cssi/SciSciGPT-SciSciNet huggingface dataset:
A Market Model of Eastern Bering Sea Alaska Pollock: Sensitivity to Fluctuations in Catch and Some Consequences of the American Fisheries Act

AbstractA simultaneous-equation equilibrium model of domestic and international markets for fillets, surimi, and roe of Alaska pollock (i.e., Walleye Pollock Gadus chalcogrammus) is used to examine the combined effect of variability in landings and changes in product mix on first wholesale prices and revenues. From the commencement of Americanization in the mid-1970s through the joint venture era of the 1980s and following full Americanization in early 1990s, U.S. producers of Alaska pollock focused mainly on selling surimi and roe to Japan. Passage of the American Fisheries Act of 1998 (AFA) unleashed an economic transformation that more than doubled fishery revenues without increasing exploitation rates or catches. The increased value came about because freedom from the race for fish allowed fishers and processors to increase product quality, improve product recovery rates, diversify their mix of product forms, and develop new markets in the USA and Europe. Despite the size and importance of the Alaska ...
Optimal incentive-compatible priority pricing for the M/M/1 queue

Consider a system that is modeled as an M/M/1 queueing system with multiple user classes. Each class is characterized by its delay cost per unit of time, its expected service time and its demand function. This paper derives a pricing mechanism which is optimal and incentive-compatible in the sense that the arrival rates and execution priorities jointly maximize the expected net value of the system while being determined, on a decentralized basis, by individual users. A closed-form expression for the resulting price structure is presented and studied.
A Left Hemiblock Improves Cardiac Resynchronization Therapy Outcomes in Patients With a Right Bundle Branch Block

Background: The current recommendation for cardiac resynchronization therapy (CRT) in congestive heart failure (CHF) patients is based on QRS duration, not on QRS morphology. It is not known whether patients with right bundle branch block (RBBB) respond to CRT. Hypothesis: This study was performed to compare the effects of CRT in CHF patients with pure RBBB vs those with a coexisting left hemiblock (LHB). Methods and Patient Population: A total of 271 consecutive patients who underwent CRT at Montefiore Medical Center were analyzed. Baseline ECGs were analyzed by 2 reviewers for RBBB and further classified into those with a coexisting LHB. Response to CRT was defined to be, at ≥6 months after CRT, either an improvement in ejection fraction (EF) of at least 5 %, or an improvement in New York Heart Association (NYHA) CHF class. A total of 44 patients were identified: 1 8 had pure RBBB and 2 6 had a coexisting LHB. The 2 groups were similar in respect to baseline characteristics (P > 0.05). Results: Only 4 out of 1 8 patients with pure RBBB compared to 1 8 out of 2 6 with LHB (P = 0.005) had an improvement in EF ≥5%. The mean EF was ―1% in the pure RBBB group, but +5.4% in those with LHB (P = 0 . 0031 ). Improvement in NYHA class was seen in o out of 1 8 with pure RBBB vs 7 out of 26 patients with LHB (P = 0.03). Conclusion: If patients with RBBB also had LHB, their response to CRT was significantly better than if they had RBBB alone.
Irradiance on a Flat Object Underwater

Relative irradiance as a function of the orientation of a flat object underwater has been calculated for clear-sunny and overcast lighting conditions from experimental radiance data. Tables give the relative irradiance on an object whose normal is oriented every 10° of tilt angle from the zenith and every 20° of azimuth. From theoretical considerations the computed irradiances should apply to other waters for which the ratio σ/α is the same as in the original experiment.
The distribution and morphology of parasympathetic preganglionic neurons in the cat sacral spinal cord as revealed by horseradish peroxidase applied to the sacral ventral roots.

Parasympathetic preganglionic neurons in the sacral parasympathetic nucleus (SPN) of the cat were studied by applying horseradish peroxidase (HRP) to the sacral ventral roots. The results were compared to data from earlier experiments in which these same neurons were labelled by HRP applied to the pelvic nerve at a point much further from the spinal cord. The present experiments have shown (1) The total number of neurons in the SPN determined by ventral root labelling is equal to the number obtained by pelvic nerve labelling. This indicates that virtually all SPN neurons send their axons into the pelvic nerve. (2) More extensive dendritic projections from SPN neurons were revealed than in the pelvic nerve experiments. In particular, a strong dendritic projection extended within the lateral marginal zone of the dorsal horn close to Lissauer's tract and horizontal dendrites projected well into the contralateral gray matter, some reaching the contralateral sacral parasympathetic nucleus. (3) The neurons labelled via any one ventral root were all contained within a region equal in length to one spinal segment but shifted rostrally by a small amount. Thus, no evidence was obtained for a long intraspinal pathway in which axons of spinal cord neurons entered ventral roots many segments away from their somata.
Discovery of the Hemochromatosis Gene Will Require Rethinking the Regulation of Iron Metabolism

The identity of the protein responsible for hemochromatosis, the iron overload disease, has eluded scientists for years. However, a recent report identifies the gene where the hemochromatosis defect lies. It is a gene that encodes a major histocompatibility complex (MHC) class-I-like protein called HLA-H. The mechanism by which an HLA-H defect alters iron metabolism is still unidentified. However, this new discovery will certainly ignite a new wave of study into the physiology of iron metabolism and its regulation.
Managing a socially constructed technology: the case of CT scanning

The effective management of technology must recognize that technology is embedded in social processes and that technology is shaped by both technical and social forces. The paper illustrates the study of technology through an examination of the interaction of these scientific, engineering, professional and social practices. Specifically we examine the case of computed tomography (CT) scanning, introduced in 1972 by EMI, an English firm. Despite EMI's early success, a handful of US, German and Japanese firms now dominate the global market. The question of whether EMI managed their entry into and exit from this business well has attracted considerable attention in the literature. We offer a new interpretation. >
Communication in a Poisson Field of Interferers

This paper presents a mathematical model for communication subject to both interference and noise. The spatial distribution of the interfering nodes is accounted for by resorting to a Poisson point process in the two-dimensional plane. We consider a realistic scenario of slowly-moving, asynchronous nodes in a wireless environment subject to both log-normal shadowing and fast Rayleigh fading. Under this scenario, we determine the statistical distribution of the cumulative interference at the output of a linear receiver, located anywhere in the two-dimensional plane. Furthermore, we provide the corresponding error performance analysis, which is valid for any linear modulation scheme. The proposed model captures all the essential physical parameters that impact network interference, but is simple enough to allow a tractable analysis and provide fundamental insights. Furthermore, our work generalizes the conventional analysis of linear detection in the presence of additive white gaussian noise (AWGN) and fast fading, allowing the traditional results to be extended in a simple way to include the effect of interference.
An epidemic of waterborne infectious hepatitis in France.

In an epidemic of infectious hepatitis in a French municipality, epidemiologic evidence pointed to an extensively contaminated municipal distribution system as the vehicle. The median incubation period of American personnel was 38 days with a range of 29 to 57 days. Prolonged exposure is not thought to have occurred and is therefore not considered to have influenced the length of the incubation period. Nor was there evidence that the length of the incubation period was influenced by the chlorination practiced. However, in-line chlorination is thought to have been a key factor in the remarkably low incidence of diagnosed hepatitis in an Army housing area receiving water from the municipal distribution system.
MODELING ARSENATE COMPETITIVE ADSORPTION ON KAOLINITE, MONTMORILLONITE AND ILLITE

The adsorption of arsenate (As(V)) on kaolinite, montmorillonite and illite was investigated at varying pH and competing anion concentration while holding As(V) concentration (6.7 X lo-' M), clay suspension density (2.5 g L-') and ionic strength (0.1 M NaCl) constant. The effects of 2 concen- trations of phosphate (P) or molybdate (MO) (6.7 X lo-' and 6.7 X 10m6 M) on As(V) adsorption envelopes (adsorption vs. pH) gave evidence for direct competitive adsorption (in the case of As(V) + P) and possibly site-specific non-competitive adsorption (As(V) + MO). Distinct As(V) adsorption maxima oc- curred at approximately pH 5.0 for kaolinite, 6.0 for montmorillonite and 6.5 for illite, and ranged from 0.15 to 0.22 mmol As(V) kg ~I. When both As(V) and P were present at equimolar concentrations (6.7 X lo-' M), As(V) adsorption decreased slightly, whereas As(V) adsorption substantially decreased in binary As(V)/P systems when the P concentration was 6.7 X 10mh M, which was 10 times greater than As(V). The presence of MO at equimolar (6.7 X 1O-7 M) and 10 times greater (6.7 X 10m6 M) concen- trations than As(V) caused only slight decreases in As(V) adsorption because the MO adsorption maximum occurred at pH < 4. The constant capacitance surface complexation model was applied to As(V) and P adsorption data and was used to predict As(V) adsorption at varying P concentrations. The model gave reasonable descriptions of As(V) adsorption on the 3 clay minerals at varyin g pH and in the presence of a competing oxyanion (P), indicating that surface complexation modeling may be useful in predicting As(V) adsorption in soils. Key Words-Arsenate competitive adsorption, Illite, Kaolinite, Montmorillonite.
Techniques for Structuring Database Records

Structuring database records by considering data item usage can yield substantial efficiencies in the operating cost of database systems. However, since the number of possible physical record structures for database of practical significance is enormous, and their evaluation is extremely complex, determining efficient record structures by full enumeration is generally infeasible. This paper discusses the techniques of mathematical clustering, iterative grouping refinement, mathematical programming, and hierarchic aggregation, which can be used to quickly determine efficient record structures for large, shared databases.
Non-invasive UPR monitoring system and its applications in CHO production cultures.

Unfolded protein response (UPR) is the primary signaling network activated in response to the accumulation of unfolded and/or misfolded protein in the endoplasmic reticulum (ER). The expression of high levels of recombinant proteins in mammalian cell cultures has been linked to the increased UPR. However, the dynamics of different UPR-mediated events and their impact on cell performance and recombinant protein secretion during production remain poorly defined. Here, we have created a non-invasive UPR-responsive, fluorescence-based reporter system to detect and quantify specific UPR-mediated transcriptional activation of different intracellular signaling pathways. We have generated stable antibody-expressing CHO clones containing this UPR responsive system and established FACS-based methods for real-time, continuous monitoring of the endogenous UPR activation in live cultures. The results showed that the UPR activation is dynamically regulated during production culture. The clones differed in their UPR patterns; both the timing and the degree of UPR-induced transcriptional activation were linked to cell performance, such as growth, and viability. In addition, the cell culture environment, such as media composition and osmolarity, significantly impacted endogenous UPR activation. Taken together, these data demonstrate a utility of this UPR monitoring system in recombinant protein production processes and the observations increase our understanding of the critical role of UPR in regulating diverse phenotypes of the cells including growth, survival and recombinant protein secretion under different culture environments and processing conditions. Biotechnol. Bioeng. 2013; 110: 2184–2194. © 2013 Wiley Periodicals, Inc.
Evidence against significant 19-nor-deoxycorticosterone production in patients with 17 alpha-hydroxylase deficiency.

Tetrahydro-19-nor-deoxycorticosterone (3α, 21-dihydroxy-19-nor-5β-pregnan-20-one, a presumed metabolite of 19-nor-DOC was sought in the conjugated steroid fractions of urine from patients with 17α-hydroxylase deficiency syndrome. The reference material was prepared by microbial reduction (Clostridium paraputrificum) of 19-nor-DOC. Urinary steroid fractions of appropriate polarity were examined by high resolution gas chromatography and gas chromatography/mass spectrometry (GC/MS) but no tetrahydro-19-nor-DOC was found. The high selectivity of the GC/MS technique ensured that the excretion of this compound could not exceed about 1% of the excretion of tetrahydroDOC. Assuming that tetrahydro-19-nor-DOC is a major metabolite of 19-nor-DOC, it can be stated that 19-nor-DOC production is not a significant feature of 17α-hydroxylase deficiency. This assumption may not be valid if 19-nor-DOC is formed from DOC in the kidney and is excreted unmetabolized soon after synthesis.
Role of APOBEC3G/F-Mediated Hypermutation in the Control of Human Immunodeficiency Virus Type 1 in Elite Suppressors

While many studies show that the APOBEC3 family of cytidine deaminases can inhibit human immunodeficiency virus type 1 (HIV-1) replication, the clinical significance of this host defense mechanism is unclear. Elite suppressors are HIV-1-infected individuals who maintain viral loads below 50 copies/ml without antiretroviral therapy. To determine the role of APOBEC3G/F proteins in the control of viremia in these patients, we used a novel assay to measure the frequency of hypermutated proviral genomes. In most elite suppressors, the frequency was not significantly different than that observed in patients on highly active antiretroviral therapy. Thus, enhanced APOBEC3 activity alone cannot explain the ability of elite suppressors to control viremia.
Finite Element Study of Conformity of Flow Diverter With Intracranial Aneurysmal Vasculatures

Endovascular stents in the last decade have been extensively used in intracranial aneurysm (IA) management. Stenting procedure is normally performed with the placement of spring coils inside the aneurysm, where stent will serve as a mechanical scaffold to help anchor the packed coils. Although coiling holds relatively lower morbidity and mortality rate than traditional treatment, its applications to wide-necked IAs, IAs with large fusiform shapes, and thin-walled IAs are still problematic due to the difficulty of securing the coils in the first two scenarios and the vascular susceptibility to coil damage in the last situation. Recent flow diverter concept however offers a potential alternative to address these challenging cases with only stent (flow diverter) being implanted. A flow diverter stent usually has relatively high metal surface coverage rate (∼80%) so that it can significantly divert blood flow from going inside the aneurysm, causing the decreased flow in IA and subsequently the thrombogenic cascade in favor of occluding the lesion. Meanwhile, a new flow conduit across IA orifice is expected to form based on endothelial cell re-pavement on the inner surface of the stent. It is thus of academic and clinical importance to further examine the mechanisms involved with flow diverter to better understand the procedure and improve the treatment outcome. Since the straightening of vessel by stent and incomplete apposition between stent filaments and arterial wall could both induce complications, current study applies a developed finite element method (FEM) workflow to evaluate the conformity of a CoCr alloy flow diverter (Pipeline™ Embolization Device as PED by ev3, MN, USA) to patient specific IA geometries.© 2011 ASME
Early-time response of the spherical antenna

The early-time response of the spherical antenna is determined by a two-step process. First, the high-frequency representation is derived by the technique known as the Watson transformation. The high-frequency results are then Fourier transformed to obtain the time response. The time region where these results are valid is given and comparisons to previous analyses are made. Conclusions regarding the utility of this method to other antenna shapes and different time regions are discussed.
Uniform longitudinal beam profiles in the Fermilab Recycler using adaptive RF correction

The Fermilab recycler ring is a permanent magnet based 8 GeV anti-proton storage ring. A wideband RF system, driven with ARB's (ARBitrary waveform generators), allows the system to produce programmable barrier waveforms. Beam current profile distortion was observed, its origin verified both experimentally and theoretically, and an FPGA-based correction system was designed, tested and implemented to level the bunch profile.
Self-Presentation Bias and Continuing Motivation Among Adolescents

Abstract This study investigated the reported return-to-task rates of girls and boys for a target individual and for themselves on hard and easy tasks. The return-to-task measure consisted of scenarios in which a male or female character performed a task that the character considered to be either hard or easy. Data were collected from 632 students in Grades 7, 9, and 11 at a junior and a senior high school in a large southwestern suburban school district. The return rates to hard and easy tasks for the subject and for the scenario character were compared for indications of self-presentation bias. The data revealed that both girls and boys preferred easy tasks over hard tasks and that girls had significantly higher (p < .01) return-to-task rates than boys did. Evidence of seif-presentation bias is present in an interaction in which subjects reported a significantly higher (p < .0001) rate of return to difficult tasks for themselves than for the scenario character, and a significantly lower return rate to e...
Pathway analysis using random forests classification and regression

Motivation: Although numerous methods have been developed to better capture biological information from microarray data, commonly used single gene-based methods neglect interactions among genes and leave room for other novel approaches. For example, most classification and regression methods for microarray data are based on the whole set of genes and have not made use of pathway information. Pathway-based analysis in microarray studies may lead to more informative and relevant knowledge for biological researchers. Results: In this paper, we describe a pathway-based classification and regression method using Random Forests to analyze gene expression data. The proposed methods allow researchers to rank important pathways from externally available databases, discover important genes, find pathway-based outlying cases and make full use of a continuous outcome variable in the regression setting. We also compared Random Forests with other machine learning methods using several datasets and found that Random Forests classification error rates were either the lowest or the second-lowest. By combining pathway information and novel statistical methods, this procedure represents a promising computational strategy in dissecting pathways and can provide biological insight into the study of microarray data. Availability: Source code written in R is available from http://bioinformatics.med.yale.edu/pathway-analysis/rf.htm Contact: hongyu.zhao@yale.edu Supplementary Information: Supplementary Data are available at http://bioinformatics.med.yale.edu/pathway-analysis/rf.htm
Reduced Vessel Elasticity Alters Cardiovascular Structure and Function in Newborn Mice

Elastic blood vessels provide capacitance and pulse-wave dampening, which are critically important in a pulsatile circulatory system. By studying newborn mice with reduced ( Eln +/ − ) or no ( Eln − / − ) elastin, we determined the effects of altered vessel elasticity on cardiovascular development and function. Eln − / − mice die within 72 hours of birth but are viable throughout fetal development when dramatic cardiovascular structural and hemodynamic changes occur. Thus, newborn Eln − / − mice provide unique insight into how a closed circulatory system develops when the arteries cannot provide the elastic recoil required for normal heart function. Compared with wild type, the Eln − / − aorta has a smaller unloaded diameter and thicker wall because of smooth muscle cell overproliferation and has greatly reduced compliance. Arteries in Eln − / − mice are also tortuous with stenoses and dilations. Left ventricular pressure is 2-fold higher than wild type, and heart function is impaired. Newborn Eln +/ − mice, in contrast, have normal heart function despite left ventricular pressures 25% higher than wild type. The major vessels have smaller unloaded diameters and longer lengths. The Eln +/ − aorta has additional smooth muscle cell layers that appear in the adventitia at or just before birth. These results show that the major adaptive changes in cardiovascular hemodynamics and in vessel wall structure seen in the adult Eln +/ − mouse are defined in late fetal development. Together, these results show that reduced elastin in mice leads to adaptive remodeling, whereas the complete lack of elastin leads to pathological remodeling and death.
The MDIBL in the Early Twenty-First Century: A New Beginning

The first decade of the twenty-first century brought significant changes, and a more stable fiscal outlook, to the MDIBL. It became clear early in the decade that the time had come for real strategic planning, including resurrecting a year-round research program with the potential of having a year-round Director on site. The fund-raising campaign associated with the Centennial had raised significant dollars (and partially paid for the new Conference Center), but it was clear that continued fiscal health and plans for expansion of the research program and administration would require very substantial increases in extramural funding, at the individual, state, and federal levels. Initial success came, after heavy lobbying in Maine’s capital by MDIBL administrators, with a grant from the Maine State Technology Foundation for a DNA Sequencing Center at the Laboratory, followed by other significant state bond issues that generated nearly $5M for the MDIBL. In addition and thanks to a very strategic hire of a new Administrative Director, the Laboratory was able to secure multimillion dollar NIH grants (BRIN then INBRE) to coordinate research and teaching throughout the state and support significant expansion of the administration of the Laboratory and a year-round research program by the end of the decade. A new, three-story research building was built with significant donated funds and a bank loan, after the NIH was unable to provide funds. However, the American Recovery and Reimbursement Act of 2009 provided funds for a second building, which was constructed after 2010. Two new dormitories, Spruce and Birch Halls, were also built during this period, using grants from NSF and significant donations from two Investigator families. The successful fund-raising, state bond issues, and significant overhead return from the BRIN/INBRE grants provided funds for the hiring of a cadre of year-round Investigators, as well as the first year-round Director by the end of the decade.
The Application of Vibrational Spectroscopy to Clay Minerals and Layered Double Hydroxides

This wide-ranging, well produced and inexpensive volume belongs on the work shelf of every research group involved in the study of clays or layered double hydroxides. The list of authors is a roll-call of the most prominent workers in the field, and, while not offering a comprehensive survey, the diverse contributions provide snapshots of the variety of techniques currently being employed in this area, and how these may be brought to bear on a wide range of problems of interest to all workers in the area, not just spectroscopists. This reviewer has long held that the vibrational spectroscopy of layered materials is a rich source of detailed information, some of it unobtainable in any other way, and deserves a place second only to X-ray diffraction. This volume may help persuade more researchers that without at least routine collection of infrared spectra, the characterization of layered materials is seriously incomplete. And if this involves a walk over to the Chemistry Building, so much the better for all concerned. For most clay chemists, including this reviewer, vibrational spectroscopy is a means to an end, but it is an extremely powerful means. Through the operation of selection rules, the number of distinct observable modes gives information about local symmetry. Frequency (more precisely, frequency2 × effective mass) relates directly to the stiffness of a bond, and thus, indirectly, to its strength. From this, it immediately follows that in favorable cases the vibrational spectrum can give information about the number and nature of subtly different sites. Finally, in favorable cases the separation of frequencies can give information about how equivalent units within the material are interacting with each other, information that is extremely difficult to obtain in any other way. While these broad general themes are not, on the whole, spelt out explicitly, their …
Exploiting commutativity to reduce the cost of updates to shared data in cache-coherent systems

We present Coup, a technique to lower the cost of updates to shared data in cache-coherent systems. Coup exploits the insight that many update operations, such as additions and bitwise logical operations, are commutative : they produce the same final result regardless of the order they are performed in. Coup allows multiple private caches to simultaneously hold update-only permission to the same cache line. Caches with update-only permission can locally buffer and coalesce updates to the line, but cannot satisfy read requests. Upon a read request, Coup reduces the partial updates buffered in private caches to produce the final value. Coup integrates seamlessly into existing coherence protocols, requires inexpensive hardware, and does not affect the memory consistency model. We apply Coup to speed up single-word updates to shared data. On a simulated 128-core, 8-socket system, Coup accelerates state-of-the-art implementations of update-heavy algorithms by up to 2.4×.
Quantum correlation of telecom wavelength photon-pair through multiple scattering media

We investigate the effect of multiple scattering on the telecom wavelength photon-pair. Our findings show that quantum correlation of polarization-entangled photon-pair is better preserved than polarization-correlated photon-pair in multiple scattering processes.
Risk and Resilience Factors Associated With Formal and Informal Income Generation Among Homeless Young Adults in Three U.S. Cities

This study used the risk and resilience framework to examine predictors of formal and informal sources of income among homeless young adults. Formal sources of income generation consisted of full-t...
Determination of lead,cadmium,arsenic and total mercury in wheat flour by inductively coupled plasma mass spectrometry

Objective To develop a method for determining the contents of lead,cadmium,arsenic and total mercury in wheat flour by inductively coupled plasma mass spectrometry. Methods After wet digestion with nitric acid,the sample was determined directly by Agilent 7700s inductively coupled plasma mass spectrometry under helium collision mode,and the correction equation and mixed internal standard were used to correct matrix interference and signal drifting. Results The contents of lead,cadmium,arsenic and total mercury in wheat flour can be determined simultaneously by ICP-MS. The RSDs of the method were less than 4%,the recoveries were 95. 0% ~ 110%. The analysis results of standard material were in line with the requirements of certificate. The results of 396 wheat flour real samples were satisfactory and the concentrations of four metal elements in wheat flour in Guangdong province were within the range of safety. Conclusion The concentrations of lead,cadmium,arsenic and total mercury in wheat flour can be determined rapidly and precisely by ICP-MS. This method is simple and reliable. It can be applied to the determination of multiple elements in the same type of foods.
Do program directors and their chief residents view the role of chief resident similarly

Background The chief resident plays an important role in family practice residencies and is positioned at the nexus of the relationship between the faculty and the residents. It is unknown if program directors and their respective chief residents view this position and the role of training and faculty development similarly. Methods Parallel surveys were sent to all family practice residency program directors and their respective chief residents to explore their perceptions of the importance of the tasks and roles of the chief resident and the effects that perceived training, feedback, and support have on the chief resident's satisfaction. Results Fifty-one percent of chief residents and their program directors returned surveys that could be analyzed in parallel. Program directors placed relatively greater importance on the administrative role of chiefs. Mentioned most frequently as problems were balancing administrative duties with other tasks, dealing with personnel issues, and working with the lack of a clear job description. Chiefs who participated in formal training programs and who perceived better burnout prevention were more satisfied with their position. Conclusions A large number of chief residents perceived gaps in the preparation for their position, particularly with regard to administrative skills. These deficiencies are particularly ironic in light of program directors' perceptions that administrative duties are of the highest importance among the tasks assigned to chief residents. Faculty development strategies and a program of burnout prevention for chief residents should be incorporated into each residency.
From "nothing" to "something" to "everything": bisexuality and metaphors of the mind.

Psychoanalytic understanding of female sexuality has continued to evolve since Freud presented it as a central and abiding question in psychoanalytic theory. This paper is an attempt to demonstrate that much of what we have learned and added to our theory is based in part on the classical thinking which remains a foundation of psychoanalytic wisdom about human sexuality in general, male and female. And this foundation rests on the cornerstone of the human longing for completeness, for "everything"--a bisexual core. A clinical case, the basis of psychoanalytic data, demonstrates, primarily through the analysis of a dream, the neurotic derailments that follow upon a disavowal of the need for the little girl to identify with the metaphorical representation of male genitalia. The theoretical underpinnings of this perspective are presented as well as a correction of a common misreading of Freud's ideas about anatomical "bedrock."
Application of Near Infrared Reflectance Spectroscopy to Determination of Fat in Cheddar Cheese

Mise au point d'une methode de dosage et comparaison des resultats obtenus avec ceux donnes par la methode officielle selon Rose-Gottlieb
Sarcomatoid renal cell carcinoma: genomic insights from sequencing of matched sarcomatous and carcinomatous components.

The estimated new kidney cancer cases diagnosed each year in the United Sates and in the world are ~63,000 and ~300,000, respectively (1,2). Renal cell carcinoma (RCC) represents over 90% of kidney cancer and consists of a group of malignancies arising from the renal epithelium and exhibiting distinct histopathological features (3-6). The 2004 WHO classification listed 12 different subtypes of RCC (4). With a better understanding of the molecular pathogenesis of RCC, the 2013 International Society of Urological Pathology (ISUP) consensus conference added several new entities (6).
An investigation of financial expertise improvement among CFOs hired following restatements

Purpose – The purpose of this paper is to examine chief financial officer (CFO) qualification improvement associated with restatements and restatement characteristics (restatement materiality). The study is motivated by recent high-profile financial scandals and increasing instances of restatements which focus public attention on the role of CFOs in maintaining the integrity and quality of corporate financial reporting. Design/methodology/approach – The study employs data composed of 80 restating firms matched with 80 non-restating firms with hand-collected CFO turnover information in the periods of 2003-2010. The research questions are tested in the logistic regression models. Findings – The results provide some support that restating firms are more likely to hire new CFOs with greater accounting knowledge and overall CFO qualification (both accounting knowledge and CFO work experience) than non-restating firms. Furthermore, the authors also find that the number of restating years has a positive effect o...
Estimation by Ranking Parameters

SUMMARY It is shown that a linear ordering of the parameter space is a useful generalization of classical estimates, and that for a certain class of loss functions, Bayes decision procedures lead to very simple linear orderings.
The Epstein-Barr virus EBNA2 protein induces a subset of NOTCH target genes in thyroid cancer cell lines but fails to suppress proliferation

Background Epstein-Barr virus is associated with lymphoid and epithelial malignancies and has been reported to infect thyroid cells. The Epstein-Barr virus protein, EBNA2, regulates viral and cellular promoters by binding to RBP-jκ. Similarly, NOTCH1, a tumor suppressor protein in thyroid epithelial cells, competes with EBNA2 for binding to overlapping sites on RBP-jκ. EBNA2 activates a subset of NOTCH-responsive genes in lymphocytes and myocytes; however, the effect of EBNA2 expression on NOTCH targets in epithelial cells is unknown. Here we have explored whether EBNA2 activates NOTCH1 targets in thyroid cancer lines and examined its effect on cellular proliferation. Methods Two human thyroid cancer lines, follicular FTC-236 and anaplastic HTh7, were transfected with EBNA2, NOTCH1, or control vectors. Notch targets were measured using quantitative reverse transcriptase polymerase chain reaction. Cellular proliferation was measured by MTT analysis. Results EBNA2 activated only a subset of NOTCH1 targets. Expression of HES1 and HEY1 were increased 10-fold in FTC-236 and HTh7 cells, respectively, but the majority of NOTCH1 targets examined were not affected. In contrast to NOTCH1, EBNA2 did not suppress proliferation. Conclusion EBNA2 does not activate most Notch1-responsive genes or suppress proliferation in human thyroid cancer cells. Instead, EBNA2 may compete with NOTCH1 for limiting amounts of RBP-jκ in epithelial cells and inhibit certain aspects of NOTCH1 signaling.
The impacts of wind and solar on grid flexibility requirements in the Electric Reliability Council of Texas

Abstract The installation of wind and solar capacity in the electric grid can influence net load ramp rates and volatility, affecting grid stability and operating costs. In this study, the statistical analysis of load, wind, and solar data from the Electric Reliability Council of Texas (ERCOT) shows how wind and solar capacity impacts these grid flexibility requirements. Growing wind capacity shows only minor correlation with increasing flexibility requirements, and appears to correlate with decreasing flexibility requirements in some instances. Growing solar capacity might initially improve grid flexibility requirements, particularly volatility. However, beyond a certain penetration level (about 1.0 GW in this study), further solar capacity growth develops a direct correlation with increasing flexibility requirements if load patterns do not change. While adding 15.7 GW of wind power had insignificant effects, adding 14.5 GW of solar to the ERCOT grid increases maximum 1-h ramp rates by 135%, 3-h ramp rates by 30%, ramp factors by 140%, 1-h volatility by 100%, and 1-day volatility by 30%. The geographic location and orientation of solar arrays influences these flexibility requirements, with fixed, southeast-facing panels providing a significant reduction. These results can inform strategies for managing the grid flexibility requirements created by growing renewable capacity.
OS11.2 Risk-adjusted survival outcomes for and features of 1p/19q codeletion oligodendrogliomas

Abstract Background: Oligodendrogliomas (OGs) are diffuse gliomas defined by IDH mutation and 1p/19q codeletion, in which response to treatment and survival are dictated not by histology, but by molecular subtypes. Methods: The US NCDB was queried for OG patients newly-diagnosed from 2004–2014. Patient and tumor factors were compared by Chi2 or t test. Overall survival (OS) was assessed by Cox proportional hazards and Kaplan-Meier methods, stratified by histology, grade, and codeletion status, and risk adjusted for age, sex, race, Charlson’s comorbidity index, insurance, facility location, chemoradiotherapy, and tumor location, laterality, and size. Results: 14,948 patients with gliomas with OG histology remained after exclusion, 67% (n=10,075) were WHO gr2, 33% were WHO gr3 (i.e. anaplastic), and 36% displayed mixed oligoastrocytoma histology. Complete 1p/19q data were available in 20% (n=2,920). Compared to gr2 non-codeleted cases, codeleted OGs presented at an older median age of 43 yrs (IQR: 25–52; vs. 38 yrs, IQR: 25–51, p<0.0001). Notably, 67% were MGMT methylated (vs. 38%, p<0.001) and 75% arose in the frontal lobe (vs. 56%, p<0.001), and 12% in the temporal lobe (vs. 30%). For treatment, 41% of gr2 codeleted OGs received chemotherapy (vs. 36%, p<0.01), 28% received radiotherapy (vs. 41%, p<0.001), 86% underwent surgery, 55% of which were GTR. In risk-adjusted analysis of gr2 OGs, codeletion was associated with significantly improved OS (HR 0.44, 95%CI: 0.27–0.72, p=0.001), with 2-yr and 5-yr OS rates of 96% (95%CI; 94–97) and 87% (95%CI: 84–90), respectively; vs. 87% (95%CI: 84–90) and 70% (95%CI: 63–76) in non-codeleted OG. Mixed histology was not significant (HR 1.49, 95%CI; 0.92–2.44, p=0.11). Compared to gr3 non-codeleted cases, codeleted anaplastic OGs presented at a median age of 46 yrs (IQR: 37–56; vs. 43 yrs, IQR: 40–46, p=0.066). 75% were MGMT methylated (vs. 46%, p<0.001) and a majority arose in frontal lobes (78% vs. 62%, p<0.001); involving temporal lobes in 9% (vs. 23%). For treatment, 84% of gr3 codeleted OGs received chemotherapy, 70% received radiotherapy, and 96% underwent surgery, 52% of which were GTR. In risk-adjusted analysis of gr3 OGs, codeletion was associated with significantly improved OS (HR 0.36, 95%CI: 0.22–0.59, p<0.001), with 2-yr and 5-yr OS rates of 90% (95%CI; 87–93) and 72% (95%CI: 64–77), respectively; vs. non-codeleted OGs’ 73% (95%CI: 68–78) and 47% (95%CI: 37–56). Mixed histology portends a worse OS (HR 1.72, 95%CI; 1.08–2.74, p=0.02). Conclusion: Although previously referred to as OGs, grade 2 and 3 diffuse gliomas without 1p/19q codeletion are markedly different from molecularly-defined OGs; particularly demonstrating reduced rates of MGMT methylation and significantly worse OS. In cases where a high grade OG is suspected histologically but 1p/19q are not codeleted, careful evaluation and management for IDH-wildtype GBM should be considered.
Environmental Pollution and the Developing Lung.

In this review, we discuss the impact of environmental tobacco smoke and particulate and gaseous air pollutants derived from fossil fuel combustion on a particularly vulnerable population, infants, and children. Indoor and outdoor air pollutants exacerbate chronic respiratory diseases and lower resp
Application of Immersive Virtual Reality Systems in an Interdisciplinary Design Studio Course

The architectural, engineering, and construction (AEC) industry has been witnessing a recent growth of application of visualization and virtual reality technology for design reviews. As our future generations of designers and engineers enter the industry, they will have to possess the ability to leverage such technology. This study aimed at evaluating the experience of students from an interdisciplinary design studio course, in performing internal design reviews with two different types of display systems. The research aimed at understanding which systems the students found most valuable, immersive, and enjoyable when visualizing their models. The first system utilized was a semi-immersive three screen display system, while the second was a single screen large LCD television system. The participants included five groups, with students from different disciplines, such as architecture and architectural engineering. The groups were randomly split into two tracks and took part in an ABBA experimental procedure. The studentsO responses were collected through a survey, which was administered after they reviewed their design with each system. Based on the findings, the researchers were able to conclude that the utilized semi-immersive display system promoted the studentsO sense of immersion, spatial presence, and enjoyment, over their regular collaboration pod using an LCD screen.
Kinetics and Mechanism of Methanol Conversion over Anatase Titania Nanoshapes

The kinetics and mechanism of methanol dehydration, redox, and oxidative coupling were investigated at 300 °C under dilute oxygen concentration over anatase TiO2 nanoplates and truncated-bipyramidal nanocrystals in order to understand the surface structure effect of TiO2. The two TiO2 nanoshapes displayed both (001) and (101) facets, with a higher fraction of the (001) facet exposed on the nanoplates, while truncated-bipyramidal nanocrystals were dominated by the (101) facet. A kinetic study using in situ titration with ammonia shows that the active sites for methanol dehydration are acidic and nonequivalent in comparison to redox and oxidative coupling. In situ FTIR spectroscopy reveals that adsorbed methoxy is the dominant surface species for all reactions, while the observed methanol dimer is found to be a spectator species through isotopic methanol exchange, supporting the dissociative mechanism for methanol dehydration via surface methoxy over TiO2 surfaces. Density functional theory calculations sho...
Proceedings of the 3rd ACM SIGCOMM conference on Internet measurement

The Internet is a demanding and stimulating object of study. Despite its increasingly central role in society, many basic questions about the properties of the Internet remain unanswered. On the one hand, it's sometimes surprising to nonspecialists that we need to measure the Internet at all, since it is an engineered artifact. But the Internet's prodigious size, decentralized design and evolution, and constant growth and change defeat any attempt at definitive description. As a result, those trying to obtain accurate knowledge about the nature of the Internet's infrastructure, protocols, applications, or dynamic behavior have found themselves faced with a wide variety of problems. The Internet Measurement Conference serves to bring together researchers attacking these challenging, and fascinating, problems.The increasing interest surrounding the field of Internet measurement has prompted a change in format this year: whereas previous Internet Measurement Workshops limited participation, this year the program moves to a Conference format with open participation. Hopefully this will provide an opportunity for even more researchers to actively engage with others in the field.The program you are holding is the result of a selective review process. The program committee received 109 submissions; from these, 32 papers were accepted (13 extended abstracts and 19 full papers) for an acceptance rate of 29%. The program committee meeting was held with all members in attendance either in person or by teleconference. Most reviews were provided by program committee members themselves; in some cases, outside experts were also consulted. The list of additional reviewers appears on a separate page in this program.Among the many excellent papers received, the program committee is pleased to single out "Inverting Sampled Traffic," by Nicolas Hohn and Darryl Veitch for special recognition as the Best Student Paper. In addition, four papers have been forwarded to IEEE/ACM Transactions on Networking for expedited consideration.
Determining Trace Gas Efflux from Container Production of Woody Nursery Crops

Agriculture is a large contributor of trace gas emissions and much of the work on reducing greenhouse gas (GHG) emissions has focused on row crops and pastures, as well as forestry and animal production systems; however, little emphasis has been placed on specialty crop industries such as horticulture. Our objective was to determine efflux patterns of CO2, CH4, and N2O associated with four different nursery container sizes [3.0 liter (trade gal; TG), 3.8 liter (#1; 1 gal), 7.6 liter (#2; 2 gal), and 11.4 liter (#3; 3 gal) using dwarf yaupon holly (Ilex vomitoria ‘Nana’ L.) grown under common production practices for one year. Weekly measurements indicated that carbon dioxide (CO2) and nitrous oxide (N2O) fluxes were highest in the largest containers (#3). There was a significant positive relationship between container size and CO2 efflux. Nitrous oxide efflux followed a similar pattern, except there were no differences between the two smallest container sizes. In general, CO2 and N2O fluxes increased with...
Brand personality and its impact on brand trust and brand commitment: an empirical study of luxury fashion brands

This study employed Aaker’s methodology to empirically investigate the personality of luxury fashion brands and explored the impact of brand personality on brand trust and brand commitment based on a sample of American consumers. Results of Study 1 revealed that American consumers perceive six distinct personality dimensions and 37 personality traits in luxury fashion brands. Study 2 validated the results from Study 1 and further clearly indicated that brand personality has a significant effect on both brand trust and brand commitment. The findings provide insights into the underlying values that consumers seek from luxury fashion consumption and lend a theoretical guidance to practitioners in the luxury fashion industry in their efforts to win customers’ brand commitment and loyalty.
Threshold conditions for a random laser mode

Stimulated emission in Nd 0.5 La 0.5 Al 3 (BO 3 ) 4 ceramic random laser was studied at different diameters of the pumped spot d. The developed heuristic model adequately describes the dependence of threshold pumping energy density versus d at d greater or equal to 150 micrometer. At small pumping beam diameter (less than 100 micrometer), very bright and strongly localized emission spot was observed in the center of the pumped area. The spectrum of the bright-spot emission appeared to be similar to that of 'continuum wave' light sources.