cssi/SciSciGPT-SciSciNet huggingface dataset:
Correction of deformity and prevention of aseptic necrosis in late cases of slipped femoral epiphysis.

1. The object of treatment of slipped or slipping capital femoral epiphsysis is to maintain or restore painless hip function, with a range of motiots as nearly normal as possible and a minimum of shortening of the extremity. 2. Epiphysiolysis with marked displacement has been treated by open wedge osteotomy with uniformly good results. Aseptic necrosis with osteo-arthritis occurs rarely. The incidence is definitely less than that which follows closed manipulation, and is no greater than that which follows application of a cast without any attempt at reduction. 3. An accurate determination of the degree of slipping is essential. This is possible only with good lateral roentgenograms of the hip. 4. To avoid aseptic necrosis or delayed osteo-arthritis, there must be a minimal amount of damage to the blood supply when the capsule is opened to expose the joint. 5. Wedge resection of the proximal superior portion of the femoral neck should he followed by gentle freeing of the head, just distal to the epiphyseal line. 6. The epiphsyseal plate must be perforated with a gouge and a curette, thus exposing porous cancellous hone on the portion of the head which will be in contact with the prepared neck surface. 7. Great care should be exercised in the reduction to prevent additional injury to the cir(culation of the femoral head, as a result. of needless stretching or tearing of the ligamentum teres or the capsular vessels. The head should be placed in position over the raw bone surface on the top of the neck. 8. Rigid intetnal fixation of the head of the femur to the neck is essential. 9. Early active motion is most desirable, with the hip Protected from weight-bearing until healing is complete. 10. If the follow-up roentgenograms show aseptic necrosis, weight-bearing should be postponed until there is roentgenographic evidence of replacement of the dead bone by creeping substitution.
GM-CSF: a double dose of protection during pneumonia

invading microbes are rapidly recognized in the lower respiratory tract, resulting in robust and often dangerous immune responses. The degree to which innate immunity is launched and maintained largely depends on gene expression programs controlled by pattern recognition receptors and
7. The Life Cycle of the Diptera

In attempting a summary such as this one is almost dismayed by the great gaps in our knowledge of even the commonest species. Doubtless many of the gaps in what follows could be filled by a more careful scrutiny of the literature; many more, I am sure, could be filled from unpublished records and observations of the members of this Society; but when all this is recorded we shall find that very much more investigation must be performed before we can so much as give a comprehensive statement for all the species of a single family or for a single species of each family.
Gender Differences in Conceptualizations of STEM Career Interest: Complementary Perspectives from Data Mining, Multivariate Data Analysis and Multidimensional Scaling.

Data gathered from 325 middle school students in four U.S. states indicate that both male (p < .0005, RSQ = .33) and female (p < .0005, RSQ = .36) career aspirations for being a scientist are predictable based on knowledge of dispositions toward mathematics, science and engineering, plus self-reported creative tendencies. For males, strong predictors are creative tendencies (beta = .348) and dispositions toward science (beta = .326), while dispositions toward mathematics is a weaker (beta = .137) but still significant (p < .05) predictor. For females, significant (p < .05) predictors ordered by strength of contribution are dispositions toward science (beta = .360), creative tendencies (beta = .253) and dispositions toward mathematics (beta = .200). Additional analyses indicate that engineering appears to be more closely aligned with STEM career aspirations for females than for males. These findings contribute to the growing body of knowledge indicating that at the middle school level major contributors to choosing a path toward a STEM career differ for boys versus girls.
Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.

Background Uterine fibroids are a significant health problem. These common benign tumors occur in 70–80% of women before age 50 years and often cause bleeding and pain and can interfere considerably with daily life. Current treatment options are limited. Fibroids contain substantial amounts of altered and disordered collagens, which contribute to their bulk. Targeting these collagens directly presents a novel treatment approach. Objectives We sought to test the hypothesis that a highly purified collagenase Clostridium histolyticum will digest interstitial collagen in uterine fibroids and reduce their stiffness and thereby evaluate the feasibility that this collagenase C histolyticum can be developed into an alternative treatment for fibroids. A secondary objective was to describe the collagen content of the fibroid tissue. Study Design Fibroid tissue cubes (1 cm 3 ; n = 154) were cut from 17 uterine fibroids that were obtained from 7 consented subjects undergoing scheduled hysterectomies. Tissue cubes were injected with diluent, placebo, or highly purified collagenase C histolyticum (0.05, 0.1, or 0.2 mg/cube) and incubated at 37°C for 24, 48, 72, or 96 hours. At each time point, 6 noninjected control cubes were also evaluated. Tissue cubes were photographed before and after incubation. Myometrial samples (n = 21) were also evaluated. Stiffness was quantified through rheometry by measuring complex shear moduli of the tissues. Percent fibrosis was determined by computerized analysis of Masson-trichrome–stained slides. Digestion of collagen fibrils was confirmed by transmission electron microscopy. Results Fibrosis in untreated fibroids ranged from 37% to 77%, reflecting the collagen-rich nature of these tumors. After treatment with collagenase for 96 hours, fibrosis ranged from 5.3% to 2.4%. Transmission electron microscopy confirmed complete digestion of collagen fibrils. Tissue stiffness was reduced with all 3 doses of collagenase treatment and at all 4 time points. Longer incubation times with collagenase caused greater reduction in stiffness, and treated cubes lost their cuboidal shape and had gelatinous/liquefied centers. At 96 hours the stiffness in tissues treated with the lowest dose was reduced to 966 ± 106 Pascal compared with the diluent-treated control at the same time (5323 ± 903 Pascal; P Conclusion Uterine fibroids have a high content of collagen that can be effectively digested by highly purified collagenase C histolyticum , resulting in reduced tissue stiffness. Loss of stiffness may decrease bulk symptoms in vivo and possibly lead to shrinkage of fibroids through changed mechanotransduction, leading ultimately to reduced fibroid symptoms of pain and bleeding. Clinical trials are necessary to evaluate the safety and efficacy of collagenase C histolyticum including the rate of regrowth of fibroids. The data of this study provide a strong rationale for using this purified collagenase in clinical trials as a local treatment for women with fibroids.
Building High QoS Backhaul of WCDMA Network with PTN

It presents the means on building high QoS backhaul of WCDMA network by using Diff- Serv QoS mechanism of PTN,gives QoS policy for different WCDMA network services to provide reference for the carriers.
Analyzing the Quality of Monitoring in Nursery Disinfection in Gaoming District of Foshan from 2008 to 2012

OBJECTIVE To learn the nursery disinfection quality and health status,to explore improve the quality of nursery disinfection quality in Gaoming District.METHOD A retrospective survey methods was used to analysis the data from nursery disinfection monitoring system in Gaoming District from 2008 to 2012.RESULTS In 5 886 sampling,the average compliance rate is 67.99%.The compliance rate for five consecutive years were 75.67%,66.59%,59.07%,66.55%and 74.93%.The compliance rate of nursery indoor air hygiene is 81.86%,kitchenware was 88.72%,while toys,tabletops,bed and other surfaces were 69.96%.Children and teachers were 50.88%.Compare to city center(73.05%),the compliance rate in town was 58.41%.The compliance rate of kindergartens and nurseries were 69.89%and 55.48%.CONCLUSIONS The overall compliance rate of Nurseries disinfect is low.Among the monitoring project,the compliance rate of children and teacher as low.Hand disinfection issues should arouse attention.On the other side,urban is higher than the town,kindergartens are higher than nurseries.Relevant departments should take intervention measures to strengthen disinfection knowledge,skills,training and supervision.
CNS DRUG DISCOVERY IN THE 21ST CENTURY : FROM GENOMICS TO COMBINATORIAL CHEMISTRY AND BACK

The discovery of new drugs for psychiatric and neurological disorders has been greatly facilitated by advances in molecular biology, genetics and chemistry. Several examples are given of how these revolutionary advances have been applied to the discovery of new drugs that selectively modify serotonergic neurotransmission, including compounds which may prove to be more effective antidepressants.
Entering the 21st Century: Water Quality Issues River Basin Management

Water quality issues have developed primarily in the 20th century in the United States of America. Historically, the emphasis has been placed upon the protection of human health with the states and local units of government having responsibility for ensuring implementation of programs and activities to provide for maintenance of public health needs. In 1948, legislation established an active role for the federal government in the provision of water quality and protection of public health. In 1972, the federal government initiated a vigorous program aimed to limit both industrial and municipal point source discharges, provide for control of toxics, set discharge limits, and provide adequate federal funding to assist governmental units to meet the stringent requirements established by the legislation. New perspectives and new realities require farsighted and innovative means to address water quality issues in the 21st century.
Magnetic Shielding Effect of Bi(Pb)2Sr2Ca2Cu3O8 Superconductor Prepared by Hot-Forging

Highly oriented Bi(Pb)2Sr2Ca2Cu3O8 superconductor plates were prepared by hot-forging for magnetic shielding. The forging was carried out at 750°C–860°C and 100–1000 MPa in air. The orientation factor was estimated to be 0.97 with the c-axis parallel to the pressing direction, from the X-ray diffraction pattern. This orientation factor gave the highest critical current density, Jc = 31,800 A/cm2 (77K, 0T). The prepared plate shielded magnetic field up to 90 gauss. The magnetic shielding effect depended on Jc and the sample homogeneity. The results might be explained by the critical state model.
How advances in technology keep reducing interventionist policy rationales

Abstract Rationales for government interventions in the market are typically based on theories of market failure set within a framework of fixed private-sector practices and technologies. However, continuous technological progress and entrepreneurial innovation are eroding the theoretical foundations of these policies, making them increasingly obsolete. This paper describes the four pillars of market failure doctrine and provides examples of how the market is using technology to solve problems previously considered to necessitate government intervention.
Web accessibility guidelines for the 2020s

W3C has completed the 2.0 versions of its three web accessibility guidelines addressing authoring, content, and user agents. It now is working to address new needs created by ongoing evolution of the Web. Using a user needs-focused approach it is developing technologies, techniques, and guidelines to make the Web accessible to people with disabilities.
The Microwave Radiometer Working Group [Technical Committees]

The IEEE Geoscience and Remote Sensing Society (GRSS) Instrumentation and Future Technologies Technical Committee (IFT-TC) seeks to foster international cooperation to advance the state of the art in geoscience and remote sensing instrumentation and technologies that improve knowledge for the betterment of society and the global environment. The mission of the IFT-TC is to facilitate, engage, and coordinate GRSS members and communities at large to assess the current state of the art in remote sensing instruments and technology, identify new instrument concepts and relevant technology trends, and recognize enabling technologies for future instruments.
Bad Economics, Good Law: The Concept of Externality

The term “externality” is pervasive in modern economics. Most microeconomic theory textbooks have a chapter devoted to the topic as do texts covering public economics. This chapter argues that law deals with the matter of externality in an economically efficient manner. Courts largely ignore the term externality despite its common use in economics and, more importantly, law has changed little to incorporate the now-common economic meaning of externality. Law, especially tort law, often deals with what economists would call relevant externalities. Economists often fail to understand what constitutes a relevant externality, resulting in the term being operationally meaningless.
ADAPTABILITY OF POTATO DRYING TO YAM PROCESSING1

One of the problems related to the food supply in Nigeria and other West African countries at present is that of efficient preservation and processing of raw products. In this brief review of potato processing techniques, properties of West African yams are compared with those of potato with a view to explore possibilities of adapting potato processing techniques to yams. Yams referred to in this article are of the family Dioscoreaceae, and they are different from the yams known in the U.S.A. The American yams are of the family Convovulaceae and are a variety of sweet potatoes. Possible new foods from West African yams, similar to convenience foods made from potato are also proposed. Of the varieties of yam grown in Nigeria, Dioscorea alata (water yam) is compositionally closest to potato. Properties of other varieties also are comparable to those of potato. Because there are similarities between the two tuberous crops, various methods for dehydrating potato could be adapted to drying of the West African yam.
The Determinants and Consequences of District Partisan Change and Intactness in the Congressional Redistricting Process: An Integrative Model

In this study of redistricting from 1992 to 2012, we develop an integrative path analysis model that links together the two parts of the congressional redistricting process: the impact of political and environmental antecedent variables on district partisan change and constituency intactness, and the subsequent impact that partisan chance and intactness have on incumbent reelection margin. Environmental factors, most notably the extent of a district’s overor under-population prior to redistricting, are found to ultimately make more difference on safety than does party control of the redistricting plan. Furthermore, the pathways extending through partisan change are more important for members’ reelection margin than are the pathways extending through intactness. Since members typically end up with a sizable share of new constituents, however, whereas a fairly even balance exists between districts left with pro-incumbent or anti-incumbent partisan change, the average member actually has somewhat more to fear from the former product of the redistricting process.
Etonogestrel contraceptive implant-associated secondary anorgasmia.

Abstract The etonogestrel contraceptive implant is a 4-cm radio-opaque subdermal rod, inserted in the nondominant arm, providing up to 3 years of continuous contraception. We describe a 21-year-old nulligravid, nondepressed female who experienced new-onset secondary anorgasmia 1 month after etonogestrel insertion. Off-label, oral use of bupropion and sildenafil did not restore orgasmic ability. Finally, 1 week after implant removal (4½ months after insertion), spontaneous return of orgasmic ability occurred. Anorgasmia after etonogestrel implant use is a rare adverse event; nonetheless, clinicians should be alert to its possibility. Implication statement This report documents secondary anorgasmia in a nondepressed female temporally associated with etonogestrel implant insertion. Clinicians should be aware that this rare event can occur but is quickly reversible with implant removal.
Material Needs of Emergency Department Patients: A Systematic Review.

Background Interest in social determinants of health (SDOH) has expanded in recent years, driven by a recognition that such factors may influence health outcomes, services use, and health care costs. One subset of SDOH is material needs such as housing and food. We conducted a systematic review of the literature on material needs among emergency department (ED) patients in the United States. Methods We followed PRISMA guidelines for systematic review methodology. With the assistance of a research librarian, four databases were searched for studies examining material needs among ED patients. Two reviewers independently screened titles, abstracts, and full text to identify eligible articles. Information was abstracted systematically from eligible articles. Results Forty-three articles were eligible for inclusion. There was heterogeneity in study methods; single-center, cross-sectional studies were most common. Specific material needs examined included homelessness, poverty, housing insecurity, housing quality, food insecurity, unemployment, difficulty paying for health care, and difficulty affording basic expenses. Studies overwhelmingly supported the notion that ED patients have a high prevalence of a number of material needs. Conclusions Despite some limitations in the individual studies examined in this review, the plurality of prior research confirms that the ED serves a vulnerable population with high rates of material needs. Future research is needed to better understand the role these needs play for ED patients and how to best address them.
Validity of the Red Reflex Exam in the Newborn Eye Screening Test Cohort.

Background and objective The validity of the red reflex exam has yet to be tested against new methods of wide-angle imaging that may improve early detection of neonatal ocular pathology. The authors aimed to determine the validity of the pediatrician's red reflex exam using 130° wide-angle external and fundus digital imaging as a gold standard. Patients and methods This was a prospective cohort study of 194 healthy, term newborns enrolled in the Newborn Eye Screening Test study at Lucile Packard Children's Hospital from July 25, 2013, to July 25, 2014. Red reflex screening was performed by a pediatrician in the newborn nursery and wide-angle fundus digital imaging was performed by a neonatal intensive care unit-certified nurse. The main outcome measure was the validity of the pediatrician's red reflex exam (unweighted kappa [κ] statistic, sensitivity, specificity). Results Compared to no subjects with abnormal red reflex exams reported in the pediatrician's notes, 49 subjects demonstrated one or multiple ocular abnormalities on 130° wide-angle fundus imaging (κ = 0.00). The pediatrician's red reflex exam had a sensitivity of 0.0% (95% CI, 0.0%-7.3%) and specificity of 100.0% (95% CI, 97.5%-100.0%) for the detection of ocular abnormalities. Conclusion This study demonstrates the ability of wide-angle fundus imaging to detect fundus abnormalities not otherwise identified by standard newborn red reflex screening prior to hospital discharge. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:103-110.].
Environmental impact of biogas: A short review of current knowledge

The social acceptance of biogas is often hampered by environmental and health concerns. In this study, the current knowledge about the impact of biogas technology is presented and discussed. The survey reports the emission rate estimates of the main greenhouse gases (GHG), namely CO2, CH4 and N2O, according to several case studies conducted over the world. Direct emissions of gaseous pollutants are then discussed, with a focus on nitrogen oxides (NOx); evidences of the importance of suitable biomass and digestate storages are also reported. The current knowledge on the environmental impact induced by final use of digestate is critically discussed, considering both soil fertility and nitrogen release into atmosphere and groundwater; several case studies are reported, showing the importance of NH3 emissions with regards to secondary aerosol formation. The biogas upgrading to biomethane is also included in the study: with this regard, the methane slip in the off-gas can significantly reduce the environmental benefits.
SNAP: Strong Scaling High Fidelity Molecular Dynamics Simulations on Leadership-Class Computing Platforms

The rapidly improving compute capability of contemporary processors and accelerators is providing the opportunity for significant increases in the accuracy and fidelity of scientific calculations. In this paper we present performance studies of a new molecular dynamics MD potential called SNAP. The SNAP potential has shown great promise in accurately reproducing physics and chemistry not described by simpler potentials. We have developed new algorithms to exploit high single-node concurrency provided by three different classes of machine: the Titan GPU-based system operated by Oak Ridge National Laboratory, the combined Sequoia and Vulcan BlueGene/Q machines located at Lawrence Livermore National Laboratory, and the large-scale Intel Sandy Bridge system, Chama, located at Sandia. Our analysis focuses on strong scaling experiments with approximately 246,000 atoms over the range 1-122,880 nodes on Sequoia/Vulcan and 40-18,630 nodes on Titan. We compare these machine in terms of both simulation rate and power efficiency. We find that node performance correlates with power consumption across the range of machines, except for the case of extreme strong scaling, where more powerful compute nodes show greater efficiency. This study is a unique assessment of a challenging, scientifically relevant calculation running on several of the world's leading contemporary production supercomputing platforms.
EXPERT: a system for developing consultation models

EXPERT Is a system for designing and building models for consultation. An EXPERT model consists of hypotheses (which can be structured Into causal and taxonomic networks); findings or observations; and decision rules for logically relating these components. A relatively simple language for describing models is employed. Logical and probabilistic rules are restricted to particular types which implicitly order the tasks performed by the control strategies: classification, question selection, and explanation. Explicit representations of decision rules are emphasized, as opposed to suboptimal scoring functions. This results in more easily predictable and correctable performance for a model. The system is currently being used to develop consultation models in domains such as rheumatology, ophthalmology, and endocrinology.
THYROID STORM WITH COMA IN A PATIENT WITH METASTATIC THYROID CARCINOMA AND GRAVES DISEASE: WON THE BATTLE BUT LOST THE WAR.

ABSTRACT Objective: To describe the background and events that may precipitate thyroid storm (TS) with coma as well as the course of treatment intervention and our patient's response to treatment. ...
Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation.

Abstract Background African Americans (AA) are disproportionately impacted by atopic dermatitis (AD), with increased prevalence and therapeutic challenges unique to this population. Molecular profiling data informing development of targeted therapeutics for AD are derived primarily from European American (EA) patients. These studies are absent in AA, hindering development of effective treatments for this population. Objective We sought to characterize the global molecular profile of AD in the skin of AA patients as compared with that of EA AD and healthy controls. Methods We performed RNA-Seq with reverse transcription polymerase chain reaction validation and immunohistochemistry studies in lesional and nonlesional skin of AA and EA AD patients vs healthy controls. Results African American AD lesions were characterized by greater infiltration of dendritic cells (DCs) marked by the high-affinity immunoglobulin E (IgE) receptor (FceR1+) compared with EA AD (P Conclusion The molecular phenotype of AA AD skin is characterized by attenuated Th1 and Th17 but similar Th2/Th22-skewing to EA AD. Our data encourages a personalized medicine approach accounting for phenotype-specific characteristics in future development of targeted therapeutics and clinical trial design for AD.
The Challenges of Writing in School: Conceptualizing Writing Development Within a Sociocognitive Framework

This article argues for a conceptualization of school writing that emphasizes how cognitive and sociocultural factors interact. In academic, professional, and affinity-based communities, an emphasi...
Artificial intelligence approaches for modeling social terrain

Advanced technologies are transforming the information environment and allowing individuals and groups unprecedented opportunities to share ideas, actions, emotions, conflicts, and activities. While this enables social groups to expand their membership in the global online community, it also allows scientists to use the social media environment as a real-world laboratory to study emerging behaviors in this space. For military analysts, this environmental laboratory provides an opportunity to study communities in advance of deployments to foreign soil. In the same way that military logisticians would study physical terrain to plan for equipment, analysts can observe activities in the information environment to plan for negotiations in the social terrain. This presentation will discuss key concepts for modeling the social terrain and will identify promising AI techniques for each. Key concepts will include Human, Information, Interpretation, and Influence considerations. AI technologies will be discussed for each of the following social terrain considerations: Human, Information, Interpretation, and Influence. Together, these elements form the underpinning science of sensemaking within the new information environment. The Human Systems Community of Interest (HS COI) within the US Department of Defense (US DOD) is exploring how to jointly establish effective capabilities in this sphere for rapid exploitation at the tactical operational levels. This paper will address the priorities and future needs of this Joint research effort and will explore technical challenges that face the transition of research results to system-level applications.
Addressing Cultural Challenges of Teaching English to Chinese Students for Beginning ESL Instructors

Teaching English to students from an Asian cultural background presents unique challenges. This article uses the author’s experience of studying and teaching in China and working with Asian students in a multicultural context in the USA to identify persistent challenges, share the reasons that she believes are behind these challenges and offer practical solutions that instructors can use in their classroom today. Although the focus is primarily on Chinese students, the information might also be useful for ESL teachers working with other Asian learners. This article brings to attention cultural aspects rather than linguistic aspects.
Editorial Commentary: Anterior Cruciate Ligament Graft Fixation Strength: Do Ultimate Load and Cyclic Deformation Really Matter?

Abstract Surgeons, therapists, and industry are very focused on anterior cruciate ligament graft fixation strength, specifically ultimate load and cyclic deformation. Although many publications have focused on the importance of these values, no significant issues with early graft fixation failure or elongation have been recently been reported. Thus, instead of focusing on the absolute maximum values, it would be more helpful to define a minimum successful fixation strength, as well as determine how to test for physiologic cyclic elongation.
Should the Government be Allowed to Discriminate

The State of Arkansas has enacted a Distinguished Governor’s Scholarship Program that awards full college scholarships based solely on ACT or SAT scores. The purpose of the program is to keep “the best and brightest students” in Arkansas. As a matter of fact, fewer than 1% of the scholarships have gone to African-American and Hispanic students. Additionally, the scholarship monies are paid directly to both public and church-related institutions. The amount of aid paid to church-related colleges exceeds that awarded to public institutions.
Managing thromboembolic risk in patients with hereditary and acquired thrombophilias

Abstract While we are now able to diagnose inherited thrombophilias in a substantial number of patients with venous thromboembolism (VTE), the initial hope that their presence would inform recurrence risk and thus decisions on anticoagulation duration has largely been disappointing. Indeed, the presence or absence of transient provoking risk factors has proven to be the most important determinant of VTE recurrence risk. Thus, particular attention to transient acquired risk factors for VTE remains paramount, as they have generally been shown to carry more prognostic weight than inherited thrombophilias. The presence of other acquired risk factors may require additional management considerations, whether pertaining to anticoagulant choice, as in antiphospholipid antibody syndrome, or to addressing a new predisposing medical condition, as in malignancy. Antithrombin deficiency or the presence of ≥1 thrombophilic defect may be exceptions that can have a role in prognostication; however, as illustrated in this review through several case vignettes, interpretation and clinical application of the results of inherited thrombophilia testing is nuanced. We have chosen to focus on cases in which patients have been identified as having thrombophilic defects rather than the indications for undertaking testing in the first place or the extent of investigation. Management decisions in such cases ultimately hinge on individualized consideration of the benefits and risks of anticoagulation along with patient preference rather than on an algorithmic pathway based on thrombophilia status.
Cambio social y tendencias en la tasa de criminalidad: Un enfoque desde las actividades cotidianas

Las teorias del crimen irrumpieron en el estudio cientifico del delito a finales de la decada de 1970, siendo sin duda el articulo de Lawrence E. Cohen y Marcus Felson que aqui se traduce uno de los principales impulsores de ese cambio de perspectiva en el estudio y analisis de la delincuencia. Traduccion y nota previa: Miguel Angel Cano Panos.
Chronic prescription opioid use predicts stabilization on buprenorphine for the treatment of opioid use disorder.

Abstract Introduction Prescription opioid misuse is a risk factor for opioid use disorder (OUD). Patients who misuse prescribed opioids and those who misuse illicit opioids are demographically and medically distinct groups, and research has shown there is heterogeneity in treatment response between these groups. The objective of this study was to measure the adjusted odds of successful stabilization on buprenorphine in patients with baseline prescription opioid use compared to those not prescribed opioids. Methods A cohort of patients newly prescribed a buprenorphine product indicated for OUD between January 1 and November 30, 2018, were identified from the Texas Prescription Monitoring Program. We excluded those under the age of 15 and those who filled an opioid prescription after initiating buprenorphine to limit misclassification. We then stratified the cohort based on type of prescription opioid use in the pre-index period. We defined chronic opioid use as being prescribed opioids for a period of 90 out of 120 days, ending no sooner than 90 days prior to treatment initiation. We defined acute opioid use as filling any opioid prescription in the 90 days prior to initiating buprenorphine. The outcome of interest—stabilization on buprenorphine—was met by filling two prescriptions totaling 30-days' supply with no more than a six-day gap in therapy. We used multiple logistic regression to estimate the odds of stabilization in the prescription opioid use categories compared to those with no pre-index, opioid prescriptions. Results Among 6756 eligible patients, 44.1% used prescription opioids in the 90 days prior to buprenorphine initiation. Of these, 62.2% met the criteria for acute prescription opioid use and 37.8% for chronic prescription opioid use. Patients with prescription opioid use at baseline were more likely to be older and insured compared to those with no prescription opioid use. After adjustment for covariates, both prescription opioid use groups were significantly more likely to be successfully stabilized on therapy (Acute: aOR = 1.53, 95% CI = 1.37–1.72; Chronic: aOR = 2.43, 95% CI = 2.08–2.85). In a second model, those with chronic prescription opioid use were significantly more likely than those with acute prescription opioid use to be successfully stabilized (aOR = 1.60, 95% CI = 1.31–1.90). Conclusion Persistence to buprenorphine treatment for OUD is, in part, dependent on baseline prescription opioid use. This study suggests that patients with chronic prescription opioid use may be more likely than nonprescription opioid users to be successfully stabilized on treatment and may thus benefit more from pharmacotherapy with buprenorphine than those with no prescription opioid use. Failing to account for this variation in future studies of buprenorphine treatment persistence may lead to significant residual confounding and biased results. Extending access to buprenorphine among those with prescription OUD may have a significant impact on opioid related morbidity and mortality.
Using waste CO2 to increase ethanol production from corn ethanol biorefineries: Techno-economic analysis

Abstract Sustainable conversion of carbon dioxide (CO2) to value-added chemicals or fuels shifts a linear “cradle to grave chemicals or fuels manufacturing model” to a circular carbon economy. A key consideration for CO2 utilization is the economic viability of converting specific CO2 sources based on scale, purity, etc. Among different CO2 sources, the corn dry mill ethanol plant with onsite waste CO2 upgrading is considered as a low hanging fruit strategy for implementing CO2 utilization with minimum requirements for gas purification. This study investigates the detailed techno-economic analysis of using a hybrid bio-electrochemical process to convert waste CO2 streams from corn dry mill facilities into ethanol and demonstrates the impact of CO2 utilization on the biorefinery economics. The bio-electrochemical CO2 conversion process combines water electrolysis to hydrogen (H2), electrolysis of CO2-to-carbon monoxide (CO), and gas fermentation to ethanol. With onsite CO2 conversion, total ethanol yield can be potentially improved by 45%. In this study, variations of H2:CO ratio ranging from 0 to 5 are explored to understand the impact of gas mixture composition on economic viability. The techno-economic analysis results show single-pass carbon yield in the biological conversion step can be potentially improved up to 100% when using H2 as an alternative energy source. Upgrading waste CO2 generated from a corn dry mill facility via biological CO2 to ethanol conversion is likely to be cost effective under the following conditions: high CO2 electrolysis energy efficiency (≥70% theoretical), low electricity cost (≤$0.02/kWh), and high CO2 electrolysis conversion efficiency (≥50% CO2 input).
Free Speech v. Free Blacks: Racist policing and calls to harm

In 2018, mobile phone videos went viral of white people calling police to report Black people for engaging in innocuous conduct. Dubbed “white caller crime” by some commentators, mainstream and soc...
Human papillomavirus awareness among foreign- and US-born Hispanics, United States, 2017-2018.

Abstract Introduction Human papillomavirus (HPV) and HPV vaccine knowledge and awareness are known to be lower among Hispanics compared to non-Hispanic whites. However, Hispanics in the US are a non-homogenous population, with significant differences by nativity, particularly between the US-and foreign-born individuals. We examined HPV and HPV vaccine awareness among foreign-born Hispanics, US-born Hispanics, and US-born non-Hispanic whites. Methods We analyzed data from the Health Information National Trends Survey (HINTS) 5, cycles 1 (2017) and 2 (2018), the most recent HINTS datasets including nativity information. We used descriptive statistics and multivariable regression to compare awareness of HPV and the HPV vaccine among ethnicity/nativity subgroups. Results Over 50% of foreign-born Hispanics had not heard of HPV, compared to 32% of US-born Hispanics (P Conclusion There are significant nativity-related differences in HPV and HPV vaccine awareness and knowledge among US-born Hispanics. Over 50% of foreign-born Hispanic adults are unaware of HPV and the HPV vaccine.
The New Company

The new company is a dynamic work environment driven more by technology and data. Resourcing requires skills that also adapt to the changing environment. In seeking the right skills organizations have always sought to identify the perfect, better called the mythical profile. The definition of data science makes it hard to find the one data scientist skilled in all domains. This is more a team effort with combined skills. Automation, robotics, and AI ought to be viewed less as job loss risks, and more as opportunities for enhanced productivity and new possibilities. True AI will make many jobs obsolete, but it will also create new ones. We need to adjust, think, and work differently.
Detection of SARS-CoV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores.

The outbreak of the SARS-CoV-2 caused the disease COVID-19 to spread globally. Specific and sensitive detection of SARS-CoV-2 facilitates early intervention and prevents the disease from spreading. Here, we present a solid-state CRISPR-Cas12a-assisted nanopore (SCAN) sensing strategy for the specific detection of SARS-CoV-2. We introduced a nanopore-sized counting method to measure the cleavage ratio of reporters, which is used as a criterion for positive/negative classification. A kinetic cleavage model was developed and validated to predict the reporter size distributions. The model revealed the trade-offs between sensitivity, turnaround time, and false-positive rate of the SARS-CoV-2 SCAN. With preamplification and a 30 min CRISPR Cas12a assay, we achieved excellent specificity against other common human coronaviruses and a limit of detection of 13.5 copies/µL (22.5 aM) of viral RNA at a confidence level of 95%. These results suggested that the SCAN could provide a rapid, sensitive, and specific analysis of SARS-CoV-2.
Responsive foams for nanoparticle delivery

We have developed responsive foam systems for nanoparticle delivery. The foams are easy to make, stable at room temperature, and can be engineered to break in response to temperature or moisture. Temperature-responsive foams are based on the phase transition of long chain alcohols and could be produced using medical grade nitrous oxide as a propellant. These temperature-sensitive foams could be used for polyacrylic acid (PAA)-based nanoparticle delivery. We also discuss moisture-responsive foams made with soap pump dispensers. Polyethylene glycol (PEG)-based nanoparticles or PMMA latex nanoparticles were loaded into Tween 20 foams and the particle size was not affected by the foam formulation or foam break. Using biocompatible detergents, we anticipate this will be a versatile and simple approach to producing foams for nanoparticle delivery with many potential pharmaceutical and personal care applications.
Riemann Surfaces by Way of Complex Analytic Geometry

This book establishes the basic function theory and complex geometry of Riemann surfaces, both open and compact. Many of the methods used in the book are adaptations and simplifications of methods from the theories of several complex variables and complex analytic geometry and would serve as excellent training for mathematicians wanting to work in complex analytic geometry. After three introductory chapters, the book embarks on its central, and certainly most novel, goal of studying Hermitian holomorphic line bundles and their sections. Among other things, finite-dimensionality of spaces of sections of holomorphic line bundles of compact Riemann surfaces and the triviality of holomorphic line bundles over Riemann surfaces are proved, with various applications. Perhaps the main result of the book is Hormander's Theorem on the square-integrable solution of the Cauchy-Riemann equations. The crowning application is the proof of the Kodaira and Narasimhan Embedding Theorems for compact and open Riemann surfaces. The intended reader has had first courses in real and complex analysis, as well as advanced calculus and basic differential topology (though the latter subject is not crucial). As such, the book should appeal to a broad portion of the mathematical and scientific community.
Assessing Attitudinal Congruence in the Buying Center

Although the concept of multi-person buying centers is widely recognized, industrial marketing researchers still rely primarily on survey data supplied by a single company informant. This paper reports on a study which shows that buying center participants have varying beliefs about variables which are central to a purchase decision: This study lends added weight to the importance of studying more than one informant per company when strategy is based on understanding buyer behavior.
CITIZENS PARTICIPATION AND THE NEW ENVIRONMENTALISM

Citizen participation within the new environmentalism movement is having a profound impact on planning strategies. The new environmentalism movement has shifted the citizen participation debate from the urban planning to the regional planning sector. The new environmentalism debate is calling for a new system of recognition of the consequences on the environment by regional development strategies. Traditionally, consequences of development strategies within the urban planning sector have been met with land-use zoning. The use of land-use zoning as an urban planning tool has been delegated to localities by states under the guise of public health. The regional citizens participation debate is calling for a concomitant movement that gave the urban planning sector land-use zoning. To provide the regional planning sector with a similar planning tool, such as land-use zoning, it will be necessary to restore some of the delegated powers of the states.
Schritt 5: Internetmarketing – entfalten Sie durch Top-Inhalte auf Ihrer Internetseite eine unwiderstehliche Sogwirkung

Mit einer qualitativ hochwertigen Internetseite, die Expertenwissen pur bietet, entwickeln Sie eine Sogwirkung, entfachen Kaufenergie und halten Ihre Kunden auf Ihrer Internetseite. Wichtig ist, den Kunden mit fesselnden Inhalten zu uberzeugen – dabei spielen Videos eine besondere Rolle. Darum erfahren Sie, wie Sie professionelle Videos erstellen. Naturlich gibt es neben der professionellen Erstellung der Videos weitere Aspekte des Internetmarketings, die Sie berucksichtigen sollten, so das Social Bookmarking. Indem Sie bei Facebook, Twitter, Xing und Youtube prasent sind und Ihre Internetseite mit den Social Medias verlinken, verstarken Sie den Sog Ihrer Homepage. Die Inhalte auf Ihrer Website entscheiden daruber, ob der Kunde Sie als Experten wahrnimmt und aus diesem Grund einen Online-Termin mit Ihnen vereinbart.
Emission energy tuning of InAs-quantum dots for fabrication of broadband superluminescent diodes

Multiple layers of InAs quantum dots (QDs) where the dots height was tuned from one layer to another have been grown and characterized. The desired dots height within one layer was controlled by the thickness of the GaAs cap layer grown at low temperature (@510°C) before annealing the dots to 610°C. Four combined layers of QDs where the thickness of the cap layer was varied from 2.8nm to 6.5nm resulted in a photoluminescence spectrum with full width at half maximum of 125 nm at peak wavelength energy of 1.06 μm. Overlapping several layers of QDs of different heights is a reliable and predictable approach that can be used to engineer the bandwidth emission spectrum for fabrication of 1μm broadband superluminescent diodes. 3 dB and 10dB bandwidth of 100 nm and 230nm were obtained under 200mA injection current in CW operation mode at 55K, respectively.
Of Boundaries and Borders: First Nations' History in Museums

Abstract: This paper suggests that traditional history museums can be approached as maps that to orient their users to linear, culturally specific narratives of time and space. As an alternative, the paper proposes that we consider museum as borderlands: spaces of coexistence, negotiation, and transformation which do not assume given centres of power. Resume: Les musees d'histoire traditionnels sont presentes comme des cartes routieres qui orientent les visiteurs a travers des constructions qui sont non seulement lineaires mais aussi culturellement determinees dans le temps et l'espace. Cet article propose une vision alternative des musees en tant que terrains neutres de rencontre, c'est-a- dire comme des lieux de coexistence, de negociation et de transformation qui ne supposent pas de centres de pouvoirs pre-etablis.
Canonical Geometric Modeling For Computer Aided Design

The objective of this paper is to describe a unified and flexible geometric model which is called a canonical geometric model.
Factors influencing quality of life in breast cancer survivors

Longitudinal data from 195 breast cancer survivors were used to identify factors affecting the level and rate of change in quality of life after completion of treatment. Women were interviewed up to four times at approximately yearly intervals using Kaplan and Bush's Quality of Well Being instrument (QWB). Random coefficient regression analysis was used to model QWB as a function of time since diagnosis and personal characteristics. QWB scores decreased over time and the rate of decline increased with age (p = 0.032). This was similar to declines in women with benign breast biopsies, but overall QWB levels were lower in women with breast cancer. Having a spouse tended to slow the rate of decline in breast cancer survivors (p = 0.004). The presence of comorbidity was associated with significantly lower QWB levels (p = 0.037) but did not affect the rate of change over time. Education, family history of breast cancer, cancer stage and treatment modalities were not significantly related to QWB levels or rates of change. Breast cancer survivors experience a reduction in quality of life that persists for years after treatment and is similar in magnitude to that associated with other health problems.