cssi/SciSciGPT-SciSciNet huggingface dataset:
Extension and software development

Enhancement is the most costly phase of the software development life-cycle. By developing an extension mechanism that allows users to augment a software system without modifying the underlying source code, we address enhancement directly. We describe the design and implementation of the extension mechanism. We also demonstrate how the availability of this flexible mechanism alters not only the enhancement phase of the life-cycle, but the design and implementation phases as well.
Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

Trypanosoma brucei subspecies infect humans and animals in sub-Saharan Africa. This early diverging eukaryote shows many novel features in basic biological processes, including the use of polycistronic transcription to generate all protein-coding mRNAs. Therefore we hypothesized that translational control provides a means to tune gene expression during parasite development in mammalian and fly hosts. We used ribosome profiling to examine genome-wide protein synthesis in animal-derived slender bloodstream forms and cultured procyclic (insect midgut) forms. About one-third of all CDSs showed statistically significant regulation of protein production between the two stages. Of these, more than two-thirds showed a change in translation efficiency, but few appeared to be controlled by this alone. Ribosomal proteins were translated poorly, especially in animal-derived parasites. A disproportionate number of metabolic enzymes were up-regulated at the mRNA level in procyclic forms, as were variant surface glycoproteins in bloodstream forms. Comparison with cultured bloodstream forms from another strain revealed stage-specific changes in gene expression that transcend strain and growth conditions. Genes with upstream ORFs had lower mean translation efficiency, but no evidence was found for involvement of uORFs in stage-regulation. Ribosome profiling revealed that differences in the production of specific proteins in T. brucei bloodstream and procyclic forms are more extensive than predicted by analysis of mRNA abundance. While in vivo and in vitro derived bloodstream forms from different strains are more similar to one another than to procyclic forms, they showed many differences at both the mRNA and protein production level.
Sensitivity Analysis of Load-Damping Characteristic in Power System Frequency Regulation

The smart grid initiative leads to growing interests in demand responses and the load models, especially the frequency-sensitive loads such as motors. The reason is that high-penetration controllable load may have substantial impact on system frequency response (SFR). However, the effect of the frequency-related load-damping coefficient is still not completely understood. This paper investigates the effect of frequency-sensitive load on system frequency using typical SFR model. Theoretic analyses based on transfer functions show that the frequency deviation under a different load-damping coefficient is relatively small and bounded when the power system is essentially stable; while the frequency deviation can be accelerated when a power system is unstable after disturbance. For the stable case, the largest frequency dip under a perturbation and the corresponding critical time can be derived by inverse Laplace transformation using a full model considering load-damping coefficient. Further, the error in evaluating the load-frequency coefficient gives the largest impact to frequency deviation right at the time when the largest frequency dip occurs. Multiple-machine cases and automatic generation control (AGC) are also included in the analyses with verifications by simulation studies. The conclusion can be useful for system operators for decision-making of load control or interruption.
Legal Perspectives on School Outcomes Assessment for Students with Disabilities

Assessment of educational results for students with disabilities has been an element of nearly all recent reform, policy, and legislative activities. IDEA '97 includes specific provisions regarding the participation of students with disabilities in general education assessment of student progress at both the district and state levels. Historically, when legal issues regarding the relationship between students with disabilities and outcomes assessments have arisen, courts have said such assessments (e.g., minimum competency, exit exams) are allowable provided the student is provided (a) appropriate accommodations to demonstrate his or her skills and (b) adequate opportunity to learn the subject matter measured by such tests. As newer assessments of progress toward higher learning standards are adopted by districts and states, these issues are likely to be revisited. Additionally, IDEA '97 creates both opportunities and challenges regarding students with disabilities' partial participation in general state ...
Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its γ subunit and transducin

The switching on of the cGMP phosphodiesterase (PDE) in retinal rod outer segments by activated transducin (T alpha-GTP) is a key step in visual excitation. The finding that trypsin activates PDE (alpha beta gamma) by degrading its gamma subunit and the reversal of this activation by gamma led to the proposal that T alpha-GTP activates PDE by relieving an inhibitory constraint imposed by gamma (Hurley and Stryer: J. Biol. Chem. 257:11094-11099, 1982). We report here studies showing that the addition of gamma subunit also reverses the activation of PDE by T alpha-GTP-gamma S. A procedure for preparing gamma in high yield (50-80%) is presented. Analyses of SDS polyacrylamide gel slices confirmed that inhibitory activity resides in the gamma subunit. Nanomolar gamma blocks the activation of PDE by micromolar T alpha-GTP gamma S. The degree of activation of PDE depends reciprocally on the concentrations of gamma and T alpha-GTP gamma S. gamma remains bound to the disk membrane during the activation of PDE by transducin. The binding of gamma to the alpha beta subunits of native PDE is very tight; the dissociation constant is less than 10 pM, indicating that fewer than 1 in 1,700 PDE molecules in rod outer segments are activated in the absence of T alpha-GTP.
Abnormally Increased Power of Breathing as a Complication of Closed Endotracheal Suction Catheter Systems

A closed-suction catheter is situated between the endotracheal tube (ETT) and the Y-piece of the breathing circuit, and thereby remains integrated in the circuit at all times. After suctioning, the catheter is retracted from the ETT into the suction catheter’s protective sleeve and is thus out of the airflow path to and from the ETT and breathing circuit. We report a case where the tip of a closed-suction catheter was inadvertently left in the tracheostomy tube, thereby increasing the patient’s work of breathing (WOB), evidenced clinically only by increased effort to breathe. A 74-year-old man (body weight 68 kg) was admitted to the surgical intensive care unit with sepsis due to an infected aorto-bifemoral artery graft. He was intubated for respiratory failure on admission. The infected arterial graft was resected on hospital day 2, following an axillo-femoral artery bypass. His hospital course was further complicated by ischemia of the sigmoid colon, treated with sigmoid colectomy, end-colostomy, and a Hartmann’s pouch. He had a tracheostomy (7.0-mm inner-diameter tracheostomy tube) performed on hospital day 21 because of ongoing surgical problems requiring mechanical ventilation.
Integration in natural resources education: Designing a core curriculum

The field of natural resources is in a strong position to build a more integrated and holistic component into its system of higher education. This article describes an effort by the faculty of the School of Natural Resources at the University of Vermont to design and implement a core curriculum that integrates the traditional fields of study in natural resources and the natural and social sciences. Important elements of this curriculum design process include the notion of competence, literacy, or fluency in natural resources, a systems model of higher education, a series of faculty workshops, and several partnerships and collaborative arrangements. The result of this project is an integrated core curriculum comprised of seven primary courses and related modules.
Hypolipidemic activity and toxicity of 3-methoxy-N,N'-diaminophthalamide in rodents.

3-Methoxy-N,N′-diaminophthalamide was observed to be a potent hypolipidemic agent in rodents. Serum cholesterol and triglyceride levels in rats were significantly reduced as were lipid contents of the liver, small intestine, and aorta wall. VLDL and LDL cholesterol levels were significantly reduced. Unfortunately, HDL cholesterol levels were also markedly reduced. Furthermore, acute toxicity studies showed that the compound caused marked increases in serum CP kinase activity with doses of 40 and 100 mg/kg/day in mice. This is not a property of the 2,3-dihydrophthalazine-1,4-dione, the resultant product of the N,N′-diaminophthalamides. Apparently, closing the ring results in a safer compound with elevations in HDL cholesterol levels, a desirable characteristic in effective hypolipidemic agents. Lipidsenkende Wirksamkeit und Toxizitat von 3-Methoxy-N,N′-diaminophthalamid bei Nagern 3-Methoxy-N,N′-diaminophthalamid senkt die Blutfettwerte bei Nagern deutlich. Serumcholesterol- und -triglyceridspiegel bzw. die Lipid-Spiegel der Leber, des Dunndarms und der Aortenwande werden signifikant erniedrigt. VLDL- und LDL-Cholesterolspiegel werden deutlich gesenkt, nicht aber die HDL-Cholesterolspiegel. - Nach Studien zur Akuttoxizitat erhoht die Titelverbindung in Dosen von 40 bzw. 100 mg/kg/Tag bei Mausen die Serum-CP-Kinase im Gegensatz zum entspr. 2,3-Dihydrophthalazin-1,4-dion, das aus der Titelverbindung hergestellt wird. Dieser Ringschlus fuhrt zu einer sichereren Verbindung, die HDL-Cholesterol erhoht: ein wunschenswerter Effekt bei Lipidsenkern.
Qualitative Health Research

PART ONE: THE CHARACTERISTICS OF QUALITATIVE RESEARCH The Disease of Masturbation - H Tristam Engelhardt Jr Values and the Concept of Disease Shakespeare in the Bush - Laura Bohannan Context as a Source of Meaning and Understanding - Pamela S Hinds, Doris E Chaves and Sandra M Cypess The Holistic Injunction - George W Noblit and John D Engel An Ideal and a Moral Imperative for Qualitative Research 'Euch, Those Are For Your Husband!' - Janice M Morse Examination of Cultural Values and Assumptions Associated with Breast-Feeding PART TWO: THE QUALITATIVE SYNTHESIS OF RESEARCH The Research Topic - Arnold van Gennep Or, Folklore Without End Comparative Analysis of Conceptualizations and Theories of Caring - Janice M Morse et al PART THREE: PHENOMENOLOGY Birthing Pain - Vangie Kelpin Operating on a Child's Heart - Stephen J Smith A Pedagogical View of Hospitalization Memories of Breathing - Monica Clarke A Phenomenological Dialogue Asthma as a Way of Becoming PART FOUR: ETHNOGRAPHY The Meaning of Menopause in a Newfoundland Fishing Village - Dona Lee Davis On Control, Certitude and the 'Paranoia' of Surgeons - Joan Cassell Under the Guise of Passivity - Hava Golander We Can Communicate Warmth, Caring and Respect On Being Sane in Insane Places - D L Rosenhan PART FIVE: ETHNOSCIENCE Beating the Drunk Charge - James P Spradley The Structure and Function of Gift Giving in the Patient-Nurse Relationship - Janice M Morse PART SIX: GROUNDED THEORY Becoming Ordinary - Beverley Lorencz Leaving the Psychiatric Hospital The Emotional Experience of Breast Expression - Janice M Morse and Joan L Bottorff Negotiating Commitment and Involvement in the Nurse-Patient Relationship - Janice M Morse PART SEVEN: THE SEMISTRUCTURED QUESTIONNAIRE Social Coercion for Weaning - Janice M Morse and Margaret J Harrison
Brief report: Measuring self‐efficacy with female adolescents who are conduct disordered: Validation of the program efficacy scale

This study focused on measuring self-efficacy with 44 female conduct disordered youth involuntarily placed in a long-term residential setting. The Program Efficacy Scale (PES) was developed as a measure of self-efficacy linked specifically to program completion. Construct validity for this measure was assessed by correlating it to the Generalized Self-Efficacy Scale (GSE) developed by Tipton and Worthington (1984) and other measures of program success. The PES was found to be significantly related to the GSE, length of placement, level of program achievement, and effort ratings by staff. Possible uses for the PES in predicting success or failure with youth in residential settings are discussed.
Algebraic Matrix Groups

We now start afresh to consider the subject from a different viewpoint. Again we begin by looking at the solutions of sets of equations, but we consider only a fixed field k. We call a subset S of k n closed if it is the set of common zeros of some polynomials {f i } in k[x1,…,X n ]. Clearly an intersection of closcd sets is closed. Also, if S is the zeros of {f i } and T the zeros of {g j }} then S ∪ T is the zeros of {f i g j }, so finite unions of closed sets are closed. Thus we have a topology, the Zariski topology on k n .
Quantization of the yang-mills field in the null-plane frame

The massless Yang-Mills field is quantized in the null-frame gauge ${A}_{\ensuremath{-}}^{a}=0$, and Feynman rules are derived.
A body-force based method to generate supersonic equilibrium turbulent boundary layer profiles

Abstract We further develop a simple counterflow body force-based approach to generate an equilibrium spatially developing turbulent boundary layer suitable for Direct Numerical Simulations ( DNS ) or Large Eddy Simulations ( LES ) of viscous–inviscid interactions. The force essentially induces a small separated region in an incoming specified laminar boundary layer. The resulting unstable shear layer then transitions and breaks down to yield the desired unsteady profile. The effects of wall thermal conditions are explored to demonstrate the capability of the method for both fixed wall and adiabatic wall conditions. We then describe an efficient method to select parameters that ensure transition by examining precursor signatures using generalized stability variables. These precursors are shown to be evident in a computational domain spanning only a small region around the trip and can also be detected using 2D simulations. Finally, the method is tested for different Mach numbers ranging from 1.7 to 2.9, with emphasis on flow field surveys, Reynolds stresses, and energy spectra. These results provide guidance on boundary conditions for desired boundary layer thickness at each Mach number. The consequences of using a much lower Reynolds number in computation relative to experiment are evident at the higher Mach number, where a self sustaining turbulent boundary layer is more difficult to obtain.
Evolution of the National Meteorological Center Global Data Assimilation System: January 1982–December 1983

Abstract A number of changes were made to the National Meteorological Center global data assimilation system (GDAS) during 1982 and 1983. The most significant of these changes was the replacement of the quasi-univariate, sigma-coordinate optimum interpolation analysis procedure by a version that performs a fully multivariate analysis on mandatory pressure surfaces. The new analysis technique is described in some detail. The impact of this and other changes made during 1982 and 1983 on the performance of the GDAS is evaluated.
Fatty Acids: Trans Fatty Acids

The data supporting a negative effect of dietary trans -fatty acids on cardiovascular disease risk are consistent. The primary dietary sources of trans -fatty acids include partially hydrogenated fat and rudiment fat. The adverse effect of trans -fatty acids on plasma lipoprotein profiles is consistent; their effect on other cardiovascular risk factors is less clear. Observational data demonstrate an adverse effect of trans -fatty acids/partially hydrogenated fat on cardiovascular disease risk. Recent worldwide trends in the National Diet and Nutrition Survey suggest variable trends in trans -fatty acid intake, with lower intakes in Western Europe and Scandinavia and higher intakes in Africa, the Middle East, and South Asia.
Improving Rolling Element Bearing Thermal Compliance Through In Situ Cooling

In this study a novel in situ rolling element bearing (REB) lubricant cooling system is developed that provides a continuous cooling of the bearing outer race. In the design the stationary outer race is expanded to accommodate a cooling coil for the continuous cooling of the lubricant and the outer race. Water is used as the coolant While Amsoil 75W-90 Severe Gear® oil is used as a lubricant. Heat generated during the test run is removed by the coolant flowing through the cooling coil. The tribological effects at the speeds of the cooling test were evaluated using block-on-ring tribometer tests. Results from the experiments indicate that in the absence of cooling the temperature of the bearing outer race rises while cooling dramatically lowers the temperature. Also, the coefficient of friction increases with increasing speed. As such, in situ cooling that leads to reduced operational temperature minimizes lubricant degradation that can result from uncontrolled frictional heating.Copyright © 2011 by ASME
Feasibility of a Modified Biopsy Needle for Irreversible Electroporation Ablation and Periprocedural Tissue Sampling.

Objectives:To test the feasibility of modified biopsy needles as probes for irreversible electroporation ablation and periprocedural biopsy.Methods:Core biopsy needles of 16-G/9-cm were customized to serve as experimental ablation probes. Computed tomography-guided percutaneous irreversible electroporation was performed in in vivo porcine kidneys with pairs of experimental (n = 10) or standard probes (n = 10) using a single parameter set (1667 V/cm, ninety 100 µs pulses). Two biopsy samples were taken immediately following ablation using the experimental probes (n = 20). Ablation outcomes were compared using computed tomography, simulation, and histology. Biopsy and necropsy histology were compared.Results:Simulation-suggested ablations with experimental probes were smaller than that with standard electrodes (455.23 vs 543.16 mm2), although both exhibited similar shape. Computed tomography (standard: 556 ± 61 mm2, experimental: 515 ± 67 mm2; P = .25) and histology (standard: 313 ± 77 mm2, experimental: 27...
Data) STRUCTURES

We show that a large fraction of the data-structure lower bounds known today in fact follow by reduction from the communication complexity of lopsided (asymmetric) set disjointness! This includes lower bounds for: (a) high-dimensional problems, where the goal is to show large space lower bounds; (b) constant-dimensional geometric problems, where the goal is to bound the query time for space O(n polylg n); (c) dynamic problems, where we are looking for a trade-off between query and update time. (In this case, our bounds are slightly weaker than the originals, losing a lglg n factor.) Our reductions also imply the following new results: (a) an Omega(lg n / lg lg n) bound for 4-dimensional range reporting, given space O(n ldr poly lg n). This is very timely, since a recent result [Nekrich, SoCG'07] solved 3D reporting in near-constant time, raising the prospect that higher dimensions could also be easy; (b) a tight space lower bound for the partial match problem, for constant query time.(c) the first lower bound for reachability oracles.
Acne and its management.

1. S. Alison Basak, MD, MA* 2. Andrea L. Zaenglein, MD*,† 1. *Department of Dermatology, Penn State Hershey Medical Center, Hershey, PA. 2. †Department of Pediatrics, Penn State Hershey Medical Center, Hershey, PA. * Abbreviations: DHEAS: : dehydroepiandrosterone sulfate FDA: : Food and Drug Administration FSH: : follicle-stimulating hormone LH: : luteinizing hormone OTC: : over the counter Acne is the most common skin disorder in the United States, affecting approximately 85% of young people between 12 and 24 years of age. Critical components to diminish physical and psychological concerns and lessen the potential for permanent sequelae include correct choice of therapy, and promotion of adherence to therapeutic regimens by educating patients regarding expected adverse effects, realistic expectations for improvement and the importance of maintenance regimens. After completing this article, readers should be able to: 1. Diagnose different types of acne lesions and assess severity. 2. Recognize and correct common misconceptions about acne held by patients and their parents. 3. Prescribe appropriate therapy according to the patient’s clinical presentation. 4. Educate patients regarding the expected course and potential adverse effects of therapies. Acne vulgaris (acne) is the most common skin disorder in the United States. (1)(2) The severity can vary from mild comedonal acne to fulminant systemic disease that affects multiple organ systems. Acne often is a cause of permanent scarring, emotional distress, and decreased self-esteem, which has led to the development of a multibillion dollar industry of medications, beauty products, and procedures that target individuals with acne. (3) Highly effective treatments are available, so familiarity with the diagnosis and management of this condition is essential for virtually all health care professionals. Acne vulgaris affects 40 million to 50 million individuals each year in the United …
ATPS-14KETOGENIC DIET-INDUCED INCREASE IN MCT1 FACILITATES KETONE BODY OXIDATION IN RAT GLIOMAS

The dependence of brain tumor cells on glucose is the target of the ketogenic diet (KD), which creates a plasma nutrient profile similar to fasting: increased levels of ketone bodies and reduced plasma glucose concentrations. The use of KDs as therapy has been of particular interest for brain tumors because they reportedly cannot oxidize ketone bodies and therefore would be starved. However, in vivo studies assessing the ability of tumors to oxidize ketone bodies are lacking. We investigated ketone body oxidation in vitro and vivo using 13C magnetic resonance spectroscopy in combination with infusion of the 13C-labeled ketone body, beta-hydroxybutyrate (BHB) in two rodent glioma models (9L & RG2). The detection of 13C in glutamate following the infusion of [2,4-13C]-BHB was the primary outcome parameter and proof of oxidative 13C-BHB metabolism in the rat gliomas. Steady-state metabolic modeling was applied to further characterize the 13C-BHB metabolism. The level of glutamate 13C-labeling and 13C-BHB oxidation in 9L and RG2 rat gliomas was similar to that of contralateral brain. In addition, when glioma-bearing animals were fed a KD, immunohistochemistry showed that the ketone body transporter MCT1 was upregulated, facilitating uptake and doubling oxidation of ketone bodies in gliomas. These results demonstrate that rat gliomas can easily oxidize ketone bodies and indicate an adaptation through upregulation of ketone body transport when fed a KD. These data are not supporting the hypothesis that brain tumors are metabolically inflexible. Furthermore, there are indications that KDs in humans could also induce an increase in MCT1. MCT1 is a drug target for which an inhibitor is currently investigated in a clinical trial. Overall, these results indicate that the use of KDs as therapy targeting brain tumor metabolism and the effect of such diets on MCT1 needs further investigation, particularly in patients.
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis

We report two series of novel cephalosporins that are bactericidal to Mycobacterium tuberculosis alone of the pathogens tested, which only kill M. tuberculosis when its replication is halted by conditions resembling those believed to pertain in the host, and whose bactericidal activity is not dependent upon or enhanced by clavulanate, a β-lactamase inhibitor. The two classes of cephalosporins bear an ester or alternatively an oxadiazole isostere at C-2 of the cephalosporin ring system, a position that is almost exclusively a carboxylic acid in clinically used agents in the class. Representatives of the series kill M. tuberculosis within macrophages without toxicity to the macrophages or other mammalian cells.
A nalysis of Transcriptional Control Mechanisms I

Transcriptional control, the process controlling when and how much RNA is produced from a DNA template, is a major determinant of gene expression in eukaryotic cells. This process, intensely studied over the last few decades, is under control of specific DNA sequences (cis elements) that function by virtue of their ability to be recognized by sequence-specific DNA-binding proteins (trans-acting elements). Both of these elements function in concert to control the rate and location of RNA transcript formation. Therefore, identification of these cis- and trans- acting elements provides important mechanistic insight into gene expression control. These studies are relevant to understanding aspects of the renin-angiotensin system. For example, a large body of evidence has shown that angiotensinogen (AGT) is a highly inducible gene, regulated by a variety of physiological hormone systems. Because AGT circulates close to its Michaelis-Menten constant (Km) for renin, changes in AGT concentration influence the long-term activity of the RAS [Reviewed in (1)].
Behavioural Science: Culture and climate action

Moderating the impacts of climate change is a global problem. Research now shows that cultural values determine whether personal environmental concerns actually lead to pro-environmental action.
Energy in Early Human Economies

To chemists Frederick Soddy and William Ostwald, anthropologist Leslie White, archeologist Joseph Tainter, historian John Perlin, systems ecologist Howard T. Odum, sociologist Frederick Cottrell, economist Nicolas Georgescu-Roegen, energy scientist Vaclav Smil and a number of others in these and other disciplines, human history, including contemporary events, is essentially about the history of how humans have exploited energy and the technologies they have used to do so.
Electronic Teaching Resources Editor

(2000). Electronic Teaching Resources Editor. Marketing Education Review: Vol. 10, No. 1, pp. VII-VII.
Abstract A07: Methylation of RARB in prediagnosis benign tissue and risk of disease progression in men subsequently diagnosed with prostate cancer

We previously reported results from a case-control study nested in a large hospital-based cohort of men identified over a 12-year period (1990-2002) that gene promoter hypermethylation in histopathologically benign prostate specimens is a marker of prostate cancer risk (Tang et al. J Urol 2013). Whether methylation in pre-diagnostic benign prostate tissue can also predict subsequent disease prognosis has not been studied. Therefore, we estimated hazard ratios (HRs) for biochemical recurrence (BCR), defined as two successive prostate-specific antigen increases after definitive treatment, associated with methylation status of the two genes we found associated with prostate cancer risk: retinoic acid receptor-β (RARB) and adenomatosis polyposis coli (APC). Follow-up data were from a subset of the cases (n=394) that were part of our aforementioned nested prostate cancer case-control study of gene promoter methylation status of five genes measured in pre-diagnostic benign biopsy specimens. Overall, after adjusting for known clinical risk factors for prostate cancer progression (advanced grade, advanced stage, high prostate-specific antigen (PSA)), neither methylation of the APC or the RARB genes was associated with a significantly increased risk of BCR, but risk associated with RARB methylation was elevated (HR=1.30; 95% CI= 0.93-1.83). This risk was higher in Whites (HR=1.44; 95% CI= 0.92-2.25) compared with African Americans (HR=1.22; 95% CI= 0.71-2.12), but differences by race were not significant. In additional stratified analyses, we found that while associations with APC methylation did not differ between strata, RARB methylation showed significantly increased risk of BCR in specific substrata; specifically men with high PSA at time of diagnosis (HR=1.73; 95% CI=1.13–2.64) and men in whom methylation did not occur in the four other genes under study (HR=1.82; 95% CI=1.14–2.93). In conclusion, we show for the first time that methylation events occurring before onset of prostate cancer may predict the course of subsequent cancer in defined patient groups. These findings may have important clinical decision making implications in terms of both identifying aggressive prostate cancer at its earliest stages and also avoiding unnecessary additional diagnostic biopsies. Citation Format: Benjamin Rybicki, Michelle Jankowski, Kieu Do, Dhananjay Chitale, Sheri Trudeau, Andrew Rundle, Steven Belinsky, Deliang Tang. Methylation of RARB in prediagnosis benign tissue and risk of disease progression in men subsequently diagnosed with prostate cancer. [abstract]. In: Proceedings of the Thirteenth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2014 Sep 27-Oct 1; New Orleans, LA. Philadelphia (PA): AACR; Can Prev Res 2015;8(10 Suppl): Abstract nr A07.
Modeling player decisions in a supply chain game

Player decision modeling can provide useful guidance to understand player performance in serious games. However, current player modeling focuses on high-level abstraction of player behavior rather than decision-level player modeling, and is predominantly applied to entertainment games. In this paper, we describe an approach from game design to data mining and data analysis to determine detailed player decision patterns. We illustrate this approach with VistaLights, a supply chain game we developed based on a recent oil spill event in Houston. With this game, we set up a within-subjects experiment to study decision making under varying circumstances, specifically to consider whether/how a recommendation system can improve human decisions. Using a series of data analysis techniques we built a coarse-grained decision model as well as a fine-grained model to compare players' actions on the game outcomes. The results confirm the need for decision-level modeling and show an ability of our approach to both identify the good and bad decision patterns among players.
Multidimensional Toeplitz operators with locally sectorial symbols

ABSTRACTWe study a class of Toeplitz operators with discontinuous symbols, stimulated by classical work of R. Douglas and H. Widom. We extend the notion of a locally sectorial symbol from the setting of scalar Toeplitz operators on the circle to systems, acting on sections of vector bundles over a class of multidimensional domains with minimal smoothness, known as uniformly rectifiable domains, and establish Fredholm properties in this expanded setting.
Sampling technique affects detection of habitat factors influencing wild bee communities

Reliable and consistent monitoring is essential for bee conservation. Correctly interpreting the influence of habitat characteristics on native bee communities is necessary to develop effective strategies for bee conservation and to support the provision of pollination services to agricultural crops or natural plant communities. Biases imposed by different sampling methods used to monitor bee populations can affect our ability to discern important habitat characteristics, but the extent of this bias is not well understood. We used three common sampling methods (blue vane traps, colored pan traps, and aerial net collection) to assess bee communities in fragments of Palouse Prairie in eastern Washington and northern Idaho. We determined differences in abundance, species richness, proportional representation of different genera, and functional trait characteristics among the three sampling techniques. We also evaluated differences in the relationships between bee species richness and diversity and two key habitat variables known to mediate bee populations: local plant species richness and the amount of suitable bee habitat in the surrounding landscape. Community metrics for bees collected using blue vane traps were correlated with the amount of suitable habitat in the landscape but not with plant species richness. Conversely, community metrics for bees collected using an aerial net were correlated with the local plant species richness but not with the amount of suitable habitat. Our results indicate that effective conservation of insect communities will require a combination of sampling methods to reliably discern the influence of habitat variables at different scales and across taxa with varying functional traits.
Exploring the supersymmetric U (1 ) B -L ×U (1 ) R model with dark matter, muon g - 2 , and Z ' mass limits

We study the low scale predictions of the supersymmetric standard model extended by $U(1{)}_{B\ensuremath{-}L}\ifmmode\times\else\texttimes\fi{}U(1{)}_{R}$ symmetry, obtained from $SO(10)$ breaking via a left-right supersymmetric model, imposing universal boundary conditions. Two singlet Higgs fields are responsible for the radiative $U(1{)}_{B\ensuremath{-}L}\ifmmode\times\else\texttimes\fi{}U(1{)}_{R}$ symmetry breaking, and a singlet fermion $S$ is introduced to generate neutrino masses through an inverse seesaw mechanism. The lightest neutralino or sneutrino emerge as dark matter candidates, with different low scale implications. We find that the composition of the neutralino lightest supersymmetric particle (LSP) changes considerably depending on the neutralino LSP mass, from roughly half $U(1{)}_{R}$ bino, half minimal supersymmetric model (MSSM) bino, to a singlet higgsino, or completely dominated by the MSSM higgsino. The sneutrino LSP is statistically much less likely, and when it occurs it is a 50-50 mixture of right-handed sneutrino and the scalar $\stackrel{\texttildelow{}}{S}$. Most of the solutions consistent with the relic density constraint survive the XENON 1T exclusion curve for both LSP cases. We compare the two scenarios and investigate parameter space points and find consistency with the muon anomalous magnetic moment only at the edge of a $2\ensuremath{\sigma}$ deviation from the measured value. However, we find that the sneutrino LSP solutions could be ruled out completely by the strict reinforcement of the recent ${Z}^{\ensuremath{'}}$ mass bounds. We finally discuss collider prospects for testing the model.
US arts support in the Trump era

The FY 2018 Budget released by the Trump White House in late May 2017 proposes slashing funding to 18 federal agencies and to a wide range of domestic and international programs, including those th...
Back Squat Potentiates Both Vertical and Horizontal Jump Performance in Collegiate Ice Hockey Players

Background: Back squats (BSQ) have been shown to transiently improve performance in explosive vertical movements such as the vertical jump (VJ). Still, understanding of this phenomenon, termed post-activation potentiation (PAP), remains nebulous as it relates to explosive horizontal movements. Objective: Therefore, the purpose of the present investigation was to assess whether heavy BSQ can potentiate both VJ and horizontal jump (HJ) performance. Method: Nine male ice hockey players from the Long Beach State ice hockey team performed five testing sessions separated by 96-hours. The first testing session consisted of a one repetition maximum (1-RM) BSQ to determine subsequent testing loads. The four subsequent testing sessions, which were randomized for order, consisted of five repetitions of BSQ at 87% 1-RM followed by horizontal jump (BSQ-HJ), five repetitions of BSQ at 87% 1-RM followed by vertical jump (BSQ-VJ), horizontal jump only (CT-HJ) and vertical jump only (CT-VJ). During the potentiated conditions, rest intervals were set at five minutes between the BSQ and either VJ or HJ. Alpha-level was set a priori at 0.05. Results: The results indicate that both vertical (p=0.017) and horizontal (p=0.003) jump were significantly increased (VJ= +5.51cm, HJ= +11.55cm) following a BSQ. Conclusion: These findings suggest that BSQ may improve both vertical and horizontal jump performance in athletes who participate in sports emphasizing horizontal power, such as ice hockey.
An application of participatory action research in advising-focused learning analytics

Advisors assist students in developing successful course pathways through the curriculum. The purpose of this project is to augment advisor institutional and tacit knowledge with knowledge from predictive algorithms (i.e., Matrix Factorization and Classifiers) specifically developed to identify risk. We use a participatory action research approach that directly involves key members from both advising and research communities in the assessment and provisioning of information from the predictive analytics. The knowledge gained from predictive algorithms is evaluated using a mixed method approach. We first compare the predictive evaluations with advisors evaluations of student performance in courses and actual outcomes in those courses We next expose and classify advisor knowledge of student risk and identify ways to enhance the value of the prediction model. The results highlight the contribution that this collaborative approach can give to the constructive integration of Learning Analytics in higher education settings.
Structural changes of gastric mucosa in patients with intestinal metaplasia and nitrogen oxide hyperproduction

Мета: проаналізувати структурні зміни слизової оболонки шлунка та оцінити роль системи оксиду азоту в цих процесах у пацієнтів iз хронічним гастритом та кишковою метаплазією. Матеріали та методи. Морфологічне дослідження проводилося в 38 пацієнтів iз хронічним гастритом та атрофією, локальною (антральний відділ шлунка) або дифузною кишковою метаплазією. Концентрація оксиду азоту була визначена у вмісті шлунка та в крові всіх пацієнтів. Результати. Морфометричне дослідження показало помітне зниження (до (0,12 ± 0,04) %) ядерно-цитоплазматичного співвідношення в пацієнтів iз кишковою метаплазією порівняно з тими, хто мав атрофію. Еліптичність ядер клітин також зменшувалася з розвитком кишкової метаплазії та в пацієнтів без метапластичних змін дорівнювала (0,76 ± 0,04) %, у випадках локальної кишкової метаплазії — (0,65 ± 0,11) %, при дифузнiй метаплазії — (0,41 ± 0,12) %. Встановлено, що у хворих iз кишковою метаплазією, локалiзованою в антральному відділі, рівень оксиду азоту в шлунковому соку збільшується і на 24–65 % перевищує контрольну величину. Розглянуто можливий механізм загибелі клітин слизової оболонки шлунка внаслiдок апоптозу та некрозу в умовах гіперпродукції оксиду азоту. Висновки. Iнгібуючий ефект оксиду азоту на шлункову секрецію реалізується за рахунок його стимулюючого впливу на активність циклооксигенази та синтезу простагландинів.
The WKB Approximation

The WKB method, named for Gregor Wentzel, Hendrik Kramers, and Leon Brillouin, gives an approximation to the eigenfunctions and eigenvalues of the Hamiltonian operator \(\hat{H}\) in one dimension.
Using Formatted Sequential Access and Internal Files

This chapter discusses the concept of a formatted text file and presents the syntax of the OPEN, READ, WRITE, and CLOSE statements required to access and create such files. The important scenario in which a READ statement appears in a conditional loop structure to control the reading of a data file of unknown length is discussed in detail. The syntax for writing formatted files is described. Internal files are presented as a way to store records in a temporary buffer for processing.
Physical Activity Patterns and Mortality: The Weekend Warrior and Activity Bouts.

PURPOSE This study aimed to examine how accelerometer-assessed physical activity accumulation patterns (e.g., is activity performed daily or only 1 or 2 d·wk or is activity accrued in bouts) may affect the association with mortality. METHODS Adults (N = 3438), age 40 yr and older, who wore an accelerometer (ActiGraph 7164), were drawn from the longitudinal follow-up of the National Health and Nutritional Examination Survey (2003-2006), a population-based survey of the United States. Accelerometer-assessed moderate-to-vigorous physical activity (MVPA) was described by activity patterns. Participants engaging in the majority of their activity on only 1 or 2 d·wk· were classified as "weekend warriors." Activity bouts were defined as a period of at least moderate intensity lasting at least 10 min. Bout characteristics included bout frequency and length. Mortality was assessed through National Death Index matching through 2013. Mortality rates were compared among groups with different activity patterns. RESULTS Over an average follow-up of 77.4 months, 394 deaths occurred. Compared to participants with <37.5 min of MVPA per week, those with greater amounts of activity had a 60% to 69% mortality rate reduction after adjusting for relevant covariables. Similar risk reductions were found when contrasting weekend warriors with those who were more frequently active. An increase of one MVPA bout per week was associated with a 13% increased mortality rate. Bout duration was not associated with mortality. CONCLUSION Physical activity is associated with decreased mortality rate, even among those who are active 1 or 2 d·wk.
A comparison of fixation methods in adolescent patients with diaphyseal forearm fractures.

Abstract Introduction The purpose of this study was to compare both bone diaphyseal forearm fractures in adolescent patients treated with plate fixation to patients treated with intramedullary fixation to identify differences in complications and outcomes. Materials & methods A retrospective study was performed on all adolescent patients with age between 10 and16 year and treated with intramedullary fixation or plate fixation for a diaphyseal both bone forearm fracture between 2005 and 2014. Demographic information and clinical data was collected. Radiographs were reviewed to evaluate post-operative radial bow magnitude and location, time to union, and residual angulation. Complications were graded using the modified Clavien-Dindo Classification system. Results A total of 102 patients met the inclusion criteria. Of these, 32 were treated with plate fixation and 70 with intramedullary fixation. The intramedullary nail group had 55% of complications classified as major. There were no major complications in the plate fixation group (P = 0.1). The radial bow was significantly more distal and smaller in magnitude in the intramedullary fixation group (P Conclusion Diaphyseal forearm fractures in adolescent patients remain challenging injuries to treat. Forearm bony anatomy is not completely restored with intramedullary fixation. Results suggested an association towards increased complication rates and complication severity with intramedullary fixation. Level of evidence Level 3 retrospective comparative study
In Situ Investigation of Pt–Rh Thermocouple Degradation by P-Bearing Gases

Gases bearing elements such as As, S, and Si are known to degrade Pt and Pt–Rh alloys, leading to thermocouple sensor failure during industrial operations. While the corrosive impact of As, S, and Si gases have been discussed in the literature, the impact of P has not been well studied. P may originate from the carbon feedstock, ores, additives, and refractory bricks used in metallurgical and gasification processes. In this work, gaseous P interactions with Pt–Rh (Rh = 6 and 30 wt%) alloys were isothermally investigated at 1012° C in situ using a customized environmental white light/confocal scanning laser microscope. Changes in microstructure and P-diffusion into the Pt–Rh alloys are discussed based on real-time images recorded during the exposure tests and electron probe microscopy analysis from the quenched samples.
Looking for Pei Lim's penis: melancholia, mimicry, pedagogy

ABSTRACTThis article considers the salience of Freud’s account of melancholia – one that points to the constitutive role of loss in subject formation – for understanding the racialization of queer sexuality and its mediation in pornography. Scholars have long and insightfully demonstrated the value of melancholia as an interpretive lens for making sense of the dynamics of racialization in the context of the contradictions of liberalism in the Global North. Taking cues from such work, I seek here to trace how pornography might stage returns to inaugural scenes of repudiated desire, and how it might proffer insight into the specificities of racial melancholia for queers. To illuminate the potential of constitutive loss for thinking about race in queer porn, I turn to the figure of Lim Pei-Hsien, an artist, activist, and porn star with a storied but rarely acknowledged history in Canadian LGBTQ, AIDS, and anti-racist circles. I argue that sustained engagement with Lim’s work positions him as a profoundly and...
Coconstructing Social Reality

In this chapter we continue the societal interpretation of the children’s social pretend play, “The Royal Ball,” described in Chapter 1. This time we focus on the play as a spontaneous coconstruction of shared realities and ask questions about the different modes of these realities. Elaborating on Goffman’s (1974) concept of frame analysis, we introduce a coding scheme for pretend play in which we distinguish the categories of sense and reference. This coding scheme is applied to the discourse of the entire play session. In contrast to an assumed simple pretense-reality dichotomy, our analysis specifies a rich spectrum of reality modes, from deeply engrossed play actions to nonplay interactions. The interweaving of the different reality modes is shown to carry the in-frame play theme to completion, even as concerns of interpersonal power continually impel the children’s interactions partly or fully out-of-frame. Where previously we pointed out general societal features in the girl’s play, here we document the remarkable dramatic quality of their reality construction. In conclusion, the theoretical view of the preceding chapter is advanced regarding the society-instituting function of pretense and imaginary play.
Effect of Reminiscence on Learning Selected Badminton Skills

Abstract This study investigated the effects of the degree of original learning and the length of two nonpractice periods on reminiscence in badminton. Two groups were used, one having 6 weeks of instruction, the other 9 weeks. The nonpractice periods were 6 weeks and 12 weeks. The wall volley and short serve tests were given at the beginning and end of the instructional periods and at the end of each nonpractice period. Reminiscence did occur in the wall volley skill during the first nonpractice interval for the group having 9 weeks of instruction and during the second nonpractice interval for the group having 6 weeks of instruction. Reminiscence did not occur for either group on the short serve skill.
Two Editors Reflect on Women and Therapy in the 1980s and 1990s

AbstractEsther Rothblum and Ellen Cole were coeditors of Women & Therapy from 1984-1995. In this article we describe the process of editing a feminist journal in the 1980s and 1990s, including how ...
Writing in wartime China: Chongqing, Shanghai, and Southern Zhejiang

The outbreak of the full-scale Sino-Japanese War (1937–1945) brought an end to the printing and publishing industry centered in Shanghai in the 1930s. Chongqing then emerged as a nerve center of in...