cssi/SciSciGPT-SciSciNet huggingface dataset:
Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines

A diastereo- and enantioselective CuH-catalyzed method for the preparation of highly functionalized indolines is reported. The mild reaction conditions and high degree of functional group compatibility as demonstrated with substrates bearing heterocycles, olefins, and substituted aromatic groups, renders this technique highly valuable for the synthesis of a variety of cis-2,3-disubstituted indolines in high yield and enantioeselectivity.
Are Bald-Faced Lies Deceptive after All?

According to the traditional philosophical definition, you lie if and only if you say something that you believe to be false and you intend to deceive someone into believing what you say. However, philosophers have recently noted the existence of bald-faced lies, lies which are not intended to deceive anyone into believing what is said. As a result, many philosophers have removed deception from their definitions of lying. According to Jennifer Lackey, this is ‘an unhappy divorce’ because it precludes an obvious explanation of the prima facie wrongness of lying. Moreover, Lackey claims that there is a sense of deception in which all lies are deceptive. In this paper, I argue that bald-faced lies are not deceptive on any plausible notion of deception. In addition, I argue that divorcing deception from lying may not be as unhappy a result as Lackey suggests.
Facile coupling of propargylic, allylic and benzylic alcohols with allylsilane and alkynylsilane, and their deoxygenation with Et3SiH, catalyzed by Bi(OTf)3 in [BMIM][BF4] ionic liquid (IL), with recycling and reuse of the IL

Allyltrimethylsilane (allyl-TMS) reacts with propargylic alcohols 1a–1d in the presence of 10% Bi(OTf)3 in [BMIM][BF4] solvent to furnish the corresponding 1,5-enynes in respectable isolated yields (87–93%) at room temperature. The utility of Bi(OTf)3 as a superior catalyst was demonstrated in a survey study on coupling of allyl-TMS with 1a employing several metallic triflates (Bi, Ln, Al, Yb) as well as, B(C6F5)3, Zn(NTf2)2 and Bi(NO3)3·5H2O. Coupling of cyclopropyl substituted propargylic alcohol 1e with allyl-TMS gave the skeletally intact 1,5-enyne and a ring opened derivative as a mixture. Coupling of propargylic/allylic alcohol 1f with allyl-TMS resulted in allylation at both benzylic (2 isomers) and propargylic positions, as major and minor products respectively. The scope of this methodology for allylation of a series of allylic and benzylic alcohols was explored. Chemoselective reduction of a host of propargylic, propagylic/allylic, bis-allylic, allylic, and benzylic alcohols with Et3SiH was achieved in high yields with short reaction times. The same approach was successfully applied to couple representative propargylic and allylic alcohols with 1-phenyl-2-trimethylsilylacetylene. The recovery and reuse of the ionic liquid (IL) was gauged in a case study with minimal decrease in isolated yields after six cycles.
Robust cyclohexanone selective chemiresistors based on single-walled carbon nanotubes.

Functionalized single-walled carbon nanotube (SWCNT)-based chemiresistors are reported for a highly robust and sensitive gas sensor to selectively detect cyclohexanone, a target analyte for explosive detection. The trifunctional selector has three important properties: it noncovalently functionalizes SWCNTs with cofacial π–π interactions, it binds to cyclohexanone via hydrogen bond (mechanistic studies were investigated), and it improves the overall robustness of SWCNT-based chemiresistors (e.g., humidity and heat). Our sensors produced reversible and reproducible responses in less than 30 s to 10 ppm of cyclohexanone and displayed an average theoretical limit of detection (LOD) of 5 ppm.
Evaluating the Feasibility to Use Microgrids as a Resiliency Resource

Regulated electricity utilities are required to provide safe and reliable service to their customers at a reasonable cost. To balance the objectives of reliable service and reasonable cost, utilities build and operate their systems to operate under typical historic conditions. As a result, when abnormal events such as major storms or disasters occur, it is not uncommon to have extensive interruptions in service to the end-use customers. Because it is not cost effective to make the existing electrical infrastructure 100% reliable, society has come to expect disruptions during abnormal events. However, with the increasing number of abnormal weather events, the public is becoming less tolerant of these disruptions. One possible solution is to deploy microgrids as part of a coordinated resiliency plan to minimize the interruption of power to essential loads. This paper evaluates the feasibility of using microgrids as a resiliency resource, including their possible benefits and the associated technical challenges. A use-case of an operational microgrid is included.
Pyridin-2-one Synthesis Using Ester Enolates and Aryl Aminoaldehydes and Ketones

An aldol-like cyclocondensation has been used to prepare heterocyclic-fused pyridin-2-ones from aminoaldehydes and ketones upon treatment with a lithium enolate of ethyl acetate or α-substituted acetates. These motifs are present in a large number of biologically active natural products and synthetic compounds and can be accessed using mild reaction conditions using readily available starting materials. This methodology allows access to pyrimidinopyridin-2-ones, pyrazolopyridin-2-ones, and pyridopyridazine diones with varying substitution patterns.
Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides

A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process to overcome the isomerization and β-hydride elimination problems that are associated with the use of secondary nucleophiles, and that have limited the analogous Pd-catalyzed systems. The impact of salt additives was also investigated. It was found that the presence of LiBF4 dramatically improves both isomeric retention and yield for challenging substrates.
INVESTMENT BANKS IN DUAL ROLES: ACQUIRER M&A ADVISORS AS UNDERWRITERS

We analyze the dual role of investment banks that provide advice to acquiring firms and act as underwriters on the securities issued to finance the acquisition. We find that the dual role of acquirer advisors is associated with lower acquirer announcement returns, higher target announcement returns, higher acquisition premiums, faster completion speeds, and higher divestiture rates. The dual role of the acquirer advisor does not lead to lower underwriting fees or issue costs. Our results are robust to controlling for the endogeneity of selection of the acquirer advisor as underwriter on the security issue used to finance the acquisition.
A New Approach to Stock Market Execution

The Financial Markets Group of the Federal Reserve Bank of Chicago has a keen interest in frequent batch auctions as a potential tool to diminish the utility of raw speed in executing trades on electronic financial markets. The Chicago Stock Exchange has received approval from the Securities and Exchange Commission to launch an innovative variant of batch auctions, the CHX SNAP auction. This article describes the CHX SNAP auction concept in great detail. If commercially successful, the CHX SNAP auction would allow institutional traders to leave hidden resting equity orders at the CHX out of the vision of digital traders who might otherwise attempt to profit from such knowledge.
Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver

Disturbances in protein folding and membrane compositions in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins-PERK (PEK/EIF2AK3), IRE1, and ATF6-is activated by ER stress. PERK phosphorylation of eIF2 represses global protein synthesis, lowering influx of nascent polypeptides into the stressed ER, coincident with preferential translation of ATF4 (CREB2). In cultured cells, ATF4 induces transcriptional expression of genes directed by the PERK arm of the UPR, including genes involved in amino acid metabolism, resistance to oxidative stress, and the proapoptotic transcription factor CHOP (GADD153/DDIT3). In this study, we characterize whole-body and tissue-specific ATF4-knockout mice and show in liver exposed to ER stress that ATF4 is not required for CHOP expression, but instead ATF6 is a primary inducer. RNA-Seq analysis indicates that ATF4 is responsible for a small portion of the PERK-dependent UPR genes and reveals a requirement for expression of ATF4 for expression of genes involved in oxidative stress response basally and cholesterol metabolism both basally and under stress. Consistent with this pattern of gene expression, loss of ATF4 resulted in enhanced oxidative damage, and increased free cholesterol in liver under stress accompanied by lowered cholesterol in sera.
Teaching Lawyering With Heart in the George Washington University Law School Domestic Violence Project

The Domestic Violence Project (DVP) began as an experiment but has become my favorite model for teaching law students about domestic violence work. The heart of the course is its emphasis on developing awareness of and compassion for the personally and emotionally challenging dimensions of domestic violence work. I achieve this (i) through an intensive and personal dialogue with students through written journals and responses; (ii) by inviting students to consider creative expression for their final project, and (iii) by teaching students about vicarious trauma and encouraging their understanding of it in themselves and other system players. Students seem to experience this course as an oasis of holistic professional and personal growth within the often dispiriting experience of law school.
Assessing firm behavior in carve-out markets: Evidence on the impact of carve-out policy

Abstract Airlines wanting to cooperatively set prices for their international air travel service must apply to the relevant authorities for antitrust immunity (ATI). While cooperation may yield benefits, it can also have anti-competitive effects in markets where partners competed prior to receiving ATI. A carve-out policy forbids ATI partners from cooperating in markets policymakers believe will be most harmed by anti-competitive effects. We examine carve-out policy applications to three ATI partner pairings, and find evidence more consistent with cooperative pricing in carve-out markets in spite of the policy, calling into question the effectiveness of the policy in achieving intended market outcomes.
Provenance for system troubleshooting

System administrators use a variety of techniques to track down and repair (or avoid) problems that occur in the systems under their purview. Analyzing log files, cross-correlating events on different machines, establishing liveness and performance monitors, and automating configuration procedures are just a few of the approaches used to stave off entropy. These efforts are often stymied by the presence of hidden dependencies between components in a system (e.g., processes, pipes, files, etc). In this paper we argue that system-level provenance (metadata that records the history of files, pipes, processes and other system-level objects) can help expose these dependencies, giving system administrators a more complete picture of component interactions, thus easing the task of troubleshooting.
Double-diffusive lock-exchange gravity currents

Double-diffusive lock-exchange gravity currents in the fingering regime are explored via two- and three-dimensional Navier–Stokes simulations in the Boussinesq limit. Even at modest Reynolds numbers, for which single-diffusive gravity currents remain laminar, double-diffusive currents are seen to give rise to pronounced small-scale fingering convection. The front velocity of these currents exhibits a non-monotonic dependence on the diffusivity ratio and the initial stability ratio. Strongly double-diffusive currents lose both heat and salinity more quickly than weakly double-diffusive ones, and they lose salinity more quickly than heat, so that the density difference driving them increases. This differential loss of heat and salinity furthermore results in the emergence of strong local density maxima and minima along the top and bottom walls in the gate region, which in turn promote the formation of secondary, counterflowing currents along the walls. These secondary currents cause the flow to develop a three-layer structure. The late stages of the flow are dominated by currents flowing oppositely to the original ones. Three-dimensional simulation results are consistent with the trends observed in a two-dimensional parametric study. A detailed analysis of the energy budget demonstrates that strongly double-diffusive currents can release several times their initially available potential energy, and convert large amounts of internal energy into mechanical energy via scalar diffusion. Scaling arguments based on the simulation results suggest that even low Reynolds number double-diffusive gravity currents are governed by a balance of buoyancy and turbulent drag.
A formalism and a verification method for bus-based systems

Bus-based systems consist of many similar components which communicate through a fixed channel. We propose a formal model for such systems, using finite-state automata to model behavior of components, and logic formulas to model bus arbitration. For this purpose, we define the indexed propositional logic, show that it has a small model property, and use that property to construct an abstraction of bus-based systems which does not depend on the actual number of components. We show that the proposed formalism can be used to model buses at various levels of abstraction.
Impact of Organizational Culture on Technology Use in a Developing Country.

Governments all over the world are spending millions in information technology to collect and distribute valuable information to their citizens. Unified Theory of Acceptance and Use of Technology (UTAUT) is a useful model for managers to assess the likelihood of acceptance of a new technology within an organization. In this paper, we consider organizational culture as an antecedent to the UTAUT model to evaluate factors that influence users’ acceptance and use of the Internet technology. We investigated the role of organizational culture in the adoption of Internet technology in a government agency in a developing country, India. We found that organizational culture influences adoption of Internet technology. We also found that the UTAUT is a valid model that can explain technology adoption in a developing country.
Combining Planning and Motion Planning

Robotic manipulation is important for real, physical world applications. General Purpose manipulation with a robot (eg. delivering dishes, opening doors with a key, etc.) is demanding. It is hard because (1) objects are constrained in position and orientation, (2) many non-spatial constraints interact (or interfere) with each other, and (3) robots may have multidegree of freedoms (DOF). In this paper we solve the problem of general purpose robotic manipulation using a novel combination of planning and motion planning. Our approach integrates motions of a robot with other (non-physical or external-to-robot) actions to achieve a goal while manipulating objects. It differs from previous, hierarchical approaches in that (a) it considers kinematic constraints in configuration space (C-space) together with constraints over object manipulations; (b) it automatically generates high-level (logical) actions from a C-space based motion planning algorithm; and (c) it decomposes a planning problem into small segments, thus reducing the complexity of planning.
NSAIDS: patterns of usage and side effects.

For best results in patients with arthritic disease, three major protocols are cardinal. The first is adequate dosage—i.e., relatively high anti-inflammatory levels. The second is to give the drug a reasonable trial—three or four weeks. Finally, although the NSAIDs are generally similar, pharmacologic differences among them may be clinically pertinent.
Mutation is a sufficient and robust predictor of genetic variation for mitotic spindle traits in Caenorhabditis elegans

Different types of phenotypic traits consistently exhibit different levels of genetic variation in natural populations. There are two potential explanations: Either mutation produces genetic variation at different rates or natural selection removes or promotes genetic variation at different rates. Whether mutation or selection is of greater general importance is a longstanding unresolved question in evolutionary genetics. We report mutational variances (VM) for 19 traits related to the first mitotic cell division in Caenorhabditis elegans and compare them to the standing genetic variances (VG) for the same suite of traits in a worldwide collection C. elegans Two robust conclusions emerge. First, the mutational process is highly repeatable: The correlation between VM in two independent sets of mutation accumulation lines is ∼0.9. Second, VM for a trait is a good predictor of VG for that trait: The correlation between VM and VG is ∼0.9. This result is predicted for a population at mutation-selection balance; it is not predicted if balancing selection plays a primary role in maintaining genetic variation.
The endocrinology of anorexia nervosa and bulimia nervosa

Anorexia nervosa and bulimia nervosa are associated with multiple endocrine disturbances. These disturbances are reviewed with particular attention to the relative contributions of malnutrition versus other possible factors.
Tight Lower Bounds for Multiplicative Weights Algorithmic Families

We study the fundamental problem of prediction with expert advice and develop regret lower bounds for a large family of algorithms for this problem. We develop simple adversarial primitives, that lend themselves to various combinations leading to sharp lower bounds for many algorithmic families. We use these primitives to show that the classic Multiplicative Weights Algorithm (MWA) has a regret of (T*ln(k)/2)^{0.5} (where T is the time horizon and k is the number of experts), there by completely closing the gap between upper and lower bounds. We further show a regret lower bound of (2/3)* (T*ln(k)/2)^{0.5} for a much more general family of algorithms than MWA, where the learning rate can be arbitrarily varied over time, or even picked from arbitrary distributions over time. We also use our primitives to construct adversaries in the geometric horizon setting for MWA to precisely characterize the regret at 0.391/(\delta)^{0.5} for the case of 2 experts and a lower bound of (1/2)*(ln(k)/(2*\delta))^{0.5}, for the case of arbitrary number of experts k (here \delta is the probability that the game ends in any given round).
The Summit County Integrated Public Safety Initiative: Information Sharing in Law Enforcement

The Integrated Public Safety Initiative (IPSI) is a multi-party project aimed at establishing effective information sharing across all members of the law enforcement community within Sumit County in Connecticut (on the east coast of the United States).2 A regional software vendor, Blue Systems, Inc. (BSI), has been selected to provide the information sharing platform that forms the core of the initiative. In this capacity, BSI professionals are acting as the primary managers of the overall project effort. The project is envisioned as a multi-year effort, with the four central law enforcement entities in the county adopting the system in 2008 and additional public safety entitiesmigrated onto the platform over the next three (3) years.
Review: erythropoiesis-stimulating agents increase mortality in patients with cancer.

Source Citation Bohlius J, Schmidlin K, Brillant C, et al. Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet. 2...
Phased arrays for the new millennium

This is a survey paper summarizing the recent developments and future trends in passive, active bipolar and Monolithic Microwave Integrated Circuitry (MMIC) phased arrays for ground, ship, air and space applications. We cover the THAAD (formerly GBR), European COBRA and Israel BMD radar antennas; Dutch shipboard APAR; airborne US F-22 European AMSAR, Swedish AEDA, japan FSX and Israel Phalcon; Iridium (66 satellites in orbit for total of 198 antennas) and Globalstar MMIC spaceborne antenna systems; Thomson-CSF 4 inch MMIC wafer 94 GHz seeker antenna; digital beamforming; ferroelectric row-column scanning; optical electronic scanning for communications and radar; the MMIC C-band to Ku-band Advanced Shared Aperture Program (ASAP) antenna system for communications, radar, electronic countermeasures (ECM) and ESM; and continuous transverse stub (CTS) voltge-variable dielectric (VVD) antenna.
High-power linac for the spallation neutron source

The Spallation Neutron Source (SNS) will be the world's most intens!;: source of neutrons for fundamental science and industrial applications. In this paper, we review the physics requirements, design, construction, installation, and first commissioning results of the I-GeV, 1.4-MW average power RF linac for SNS. The overall project is 82 % complete, with most of the linac hardware manufactured and delivered to the SNS site. Commissioning of the first drift tube linac tanks was a success. Approximately 100 % of the beam was transmitted at full average current while achieving the emittance goal of less than 0.3 π mm-mrad.
Prognostic models for predicting posttraumatic seizures during acute hospitalization, and at 1 and 2 years following traumatic brain injury.

Summary Objective Posttraumatic seizures (PTS) are well-recognized acute and chronic complications of traumatic brain injury (TBI). Risk factors have been identified, but considerable variability in who develops PTS remains. Existing PTS prognostic models are not widely adopted for clinical use and do not reflect current trends in injury, diagnosis, or care. We aimed to develop and internally validate preliminary prognostic regression models to predict PTS during acute care hospitalization, and at year 1 and year 2 postinjury. Methods Prognostic models predicting PTS during acute care hospitalization and year 1 and year 2 post-injury were developed using a recent (2011–2014) cohort from the TBI Model Systems National Database. Potential PTS predictors were selected based on previous literature and biologic plausibility. Bivariable logistic regression identified variables with a p-value < 0.20 that were used to fit initial prognostic models. Multivariable logistic regression modeling with backward-stepwise elimination was used to determine reduced prognostic models and to internally validate using 1,000 bootstrap samples. Fit statistics were calculated, correcting for overfitting (optimism). Results The prognostic models identified sex, craniotomy, contusion load, and pre-injury limitation in learning/remembering/concentrating as significant PTS predictors during acute hospitalization. Significant predictors of PTS at year 1 were subdural hematoma (SDH), contusion load, craniotomy, craniectomy, seizure during acute hospitalization, duration of posttraumatic amnesia, preinjury mental health treatment/psychiatric hospitalization, and preinjury incarceration. Year 2 significant predictors were similar to those of year 1: SDH, intraparenchymal fragment, craniotomy, craniectomy, seizure during acute hospitalization, and preinjury incarceration. Corrected concordance (C) statistics were 0.599, 0.747, and 0.716 for acute hospitalization, year 1, and year 2 models, respectively. Significance The prognostic model for PTS during acute hospitalization did not discriminate well. Year 1 and year 2 models showed fair to good predictive validity for PTS. Cranial surgery, although medically necessary, requires ongoing research regarding potential benefits of increased monitoring for signs of epileptogenesis, PTS prophylaxis, and/or rehabilitation/social support. Future studies should externally validate models and determine clinical utility.
An adaptive scheme for digital protection of power transformers

The development of an adaptive scheme for digital differential protection of power transformers is described. The transformer status is monitored to decide if the transformer is disconnected or is in normal operating condition. When the transformer is energized, a two-state Kalman filter model monitors the transformer during normal operating conditions. The current transformer ratios and tap values are included in the algorithm to obtain an adaptive percentage differential characteristic. This adaptive scheme was tested on data obtained in the laboratory and proved to be highly accurate and fast. >
MULTIPHASE DISPERSIONS BY CRYSTALLIZATION PROCESSING

The interaction between second-phase particles and crystal-liquid interfaces in the solidification process has been studied in ground-based experiments and experiments under microgravity conditions. An analysis of these data with a view toward the solidification processing of composite materials reveals a pronounced difference between high entropy of fusion and low entropy of fusion matrix materials, as well as a pronounced effect of differences in the thermal conductivity of particles and liquid on the behavior of materials. Effects of liquid viscosity surface topography of the particles, particle chemistry, and overall particle shape examined.
Prospects for Integrative Citizenship in Research and Practice

The previous chapters presented theoretical and empirical advances in corporate social performance research. Part I addressed theory building problems, arguing for a better understanding of organizational dynamics instead of defaulting to the assumption of a strict dichotomy between economic performance and other important social goals. Certain organizational processes were identified, particularly the receptivity to values in executive decision making, that may mitigate perceived tradeoffs between these goals, theoretically aligning them to a greater extent than previously modeled. This emphasis on value-inclusive decision processes is important, given the findings presented in Part II that attending to economic, social, and ecological goals simultaneously can pay off while reducing financial risk for a firm. As a practical matter, it is also important to be able to point to a valid measure of socially responsible outcomes, such as that advanced in Chapter 8. We proposed the phrase ‘integrative corporate citizenship’ to convey this comprehensive approach to corporate social performance.
Alternative Behavioral Law and Economics

This chapter considers the psychological, methodological, and normative paths taken by behavioral law and economics ("BLE") and alternative paths that BLE might have taken, and might still take. The counterfactual BLE imagined here stresses the B in BLE, with behavioral approaches to legal problems being the focus rather than advocacy of any particular basic model of human cognition and motivation to compete with L&E’s dominant model. This change in focus would give priority to empirical studies in which particular legal institutions and specific legal tasks are simulated or studied in situ rather than to studies of abstract and general judgment and decision-making problems that may provide more theoretical bang but have less applied payoff in specific legal contexts.
Quality of Life and Poor Oral Health: A Comparison of Postmenopausal Women

Inter-relationships between traditional dental variables are becoming more evident in far reaching aspects of life, such as psychosocial interaction, self-esteem, overall health and even occupational performance. This study compares quality of life (QoL) in postmenopausal women (PMW) with poor oral health (POH) with QoL in PMW with good oral health. A total of 200 randomly recruited PMW received a dental evaluation and completed the Utian Quality of Life Survey. The participants were divided into POH and healthy groups based on a dental exam. Mean scores were calculated for each QoL item, domain and the overall summary score. For each of the four parameters for periodontitis diagnosis, periodontitis b s patients’ QoL outcomes were compared to those of healthy patients using a T-test with a threshold of significance at p < 0.05. QoL in all fields measured was significantly poorer in the POH patients compared to the healthy patients: occupational score (19.95 ± 5.35 vs. 27.56 ± 6.13), health score (18.02 ± 8.23 vs. 26.59 ± 6.45), emotional score (15.68 ± 10.22 vs. 21.15 ± 9.15), sexual score (6.2 ± 5.98 vs. 10.02 ± 5.35), and total score (60.21 ± 25.85 vs. 84.26 ± 22.35). This study finds that PMW with POH report significantly poorer quality of life. Clinicians caring for PMW should be aware that oral health impacts QoL and make appropriate referral decisions for patients’ dental care.
Security Controls for Monitored Use of USB Devices Based on the NIST Risk Management Framework

Universal Serial Bus (USB) is one of the most popular and extensively used technologies in the world due to its user friendly nature and ease of use. It is also one of the most widely targeted technologies by hackers. Hackers have discovered a vulnerability in the USB technology, known as "Bad USB", that allows them to plant and execute a malware at any desired time once the USB device is connected to the operating system (OS). The malware remains undetected from the security applications installed in the OS because it is embedded in the firmware of the USB device and security applications usually do not scan the firmware. This makes the malware pose a significant risk to the OS since it can stay undetected and can execute itself at a pre-planned time without the knowledge of the user or the security applications installed in the OS. This research paper aims to address this vulnerability and mitigate the risks posed by it by (i) building a Bad USB device and testing it in a controlled OS environment, studying the results and (ii) recommending security controls based on the U. S. National Institute of Standards and Technology risk management framework. The recommendations are divided into three categories, those are Technical, Operational and Management. Using the outlined solutions and following the recommendations provided in this paper, organizations and individual users can protect their information assets from being exploited by any risk posed by the Bad USB threat.
A new algorithm for “the LCS problem” with application in compressing genome resequencing data

The longest common subsequence (LCS) problem is a classical problem in computer science, and forms the basis of the current best-performing reference-based compression schemes for genome resequencing data. First, we present a new algorithm for the LCS problem. Using the generalized suffix tree, we identify the common substrings shared between the two input sequences. Using the maximal common substrings, we construct a directed acyclic graph (DAG), based on which we determine the LCS as the longest path in the DAG. Then, we introduce an LCS-motivated reference-based compression scheme using the components of the LCS, rather than the LCS itself. Our basic scheme compressed the Homo sapiens genome (with an original size of 3,080,436,051 bytes) to 15,460,478 bytes. An improvement on the basic method further reduced this to 8,556,708 bytes, or an overall compression ratio of 360. This can be compared to the previous state-of-the-art compression ratios of 157 (Wang and Zhang, 2011) and 171 (Pinho, Pratas, and Garcia, 2011). We propose a new algorithm to address the longest common subsequence problem. Motivated by our LCS algorithm, we introduce a new reference-based compression scheme for genome resequencing data. Comparative results against state-of-the-art reference-based compression algorithms demonstrate the performance of the proposed method.
AN ANALYSIS OF THE EFFECTIVENESS AND COST BENEFIT OF AN ENHANCED RECOVERY PROGRAMME FOR KNEE ARTHROPLASTY

An enhanced recovery programme for knee arthroplasty was introduced two years ago to our orthopaedic department. It involved the setting up of an educational programme for patients along with an extensive rehabilitation programme. The main aim of the programme is to provide an efficient and personalised service that results in an improved patient experience and fewer bed days following surgery. We carried out a retrospective study, randomly selecting 100 patients over a period of a year who were enrolled in the enhanced recovery programme. We analysed three main areas involving the pre-, peri- and post-operative period. We looked for any key factors that led to an increase or decrease in bed days. The re-admissions were analysed and the cost benefit was calculated. 99 patients were randomly selected and satisfied the inclusion criteria. We found that with the enhanced recovery programme the average length of stay for a knee arthroplasty was four days. There were no re-admissions within the population. We would like to share our enhanced recovery programme model as we feel it is a robust and effective way of providing a high level of care and decreasing the length of stay post-operatively.
Comparative aeronomy: Molecular ionospheres at Earth and Mars

The ionospheres in our solar system vary not only in their electron densities, but also in the dominance of atomic versus molecular ions at their altitudes of peak plasma density. With the exception of Earth's F-layer composed of atomic oxygen ions and electrons, all other planets have their peak ionospheric layers composed of molecular ions and electrons embedded in a dense neutral atmosphere. At Mars, both of its ionospheric layers have molecular ions, with the M1-layer at a lower altitude than the more robust M2-layer above it. The terrestrial ionosphere has a prominent region of molecular ions (the E-layer) below the dominant F-layer. In this paper, we explore the production and loss of molecular ion layers observed under the same solar irradiance conditions at Mars and Earth. We compare observations of M1 and M2 electron densities with terrestrial ionosonde data for the peak densities of the E- and F-layers during low, moderate and high solar flux conditions. The sub-solar peak densities of molecular ion layers have high correlations at each planet, as well as between planets, even though they are produced by separate portions of the solar spectrum. We use photo-chemical-equilibrium theory for layers produced by soft X-rays (M1 and E) versus the M2-layer produced by extreme ultraviolet (EUV) to identify the key parameters that cause similarities and differences. The yield of our comparative study points to the roles of secondary ionization and temperature dependent plasma recombination rates as areas most in need of further study at each planet.
Rapid Access Ice Drill: A new tool for exploration of the deep Antarctic ice sheets and subglacial geology

A new Rapid Access Ice Drill (RAID) will penetrate the Antarctic ice sheets in order to create borehole observatories and take cores in deep ice, the glacial bed and bedrock below. RAID is a mobile drilling system to make multiple long, narrow boreholes in a single field season in Antarctica. RAID is based on a mineral exploration-type rotary rock-coring system using threaded drill pipe to cut through ice using reverse circulation of a non-freezing fluid for pressure-compensation, maintenance of temperature and removal of ice cuttings. Near the bottom of the ice sheet, a wireline latching assembly will enable rapid coring of ice, the glacial bed and bedrock below. Once complete, boreholes will be kept open with fluid, capped and available for future down-hole measurement of temperature gradient, heat flow, ice chronology and ice deformation. RAID is designed to penetrate up to 3300 m of ice and take cores in <200 hours, allowing completion of a borehole and coring in ~10 d at each site. Together, the rapid drilling capability and mobility of the system, along with ice-penetrating imaging methods, will provide a unique 3-D picture of interior and subglacial features of the Antarctic ice sheets.
What prevents gravitational collapse in string theory

It is conventionally believed that if a ball of matter of mass M has a radius close to 2GM then it must collapse to a black hole. But string theory microstates (fuzzballs) have no horizon or singularity, and they do not collapse. We consider two simple examples from classical gravity to illustrate how this violation of our intuition happens. In each case, the ‘matter’ arises from an extra compact dimension, but the topology of this extra dimension is not trivial. The pressure and density of this matter diverge at various points, but this is only an artifact of dimensional reduction; thus, we bypass results like Buchadahl’s theorem. Such microstates give the entropy of black holes, so these topologically nontrivial constructions dominate the state space of quantum gravity.
Taking Stock of the Evidence on Micro-Financial Interventions

We review the empirical evidence on microfinance and asset grants to the ultra poor or microentrepreneurs, and assess our ability to account for this evidence using quantitative theory. Properly executed, these interventions can help segments of the population increase their income and consumption, but neither the empirical micro nor quantitative macro literatures give much reason to believe that such interventions can lead to wide-scale, transformative impacts akin to escaping aggregate poverty traps.
The Social Boundaries of Corporate Taxation

Historically, the tax law distinction between corporate and conduit treatment drew primarily on doctrinal understandings, treating state-law corporations as corporate for tax purposes and classifying unincorporated legal entities based on their resemblance to conventional state-law corporations. More recently, commentators and Treasury have abandoned these doctrinal touchstones in favor of efficiency, broadly construed, as the guiding principle in determining an entity’s tax classification. This Article argues that, while important, efficiency considerations should not function as the sole arbiter of the boundary between corporate and conduit tax treatment. First, classical corporate taxation is, in many ways, deeply embedded within a larger network of legal and social meanings. Classical corporate taxation operates in concert with, rather than separately from, these legal and social meanings. For this reason, the rules governing entities’ tax classification should take these interrelationships into account, if not as a primary norm, then as a secondary consideration when empirical or other uncertainties preclude a clear choice based on efficiency. The social boundaries of corporate taxation refer to the extent to which these types of nontax considerations implicate the Code’s structural distinction between corporations and conduits. Second, efficiency is often conceptually tractable as a metric, but this intuitive appeal can mask significant empirical uncertainties about behavioral responses, especially if policymakers possess limited information, have difficulty reversing inapposite decisions, or face other constraints. In these situations, policymakers should take cues from the broader legal and social context in which tax law operates. Finally, by claiming that corporate tax law is situated in broader legal and social contexts, this Article does not attempt to validate or valorize the independent merit of these other contexts. Instead, this Article advocates consistency across policy areas — “fit” within the broader legal and social framework — rather than particular policy prescriptions.
Algebraic matroids and set-theoretic realizability of tropical varieties

Abstract To each prime ideal in a polynomial ring over a field we associate an algebraic matroid and show that it is preserved under tropicalization. This gives a necessary condition for a tropical variety to be set-theoretically realizable from a prime ideal. We also show that there are infinitely many Bergman fans that are not set-theoretically realizable as the tropicalization of any ideal.
Analysis for errors of shunt outrange measurement based on finite element method

Thermoelectric coupling finite element model of 150A/75mV shunt was established, and temperature rises of them when the measuring current was over range were analyzed. Electromagnetic finite element model of shunt was established, And electrodynamic forces on manganin sheets of shunt were analyzed. Then, the measurement errors were estimated according to the results of temperature rises and electrodynamic forces, and the main aspects of measurement errors when measure outrange current were found in this paper.
Efficient probabilistic collision detection for non-convex shapes

We present new algorithms to perform fast probabilistic collision queries between convex as well as non-convex objects. Our approach is applicable to general shapes, where one or more objects are represented using Gaussian probability distributions. We present a fast new algorithm for a pair of convex objects, and extend the approach to non-convex models using hierarchical representations. We highlight the performance of our algorithms with various convex and non-convex shapes on complex synthetic benchmarks and trajectory planning benchmarks for a 7-DOF Fetch robot arm.
WHEN PROXIMAL FEMORAL FX FIXATION FAILS: SALVAGE OPTIONS

Although the vast majority of fractures of the proximal femur will heal with well-done internal fixation, occasionally failure of fixation will occur. Having effective salvage options is important to restore function and minimise complications. In general, it is logical to separate salvage options into those for fractures of the femoral neck, and those for fractures of the intertrochanteric region. Additionally, patient age and remaining bone stock should be considered. Femoral neck fracture fixation failure salvage, young patients: All efforts are focused on preserving the native femoral neck. Valgus producing osteotomy is typically indicated, and can be successful even with small patches of AVN. Femoral neck fracture fixation failure salvage, older patients: Total hip arthroplasty is generally most predictable. Be prepared for very poor bone quality. Supplement uncemented acetabular component with multiple screws. Be prepared to cement femoral component, if necessary. Intertrochanteric fracture fixation failure salvage, young patients: Repeat internal fixation attempts with fixed angle devices (such as a 95 degree blade plate) and bone grafting generally preferred. Avoid varus of proximal fragment and target inferior femoral head bone. Intertrochanteric fracture fixation failure salvage, older patients: Total hip arthroplasty preferred. Long stems to bypass femoral shaft stress risers and “calcar replacement” stems may be necessary due to proximal bone defects. Trochanteric fixation must be stable. Results are generally good but trochanteric complaints are common.
First‐principles identification of defect levels in Er‐doped GaN

Erbium (Er) doped GaN has been studied extensively for optoelectronic applications, yet its defect physics is still not well understood. In this work, we report a first-principles hybrid density functional study of the structure, energetics, and thermodynamic transition levels of Er-related defect complexes in GaN. We discover for the first time that ErGa–CN–VN, a defect complex of Er, a C impurity, and an N vacancy, and ErGa–ON–VN, a complex of Er, an O impurity, and an N vacancy, form defect levels at 0.18 eV and 0.46 eV below the conduction band, respectively. Together with ErGa–VN, a complex of Er and an N vacancy which has recently been found to produce a donor level at 0.61 eV, these defect complexes provide explanation for the Er-related defect levels observed in experiments. The role of these defects in optical excitation of the luminescent Er center is also discussed.
A Scan of CDC-Authored Articles on Legal Epidemiology, 2011-2015.

Objective:The Centers for Disease Control and Prevention (CDC) conducts research on legal epidemiology, the scientific study of law as a factor in the cause, distribution, and prevention of disease...
Prioritized garbage collection: explicit GC support for software caches

Programmers routinely trade space for time to increase performance, often in the form of caching or memoization. In managed languages like Java or JavaScript, however, this space-time tradeoff is complex. Using more space translates into higher garbage collection costs, especially at the limit of available memory. Existing runtime systems provide limited support for space-sensitive algorithms, forcing programmers into difficult and often brittle choices about provisioning. This paper presents prioritized garbage collection, a cooperative programming language and runtime solution to this problem. Prioritized GC provides an interface similar to soft references, called priority references, which identify objects that the collector can reclaim eagerly if necessary. The key difference is an API for defining the policy that governs when priority references are cleared and in what order. Application code specifies a priority value for each reference and a target memory bound. The collector reclaims references, lowest priority first, until the total memory footprint of the cache fits within the bound. We use this API to implement a space-aware least-recently-used (LRU) cache, called a Sache, that is a drop-in replacement for existing caches, such as Google's Guava library. The garbage collector automatically grows and shrinks the Sache in response to available memory and workload with minimal provisioning information from the programmer. Using a Sache, it is almost impossible for an application to experience a memory leak, memory pressure, or an out-of-memory crash caused by software caching.
Long-range exchange interaction between magnetic impurities in graphene

The effective spin exchange RKKY coupling between impurities (adatoms) on graphene mediated by conduction electrons is studied as a function of the strength of the potential part of the on-site energy $U$ of the electron-adatom interaction. With increasing $U$, the exchange coupling becomes long range, determined largely by the impurity levels with energies close to the Dirac points. When adatoms reside on opposite sublattices, their exchange coupling, normally antiferromagnetic, becomes ferromagnetic and resonantly enhanced at a specific distance where an impurity level crosses the Dirac point.
The Impacts of Neighborhoods on Intergenerational Mobility II: County-Level Estimates

We estimate the causal effect of each county in the United States on children’s incomes in adulthood. We first estimate a fixed effects model that is identified by analyzing families who move across counties with children of different ages. We then use these fixed effect estimates to (i) quantify how much places matter for intergenerational mobility, (ii) construct forecasts of the causal effect of growing up in each county that can be used to guide families seeking to move to opportunity, and (iii) characterize which types of areas produce better outcomes. For children growing up in low-income families, each year of childhood exposure to a one standard deviation (std. dev.) better county increases income in adulthood by 0.5%. There is substantial variation in counties’ causal effects even within metro areas. Counties with less concentrated poverty, less income inequality, better schools, a larger share of two-parent families, and lower crime rates tend to produce better outcomes for children in poor families. Boys’ outcomes vary more across areas than girls’ outcomes, and boys have especially negative outcomes in highly segregated areas. Areas that generate better outcomes have higher house prices on average, but our approach uncovers many “opportunity bargains”—places that generate good outcomes but are not very expensive.