cssi/SciSciGPT-SciSciNet huggingface dataset:
SGK1 Regulation by miR-466g in Cortical Collecting Duct Cells.

Micro-RNAs (miRNAs) are noncoding RNAs that bind target mRNA transcripts and modulate gene expression. In the cortical collecting duct (CCD), aldosterone stimulates the expression of genes that increase activity of the epithelial sodium channel (ENaC); in the early phase of aldosterone induction, one such gene is serum and glucocorticoid regulated kinase 1 (SGK1). We hypothesized that aldosterone regulates the expression of miRNAs in the early phase of induction to control the expression of target genes that stimulate ENaC activity. We treated mpkCCDc14 cells with aldosterone or vehicle for 1 h and used a miRNA microarray to analyze differential miRNA expression. We identified miR-466g as a miRNA that decreased by 57% after 1 h of aldosterone treatment. Moreover, we identified a putative miR-466g binding site in the 3'-untranslated region of SGK1. We constructed an SGK1 3'-untranslated region luciferase reporter and found that cotransfection of miR-466g suppressed luciferase activity in human embryonic kidney-293 cells in a dose-dependent manner. Deletion or introduction of point mutations that disrupt the miR-466g target site attenuated miR-466g-directed suppression of luciferase activity. Finally, we generated stably transduced mpkCCDc14 cell lines overexpressing miR-466g. Cells overexpressing miR-466g demonstrated 12.9-fold lower level of SGK1 mRNA compared with control cells after 6 h of aldosterone induction; moreover, cells overexpressing miR-466g exhibited 25% decrease in amiloride-sensitive current after 6 h of aldosterone induction and complete loss of amiloride-sensitive current after 24 h of aldosterone induction. Our findings implicate miR-466g as a novel early-phase aldosterone responsive miRNA that regulates SGK1 and ENaC in CCD cells.
Hageman factor activation and kinin formation in human plasma induced by cellulose sulfate solutions.

SummaryCellulose sulfate was previously reported as an anticoagulant and as a substance that will induce kinin formation in normal human plasma in vitro. The present data confirm these findings but in addition indicate that at lesser concentrations it is a procoagulant as well. Further, cellulose sulfate will induce permeability-enhancing activity in normal human plasma. Cellulose sulfate does not induce the formation of kinins, or permeability-enhancing activity, nor does it enhance clotting when added to human plasma deficient in Hageman factor. Further the induction of permeability-enhancing activity in normal human plasma is blocked by the addition of rabbit anti-Hageman serum prior to the addition of cellulose sulfate. These data therefore indicate that cellulose sulfate, like ellagic acid, activates Hageman factor in normal human plasma in vitro. On the basis of this datum, it is suggested that the mechanism of kinin formation and kininogen depletion in dogs given cellulose sulfate (4) is the same a...
Asymmetrical Incorporation of C14 Acetate into β-Carotene Biosynthesized by Phycomyces blakesleeanus.

Summaryβ-carotene biosynthesized by Phycomyces blakesleeanus was purified by column chromatography over basic silicic acid. Degradation studies on the ring system of this radioactive β-carotene indicate that the carboxyl carbon of acetate is incorporated into positions 1, 1′, 3, 3′, 5 and 5′ of the ring system whereas the methyl carbon is incorporated into all positions of the ring system. Our studies also indicate that the ring carbons are more radioactive than the side chain carbon atoms.
Computer Simulation of Methanol Exchange Dynamics around Cations and Anions.

In this paper, we present the first computer simulation of methanol exchange dynamics between the first and second solvation shells around different cations and anions. After water, methanol is the most frequently used solvent for ions. Methanol has different structural and dynamical properties than water, so its ion solvation process is different. To this end, we performed molecular dynamics simulations using polarizable potential models to describe methanol–methanol and ion–methanol interactions. In particular, we computed methanol exchange rates by employing the transition state theory, the Impey–Madden–McDonald method, the reactive flux approach, and the Grote–Hynes theory. We observed that methanol exchange occurs at a nanosecond time scale for Na+ and at a picosecond time scale for Cs+, Cl–, and I–. We also observed a trend in which, for like charges, the exchange rate is slower for smaller ions because they are more strongly bound to methanol.
Some Observations on Selected Species of Clavariadelphus

(1971). Some Observations on Selected Species of Clavariadelphus. Mycologia: Vol. 63, No. 5, pp. 1073-1076.
Occult mood in musculoskeletal diseases.

Psychophysiologic musculoskeletal reactions are common. Tightening of muscles secondary to emotional stress certainly can cause or aggravate pain. Many studies suggest a relationship between stress or personality characteristics and rheumatoid arthritis. Certain personality characteristics have been associated with gout, and it has been suggested that emotional factors may affect osteoarthritis.
Social gender-Female, Sex and AIDS

The proportion of females with sexually transmitted AIDS has been significantly increased in recent years both in China and around the world. Females, sex and AIDS are closely related. There seems to be a tendency of having more women AIDS patients in the society. Some researches indicated that females are more vulnerable than males in physiology. Their weak social gender and disadvantaged social position constitute the important reasons for their vulnerability for AIDS. Therefore, sociological understanding of the relationship between women, sex and AIDS will be very helpful to explore the reason for the tendency of more women AIDS patients.
KPMG Knowledge Management and the Next Phase: Using Enterprise Social Media

ABSTRACT: The purpose of this paper is to present a case study summarizing some of the issues associated with KPMG's knowledge management system and their recent adoption of social media for collaboration and knowledge management. In particular, this case examines KPMG's knowledge management initiative starting roughly when Robert Armacost was hired to lead the global firm's efforts in knowledge management, from 2007 through 2014, with KPMG's adoption of social media as part of their knowledge management system. This case study shows a fundamental and strategic shift in knowledge management at KPMG from focusing on content to including collaboration. In addition, this paper illustrates some of the advantages of including enterprise social media as part of the knowledge management system.
Higher order structures in purine and pyrimidine metabolism

The recent discovery of several forms of higher order protein structures in cells has shifted the paradigm of how we think about protein organization and metabolic regulation. These dynamic and controllable protein assemblies, which are composed of dozens or hundreds of copies of an enzyme or related enzymes, have emerged as important players in myriad cellular processes. We are only beginning to appreciate the breadth of function of these types of macromolecular assemblies. These higher order structures, which can be assembled in response to varied cellular stimuli including changing metabolite concentrations or signaling cascades, give the cell the capacity to modulate levels of biomolecules both temporally and spatially. This provides an added level of control with distinct kinetics and unique features that can be harnessed as a subtle, yet powerful regulatory mechanism. Due, in large part, to advances in structural methods, such as crystallography and cryo-electron microscopy, and the advent of super-resolution microscopy techniques, a rapidly increasing number of these higher order structures are being identified and characterized. In this review, we detail what is known about the structure, function and control mechanisms of these mesoscale protein assemblies, with a particular focus on those involved in purine and pyrimidine metabolism. These structures have important implications both for our understanding of fundamental cellular processes and as fertile ground for new targets for drug discovery and development.
Reliability and comparison of trunk and pelvis angles, arm distance and center of pressure in the seated functional reach test with and without foot support in children

This study determined test-retest reliability of trunk and pelvis joint angles, arm distance and center of pressure (COP) excursion for the seated functional reach test (FRT) and compared these variables during the seated FRT with and without foot support. Fifteen typically developing children (age 9.3±4.1years) participated. Trunk and pelvis joint angles, arm distance, and COP excursion were collected on two days using three-dimensional motion analysis and a force plate while subjects reached maximally with and without foot support in the anterior, anterior/lateral, lateral, posterior/lateral directions. Age, weight, height, trunk and arm lengths were correlated (p 0.75) was found for maximum arm distance reached in all four directions in the seated FRT with and without foot support. Most trunk and pelvis joint angles and COP excursions during maximum reach in all four directions showed excellent to fair reliability (ICCs>0.40-0.75). Reaching with foot support in all directions was significantly greater (p<0.05) than without foot support; however, most COP excursions and trunk and pelvic angles were not significantly different. Findings support the addition of anterior/lateral and posterior/lateral reaching directions in the seated FRT. Trunk and pelvis movement analysis is important to examine in the seated FRT to determine the specific movement strategies needed for maximum reaching without loss of balance.
Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis

Abstract During ribosome biogenesis in eukaryotes, nascent subunits are exported to the cytoplasm in a functionally inactive state. 60S subunits are activated through a series of cytoplasmic maturation events. The last known events in the cytoplasm are the release of Tif6 by Efl1 and Sdo1 and the release of the export adapter, Nmd3, by the GTPase Lsg1. Here, we have used cryo‐electron microscopy to determine the structure of the 60S subunit bound by Nmd3, Lsg1, and Tif6. We find that a central domain of Nmd3 mimics the translation elongation factor eIF5A, inserting into the E site of the ribosome and pulling the L1 stalk into a closed position. Additional domains occupy the P site and extend toward the sarcin–ricin loop to interact with Tif6. Nmd3 and Lsg1 together embrace helix 69 of the B2a intersubunit bridge, inducing base flipping that we suggest may activate the GTPase activity of Lsg1.
Abstract P089: Inhibition of AT1-AAs by Direct Binding Reduces Blood Pressure and Natural Killer Cell Activation in Response to Placental Ischemia of Pregnancy; Emphasizing the Importance of Novel Drug Development in the Treatment of Preeclampsia

Preeclampsia (PE), hypertension with proteinuria during pregnancy, is associated with activating antibodies to the angiotensin II receptor (AT1-AA) and activation of cytolytic natural killer (NK) cells. The objective of our study was to determine if AT1-AA inhibition inhibits cytolytic NK cell activation in the reduced uterine perfusion pressure (RUPP) rat model of PE. We utilized a novel approach of specific epitope binding to inhibit AT1-AAs: AT1-AA inhibitory peptide (2ug/ml saline) was infused via miniosmotic pumps into RUPP rats beginning on day 14 of gestation. On day 19 of gestation, blood pressure (MAP) was measured and flow cytometry was performed to measure total and cytolytic NK cells in renal and placental tissues from all groups of rats. MAP significantly increased from 87.1±6.2 in NP (n=5) to 125±2.3 in RUPP (n=6). Inhibition of AT1-AA by direct binding attenuated the hypertensive response to 74.9±19.02 mmHg in RUPP + AT1-AA inhibitor (n=3). Total renal NK cells measured at 10.21±3.69% in NP, 24.19±6.63% in RUPP, and 14.25±7.52% in RUPP + AT1-AA inhibitor. Total placental NK cells were 6.87±2.84% in NP (n=6), 27.62±10.97% in RUPP (N=6), and 6.35±3.90% in RUPP + AT1-AA inhibitor (N=5) rats. Importantly, activated cytolytic placental NK cells were significantly increased in NP (0.44±.24%) compared to RUPP (11.87±2.06%), and was blunted after epitope binding of AT1-AA in RUPP + AT1-AA inhibitor (2.33±1.02%, p<.0001 vs RUPP). These studies indicate that AT1-AA inhibition improves maternal blood pressure and attenuates cytolytic activation of NK cells in response to placental ischemia, thereby emphasizing the importance of drug discovery for AT1-AA inhibition to improve pregnancy outcomes in preeclamptic patients.
Adiponectin, a Therapeutic Target for Obesity, Diabetes, and Endothelial Dysfunction

Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. In addition to adipocytes, other cell types, such as skeletal and cardiac myocytes and endothelial cells, can also produce this adipocytokine. Adiponectin effects are mediated by adiponectin receptors, which occur as two isoforms (AdipoR1 and AdipoR2). Adiponectin has direct actions in liver, skeletal muscle, and the vasculature.Adiponectin exists in the circulation as varying molecular weight forms, produced by multimerization. Several endoplasmic reticulum ER-associated proteins, including ER oxidoreductase 1-α (Ero1-α), ER resident protein 44 (ERp44), disulfide-bond A oxidoreductase-like protein (DsbA-L), and glucose-regulated protein 94 (GPR94), have recently been found to be involved in the assembly and secretion of higher-order adiponectin complexes. Recent data indicate that the high-molecular weight (HMW) complexes have the predominant action in metabolic tissues. Studies have shown that adiponectin administration in humans and rodents has insulin-sensitizing, anti-atherogenic, and anti-inflammatory effects, and, in certain settings, also decreases body weight. Therefore, adiponectin replacement therapy in humans may suggest potential versatile therapeutic targets in the treatment of obesity, insulin resistance/type 2 diabetes, and atherosclerosis. The current knowledge on regulation and function of adiponectin in obesity, insulin resistance, and cardiovascular disease is summarized in this review.
Self-management and health care transition: Trials, tribulations and triumphs

PURPOSE The purpose of this article is to provide perspectives pertaining to the importance of fostering comprehensive self-management competencies of AEA-SHCN, with attention directed to AEA with spina bifida based upon the Health Care Transition Research Consortium Health Care Transition model. This article is based upon the plenary presentation given at the Spina Bifida 3rd World Congress, entitled, Self-Management and Health Care Transition: Trials, Tribulations and Triumphs. METHOD A historical perspective of healthcare transition initiatives and best practice guidelines is provided that have influenced the field of research and practice. Relatively scant attention has been directed to the development and refinement of self-management competencies prior to the transfer of care and transition to adulthood. Against this backdrop of the predominant framework of care focused on the transfer of care, a discussion of our team's experience with the provision of healthcare transition services and the complexity of addressing the self-management needs of the adolescents and emerging adults (AEA) with spina bifida served in the Movin' On Up HCT program will be presented. RESULTS Through our clinical and research healthcare transition experience, insights pertaining to self-management will be presented. CONCLUSION The acquisition of self-management knowledge and skills is a complex process that extends far beyond learning the fundamental skills of daily condition management.
Characterization Results for the Skewed Double Exponential Distributions

In defining the skew-normal distribution, [1] introduced a method of modifying symmetric distributions to obtain their skewed counterparts. In this paper, the authors present moment properties of the distribution obtained by adding skewness to the double exponential distribution, i.e. the Skewed Double Exponential(SDE) distribution ([6]). The authors also provide characterization results of distributions in the SDE family of distributions and present several interesting corollaries of the characterization results.
The Evaluation Profession as a Sustainable Learning Community

After nearly four decades of study and practice, the evaluation profession appears on the brink of moving from adolescence into early adulthood and to becoming a “major social force” (House, 1994, p. 239). I believe this move into adulthood signals not only another phase in the profession’s life, but a significant transformation in what it means to be an evaluator. In this chapter, I propose that the evaluation profession must strive to become a Sustainable Learning Community if it wishes to grow and develop in ways that add value and importance to organizations and society. In 1990, Patton suggested that for evaluation to develop as a profession worldwide it “needs three things: vision, quality products and processes, and skilled, trained evaluators” (p. 47). I will argue that in addition to these general goals, there are other goals as significant and potentially defining for the evaluation profession.
Hilbert Space Basics

We assume that you know the definition of a vector space V = (V, +, ·) over the field ℭ of complex numbers. Perhaps you recall defining an “inner product” between vectors in a vector space and using the inner product to consider angles between vectors. A ‘Hilbert space’ is a vector space with an inner product. We begin by defining an inner product space.
Cognitive Behavioral Therapy of Aggressive Children

Children who are identified as excessively aggressive by peers and teachers display a range of behaviors including verbal provocations and threats, physical fights, poorly controlled anger, low frustration tolerance, bullying, and disruptive behavior. Aggressive children typically have various subsets of these behavioral symptoms, and research and clinical efforts have focused on identifying meaningful subtypes of aggressive children. However, a common characteristic of all aggressive children is that they have intense, negative effects on the people who interact with them. Peers are victimized, teachers are disrupted from their teaching mission, and parents are frustrated with being unable to control these children’s coercive, provocative behavior. Because of these flagrant effects on others, aggressive children are referred for mental health services at higher rates than are children with most other forms of psychopathology.
OS-Based Energy Accounting for Asynchronous Resources in IoT Devices

Rapid advancements in computing, communication, sensing, and actuation have seen the growth of Internet of Things (IoT) devices in our daily life. One of the fundamental constraints of a typical IoT device is energy as IoT devices rely on a battery. Therefore, it is crucial for their operating system (OS) to be able to accurately account for system-wide energy usage. Specifically, the OS should be able to attribute such accounted energy to the running applications accurately. Traditional OSs have limited capability when it comes to tracking components such as sensors, actuators and network interfaces, as they are often used in an asynchronous fashion. This would make it difficult to conduct energy accounting accurately. This paper proposes a new mechanism to accurately account for the asynchronous energy usage of resources in mobile systems and IoT devices. Our insight is that by accurately relating the application requests with kernel requests to device and corresponding device responses, we can accurately attribute time of use to the requesting process. However, resources such as WiFi reception violate this assumption. In such cases, we can measure usage by the number of bytes in each individual transaction. Using such a hybrid approach, we can account for energy usage with 94% accuracy and perform much better than using each of these models individually.
Cross-validating traffic speed measurements from probe and stationary sensors through state reconstruction

Abstract Traffic speed on freeways can be measured by two types of technologies, i.e. probe sensors and stationary sensors. Cross-validation is critical to ensure the consistency between heterogeneous measurements. A challenge lies in the mismatch of probe and stationary measurements in space and time, especially when one of them is relatively sparse. Towards filling the gap, this paper presents a cross-validation method based on traffic state reconstruction. The proposed method is computationally simple and robust. This makes it ready to be implemented for large data sets without complicated tuning. We present analytical formulation of the proposed method and an analysis of its robustness property. We demonstrate the method using both simulation model and real-world freeway data. Results show that the method can effectively identify discrepancies between probe and stationary speed measurements.
More Than Money: Correlation among Worker Demographics, Motivations, and Participation in Online Labor Market

Most prior research about online labor markets examines the dynamics of a single work platform and either worker demographics or motivations associated with that site. How demographics and motives correlate with each other, and with engagement across multiple platforms, remains understudied. To bridge this gap, we analyze survey responses from 1700 people working across four different online labor platforms to understand: What motivates people to participate in online labor markets and how do individual motives correspond to larger demographic patterns and structural dynamics that more broadly shape traditional employment opportunities? Our results show that age, gender, education, and number of income sources help explain who does ondemand work, when they do it, and why. Even more striking, these broader social dimensions of work correlate with when and why individuals work across multiple on-demand platform companies. Together, these factors structure ondemand labor markets more than individual choice or the presumed “flexibility” of on-demand work alone.
Nonclassical Features of Dorsal Root Ganglion Cell Organization

Dorsal root ganglion cells and their cranial nerve equivalents are the primary sensory cells for general somatic sensation. The cell bodies of these neurons are located in dorsal root and certain cranial nerve ganglia. Each cell body is reported to give rise to a single stem process that branches into a proximal and a distal process, the proximal process entering the spinal cord through a dorsal root and the distal process passing to the periphery via a peripheral nerve. This organization is schematized in Figure 1, and similar pictures are seen in almost all texts dealing with the organization of the nervous system. This is an important scheme, for it imposes restraints on the way we reason about the transfer of somatic information centrally. In recent years, however, evidence has accumulated to indicate that two aspects of the above scheme are oversimplified. These are (1) that each dorsal root ganglion cell has a single process in the dorsal root and a single process in the peripheral nerve and (2) that the central processes of dorsal root ganglion cells travel only in the dorsal root. This report indicates how we arrived at the classic scheme and then presents the evidence indicating that the classic scheme needs modification. Some speculations as to the functional significance of these modifications are offered.
Clinical meaning of PROMIS pain domains for children with sickle cell disease

The Patient Reported Outcomes Measurement Information System (PROMIS) pain interference and pain behavior domains are valid and reliable for children with sickle cell disease (SCD). However, clinical interpretation of the scores is unknown. The objective of this study was to determine the clinical meaning of PROMIS pain scores for children with SCD. We used 2 approaches to determine clinical meaning: dichotomization of item responses and T-score ranges. T-score ranges determined thresholds for no/mild, moderate, and severe pain. We compared the proportion of patients who needed pain medications among pain severity groups using χ2/Fisher’s exact tests. The study included 117 children (mean age, 11.5 years [standard deviation, 2.9 years]). Using the dichotomization approach, 43 children had pain interference T-scores ≤48 reflecting minimal pain, and 30 children had T-scores >60 reflecting substantial pain. For pain behavior, 34 children had T-scores ≤41 reflecting minimal problems, and 23 patients had T-scores >57 reflecting substantial problems with pain. Using T-score ranges, clinical thresholds of no/mild and severe pain interference were determined as ≤48.3 and >63.6, respectively. The thresholds for no/mild and severe pain behavior were ≤41.3 and >57.3, respectively. Overall, the proportion of patients who took pain medications was significantly different among those with no/mild, moderate, and severe pain as identified by pain interference (P = .002) and pain behavior domains (P = .0113). We identified T-scores for PROMIS pain domains that facilitate clinical interpretation and provide necessary information for PROMIS users in a clinical setting.
Provider Perceptions of Quality of Life, Neurocognition, Physical Well-being, and Psychosocial Health in Patients with Primary Immunodeficiency/Immune Dysregulation Conditions.

Both pediatric and adult patients with a primary immunodeficiency/immune dysregulation (PID/PIDR) diagnosis report inferior quality of life (QOL) and patient-reported outcomes (PROs) as compared with their healthy peers. Recognition of the negative impact on QOL and PROs provides an opportunity for clinicians to intervene with supportive measures. However, provider perceptions of PID/PIDR patients’ quality of life, physical well-being, psychosocial health and neurocognition, and access to supportive resources have yet to be systematically evaluated. We report specialty providers’ perception of the QOL and psychosocial and physical well-being of their pediatric and adult patients with PID/PIDR through the utilization of an online survey assessing QOL and the impact of disease or its associated treatment on their physical well-being, mental health, social relationships, neurocognition, and work/school performance. Clinicians trended towards believing adult PID/PIDR patients had worse overall QOL than children with PID/PIDR. Providers additionally identified their adult patients’ QOL to be more deleteriously affected by co-morbidities than their pediatric patients. Clinicians distinguished anxiety and social relationships as the psychosocial aspects most often affected by a complex immunological diagnosis in all patients. Of physical health considerations, energy, rather than mobility or pain, was perceived to be more negatively influenced by PID/PIDR in both adult and pediatric patients. Knowledge of these clinician perceptions can affect communication of findings with patients, as well as ongoing management, and thus, it is important to understand these fully to improve healthcare delivery to, and clinical management of, these patients.
Myocardial Ischemia in Children With Anomalous Aortic Origin of a Coronary Artery With Intraseptal Course

Background: Intraseptal anomalous aortic origin of a coronary artery is considered a benign condition. However, there have been case reports of patients with myocardial ischemia, arrhythmia, and su...
Bumblebee-Inspired C-V2X Dynamic Spectrum Access Testbed Using OpenAirInterface

Cellular Vehicle-to-everything (C-V2X) was introduced by 3GPP in Release 14, which supports direct vehicle-to-vehicle (V2V) communication using sidelink channels. There are two modes in C-V2X for supporting V2V communication: Mode 3 and Mode 4. Both modes support V2V communications but differ on their spectrum allocation methodology. In out-of-coverage scenario defined under Mode 4, vehicles reserve spectrum resources using semi-persistent scheduling to enable direct communication. Currently, Intelligent Transportation System (ITS) spectrum at 5.9 GHz is emerging as an immediate resource to facilitate vehicular communication which has already been assigned for IEEE 802.11p. However, these dedicated channels will not be sufficient to support the connected vehicles in densely populated cities. Leveraging the existing underutilized wireless spectrum elsewhere, such as in digital television spectrum band is a likely solution. An intelligent scheme is required which can make adaptive decisions based on channel environment to efficiently use the secondary spectrum. Bumblebee behavioral model possess evolved decision-making mechanisms to adaptively solve similar problems while foraging in environments containing multiple floral resources (channels). Simulation results using bumblebee-based algorithm have shown that a memory system based on the averaging of stored channel energy information dramatically increased VDSA performance over a memoryless system in both urban and highway scenarios by 52% and 20%, respectively. In this paper, we propose a vehicular dynamic spectrum access (VDSA) solution based on bumblebee behavioral model for C-V2X and evaluate its performance using OpenAirInterface (OAI) LTE-Sidelink platform.
BRIDGING THE GAP FROM STUDENT TEACHER TO CLASSROOM TEACHER

This study focuses on providing support for beginning teachers to increase retention in the career. Despite strong requirements for teacher preparation, the attrition rate for new teachers continues to show that many novice teachers leave the profession within the first four years or less. This qualitative case study of teachers who completed a Professional Development School Model for teacher preparation has shown success in teacher readiness for the classroom and in retention in the career. Interview data showed positive outcomes including confidence in the content and pedagogical skills and a strong expectation for continuation in the teaching career. However, identified gaps in the transition phase during the first year suggest that additional support is needed to assure a successful first year and ongoing retention. Key variables are identified, including adaptation to different school culture, feelings of isolation, lack of support, and uncertainty about job expectations. These negatively impact success in the first year. Interventions and strategies to prevent these gaps in a successful transition are described. The Professional Development School Model can include preparation to help beginning teachers anticipate initial challenges. Optimum support includes focused actions by the school district, the school, and particularly, the school principal. Support strategies include mentoring, communication of clear expectations, strong instructional leadership, availability of resources, opportunities for professional development, and a focus on wellness. Future study should address the impact of the implementation of these strategies to bridge the gap in success in the first year and retention in the career.
Management challenges at end-of-life in a patient with agitated delirium and benzodiazepine withdrawal at comprehensive cancer care center

Most people have some idea of how they want to live their life; however, an estimated two-thirds of Americans have not completed their advance directives. This becomes an issue when up to 90% of patients develop delirium during their final days of life, at which point we depend on advance directives or surrogate decision-makers. Here, we present a case of terminal delirium in a patient with advanced cancer and a history of alprazolam abuse who had not discussed his end-of-life wishes with the medical team or with his estranged family. Treatment was provided to address reversible causes of delirium, including correcting electrolyte imbalances, urinary retention, and administered antibiotics for purulent otitis media. Hyperactive delirium was managed aggressively with intravenous neuroleptics and benzodiazepine, while keeping a balance between somnolence and control of agitative symptoms. Without knowing the patient's wishes, the family continued to struggle with decision making. However, with multidisciplinary team approach patients and caregivers' symptoms were better managed. Family then requested us to transfer him to a local hospice facility. The patient eventually passed away peacefully surrounded by his family members. This case highlights the importance of advance care planning, addressing emotional distress in estranged family members regarding symptom burden, and developing the appropriate treatment regimen for a delirious patient with a history of benzodiazepine abuse. Our case serves as a reminder of the support, guidance, and impact that inpatient palliative care teams can offer to both the patient and caregivers.
Between the state and the yard: gender and political space in Haiti

This article examines the gendered political geography of postcolonial Haiti. It draws from the author's long-term ethnographic fieldwork with the Mouvman Peyizan Papay (MPP), a peasants' movement ...
Sanghuangporus vitexicola sp. nov. (Hymenochaetales, Basidiomycota) from tropical Taiwan

Sanghuangporus vitexicola (Hymenochaetales) is described as a new species based on collections made from Pingtung County, tropical South Taiwan. All studied basidiocarps grew on living trunks of Vitex negundo. This new species is characterized by having perennial, pileate basidiocarps; pore surface yellowish brown, pores 6–8 per mm; context 0.7–1.5 cm thick; setae ventricose to subulate, dark brown, 17–30 × 5–8 μm; basidiospores broadly ellipsoid, brownish, smooth, 4.2–4.8 × 3.2–3.7 μm, with 0.2–0.5 μm thick walls. Maximum likelihood and Bayesian inference phylogenies inferred from the internal transcribed spacer (ITS) region of rDNA indicated that six strains of Sanghuangporus viexicola formed a monophyletic group which is sister to S. zonatus. An identification key to known species of Sanghuangporus is provided.
Handheld Technology Selection, Evaluation, and Risk Mitigation Using Stochastic Analytical Hierarchical Process: A Standardization of the Request for Proposal Process

Organizations deploying ruggedized handhelds experience complex device selection processes. The engineering manager-led decision-making process combines device-to-task fit and field service life. T...
Clinical Examination and History Taking in Patients with Suspected Degenerative Disc Disease

Degenerative disc disease is common in the adult population and may be managed conservatively or with surgical intervention. The key to effective treatment is careful patient assessment, including history taking, physical examination, selection of appropriate imaging, and ultimate triage to medical or surgical management. This chapter will focus on the important history and physical exam findings for patients with cervical and lumbar degenerative disc disease and address appropriate imaging required for further management and treatment decisions. Case presentations will illustrate these diagnostic steps in patient assessment and treatment.
Capture fast volumetric dynamics in the brain by light field microscopy

Life is dynamic and three-dimensional (3D). An ideal tool to study biological processes, particularly those involving large populations of functionally diverse cells and fast dynamics, such as brains, is to achieve volumetric imaging in vivo. Traditional imaging tools, such as point scanning confocal microscope, are too slow to catch rapid processes over large scales. Volumetric imaging techniques that completely parallelized the imaging collection start attracting increasingly more attentions recently. Here, we report several new types of light field microscopes that can do functional imaging of calcium activities over large populations of neurons at high speed. We demonstrated whole brain functional imaging in freely behaving larval zebrafish and captured activation of several functional neural ensembles during different phases of larval zebrafish prey capture behavior. We also recorded populations of neurons’ activity and track fast circulating blood cells in 3D vascular network in the mouse brain. We believe these volumetric high speed imaging techniques could open new windows to understand more dynamic biological processes in vivo.
Methylation markers associated with air pollution exposure and cardiometabolic health in the Framingham Offspring Study

BACKGROUND AND AIM: We conducted a systematic literature review to identify methylation (CpG) sites associated with air pollution exposure. We assessed if these CpG sites were associated with air p...
Shock melting and the hcp-bcc phase boundary of Mg under dynamic loading

The high-temperature and high-pressure response of magnesium has been investigated through shock-release experiments performed up to shock melting. The longitudinal and bulk sound speeds of Mg are reported along the Hugoniot from 25 to 56 GPa and used to determine the elastic properties and Gr\"uneisen parameter. The hexagonal close-packed (hcp)--body-centered cubic (bcc) phase transition is marked by a reduction in the determined shear wave speed. Thermal softening is observed to begin between 40 and 44 GPa, with incipient melt at 55.5 GPa, in close agreement with previous diffraction measurements under laser shock loading. Examination of the release profiles showed that two different responses were observed, depending on the peak stress. When plotted in a stress-energy phase diagram, the two responses are observed to form separate lines that intersect the static hcp-bcc phase transition and incipient melt. The results indicate that the hcp-bcc transition occurs on the Hugoniot at 28.4 GPa and place the hcp-bcc-liquid triple point \ensuremath{\sim}20 GPa. A multiphase equation of state is developed which places the melt boundary below the previously reported static measurements.
Modeling and Experimental Characterization of Photonic Bound States in Silicon-on- Insulator Metastructures

We report modeling and experimental characterization results of the propagating photonic bound states in a silicon-on-insulator (SOI) metastructure. The photonic bound states in the metasurface can be excited by the interaction between the discrete resonant modes and the incident wave. The calculated dispersion diagram shows anticrossings with continuous spectral narrowing at surface normal- and oblique-incidence excitations. In the presentation, we will discuss the measured spatial and spectral responses of the reflected beam from the fabricated SOI metastructure.
Is Political Ideology Endogenous? Evidence from the Business Cycle

We construct a time series of political party ideology, based on Poole and Rosenthal's (1997) NOMINATE scores, for the 1950-98 period. The results show that (1) party ideology has become increasingly more polarized over this period; and (2) that it is very sensitive to business cycle conditions. In particular, a worsening of economic conditions (e.g. higher inflation or unemployment) is associated with a decline of the relative difference in party ideology scores. Republicans tend to become "less conservative" relative to Democrats when either the unemployment or inflation rate increases. We obtain the same results using an equivalent time series based on ADA (Americans for Democratic Action) scores. That there is an important economic component in ADA and NOMINATE scores questions the ability to interpret these scores as proxies of legislator ideology. But the finding that political parties' platforms tend to converge during economic downturns is not inconsistent with the traditional Downsian-type approach of modeling party behavior.
Exterior Differential Systems in Control and Robotics

The vast majority of the mathematically oriented literature in the areas of robotics and control has been heavily influenced by a differential geometric point of view. For nonlinear systems in particular, most of the research has concentrated on the analysis of the Lie algebras associated with controllability, reachability and observability. In recent years, however, a small but influential trend has begun in the literature on the use of other methods, such as differential algebra [9, 8, 10] and exterior differential systems [13, 11] for the analysis of nonlinear control systems and nonlinear implicit systems. In this paper we survey some key results from the theory of exterior differential systems and their application to current and challenging problems in robotics and control.
Comparison of Amperometric and Coulometric Electrchemical Detectors for HPLC Through a Figure of Merit

Abstract Performance characteristics of electrochemical detectors for high performance liquid chromatooraphy are difficult to predict from presently avaliable information relating response to design parameters. A fiqure of merit is proposed which allows an operational comparison to be made, based upon specific response, noise and band spread. On this basis, it is shown that a meaningful comparison of an amperometric design with a coulometric design can be obtained and that, contrary to previous predictions, this coulometric type is generally superior.
The Role of Cytology in the Evaluation of Pericardial Effusions

Pericardial effusions from 47 patients were examined for cancer cells. Fluids from 13 of the 15 patients with neoplasm involving the pericardium were decisively “positive.” There were no false positive reports. Three patients had malignancy localized to the chest, but not metastatic to the pericardium. Effusions from these three patients contained no tumor cells. The accumulation of fluid in a patient with a known or suspected malignancy does not necessarily mean metastatic disease. Cytologic evaluation of these fluids is helpful in establishing a prognosis and mode of therapy.
Antigenic and structural characteristics of an immunoglobulin-related peptide purified from marmoset T-lymphoma cells☆

Abstract A 7800 M r peptide, apparently derived from a 70,000 M r immunoglobulin-related protein synthesized by a marmoset T-lymphoma cell line, bears immunoglobulin-related determinants apparently contained in a disulfide-bonded loop comparable to that of the V H fragment of classical H chain. A membrane-enriched, crude particulate fraction was prepared from marmoset T-lymphoma cells, and peptides generated by papain digestion of the particulate fraction were selectively purified by affinity chromatography using IgG purified from serum of a goat immunized with the Fab fragment of a human Waldenstrom macroglobulin. The smallest of the affinity-purified peptides was particularly reactive with unfractionated goat anti Fab (GαFab) serum, purified IgG from GαFab serum, and with antibodies affinity purified from GαFab serum using Waldenstrom macroglobulins. Partial specificity of GαFab antibodies was determined by competition radioimmunoassay and radioimmunoprecipitation assays. High-performance reverse-phase liquid chromatography was used for final purification of the smallest peptide which retained its reactivity with GαFab serum and affinity-purified GαFab antibodies. The apparent molecular weight of the peptide, determined by gel filtration in 6 M guanidine, was estimated at 3900 in its native state but increased to 7800 after reduction and alkylation, indicating a role for a disulfide bond in the tertiary structure of the peptide. The amino acid composition of the peptide was presented, and its possible relationship to immunoglobulin-like T-cell surface proteins was discussed.
Teaching about America's Fiscal Future in the University's Core Curriculum.

Civic engagement is increasingly recognized as a significant function of public universities. The university provides a variety of opportunities for civic engagement, including co-curricular activities, service learning opportunities, and specific majors and minors. This article reviews the attempt to embed civic engagement and civic education about the national debt and budget deficit issues in a university core curriculum course at Stephen F. Austin State University. We focus on specific issues of curriculum instruction and assessment of student learning of knowledge regarding the debt and deficit issues.
Preparing Science-Trained Professionals for the Biotechnology Industry: A Ten-Year Perspective on a Professional Science Master’s Program

The biotechnology industry has a need for business-savvy scientists; however, this is not the way scientists are traditionally trained at universities and colleges. To address this need, universities have developed Professional Science Master’s (PSM) degree programs that offer advanced training in a technical field along with professional skills development through team-based projects and internships. Nearly ten years ago, the Department of Microbiology at NCSU started a PSM program in Microbial Biotechnology (MMB). This article provides an overview of the MMB program, and shares some of the lessons that we have learned.
Influence of protamine zinc insulin upon appetite during anorexia of vitamin B1, deficiency.

SummaryThe administration of protamine zinc insulin which leads to a marked hyperalimentation in normal rats is without effect upon the depressed appetite of rats suffering from vitamin B1 deficiency. These deficient rats succumb in hypoglycemia without an increase in their food intake when the insulin is administered. When thiamin chloride is given to B1-deficient rats their appetite responds not only to the vitamin therapy but to protamine zinc insulin as do normal animals.
Convergent Genetic Algorithm For Inversion

A genetic algorithm shown last year finds the global maximum of correlation tyfrc functions when many near equal maxima arc present. It conserves al1 genetic material of the starting population in successive gcneralions and convcrgcs as long as the population size is of the order of the chromosome length The algorithm was tested on a 10 parameter function with approximately 106 peaks ranging in their peak amplitude from 1 to 1.582. The function values ranged from 0 to the maximum peak. Figure I shows a two parameter version. here WC present detailed proper&s, an extension for faster convergence and conditions for convergcncc easily monitored during processing.
Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium

The chemoreception of dietary fat in the oral cavity has largely been attributed to activation of the somatosensory system that conveys the textural properties of fat. However, the ability of fatty acids, which are believed to represent the proximate stimulus for fat taste, to stimulate rat trigeminal neurons has remained unexplored. Here, we found that several free fatty acids are capable of activating trigeminal neurons with different kinetics. Further, a polyunsaturated fatty acid, linoleic acid (LA), activates trigeminal neurons by increasing intracellular calcium concentration and generating depolarizing receptor potentials. Ion substitution and pharmacological approaches reveal that intracellular calcium store depletion is crucial for LA-induced signaling in a subset of trigeminal neurons. Using pseudorabies virus (PrV) as a live cell tracer, we identified a subset of lingual nerve-innervated trigeminal neurons that respond to different subsets of fatty acids. Quantitative real-time PCR of several transient receptor potential channel markers in individual neurons validated that PrV labeled a subset but not the entire population of lingual-innervated trigeminal neurons. We further confirmed that the LA-induced intracellular calcium rise is exclusively coming from the release of calcium stores from the endoplasmic reticulum in this subset of lingual nerve-innervated trigeminal neurons.