cssi/SciSciGPT-SciSciNet huggingface dataset:
Noodles: A Tool for Visualization of Numerical Weather Model Ensemble Uncertainty

Numerical weather prediction ensembles are routinely used for operational weather forecasting. The members of these ensembles are individual simulations with either slightly perturbed initial conditions or different model parameterizations, or occasionally both. Multi-member ensemble output is usually large, multivariate, and challenging to interpret interactively. Forecast meteorologists are interested in understanding the uncertainties associated with numerical weather prediction; specifically variability between the ensemble members. Currently, visualization of ensemble members is mostly accomplished through spaghetti plots of a single midtroposphere pressure surface height contour. In order to explore new uncertainty visualization methods, the Weather Research and Forecasting (WRF) model was used to create a 48-hour, 18 member parameterization ensemble of the 13 March 1993 "Superstorm". A tool was designed to interactively explore the ensemble uncertainty of three important weather variables: water-vapor mixing ratio, perturbation potential temperature, and perturbation pressure. Uncertainty was quantified using individual ensemble member standard deviation, inter-quartile range, and the width of the 95% confidence interval. Bootstrapping was employed to overcome the dependence on normality in the uncertainty metrics. A coordinated view of ribbon and glyph-based uncertainty visualization, spaghetti plots, iso-pressure colormaps, and data transect plots was provided to two meteorologists for expert evaluation. They found it useful in assessing uncertainty in the data, especially in finding outliers in the ensemble run and therefore avoiding the WRF parameterizations that lead to these outliers. Additionally, the meteorologists could identify spatial regions where the uncertainty was significantly high, allowing for identification of poorly simulated storm environments and physical interpretation of these model issues.
Fault detection and isolation in aircraft gas turbine engines. Part 2: Validation on a simulation test bed

The first part of this two-part paper, which is a companion paper, has developed a novel concept of fault detection and isolation (FDI) in aircraft gas turbine engines. The FDI algorithms are built upon the statistical pattern recognition method of symbolic dynamic filtering (SDF) that is especially suited for real-time detection and isolation of slowly evolving anomalies in engine components, in addition to abrupt faults. The FDI methodology is based on the analysis of time series data of available sensors and/or analytically derived variables in the gas path dynamics. The current paper, which is the second of two parts, validates the algorithms of FDI, formulated in the first part, on a simulation test bed. The test bed is built upon an integrated model of a generic two-spool turbofan aircraft gas turbine engine including the engine control system.
Anti-Borrelia burgdorferi Antibody Profile in Post-Lyme Disease Syndrome

Patients with post-Lyme disease syndrome (PLDS) report persistent symptoms of pain, fatigue, and/or concentration and memory disturbances despite antibiotic treatment for Lyme borreliosis. The etiopathogenesis of these symptoms remains unknown and no effective therapies have been identified. We sought to examine the antiborrelia antibody profile in affected patients with the aim of finding clues to the mechanism of the syndrome and its relationship to the original spirochetal infection. Serum specimens from 54 borrelia-seropositive PLDS patients were examined for antibodies to Borrelia burgdorferi proteins p18, p25, p28, p30, p31, p34, p39, p41, p45, p58, p66, p93, and VlsE by automated immunoblotting and software-assisted band analysis. The presence of serum antibodies to the 31-kDa band was further investigated by examination of reactivity against purified recombinant OspA protein. Control specimens included sera from 14 borrelia-seropositive individuals with a history of early localized or disseminated Lyme disease who were symptom free (post-Lyme healthy group), as well as 20 healthy individuals without serologic evidence or history of Lyme disease. In comparison to the post-Lyme healthy group, higher frequencies of antibodies to p28 (P < 0.05), p30 (P < 0.05), p31 (P < 0.0001), and p34 (P < 0.05) proteins were found in the PLDS group. Assessment of antibody reactivity to recombinant OspA confirmed the presence of elevated levels in PLDS patients (P < 0.005). The described antiborrelia antibody profile in PLDS offers clues about the course of the antecedent infection in affected patients, which may be useful for understanding the pathogenic mechanism of the disease.
Avoiding Program Failures Through Safe Execution Perturbations

We present an online framework to capture and recover from program failures and prevent them from occurring in the future through safe execution perturbations. The perturbations are safe as they respect the semantics of the program. We use a checkpointing/logging mechanism to capture a program execution to an event log. If the execution results in a failure, the framework automatically searches for perturbation of the execution by altering the event log and replaying the execution using the altered log to avoid the failure. If found, the perturbation is recorded as a dynamic patch, which is later applied by all future executions of this application to prevent the failure from occurring again. Our experiments show that the proposed framework is very effective in avoiding concurrency faults, heap memory overflow faults, and malicious requests. The entailed overhead for normal execution is very low (2-18%).
Carbon Fraction Concentrations in a Haplic Luvisol as Affected by Tillage

Changes of soil organic matter (SOM) parameters were investigated in a haplic Luvisol with medium-heavy texture. Soil samples were taken from several layers at minimum (MT) and conventional (CT) tillage plots of a field experiment in Sitzenhof (Germany). All cultural practices except for tillage (crop rotation, fertilizing, protection measures, etc.) were identical over the whole time of the experiment. The concentrations of oxidizable carbon C ox and its constituents (humic acids (HA), fulvic acids (FA), and hot-water soluble carbon) are comparable in layers 15–20 cm in both variants. In 0–15 cm and 30–55 cm layers, these concentrations were higher in the MT variant. A similar trend was observed in the colour quotient values of humic substances Q4/6, which indicates increasing condensation of humus substances (HS) at deeper layers in both variants, and it is also confirmed by a humic to ful vic acids ratio HA:FA. Concentrations of SOM fractions were higher (except 15–20 cm layers) in the MT than CT treatment throughout the profile, especially below the 30 cm depth. The SOM did not accumulate markedly in the surface layer of long-term MT treatment.
Usefulness of C-Reactive Protein Plasma Levels to Predict Exercise Intolerance in Patients With Chronic Systolic Heart Failure.

Patients with heart failure (HF) have evidence of chronic systemic inflammation. Whether inflammation contributes to the exercise intolerance in patients with HF is, however, not well established. We hypothesized that the levels of C-reactive protein (CRP), an established inflammatory biomarker, predict impaired cardiopulmonary exercise performance, in patients with chronic systolic HF. We measured CRP using high-sensitivity particle-enhanced immunonephelometry in 16 patients with ischemic heart disease (previous myocardial infarction) and chronic systolic HF, defined as a left ventricular ejection fraction ≤50% and New York Heart Association class II-III symptoms. All subjects with CRP >2 mg/L, reflecting systemic inflammation, underwent cardiopulmonary exercise testing using a symptom-limited ramp protocol. CRP levels predicted shorter exercise times ( R = −0.65, p = 0.006), lower oxygen consumption (VO 2 ) at the anaerobic threshold ( R = −0.66, p = 0.005), and lower peak VO 2 ( R = −0.70, p = 0.002), reflecting worse cardiovascular performance. CRP levels also significantly correlated with an elevated ventilation/carbon dioxide production slope ( R = +0.64, p = 0.008), a reduced oxygen uptake efficiency slope ( R = −0.55, p = 0.026), and reduced end-tidal CO 2 level at rest and with exercise ( R = −0.759, p = 0.001 and R = −0.739, p = 0.001, respectively), reflecting impaired gas exchange. In conclusion, the intensity of systemic inflammation, measured as CRP plasma levels, is associated with cardiopulmonary exercise performance, in patients with ischemic heart disease and chronic systolic HF. These data provide the rationale for targeted anti-inflammatory treatments in HF.
The Effects of Unemployment and Underemployment on Employment Opportunities: Results from a Correspondence Audit of the Labor Market for College Graduates

The authors use data from a resume audit to estimate the impact of unemployment and underemployment on the employment prospects of recent college graduates. They find no statistical evidence linking unemployment spells of different durations to employment opportunities. By contrast, college graduates who are underemployed have callback rates that are 30% lower than those of applicants who are adequately employed. The null effects associated with unemployment and the adverse effects associated with underemployment are robust across cities with relatively tight and loose labor-market conditions. Internship experience obtained while completing one’s degree substantially reduces the negative effects of underemployment. The data support the proposition that employers view underemployment as a strong signal of lower expected productivity.
Tire-Road Friction Measurement on Highway Vehicles

This chapter focuses on real-time tire-road friction coefficient measurement systems that are aimed at estimating friction coefficient and detecting abrupt changes in its value. The main type of friction estimation systems presented here are systems that utilize longitudinal vehicle dynamics and longitudinal motion measurements. The algorithms and experimental results presented in this chapter are largely adapted from the paper published by Wang, et al. (2004).
Arctic Storm and Its Impact on the Surface Winds over the Chukchi-Beaufort Seas

Storms generating in the Chukchi-Beaufort Seas or traveling to the area play an important role impacting the regional climate and environment. Surface wind associated with storm exerts dynamic forcing, modifying sea ice movements and ocean currents, opening sea ice leads, and redistributing sea ice coverage. In this study, Arctic storms and their impacts on the surface wind field in the Chukchi-Beaufort Seas are studied with the newly developed Chukchi-Beaufort High-resolution Atmospheric Reanalysis (CBHAR) for the period of 1979–2009. Storm activities over the Chukchi-Beaufort Seas region show a seasonal variability. Storms are less but stronger in cold season, and more in number but weak in warm season. The storms impact the area’s surface wind field by enhancing the frequency of strong winds. When the storms interact with the semi-permanent weather system Beaufort High, extremely strong winds often occur.
Fulminating Gastroenterocolitis Caused By Staphylococci: Its Apparent Connection with Antibiotic Medication

Summary Detailed anatomic reports are presented of 8 cases in which various major surgical operations were performed, accompanied by administration of several broad spectrum antibiotics, including terramycin, Syncrobin (penicillin and streptomycin), and aureomycin. Dosages, which were in general comparatively small, and the combinations of the antibiotics used in some individual cases are presented in Table I. The clinical picture was characterized by nausea, vomiting, and a few loose stools, commencing from the first to the fourth postoperative day and changing rapidly into massive diarrheas, leading to a severe shock-like state. Death occurred from the third to the eleventh postoperative day. The causative agent responsible for the acute inflammation of the gastrointestinal tract was presented by large masses of staphylococci within the desquamated or loosely adherent pseudomembranous exudate covering the mucous coat, particularly in the small intestine (see Fig. 2 to 4). The recent inflammatory reaction was in general restricted to mucosa and submucosa. In five cases, colonies of coagulase positive hemolytic staphylococci were recovered from the intestinal tract and/or from the lungs. The clinical course and pathologic-anatomic findings, based in particular on bacteria stains of the tissue sections from the gastrointestinal tract and including the recent degenerative changes in the adrenals and kidneys, point to a severely toxic state from massive staphylococcic infection of the gastrointestinal tract, but not to a septicemic process. The staphylococci grown on blood agar in the few instances tested were resistant against all the antibiotics used in these cases. In three recent observations, not reported in detail, the same clinicopathologic syndrome was present, with the same rapid fatal outcome and the same pathologic, histologic, bacterioscopic and cultural findings. The staphylococci grown from the intestinal tract and from the lungs in these cases were sensitive only to Erythromycin, but not to the antibiotics administered.
Sugar Cane Refining And Processing Company: A Comprehensive Case In Measuring A Firms Cost Of Capital

The Sugar Cane Refining and Processing Company is a comprehensive case illustrating how a firms financial manager should calculate the firms cost of capital. Senior level undergraduate and graduate corporate financial management courses cover advanced topics in cost of capital and applying the rate in capital budgeting. To cover this relevant topic in a single case, the invented or armchair approach is used. This case is completely contrived but is very educationally effective.
Transbodied Spaces: The Home Experiences of Undocumented Mexicans in Minnesota

Much of the scholarship around the notion of home draws on ethnographic and phenomenological studies. As a result, the emphasis is on presence, the physical and material existence of people, spaces...
INTELLECTUAL OPPORTUNITY STRUCTURES AND SCIENCE- TARGETED ACTIVISM: INFLUENCE OF THE EX-GAY MOVEMENT ON THE SCIENCE OF SEXUAL ORIENTATION *

Social movements frequently seek to shape knowledge-producing institutions, including those found within the sciences. This essay takes up and refines the concept of intellectual opportunity structure to describe factors that enable or constrain movement efficacy in these efforts. Based on interviews with key claimants, participant observation at conferences, and content analysis of media, scientific, and activist literature, this article explains how the ex-gay movement in the United States mobilized knowledge and protest to shape mainstream science. Since 1973, gay-affirmative policies in mainstream mental health institutions have increasingly blocked construction of scientific facts based on the pathologization of homosexuality. Yet, the ex-gay movement has more recently found limited success blending theological premises and science-based methodologies. Shifts in intellectual opportunities, including formal acknowledgement of religious diversity by psychologists, have led the American Psychological Association (APA) to incorporate some ex-gay movement ideas even as the APA maintains that sexual orientation, newly defined, cannot be therapeutically altered. In August of 2009, the American Psychological Association (APA) issued a widely publicized report and position statement on therapies and religious ministries intended to change a person’s sexual orientation from homosexual to heterosexual. This report included a compromise that was surprising, given the dominant anti-reorientation stance of professional mental health associations in the United States. After reviewing the scientific literature, the APA advised licensed mental health providers not to impose a priori sexual identity outcomes on clients interested in reorientation, but rather, such clients should guide a process of “sexual orientation identity exploration.” In effect, providers following this position may help some same-sex attracted clients pursue a heterosexual identity and lifestyle in alignment with their religious values in certain circumstances (Swartz 2011). By recognizing that conservative religious identity may be more meaningful to a client than same-sex attraction, the APA’s position incorporated some ideas promoted by the ex-gay movement. Yet, the APA did not accept ex-gay ideas wholesale by any means. Maintaining a gay-affirmative stance, the report newly defined “sexual orientation” independent of identity, as a physiological pattern of arousal and desire that cannot be therapeutically altered. The APA adamantly maintains that homosexuality is not a mental illness, sexual orientation change attempts are not likely to succeed, and such attempts can be harmful. Furthermore, clients engaged in “sexual orientation identity exploration” should be fully informed of these scientific facts, and neither the therapist nor the client should be motivated by anti-gay stereotypes (APA Task Force 2009: 63-4).
Artificial Seed System for Bioassay of Cowpea Weevil (Coleoptera: Bruchidae) Growth and Development

An artificial seed system has been developed to evaluate putative allelochemicals and plant fractions for effects on growth and development of the bruchid, Callosobruchus maculatus (F.). The artificial seeds, which are prepared using flour from a bruchid-susceptible cowpea cultivar, permit rates of larva growth and development and survivorship comparable with those obtained with the intact parent cowpea seed. Experiments with artificial seeds containing various inhibitors of mammalian digestive proteinases demonstrated the applicability of the technique to evaluation of chemicals for effects on bruchid growth and development. Certain inhibitors (e.g., Bowman—Birk inhibitor from soybeans) have adverse effects on bruchid growth and development; others (e.g., lima bean trypsin inhibitor) have little or no effect.
Thermal "fingerprinting" of cells using FTIR

Every cell is composed of a combination of proteins and lipids that define the cell. The biomolecular composition of a cell can yield a unique IR spectral profile, termed chemical “fingerprint”, in the FTIR. Even though it provides overall information on the state and composition, the challenge is in obtaining a more sensitive and mechanistically relevant “fingerprint” of a cell particularly in the protein regime where numerous detection assays are now based [1]. Heat induced denaturation of proteins in a cell, which can be termed as thermal “fingerprint”, offers detailed and mechanistically relevant information for identification and characterization of different cells. For this study, the chemical and the thermal “fingerprint” of four different cell types are characterized and compared — human dermal fibroblasts (HDFs), LNCaP prostate tumor cells, smooth muscle cells (SMCs) and microvascular endothelial cells (MVECs). Multiple protein denaturation peaks were observed during heating from room temperature to 90°C at 1°C/min that are cell specific. A correlation coefficient (r) was used to compare responses between the cell types (higher ‘r’ implies closer resemblance). For the chemical “fingerprint”, r values of cells compared to HDFs are 0.97 for MVECs, 0.91 for LNCaPs and 0.70 for SMCs. Similarly, for the thermal “fingerprint”, r values of cells compared to HDFs are 0.86 for MVECs, 0.73 for LNCaPs and 0.54 for SMCs. The deviation of ‘r’ values from 1.00 is wider in the case of the thermal “fingerprint” than the chemical “fingerprint”. This result demonstrates that thermal “fingerprinting”, based on protein denaturation, offers a mechanistic basis for enhanced differentiation between cells as compared to chemical “fingerprinting”. Extensive applications ranging from rapid disease diagnostics, forensics, cell culture quality control, cell sorting techniques etc. may benefit from this approach.Copyright © 2007 by ASME
The role of morbidity and mortality (M&M) conferences in medical education.

M&M conferences are an integral part of contemporary medical education and are often identified as a rich learning event in the instructional curriculum. While the conferences can have variable formats, they should adhere to some basic adult learning and patient safety principles if they are to be educational and change the standard of healthcare in a community. A just culture and a safe learning environment must be pervasive. Unexpected and adverse outcomes should be systematically identified, presented and discussed in a timely fashion. The case presentation should come from the providers most aware of both the details and the rationale for the medical decisions. Discussions should be free of finger pointing and accusations, be evidence-based, and have participation by individuals with expertise in the topic. The focus should not be on punishing errors, but rather on developing behaviors and systems that minimize the opportunity for misadventures and that recognizes mistakes will still occur and catches those errors before patients are harmed.
A statistical study of absolute eosinophil cell counts in healthy young adults using logarithmic analysis

Abstract Eosinophil cell counts were made at 8:00 a.m. on free-flowing venous blood from forty-two fasting healthy young males during a two-week period. Six counts were made on each individual. The data from two hundred fifty-two counts were treated statistically using log-probit analysis and Litchfield's technique. From the statistically treated data the following calculations and observations were made: (a) The individual counts ranged from 45 to 483 cells per cubic millimeter. (b) The logarithmic mean eosinophil count was 179 cells per cubic millimeter. (c) The fiducial limits of the logarithmic mean (median) were 159 and 204 cells per cubic millimeter. (d) The range of two standard deviations extended from 72 to 440 cells per cubic millimeter. (e) The mean eosinophil count (arithmetical) was 207 cells per cubic millimeter. (f) The standard error of the arithmetical mean was 15.9.
Nutritive value of food served calculated from food purchased in 14 nursing homes.

Adjustments are needed in both quantities and types of food served in the nursing homes surveyed in this study to meet recommended nutrient levels as indicated by the Model Food Plan.
Emergency Preparedness Policy and Practice in Massachusetts Hospitals A Case Study

Hospital emergency preparedness has evolved in response to and been challenged by threats of terrorism, meteorological disasters, and public health emergencies. In this case study, the authors examined emergency preparedness policy and practice in Massachusetts hospitals following 9/11/2001, identifying areas of success and opportunities for improvement. Using a qualitative descriptive approach, data analysis included the examination of documents and public health policy. Snowball technique was used to recruit nurses, public health policy makers, and other first responder leaders with historical and present knowledge of emergency preparedness policy and practice. Content analysis identified emerging themes and lessons learned. Key findings included the importance of standardized training, the value of interprofessional collaboration and communication across organizations, and the impact of decreased funding and prior incidents. The lessons learned from this case study contribute to the evolving body of knowledge about emergency preparedness for all hospitals and public health facilities, and their community health partners. Emergency preparedness is a dynamic process, and as it continues to evolve, additional research will be needed to standardize training, encourage collaboration, and facilitate communication so that incident response by hospital professionals, including occupational health nurses, and their public health and community partners is more effective.
Mammalian Reproductive Physiology

Not many years ago, environments were regarded as being relatively stable and species were presumed to have evolved life histories in equilibrium with such environments. More recently, however, attention has been drawn to the fluctuating and uncertain nature of most environments and the necessity of organisms to adapt to this heterogeneity or perish (Levins, 1968). Biologists have begun seriously to consider life history strategies as phenotypic traits that are responding to sets of environmental variables. Today there is increasing awareness of the great complexity of selective forces acting on the evolution of life histories at both the genetic and phenotypic levels (Boyce, 1984; Emlen, 1984).
Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): Antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer

Aggregated amyloid-β peptide 1–42 (Aβ42), derived from the cellular amyloid precursor protein, is one of the pathological hallmarks of Alzheimer’s disease (AD). Although active immunization against Aβ42 peptide was successful in AD mouse models and led to removal of plaques and improved memory, a similar clinical trial in humans (Aβ42 peptide immunization with QS-21 adjuvant) was stopped in phase II, when 6% of the treated patients developed encephalitis. Currently ongoing passive immunizations with the injection of preformed monoclonal antibodies against different epitopes within the Aβ1–42 peptide, which do not lead to activation of the immune system, have shown some effects in slowing AD pathology. Active DNA Aβ42 immunizations administered with the gene gun into the skin are noninflammatory because they activate a different T-cell population (Th2) with different cytokine responses eliciting a different humoral immune response. We present our findings in rhesus macaques that underwent the DNA Aβ42 immunization via gene gun delivery into the skin. Six rhesus monkeys received two different doses of a DNA Aβ42 trimer vaccine. The humoral immune response was analyzed from blood throughout the study, and cellular immune responses were determined in peripheral blood mononuclear cells (PBMCs) after three and six immunizations. DNA Aβ42 trimer immunization led to high titer antibody responses in the nonhuman primate (NHP) model. Antibodies generated in the rhesus monkeys following DNA Aβ42 immunization detected amyloid plaques consisting of human Aβ42 peptide in the brain of the triple-transgenic AD mouse model. T-cell responses showed no interferon (IFN)-γ- and interleukin (IL)-17-producing cells from PBMCs in Enzyme-Linked ImmunoSpot assays after three immunization time points. At six immunization time points, IFN-γ- and IL-17-producing cells were found in immunized animals as well as in control animals and were thus considered nonspecific and not due to the immunization regimen. IFN-γ and IL-17 secretion in response to Aβ42 peptide restimulation became undetectable after a 3-month rest period. Intradermal DNA Aβ42 immunization delivered with the gene gun produces a high antibody response in NHPs and is highly likely to be effective and safe in a clinical AD prevention trial in patients.
Acidic Precipitation Research in Italy

A concise scenario of the emissions and the main environmental problems in Italy are discussed together with the measures programmed by the National Energy Plan. The aims and characteristics of the main monitoring networks, past and present, are illustrated.
Comparison of hardware and software implementations of selected lightweight block ciphers

Lightweight block ciphers are an important topic of research in the context of the Internet of Things (IoT). Current cryptographic contests and standardization efforts seek to benchmark lightweight ciphers in both hardware and software. Although there have been several benchmarking studies of both hardware and software implementations of lightweight ciphers, direct comparison of hardware and software implementations is difficult due to differences in metrics, measures of effectiveness, and implementation platforms. In this research, we facilitate this comparison by use of a custom lightweight reconfigurable processor. We implement six ciphers, AES, SIMON, SPECK, PRESENT, LED and TWINE, in hardware using register transfer level (RTL) design, and in software using the custom reconfigurable processor. Both hardware and software implementations are instantiated in identical Xilinx Kintex-7 FPGAs, which enables direct comparison of throughput, area, throughput-to-area (TP/A) ratio, power, and energy. Results show that TWINE and AES have the highest TP/A ratios for hardware and software implementations, respectively, assuming an area target of 300–450 LUTs. In terms of direct comparison, software implementations on tailored reconfigurable processers generally use less power — especially where reconfigurable instruction set extensions are permitted. However, custom hardware implementations have higher throughput and energy-efficiency than software implementations on the same platform.
Examining Africentric Cultural Values, Ethnic Identity, and Substance Use Abstinence in Low-Income, Early Adolescent, African American Girls:

An examination of cultural protective factors that foster substance use abstinence among low-income, early adolescent, African American girls may be helpful in understanding how to promote resilience and reduce negative health outcomes. This study examined the relations between Africentric cultural values, ethnic identity, and substance use abstinence among 196 low-income African American early adolescent girls (age 11-14 years). Results of logistic regressions revealed that Africentric values were negatively linked to cigarette and alcohol abstinence. Results also showed a significant positive interaction between Africentric cultural values and ethnic identity exploration that contributed to increased cigarette and alcohol abstinence. Implications for research and practice with African American early adolescent girls are discussed.
Is the closet a closet? Decolonizing the coming out process with Latin@ adolescents and families

ABSTRACTThe coming out process is complex and diverse. Some believe being out is optimal for health, while others suggest that disclosing one’s sexual orientation invites rejection, isolation, and many other dangers. Moreover, this process has been critiqued for being constructed through the experiences of white middle-class gay men. Given these critiques, clinicians must be wary of positioning coming out as a goal of therapy when working with queer adolescents, especially for adolescents of color. This article aims to offer family therapists trans-theoretically informed points of considerations when working with this population as well as to decolonize the coming out process.
Producing Accessible Video-Based Training on Assistive Technology:

In this article we describe the development of a set of video-based training materials designed to present information on the availability and use of assistive technology (AT). The purpose of the article is two-fold: (a) to briefly describe the instructional materials, and (b) to describe the processes used to make the materials accessible to persons with disabilities. Describing the instructional materials provides information for potential users of the materials, and describing the development process provides information for instructional designers about the decisions made and processes used to make the materials accessible.The materials were designed for use in group training or stand alone training, and for in-service or pre-service2 audiences. Designing accessible training materials in a variety of instructional formats presented a challenge. The materials had to be sufficiently self-explanatory for stand-alone use while providing presentation materials for group-based instruction, in a format that ...
Knowledge base management for experiment planning in molecular genetics

The use of a representation language involving schemata and associated derived models has been extended to include all aspects of domain knowledge and strategy and heuristic problem solving knowledge. This uniform representation will allow the extension of knowledge base management techniques for acquisition and retrieval of procedural knowledge.
Ventricular function in idiopathic hypertrophic subaortic stenosis. A ballistocardiographic and angiographic correlative study.

Abstract Patients with idiopathic hypertrophic subaortic stenosis were studied by ballistocardiographic and angiographic techniques. A number of statistically significant differences were found between those with hypertrophic subaortic stenosis and normal subjects of similar age range. This ballistocardiographic study confirms findings of previous studies showing a greater early systolic contractile force in these patients with hypertrophic subaortic stenosis and more rapid acceleration of emptying. Correlation studies indicate that certain ballistocardiographic variables may quantitatively reflect ventricular function. Therefore, we have shown that relating ballistocardiographic measurements to dynamic variables may be useful in considering ventricular abnormality. It is strongly suggested that the relation of the ballistocardiogram to ventricular function is the major value inherent in the wave forms. Previous rejection of the ballistocardiogram as a useful clinical device or as an investigative technique appears to have been premature.
Abstract 283: Parkin Fails to Rescue Age-Dependent Cardiomyopathy in Mitochondrial DNA Mutator Mice

Temporal decline in mitochondrial function is widely considered to be a driver of cardiomyocyte aging, which in turn contributes to the prevalence of cardiovascular disease in the aging population....
The ‘Wheat Puzzle’ and Kartvelians route to the Caucasus

Wheat (Triticum L.) originated in the Fertile Crescent approximately 10 kya BP and has since spread worldwide. The ‘Wheat Puzzle’ was termed the observation that wild predecessors of five Georgian endemic wheat subspecies are found in Fertile crescent quite far from the South Caucasus. Kartvelian peoples are the ethno-linguistic group of speakers of Kartvelian languages (Georgian, Megrel, Laz, Svan). Kartvelian language is one of the seven language families of Eurasiatic superfamily, that may have arisen from a common ancestor over 15 kya BP (Pagel et al. in Proc Natl Acad Sci USA 110:8471–8476, 2013). One of the possibility to explain ‘Wheat Puzzle’ is that speakers of Protokartvelian language could be separated from Protoeurasiatic language speakers after migration from Africa to the Arabian peninsula and later moved to the northern part of Mesopotamia where wheat was domesticated. Kartvelian speakers could migrate further to South Caucasus together with domesticated wheat subspecies.
Colorectal Lymphoma: A Contemporary Case Series.

BACKGROUND Colon and rectal lymphomas are rare and can occur in the context of posttransplant lymphoproliferative disorder. Evidence-based management guidelines are lacking. OBJECTIVE The purpose of this study was to characterize the presentation, diagnosis, and management of colorectal lymphoma and to identify differences within the transplant population. DESIGN This was a retrospective review of patients evaluated for colorectal lymphoma between 2000 and 2017. Patients were identified through clinical note queries. SETTINGS Four hospitals within a single health system were included. PATIENTS Fifty-two patients (64% men; mean age = 64 y; range, 26-91 y) were identified. No patient had <3 months of follow-up. Eight patients (15%) had posttransplant lymphoproliferative disorder. MAIN OUTCOME MEASURES Overall survival, recurrence, and complications in treatment pathway were measured. RESULTS Most common presentations were rectal bleeding (27%), abdominal pain (23%), and diarrhea (23%). The most common location was the cecum (62%). Most frequent histologies were diffuse large B-cell lymphoma (48%) and mantle cell lymphoma (25%). Posttransplant lymphoproliferative disorder occurred in the cecum (n = 4) and rectum (n = 4). Twenty patients (38%) were managed with chemotherapy; 25 patients (48%) underwent primary resection. Mass lesions had a higher risk of urgent surgical resection (35% vs 8%; p = 0.017). Three patients (15%) treated with chemotherapy presented with perforation requiring emergency surgery. Overall survival was 77 months (range, 25-180 mo). Patients with cecal involvement had longer overall survival (96 vs 26 mo; p = 0.038); immunosuppressed patients had shorter survival (16 vs 96 mo; p = 0.006). Survival in patients treated with surgical management versus chemotherapy was similar (67 vs 105 mo; p = 0.62). LIMITATIONS This was a retrospective chart review, with data limited by the contents of the medical chart. This was a small sample size. CONCLUSIONS Colorectal lymphoma is rare, with variable treatment approaches. Patients with noncecal involvement and chronic immunosuppression had worse overall survival. Patients with mass lesions, particularly cecal masses, are at higher risk to require urgent intervention, and primary resection should be considered. See Video Abstract at http://links.lww.com/DCR/A929.
Behavioral Economics and Framing Effects in Guilty Pleas: A Defendant Decision Making Experiment

With over 90% of convictions resulting from guilty pleas, it is of great importance to examine factors influencing the likelihood of plea acceptance. Prior research suggests individuals are risk-se...
Abstract P122: Downregulation and Inhibition of PKCα Causes Increased Ca 2+ -Sensing Receptor-Mediated Vascular Relaxation in Aged Dahl Salt-Sensitive Rats

The G protein-coupled Ca2+-Sensing Receptor (CaSR) mediates extracellular calcium (Ca2+e) - induced relaxation of mesenteric arteries under tension and may therefore play a role in blood pressure r...
Toward Culturally Sustaining Governance in Higher Education: Best Practices of Theory, Research, and Practice

Demographic shifts within the nation have elicited an explicit and implicit call to action to address issues of diversity, equity, and inclusion. Topics such as curriculum, access, and tuition and ...
Impact of dipyridamole on adenosine dosing in pediatric and young adult patients after heart transplantation

Background Relative contraindications to adenosine use have included heart transplant and dipyridamole. We previously demonstrated the safety and efficacy of adenosine-induced atrioventricular (AV) block in healthy young heart transplant recipients while suspending dipyridamole therapy (dual antiplatelet agent). This prospective follow-up study evaluated the safety and efficacy of adenosine use in the same cohort of heart transplant recipients while on dipyridamole. Methods Adenosine was incrementally dosed until AV block occurred (maximum 200 mcg/kg up to 12 mg). The primary outcome was clinically significant asystole (≥12 seconds). Secondary outcomes included maximal adenosine dose, AV block duration, dysrhythmias, and clinical symptoms. Outcomes were compared to the parent study. Results Thirty of 39 eligible patients (5-24 years) were tested. No patient (0%, CI 0%-8%) experienced clinically significant asystole. AV block occurred in 29/30 patients (97%, CI 86%-100%). The median dose causing AV block was 50mcg/kg (vs 100 mcg/kg off dipyridamole; P = .011). Seventeen patients (57%, CI 39%-72%) required less adenosine to achieve AV block on dipyridamole; six (20%) required more. AV block occurred at doses ≥25 mcg/kg in all patients. In pairwise comparison to prior testing off dipyridamole, no significant change occurred in AV block duration, frequency of cardiac ectopy, or incidence of reported symptoms. No atrial fibrillation/flutter occurred. Conclusions AV block often occurs at twofold lower adenosine doses in healthy young heart transplant recipients taking oral dipyridamole, compared with previous testing of this cohort off dipyridamole. Results suggest that initial dosing of 25 mcg/kg (maximum 0.8 mg) with stepwise escalation poses low risk of prolonged asystole on dipyridamole.
Lifestyle balance, restful and strenuous occupations, and physiological activation

A balance between stressful and restful occupations is an important component of lifestyle balance (LB). We argue that excessive physiological activation from the stress of everyday engagement in o...
Sodium bicarbonate transporter NBCe1 regulates proliferation and viability of human prostate cancer cells LNCaP and PC3.

Studies on cultured cancer cells or cell lines have revealed multiple acid extrusion mechanisms and their involvement in cancer cell growth and progression. In the present study, the role of the sodium bicarbonate transporters (NBCs) in prostate cancer cell proliferation and viability was examined. qPCR revealed heterogeneous expression of five NBC isoforms in human prostate cancer cell lines LNCaP, PC3, 22RV1, C4-2, DU145, and the prostate cell line RWPE-1. In fluorescence pH measurement of LNCaP cells, which predominantly express NBCe1, Na+ and HCO3--mediated acid extrusion was identified by bath ion replacement and sensitivity to the NBC inhibitor S0859. NBCe1 knockdown using siRNA oligonucleotides decreased the number of viable cells, and pharmacological inhibition with S0859 (50 µM) resulted in a similar decrease. NBCe1 knockdown and inhibition also increased cell death, but this effect was small and slow. In PC3 cells, which express all NBC isoforms, NBCe1 knockdown decreased viable cell number and increased cell death. The effects of NBCe1 knockdown were comparable to those by S0859, indicating that NBCe1 among NBCs primarily contributes to PC3 cell proliferation and viability. S0859 inhibition also decreased the formation of cell spheres in 3D cultures. Immunohistochemistry of human prostate cancer tissue microarrays revealed NBCe1 localization to the glandular epithelial cells in prostate tissue and robust expression in acinar and duct adenocarcinoma. In conclusion, our study demonstrates that NBCe1 regulates acid extrusion in prostate cancer cells and inhibiting or abolishing this transporter decreases cancer cell proliferation.
Evaluation of Models and Measurements to Estimate Solar Radiation for 1-Axis Tracking Modules at NREL’s SRRL

Solar radiation reaching photovoltaic (PV) modules on a 1-axis tracking system can be measured by reference cells or thermopiles. The former is often biased due to the reflection of solar radiation by the glass cover of the PV. The uncertainty can be moderated by applying a correction factor, as a function of solar incident angle and the refractive index of the glass, to the measurement. On the other hand, solar radiation on the inclined PV panels can be computed by transposition models using global horizontal irradiance (GHI) observations from thermopiles. This study examines the models and measurements to estimate solar radiation for 1-axis tracking modules at the National Renewable Energy Laboratory’s (NREL’s) Solar Radiation Research Laboratory (SRRL). The 1-minute plane-of-array (POA) irradiances from 2019 are computed using the observed GHIs and a transposition model developed by Perez et al. The POA irradiances are compared with the observation by an IMT reference cell and a Kipp & Zonen CM Pyranometer 22 (CMP22) thermopile. For the SRRL’s 1-axis tracking system with an annual solar energy of 2323.9 kWh/m2, the POA irradiance is overestimated by ~70 kWh/m2 using the transposition model. This bias is reduced by more than 50% using the IMT measurements calibrated by a correction factor for a PV surface of antireflection coated glass.
Centroid Approximation for Bootstrap.

Bootstrap is a principled and powerful frequentist statistical tool for uncertainty quantification. Unfortunately, standard bootstrap methods are computationally intensive due to the need of drawing a large i.i.d. bootstrap sample to approximate the ideal bootstrap distribution; this largely hinders their application in large-scale machine learning, especially deep learning problems. In this work, we propose an efficient method to explicitly \emph{optimize} a small set of high quality "centroid" points to better approximate the ideal bootstrap distribution. We achieve this by minimizing a simple objective function that is asymptotically equivalent to the Wasserstein distance to the ideal bootstrap distribution. This allows us to provide an accurate estimation of uncertainty with a small number of bootstrap centroids, outperforming the naive i.i.d. sampling approach. Empirically, we show that our method can boost the performance of bootstrap in a variety of applications.
Using ego-network analyses to examine journal citations: a comparative study of public administration, political science, and business management

This study demonstrates how social network analysis, specifically ego-network analysis, can be used as a methodology to investigate the degrees of the isolation, insularity, and prestige of academic journals in a particular field in relation to other fields. Using the example of journals in public administration for illustrative purposes, we analyze the network of connections between journals in this field and the ones in two related fields: political science and business/management. Earlier studies found that the research in public administration was largely isolated from the three disciplines that were its foundations: law, management, and political science. Using ego-network analyses and ratio calculations from the Web of Science citation data, we found that the top journals of public administration were indeed relatively isolated in the years 2005, 2010, and 2015. Of the public administration journals, Public Administration Review (PAR) and the Journal of Public Administration Research and Theory (JPART) were increasingly more recognized (less isolated and became more prestigious) among the journals in other fields. This methodology can be applied to the journals in other fields to study the relations between fields, particularly the relative academic prestige of the fields, in terms of journal citations.
Prediction of Forced Response Using Expansion of Perturbed Reduced Order Models with Inexact Representation of System Modes

Variability in measured data is a common problem in the engineering practice. Changes in the mass and stiffness of the same structural component can occur due to minor variability in the tolerances used during the production/manufacturing process. Differences can exist between the real physical structure and its mathematical model representation (FEM) as well as the predicted response and the actual dynamic behavior of the system. For models in which limited data exists or is collected, the quality of the equivalent reduced order model is dependent on the retained modal parameters as well as the level of correlation of the mode shapes. Prediction of system level forced response from the expansion of these reduced order models can be affected by the use of inexact representations of the system modes such as those from Guyan reduced models. Furthermore, the reduction methodology used, the degrees of freedom selected, as well as the number of retained modes can play an important role in the accuracy of the predicted dynamics of the system.
Thermodynamics of Superflow in the Helium Film

The saturated superfluid film is capable of acting as a siphon, allowing the superfluid to drain out of any containing vessel to find the lowest available gravitational level. As in any siphon, the pressure in the film is lower when it is flowing than when it is at rest, owing to the Bernoulli effect. Since the film has a free surface which presumably cannot support a pressure discontinuity, it was expected that the flowing film would collapse on itself, like a siphon with flimsy walls. In particular, at typical film flow velocities a reduction in thickness of about one-quarter was expected.1