cssi/SciSciGPT-SciSciNet huggingface dataset:
Basal and α1-adrenergic-induced activity of minimal rat βMHC promoters in cardiac myocytes requires multiple TEF-1 but not NFAT binding sites

A culture model for cardiac hypertrophy, stimulation of neonatal rat cardiac myocytes by α1-adrenergic agonists, has been used extensively to identify transcription factors that activate genes during cardiac hypertrophy, such as skeletal α-actin, β-myosin heavy chain (βMHC), and B-natriuretic peptide. We used this culture model to further investigate transcription factors regulating the βMHC promoter in cardiac myocytes under basal conditions and during hypertrophy. We found that the rat βMHC promoter contains two other MCAT sites, in addition to the two MCATs reported previously. The four MCAT sites are conserved in some but not all of the mammalian βMHC promoters examined, and all bind TEF-1 but with varying affinity. As assayed by transient transfection into cardiac myocytes, the four MCATs within 348 bp of the transcription start site are required for full activity of the rat βMHC promoter in the absence and presence of the α1-adrenergic agonist phenylephrine (PE). We found that the βMHC promoter also contains a binding site for the NFAT family of transcription factors, which are activated by calcineurin and are implicated in the hypertrophic process. Although this site bound NFAT3 in vitro and has been reported to be required for βMHC promoter activity in slow skeletal muscle, mutation of the site had no effect on basal or on PE-induced activity of the promoter in cardiac myocytes. Our results show that full activity of minimal βMHC promoters in the presence and absence of hypertrophic agents requires multiple MCAT sites but not NFAT-binding sites.
TECHNIQUE TO MAINTAIN SEPARATION OF MANDIBULAR LOOPS IN INTERSTITIAL IMPLANTATION OF HEAD AND NECK TUMORS

Cancers of the floor of the mouth and lower gingiva are treated by an approach combining external radiation treatment and interstitial implant with Iridium-192 radioisotopes. One technique to administer the dose to these areas is a "loop" technique. A major problem in edentulous patients is that the plastic loops housing the Iridium-192 sources slide out of place along the gum, resulting in loss of ideal spacing. When this occurs, dosimetry for the implant generated from localization films prior to loading does not reflect the distribution of dose delivered. To overcome this problem, we have devised polytetrafluoroethylene (PTFE) spacers which, when used between the loops, maintains their correct spacing. An implant technique and the spacers will be described.
MAXIMAL SUBSEMIGROUPS OF LIE GROUPS THAT ARE TOTAL

The major problem with which this paper is concerned is determining criteria that allow one to decide whether the subsemigroup generated by a subset B of a group G is all of G. Motivations for considering this problem arise from at least two sources.
CMOS Distributed Amplifiers With Extended Flat Bandwidth and Improved Input Matching Using Gate Line With Coupled Inductors

This paper presents a state-of-the-art distributed amplifier with coupled inductors in the gate line. The proposed coupled inductors, in conjunction with series-peaking inductors in cascode gain stages, provide bandwidth extension with flat gain response for the amplifier without any additional power consumption. On the other hand, gate-inductor coupling improves the input matching of the amplifier considerably. The detailed analysis and design methodology for the proposed distributed amplifier are presented. The new four-stage distributed amplifier, fabricated using an IBM 0.18-?m complementary-metal-oxide-semiconductor process, achieves a power gain of around 10 dB, input and output return losses better than 16 and 18 dB, respectively, a noise figure of 3.6-4.9 dB, and a power consumption of 21 mW over a 16-GHz flat 1-dB bandwidth. The measured IIP3 of the amplifier is between 0.1 and 3.75 dBm across the entire band.
Signal probability calculations using partial functional manipulation

Signal probability calculations are necessary to determine the random pattern testability of logic circuits. Determination of random pattern testability is necessary for considering the use of weighted or unweighted linear feedback shift registers (LFSRs) as an appropriate testing method. This paper presents an algorithm to accurately and efficiently (both in space and time) calculate signal probabilities (sometimes called syndrome analysis) within digital logic networks. It has the advantage that it uses a new method for signal probability calculations which is typically both fast and accurate, and which has already efficiently produced results for all the ISCAS combinational circuits. >
A 28-GHz inverse class-F power amplifier with coupled-inductor based harmonic impedance modulator

This paper presents a 28 GHz class-F1 power amplifier in 0.13-μm SiGe BiCMOS technology. The PA adopts a coupled-inductor based harmonic impedance modulator in order to terminate 2nd and 3rd harmonic load impedances appropriately for class-F1 operation. The coupled coils essentially provide frequency-dependent inductance that is optimal to resonate out 2nd and 3rd harmonic reactive impedance. The PA achieve 40–42% PAE over 27.5 GHz to 29 GHz, peak 42% PAE at 28 GHz with 50 mW OP-1db power, one of the highest PAEs ever reported in silicon-based PAs. At 6-dB backoff output power, the PAE is as high as 20% Psat is 16.6 dBm. The PA occupies 0.55×0.96 mm2.
Rural Pennsylvania Underemployment And Its Determinants

This paper investigates the impact of age distribution and educational attainment on the level of underemployment in Appalachian regions of the United States. Furthermore, this study shows the similarities and differences at the state and county levels for Pennsylvania. Following the methodology of Price and Wail (2005) linear regression models are used to estimate the marginal impacts of general economic conditions measured by the unemployment rate, as well as age and educational attainment, on the level of underemployment in the state. In rural Appalachia, younger workers and those with some post-baccalaureate education are more likely to find themselves underemployed. Keywords: rural economics, Appalachian studies, unemployment, underemployment, measurement issues.
Air pollution as a cause of heart disease. Time for action.

The environmental controls that have been developed overthe last quarter century have, for the most part, beendesigned to reduce respiratory disease and cancer. In con-trast, public health measures designed to reduce heartdisease have concentrated on individual risk factors (1).Over the last decade, however, there has been growingepidemiological evidence that elevated levels of air pollu-tion, particularly increased levels of ﬁne particulates (smallerthan 10 m in diameter, PM
Where are the Women in Wikipedia? Understanding the Different Psychological Experiences of Men and Women in Wikipedia

A comprehensive survey conducted in 2008 found that only 13 % of Wikipedia contributors are women. We proposed that masculine norms for behavior in Wikipedia, which may be further exacerbated by the disinhibiting nature of an online, anonymous environment, lead to different psychological experiences for women and men, which, in turn, explain gender differences in contribution behavior. We hypothesized that, among a sample of individuals who occasionally contribute to Wikipedia, women would report less confidence in their expertise, more discomfort with editing others’ work, and more negative responses to critical feedback compared to men, all of which are crucial aspects of contributing to Wikipedia. We also hypothesized that gender differences in these psychological experiences would explain women’s lower contribution rate compared to men in this sample. We analyzed data from a sample of 1,598 individuals in the United States who completed the English version of an international survey of Wikipedia users and readers conducted in 2008 and who reported being occasional contributors. Significant gender differences were found in confidence in expertise, discomfort with editing, and response to critical feedback. Women reported less confidence in their expertise, expressed greater discomfort with editing (which typically involves conflict) and reported more negative responses to critical feedback compared to men. Mediation analyses revealed that confidence in expertise and discomfort with editing partially mediated the gender difference in number of articles edited, the standard measure for contribution to Wikipedia. Implications for the gender gap in Wikipedia and in organizations more generally are discussed.
Catalytic synthesis of methanol from COH2: IV. The effects of carbon dioxide

The effects of carbon dioxide on the catalytic synthesis of methanol over the copper-zinc oxide catalysts were investigated for CO2/CO/H2 ratios between 0/30/70 and 30/0/70. A maximum synthesis rate was observed-at CO2/CO/H2 = 2/28/70. At lower concentrations of CO2 the catalyst is deactivated by overreduction and at higher concentrations of CO2 the synthesis is retarded by a strong adsorption of this gas. A kinetic model is presented which quantitatively describes the observed patterns in the indicated range of synthesis gas compositions and at temperatures between 225 and 250 °C. This model is consistent with all physical characteristics of the CuZnO catalysts and corroborates earlier findings that an intermediate oxidation state of the catalyst is its active state. The adsorption enthalpies and entropies for the reactants indicate that carbon dioxide is strongly bound and immobile while carbon monoxide and hydrogen are chemisorbed with intermediate strength and experience a considerable mobility in the adsorbed layer. At concentrations of CO2 greater than 10%, methane is a side product. Mechanistic implications of this finding are that there is a nonselective pathway parallel to the CO hydrogenation; this pathway may involve formate and methoxy intermediates.
Calcineurin Homologous Proteins Regulate the Membrane Localization and Activity of Sodium-Proton Exchangers in C. elegans

Calcineurin B homologous proteins (CHP) are N-myristoylated, EF-hand Ca2+-binding proteins that bind to and regulate Na+/H+ exchangers, which occurs through a variety of mechanisms whose relative s...
Keller Williams Realty (A)

This case is a follow up to Keller Williams (A) HR-29A, and explains the actions taken by Keller Williams in response to the residential real estate market downturn in 2008 and 2009. The case explains the programs and initiatives put in place by the company to boost agent count, increase productivity, and reduce expenses throughout the organization. It also explains how the company relied on these initiatives to not only survive the market downturn but to thrive, achieving success by leveraging the strengths of the company’s operating model, core principles, and values.
Relationship Between Petrographic Characteristics, Engineering Index Properties, and Mechanical Properties of Selected Sandstones

Six different sandstone units were studied to investigate and quantify the relationship between their mechanical properties (compressive strength, tensile strength, Young's modulus, Poisson's ratio), petrographic characteristics, and engineering index properties. Sandstones investigated included the Sharon sandstone, the Juniata sandstone, the Morgantown-Grafton sandstone, and three Berea sandstone units. These sandstones were tested for percent absorption, density, slake durability, total pore volume, uniaxial compressive strength, tensile strength, Young's modulus, and Poisson's ratio. Petrographic characteristics studied included grain size, grain shape, grain sorting, packing density, packing proximity, degree of grain interlocking, and mineral composition. The data were analyzed statistically to determine the quantitative relationships between various properties. Results indicate that compressive strength, tensile strength, and Young's modulus values for the sandstones studied are closely related (r>0.7) to their density, percent absorption, total pore volume, and type of grain-to-grain contacts. Generally, sandstones with higher densities, lower percent absorption, lower total pore volume, and higher percentage of sutured contacts exhibited higher values of compressive strength, tensile strength, and Young's modulus. For Poisson's ratio, however, inverse relationships were observed with compressive strength and Young's modulus. Based on these results, equations were developed for predicting mechanical properties from values of density, percent absorption, total pore volume, and percent sutured contacts.
Evolutionary model for military forces system of systems based on topological weighed networks

In order to explore the laws of informational warfare,the paper improved the method of using Lanchester equations to determine combating capability index,and studied how to introduce complex network theory into the research on military forces SoSs(system of systems).On the basis of analyzing key features of military forces SoSs,this paper abstracted mathematical relations between combat units,simulated their dynamic evolution by means of weighed topology model and obtained an evolutionary model for the SoSs,which is consistent with real data.Through simulation,this paper draws the conclusion that military forces SoSs has the character of self-similarity which is reflected with the power law,also has a fractal structure.To apply this model to auxiliary operational analysis,the paper extended the synchronixing capability of weighted net to the operational capability of the SoSs and achieved good results.
Symbolic construction of GR(1) contracts for systems with full information

This work proposes a symbolic algorithm for the construction of assume-guarantee specifications that allow multiple agents to cooperate. Each agent is assigned goals expressed in a fragment of linear temporal logic known as generalized Streett with one pair, GR(1). These goals may be unrealizable, unless each agent makes additional assumptions, about the behavior of other agents. The algorithm constructs a contract among the agents, in that only the infinite behavior of the given goals is constrained, known as liveness, not the finite one, known as safety. This defers synthesis to a later stage of refinement, modularizing the design process. We prove that there exist GR(1) games that do not admit any refining GR(1) contract. For this reason, we formulate contracts with nested GR(1) properties and auxiliary communication variables, and prove that they always exist. The algorithm's fixpoint structure is similar to GR(1) synthesis, enjoying time complexity polynomial in the number of states, and linear in number of recurrence goals.
Establishment of reference ranges and evaluation of in vitro concentration-dependent platelet inhibition by acetylsalicylic acid for multiple electrode impedance aggregometry in healthy dogs.

Acetylsalicylic acid (ASA, aspirin) is an antiplatelet medication used for prevention of thromboembolism. Effects of ASA appear to vary widely between dogs, but the underlying mechanisms are not understood. The Multiplate analyzer is a newer form of whole-blood impedance aggregometry recently validated for use in healthy dogs. A method utilizing this instrument to measure ASA effects on platelet function has not been established. The goals of this study were to establish reference ranges for the Multiplate in healthy dogs and secondly, to develop a technique to determine the in vitro concentration of ASA needed to cause 50% inhibition of platelet aggregation (IC50). Reference ranges established from 40 dogs at multiple test times for three agonists were consistent with previously published values. In vitro IC50 values were calculated using the sigmoid Emax model in 20 healthy dogs on two occasions to determine individual repeatability. Calculated in vitro IC50 demonstrated four ASA response groups: responder (n = 16), poor responder (n = 1), variable responder (n = 2), and nonresponder (n = 1). Multiplate within-assay variability was <10% for area under the curve (AUC), and between-assay baseline AUC variability was <15%. The described technique allowed for determination of an in vitro IC50 for ASA in dogs using a multiple electrode impedance aggregometer.
Oral History and Digital Humanities: Voices, Access, and Engagement. Douglas A. Boyd and Mary A. Larson (eds.)

Douglas Boyd and Mary Larson have edited a very useful collection of essays that reflect on the intersection of oral history and digital methods. The editors turn to The Digital Humanities Manifest...
Surgical Treatment of Atypical Mycobacterial Disease: A Survey of Experience in Veterans Administration Hospitals

Nine Veterans Administration hospitals reported every patient with pulmonary disease caused by atypical mycobacteria who had been treated surgically between January 1, 1958, and June 30, 1963. Ninety-eight patients had 101 surgical procedures during this period. Major complications related to the acid-fast disease occurred in 9 per cent, one of which resulted in death, a surgical mortality of 1 per cent. Good results were obtained in 94 per cent. There were two late, unrelated deaths, and late bacteriologic relapse occurred in five patients. Surgical intervention in patients with pulmonary disease caused by mycobacteria other than M. tuberculosis has been demonstrated to be safe. Although the role of surgery cannot be stated with finality, it clearly has the capabilities of making a major contribution toward the early rehabilitation of these patients, when skillfully performed in properly selected patients.
Interviewer Deviations from Scripts

There are at least two different scripts that are involved in the standardized survey interview. One is the script of the survey questions themselves, and the other is the script of the rules of standardization. This section discusses both scripts in various ways by describing some studies that might be thought provoking as a way of thinking about some of the issues raised by how these scripts are used by interviewers.
Targeting the Tumor Microenvironment with Immunotherapy for Genitourinary Malignancies.

Bacillus Calmette-Guerin in urothelial carcinoma, high-dose interleukin-2 in renal cell carcinoma, and sipuleucel-T in prostate cancer serve as enduring examples that the host immune response can be harnessed to promote effective anti-tumor immunity in genitourinary malignancies. Recently, cancer immunotherapy with immune checkpoint inhibitors has transformed the prognostic landscape leading to durable responses in a subset of urothelial carcinoma and renal cell carcinoma patients with traditionally poor prognosis. Despite this success, many patients fail to respond to immune checkpoint inhibitors and progression/relapse remains common. Furthermore, modest clinical activity has been observed with ICIs as a monotherapy in advanced PCa. As such, novel treatment approaches are warranted and improved biomarkers for patient selection and treatment response are desperately needed. Future efforts should focus on exploring synergistic and rational combinations that safely and effectively boost response rates and survival in genitourinary malignancies. Specific areas of interest include (1) evaluating the optimal sequencing, disease burden, and timing of immuno-oncology agents with other anti-cancer therapeutics and (2) validating novel biomarkers of response to immunotherapy to optimize patient selection and to identify individuals most likely to benefit from immunotherapy across the heterogenous spectrum of genitourinary malignancies.
Organizing Genius: The Secrets of Creative Collaboration

(1999). Organizing Genius: The Secrets of Creative Collaboration. Quality Management Journal: Vol. 6, No. 1, pp. 80-83.
Examining the association between adiposity and biochemical recurrence after radical prostatectomy.

Introduction: Herein, we examined the association between adiposity, as measured by computed tomography (CT), and biochemical recurrence (BCR) after radical prostatectomy (RP). Methods: Using axial CT images, preoperative fat mass index (FMI) was calculated for 698 men who underwent RP from 2007–2010 by using measurements of total surface area of adipose tissue at the L3 level. Obesity was classified according to National Health and Nutrition Examination Survey (NHANES) standards for obesity (FMI >9 kg/m2). The associations between obesity and the distribution of adiposity (visceral vs. subcutaneous) with BCR were examined using the Kaplan-Meier method and Cox proportional hazards regression analyses. Results: Obese men were older than non-obese men (63.0 vs. 60.7 years; p 0.05) in multivariable analyses. Conclusions: Neither total abdominal adiposity nor the distribution of adiposity were independently associated with BCR after RP in this study. As such, the presence of obesity may not be a marker of increased oncological risk after RP.
Pourfour du Petit Syndrome in an Acute Top of the Basilar Artery Stroke (P4.344)

Objective: Pourfour du Petit syndrome (PdP) is an extraordinarily unusual clinical condition produced by oculosympathetic hyperactivity. It is characterized by the unilateral appearance of mydriasis, lid retraction and exophthalmos. It is named after a French anatomist and ophthalmologist who was also the first one to identify clinical symptoms of what is now known as Horner’s Syndrome Background: NA Design/Methods: NA Results: Patient was a 70 year old female who presented to hospital after being found unresponsive. Neurologic exam was significant for obtunded patient with bilateral ptosis, unreactive pupils with intact brain stem reflexes and withdrawing to painful stimulus. MRI brain revealed acute infarcts in bilateral thalami with extension to the cerebral peduncles and central midbrain along with right cerebellum and right occipital lobe. During hospital stay, she was noticed developing symptoms of sympathetic storming. This was particularly vivid on physical stimulation-the patient had episodes of dilatation of bilateral pupils along with hyperhidrosis and agitation with upper extremity movements. These episodes were controlled with addition of clonidine with good outcome. Conclusions: PdP syndrome has previously described in injuries to cervical sympathetic chain and brachial plexus, post-traumatic syringomyelia, aortic malformation, thoracic, esophageal and lung carcinoma and maxillofacial surgery. We had interesting dilemma where she had bilateral complete third nerve palsy from a basilar artery stroke affecting the midbrain. She was noted to periods of sympathetic hyperactivity and this seemed to be extremely pronounced especially as the parasympathetic activity was lost. Our hypothesis is that the occurrence of periods of sympathetic over activity associated with bilateral mydriasis and hyperhidrosis is similar to picture observed with PdP syndrome albiet now being caused by a central lesion. Neurologists should be aware about PdP syndrome which is a reverse Horner’s Syndrome and its etiologies to help localize the lesion. Disclosure: Dr. Nurmukhamedov has nothing to disclose. Dr. Rakhesh has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Culebras has nothing to disclose.
Relationships among Learning Styles and Motivation with Computer-Aided Instruction in an Agronomy Course.

Multi-media learning tools were developed to enhance student learning for an introductory agronomy course at Iowa State University. During fall 2002, the new interactive computer program, called Computer Interactive Multimedia Program for Learning Enhancement (CIMPLE) was incorporated into the teaching, learning, and assessment processes of the introductory course. At the end of the course, students completed (i) a Kolb’s Learning Style Inventory, and (ii) a survey designed to record the students’ use, satisfaction, and motivation to use CIMPLE. Learning outcomes were assessed using course grades. No statistically significant differences existed in CIMPLE use pattern among Kolb’s five Learning Styles as students from each of these learning styles tended to use the seven components of CIMPLE about the same number of times. However, students who had a converging learning style tended to have the highest grades while students who were accommodators had the lowest grades. There was a significant positive correlation between student’s motivation to use CIMPLE and the use of several components of CIMPLE, including chapter assessment, video, key concepts, practice, self-check, and environmental and ethical issues. Of the seven components of CIMPLE, only chapter assessment and environmental and ethical issues showed a significant correlation with student’s final semester grades. This research is significant in demonstrating that computer-aided instruction can be designed to appeal to students across all learning styles. Further, this research demonstrates a connection between students’ motivation to use instructional technology and the frequency of using the technology, and offers suggestions of ways to increase use and motivation of technology to improve learning outcomes.
From introduction to operating systems to computer architecture: does an online prerequisite course prepare students better?

Online courses are becoming more and more popular in postsecondary education, including computer science (CS) departments. However, there are conflicting reports in the literature regarding whether online course delivery results in equivalent, better, or worse learning achievement for the students. A previous study of student performance in an Introduction to Operating Systems course that was converted from a face-to-face lecture class to online delivery showed some improvement in performance on tests after the course went online; however, the results were not sufficient to establish statistical significance. The current study considers the same two sets of students, but compares their performance in a subsequent face-to-face course (Computer Architecture) for which the operating systems course was a prerequisite. Analysis of test and final exam scores in the Computer Architecture course reveals that students who took the prerequisite course online performed significantly better than those who took it face-to-face. This result supports further development of online courses, particularly lower-level prerequisite courses, within the computer science curriculum.
Probing Coherent Vibrations of Organic Phosphonate Radical Cations with Femtosecond Time-Resolved Mass Spectrometry

Organic phosphates and phosphonates are present in a number of cellular components that can be damaged by exposure to ionizing radiation. This work reports femtosecond time-resolved mass spectrometry (FTRMS) studies of three organic phosphonate radical cations that model the DNA sugar-phosphate backbone: dimethyl methylphosphonate (DMMP), diethyl methylphosphonate (DEMP), and diisopropyl methylphosphonate (DIMP). Upon ionization, each molecular radical cation exhibits unique oscillatory dynamics in its ion yields resulting from coherent vibrational excitation. DMMP has particularly well-resolved 45 fs ( 732 ± 28 cm − 1 ) oscillations with a weak feature at 610–650 cm − 1 , while DIMP exhibits bimodal oscillations with a period of ∼55 fs and two frequency features at 554 ± 28 and 670–720 cm − 1 . In contrast, the oscillations in DEMP decay too rapidly for effective resolution. The low- and high-frequency oscillations in DMMP and DIMP are assigned to coherent excitation of the symmetric O–P–O bend and P–C stretch, respectively. The observation of the same ionization-induced coherently excited vibrations in related molecules suggests a possible common excitation pathway in ionized organophosphorus compounds of biological relevance, while the distinct oscillatory dynamics in each molecule points to the potential use of FTRMS to distinguish among fragment ions produced by related molecules.
Fermi-level Dirac crossings in 4 d and 5 d cubic metal oxides: NaPd 3 O 4 and NaPt 3 O 4

The cubic oxide metals $\mathrm{Na}{M}_{3}{\mathrm{O}}_{4}$ ($M=\mathrm{Pd}$ or Pt) crystallize in the nonsymmorphic $Pm\overline{3}n$ space group. First-principles calculations are employed here to understand the role of the $M{\mathrm{O}}_{4}$ square planes and $M\ensuremath{-}M$ interactions in the development of the electronic structure. The compounds host numerous Dirac crossings near the Fermi level which, in the absence of spin-orbit coupling, appear to form a cubic nodal state. Spin-orbit coupling fragments this nodal state into smaller regions with Dirac-like character, with the fragmenting being more pronounced in the $M=\mathrm{Pt}$ compound.
Investigating Contemplative Practice in Creative Writing and Education Classes: A Play (of Practice and Theory) in Three Acts

Scene One, The Meeting Creation comes from an impulse and an urge. November 2006, Washington D.C., ISSOTL pre-conference Carnegie Leadership Program meeting. I sit at one end of a long table in the Washington Hilton Hotel, facing a window that reveals the dome of the nation’s capitol. Patti Owen-Smith leads a meeting of the Cognitive Affective Learning (CAL) Group. We talk definitions, action plans, meeting dates. At the other end sits Maureen Hall. She and I have never met until this meeting. But we slowly connect with each other as the day progresses, a connection developed through an imperceptible filament across the long table as each of us occasionally contributes to the group’s discussion. Later when we discuss this connection, she will recall my comments on feminist theory at the meeting. I will remember Maureen’s reference to Mary Rose O’Reilley, a writer significant to both of us.
Re-Evaluating Yourself

While setting goals is important, it is also important to reflect on your true “long-term vision statement.” Understanding how you have changed is important, so that you can better focus as your value system and strategy. There is no more powerful learning tool than close observation of high performing people, or people you hope to emulate. Jump at opportunities to work with your system leadership, it will get you the added benefit of observing the leadership closely, seeing how they formulate a plan, strategy for that plan, and watch the subsequent execution. Ongoing development can be vital, and helpful, but pursuing this in a busy time in your career is challenging. As you become more senior, and more skilled, you can buy time and take courses or take a personal or group retreat to recharge. Most of us do not do this enough, and this can be very helpful. Time is the most precious commodity we have, and generally urologists do not lack for salary, unless other circumstances more personal than professional have intervened. The ability to change is a “superpower.” There is nothing more difficult than to change. Old school values, such as hard work, blind passion, intense loyalty, may sound good but are far from modern or as relevant as in the past. Ego and respect are also problematic values. No matter who you are, leave your ego at the door whenever possible. Respect is more complicated. You can seek respect, but in the end you earn respect, most likely every day, every hour. We work in a hierarchical environment, of rank, or full partner status in the practice setting. While important at many levels, the “privileges of membership” can be the source of serious indiscretions. Again, the emphasis must be on self-improvement, moving forward, and adapting to, not living on past accomplishments and times. So how do you learn to adapt? Knowing yourself is key, as you may think you are adapting when actually you are not. Ask others, watch others, and mentor others with interest. With time, you can learn a lot from your mentees and in the end, continue to refine your approach to best meet the needs of your team. Finally, adaptation requires study. Those who can adapt are the “ultimate students,” who keep getting better against the odds.
Single-molecule nanoscale drug carriers with quantitative supramolecular loading

While there are examples of successful nanomedicine technologies, challenges remain in engineering systems with controlled and defined characteristics such as size and drug loading. Dendrimers are a class of synthetic macromolecules which offer routes to precise nanoscale objects. Here, highly efficient and orthogonal methods for dendrimer synthesis are combined with the covalent attachment of a tunable number of cucurbit[7]uril macrocycle carriers. This synthetic macrocycle affords uniquely high-affinity binding to certain guests, lending modularity to the prepared dendrimer in terms of its drug cargo. To verify this concept, the chemotherapeutic doxorubicin was conjugated to a high-affinity guest for CB[7]. When combined with CB[7]-modified dendrimers, quantitative drug loading was realized, with one drug bound per CB[7] on the dendrimer. The guest-modified drug was attached via a pH-labile linker to facilitate release at sites of disease or upon cell internalization. This approach offers a new combination of discrete and efficient synthetic methodology coupled with modular and high-affinity supramolecular motifs to engineer platforms with exceptional precision for use in drug delivery.
Management-intensive Grazing Affects Soil Health

Abstract. Management-intensive Grazing (MiG) on irrigated, perennial pastures has steadily increased in the western US due to pressure for reducing public lands grazing, overall declining land available for pasture, and decreasing commodity prices. However, there are still many unknowns regarding MiG and its environmental impact, especially with regards to soil health. Over a two-year period, we studied changes in soil health under a full-scale, 82 ha pivot-irrigated perennial pasture system grazed with ~ 230 animal units (AUs) using MiG. Soil analysis included 11 soil characteristics aggregated into the Soil Management Assessment Framework (SMAF), which outputs results for soil biological, physical, nutrient, chemical, and overall soil health indices (SHI). Positive impacts were observed in the biological SHI due to increases in microbial and enzymatic activities, even though soil organic C (SOC) remained relatively unchanged; however, positive biological SHI changes are likely precursors to future SOC increases. The nutrient SHI declined due to a reduction in plant-available soil P over time, potentially due to greater plant uptake. A negative impact was also observed in the physical SHI, driven primarily by increasing bulk density due to hoof pressure from cattle grazing. If managed correctly, results suggest that irrigated, MiG systems have the potential for success with regards to supporting grazing while promoting soil health for environmental and economic sustainability.
An Interprofessional Team Performance Training Program for the Care of Vulnerable Patients in the Ambulatory Setting

Abstract Health professions trainees often want to care for vulnerable populations, but their good intentions can be tested by patients’ complex medical, psychological, and social needs. Well-functioning care teams can respond to these challenges through communication, coordination and supportive relationships, but this requires teams to train together. In this paper, we describe a year-long ambulatory curriculum that trains post-graduate primary care and mental health trainees in key aspects of teamwork and relationship-centered care as they care for patients with complex biopsychosocial problems. The curriculum was developed and implemented with two cohorts of trainees from primary care, mental health and pharmacy disciplines (n =31) that were immersed in an interprofessional team caring for homeless Veterans in a patient-centered medical home (PCMH). Our curriculum is relevant for any clinical site seeking to improve team-based care for patients with complex conditions. It is grounded in an evidence-derived team performance framework that addresses three key aspects of well-performing teams: meeting practices (standardizing time and processes for collaborative care using checklists), taskwork (understanding team members' roles and responsibilities, and how to improve care), and teamwork (building humanistic relationships with patients and team members, and communicating respectfully). The curriculum is experiential and requires trainees to work on an existing patient care team and participate in team-based care processes (e.g. huddles, team meetings, panel management). We address stakeholder engagement, faculty and team development, culture building and logistics. Using two previously validated instruments to assess trainee perceptions of team performance and personal burnout at 6 and 12 months, we found that the program led to improvements in trainees’ perspectives of team performance, their relationship skills, and the effectiveness of their meeting practices, while also avoiding burnout. Key factors contributing to the success of the program are co-locating the professions, faculty role-modeling of team practice and communication behaviors, promotion of a relationship-centered culture, regularly scheduled workplace learning activities and planned IP learning sessions that support team-based practice.
Deep Kernel Learning-Based Channel Estimation in Ultra-Massive MIMO Communications at 0.06-10 THz

The abundant spectrum resources at the millimeter wave (mm-wave) and Terahertz band (0.06-10 THz) are promising to enable a new paradigm shift in wireless communications to satisfy the demand for higher data rates in the beyond 5G era. Due to limitations of very high propagation attenuations and molecular absorptions at such high frequencies, ultra-massive MIMO (UM MIMO) communications are needed to compensate for the distance limitations, propagation losses, and to achieve higher spatial diversity. However, existing channel estimation algorithms for massive MIMO solutions require excessive computation time and demonstrate high processing complexities, whereas the problem is escalated more when the antenna array size continues to grow in the UM MIMO system. In this paper, a channel estimation method based on deep kernel learning is proposed to address the issues with estimation efficiency and accuracy in the UM MIMO communication system. This nonlinear estimation algorithm is shown to be more efficient compared to classic linear estimation approaches. A numerical comparison is conducted through simulations to show the performance of the proposed solution.
High-fat-diet induced obesity increases the proportion of linoleic acyl residues in dam serum and milk and in suckling neonate circulation.

Maternal obesity increases the risk of offspring to become obese and develop related pathologies. Exposure to maternal high-fat diet (HFD) only during lactation increases the risk of obesity-related diseases, suggesting that factors in milk affect long-term health. We hypothesized that prepregnancy obesity induced by HFD alters milk lipidome, and in turn, alterations may affect neonate serum lipidome. The objective of this study was to determine the effect of prepregnancy obesity induced by HFD on circulating lipids in dams and neonates and in milk. Female mice were fed an HFD (60% kcal fat) or control diet (CON, 10% kcal fat) beginning 4 weeks before breeding. On postnatal day 2 (PND2), pups were cross-fostered to create pup groups exposed to HFD during pregnancy, lactation, or both or exposed to CON. On PND12, dams were milked and then euthanized along with pups to collect blood. Serum and milk were processed for multiple reaction monitoring (MRM) lipidomics profiling to quantify the relative expression of lipid classes. Lipidome of HFD dam serum and milk had increased proportion of C18:2 free fatty acid and fatty acyl residues in all lipid classes. Lipidome of serum from pups exposed to maternal HFD during lactation was similarly affected. Thus, maternal HFD induced redistribution of fatty acyl residues in the dam's circulation, which was associated with modification in milk and suckling neonate's lipidome. Further studies are needed to determine if increased circulating levels of C18:2 in neonate affects development and predisposes offspring to obesity and metabolic syndrome.Graphical AbstractSummary SentenceMaternal prepregnancy obesity induced by high-fat diet significantly impacts circulating lipids and similarly modifies the lipid composition of milk and circulating lipid of suckling neonates.
Measuring the Adiabatic Ignition Delay of n-Pentane Mixture using Rapid Compression Machine

Recent combustion research has focused on low temperature combustion to meet engine emission regulations and to advance the development of low temperature homogenous compression ignition engines. Autoignition studies in this temperature regime are primarily performed by Rapid Compression Machines (RCMs) which are sensitive to the heat transfer characteristics of the experimental device. RCMs are widely used to measure autoignition data such as ignition delay and species concentration. Measured ignition delays from RCMs are typically reported at an adiabatic condition; however, this assumption may produce a systematic error in ignition delay measurement as heat transfer is observed to reduce the pressure and temperature during the autoignition process, e.g., a longer ignition delay has a greater pressure and temperature drops. RCMs are custom built and have unique design characteristics that affect the heat transfer during the autoignition process. In addition, depending on the diluent composition (e.g., helium versus nitrogen or argon), different heat transfer characteristics are expected. As a result, autoignition results at similar conditions may vary from facility to facility or depending on the used diluent. The dependency of the measured data on the used facility or diluent may produce uncertainty in the data which impact the development of high-fidelity combustion mechanisms. In this work, a new method is developed and utilized to eliminate heat transfer from the ignition delay data. To evaluate the new method, the autoignition of n-pentane mixtures in the low temperature regime were investigated using an RCM. To vary the heat transfer, the compression ratio of the RCM was changed and the ignition delays were measured at similar pressure and temperature conditions. The tests were performed at an equivalence ratio of approximately one and nitrogen and argon as diluents. By applying the new method, the effect of heat transfer on the ignition delays were eliminated successfully and ignition delays at adiabatic condition were determined. A detailed kinetic model of n-pentane was used to simulate the measured adiabatic ignition delay, which agreed well with the experimental data.
Capsular distention for adhesive capsulitis in a pediatric patient with acute flaccid myelitis: A case report.

Introduction Acute Flaccid Myelitis (AFM) is a recently recognized pediatric condition characterized by flaccid paralysis that can cause lifelong deficits. Adhesive Capsulitis (AC) is a chronic condition that causes loss of passive range of motion in the shoulder due to joint contracture. Case report This is a case report of a 15-year-old male who suffered from shoulder pain with progressive loss of passive range of motion after AFM, diagnosed with AC based on exam and radiology. After failing conservative management, the patient was successfully treated with ultrasound guided corticosteroid injection. Discussion/conclusion AC is uncommonly reported in pediatric patients. However, secondary adhesive capsulitis is frequently associated with disorders of shoulder immobility in adults. This case contributes to the body of literature regarding pediatric frozen shoulder, highlights the successful use of ultrasound guided injections for management, and suggests a relationship between AFM and AC which may be beneficial for pediatric physiatrists in treating patients with shoulder pain or immobility related to this condition.
COVID-19 Is Having a Devastating Impact on the Economic Well-being of Latino Families

Latino Americans are more likely than non-Hispanic whites to contract COVID-19 and to face disproportionately high mortality rates when they contract the virus. What has not been well understood is the impact COVID-19 is having on the economic well-being of Latino families. Using the Abriendo Puertas/Latino Decisions National Parent Survey (1195), we asked Latino respondents how the pandemic has impacted their employment, savings, and finances and we also asked them how they have been coping to make ends meet. Using descriptive analysis and ordinal least squares regression, we find that Latinos are experiencing high job loss and business closures. We also find that young parents (18–29-year olds) and those with income levels of $25,000 or lower are experiencing the most economic stress. We also find that Latinos are having difficulty making housing payments and postponing educational and health-related services to make ends meet. We also find that just over half of Latinos have emergency savings under $1000 which is important given that unemployment benefits expired on July 31, 2020. In conclusion, this research finds that Latinos are experiencing economic stressors and are engaging in coping strategies that are deeply concerning and which require explicit attention from policymakers. Given that Latinos took the longest to recover from the Great Recession, policymakers should keep this in mind as we continue to monitor the implications of the recession, ideally looking at mechanisms to reduce the stress for Latino families and encourage policies which target low-income working class Americans and small business owners.
Growth Opportunities for the American Worker: Hottest Growth Industries by Decade 1890-2020

Manufacturing. Energy. Agriculture. In 1900, these were the industries of a still-young nation establishing itself as an emerging world power. Today, a century of accumulated innovation is creating new pathways of industrial advancement that would have been impossible to imagine a century ago. These industries are re-emerging in new forms, leading a transformation of the American economy. This report seeks insight into the next decade of America’s economic evolution by revisiting 10 prior decades of industrial change. Taken together, the data-derived vignettes in this report tell the story of a nation’s ascent—despite a Great Depression and two world wars—and o er glimpses of some of the thousands of innovations that, cumulatively, made such an ascent possible. More than anything, the 20th century was about the rise and partial fall of production at scale. From the 1910s to the 1970s, one industry after another went from small and decentralized to large and concentrated. Craftsmanship yielded to machinery, and tinkering gave way to managerial e ciency. By the 1980s, however, investors began to lose interest in corporate conglomerates. America’s culture of entrepreneurship reasserted itself. A revolution in information and communications technologies swept through one industry after another. A surge in globalized exchange disrupted industrial practices of the middle of the century. The recent recession has done little to alter the arc of history, and future pathways of progress appear to be following the same trajectory as the country’s previous industrial ascent. Today, the United States is 4 times more populous and more than 30 times more prosperous than it was a century ago, and patterns of industrial evolution point to a period of large-scale economic renewal.