cssi/SciSciGPT-SciSciNet huggingface dataset:
Regulation of prostaglandin endoperoxide synthase gene expression in cultured rat mesangial cells: induction by serum via a protein kinase-C-dependent mechanism.

Recent evidence suggests that the steady state level of prostaglandin (PG) endoperoxide synthase (PES) might regulate long term increases in PG synthesis, but the mechanism(s) regulating PES gene expression remains unclear. The present experiments investigated the regulation of PES expression in quiescent mesangial cells treated with serum. Serum induced time-dependent increases in PES steady state mRNA, protein level, and enzyme activity. Both the kinetics and cycloheximide sensitivity of PES mRNA induction suggest that PES was induced as a member of the delayed-early gene set. Beta-adrenergic-mediated cAMP accumulation was similar in G° and cycling cells, suggesting that the increase in PES expression did not reflect global upregulation of signaling cascades in serum-treated cells. Three lines of evidence suggest that protein kinase-C (PKC) mediates serum-stimulated PES gene expression: 1) 12-tetradecanoyl phorbol 13-acetate mimicked the serum response; 2) PES gene expression by serum was attenuated in ...
Stew of Discontent: “Middle Class” Americans' Economic Populism in the 1990s and Beyond

This article highlights the hidden subtlety of ordinary Americans' economic populist sentiment, a longstanding and politically pivotal form of popular resentment concerning class inequalities. Based on my research in the late 1990s, I describe how economic populist attitudes in the United States can be much more complex than suggested in the relevant literature. I use data from interviews with a small number of “ordinary middle class” Americans to illustrate little known nuances in these attitudes and to highlight how such subtleties are overlooked in prevailing characterizations of public opinion. I suggest that the oversight is the result of the fragmentary nature of the study of U.S. class consciousness. I call for critical reflection on underlying biases that may obstruct a more integrated approach, and I explain how a more holistic perspective on economic populist attitudes may be used to mobilize subordinate class discontent in the United States more effectively.
VLSI neural systems and circuits

ULSI technology can potentially fabricate 10/sup 9/ devices on a single die. Numerous applications in the areas of vision, speech, sensor processing, nonlinear control, and learning exist for such integrated circuits, but first new fault-tolerant architectures need to be developed. One approach is to design systems that are inspired by the human brain. These architectures operate in a highly parallel fashion to solve extremely complex problems with a high degree of fault tolerance. A description is given of the pulsed neural cell, which is a compact analog neural circuit. The pulsed neural cell performs four-quadrant multiplication, refreshes the stored analog voltages, and allows linear and nonlinear outputs. This cell allows the building of massive and highly complex neural implementations. >
Social Ontology and the Dynamics of Organizational Forms: Creating Market Actors in the Healthcare Field, 1966–1994

Social scientists have evidenced a long-standing interest in the cultural construction of ontologies - symbolic systems of categorization and meaning- but have yet to develop a widely recognized methodfor the empirical analysis of this process. Analyzing textual datafrom the area of health services research, this article illustrates a generalframework that can be employed to isolate the tacit rules used to structure an ontology and identifr changes in those rules over time. Focusing on the process of market reform in U.S. healthcare during the last thirty years, this study finds systematic variation in the dimensions used to differentiate discourse on organizationalforms such as hospitals, health maintenance organizations, and nursing homes. Discourse in the sector suggests that the symbolic integration offorms along the dimension of accessibility during the heyday of welfare state policies has given way to symbolic integration along clinical andfunctional dimensions with the rise of neoliberal ideologies. These segregating and blendingprocesses are discussed as a general response to uncertainty and the desirefor ontological security among organizational actors.
Use of four-dimensional ground penetrating radar and advanced visualization methods to determine subsurface fluid migration

Four-dimensional (4D) or time-lapse three-dimensional (3D) ground penetrating radar surveys can be used to monitor and image subsurface fluid flow. This information can be used to create a model of hydrogeological properties. The massive amount of data, which is present in and can possibly be generated from 4D GPR data sets, precludes a manual interpretation. Consequently, 4D data sets have to be processed and visualized in a way that extracts models and allows for data visualization in a semi-automatic way. The principles behind such an approach are applied to the Borden data set, which is used to demonstrate how advanced visualization can assist in the interpretation of raw and processed data. In the Borden data set, changes in reflectivity between different time-steps unveil areas of fluid migration in three dimensions. The combination of these reflectivity changes (between different combinations of the 3D subsets of the 4D data set) is used to create a model of hydrogeological properties. While this model does not yield a quantitative description of porosity, permeability or hydraulic conductivity, it is a qualitative proxy for a combination of these properties.
Extending Research on the Utility of an Adjunctive Emotion Regulation Group Therapy for Deliberate Self-Harm Among Women With Borderline Personality Pathology

Deliberate self-harm (DSH) is a clinically important behavior commonly associated with borderline personality disorder (BPD). Despite the clinical relevance and associated negative consequences of this behavior, however, there are few empirically supported treatments for DSH among individuals with BPD, and those that exist are difficult to implement in many clinical settings (due to their duration and intensity). To address this limitation, Gratz and Gunderson (2006) examined the efficacy of a 14-week, adjunctive emotion regulation group therapy (ERGT) for DSH among women with BPD. Although the results of this initial trial were promising (indicating positive effects of this treatment on DSH, emotion dysregulation, experiential avoidance, and psychiatric symptoms), they require replication and extension. Thus, the purpose of this study was to further develop this ERGT by examining its utility across other settings, a more diverse group of patients, a wider range of outcomes, and group leaders other than the principal investigator. Twenty-three women received this ERGT in addition to their ongoing treatment in the community. Self-report and interview-based measures of DSH and other self-destructive behaviors, psychiatric symptoms, adaptive functioning (including social and vocational impairment and quality of life), and the proposed mechanisms of change (emotion dysregulation and experiential avoidance) were administered pre- and posttreatment. Results indicate significant changes over time (accompanied by large effect sizes) on all outcome measures except quality of life and self-destructive behaviors (although the latter was a large-sized effect). Further, 55% of participants reported abstinence from DSH during the last two months of the group.
Implicit ordering of defaults in inheritance systems

There is a natural partial ordering of defaults in inheritance systems that resolves ambiguities in an intuitive way. This is not the shortest-path ordering used by most existing inheritance reasoners. The flaws of the shortest-path ordering become apparent when we consider multiple inheritance. We define the correct partial ordering to use in inheritance and show how it applies to semantic network systems. Use of this ordering also simplifies the representation of inheritance in default logic.
Performance study of the subreflector for a dual chamber compact range design

In order to study the performance of the Gregorian subreflector and the small chamber of a dual-chamber compact range, a diagnostic technique which processes the complex far zone antenna pattern data to find the various radiation centers is used to determine the location of stray signals. By applying this technique to the patterns of the subreflector enclosed in the small chamber, the cross range location of desired and stray signals of the system can be determined. Consequently adjustments of the system can be made, such as placement of an absorber used to reduce the stray signal strength and improve the performance of the system. Experimental results of the system with different setups at 10 GHz are shown. >
Multiple Access Channels with Generalized Feedback and Confidential Messages

This paper considers the problem of secret communication over a multiple access channel with generalized feedback. Two trusted users send independent confidential messages to an intended receiver, in the presence of a passive eavesdropper. In this setting, an active cooperation between two trusted users is enabled through using channel feedback in order to improve the communication efficiency. Based on rate- splitting and decode-and-forward strategies, achievable secrecy rate regions are derived for both discrete memoryless and Gaussian channels. Results show that channel feedback improves the achievable secrecy rates.
Map-aided GPS/INS localization using a low-order constrained Unscented Kalman Filter

This paper presents a map-aided GPS/INS localization system developed for a map-based driver safety assistance system. A low-order constrained Unscented Kalman Filter (CUKF) is adopted to fuse the GPS, INS and high-accuracy map data to provide robust lane-level vehicle position and heading estimates for time-critical safety applications. The road data from digital map is formulated as state constraints including the heading and lateral in-lane/road position constraints. Compared to the other nonlinear state estimation approaches with or without constraints, such as the Particle Filter (PF), Moving Horizon Estimation (MHE) and Extended Kalman Filter (EKF), the proposed low-order constrained Unscented Kalman Filter has the merits of improved computational tractability, higher accuracy, ease of implementation and better state constraint handling capability. Testing results using real sensor data are compared with a previously developed EKF-based GPS/INS positioning system to demonstrate the effectiveness of the new CUKF approach.
‘Bodies is what makes it work’: Statecraft and urban informality in the Philadelphia recovery house movement

There are some 30,000 abandoned row houses in the city of Philadelphia. In the neighborhood of Kensington, recovery house operators have reconfigured hundreds of row homes to produce the Philadelphia recovery house movement: an extra-legal poverty survival strategy for addicts and alcoholics located in the city’s poorest and most heavily blighted zones. The purpose of this article is to explore, ethnographically, the ways in which street-level survival mechanisms articulate with the restructuring of the contemporary welfare state and the broader political economy of Philadelphia. I use ethnographic data to reveal how the recovery house, as an unplanned predatory ‘subsistence niche’ (Davis, 2006), operates in concert with the workfare state, the informal/deregulated low wage service sector, and the criminal justice system. The contradictions of the movement explain how informal street level poverty politics in areas of spatially concentrated poverty work along the periphery of post-welfare regulatory insti...
Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms

Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. The laboratory studies conducted in animal models suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.
Maternal Sensory Sensitivity, Mother-Infant 9-Month Interaction, Infant Attachment Status: Predictors of Mother-Toddler Interaction at 24 Months

At 24-months of age, toddlers (N = 62) and their mothers were observed in a free-play session to determine the contribution of (a) maternal sensory sensitivity to positive and negative infant facial expressions as measured in a signal detection task at 6 months (b) maternal behavior and affect, infant behavior and affect, and dyadic interaction at 9 months, and (c) infant attachment status at 12 months in predicting maternal, toddler, and dyadic measures at 24 months. Hierarchical regression analyses revealed that over and above early maternal behavior, which was predictive of later maternal behavior at 24 months, sensory sensitivity to the positive infant expression at 6 months predicted maternal behavior at 24 months and sensory sensitivity to both the positive and negative expression was associated with later maternal affect. Infant attachment status emerged as the variable which predicted toddler behavior and dyadic interaction at 24 months.
Perceived Breast Development and Adolescent Girls’ Psychological Well-Being

This study, based on U.S. nationally-representative data from the National Longitudinal Study of Adolescent Health (8,593 13–18 year old girls), explored how perceived breast development was related to psychological well-being among adolescent girls including variations by age and race-ethnicity. It was hypothesized that greater breast development would detrimentally influence adolescent girls’ psychological well-being, although these associations were expected to be stronger for younger adolescent girls and for Whites. Results using multivariate regression analyses with robust standard errors showed that greater perceived breast development was associated with lower self-esteem and higher depressive symptoms for 13–15 year old White, African American (for self-esteem only), and Hispanic (for depressive symptoms only) girls. Although perceived breast development was not associated with 16–18 year old girls’ self-esteem, supplemental analyses found that 16–18 year old Asian American and White girls with considerable or little breast development had more depressive symptoms than those with some breast development. Menarche at a younger age, overweight BMI, perceptions of being overweight, and efforts to lose weight explained a substantial portion of these associations. This study shows that greater perceived breast development, particularly if it occurs at a younger age, is a risk factor for poorer psychological well-being among adolescent girls including racial-ethnic minorities.
Competence Versus Performance Models of People and Tests: A Commentary on Richardson and Norgate

Corrections are sometimes applied to correlations between IQ and job performance (or other criteria) in order to determine the true correlation between these two measures. However, there is no one true correlation between IQ and job performance. The level of correlation depends on many factors and varies across time and place. Moreover, IQ tests and job criteria measure different things for different people, depending on the people's cultural and socioeconomic backgrounds. In this commentary, I laud Richardson and Norgate (this issue) for their recognition of the complexities of issues relating IQ to job performance. I further point out that although the tendency of some investigators is to suggest factors that should increase the correlation between IQ and job performance, one just as easily could suggest factors that should decrease the correlation.
Clinical Examination Results in Individuals With Functional Ankle Instability and Ankle-Sprain Copers

Context: Why some individuals with ankle sprains develop functional ankle instability and others do not (ie, copers) is unknown. Current understanding of the clinical profile of copers is limited. Objective: To contrast individuals with functional ankle instability (FAI), copers, and uninjured individuals on both self-reported variables and clinical examination findings. Design: Cross-sectional study. Setting: Sports medicine research laboratory. Patients or Other Participants: Participants consisted of 23 individuals with a history of 1 or more ankle sprains and at least 2 episodes of giving way in the past year (FAI: Cumberland Ankle Instability Tool [CAIT] score = 20.52 ± 2.94, episodes of giving way = 5.8 ± 8.4 per month), 23 individuals with a history of a single ankle sprain and no subsequent episodes of instability (copers: CAIT score = 27.74 ± 1.69), and 23 individuals with no history of ankle sprain and no instability (uninjured: CAIT score = 28.78 ± 1.78). Intervention(s): Self-reported disabili...
A case-based approach to UTI imaging – making sense of the guidelines

Urinary tract infections (UTIs) are common amongst children and invariably result in imaging tests to look for correctable causes that may predispose the child to infection. The objective of imaging is to identify those children at risk of long-term renal damage. The ideal imaging algorithm is extensively debated in the literature owing to the lack of evidence-based data, evolving theories on the pathophysiology of UTI and vesicoureteric reflux (VUR). The present article provides a case-based approach to the imaging of UTIs and proposes guidelines relevant to the South African setting.
Impact of Extent of Resection on Outcomes in Patients with High-Grade Gliomas

Throughout the course of human history, surgical therapy has remained a viable option for the treatment of certain, well-defined lesions. However, particularly given the technological advancements over the last half-century, the fields of neurosurgery and neurooncology have been able to embrace multimodal forms of therapy, including maximal safe surgical resection, radiotherapy, and both local and systemic chemotherapy, in an effort to improve survival and decrease the odds of developing new post-operative deficits in patients with highly malignant gliomas. Some studies do appear to indicate that extent of resection plays a favorable role in survival of patients with high grade gliomas, although the exact relationship between extent of resection and survival or poor outcomes is not completely defined. Future prospective, randomized trials may need to be developed to assess the effect of multimodal forms of imaging, motor mapping, and combination forms of therapy upon short- and long-term patient outcomes.
Innovations in Public Participation and Environmental Planning: Examples from the Great Lakes Region

Public participation has become a standard component of environmental decision-making processes. Frequently used methods of public involvement, such as public comments and hearings, however, are too often reactive in nature, involve insufficient deliberation, and engage only a small number of participants. This article describes a set of "innovative" participatory processes — study circles, citizens juries, round tables, and collaborative watershed management efforts — and considers their relative strengths and weaknesses through the use of a common comparative framework. The analysis shows that these innovative processes offer some different and potentially valuable advantages relative to the public involvement methods commonly used today. While the processes standing alone are not likely to replace traditional methods, preliminary analysis suggests that they may be effective if applied strategically, and in combination with other innovative or traditional processes.
A meshfree method for bending and failure in non-ordinary peridynamic shells

The peridynamic theory of solid mechanics offers an integral based alternative to traditional continuum models based on partial differential equations. This formulation is particularly advantageous when applied to material failure problems that result in discontinuous displacement fields. This paper presents a meshfree implementation of a state-based peridynamic bending model based on the idea of rotational springs between pairs of peridynamic bonds. Energy-based analysis determines the properties of these bond pairs for a brittle material, resulting in a constitutive model that naturally gives rise to localized damage and crack propagation.
Deep signatures for indexing and retrieval in large motion databases

Data-driven motion research requires effective tools to compress, index, retrieve and reconstruct captured motion data. In this paper, we present a novel method to perform these tasks using a deep learning architecture. Our deep autoencoder, a form of artificial neural network, encodes motion segments into "deep signatures". This signature is formed by concatenating signatures for functionally different parts of the body. The deep signature is a highly condensed representation of a motion segment, requiring only 20 bytes, yet still encoding high level motion features. It can be used to produce a very compact representation of a motion database that can be effectively used for motion indexing and retrieval, with a very small memory footprint. Database searches are reduced to low cost binary comparisons of signatures. Motion reconstruction is achieved by fixing a "deep signature" that is missing a section using Gibbs Sampling. We tested both manually and automatically segmented motion databases and our experiments show that extracting the deep signature is fast and scales well with large databases. Given a query motion, similar motion segments can be retrieved at interactive speed with excellent match quality.
Abstract B54: SR-B1 directed nanoparticles in targeted therapy for the treatment of metastatic triple-negative breast cancer

This study endeavors to fill a void in the treatment of metastatic triple negative breast cancer (TNBC) with the use of scavenger receptor class B type 1 (SR-B1) targeted reconstituted high-density lipoprotein (rHDL) nanoparticles. Though new therapies are being evaluated in clinical trials, TNBC remains an incurable disease. Accordingly, the 5-year survival rate for women with metastatic TNBC is less than 30%. The overall goal of this study is to evaluate the efficacy of Lapatinib (an EGFR inhibitor) and Valrubicin (a topoisomerase II inhibitor) encapsulated rHDL nanoparticles in the treatment of metastatic TNBC. Selective uptake of anticancer agents delivered by rHDL nanoparticles via the SR-B1 is being evaluated using H3 cholesterol ester labeled rHDL nanoparticles in the presence and absence of a chemical inhibitor of SR-B1. Anti-proliferative effects of Lapatinib and Valrubicin encapsulated nanoparticles were evaluated using CCK-8 kits. The findings from these studies revealed that the rHDL encapsulated forms of Lapatinib and Valrubicin had enhanced efficacy when used in combination than the free drugs. In particular, rHDL encapsulated Lapatinib had a 55% increase in efficacy in MDA-MB-231 cell line over the un-encapsulated form as a single agent. The ultimate goal of these studies is to assess the impact of rHDL encapsulated Lapatinib and Valrubicin, alone or in combination against TNBC. One of the major barriers to successful cancer chemotherapy is the development of multidrug resistance (MDR) by malignant tumors. rHDL nanoparticles provide a cytosolic drug delivery mechanism for malignant cells and will likely help to overcome drug resistance by TNBC tumors. In addition, the tumor selective delivery of the drug payload via the rHDL nanoparticles is anticipated to reduce or eliminate off target toxicity to normal tissues upon clinical application. Citation Format: Rebecca Johnson, Andras Lacko. SR-B1 directed nanoparticles in targeted therapy for the treatment of metastatic triple-negative breast cancer. [abstract]. In: Proceedings of the Seventh AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 9-12, 2014; San Antonio, TX. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2015;24(10 Suppl):Abstract nr B54.
Testing of Chemical and Microbial Insecticides for Safety … Some Techniques

As the use of various insect control agents increases, the need to study and describe their effects on man and other components of our ecosystem becomes more important. Two different types of suppression agents are being proposed for the Douglas-fir tussock moth: microbial insecticides and chemical insecticides. Although the 2 types of insecticides differ in origin and mode of action, the protocols covering tests of their safety are similar. One major difference is the toxicity-pathogenicity of microbials (Ignoffo 1973).
Charge Flow and d Compensation in Gold Alloys

Measurements were made by x-ray photoelectron spectroscopy of the $4f$ level energies in Au and the $3d$ level energies in Ag with these elements in several forms: pure metals, Au-Ag alloys, Au${\mathrm{Al}}_{2}$, and Au${\mathrm{Ga}}_{2}$. Only very small core-level energy shifts are seen, even though existing M\"ossbauer isomer-shift data for Au show that there are differences in $s$ charge at Au sites such that one would anticipate substantial level shifts. These two sets of observations are interpreted within the framework of band theory to mean that when Au is alloyed with Ag, Al, or Ga, the flow of $s$ charge onto Au sites is accompanied by a compensating depletion of $d$ charge. The problems associated with relating chemical shifts in alloys to charge flow are considered in some detail. It is concluded that the ratio of $d$ depletion to conduction electron gain is 0.6 \ifmmode\pm\else\textpm\fi{} 0.2 in the case of ${\mathrm{Au}}_{0.5}$ ${\mathrm{Ag}}_{0.5}$, and similar behavior is encountered in other Au alloys.
The Significance of Zygospore Character in Polyphagus Euglenae

(1945). The Significance of Zygospore Character in Polyphagus Euglenae. Mycologia: Vol. 37, No. 5, pp. 553-570.
The effect of nitrogen source on levels of amino acids in peas

When nitrogen fixation in peas was partially replaced by nitrate assimilation as the source of nitrogen, an increase was found in the amount of soluble nitrogen that could be extracted from the fruits of the plants, and within this soluble fraction, increases were found in the levels of some of the acidic amino acids. Levels of protein amino acids in the peas were generally unaffected by the type of nitrogen source except for the level of aspartic acid which was about 20 per cent lower in peas supplied with nitrate. No differences were found in the proportions of the essential amino acids.
Application Research of Simulation Technology of Shipborne Combat System

This paper summarizes new technologies of simulation system, and introduces their application in shipborne combat system of our country and foreign countries. It analysis the development state of our military simulation technology and its major differences to the foreign countries, and puts forward the development ways of the simulation application for shipborne combat system in future.
Epidemiological investigation on a case of human infection with highly pathogenic avian influenza (H5N1) in Liping Countyof Guizhou province

Objective To investigate a case of human infection with highly pathogenic avian influenza(H5N1), in order to provide the basic measures for the prevention and control of bird flu. Methods Used epidemiological investigation, clinical examination,real-time PCR and serology methods to analyze and diagnose the case. Results The patient with H5N1 was found in Liping County who died due to multiple organ failure. It was said that the patient was certain to contact with diseased or dead poultry. After taking isolation treatment, medical observation, and personal protective measures, epidemic was under the control, and no secondary cases appeared. Conclusion H5N1 case is found in Liping County belonged to an infection one, the source of infection may be related to contact with sick or dead poultry. It is necessary to strengthen the training for the knowledge about human avian influenza and actively search for and monitor the unexplained pneumonia deaths.In order to prevent the disease from recurring, it is also important to collect the information related to the disease from agriculture, forestry, commerce, transportation and other departments.
Entertainment Orientation and Salesperson Relationship Performance

Many sales organizations invest in “relationship-building activities” by allocating a portion of their budget to socially engage current customers and future prospects. In their boundary-spanning role, salespeople are responsible for developing and managing relationships with customer buying centers and internal cross-functional support teams. The purpose of this study is to assess the importance of entertainment in the sales process. Utilizing social exchange theory and relationship marketing as theoretical foundations, we introduce and develop the conceptual entertainment orientation model. We examine the current role of entertainment in developing and managing sales relationships with internal and external customers. The results confirm that relationship-building activities in the form of entertainment are perceived to play an important role in both external sales with customers and internal relationships with co-workers. The results also reveal that entertainment and internal bonding are viewed as positive influences on firm performance. The findings provide an improved understanding of the current role and importance of entertainment by sales professionals.
Structure-guided wavelength tuning in far-red fluorescent proteins

In recent years, protein engineers have succeeded in tuning the excitation spectra of natural fluorescent proteins from green wavelengths into orange and red wavelengths, resulting in the creation of a series of fluorescent proteins with emission in the far-red portions of the optical spectrum. These results have arisen from the synergistic combination of structural knowledge of fluorescent proteins, chemical intuition, and high-throughput screening methods. Here we review structural features found in autocatalytic far-red fluorescent proteins, and discuss how they add to our understanding of the biophysical mechanisms of wavelength tuning in biological chromophores.
Pseudotumor Cerebri Complicating Measles

A novel case of pseudotumor cerebri (PTC) that presented in an 8-year-old girl 3 weeks after measles is reported from Ondokuz Mayis University, Samsun, Turkey.
Hydrogen-bonded polymer nanocomposites containing discrete layers of gold nanoparticles

Abstract The ability to finely control the spatial location and relative concentration of a nanofiller within a polymer nanocomposite is desirable, especially when faced with fillers that are susceptible to aggregation. In the case of gold nanoparticles (AuNPs), spatial organization is of interest as it offers a means to harness optical and electrical properties, but well-defined placement of AuNPs within a polymer matrix is generally challenging because of phase separation. Here, we demonstrate for the first time the spray-assisted layer-by-layer assembly (LbL) of hydrogen-bonding polymer nanocomposites of poly(ethylene oxide) (PEO) and poly(methacrylic acid) (PMAA) containing discrete regions of AuNPs vertically positioned throughout the film structure. Analysis of the internal structure using cross-sectional transmission electron microscopy (TEM) imaging shows that the AuNP regions are clearly separated by “empty” regions of polymer with no drift or aggregation of the Au NPs during or after fabrication. A UV–vis spectroscopy study of the stimuli-responsive properties of the spray-assisted LbL nanocomposites shows the release of AuNPs as induced by elevating the environmental pH above the critical pH at which the PEO and PMAA hydrogen bonds are disrupted. We anticipate that this work enables the spatial organization of other nanofillers in stimuli-responsive hydrogen-bonding nanocomposites by spray-assisted LbL assembly.
Pain sensitivity and aromatase inhibitor (AI)-associated arthralgias (AIAA).

9615 Background: AIAA affect up to half of AI-treated women with early stage breast cancer, and can lead to treatment discontinuation in 20-30%. The etiology is thought to be related to estrogen de...
KEBIJAKAN PENGENTASAN KEMISKINAN BERBASIS PARTICIPATORY POVERTY ASSESSMENT: Kasus Yogyakarta

Salah satu pertanyaan menarik dalam kebijakan Kemiskinan ialah mengapa penurunan kemiskinan yang telah didukung baik oleh kemauan politik pemerintah yang memadai dan dukungan dana yang mencukupi tetapi tidak menghasilkan penurunan angka kemiskinan yang memadai (masih sekitar 11%)? Kemiskinan memang masalah yang komplek. Selain ia tergantung pada keadaan ekonomi makro yang stabil, kemiskinan juga terkait dengan kebijkan mikro mengenai penurunan kemiskinan itu sendiri. Penelitian ini telah dilakukan di Yogyakarta menggunakan metode kualitatif melalui Focus Group Discussion (FGD), wawancara mendalam dengan berbagai pihak terkait masalah pengentasan kemiskinan (para pejabat pemkot, LSM, para tokoh masyarakat, pendamping program, maupun masyarakat penerima bantuan program kemiskinan) di tiga kecamatan kota yang menjadi Proyek Percontohan. Salah satu temuan yang menarik adalah kurang sabar dan ketakutan mengalami kegagalan program kemiskinan di pihak pelaksana (pemerintah) untuk melibatkan warga miskin secara aktif berperan utama dalam program kemiskinan, justru membuat program pengentasan kemiskinan cenderung hanya memenuhi kebutuhan administrative, dan kurang berhasil dalam mengurangi tingkat kemiskinan dalam arti yang sebenarnya (menciptakan masyarakat yang mampu menolong dirinya sendiri, mandiri, mimiliki harga diri dsb). Dalam riset ini terdapat beberapa hal yang menarik. Dalam hal kebijakan publik, Pemerintah Daerah Istimewa Yogyakarta telah menekankan arti pentingnya modal sosial (berupa pendidikan) untuk kanak-anak dari keluarga miskin untuk memasuki sekolah-sekolah favorit (sekolah-sekolah terbaik dan berkualitas) melalui kebijakan quota 20%. Pemkot Yogyakarta menyadarai bahwa kemiskinan menyangkut baik masalah dimensi agregat (ekonomi) mau pun dimensi non agregat (non ekonomi). Singkatnya pelajaran yang menyangkut baik kelemahan maupun kelebihan kebijakan pengentasan kemiskinan di kota pelajar ini sangat menarik untuk diambil. Kata Kunci: Kebijakan, Pengentasan Kemiskinan, Menolong diri sendiri, dimensi agregrat dan non-agregat
Structure-mediated modulation of mRNA abundance by A-to-I editing

RNA editing introduces single nucleotide changes to RNA, thus potentially diversifying gene expression. Recent studies have reported significant changes in RNA editing profiles in disease and development. The functional consequences of these widespread alterations remain elusive because of the unknown function of most RNA editing sites. Here, we carry out a comprehensive analysis of A-to-I editomes in human populations. Surprisingly, we observe highly similar editing profiles across populations despite striking differences in the expression levels of ADAR genes. Striving to explain this discrepancy, we uncover a functional mechanism of A-to-I editing in regulating mRNA abundance. We show that A-to-I editing stabilizes RNA secondary structures and reduces the accessibility of AGO2-miRNA to target sites in mRNAs. The editing-dependent stabilization of mRNAs in turn alters the observed editing levels in the stable RNA repertoire. Our study provides valuable insights into the functional impact of RNA editing in human cells.
The Representation of Agents as Resources for the Purpose of Professional Regulation and Global Health Workforce Planning

International migration of health professionals has been increasing in our globalized world, compounding a pressing need to improve information systems that confirm their qualifications and track health workforce volume. This paper reports on research to help address this need by introducing a framework for defining health professionals as agents. A case study and a categorical analysis of 11 metadata schemes was conducted. The results report and discuss three approaches to the representation of agents as either Access Point, Information Object, or Resource. The schemas that describe agents as resources best align with the representation of health professionals for the purpose of health workforce research.
The Devil in the Details: An Essay on the Blind Watchmaker, the Invisible Hand, and the Theology of Whiteness

This essay explores the puzzle of persistent racial inequality. It probes the well-worn alternatives of racism and merit by raising a provocative comparison between the intelligent design creationism and racial conspiracy theories. In each case, proponents observe complexity and, with deep personal commitments at stake, reason that some kind of agent must be responsible, either a benevolent God or a malevolent racist. In each case, respondents agree about the definition of religion or racism as grounded in an agent of some kind, but argue that ordinary science - either evolutionary biology or classical economics - proves that no such God or racist exists. The essay then surveys the historic misuses of evolutionary and economic rhetoric with regard to race, noting that such misuses depend on a self-serving appeal to the natural, simple, scientific inevitability of progress. The complex, interconnected historical development of religion, race, and evolutionary and economic theory are examined, and the essay argues that the rhetoric of economics often serves as a secular theology that functions to support Whiteness. The essay suggests that the fundamental questions of racial inequality are ultimately theological questions, and offers some avenues for finding common ground.
How Outcome Information Affects Ethical Attitudes and Intentions to Behave

ABSTRACT The purpose of this experiment is to examine how outcome information affects individual ethical attitudes and intentions to behave. In the present study, a scenario manager employs revenue...
‘I owe my life to the kind individual who called the helpline’: exploring the interplay of self-views and social distance in narrative advertising on domestic violence prevention in India and the United States

The persuasiveness and popularity of narratives in commercial advertising has gained much attention but its application in inculcating responsible behaviour is severely limited. Domestic violence a...
Resource Allocation for Wireless Power Transmission Enabled Full-Duplex OFDMA Mobile Wireless Networks

We investigate the resource allocation to enable wireless power transmission over a full-duplex (FD) wireless network, where an access point (AP) conducts downlink wireless information and power transfer (WIPT) to multiple mobile users, and in the meantime receives uplink information from the mobile users. To enable downlink WIPT, mobile users employ the power splitting technique to harvest energy and receive information from the received radio frequency (RF) signals concurrently. In particular, the system adopts the non-orthogonal multiple access (NOMA), and then multiple mobile users can leverage the same subcarriers for data transmission and reception. We maximize the minimum (max-min) uplink transmit rate among all mobile users to guarantee their fairness, where the subcarrier allocation, power allocation, and power splitting ratio selection are jointly optimized. Due to using NOMA, the formulated optimization problem is non- convex. Consequently, we develop the suboptimal scheme, by converting the non-convex objective function into a concave function and solving the formulated optimization problem using the convex programming and linear-programming. Finally, we validate and evaluate our proposed scheme through the numerical analyses.
Partial Ureteral Obstruction and Renal Function

Publisher Summary This chapter focuses on the partial ureteral obstruction and renal function. Ureteral obstruction is generally considered only in terms of its effect on the reduction of glomerular filtration rate of the whole kidney. The alteration of renal function may be quite different with two varying degrees of ureteral obstruction, that is, obstruction leading to two different values of ureteral pressure. The final osmolality of urine depends upon many factors, one of which must be the flow rate through the tubules in the region of the counter-current system. Any change in these rates of flow should cause alterations in the ability of the kidney to form a concentrated urine. With increased ureteral pressure, the rate of secretion of renin is also altered, which in turn may affect the renal transport of Na directly or indirectly by altering the output of aldosterone.
Delay Parameter Selection in Permutation Entropy Using Topological Data Analysis.

Permutation Entropy (PE) is a powerful tool for quantifying the predictability of a sequence which includes measuring the regularity of a time series. Despite its successful application in a variety of scientific domains, PE requires a judicious choice of the delay parameter $\tau$. While another parameter of interest in PE is the motif dimension $n$, Typically $n$ is selected between $4$ and $8$ with $5$ or $6$ giving optimal results for the majority of systems. Therefore, in this work we focus solely on choosing the delay parameter. Selecting $\tau$ is often accomplished using trial and error guided by the expertise of domain scientists. However, in this paper, we show that persistent homology, the flag ship tool from Topological Data Analysis (TDA) toolset, provides an approach for the automatic selection of $\tau$. We evaluate the successful identification of a suitable $\tau$ from our TDA-based approach by comparing our results to a variety of examples in published literature.
Weight-Related Communications Between Oncology Clinicians and Women With Obesity at Early Breast Cancer Diagnosis: Findings From a Review of Electronic Health Records.

Background: The American Society of Clinical Oncology (ASCO) Position Statement on Obesity and Cancer notes that the oncology care team is in a unique position to initiate weight management convers...
Information for Submitting to Specialty Law Reviews and Journals in Gender, Women & Sexuality

The following materials, modeled after the chart prepared by Professor Allen Rostron and Professor Nancy Levit at the University of Missouri Kansas City School of Law, and after my Information for Submitting to Online Law Review Companions, contains information about twenty-nine (29) U.S.-based law reviews and journals classified under the subject “Gender, Women and Sexuality” by the Washington & Lee Law Journal Rankings (here) and five (5) additional journals that contain the word “gender” in their title, but that are not listed in the Washington & Lee Law Journal Rankings. Within each category (W&L-ranked journals, then non-ranked journals) journals are listed in the order of the “rank” of the school, if any (as determined by the most recent US News overall ranking, not because that system merits endorsement, but because it is convenient). Specifically, the chart derives from the journals’ websites the following information: • Name of the specialty journal • Word count limitation, if any • Preferred submission method • Whether articles from online journal are included in HeinOnline’s Law Journal Library • Other information of possible interest to authors • US News ranking of affiliated school, if any • W&L Law Journal Ranking within category of “Gender, Women and Sexuality,” by “combined” score for 2017 (most recent year available). For further information concerning the rankings of the journals and their associated law schools, please consult the source of your choosing. Many colleagues find the Washington & Lee law review rankings website helpful. The author welcomes corrections and additions to this chart.
Utility of Dermatology Extension for Community Healthcare Outcomes (ECHO) sessions in the adult and paediatric population

IntroductionPrimary care provider (PCP) competency in dermatology is inadequate despite the high volume of patients with skin conditions. Better education and access to dermatology expertise is vit...
Design of Robust Lyapunov-Based Observers for Nonlinear Systems With Sum-of-Squares Programming

In this letter, we consider the problem of designing robust observers for uncertain polynomial systems. The results are applicable to polynomial systems with dynamics that are affine in the control and disturbance variables, and a perturbed linear output model. The input and disturbance variables can take values in convex and compact polytopes. We use sum-of-squares (SOS) methods to synthesize a Lyapunov-based robust state observer. In particular, given the dynamics of the observed system and the explicit robustness bounds, the polynomial dynamics of the observer and a worst-case convergence bound are obtained through the solution of an appropriately formulated SOS program. We also discuss an extension of the proposed class of robust observers that is applicable to the distributed state observation problem for uncertain networked polynomial systems.
Spastic Motor Disorders

Spastic esophageal disorders are currently comprised of three main clinical entities, distal esophageal spasm (DES), hypercontractile or jackhammer esophagus, and type III (spastic) achalasia, as defined by high-resolution esophageal manometry. While no population-based studies exist for non-achalasia esophageal motility disorders, the prevalence of DES is thought be similar to that of achalasia, approximating 1 in 100,000 in the USA. Recent studies also estimated that 1–4% of patients undergoing esophageal manometry for dysphagia and/or chest pain demonstrate findings suggestive of a spastic disorder.