cssi/SciSciGPT-SciSciNet huggingface dataset:
The clinical significance of cereblon expression, as an effective therapeutic target, in patients with diffuse large B-cell lymphoma

S74 Caribbean, and rarely encountered within the United States. ATLL is sub-divided in 5 categories: acute, lymphomatous, chronic, smoldering, and Hodgkin like. Much is still to be established with this rare disease including a standard of care. The high prevalence of patients with HTLV-1 ATLL in the Caribbean places our institution within close proximity as opposed to other areas of the United States. Methods: We identified HTLV-1 ATLL patients treated at Moffitt Cancer Center (MCC). Records were reviewed for demographics, disease features, and outcomes. Results: Ten ATLL patients were treated at MCC over the past 5 years. The median age was 56 years. Six patients were females and 7 were originally from the Caribbean. Seven patients were leukemic subtype, 9 patients had lymphadenopathy, 7 patients had bone marrow involvement, 5 had skin rash, 1 patient had bone disease, and none of the patients had hepatosplenomegaly, nor CNS disease. The mean hemoglobin was 12 g/dl, WBC 17/mcl, and platelets 266/mcl. All patients had hypercalcemia (mean serum calcium 11.7mg/dl), the mean serum LDH was 1238 U/L. By immunophenotype, all cases were CD3+, 90% CD5+, 80% CD25+, and 10% CD30+. Seven patients received CHOP regimen as first line therapy, and 2 patients interferon/zidovudine, 1 patient had VCAP-AMP-VECP. Only 1 patient had complete response (CR) to first line therapy, 4 had partial responses, and 3 had progressive disease. Subsequent therapy included interferon/zidovudine in 2 patients, HyperCVAD 2 patients, ESHAP 2 patients, and ICE, IGEV, pralatrexate, and denileukin difitox in 1 patient each. Three patients proceeded to allogeneic stem cell transplant (ASCT). The median overall survival (OS) was 51 months (mo). The median OS was 88 mo among those who underwent ASCT versus 34 mo for those who did not. Conclusion: HTLV-1 ATLL is associated with poor outcomes. Response to CHOP chemotherapy is poor. Best outcomes were achieved if patients proceeded to ASCT in CR1.
Are Two Heads Better than One? Crowdsourced Translation via a Two-Step Collaboration of Non-Professional Translators and Editors

Crowdsourcing is a viable mechanism for creating training data for machine translation. It provides a low cost, fast turnaround way of processing large volumes of data. However, when compared to professional translation, naive collection of translations from non-professionals yields low-quality results. Careful quality control is necessary for crowdsourcing to work well. In this paper, we examine the challenges of a two-step collaboration process with translation and post-editing by non-professionals. We develop graphbased ranking models that automatically select the best output from multiple redundant versions of translations and edits, and improves translation quality closer to professionals.
Hyaluronic acid versus saline intra‐articular injections for amelioration of chronic knee osteoarthritis: A canine model

The objective of this study was to assess the safety and efficacy of intra-articular injections of hyaluronic acid (HA) versus saline for symptomatic treatment of osteoarthritis (OA). Twenty-five adult purpose-bred dogs underwent meniscal release of one knee. Clinical, arthroscopic, and radiographic signs of OA were confirmed in all dogs prior to treatment. Dogs were randomized into five groups: HA-1 (n = 5), HA-3 (n = 5), HA-5 (n = 5), Saline-1 (n = 5), and Saline-3 (n = 5). Each dog received intra-articular injections of the respective substance into the affected knee at the pre-determined time points. Dogs were assessed for heat, swelling, and erythema after each injection and for lameness, pain, effusion, range of motion, kinetics, radiographic OA scoring, and arthroscopic scoring prior to treatment and for 6 months after injection. Dogs were then humanely euthanatized and the knees assessed grossly and histologically. Only mild heat, swelling, and/or erythema were noted in some dogs following injection and resolved within 1 week. Dogs treated with HA-1, HA-3, and HA-5 were significantly (p < 0.05) better than dogs treated with Saline-1 and Saline-3 at the 4, 8, and 12 week time points based on at least one outcome measure. OA severity was not significantly different among groups at any time point, but increased in severity over time in all groups. Gross and histologic OA scores were not significantly different among groups. These data suggest the three HA injection protocols were safe, superior to saline for short-term amelioration of symptoms associated with chronic OA, and can be translated to human OA treatment. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1772-1779, 2016.
Paper documents and copper-plates: localization of hegemonic practices

This paper examines the social currency of copper-plate charters on the basis of Persian copper-plates from the Deccan. Indic religious systems have a long tradition of conferring land grants using this medium, partially rooted in beliefs of metaphysical qualities attributed to metals. The objects from this region are highly unusual because there are no other recorded instances of a sultan issuing or authorizing land grants on copper-plates. The Persian-language copper-plates appear from the sixteenth century onwards, and seem to be later copies of (or extracts from) paper-based charters issued by Bahmani sultans and other kingdoms in the Deccan. Issues of authenticity and forgeries, fakes and copies are also raised in this paper. This study examines objects that combine material culture and textual content. While the textual content of these objects has always been privileged as being a source of history, the medium – which itself has a history of reception – has not been given its own historical narrative. The paper provides new perspectives on what we might call the “social life” of different documentary formats in medieval and early modern India, in particular the copper-plate grant.
Simulating Variability of Rework Cost and Market Performance Estimates in Product Redesign

When considering the redesign of an existing product, designers must consider possible engineering and marketing ramifications. Ideal changes capture a large portion of the market and have a low risk of change propagation that results in reduced cost to the manufacturer. Engineering change tools such as the Change Prediction Method and market research models such as Hierarchical Bayes Mixed Logit allow designers to estimate the cost of the redesign process and market shares of preference. Variability in the inputs of the Change Prediction Method (impact and likelihood values) results in a range of redesign cost values. Assumptions regarding model form and the randomness used in model fitting also lead to variations when estimating market performance. When the variability associated with these techniques is considered, focus should shift from a point-estimate to a region-estimate. This paper explores the region-estimate produced for proposed redesigns when considering rework cost and market share of preference.Copyright © 2015 by ASME
Spin-wave resonances in the presence of a Bloch wall

In-plane magnetized films of CoTaZr demonstrate standing spin-wave resonances in the complex permeability spectra well below the ferromagnetic resonance frequency. From detailed analysis of the static field dependence of the modes combined with observation of the domains using Kerr microscopy, we show that these modes originate from spin waves within the Bloch walls where the magnetization rotates perpendicular to the plane of the film. Unlike spin waves typically described in perpendicularly magnetized films, the frequencies involved are much lower due to unique field dynamics inside the wall. This theory can be fully understood by incorporating these observations into an analytical model using the Landau-Lifshitz-Gilbert equation, with good agreement between model and experimental measurement.
Pharmacologic Management of the Critically III Patient in the Perioperative Period-Emphasis on the Sepsis Syndrome

The critically ill perioperative patient requires complex pharmacologic management. The ability to measure circulating drug concentrations has helped the clinician to properly modulate therapy, especially with potentially toxic agents. Postoperative sepsis remains a difficult therapeutic problem. Controversial therapies, such as the use of corticosteroids and the utility of newer pharmacologic approaches, are beginning to be properly tested in multicenter trials. Improvements in technology (e.g., development of monoclonal antibodies), biochemistry, and pharmacology have resulted in the development of exciting, new pharmacologic avenues for the management of the critically ill perioperative patient.
Incestuous sexual abuse themes in contemporary novels for adolescence: A cultural study

Based on qualitative methodology, this study investigated ten contemporary novels written especially for adolescents having incestuous sexual abuse as their major themes. Data were obtained through clinical‐format case history reports prepared on each novel. Findings showed that incest usually involved daughter‐father and niece‐uncle pairs, and for father‐daughter relationships the incest always included intercourse. In all cases the incestuous affairs ended with consequences for the adult offenders. In most cases authors pictured incest as an assault against the innocent, but they often saw the incest abuser, especially fathers, as victims of themselves and rarely was the father punished with prison. Although authors presented incestuous families as psychologically dysfunctional, the adolescent victims were given intelligence and determination enough to escape from the incest and to rebuild their lives.
35 CARDIOVASCULAR SCREENING USING PULSE PRESSURE RESPONSE TO HANDGRIP.

Our pilot studies (PS) show that pulse pressure (PP) response to isometric handgrip (IH) provides significant additional information in the prediction of cardiovascular (CV) disease. The combination of the PP and the rise in pulse pressure (RPP) during IH enabled the prediction of high systemic vascular resistance (SVR), low cardiac output (CO), degree of BP control, aortic collagen, and coronary artery (CA) risk. Prospective studies (ProS) were done using a random sample of the general population, ages 50-65, 1/1 male/female, all Caucasian, compared to normal controls (C) (matched by age/sex and race). BP was recorded (left arm) at rest and with IH (right hand at 5 psi for 3 minutes) recording RPP. Measurements were made of systolic blood pressure (SBP), PP, RPP, systolic time intervals (STI), systemic vascular resistance (SVR in standard units), and CO and aortic collagen (AC) by transthoracic 2D echocardiography. PP and RPP were used to predict right coronary artery stenosis (RS), left anterior discending stenosis (LS), and circumflex stenosis (CS) by previous PS predicted-found formula vs angiogram (r = .96, p 125. Group (G) 3 was treated (3Rx) with tenormin 12.5-100 mg/day for 10 years with IH measured every 3 months and all other serial measurements made annually. All data were placed into a blind matrix for analysis later. Data were grouped using PP and RPP PS criteria. Results Group means are shown. X = Not measurable due to high SVR.
Analysis of HIV voluntary counseling and testing data in Zhongshan City,2010-2012

Objective To understand HIV positive rate and its correlation among voluntary counseling and testing(VCT) in Zhongshan City,Guangdong Province.Methods The VCT data during 2010 to 2012 in Zhongshan City were downloaded from China information system for disease control and prevention.HIV and syphilis serological detection were performed for all VCT participants.The HIV positive rates were analyzed using the single factor and multifactor unconditioned logistic regression.Results Three VCT sites received 3 613 clients during 2010 to 2012.Of the 3 601(99.7%) clients having HIV test,212(5.9%) were positive.The HIV positive rates were 5.8%(173 /2 972) for male and 6.2%(39/629) for female.Of the 2 759 clients having syphilis test,121(4.4 %) were positive.The syphilis seropositive rate was 4.9%(117 /2 389) for male and 1.1%(4 /370) for female.The HIV positive rate for syphilis seropositive clients was 25.6%(31 /121).The HIV positive rates were 66.7%(8 /12) for those suspected positive in history test,17.6%(3 /17) for those with blood transfusion or sale history,13.1%(29 /221) for those having a positive regular sexual partner,12.7%(8 /63) for those injecting drug use,10.4%(114 /1 096) for those men who had sex with men(MSM),6.3%(3 /48) for those with sex transmitted disease history,5.9%(4 /68) for those having a regular sexual partner with high risk behaviors,3.0%(1 /33) for those whose mothers were HIV positive,2.5%(22 /896) for those with unmarried heterosexual behaviors,and 2.4%(20 /825) for those with commercial heterosexual behaviors.Clients with occupation exposure,positive family members except for the mother,unsafe behaviors such as exelcymosis and needling,health examination,or fear of AIDS were all screened to be HIV negative.The multifactor logistic regression model showed that,the lower level of education(AOR = 1.39),had a higher risk to be HIV positive;clients with syphilis seropositive tests were 4.14 times the risk to be HIV positive compared to those with syphilis seronegative tests;MSM were 4.78 times the risk to be HIV positive compared to those with unmarried heterosexual behaviors,and those with a positive regular sexual partner were 4.71 times the risk to be HIV positive compared to those with unmarried heterosexual behaviors(all P 0.01).Conclusion Clients of the low level of education,the syphilis seropositive,MSM,and those with a positive regular sexual partner have a relative high HIV infection rate.It is necessary to take more comprehensive and effective prevention measures and intervention.
The influence of age and diabetes on the skin blood flow response to local pressure.

BACKGROUND Previous data has shown that when pressure is applied to the skin of the ankle and on the foot, there is a reactive increase in circulation. In the present investigation, these studies were expanded to look at the response of the hand, back, and foot to applied pressure. MATERIAL/METHODS Ten young subjects whose average age was 26.5+/-3.3 yrs, 10 older subjects whose average age was 73.3+/-19.7 yrs and 10 people with diabetes whose average age was 60.1+/-5.7 yrs participated in the study. There was no statistical difference in the height or weight of the subjects. Hemoglobin A1c of the group with Diabetes averaged 6.98+/-1.15% with the mean duration of diabetes 13.6+/-9.5 yrs. An infrared laser Doppler flow meter was used to measure circulation on the hand, lower back, and on the bottom of the foot during applications of pressure at 15, 30, 45, and 60 kPa. RESULTS For all three areas of the body, circulation was significantly less in the group with diabetes than the other two groups (p<0.05). When pressure was applied at 15 kPa, the blood flow to the skin initially decreased, but then increased in the younger subjects and in the older subjects but did not increase in subjects with diabetes for any area of the body. Further, after pressure was released, for any of the four pressures examined here, while the younger subjects showed a pronounced reactive hyperemia, subjects with diabetes showed a diminished hyperemia not proportional to the pressure that was applied. CONCLUSIONS It appears that the normal protective mechanism of a pressure induced hyperemia is absent or diminished in patients with diabetes with more effect on the periphery than on the core area of the body. More importantly, after pressure was applied and released, subjects with diabetes lacked a proportional hyperemia to recovery form the transient ischemia of the pressure.
Hg 1-x Cd x Te nonlinear Fabry-Perot filters for optical limiting at 10.6 mµ

Recently, the nonlinear Fabry-Perot (F.P.) interferometer has been actively studied for optical bistability1 and power limiting2 applications. The basic concept of power limiting in the transmission mode is as follows. The spectral transmission window of the nonlinear F.P. filter is intially tuned to the laser wavelength of interest. When a laser pulse is incident on the filter the optical intensity within the filter changes the refractive index of the nonlinear medium, which thereby detunes the position of the filter transmission window from the laser wavelength.
Cones, creases and crumpled sheets

We know from everyday experience that a sheet of paper will crumple when crushed. Crumpling occurs in many other systems and over a variety of scales, ranging from membranes inside living cells to the buckling of cylinders in civil engineering. But no-one has so far been able to describe how a sheet crumples and what shape the crumpled object adopts. Now, however, two independent studies could provide the first steps towards solving this problem.
A convex method for learning d-valued models

Learning structurally constrained models such as sparse or group-sparse vectors, low-rank matrices, etc. is an important topic in machine learning. In this work, we consider vectors with only a few distinct values which we call d-valued vectors. This structure is useful when there are relations between the covariates in a regression task, or similarity between features in a classification problem. We introduce the d-variation norm as a penalty to promote this structure, and obtain useful optimization tools for this norm, such as its proximal operator, computed by solving a convex quadratic program. Some extensions such as matrix norms have been presented. The usage of this norm in a classification problem has been exemplified.
Tacit knowledge strategic use in organizations — A new model for creation, sharing and success (September 2016)

Tacit knowledge in many situation is as useful as-or maybe more useful-than explicit knowledge. It is usually acquired from employees' life-time experience and practical interaction with real-life work challenges. This paper discusses the importance of tacit knowledge in organizations in the new era, the strategic use of tacit knowledge as a competitive advantages, the effect of social networks and advances in communications in collection and conversion of tacit knowledge to explicit knowledge. The paper also proposes a new model for tacit knowledge creation, conversion, sharing and success.
Facile detection of polycyclic aromatic hydrocarbons using photonic biosilica combining surface-enhanced Raman spectroscopy and thin layer chromatography

We developed a facile route for separating and detecting polycyclic aromatic hydrocarbons from mixed samples using photonic biosilica, which serves as a new lab-on-chip platform combining surface-enhanced Raman scattering sensing and thin layer chromatography.
Predictive radiogenomics modeling of EGFR mutation status in lung cancer.

Molecular analysis of the mutation status for EGFR and KRAS are now routine in the management of non-small cell lung cancer. Radiogenomics, the linking of medical images with the genomic properties of human tumors, provides exciting opportunities for non-invasive diagnostics and prognostics. We investigated whether EGFR and KRAS mutation status can be predicted using imaging data. To accomplish this, we studied 186 cases of NSCLC with preoperative thin-slice CT scans. A thoracic radiologist annotated 89 semantic image features of each patient’s tumor. Next, we built a decision tree to predict the presence of EGFR and KRAS mutations. We found a statistically significant model for predicting EGFR but not for KRAS mutations. The test set area under the ROC curve for predicting EGFR mutation status was 0.89. The final decision tree used four variables: emphysema, airway abnormality, the percentage of ground glass component and the type of tumor margin. The presence of either of the first two features predicts a wild type status for EGFR while the presence of any ground glass component indicates EGFR mutations. These results show the potential of quantitative imaging to predict molecular properties in a non-invasive manner, as CT imaging is more readily available than biopsies.
The Telephonic Self: Non-Systemic Systems and Autobiographical Self-Representation

This chapter argues that despite the alternative forms of narrative available at the turn of the century, Henry Adams stubbornly persists in his belief that historical and personal narrative are viable forms for historiography. Adams organizes The Education of Henry Adams according to the logic of what I call a non-systemic system, one that resembles contemporary communication systems including the early telephone network. The conception of being and writing that this chapter calls the “telephonic self” enables Adams to resist what he sees as the inertial ennui of modernity by continuing to register his complaints with the modern project.
Environmental Federalism: Empirics

This article reviews the empirical literature on environmental federalism – the division of environmental regulatory authority between national and subnational governments. It discusses economic concepts and findings pertinent to a variety of issues affecting environmental policy in federal systems, including regulatory responsiveness to local constituencies, the effect of devolution on environmental quality, environmental free riding, and the possibility of an environmental race to the bottom.
Grading matters in theological education

Grading systems matter more to the teaching and learning enterprise than many teachers may realize, as demonstrated in the author's experience of adopting a new one. Different systems emphasize different values such as excellence vs. perfection, achievement vs. talent, and second chances vs. partial credit. The author relates her experiment with specifications grading, an outcome-based, pass/fail, rubric-based, and contractual grading system, and demonstrates its promise. She then addresses three questions her experiment raised: Should I grade at all and if so, toward what end? Exactly what am I grading when I grade? and Is there any way to lessen the sting of failure?
A theory of subfeatural representations: the case of rounding harmony in Laal*

This paper introduces subfeatural representations to capture subphonemic distinctions at work in ‘subphonemic teamwork’. The unusual case of Laal is presented, in which rounding harmony requires two triggers: a round vowel and a labial consonant. The coarticulatory effect of the labial consonant is shown, on the basis of instrumental evidence, to incur a distinctive, but non-contrastive, intermediate level of rounding on the target vowel, analysed as being featurally [−round], but subfeaturally 〚xround〛 (0 < x < 1). 〚xround〛 vowels are shown to form a separate natural class, which can be independently targeted by phonological processes. Subfeatural representations are argued to constitute an advantageous reification of phonetic knowledge, forming a more solid basis for phonetically driven models of phonology. This proposal builds on the insights of previous literature that perceptual representations are needed in phonology, while eschewing the need for direct reference to phonetics.
A Middle-School Code Camp Experience Emphasizing Data Science for Social Good: (Abstract Only)

The underrepresentation of women, students of color, and people from lower-SES (socio-economic-status) backgrounds within computer science remains a national issue. Recent studies demonstrate one reason: persistent stereotypes about "who does computer science" can cause minority groups to preclude interest in the field. Unfortunately, these stereotypes are not the only threat to diversifying the discipline. Engaging a diverse group of individuals in computer science is unlikely so long as computing curriculum is perceived as "irrelevant" and "asocial/". Confronting the stigma of triviality applied to computer science, much like approaching student perceptions about who can do computer science, is a necessary step for increasing the perceived applicability of the discipline. As a step in combating the perception that programming curriculum is irrelevant, we developed and ran a week-long summer coding camp for local middle school students that camp applied principles of computing for social good with data science approaches to encourage campers to consider how computing could help them explore societal issues. Throughout the week, campers learned how to extract meaning from their work and gained experience collaborating in pairs to solve problems. In this poster, we discuss the camp curriculum and its emphasis on the applications of computing. We consider the effects of the camp on the self-efficacy of campers and their perceptions of computer science. We then present some recommendations for those intending to conduct similar camps.
Examining Distance Education Coursetaking and Time-to-Completion among Community College Students

ABSTRACTThe discrepancy in the empirical literature surrounding distance education (DE) coursetaking among community college students has led to the online paradox, where short-term or more proximal academic outcomes associated with DE coursetaking are negative, but the long-term or distal academic outcomes are positive. Importantly, no previous study has yet examined the relationship between DE enrollment and the time it takes community college students to complete their degree programs or succeed in transferring to a four-year school. This gap in the research literature is unfortunate, as understanding the relationship between DE and time-to-completion may shed light on mechanisms underlying the online paradox. Consequently, the current study looks at the relationship between DE coursetaking and time-to-completion among first-time community college students. The study uses large, nationally representative data and propensity score matching (PSM) to mitigate the impact of self-selection into DE courses. ...
The Intracellular Loop of the Na+/Ca2+ Exchanger Contains an “Awareness Ribbon” Shaped Two-helix Bundle Domain

The Na+/Ca2+ exchanger (NCX) is a ubiquitous single-chain membrane protein that plays a major role in regulating the intracellular Ca2+ homeostasis by the counter transport of Na+ and Ca2+ across the cell membrane. Other than its prokaryotic counterpart, which contains only the transmembrane domain and is self-sufficient as an active ion transporter, the eukaryotic NCX protein possesses in addition a large intracellular loop that senses intracellular calcium signals and controls the activation of ion transport across the membrane. This provides a necessary layer of regulation for the more complex function of eukaryotic cells. The Ca2+ sensor in the intracellular loop is known as the Ca2+-binding domain (CBD12). However, how the signaling of the allosteric intracellular Ca2+ binding propagates and results in transmembrane ion transportation still lacks a detailed explanation. Further structural and dynamics characterization of the intracellular loop flanking both sides of CBD12 is therefore imperative. Her...
Structural and inflammatory changes in the airways of asthmatics

These studies support the role of airway wall inflammation in bronchial asthma, confirm the involvement of eosinophils and their degranulation and implicate, further, T lymphocytes and interleukin 5 as controllers of the eosinophilic response. Several factors may contribute to apparent airways hyperresponsiveness including fragility of surface epithelium, thickening of the airway wall, uncoupling of airway wall and parenchyma or loss of lung elastic recoil. Thickening of the airway wall may be due to bronchial vessel dilatation and oedema, or enlargement of the mass of bronchial smooth muscle or mucus-secretory glands. Each of these changes may be induced by the inflammatory cells which infiltrate the airway wall in both mild and severe asthma: their predominant cytokine products can clearly influence the characteristic profile of cell phenotypes, their activation and the chronicity of the inflammatory response. In this regard, mast cells and lymphocytes may be important initiators and controllers, whilst activated eosinophils are key reactor cells whose increased presence is associated with increased airways responsiveness.
Spin Spectroscopy and Coherence in Magnetic Quantum Structures

The study of electronic spin dynamics and coherence is central to gaining insights into a variety of contemporary problems in condensed matter physics. In particular, there is substantial current interest in understanding spin-dependent phenomena in materials systems that involve interfacial and confined geometries such as semiconductor quantum wells [1], metallic magnetic multilayers [2], granular magnetic materials [3], and magnetic semiconductor (MS) quantum structures [4]. For instance, a detailed understanding of electronic spin scattering in low dimensional systems can provide important clues about the fundamental origins of the giant magneto-resistance observed in multilayered and granular magnets. Furthermore, investigations of spin coherence in quantum semiconductor structures are important for exploring coherent spin behavior in solid state systems as a basis for quantum computation and for new generations of magneto-electronic devices [5,6]. In this chapter, we focus on experiments that probe the fundamental spin dynamical properties of a low dimensional (i.e. d < 3) electron or exciton gas that is strongly exchange coupled to a controlled distribution of local moments. We have recently carried out a systematic and detailed study of dynamical spin interactions in such systems by exploiting the concurrent development of sophisticated magnetic nanostructures (e.g. digital magnetic heterostructures and magnetic two-dimensional electron gases) and spatio-temporally resolved spin dynamical probes (e.g. ultrafast Faraday rotation and near-field scanning optical microscopy).
Crisis and austerity: the recent trajectory of capitalist development in Brazil

In the methodological framework of comparative capitalism (CC) of this special edition, the article analyzes theoretically and empirically, in the scope of economic globalisation, the recent trajec...
Authoritarian Deliberation: Public Deliberation in China

Public deliberation has long been recognized as a cornerstone of participatory democracy and representative government. However, its potential in non-democratic societies is largely unrealized. The paper draws on Western theories of public deliberation and discusses the characteristics of China’s deliberative experience. Online deliberation in both Western and Chinese societies is also considered as an extension of offline activities. The concept of authoritarian deliberation is employed to recognize the substantial amount of public deliberation about policy within an authoritarian state and to distinguish it from that in democratic countries.
Labeling Theory, The Power of Words, and Implicit Bias

This chapter focuses on labeling theory (the impact of labels), the power of words, and implicit bias. Trauma-informed approaches compel us to focus on narrative and chose our words wisely. We impact positive change when we build positive environments with positive narrative. Several sociological studies powerfully demonstrate the connection between narrative and self-efficacy and construction of one’s identity. Positive words and reinforcement build confidence and confidence inspires change. Economists will tell you that the market does well when there is confidence in it. If this rationale holds true for markets, how much more so should it, can it be applied to people? All human beings are impressionable, but youth are incredibly impressionable. The objective of this chapter is to raise awareness (and provide tools for recognizing and managing narrative) around the impact and power of words and to challenge individuals (attached to systems) to work toward changing their narrative so that they increase the risk of facilitating the kind of change they seek in youth.
Novel Synthesis of Potent Site-Specific Phospholipase A2 Inhibitors

Phospholipase A2 (PLA2) is an esterase responsible for the liberation of phospholipid-bound arachidonic acid, a biosynthetic precursor of putative inflammatory mediators. Arachidonic acid is metabolized by cyclooxygenase and lipoxygenase to the corresponding prostaglandins and leukotrienes (Fig. 1). Traditional antiinflammatory therapy has relied on cyclooxygenase and more recently on lipoxygenase blockade (Shen, 1981), but direct control of arachidonic acid pools has remained relatively unexplored. Recent evidence (Hirata et al., 1980; Blackwell et al., 1980; Rothhut et al., 1983) demonstrates that antiinflammatory steroids control polyunsaturated fatty acid release at both cyclooxygense and lipoxygenase pathways by enhancing the production of PLA2 inhibitory proteins (lipomodulin, macrocortin, renocortin). Direct phospholipase A2 site-specific inhibition, therefore, offers new opportunities in antiinflammatory treatment.
UNCOMMON FORM OF ECTODERMAL DYSPLASIA: TRICHO-DENTO-OSSEOUS SYNDROME

Background Tricho-dento-osseous syndrome (TDOS) is an autosomal dominant genetic disorder, which is characterized by inherited defects in tissues that arise from epithelial–mesenchymal interaction. The minimal diagnostic criteria for TDOS include enamel hypoplasia, posterior taurodonts, autosomal dominant inheritance pattern, tightly curly hair at birth, and/or radiographic evidence of bone sclerosis. Some authors have questioned whether amelogenesis imperfecta of the hypomaturation–hypoplasia type with taurodontism (AIHHT) and TDOS are distinct conditions or denote a spectrum of the same disease. Objective(s) The aim of this study was to increase awareness of TDOS. Results A 25-year-old female patient was seeking restorative treatment for the yellowish-brown discoloration of her teeth. Clinical evaluation revealed that she had multiple missing teeth, discolored teeth, frontal bossing, and a concave profile. She was otherwise healthy and not taking any medications. Her medical history indicated a previous diagnosis of ectodermal dysplasia (ED). Panoramic radiography and cone beam computed tomography (CBCT) revealed multiple missing and impacted teeth, as well as retained primary teeth. Reduction in enamel thickness on deciduous and permanent teeth was observed, in addition to taurodont appearance of second permanent molars. Generalized homogeneous ground-glass trabecular pattern in the maxilla and the mandible with a square shape of mandible was noted. Discussion/Conclusions In this report, we describe an unusual phenotype of ED, which represents a group of inherited conditions in which 2 or more ectodermally derived anatomic structures fail to develop. TDOS is an uncommon form of ED. The dental findings are clinically similar between TDOS and AIHHT; however, patients with AIHHT lack changes in their hair and bone. In cases where hair, bone, and nail changes are not significant, genetic analysis may help in differential diagnosis. TDOS is genetically linked to markers on chromosome 17 q21.
First-Trimester Ultrasound

Since the 1980s, development of high-resolution transvaginal ultrasound transducers has significantly improved ultrasound evaluation at earlier gestational ages. Although many indications exist for first-trimester ultrasound in pregnancy, more emphasis has been placed on assessment of fetal anatomy recently. In turn, congenital diagnoses can also be made earlier in pregnancy, raising the question of whether anatomic assessment in the first trimester is one of choice or obligation. Combining transvaginal and transabdominal approach yields the highest detection rate overall. Some studies have shown that more than half of all anomalies and almost all severe anomalies can be detected on early scans.
Factors Associated With Growth After Deceased and Live Donor Pediatric Liver Transplantation.

Abstract Background There are limited data on predictors of growth after pediatric liver transplantation. Methods We reviewed the impact of graft type, ethnicity, and biliary complications (BC) on growth after pediatric liver transplantation (LT). We compared preoperative and 6-, 12-, and 24-month weight, height, and body mass index (BMI) percentiles between living donor (LD), deceased donor full-size (DD-full), and deceased donor split (DD-split) graft recipients. We also compared length of stay (LOS) between groups. Results We had 98 patients (DD-split: 32; DD-full: 43, LD: 23). The Median Pediatric End-stage Liver Disease (PELD) scores, exception points, albumin, bilirubin, failure to thrive, and presence of ascites were similar among groups. The DD-full group had the lowest preoperative percentiles in all categories and exceeded these at 24 months. The DD-split group was at preoperative percentiles at 24 months. The LD group had parallel weight curves compared to the DD-full group and exceeded only the preoperative weight percentile at 24 months. Black patients had the lowest percentiles in all categories (P Conclusion DD-full and black patients seem to benefit the most from LT in terms of growth. BC seems to affect height percentiles. Patients with longer LOS had lower height and BMI percentiles (P>.05). Longer follow up and larger cohorts are necessary to improve the power of these findings.
Early versus Late Profiles of Inflammatory Cytokines after Mild Traumatic Brain Injury and Their Association with Neuropsychological Outcomes.

Despite pre-clinical evidence for the role of inflammation in traumatic brain injury (TBI), there is limited data on inflammatory biomarkers in mild TBI (mTBI). In this study, we describe the profi...
Energy-Efficient Computation Offloading in Delay-Constrained Massive MIMO Enabled Edge Network Using Data Partitioning

We study a wireless edge-computing system which allows multiple users to simultaneously offload computation-intensive tasks to multiple massive-MIMO access points, each with a collocated multi-access edge computing (MEC) server. Massive-MIMO enables simultaneous uplink transmissions from all users, significantly shortening the data offloading time compared to sequential protocols, and makes the three phases of data offloading, computing, and downloading have comparable durations. Based on this three-phase structure, we formulate a novel problem to minimize a weighted sum of the energy consumption at both the users and the MEC server under a round-trip latency constraint, using a combination of data partitioning, transmit power control and CPU frequency scaling at both the user and server ends. We design a novel nested algorithm consisting of an inner primal-dual algorithm and an outer latency-aware descent algorithm to solve this problem efficiently. Optimized solutions show that for larger requests, more data is offloaded to the MECs to reduce local computation time in order to meet the latency constraint, despite higher energy cost of wireless transmissions. Massive-MIMO channel estimation errors under pilot contamination also causes more data to be offloaded to the MECs. Compared to binary offloading, partial offloading with data partitioning is superior and leads to significant reduction in the overall energy consumption.
A qualitative content analysis of watchlists vs safelists: How do they address the issue of predatory publishing?

Abstract Predatory journals and publishers are a growing concern in the scholarly publishing arena. As one type of attempt to address this increasingly important issue, numerous individuals, associations, and companies have begun curating journal watchlists or journal safelists. This study uses a qualitative content analysis to explore the inclusion/exclusion criteria stated by scholarly publishing journal watchlists and safelists to better understand the content of these lists, as well as the larger controversies that continue to surround the phenomenon that has come to be known as predatory publishing. Four watchlists and ten safelists were analyzed through an examination of their published mission statements and inclusion/exclusion criteria. Notable differences that emerged include the remaining influence of librarian Jeffrey Beall in the watchlists, and the explicit disavowal of his methods for the safelists, along with a growing recognition that the “list” approach may not fully address systemic aspects of predatory publishing that go beyond the individual author's ethical decision-making agency.
Patient-reported Outcomes Measurement Information System (PROMIS) Scores for Children With Brachial Plexus Birth Injury.

BACKGROUND Patient-reported Outcomes Measurement Information System (PROMIS) for pediatrics is a validated patient-reported or parent-proxy-reported outcomes assessment tool used to evaluate health-related quality of life in children and adolescents with chronic medical conditions. The health-related quality of life of children with brachial plexus birth injury (BPBI) as measured by PROMIS is not well understood. We hypothesized that children with BPBI would report impaired upper extremity (UE) function but normal mobility, pain interference, and peer relationships compared with a reference pediatric population, and that UE function PROMIS scores would be associated with BPBI severity and patient age. METHODS This is a retrospective cohort study of 180 children with BPBI ages 5 to 17 years old who responded to 4 pediatric PROMIS domains (mobility, pain interference, peer relationships, and UE function) between April 2017 and April 2019. Responses were converted to a T score, which allows comparison with a reference pediatric population (mean reference score=50). Multivariable linear regression was used to quantify the association between PROMIS scores and age, sex, Narakas type, and composite Mallet score. RESULTS Children with BPBI had normal PROMIS mobility (49.6±8.5), pain interference (44.6±9.7), and peer relationships (52.4±10.6) scores, but reported mild impairment in UE function (40.8±12.1). Age (P<0.0001) and Narakas type (P=0.02) were associated with PROMIS UE function scores, but sex and composite Mallet scores were not. There were no significant associations between the other PROMIS domains and age, sex, Narakas Type, or composite Mallet scores. CONCLUSIONS Children with BPBI reported PROMIS scores for mobility, pain interference, and peer relationships similar to the reference population but impairment in UE function. Reported UE function decreased with increasing disease severity and increased with age. These PROMIS domains seem to be useful tools for the clinician to evaluate children with BPBI and better understand the challenges they face. Further study is needed to assess their utility in measuring the effects of treatment interventions. LEVEL OF EVIDENCE Level III.
Quantification and prediction of the thermal performance of cold-formed steel wall assemblies

Abstract Steel elements installed at or in the building envelope are susceptible to forming thermal bridges, where heat and energy are transferred from the building interior to the exterior. Thermal bridges have a negative impact on overall embodied energy in the structure, which can be compounded over the service life of a building. Furthermore, poor thermal performance also results in condensation and occupant discomfort. This work specifically examines the thermal behavior of cold-formed steel wall assemblies. These assemblies are typically comprised of studs and tracks, sheathed in gypsum and weather-proofing sheathing. Walls are repetitively framed. While the performance and efficacy of insulating materials and potential mitigation strategies is known, prior works have not examined the impact of specific detailing inherent to these wall systems. To determine the influence of these engineering decisions, a large parametric study of wall assemblies was conducted via three-dimensional steady-state thermal analysis. The parametric study included steel thickness, stud depth, stud spacing, and was conducted across ASHRAE 90.1 climate zones. The contribution of isolated details and the sensitivity of overall thermal performance to these details is presented herein. Comparisons to relevant design codes are presented and predictive methods for determining thermal performance of assemblies are proposed.
Atmospheric fate of formyl chloride and mechanisms of the gas-phase reactions with OH radicals and Cl atoms

Abstract Formyl chloride (HCOCl) is a major product in the atmospheric degradation of several chlorinated hydrocarbons, but its atmospheric fate is not well known. Here, the kinetics of HCOCl with OH radicals and Cl atoms were studied over the temperature range of 180 to 400 K using Canonical Variational Transition state theory including Small Curvature Tunneling correction (CVT/SCT). The obtained temperature-dependent rate coefficients for the reactions of HCOCl with OH and Cl are (1.86 ± 0.7) × 10−11 exp[(−1217 ± 19)/T] cm3molecule−1s−1 and (9.87 ± 0.6) × 10−12 exp[(−747 ± 33)/T] cm3molecule−1s−1, respectively. Reaction mechanisms and thermodynamic parameters for the title reactions were studied, and the atmospheric lifetime of HCOCl was determined.
Energy Management and Control of Networked AC-DC Microgrids to Enhance Resiliency

On account of the apparent benefits of microgrids (MGs) and trends in MGs deployment, it is expected that the future distribution grid will consist multiple MGs. The networked microgrid system (NMS) allows network formation with multiple possibilities, while continue to supply energy to critical loads and enhance resiliency of the distribution grid given extreme events. Interconnection architecture and energy management of the NMS will be challenging to meet resiliency requirements. The energy management of a single microgrid (MG) is widely reported in literature, however limited for a NMS. With the increased advantages of DC system, a NMS energy management and control architecture is proposed for a specific configuration of hybrid AC/DC system. The developed hierarchical decentralized droop control scheme can regulate the power exchange, control voltage and also facilitate the demand sharing of the NMS. The seamless ‘plug-in and -out’ of MGs in the NMS are validated using the dynamic modeling and simulation of the distribution feeders using PSCAD/EMTDC. Results are provided for normal operation and operation after adverse events.
From Chiefdom to State in Early Ireland

1. Theoretical considerations 2. The climate and geology of Clare 3. Clare's chiefdoms at the dawn of history 4. An early medieval chiefdom of northern Clare 5. Reconstructing the social order of Irish chiefdoms through settlement 6. Of settlements and boundaries: reconstructing the chiefdom of Tulach Commain 7. The rulers of Tulach Commain 8. The world of Brian Boroimhe 9. The world of Caithrem Thoirdhealbhaigh 10. The political topography of late medieval Clare 11. An overview of the social and political systems of Thomond.
The value of shared visual information for task-oriented collaboration

For several decades, researchers and engineers have struggled with the development of systems to support distance collaboration. The failure of many collaborative technologies is due, in part, to a limited understanding of how groups coordinate in collocated environments and how the coordination mechanisms of face-to-face collaboration are impacted by technology. The major goal of this thesis is to address this deficiency by building a theoretical understanding of the role that shared visual information plays in supporting group communication and performance during task-oriented collaboration. This understanding is developed over three major stages: (1) the development of a paradigm and a series of empirical studies that decompose the features of shared visual information and task structure and explore their interactions in detail, (2) the development and application of a methodology for describing the sequential structure of how visible actions support the understanding of discourse, and (3) the development of a computational model of discourse to further our theoretical understanding of the ways in which shared visual information serves communication in task-oriented collaborative discourse.