cssi/SciSciGPT-SciSciNet huggingface dataset:
Collection Assessment of Monograph Purchases at the University of Nevada, Las Vegas Libraries

The purpose of this article is to describe an assessment project of the monograph collection at the University of Nevada, Las Vegas (UNLV) Lied Library. The circulation statistics and in-house use of all monographs for the nine colleges at UNLV were assessed analyzing the last five years of data. The analysis included an assessment of the circulation statistics and in-house use of books purchased on an approval plan compared with books purchased by individual liaison librarians. The findings illustrated the fact that overall use of the monograph collection has declined over the past five years. The findings also showed that books purchased on an approval plan had slightly higher use than the books purchased by individual liaisons. The study shows that academic libraries need to monitor usage of the monograph collection to be certain that money is spent in the most efficient manner and that usage data can be helpful if there is a need to reduce budget allocations for monographs or if a reallocation of fund...
Lower bounds on the iteration time and the number of resources for functional pipelined data flow graphs

An algorithm is presented to determine two lower bounds in functional pipelined data path synthesis. Given an iteration time constraint and a task initiation latency, the algorithm computes a lower bound on the number of functional units required to execute the data flow graph (DFG) of a loop body, and given a resource constraint and a task initiation latency the algorithm computes a lower bound on the number of time steps required to execute the DFG. The lower bounds not only greatly reduce the size of the solution space, but also provide a means to measure the proximity of the final solution to an optimal one. The bounds are computed in polynomial time; therefore the algorithm is very effective, especially for large DFGs. Experiments indicate that the lower bound is very tight. For all of the test cases the difference between our solution and the optimal solution is not greater than one. >
The evolution of plant–insect mutualisms

Mutualisms (cooperative interactions between species) have had a central role in the generation and maintenance of life on earth. Insects and plants are involved in diverse forms of mutualism. Here we review evolutionary features of three prominent insect-plant mutualisms: pollination, protection and seed dispersal. We focus on addressing five central phenomena: evolutionary origins and maintenance of mutualism; the evolution of mutualistic traits; the evolution of specialization and generalization; coevolutionary processes; and the existence of cheating. Several features uniting very diverse insect-plant mutualisms are identified and their evolutionary implications are discussed: the involvement of one mobile and one sedentary partner; natural selection on plant rewards; the existence of a continuum from specialization to generalization; and the ubiquity of cheating, particularly on the part of insects. Plant-insect mutualisms have apparently both arisen and been lost repeatedly. Many adaptive hypotheses have been proposed to explain these transitions, and it is unlikely that any one of them dominates across interactions differing so widely in natural history. Evolutionary theory has a potentially important, but as yet largely unfilled, role to play in explaining the origins, maintenance, breakdown and evolution of insect-plant mutualisms.
Mean Centering in Moderated Multiple Regression: Much Ado about Nothing

Centering variables prior to the analysis of moderated multiple regression equations has been advocated for reasons both statistical (reduction of multicollinearity) and substantive (improved interpretation of the resulting regression equations). This article provides a comparison of centered and raw score analyses in least squares regression. The two methods are demonstrated to be equivalent, yielding identical hypothesis tests associated with the moderation effect and regression equations that are functionally equivalent.
Impact of Peer Evaluation Confidentiality on Student Marks

Although group work is commonly used in university-level instruction, social loafing, domineering team members, poor attenders, and inequitable distribution of marks have been identified as obstacles to team-based learning. Peer evaluation has been proposed as one vehicle to address these issues. For use in grading, peer evaluations are often anonymous; however, as tools to address team functioning, they should not be conducted anonymously, but rather with the results discussed as feedback. It has been suggested, however, that non-confidential peer evaluations will artificially elevate students’ marks. In this study, we investigated the impact of peer evaluation confidentiality on students’ marks. Without a weighted correction, confidential evaluations significantly dropped students’ marks while non-confidential evaluations raised them. Implications for practice are discussed.
Bourdieu and the logic of practice : Is all giving Indian-giving or is generalized materialism not enough?

I argue here that in the end Bourdieu's theory of practice fails to overcome the problem on which it expressly centers, namely, subject-object dualism. The failure is registered in his avowed materialism, which, though significantly “generalized,” remains what it says: a materialism. In order to substantiate my criticism, I examine for their ontological presuppositions three areas of his theoretical framework pertaining to the questions of (1) human agency (as seen through the conceptual glass of the habitus), (2) otherness, and (3) the gift. By scrutinizing Bourdieu's powerful and progressive social theory, with an eye to finding fault, I hope to show the need to take a certain theoretical action, one that is patently out of keeping with the usual self-presentation and self-understanding of social science. The action I have in mind is this: because the problem of subject-object dualism is in the first place a matter of ontology, in order successfully to address it there must take place a direct shift of ontological starting point, from the received starting point in Western thought to one that projects reality in terms of ambiguity that is basic. With this shift the dualism of subject and object dissolves by definition, leaving a social reality that, for reasons of its basic ambiguity, is best approached as a question of ethics before power.
Hepatic Artery Anomalies: Anatomy Review

In this letter, the authors properlyemphasize the importance of liver transplantation inthe study of the hepatic vascular anatomy. They reportand deﬁne as previously not described an anomaly ofthe hepatic artery observed in four procurements per-formed by their group. In those cases, an aberrant rightaccessory hepatic artery was originating from the celiactrunk.Recently our group published in the journal
Temperature Sensor in a Flexible Substrate

This paper presents the fabrication and measured performance of temperature sensors embedded in flexible polyimide substrates. The sensing material used for the temperature sensor was undoped amorphous silicon which was fabricated on a 35-m-thick layer of polyimide that serves as the flexible substrate. Another flexible polyimide superstrate layer of 35-40 m was spin-coated on top of the sensors to make sure the temperature sensors lie on a zero stress plane. The temperature coefficient of resistance was measured over the temperature range of 200- 360 K. The maximum temperature coefficient of resistance at 30 C was measured to be 0.0288 K-1. The effect of the flicker noise and voltage dependence of the voltage noise power spectral density exhibited by the sensor was evaluated. The normalized flicker noise coefficient was found to be 1.2 × 10-11.
Aberrations of TACC1 and TACC3 are associated with ovarian cancer

Dysregulation of the human Transforming Acidic Coiled Coil (TACC) genes is thought to be important in the development and progression of multiple myeloma, breast and gastric cancer. Recent, large-scale genomic analysis and Serial Analysis of Gene Expression data suggest that TACC1 and TACC3 may also be involved in the etiology of ovarian tumors from both familial and sporadic cases. Therefore, the aim of this study was to determine the occurrence of alterations of these TACCs in ovarian cancer. Detection and scoring of TACC1 and TACC3 expression was performed by immunohistochemical analysis of the T-BO-1 tissue/tumor microarray slide from the Cooperative Human Tissue Network, Tissue Array Research Program (TARP) of the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Tumors were categorized as either positive (greater than 10% of cells staining) or negative. Statistical analysis was performed using Fisher's exact test and p < 0.05 (single comparisons), and p < 0.02 (multiple comparisons) were considered to be significant. Transgenomics WAVE high performance liquid chromatography (dHPLC) was used to pre-screen the TACC3 gene in constitutional DNA from ovarian cancer patients and their unaffected relatives from 76 families from the Gilda Radner Familial Ovarian Cancer Registry. All variant patterns were then sequenced. This study demonstrated absence of at least one or both TACC proteins in 78.5% (51/65) of ovarian tumors tested, with TACC3 loss observed in 67.7% of tumors. The distribution pattern of expression of the two TACC proteins was different, with TACC3 loss being more common in serous papillary carcinoma compared with clear cell carcinomas, while TACC1 staining was less frequent in endometroid than in serous papillary tumor cores. In addition, we identified two constitutional mutations in the TACC3 gene in patients with ovarian cancer from the Gilda Radner Familial Ovarian Cancer Registry. These patients had previously tested negative for mutations in known ovarian cancer predisposing genes. When combined, our data suggest that aberrations of TACC genes, and TACC3 in particular, underlie a significant proportion of ovarian cancers. Thus, TACC3 could be a hitherto unknown endogenous factor that contributes to ovarian tumorigenesis.
Platelet-activating factor content in human spermatozoa and pregnancy outcome

Abstract Objective: To determine whether platelet-activating factor (PAF) content in human spermatozoa from an isolated population is related to fertilization and pregnancy outcome. Design: Prospective analysis of PAF content in human spermatozoa after a Percoll gradient wash and its relation to fertilization and pregnancy outcome. Setting: University-based reproductive genetics laboratory. Subject(s): Couples undergoing assisted reproduction. Intervention(s): Lipids extracted from Percoll gradient spermatozoa were quantitated for PAF content by a specific radioimmunoassay. Main Outcome Measure(s): The relation between spermatozoa-derived PAF levels and motility, concentration, morphology, and fertilization and pregnancy rates were determined by using regression analysis and the Student t -test. Result(s): Radioimmunoassay and regression analysis showed a significant and positive relation between PAF content in human spermatozoa and concentration and motility indices and implantation rate. Patients who became pregnant had a significantly higher PAF content in the spermatozoa used (7.285 pmol/10 6 cells) than did patients who did not become pregnant (2.990 pmol/10 6 cells). Conclusion(s): The PAF content in human spermatozoa has a significant and positive relation with motility and concentration indices and implantation rate. Pregnancy rates but not fertilization rates may be predicted by measuring PAF levels in an isolated subpopulation of human spermatozoa.
Characteristics of stop releases in American English spontaneous speech

Abstract This study examines the factors affecting the production of stop releases in American English spontaneous speech. Previous research has shown that releases are conditioned by phonetic and social factors. However, previous studies either rely exclusively on read speech, or for sociolinguistic studies, focus on phrase-final stops. In this study, spontaneous speech is collected from two sources: interviews from the non-profit StoryCorps project and from sentences spontaneously generated in a picture description task. Stop releases were examined before obstruents and nasals in word-medial position (e.g. rugby), word-final, phrase-medial position (e.g. They crack nuts), and pre-pausally (e.g. I look up). Phonetic factors taken into account include identity of the stop, directionality of place of articulation in the consonant cluster (front-to-back vs. back-to-front) and manner of C2. For the StoryCorps data, race of the speaker was also found to be an important predictor. Results showed that approximately a quarter of the stops followed by a consonant were released, but release was strongly affected by the place of the stop and the manner of the following consonant. Release of pre-pausal stops differed between black and white speakers; the latter had double the amount of final release. Other realizations of the stops, such as deletion, lenition, and glottalization are also analyzed.
Abstract PR01: Structural mechanism of sequence-specific 5-methylcytosine (5mC) recognition by AP-1 transcription factors

DNA methylation is generally known to inhibit transcription factor binding. However, this notion has been challenged with identifications of several transcription factors that preferentially activate methylated promoters in specific sequences. AP-1 transcription factor (c-Jun/c-Fos heterodimer), a master regulator of a wide range of cancer-related genes, has been shown to bind a novel consensus sequence (59-TGACTCG-39) in CpG methylation-dependent manner. In the fluorescence polarization-based DNA binding assay, both c-Jun/c-Fos heterodimer and c-Jun/c-Jun homodimer preferentially bind DNA containing the methylated consensus sequence compared to DNA with unmethylated sequence. Using a homodimer of c-Jun/c-Jun basic leucine zipper (bZIP) DNA binding domain, we have solved the X-ray structure of AP-1 in complex with an oligonucleotide containing the methylated consensus sequence. The structure reveals that a common motif conserved among bZIP proteins is involved in the specific recognition of methylated CpG by one monomer and TpG by the other monomer. Like 5mC, thymine (5-methyluracil) contains a methyl group at C5 position, and the similarity imposed by the methyl C5 preserves key structural features of DNA sequence recognized by AP-1. Our in vitro finding resonates with previous studies of AP-1-like transcription factors that preferentially bind methylated response elements. In light of such evidence, our characterization of AP-1 as a sequence-specific 5mCpG and TpG reader suggests a novel way in which DNA methylation may function to activate transcription in a methylation-dependent manner. Citation Format: Samuel Hong, Xiaodong Cheng. Structural mechanism of sequence-specific 5-methylcytosine (5mC) recognition by AP-1 transcription factors. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr PR01.
Synergistic thermoelectric power factor increase in films incorporating tellurium and thiophene-based semiconductors

Two thiophene-based semiconductors, a vapor-deposited small molecule and an amorphous polymer, as well as pentacene for comparison, show potential in enhancing the thermoelectric properties of tellurium (Te) nanowires. For vapor-deposited films, Te nanostructures form directly on glass substrates or organic semiconductor films. The resulting Te power factor (S2σ) was enhanced from 36 to 45 W/mK2 (56 for pentacene) because the bilayer provides an enhancement in Seebeck (S) without compromising conductivity (a). For solution deposited polymer blends, we obtained power factors from a Te nanowire network that alone would not have sufficient connectivity (up to 0.1 µW/mK2). While the organics are unoptimized, they are prototypical materials for further development.
Tyrosinase in Frozen Sections and Fragments of Mouse Skin.

SummaryNew histochemical demonstrations of tyrosinase activity in frozen sections and fragments of normal pigmented mouse skin are described. These demonstrations provide a basis for reconciling apparently conflicting results and interpretations arising from earlier studies, in which tyrosinase activity was not demonstrated, and later studies, in which this enzyme was readily demonstrated.
Biddability, Constructability, Operability, and Environmental Analysis at the Engineer Research and Development Center

The United States Army Corps of Engineers (USACE) created a checklist in order to ensure all proposed government projects meet a minimum set of guidelines. They coined the checklist BCOE: Biddability, Constructability, Operability and Environmental. This project management review process incorporates a plethora of constantly changing input from USACE employees around the globe. The most current construction practices, the newest building configurations, the most recent ingenious method to perform are all captured by the USACE database to support the BCOE process. Using case studies of projects carried out at the Engineer Research and Development Center (ERDC), this paper investigates how proper utilization of the USACE’s BCOE project management process can reduce conflicts, oversights, cost over-runs, and other deleterious actions that can inversely affect the successful outcome of a project. The utilized methodology utilized encompassed three interdependent steps where the authors: (1) collected project data for five projects that were carried out in ERDC; (2) analyzed the efficiency and effectiveness of the BCOE process; and consequently (3) collected additional project data for another fifteen ERDC projects for further in-depth analysis. When properly executed, the BCOE review process was proven beneficial to ensuring the successful completion of a project through improved communication.
Educational review of Perioperative Medicine for the Junior Clinician.

• Anesthesia groups and societies have advocated for extension of anesthesiology further into the perioperative care of surgical patients for over 2 decades, often without a blueprint for the extension.
Experimental Research on Safety Distance for Live-Line Working Carried out on ±660 kV DC Power Transmission Line

The ?660 kV DC power transmission pilot project from Ningdong to Shandong is the first ?660 kV DC power transmission project in the world.Based on the engineering practice of this project,detailed experimental conditions for the research are determined,and experimental research on the safety distance for live-line working of ?660?kV DC power transmission line under various operating conditions is performed.On the basis of experiments,firstly,the overvoltage multiple occurred in ?660 kV DC power transmission line is determined by theoretical calculation;secondly,according to discharge characteristics of safety distances for various positions where the live-line working is carried out and considering the calculated overvoltage multiple,the minimum safety distance and minimum combined spacing,via which the operators enter into the equipotential working position,for ?660 kV DC power transmission line located at the area with the altitude lower than 2 000 m are calculated.Results of this research can offer reference and technical support for live-line working carried out on ?660 kV DC power transmission.
Data on the identification of protein interactors with the Evening Complex and PCH1 in Arabidopsis using tandem affinity purification and mass spectrometry (TAP-MS).

Tandem affinity purification coupled with mass spectrometry (TAP–MS) analysis is a powerful biochemical approach to identify protein–protein associations. Here we describe two datasets generated by a series of TAP–MS analyses to co-purify proteins associated with either ELF3 or ELF4 of the Evening Complex (EC) (“Identification of Evening Complex Associated Proteins in Arabidopsis by Affinity Purification and Mass Spectrometry” (Huang et al., 2016a) [1]) or proteins associated with PCH1, which is a newly identified output of the circadian clock to regulate photoperiodic growth in Arabidopsis thaliana (“PCH1 integrates circadian and light-signaling pathways to control photoperiod-responsive growth inArabidopsis” (Huang et al. 2016b) [2]). We used either ELF3, ELF4 or PCH1 fused to a C-terminal tandem affinity tag (6xHis-3xFLAG) as baits and conducted purifications in various genetic mutant backgrounds. These data are discussed in recent publications [1,2], and are deposited at the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PRIDE: PXD002606 (for EC) and PRIDE: PXD003352 (for PCH1).
In Situ High-Rate Mechanical Testing in the Dynamic Transmission Electron Microscope

It is difficult to extract details on deformation mechanisms from conventional high strain rate testing, where microstructural analysis is typically limited to before-and-after comparisons. In situ transmission electron microscopy (TEM) can provide an alternative by allowing direct observation of defect motion during loading, but thus far limitations in the speed of conventional TEM and traditional in situ straining holders have prevented the application of this technique to very high strain rates. We present the latest progress in our efforts to develop such a capability. We have developed a novel TEM specimen holder that uses piezoelectric actuators to pull a specimen in tension at rates up to 103 s−1. To fit the holder’s unique sample geometry we have developed a procedure for fabricating TEM tensile specimens with a consistent, electron-transparent gauge section. These specimens can be fabricated from bulk starting materials, allowing us to retain the materials’ original microstructure. The holder is designed to operate in the Dynamic Transmission Electron Microscope (DTEM) at Lawrence Livermore National Lab, which is capable of capturing electron images with exposure times as short as 30 ns.
Coda, or the Last Few Bars

In his Theory of the Avant-Garde, Renato Poggioli has written, ‘… the avant-garde [is] destined to perish if our civilization is condemned to perish, that is, if the world as we know it is destined to fall before a new order in which mass culture is the only form of admissible or possible culture, an order that inaugurates an uninterrupted series of totalitarian communities unable to allow a single intellectual minority of survive, unable even to conceive of exception as valid or possible.’1 Unfortunately, the current predisposition of commercial publishers indefensibly to publish material that is stylistically homogenetic tends to make Poggioli’s comments prescient. As more and more major corporations buy out more and more publishers, the tendency towards publishing textual homogeneity becomes a palpable, pageable phenomenon that is only satisfactory if it reflects the theory of ‘the bottom line.’ What this economic monopoly on style can lead to is a true sense of Entfremdung, that Marxist state of alienation in which the individual (writer in this case) has lost any bonding with a society that has misplaced its sense of the human condition as well as its own historical mission within that context. In his essay, Assembly Line Publishing, Ben H. Bagdikian writes: This conservative trend in book publishing arises from encapsulating that industry in the same economic and corporate culture that has put the whole American economy at risk. Like national economic policies, the establishmentarian bias has been pursued because it favors those with power to the disadvantage of the rest of society, including smaller enterprises. Promoted by conservative ideologues, this bias led to corporate gigantism and illiberality. The traditional big houses of the publishing world are now dominated by some of the same multinational corporations that also control other media. The new corporate owners typically cut back the size and diversity of book lists in their major imprints, not only out of greed but through some acts of monumental arrogance and stupidity about publishing.2
Economic Openness and Territorial Politics in China: Global Market Integration and Central Political Control

INTRODUCTION This chapter empirically investigates how the differential exposure to the global markets by the Chinese provinces affected the degree of political control the provincial governments incurred from the center by analyzing pooled provincial-level time-series cross-section data. As in Chapter 3, I measure the degree of economic openness of a province (that is, the degree to which a province benefits from a linkage to the global markets) with shares of exports and alternatively foreign trade in the provincial GDP. As in Chapter 4, I measure the extent of central political control exercised by the center over the provincial governments via Huang's (1996) notion of the “bureaucratic integration” of the provincial party secretaries, the top-ranking provincial officials. I find that provinces that engaged in more exports and foreign trade tended to be ruled by the more “bureaucratically integrated” provincial party secretaries predisposed to greater compliance with the policy preferences of the center during the 1978–2005 period. This lends strong empirical support to our hypothesis positing the exercise of more stringent political control over the subnational governments in those richer but more assertive winner provinces by the Chinese national leadership that rules the country via a most centralized political party. The empirical results from this chapter will make three major contributions, one to the broader study of the domestic politics of economic globalization and two to the existing research on China's central-provincial relations in the post-1978 era.
Synchronous ventricular pacing with direct capture of the atrioventricular conduction system: Functional anatomy, terminology, and challenges

Right ventricular apical pacing is associated with an increased incidence of heart failure, atrial fibrillation, and overall mortality. As a result, pacing the ventricles in a manner that closely mimics normal AV conduction with an intact His–Purkinje system has been explored. Recently, the sustainable benefits of selective His-bundle stimulation have been demonstrated and proposed as the preferred method of ventricular stimulation for appropriate patients. Ideally, conduction system pacing should be selective without myocardial capture, overcome distal bundle branch block when present, and not compromise tricuspid valve function. Contemporary literature on conduction system pacing is confusing largely because of inconsistent terminology and, at times, anatomically inaccurate terms used interchangeably for nonsynonymous anatomic sites. In this review, we discuss the functional anatomy of AV conduction access with specific emphasis on terminology, relationship to the membranous septum, tricuspid valve tissue, and proximity to atrial or ventricular myocardium. The potential benefits of each specific site as well as associated unique difficulties with those sites are described.
IMPACT OF GLUCOSE MANAGEMENT TEAM ON OUTCOMES OF HOSPITALIZARON IN PATIENTS WITH TYPE 2 DIABETES ADMITTED TO THE MEDICAL SERVICE

Objective: To improve glycemic control of hospitalized patients with diabetes and hyperglycemia, many medical centers have established dedicated glucose management teams (GMTs). However, the impact of these specialized teams on clinical outcomes has not been evaluated. Methods: We conducted a retrospective study of 440 patients with type 2 diabetes admitted to the medical service for cardiac or infection-related diagnosis. The primary endpoint was a composite outcome of several well-recognized markers of morbidity, consisting of: death during hospitalization, transfer to intensive care unit, initiation of enteral or parenteral nutrition, line infection, new in-hospital infection or infection lasting more than 20 days of hospitalization, deep venous thrombosis or pulmonary embolism, rise in plasma creatinine, and hospital re-admissions. Results: Medical housestaff managed the glycemia in 79% of patients (usual care group), while the GMT managed the glycemia in 21% of patients (GMT group). The primary outco...
TCT-704 Mitral Annular Calcification Does Not Impact MitraClip Procedural Success and Is Not Associated with Durability of Repair

Mitral annular calcification (MAC) has been associated with coronary atherosclerosis and increased mortality. While patients (pts) undergoing percutaneous edge-to-edge repair of mitral regurgitation (MR) often have significant MAC, the impact of MAC on procedural success and durability of repair is
Reproducibility and stability of severe asthma research program (SARP) clinical cluster phenotypes in SARP3

Background: The SARP1/2 cluster analysis identified 5 clinical asthma phenotypes that reflect inflammatory mechanisms: a spectrum of early onset allergic asthma (Clusters 1,2,4), late onset severe asthma (Cluster 3) and severe asthma with COPD characteristics (Cluster 5). Aims: Evaluate reproducibility and stability of SARP1/2 clinical cluster phenotypes in SARP3, a 3-year longitudinal cohort enriched for severe asthma. Methods: SARP3 subjects > 12 years old (n= 594) were assigned to SARP1/2 clusters using 11 variables and compared to the SARP1/2 cohort (n=1176). Subjects in both SARP1/2 and SARP3 (n=68) were assigned to clusters twice using unique SARP1/2 and 3 data. Results: The SARP3 cohort is skewed toward severe asthma clusters 3(16%), 4(15%) and 5(19%). SARP3 subjects are older with longer disease duration (p Conclusions: All five SARP1/2 clinical cluster phenotypes are reproducible in SARP3 with a shift toward more severe clusters (3,4,5). In a subset of SARP subjects with longitudinal data there was heterogeneity in the progression of disease severity that was associated with changes in baseline lung function. These results suggest that a clinical approach guided by monitoring of lung function could identify patients at risk for disease progression.
Targeting Innate-Like T Cells in Tuberculosis

Peptide-specific conventional T cells have been major targets for designing most antimycobacterial vaccines. Immune responses mediated by conventional T cells exhibit a delayed onset upon primary infection and are highly variable in different human populations. In contrast, innate-like T cells quickly respond to pathogens and display effector functions without undergoing extensive clonal expansion. Specifically, the activation of innate-like T cells depends on the promiscuous interaction of highly conserved antigen-presenting molecules, non-peptidic antigens, and likely semi-invariant T cell receptors. In antimicrobial immune responses, mucosal-associated invariant T cells are activated by riboflavin precursor metabolites presented by major histocompatibility complex-related protein I, while lipid-specific T cells including natural killer T cells are activated by lipid metabolites presented by CD1 proteins. Multiple innate-like T cell subsets have been shown to be protective or responsive in mycobacterial infections. Through rapid cytokine secretion, innate-like T cells function in early defense and memory response, offering novel advantages over conventional T cells in the design of anti-tuberculosis strategies.
Abstract 175: Development of a National Dataset for Ambulatory Quality Improvement and Research: Insight From The Guideline AdvantageTM

Background: Electronic Health Record (EHR) data provides a wealth of patient data valuable to providers, organizations, registries, and researchers. The Guideline Advantage™ (TGA) has been developed by the American Heart Association, American Cancer Society, and American Diabetes Association as a national ambulatory registry to cover primary and secondary prevention across multiple disease groups. Methods: The program leverages EHR data to populate a clinical registry and provide population health measurement and analytic tools to drive improvements in population health and support registry-based research. TGA uses a data extraction model without the restrictions and resource demands of traditional data abstraction or interface mechanisms typical of clinical registries. This model supports customization and flexibility in data alignment which allows for more accurate measurement and representation of the care being delivered. The web-based population health tool delivers a clear lens into clinical data from a population level to a patient level, simplifying data stewardship and improvement tracking. Through these methods, the program has grown to include 25,091,500 patient observations for 797,079 unique patients. 408 providers and their clinical teams have access to population health analytic tools, quality improvement support, and resources to drive improvements in the care they are delivering. Discussion: While there are several disease-specific registries in existence, there have not yet been integrated solutions that can expand across key chronic and acute conditions facing ambulatory patients. To obtain data across multiple conditions without a high resource burden, TGA is maintaining a data extract model that foregoes traditional barriers and resource burdens such as extensive query development, abstraction, or maintaining costly interfaces. The data extraction model affords the ability to obtain exponentially more data than abstraction models allowing the registry to cover multiple disease groups. This breadth of data improves the application of the registry in both the practice setting and research. With this data, practices are able to look across their entire population to identify high-risk or at-risk populations with a single condition or comorbid conditions and create cohorts of patients to target with quality improvement strategies. Providing clinicians and researchers a clear look into complete and longitudinal clinical data is critical to supporting quality improvement activities pivotal to success in value-based care models and the advancement of novel research in primary and secondary prevention.
Mesial Temporal Lobe Sclerosis

Mesial temporal sclerosis is the most common cause of temporal lobe epilepsy. The combination of anatomic and functional information with PET/MR imaging precisely localizes the seizure focus.
Ten Years of the Agile Software Factory for Software Engineering Education and Training

The Agile Software Factory (ASF) was created in the Department of Computer Science at Bowling Green State University nearly ten years ago to promote the use of agile methods, improve student education through service-learning opportunities, and to facilitate community engagement by handling the many software requests that regularly arrive in the department. In pursuit of these goals, the ASF has had many successes and faced challenges in a variety of areas. This paper describes the history of the ASF along with the multiple successes and challenges that it has faced over the years. Future plans to continue fulfilling the educational mission of the ASF while widening its impact are also discussed, including the creation of a student mentorship program, promoting software engineering research, and sponsoring software engineering related events.
A Study of Chinese-American Elderly Residing in Hotel Rooms:

A study of elderly Chinese-American residents in the Chinatown area of Los Angeles reveals hidden poverty, loneliness, language barriers, physical isolation, a sense of familial dislocation, and a ...
Nanocavity Design for Reduced Spectral Diffusion of Solid-State Defects

We report on the reduced spectral diffusion of nitrogen vacancy centers in waveguides and cavities. We also design a cavity that provides both high quality factor and isolation from diamond surfaces.
Anesthesia for Tracheal Surgery

Tracheal resection and reconstructive surgeries are advanced procedures that require coordination and communication between anesthesiology and surgical teams. Common causes for resection include trauma, subglottic stenosis from prolonged intubation, tracheal masses and congenital causes. A thorough preoperative evaluation including pulmonary function distal to the stenotic portion of trachea is essential. A safe plan to initially secure the airway can be a challenge and the option of an elective awake tracheostomy should be considered. Total intravenous anesthesia should be considered to avoid pollution of the operating room and provide consistent anesthetic delivery. Extubation considerations include ensuring adequate ventilation and avoidance of stimulation, coughing or bucking which can catastrophically disrupt the new tracheal suture lines. Table 13.2, summarizes the anesthetic considerations in patents undergoing tracheal surgery.
Nonlinear Vibrational Spectroscopy

Second order nonlinear spectroscopies such as sum frequency generation (SFG) are intrinsically interface sensitive and enable sub-monolayer sensitivity to be achieved at buried, optically accessible interfaces. Vibrationally-resonant SFG allows bond (functional group) selective in-situ spectroscopy of interfaces as diverse as solid-solid, liquid-liquid and liquid-gas. This chapter summarizes the theoretical underpinnings of vibrationally-resonant SFG and its practical implementation.
Fixed action patterns and neural Darwinism

The stereotopy of the “Fixed Action Pattern” of classical ethology is customarily attributed to “hard wiring”. We submit that this explanation is akin to the 17th century use of the homunculus to explain development. We propose extendingEdelman's notions of neural Darwinism to explain the emergence of species-characteristic (“innate”) motor patterns.
Enzymes of Sterol Biosynthesis

Publisher Summary This chapter discusses several aspects of the enzymology of sterol biosynthesis. The first two steps in the enzymic approach require investigation of particle-bound enzymes to establish the presence of the enzyme and to investigate the principal characteristics of the particulate enzyme. Direct extraction of enzyme from particles into dilute buffer should be tried first because this method eliminates the complicating effect of detergents or other solubilizing agents. These latter substances must be removed to achieve criteria of solubility, and removal may be extremely difficult. Extraction efficacy may be improved by desiccating the microsomes first, either by lyophilization or extraction with anhydrous solvent. Although partial proteolysis was one of the first methods used to obtain soluble enzymes from microsomes, the method has a severe disadvantage that alteration of the sought-for enzyme may occur during liberation from particles. Limiting use of the procedure to removal of unwanted protein prior to liberation of the sought-for enzyme with another procedure seems to be a more reasonable use of the digestion techniques.
REHABILITATION DESIGN AND EVALUATION OF THE HAWTHORNE STREET BRIDGE FRP DECK INSTALLATION

ABSTRACT The Hawthorne Street Bridge is a 75' clear span historic through truss structure over a C&O Railroad/CSX Rail line. There are five 15' bays transversely supported by W14x119 girders. Stringers (W10x33) on 5' centers support the 6-inch thick reinforced concrete deck between girders. The bridge is presently posted at 7 tons with a recommendation to reduce to 5 tons based on a recent load rating. VDOT and the City of Covington desire to upgrade the Hawthorne St. Bridge. The reinforced concrete (RC) deck is in poor condition and recently has been patched after several large pieces of deck fell onto the railroad tracks to the extent that the City closed the structure in February of 2001 to make emergency repairs. In addition, there is a concrete sidewalk that requires rehabilitation and whose weight is critical in the rating of the structure. The proposed rehabilitation would retain the historic cast iron Phoenix truss system while replacing the RC deck, floor beams and stringers. A deck constructed from adhesively bonded pultrusions is presently suggested reducing the dead load from 100 lb/ft2 to 25 lb/ft2. Both one and two-way bending analysis of the deck stringer configuration, not including composite action, has been accomplished and validated via scaled model testing. In addition to the bolted connection between the deck and stringers developed for the design, an adhesively bonded condition is also being considered and tested. The details of the design and analysis are presented in conjunction with cost and installation considerations.
FCM immunophenotyping and DNA analysis: Practical aspects that can affect data analysis and interpretation

In the optimal setting, the FCM lymphoma-leukemia immunophenotyping laboratory is an integral component of the diagnostic hematopathology service. Flow cytometric analysis involves three stages: preanalytical (specimen handling and processing, including antibody staining), analytical (running the sample through the flow cytometer and acquiring data), and postanalytical (data analysis and interpretation). The quality and performance of the preanalytical and analytical steps impact on the resulting fluorescence data and thereby the interpretation. Deficiencies such as suboptimal instrument performance, poor reagent quality (antibodies and/or fluorochromes), or poor specimen quality can all result in inadequate resolution of positive and negative immunofluorescence.
IT-Driven Organizational Identity Change: A Longitudinal Inquiry

While organizational scholars are increasingly interested in issues of identity, in-depth empirical studies analyzing the actual process of identity change have lagged, particularly when the process is triggered by IT-related transformational change (Alvesson et al. 2008). In this longitudinal case study, we follow the identity change process of librarians following the digitization of their work environment. We use segments of Hatch & Schultz’s (2002) organizational identity dynamics model to uncover the provisional identities experienced by librarians over time. We also illustrate how the librarians’ image, as mirrored by the patrons, led the librarians to put forward initiatives to impress on the patrons ideas of “who they were” and “who they could be.” This duality is explained by the ambiguous nature of information technology, which can be interpreted as both an opportunity and a threat concurrently.
IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma.

The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-s has an unclear role in metastases formation. In order to understand the role of IL23, an interleukin associated with macrophage polarization, we investigated IL23 in the context of TGF-s expression in PDAC. We hypothesized that IL23 expression is associated with metastatic development and survival in PDAC. We investigated IL23 and TGF-s protein expression on resected PDAC patient tumor sections who were divided into short-term ( 30 months) survivors. Panc-1 cells treated with IL23, TGF-s, macrophages, or combinations thereof, were orthotopically implanted into NSG mice. Patients in the long-term survivor group had higher IL23 protein expression (P = 0.01). IL23 expression was linearly correlated with TGF-s expression in patients in the short-term survivor group (P = 0.038). Macrophages induce a higher rate of PDAC metastasis in the mouse model (P = 0.02), which is abrogated by IL23 and TGF-s treatment (P < 0.001). Macrophages serve a critical role in PDAC tumor growth and metastasis. TGF-s contributes to a less tumorigenic TME through regulation of macrophages. Macrophages increases PDAC primary tumor growth and metastases formation while combined IL23 and TGF-s pre-treatment diminishes these processes.
Self-motion processing in visual and entorhinal cortices: inputs, integration, and implications for position coding.

The sensory signals generated by self-motion are complex and multimodal, but the ability to integrate these signals into a unified self-motion percept to guide navigation is essential for animal su...
Do Orthostatic Vital Signs Have Utility in the Evaluation of Syncope

Abstract Background Syncope is a common presentation in the emergency department (ED). The differential diagnosis is long and includes benign conditions as well as acute life threats, such as dysrhythmias or pulmonary embolism. Objective The specific goals of this review are twofold: 1) to define the diagnostic utility of orthostatic vital signs (OVS) as a test for orthostatic syncope, and 2) to determine whether OVS help diagnose or exclude life-threatening causes of syncope in ED patients. Methods Three prospective cohort studies plus 2017 national guidelines for syncope management were identified, reviewed, and critically appraised. Results This literature review found that orthostatic hypotension is common among ED patients with syncope and is often diagnosed as the cause of syncope. Conclusions OVS measurements do not, in isolation, reliably diagnose or exclude orthostatic syncope, nor do they appear to have value in ruling out life-threatening causes of syncope.
Introduction: Philosophers and Public Policy

This chapter provides an introduction to the Palgrave Handbook of Philosophy and Public Policy. It begins by discussing the many ways that philosophical reasoning can fruitfully be brought to bear on matters of public policy, providing examples in each case that are drawn from the volume. This includes different kinds of contributions philosophers can make (helping us think more carefully and critically about abstract and general moral principles that are relevant to public policy decisions, arguing for a particular position on a particular issue, or against a particular position, or against a particular argument, or simply clarifying the nature of the considerations on both sides of a debate) and different kinds of methods they can use when making them (arguing from a particular theory, arguing from a pluralistic set of theories, or arguing from particular cases). The chapter then provides a sequential overview of all the entries in the volume, broken down into eight parts, and concludes by emphasizing that the work as a whole should be viewed as something like a snapshot of the field rather than as a fully comprehensive and representative survey.
Short-Term Load Forecasting With Different Aggregation Strategies

Effective short-term load forecasting (STLF) plays an important role in demand-side management and power system operations. In this paper, STLF with three aggregation strategies are developed, which are information aggregation (IA), model aggregation (MA), and hierarchy aggregation (HA). The IA, MA, and HA strategies aggregate inputs, models, and forecasts, respectively, at different stages in the forecasting process. To verify the effectiveness of the three aggregation STLF, a set of 10 models based on 4 machine learning algorithms, i.e., artificial neural network, support vector machine, gradient boosting machine, and random forest, are developed in each aggregation group to predict 1-hour-ahead load. Case studies based on 2-year of university campus data with 13 individual buildings showed that: (a) STLF with three aggregation strategies improves forecasting accuracy, compared with benchmarks without aggregation; (b) STLF-IA consistently presents superior behavior than STLF based on weather data and STLF based on individual load data; (c) MA reduces the occurrence of unsatisfactory single-algorithm STLF models, therefore enhancing the STLF robustness; (d) STLF-HA produces the most accurate forecasts in distinctive load pattern scenarios due to calendar effects.Copyright © 2018 by ASME