cssi/SciSciGPT-SciSciNet huggingface dataset:
Interactions of calcium with the pyridine nucleotides.

Association constants were determined for the 1:1 interactions of calcium with NAD+, NADH, NADP+, and NADPH in aqueous systems (pH 7, 25 °C) by use of a calcium-sensitive electrode. The order of binding of calcium to these pyridine nucleotides appears to be NAD+ < NADH < NADP+ < NADPH with association constants of 0.2 × 102, 0.3 × 102, 0.9 × 102, and 2 × 102, respectively. Calorimetric experiments revealed that all of these interactions are endothermic with enthalpy changes of 1, 2, 2, and 3 kcal/mol, respectively.
Bulk electronic structure of YbInCu 4 from photoemission: A unique test of the single impurity model

The heavy fermion compound ${\mathrm{YbInCu}}_{4}$ presents a unique opportunity to test the single impurity model (SIM) owing to its isostructural phase transition at 42 K, whereby the Kondo temperature suddenly increases from 30 K above, to 400 K below the transition. Photoelectron spectroscopy (PES) at varying temperatures is well suited for this test. Previous researchers have claimed that PES probes only a subsurface region which differs from the bulk, thus rendering PES less than optimum for such a test. We present PES data in which a single-crystal sample was cooled through the phase transition only once in order to minimize defect formation. We find clear evidence of the bulk transition and no evidence for a subsurface region. The PES spectra do not agree with the predictions of the SIM and its approximate solution, the noncrossing approximation. We propose that only a periodic model is applicable to highly correlated, stoichiometric heavy fermion systems.
Non-Mendelian transmission of an apospory-specific genomic region in a reciprocal cross between sexual pearl millet (Pennisetum glaucum) and an apomictic F1 (P. glaucum × P. squamulatum)

We recently showed that aposporous apomixis, a form of gametophytic apomixis, is controlled by a single apospory-specific genomic region (ASGR) in both Pennisetum squamulatum and Cenchrus ciliaris. We present evidence that in a reciprocal cross between sexual pearl millet (P. glaucum) and an apomictic F1 (P. glaucum× P. squamulatum) the ASGR is not transmitted at the same rate. When pearl millet was used as the female parent and the apomictic genotype as the pollen donor, the ASGR was transmitted at a rate of 0.41 in a progeny of 57 plants, indicating a slight transmission ratio distortion. However, in a population of 52 rare sexual progenies characterized among a large progeny of a quasi-obligate apomict (an F1 hybrid of P. glaucum×P. squamulatum), the transmission rate of ASGR was only 0.12. This strong segregation distortion may have occurred at four different levels: (1) female meiosis, (2) during female gametophyte maturation, (3) upon fertilization with differential survival of embryos being a consequence of differential gene expression controlled by parent-of-origin specific effects (imprinting) and (4) at a later developmental stage of the embryo through an embryo/endosperm genetic incompatibility system.
FACTOR ANALYSIS AND ARBITRAGE PRICING IN LARGE ASSET ECONOMIES

Abstract The paper develops a framework for factor analysis and arbitrage pricing in a large asset economy modeled as one with a continuum of assets. It is shown that the assumptions of absence of arbitrage opportunities and that returns have a strict factor structure imply exact factor-pricing for a full measure of assets. Interpreting finite subsets of assets as random draws from the underlying economy, there is probability one that every asset in a finite sample is exactly factor-priced. It is further shown that approximate factor structures exist in general and that they can be chosen optimally according to a measure of their explanatory power. Factor structures in the present model are also robust to asset repackaging and to the use of proxies to approximate the true factors.Journal of Economic LiteratureClassification numbers: G1, G12, C14.
1993 US Petroleum engineering manpower supply and demand

Each year, the SPE Manpower Committee reports on the results of petroleum engineering manpower supply and demand surveys to inform SPE members about hiring patterns of engineers in the petroleum industry and the supply of graduates from US petroleum engineering schools. The SPE Manpower Committee's US surveys show that large companies will decrease their hiring while small companies and service companies will increase their hiring of engineers. During 1992--93, only about 65% of graduating petroleum engineering students were known to have jobs. Another finding is that, overall, new US SPE membership is decreasing while non-US membership is increasing.
Anderson's Personality-Trait Words: Has Their Likableness Changed?

Conolley and Maruyama (in press) present updated mean "L" values for the 555 personality-trait words origi nally scaled by Anderson (1968) in 1964. This paper pre sents general similarities and differences between the two sets of trait words and focuses on a subset of words showing the most and least change over the 10 years.
Brain pathology and neuronal losses in the living brain of Alzheimer's patients

Abstract 2-(1-{6-[(2-[F-18]Fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([F-18]FDDNP)–the first molecular imaging probe reported to be effective in the visualization of neuropathology in the living brain of Alzheimer's disease (AD) patients–labels amyloid-like aggregates (Aβ plaques and neurofibrillary tangles (NFTs)) both in vitro and in vivo. [F-18]FDDNP has proven useful in following reliably the neuropathological progression of the disease in the living brain, more specifically: (a) the distribution of [F-18]FDDNP accumulation follows known patterns of pathology deposition established from pathological determinations by Braak and Braak; (b) the degree of [F-18]FDDNP brain deposition correlates well with behavioral measures in these patients (e.g., MMSE); and (c) conversion of controls to MCI, and MCI to AD have also been reliably followed with high precision and sensitivity. These results in humans are logically paralleled with transgenic rodents, e.g., the triple Aβ transgenic rat model, recently developed by Cephalon Inc. and Xenogen Biosciences. We have also established that quantification of the resulting decreases in 5-HT 1A receptor densities with PET is excellent in vivo marker of neuronal damage, particularly the vulnerable glutamatergic pyramidal neurons in hippocampus. Using 4-[F-18]fluoro- N -{2-[1-(2-methoxyphenyl)piperazinyl]ethyl}- N -(2-pyridinyl)benzamide ([F-18]MPPF) with PET imaging we found that AD patients had receptor densities significantly decreased in both hippocampi and in dorsal raphe nucleus. A strong correlation of 5-HT 1A receptor decreases in hippocampus with worsening of clinical symptoms (MMSE scores) was also found. Decreases in 5-HT 1A receptor measures correlate with decreased glucose utilization ([F-18]FDG PET) and with increased neuropathological loads ([F-18]FDDNP PET) in several neocortical regions in the same AD subjects.
Quantitative examination of oxidized polyphenol-protein complexes.

We quantitatively examined interactions between polyphenols and proteins under oxidizing conditions, using radiolabeled 1,2,3,4,6-penta-O-galloyl-d-glucopyranose (PGG) and bovine serum albumin (BSA) as model compounds. We tested NaIO4, 2,2‘-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS•+), and 2,2‘-azobis(isobutyramidine) dihydrochloride (AAPH) as model oxidants and used sodium dodecyl sulfate to disrupt noncovalent PGG−BSA interactions after the oxidation. We used trichloroacetic acid to isolate the PGG−BSA products after oxidation for radiochemical quantitation. NaIO4 and ABTS•+ oxidized PGG−BSA complexes more rapidly than AAPH. Using NaIO4 as the oxidant, we found that soluble oxidized PGG−BSA complexes formed rapidly and were converted to insoluble complexes if PGG was present in excess over BSA. Keywords: Polyphenol; hydrolyzable tannin; radiolabeled pentagalloyl glucose; polyphenol oxidation; tannin oxidation; protein modification; oxidized tannin−protein interactions
Mexico’s ‘Commission for the Defense of the Spanish Language’ (1981-82)

This paper focuses on one of the most intriguing and short-lived corpus language planning efforts in the history of Mexican Spanish—the Comision Para La Defensa del Idioma Espanol (Commission for the Defense of the Spanish Language). Formed in 1981 and disbanded the next year, the Commission’s concentration during its short tenure was the cleansing of Mexican Spanish grammar of so-called errors as well as the Mexican Spanish lexicon of English borrowings. Those linguists who worked on the Commission were both prescriptive as well as descriptive in perspective, and hence some very valuable linguistic work resulted. This paper compares some of the Commission’s findings with the state of English borrowing in Mexican Spanish today.
Enhancing student success: Taking the classroom success seriously

Professor Vincent Tinto opens this issue of the International Journal of the First Year in Higher Education by highlighting the importance of paying attention to students' experiences in the classroom. With the classroom experience of students in the United States college system firmly in mind, Tinto draws attention to what he calls the "attributes of effective classrooms". The classroom attributes he describes, such as clear expectations, timely support, feedback on assessment, engaging pedagogies and enhancing teaching skills, though drawn from the United States experience, are universal and as such are transferrable across national boundaries and applicable to higher education educators, leaders and policy makers globally. You can assess this universality by relating Tinto's criteria to your teaching environment.
A Rollout Policy for the Vehicle Routing Problem with Stochastic Demands

The paper considers the single vehicle routing problem with stochastic demands. While most of the literature has studied the a priori solution approach, this work focuses on computing a reoptimization-type routing policy. This is obtained by sequentially improving a given a priori solution by means of a rollout algorithm. The resulting rollout policy appears to be the first computationally tractable algorithm for approximately solving the problem under the reoptimization approach. After describing the solution strategy and providing properties of the rollout policy, the policy behavior is analyzed by conducting a computational investigation. Depending on the quality of the initial solution, the rollout policy obtains 1% to 4% average improvements on the a priori approach with a reasonable computational effort.
Chaos and fractals from third-order digital filters

It is observed that the third-order digital filter with an overflow non-linearity has a much richer dynamics than the second-order digital filter. Computer simulations show that the third-order non-linear system can exhibit incredibly complicated fractal geometrical patterns. A three-dimensional trajectory of the non-linear system always lies on several parallel planes, but reaches these planes at different points to create the chaotic behaviour and the fractal geometrical patterns. the number and location of the planes are determined by the parameters of the system and the starting point of the trajectory. In general, a seven-value symbolic dynamics is developed to explain the complex dynamics observed in the non-linear digital filter.
Effects of Hibernation on Interradicular Alveolar Bone

The interradicular alveolar bones of the nonhibernating and hibernating ground squirrels were compared using laght and transmission electron microscopy. During hibernation changes occurring in the bone suggest osteocytic osteolysis. Minerals may be mobilized from bone for utilization elsewhere in the body to maintain a minimal metabolic level for surtival.
Synthesis of Derivatives of N-Methyl-2-phenylsuccinimide Involving a Lithium Salt Condensation and a Novel Application of the Mannich Reaction: Potential Anticonvulsant Agents

The preparation of several Mannich bases of N -methyl-2-phenylsuccinimide was accomplished under a variety of conditions. There is no report in the literature of the application of the Mannich reaction to N -substituted-2-arylimides. The next higher homologs of these Mannich bases were prepared by a base displacement reaction in toluene between the lithium salt of N -methyl-2-phenylsuccinimide and the appropriate β-chloroethylamine hydrochlorides. Preliminary pharmacological data are reported.
Bone morphogenetic proteins (BMPs) : how do they function and what can they offer the clinician?

Bone Morphogenetic Proteins (BMPs) form a unique group of proteins within the Transforming Growth Factor beta (TGF-beta) superfamily of genes and have pivotal roles in the regulation of bone induction, maintenance and repair. They act through an autocrine or paracrine mechanism by binding to cell surface receptors and initiating a sequence of downstream events that have effects on various cell types. Differentiation of osteoprogenitor mesenchymal cells and up-regulation of osteoblastic features occur under the influence of cytokines and growth factors that are expressed with the direct or indirect guidance of BMPs acting at the transcriptional level or higher. The Smads family of proteins has been identified as the downstream propagator of BMP signals, whereas hedgehog genes are possible modulators of BMP expression. The inflammatory response observed during wound repair and fracture healing, results in by-products that interact with BMPs and affect their biologic potential. Additive, negative or synergistic effects are observed when homodimeric or heterodimeric forms of BMPs interact with BMP receptors. Storage within the bone matrix allows for their involvement in the modeling/remodeling process by mediating coupling of osteoblasts and osteoclasts. Micro-environmental conditions, dose, possible carrier materials and geometrical parameters of delivery matrix are critical determinants of the pharmacokinetics of BMP action and the biologic outcome during wound repair. Because of their osteogenic potential, BMPs are of tremendous interest as therapeutic agents for healing fractures of bones, preventing osteoporosis, treating periodontal defects and enhancing bone formation around alloplastic materials implanted in bone.
General Strain Theory, Peer Rejection, and Delinquency/Crime:

The development of general strain theory (GST) has led to a renewed focus on the influence of negative life experiences on antisocial behavior. Although a number of studies have generated an impressive array of support for the theory, several avenues remain open for research. In this article, we examine how a specific noxious stimuli, peer rejection, relates to delinquency/crime, and the degree of shared relation among peer rejection and delinquency/crime. Using data from a national sample of 413 children and adolescents, analyses indicated two highly stable trajectories of peer rejection and three trajectories of delinquency/crime, that peer rejection and delinquency/crime were not strongly related in general, but a joint analysis of their relationship revealed that high peer rejection was related to high delinquency/crime among males but not among females. Implications and directions for future research are highlighted.
Adaptive self-tuning memory in DB2

DB2 for Linux, UNIX, and Windows Version 9.1 introduces the Self-Tuning Memory Manager (STMM), which provides adaptive self tuning of both database memory heaps and cumulative database memory allocation. This technology provides state-of-the-art memory tuning combining control theory, runtime simulation modeling, cost-benefit analysis, and operating system resource analysis. In particular, the nove use of cost-benefit analysis and control theory techniques makes STMM a breakthrough technology in database memory management. The cost-benefit analysis allows STMM to tune memory between radically different memory consumers such as compiled statement cache, sort, and buffer pools. These methods allow for the fast convergence of memory settings while also providing stability in the presence of system noise. The tuning mode has been found in numerous experiments to tune memory allocation as well as expert human administrators, including OLTP, DSS, and mixed environments. We believe this is the first known use of cost-benefit analysis and control theory in database memory tuning across heterogeneous memory consumers.
Questionably Adult: Determinants and Effects of the Juvenile Waiver Decision

Data were collected on all youth considered for transfer to adult court over a six-year period in a single jurisdiction. Demographic, legal, and organizational determinants of the waiver decision were treated as independent variables in a discriminant analysis of that decision. Analysis of covariance then was used to assess the effect of court of adjudication on severity of sentencing; the demographic, legal, and organizational variables were used as controls. Variables distinguishing fit from unfit youth were the seriousness of the offense, the number and nature of prior offenses, and prior treatment. Personal and aggravated personal offenders received more severe sentences in adult court than their counterparts in juvenile court, but property offenders were treated more leniently. Seriousness of offense played a significant role in adult court sentencing, but was over-shadowed in juvenile court by the number and nature of prior offenses and by prior treatment.
Long noncoding RNAs in C. elegans

Thousands of long noncoding RNAs (lncRNAs) have been found in vertebrate animals, a few of which have known biological roles. To better understand the genomics and features of lncRNAs in invertebrates, we used available RNA-seq, poly(A)-site, and ribosome-mapping data to identify lncRNAs of Caenorhabditis elegans. We found 170 long intervening ncRNAs (lincRNAs), which had single- or multiexonic structures that did not overlap protein-coding transcripts, and about sixty antisense lncRNAs (ancRNAs), which were complementary to protein-coding transcripts. Compared to protein-coding genes, the lncRNA genes tended to be expressed in a stage-dependent manner. Approximately 25% of the newly identified lincRNAs showed little signal for sequence conservation and mapped antisense to clusters of endogenous siRNAs, as would be expected if they serve as templates and targets for these siRNAs. The other 75% tended to be more conserved and included lincRNAs with intriguing expression and sequence features associating them with processes such as dauer formation, male identity, sperm formation, and interaction with sperm-specific mRNAs. Our study provides a glimpse into the lncRNA content of a nonvertebrate animal and a resource for future studies of lncRNA function.
Tracking mammoths and mastodons: Reconstruction of migratory behavior using strontium isotope ratios

Variations in the strontium isotope ratio ( 87 Sr/ 86 Sr) of tooth enamel are used to examine the migration patterns of late Pleistocene mammoths and mastodons from Florida. An animal’s 87 Sr/ 86 Sr ratio tracks the ratios of its environment, which vary with differences in bedrock and soil. Consequently, the environmentally controlled differences in 87 Sr/ 86 Sr ratio recorded in mineralized tissue, such as tooth enamel, may be used to reconstruct the movement patterns of an individual. We map variations in local 87 Sr/ 86 Sr ratios across modern Florida and Georgia through analysis of rodent teeth, plants, and surface water, then use this map to interpret the movement patterns of extinct mammals. Mastodons from northern and central Florida have higher 87 Sr/ 86 Sr ratios than both modern environmental samples from Florida and fossils from nonmigratory species, suggesting that mastodons migrated north into Georgia. Mammoths display ratios similar to those of environmental samples and resident species, suggesting that they did not migrate outside Florida.
The Kinetics of Dissolution of Tooth Enamel — A Constant Composition Study

The kinetics of dissolution of powdered bovine enamel and of human enamel, both untreated and extracted with either hypochlorite or chloroform, has been studied using a constant solution composition technique in undersaturated solutions of calcium phosphate (total molar calcium concentration, TCa = 0.3 to 13.1 × 10-3 mol L-1, total molar phosphate, Tp = 0.18 to 7.9 x 10-3 mol L-1) at an ionic strength of 0.15 mol L-1, and pH = 4.5. The kinetic equations describing the dissolution reactions suggest a surface dislocation mechanism, and the presence of fluoride ion markedly retarded the reaction. For human enamel, a fluoride level of only 0.5 ppm reduced the rate of dissolution ten-fold. In contrast, the dissolution of hydroxyapatite, HAP, is best interpreted in terms of a polynucleation process.
Varied flow in open channels with adverse slope

This paper, to be published elsewhere, was presented in preliminary form for the author by Dr. B. A. Bakhmeteff.
Prediction of Swelling Potential for Compacted Clays

The possibility of damage to structures due to the swelling of clays is complicated by the problem of identifying, at the outset of an investigation, those soils likely to possess undesirable expan...
The metal-organic chemical vapor deposition growth and properties of InAsSb mid-infrared (3-6-/spl mu/m) lasers and LEDs

We describe the metal-organic chemical vapor deposition (MOCVD) growth of AlAs/sub 1-x/Sb/sub x/ cladding layers and InAsSb-InAs multiple-quantum well (MQW) and InAsSb-InAsP strained-layer superlattice (SLS) active regions for use in mid-infrared emitters. The AlAs/sub 1-x/Sb/sub x/ cladding layers were successfully doped p- or n-type using diethylzinc or tetraethyltin, respectively. By changing the layer thickness and composition of SLSs and MQWs, we have prepared structures with low temperature (<20 K) photoluminescence wavelengths ranging from 3.2 to 6.0 /spl mu/m. We have made gain-guided injection lasers using undoped p-type AlAs/sub 0.16/Sb/sub 0.84/ for optical confinement and both strained InAsSb-InAs MQW and InAsSb-InAsP SLS active regions. The lasers and light emitting diodes (LEDs) utilize the semi-metal properties of a GaAsSb(p)-InAs(n) heterojunction as a source for electrons injected into active regions. A multiple-stage LED utilizing this semi-metal injection scheme is reported. Gain-guided, injected lasers with a strained InAsSb-InAs MQW active region operated up to 210 K in pulsed mode with an emission wavelength of 3.8-3.9 /spl mu/m and a characteristic temperature of 29-40 K. We also present results for both optically pumped and injection lasers with InAsSb-InAsP SLS active regions. The maximum operating temperature of an optically pumped 3.7-/spl mu/m strained-layer superlattice (SLS) laser was 240 K. An SLS LED emitted at 4.0 /spl mu/m with 80 /spl mu/W of power at 300 K.
The role of polymer matrix structure and interparticle interactions in diffusion-limited drug release

A lattice random-walk model is used to simulate diffusion in a porous polymer. This model may be useful for the practical design of drug-release systems. Both interacting and noninteracting particles (random walkers) were allowed to diffuse through a pore with a single exit hole. It was found that the specific interactions among the diffusing particles have little influence on the overall release rate. Diffusion through more complicated structures was investigated by simulating the diffusion of particles through two pores connected by a constricted channel whose length and width were varied. The overall rate of release was found to be proportional to the width of the constricted channel. When the length of the channel was greater than or equal to the length of the pore, the rate of release was also inversely proportional to the channel length. From a practical standpoint, release rates can be decreased (and times for release increased) by one or two orders of magnitude by decreasing the width and expanding the length of the interconnecting channels in the polymer matrix.
Who Majors in Psychology

We compared 36.5 graduates with bachelor's degrees in psychology to 244 in sociology/anthropology, 194 in speech communication, 155 in physical and health education, and 204 in social work/society and justice on earlier high school interests, grades, and achievement measures (e.g., vocabulary test scores). Advisers can inform prospective majors that, as high school students, psychology graduates' strongest vocational interest areas were artistic, general cultural, scientific, and service, not unlike successful PhDs in psychology. Psychology majors had similar interests to those majoring in the other four areas, but our majors had better high school grades and achievement test scores.
Who's not afraid of Proposal B? An analysis of exit-poll data from Michigan's vote on physician-assisted suicide

In November 1998, Michigan voters rejected Proposal B, a citizen initiative that would have legalized physician-assisted suicide (PAS). Although polls had long indicated overwhelming support for PAS, support for Proposal B declined before the election. We analyzed exit-poll data to characterize opponents, supporters, and cross-over voters. We then compared our results with those from earlier research that examined attitudinal and socio-demographic influences. We found that many presumptive PAS supporters did not vote for Proposal B. These data may call into question prospects for similar initiatives.
Nutritional Status and Nutrient Intake Challenges in Children With Spinal Muscular Atrophy.

Abstract Background Nutrition is recognized as a core component of multidisciplinary care for patients with spinal muscular atrophy, but specific nutritional challenges in this population are not well described. We aimed to describe the nutritional status and nutrient intake in children with spinal muscular atrophy. Methods We performed a retrospective medical record review of prospectively collected data from children with spinal muscular atrophy followed at a multidisciplinary clinic at a tertiary referral center. We collected data including clinical parameters; anthropometrics, including weight, height, and body mass index (BMI); and 24-hour dietary intake records in all children followed in the clinic. Available data were found in records from the dietitian as part of a standard evaluation process, and additional clinical data were acquired from patient medical records. Subjects were classified based on spinal muscular atrophy type, and nutritional intake data were compared with dietary reference intakes for gender and age. Z -scores were calculated for weight for age (WAZ), height for age, and BMI (BMIZ) using the World Health Organization AnthroPlus software with appropriate World Health Organization reference growth standards. Subjects were classified as malnourished if their WAZ was +2. Anthropometric measurements were obtained at first visit and at a follow-up visit at an average of a 3-year interval between the clinic visits. A decline of more than 0.5 WAZ over this period was defined a priori as significant nutritional deterioration. Results We analyzed data from 60 subjects, 26 (43%) female, with median age 5.5 years (interquartile range 2 years to 12 years). The cohort consisted of children with spinal muscular atrophy type 1 (28 %), type 2 (45 %), and type 3 (27 %). At the first clinic visit, nine (15%) patients were malnourished. Thirteen (23%) subjects had a significant decline in WAZ from −0.35 (−1.31 to 0.58) to −1.04 (−2.15 to 0.02) at follow-up after approximately 3 years. A third of these subjects were already malnourished at first visit. A significant decline in BMIZ was noted in 47% of the cohort, and the prevalence of severe malnutrition (BMIZ Conclusions Malnutrition was prevalent in children with spinal muscular atrophy, and nearly half the cohort demonstrated nutritional deterioration over time. Energy, protein, and vitamin D intakes were inadequate in a majority of the cohort. Underfeeding was highly prevalent, but overfeeding was also present in a third of the enterally fed cohort. Future studies describing optimal nutrient requirements and body composition variables in this group are required.
Does It Take an Engraved Invitation for Taxpayers to Adopt IPIC-LIFO?

Seago analyzes the recently issued inventory price index computation (IPIC) regulations, which are applied to compute the cost of dollar-value LIFO inventories. He demonstrates that the congressional intent of section 472(f) was to make LIFO more accessible, especially for small businesses, the original regulations generally were not "user friendly" and thus the IPIC method was not widely used. Now, 20 years later, the Service has addressed many of the problems encountered and has issued vastly improved regulations. He concludes that the IPIC method should become widely used, replacing the internal index methods in many cases, and leading to more taxpayers adopting LIFO.
Reply to Comments on: 'Fraud Detection: The Effect of Client Integrity and Competence and Auditor Cognitive Style'

I appreciate the comments and suggestions of my two discussants and many other individuals who attended the symposium. These discussions provided thoughtful insights for additional analysis and extensions to the original research. My response to the discussants' comments will be to expand the rationale for using locus of control and to discuss the client integrity and competence manipulation. I will also show how the results obtained from the further analysis suggest other reasons for seniors' insensitivity to the client integrity and competence.
Application of Epoxy Resins in Tunnel Lining Concrete Repair

Concrete lining in a large diameter tunnel spillway damaged by cavitation erosion caused by variable high flows up to 20,000 cfs was repaired by use of bonded concrete, and epoxy bonded epoxy mortar. Epoxy bonded epoxy mortar was used to make the repairs except in the damaged areas of large volume. The repair area to receive epoxy mortar was prepared by bushhammering, chipping, or sandblasting. The surfaces of the concrete were made completely dry. Seeping hairline cracks were rendered dry by chemical grouting. Air and concrete temperature was maintained at about 60° F by a heating system. A clear epoxy bond coat was applied to a small area of prepared concrete surface. Epoxy mortar was applied to the bond coat while the bond coat was in a fluid to tacky condition. Curing and post curing of the epoxy mortar by use of propane infrared heaters and heat lamps were required. Painting of the cured mortar with an epoxy phenolic paint was specified.
Disseminated Mycobacterium Avium-intracellulare Infection in Homosexual Men with Acquired Cell-mediated Immunodeficiency: A Histologic and Immunologic Study of Two Cases

Disseminated Mycobacterium avium-intracellulare infections were found at autopsy in two homosexual men in whom acquired cell-mediated immunodeficiencies and marked decreases in the subpopulation of lymphocytes expressing the T-helper phenotype were well-studied. The histologic manifestations were similar to those found in lepromatous leprosy, also known to be associated with cell-mediated immunodeficiency. Possible correlations between the cellular immunodeficiency in our patients and an increased susceptibility to Mycobacterium avium-intracellulare infection as well as the unusual histologic manifestation of the mycobacterial infection are examined.
Malakoplakia. Two unusual cases which presented diagnostic problems.

Two unusual cases of malakoplakia are presented. Both cases occurred outside the urinary tract (retroperitoncum and anus) and were diagnostic problems due to the paucity of Michaelis-Guttman bodies. One case mimicked a retroperitoncal malignant fibrous histiocytoma and the other a common perianal abcess.
QOL-03OVERALL SURVIVAL AND HEALTH-RELATED QUALITY OF LIFE IN RECURRENT GLIOBLASTOMA PATIENTS RECEIVING INTRA-ARTERIAL CARBOPLATIN AFTER STANDARD CARE

INTRODUCTION: Prognosis for glioblastoma (GBM) remains dire with a reported median survival of 14.6 months. Various aggressive treatment regimens have been pursued, in certain instances with a negative impact on Heath-Related Quality of Life (HR-QOL), with modest survival benefits. In this prospective study, we describe our experience in patient reported HR-QOL and survival benefit of an intra-arterial (IA) carboplatin-based treatment for recurrent GBM in combination with other cytotoxic agents. METHODS: Adult patients with recurrent GBM treated with 400 mg/m2 IA carboplatin every 4 weeks were enrolled in this study. Additionally, patients received (a)10 mg/kg bevacizumab every 2 weeks or (b) 660 mg/m2 cyclophosphamide and 400 mg/m2 etoposide every 4 weeks. HR-QOL was measured specific time-points with EORTC QLQ-30 & BN-20 questionnaires. HR-QOL scores of 7 selected domains expected to be most affected in GBM patients were studied. Patients were followed for treatment-related adverse events and overall survival. RESULTS: The study cohort comprised of 24 patients with a median age of 49.5 years. The most prevalent neurological complications reported were headaches (n = 10) and focal seizures (n = 5). A majority of the patients (n = 14) reported nausea and fatigue. Groin hematoma at catheter insertion site was noted in 4 patients and visual deficit in 5 patients. Grade 4 thrombocytopenia was observed in 4 patients and 3 patients had strokes. Longitudinal global-QOL scores were maintained or improved in a majority of patients, prior to disease progression. For this cohort, median overall survival was 25 months (range, 16-30) with 6 surviving patients at the end of the follow-up period. CONCLUSION: IA chemotherapy with carboplatin is a relatively safe and well tolerated treatment in recurrent GBM demonstrating encouraging outcomes in terms of overall survival in a selected group of patients. In addition, there were no significant unfavorable effects on HRQOL scores noted in the 7 preselected domains.
Low expression of the GILZ may contribute to adipose inflammation and altered adipokine production in human obesity

The glucocorticoid-induced leucine zipper (GILZ), a primary target of glucocorticoids, is expressed in human adipocytes, but its importance in adipocyte function is unknown. Because TNFα is increased in obese adipose tissue and antagonizes a number of glucocorticoid actions, we investigated the interplay of these pathways. GILZ knockdown increased and GILZ overexpression decreased interleukin-6 (IL-6) and leptin mRNA and protein secretion. GILZ knockdown increased the magnitude of the glucocorticoid effect on leptin secretion, but did not affect the glucocorticoid suppression of IL-6. Although GILZ silencing decreased adiponectin mRNA levels, it did not affect the amount of adiponectin secreted. GILZ negatively modulated pro-inflammatory signaling pathways, blocking basal and TNFα-stimulated (1 h) p65 nuclear factor κB nuclear translocation and transcriptional activity by binding to p65 in the cytoplasm. GILZ silencing increased basal ERK1/2 and JNK phosphorylation, and decreased MAPK phosphatase-1 protein levels. Longer term TNFα (4 h or 24 h) treatment decreased GILZ expression in human adipocytes. Furthermore, adipose tissue GILZ mRNA levels were reduced in proportion to the degree of obesity and expression of inflammatory markers. Overall, these results suggest that GILZ antagonizes the pro-inflammatory effects of TNFα in human adipocytes, and its downregulation in obesity may contribute to adipose inflammation and dysregulated adipokine production, and thereby systemic metabolism.
MICROSTRUCTURE ANALYSIS OF SURFACING WELDING LAYER OF CEMENTED CARBIDE ON THREE CONE BIT

In this paper, we studied the quenching and cryogenic treatment processes of WC - Co and founding tungsten carbide cemented carbide, and analyzed their microstructure and the cause of increased performance of these treatment as well as the mechanism of increased performance of these treatment. It is conformed that the microstructure of WC - Co cemented carbide is γ′ and M 7C 3, M 6C, W 23 C 6 carbide and founding tungsten carbide is η and M 7C 3, M 6C, M 23 C 6. The adhesive phase can be strengthened and the histology and the microstructure can be improved by quenching and cryogenic treatment.
Mathematical Oncology: Using Mathematics to Enable Cancer Discoveries

AbstractMathematical and computational modeling approaches have been applied to every aspect of tumor growth from mutation acquisition and tumorigenesis to metastasis and treatment response. In thi...
Using an Automatically Generated Dictionary and a Classifier to Identify a Person's Profession in Tweets.

Algorithms for classifying pre-tagged person entities in tweets into one of 8 profession categories are presented. A classifier using a semi-supervised learning algorithm that takes into consideration the local context surrounding the entity in the tweet, hash tag information, and topic signature scores is described. A method that uses data from the Web to dynamically create a reference file called a person dictionary, which contains person/profession relationships, is described, as is an algorithm to use the dictionary to assign a person into one of the 8 profession categories. Results show that classifications made with the automated person dictionary compare favorably to classifications made using a manually compiled dictionary. Results also show that classifications made using either the dictionary or the classifier are moderately successful and that a hybrid method using both offers significant improvement.
Regulating the Empirical in Practical Theology

Through the exploration of youth ministry scholarship this article explores the empirical movement in practical theology. The article argues that while the empirical turn has helped practical theology better attend to the lived and concrete experience of human beings, it has also made the theological more difficult. Therefore, the first part of the article reminds the reader of how the empirical method brings distinct, and at times foreign, epistemologies into contact with the theological task. Reviewing this point, this article draws it deeper by turning to Charles Taylor, showing how the empirical methods obscure transcendence in favor of immanence. The article then constructs an approach to the empirical that might open the field to transcendence and avoid reduction. It argues for ministry itself being the motivation and shape of empirical work in practical theology, showing how ministry mediates divine action, while upholding the importance and particularities of human action.
Dopamine Receptor Gene DRD4 7-Repeat Allele X Maternal Sensitivity Interaction on Child Externalizing Behavior Problems: Independent Replication of Effects at 18 Months

The DRD4 VNTR has been associated with child behavior problems in interaction with maternal insensitivity in European and American cohorts of preschoolers, with the 7-repeat (7R) allele associated with greater problems. We sought to replicate and expand these findings by examining effects on reports of child behavior problems at 18 months. A 63 family sample with data for observed maternal sensitivity ratings, DRD4 VNTR genotype, and maternal report of child behavior problems at 18-months was used in this preliminary analysis. Maternal sensitivity was measured at 6-months of age using laboratory observational measures (free-play and a teaching task). Maternal report of toddler behavior was obtained at 18-months via the standard Child Behavior Checklist, and infant genotype on the DRD4 VNTR was obtained using PCR. Infants carrying the DRD4 7R allele showed greater effects of maternal insensitivity than non-carriers for behavioral problems at 18-months. We replicated previous findings of association of infant DRD4 x maternal sensitivity interactions with child Externalizing problems in the European-ancestry sample (N = 42) in a median split of maternal sensitivity (p = .00011, eta2 = .329) and in regression analyses controlling for maternal age, maternal depression, and child gender in European ancestry (B = -3.4, SE 1.33, p = .01) and the total sample (B = -2.2, SE 1.02, p = .02). Exploratory analyses also found evidence of DRD4 x maternal sensitivity interaction with the CBCL ADHD scale. These findings replicate in an independent cohort DRD4 x maternal insensitivity interaction effect on child externalizing behavior problems at 18 months, further supporting the role of the DRD4 genotype in differential sensitivity to parenting.
Natural Convection Film Boiling on a Sphere

Immersing a solid into a liquid produces film boiling if the surface temperature is above the Leidenfrost point, Aside from cryogenic applications, metallurgists have tested the cooling abilities of liquids by dropping a hot sphere or other bodies into a liquid bath [1]. The boundary layer type of film boiling can be easily analyzed for steady state conditions if the film is laminar. This analysis also may be applied to a transient test if the change in enthalpy of the vapor film is much smaller than that of the solid, as it is in the tests described later. Therefore when “slow” cooling takes place with respect to the vapor film, quasi-stationary film boiling may be assumed to occur and be so described analytically. An analysis is presented in which a diffusion approximation is made by linearizing the governing equations. The approximate result serves as a guide to a generalized correlation of film boiling heat transfer data.
Hydraulic Fracturing and Its Potential Impact on Shallow Groundwater

Unconventional natural gas extraction from impermeable geologic formations is getting momentum in recent years due to advances in horizontal drilling and hydraulic fracturing. By 2040, shale resources are projected to account for 53 % of all natural gas production in the U.S. However, the development of unconventional oil/gas production from hydraulic fracturing has raised serious concerns about its potential impact on the quantity and quality of water resources and the environment due to the large volume of water needed and the use of toxic substances in hydraulic fracturing fluids. This paper gives an overview of the hydraulic fracturing used to extract shale gas, its potential impact on water resources, provides an overview of modeling studies and tools used to assess its potential impacts, and regulation issues related to it. The most significant risks resulting from hydraulic fracturing and shale gas development are (1) the excessive withdrawal of water, (2) gas migration and groundwater contamination due to faulty well construction, blowouts, (3) contamination by wastewater disposal, and (4) accidental leaks and spill of wastewater and chemicals used during drilling and hydraulic fracturing process.
Peer Prediction with Heterogeneous Users

Peer prediction mechanisms incentivize agents to truthfully report their signals, in the absence of a verification mechanism, by comparing their reports with those of their peers. Prior work in this area is essentially restricted to the case of homogeneous agents, whose signal distributions are identical. This is limiting in many domains, where we would expect agents to differ in taste, judgment, and reliability. Although the Correlated Agreement (CA) mechanism [Shnayder et al. 2016a] can be extended to handle heterogeneous agents, there is a new challenge of efficiently estimating agent signal types. We solve this problem by clustering agents based on their reporting behavior, proposing a mechanism that works with clusters of agents, and designing algorithms that learn such a clustering. In this way, we also connect peer prediction with the Dawid and Skene [1979] literature on latent types. We retain the robustness against coordinated misreports of the CA mechanism, achieving an approximate incentive guarantee of e-informed truthfulness. We show on real data that this incentive approximation is reasonable in practice, even with a small number of clusters.
Cinema africano: perturbando a ordem (cinemática mundial)

Kenneth Harrow proposes to situate that new formulation of the world cinema—“transnational” or “global-local”—, in relationship to those African cinemas that are both continuing in the directions undertaken with the ascension of Third Cinema and national liberation (from Ousmane Sembene to Jean-Marie Teno), to the experimental, avant-gardist approaches of Jean-Pierre Bekolo, Mahamat-Saleh Haroun and Andy Amadi Okoroafor, and the populist cinemas of the video film industries, most notably Nollywood. The paradigms evoked by Krings and Okome (2013), and by Diawara (2010), provide an opening to the central question of how the range of filmmaking practices in Africa today, from serious Independent films to Nollywood style mini-industries, requires a reconceptualization of the new transnational notions of globalization (DUROVICOVA & NEWMAN, 2010). The article carries further the work initiated earlier by the author (HARROW, 2012), emphasizing the necessity to formulate a perspective on African films grounded in systems of value that function “isomorphically.” Normative values to be destabilized by the introduction of African films to their corpus, will be those underlying “World Cinema.”
Systematic review of the potential role of cannabinoids as antiproliferative agents for urological cancers

Introduction: The palliative effects of cannabis sativa (marijuana), which include appetite stimulation, attenuation of nausea and emesis, and pain relief, are well known. The active components of cannabis sativa (cannabinoids) and their derivatives have received growing interest due to their diverse pharmacological activities, such as cell growth inhibition and tumour regression. The aim of this review is to look at the current evidence on the antiproliferative effects of cannabinoids in urological malignancies, including renal, prostate, bladder, and testicular cancers. Methods: We conducted a systematic review of studies exploring the effect of cannabinoids on tumour activity, including all study types except expert opinions. A formal search was run on Medline database from 1946 to September 2016, along with a hand-search on PubMed for relevant studies. Results: The search yielded a total of 93 studies from Medline and PubMed, of which 23 studies were included in the final analysis. To date, there are various in vitro studies elucidating the potential mechanism of action of cannabinoids for urological cancers, along with population-based studies specifically for testicular malignancies. To date, no clinical trials have been conducted for urological cancer patients. Conclusions: These results demonstrate that the role of endocannabinoids for urological malignancies is an area of active research. Further research is required not only to evaluate the crosstalk between cancer signaling pathways and cannabinoids, but also large randomized clinical studies with urological patients need to be conducted before cannabinoids can be introduced as potential therapeutic options for urological neoplasms.