cssi/SciSciGPT-SciSciNet huggingface dataset:
Using graphics research to teach freshman computer science

Although research is often a daunting task for undergraduates, early exposure to research topics and papers can be an effective means of stimulating interest and teaching students about realworld solutions to non-trivial problems. To that end, we have initiated a new educational project, termed [abstract contained text which couldn't be captured], to teach general concepts in computer science by infusing large-scale problems in computer graphics into the undergraduate curriculum. In this paper, we present our approach to teaching a first course in computer science (CS1) using a recently published graphics research problem. The results from our first semester offering are promising, as students, energized by the subject matter and visual output, produced excellent work and evaluated the class highly.
Nanosecond infrared absorption spectrometer

In the present publication, we describe the design details of a time-resolved IR absorption spectrometer with a broadband probe capability and nanosecond time resolution. The IR probe source is based on stimulated electronic Raman scattering in a metal vapor and has a measured pulsewidth of ~1 ns. Broadband collection of the IR light is facilitated by the unique use of a multielement detector array with its associated signal collection circuitry. The spectrometer has been used to record the IR spectra of some gas phase radicals which are indicative of its applicability to spectroscopic and kinetic investigations of short-lived molecular species.
Monolayer Solids of Short Alkanes and Perfluoroalkanes

Potential energy calculations are used to discuss the relative stability of monolayer solid latices on graphite for C2H6, C3H8, C2F6, and C3F8. Triangular, centered-rectangular, and herringbone lat...
Validity of therapist self-report ratings of fidelity to evidence-based practices for adolescent behavior problems: correspondence between therapists and observers.

Developing therapist-report fidelity tools to support quality delivery of evidence-based practices in usual care is a top priority for implementation science. This study tested the reliability and accuracy of two groups of community therapists who reported on their use of family therapy (FT) and motivational interviewing/cognitive-behavioral therapy (MI/CBT) interventions during routine treatment of inner-city adolescents with conduct and substance use problems. Study cases (n = 45) were randomized into two conditions: (a) Routine Family Therapy (RFT), consisting of a single site that featured family therapy as its standard of care for behavioral treatment; or (b) Treatment As Usual (TAU), consisting of five sites that featured non-family approaches. Therapists and trained observational raters provided FT and MI/CBT adherence ratings on 157 sessions (104 RFT, 53 TAU). Overall therapist reliability was adequate for averaged FT ratings (ICC = .66) but almost non-existent for MI/CBT (ICC = .06); moreover, both RFT and TAU therapists were more reliable in reporting on FT than on MI/CBT. Both groups of therapists overestimated the extent to which they implemented FT and MI/CBT interventions. Results offer support for the feasibility of using existing therapist-report methods to anchor quality assurance procedures for FT interventions in real-world settings, though not for MI/CBT.
Hierarchy helps it work that way

Jerry Fodor argues, in The mind doesn't work that way (Cambridge, MA: MIT Press, 2000, that the computational theory of mind is undermined by the pervasive context sensitivity of human cognition. His objections can be easily met, however, by noting the properties of appropriately structured representation hierarchies.
New assessment systems for residential treatment, management, research, and evaluation: A symposium

An introduction and overview are presented to new observational assessment systems for ongoing assessment and monitoring of both staff and resident (client or patient) functioning in residential treatment programs for emotionally disturbed and mentally retarded adults.
Effects of 2-(2,4-dimethylphenyl)indan-1,3-dione on serum lipoprotein and lipid metabolism of rodents.

2-(2,4-Dimethylphenyl)indan-1,3-dione was shown to be a potent hypolipidemic agent in rodents, lowering significantly both serum cholesterol and triglyceride levels at 20 mg/kg/day. The agent in vivo inhibited the enzymatic activities of ATP-dependent citrate lyase, acetyl-CoA synthetase, cholesterol-7α-hydroxylase, acyl-CoA cholesterol acyl transferase,sn-glycerol-3-phosphate acyl transferase and phosphatidylate phosphohydrolase. Tissue lipid levels of liver and small intestine also were reduced by the agent. The rat serum lipoprotein lipid content was modulated by the drug, which should be favorable for the removable of cholesterol from peripheral tissue for conduction to the liver for clearance from the body. Low density lipoprotein (LDL) cholesterol levels were reduced after treatment, which suggests that the agent potentially reduces deposition of cholesterol in plaques. If chemotherapy for atherosclerosis is to be successful, then the high density lipoprotein (HDL) cholesterol level needs to be elevated more than 16% to 25%, the level produced by current hypolipidemic agents. 2-(2,4-Dimethylphenyl)-indan-1,3-dione offers a 75% increase in HDL cholesterol levels and a 30% reduction of LDL cholesterol levels with a suppression of de novo synthesis of lipids and a reduction of tissue cholesterol deposition.
Effects of oral hydralazine on rest and exercise hemodynamics in patients with aortic or mitral regurgitation and left ventricular dysfunction

Summary: The hemodynamic effects of afterload reduction were studied at rest and during two levels of upright exercise in patients with aortic or mitral regurgitation and left ventricular dysfunction. Eleven patients underwent invasive hemodynamic monitoring before and after 50-70 mg of oral hydralazine was given every 6 h for 48 h. At rest, heart rate and mean arterial pressure after hydralazine were unchanged from control. During exercise, there was no significant change in heart rate, but mean arterial pressure fell significantly during the first level of exercise. Systemic vascular resistance was elevated before hydralazine and was significantly reduced after treatment at both exercise levels. After hydralazine, the resting oxygen consumption was significantly elevated at rest but was unchanged during exercise, the arteriovenous oxygen difference was significantly narrowed at both rest and exercise, and the pulmonary capillary wedge pressure was also significantly lower at both rest and exercise. In this select group of patients who are not candidates for surgical valve replacement, chronic afterload reduction with oral hydralazine may result in increased cardiac performance, decreased pulmonary congestion, reduced myocardial oxygen demands, and improvement in resting and/or exertional symptoms.
Use of Continuous Glucose Monitoring Systems in Children with Type 1 Diabetes

Continuous glucose monitoring systems (CGMS) offer a recent technological solution to fear of hypoglycemia and reduction in hyperglycemia. With glucose readings every 5 minutes, and the alarm capabilities to signal rapid increases or decreases in blood glucose, they afford a sense of security for both children and parents. Although children and parents must continue to be vigilant in the treatment of diabetes, CGMS may effectively allow tight diabetes control with earlier detection of hypoglycemia onset. This article provides an overview of CGMS available at the time of publication; new generations of systems have been introduced annually with improvements in sensitivity and user friendliness.
Lysosomal involvement in cellular turnover of plasma membrane sphingomyelin.

Abstract At least two isoenzymes of sphingomyelinase (sphingomyelin cholinephosphohydrolase, EC 3.1.4.12), including lysosomal acid sphingomyelinase and nonlysosomal magnesium-dependent neutral sphingomyelinase, catalyse the degradation of sphingomyelin in cultured human skin fibroblasts. A genetically determined disorder of sphingomyelin metabolism, type A Niemann-Pick disease, is characterized by a deficiency of lysosomal acid sphingomyelinase. To investigate the involvement of lysosomes in the degradation of cellular membrane sphingomyelin, we have undertaken studies to compare the turnover of plasma membrane sphingomyelin in fibroblasts from a patient with type A Niemann-Pick disease, which completely lack acid sphingomyelinase activity but retain nonlysosomal neutral sphingomyelinase activity, with turnover in fibroblasts from normal individuals. Plasma membrane sphingomyelin was labeled by incubating cells at low temperature with phosphatidylcholine vesicles containing radioactive sphingomyelin. A fluorescent analog of sphingomyelin, N-4-nitrobenzo-2-oxa-1,3-diazoleaminocaproyl sphingosylphosphorylcholine (NBD-sphingomyelin) is seen to be readily transferred at low temperature from phosphatidylcholine liposomes to the plasma membranes of cultured human fibroblasts. Moreover, when kinetic studies were done in parallel, a constant ratio of [14C]oleoylsphingosylphosphorylcholine ([14C]sphingomyelin) to NBD-sphingomyelin was taken up at low temperature by the fibroblast cells, suggesting that [14C]sphingomyelin undergoes a similar transfer. The comparison of sphingomyelin turnover at 37°C in normal fibroblasts compared to Niemann-Pick diseased fibroblasts shows that a rapid turnover of plasma membrane-associated sphingomyelin within the first 30 min appears to be similar in both normal and Niemann-Pick diseased cells. This rapid turnover appears to be primarily due to rapid removal of the [14C]sphingomyelin from the cell surface into the incubation medium. During long-term incubation, an increase in the formation of [14C]ceramide correlating with the degradation of [14C]sphingomyelin is observed in normal fibroblasts. In contrast, the level of [14C]ceramide remains constant in Niemann-Pick diseased cells, which correlates with a higher level of intact [14C]sphingomyelin remaining in these cells compared to normal cells. These results are consistent with the interpretation that, in the course of normal cellular metabolism of plasma membrane-associated sphingomyelin, a major fraction of this sphingomyelin is transferred into and subsequently hydrolyzed in lysosomes by lysosomal sphingomyelinase, while the remaining minor fraction may be degraded in other subcellular compartments by nonlysosomal neutral sphingomyelinase.
Serine metabolism in human pregnancy.

Serine plays an important role in intermediary metabolism as a source of one carbon pool for nucleotide biosynthesis, as a precursor for glycine and glucose, and as a contributor to cysteine biosyn...
Performance Analysis of Random Vector Quantization Limited Feedback Beamforming

Beamforming is a simple technique for guarding against the negative effects of fading in a multiple antenna wireless systems. Unfortunately this technique requires the transmitter to have knowledge of the forward-link channel, which is often not available a priori. One solution is to design the beamforming vector using a limited number of feedback bits sent from the receiver to the transmitter. In limited feedback beamforming, every beamforming vector lies in a codebook known to both the transmitter and receiver. Random vector quantization (RVQ) is a simple approach to codebook design that generates the vectors independently from a uniform distribution on the complex unit sphere. This paper derives important performance metrics for a multiple-input single-output (MISO) RVQ system employing limited feedback beamforming
Can Management by Outcome Invigorate Substance Abuse Treatment?: Microincentives and the Quality of Care

Given the rapid changes in health care, the economic consequences of substance abuse and the contemporary problems of substance abuse treatment must be acknowledged and addressed. These problems include poor treatment outcomes, difficulty of recruiting and retaining treatment staff, and failure of treatment programs to adopt effective research innovations. The authors suggest that these problems result from the incentives of the current payment system. To correct this, they propose an outcome-based incentive system to improve treatment outcome. This system is designed to enhance both treatment- and cost-effectiveness while being flexible and sensitive to local community circumstances.
Cellular Plasticity within the Pancreas— Lessons Learned from Development

The pancreas has been the subject of intense research due to the debilitating diseases that result from its dysfunction. In this review, we summarize current understanding of the critical tissue interactions and intracellular regulatory events that take place during formation of the pancreas from a small cluster of cells in the foregut domain of the mouse embryo. Importantly, an understanding of principles that govern the development of this organ has equipped us with the means to manipulate both embryonic and differentiated adult cells in the context of regenerative medicine. The emerging area of lineage modulation within the adult pancreas is of particular interest, and this review summarizes recent findings that exemplify how lessons learned from development are being applied to reveal the potential of fully differentiated cells to change fate.
Management of Fetal Lung Lesions

Prenatal diagnosis provides insight into the in utero evolution of fetal thoracic lesions such as congenital cystic adenomatoid malformation (CCAM), bronchopulmonary sequestration (BPS), congenital lobar emphysema, and mediastinal teratoma. Serial sonographic study of fetuses with thoracic lesions has helped define the natural history of these lesions, determine the pathophysiologic features that affect clinical outcome, and formulate management based on prognosis.
Efficient Highly-Parallel Decoder Architecture for Quasi-Cyclic Low-Density Parity-Check Codes

In this paper, the authors propose an efficient highly-parallel decoder architecture using partially overlapped decoding scheme for quasi-cyclic (QC) low-density parity-check (LDPC) codes, which leads to reduction in hardware complexity and power consumption. Generally, due to the regularly structured parity-check matrix H of QC LDPC codes, the message updating computations in the check node unit (CNU) and the variable node unit (VNU) can be efficiently overlapped, which increases the decoding throughput by maximizing the hardware utilization efficiency (HUE). However, the partially overlapped decoding scheme cannot be used to design a highly-parallel decoding architecture for high-throughput applications. For (3, 5)-regular QC LDPC codes, our proposed method could reduce the hardware complexity by approximately 33% for the CNU and 20% for the VNU in the highly-parallel decoder architecture without any performance degradation. In addition, the power consumption can be minimized by reducing the total number of memory accesses for updated messages.
Copper spectra in a laser-generated plasma: measurements and classifications of Cu XII to Cu XXI

A vapor containing 10- to 20-times-ionized copper was generated by focusing a 1-GW, 15-nsec, Nd–glass-laser pulse down to 0.3 mm on a metallic copper sample. Spectral radiation in the range of 125 to 450 A was recorded photographically with the National Bureau of Standards 10.7-m grazing-incidence spectrograph. Ninety-two spectral lines arising from Cu xii to Cu xxi (Ar i through F i isoelectronic sequences) were identified. Twenty-six of these, mainly in Cu xix and Cu xxi, had been interpreted previously. The transition arrays observed were of the type 3s2 3pn–3s2 3pn−13d and −3s3pn+1. Slater integrals were fitted to the energy levels derived from these data and from previously measured magnetic-dipole lines.
A comparison of ligand‐induced redistribution of surface immunoglobulins, alloantigens, and concanavalin A receptors on mouse lymphoid cells

Redistribution of surface immunoglobulins (Ig), H-2b, Thy-1.2 and TL. 1,2,3 alloantigens, and concanavalin A (Con A) receptors on mouse thymus, lymph node and spleen cells into “caps” induced by bivalent antibodies or ligands was compared by immunofluorescence. Surface Ig was capped rapidly following attachment of anti-Ig antibody at 37°. Capping of alloantigens and Con A receptors occurred very slowly following attachment of alloantibody or Con A, but much more rapidly after addition of a secondary bivalent antibody. An inverse relationship between the number of surface component sites per cell and the extent of capping of that component was observed. Capping of alloantigens sparsely represented on the cell surface was not inhibited by high concentrations of alloantibody, in contrast to capping of alloantigens present in greater quantities. These results suggest that factors in addition to molecular cross-linking may be involved in ligand-induced redistribution of cell surface components.
Nonparametric Random Variate Generation Using a Piecewise-Linear Cumulative Distribution Function

The standard approach to solving the interpolation problem for a trace-driven simulation involving a continuous random variable is to construct a piecewise-linear cdf that fills in the gaps between the data values. Some probabilistic properties of this estimator are derived, and three extensions to the standard approach (matching moments, weighted values, and right-censored data) are presented, along with associated random variate generation algorithms. The algorithm is a nonparametric blackbox variate generator requiring only observed data from the user.
Layout-driven test generation

Conventionally, test vectors are generated using gate-level models to represent the circuit design and abstract fault models (e.g. the stuck-fault model) to describe all of the processing defects causing circuit failure. The authors demonstrate that test vectors can be generated using realistic defect models and actual IC layouts, which should lead to test vectors with a higher defect detectability. The layout-driven generation of the faults has a computational complexity which is similar to that of design-rule checking, i.e. O(n log n). >
Nonlinear Atmospheric Adjustment to Momentum Forcing

A nonlinear, numerical model of a dry, compressible atmosphere is used to simulate the hydrostatic and geostrophic adjustment to a localized prescribed injection of momentum applied over 5 min. with a size characteristic of an isolated, deep, cumulus cloud. This theoretical study is relevant to the initialization of updrafts in compressible numerical weather prediction models. The four different forcings studied are vertical, divergent horizontal, and nondivergent horizontal momentum forcings, and a prescribed transverse circulation. These forcings are applied to an isothermal atmosphere, a nonisothermal atmosphere, and an atmosphere with a nonisothermal troposphere capped by an isothermal stratosphere. These scenarios are studied by analyzing the resulting perturbation fields and the energetics of the system. Potential vorticity is used to determine the possibility of steady atmospheric states. The energetics of the system are examined to observe the creation and propagation of atmospheric waves. Both traditional and available energetics are used to determine the presence and strength of these waves. Traditional energetics consist of kinetic, internal, and potential energies while available energetics consist of kinetic, available potential, and available elastic energies. The efficiencies are similar for these different energetics, though they represent different phenomena. The traditional energetics show a strong dependence on the presence of a Lamb wave, whereas in the available energetics the Lamb wave has little or no effect.
Significance of Endophyte Toxicosis and Current Practices in Dealing with the Problem in the United States

Major breakthroughs in agricultural research occur relatively infrequently. Even when they do occur it can take many years for the new knowledge, which is often narrow in application and/or difficult to implement, to have much effect on farms. Discoveries which involve multiple disciplines and which rapidly and heavily impact on numerous areas of agricultural production are particularly rare.
DETERMINATION OF SOME MERCURIALS VIA ACETOLYSIS AND NONAQUEOUS ACIDIMETRIC TITRATION.

An analytical method for certain mercurials is based upon their solvolysis in acetic acid to yield either mercuric acetate or a monosubstituted mercuric acetate. When an excess of methylamine hydrochloride is added, an amount of strong base is released which is equivalent to the mercury-bound acetate. The solution is titrated with standard acetous perchloric acid to complete the analysis. The method is applicable to many mercurials containing a mercury-nitrogen, mercury-oxygen, or mercury-sulfur bond.
Associations of stream health to altered flow and water temperature in the Sierra Nevada, California

Alteration of streamflow and thermal conditions may adversely affect lotic invertebrate communities, but few studies have assessed these phenomena using indicators that control for the potentially confounding influence of natural variability. We designed a study to assess how flow and thermal alteration influence stream health—as indicated by the condition of invertebrate communities. We studied thirty streams in the Sierra Nevada, California that span a wide range of hydrologic modification due to storage reservoirs and hydroelectric diversions. Daily water temperature and streamflows were monitored, and basic chemistry and habitat conditions were characterized when invertebrate communities were sampled. Streamflow alteration, thermal alteration, and invertebrate condition were quantified by predicting site-specific natural expectations using statistical models developed using data from regional reference sites. Monthly flows were typically depleted (relative to natural expectations) during fall, winter, and spring. Most hydrologically altered sites experienced cooled thermal conditions in summer, with mean daily temperatures as much 12 °C below natural expectations. The most influential predictor of invertebrate community condition was the degree of alteration of March flows, which suggests there are key interactions between hydrological and biological processes during this month in Sierra Nevada streams. Thermal alteration was also an important predictor—particularly at sites with the most severe hydrological alteration. This article is protected by copyright. All rights reserved.
The effects of gamma radiation on the properties of composite restorative resins.

Abstract The effects of gamma radiation at therapeutic dosage levels on the physical properties of three anterior (two light-cured and one autocure) composites and a light cured posterior composite were studied. Gamma radiation had no effect on the autocured composite but had varied effects on the light cured systems. The diametral tensile strength and dimensional stability were unaffected, water sorption and solubility were reduced but surface and bulk hardnesses were increased with the hardness increases linearly related to the radiation dosage. These effects may arise from continued polymerization of the air-inhibited surface layer and possibility of low molecular weight entities within the matrix. Overall, therapeutic levels of gamma radiation had no detrimental effects on the physical properties of the composite resins.
Process Measures for Psychodynamic Psychotherapy

Research focusing on psychodynamic psychotherapy has grown considerably in the past three decades [1]. Recently, there has been growing interest in studying the process of psychotherapy. The present chapter provides a brief review of some measures that are useful for research into psychodynamic psychotherapy. We review ten measures designed to assess the process occurring in psychotherapy. For each measure, we provide a general description of the measure’s purpose, scales, and methods, and provide some examples of how the measure has been used by researchers in the past. This chapter is not intended to be comprehensive. Instead, we provide a sample of several different types of measures and measurement methods, all of which are likely to be of interest to investigators who wish to empirically study psychodynamic psychotherapy.
Mitochondrial Quality Control as a Therapeutic Target

In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell growth, and cell death. They participate in cell communication and regulation of inflammation and are important considerations in aging, drug toxicity, and pathogenesis. The cell's capacity to maintain its mitochondria involves intramitochondrial processes, such as heme and protein turnover, and those involving entire organelles, such as fusion, fission, selective mitochondrial macroautophagy (mitophagy), and mitochondrial biogenesis. The integration of these processes exemplifies mitochondrial quality control (QC), which is also important in cellular disorders ranging from primary mitochondrial genetic diseases to those that involve mitochondria secondarily, such as neurodegenerative, cardiovascular, inflammatory, and metabolic syndromes. Consequently, mitochondrial biology represents a potentially useful, but relatively unexploited area of therapeutic innovation. In patients with genetic OXPHOS disorders, the largest group of inborn errors of metabolism, effective therapies, apart from symptomatic and nutritional measures, are largely lacking. Moreover, the genetic and biochemical heterogeneity of these states is remarkably similar to those of certain acquired diseases characterized by metabolic and oxidative stress and displaying wide variability. This biologic variability reflects cell-specific and repair processes that complicate rational pharmacological approaches to both primary and secondary mitochondrial disorders. However, emerging concepts of mitochondrial turnover and dynamics along with new mitochondrial disease models are providing opportunities to develop and evaluate mitochondrial QC-based therapies. The goals of such therapies extend beyond amelioration of energy insufficiency and tissue loss and entail cell repair, cell replacement, and the prevention of fibrosis. This review summarizes current concepts of mitochondria as disease elements and outlines novel strategies to address mitochondrial dysfunction through the stimulation of mitochondrial biogenesis and quality control.
Nephrolithiasis and Risk of Incident Bone Fracture

Purpose: Higher urine calcium is a common feature of calcium nephrolithiasis and may be associated with lower bone mineral density in individuals with kidney stones. However previous population based studies of kidney stones and the risk of bone fracture demonstrate conflicting results. We examined independent associations between a history of kidney stones and incident fracture.Materials and Methods: We performed prospective studies using data from the Nurses' Health Study of 107,001 women with 32 years of followup and the Health Professionals Follow-up Study of 50,982 men with 26 years of followup. We excluded premenopausal women, men younger than 45 years and individuals who reported osteoporosis at baseline. Study outcomes were incident wrist (distal radius) or incident hip (proximal femur) fracture due to low or moderate trauma. Cox proportional hazards regression was used to adjust for multiple factors, including age, race, body mass index, thiazide use, supplemental calcium and dietary intakes.Resu...
Capital Budgeting and Managerial Retention under Product Market Competition

This paper studies how division managers' access to venture capital (VC) markets affects the internal capital allocation decision of a multi-division firm. Division managers may leave firms and seek venture financing if their project ideas are not funded by headquarters. A successful new venture poses a threat to the revenue of the incumbent firm through product market competition. The paper characterizes headquarters' decision to retain managers and allocate capital for different degrees of product market competition and fundamental parameters in the VC markets. The paper shows that distortions in internal capital allocations arise as headquarters retains managers by allocating more capital to their divisions and increasing compensation. These distortions may lead to under-investment or over-investment in high NPV projects as well as creation of new ventures. The paper also shows that improving efficiency in the VC markets may induce incumbent firms to aggressively retain managers by over-investing in their ideas and may not necessarily lead to more VC-backed startups. The incentive to retain managers is higher in more concentrated industries. The paper derives novel empirical implications linking industry characteristics to diversification benefits and investment behavior of multidivisional firms.
“Through the looking glass: envisioning new library technologies” telling stories with technology

Purpose – This column aims to explore the technologies that are enabling libraries, and the communities they serve, to easily tell their own stories. Design/methodology/approach – Point of view. Findings – Libraries can facilitate the acquisition of technology and literacies necessary to make recording, sharing and preserving stories of all kinds easy for library patrons. Practical implications – Libraries collect, preserve and help distribute information to serve their communities. Originality/value – By facilitating access to these emerging mediums, libraries can both empower their communities and play an active role in preserving their communities’ histories.
Big systems and big reliability challenges

Publisher Summary The chapter describes possible approaches for the effective use of multi-teraflop and petaflop systems. The techniques that allow an MPI application to continue execution despite system component failures is presented. One of these techniques is diskless check-pointing, which enables more frequent checkpoints by redundantly saving check-pointed data in memory. Another technique uses low-cost mechanisms to capture data for failure prediction, which enables creation of dynamic schemes for improved application resilience. The data to quantify the reliability of large systems is discussed in the chapter. This is followed by a description of fault injection techniques .The fault-tolerance for MPI applications and system monitoring issues is discussed in detail. The chapter explains how to use such techniques for adaptive control. Several research efforts have addressed the fault-tolerance limitations in MPI. These research efforts include Los Alamos MPI (LA-MPI), which provides end-to-end network fault tolerance, compile-time and runtime approaches that redirect MPI calls through a fault-tolerance library based on compile-time analysis of application source code, and message logging and replay techniques.
Abstract 4277: TRAF2 is a key mediator of the EGF-induced signaling pathway.

TRAF2 plays a critical role in the mediation of the TNF-R signaling pathway toward activation of NF-κB and JNKs. Here, we reveal a novel function of TRAF2 in the epidermal growth factor (EGF) signaling pathway. Knockdown of TRAF2 blocked EGF-induced AP-1 activity and anchorage-independent cell transformation. We also showed that TRAF2 is required for RSK2 activity through RSK2 ubiquitination and that RSK2 plays a critical role in AP-1 activity mediated through CREB/c-Fos, which regulate anchorage-independent cell transformation. Citation Format: Cong Peng, Feng Zhu, Weihong Wen, Ke Yao, Weiya Ma, Ann Bode, Zigang Dong. TRAF2 is a key mediator of the EGF-induced signaling pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4277. doi:10.1158/1538-7445.AM2013-4277
Teaching for Conversion: Faith, Doubt, and Gerard Manley Hopkins in the Evangelical Academy

Following much recent scholarship on the relationship between the affective and cognitive dimensions of the human person, and the ways in which that relationship shapes the educational process, this article argues that conversion should be a primary goal of the humanist educator, whether that conversion be religious or theological in nature (as it might be in an explicitly religious institution) or a more generic idea of the educator cultivating a student’s love for a particular author, poem, or other imaginative literary work. The context for this argument is the author’s own experience teaching a poetry course in “faith and doubt” at an evangelical university, and the article focuses on the British Jesuit Gerard Manley Hopkins.
Application of GPRS Communication on Water-dispacthing Scheduling Automation System

This thesis put forward GPRS communication method to realize the close-knit links between water-dispatching system sub-centers and the central station basing on communication features of small hydropower water-dispatching scheduling automation system,and meanwhile gave emphasis to the application of GPRS communication from the technical program,operating costs and other aspects of running the actual results.The paper also raised in the practical application problems that need attention.
Cryopreservation of human induced pluripotent stem cells(iPS cells) through vitrification in mini straw

Objective:To explore the method of cryopreservating human induced pluripotent.Methods:Colonies of induced pluripotent stem cells(iPS cells) were dissected into pieces(containing approximately 100～200 cells) using mechanical methods,then sequentially treated with 10%,20% vitrification solution,and sealed in mini straws with the second solution.Mini straws were then dropped into liquid nitrogen immediately for vitrification and cryopreservation.After vitrificated preservation,iPS cells were thawed in 37℃ water bath,and were immediately balanced in 0.2 mol/L sucrose solution and then in 0.1 mol/L sucrose solution,and at last plated on feeder layer cells.Alkaline phosphatase activity,expressions of OCT4,SOX2 in iPS cells and cell differentiation were evaluated.Results:Post vitrification and thawing,iPS cells maintain properties of pluripotent stem cells,including normal morphology,alkaline phosphatase staining,OCT4 and SOX2 expression.Calculation of colony recovery rates indicates that approximate(77.40±13.12)% of iPS cell colonies survived the freezing and thaw procedures.Conclusion:Vitrification with ministraws is a very useful and effective cryopreservation method for iPS cells.
Content analysis of four heavy metals in coix seed by graphite furnace atom absorbance spectrometry

The contents of lead,copper,cadmium and nickel in coix seed were determined through graphite furnace atomic absorption spectrometry by digesting coix seed with wet method.The results show that the contents of lead,copper,cadmium and nickel were 2.81 mg/kg,0.17 mg/kg,15.93 mg/kg,1.69 mg/kg respectively.The recoveries were between 97% and 102% by standard addition method and RSD was less than 2.5%.Therefore the method for determining the heavy metals in coix seed is rapid and accurate.
Developing a suicide precaution procedure.

The process of creating a procedure that meets National Patient Safety Goal 15 is described. These tools help staff provide safe and consistent care to adult patients who are suicidal in the acute inpatient medical setting at an academic medical center in the southwest United States.
Significance of Bacteriuria with Presumed Nonpathogenic Organisms

AbstractThe results of 2,793 clean catch midstream specimens submitted to the microbiology laboratory were examined to determine if the isolation of reputed non-pathogens such as Lactobacillus, Staphylococcus epidermidis, Micrococcus and diphtheroids represented poor collection technique, contaminant growth by failure to plate or refrigerate quickly or actual urinary tract infection. Eight per cent of the inpatient cultures and 18 per cent of the outpatient cultures had more than 105 colony-forming units per ml. of these non-pathogens. Of the outpatient cultures with more than 105 colony-forming units per ml. of non-pathogens 44 per cent had symptoms of urinary tract infection and more than 10 white blood cells per high power field in the urinary sediment, compared to 3 per cent of inpatients. In a prospective analysis of an outpatient population a second clean catch midstream specimen was collected within 2 hours of the first specimen with careful attention to sterile collection technique. Of 15 cases of...
Ein Vorschlag zur gemeinsamen Genese von Hörverlust, Rekruitment und Ohrgeräuschen bei akuten Innenohrveränderungen

Pathological changes on the stereocilia of cochlear hair cells observed by Bredberg et al. (1972) after noise exposure and in the early stages of antibiotic intoxication are suggested to cause a mechanical decoupling between the tectorial membrane and the hair cells. During acute episodes of endolymphatic hydrops a similar decoupling is suggested to occur, although for different reasons. Harris (1968) calculated the noise generated at the input to the hair cells on account of the Brownian motion of air particles in front of the tympanic membrane. For tight coupling, he obtained a level of (−)22 dB re auditory threshold. For loose coupling this noise was found to increase to +33 dB, i.e., for 55 dB. These two independent findings are used to account for the combination of hearing loss, recruitment, and tinnitus observed with the inner-ear pathologies mentioned. The proposed hypothesis is in good agreement with clinical observations.
Fournier's gangrene: a complication of penile prosthetic implantation in a renal transplant patient

AbstractThe management of erectile impotence in renal transplant patients remains problematical. The enhanced risk of surgical infection in this immunosuppressed patient population must be addressed if prosthetic implantation is contemplated. A case of Fournier’s gangrene (synergistic necrotizing gangrene of the genitalia) following implantation of a Small-Carrion penile prosthesis Is reported. This potentially life-threatening infection demonstrates graphically the surgical infection risk of this population and suggests extreme caution before proceeding with a prosthetic operation in this unique subset of Impotent patients.
HORNER SYNDROME AFTER PERCUTANEOUS ETHANOL INJECTION FOR TREATMENT OF METASTATIC PAPILLARY THYROID CARCINOMA: CASE REPORT AND REVIEW OF THE LITERATURE

ABSTRACT Objective: One option to treat locoregional recurrence of thyroid carcinoma is with percutaneous ethanol injection (PEI). Although complications with this treatment are rare, we describe a patient who developed Horner syndrome after PEI. In addition, we reviewed the literature on complications after PEI for thyroid disease. Methods: A clinical case report was performed on a patient who underwent PEI and subsequently developed ptosis, miosis, and anhidrosis. Based on these classic findings, she was diagnosed with Horner syndrome. A Medline search was performed to identify all complications after PEI for thyroid disease. Results: A 31-year-old woman with stage 1 papillary thyroid carcinoma (PTC) metastatic to the cervical lymph nodes was treated by total thyroidectomy and central lymph node dissection followed by radioactive iodine. The disease recurred in a single lymph node in the right neck, and she opted for PEI treatment. Postprocedurally, the patient developed right-sided miosis, ptosis, and ...
LDL Receptors and HDL

Overview • Although most all nucleated mammalian cells contain LDL receptors, hepatocytes generally retain the highest concentration.
1996: The Adam Smith Address an Ambitious Agenda for Economic Growth

In this presidential election year, it has become fashionable to advocate faster economic growth as the elixir to cure all that ails the American society. Surely an average annual growth rate in the neighborhood of 2 percent is anemic, whether we view it in historical terms or by the current standards of the economies of China and Southeast Asia. Faster growth produces all sorts of good things, such as lower budget deficits, more new jobs, higher incomes, and rising living standards. Thus, who can object to the general idea of achieving larger economic output?
The Terminal Phase

The beginning of the terminal phase is signaled by actions of the members aimed at identification with the therapist. The two great processes up to this time, i.e., limiting the significance of the therapist and strengthening the competence and identity of the members, lead naturally into the identification interactions. The concern with social rule, with standards and values, and with identity ultimately will focus on the therapist. What kind of person is the therapist? What does he believe? Am I like him? These are the basic questions. To offer leadership in the exploration of these questions is the major function of the therapist during the terminal phase.
Determining the number of simulation runs: Treating simulations as theories by not sampling their behavior

How many times should a simulation be run to generate valid predictions? With a deterministic simulation, the answer simply is just once. With a stochastic simulation, the answer is more complex. Different researchers have proposed and used different heuristics. A review of the models presented at a conference on cognitive modeling illustrates the range of solutions and problems in this area. We present the argument that because the simulation is a theory, not data, it should not so much be sampled but run enough times to provide stable predictions of performance and the variance of performance. This applies to both pure simulations as well as human-in-the-loop simulations. We demonstrate the importance of running the simulation until it has stable performance as defined by the effect size of interest. When runs are expensive we suggest a minimum number of runs based on power calculations; when runs are inexpensive we suggest a maximum necessary number of runs. We also suggest how to adjust the number of runs for different effect sizes of interest.
A High-Frequency AC-Link Single-Stage Asymmetrical Multilevel Converter for Grid Integration of Renewable Energy Systems

Different power electronic converter topologies have been investigated to integrate renewable energy systems to the grid. Cascaded multilevel converters with a high-frequency link have emerged as a viable candidate for such applications. Electrical isolation can be provided using a compact high-frequency transformer connected in the link thus avoiding a bulky line frequency transformer. The use of cascaded modules allows the generation of a multilevel voltage having low total harmonic distortion but increases the overall system size. In this paper, a 15-level high-frequency ac-link single-stage asymmetrical multilevel converter for grid integration is proposed. The single-stage conversion approach eliminates the dc-link capacitors, resulting in a reduced footprint. The asymmetrical module voltages are generated by the multiwinding transformer having unequal turns on each of the secondaries. This allows the generation of 15 output voltage levels, using only three modules in each phase. A modulation strategy is proposed to generate multilevel output voltage. The effect of switch nonidealities on the output voltage is analyzed and two compensation techniques are developed to improve the voltage profile. A multiwinding high-frequency transformer is designed and characterized for the proposed converter. The presented concepts are verified by simulation and further validated experimentally on a three-phase 15-level converter prototype.
HEPATIC SYNTHESIS OF EXPORT PROTEINS

Publisher Summary This chapter focuses on hepatic synthesis of export proteins. In the case of albumin, there is evidence that the hepatocyte is the site of synthesis of most of the ferritin in the liver. The site of synthesis of ferritin was at first identified as being preferentially on free liver ribosomes. However, the data of Redman, Puro, and Richter showed an excess of ferritin synthesis by the rough endoplasmic reticulum that was greater than anticipated from cross-contamination of fractions. In general, membrane-bound ribosomes have been identified as the main or exclusive site of synthesis of secreted proteins, while proteins retained in the liver cells are made on free ribosomes. The increased number of polysomes making albumin in the livers of the nephrotic animals is because of an increase in albumin mRNA, and not to changes in the rate of translation. Thus, albumin synthesis is selectively increased in nephrosis.
Protein Kinase C Isoform ε Negatively Regulates ADP-Induced Thromboxane Generation by Regulating cPLA2 Activation and Calcium Mobilization In Platelets

Abstract Abstract 2020 Positive regulatory role of Protein Kinase C (PKC) isoforms in platelets have been extensively studied. However, negative regulatory roles of PKCs in platelets are poorly understood. In this study we investigated the mechanism by which PKCs negatively regulate ADP-induced thromboxane generation and identified PKC isoforms involved in this process. Pan PKC inhibition with GF109203X potentiated ADP-induced cPLA2 phosphorylation suggesting that PKCs negatively regulate thromboxane generation by regulating cPLA2 activation. Inhibition of PKCs potentiated ADP-induced ERK activation and intracellular calcium mobilization, two upstream signaling molecules of cPLA2.These data suggest that PKCs negatively regulate thromboxane by regulating ERK activation and calcium mobilization, which inturn regulate cPLA2 activation. Pan-PKC inhibition potentiated ADP-induced, P2Y1 receptor-mediated calcium mobilization in platelets independent of P2Y12-receptor. Pretreatment of platelets with GF109203X, a Pan PKC inhibitor, but not Go-6976, a classical PKC isoform inhibitor, potentiated ADP-induced thromboxane generation. Thus, we investigated the role of various novel class of PKC isoforms (nPKCs) in platelets. We have previously demonstrated that nPKC η, θ, δ positively regulates agonist-induced thromboxane generation in platelets. Thus, we investigated if the role of nPKC e in ADP-induced thromboxane generation using PKC e knockout mice (PKCe KO). ADP-induced thromboxane generation in PKC e KO murine platelets was ten-fold higher than that of wild type platelets. Furthermore, PKC e KO mice exhibited shorter times to occlusion in FeCl3-induced arterial injury model and shorter bleeding times in Tail bleeding experiments. We conclude that PKCe negatively regulates ADP-induced thromboxane generation in platelets and thereby offers protection against thrombosis. Disclosures: No relevant conflicts of interest to declare.
Measuring Surgical Quality

Improving surgical care requires an in depth understanding of how to measure quality. We are currently witnessing an unprecedented level of investment from payers, policy makers, patient advocacy groups and professional societies to measure the quality of care surgeons provide. Despite the widespread interest in measuring quality, there is little consensus how it should be done. Payers and regulators often target processes of care (e.g. appropriate use of preoperative antibiotics), while surgeons tend to focus on outcomes that are seen as the “bottom line” (e.g. 30-day post-operative mortality rates.) Most recently, numerous stakeholders are advocating for the use of patient reported information (e.g. “How did this operation affect your daily living?”)
The relationship between dynamic and pseudo-thermodynamic measures of the glass transition temperature in nanostructured materials.

Despite decades of research on the effects of nanoconfinement on the glass transition temperature Tg, apparent discrepancies between pseudothermodynamic and dynamic measurements of these effects have raised questions regarding the presence of long-ranged interfacial dynamic gradients in glass-forming liquids. Here we show that these differences can be accounted for based on disparities in these methods’ weightings over local Tg’s within an interfacial gradient. This finding suggests that a majority of experimental data are consistent with a broad interfacial dynamic interphase in glass-forming liquids.