cssi/SciSciGPT-SciSciNet huggingface dataset:
Procedures for Radioactive I-125 Seed Implants

Typical safety procedures and guidelines for the use of radioactive I-125 seed implant are presented. Topics covered include: Physical properties, management and planning of I-125, source logging, source transportation, source accounting during and after implant, room monitoring, recording, dosimetry films, nursing procedures, discharge of patient. These guidelines have been found to be of practical value for personnel involved with the implant to ensure compliance with the regulations, but are not necessarily the only procedures that could be utilized.
Improved Mechanical Property and Water Resistance of Zein Films by Plasticization with Tributyl Citrate

Pure zein film is intrinsically rigid and brittle and lacks necessary mechanical properties for industrial processing. In addition, pure zein film is sensitive to high relative humidity, which limits its application in food packaging. To improve these properties, tributyl citrate (TBC) was incorporated into zein film to the mass ratios from 10% to 50%. A significant decrease in Young's modulus was observed, from 409.86 MPa in pure zein films to 136.29 MPa in zein films with 50% TBC. Among all films, those containing 10% TBC are most flexible and toughest. Both DSC and microscopy methods suggested that the TBC may be loaded up to 20% to avoid microsized phase separation. Through modeling with experimental data, incorporating 50% TBC reduced the water absorption capacity to 12.94% compared to 31.78% by pure zein film. More importantly, the integrity of zein/TBC film was maintained at high relative humidity and even after immersion in water. However, more than 20% TBC in zein films led to microsized phase separation, which was harmful to mechanical properties.
Leafhopper and Planthopper Populations on Eight Irrigated Grasses Grown for Livestock Forage

Seven leafhoppers and a planthopper, Delphacodes campestris (Van Duzee), occurred on all 8 cool-season grasses but densities were significantly different on different hosts. Endria inimica (Say) was the most abundant leafhopper on all grasses but preferred Bromus inermis Leyss. and, B. albidus M.B. Psammotettix alienus (Dahlbom) was most abundant on Bromus spp. and Phalaris arundinacea L. P. lividellus (Zetterstedt) and Macrosteles fascifrons (St´l) preferred Alopecurus arundinaceus Poir. Exitanus exitiosus (Uhler) was most abundant on Agropyron intermedium (Host) Beauv. and Elymus junceus Fisch; Forcipata loca Delong & Caldwell on Dactylis glomerata L., Festuca arundinacea Schreb. and A. arundinaceus . Balclutha abdominalis (Van Duzee) did not exhibit significant host preferences. D. campestris was most abundant on A. intermedium , E. junceus , and F. arundinacea . Relative abundance of several leafhoppers varied seasonally on different hosts. Nonpreferred hosts tended to have highest leafhopper populations in the spring.
Antiepileptic drug therapy in younger patients: when to start, when to stop.

SUMMARY Decisions about whether and how long to treat seizures in children and adolescents should be based on rational criteria and knowledge of the natural history of epileptic syndromes, rather than on the presumption that all seizures should be treated at any cost.
The effects of Cendehill rubella vaccine in children under unusually complicated circumstances.

The preparation of Cendehill strain of rubella virus had been tested for safety both in vitro and in vivo, and had been lyophilized; each vial contained lO3-7 plaque-forming units (PFU) in RK13 cells. It was made by Recherche et Industrie Therapeutiques (RIT) in Belgium and furnished by the Smith, Kline and French Company. Study population. Children living at the Nazareth Child Care Center in Boston, Massachusetts, and ranging in age from 2 to 15 years, were housed in 8 cottages, on the basic of age and sex.
A review of the Geomydoecus tolucae complex (Mallophaga: Trichodectidae) from Thomomys (Rodentia: Geomyidae), based on qualitative and quantitative characters.

Geomydoecus tolucae is redescribed and illustrated; its known host range is 5 subspecies of Thomomys umbrinus from the Mexican states of Puebla. Veracruz, and Mexico. Four new species and subspecies of Geomydoecus are described from Arizona (USA) and Mexico: G. fulvi from T. bottae fulvus from Arizona; G. chihuahuae chihuahuae from 4 subspecies of T. umbrinus and T. bottae from Chihuahua and Arizona (type-host: T. u. madrensis); G. chihuahuae emersoni from T. u. chihuahuae from Durango and southern Chihuahua; and G. pattoni from T. u. chihuahuae from Durango. Distinctions between these taxa are shown using qualitative and quantitative characters and principal components analysis of quantitative characters. Discriminant functions for 2 or 3 characters are provided in instances where they are shown to offer enhanced differentiation over single characters. Keys are given to identify these 5 taxa.
Ambiguity and the abstract tact: A signal detection analysis

Abstract Four observers who had completed a formal course in projective test techniques were asked to discriminate House-Tree-Person (H-T-P) drawings made by psychiatric patients from those made by nonpatients. A 4.5 kHz tone presentation was made contingent upon one of two classes of errors, failure-to-tact errors or false-tact errors, depending on the experimental condition in effect. The observers were instructed that a 2 second tone presentation would occur each time the experimenters disagreed with the observer. The duration of tone presentation was variable depending upon the number of disagreements that occurred after blocks of either 5 or 10 responses. All observers showed some degree of abstractional control by the set of patient drawings. The likelihood of a correct tact was shown to vary as a function of the consequences contingent upon each type of error for 3 of the 4 observers. However, the discriminability index d'e remained unchanged for all observers throughout all experimental conditions.
Optical Coherence Tomography of Cavitary Retinoblastoma

Cavitary retinoblastoma is a unique form of retinoblastoma that demonstratescharacteristic intralesional translucentcavities thatare oftenmorepronounced following tumor regression.1-4Therecanbe a single or multiple cavities, which are usually gray and spherical in configuration.Histopathologically, there isnoendothelial or epithelial lining. The cavities are typically hypofluorescent on fluorescein angiography and echolucent on B-scan ultrasonography.2 In this case, a youngboywith regressed retinoblastoma following intra-arterial chemotherapy demonstrated several large intralesional cavities (Figure, A). Handheld spectral-domain optical coherence tomography revealed distinct, large, hyporeflective cavities temporal to the fovea (Figure, B). The cavities demonstrated smooth surface topography, were located predominantly in the inner retina, spared the retinal pigment epithelium, measured approximately 2 mm in elevation, and caused relative shadowing of outer retinal tissue and thin choroid.
Highly fluorescent cucurbit[8]uril–perylenemonoimide host–guest complexes as efficient fluorescent probes for N-terminal phenylalanine

We report host–guest fluorescent complexes based on cucurbit[8]uril (CB[8]) and water-soluble perylenemonoimide PMI-1. The fluorescence of CB[8] : PMI-1 complexes reverses after the displacement with other guest molecules and they could serve as selective and sensitive probes for N-terminal phenylalanine peptides.
Kinetic-mechanistic studies of P. cepacia lipase catalyzed corona charge selective micelle degradation

Abstract The polyester cores of micelles that self-assemble from poly(caprolactone)-poly(ethylene oxide) block copolymers (HO-PCL-b-PEO-X) are substrates for P. cepacia lipase-catalyzed hydrolytic degradation. The charge on the micelle corona can be modified by varying the PEO end group (X) with neutral ( CH2CH CH2, OMe), positively charged ( NH3+), or negatively charged ( CO2−, SO3−) groups. The latter set of substrates has the added benefit that the corona charge can be changed by varying the pH. P. cepacia lipase has isoforms that manifest highly selective catalytic degradation of micelles depending on the corona charge. One isoform or group of isoforms (L(I)) selectively hydrolyze micelles with neutral or negatively charged coronas, whereas a second isoform or group of isoforms (L(II)) selectively hydrolyze micelles with neutral or positively charged coronas. The L(I) isoform was selectively inhibited, exposing the activity of the L(II) form. The occurrence of P. cepacia isoforms that was initially revealed by kinetic studies has been confirmed by two-dimensional gel electrophoresis with isoelectric focusing. Micelle surface charge could be employed as a strategy in the design of micelles for control of the transport and release of therapeutic substances.
The Digital Divide and Other Economic Considerations for Network Neutrality

In its 2016 Broadband Report, the Federal Communications Commission (FCC) recognizes that a rural/urban digital divide remains prevalent—especially with respect to broadband adoption. It also highlights several policies that the FCC has undertaken purportedly to reduce the divide, including the 2015 Open Internet Order (OIO)—in which the stated intent is to enforce “network neutrality.” However, long before the OIO, studies have raised concerns that network neutrality policies will discourage investment by internet service providers (ISPs) in broadband infrastructure, to the detriment of broadband accessibility, and may increase average consumer costs—both of which would only further exacerbate the digital divide. In this paper, we provide a holistic analysis of the effects of net neutrality on the digital divide; in doing so, we draw from recent economic research on this issue. Our goal is to present a range of economic considerations that should be taken into account when evaluating the overall impact of the OIO, with particular attention to its impact on the digital divide.
A 10-bit 400 MS/s asynchronous SAR ADC using dual-DAC architecture for speed enhancement

This paper presents a high-speed and power-efficient successive-approximation-register (SAR) analog-to-digital converter (ADC). A dual-DAC architecture is proposed to enhance the conversion rate by decreasing the worst-case logic delay and thus the time needed for each conversion cycle. A 1-bit redundancy is introduced to absorb the decision errors caused by the mismatch between the two DACs and to relax the DAC settling requirement. In addition, an addition-only digital error correction technique is utilized to convert the non-binary codes into binary ones. A 10-bit SAR ADC is designed in a 28-nm FDSOI CMOS technology. The ADC achieves a signal-to-noise-plus-distortion ratio (SNDR) of 59.69 dB at the Nyquist input frequency, while consuming 1.53 mW from a 1.0 V power supply at 400 MS/s. The resulting figure-of-merit (FOM) is 4.86 fJ/conv.-step.
Methods for Virtual Screening of GPCR Targets: Approaches and Challenges

Virtual screening (VS) has become an integral part of the drug discovery process and is a valuable tool for finding novel chemical starting points for GPCR targets. Ligand-based VS makes use of biochemical data for known, active compounds and has been applied successfully to many diverse GPCRs. Recent progress in GPCR X-ray crystallography has made it possible to incorporate detailed structural information into the VS process. This chapter outlines the latest VS techniques along with examples that highlight successful applications of these methods. Best practices for increasing the likelihood of VS success, as well as ongoing challenges, are also discussed.
Advances in fetal echocardiography.

Abstract The development of fetal echocardiography and success in prenatal cardiac screening programs over the past 30 years has been driven by technical innovation and influenced by the different approaches of the various specialties practicing it. Screening for congenital heart defects no longer focuses on examining a limited number of pregnant women thought to be at increased risk, but instead forms an integrated part of a high-quality anatomical ultrasound performed in the second trimester using the ‘five-transverse view’ protocol. A prenatal diagnosis is feasible in almost all cardiac lesions and the advantages to parents and to health professionals are well recognized. Prenatal evaluation can usually determine the level of care required at delivery, thereby reducing perinatal morbidity. However, only half of the babies undergoing surgery within the first year of life have a prenatal detection, and practical training programs to support and provide feedback to sonographers remain essential for continued improvement.
If you build it, will they come? Lessons learned in recruiting students for randomized controlled trials in postsecondary settings

Randomized controlled trials (RCTs) are considered the most methodologically sound methods of conducting empirical research, but a successful RCT is contingent on the recruitment of subjects into t...
Does the Poly (ADP-Ribose) Polymerase Inhibitor Veliparib Merit Further Study for Cancer-Associated Weight Loss? Observations and Conclusions from Sixty Prospectively Treated Patients.

Abstract Background: More than 80% of patients with advanced cancer develop weight loss. Because preclinical data suggest poly (ADP-ribose) polymerase (PARP) inhibitors can treat this weight loss, this study was undertaken to explore the PARP inhibitor veliparib for this indication. Objective: The current study was undertaken to analyze prospectively gathered data on weight in cancer patients on PARP inhibitors. Design/Setting: The current study relied on a previously published, prospectively conducted phase 1 single institution trial that combined veliparib and topotecan (NCT01012817) as antineoplastic therapy for advanced cancer patients. Serial weight data and, when available and clinically relevant, computerized tomography scans were also examined. Measurements: The primary endpoint was 10% or greater weight gain from trial enrollment. Results: Nearly all 60 patients lost weight over time. Only one patient manifested a 10% or greater gain in weight. However, review of computerized tomography L3 images...
The Pain of Isolation

Carol, a CFA®, worked at a large Wall Street bank, surrounded by smart, funny, and like-minded people. She started investing in the stock market when she was 14 years old and loves the world of investing. She told me how fortunate she felt to be working with equity investing. It was her favorite subject matter; she reads and talks about the markets even during her free time. Her job was challenging and fulfilling, but she started to be less and less interested in going to work and she became increasingly depressed.
Overview of the Impact of Psychiatric Disorders on Sleep

There is extensive overlap between sleep disturbances and psychiatric illness, especially mood and anxiety disorders. This article provides a general review of subjective and objective sleep characteristics that may be affected by mental disorders, as well as a discussion of how sleep difficulties can influence the course of psychiatric disorders.
A Hybrid Deep Clustering Approach for Robust Cell Type Profiling Using Single-cell RNA-seq Data

Single-cell RNA sequencing (scRNA-seq) is a recent technology that enables fine-grained discovery of cellular subtypes and specific cell states. It routinely uses machine learning methods, such as feature learning, clustering, and classification, to assist in uncovering novel information from scRNA-seq data. However, current methods are not well suited to deal with the substantial amounts of noise that is created by the experiments or the variation that occurs due to differences in the cells of the same type. Here, we develop a new hybrid approach, Deep Unsupervised Single-cell Clustering (DUSC), that integrates feature generation based on a deep learning architecture with a model-based clustering algorithm, to find a compact and informative representation of the single-cell transcriptomic data generating robust clusters. We also include a technique to estimate an efficient number of latent features in the deep learning model. Our method outperforms both classical and state-of-the-art feature learning and clustering methods, approaching the accuracy of supervised learning. The method is freely available to the community and will hopefully facilitate our understanding of the cellular atlas of living organisms as well as provide the means to improve patient diagnostics and treatment.
Assessing Spatial Relationships between Prescription Drugs, Race, and Overdose in New York State from 2013 to 2015

Over the last decade, New York State has experienced one of the greatest increases in opioid overdose deaths in the United States, particularly from heroin and synthetic opioids. This study investigated spatial patterns in the distribution of county-level rates of overdose deaths in New York State and associations between prescriptions for opioid pain relievers, race, and overdose deaths from 2013-2015. Global and local Moran's I tests for spatial autocorrelation examined Bayesian smoothed rates of overdose for clusters of counties with high and low rates of overdose mortality. Getis Ord* analyses identified local hotspots of high and low clusters of overdose. Model performance indicators selected the best-fitting spatial regression model to examine associations between prescriptions for opioid pain relievers, race/ethnicity (non-Hispanic White, Black, and Hispanic) after adjusting for spatial dependence in the data. Socio-demographic characteristics of clusters were examined. Findings suggest rates of opioid overdose deaths are clustered in New York. Rates of prescription opioids were associated with rates of overdose from any opioid, prescription pain relievers, and synthetic opioids. Greater populations of African Americans were associated with greater rates of heroin overdose death rates. Findings from this study inform public health opioid overdose prevention interventions and policies.
A Call to Focus on Racial Domination and Oppression: A Response to “Racial and Ethnic Inequality in Poverty and Affluence, 1959–2015″

In this essay, I respond to Racial and Ethnic Inequality in Poverty and Affluence, 1959–2015 (hereafter Racial and Ethnic Inequality). I argue that Racial and Ethnic Inequality does not fully explain racial inequality in poverty and affluence—particularly among black Americans and American Indians compared to white Americans—because the manuscript follows conventional approaches to the study of racial inequality that obscure racial domination and oppression in the US. These conventional approaches include (1) highlighting the racial gap in a given outcome without conceptualizing and historicizing the social construction of race, (2) theorizing human capital as race-neutral to account for racial inequality, and (3) employing data analyses that reflect analytic bifurcation, which treat racial groups as real essences, monolithic, and position white Americans as the standard against which people of color are measured. These conventional approaches are not unique to Racial and Ethnic Inequality. My goal is to use Racial and Ethnic Inequality as an illustrative example of how conventional approaches address the idea of “race” in sociological research, and whether these approaches provide readers with the most optimal ways to understand racial inequality in the US. I make several recommendations to move research on racial inequality forward. My intention is to spark a conversation about what can be considered “best practices” in addressing the role of race in racial inequality research.
Need of Mathematical Formalism in Proposals for Robust Modeling

If proposals for improving research practices in modeling make claims or recommendations about validity of statistical procedures, then they have to be also complemented by a formal argument so that the statistical credibility of their claims can be established.
Introduction: The Unconventional Feminine

Ever since the sexual revolution when it was determined that woman would no longer passively submit to the rigid and degrading roles inflicted upon her by patriarchy, woman has been searching for new ways to express herself and individuate as a woman. Womanhood has been in the making since then and the exploration of the endless possibilities that are open for a woman to express herself as a woman has been exhilarating. This introduction situates the book in this movement of exploration as well as explores the genre of wisdom literature to which the Song of Songs belongs.
A Built In Test circuit for waveform classification at high frequencies

We introduce a new Build In Test (BIT) signature generator for functional verification and output classification of RF integrated circuits. The proposed circuit is a single rectifier-based MOS transistor, with the substrate and gate independently biased to control source terminal voltage range, followed by a passive RC filter. The proposed technique correlates the Circuit Under Test (CUT) characteristics with the dc voltage provided at the output of the BIT circuit. The output from the proposed circuit is used as signature from which we verify the performance specifications and also characterize the CUT output waveform with respect to amplitude and shape. In normal operation the proposed low cost test scheme ensures the minimum effect at the performance of the measured circuit under test since the only additional load is the source of the MOS transistor attached to it.
A Case of Seronegative ANA Hydralazine-Induced Lupus Presenting With Pericardial Effusion and Pleural Effusion.

Hydralazine induced lupus syndrome (HILS), a form of Drug-Induced Lupus (DIL), was first reported in 1953. Since then, studies have shown an increasing incidence of HILS. It presents with lupus-like symptoms such as arthralgia, fever, chest pain, anorexia, fatigue, petechiae, and rash. Though rare, HILS may initially present with pericardial effusion. Lab findings of HILS usually show positive anti-nuclear antibody (ANA) in >95% of cases, antihistone abs in >95% of cases, rheumatoid factor ab in 20%, and anti-double-strand DNA in <5%. Herein we present a case of HILS which initially presented with a seronegative ANA and pericardial effusion. An 82-year-old woman who presented with shortness of breath was found to have bilateral pleural effusion and pericardial effusion. Common etiologies of pericardial effusion have been ruled out, after careful review of her home medications, hydralazine was suspected to be the culprit of her pericardial effusion. Initial ANA testing was negative, however given high clinical suspicion autoimmune disease screening was done revealing positive anti-histone antibodies. Hydralazine was deemed to be the etiology of her pericardial effusion which led to the discontinuation of the drug. Serial echocardiography revealed no recurrence of the effusion.
A shape optimization method for moving interface problems governed by the heat equation

Abstract The one dimensional Stefan problem is reformulated as a shape optimization problem for the position of the phase transition as a function of time. The functional to be minimized is the mismatch of the Dirichlet to Neumann map at the moving interface. We show that the minimizer is the only stationary point of the shape functional. A gradient based optimization method is derived using shape calculus. The state and adjoint equations of the heat equation are solved with integral equation techniques which avoid a discretization in the domain. A Nystrom quadrature method is analyzed and numerical results are presented.
Is mapping the BCG vaccine‐induced immune responses the key to improving the efficacy against tuberculosis?

In recent years, the century-old Mycobacterium bovis Bacillus Calmette-Guerin (BCG) vaccine against tuberculosis (TB) has been re-evaluated for its capacity to stem the global tide of TB. There is increasing evidence that the efficacy of BCG can be improved by the modified administration methods and schedules. Here, we first discuss recent approaches of vaccine administration, revaccination or boosting that have been used to try to improve the efficacy of BCG against TB. We then dive deeper into studies investigating the immune correlates of protection and describe studies that have investigated BCG-specific T-cell responses and the influence of environmental exposures. These studies all highlight that there is still a lot to learn about the immune response induced by BCG, both in terms of phenotype and specificity, which has been surprisingly understudied. We argue that several critical gaps in knowledge exist and must be addressed by future research to rationally improve the efficacy of BCG, including comprehensive, proteome-wide understanding of the epitopes derived from BCG recognized by BCG-vaccinated individuals, the phenotype of responding antigen-specific T cells and how previous exposure to environmental mycobacteria affect these parameters and thus influence vaccine efficacy. The development of modern techniques allows us to answer some of these questions to better understand how BCG works in terms of both protection against TB and the immune response that it triggers.
Exploring different textures of a nematic liquid crystal for quantitative Fourier phase contrast microscopy

Abstract Quantitative phase microscopy (QPM) has emerged as a viable technique for investigating biological and biomedical samples in its natural environment. Contrary to well established phase microscopes, QPM provides phase map of the optical path length delays introduced by the specimen. Building on our prior technology of the Fourier phase contrast microscopy (FPCM) technique, we present a low-cost and robust quantitative Fourier phase contrast microscopy system that can easily be attached to most commercial brightfield microscopes. This is derived by merging the FPCM technique with phase shifting interferometry. By applying voltages across a nematic liquid crystal cell with various anchoring properties, Stokes’ parameters are obtained to unwrap the object information quantitatively. Further three different nematic textures were considered to improve the utility of the phase unwrapping: planar, twisted, and hybrid. Our results indicate that the hybrid nematic film presents the best phase contrast filter.
Cross-cultural issues in business ethics: A review and research agenda:

This paper reports a systematic literature review of articles published over the past 35 years on cross-cultural issues in business ethics. A screening process resulted in a final sample of 306 pap...
Reply to Patel and Kumar: Epistasis not critical to rate distributions but key in heterotachy, overdispersion, and evolutionary Stokes shift.

In response to Patel and Kumar (1), we consider this letter’s observations to supplement and support what we exposed in our work (2) except for a subtle misunderstanding of our claims. The letter proposes that we explain variability across sites and its particular shape as a gamma distribution solely from epistasis (1). A source of confusion may come from the sentence on (2) > the findings of gamma-distributed fixation rates and heterotachy were not imposed on the model a priori, but they nevertheless emerged as properties of the evolved sequences. However, we do not imply a direct association with epistasis to explain the particular shape of variation but solely when discussing heterotachy, overdispersion, and the evolutionary Stokes … [↵][1]2To whom correspondence may be addressed. Email: faruckm{at}utdallas.edu. [1]: #xref-corresp-1-1
Conservative Treatment of Potentially Curable Minimal, Occult, and Early Breast Cancer: Experience At Memorial Sloan-Kettering Cancer Center, New York

At the Memorial Sloan-Kettering Cancer Center in New York City, we have been careful in adopting this approach to the treatment of early operable breast cancer. It has become obvious from experience in this field that this form of treatment must be guided by careful selection of optimum patient material. Close follow-up must be maintained because of the high incidence of local recurrence and the not infrequent need for salvage surgery. It is also known that these patients must be followed for a long time — a minimum of 10 years, and preferably 15 years.
Opinion Shopping, Audit Firm Dismissals, and Audit Committees

This paper tests whether SEC registrants engage in opinion shopping and examines the role of audit committees when auditors are dismissed (1996-98). There are three main findings. First, companies strategically dismiss incumbent auditors if they are more likely to issue unfavorable audit opinions compared to newly appointed auditors. Using the methodology of Lennox (2000), it is estimated that opinion shopping motivates 17% of auditor dismissals. Opinion shopping dismissals are also found to occur significantly later in the fiscal year compared to other types of dismissals. Second, I use the level and change in meeting activity during the auditor dismissal year to investigate the extent to which committees participate in auditor dismissal decisions. It is estimated that 15% of audit committees do not participate in auditor dismissal decisions but opinion shopping is not significantly associated with participation. Third, Accounting Series Release No. 247 requires that companies disclose whether audit committees approve audit firm changes. After controlling for non-participation, I find audit committees are more likely to disapprove of auditor dismissals that are motivated by opinion shopping. However, independent audit committee members are more likely to leave committees that disapprove of opinion shopping.
Effect of Trajectory Prediction and Stochastic Runway Occupancy Times on Aircraft Delays

This paper examines aircraft delays when arriving flights have been assigned specific times to land by air traffic control. It shows that the benefit from aircraft meeting their prescribed times of arrival with higher precision is moderated if it is not complemented by accurate predictions of runway occupancy times ROTs after touchdown. A single server queueing system is considered, in which the server corresponds to an airport's runway. Landing aircraft are assigned scheduled times of arrival at the runway, which they meet with some stochastic error. The time for an aircraft to clear the runway is included as a random variable in the model. A recursive queueing model is formulated and expressions are derived for the mean and variance of aircraft delays. The analysis then focuses on the effect of unpunctual arrivals on delays and how that is affected by dispersion in aircraft ROTs. A simplified situation, in which model parameters are the same for all aircraft, shows that dispersion in ROTs causes significant losses in throughput efficiency, substantially reducing the benefit of precise trajectory adherence in many cases.
Pulmonary Tuberculosis in a Patient with Cystic Fibrosis.

Context: Mycobacterium tuberculosis (MTB) infection is rarely seen in cystic fibrosis (CF) patients. Case Report: We report a 24-year-old CF patient with fever, cough, hemoptysis, and weight loss of 1week duration prior to admission. Past sputum cultures grew methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. The patient was treated with broad spectrum antibiotics based on previous culture data, but failed to improve. Chest radiograph and computed tomography (CT) chest revealed chronic collapse of the anterior subsegment of right upper lobe and multiple bilateral cavitary lesions which were worse compared to prior films. MTB was suspected and was confirmed by positive acid-fast bacilli (AFB) smears and cultures. After receiving first-line antituberculous drugs, the patient's condition markedly improved. Conclusion: MTB is an infrequent finding, but considered a potential pathogen in CF patients, and may lead to serious pulmonary complications if there is a delay in diagnosis and treatment.
Self-face identification is increased with left hand responses.

Evidence suggests that autobiographical memory, self-related semantic category judgements, and self-identification tasks may be lateralised, with preferential activity in the right anterior temporal and prefrontal cortex. To test this hypothesis, participants (N=10) were presented with morphed images of themselves (self) combined with a famous face. A further set of images was generated in which the face of one of the participant's co-workers (familiar) was combined with a famous face. When compared to morphed images composed of a familiar face, the participants identified images less often as being famous if the images were composed of self, but only when responding with their left hands. This greater “self-effect” found in left-hand responses may imply that when the right hemisphere is preferentially active, participants have a tendency to refer images to self. These data provide further support for a preferential role of the right hemisphere in processing self-related material.
Review Of Coherent Optical Correlation Techniques

A review of coherent optical correlator architectures, techniques and pattern recognition applications is presented.
Measurement and Prediction of Ionic/Nonionic Mixed Micelle Formation and Growth

We investigate synergism in mixed micelle formation and growth in two ionic/nonionic surfactant mixtures. In one mixture, the nonionic surfactant dodecyl hexa(ethylene oxide), or C12E6, is mixed with the ionic surfactant sodium dodecyl sulfate, or SDS. In the other mixture, C12E6 is mixed with sodium dodecyl hexa(ethylene oxide) sulfate, or SDE6S. The SDE6S head, which contains six ethylene oxide units and a sulfate group, “interpolates” between C12E6 and SDS and allows us to investigate in detail the effects of electrostatic and steric interactions between the surfactant heads on mixed micelle formation and growth. For both surfactant mixtures, we measure the critical micelle concentration (cmc) as a function of solution composition, and we use static light scattering to measure the weight-average mixed micelle aggregation number as a function of both solution composition and total surfactant concentration. The analysis of the light scattering data accounts for both micelle growth and intermicellar inter...
Computerized Management Information Systems

Abstract Agricultural production management problems have always been rooted in several disciplines. However, the increasing complexity of the technical knowledge required of a production manager in agriculture today raises serious questions as to whether an individual producer possesses within himself the multiple competencies required to insure the survival of the production unit. The application of modern computer technology is the most promising vehicle through which the agricultural manager can expand his management abilities over the large number of complex disciplines with which he must cope. Computerized management information systems can provide the agricultural manager with accurate, timely information in a form that is most useful for today's management decisions. This paper is an attempt to outline a computerized management information system which could be made available to every manager of a modern dairy operation.
Spectroscopic Study of Tellurium Donors in GaP

The $1s({A}_{1})\ensuremath{\rightarrow}2{p}_{0} \mathrm{and} 2{p}_{\ifmmode\pm\else\textpm\fi{}}$ transitions in Te donors in GaP have been observed. Together with similar data for Si and S donors, Faulkner's effective-mass (EM) calculations yield an ionization energy of 89.8\ifmmode\pm\else\textpm\fi{}0.3 meV for Te donors. Conduction-band effective masses consistent with all the data for these GaP donors are ${m}_{\ensuremath{\perp}}=(0.180\ifmmode\pm\else\textpm\fi{}0.005){m}_{0}$ and ${m}_{\mathrm{II}}=(1.5\ifmmode\pm\else\textpm\fi{}0.2){m}_{0}$. The effects of uniaxial stress on the "two-electron" transitions in the recombination of excitons bound to neutral Te donors in GaP are consistent with the final donor states observed being $s$-like with a valley-orbit splitting.
Near-Total Pharyngeal Reconstruction by 'Rotary-Door' Sternohyoid Myocutaneous Flap in the Dog: A Preliminary Report

• Closure of the pharyngoesophagus after total laryngectomy or partial pharyngectomy is not a difficult problem in most cases. Primary suture repair of the defect is usually adequate, providing sufficient healthy mucosa is available. When this is not feasible, it may be necessary to mobilize tissue from distant sites. The deltopectoral and various myocutaneous flaps are often chosen for this purpose because of their reliability and versatility. Unfortunately, they necessitate either two-stage surgery or involve excessive bulk, and both methods result in unsightly defects, especially in women. The "rotary-door" sternohyoid myocutaneous flap avoids these drawbacks, while utilizing tissues within the surgical field in a singlestage procedure. Seven mongrel dogs underwent total laryngectomy and partial pharyngectomy. The pharyngeal defect was closed with a rotary-door sternohyoid myocutaneous flap. Three dogs had an uneventful recovery and two developed fistulae that closed spontaneously within three weeks of surgery. The pharyngocutaneous repair was found to be intact on postmortem examination. ( Arch Otolaryngol 1985;111:673-676)
Excretion of creatine and creatinine in feces of man.

SummaryTo examine the effects of a high beef diet on the bacterial flora and chemical composition of feces, 10 healthy human adults were fed four diets in succession for 1 month each: a control diet, meatless diet, high beef diet, and a repeat control diet. As a part of the larger study, creatine and creatinine were measured in the food consumed and in the feces excreted. Food creatine concentration was 5- to 12 -fold greater than creatinine; food creatine and creatinine were increased 4- and 10-fold, respectively, in the high beef diet compared with the control diets. Fecal creatine concentration was significantly elevated during the high beef diet (1.3-fold) over that in the control diets, whereas fecal creatinine excretion was elevated with only the meatless diet. Thus, creatinine and creatinine are present in human feces, and dietary creatine has an incomplete absorption during consumption of high beef diets.
Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors

Purpose: The human tumor-derived soluble MHC I-chain–related molecule (sMIC) is highly immune suppressive in cancer patients and correlates with poor prognosis. However, the therapeutic effect of targeting sMIC has not been determined, due to the limitation that mice do not express homologs of human MIC. This study is to evaluate the therapeutic effect of a monoclonal antibody (mAb) targeting sMIC in a clinically relevant transgenic animal model. Experimental Design: We treated the engineered MIC-expressing “humanized” TRAMP/MIC bitransgenic mice at advanced disease stages with a sMIC-neutralizing nonblocking anti-MIC mAb and assessed the therapeutic efficacy and associated mechanisms. Results: A sMIC-neutralizing nonblocking anti-MIC mAb effectively induced regression of primary tumors and eliminated metastasis without inducing systemic toxicity. The therapeutic effect is conferred by revamping endogenous antitumor immune responses, exemplified by restoring natural killer (NK) cell homeostasis and function, enhancing susceptibility of MIC+-tumor cells to NK cell killing, reviving and sustaining antigen-specific CD8 T-cell responses, augmenting CD4 T cells to Th1 responses, priming dendritic cells for antigen presentation, and remodeling tumor microenvironment to be more immune reactive. Conclusions: Therapy with a sMIC-neutralizing nonblocking anti-MIC mAb can effectuate antitumor immune responses against advanced MIC+ tumors. Our study provided strong rationale for translating sMIC-neutralizing therapeutic mAb into clinics, either alone or in combination with current ongoing standard immunotherapies. Clin Cancer Res; 1–12. ©2015 AACR.
Microplate assay of acetylcholinesterase inhibition kinetics in single-mosquito homogenates

Abstract We have investigated the suitability of microplate assay methods for estimating the bimolecular rate constant ki and I50 for inhibition of acetylcholinesterase by selected organophosphates and carbamates in small portions of single-mosquito homogenates. Dilutions of homogenate up to 1:30 were used to measure these kinetic parameters. Absorbance values (or visual estimations) may be used to evaluate directly inhibitor potency in a particular assay. Practical values for these kinetic parameters may be rapidly and simply obtained using single concentrations of substrate and inhibitor. We determined variability of inhibited enzyme activities within a sample population of Anopheles gambiae using measurements from individual insects. The kinetic treatment used in analysis of microplate assay data is discussed together with the potential role of this technique in studies of enzyme inhibition phenomena associated with insecticide resistance.
Perspectives on computer personnel research

Research appearing in Computer Personnel has focused on a number of topics between April 1994 and January 1998, the most consistent topic concerned the careers of information systems professionals. In preparation of articles, researchers have used a variety of references for their work. A surprising number of texts have been cited; the number of text citations is about 30% of the number of journal citations.The time period studied represents the first four years of Computer Personnel being a blind, peer reviewed journal. This article will review citations during this four year period and will make comparisons of the citations to recent journal rankings in Communications of the ACM.
Partial lung bypass reduces pulmonary edema induced by kerosene aspiration in dogs

Kerosene aspiration causes severe pulmonary capillary leak in dogs that is reduced by lowering pulmonary vascular pressures with plasmapheresis. In this study, we tested the possibility that partial lung bypass (PLB) with a veno-arterial extracorporeal circuit previously used for membrane oxygenation (ECMO) would decrease kerosene-induced pulmonary edema. Twelve dogs having a stable pulmonary capillary wedge pressure (Ppw) of 10 tort received 0.25 mL/kg of kerosene into each mainstem bronchus. After 1 hour, the dogs were separated into two equal groups: a control group (C) in which Ppw was maintained at 10 torr until 5 hours after injury, and a PLB group in which PLB reduced Ppw to 5 torr, associated with a 25% reduction in pulmonary blood flow. The blood was pumped back into the distal aorta with blood gas tensions matched by ECMO to the values exiting the lungs as sampled in the left ventricle. In the C group, extravascular thermal volume (ETV) increased from 8.7 ± 4.7 mL/kg to 32.9 ± 26.2 mL/kg between 1 and 5 hours postinjury (P < .05). In the PLB group, ETV increased less between 1 hour (11.7 ± 3.3 mL/kg) and 5 hours (16.5 ± 6.8 mL/kg). Therefore, the values at 5 hours were different between the groups (P < .05). The wet lung weight to body weight ratios of lungs excised at 5 hours were also much less (P < .05) in PLB (20 ± 5 mL/kg) than in group C (40 ± 18 mL/kg). We conclude that PLB reduces edema formation during a pulmonary capillary leak state by reducing pulmonary vascular pressures and/or flows. This supports a therapeutic approach to kerosene pneumonitis that seeks the lowest Ppw compatible with adequate cardiac output and oxygen transport, and suggests an additional benefit of the ECMO circuit in pulmonary vascular leak over and above supporting inadequate lung oxygen exchange at reduced FIO2 and oxygen toxicity.
Modeling the prediction of elementary school adjustment from preschool temperament

Abstract While there is a growing body of research demonstrating associations between temperament and behavior problems, there are few longitudinal studies of temperament rated in early childhood, and behavior problems and skills assessed during the elementary school years in which different sources of data are used. In this research, parental ratings of temperament at age 5 years were used to predict school performance problems, behavior problems and positive social behaviors as rated by teachers at age 8 years. Using Latent Variable Path Analysis With Partial Least Squares Estimation parent rated negative emotionality was found to be a substantial predictor of externalizing behavior problems, and a modest predictor of positive social behaviors (negative direction). Also, self-regulation of motor behavior and attention were found to be predictive of school performance problems, and positive social behavior. This study strengthens the empirical literature on the connection between temperament and behavior problems, particularly problems observed in school setting. It underscores the importance of parent rated negative emotionality as a potent predictor of later occurring behavior problems.
Not Quite “Deja Vu All Over Again”: No Child Left Behind Meets Effective Schools Research

Abstract This article examines the connections between No Child Left Behind (NCLB) and the Effective Schools Research Movement. Using historical methodology, the authors argue that although both were premised on building capacity, over time the reform that became NCLB evolved to focus on accountability. This shift disconnected the reform from its research base, resulting in its failure to bring about equity. To save NCLB, policymakers and scholars should reconnect reform efforts with research and adopt policies that favor inspection.
Clinical plantar pressure measurement in diabetes: rationale and methodology

Abstract This article discusses the methodology and rationale for the application of plantar pressure measurement (PPM) to patients with diabetes mellitus in a clinical setting. PPM is often the only dynamic component of the examination and it provides data on the foot-ground interaction during the specific activity (walking) in which plantar ulceration usually occurs. Elevated plantar pressure has been linked both prospectively and retrospectively with plantar ulceration and it is likely that future studies will show PPM to be predictive of both the site of ulceration and the risk of ulceration. The principles of operation of a number of platforms and in-shoe devices together with methods of analysis and display are disscussed. Biomechanical factors which may lead to elevated pressure are briefly discussed and 8 case studies illustrating different facets of the use of PPM in a clinical setting are presented.
Floquet Theory for Time Scales and Putzer Representations of Matrix Logarithms

Dedicated to Allan Peterson on the occasion of his 60th birthday. A Floquet theory is presented that generalizes known results for differential equations and for difference equations to the setting of dynamic equations on time scales. Since logarithms of matrices play a key role in Floquet theory, considerable effort is expended in producing case-free exact representations of the principal branch of the matrix logarithm. Such representations were first produced by Putzer as representations of matrix exponentials. Some representations depend on knowledge of the eigenvalues while others depend only on the coefficients of the characteristic polynomial. Logarithms of special forms of matrices are also considered. In particular, it is shown that the square of a nonsingular matrix with real entries has a logarithm with real entries.