cssi/SciSciGPT-SciSciNet huggingface dataset:
Cognitive-behavioral therapy augmentation of SSRI reduces cortisol levels in older adults with generalized anxiety disorder: A randomized clinical trial.

Objectives Elevated cortisol in stress and aging, such as has been seen in late-life anxiety disorders, is postulated to accelerate cognitive and physiological decline in this large and increasing population. Selective serotonin-reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT) are both effective treatments for generalized anxiety disorder (GAD) in older adults. On the other hand, there is very little research examining the effect of combining these therapies on peak cortisol levels. For the current analyses, we examined the effectiveness of CBT augmentation on peak cortisol levels in older adults diagnosed with GAD. Methods The sample consisted of 42 individuals with late-life GAD who received an acute course of the SSRI escitalopram and then entered a 16-week randomized phase. Twenty-one participants were randomized to receive 16 sessions of CBT in addition to continuing escitalopram and the remaining 21 participants continued on escitalopram without CBT. Generalized estimating equations were performed to assess the effectiveness of CBT augmentation on peak cortisol levels (30 min after waking). Results Older adults with GAD who received both escitalopram and CBT demonstrated a significant reduction in peak cortisol levels at posttreatment compared to the group who received escitalopram without CBT augmentation. Conclusions CBT augmentation of SSRI treatment reduced peak cortisol levels for older adults with GAD. Since persistently high cortisol levels in aging are thought to increase age-related cognitive and medical problems, our findings suggest that there may be a benefit to health and cognition of CBT augmentation for late-life anxiety disorders.
Religious Affiliation and Manifest Hostility

To determine the relationship among hostility, guilt, and religion, 167 subjects from introductory psychology courses were given the Buss-Durkee Hostility Inventory and a questionnaire establishing religious affiliation. Analysis indicated that Catholics expressed more verbal hostility than Protestants. Moreover, Catholic men were more resentful than Catholic women and exhibited greater indirect hostility and suspicion than Protestant men.
Hot Electrons in Plasmonic Devices: Internal Photoemission and Quantum Limitations

Hot-electrons in plasmonic devices offer an alternative route to overcome the bandgap limitations of semiconductors. However, experimentally recorded efficiencies are extremely low. We developed a bottom-up approach, and introduced high efficiency photoemission devices.
Virtual instrumentation based measuring system of turbogenerator torsional vibration

A framework of data acquisition system is designed via virtual instrumentation technology,based on which a test system is developed to effectively measure and analyze the torsional vibration of turbogenerator.The PXI system is adopted to configure its system hardware and its system software is programmed with LabVIEW language.The speed signal of turbogenerator is recorded and its torsional vibration components are directly extracted by the zero-phase digital filter.Each torsional vibration mode is separated and its corresponding characteristics are analyzed.The analysis of test data from site applications shows that the system is flexible and applicable.
A study on immunologic response at different periods with different hepatitis B vaccine in infants

Objective To know the immunologic response at different periods with different hepatitis B vaccine( Hep B) in infants. Methods From July 1 to December 31 in 2009,the local infants born from hepatitis B virus( HBV) surface antigen( HBs Ag) negative mother in Ninghai were selected and received a 0. 5 ml of 5- μg Hep B made by recombinant deoxyribonucleic acid( DNA) techniques in saccharomyces cerevisiae yeast( Hep B- SCY) and those in Yuyao were selected and received a 0. 5 ml of 10- μg Hep B made by recombinant DNA techniques in hansenula polymorpha yeast( Hep B- HPY) with a 0- 1- 6 month schedule. The specimens of blood were collected at 7 months,12 months and 18 months after vaccination for testing antibody. Results At 7 months,12 months and 18 months after vaccination,the geometric mean concentration( GMC) of Anti- HBs in Hep B- SCY group were 714. 79 ± 3. 50 m IU / m L,259. 89 ±3. 87 m IU / m L and 78. 38 ± 4. 04 m IU / m L,respectively. While in Hep B- HPY group were 2 420. 76 ± 3. 51 m IU / m L,703. 55 ± 3. 46 m IU / m L and 171. 32 ± 3. 76 m IU / m L,respectively. There was statistical significant difference of GMC between Hep B- SCY group and Hep B- HPY group( P 0. 01). The percent of antibody 100 m IU / m L in Hep B- SCY group were 6. 39%,23. 33% and 55. 42%,and in Hep B- HPY group,were 2. 17%,5. 17% and 31. 95%,respectively.The difference between Hep B- SCY group and Hep B- HPY group had significantly statistical significance( P 0. 01).Conclusion The immunologic response at different periods of Hep B- HPY was better than that of Hep B- SCY.
Surgical Treatment of Hands for C5-C6 Tetraplegia

Summary The patient with C5–C6 tetraplegia who has powerful wrist extensors and median sensibility has the potential for a remarkably functional hand of excellent aesthetic qualities and powerful independent pinch and grasp capabilities. A three-stage reconstruction is described that gives maximum utilization to the remaining four functioning muscles. The procedure is technically difficult and should be undertaken only by the experienced hand surgeon for carefully selected patients for whom the benefit can fully warrant the efforts. Triceps substitution by a posterior deltoid transfer is an excellent adjunctive procedure.
A LEGO-based Approach to Introducing Test-Driven Development

Test-driven development (TDD) is an important software engineering technique that requires writing tests before writing the code to be tested. We describe an approach to introduce the main ideas and practices of TDD using an engaging hands-on activity where students write test cases and construct testable tangible objects with LEGO bricks.
Exploring Self-Brand Connection in The Social Media Context: The Case of Twitter

This paper explores the role of self-brand connection of Twitter users with the Twitter brand in determining both their loyalty to Twitter and their behaviors and attitudes to the businesses they follow on Twitter. We also test the proposition that perceived self- Twitter personality match is instrumental in strengthening self-brand connection for its users.
Cross-Sectional Lamé Mode contiguous filters for next-generation LTE-advanced platforms

This work discusses, a new class of Aluminum Nitride (AlN)-based filters and duplexers for operation in the microwave frequency range. These novel devices are based on the use of recently developed Cross-Sectional-Lame-Mode resonators (CLMRs), thus enabling a wideband operation (Bandwidth (BW) >20 MHz around 1 GHz) thanks to their high electromechanical coupling coefficient (kt2 > 6%). In addition, as the resonance frequency of CLMRs can be defined lithographically, CLMRs enable the monolithic integration of multiple contiguous or non-contiguous filters to be used for carrier-aggregation in next-generation LTE-A platforms. Furthermore, a novel device architecture enabling reconfigurability of AlN-based resonators is also presented. This is based on the use of Phase Change Material (PCM) switches monolithically integrated with AlN piezoelectric micro-acoustic resonators. We experimentally demonstrate that this novel reconfiguration strategy enables the dynamic control of the key-features of AlN-based filters (center-frequency, BW, input impedance and roll-off) without significantly increasing the complexity of the device fabrication process and substantially degrading the device performance.
Tectonic tremor along the northern Hikurangi Margin, New Zealand, between 2010 and 2015

We present the first comprehensive tectonic tremor catalog for the northern Hikurangi Margin obtained from the systematic analysis of data from the New Zealand Seismic Network between 2010 and 2015. The recent densification of this array along the northern Hikurangi Margin has allowed for the detection and location of tectonic tremor associated with 20 out of 26 identified transients in the continuous GPS record along the east coast of the Raukumara Peninsula. Eighteen of these transients have never been reported in the literature and are likely to be slow slip events with magnitudes smaller than those previously studied. We also investigate the spatiotemporal relationships between shallow, offshore slow slip, tectonic tremor, and earthquakes for the duration of the study period.
Middle ear barotrauma causing transient facial nerve paralysis after scuba diving.

Middle ear barotrauma is a well known entity with typical injury occurring when diving or ascending in a commercial jetliner. Patients often present with symptoms of acute onset otalgia, hearing loss and sometimes haemotympanum (with or without tympanic membrane perforation). On rare occasions, facial nerve paralysis can occur when the tympanic segment of the facial nerve is dehiscent within the middle ear. We present a case of spontaneously resolving facial nerve palsy associated with middle ear barotrauma following a brief, shallow dive. Prompt and astute diagnosis leads to proper management with simple myringotomy and can prevent unnecessary testing and other misguided treatments. Language: en
Integrin Dynamics and Stages of Memory Formation

There has been a great deal of controversy about the idea, which dates to the 19th century, that newly formed memories become progressively more stable with time. This chapter considers several of the more prominent arguments from the perspective of synaptic modifications (long-term potentiation, LTP) that are intimately linked to memory encoding. The discussion includes consideration of novel LTP phenomenology and underlying cell biological mechanisms. LTP has both rapid and delayed consolidation periods that depend on synaptic adhesion receptors belonging to the integrin family. Analysis of these phases provides explanations for salient features of memory stabilization and supports an uncomplicated version of memory consolidation theory.
Clinical Applications and Regulatory Issues for Physician-Modified Endovascular Grafts (PMEGs)

Physician-modified endovascular grafts have been applied to a number of clinical situations for the treatment of complex aortic disease. The routine use of such devices requires approval for an investigational device exemption from the US Food and Drug Administration. This mandate is intended to ensure patient safety and to encourage innovations in treatment that are evidenced-based. The data obtained from patients treated within an investigational device exemption clinical trial will guide the process of determining the most appropriate clinical applications for physician-modified endovascular graft techniques.
Lightweight predicate extraction for patient-level cancer information and ontology development.

Knowledge engineering for ontological knowledgebases is resource and time intensive. To alleviate these issues, especially for novices, automated tools from the natural language domain can assist in the development process of ontologies. We focus towards the development of ontologies for the public health domain and use patient-centric sources from MedlinePlus related to HPV-causing cancers. This paper demonstrates the use of a lightweight open information extraction (OIE) tool to derive accurate knowledge triples that can lead to the seeding of an ontological knowledgebase. We developed a custom application, which interfaced with an information extraction software library, to help facilitate the tasks towards producing knowledge triples from textual sources. The results of our efforts generated accurate extractions ranging from 80–89% precision. These triples can later be transformed to OWL/RDF representation for our planned ontological knowledgebase. OIE delivers an effective and accessible method towards the development ontologies.
The Value of Compressed‐Air Energy Storage for Enhancing Variable‐Renewable‐Energy Integration: The Case of Ireland

Mixed integer programming (MIP) was used to formulate a unit commitment and economic dispatch (UCED) algorithm that included two models for simulating the dynamic performance of compressed-air energy storage (CAES) units. The first model assumes CAES operating with fixed efficiencies (FEs) on both the compression and expansion side, similar to models commonly used in industry and academia. The second model is a detailed thermoeconomic (TE) model, which uses power curves obtained by CAES manufacturers to model the effect of cavern pressure on operation limits of both the compressor and expander. The UCED and CAES models were combined to identify the contribution of CAES on minimizing the impacts of wind integration into the Irish power sector in 2020. The results of the UCED-TE model show that the addition of a CAES unit in the North Ireland grid can reduce wind curtailment, CO2 emissions, and system costs. The cost reductions result mainly from reductions in wind curtailment and coal-fired generation. The FE model shows much higher reductions of wind curtailment, CO2 emissions, and total system costs. However, both models show that the benefit of CAES on the system increases with variable renewable energy and CAES installed capacity. The difference in the results of the two models is reduced in scenarios of high CAES capacity. The main conclusions of the study are that existing fixed-efficiencies CAES models overestimate reductions on wind curtailment whereas both models show the system-wide economic benefits of CAES grow considerably as wind production grows.
T2 vertebrectomy with combined anterior and posterior arthrodesis for treatment of a solitary plasmacytoma.

BACKGROUND Plasma cell neoplasmas are a heterogenous group of neoplastic tumor lesions occurring secondary to disordered proliferation of cells from a monocyte lineage. Plasmacytoma is a rare lesion that accounts for 5% of all plasma cell neoplasms. The current recommended treatment for solitary plasmacytoma is moderate dose radiation therapy. For patients who are suffering from axial back pain, spinal instability, radiculopathy, or bowel/bladder dysfunction secondary to spinal cord compression, surgical intervention with spinal decompression and stabilization can be used as an adjuvant to radiation therapy. CASE DESCRIPTION We report a patient who presented with worsening axial and bilateral upper extremity pain. He was found to have a locally aggressive tumor involving the vertebral body of T2. After a repeat magnetic resonance imaging (MRI) and a computed tomography (CT)-guided biopsy, the diagnosis of a solitary plasmacytoma was confirmed. It destroyed over 90% of the T2 vertebral body, resulted in 22° of local kyphosis, and caused spinal cord compression. The tumor was treated with a T2 vertebrectomy, posterior arthrodesis from C5-T4, and anterior arthrodesis from T1-3. CONCLUSIONS Solitary plasmacytomas of the vertebral bodies are difficult lesions to treat secondary to their location and risk of neurologic compromise. Surgical intervention with tumor resection and adjuvant chemotherapy or radiation is the recommended treatment option.
Developing Faculty to Provide University Students with Improved Learning Experiences: The Role of Centers for Teaching and Learning

The article addresses the importance of incorporating faculty development as a key priority of higher education institutions. A literature review and some face-to-face and online interviews were conducted at various U.S. institutions, to identify common and best practices regarding this important matter. The article offers some ideas about what is done, and how it is done, to help faculty be ready for the challenging role they need to play: to be effective developers of a diverse student body that meets the evolving needs of industry and that utilizes technological tools that never existed before.
Real-time adaptive LDPC coded APSK for aeronautical telemetry

In this paper, we consider the design of capacity-approaching forward error correction (FEC) coded amplitude phase shift keying (APSK) modulation schemes for use in the aeronautical telemetry. By maximizing the mutual information, we first investigate the designs of APSK modulations suitable for communication over nonlinear wireless channels. Then we propose a unified FPGA-based hardware-efficient architecture which combines the capacity-approaching LDPC decoders with four APSK modulation formats, including Gray-mapping-based 8-APSK, 16-APSK, 32-APSK, and 64-APSK. The proposed architecture allows the flexibility of the FEC-encoded signal to be received by legacy test-range systems. The emulation results show that such an LDPC-coded modulation scheme can adapt to wide range of received signal-to-noise ratios, ranging from 9.4 dB to 21.4 dB, by using different LDPC codes and/or modulation formats.
Indirect effects of cognitive self-regulation on the relation between emotion knowledge and emotionality

Between three and five years of age, both emotional competence (EC) and cognitive self-regulation (CSR) have been documented as undergoing remarkable growth and as being strong predictors of concur...
Why Richard Cory Offed Himself or One Reason to Take a Course in Probability

(2007). Why Richard Cory Offed Himself or One Reason to Take a Course in Probability. Mathematics Magazine: Vol. 80, No. 4, pp. 273-273.
Medical Student Interest in Flexible Residency Training Options.

Background and objectives Medical residents continue to experience high rates of burnout during residency training even after implementation of the 2003 Accreditation Council for Graduate Medical Education duty-hour restrictions. The purpose of this study is to determine medical student interest in flexible residency training options. Methods Researchers developed an 11-question survey for second through fourth-year medical students. The populations surveyed included medical students who were: (1) attending the 2015 American Academy of Family Physicians National Conference, the 2015 Family Medicine Midwest Conference, and (2) enrolled at University of Chicago Pritzker School of Medicine, University of Illinois College of Medicine at Chicago, Drexel University College of Medicine, and Case Western Reserve University School of Medicine. Results The survey was completed by 789 medical students. Over half of medical students surveyed indicated that they would be interested in working part-time during some portion of their residency training (51%), and that access to part-time training options would increase their likelihood of applying to a particular residency program (52%). When given the option of three residency training schedules of varying lengths, 41% of male students and 60% of female students chose a 60-hour workweek, even when that meant extending the residency length by 33% and reducing their yearly salary to $39,000. Conclusions There is considerable interest among medical students in access to part-time residency training options and reduced-hour residency programs. This level of interest indicates that offering flexible training options could be an effective recruitment tool for residency programs and could improve students' perception of their work-life balance during residency.
Analyzing the Role of the Project Consultant: Cultural Change Implementation

Manufacturers typically operate in a steady-state mode and may be inadequately prepared to deal with large projects, especially those involving major cultural changes. This paper integrates the Pro...
Emissivity Measurements and Modeling of Silicon-Related Materials: An Overview

An overview of the emissivity measurements and modeling of silicon-related materials is presented. The experimental component of this investigation is based on results obtained utilizing spectral emissometry. An analysis of the comparison of the measured data with other similar approaches is made. In particular, the celebrated work of Sato is revisited to understand the implications of his study. Simulations of the temperature and wavelength dependent emissivity of silicon based on the semiempirical MULTIRAD model are presented. The influence of doping concentration, surface roughness, and coatings on the emissivity of silicon, as a function of temperature, is discussed.
Urban Life: Future Developments

The future of urban settlements, as was their past, will likely be driven by three fundamental mechanisms. First, the changing technology of the digital economy will reshape the possibilities of urban life over the next generation. Second, the limits of post-1945 development patterns, especially the low density suburban form prevalent in the United States for 50 years, will be tested. Third, the attractive power of centers will wax or wane; given the diminished power and autonomy of the large industrial urban center over the preceding century, this third mechanism is likely to be closely related to changes in the first two. The multiple contingencies of these and other mechanisms will frame the important issues facing decision makers over the coming decades. Three are already apparent. First, if largeness is a consequence of a passing industrial era, then how will the more fundamentally urban quality of density be manifest in the coming decades? Second, if the well-known mismatch between formal and informal urban organization (local–state–national versus neighborhood–regional–global) is accurate, then how resistant or malleable will formal structures be in the service of informal imperatives? Third, urban life will confront the access issue of personal automobiles versus every other form of mobility. While epitomized in US settlements, this tension is rapidly becoming global in both its prevalence and its consequences.
Clinical Evaluation of an Individualized Risk Prediction Tool for Men on Active Surveillance for Prostate Cancer.

Abstract Objective To determine whether providing individualized predictions of health outcomes to men on active surveillance (AS) alleviates cancer-related anxiety and improves risk understanding. Materials and Methods We consecutively recruited men from our large, institutional AS program before (n = 36) and after (n = 31) implementation of a risk prediction tool. Men in both groups were surveyed before and after their regular visits to assess their perceived cancer control, biopsy-specific anxiety, and burden from cancer-related information. We compared pre-/post-visit differences between men who were and were not shown the tool using two-sample t-tests. Satisfaction with and understanding of the predictions were elicited from men in the intervention period. Results Men reported a relatively high level of cancer control at baseline. Men who were not shown the tool saw a 6.3 point increase (scaled from 0 to 100) in their perceived cancer control from before to after their visit whereas men who were shown the tool saw a 12.8 point increase, indicating a statistically significant difference between groups (p = .04). Biopsy-specific anxiety and burden from cancer information were not significantly different between groups. Men were satisfied with the tool and demonstrated moderate understanding. Conclusion Providing individualized predictions to men on AS helps them better understand their cancer risk and should be considered at other clinical sites.
A rarity in breast pathology: First recurrent male case of Rosai-Dorfman disease.

Abstract Introduction Rosai-Dorfman Disease (RDD) is a rare pathological finding in the breast. Although it is usually palpated as a breast mass, it can be identified on ultrasound or mammogram. The hallmark of the disease is histiocytes with emperipolesis. The case presented in this study represents the first known documented male breast recurrence of RDD and the first association of the disease with pseudoangiomatous stromal hyperplasia (PASH). Presentation of case A 55-year-old male, with a prior history of right breast excisional biopsy of a mass in 2015 that showed RDD, presented to our breast clinic for follow up. A breast sonogram showed a hypoechoic mass. Biopsy and excision were performed revealing recurrent RDD along with PASH. Discussion RDD is a benign condition that normally presents in lymph nodes but can present in extranodal sites, such as the breast. Location and symptoms guide treatment which can include medical or surgical therapy. PASH of the breast is a benign process that may be amenable to treatment by observation, medical management, or surgical excision. Treatment continues to be controversial given the lack of long term sequelae. Conclusion Definitive treatment for RDD of the breast and PASH has not been established. Based on the available data in the literature, our conclusion is that recurrent RDD of the breast can be observed without need for surgical therapy.
A Multi-Institutional Study of Dental Student Readiness to Address Adolescent Risk Behaviors.

The aim of this replication study was to determine if prior findings at one U.S. dental school about dental students’ comfort discussing and perceptions of the relevance of 15 risk behaviors to adolescent patient oral health care would be observed at other institutions. All first- and fourth-year dental students (n=414) at three U.S. dental schools in fall 2017 were invited to participate, and 218 completed the survey (52.7% response rate). These students reported feeling comfortable to uncomfortable discussing risk behaviors with adolescent patients, yet perceived those risk behaviors as relevant to their oral health. There were significant differences in student comfort discussing risk behaviors with adolescents and their perceptions of relevance by gender, age, class status, and school location. Males were more comfortable than females discussing oral health risk behaviors. There were no significant differences by race/ethnicity. Fourth-year students had higher levels of comfort discussing risk behaviors than first-year students. Compared to students in the South and Midwest schools, students at the West school were more comfortable discussing selected topics and had higher perceptions of their relevance to adolescent oral health care. These results suggest there is room for improvement in this area of dental education. Dental schools should aim to strengthen students’ knowledge of and comfort in discussing oral health risk behaviors with adolescent patients with the use of educational activities and clinical experiences.
On Lagrangian fibrations by Jacobians, II

Let Y → ℙn be a flat family of reduced Gorenstein curves, such that the compactified relative Jacobian $X = \overline{J}^d(Y/{\mathbb P}^n)$ is a Lagrangian fibration. We prove that X is a Beauville–Mukai integrable system if n = 3, 4, or 5, and the curves are irreducible and non-hyperelliptic. We also prove that X is a Beauville–Mukai system if n = 3, d is odd, and the curves are canonically positive 2-connected hyperelliptic curves.
Microglial Self-Recognition STINGs in A-T Neurodegeneration

Microglial inflammation is often seen as a secondary event in neurodegeneration. A recent study by Song et al. demonstrates that loss of ataxia telangiectasia mutated (ATM) activates microglia through the cytosolic DNA sensor STING. This highlights the ability of microglia to recognize and respond to self-DNA, with potentially neurotoxic consequences.
Implementation of Team-Based Learning: a Tale of Two New Medical Schools

Team-based learning (TBL) is gaining popularity at medical schools transitioning from lecture-based to active learning curricula. Here, we review challenges and opportunities faced in implementing TBL at 2 new medical schools. We discuss the importance of using meaningful TBL grades as well as the role TBL plays in developing critical reasoning skills and in early identification of struggling students. We also discuss how the concurrent use of learning strategies with different incentive structures such as problem- and case-based learning could foster the development of well-rounded physicians. We hope this monograph helps and even inspires educators implementing TBL at their schools.
Integration of Science Disciplinary Core Ideas and Environmental Themes through Constructivist Teaching Practices

A descriptive, mixed methods study investigated learning outcomes and processes of integrating environmental education (EE) and science education (SE). Specifically, this study examined the impact of EE-based constructivist science teaching approach on students’ science achievement scores, environmental self-efficacy, course completion rate, and perceptions of their learning experiences. Participants of the study (N=46) included students in a Physical Science course at one public high school in a southeastern state of the United States. Data sources included the students’ final exam scores, standardized unit test scores, self-efficacy measurements, course completion data, and student written reflections. Data analysis indicated that students with an EE-based constructivist science teaching approach (N=23) performed higher on science achievement tests and developed statistically higher environmental self-efficacy than those in a traditional teaching classroom (N=23). More students passed the final exam (96%) and the mean final exam score was four points higher (82) in EE-based constructivist teaching approach classes. Students who were in the EE-based constructivist science teaching approach classroom tended to perceive their learning experiences in more positive ways.
Quantitative study of the spatial angles among cardiac chambers and great vessels in the normal fetuses by spatiotemporal image correlation

Objective To establish the reference ranges of the spatial angles among cardiac chambers and great vessels in second and third trimester fetuses measured by spatiotemporal image correlation (STIC).Methods Volume images of 352 normal fetuses from 20 to 38 weeks of gestation were recruited in the study.An off-line analysis of acquired volume datasets was carried out with multiplanar mode.Parameters measured included angles between:(1) the 4-chamber view and the left ventricular long axis view; (2) the left ventricular long axis view and main pulmonary artery; and (3) the ductal arch and aortic arch.The relationships between above-mentioned angles and gestational age were assessed by correlation and regression analysis.Results The angle between the 4-chamber view and the left ventricular long axis view (range:55.7° - 35.7°,mean:45.7° ± 5.12°) was uncorrelated with gestational age (r = 0.03,P = 0.51).In contrast,the angle between the left ventricular long axis view and main pulmonary artery,and the angle between the ductal arch and aortic arch were correlated with gestational age (P ＜ 0.001),and the correlation coefficient was - 0.53 and 0.57 respectively.The best-fit exponential curve regression equations of the angle between the left ventricular long axis view and main pulmonary artery was:Y = 154- 4.24X +0.05X2 ,and the angle between the ductal arch and aortic arch was:Y = - 20.8 + 2.65X - 0.37X2.Conclusions The angles among cardiac chambers and great arteries of fetuses from 20 to 38 weeks of gestation can be quantitatively measured by STIC.The reference ranges provide a reliable quantitative standard to estimate the spatial relationships of the cardiac large arteries of fetuses,which may be clinically useful in prenatal screening congenital heart disease. Key words: Ultrasonography,prenatal; Fetal heart ; Spatiotemporal image correlation
A Case Study of the Use of Newsela PRO Among Adult, Emergent Bi/Multilingual Learners in a Precollege Program

Adult literacy and English as an Additional Language (EAL) programs are often challenged to find suitable and authentic reading texts and instructional materials for their students. Newsela PRO, an...
Complications and Failure to Rescue After Inpatient Pediatric Surgery.

OBJECTIVE To describe the frequency and patterns of postoperative complications and failure to rescue (FTR) after inpatient pediatric surgical procedures and to evaluate the association between number of complications and failure to rescue. SUMMARY AND BACKGROUND FTR, or a postoperative death after a complication, is currently a nationally endorsed quality measure for adults. While it is a contributing factor to variation in mortality, relatively little is known about FTR after pediatric surgery. METHODS Cohort study of 200,554 patients within the National Surgical Quality Improvement Program-Pediatric database (2012-2016) who underwent a high (≥1%) or low (<1%) mortality risk inpatient surgical procedures. Patients were stratified based on number of postoperative complications (0, 1, 2, or ≥3) and further categorized as having undergone either a low- or high-risk procedure. The association between the number of postoperative complications and FTR was evaluated with multivariable logistic regression. RESULTS Among patients who underwent a low- (89.4%) or high-risk (10.6%) procedures, 14.0% and 12.5% had at least one postoperative complication, respectively. FTR rates after low- and high-risk procedures demonstrated step-wise increases as the number of complications accrued (e.g.: low-risk-9.2% in patients with ≥3 complications; high-risk-36.9% in patients with ≥3 complications). Relative to patients who had no complications, there was a dose-response relationship between mortality and the number of complications after low-risk (1 complication - Odds Ratio [OR] 3.34 [95% CI 2.62-4.27]; 2 - OR 10.15 [95% CI 7.40-13.92]; ≥3-27.48 [95% CI 19.06-39.62]) and high-risk operations (1 - OR 3.29 [2.61-4.16]; 2-7.24 [5.14-10.19]; ≥3-20.73 [12.62-34.04]). CONCLUSIONS There is a dose-response relationship between the number of postoperative complications after inpatient surgery and FTR, ever after common, 'minor' surgical procedures. These findings suggest FTR may be a potential quality measure for pediatric surgical care.
EDUCAÇÃO, ESTRUTURAÇÃO IDEOLÓGICA, SUPORTE POR POLÍTICAS SOCIAIS E ESCOLHA ELEITORAL

RESUMO O objetivo deste artigo e investigar como a educacao afeta 1) a estruturacao das atitudes por politicas sociais, definida como a correlacao entre atitudes em diversas areas – por exemplo, educacao, saude, redistribuicao de renda e seguridade social –, e 2) a relacao dessa estruturacao com o voto em partidos de diferentes filiacoes ideologicas. Mostra-se que o acumulo de escolarizacao aumenta a estruturacao das atitudes, bem como que, em caso de atitudes mais estruturadas que ganhem conteudo ideologico a favor/contra politicas sociais, e somente quando a escolarizacao e alta que esses posicionamentos se associam mais fortemente com o voto em partidos de esquerda/direita. Analisam-se opinioes politicas e comportamento eleitoral coletados em surveys de opiniao, no ano de 2016, em mais de trinta paises.
Voices from the front line: Supporting staff during the COVID-19 pandemic.

“I’m new here and don’t have any family nearby. Plus, I live alone. This is harder than I would’ve imagined. It’s really lonely.”“The work I do has always been pretty solitary. But I miss having al...
APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number.

Aberrant centrosome numbers are associated with human cancers. The levels of centrosome regulators positively correlate with centrosome number. Thus, tight control of centrosome protein levels is critical. In Caenorhabditis elegans, the anaphase-promoting complex/cyclosome and co-activator FZR-1 (APC/CFZR-1) ubiquitin ligase negatively regulates centrosome assembly through SAS-5 degradation. In this study, we report the C. elegans ZYG-1 (Plk4 in human) as a potential substrate of APC/CFZR-1. Inhibiting APC/CFZR-1 or mutating a ZYG-1 destruction (D)-box leads to elevated ZYG-1 levels at centrosomes, restoring bipolar spindles and embryonic viability to zyg-1 mutants, suggesting that APC/CFZR-1 influences centrosomal ZYG-1 via D-box motif. We also show the Slimb/βTrCP-binding (SB) motif is critical for ZYG-1 degradation, substantiating a conserved mechanism by which ZYG-1/Plk4 stability is regulated by SCFSlimb/βTrCP-dependent proteolysis via the conserved SB motif in C. elegans. Furthermore, we show that co-mutating ZYG-1 SB and D-box motifs stabilizes ZYG-1 in an additive manner, suggesting that APC/CFZR-1 and SCFSlimb/βTrCP ubiquitin ligases function cooperatively for timely ZYG-1 destruction in C. elegans embryos where ZYG-1 activity remains at threshold level to ensure normal centrosome number.
Impact of Covid-19 Pandemic on Racial/Ethnic Differences in Mortality by Cause of Death

This paper documents changes in mortality by race and ethnicity between 2019 and 2020. Using age-standardized death rates, it attributes changes for Black, Hispanic, and White populations to various underlying causes of death and shows how these racial and ethnic patterns vary by age and sex. Hispanic individuals had the largest increase in mortality attributed to Covid-19, but Black individuals had the largest increase in all-cause mortality. Exceptionally large increases in mortality from heart disease, diabetes, and external causes of death account for the adverse trend in all-cause mortality within the Black population. For the Black and White populations, percentage increases in all-cause mortality were similar for men and women and for ages 25-64 and 65+. Among the Hispanic population, however, percentage increases in mortality were greatest for working-aged men. Results are very similar when 2020 death rates are compared to those in 2019 and when they are compared to projected 2020 rates based on a time series extrapolation of death rates from 2015 to 2019.
History of Bilirubin

The history of bilirubin actually goes back many hundreds of years, when newborn infants were observed to be jaundiced.More recent accounts of jaundice in newborns seems to have begun in the late eighteenth century.One of those was written by Jean Baptiste Thimotee Baumes (Baumes, J. 1806).This description was published as a chapter in a book entitled Traite de L’amaigrissemwnt des enfans.The chapter relating to jaundice is entitled Traite de L’ictere ou jaunisse des enfans de naissance.
Temporal evaluation of left ventricular remodeling and function in rats with chronic volume overload

The left ventricle (LV) significantly dilates and hypertrophies in response to chronic volume overload. However, the temporal responses in LV mass, volume, and systolic/diastolic function secondary...
Peritonitis following the vaginal douche and a proposed alternative method for vaginal and vulvar care

Abstract Nine cases of pelvic peritonitis following vaginal douching are reported. A self-bathing technique for washing the vulva and vagina was described. Five hundred and forty women were studied. Three hundred and sixty asymptomatic women performed the bathing routine daily. Ninety-four women with symptomatic Trichomonas vaginalis vaginitis were all relieved of symptoms within 7 days and examination did not disclose the flagellates after 7 days of treatment in 94.7 per cent of women. Fifty-eight of 62 (93.6 per cent) women with nonspecific vulvovaginitis obstained relief by use of the advocated bathing procedure in 7 days. The recurrence rate was 35.3 per cent and 41.7 per cent, respectively, in women who did not follow the suggested daily bathing and slightly over 5 per cent in those women who followed the bathing technique.
Solid-State, Dye, and Semiconductor Lasers

In this chapter, the most important types of lasers involving high density active media are considered, namely solid-state, dye and semiconductor lasers. The chapter concentrates on those examples that are in widest use and whose characteristics are representative of a whole class of lasers. The main emphasis here is on stressing the physical behavior of the laser and relating this behavior to the general concepts developed in the previous chapters. Some engineering details are also provided with the main aim again of helping to provide for a better physical insight into the behavior of the particular laser. To complete the picture, some data relating to laser performances (e.g., oscillating wavelength(s), output power or energy, wavelength tunability, etc.) are also included to help providing some indication of the laser’s applicability. For each laser, after some introductory comments, the following items are generally covered: (1) Relevant energy levels; (2) excitation mechanisms; (3) characteristics of the laser transition(s); (4) engineering details of the laser structure(s); (5) characteristics of the output beam; (6) applications.
Choosing Law: The Limitations Debates

In this article, Professor Weinberg discusses the recent Supreme Court case of Sun Oil Co. v. Wortman and the problems facing courts confronted with conflicting statutes of limitations. She uses the modern choice-of-law technique of interest analysis. In exploring Wortman, she identifies an unnoticed problem of interest analysis, the problem of "the fractional interest," and examines recent class suits and Commerce Clause cases raising that problem. She concludes that the Wortman Court correctly rejected the "substantive" model of choice of limitations law and correctly decided that the forum should be allowed to apply its own longer statute of limitations even if its only connections with a case are jurisdictional. But she believes that courts should not use the "procedural" model simply because it yields this result. Rather, courts should employ the same analytic reasoning in choosing limitations law as in other conflicts problems.
The Logic of Normative Systems

This paper exploits the properties of adjointness to develop a theory of norms. The adjoints are a pair of mappings between two logics, one called IMP, a logic of imperatives, and another called PROP, which is ordinary logic. In particular, L is a mapping form Prop to IMP and it has a right adjoint R from IMP to PROP. Norms are defined, formally, as statements that contain occurrences of RU where U is in IMP. A sample theorem (reminiscent of Kant’s “ought implies can”): Responsibility implies power and, moreover, incapacity implies immunity.
Room-temperature electronic phase transitions in the continuous phase diagrams of perovskite manganites

Highly correlated electronic systems—such as transition-metal oxides that are doped Mott insulators—are complex systems which exhibit puzzling phenomena, including high-temperature superconductivity and colossal magnetoresistivity. Recent studies1,2,3 suggest that in such systems collective electronic phenomena are important, arising from long-range Coulomb interactions and magnetic effects. The qualitative behaviour of these systems is strongly dependent on charge filling (the level of doping) and the lattice constant. Here we report a time-efficient and systematic experimental approach for studying the phase diagrams of condensed-matter systems. It involves the continuous mapping of the physical properties of epitaxial thin films of perovskite manganites (a class of doped Mott insulator) as their composition is varied. We discover evidence that suggests the presence of phase boundaries of electronic origin at room temperature.
Recent Results of (n,p) Studies at Intermediate Energies

In recent years charge-exchange reactions from nuclei at intermediate energies have been the subject of intensive studies. At these energies, isovector spin excitations are preferentially induced in nuclei making these reactions extremely sensitive to these aspects of nuclear structure. At the last Telluride conference, Jackson and Celler (1) reported on the (n,p) reaction as a probe of nuclear structure. New results will be presented here, mainly those obtained with the recently implemented white neutron source at LAMPF-WNR.
An expert system for academic advising

Summary form only given, as follows. To augment the advice of professors for student course selection, an expert system called ADVISING has been designed and implemented. The author discusses a prototype system for the Engineering Management PhD Program at Old Dominion University. Course selections are derived from the student's concentration area, progress in the program, course prerequisites, and specific interests. >
Clinical Performance of a Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Method for Detection of Certain blaKPC-Containing Plasmids

Rapid detection of blaKPC-containing organisms can significantly impact infection control and clinical practices, as well as therapeutic choices. Current molecular and phenotypic methods to detect these organisms, however, require additional testing beyond routine organism identification. In this study, we evaluated the clinical performance of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) to detect pKpQIL_p019 (p019)-an ∼11,109-Da protein associated with certain blaKPC-containing plasmids that was previously shown to successfully track a clonal outbreak of blaKPC-pKpQIL-Klebsiella pneumoniae in a proof-of-principle study (A. F. Lau, H. Wang, R. A. Weingarten, S. K. Drake, A. F. Suffredini, M. K. Garfield, Y. Chen, M. Gucek, J. H. Youn, F. Stock, H. Tso, J. DeLeo, J. J. Cimino, K. M. Frank, and J. P. Dekker, J Clin Microbiol 52:2804-2812, 2014, http://dx.doi.org/10.1128/JCM.00694-14). PCR for the p019 gene was used as the reference method. Here, blind analysis of 140 characterized Enterobacteriaceae isolates using two protein extraction methods (plate extraction and tube extraction) and two peak detection methods (manual and automated) showed sensitivities and specificities ranging from 96% to 100% and from 95% to 100%, respectively (2,520 spectra analyzed). Feasible laboratory implementation methods (plate extraction and automated analysis) demonstrated 96% sensitivity and 99% specificity. All p019-positive isolates (n = 26) contained blaKPC and were carbapenem resistant. Retrospective analysis of an additional 720 clinical Enterobacteriaceae spectra found an ∼11,109-Da signal in nine spectra (1.3%), including seven from p019-containing, carbapenem-resistant isolates (positive predictive value [PPV], 78%). Instrument tuning had a significant effect on assay sensitivity, highlighting important factors that must be considered as MALDI-TOF MS moves into applications beyond microbial identification. Using a large blind clinical data set, we have shown that spectra acquired for routine organism identification can also be analyzed automatically in real time at high throughput, at no additional expense to the laboratory, to enable rapid detection of potentially blaKPC-containing carbapenem-resistant isolates, providing early and clinically actionable results.
High-temperature applications of solid-state ionics

Abstract Useful high-temperature materials have rare combinations of chemical stability, electrical properties and mechanical strength. The most successful materials are oxides which are chemically stable in most high-temperature environments. Attractive applications of novel oxide materials include ionic conductors in chemical sensors, electronic conductors in high-temperature fuel cells, and mixed-conducting oxide electrodes. Fundamental research opportunities in solid-state ionics include conductivity mechanisms in oxide mixed conductors, gas-oxide reactions at elevated temperatures and the structure and properties of oxide grain boundaries.