cssi/SciSciGPT-SciSciNet huggingface dataset:
Stem cells in neonatal medicine: An update

S cells are pluripotential cells that have the ability to differentiate into cell lineages that are determined by trophic factors and other biological cues. There is growing evidence in neonatal medicine which suggests understanding stem cell physiology may offer a unique pathway leading to decreased pathology. Researchers have proposed bone marrow-derived stem cell use in the treatment of chronic lung disease (Alphonse et al., 2012). In a similar fashion, mesenchymal stem cells also protected against lung disease (Tian et al., 2008). In these studies stem cells show a reparative mechanism that is currently not well described. Mesenchymal stem cells have also been shown to decrease cellular insults in an animal model of necrotizing enterocolitis (Tayman et al 20011). Stem cells have been administered intranasally and shown to have a protective effect on brain injury (van Velthaven 2010). Our laboratory has uncovered a potentially beneficial pathway that involves the biosynthesis of glutathione in stem cells. Most neonatal diseases involve some form of oxidative stress. Glutathione, a tripeptide, is the endogenous tool used to combat oxidative stress. This pathway involves the regulation of the cystine glutamate exchanger (System Xc) which controls the most critical step in glutathione biosynthesis. This pathway is one of the mechanisms that stem cells use to exert its’ protective effect.
Chip-package-board co-design for complex System-on-Chip (SoC)

Device scaling has allowed us to pack more functionality in a smaller die area. The ever increasing number of interfaces and the complexity of advanced SoCs force custom package design for almost every device rather than using a standard of the shelf package. The time-to-market window is shrinking with rapidly growing demand in the consumer market. To meet package performance with reduced package size and cost constraints, early evaluation of package and board routing is required. Floorplan of today's complex SoCs' is driven not only by the package but also board and overall system design. Chip-Package-Board co-design is obligatory to meet performance and schedule requirements as well as to reduce the system cost. This paper talks about the co-design challenges on a 40nm complex SoC implementation.
Measuring Fairness in Ranked Outputs

Ranking and scoring are ubiquitous. We consider the setting in which an institution, called a ranker, evaluates a set of individuals based on demographic, behavioral or other characteristics. The final output is a ranking that represents the relative quality of the individuals. While automatic and therefore seemingly objective, rankers can, and often do, discriminate against individuals and systematically disadvantage members of protected groups. This warrants a careful study of the fairness of a ranking scheme, to enable data science for social good applications, among others.In this paper we propose fairness measures for ranked outputs. We develop a data generation procedure that allows us to systematically control the degree of unfairness in the output, and study the behavior of our measures on these datasets. We then apply our proposed measures to several real datasets, and detect cases of bias. Finally, we show preliminary results of incorporating our ranked fairness measures into an optimization framework, and show potential for improving fairness of ranked outputs while maintaining accuracy.The code implementing all parts of this work is publicly available at https://github.com/DataResponsibly/FairRank.
INTRA-OPERATIVE MCL INJURY DURING TKA: A BRACING SOLUTION

Controversy remains regarding the optimal treatment for iatrogenic injury to the medial collateral ligament (MCL) during primary total knee arthroplasty (TKA). Some authors have recommended converting to a prosthesis that provides varus/valgus constraint while others have recommended primary repair. In this study, we report the results of 45 patients who sustained intra-operative MCL injuries during primary TKA that were treated with primary repair. Of 3922 consecutive primary TKA there were 48 (1.2%) intra-operative MCL lacerations or avulsions. One patient was lost and one died before 24 months follow up. All but one patient underwent primary repair with placement of components without varus/valgus constraint. This left 45 knees with a mean follow up of 89 months (range, 24 to 214 months). The mean HSS knee scores increased from 47 to 85 points (p Primary repair with 6 weeks of post-operative hinged bracing after iatrogenic injury to the MCL during primary TKA was successful at preventing instability although stiffness was seen in approximately 10% of patients. The increased morbidity associated with implantation of a semi-constrained or constrained implant may be unwarranted in this situation.
Local entropy of a nonequilibrium fermion system

The local entropy of a nonequilibrium system of independent fermions is investigated and analyzed in the context of the laws of thermodynamics. It is shown that the local temperature and chemical potential can only be expressed in terms of derivatives of the local entropy for linear deviations from local equilibrium. The first law of thermodynamics is shown to lead to an inequality, not equality, for the change in the local entropy as the nonequilibrium state of the system is changed. The maximum entropy principle (second law of thermodynamics) is proven: a nonequilibrium distribution has a local entropy less than or equal to a local equilibrium distribution satisfying the same constraints. It is shown that the local entropy of the system tends to zero when the local temperature tends to zero, consistent with the third law of thermodynamics.
Memory system reliability improvement through associative cache redundancy

The development of a VLSI device that provides memory system self-testing and redundancy without incurring the overhead penalties of error-correction coding or page-swapping techniques is described. This device isolates hard errors in system memory by writing a true and complement pattern to each system memory location. Locations from an on-chip fully associative cache are then mapped into the address space in place of faulty locations. Since substitutions take place at the memory word level, this method is more efficient than page swapping. Access to the onchip cache occurs in parallel with access to system memory, so memory access time is not increased, as it is with error detection and correction (EDAC). Analysis shows that this device can extend the mission time of a nonredundant memory system by as much as 35 times. >
Emergency Department Cardiopulmonary Evaluation of Low-Risk Chest Pain Patients with Self-Reported Stress and Anxiety

Abstract Background Chest pain is a high-risk emergency department (ED) chief complaint; the majority of clinical resources are directed toward detecting and treating cardiopulmonary emergencies. However, at follow-up, 80%–95% of these patients have only a symptom-based diagnosis; a large number have undiagnosed anxiety disorders. Objective Our aim was to measure the frequency of self-identified stress or anxiety among chest pain patients, and compare their pretest probabilities, care processes, and outcomes. Methods Patients were divided into two groups: explicitly self-reported anxiety and stress or not at 90-day follow-up, then compared on several variables: ultralow ( Results Eight hundred and forty-five patients were studied. Sixty-seven (8%) explicitly attributed their chest pain to “stress” or “anxiety”; their mean ACS pretest probability was 4% (95% confidence interval 2.9%–5.7%) and 49% (33/67) had ultralow pretest probability (0/33 with ACS or PE). None (0/67) were diagnosed with anxiety. Seven hundred and seventy-eight did not report stress or anxiety and, of these, 52% (403/778) had ultralow ACS pretest probability. Only one patient (0.2%; 1/403) was diagnosed with ACS and one patient (0.4%; 1/268) was diagnosed with PE. Patients with self-reported anxiety had similar radiation exposure, associated costs, and nearly identical (25.4% vs. 25.7%) ED recidivism to patients without reported anxiety. Conclusions Without prompting, 8% of patients self-identified “stress” or “anxiety” as the etiology for their chest pain. Most had low pretest probability, were over-investigated for ACS and PE, and not investigated for anxiety syndromes.
Corporate social responsibility and capital allocation efficiency

Abstract We investigate the relationship between corporate social responsibility (CSR) and firm-level capital allocation efficiency. Using seminal investment- Q framework, we provide evidence that CSR distorts investment sensitivity to Q . We further determine that this effect of CSR is moderated by the assumed level of agency conflict, stakeholder engagement, as well as financial slack. We also document that CSR negatively affects the sensitivity of external finance to Q and aggravates investment sensitivity to cash flow. In addition, we find that the distortion in the firm-level capital allocation efficiency is reflected in firm performance. Our findings are robust to alternative variable measurement as well as tests for endogeneity.
Critical Perspectives on Clandestine Migration Facilitation: An Overview of Migrant Smuggling Research:

Current representations of large movements of migrants and asylum seekers have become part of the global consciousness. Media viewers are bombarded with images of people from the global south ridin...
Adaptive Predictor-Based Output Feedback Control for a Class of Unknown MIMO Linear Systems

In this paper, the problem of characterizing adaptive output feedback control laws for a general class of unknown MIMO linear systems is considered. Specifically, the presented control approach relies on three components, i.e., a predictor, a reference model and a controller. The predictor is designed to predict the system’s output with arbitrary accuracy, for any admissible control input. Subsequently, a full state feedback control law is designed to control the predictor output to approach the reference system, while the reference system tracks the desired trajectory. Ultimately, the control objective of driving the actual system output to track the desired trajectories is achieved by showing that the system output, the predictor output and the reference system trajectories all converge to each other.
Lecture for the Fortieth Anniversary of Supergravity

In the first part of this lecture, some very basic ideas in supersymmetry and supergravity are presented at a level accessible to readers with modest background in quantum field theory and general relativity. The second part is an outline of a recent paper of the author and his collaborators on the AdS/CFT correspondence applied to the ABJM gauge theory with $\cal{N} =8$ supersymmetry.
PEMapper and PECaller Provide a Simplified Approach to Whole-Genome Sequencing

The analysis of human whole-genome sequencing data presents significant computational challenges. The sheer size of datasets places an enormous burden on computational, disk array, and network resources. Here, we present an integrated computational package, PEMapper/PECaller, that was designed specifically to minimize the burden on networks and disk arrays, create output files that are minimal in size, and run in a highly computationally efficient way, with the single goal of enabling whole-genome sequencing at scale. In addition to improved computational efficiency, we implement a statistical framework that allows for a base by base error model, allowing this package to perform as well or better than the widely used Genome Analysis Toolkit (GATK) in all key measures of performance on human whole-genome sequences.
Reforming and Restructuring Ukrzaliznytsia: A Crucial Task for Ukrainian Reformers

Purpose. This article examines options available for Ukraine as the country considers proposals to reform and restructure Ukrzaliznytsia. Methodology. The basic restructuring options observed internationally are presented, and the literature concerning their impacts and effectiveness is reviewed. Findings. The creation of competition among freight train companies has been found to improve system performance, but the EU policy prescription of complete vertical separation may not be required in order to achieve this. The Americas-style policy of horizontal separation has also been found to improve system performance, and may be more appropriate for a country as large as Ukraine and a railway as dependent on freight operations as Ukrzaliznytsia. Originality. Most of the literature on railways restructuring focuses on vertical separation or third party access, while the focus here is on a policy option arguably more appropriate to Ukraine. Practical value. Ukraine’s economy is dependent on the efficient shipment of bulk commodities such as coal, iron ore, steel, and grains – commodities that travel most economically over long distances by rail. The successful reform and restructuring of Ukrzaliznytsia will be a crucial part of Ukrainian economic reforms going forward.
Elevated Cholesterol in the Coxiella burnetii Intracellular Niche Is Bacteriolytic.

Coxiella burnetii is an intracellular bacterial pathogen and a significant cause of culture-negative endocarditis in the United States. Upon infection, the nascent Coxiella phagosome fuses with the host endocytic pathway to form a large lysosome-like vacuole called the parasitophorous vacuole (PV). The PV membrane is rich in sterols, and drugs perturbing host cell cholesterol homeostasis inhibit PV formation and bacterial growth. Using cholesterol supplementation of a cholesterol-free cell model system, we found smaller PVs and reduced Coxiella growth as cellular cholesterol concentration increased. Further, we observed in cells with cholesterol a significant number of nonfusogenic PVs that contained degraded bacteria, a phenotype not observed in cholesterol-free cells. Cholesterol had no effect on axenic Coxiella cultures, indicating that only intracellular bacteria are sensitive to cholesterol. Live-cell microscopy revealed that both plasma membrane-derived cholesterol and the exogenous cholesterol carrier protein low-density lipoprotein (LDL) traffic to the PV. To test the possibility that increasing PV cholesterol levels affects bacterial survival, infected cells were treated with U18666A, a drug that traps cholesterol in lysosomes and PVs. U18666A treatment led to PVs containing degraded bacteria and a significant loss in bacterial viability. The PV pH was significantly more acidic in cells with cholesterol or cells treated with U18666A, and the vacuolar ATPase inhibitor bafilomycin blocked cholesterol-induced PV acidification and bacterial death. Additionally, treatment of infected HeLa cells with several FDA-approved cholesterol-altering drugs led to a loss of bacterial viability, a phenotype also rescued by bafilomycin. Collectively, these data suggest that increasing PV cholesterol further acidifies the PV, leading to Coxiella death.IMPORTANCE The intracellular Gram-negative bacterium Coxiella burnetii is a significant cause of culture-negative infectious endocarditis, which can be fatal if untreated. The existing treatment strategy requires prolonged antibiotic treatment, with a 10-year mortality rate of 19% in treated patients. Therefore, new clinical therapies are needed and can be achieved by better understanding C. burnetii pathogenesis. Upon infection of host cells, C. burnetii grows within a specialized replication niche, the parasitophorous vacuole (PV). Recent data have linked cholesterol to intracellular C. burnetii growth and PV formation, leading us to further decipher the role of cholesterol during C. burnetii-host interaction. We observed that increasing PV cholesterol concentration leads to increased acidification of the PV and bacterial death. Further, treatment with FDA-approved drugs that alter host cholesterol homeostasis also killed C. burnetii through PV acidification. Our findings suggest that targeting host cholesterol metabolism might prove clinically efficacious in controlling C. burnetii infection.
Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer's disease in Vietnam Veterans using the Alzheimer's Disease Neuroimaging Initiative: Preliminary report

Introduction Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have previously been reported to be associated with increased risk of Alzheimer's disease (AD). We are using biomarkers to study Vietnam Veterans with/without mild cognitive impairment with a history of at least one TBI and/or ongoing PTSD to determine whether these contribute to the development of AD.
How Revolutions Shape (or Rather Blur) Markets: Initial Insights from the Arab Spring

How do revolutions shape markets? Prior social movement research has focused on those movements that seek to work with the existing state to change markets. Yet, revolutions are a unique type of so...
Geographic mobility among residents in seniors housing and care communities: Evidence from the Residents Financial Survey

ABSTRACTAlthough the elderly as a while show relatively little geographic migration in the U.S., we were interested in the geographic migration patterns among a specific subset of elderly that we know have moved out of the traditional family home—those living in assisted living and independent living communities. We analyze data from the Residents Financial Survey, a survey of 2,617 residents in assisted living and independent living communities that asked about their previous living arrangement, where they lived before moving to their current community, and how their care needs were previously met. We find there is substantial migration among respondents. Using self-reported and community-reported location and zip code information, we calculated whether people moved across state lines and we computed the distance people moved between their previous location and their current community. While the median distance moved is less than 10 miles, 20% moved across state lines and 21% of the sample moved more tha...
Early detection of promoted campaigns on social media

Social media expose millions of users every day to information campaigns - some emerging organically from grassroots activity, others sustained by advertising or other coordinated efforts. These campaigns contribute to the shaping of collective opinions. While most information campaigns are benign, some may be deployed for nefarious purposes, including terrorist propaganda, political astroturf, and financial market manipulation. It is therefore important to be able to detect whether a meme is being artificially promoted at the very moment it becomes wildly popular. This problem has important social implications and poses numerous technical challenges. As a first step, here we focus on discriminating between trending memes that are either organic or promoted by means of advertisement. The classification is not trivial: ads cause bursts of attention that can be easily mistaken for those of organic trends. We designed a machine learning framework to classify memes that have been labeled as trending on Twitter. After trending, we can rely on a large volume of activity data. Early detection, occurring immediately at trending time, is a more challenging problem due to the minimal volume of activity data that is available prior to trending. Our supervised learning framework exploits hundreds of time-varying features to capture changing network and diffusion patterns, content and sentiment information, timing signals, and user meta-data. We explore different methods for encoding feature time series. Using millions of tweets containing trending hashtags, we achieve 75% AUC score for early detection, increasing to above 95% after trending. We evaluate the robustness of the algorithms by introducing random temporal shifts on the trend time series. Feature selection analysis reveals that content cues provide consistently useful signals; user features are more informative for early detection, while network and timing features are more helpful once more data is available.
Pólya-based approximation for the ATM-forward implied volatility

We introduce a closed form approximation for the implied volatility of ATM-forward options. The relative error of this approximation is uniformly bounded for all option maturities and implied volatilities. The approximation is extremely precise, having relative error less than 10−6 for all options with integrated volatility less than 1.9, such as options with maturity less than three years and implied volatility less than 100%. Moreover, the approximate implied volatilities fall within the implied volatility bid–ask spread for all the liquid options, such as options with volatility less than 200% and maturity less than nine years.
Incentivizing Reliable Demand Response with Customers' Uncertainties and Capacity Planning

One of the major issues with the integration of renewable energy sources into the power grid is the increased uncertainty and variability that they bring. If this uncertainty is not sufficiently addressed, it will limit the further penetration of renewables into the grid and even result in blackouts. Compared to energy storage, Demand Response (DR) has advantages to provide reserves to the load serving entities (LSEs) in a cost-effective and environmentally friendly way. DR programs work by changing customers' loads when the power grid experiences a contingency such as a mismatch between supply and demand. Uncertainties from both the customer-side and LSE-side make designing algorithms for DR a major challenge. This paper makes the following main contributions: (i) We propose DR control policies based on the optimal structures of the offline solution. (ii) A distributed algorithm is developed for implementing the control policies without efficiency loss. (iii) We further offer an enhanced policy design by allowing flexibilities into the commitment level. (iv) We perform real world trace based numerical simulations which demonstrate that the proposed algorithms can achieve near optimal social cost. Details can be found in our extended version.
Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes.

Rap1-interacting adaptor molecule (RIAM) is a Rap1 effector that mediates the recruitment of talin to integrins, thereby supporting their activation. In this study, we investigated the role of RIAM in an adoptive transfer model for type I diabetes and report that RIAM expression in T cells is necessary for diabetes development. Loss of RIAM did not prevent lymphocyte recruitment to draining lymph nodes 24 h after transfer, but it was required for Ag-driven proliferation and cytotoxic killing. RIAM is recruited to immune synapses along with talin and LFA-1, and loss of RIAM profoundly suppresses Ag-dependent conjugate formation in primary naive and effector T cells. These data identify the requirement of RIAM for formation of immunological synapses and in resulting T cell functions in autoimmunity. Moreover, because RIAM-null mice are healthy, fertile, and display no bleeding abnormalities, our results identify RIAM and its regulators as potential targets for therapies of T cell–mediated autoimmunity.
Divide and Transfer: an Exploration of Segmented Transfer to Detect Wikipedia Vandalism.

The paper applies knowledge transfer methods to the problem of detecting Wikipedia vandalism detection, defined as malicious editing intended to compromise the integrity of the content of articles. A major challenge of detecting Wikipedia vandalism is the lack of a large amount of labeled training data. Knowledge transfer addresses this challenge by leveraging previously acquired knowledge from a source task. However, the characteristics of Wikipedia vandalism are heterogeneous, ranging from a small replacement of a letter to a massive deletion of text. Selecting an informative subset from the source task to avoid potential negative transfer becomes a primary concern given this heterogeneous nature. The paper explores knowledge transfer methods to generalize learned models from a heterogeneous dataset to a more uniform dataset while avoiding negative transfer. The two novel segmented transfer (ST) approaches map unlabeled data from the target task to the most related cluster from the source task, classifying the unlabeled data using the most relevant learned models.
Improved User Position Monitor for WAAS

This paper describes an efficient new algorithm being developed for the Wide Area Augmentation System (WAAS) that significantly improves its ability to detect threats arising from multiple simultaneous one to two sigma errors. This new algorithm is based on the sum of the squares of the normalized errors at each reference station. It has significantly improved the ability to detect error conditions that are not obviously faulted individually, but that could be harmful to users when combined. Currently, other monitors are inflating the confidence bounds to protect against such conditions. This new User Position Monitor (UPM) is able to identify such threats, and as a consequence, excess conservatism may be removed from the system. We expect this innovation to lead to better availability while maintaining equal or better levels of integrity. Copyright © 2017 Institute of Navigation
Data Access for LIGO on the OSG

During 2015 and 2016, the Laser Interferometer Gravitational-Wave Observatory (LIGO) conducted a three-month observing campaign. These observations delivered the first direct detection of gravitational waves from binary black hole mergers. To search for these signals, the LIGO Scientific Collaboration uses the PyCBC search pipeline. To deliver science results in a timely manner, LIGO collaborated with the Open Science Grid (OSG) to distribute the required computation across a series of dedicated, opportunistic, and allocated resources. To deliver the petabytes necessary for such a large-scale computation, our team deployed a distributed data access infrastructure based on the XRootD server suite and the CernVM File System (CVMFS). This data access strategy grew from simply accessing remote storage to a POSIX-based interface underpinned by distributed, secure caches across the OSG.
Secrecy in Multiagent Systems

We introduce a general framework for reasoning about secrecy requirements in multiagent systems. Our definitions extend earlier definitions of secrecy and nondeducibility given by Shannon and Sutherland. Roughly speaking, one agent maintains secrecy with respect to another if the second agent cannot rule out any possibilities for the behavior or state of the first agent. We show that the framework can handle probability and nondeterminism in a clean way, is useful for reasoning about asynchronous systems as well as synchronous systems, and suggests generalizations of secrecy that may be useful for dealing with issues such as resource-bounded reasoning. We also show that a number of well-known attempts to characterize the absence of information flow are special cases of our definitions of secrecy.
Investigation and development of friction stir welding process for unreinforced polyphenylene sulfide and reinforced polyetheretherketone

The joining of thermoplastics through welding offers numerous advantages over mechanical joining. Most importantly, it eliminates the use of costly fasteners and has only a limited effect on the st...
Using Instance Texts to Improve Keyword-Based Class Retrieval.

In this paper we investigate the keyword based class retrieval problem, which we define as how to identify ontological classes that best match a keyword based query. Most previous applications use simple syntactic matching approaches on the class labels and/or comments, or expand the keyword query by using lexicons such as Word Net, but fail to retrieve relevant resources in many scenarios. Instead of relying on external sources, we investigate this problem by using the annotations of instances associated with classes in the knowledge base. We propose a general framework of this approach, which consists of two phases: the keyword query is first used to locate relevant instances, then we induce the classes given this list of weighted matched instances. If we identify sufficient text for the instances, then the first phase can be solved by a traditional information retrieval (IR) query, however the second phase might be cast in different ways: as an additive value function, as an IR problem with instance as queries, or as an instance-based ontology alignment problem. With many applicable strategies initiated from different viewpoints, we find that some of them are mathematically equivalent or very similar. In the experiments we compare our proposed framework to simple syntactic approaches and evaluate different strategies.
Improved Traffic System Integration Through Software Simulation

Abstract Modern traffic control devices and traffic management systems designs have become increasingly sophisticated by integrating hardware and software components to solve specific real-time control and monitoring problems. This paper describes an innovative, integrated testing procedures for system verification and validation. This process is used in the implementation of a truck warning device for operational safety on directional freeway interchange ramps. The system has been implemented successfully at the interchange located at US 59 and Loop 610 in Houston, Texas.
Improving Reading Comprehension with Automatically Generated Cloze Item Practice

This study investigated the effect of cloze item practice on reading comprehension, where cloze items were either created by humans, by machine using natural language processing techniques, or randomly. Participants from Amazon Mechanical Turk (\(N=302\)) took a pre-test, read a text, and took part in one of five conditions, Do-Nothing, Re-Read, Human Cloze, Machine Cloze, or Random Cloze, followed by a 24-hour retention interval and post-test. Participants used the MoFaCTS system [27], which in cloze conditions presented items adaptively based on individual success with each item. Analysis revealed that only Machine Cloze was significantly higher than the Do-Nothing condition on post-test, \(d=.58\), \(CI_{95} [.21,.94]\). Additionally, Machine Cloze was significantly higher than Human and Random Cloze conditions on post-test, \(d=.49\), \(CI_{95} [.12,.86]\) and \(d=.71\), \(CI_{95} [.34,1.09]\) respectively. These results suggest that Machine Cloze items generated using natural language processing techniques are effective for enhancing reading comprehension when delivered by an adaptive practice scheduling system.
A Flexible Procedure for Multiple Cadaveric Organ Procurement

Techniques have been developed which permit removal of the kidneys, liver, heart and other organs from the same donor without jeopardy to any of the individual grafts. The guiding principle is avoidance with all organs of warm ischemia. This is achieved by carefully timed and controlled infusion of cold solutions into anatomic regions, the limits of which are defined by preliminary dissection.
A pesticide paradox: fungicides indirectly increase fungal infections.

There are many examples where the use of chemicals have had profound unintended consequences, such as fertilizers reducing crop yields (paradox of enrichment) and insecticides increasing insect pests (by reducing natural biocontrol). Recently, the application of agrochemicals, such as agricultural disinfectants and fungicides, has been explored as an approach to curb the pathogenic fungus, Batrachochytrium dendrobatidis (Bd), which is associated with worldwide amphibian declines. However, the long-term, net effects of early-life exposure to these chemicals on amphibian disease risk have not been thoroughly investigated. Using a combination of laboratory experiments and analysis of data from the literature, we explored the effects of fungicide exposure on Bd infections in two frog species. Extremely low concentrations of the fungicides azoxystrobin, chlorothalonil, and mancozeb were directly toxic to Bd in culture. However, estimated environmental concentrations of the fungicides did not reduce Bd on Cuban tree frog (Osteopilus septentrionalis) tadpoles exposed simultaneously to any of these fungicides and Bd, and fungicide exposure actually increased Bd-induced mortality. Additionally, exposure to any of these fungicides as tadpoles resulted in higher Bd abundance and greater Bd-induced mortality when challenged with Bd post-metamorphosis, an average of 71 d after their last fungicide exposure. Analysis of data from the literature revealed that previous exposure to the fungicide itraconazole, which is commonly used to clear Bd infections, made the critically endangered booroolong frog (Litoria booroolongensis) more susceptible to Bd. Finally, a field survey revealed that Bd prevalence was positively associated with concentrations of fungicides in ponds. Although fungicides show promise for controlling Bd, these results suggest that, if fungicides do not completely eliminate Bd or if Bd recolonizes, exposure to fungicides has the potential to do more harm than good. To ensure that fungicide applications have the intended consequence of curbing amphibian declines, researchers must identify which fungicides do not compromise the pathogen resistance mechanisms of amphibians.
Prostate Specific Antigen and Acid Phosphatase-Reactive Cells in Cystitis Cystica and Glandularis

Cystitis cystica (CC) and cystitis glandularis (CG) are common in the urothelium lining the bladder neck and trigone. Because some cases of CG show histologic features strikingly similar to prostatic acini, we hypothesized that some such foci may represent prostatelike metaplasia in the urinary bladder. Forty surgical and autopsy bladder specimens (23 males, 17 females) showing CC or CG were studied using anti-prostate specific antigen and anti-prostate specific acid phosphatase antibodies. Fourteen (35%) of these 40 cases showed positive staining for prostate specific antigen or prostate specific acid phosphatase or both in CC or CG foci. Among these were five female patients. The findings indicate that bladder epithelium is capable of undergoing prostatelike metaplasia and lend support to the hypothesis that the adult bladder stroma closest to the prostate may exert inductive influences on the overlying epithelium to show prostatelike metaplasia.
Computed Tomography of Primary Retroperitoneal Malignancies

The CT examinations and medical records of 33 patients with primary retroperitoneal malignancies were reviewed. Computed tomography findings were then compared with those from scans performed on 122 patients with non-Hodgkin lymphoma who presented during the same time interval. Primary retroperitoneal neoplasms had three distinct CT appearances. Twenty-one patients (64%) had large soft tissue masses. Seven patients (21%) had masses with fatty density components, and five patients (15%) had tumors that were primarily of water attenuation. With the exception of those liposarcomas that contained recognizable fat, CT could not distinguish among the different cell types. Seventeen patients with non-Hodgkin lymphoma had large dominant retroperitoneal soft tissue masses that resembled primary retroperitoneal malignancies. In most cases, however, CT was able to differentiate these tumor masses from primary retroperitoneal tumors. Although 19 of 20 sarcomas of soft tissue attenuation were heterogeneous, only six of the 17 lymphomas presenting as dominant masses had such an appearance. Computed tomography is extremely helpful in initially evaluating patients with primary retroperitoneal tumors and in assisting the surgeon in planning his or her approach by accurately defining tumor extent.
Current Status of Rubella Testing. A Report Based on Data From the College of American Pathologists’ Surveys, 1978-1980

Data from national survey programs were used to define selected attributes of popular rubella methods. Of those participating in the College of American Pathologists' survey, 47% used passive hemagglutination (PHA); 45% used hemagglutination-inhibition (HI), 7% used indirect immunofluorescence, and less than 1% used enzyme immunosorbent assays for rubella testing. Enzyme assays were not evaluated. The other methods had sensitivities and specificities exceeding 94% and 88%, respectively. The predictive value of a negative test was used to identify differences among the various methods. The HI tests using human O cells had a 90-95% prediction rate for a true-negative result. Indirect immunofluorescence, PHA, and HI using kaolin had the lowest predictive values (68-72%) values for other methods were intermediate. Levels of reactivity also differed. The HI methods using human O cells yielded higher titers than did the reference method (1- to 3-day-old chick/heparin MnCl2), while the titers for HI methods using kaolin tended to be lower.
The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in Caenorhabditis elegans

Gq is a heterotrimeric G protein that is widely expressed in neurons and regulates neuronal activity. To identify pathways regulating neuronal Gq signaling, we performed a forward genetic screen in Caenorhabditis elegans for suppressors of activated Gq. One of the suppressors is an allele of sek-1, which encodes a mitogen-activated protein kinase kinase (MAPKK) in the p38 MAPK pathway. Here, we show that sek-1 mutants have a slow locomotion rate and that sek-1 acts in acetylcholine neurons to modulate both locomotion rate and Gq signaling. Furthermore, we find that sek-1 acts in mature neurons to modulate locomotion. Using genetic and behavioral approaches, we demonstrate that other components of the p38 MAPK pathway also play a positive role in modulating locomotion and Gq signaling. Finally, we find that mutants in the SEK-1 p38 MAPK pathway partially suppress an activated mutant of the sodium leak channel, NCA-1/NALCN, a downstream target of Gq signaling. Our results suggest that the SEK-1 p38 pathway may modulate the output of Gq signaling through NCA-1(unc-77).
Strain-stiffening gels based on latent crosslinking

Gels represent an increasingly important class of soft materials with applications ranging from regenerative medicine to commodity materials. However, gels typically exhibit relative mechanical weakness, which worsens under repeated strain. Here we report a new class of responsive gels with latent crosslinking moieties that exhibit strain-stiffening behavior. This property results from the lability of disulfides, initially isolated in a protected state, then activated to crosslink on-demand. The thiol groups are induced to form inter-chain crosslinks when subjected to mechanical compression, resulting in a gel that strengthens under strain. Molecular shielding design elements regulate the strain-sensitivity and spontaneous crosslinking tendencies of the polymer network. These strain-responsive gels represent a rational design of new advanced materials with on-demand stiffening properties and potential applications in elastomers, adhesives, foams, films, and fibers.
Eruptive event generator based on the Gibson-Low magnetic configuration

Coronal Mass Ejections (CMEs), a kind of energetic solar eruptions, are an integral subject of space weather research. Numerical magnetohydrodynamic (MHD) modeling, which requires powerful computational resources, is one of the primary means of studying the phenomenon. With increasing accessibility of such resources, grows the demand for user-friendly tools that would facilitate the process of simulating CMEs for scientific and operational purposes. The Eruptive Event Generator based on Gibson-Low flux rope (EEGGL), a new publicly available computational model presented in this paper, is an effort to meet this demand. EEGGL allows one to compute the parameters of a model flux rope driving a CME via an intuitive graphical user interface (GUI). We provide a brief overview of the physical principles behind EEGGL and its functionality. Ways towards future improvements of the tool are outlined.
Using neural networks for reducing the dimensions of single-cell RNA-Seq data

While only recently developed, the ability to profile expression data in single cells (scRNA-Seq) has already led to several important studies and findings. However, this technology has also raised several new computational challenges. These include questions about the best methods for clustering scRNA-Seq data, how to identify unique group of cells in such experiments, and how to determine the state or function of specific cells based on their expression profile. To address these issues we develop and test a method based on neural networks (NN) for the analysis and retrieval of single cell RNA-Seq data. We tested various NN architectures, some of which incorporate prior biological knowledge, and used these to obtain a reduced dimension representation of the single cell expression data. We show that the NN method improves upon prior methods in both, the ability to correctly group cells in experiments not used in the training and the ability to correctly infer cell type or state by querying a database of tens of thousands of single cell profiles. Such database queries (which can be performed using our web server) will enable researchers to better characterize cells when analyzing heterogeneous scRNA-Seq samples.
Metastatic Cardiac Angiosarcoma to the Lung, Spine, and Brain: A Case Report and Review of the Literature.

Background Metastatic angiosarcoma to the brain is a rare entity without an established management protocol. Case Description A man with primary cardiac angiosarcoma presented with a rare brain metastasis. The patient underwent successful resection of the brain metastasis and was initiated on chemotherapy only for his systemic disease. The patient did not develop local recurrence. A review of primary and metastatic central nervous system angiosarcoma, its pathologic features, clinical disease course, treatment strategies, and genomics is also provided. Conclusions Angiosarcomas are rare tumors that are difficult to treat. Gross total resection of a central nervous system metastasis is recommended before initiation of adjuvant chemotherapy or radiation therapy. Close follow-up is still required given the propensity for continued metastasis of these tumors. Future treatments may be developed based on the genomics of angiosarcomas.
Charge Transfer Effects in Surface Enhanced Raman Scattering

Abstract Surface enhanced Raman scattering (SERS) due to charge transfer interactions between the adsorbed molecule and the metal surface is analyzed using the semiempirical Wolfsberg-Helmholz method1 to relate the molecule-surface interactions and the resulting charge transfer states to the overlap integrals between the metal conduction-band orbitals and an acceptor or donor molecular orbital of the molecule. Calculations for the model system of ethylene adsorbed on silver (approximated as a simple cubic metal with tight binding wave functions constructed from Ag 5s valence orbitals), with charge-transfer excitation of an electron from the metal to the antibonding ethylene π orbital, show that charge-transfer Raman enhancements of the order of 10 to 1000 are possible if the charge-transfer band is partially resonant with the exciting radiation. The net enhancement is the product of the charge-transfer gain and the electrodynamic enhancement due to plasmon resonances at surface roughness elements. Symmetric vibrations usually will be enhanced substantially more than nonsymmetric ones by charge-transfer because, in contrast to non-resonant Raman scattering, the vibrational coupling is primarily Franck- Condon (due to differences in the equilibrium nuclear configurations of the ground and excited charge transfer states and the resulting nonorthogonality of different vibrational sublevels of these states) rather than Herzberg-Teller (due to vibrationally induced changes in the electronic wave functions). The charge-transfer mechanism is selective with the most enhanced vibrations involving those atoms which experience the greatest change in electron density between the ground and excited charge-transfer state. A recent report of SERS for benzene on platinum,2 strongly suggests charge-transfer enhancement because the electromagnetic-field-enhancing plasmon resonances are strongly damped in this metal. The complete paper will be published in the December 1, 1982 issue of the Journal of Chemical Physics.
SIMULTANEOUS BILATERAL TOTAL KNEE ARTHROPLASTY: DOES IT HAVE A PLACE?

Bilateral one stage total knee replacement (TKR) has a number of advantages. There is one operative procedure and anesthetic and overall recovery time is significantly reduced. It is a more cost-effective procedure in that acute hospital stay is less and although rehabilitation time is greater in the short term, overall it is less. Additionally, if there is a bilateral flexion contracture present there is an inevitable loss of extension if a single knee is operated upon as this knee will assume the position of the unoperated knee. Patients greatly prefer having both knees corrected at one operative setting rather than having to have the inconvenience and pain associated with a second operative procedure at three to six months after the first one. There are potential disadvantages to a one stage procedure. One concern has been that there is more peri-operative morbidity associated with one stage bilateral total knee replacement. In a review of 501 patients undergoing bilateral one stage total knee replacement at the Hospital for Special Surgery (HSS) there were no peri-operative deaths, myocardial infarctions or cerebrovascular accidents. There were arrhythmias present in 5% of patients. Fat emboli were present in 3% and 2 patients (0.4%) had pulmonary emboli. The average transfusion requirement was 2.6 units and allogeneic blood was required in 42%. There were 2 deep infections, 3 hematomas and 5 patients with delayed wound healing There was an increased incidence of major complications in patients with ASA classification 3 and with increasing age over 70 years. New data indicates peri-operative administration of hydrocortisone may mitigate lung injury as demonstrated by reduction in cytokine and desmosine levels in a randomised trial. There was also a trend toward less need for narcotic medication and better range of motion in the steroid treated group Patient selection is important and all patients are screened pre-operatively by an internist and anesthesiologist. In over 3000 bilateral TKRs at HSS infection rate and mortality were lower than in the unilateral total knee replacement patients. Much of this is due to patient selection criteria. All patients underwent the procedure with epidural anesthesia with post-operative epidural PCA for 48 hours. All patients are discharged on warfarin and spend the operative night in the recovery room. The procedure has acceptable morbidity and great advantage in properly selected patients.