cssi/SciSciGPT-SciSciNet huggingface dataset:
Design of a Next Generation High-Speed Data Bus

Future space and military applications, such as, NASA space exploration missions, will require high-bandwidth but dependable avionics architectures for on-board mission-critical processing and aggregate information exchange among subsystems. This paper is to present a design process that we at Honeywell Labs have used to design next generation high-speed avionics with open system architecture. The process begins with review of prior arts and collection of voice of customers. Candidate open source technologies are then identifled by a Six-Sigma based study, followed by a failure mode and efiect analysis to select and deflne a proof-of-concept system architecture. The proof-of-concept architecture is evaluated, validated, and reflned using OpNet Modeler simulations. In the context of this paper, we use IEEE-1394b based avionics design as an example to describe this process.
Effect of BAL on Experimental Polyarthritis of Rats.

ConclusionsBAL (2:3-dimercaptopropanol), administered to rats with polyarthritis produced by infection with L-4 strain of pleuropneumonia-like microorganism, causes a significant increase in incidence of arthritis, a more extensive type of joint involvement, and a slightly decreased rate of survival. Concentrations of BAL up to 0.2 mg per cc of broth failed to inhibit or to increase the growth of pleuropneumonia-like organisms in vitro. It is suggested that BAL in the low concentrations used in vivo may act by furnishing sulfhydryl groups needed in the metabolism of the microorganisms, and thus aggravate the polyarthritis, rather than by poisoning by animals and thus reducing their resistance to the infection.
Chemical Vapor Deposition Route to the Fabrication of thin Films of High Temperature Oxide Superconductors

High quality Y‐Ba‐Cu‐O thin films were produced by metal‐organic chemical vapor deposition (MOCVD) using metal chelates of P‐diketonate ligands. The films were grown in a cold‐wall CVD reactor at a reactor pressure of 10 torr and substrate temperature in the range 450‐550°C. Characterization studies were performed using Rutherford Backscattering (RBS), Auger electron spectroscopy (AES), scanning electron microscopy (SEM), and energy‐dispersive x‐ray spectroscopy (EDXS). These studies showed that the films were uniform, continuous, adherent and highly pure—carbon and fluorine contents were below the detection limits of the techniques used. Four point resistivity measurements showed that the films had a sharp superconducting transition at 9OK and exhibited current densities of ‐3x10 5 A/cm 2 (B=0, T=65K) . The Y‐Ba‐Cu‐0 films thus grown were subsequently compared to radio‐frequency (rf) sputtered Y‐Ba‐Cu‐O films. It was found that the MOCVD‐produced films were superior in terms of uniformity, adherence, and electrical properties.
Comparative Effectiveness of Hepatic Artery Based Therapies for Unresectable Colorectal Liver Metastases: A Meta-Analysis

Background Patients with unresectable Colorectal Liver Metastases (CRLM) are increasingly being managed using Hepatic Artery Based Therapies (HAT), including Hepatic Arterial Infusion (HAI), Radioembolization (RE), and Transcatheter Arterial Chemoembolization (TACE). Limited data is available on the comparative effectiveness of these options. We hypothesized that outcomes in terms of survival and toxicity were equivalent across the three strategies. Methods A meta-analysis was performed using a prospectively registered search strategy at PROSPERO (CRD42013003861) that utilized studies from PubMed (2003–2013). Primary outcome was median overall survival (OS). Secondary outcomes were treatment toxicity, tumor response, and conversion of the tumor to resectable. Additional covariates included prior or concurrent systemic therapy. Results Of 491 studies screened, 90 were selected for analyses—52 (n = 3,000 patients) HAI, 24 (n = 1,268) RE, 14 (n = 1,038) TACE. The median OS (95% CI) for patients receiving HAT in the first-line were RE 29.4 vs. HAI 21.4 vs. TACE 15.2 months (p = 0.97, 0.69 respectively). For patients failing at least one line of prior systemic therapy, the survival outcomes were TACE 21.3 (20.6–22.4) months vs. HAI 13.2 (12.2–14.2) months vs. RE 10.7 (9.5–12.0). Grade 3–4 toxicity for HAT alone was 40% in the HAI group, 19% in the RE group, and 18% in the TACE groups, which was increased with the addition of systemic chemotherapy. Level 1 evidence was available in 5 studies for HAI, 2 studies for RE and 1 for TACE. Conclusion HAI, RE, and TACE are equally effective in patients with unresectable CRLM with marginal differences in survival.
Concordance in peer victimization-related beliefs across parents and in-service and preservice early childhood teachers

ABSTRACTThe present study examined differences in the victimization-related beliefs of 173 adults (65 early childhood preservice teachers, 62 early childhood in-service teachers, and 46 parents). Additionally, confidence about managing victimization was evaluated as a predictor of proposed responses to negative peer encounters. In-service teachers were more likely to endorse the belief that peer victimization is a normal part of childhood and reported a stronger endorsement of assertiveness in response to it than preservice teachers. Parents had the highest avoidance beliefs, followed by in-service teachers. Group status positively predicted advising independent coping, with in-service teachers being more likely than preservice teachers to encourage independent coping in response to victimization. Findings provide evidence about victimization beliefs and proposed responses of parents and experienced and novice early childhood teachers and could contribute to anti-bullying efforts directed specifically at ...
Genetic disorders in adolescents and young adults.

While the nature of the environmental changes which trigger the expression of certain genetic disorders in adolescence is not completely understood, the metabolic and hormonal changes associated with sexual maturation probably have an important role. Examples of chromosomal abnormalities which may become evident in adolescence include Klinefelter's syndrome and Turner's syndrome. Two groups of gene abnormalities are given special emphasis: gene mutations expressed as abnormalities in sexual development, and those expressed as neurologic disorders.
Extended-Cycle Elutriation to Adjust T-Cell Content in HLA-Disparate Bone Marrow Transplantation

We report the development of a double-cycle elutriation (DCE) technique separating 3 or greater logs of T cells from a stem-cell-enriched marrow fraction and the results of phase I T-cell depletion studies with HLA-disparate related bone marrow transplantation (BMT) donors in two patient groups. In group 1, 10 patients with refractory hematopoietic malignancies received combination chemotherapy, total body irradiation (TBI), and immunosuppression (pre- and post-BMT), and hematopoietic rescue with a marrow transplant, depleted of T cells by elutriation. Potentially to promote engraftment and a graft-versus- leukemia (GVL) effect, 0.5 to 0.75 x 10(5) T cells/kg were added back. All 10 patients engrafted. Five patients developed acute graft-versus- host disease (GVHD; four grade II, one grade III) and two subsequently developed chronic GVHD. Two patients have relapsed (median follow-up, 206 days; range, 46 to 1,035). Four patients died of BMT-related complications (three of infection, one of veno-occlusive disease [VOD]). Four patient are disease-free survivors (median follow-up, 960 days; range, 670 to 1,035). Group 2 included five infants, four with congenital lymphohematopoietic deficiencies and one with refractory acute lymphocytic leukemia (ALL). In these infants, busulfan and increased cyclophosphamide were substituted for TBI. Only the ALL patient received added T cells. Three patients engrafted: one has stable mixed chimerism, one relapsed with ALL, and one rejected the marrow. One patient had primary autologous recovery, while another failed to engraft. None developed GVHD. We conclude that, in this setting of HLA-disparate BMT with post-BMT antithymocyte globulin (ATG) and corticosteroids, DCE significantly depletes T cells from the marrow and that a defined number of T cells can be added without the occurrence of severe GVHD.
A factor-analytic study of simplicity-complexity of social ordering.

From 80 college sophomores were obtained three measures of simplicity-complexity of social ordering: number of discriminable categories along scales of discrimination applied to persons, number of different bi-polar scales used to discriminate among persons and a rating scale of the level of abstraction of descriptions of a single Other person. Nine attitude measures were given: acceptance vs rejection of change, dogmatism, self-reliance, rationalism, purpose-fulness, rejection of people, abstract sex standard, concrete sex standard, and authoritarianism. The Taylor Manifest Anxiety Scale was also given. Three factors which accounted for a total of 89% of the common variance were interpreted. These factors were: (A) Rejection-Acceptance of attitude positions and social stimuli tending to threaten or change the perceptual ordering and belief systems, (B) The imposition of rational, dichotomous order and suppression of spontaneous experiencing to achieve a future goal, and (C) Simplicity-Complexity of socia...
NA+-K+-ATPASE IN ADIPOCYTE DIFFERENTIATION IN CULTURE

Differentiation of 3T3-L1 cells from a fibroblast to an adipocyte phenotype results in an approximately 50% decline in Na(+)-K(+)-ATPase activity and ouabain-sensitive 86Rb uptake. Kinetic analysis revealed a K 1/2 for Na+ of approximately 14 mM, a Km for ATP of approximately 0.4 mM, and maximal activation by sodium dodecyl sulfate at a 0.05 (wt/wt) detergent/protein ratio in both mature fibroblasts and adipocytes. Both fibroblasts and adipocytes exhibited Na(+)-K(+)-ATPase activity with an inhibition constant (Ki) for ouabain of approximately 10(-4) M. In addition, adipocytes exhibited a second component representing 30% of total activity with a Ki of approximately 5 x 10(-7) M. The emergence of biphasic ouabain inhibition kinetics in adipocytes raised the possibility of a change in alpha-subunit isoform composition with cytodifferentiation. This inference was evaluated by isoform-specific mRNA analysis (Northern blots) and by alpha-isoform-specific immunoassays (Western blots). Northern blots revealed a modest decrease in mRNA alpha 1, a striking increase in mRNA alpha 2, and a significant loss of mRNA beta content with differentiation of fibroblasts to adipocytes. By immunoassay, fibroblasts exhibited the alpha 1-isoform. Adipocytes exhibited an admixture of alpha 1- and alpha 2-isoforms, with alpha 2 being the more abundant isoform. There was no one-to-one correspondence either between the mRNA isoform and alpha-subunit abundances or between alpha-subunit abundances and enzymatic activity, suggesting that regulation occurs at multiple levels in this system. Findings indicate, however, that a shift in alpha-isoform composition accompanied by a change in ouabain inhibition kinetics occurs with cytodifferentiation.
Advances in Economics and Econometrics: Giving and Receiving Advice

This paper reviews literature on communication between informed experts and uninformed decision makers. The research provides some insight into what constitutes a persuasive statement and under what conditions a decision maker will benefit from consulting an expert. I classify the literature along four dimensions: strategic, technological, institutional, and cultural. To the extent that decision makers and experts have different preferences, communication creates strategic problems. Technological considerations describe the domain of uncertainty, the cost of acquiring information, and the cost of manipulating information. The institution determines who has responsibility for making decisions and the rules that govern communication. Cultural factors describe the way in which agents interpret language.
Family at the Margins: State, Welfare and Well-being in Japan

The articles in this special section address the stakes for welfare and well-being when normative ideas surrounding family intersect with state policy and practice in Japan. The central argument mo...
Post-traumatic syringomyelia with holocord involvement: a case report.

Syringomyelia is a disorder in which a cyst, or syrinx, develops within the spinal cord. Historically, syringomyelia in post-traumatic spinal cord injury has been uncommon; however, its diagnosis has been increasing due to the advances in medical technology. Syringomyelia that involves the entire spinal cord, or holocord, is rare after traumatic spinal cord injury, with only a few cases reported in the literature. We present a case of a 57-year-old male who had a motorcycle accident 30 years ago resulting in a spinal cord injury, who presented a rapid decline in the function of his left upper extremity. Imaging studies were reviewed to reveal an expansive T2 hyperintense intramedullary spinal cord lesion from C1 inferiorly to the conus medullaris. The patient underwent a T6–T7 laminectomy for the placement of a syringosubarachnoid shunt. The patient was then transferred to acute inpatient rehabilitation where he underwent an intense course of therapy for 3 weeks while being monitored closely by physiatrists. The patient was able to make significant recovery and was successfully discharged home. There are a limited number of reports published about post-traumatic holocord syringomyelia. It is important to recognize this diagnosis during follow-up visits with spinal cord injury patients.
How Voluntary Environmental Programs Reduce Pollution

This article investigates the mechanisms that voluntary environmental program (VEP) participants adopt to reduce pollution. The focus of this article is the 33/50 program, a VEP introduced by the U.S. Environmental Protection Agency in 1991 and discontinued in 1995. The program called for emissions reductions for 17 chemicals reported to the Toxics Release Inventory. Using a sample of approximately 12,000 plants, the relationship between 33/50 program participation and adoption of pollution reduction practices is studied for three time periods, 1991–1995 (program life), 1996–2004, and 2005–2013. These practices include source reduction activities (SRAs) and recycling, recovery, and treatment (RRTs). The major findings are that during the program's life, 33/50 participants showed increased adoption of SRAs and RRTs for both targeted and nontargeted chemicals. However, once the program ended, higher adoption rates persisted for RRTs only, with a shift in emphasis toward treatment over recycling and recovery.
Automated microfluidic plant chips-based plant phenotyping system

We report on the development of an enhanced and robust microfluidic plant chip-based growth and monitoring system for high-throughput phenotyping of Arabidopsis thaliana. The system consists of multiple vertical plant chips, a microfluidic hormone concentration gradient generator, multiple simple gravity pumps, and a robotic arm with a stereoscope for plant imaging. We validate this system by phenotyping the growth of Arabidopsis plants in medium containing different hormone concentrations, in a real-time manner. Our results show that Arabidopsis growth and hormone response in this system closely replicates growth on standard laboratory petri plates.
Chills and Chuckles: The Effects of Program Context on Viewer Responses to Television Advertising

Consumers do not encounter television advertising in a “vacuum.” Rather, television advertising is typically seen in a programming context where it competes with program material for the viewer’s limited attentional capacity. Programming contexts, the environments within which commercials are embedded, vary enormously: news programs, comedies, dramas, soap operas, music television, educational programming and so on. It is plausible to assume that the content and impact of the programming environment influences whether and how embedded advertising messages are processed. The research reported in this paper is concerned with the emotional impact of program context and its effects on viewer responses to commercials presented in that viewing context. If a program environment influences the effectiveness of commercials, then it should be taken into account in media selection and also in creative and placement strategies so as to increase commercial effectiveness.
Utilization and Tolerance of Intravenous Fat Emulsions

Emulsions of fat have been the subject of much research in the field of parenteral nutrition because they offer a concentrated source of calories in a moderate volume without the complications of hypertonic solutions. It is generally accepted that a suitable emulsion would be highly desirable in those instances where caloric requirements are high and excessive amounts of fluid must be avoided. Much of the effort in this area during the past three or four decades has been devoted to proving intravenously administered fat is utilized, is efficacious, and is devoid of serious reactions when properly formulated (Geyer, 1960; Wretlind, 1972; Geyer, 1970). This presentation is concerned with the utilization and tolerance of parenteral fat emulsions.
Vascular type 1 angiotensin receptors control blood pressure by augmenting peripheral vascular resistance in female mice

Angiotensin II (ANG II) is a major mediator of hypertension pathogenesis. In addition, there are well-documented differences in expression of the renin-angiotensin system (RAS) components and ANG II responses between males and females, which may explain sex differences in blood pressure (BP) and hypertension epidemiology. We previously showed that type 1A angiotensin (AT1A) receptors in vascular smooth muscle cells (VSMCs) play a critical role in BP regulation and hypertension pathogenesis, but these studies were carried out in male mice. Therefore, the major goal of the current studies was to examine the impact of VSMC AT1A receptors on BP and hypertension pathogenesis in female mice. We found that elimination of VSMC AT1A receptors in female mice reduced (≈8 mmHg) baseline BP without altering sodium sensitivity. The severity of ANG II-induced hypertension was diminished (≈33% reduction in BP), particularly during the last 2 wk of chronic ANG II infusion, compared with controls, but natriuresis was not altered during the first 5 days of ANG II infusion. Urinary norepinephrine levels were enhanced in female SMKO compared with control mice. There was a virtually complete elimination of ANG II-induced kidney hemodynamic responses with attenuation of acute vasoconstrictor responses in the systemic vasculature. These findings demonstrate that direct vascular actions of AT1A receptors play a prominent role in BP control and hypertension pathogenesis in female mice.
Diagnostic dilemmas of mechanical restriction of the medial rectus: A case report:

BackgroundDue to the proximity of the maxillary sinus and ethmoid sinuses to the orbit, inflammatory processes that originate in the sinonasal region have the potential to extend into the orbit.Obj...
Inhibition of JH I Synthesis In Vitro by a Cerebral Allatostatic Neuropeptide in Manduca Sexta

Regulation of juvenile hormone (JH) synthesis by the corpora allata (CA) is a complex process integrating both stimulatory and inhibitory mechanisms to achieve developmentally precise changes in gland activity. These changes in turn contribute to the fluctuations in the JH hemolymph titer which govern post-embryonic development. Recent evidence indicates that stimulation of the CA is effected in some systems by neuropeptides termed allatotropins, and inhibition of the CA by allatostatic factors has also been suggested (Tobe and Stay, 1985). However, comparatively little is known of the nature of these moieties.
Undergraduate consultation: opportunities and challenges

In this paper, a required Undergraduate Consultation course is described and evaluated. The junior and senior level students who enroll in the course are used as assistants in both closed and open labs for first-year and second-year computer science courses. Whether the course should be required or even offered at all has generated quite a bit of spirited debate, both locally and externally. In order to evaluate the course in a fair and balanced manner, many different constituents were surveyed: students enrolled in the course (hereafter referred to as consultants), students being helped by the consultants, the teaching assistants who oversee the laboratories, the instructors who oversee the consultants, and external computer science educators. The course is described in detail in section one. In sections two through five, feedback regarding the course is presented. Finally, section six synthesizes the findings and makes some recommendations regarding the course.
Description of a novel co-curricular professional engagement program for student pharmacists.

Abstract Introduction Development of professionalism is essential for student pharmacists. This paper describes the development of a novel co-curricular professional engagement program for student pharmacists. Methods At admission, all student pharmacists are enrolled in a faculty-developed professional engagement program. The program was designed to address various key elements of Standards 3 and 4 of the Accreditation Council for Pharmacy Education Accreditation Standards. The program requires student pharmacists to complete a variety of required and electives activities each professional year. Student progression and completion of these activities is monitored and evaluated by an assigned faculty member. Each year, the program is reviewed using various measures, including activity completion rate and student feedback. Results Approximately 1000 student pharmacists, across four years and seven cohorts of students, have completed at least one portion of the program. All students in the aforementioned groups completed the program in its entirety. Example activities included professional seminars and professional organization involvement, leadership, and community service. Program activities were mapped to key elements of Standards 1 through 4 with an emphasis on Standards 3 and 4. Student feedback was used for continuous quality improvement, and programmatic revisions were made. Conclusions The development and implementation of a co-curricular professional engagement program offered the opportunity for student pharmacists to actively participate in a variety of experiences supporting accreditation standards. Other colleges of pharmacy may benefit from the adoption of a similar program to support student pharmacist professional development.
Batched Neural Bandits.

In many sequential decision-making problems, the individuals are split into several batches and the decision-maker is only allowed to change her policy at the end of batches. These batch problems have a large number of applications, ranging from clinical trials to crowdsourcing. Motivated by this, we study the stochastic contextual bandit problem for general reward distributions under the batched setting. We propose the BatchNeuralUCB algorithm which combines neural networks with optimism to address the exploration-exploitation tradeoff while keeping the total number of batches limited. We study BatchNeuralUCB under both fixed and adaptive batch size settings and prove that it achieves the same regret as the fully sequential version while reducing the number of policy updates considerably. We confirm our theoretical results via simulations on both synthetic and real-world datasets.
Teachable Agent as an Interactive Tool for Cognitive Task Analysis: A Case Study for Authoring an Expert Model

This paper demonstrates that a teachable agent (TA) can play a dual role in an online learning environment (OLE) for learning by teaching—the teachable agent working as a synthetic peer for students to learn by teaching and as an interactive tool for cognitive task analysis when authoring an OLE for learning by teaching. We have developed an OLE (called APLUS) on which students can interactively teach a TA (called SimStudent) how to solve problems. APLUS has a cognitive tutor embedded (aka meta-tutor) that provides students with adaptive feedback and help on how to solve problems. The results showed that the expert model created by SimStudent was highly accurate with more than 0.95 precision and recall scores on two different task domains (equation solving and fraction addition). The cost analysis showed that although the authors need to provide SimStudent with task dependent Java code, the amount of code written was relatively small—about 1000–2000 lines of code in 20 to 50 classes. Those findings imply that the TA has practical potential to help authors of APLUS create a domain expert model for the embedded cognitive tutor and the tutoring interface used for the OLE. It was also observed that the failure of TA to learn expected cognitive skills helps the author identify missing essential cognitive factors that must be encoded in the OLE.
Optimization Technique to Support Integrated Generation Units in the Iraqi Super Grid 400kV for Performance Improving

This research aims to study the effects of adding large scale Generation Units at optimal size and site to mitigate the congestion lines, reduce the power losses, and improve the voltage profile for the Iraqi national grid system400kV. The proposed Genetic Algorithm is implemented to determine the optimum size and location based on a multi objective function that depends on the voltage, active losses, and congestion lines as fitness. The results show the proposed approach for determining the optimum size and location, which alleviated the congestion line, reduced power losses, reduced line flow, and improved the bus voltage profile. The results are obtained with proposed algorithm implementation by using programming language within MATLAB /R2018a environment.
Contrast-enhanced magnetic resonance imaging confirmation of an anterior protein pathway in normal rabbit eyes.

Purpose. Contrast-enhanced proton magnetic resonance imaging ('H MRI) has been used as a quantitative, noninvasive method to corroborate a pathway for the diffusion of plasma-derived protein into the aqueous humor in the normal rabbit eye. Methods. T1-weighted magnetic resonance images were produced over 1- to 3-hour periods after the intravenous injection of gadolinium diethylenetriamine-pentaacetic acid. Results. Analysis of the images yielded the time dependence of signal enhancements within the areas of interest. The ciliary body showed an immediate sharp increase, followed by a gradual decrease in signal enhancement with time. Although a gradual increase in signal enhancement was found in the anterior chamber, no significant change occurred in the posterior chamber. A similar MRI experiment with an owl monkey produced parallel, though smaller, signal enhancements in the ciliary body and anterior chamber. Again, however, no significant change was found in the posterior chamber. Conclusions. These results support and extend those of recent fluorophotometric, tracer-localization, and modeling studies demonstrating that in the normal rabbit and monkey eye, plasma-derived proteins bypass the posterior chamber, entering the anterior chamber directly via the iris root.
Piezoelectric Devices in Biomedical Applications

We focus on piezoelectric devices in biomedical applications only. The devices are classified depending on their electrical, mechanical, or hybrid output signal. The hybrid device operates in a reversible mode and can generate both electrical and mechanical signals at its terminals. Electrical output piezoelectric sensors include frequency generators, force and pressure measurement sensors, accelerometers, velocity and displacement sensors, and receivers such as microphones. Linear scanning motors and acoustic wave generators fall into the category of mechanical output devices or actuators. Also, acoustic wave generators, such as lithotripters, loudspeakers, and ultrasonic therapy applicators, can be considered as actuators. Medical ultrasonic transducers used to generate images of internal organs of the body can be defined as hybrid or combination devices, as they act as both actuators and receivers producing an electrical signal proportional to the input mechanical stimulus at their terminals, and conversely, a mechanical displacement amplitude proportional to the electrical excitation. Keywords: piezoelectricity; ferroelectric; transducers; scanning; actuators; receivers; ultrasonics
Ultrasonic evaluation of mechanical properties of thick, multilayered, filament wound composites

A preliminary investigation is conducted to define capabilities and limitations of ultrasonic and acousto-ultrasonic measurements related to mechanical properties of filament wound graphite/epoxy composite structures. The structures studied are segments of filament wound cylinders formed of multiple layers of hoop and helical windings. The segments consist of 24 to 35 layers and range from 3.02 to 3.34 cm in wall thickness. The resultant structures are anisotropic, heterogeneous, porous, and highly attenuating to ultrasonic frequencies greater than 1 MHz. The segments represent structures to be used for space shuttle booster cases. Ultrasonic velocity and acousto-ultrasonic stress wave factor measurement approaches are discussed. Correlations among velocity, density, and porosity, and between the acousto-ultrasonic stress wave factor and interlaminar shear strength are presented.
Implementation of screening, brief intervention, and referral to treatment (SBIRT) in the emergency department without additional resources

Patients who misuse substances present in inordinate numbers for emergency department (ED) services. Therefore, EDs are an important environment for identifying, intervening and connecting patients with treatment and recovery support to improve patient health and reduce healthcare utilization. EDs have largely depended on external funding or additional personnel to execute SBIRT. Our aim was to integrate SBIRT into the ED workflow and coordinate transfer to treatment and community support programs without added monetary/staff resources. Beginning in 2010, we worked cooperatively with a local ED to integrate SBIRT into the normal ED workflow. This program of screening, brief interventions and warm-handoff referral is dubbed “Safe Landing.” Efforts have focused on: training staff; embedding SBIRT tools into existing data systems; nurturing relationships with community treatment and recovery providers; developing protocols for a “warm-handoff” that would ensure patients who, in the context of a health crisis, express an immediate interest in following a road to recovery; and securing reimbursement for services. Over one-and-a-half years since implementation, 45,770 patients have been screened, with 7,996 assessed, 2,058 receiving a brief intervention, and 137 referred to treatment or recovery support. Multiple staff trainings have resulted in a palpable culture shift to patient advocacy and increasing compliance with SBIRT protocols. Screening and BI tracking tools embedded in the ED data systems continue to be enhanced. ED reimbursement for SBIRT began 10/2012, and cooperative relationships with treatment and recovery providers have diversified. We will discuss the implementation strategies employed to overcome challenges in operationalizing SBIRT in the ED. Challenges to be discussed include changes in key personnel, embedding SBIRT into the labyrinth of data systems, initial staff scepticism and evolving area treatment and recovery services organizations. Regardless, Safe Landing perseveres, and commitment by the local ED is stronger than ever.
Thyroid hormones regulate G-protein beta-subunit mRNA expression in vivo.

Abstract Thyroid hormones exert "permissive effects" on the hormone-sensitive adenylate cyclase. Regulation of the expression of Gi (Gi alpha 2) and Gs by thyroid hormones in vivo was investigated at the level of mRNA. Steady-state levels of the mRNA for Gi alpha 2 and Gs alpha, as well as the G beta-subunits, were quantified using DNA excess solution hybridization analysis. Regulation of protein and mRNA expression in adipose tissue was investigated in hypothyroid, euthyroid, and hyperthyroid rats. In euthyroid animals, steady-state levels of mRNA (amol/microgram RNA) were 13.8, 5.9, and 5.7 for Gs alpha, Gi alpha 2, and G beta 1,2, respectively. Activation of adenylate cyclase by Gs is unaffected by thyroid status. Both Gs alpha and Gs alpha mRNA levels in hypothyroid rats were the same as those of controls (euthyroid). The inhibitory control of adenylate cyclase, in contrast, is markedly potentiated in hypothyroid rats. The expression of G1 alpha s and G beta-subunits was increased in hypothyroidism. Whereas Gi alpha 2 mRNA levels remained essentially unchanged, G beta 1,2 mRNA levels were observed to increase 45% in the hypothyroid state. In the hyperthyroid state G beta 1,2 mRNA levels were observed to decline by 35%. Regulation of G-protein subunit expression, at the level of mRNA, appears to be one component of permissive hormone action on transmembrane signalling.
Why Assertion and Practical Reasoning Must be Governed By the Same Epistemic Norm

I argue that assertion and practical reasoning must be governed by the same epistemic norm. This is because the epistemic rule governing assertion derives from the epistemic rule governing practical reasoning, together with a plausible rule regarding assertion, according to which assertion must manifest belief.
Muscimol-Induced Inactivation of Monkey Frontal Eye Field: Effects on Visually and Memory-Guided Saccades

Muscimol-induced inactivation of the monkey frontal eye field: effects on visually and memory-guided saccades. Although neurophysiological, anatomic, and imaging evidence suggest that the frontal e...
One loop predictions of the finely tuned supersymmetric standard model

We study the finely tuned supersymmetric standard model, recently proposed by Arkani-Hamed and Dimopoulos, at the one loop level. The runnings of the four gaugino Yukawa couplings, the $\ensuremath{\mu}$ term, the gaugino masses, and the Higgs quartic coupling are computed. The Higgs mass is found to be 130--170 GeV for ${M}_{s}g{10}^{6}\text{ }\text{ }\mathrm{G}\mathrm{e}\mathrm{V}$. Measuring the Yukawa coupling constants at the 10% level can begin to constrain the supersymmetry breaking scale. Measuring the relationships between the couplings will provide a striking signal for this model.
Trajectory Following Methods in Control System Design

A trajectory following method for solving optimization problems is based on the idea of solving ordinary differential equations whose equilibrium solutions satisfy the necessary conditions for a minimum. The method is `trajectory following' in the sense that an initial guess for the solution is moved along a trajectory generated by the differential equations to a solution point. With the advent of fast computers and efficient integration solvers, this relatively old idea is now an attractive alternative to traditional optimization methods. One area in control theory that the trajectory following method is particularly useful is in the design of Lyapunov optimizing feedback controls. Such a controller is one in which the control at each instant in time either minimizes the `steepest decent' or `quickest decent' as determined from the system dynamics and an appropriate (Lyapunov- like) decent function. The method is particularly appealing in that it allows the Lyapunov control system design method to be used `on-line'. That is, the controller is part of a normal feedback loop with no off-line calculations required. This approach eliminates the need to solve two-point boundary value problems associated with classical optimal control approaches. We demonstrate the method with two examples. The first example is a nonlinear system with no constraints on the control and the second example is a linear system subject to bounded control.
Prophylactic bilateral radical mastectomy resulting from factitious disorder.

Received March 30, 2001; revised July 16, 2001; accepted July 20, 2001. From the Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL. Address correspondence and reprint requests to Dr. Feldman, Center for Psychiatric Medicine, 1713 Sixth Avenue South, UAB Station, Birmingham, AL 35294-0018. Copyright 2001 The Academy of Psychosomatic Medicine. As awareness of hereditary cancers grows, individuals who may be at risk on the basis of a family history are pursuing risk determination and, as appropriate, prophylactic medical or surgical intervention. Through news outlets and health-related Internet Web sites, the public is increasingly aware of the importance of genetic transmission and the possibilities of attenuating heritable risk factors. One point emphasized is that heritable cancers tend to arise in several close relatives and in multiple generations within the same family. Considering that the expression of factitious disorders is limited only by an individual’s creativity andmotivation, it is perhaps not surprising that alarming genetic histories would be invoked by some individuals who seek the intangible benefits of the “sick role.” Unlike individuals who malinger for external benefits such as money or abusable medications, patients with factitious disorder deliberately produce or falsify illness to secure the attention, sympathy, nurturance, and lenience of others. They may also manufacture illness to manipulate and control others, to enhance their own self-esteem through association with medical professionals, and to organize and preserve their sense of identity. This case report discusses a woman who chose to present herself as a member of a family ravaged by a history of cancer. Like many individuals with factitious disorders, she obtained unnecessary surgical intervention, this time in the dramatic form of a prophylactic bilateral radicalmastectomy. She meets criteria for the diagnosis of factitious disorder in that she engaged in a pattern of deliberately misleading health professionals about her background while lacking any evident motivation beyond assuming the mantle of “patienthood.” Searches of MEDLINE (1966 to present), CancerLit (1975 to present), HealthSTAR (1975 to present), and ISI Science Citation (1995 to present) computer databases failed to uncover any previously published reports of prophylactic radical mastectomy prompted by a false family history. However, one case of prophylactic subcutaneous mastectomy based on a spurious family history has been reported.
Partial purification of the activated hepatic glucocorticoid - receptor complex.

Abstract A rapid procedure for the purification of the hepatic glucocorticoid receptor has been developed which exploits the observation that ‘activation’ of this complexenables it to bind to anionic substances such as DNA and phosphocellulose. The procedure consists of two phosphocellulose columns operated in sequence. The first column removes from unfractionated cytosol all basic proteins which adhere to the immobilized phosphate residues; the steroid-receptor complex elutes in the flow-through of this first column. This complex is then thermally activated and applied to a second phosphocellulose column where it is retained, washed, and eluted by a salt gradient. This simple procedure is capable of purifying the steroid-receptor complex over 1000-fold.
LCG Generator Services

In the framework of the Grid Computing at the LHC (LCG), the Generator Services activity, launched in 2003 under the oversight of the LHC Monte Carlo steering group (MC4LHC). The goal of the Generator Services project is to guarantee the physics generator support to the LHC experiments. Work is divided in four work packages. The current status and the future plans in the four different work packages are presented. Some emphasis is put on the LCG Generator Library and on the support to the development and upgrade of object oriented Monte Carlo models.
Travels with Feminist Historical Geography

We explore in this essay the relatively uneven "travels" of feminist historical geography within the academy in order to highlight the realized and potential intellectual productivity that can result from bringing together a feminist and historical approach to understanding place and space. We outline in what ways much of feminist geography is already historical and in what ways much of historical geography is already feminist, and then turn to a discussion of the unevenness of these intellectual journeys. We conclude by suggesting challenges for future research in feminist historical geography.
Silicon layer transfer using wafer bonding and debonding

Two experiments were performed that demonstrate an extension of the ion-cut layer transfer technique where a polymer is used for planarization and bonding. In the first experiment hydrogen-implanted silicon wafers were deposited with two to four microns low-temperature plasma-enhanced tetraethoxysilane (TEOS). The wafers were then bonded to a second wafer, which had been coated with a spin-on polymer. The bonded pairs were heated to the ion-cut temperature resulting in the transfer of a 400 nm layer silicon. The polymer enabled the bonding of an unprocessed silicon wafer to the as-deposited TEOS with a microsurface roughness larger than 10 nm, while the TEOS provided sufficient stiffness for ion cut. In the second experiment, an intermediate transfer wafer was patterned and vias were etched through the wafer using a 25% tetramethylammonium hydroxide (TMAH) solution and nitride as masking material. The nitride was then stripped using dilute hydrofluoric acid (HF). The transfer wafer was then bonded to an oxidized (100 nm) hydrogen-implanted silicon wafer. After ion-cut annealing a silicon-on-insulator (SOI) wafer was produced on the transfer wafer. The thin silicon layer of the SOI structure was then bonded to a third wafer using a spin-on polymer as the bonding material. The sacrificial oxide layer was then etched away in HF, freeing the thin silicon from the transfer wafer. The result produced a thin silicon-on-polymer structure bonded to the third wafer. These results demonstrate the feasibility of transferring a silicon layer from a wafer to a second intermediate “transfer” or “universal” reusable substrate. The second transfer step allows the thin silicon layer to be subsequently bonded to a potential third device wafer followed by debonding of the transfer wafer creating stacked three-dimensional structures.
FIELD NOTES: MOVING AWAY FROM TRADITION: EXPLORING THE FIELD EXPERIENCES OF PART-TIME, OLDER, AND EMPLOYMENT-BASED STUDENTS

Little is known about field placement experiences of growing subgroups of students, particularly older, part-time, and field employment–based. Because of the centrality of field placements within MSW education, these student subgroups in field placements at one northeastern school were surveyed (N=779). A MANOVA analysis examined students' experiences with field setting, field supervision, and faculty field liaison. Results revealed that part-time, employment-based, or advanced-year students were significantly more positive about field experiences than full-time, non-employment–based, or foundation-year students. Age was not a significant factor. Implications of findings for admissions decisions, teaching, and structure of field education programs are discussed.
Assessing the condition of children

Abstract Proposed child welfare legislation challenges states to initiate new programs to help children who have been neglected, abused, or abandoned by their parents. This paper describes ways to appraise the condition of children and the functioning of families in order to evaluate the effects of child welfare reform efforts. The assessment approach grows out of a “whole child” perspective, encompassing physical health, cognitive development, emotional well-being, and moral development and social behavior. Specific measures to assess these aspects of child development are described, most of which have shown meaningful differences between groups in large-scale studies. However, child welfare situations present special challenges: the difficulty of reliably assessing the developmental status of young children; applicability of measures to low-income and minority children and very dysfunctional families; and the problem of obtaining accurate, unbiased information from parents. Several research strategies are proposed to combat these difficulties. One promising development for the future of child welfare evaluations is that a number of these strategies have been incorporated into large-scale, longitudinal evaluation studies of welfare-to-work, child care, and integrated service delivery programs.
Synthesis of the New Ternary Transition Metal Nitride FeWN2 via Ammonolysis of a Solid State Oxide Precursor

A new ternary nitride, FeWN[sub 2], was prepared via ammonolysis of the solid state oxide precursor FeWO[sub 4] at 800[degrees]C. The powder diffraction data were indexed as a hexagonal structure with lattice parameters a = 2.867(2) [angstrom] and c = 16.458(9) [angstrom]. The successful preparation of FeWN[sub 2] demonstrates that the inductive effect is not necessary for preparing some ternary transition metal nitrides. 13 refs., 1 fig., 1 tab.
Effects of Ni, Pd, and Pt Substitutions on Thermoelectric Properties of CoSi Alloys

Ni-, Pd-, and Pt-substituted CoSi samples have been prepared by an arc melting and annealing procedure. The x-ray diffraction and scanning electron microscopy results show that Ni and Pd are effective n-type dopants for CoSi, while Pt is immiscible with CoSi and forms an impurity phase with a possible chemical formula of PtCoSi2. The thermoelectric properties were measured from 80 K to 300 K. For Ni- and Pd-doped samples, the electrical resistivity and Seebeck coefficient decrease simultaneously due to the increasing carrier concentration. For Pt-substituted samples, the electrical resistivity also decreases. However, this reduction is thought to be not due to an increase in carriers but rather to originate from the effect of the Pt-rich impurity phase at the grain boundaries. The Seebeck coefficient is not affected by 1% Pt substitution; however, further increase of the Pt level also causes a decrease in the Seebeck coefficient. The room-temperature power factor is 63 μW K−2 cm−1 for pure CoSi and 73 μW K−2 cm−1 for the Co0.99Pt0.01Si sample. Although the thermal conductivity is reduced for both n-type-doped and Pt-substituted samples around 80 K, the room-temperature values are still close to that of pure CoSi. As a result, ZT of 0.13 is obtained at room temperature for Co0.99Pt0.01Si, an 18% increase compared with CoSi.
Long time regularity of solutions of the Hele–Shaw problem

Abstract In this paper we study the long-time behavior of solutions of the one phase Hele–Shaw problem without surface tension. We show that after a finite time solutions of the Hele–Shaw problem become starshaped and Lipschitz continuous in space. Based on this observation we then prove that the free boundary become smooth in space and time with nondegenerate free boundary speed.