ubergang vom Industrie-zum Informationszeitalter hat fur die meisten Unternehmen vollig neue Rahmenbedingungen geschaffen: Fur den Wettbewerb in der globalen Okonomie sind neue unternehmerische Fahigkeiten gefragt — allein mit dem altgedienten Rezept „Kostensenkung„ kann heute kein Unternehmen mehr Wettbewerbsvorteile generieren. Ein echter Vorsprung gegenuber dem Mitbewerb gelingt nur dann, wenn Wachstumspotentiale im Unternehmen identifiziert und optimal genutzt werden — und zwar in allen Geschaftsbereichen. Fur diese komplexe Aufgabe konzipierten Robert S. Kaplan und David P. Norton die Balanced Scorecard, ein Managementkonzept, das neben den harten Finanzzahlen auch sogenannte weiche Faktoren fur die Bewertung unternehmerischen Erfolges ins Visier nimmt Das ausgewogene Unternehmensbild liefert Informationen uber die Zufriedenheit von Mitarbeitern und Kunden sowie Fahigkeiten eines Unternehmens, vorhandenes Wissen auszuschopfen und Innovationschancen zu erkennen. Was 1992 als konzeptioneller Ansatz formuliert wurde, last sich heute bereits - auf der Basis von Data Warehouses, kombiniert mit leistungsfahigen Analysewerkzeugen realisieren (die Methodik der Balanced Scorecard wurde an anderer Stelle bereits ausfuhrlich beschrieben: vgl. Kaplan/Norton 1997a; 1997b; Seidenschwarz 1999; Schwab 1999; deshalb sei sie nachfolgend nur kurz angesprochen). [1][2][3][4]
Special Considerations in the Psychiatric Evaluation of Sexual Offenders against Minors

The first priest approached the bishop and asked, “Father, may I smoke while praying?” to which the bishop responded, “I’m sorry, my son, but that is not permitted.” The second priest, having overheard the conversation, thought for awhile before going to the bishop a few weeks later to ask, “Father, may I pray when smoking?” to which the bishop replied, “Of course, my son, of course.”
The Disposability of Baltimore’s Black Communities: A Participatory Action Research Project on the Impact of School Closings

This article presents the results of a participatory action research project about the impact of the closings on the parents, teachers, and students experiencing school closure. Using participatory action research methods, the researcher, the author of this article, and a community-based organization worked together in “contingent collaboration” to surface a counter-narrative about school closings which was used to critique and ultimately advocate against the policy of school closings. While the research was used for advocacy, it is also analyzed by this researcher to demonstrate the possibilities of the participatory action research to counter to neoliberal discourses prevalent in research on urban schools and communities, which paint those communities as damaged and in need of fixing. It uses the work of critical race theorists as a lens to view the school closings, pointing out that educational inequalities always have a racial component. At the same time, the article also reveals the pitfalls of this kind of research, showing that the collaboration between a white university researcher and a community-based, youth of color-led organization cannot be truly free of racism and white hegemony, even when trying to expose it in a policy reform.
Integrating Bayesian genomic cline analyses and association mapping of morphological and ecological traits to dissect reproductive isolation and introgression in a Louisiana Iris hybrid zone

Hybrid zones provide unique opportunities to examine reproductive isolation and introgression in nature. We utilized 45,384 single nucleotide polymorphism (SNP) loci to perform association mapping of 14 floral, vegetative and ecological traits that differ between Iris hexagona and Iris fulva, and to investigate, using a Bayesian genomic cline (BGC) framework, patterns of genomic introgression in a large and phenotypically diverse hybrid zone in southern Louisiana. Many loci of small effect size were consistently found to be associated with phenotypic variation across all traits, and several individual loci were revealed to influence phenotypic variation across multiple traits. Patterns of genomic introgression were quite heterogeneous throughout the Louisiana Iris genome, with I. hexagona alleles tending to be favoured over those of I. fulva. Loci that were found to have exceptional patterns of introgression were also found to be significantly associated with phenotypic variation in a small number of morphological traits. However, this was the exception rather than the rule, as most loci that were associated with morphological trait variation were not significantly associated with excess ancestry. These findings provide insights into the complexity of the genomic architecture of phenotypic differences and are a first step towards identifying loci that are associated with both trait variation and reproductive isolation in nature.
Outpatient Billing and Coding

Generating maximum revenue is important to all medical practices including the ones in academic centers. This chapter will review the basics of outpatient billing and coding and discuss ways to maximize work revenue value units (wRVUs).
Asymmetric Dimethylarginine Impairs Nitric Oxide Bioavailability and Jeopardizes Cardio-Sexual Function

Asymmetric dimethylarginine (ADMA), a natural byproduct of protein metabolism in all body cells, is a substance found in blood plasma. It is now generally recognized that because ADMA is a nitric oxide (NO) antagonist, it may promote the progression of cardiovascular diseases (CVDs), including hypertension, atherosclerosis, chronic heart failure, coronary artery disease (CAD), type-2 diabetes, and erectile dysfunction (ED). It’s principal adverse effect is thought to be uncoupling of the enzyme endothelial nitric oxide synthase (eNOS).
Asymmetry of Body and Brain

Advances in computational analysis, imaging, and genetics along with increasingly sophisticated research paradigms have brought about an across-the-life-span, if not also an evolutionary, perspective in body and brain laterality research. In addition, a simple or naive structural localizationist approach to asymmetry in brain and body has given way to a developmental and physiological perspective. Evidence shows that asymmetries of body and brain are established early and share basic molecular pathways that are evolutionarily well conserved. That said, some genes show altered (asymmetric) expression levels in human brains and endow the brain unlike the viscera with lifelong adaptability.
HIDDEN STRUCTURE IN LINEAR PROGRAMS

Publisher Summary This chapter discusses hidden structure in linear programs and describes an approach based primarily on graph theory and elementary linear algebra for uncovering network structure in linear programs (LPs). Network problems, in particular, can be solved much faster and with far smaller storage requirements than conventional LPs. A hidden network problem is any LP, which is convertible to a network problem. If A is a network matrix, M(A) is said to be graphic. M(A) is binary if A is a (0,1)-matrix and row operations are defined using module 2 arithmetic. Binary matroids provide a stepping stone between general matroids and graphic matroids.
Social factors as driving forces: Towards interdisciplinary models of global change

Homo sapiens is not so fortunate as to have its ecological challenges be separate, distinct and amenable to simple solutions. Biodiversity loss and climate change are examples. The loss of biodiversity is a significant ecological problem, and an important component of global environmental change (Ehrenfeld, 1972; Soule, 1986; Wilson, 1988a; Lovejoy, 1988; NRC, 1992). The major cause of biodiversity loss is human action, primarily land-use that alters habitat (Pimm and Gilpin, 1989; Freedman, 1989). Climate change is also a critical ecological problem (Peters and Lovejoy, 1992; Gable et al., 1990; Peters, 1988), and anthropogenic factors such as fossil fuel use and release of trace gases are now considered significant driving forces (NRC, 1992; Goodess et al., 1992; Glantz and Krenz, 1992). Further, there are important linkages between climate change and biodiversity loss (Peters and Lovejoy, 1992; Root and Schneider, 1993), and these relationships are often interactive, indirect and nonlinear.
An Overview of Mixed-Signal, Embedded System Design

This chapter is intended to serve as an introduction to embedded mixed-signal systems and discusses:
Distributed Joins and Data Placement for Minimal Network Traffic

Network communication is the slowest component of many operators in distributed parallel databases deployed for large-scale analytics. Whereas considerable work has focused on speeding up databases on modern hardware, communication reduction has received less attention. Existing parallel DBMSs rely on algorithms designed for disks with minor modifications for networks. A more complicated algorithm may burden the CPUs but could avoid redundant transfers of tuples across the network. We introduce track join, a new distributed join algorithm that minimizes network traffic by generating an optimal transfer schedule for each distinct join key. Track join extends the trade-off options between CPU and network. Track join explicitly detects and exploits locality, also allowing for advanced placement of tuples beyond hash partitioning on a single attribute. We propose a novel data placement algorithm based on track join that minimizes the total network cost of multiple joins across different dimensions in an analytical workload. Our evaluation shows that track join outperforms hash join on the most expensive queries of real workloads regarding both network traffic and execution time. Finally, we show that our data placement optimization approach is both robust and effective in minimizing the total network cost of joins in analytical workloads.
Comparison of Sacral-Alar-Iliac and Iliac-Only Methods of Pelvic Fixation in Early-Onset Scoliosis at 5.8 Years' Mean Follow-up.

Abstract Study Design Retrospective. Objective Compare clinical outcomes in early-onset scoliosis (EOS) patients treated with sacral-alar-iliac (SAI) versus iliac-only methods of pelvic fixation at two years' minimum follow-up. Summary of Background Data Pelvic fixation in EOS is challenged by poor bone, anchor migration, and displacement. The long-term outcomes of SAI fixation in EOS is unknown. Methods We retrospectively reviewed EOS patients in a single center from 2000 to 2017. Inclusion criteria were posterior spinal instrumentation with pelvic fixation before age 10 and 2 years' minimum follow-up. Clinical and radiographic data were analyzed using chi-squared and Student t tests (significance defined as p Results Seven subjects were included in the iliac-only fixation group (Galveston technique = 2, iliac screws = 5) and 17 in the SAI group. For the iliac-only group (mean follow-up = 6.8 years), pelvic obliquity improved from a mean of 18° at initial presentation to 11° at first instrumentation (p = .096), to 9° at end follow-up (p = .060), whereas the major curve improved correspondingly from a mean of 84° to 50° (p = .002) to 39° (p = .006). For the SAI group (mean follow-up = 5.5 years) at the same time points, pelvic obliquity improved from a mean of 25° to 6° (p Conclusions In EOS patients at 2 years' minimum (5.8 years' mean) follow-up, both SAI and iliac-only methods corrected major curve, only SAI fixation corrected pelvic obliquity, and neither was associated with pelvic growth disturbances. SAI fixation was also associated with fewer complications. These findings may be due to the length and direction of the SAI anchors and abutment on the iliac cortex. Level of Evidence Level III.
Physics-Based Acoustic Source Identification

In this paper we propose an acoustic source identification algorithm to localize multiple sources in non-trivial domains. We capture the physics of the acoustic wave propagation via the Helmholtz partial differential equation. Given a set of noisy complex pressure measurements of an acoustic field, we formulate an optimization problem to solve for the locations, shapes, and intensities of the sources that minimize the discrepancy between the observed pressure measurements and those predicted by the model. We parametrize each source with a nonlinear function that depends on a small set of parameters, greatly reducing the dimension of the problem. We present an initialization method for the resulting nonlinear optimization problem. We present experimental results showing the ability of our method to correctly identify multiple acoustic sources in a free field domain as well as a domain with obstacles and reflecting boundaries. Moreover, we show that our method can identify more interesting properties of the source field, such as relative phase difference between sources.
A Directional Detector Response Function for Anisotropic Detectors

AbstractFor a radiation detector that is not isotropic, a directional detector response is needed to accurately account for the variation in a detector’s behavior depending on the incoming particle...
The origin of amniotic fluid monocytes/macrophages in women with intra-amniotic inflammation or infection

Background Monocytes, after neutrophils, are the most abundant white blood cells found in the amniotic cavity of women with intra-amniotic inflammation/infection. However, the origin of such cells has not been fully investigated. Herein, we determined (1) the origin of amniotic fluid monocytes/macrophages from women with intra-amniotic inflammation/infection, (2) the relationship between the origin of amniotic fluid monocytes/macrophages and preterm or term delivery and (3) the localization of monocytes/macrophages in the placental tissues. Methods Amniotic fluid samples (n = 16) were collected from women with suspected intra-amniotic inflammation or infection. Amniotic fluid monocytes/macrophages were purified by fluorescence-activated cell sorting, and DNA fingerprinting was performed. Blinded placental histopathological evaluations were conducted. Immunohistochemistry was performed to detect CD14+ monocytes/macrophages in the placental tissues. Results DNA fingerprinting revealed that (1) 56.25% (9/16) of amniotic fluid samples had mostly fetal monocytes/macrophages, (2) 37.5% (6/16) had predominantly maternal monocytes/macrophages and (3) one sample (6.25% [1/16]) had a mixture of fetal and maternal monocytes/macrophages. (4) Most samples with predominantly fetal monocytes/macrophages were from women who delivered early preterm neonates (77.8% [7/9]), whereas all samples with mostly maternal monocytes/macrophages or a mixture of both were from women who delivered term or late preterm neonates (100% [7/7]). (5) Most of the women included in this study presented acute maternal and fetal inflammatory responses in the placenta (85.7% [12/14]). (6) Women who had mostly fetal monocytes/macrophages in amniotic fluid had abundant CD14+ cells in the umbilical cord and chorionic plate, whereas women with mostly maternal amniotic fluid monocytes/macrophages had abundant CD14+ cells in the chorioamniotic membranes. Conclusion Amniotic fluid monocytes/macrophages can be of either fetal or maternal origin, or a mixture of both, in women with intra-amniotic inflammation or infection. These immune cells could be derived from the fetal and maternal vasculature of the placenta.
Five Point Energy Minimization: A Synopsis

This paper is a condensation of my arXiv monograph entitled Schwartz “The phase transition in 5 point energy minimization”, 2016. arXiv:1610.03303, which contains a complete proof that there is a constant such that the triangular bi-pyramid is the minimizer, amongst all 5 point configurations on the sphere, with respect to the power law potential $$R_s(r)=\mathrm{sign}(s)/r^s$$, if and only if . In this paper we explain the main ideas and give proofs for some of the key lemmas.
A Relational Conception of Emotional Development

In this article, I outline a relational-developmental conception of emotion that situates emotional activity within a broader conception of persons as holistic, relational beings. In this model, em...
The Effect of the Battery Efficiency on the Customer’s Optimum Demand Load Profile

Considering the notable interest in the renewables integration to the power grids, especially the small-scale batteries in the residential sector, the efficiency of the batteries is one of the most important factors that should be considered. Several factors affect the efficiency of the battery and its lifetime such as temperature, aging, and the battery’s charge and discharge profile. In this paper we consider the effect a small-scale battery’s efficiency and lifetime on its performance during its connection to the power grid. It is shown that the battery performance in the power grid is highly affected by its efficiency. Also. it is shown that battery integration under certain efficiency is no longer beneficial for the grid and the battery owner.
Prevalence of and Associations With Distress and Professional Burnout Among Otolaryngologists: Part I, Trainees

ObjectiveTo assess the prevalence of distress and burnout in otolaryngology trainees, including associations with relevant sociodemographic and professional factors, and to compare these results wi...
Broadband phononic frequency comb generation in a parametrically excited capacitive micromachined ultrasonic transducer

Optical frequency combs consisting of evenly spaced discrete frequencies have been used for a number of applications such as frequency metrology, range finding and molecular fingerprinting. Recently, the acoustic equivalent of these frequency combs, known as phononic frequency combs (PFCs), have been demonstrated in micro and nanoscale resonators. However, such demonstrations are restricted to PFC generation in high-Q mechanical resonators under carefully controlled operating conditions with limited practical applications. In this work, we demonstrate a novel method of generating PFCs with a parametrically driven capacitive micromachined ultrasonic transducer (CMUT) operating in a fluid medium. The proposed system consists of an electrically driven CMUT array that forms part of a resonant RLC circuit of frequency w0. By applying two drive tones of frequency w0 and w0+Δ, we are able to generate broadband acoustic frequency combs via a parametric four-wave mixing process. The intensity and number of combs generated is strongly dependent on the relative strength of the two driving tones whereas the comb spacing is determined by the frequency difference Δ between the drive signals. We also briefly discuss a potential application of PFCs in extended non-ambiguous range (NAR) distance metrology with interferometric resolution.
Renewal: Liberal Protestants and the American City After World War II: by Mark Wild, Chicago, University of Chicago Press, 2019, 336pp., US$50.00 (hardback), ISBN 978 0 2266 0523 4

With texts such as Robert Orsi’s Madonna of 125th Street still at the forefront of the American religion canon, and with more recent works by Bethany Moreton, Timothy Gloege, Chad Seales, and many ...
Supports and Barriers for the Implementation of the Olweus Bullying Prevention Program in Urban Middle Schools in Low-Income Areas

Identifying factors that help or hinder the implementation of school environment interventions such as the Olweus Bullying Prevention Program (OBPP) is needed to inform strategies that bolster implementation quality in low-income urban middle school settings. We used qualitative methods to identify supports and barriers for OBPP implementation from the perspective of administrators, Bullying Prevention Coordinating Committee members, and teaching staff at two urban middle schools in low-income attendance zones that primarily served African-American adolescents. Interviews and focus groups with 42 participants (Mage = 46; 74% female; 79% African-American) yielded seven themes that impeded OBPP implementation: (1) lack of time, (2) unanticipated changes and events, (3) varying staff commitment and implementation consistency, (4) school context, climate, and structural changes, (5) difficulty identifying bullying incidents, (6) social media influences that exacerbated bullying behaviors, and (7) limited fiscal and staff resources. Participants also identified four themes that supported implementation: (1) endorsing the OBPP as seen by administrator prioritization of the program and staff presence, involvement, and commitment, (2) staffs’ clear communication about OBPP roles and responsibilities, and teamwork and collaboration within and across levels of organizational leadership, (3) intervention dynamics (e.g., flexibility in class meeting delivery), and (4) logistics such as having support materials for class meetings and staffing resources. These findings inform OBPP efforts, especially those focused on enhancing program implementation in urban middle school settings located in low-income areas.
Comparison of Lumbar and Ventricular Cerebrospinal Fluid for Diagnosis and Monitoring of Meningitis

Severe meningitis, especially basilar meningitis, can lead to hydrocephalus requiring external ventricular drain (EVD) placement. There are differences in cerebrospinal fluid (CSF) obtained from an...
The psychology of philosophy: Associating philosophical views with psychological traits in professional philosophers

Do psychological traits predict philosophical views? We administered the PhilPapers Survey, created by David Bourget and David Chalmers, which consists of 30 views on central philosophical topics (...
Indocyine Green (ICG) Enhanced Shortwave Infrared Fluorescence Imaging at Video Rate

We present a system for ICG-enhanced fluorescence imaging in the shortwave infrared (SWIR) range. Imaging performance and validation studies performed using an in vivo mouse model, as well as broader clinical outlooks, are discussed.
A Guide to Real Variables

A Guide to Real Variables provides aid and conceptual support for the student studying for the qualifying exam in real variables. Beginning with the foundations of the subject, the text moves rapidly but thoroughly through basic topics like completeness, convergence, sequences, series, compactness, topology and the like. All the basic examples like the Cantor set, the Weierstrass nowhere differentiable function, the Weierstrass approximation theory, the Baire category theorem, and the Ascoli-Arzela theorem are treated. The book contains over 100 examples, and most of the basic proofs. It illustrates both the theory and the practice of this sophisticated subject. Graduate students studying for the qualifying exams will find this book to be a concise, focused and informative resource. Professional mathematicians who need a quick review of the subject, or need a place to look up a key fact, will find this book to be a useful resource too. Steven Krantz is well-known for his skill in expository writing and this volume confirms it. He is the author of more than 50 books, and more than 150 scholarly papers. The MAA has awarded him both the Beckenbach Book Prize and the Chauvenet Prize.
Parsimonious Determination of the Optimal Infectious Dose of a Pathogen for Nonhuman Primate Models

The nonhuman primate (NHP) model is often the best experimental model for testing interventions designed to block infection by human pathogens, such as HIV, tuberculosis, and malaria. A physiological model may require the use of a limiting dose of the infectious agent, where only a fraction of animals become infected upon any given challenge. Determining the challenge dose of the pathogen in such experiments is critical to the success of the experiment: using too-high or too-low a challenge dose may lead to false negative results and an excessive use of animals. Here I define an optimized protocol for defining the dose of pathogen that infects 50% of the time (AID50); other challenge doses, e.g. AID80, can be easily calculated from the same data. This protocol minimizes the number of animals, as well as resources and procedures, while providing an estimate of the AID50 within 1.5-fold of the true value.
Frontiers in Chemical Engineering Research and Opportunities

Dear professional colleagues, researchers, engineers and students, I am pleased to introduce the first issue of Journal of Chemical Engineering Research Studies (JCERS). The successful launching of this Journal is the outcome of the authors, professional, dedicated reviewers, editorial boards and collective input from the editorial board members. We are quite hopeful to receive the support and guidance from these eminent scientists / professors for rapid growth of JCERS. Today chemical engineering and allied technologies are state of the art. In order to explore and develop sustainable process with high profitability, researchers are focusing on micro and/or nano (or molecular) levels. The ongoing development inmicro and nano technology and the increasing power of characterization equipment have led to a technical revolution in industry and everyday life. Beside automation and computingmicro fabrication is booming. This has helped to buildminiaturized chemical engineering to microfluidics andmicro reaction technology. This is an exotic experimental field that has broughtmicro scale devices into the industry. The conventional continuous-flow chemistry in industrial environment is being revisited in laboratories to match the requirements. These technologies have the source of improvement in the control of reactors and overall process. Online optimization for enhanced yields is a reality. The perspectives of improved process design, performancesand live operating strategies have helped towards the acceptance of sophisticated commercial technology.
A rewrite rule based approach for synthesizing abstract data types

An approach for synthesizing data type implementations based on the theory of term rewriting systems is presented. A specification is assumed to be given as a system of equations; an implementation is derived from the specification as another system of equations. The proof based approach used for the synthesis consists of reversing the process of proving theorems (i.e. searching for appropriate theorems rather than proving the given ones). New tools and concepts to embody this reverse process are developed. In particular, the concept of expansion, which is a reverse of rewriting (or reduction), is defined and analyzed. The proposed system consists of a collection of inference rules — instantiation, simplification, expansion and hypothesis tesing, and two strategies for searching for theorems depending upon whether the theorem being looked for is in the equational theory or in the inductive theory of the specification.
Activator of G-protein signaling 3 (AGS3) binds GRK6 via its G-protein (GPR) domain to modulate CXCR2 mediated cellular responses. (CCR5P.261)

AGS3, a receptor-independent activator of G-protein signaling, comprises of seven tetratricopeptide (TPR) motifs and four GPR motifs joined by a linker sequence. Previous studies have demonstrated that TPR domain of AGS3 is important for determining the positioning of AGS3 within the cell, whereas, GPR domain serves as a docking site for Gα i -GDP leading to AGS3-Gα i signaling. We have recently shown that GRK6 complexes with AGS3-Gα i to regulate CXCR2-mediated cellular functions including Ca 2+ mobilization, mitogen-activated protein kinase (MAPK) activation, receptor desensitization and down-regulation. In the current study mutants from the GPR and TPR domains were used to determine which motif(s) of AGS3 is (are) involved in binding with GRK6. Co-imunoprecipitation studies in RBL cells co-transfected with wild type and mutants AGS3 showed that, upon stimulation with interleukin 8 (IL-8/CXCL8), GRK6 interacts with the GPR domain of AGS3. Overexpression of AGS3 and the GPRs motif (ΔTPR7-link), but not the TPRs motif (TPR), in RBL-CXCR2 inhibited CXCL8-induced intracellular Ca 2+ mobilization and MAPK activation. Taken together, these results indicated that AGS3 binds to GRK6 via the GPR domain to modulate CXCR2-mediated signal transduction.
The Study of Chemical Communication in Free-Ranging Mammals

Although investigations into chemical communication in vertebrates have been conducted for a long period, this field of study actually came of age only a year or so ago, with the founding of the Journal of Chemical Ecology. The relatively delayed development of the field resulted from the extreme difficulty encountered in attempting to cope with its subject matter.
Wear Minimization for Cuckoo Hashing: HowäNotätoäThrowäaäLotäofäEggsäintoäOneäBasket

We study wear-leveling techniques for cuckoo hashing, showing that it is possible to achieve a memory wear bound of loglogn + O(1) after the insertion of n items into a table of size Cn for a suitable constant C using cuckoo hashing. Moreover, we study our cuckoo hashing method empirically, showing that it significantly improves on the memory wear performance for classic cuckoo hashing and linear probing in practice.
Bovine Pancreatic Deoxyribonucleases A and C A PROLINE FOR HISTIDINE SUBSTITUTION IN DEOXYRIBONUCLEASE C

Abstract Peptide maps obtained with tryptic-chymotryptic hydrolysates of bovine pancreatic DNases A, B, and C show a high degree of similarity. The map for DNase C, however, shows one peptide to have moved to a significantly less basic position. The peptide in question was isolated from hydrolysates of A and C and its sequence determined in each instance. The results show that DNase C contains a proline residue at the position occupied by histidine-118 in the 257-residue sequence of DNase A. The results confirm the conclusion, initially based on the amino acid compositions of DNases A and C, that the two forms differ by a residue change that could arise from a single base change in the relevant gene. Histidine-118 in DNase A is thus not a residue essential to the activity of the enzyme.
Pipelining for speed doubling in MDFE

The data rate in decision feedback detectors is often limited by the time it takes the slicer to make a decision, followed by generating an output value from the decision feedback filter and finally establishing the input of the slicer for the next symbol period. It is shown that the equalized dibit response for multi-level decision feedback equalization can be designed so that the first tap of the feedback filter is 0, thereby allowing the operations of the critical path to be spread over 2 symbol periods. By eliminating the first coefficient of the feedback filter, an architecture which doubles the overall symbol rate by using 2 decision feedback detectors each operating at one-half the symbol rate is realizable. Architectural considerations for determining the error required in the LMS adaptation of the timing, gain and feedback equalizer are described.
Maturing masculinities: aging, chronic illness and Viagra in Mexico.

In what ways do older Mexican men experiencing decreasing erectile function conceive of themselves as men within a sociocultural milieu that valorizes penetrative sex as an embodied affirmation of ...
Methylenetetrahydrofolate Reductase 677C→T Polymorphism and Folate Status Affect One-Carbon Incorporation into Human DNA Deoxynucleosides

The methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism is thought to influence the partitioning of 1-carbon units between methylation and other components of 1-carbon metabolism and to influence the risk and etiology of several major cancers and cardiovascular disease. Our objective was to determine the effect of the MTHFR 677C-->T polymorphism and folate status on the relative rate and extent of in vivo synthesis of DNA precursors. Adequately nourished, healthy women (9 CC, 9 TT) were infused with [3-(13)C]serine and [(13)C(5)]methionine for 9 h before and after 7 wk of consumption of a low-folate diet. Blood was drawn over 5 d for monocyte DNA isolation. Isotopic enrichment of the nucleosides in DNA digests was determined by LC-MS/MS. Maximum thymidine enrichment tended to be higher (P = 0.07) in TT than in CC subjects, suggestive of marginally higher mean thymidylate synthesis. However, the subset of TT subjects who exhibited formyltetrahydrofolate in erythrocytes (an indicator of 1-carbon partitioning) had greater (P = 0.036) thymidine enrichment than CC subjects, who had no erythrocyte formyltetrahydrofolate. Purine enrichment was not affected by genotype or folate depletion. However, the deoxyadenosine to deoxyguanosine enrichment ratio was significantly higher in TT subjects, suggesting a greater relative rate of adenine synthesis. The approximately 40% greater (P = 0.012) labeling of the methyl group of methyldeoxycytidine during folate depletion suggests a change in the origin of this 1-carbon unit. This is the first time that 1-carbon incorporation into human DNA has been measured in vivo after infusion of (13)C-labeled 1-carbon precursors. These findings support the feasibility of further assessment of factors affecting deoxynucleotide synthesis and DNA methylation in human 1-carbon metabolism.
Platonic Dialogues, Socratic Inquiries: A Symposium on Plato's Philosophers

Interpreting a Platonic dialogue is a labor of love for those seeking wisdom. In her book Plato's Philosophers: The Coherence of the Dialogues, 1 Catherine Zuckert has taken on a labor of Herculean...
High-resolution locations of triggered earthquakes and tomographic imaging of Kilauea Volcano's south flank

[1] The spatiotemporal patterns of seismicity beneath Kilauea's south flank give insight to the structure and geometry of the decollement on which large, tsunamigenic earthquakes have occurred, and its relation to slow slip events (SSEs), which have been observed every 1 to 2 years since 1997. In order to record earthquakes triggered by a SSE that was predicted to occur in March 2007, a temporary network of 20 seismometers was deployed on Kilauea's south flank, termed the SEQ network. While the SSE did not occur until 17 June 2007, theSEQ network recorded over 3000 earthquakes, including those triggered by the SSE. We relocate hypocenters of volcano-tectonic earthquakes and invert for P and S wave velocity structure using waveform cross-correlation and double-difference tomography using data from the SEQ network and the permanent Hawaii Volcano Observatory network (HVO) data, with additional data from other previous temporary arrays. The best-constrained hypocenters, recorded by both the SEQ and HVO networks, indicate the decollement as a subhorizontal layer of seismicity at 8 km depth less than 1 km thick in most areas, with the western portion of the decollement dipping to the southeast. The seismicity triggered by the June 2007 SSE includes over 400 earthquakes overlapping with the southern edge of the decollement seismicity. A shallower swarm of earthquakes also occurred between 2 and 7 km depth in April 2007 near Apua Point, and may have been indirectly triggered by the Mw 8.1 Solomon Islands earthquake at ∼6000 km distance, which occurred 48 h prior to the beginning of the swarm.
Recent Developments with the Thin-Heater Thermal Conductivity Apparatus

A thin-foil heating element is employed in a thermal conductivity apparatus that operates in accordance with the basic concept of the guarded hot plate. The metal foil is sufficiently thin that lateral heat flow along the plane of the heater is insignificant, at least in the central region, so there is no need for isola tion and separate temperature control of a guard region. This makes the appa ratus simple and inexpensive to construct and operate. The resultant low-mass configuration minimizes drift error and usually reaches steady state in less than 30 min with 0.5-cm-thick specimens of nonmetallic solids. Thermal conductivity values are calculated on an absolute basis with an estimated accuracy of ±3%.Speed and simplicity make the apparatus well suited for product-development and quality control applications. Because temperature differences within the sample do not exceed a few degrees, uncertainty in mean sample temperature is sharply limited, water-vapor-migration problems are minimized, and thermal...
DNA topoisomerase II isozymes involved in anticancer drug action and resistance

DNA topoisomerase II is a major protein of the nuclear matrix. The enzyme appears to have a central role in both DNA organization and replication. The importance of nuclear matrix topoisomerase II alpha as a target for certain anticancer agents was evaluated in CEM human leukemia cells. Studies were done to determine the extent to which the alpha (170 kDa) and beta (180 kDa) isozymes of topoisomerase II form covalent enzyme-DNA complexes in whole cells and in the nuclear matrix and nonmatrix fractions of CEM cells that are either sensitive or resistant to topoisomerase II-active anticancer agents. Topoisomerase II alpha was detected in both the high salt-soluble (nonmatrix) and matrix fractions of nuclei from parental CEM cells. Most of the matrix topoisomerase II alpha was tightly bound to DNA in cells incubated with VM-26. In contrast, topoisomerase II beta was detected only in the high salt-soluble (nonmatrix) fraction of the nucleus. The subnuclear distribution of the alpha and beta topoisomerase II isozymes in CEM/VM-1 cells resistant to topoisomerase-active drugs was similar to that in drug-sensitive CEM cells. However, the amount and activity of topoisomerase II alpha in nuclear matrices of CEM/VM-1 cells were decreased 3- to 6-fold relative to that of CEM cells. The differences observed in the subnuclear distribution and DNA binding pattern of the topoisomerase II isozymes support the hypotheses that each isozyme has a distinct cellular function. Furthermore, these results provide evidence that topoisomerase II alpha is the nuclear matrix target for VM-26, and that depletion of the nuclear matrix isozyme contributes to cellular resistance to this anticancer agent.