cssi/SciSciGPT-SciSciNet huggingface dataset:
Thermal history and temperature-dependent photon echo and hole burning linewidths in low temperature glycerol glasses

Abstract Temperature-dependent two-pulse photon echo and hole burning linewidths are reported for the system resorufin in glycerol glass from 1 to 25 K. At low temperature a factor of ≈4 difference between the linewidths measured by the two techniques is observed owing to the broad fluctuation rate distribution of glass dynamics. Using cooling rates of 600 K/min and 0.2 K/min. it is shown that the linewidth of both spectroscopies is markedly dependent on how the sample was prepared. In terms of the two level system model of glass dynamics, the cooling rate dependence has direct implications on the structure of the glass at low temperature.
Cancer Chemotherapy and Contraceptive Counseling

Contraceptive counseling for patients receiving antineoplastic agents is illustrated by the case of a patient with Hodgkin's disease. After the patient began treatment, he married his girlfriend and desired to have children in the near future. Clinicians are alerted to the sexual needs of the cancer patient and the need for contraception assessment in patients of reproductive years. An outline for informing cancer patients about contraception is provided.
Animal Behavior: The Orphan Rebellion

After their queen has left with a swarm, orphaned larvae exhibiting rebel traits emerge in honeybee colonies. As adults, these orphans have reduced food glands to feed the colony's larvae and more developed ovaries to selfishly reproduce their own offspring.
Searching for resilience among African-American youth exposed to community violence : Theoretical issues

PURPOSE: The exploration of resilience factors which may moderate the impact of violence exposure on African-American youth living in high-crime neighborhoods has received scant research attention. Yet, how these adolescents appraise and cope with exposures to violent events has implications for social adaptation and resilience. This article attempts to organize diverse literatures and cross-disciplinary perspectives into an integrative framework for the study of resilience among African-American youth exposed to violence. METHODS: The search for protective factors requires critical examination of both the ethnocentric bias in traditional developmental frameworks and the decontextualization of sociocultural and environmental influences on adaptation. A paradigmatic refocusing is necessary, one which highlights the capacities for coping and adaptation resulting from the engagement of personal resources, family strengths, and community support systems. RESULTS: To facilitate this research, an appraisal and coping model of violence is presented. This model emphasizes the need to identify and assess the appraisal processes and coping strategies initiated by African-American families as they attempt to thrive amidst community violence. CONCLUSIONS: Protective factors, operative at different junctures and within different ecologies, may reduce the likelihood of maladaptation or promote social competence in African-American youth exposed to violence. This search for resilience must address the meaning of competence and mechanisms of familial and external support that are salient within the African-American community. Language: en
A Retrospective Naturalistic Study of Ziprasidone for Irritability in Youth with Autism Spectrum Disorder.

Abstract Objective: The purpose of this study was to assess the impact of ziprasidone monoantipsychotic treatment targeting irritability in a naturalistic outpatient autism spectrum disorder (ASD) clinical setting. Methods: We examined the use of ziprasidone, predominantly in combination with other psychotropic agents, targeting irritability in 42 youth with ASD in a large ASD-specific treatment database. Mean age at start of treatment, treatment duration, final dose, body mass index (BMI), BMI Z score, and Clinical Global Impressions-Improvement Scale (CGI-I) score at final visit were determined, and changes with treatment were analyzed using paired t tests. Cardiac corrected QT (QTc) interval data were extracted from electrocardiograms when available. Results: Mean age at start of treatment was 11.8 years. And final mean dose of ziprasidone was 98.7 mg/day or 1.7 mg/kg/day. Seventeen (40%) participants were considered treatment responders based on the CGI-I. No changes in QTc (although only examined in ...
Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease.

Background: Serotonin has been linked to neuropsychiatric symptoms in Alzheimer disease, mainly agitation/aggression, depression, and psychosis. Neuropsychiatric symptoms have been associated with polymorphisms of the promoter region (5-HTTPR) and intron 2 of the serotonin transporter gene (5-HTTVNTR )o r the5-HT2A and 5-HT2C receptor genes in some but not all studies. Objective: To examine the association of the serotonin promoter, transporter, and receptor genes with neuropyschiatric symptoms in patients with Alzheimer disease. Methods: The sample included 96 patients with Alzheimer disease from the outpatient clinic of the University of California Los Angeles Alzheimer’s Disease Research Center, Los Angeles. The Neuropsychiatric Inventory was used to measure neuropsychiatric symptoms,andbloodsampleswereavailableforgeneticanalysis. Based on the literature, we hypothesized that the 5-HT2A and 5-HT2C receptor polymorphisms would be associated with agitation/aggression and psychosis and the 5-HTTPR or 5-HTTVNTR polymorphisms, with agitation/aggression or depression and anxiety. One-way analyses of variance were performed with age, ethnicity, sex, or education as covariates. Results: The 102T genotype of the 5-HT2A receptor was significantly associated with delusions (P=.045) and agitation/aggression (P=.002). We did not replicate previous associations of the 5-HT2C receptor polymorphism with psychosis or of the 5-HTTPR polymorphism with agitation/aggression, psychosis, or depression. We did not find any associations with the 5-HTTVNTR polymorphism and agitation/aggression, depression, or anxiety. Conclusions:The5-HT2Areceptor polymorphism may contribute to the expression of psychosis and agitation/ aggression in patients with Alzheimer disease. Absence of other positive associations may be due to the relativelysmallsamplesizeand/orpotentiallysmalleffectsize of the polymorphisms and requires further study. Arch Neurol. 2004;61:1249-1253
Optimal booking and scheduling in outpatient procedure centers

Patient appointment booking, sequencing, and scheduling decisions are challenging for outpatient procedure centers due to uncertainty in procedure times and patient attendance. We extend a previously developed appointment scheduling model to formulate a model based on a two-stage stochastic mixed integer program for optimizing booking and appointment times in the presence of uncertainty. The objective is to maximize expected profit. Analytical insights are reported for special cases and experimental results show that they provide useful rules of thumb for more general problems. Three solution methods are described which take advantage of the underlying structure of the stochastic program, and a series of experiments are performed to determine the best method. A case study based on an endoscopy suite at a large medical center is used to draw a number of useful managerial insights for procedure center managers.
Multi-Institutional Reciprocal Validation Study of Computed Tomography Predictors of Suboptimal Primary Cytoreduction in Patients With Advanced Ovarian Cancer

Purpose Identify features on preoperative computed tomography (CT) scans to predict suboptimal primary cytoreduction in patients treated for advanced ovarian cancer in institution A. Reciprocally cross validate the predictors identified with those from two previously published cohorts from institutions B and C. Patients and Methods Preoperative CT scans from patients with stage III/IV epithelial ovarian cancer who underwent primary cytoreduction in institution A between 1999 and 2005 were retrospectively reviewed by radiologists blinded to surgical outcome. Fourteen criteria were assessed. Crossvalidation was performed by applying predictive model A to the patients from cohorts B and C, and reciprocally applying predictive models B and C to cohort A. Results Sixty-five patients from institution A were included. The rate of optimal cytoreduction (≤ 1 cm residual disease) was 78%. Diaphragm disease and large bowel mesentery implants were the only CT predictors of suboptimal cytoreduction on univariate (P < ...
Can Intraoperative Processed EEG Predict Postoperative Cognitive Dysfunction in the Elderly

Abstract Purpose Postoperative cognitive dysfunction (POCD) is a serious and costly complication of the elderly; even mild impairment has the potential to impact overall well being. Anesthesiologists continue to search for ways to manipulate intraoperative technique to optimize postoperative cognition in the elderly. Depth of anesthesia during surgery is an area that has shown some promise for short-term outcomes, such as delirium. However, excessive depth has both positive and negative associations with longer-term POCD. We hypothesize that this uncertainty is due to the inability of median depth to capture the amount of burst suppression or electrical silence. In this study, our purpose was to identify the intraoperative processed EEG parameters that are most closely correlated with POCD. Methods To explore the association of several processed EEG parameters with POCD, we performed a retrospective analysis of a cohort of 105 patients aged >68 years scheduled for major surgery under general anesthesia. Intraoperative medications, hemodynamics, processed EEG and cerebral oxygen saturation were recorded. All patients had a cognitive battery before surgery and repeated at 3 months afterward. Findings One hundred and five patients enrolled and 77 (73.3%) patients completed the 3-month cognitive testing. The incidence of POCD was 27%; the median Bispectral Index value for patients who developed POCD was similar to patients who did not (46 vs 42 minutes). However, patients who developed POCD spent less time with Bispectral Index P = 0.01) and burst suppression (35 vs 96 minutes, P = 0.04). Hypotension, cerebral desaturation, and use of total intravenous anesthesia were similar between patients with and without POCD. Implications Patients who developed POCD spent less time in EEG burst suppression and less time in deep states. Burst suppression may be protective for POCD. Further work is needed to definitively identify the role of burst suppression in the context of other patient and intraoperative variables to prevent POCD.
VALUE OF CONTENT: AN INVISIBLE PROBLEM FOR BEGINNING SOCIAL STUDIES TEACHERS

One enduring theme in history and the social studies educational reform literature is that many students do not like or find useful their history and social studies courses. History and social studies teachers try numerous ways to garner students’ interest in the content, such as reenactments, activities, and storytelling. Often, however, students do not seem to grasp the intrinsic value of the content. This paper describes a study of seven history and social studies student teachers and how they thought about and taught the value of history and social studies content in their lessons. My findings indicate that these student teachers either had not considered the value of the content in their planning or had trouble making the value explicit in their teaching. This paper concludes by presenting a framework that emerged from the study that gives teachers a starting place to think more carefully about the value of history and social studies content for students.
Reputations in Bidding Fee Auctions

This paper analyzes bidding fee auctions --- an auction format in which bidders pay a fee every time they bid. In these auctions, the prize value diminishes as the auction progresses, and the person who pays the most does not necessarily win. Bidding fee auction websites are an increasingly common way to shop online. In my sample of 52 million bids from 64,000 auctions, there is heavy overbidding as revenues routinely double prize values. Even experienced users frequently earn negative returns. Despite this apparent violation of individual-rationality constraints, bidders generally respond to underlying economic incentives. I identify the aggressive strategies employed by savvy users and I interpret the causes of their (relative) success.
Three-dimensional linear stability analysis of cavity flows

Numerical Simulations of the two- and three-dimensional linearized Navier–Stokes equations are performed to investigate instabilities of open cavity flows that are homogeneous in the spanwise direction. First, the onset of two-dimensional cavity instability is characterized over a range of Mach numbers, Reynolds numbers and cavity aspect ratios. The resulting oscillations are consistent with the typical Rossiter flow/acoustic resonant modes. We then identify the presence of three-dimensional instabilities of the two-dimensional basic flow and study their dependence on the parameter space. In general, the most amplified three-dimensional mode has a spanwise wavelength scaling with the cavity depth, and a frequency typically an order-of-magnitude smaller than two-dimensional Rossiter modes. The instability appears to arise from a generic centrifugal instability mechanism associated with a large vortex in the two-dimensional basic flow that occupies the downstream portion within the cavity.
Modulation of Core Turbulent Density Fluctuations by Large-Scale Neoclassical Tearing Mode Islands in the DIII-D Tokamak.

We report the first observation of localized modulation of turbulent density fluctuations $\stackrel{\texttildelow{}}{n}$ (via beam emission spectroscopy) by neoclassical tearing modes (NTMs) in the core of the DIII-D tokamak. NTMs are important as they often lead to severe degradation of plasma confinement and disruptions in high-confinement fusion experiments. Magnetic islands associated with NTMs significantly modify the profiles and turbulence drives. In this experiment $\stackrel{\texttildelow{}}{n}$ was found to be modulated by 14% across the island. Gyrokinetic simulations suggest that $\stackrel{\texttildelow{}}{n}$ could be dominantly driven by the ion temperature gradient instability.
Aspects of Visual Attraction: Attention-Getting Model for Art and Design

AbstractThis paper describes a model that can he used in the context of visual literacy to investigate the role that the brain has on visual messages. Attention-getting is defined as being composed of three main elements, namely unusual, emotionally salient and involuntary neuro-hiological stimulus. The model is used as a departing point to analyze four different visual message strategies, ranging from two-dimensional to three-dimensional forms.
Mandarin learners' (L2) comprehension of zero anaphora in Mandarin phone conversations

This article analyzes patterns of comprehension of zero anaphor by native-English-speaker learners of Mandarin in recordings and transcriptions of four naturally occurring Mandarin telephone conversations. Because many ana- phoric pronouns have no overt expression in Mandarin, comprehension of even basic clause constituents of Mandarin texts can require discourse-level inferencing that English does not require. Despite these differences between English and Mandarin, intermediate to advanced level Mandarin learners in this study were able to successfully interpret and translate zero anaphor in these telephone conversation texts about 72% of the time. The greatest difficulties with zero anaphor were related to a) instances in which the initial, explicitly expressed antecedent was misinterpreted, and b) shifts in footing, or verbal activity, in which speakers moved, for example, from narrative description to direct address of interlocutor or personal evaluation of a situation just described. These patterns suggest that greater awareness of discourse level structures in naturally occurring verbal interaction - which could be taught through explicit instruction - might help intermediate and advanced Mandarin learners to correctly interpret a broader range of zero anaphora.
Aggressive temperament predicts ethanol self-administration in late adolescent male and female rhesus macaques.

Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relation to future or prior ethanol intake. The objective of the study was to test the association between temperament at baseline with future ethanol self-administration in late adolescent male (n = 21) and female (n = 11) rhesus monkeys. Shortly after entering the laboratory and before exposure to ethanol, the Human Intruder Test (HIT) and the Novel Object Test (NOT) were used to determine baseline anxious-like and aggressive-like behavior in age-matched male and female rhesus monkeys (Macaca mulatta). The monkeys were induced to drink ethanol 4 % (w/v) using a schedule-induced polydipsia procedure, followed by “open-access” ethanol self-administration in which the monkeys were allowed a choice of water or 4 % ethanol (w/v) for 22 h/day for 52 weeks. Aggressive monkeys self-administered more ethanol and attained higher blood ethanol concentrations (BECs). No significant differences in ethanol intakes or BECs were found between anxious and non-anxious monkeys or between behaviorally inhibited and non-inhibited monkeys. Baseline aggressive behavior positively correlated with ethanol intake and intoxication. Baseline reactive aggression was associated with higher future ethanol intake and intoxication. While significant sex differences in HIT reactivity were observed, the relationship between aggression and ethanol drinking was observed across sex and is not sex-specific.
Patients with Long-Term Control of Systemic Disease Are a Favorable Prognostic Group for Treatment of Brain Metastases with Stereotactic Radiosurgery Alone

Background Stereotactic radiosurgery (SRS) alone is an attractive option for treatment of brain metastases. SRS avoids whole-brain radiotherapy (WBRT)-associated morbidity, but is limited by regional central nervous system (CNS) failures and short survival in some patients. We evaluated a subgroup of patients with controlled systemic disease that could represent a favorable patient population for SRS alone. Methods All patients with brain metastases treated with SRS without WBRT at our institution between 2004 and 2014 were grouped into two cohorts: those with controlled systemic disease (CSD) for 1 year or longer before prior to presentation with brain metastases and those without (i.e., uncontrolled systemic disease [USD]). Rates of local and regional CNS failure, and overall survival were assessed with χ 2 and Student t tests. Cox regression analysis was performed to evaluate independent predictors of regional control and overall survival. Results Two hundred ninety-four patients underwent SRS to 697 lesions, of which 65 patients had CSD. Median follow-up was 9.7 months. There was no difference in local control between the two cohorts ( P = 0.795). Regional CNS control was significantly better for patients with CSD (68% vs. 48%; P = 0.001). Overall survival at 1 and 5 years for CSD were 65% and 13% with USD yielding 41% and 7%, respectively ( P P = 0.008) and shorter overall survival (HR, 1.55; P = 0.007). Conclusions Patients with brain metastases after 1 year or longer of primary and systemic disease control represent a particularly favorable cohort, with lower regional CNS failure and prolonged survival, for an approach of SRS alone.
Identification of Sequence-Specific Tertiary Packing Motifs in Protein Structures using Delaunay Tessellation

An approach to recognizing recurrent sequence-structure patterns in proteins has been developed, based on Delaunay tessellation of protein structure. Starting with a united residue (side chain centroids) representation of a protein structure, tessellation partitions the structure into a unique set of irregular tetra-hedra, or simplices whose vertices correspond to four nearest-neighbor residues. Tetrahedral clusters composed of residues not adjacent along the polypeptide chain have been classified according to their amino acid composition and the three distances separating the residues along the sequence; these distances being defined as the sequence lengths from first to second, second to third, and third to fourth residue. An elementary tertiary packing motif is defined as a Delaunay simplex with a specific amino acid composition, together with three sequence distances (i.e., number of residues along the sequence) between vertex residues. Analysis of three databases of diverse protein structures (< 30% sequence identity between any pair, 1922 structures total) identified 224 motifs found in at least two proteins from different fold families each. To further substantiate the methodology, three groups of proteins representing unique structural and functional families were analyzed and packing motifs characteristic of each of them have been identified. The proposed methodology is termed Simplicial Neighborhood Analysis of Protein Packing (SNAPP). SNAPP can be used to locate recurrent tertiary structural motifs as well as sequence-specific, functionally relevant patterns similar to Prosite (Hofmann, et al. 1999) signatures. We anticipate that the SNAPP methodology will be useful in automating the analysis and comparison of protein structures determined in structural and functional genomics projects.
People with disabilities and community participation.

When Alex deTocqueville visited America in 1830 he marveled at how involved America’s citizens were in civic community activities (de Tocqueville, 1883). Such participation in the community was unp...
Medical cannabis use among patients with chronic pain in an interdisciplinary pain rehabilitation program: Characterization and treatment outcomes

Abstract Introduction Cannabis is increasingly being used in the treatment of chronic pain. However, there is a lack of available research in the population of patients with chronic pain who are using cannabis. The current study examines clinical and treatment characteristics for patients who are admitted to a 3-week outpatient interdisciplinary chronic pain rehabilitation program. Method Participants ( N =48) included patients with a positive urine drug screen for 9-carboxy-tetrahydrocannabinol (THC(+); n =24) and a matched comparison sample of patients with a negative screen (THC(−); n =24). Participants were matched for age, gender, race, education, and current prescription opioid use. Measures of pain, functioning, and quality of life were completed at admission and discharge. Medical chart review was conducted to assess medication and substance use history. Results Participants with a positive screen for THC were more likely to report a past history of illicit substance use, alcohol abuse, and current tobacco use. Cannabis use was not associated with a significantly lower morphine equivalence level for participants using prescription opioids ( n =14). Both groups of participants reported significant improvement in pain severity, pain interference, depressive symptoms, and pain catastrophizing. There were no group- or treatment-related differences in these outcome variables. Discussion Results provide preliminary evidence that patients with chronic pain using cannabis may benefit from an interdisciplinary chronic pain program. Patients with chronic pain using cannabis may be at higher risk for substance-related negative outcomes, although more research is needed to understand this relationship.
Salvage guideline for local-regional failure after stereotactic ablative radiotherapy for early-stage non-small cell lung cancer.

8501Background: Up to 1 in 7 patients receiving stereotactic ablative radiotherapy (SABR) for early-stage non-small cell lung cancer (NSCLC) will develop local-regional recurrence. While SABR is th...
A digital optical computing architecture based on regular free-space interconnects

A digital optical computing architecture is described that consists of arrays of identical optical logic gates interconnected in free space with regular interconnection patterns. Advantages of this model include massive parallelism, simplicity in device fabrication, tolerance to processing defects, wide bandwidth access to memory, and gate-level reconfigurability. The success of this model relies heavily on advances in device technology, optical systems design, and the ability to map arbitrary digital problems onto the regular structure. Digital design methods are described that address the mapping problem and support a means of recovery from processing defects while supporting new computing paradigms made possible by the underlying technology. The conclusion is made that this approach simplifies requirements of the optical hardware while providing significant computational advantages.
Comparison of transferrin receptor-mediated endocytosis and drug- induced endocytosis in human neonatal and adult RBCs

Neonatal RBCs can undergo receptor-mediated endocytosis; normal adult RBCs cannot. Previously, we showed that drug-induced endocytosis, which can occur in adult RBCs exposed to amphipathic cations like primaquine, is greatly enhanced in all density-defined fractions of neonatal RBCs. To investigate the similarities and differences between receptor-mediated endocytosis and drug-induced endocytosis, we characterized transferrin receptor-mediated endocytosis in neonatal RBCs and compared it with drug-induced endocytosis. Primaquine drug-induced endocytosis is dependent on RBC ATP levels, is invariably preceded by stomatocytosis, and is inhibited by vanadate. In contrast, receptor-mediated endocytosis of transferrin is not preceded by stomatocytosis, is not nearly so dependent on ATP levels as is drug-induced endocytosis, and is not inhibited by vanadate. Furthermore, receptor-mediated endocytosis is quantitatively blocked by preincubation of neonatal RBCs with sodium cyanide, whereas cyanide does not inhibit drug-induced endocytosis in either adult or neonatal RBCs. Morphologic observation of the neonatal RBCs established the fact that only puckered RBCs that exhibited brilliant cresyl blue staining reticulum were capable of undergoing receptor-mediated endocytosis of transferrin. These characteristics identify them as motile R-1 reticulocytes. Reticulocytes in normal adult RBCs were incapable of exhibiting this phenomenon. Thus, receptor-mediated endocytosis, a property of motile reticulocytes in neonatal RBCs, differs from drug-induced endocytosis in its energy requirements, response to inhibitors, and morphologic concomitants.
A New Model of Modular Automation Programming in Changeable Manufacturing Systems

Abstract Manufacturing systems in Industry 4.0 are changeable, smart, connected and more autonomous. The structure of a changeable manufacturing system allows for physical reconfiguration, however, reprogramming controllers has been always performed manually for each new system configuration. The presented model combines different ladder logic codes corresponding to different system configurations, modularizes them and produces smaller pieces of code, which automatically get merged and downloaded to the different system controllers. The model uses Cladistics and Design Structure Matrix (DSM) to prepare the modular codes. A case study of a changeable robotic assembly system is presented.
Precursor and Preinvasive Lesions

Our understanding of the origins of lung carcinoma is furthered by a careful analysis of the molecular alterations associated with precursor and preinvasive lesions. It is evident from such studies that stepwise progression from the earliest dysplastic and atypical lesions is associated with acquisition of increasingly complex molecular events. Neuroendocrine cell hyperplasia, in its diffuse form, is a recognized precursor of carcinoid tumors. Atypical adenomatous hyperplasia is a precursor of adenocarcinoma and squamous dysplasia a precursor of squamous cell carcinoma. A combination of mutational events, aneuploidy, and epigenetic alterations effects a change in cellular gene expression that cause progression from localized cellular proliferations to invasive tumors with metastatic potential.
Harnessing the power of hashtags in tweet analytics

Twitter is one of the most popular microblogging platforms where users can interact with each other by posting texts of up to 140 characters called tweets. Because of the large and fast growing number of tweets being generated daily, tweet analytics is viewed as one of the fundamental problems of Big data stream. Recently, hashtags, hyperlinked words, in tweets have been applied for tweet retrieval, trend/event detection and advertisement. However, using hashtags for tweet classification remains challenging because we have to cope with context dependent words, slangs, abbreviations, and emoticons with a limited small number of words and an evolving use of hashtags. Most existing approaches deal with classifying tweet sentiments by using the lexicon and meaning of hashtags. Our research aims to classify tweets by topics. Unlike sentiment analytics, hashtags for describing a topic need to be more diverse to cover various aspects of a topic. This paper presents a tweet analytics approach that uses domain-specific knowledge to create a set of strong hashtag predictors for tweet topic classification. The paper describes the approach and preliminary experiments that show promising results toward Big data tweet analytics.
A framework of analysing virtual transfer pricing mechanisms in global supply chain

Supply chain is a network of financial flow while contract is a primary way of recognising and distributing profits between buyer and supplier in a supply chain. Virtual transfer pricing defined in this study is the mechanism of using contract bundles within a global supply chain to maximise profit. We propose three virtual transfer pricing models. The models are articulated with mathematical presentations for clarity. This is one of the first studies to identify basic components of virtual transfer pricing which have significant implications for firms in global supply chains as well as governmental tax agencies all over the world.
Indoor Localization Using 802.11 WiFi and IoT Edge Nodes

The growing affordability and power of the Internet of Things (IoT) technology are enabling researchers to find solutions to problems in all aspects of life. One of these applications is health-care facilities where medical doctors and other medical staff members are in an environment that often needs to locate at moments a patient or other health specialists. In this paper, we propose a solution for the Localization of health Center Assets Through an IoT Environment (LoCATE) system, which allows tracking patients and medical staff in near real time. LoCATE makes use of the current 802.11 wireless networks within a health-care facility and edge node technology as its tracking technique. The edge nodes continuously communicate with the infrastructure's wireless network Access Points (APs)in a nonintrusive manner. The data, collected from the APs by the edge nodes, is processed by a calculation algorithm based on the signal strength to locate the person in possession of the edge node within a reasonable range of variability. We also address privacy and security concerns regarding the system and the proposed solution. Our solution shows accuracy and reliability in locating the nodes as well as cost efficiency and ease of protability.
Comparison of Muscle Activity Using Unstable Devices During a Forward Lunge.

Context:Unstable devices in various forms are used as therapeutic adjuncts for prevention or following an injury. A slip-over-shoe design with inflatable domes (STEPRIGHT® Stability Trainer) was de...
Do some carriers of hemochromatosis gene mutations have higher than normal rates of disease and death

Some heterozygote carriers of hemochromatosis HFE gene mutations become iron loaded with ensuing increased risk of disease and premature death. Contributing nutritional, behavioral and genetic factors are beginning to be identified. Carriers of HFE gene mutations should be advised to minimize contributing factors, if possible, and to have their iron values tested periodically. If values begin to rise, a schedule of phlebotomies should be considered.
Design, implementation, and application of GPU-based Java bytecode interpreters

We present the design and implementation of GVM, the first system for executing Java bytecode entirely on GPUs. GVM is ideal for applications that execute a large number of short-living tasks, which share a significant fraction of their codebase and have similar execution time. GVM uses novel algorithms, scheduling, and data layout techniques to adapt to the massively parallel programming and execution model of GPUs. We apply GVM to generate and execute tests for Java projects. First, we implement a sequence-based test generation on top of GVM and design novel algorithms to avoid redundant test sequences. Second, we use GVM to execute randomly generated test cases. We evaluate GVM by comparing it with two existing Java bytecode interpreters (Oracle JVM and Java Pathfinder), as well as with the Oracle JVM with just-in-time (JIT) compiler, which has been engineered and optimized for over twenty years. Our evaluation shows that sequence-based test generation on GVM outperforms both Java Pathfinder and Oracle JVM interpreter. Additionally, our results show that GVM performs as well as running our parallel sequence-based test generation algorithm using JVM with JIT with many CPU threads. Furthermore, our evaluation on several classes from open-source projects shows that executing randomly generated tests on GVM outperforms sequential execution on JVM interpreter and JVM with JIT.
The Psychotherapy Supervisor as an Agent of Transformation: To Anchor and Educate, Facilitate and Emancipate

Objective:The objective of this review was to answer the question, What do supervisors actually do in promoting transformative change in the beginning therapist supervisee? New therapist trainees, ...
A comparative study of thermal- and electrocatalytic conversion of furfural: methylfuran as a primary and major product

Controlling reaction selectivity represents a fundamental challenge in heterogeneous catalysis. Here, we compare the selectivity in aqueous-phase thermal catalytic and electrocatalytic conversion of furfural and report the fundamental difference in elementary steps in the two reaction systems. Specifically, we observed that furfural alcohol and 2-methylfuran, which is the hydrogenation and hydrogenolysis product of furfural, respectively, are both primary products in electrocatalysis over a Cu electrode, with 2-methylfuran dominating the product distribution under electrode potentials between − 0.55 and − 0.75 V versus RHE. By contrast, in an aqueous-phase thermal reaction using a SiO2-supported Cu catalyst, furfural alcohol and its derivatives from the ring-rearrangement reaction are the major products, without production of 2-methylfuran, at the reaction temperature between 140 and 200 °C. We propose that the distinct selectivity trends for oxygenate conversion via thermal and electrocatalytic reduction result from the distinct sequence of proton attack to the aldehyde group and may be generally true for reduction reactions of other biomass-derived oxygenates.
Evaluating the moderating impact of family on the relationship between board independence and corporate social responsibility using propensity score matching

Purpose: Owing to the voluntary nature of CSR activities, the decision to participate or not could be affected by the motives of corporate directors. The purpose of this research was to investigate whether family involvement in business moderates the relationship between board independence and sustainability performance of firms. Design/methodology/approach: Firstly, propensity score matching is employed to control for the problem of potential endogeneity in the sample by generating a matched sample. Later, regression analysis is conducted on this matched sample to check for the moderating impact of family-led firms on the relation between board independence and CSR performance (CSRP) of firms. Findings/results: We document about Chinese firms with independent boards exhibiting socially responsible behaviour which shows that they serve in a monitoring capacity over the management on behalf of rest of the stakeholders. Moreover, our results show that the role of independent directors is compromised in establishing effective monitoring in family-led firms. Practical implications: Our results would help regulating agencies in designing regulatory programs by guiding them in developing customized policies for different governance and ownership systems in place. Our findings recommend that in a bid to attain improved sustainability performance, diversified shareholding may be favoured or requisite codes may be framed to enhance the social performance of firms having concentrated ownership. Originality/value: This work essentially clears the varying results in literature with regard to the relationship of board characteristics and firms’ CSRP.
Does reporting position affect the pricing of the volatility of comprehensive income

The FASB changed the reporting policy for comprehensive income (CI) by issuing ASU No. 2011‐05, which requires CI be reported in performance statements (i.e., either a single income statement with net income or a separate statement of CI following the income statement) rather than the previously allowed equity statements. We examine whether the change in reporting position of CI led to higher market pricing of CI volatility incremental to NI volatility (“incremental CI volatility”), as measured by the price‐earnings relationship. We find that the market pricing of incremental CI volatility increased from the pre‐ to the post‐ASU period for non‐financial firms forced to change the reporting position of CI from equity to performance statements. The increase is more prominent for firms that switched to the income statement than for firms that switched to a separate statement of CI. Further, we find that the increased market pricing of incremental CI volatility translates into lower valuation weights on other comprehensive income.
Groomed for capitalism: biopower and the self-care, self-improvement rituals of adolescence in Bo Burnham’s Eighth Grade and Donald Glover’s Atlanta

Self-care, self-improvement and biopower, as they relate to the commodification of adolescence and the grooming of young people as neoliberal citizens, are the central concerns of this article. For...
Next Generation of Gallery Sharing in VR

The use of digital photo albums, social media posts, and embedded videos connect people closer to their memories. We believe the next generation of visual albums will immerse individuals through modern virtual reality technologies. This paper examines new methods for enhancing photo albums and visual content; achieved in highly interactive and realistic environments where users are presented with interactable frames, 360 imagery, videos, and dynamic exhibits.
Expansion microsopy reveals Plasmodium falciparum blood-stage parasites undergo anaphase with a chromatin bridge in the absence of mini-chromosome maintenance complex binding protein

ABSTRACT Mitosis in the malaria parasite Plasmodium falciparum undergoes closed mitosis, which occurs within an intact nuclear envelope, and differs significantly from its human host. Mitosis is underpinned by the dynamics of microtubules and the nuclear envelope. To date, our ability to study P. falciparum mitosis by microscopy has been hindered by the small size of P. falciparum nuclei. Ultrastructure expansion microscopy (U-ExM) has recently been developed for P. falciparum, allowing visualization of mitosis at the individual nucleus level. Using U-ExM, three intranuclear microtubule structures are observed: hemispindles, mitotic spindles and interpolar spindles. A previous study demonstrated that the mini-chromosome maintenance complex binding-protein (MCMBP) depletion caused abnormal nuclear morphology and microtubule defects. To investigate the role of microtubules following MCMBP depletion and study the nuclear envelope in these parasites, we developed the first nuclear stain enabled by U-ExM in P. falciparum. MCMBP deficient parasites show aberrant hemispindles and mitotic spindles. Moreover, anaphase chromatin bridges, and individual nuclei containing multiple microtubule structures were observed following MCMBP knockdown. Collectively, this study refines our model for the phenotype of MCMBP-deficient parasites and highlights the utility of U-ExM coupled with a nuclear envelope stain for studying mitosis in P. falciparum.
Atmospheric Nitrogen Oxides Emissions from Global Agricultural Soils: Present and Future

Global nitric oxide (NO) emissions to the atmosphere are projected to increase in the coming years with the increased use of synthetic nitrogen fertilizers and fossil fuel combustion. Here, a statistical model (NO_STAT) is developed for characterizing atmospheric NO emissions from agricultural soil sources, and it is compared to the performance of other global and regional NO emissions (e.g., EDGAR and U.S. EPA). The statistical model was developed using a multiple linear regression between NO emission and the physicochemical variables. The model was evaluated for 2012 NO emissions. In comparison to other data sets, the model provides a lower global NO estimate by 59%, (NO_STAT: 0.67 Tg N yr-1; EDGAR: 1.62 Tg N yr-1). We also performed a region-based analysis (U.S., India; and China) using the NO_STAT model. For the U.S., the model produces an estimate that is 47% lower in comparison to EDGAR. Meanwhile, the NO_STAT model estimate for India shows NO emissions 75% lower when compared to other data sets i.e. EDGAR (which is a comprehensive emissions inventory used in global/regional air quality modeling, and therefore, we have refered to it as ‘other data sets’). A lower estimate is also seen for China, where the model estimates NO emissions 82% lower than other data sets. The difference in the global estimates is attributed to the lower estimates in major agricultural countries like China and India. The statistical model captures the spatial distribution of global NO emissions by utilizing a more simplified approach than those used previously. Moreover, the NO_STAT model provides an opportunity to predict future NO emissions in a changing world. We have made a prediction for future (2050) NO emissions from agricultural soils i.e. emissions from agricultural soils may rise to above ~2.3 TgN/yr, based on anticipated future applications of nitrogen to agricultural soils.
Problem Posing as Reformulation and Sense-Making Within Problem Solving

This chapter examines a type of problem posing that has received little attention in the mathematics education literature. Silver (For the Learning of Mathematics 14:19–28, 1994) defined within-solution problem posing as “problem formulation or reformulation [that] occurs within the process of problem solving” (p. 19). Our analysis documents and explains the role that within-solution problem posing plays during problem solving, focusing on episodes of students from two grade levels: (a) Two fourth-grade students solving a multiplication task, and (b) A mathematics education graduate student solving a number array task. Our research examines: (a) How problem posing evolves from the students’ ongoing interpretations of problematic situations, and (b) How these posed problems contribute to the students’ problem solving. The results provide an explanation of how problem posing and problem solving coevolve in the course of solution activity and thus indicate the beneficial role that problem posing can play in the solution of mathematics problems.
Finite element analysis of gas bearings for oil-free turbomachinery

Further advancements in high performance turbomachinery operating at extreme temperatures mandate the development of gas film bearing technology to procure compact units with improved efficiency in an oil-free environment. A novel finite element (FE) procedure to model thin film gas bearings follows. The FE model incorporates a novel class of high order shape functions ensuring computational efficiency and numerical stability even at (infinity) high speed bearing numbers. The method does not rely on cumbersome schemes for evaluation of advection flow terms in the Reynolds equation nor introduces artificial diffusion into the numerical solution. A computational FE program forwards predictions for the static performance and dynamic force coefficients of an externally pressurized gas bearing for ready application to an automotive turbocharger. The predictions show the strong effects of excitation frequency on the dynamic force coefficients and the onset of a hydrodynamic instability at moderately low rotor s...
Association Between Postpartum Substance Use and Depressive Symptoms, Stress, and Social Support in Adolescent Mothers

In Baltimore Maryland pediatricians compared data on 45 adolescents who used alcohol and/or illegal drugs within four months postpartum with data on 63 postpartum adolescents who used neither alcohol nor illegal drugs to examine demographic and obstetrical characteristics and peer group influences of postpartum women who use illegal substances. All the teens had attended the Adolescent Pregnancy and Parenting Program prenatal clinic during July 1989-March 1990. 93% of all the adolescents were African-American. 42% had used illegal drugs and/or alcohol since delivery. The leading substances used included alcohol (31%) and marijuana (14%). Substance users were more likely to be depressed than nonusers (44% vs. 24%; p = 0.02; odds ratio [OR] = 3.3). They also exhibited higher postpartum stress than nonusers (62% vs. 43%; p = 0.04). Substance users were more likely to have a high need for social support than nonusers (62% vs. 44%; p = 0.07). When the researchers controlled for age having friends who use illegal drugs increased the likelihood of substance use 2.8-fold (p = 0.04). Self-reported postpartum cigarette smoking increased the likelihood of illegal drug use 6.7-fold (p < 0.001). The researchers could not determine whether depression and stress predates or result from substance use. These findings show that many postpartum adolescents used alcohol and drugs and that factors associated with alcohol and drug use included postpartum depression stress high need for support and peer group drug use. Based on these findings the pediatricians recommend that their colleagues consider these factors when caring for adolescent mothers.
Structure and function of Escherichia coli formylmethionine transfer RNA: II. Effect of modification of guanosine residues on aminoacyl synthetase recognition

Abstract Guanosine residues in Escherichia coli formylmethionine transfer RNA have been modified by photo-oxidation in the presence of methylene blue. After irradiation to the extent of 50% loss of amino-acid acceptor activity, separation of active and inactive molecules has shown that guanosine rsesidues in the stem adjacent to the dihydrouridine loop and the guanosine at position no. 2 from the 5′ terminus are not required for aminoacylation or transformylation. Active molecules containing these modifications are amino-acylated with a K m threefold higher than that for unmodified tRNA fMet . No change in V max occurs. Modification of a guanosine residue in the small loop joining the anticodon stem and the TΨC stem results in inactivation of methionine acceptor activity. This represents the first experimental evidence that a modification in this region affects the aminoacylation of a tRNA.