cssi/SciSciGPT-SciSciNet huggingface dataset:
The production of practice theories

This comparative case study explores the impact of four influential practitioner-generated theories from the 1970s to the present in the separate domains of finance, military strategy, nursing, and theology, and it discusses why bibliometric research tends to overlook such “invisible” theories from practice, despite their increasing importance in many areas. The concept of the “practice field” as a site for not only the reception of theories into practice but also the production of practice theories themselves may prove useful. © 2011 Wiley Periodicals, Inc.
Agenda dissonance: immigrant Hispanic women's and providers' assumptions and expectations for menopause healthcare.

This focus group study examined immigrant Hispanic women’s and providers’ assumptions about and expectations of healthcare encounters in the context of menopause. Four groups of immigrant women fro...
Proficiency Testing Matters

Far too many laboratories consider proficiency testing just a necessary evil, little more than periodic pass–fail exercises we perform solely to meet regulatory requirements. In addition, too many of us belittle point-of-care (POC)2 testing as a passing fad, a technology so inferior to what we use in our own laboratories that it hardly warrants our attention. Clearly, a report that combines these 2 topics, such as the one in this issue of Clinical Chemistry (1), runs the risk of commanding little attention. That would be a very unfortunate mistake, because it has important lessons for all of us who practice laboratory medicine in our efforts to improve patient care. As Stavelin et al. (1) suggest, POC testing represents an important and growing segment of laboratory medicine. Many important clinical decisions are based on these technologies. Even if the CVs of POC testing, and indeed their accuracies, are not as good as central-laboratory techniques, POC testing modalities can sometimes have a more positive impact on certain aspects of healthcare. A POC creatinine test that predicts a patient's risk for contrast-induced nephropathy and is carried out in 10 min in the emergency room prior to radiologic imaging trumps (as long as it is “good enough”) a central-laboratory test that takes 30 min (or longer) to reach the caregivers (2). Even in nonurgent situations, the availability of such POC tests can be extremely valuable in preventing contrast-induced nephropathy (3). Among the more common, and more important, decisions that clinicians make on the basis of laboratory test results are those related to achieving therapeutic international normalized ratios (INRs) in the management of oral anticoagulants (specifically, vitamin K antagonists such as warfarin). In general, data indicate that POC devices can perform reasonably well analytically (4, 5). In addition, the use of POC …
The Arithmetic-Geometric Mean of Gauss

The arithmetic-geometric mean of two numbers a and b is defined to be the common limit of the two sequences , and , determined by the algorithm (0.1) . Note that a 1 and b 1 are the respective arithmetic and geometric means of a and b, a 2 and b 2 the corresponding means of a 1 and b 1, etc. Thus the limit (0.2) really does deserve to be called the arithmetic-geometric mean of a and b. This algorithm first appeared in a paper of Lagrange, but it was Gauss who really discovered the amazing depth of this subject. Unfortunately, Gauss published little on the agM (his abbreviation for the arithmetic-geometric mean) during his lifetime. It was only with the publication of his collected works [12] between 1868 and 1927 that the full extent of his work became apparent. Immediately after the last volume appeared, several papers (see [15] and [35]) were written to bring this material to a wider mathematical audience. Since then, little has been done, and only the more elementary properties of the agM are widely known today.
Innovation in medicine: Ignaz the reviled and Egas the regaled.

In our current climate of rapid technological progress, it seems counterintuitive to think that modern science can learn anything of ethical value from the dark recesses of the nineteenth century or earlier. However, this happens to be quite true, with plenty of knowledge and wisdom to be gleaned by studying our scientific predecessors. Presently, our journals are flooded with original concepts and potential breakthroughs, a continuous stream of ideas pushing the frontiers of knowledge ever forward. Some ideas flourish while others flounder; but what sets the two apart? The distinguishing feature between success and failure within this context is the ability to discern the appropriate time to accept an innovation with open arms, versus when to take a more cautious approach. And the primary arbiters for whether an idea will catch on or not are the professional audience. I illustrate this concept by comparing the initial reception of two innovative ideas from Medicine’s past: sterile technique, and prefrontal lobotomy. Sterile technique was first introduced by Dr. Ignaz Semmelweis and was initially ridiculed and rejected, with Semmelweis eventually dying in exile. Conversely, lobotomy was accepted and lauded and its inventor, Dr. Egas Moniz, won the Nobel Prize for his “discovery”. This begs the question: why was a technique with the potential to save millions of lives initially rejected, whereas paradoxically, one that compromised and sometimes destroyed lives, accepted? Here I explore and analyze the potential reasons why, suggest how we can learn from these mistakes of the past and apply new insight to some current ethical dilemmas.
A Comparative Perspective on the Determinants of the Scale and Productivity of Maritime Trade in the Roman Mediterranean

The scale and productivity of maritime trade is a function of environmental conditions, political processes and economic development that determine demand, and more specifically of trading costs. Trading costs are the sum of transportation costs (comprised of the cost of carriage and the cost of risk, most notably predation), transaction costs and financing costs. Comparative evidence from the medieval and early modern periods shows that the cost of predation (caused by war, privateering, piracy, and tolls) and commercial organization (which profoundly affects transaction and financing costs as well as the cost of carriage) have long been the most important determinants of overall trading costs. This suggests that conditions in the Roman period were unusually favorable for maritime trade. Technological innovation, by contrast, was primarily an endogenous function of broader political and economic developments and should not be viewed as a major factor in the expansion of commerce in this period.
Measurements of Turbulent Pressure Under Breaking Waves

The experiments discussed in this paper describe the turbulent fluid pressures in breaking waves. Before actual data measurements could be made, the instruments used were put through various tests to determine their ability to capture accurate data. These tests were both static and dynamic in nature. Following the tests on the pressure measurement system, waves were produced such that they were breaking at the instrument panel. Wave height, subsurface pressure, and three components of velocity were measured at this point. Using MATLAB to produce plots, waves that produce strong turbulence were isolated and their respective pressures, as well as theoretical and measured velocity heads were observed.
Errors and Error Handling: Antecedents and Consequences at Multiple Organizational Levels

Errors and error handling are crucial concepts in organizations. Errors provide opportunities for learning and innovation, but also pose a threat for organizations. Whether the consequences of errors are positive or negative often depends on the way errors are handled: does an organization try to prevent errors from occuring or does an organization manage errors after they occured? The aim of this symposium is to bring together different streams of research that concern the handling of errors in organizations. Moreover, the symposium aims at answering two questions that have been omitted in the literature to far: (1) What is the role of individual level error management strategies? (2) What are antecedents of both organizational and individual error management? "Relationships Among Near-Miss Attitudes, Error Orientations and Safety Climate Among Nurses" Presenter: Kraig L Schell; Angelo State U. Individual Error Management – Antecedents and Its Impact on Performance Presenter: Christoph Seckler; Leuphana ...
Prediction of GHG Emissions from a New Reservoir

Not until the 1990s was the significance of carbon emissions from reservoirs to greenhouse gas (GHG) accumulation in the atmosphere realized. Currently, hydroelectric projects proposed for World Bank funding must estimate their net GHG footprint, which in most cases has been estimated based on field measurements from similar reservoirs. Here we describe the development and application of CE-QUAL-W2 for prediction of future water quality and net GHG emissions from the proposed Amaila reservoir and downstream Kuribrong River in Guyana, South America. Sediment diagenesis was simulated, and the model enhanced to include the decomposition of a submerged tropical forest. The project site is located upstream of Amaila Falls in the remote highlands of the Guiana Shield. The water quality of the upper Kuribrong River exhibits low pH, low alkalinity, and somewhat high organic carbon concentrations, which is very different from reservoirs in the lowlands of French Guiana and Brazil where GHG fluxes have been measured. High CO 2 concentrations in the reservoir were caused primarily by the low pH and high CO 2 concentrations in the river inflows. Much of this CO 2 was emitted to the atmosphere within the reservoir, and most of the rest was passed through the dam. Net CO 2 emissions for the average flow year with vegetation harvested or burned were 30,799 T/yr. Net emissions for the no removal of vegetation were 71,824 T/yr. Methane concentrations in the dam outflow were less than 0.8 mg/L after the first year and 0.4 mg/l after 5 years.
Characterization of Landslides Using Advanced Remote Sensing Techniques, Standard Monitoring Techniques, and Laboratory Testing

Two slope failures that affecting two interstates in the state of Arkansas were monitored using traditional surveying techniques (total station) and advanced remote sensing techniques (Light Detection And Ranging [LiDAR] and RAdio Detection and Ranging [RADAR]). One failure was located near Chester, AR (calibration site) and the other slope failure was located near Malvern, AR (validation site). The results of monitoring program completed at both sites (calibration and validation) and geotechnical explorations/laboratory testing (validation site) are discussed and compared in this case study. INTRODUCTION While individual slope failures are not as spectacular or costly as other natural disasters such as earthquakes, major floods, and tornadoes; slope failures are more widespread. In aggregate, the total financial loss due to slope failures is probably greater than that for any other single geologic hazard (Griffiths et al., 1999). The ability to precisely identify the extents of a landslide and to monitor and preemptively mitigate potential landslide disasters can help save money and ensure slope remediation is properly performed. During the past six years the Arkansas State Highway and Transportation Department (AHTD) has spent over nine million dollars repairing slope failures that have occurred in the state of Arkansas. Therefore, a necessity exists to quantitatively identify the surface extents, movement rates, and direction of movements of a given landslide using advanced remote sensing techniques. Specifically, the Gamma Portable RADAR Interferometer (GPRI-II) and a Leica 289 Geo-Congress 2013 © ASCE 2013
Simulations of Separated Flow around an Airfoil with Ice Shape using Hybrid RANS/LES Models

Accurate prediction of high Reynolds number flow fields around complex geometries requires turbulence models that have favorable characteristics with regard to numerical stability, computational cost, mesh sensitivity, and accuracy. In order to investigate the feasibility of a new Hybrid RANS/LES (HRL) model with respect to these characteristics, numerical simulations were performed over a rearward facing step at ReH = 37,000 and around a GLC-305 airfoil configured with a 22.5-minute glaze ice accretion at Re = 3.5x10 6 , M = 0.12, and α = 6°. In the case of rearward facing step flow, comparisons were made between simulation results that employed a RANS model (Shear Stress Transport (SST)), the Delayed Detached Eddy Simulation (DDES) model, and the new HRL model. Mean velocity profiles of the new HRL model predictions showed better agreement with experimental data, in comparison with RANS and DDES model predictions. Both RANS and the new HRL model predictions of the turbulent kinetic energy profiles exhibited qualitatively good agreement with the experimental measurements, while the DDES model results agreed less well. Simulations using the Detached Eddy Simulation (DES) model, DDES model, and the new HRL model were performed for the flow field analysis of the airfoil with ice shape. Computations of DES, DDES, and new HRL model are still not rigorously comparable to the experiments as these computations have not yet attained statistically stationary flow fields. However, the qualitative assessment of the computations shows that the new HRL model enhances shear layer breakup and rollup in the separated flow region more so than do either DES or DDES.
Quality Assessment of Urinary Organic Acid Analysis

The number of known inherited metabolic disorders resulting in an organic aciduria has increased steadily over the past two decades. Prompt and reliable detection is both clinically and technically demanding but is essential if appropriate treatment is to be undertaken. This is the first study of laboratory performance in the detection of these disorders to be undertaken in the UK. Some conditions were accurately identified by most laboratories: for example for maple syrup urine disease, 12 of 14 laboratories provided an appropriate response and medium chain acyl-CoA dehydrogenase deficiency was correctly identified by 15 of 17 laboratories. However, accuracy of detection was poorer for other conditions: for example, only eight of 17 laboratories detected tyrosinaemia type 1 and nine of 18 laboratories detected 4-hydroxybutyric aciduria. The strongest correlation with good performance was obtained by comparison with the extent of peak identification: r = 0.62, P = 0.002. The need for regular attendance at scientific symposia was also supported by a weaker positive correlation with the average score achieved, P = 0.08. Evidence also suggested that some of the laboratories with a low workload performed less well. No significant difference in performance could be demonstrated between the 17 laboratories who used gas chromatography-mass spectrometry and the six participants who used gas chromatography alone.
Radiographic Local Control of Spinal Metastases with Percutaneous Radiofrequency Ablation and Vertebral Augmentation.

BACKGROUND AND PURPOSE: Combination radiofrequency ablation and vertebral augmentation is an emerging minimally invasive therapy for patients with metastatic spine disease who have not responded to or have contraindications to radiation therapy. The purpose of this study was to evaluate the rate of radiographic local control of spinal metastases treated with combination radiofrequency ablation and vertebral augmentation. MATERIALS AND METHODS: We retrospectively reviewed our tumor ablation database for all patients who underwent radiofrequency ablation and vertebral augmentation of spinal metastases between April 2012 and July 2014. Tumors treated in conjunction with radiation therapy were excluded. Tumor characteristics, procedural details, and complications were recorded. Posttreatment imaging was reviewed for radiographic evidence of tumor progression. RESULTS: Fifty-five tumors met study inclusion criteria. Radiographic local tumor control rates were 89% (41/46) at 3 months, 74% (26/35) at 6 months, and 70% (21/30) at 1 year after treatment. Clinical follow-up was available in 93% (51/55) of cases. The median duration of clinical follow-up was 34 weeks (interquartile range, 15–89 weeks), during which no complications were reported and no patients had clinical evidence of metastatic spinal cord compression at the treated levels. CONCLUSIONS: Combination radiofrequency ablation and vertebral augmentation appears to be an effective treatment for achieving local control of spinal metastases. A prospective clinical trial is now needed to replicate these results.
Inverse Thermal Analysis of Steel Welds Using Solidification-Boundary Constraints

Inverse thermal analyses of structural steel deep-penetration welds are presented. These analyses employ a methodology that is in terms of numerical-analytical basis functions and constraint conditions for inverse thermal analysis of steady-state energy deposition in plate structures. These analyses provide parametric representations of weld temperature histories that can be adopted as input data to various types of computational procedures, such as those for prediction of solid-state phase transformations and mechanical response. In addition, these parameterized temperature histories can be used for inverse thermal analysis of welds corresponding to other welding processes whose process conditions are within similar regimes. The present study applies an inverse thermal analysis procedure that uses three-dimensional constraint conditions whose two-dimensional projections are mapped within transverse cross sections of experimentally measured solidification boundaries.
Tunable in-situ electro-polymerization of hydrogel films for microchip-based bioanalysis

Electro-polymerization phenomena have been previously investigated at the macroscale in the context of producing polymeric coatings over extended surface areas. But electrical actuation also offers exquisite local control of the polymerized films' position, morphology, and thickness, suggesting compelling advantages in microfluidic-based analysis systems. Here, we introduce a microfabricated platform incorporating arrays of individually addressable on-chip electrodes capable of generating discretely positioned electro-polymerized hydrogel films inside microchannels in timescales of ∼5 min. Sequential actuation of specific electrode pairs initiates localized propagation of anchored polyacrylamide gel films and permits directed control of their size, shape, and growth rate. In addition to precise positioning of hydrogel films, obstacles, and barriers within microchannel networks, our approach makes it possible to encapsulate macromolecules within the films during polymerization, suggesting utility in a host of areas including separations, sample purification, and immunoassays.
Treatment of tunneled dialysis catheter malfunction: revision versus exchange.

IntroductionExchange procedures involve tunneled dialysis catheter (TDC) removal and exchange over a wire, using the same exit site and venotomy site. Diagnostic imaging or intervention was general...
Abstract SY31-03: The future of combinations of immunomodulators with local radiation: toward a personalized immunotherapy approach

We have shown in multiple preclinical tumor models that ionizing radiation therapy can convert tumors refractory to immune checkpoint inhibitors and other immune modulators into responsive ones. Importantly, the elicited antitumor T cells rejected not only the irradiated tumor but also nonirradiated spontaneous metastases or synchronous palpable tumors (abscopal effect), demonstrating the potential of radiation to generate systemically effective antitumor immune responses. Investigations into the mechanisms underlying a successful response have highlighted a complex interaction between radiation and anti-CTLA-4 occurring at the priming and effector phase of the antitumor immune response. These data support a model whereby the irradiated tumor becomes a “live attenuated vaccine” resulting in marked expansion of a limited number of distinct T-cell clones within the tumor. Our data also suggest that generation of an in situ tumor vaccine by radiation is regulated by the intrinsic tumor immunogenicity, the host immune system, and the radiation regimen employed. The interaction of these three compartments determines the levels of immune modulating mediators in the tumor microenvironment, including interferon type I, transforming growth factor-b, and adenosine, which in turn control the number and state of activation of intratumoral dendritic cells, and the magnitude of the induced T-cell response. Thus, while radiation offers the promise of a simple treatment to achieve individualized vaccination against each patient9s own tumor, success is likely to be achieved by a personalized combination of the most effective radiation regimen and immune modulator(s). We have recently shown in non-small cell lung cancer patients with chemotherapy-refractory metastatic disease that the synergy of radiotherapy and anti-CTLA-4 can be translated in the clinic (NCT02221739). Analysis of tumor and peripheral blood from responding and non-responding patients are beginning to provide clues to potential biomarkers and underlying mechanisms of response. Overall, local radiotherapy is showing the potential to be an ideal partner for immunotherapy. Because of its universal use in cancer treatment it is tempting to test standard of care radiotherapy in combination with any immunotherapy. However, rational use of radiation regimens and targeting of specific immune suppressive factors preexisting or elicited by radiation in a given tumor will be needed to truly reveal radiation9s role in personalized immunotherapy. Citation Format: Sandra Demaria. The future of combinations of immunomodulators with local radiation: toward a personalized immunotherapy approach. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr SY31-03.
A method for imaging and spectroscopy using γ-rays and magnetic resonance

A new imaging and spectroscopy approach combines the ability of magnetic resonance imaging to manipulate nuclear spins with the high sensitivity of γ-ray detection, enabling a greatly reduced number of nuclei to be used compared to conventional NMR signal detection. Yuan Zheng and colleagues have devised a new imaging and spectroscopy approach that combines the ability of magnetic resonance imaging to manipulate nuclear spins with the high sensitivity of γ-ray detectors. In their scheme, dubbed polarized nuclear imaging or PNI, a small quantity of a radioactive tracer is introduced into the system, the polarization of which is then manipulated by conventional nuclear magnetic resonance (NMR) techniques. But rather than detecting weak radio-frequency signals associated with these tracers, PNI works by monitoring the anisotropic γ-ray emissions from the highly polarized nuclei—and as single γ-rays can be detected, the amount of tracer required is greatly reduced compared to conventional NMR signal detection. The new method should have immediate non-biological imaging and spectroscopy applications, and could perhaps eventually be used in medical diagnostics. Magnetic resonance imaging (MRI) provides fine spatial resolution, spectral sensitivity and a rich variety of contrast mechanisms for diagnostic medical applications1,2. Nuclear imaging using γ-ray cameras offers the benefits of using small quantities of radioactive tracers that seek specific targets of interest within the body3. Here we describe an imaging and spectroscopic modality that combines favourable aspects of both approaches. Spatial information is encoded into the spin orientations of tiny amounts of a polarized radioactive tracer using pulses of both radio-frequency electromagnetic radiation and magnetic-field gradients, as in MRI. However, rather than detecting weak radio-frequency signals, imaging information is obtained through the detection of γ-rays. A single γ-ray detector can be used to acquire an image; no γ-ray camera is needed. We demonstrate the feasibility of our technique by producing images and spectra from a glass cell containing only about 4 × 1013 atoms (about 1 millicurie) of the metastable isomer 131mXe that were polarized using the laser technique of spin-exchange optical pumping4. If the cell had instead been filled with water and imaged using conventional MRI, then it would have contained more than 1024 water molecules. The high sensitivity of our modality expands the breadth of applications of magnetic resonance, and could lead to a new class of radioactive tracers.
Working Photos: Propaganda, Participation, and the Visual Production of Memory in Nazi Germany

This article examines images of Germany's “working world” in the 1930s and 1940s. Analyzing photos from three different genres—factory photography, special-occasion industrial photography, and the work of nonprofessional photographers—it addresses a series of questions: How was the “working world” depicted in photographs from this period? What were the different modes, functions, and effects of visual representations of work and workers in these three genres? In what ways did these photographs contribute to the (visual) production and “shaping” of memory—in terms of worker experiences, as well as with respect to attempts by the National Socialists to promote ideological notions of community-building (Vergemeinschaftung)? The main argument is that photography served as an important tool for the mobilization and self-mobilization of German workers under the Nazi regime.
Charge redistribution in QM:QM ONIOM model systems: a constrained density functional theory approach

The ONIOM hybrid method has found considerable success in QM:QM studies designed to approximate a high level of theory at a significantly reduced cost. This cost reduction is achieved by treating o...
Infrared thermography in the diagnosis and management of vasculitis

Vasculitis is a clinical condition with associated diagnostic challenges due to nonspecific symptoms and lack of a confirmatory imaging modality. We report a case of a 39-year-old female patient who developed generalized malaise, lethargy, and headache. Laboratory evaluation showed elevated inflammatory markers. Conventional imaging studies including computed tomography and carotid duplex ultrasound were unremarkable. Infrared thermography revealed enhanced thermographic signals in the left carotid artery and aortic arch. Corticosteroid therapy was commenced, and the patient responded well. Follow-up infrared thermography at 6 months showed complete resolution of the thermographic pattern, and the patient remained symptom free.
Recurrent coarctation of aorta after Norwood operation in single ventricle patients; the case of the missing ideal stent

Key Points Recurrent coarctation postoperative Norwood is poorly tolerated in single ventricle patients. Although transcatheter balloon angioplasty is considered first line, it often leads to inadequate or non-durable relief of obstruction. Transcatheter stent implantation provides excellent relief of obstruction but necessitates staged redilation to account for somatic growth in children. Stent technology, delivery systems, and procedural techniques will need to evolve to obviate reported adverse events mainly due to patient size.
Digital Games about the Materiality of Digital Games // Juegos digitales sobre la materialidad de los juegos digitales

This article investigates the potential for digital games to advance environmentally responsible attitudes by attending to their own material conditions, since the production, consumption, and disposal of games and the platforms on which they run enact ecological harm. I examine how Tomorrow Corporation’s puzzle game Little Inferno (2012) and Molleindustria’s political mobile game Phone Story (2011) address their own participation in ecological harm through rendering visible the very games themselves being played as material commodities. In doing so, they acknowledge their own complicity as well as that of their players in existing processes of environmental degradation. Moreover, both games challenge conventional expectations of fun as harmless or inconsequential, since this environmental destruction results from digital entertainment. I argue that digital games advancing environmentally responsible attitudes must address the ecological devastation tied to their materiality as well as support players in accepting responsibility for and remedying the harm players enact. Consequently, digital games of environmental responsibility must also question the dominant mode of fun that drives ecological devastation by reminding us that we dwell in a world where we need to be responsible for the fun we choose to have. Resumen Este articulo investiga el potencial de los juegos digitales para fomentar actitudes responsables hacia el medioambiente atendiendo a sus propias condiciones materiales, ya que la produccion, el consumo, y el desecho de los juegos y de las plataformas en las que funcionan representan dano ecologico. Examino como el puzle Little Inferno (2012) de Tomorrow Corporation y el juego politico para movil Phone Story (2011) de Molleindustria abordan su propia participacion en el dano ecologico haciendo visible el que los juegos en si mismos sean productos materiales. Al hacerlo, reconocen su propia complicidad, asi como la de los jugadores en los procesos de degradacion medioambiental. Ademas, ambos juegos desafian las expectativas convencionales de la diversion como algo inofensivo e intrascendente, ya que esta destruccion medioambiental resulta del entretenimiento digital. Argumento que los juegos digitales que promueven actitudes responsables hacia el medioambiente deben abordar la devastacion ecologica vinculada a su materialidad, asi como animar a los jugadores a que acepten su responsabilidad y corrijan el dano que hacen. En consecuencia, los juegos digitales con responsabilidad medioambiental deben tambien cuestionar la forma dominante de diversion que conlleva devastacion ecologica recordandonos que vivimos en un mundo en el que necesitamos ser responsables de la diversion que elegimos tener.
PROCESS SKILL ERROR: THE MAJORITY STUDENT’S ERROR IN PROBLEM SOLVING OF INTEGRAL CALCULUS

There is high unpassed value of students in Mathematics Departmen UMS at Integral Calculus lecture. It is predicted that there are so many students have difficulties in Integral Calculus. Data from mid exam at academic year 2016/2017 showed that there are 80,87% from 115 students got score under 63. It is indicated that there are so many students’s error in solving integral calculus problems. Integral Calculus is one of basic lecture which is prerequisite of other complex lecture. Knowing the error’s position and the factor that caused student’s error would help lecturer pay attention in integral calculus learning. Thus, the aim of this research is identifiying error’s position that are done by students and analyzing causative factor in solving Integral Kalkulus problems. Kind of this research is qualitative description. Technique of collecting data is test and interview. This research uses technique-triangulation for validating data, it is by documentation and interview. Meanwhile, the steps for analyzing data are data reduction, data presentation, and conclusion. The result of this research showed that there is 41,40% error with type process skill error in solving Integral Calculus problems. Besides, types of student’s error in solving Integral Calculus problems are transformation error, comprehension error, and reading error. There is no encoding error that found in this research. Causative factors of that student’s error are (1) students did not careful in reading the problems, writing mathematics siymbol include symbol of integral, and calculating, (2) low of prerequisite material mastery and concept of basic mathematics, (3) low of undestanding of material and concept of integral, (4) students could not identify the characteristics or types of probles to determine the appropriate technique of integration, and (5) the use of formula which is not appropriate and not suitable with problem’s solution
Angiographic "Blush" After Stereotactic Radiosurgery Ablation of Residual Arteriovenous Malformation in Pediatric Patient: Case Report and Review of Literature.

Introduction While surgical resection remains a primary treatment for accessible arteriovenous malformations (AVMs), stereotactic radiosurgery (SRS) has become thoroughly integrated into the AVM armamentarium; however, delayed sequelae of this treatment have become evident with increased long-term follow-up. To our knowledge, this is the second case of an aberrant local arterial angiographic blush without early venous drainage or an associated lesion following AVM SRS. Case Description An 8-year-old female presented with a ruptured 4-cm right medial frontal periventricular Spetzler-Martin grade 3 AVM with isolated intraventricular hemorrhage. She underwent subtotal resection followed by SRS. Six years later, diagnostic cerebral angiography demonstrated a prominent arterial-phase filling microvasculature without early venous drainage in the region of the irradiated residual AVM nidus. Conclusion Although there is a paucity of information on angiographic blush following AVM SRS, consensus in the literature suggests that without early venous drainage, these lesions appear to pose an insignificant threat to the patient. These angiographic findings may be on a spectrum of delayed cerebrovascular radiation changes, and thus indefinite follow-up may be considered, especially in pediatric patients.
The Effect of Fission Density on Fission-Gas Release

(1968). The Effect of Fission Density on Fission-Gas Release. Nuclear Science and Engineering: Vol. 32, No. 3, pp. 430-431.
Semiotics in Husserl’s Logical Investigations

Husserl begins the first of his Logical Investigations 1 by examining what he calls “The Essential Distinctions.” The first distinction he makes is between two kinds of sign, indications and expressions, Anzeigen and Ausdrucke Notice how he proceeds here at the start of his phenomenology, at the point where he is analyzing consciousness and defming his terms for the very first time. He does not begin his philosophy by looking inward at consciousness. His access to intentional acts is not by introspection. Rather, his access is through the public, palpable, and worldly phenomena of signs, both indicative and expressive. Signs are public things, they are “outside” the mind: they are sounds, marks, arrangements of objects, a wave of the hand, a pile of stones. It is by examining such public things that Husserl gains access to intentionality and makes distinctions within it.
Die trübe Kristall-Kugel

Zweimal in den letzten 15 Jahren wurden von Fachleuten auf dem biologischen Gebiete uberraschend falsche Voraussagen gemacht. Fruh in den 50er Jahren wurde eine zufriedenstellende Herz-Lungen-Maschine als Unmoglichkeit betrachtet; Homotransplantation von Geweben im Menschen wurde als ein visionarer Traum angesehen. In dieser kurzen Zeitspanne wurde gezeigt, das beides moglich war.
Differential Susceptibility of Rat Retinal Ganglion Cells Following Optic Nerve Crush

Retinal ganglion cells (RGCs) are a heterogeneous group of cells, comprised of numerous subpopulations, that work together to send visual information to the brain. In numerous blinding disorders termed optic neuropathies, RGCs are the main cell type affected leading to degeneration of these cells and eventual loss of vision. Previous studies have identified and characterized RGC subtypes in numerous animal systems, with only a handful of studies demonstrating their differential loss in response to disease and injury. Thus, efforts of the current study utilized an optic nerve crush (ONC) model to characterize the loss of RGCs and disease phenotypes associated with this injury. Additionally, the loss of RGC subtypes including direction selective-, alpha-, and ip-RGCs following ONC was explored. Results of this study demonstrated the differential loss of RGC subtypes with a high susceptibility for loss of alpha- and direction selective-RGCs and the preferential survival of ip-RGCs following ONC and allows for the establishment of additional studies focused on mechanisms and loss of these cells in optic neuropathies. Additionally, these results put important emphasis on the development of therapeutics targeted at the loss of specific subtypes as well as cellular replacement following injury and disease.
From "bedside" to "bench" and back: A translational approach to studying dopamine dysfunction in schizophrenia.

Abstract Despite multiple lines of research, a mechanistic understanding of schizophrenia remains elusive. Neuroimaging studies have yielded observations that can be used in translational studies in animals to attempt to uncover their cellular and circuit basis and their significance for the diseased human brain. Enhanced D2 stimulation in the striatum is a well replicated and established observation in patients with schizophrenia. This “bedside” observation was reproduced “at the bench” level by creating a transgenic mouse overexpressing D2 receptors in dorsal striatum (D2R-OE mouse). The D2R-OE mouse showed multiple behavioral, molecular, electrophysiological and anatomical alterations. Some of these are consistent with findings in patients with schizophrenia, providing construct validity to the model and mechanistic insights for the observations made in humans. Other findings were novel, and provide an opportunity for a reverse translational effort back into the clinic. In this review we will summarize the process of translation and back translation from the D2R-OE mouse and describe the insights into the pathophysiology of the disease gained through this type of translational work.
Learning needle tip localization from digital subtraction in 2D ultrasound

This paper addresses localization of needles inserted both in-plane and out-of-plane in challenging ultrasound-guided interventions where the shaft and tip have low intensity. Our approach combines a novel digital subtraction scheme for enhancement of low-level intensity changes caused by tip movement in the ultrasound image and a state-of-the-art deep learning scheme for tip detection. As the needle tip moves through tissue, it causes subtle spatiotemporal variations in intensity. Relying on these intensity changes, we formulate a foreground detection scheme for enhancing the tip from consecutive ultrasound frames. The tip is augmented by solving a spatial total variation regularization problem using the split Bregman method. Lastly, we filter irrelevant motion events with a deep learning-based end-to-end data-driven method that models the appearance of the needle tip in ultrasound images, resulting in needle tip detection. The detection model is trained and evaluated on an extensive ex vivo dataset collected with 17G and 22G needles inserted in-plane and out-of-plane in bovine, porcine and chicken phantoms. We use 5000 images extracted from 20 video sequences for training and 1000 images from 10 sequences for validation. The overall framework is evaluated on 700 images from 20 sequences not used in training and validation, and achieves a tip localization error of 0.72 ± 0.04 mm and an overall processing time of 0.094 s per frame (~ 10 frames per second). The proposed method is faster and more accurate than state of the art and is resilient to spatiotemporal redundancies. The promising results demonstrate its potential for accurate needle localization in challenging ultrasound-guided interventions.
A Draft Map of Rhesus Monkey Tissue Proteome for Biomedical Research

Though the rhesus monkey is one of the most valuable non-human primate animal models for various human diseases because of its manageable size and genetic and proteomic similarities with humans, proteomic research using rhesus monkeys still remains challenging due to the lack of a complete protein sequence database and effective strategy. To investigate the most effective and high-throughput proteomic strategy, comparative data analysis was performed employing various protein databases and search engines. The UniProt databases of monkey, human, bovine, rat and mouse were used for the comparative analysis and also a universal database with all protein sequences from all available species was tested. At the same time, de novo sequencing was compared to the SEQUEST search algorithm to identify an optimal work flow for monkey proteomics. Employing the most effective strategy, proteomic profiling of monkey organs identified 3,481 proteins at 0.5% FDR from 9 male and 10 female tissues in an automated, high-throughput manner. Data are available via ProteomeXchange with identifier PXD001972. Based on the success of this alternative interpretation of MS data, the list of proteins identified from 12 organs of male and female subjects will benefit future rhesus monkey proteome research.
Optimised contact patch system on an F3000 car

Michelin has developed a new suspension system designed mainly for racing and high-performance cars. This system maximises grip and wear performance by optimising the position of the tyre relative to the road surface.
Judicial engagement in classical Liberal public governance: a response and extension to Aligica, Boettke, and Tarko

This work considers the role that the judiciary and administrative law doctrines, like judicial deference, would have within the ideal classical liberal administrative state theorized by (Aligica PD, Boettke P, Tarko V, Public governance and the classical-Liberal perspective. Oxford University Press, New York, 2019) in their book Public Governance and the Classical-Liberal Perspective. I argue that even in an environment in which the administrative state is overhauled, that merely changing the incentives and institutions of public administration would not resolve all of the concerns regarding administrative agencies’ behavior nor the courts’ response to their actions. Within this theorized classically liberal system of public administration, there still exists the potential for administrative actions to undermine the proper separation of powers and checks and balances. Such issues could ultimately allow even this more ideal system to devolve into unchecked state power. Therefore, as a check on this potential, the judiciary would still play a necessary within (Aligica PD, Boettke P, Tarko V, Public governance and the classical-Liberal perspective. Oxford University Press, New York, 2019) classical liberal administrative state. To maximize personal freedom and liberty, I argue such a role would also require the courts to reform their current overly deferential stance regarding delegation of authority to administrative agencies, act as an impartial venue of redress for those harmed by the administrative state, and resolve ambiguous delegations of power.
Resilience versus Energy Tradeoffs of Emerging Device Memory Hierarchies: A Survey and Architecture Exploration

A significant shift from conventional memory stack design to novel architectures is required to reduce the processor-memory speed gap. This transformation will be realized through the deployment of the revolutionary memory technologies. The eDRAM and STT-RAM are among the list of alternative memory solutions. Each of these solutions offer various desired and unwanted characteristics. In this paper, we demonstrate multiple optimization approaches for selecting the optimal memory technology in CMP.
Positive Youth Development as an Improvement Resource in Odds-Beating Secondary Schools.

This multiple case study examines practices of educators in high schools called “odds-beaters”. These schools are exemplary in that they consistently achieve better-than-predicted graduation outcom...
Cola-GNN: Cross-location Attention based Graph Neural Networks for Long-term ILI Prediction

Forecasting influenza-like illness (ILI) is of prime importance to epidemiologists and health-care providers. Early prediction of epidemic outbreaks plays a pivotal role in disease intervention and control. Most existing work has either limited long-term prediction performance or fails to capture spatio-temporal dependencies in data. In this paper, we design a cross-location attention based graph neural network (Cola-GNN) for learning time series embeddings in long-term ILI predictions. We propose a graph message passing framework to combine graph structures (e.g., geolocations) and time-series features (e.g., temporal sequences) in a dynamic propagation process. We compare the proposed method with state-of-the-art statistical approaches and deep learning models. We conducted a set of extensive experiments on real-world epidemic-related datasets from the United States and Japan. The proposed method demonstrated strong predictive performance and leads to interpretable results for long-term epidemic predictions.
"Breast Is Best, But…" According to Childcare Administrators, Not Best for the Childcare Environment.

Background: Nearly 74% of U.S. mothers work full-time and employment is a cited reason for stopping breastfeeding. In the effort to increase breastfeeding duration, childcare providers could facilitate continuation of human milk feeding when mothers return to work. Yet, mothers report receiving little support when transitioning infants into childcare. Objective: Explore the themes of comfort with human milk and formula feeding among childcare administrators near Tampa, Florida. Material and Methods: Twenty-eight childcare administrators participated in semistructured interviews regarding policies and perceptions about infant feeding practices at their center. Using Applied Thematic Analysis, interview themes were identified. Results: Most administrators agreed "breastfeeding is best." However, they expressed discomfort with mothers breastfeeding at the center and perceived risk with handling and feeding human milk. These perceptions are illustrated through the theme "Formula feeding is normative" and four emergent subthemes: "Human milk is potentially harmful," "People are uncomfortable with breastfeeding in public," "I'm not the expert," and "'Breastfeeding is best', in theory." Conclusion: While breastfeeding may be best for health, from the childcare administrators' perspectives, it may not be best for the childcare environment. A cultural shift may be needed to change norms and perceptions in the childcare environment to support mothers in their effort to provide human milk. Perhaps it is time for a new message, such as "We can help you."
Liver transplantation in COVID-19 positive patients.

We read with great interest the article by Rouphael et al. in the American Journal of Transplantation,(1) and would like to highlight several points. First, the title and the introduction suggest that a liver transplant was performed in a recipient who was positive for SARS-CoV2. However, the most recent preoperative reverse transcriptase polymerase chain reaction (RT-PCR) testing was, in fact, negative.
Augmenter of Liver Regeneration Regulates Cellular Iron Homeostasis by Modulating Mitochondrial Transport of ATP-Binding Cassette B8

Abstract Chronic loss of Augmenter of Liver Regeneration (ALR) results in mitochondrial myopathy with cataracts, however, the mechanism for this disorder remains unclear. Here, we demonstrate that loss of ALR, a principal component of the MIA40/ALR protein import pathway, results in impaired cytosolic Fe/S cluster biogenesis in mammalian cells. Mechanistically, MIA40/ALR facilitates the mitochondrial import of ATP binding cassette (ABC)-B8, an inner mitochondrial membrane protein required for cytoplasmic Fe/S cluster maturation, through physical interaction with ABCB8. Downregulation of ALR impairs mitochondrial ABCB8 import, reduces cytoplasmic Fe/S cluster maturation, and increases cellular iron through the iron regulatory protein-iron response element system. Our finding provides a mechanistic link between MIA40/ALR import machinery and cytosolic Fe/S cluster maturation through the mitochondrial import of ABCB8, and offers a potential explanation for the pathology seen in patients with ALR mutations.