cssi/SciSciGPT-SciSciNet huggingface dataset:
Clinical variability of genetic isolates of Cohen syndrome

Cohen syndrome (CS) (OMIM#216550) is an uncommon autosomal recessive developmental disorder that has been attributed to mutations in the COH1 gene in at least 200 patients of diverse ethnic background so far. The clinical heterogeneity of CS is evident when comparing patients of different ethnic backgrounds, especially when evaluating specific system phenotypes separately, such as the ophthalmic and central nervous systems. We reviewed the available clinical data on CS cohorts of patients who share a founder effect and demonstrated that most features associated so far with CS are less than those always present in the patients who share a founder mutation thus representing clinical heterogeneity. Furthermore, there is a wide clinical variability of CS in the distinct founder mutation cohorts, the Finnish, Greek/Mediterranean, Amish and Irish travelers. The Greek/Mediterranean founder mutation is correlated to a CS phenotype characterized by specific and persistent skeletal features, corneal changes, periodontal disease, a distinct neurocognitive phenotype for the high recurrence of autism and non-verbal communication and inconstant microcephaly.
An integrated environmental perspective on software as a service adoption in manufacturing and retail firms

In this study, we examine the influence of a firm’s environmental factors on its intention to adopt software as a service (SaaS). We operationalized our assessment of a firm’s environmental pressures as mimetic, coercive and normative pressures and examined the moderating role of perceived technology complexity. Mimetic forces are pressures to copy or emulate other organizations’ activities, systems or structures. Coercive pressures are formal or informal pressures exerted on organizations by other organizations upon which they are dependent. Normative forces describe the effect of professional standards and the influence of professional communities on an organization. We empirically tested our research model using data from 289 valid survey responses. The results provide support for the assertion that there are both significant direct and interaction effects that influence a firm’s SaaS adoption intention. Most important was the significant interaction effects between mimetic pressure and perceived technology complexity. This suggests that the complex relationships proposed by institutional theory and diffusion of innovation help to describe how environmental pressures and perceived technology complexity combine to affect intention to adopt an emerging technology. The theoretical contributions of this study are (i) we integrated, tested and validated mature theories in today’s supply chain era with a new but rapidly diffusing technology, (ii) and we answered the call to include practical technology artifacts in information systems studies. From a practical perspective, through this work managers may develop a better understanding regarding environmental factors and whether or not they should consider these issues for their firm when formulating an intention to adopt SaaS.
Diet-induced alterations in intestinal and extrahepatic lipid metabolism in liver fatty acid binding protein knockout mice

Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol. L-fabp−/− mice were protected against obesity and hepatic steatosis on a high saturated fat (SF), high cholesterol “Western” diet and manifested a similar phenotype when fed with a high SF, low cholesterol diet. There were no significant differences in fecal fat content or food consumption between the genotypes, and fatty acid (FA) oxidation was reduced, rather than increased, in SF-fed L-fabp−/− mice as evidenced by decreased heat production and serum ketones. In contrast to mice fed with a SF diet, L-fabp−/− mice fed with a high PUFA diet were not protected against obesity and hepatic steatosis. These observations together suggest that L-fabp−/− mice exhibit a specific defect in the metabolism of SFA, possibly reflecting altered kinetics of FA utilization. In support of this possibility, microarray analysis of muscle from Western diet-fed mice revealed alterations in genes regulating glucose uptake and FA synthesis. In addition, intestinal cholesterol absorption was decreased in L-fabp−/− mice. On the other hand, and in striking contrast to other reports, female L-fabp−/− mice fed with low fat, high cholesterol diets gained slightly less weight than control mice, with minor reductions in hepatic triglyceride content. Together these data indicate a role for L-FABP in intestinal trafficking of both SFA and cholesterol.
Implementing health information exchange for public health reporting: a comparison of decision and risk management of three regional health information organizations in New York state

Health information exchange (HIE) is a significant component of healthcare transformation strategies at both the state and national levels. HIE is expected to improve care coordination, and advance public health, but implementation is massively complex and involves significant risk. In New York, three regional health information organizations (RHIOs) implemented an HIE use case for public health reporting by demonstrating capability to deliver accurate responses to electronic queries via a set of services called the Universal Public Health Node. We investigated process and outcomes of the implementation with a comparative case study. Qualitative analysis was structured around a decision and risk matrix. Although each RHIO had a unique operational model, two common factors influenced risk management and implementation success: leadership capable of agile decision-making and commitment to a strong organizational vision. While all three RHIOs achieved certification for the public health reporting, only one has elected to deploy a production version.
Catharine MacKinnon May Not Be Enough: Legal Change and Religion in Catholic and Sunni Jurisprudence

This article asserts that legal change in systems influenced by religion requires a legitimizing hermeneutic rooted in sacred texts and tradition. I argue that a number scholars of legal history (Michael Klarman), feminist jurisprudence (Catharine MacKinnon, Katherine Bartlett and Elizabeth Schneider) and narrative theory (Jacques Derrida, Richard Delgado and Jean Stefancic) explicitly or implicitly accept that legal reform is in some sense determined by underlying social shifts attributed variously to public opinion, consciousness or narrative. Although I generally agree with this view, my research comparing the law and theory governing divorce and leadership by women in Roman Catholicism and Sunni Islam indicates that religious communities require the additional step of a hermeneutic to validate legal change. Thus, proposed legal reform in cultures influenced by religious thought (even if only on select issues) ought to address hermeneutics in order to be successful.
Immigration and Globalization: A Review Essay

This essay revisits the argument that the removal of worldwide immigration restrictions would induce a very large increase in world GDP. The recent books Exodus: How Migration is Changing Our World by Paul Collier and The Price of Rights: Regulating International Labor Migration by Martin Ruhs raise a number of questions about the underlying economic model. The essay shows how these concerns can greatly attenuate the predicted gains.
Noncompensatory Partnership Options: The Proposed Regulations

This article analyzes the new proposed regulations addressing noncompensatory options to acquire partnership interests. In addition, the article provides numerical examples to illustrate some of the primary concepts contained in the proposed regulations.
The State of Empirical Research on International Commercial Arbitration: 10 Years Later

This paper, prepared for the 30th anniversary conference of the School of International Arbitration at Queen Mary University of London, highlights some empirical studies on international commercial arbitration that have been published during the past ten years. Part 1 offers some comments on surveys and simulations as a source of quantitative data on international arbitration. Part 2 then highlights some non-survey studies of particular interest. It examines empirical research on (1) the use of arbitration clauses; (2) court enforcement of international arbitration awards; and (3) macroeconomic effects of international commercial arbitration.
Risk factors predicting revision surgery after medial epicondylectomy for primary cubital tunnel syndrome

Background Medial epicondylectomy (ME) is one of several accepted surgical options for the treatment of cubital tunnel syndrome (CuTS). Although reported outcomes after ME are generally favorable, few data exist regarding which patients are prone to poorer outcomes requiring revision surgery. The goal of this study was to identify risk factors predicting the need for revision surgery after ME for the treatment of CuTS. Methods We conducted a retrospective chart review of all patients treated at our institution with ME for CuTS from 2006 through 2011. We identified patients who underwent additional operations for recurrent or persistent ulnar nerve symptoms as the revision cohort. We performed bivariate analysis to determine which variables had a significant influence on the need for revision surgery. We examined qualitative factors associated with revision, including the degree of bony resection performed during the index ME, and intraoperative findings at the time of revision surgery. Results Revision surgery was required in 13.3% of cases (11 of 83). On bivariate analysis, younger age, associated workers' compensation claims, lesser disease severity, and preoperative opioid use were all significant predictors of the need for revision surgery. Perineural scarring and heterotopic bone formation about the elbow were the 2 most common findings at the time of revision. Conclusions For patients with CuTS, the risk of revision surgery after ME is higher in younger patients, patients with less severe disease, patients taking opioid medications preoperatively, and patients with associated workers' compensation claims. Level of evidence Level IV; Case Series; Treatment Study
Variability of apatite fission-track annealing kinetics: III. Extrapolation to geological time scales

A new model for examining fission-track data from natural specimens has been developed on the basis of new laboratory data describing fission-track annealing in a wide variety of apatites and the empirical correction for fission-track length anisotropy presented in earlier papers. Using revised and simplified statistical methods, we examine how well various empirical equations are able to fit the laboratory data and reproduce expected behavior on geological time scales. Based on the latter criterion, we find that so-called "fanning Arrhenius" models of mean track length are not the best-suited for our data. Instead, we find that fitting c-axis projected lengths with a model that incorporates some curvature on an Arrhenius plot produces results that are in better agreement with the available geological benchmarks. In examining the relative annealing behavior of apatites with different resistance to annealing, we find that the laboratory-time-scale behavior of any two apatites can be reproduced well by a simple one- or two-parameter equation. This function is used to convert the reduced fission-track length of one apatite that has undergone a certain time-temperature history into the length that would be measured in a second, less-resistant apatite that has undergone the same history. Using this conversion, we create a single model that encompasses the annealing behavior of all of the apatites we studied. The predictions made by this model match closely those made by fits to data for individual apatites. We therefore infer that, although the conversion equation is imperfect, it presents an excellent practical solution to characterizing the range of kinetic variability for annealing of fission tracks in apatite.
Unilateral luteotropic effect of uterine venous effluent of a gravid uterine horn in sheep.

The involvement of the main uterine vein in the unilateral maintenance of CL was studied in bilaterally ovulating unilaterally pregnant ewes. Ewes were mated at estrus (Day 0) and bilaterally ovulating ewes were randomized into three groups at surgery on Day 5. In all ewes, the uterine horns were separated through the intercornual area and one was ligated and transected near the internal bifurcation to produce a nongravid horn. One group served as controls (five ewes). In the other two groups the main uterine vein on one side was surgically anastomosed (end to side) to the corresponding vein of the opposite side (gravid side to nongravid side in one group--three ewes, and nongravid side to gravid side in the other--three ewes). Necropsies were done on Day 20. Mean CL weight was less, (P less than .01) on the nongravid side in control ewes than on the gravid side in control ewes or for either side in the other two groups. There were no significant differences among mean weights of CL on the gravid side in control ewes and either side in the other two groups. The CL regressed when the ipsilateral uterine vein contained blood from only the nongravid horn whereas the CL was maintained when the ipsilateral uterine vein contained venous blood from a gravid horn, whether or not it also contained blood from a nongravid horn. Results indicate that the uterine venous effluent from a gravid uterine horn in sheep has a luteotropic effect on the ipsilateral CL.
Angle Inequality for Judging the Transition from Cassie–Baxter to Wenzel States When a Water Drop Contacts Bottoms of Grooves between Micropillars

A specific criterion is often used to judge the transition from Cassie–Baxter wetting state to that of Wenzel. In this work, we examine the applicability of this specific criterion to the case of micropillars with circular or polygonal cross-sections. For this purpose, we derive an angle inequality. When this angle inequality is violated, the specific criterion holds for the corresponding micropillars. Otherwise, the specific criterion may not be applicable to such micropillars. These results are validated by pressing tests on six types of micropillars, which have circular, triangular, square, hexagonal, T-shaped, and star-like cross-sections.
Is it still "Big Data" if it fits in my pocket?

"Big Data" is a hot topic but, in many ways, we are still trying to define what the phrase "Big Data" means. For many, there are more questions than answers at this point. Is it about size alone? Complexity? Variability? Data shape? Price/performance? New workloads? New types of users? Are existing data models, data management systems, data languages, and BI/ETL tools relevant in this space? Is MapReduce really a "major step backwards"? I have spent time over the last several years trying to answer many of these questions to my own satisfaction. As part of the journey I have witnessed a number of natural patterns that emerge in big data processing. In this talk I will present a catalog of these patterns and illustrate them across a scale spectrum from megabytes to 100s of petabytes. Finally, I will offer some thoughts around a systems and research agenda for this new world.
Psychological Screening of Impotent Men

AbstractRapid advances in methods of treating sexual impotence have produced concomitant demands for more specific diagnosis and determination of prognosis. Herein are presented guide lines for a rapid screening procedure that has diagnostic and prognostic utility. Use of 2 decisional rules for the Minnesota Multiphasic Personality Inventory, an easily administered and scored psychological test, can provide assistance to the urologic surgeon in determining the suitability of a candidate for a corrective operation. Case histories illustrate the value of this test in making treatment recommendations and assessing prognosis.
PURIFICATION AND PARTIAL CHARACTERIZATION OF SPHINGOMYELIN FROM HUMAN PLASMA.

Isolation of pure sphingomyelin from human plasma on a preparative scale is described. Analyses of fatty acids by gas-liquid chromatography on two polar polyester columns indicate the presence of all even- and odd-carbon, saturated fatty acids from C14 to C25 and most of the corresponding monoenoic acids as well. Palmitic acid is the predominant component; seven of the acids constitute over 90% of the total fraction. A previously unassigned trace constituent of the fatty acid fraction has been tentatively identified as a C24 dienoic acid on the basis of relative retention times, microhydrogenation, and reaction with mercuric acetate.
Managing Delayed Puberty

When delayed puberty is simply a normal variation in overall maturation, as it usually is, time alone will often solve the problem. Key factors in assessment are bone age and growth rate. Typical cases are summarized to illustrate the management of common problems. Hormonal treatment for simple delayed puberty is seldom necessary before 14 years of age in boys or 13 years in girls.
Pauci-immune crescentic glomerulonephritis associated with use of trimethoprim–sulfamethoxazole

Drug-induced pauci-immune crescentic glomerulonephritis has been described with several agents, including propylthiouracil, minocycline, d-penicillamine, and hydralazine. We present the case of a 60-year-old man who presented with rapidly progressive glomerulonephritis in the setting of recent use of trimethoprim–sulfamethoxazole complicated by the development of the Stevens–Johnson syndrome, and was found to have biopsy-proven pauci-immune crescentic glomerulonephritis and undetectable anti-neutrophilic cytoplasmic antibodies. We review the existing literature on the potential association between sulfonamides and hypersensitivity polyangiitis.
Consumer Acceptability and Composition of Crayfish Harvested from Commercial Production Fields and Moist-Soil Wetlands

ABSTRACTThe consumer acceptability and proximate and fatty acid composition of crayfish (Procambarus clarkii) harvested from commercial systems and moist-soil wetlands were evaluated. Aroma and appearance acceptability scores for abdominal muscles from commercial crayfish were higher over samples from moist-soil wetlands. Aroma and texture acceptability scores for whole crayfish from commercial fields were also higher compared to moist-soil wetland samples. No differences existed between treatments for flavor and overall acceptability. Results indicate that although scores for aroma were slightly higher for commercial crayfish, crayfish from both populations were acceptable to consumers. Hierarchical cluster analyses of panelists’ scores for overall acceptability revealed that 25% of panelists rated moist-soil wetland and commercial crayfish abdominal samples equally high, and an additional 31% of panelists rated moist-soil wetland crayfish samples as more liked than commercial crayfish samples. Few diffe...
Treatment of Oral Ulcers

Oral ulcers may be the result of allergic, infectious, metabolic, nutritional, or malignant systemic disorders or a variety of other inflammatory diseases. These range from minor irritations to signs of life-threatening illnesses. Patients with oral ulcers should adhere to a variety of general measures that are recommended plus specific treatments for specific diagnoses.
Phonon Spectroscopy Down to 0.3°K

At the present time, it is impossible to investigate lattice vibrations in the frequency range above 1010 cps using ultrasonic techniques. This range is, however, accessible in the thermal conductivity experiment. One can further look upon the thermal conductivity as broad-band spectroscopy in which the source spectrum is swept in frequency by varying the temperature at which the conductivity is measured.
Early Essays on Economic Theory c. 1867–74

It appears that between 1869 and 1873, Marshall committed to paper his first systematic account of the views he was forming about the central questions of economic theory. The manuscripts reproduced here belong to that phase. Their exact purpose remains uncertain: they do not seem to have been written for immediate publication, but are more formal than lecture notes. Most probably they were working drafts, designed to serve eventually as the basis for a more comprehensive and elaborate essay or treatise. But doubtless they were also read by favoured students like Foxwell, Cunynghame or J. N. Keynes,1 and so helped to forward the early propagation of Marshall’s views and claims to originality.2
Steel and Automobiles: The Heavy Industrial Complex

No businessman in his or her right mind would favor a free market. For businessmen, the Darwinian “war of all against all” world of the genuinely free market can be “nasty, brutish, and short.” The struggle to survive is incessant; business life expectancies are fleeting. The average small business in the United States has merely a one in ten chance of struggling beyond its fifth year.
Information Theory to Assess Relations Between Energy and Structure of the U.S. Economy Over Time

This paper describes the changing structure of the United States’ (U.S.) domestic economy by applying information theory-based metrics to the U.S. input–output (I–O) tables from 1947 to 2012. Here the I–O tables are an economic network where the sectors are the nodes. The value of these metrics is that they describe the balance or trade-off between efficiency and redundancy of network flows as well as equality and hierarchy of flows through nodes in a network. I relate these metrics to the U.S. gross power consumption and annual intermediate spending by the food and energy sectors, the latter being a proxy for the inverse of the net power ratio (or net energy) of the economy, to test hypotheses of energy–economy structural linkages. The results of this paper show that increasing gross power consumption, as well as a decreasing share of intermediate expenditures of the food and energy sectors, correlates with increased distribution of money among economic sectors, and vice versa. The information theory metrics indicate two time periods at which major structural shifts occurred. The first was between 1967 and 1972, and the second was around the turn of the twenty-first century when food and energy expenditures no longer continued to decrease after 2002. In response to the latter, it is clear that the U.S. economy did trade off structural reserves (e.g., decreasing metrics of conditional entropy, redundancy, and equality) for structural efficiency (e.g., increasing metrics of efficiency, mutual constraint, and hierarchy) after food and energy expenditures increased post-2002. I also test the structural trends with increasingly simpler (e.g., fewer sectors) representations of the I–O tables, and the results are more consistent for I–O representations that account for inputs and outputs (e.g., value added and gross domestic product) rather than only the intermediate transactions among sectors. The findings of this paper have important implications for economic modeling in at least two ways. First, the paper helps explain how fundamental shifts in resources costs relate to economic structure and economic growth. Second, the paper shows that the number of sectors used to represent economic transactions influences the systemic metrics themselves.
The Pícaro Transfigured: Gavroche in Hugo's Misérables

Hugo's characterization of Gavroche transforms and transcends traditional picaresque depictions of youthful, socially marginal antiheroes. Like them, Gavroche is an abandoned child who must learn t...
Abstract C69: Predicting colonoscopy screening behavior and future intentions in a diverse sample of African Americans in New York State

Objectives: Colorectal cancer is a leading cause of death in the United States; African Americans experience a disproportionate colorectal cancer burden in both its incidence and mortality. Colonoscopy is one of several screening tests recommended to detect disease early, but screening rates are lower among African Americans than non-Hispanic whites. Given the need to address disparities, it is important to understand factors that increase and decrease the likelihood of colonoscopy completion for African Americans. This cross-sectional study examines cognitive and affective decision-making factors as predictors of colonoscopy uptake in a sample of African American New York State residents, ages 50 and older. Methods: Participants were 1687 African American adults aged 50 and older living in the New York City and Buffalo, New York metropolitan areas attending a group educational program. Participants completed surveys assessing positive and negative affective associations with colonoscopy, perceived benefits and barriers, self-efficacy, colorectal cancer knowledge, fear of colonoscopy, perceived risk, cancer worry, and cancer fear. They also reported past screening behavior and future screening intentions. Linear and logistic regressions were used to model decision-making constructs as predictors of past screening behavior and future screening intentions. Results: All of the assessed decision making constructs except for perceived risk were associated with past screening behavior. Perceived benefits (OR=1.25, p Conclusions: Cognitive and affective factors predicted both past colonoscopy screening behavior and future screening intentions. These findings suggest that both cognitive and affective factors impact colonoscopy screening decision-making among age eligible African Americans in New York State. Most interventions only target cognitive components. Thus, future interventions aimed at reducing screening disparities may need to address both cognitive beliefs as well as screening attitudes. Citation Format: Lynne B. Klasko, Lina M. Jandorf, Deborah O. Erwin, Marc T. Kiviniemi. Predicting colonoscopy screening behavior and future intentions in a diverse sample of African Americans in New York State. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr C69.
The Null Effect of Bladder Neck Size on Incontinence Outcomes after Radical Prostatectomy

Purpose: We sought to determine whether bladder neck size is associated with incontinence scores after robot-assisted laparoscopic radical prostatectomy.Materials and Methods: Consecutive eligible patients undergoing robot-assisted laparoscopic radical prostatectomy between July 19 and December 28, 2016 were enrolled in a prospective, longitudinal, observational cohort study. The primary outcome was patient reported urinary incontinence on the EPIC (Expanded Prostate Cancer Index Composite) scale 6 and 12 weeks postoperatively. The relationship between the EPIC score of urinary incontinence and bladder neck size was evaluated by multiple regression. Predicted EPIC scores for incontinence were displayed graphically after using restricted cubic splines to model bladder neck size.Results: A total of 107 patients were enrolled. The response rate was 98% and 87% at 6 and 12 weeks, respectively. Bladder neck size was not significantly associated with incontinence scores at 6 and 12 weeks. Comparing the 90th per...
Bivalent Epigenetic Control of Oncofetal Gene Expression in Cancer

Multiple mechanisms of epigenetic control that include DNA methylation, histone modification, noncoding RNAs, and mitotic gene bookmarking play pivotal roles in stringent gene regulation during lineage commitment and maintenance. Experimental evidence indicates that bivalent chromatin domains, i.e., genome regions that are marked by both H3K4me3 (activating) and H3K27me3 (repressive) histone modifications, are a key property of pluripotent stem cells. Bivalency of developmental genes during the G1 phase of the pluripotent stem cell cycle contributes to cell fate decisions. Recently, some cancer types have been shown to exhibit partial recapitulation of bivalent chromatin modifications that are lost along with pluripotency, suggesting a mechanism by which cancer cells reacquire properties that are characteristic of undifferentiated, multipotent cells. This bivalent epigenetic control of oncofetal gene expression in cancer cells may offer novel insights into the onset and progression of cancer and may provide specific and selective options for diagnosis as well as for therapeutic intervention.
Modeling the Effect of Subtask Boundaries on Driver Glance Behavior

Studies of multitasking while driving have shown that drivers tend to switch attention at subtask boundaries. It is also known that the uncertainty of roadway information plays a significant role in attention switching. Yet, these two approaches have not been modeled together. In this study, we create an attention switching model that accounts for both subtask boundaries and uncertainty, and use Approximate Bayesian Computation-Markov Chain Monte Carlo (ABCMCMC) to determine the weight between the two factors, based on the empirical data. The weight was calculated for each of two different types of tasks, text reading and entry, that have subtask boundaries with different characteristics. We found that the subtask boundary in the text reading task nudged drivers to discontinue the distracting task and switch attention back to the road more than the subtask boundary in the text entry task. This study suggests that task structure may play a role in generating long glances.
Endotoxin-based molecular strategies for the prevention and treatment of gram-negative sepsis and septic shock

As documented in the other chapters of this volume, there is a rapidly growing appreciation that gram-negative sepsis is both an infectious and a systemic inflammatory disease. Extraordinary progress has been achieved in describing at least some of the molecular mechanisms which produce sepsis, especially as they relate to the causative role of bacterial lipopolysaccharides (LPS) or en-dotoxin.
The Impact of Telepresence on Cultural Transmission through Bishoujo Games

Japanese bishoujo videogames take on the characteristics of highly detailed “choose your own adventure” novels. The current case study seeks to present a series of “classic” bishoujo videogames and explain how they function to orient the Western player to the culture of modern Japan through the phenomenon of telepresence. Aspects of telepresence that include transportation and immersion are considered toward the end of offering the player a degree of access to some aspects of modern Japanese culture. It is suggested that, by experiencing a sense of telepresence through inhabiting a Japanese avatar, the nonJapanese player has the potential to obtain a heightened level of competence in negotiating Japanese culture.
Ab Initio Anharmonic Vibrational Analyses of Non-Rigid Molecules

A collection of recent state-of-the-art ab initio results is presefted pertaining to anharmonic vibrational analyses of non-rigid molecules. To demonstrate the performance of electronic structure theory in predicting features of potential energy surfaces to quantitative accuracy, investigations of energy barriers for large-amplitude vibrations in ammonia, isocyanic acid, ethane, and cyclopentene are reported. Anharmonic vibrational analyses based on self-consistent-field and configuration interaction quartic force fields are critically evaluated by focusing on representative results for hydrogen sulfide and nitrous oxide. The use of nonstationary reference structures to improve predictions of anharmonic force fields is reviewed and documented. A summary of an investigation using the complete state-of-the-art armamentarium to elucidate vibrational anharmonicity, vibration-rotation interaction, and the precise r e structure of the quasilinear HNCO molecule is given. Finally, difficulties arising in the application of nonstationary reference geometries in vibrational analyses of large-amplitude motions are highlighted to avert potential pitfalls in future ab initio studies.
"I Was There With Her": Experiences of Mothers of Women With Breast Cancer.

The purpose of this qualitative study was to examine the experiences of mothers of breast cancer patients. The theory of health-related family quality of life informed data collection and data anal...
Predicting the effect of aging and defect size on the stress profiles of skin from advancement, rotation and transposition flap surgeries

Abstract Predicting mechanical stress contours on skin resulting from local tissue rearrangement surgeries is needed to design optimal treatment plans and avoid wound healing complications. Finite element (FE) simulations of skin tissues have been shown to be a reliable tool in preoperative planning, yet, a major obstacle in the creation of predictive software comes from the inherent uncertainty in material properties of biological materials, and the high computational cost of creating and calibrating virtual surgery models. In this study we build computationally inexpensive surrogates to easily predict stress profiles for arbitrary material parameters and a range of defect sizes in three reconstructive scenarios: advancement, transposition, and rotation flaps. The surrogates are built by first creating a training data set of FE simulations that cover the input space of experimentally-determined skin properties from the literature. A reduced order representation of the training data set is achieved via principal component analysis, and computationally efficient surrogates are then created through Gaussian Process (GP) regression. We show that the GP surrogates predict stress contours with relative errors that are on average 2% in the l2-norm compared to the high-fidelity FE models. We apply the GP surrogates to predict differences in the probability densities of stress contours between two different age groups undergoing the same procedure. By replacing nonlinear FE models with accurate yet inexpensive models that can be evaluated for any combination of human skin material parameters and a range of defect sizes, we aim to enable calibration and prediction of stress contours in individualized clinical cases in the near future.
Landscape as Infrastructure: A Base Primer

As ecology becomes the new engineering, the projection of landscape as infrastructure—the contemporary alignment of the disciplines of landscape architecture, civil engineering, and urban planning— has become pressing. Predominant challenges facing urban regions and territories today—including shifting climates, material flows, and population mobilities, are addressed and strategized here. Responding to the under-performance of master planning and over-exertion of technological systems at the end of twentieth century, this book argues for the strategic design of "infrastructural ecologies," describing a synthetic landscape of living, biophysical systems that operate as urban infrastructures to shape and direct the future of urban economies and cultures into the 21st century. Pierre Belanger is Associate Professor of Landscape Architecture and Co-Director of the Master in Design Studies Program at Harvard University’s Graduate School of Design. As part of the Department of Landscape Architecture and the Advansed Studies Program, Belanger teaches and coordinates graduate courses on the convergence of ecology, infrastructure and urbanism in the interrelated fields of design, planning and engineering. Dr. Belanger is author of the 35th edition of the Pamphlet Architecture Series from Princeton Architectural Press, GOING LIVE: from States to Systems (pa35.net), co-editor with Jennifer Sigler of the 39th issue of Harvard Design Magazine, Wet Matter, and co-author of the forthcoming volume ECOLOGIES OF POWER: Mapping Military Geographies & Logistical Landscapes of the U.S. Department of Defense. As a landscape architect and urbanist, he is the recipient of the 2008 Canada Prix de Rome in Architecture and the Curator for the Canada Pavilion ad Canadian Exhibition, "EXTRACTION," at the 2016 Venice Architecture Biennale (extraction.ca).
Pre-harvest Approaches to Improve Poultry Meat Safety

Salmonella and Campylobacter have been responsible for numerous foodborne outbreaks and are often associated with the consumption of poultry meat and meat products. Given the significant public health impact associated with these zoonotic pathogens, it is critical to implement programs aimed at reducing pathogen prevalence along the poultry production continuum. Pre-harvest food safety in broiler production utilizes a methodical approach to control enteric pathogens in breeder flocks, hatchlings, chicks, and market-age birds. This chapter discusses the different intervention strategies that can be applied at the primary production environment to control the introduction, propagation, and dissemination of Salmonella and Campylobacter in broiler chicken production.
The Role Of Social Risk Factors In Dialysis Facility Ratings And Penalties Under A Medicare Quality Incentive Program.

Medicare’s End-Stage Renal Disease Quality Incentive Program is a mandatory pay-for-performance program for US dialysis facilities, in which facilities are penalized up to 2 percent of their total ...
The Role of Metal Ions in Bacteriorhodopsin Function

The literature on the simultaneous dissociation of an acid of pKa ~8.6–10 and the protonated Schiff base and a possible coupling mechanism is reviewed. The effect of metal cations on the color of retinal and the photocycle is also summarized in light of this coupling. Studies using Eu3+ to probe the ion binding sites in bacteriorhodopsin by following the spectroscopy and kinetics of its emission are reported. It is shown that the Eu3+ binding constants for the different sites appear quite similar, and that the total intensity of the emission increases linearly with the amount of added Eu3+. A model is presented incorporating these results, explaining how the retinal color and extent of deprotonation in the photocycle can change sigmoidally with the amount of added cations, based on a requirement that more than one metal ion must be bound to allow these processes to occur.
Perioperative outcomes after tracheoplasty: A NSQIP analysis 2014-2016.

OBJECTIVES Tracheoplasty or tracheal resection and are essential components of the care of patients with severe tracheal stenosis. We aimed to study the perioperative outcomes of patients after tracheoplasty or resection using a national surgical registry. METHODS We analyzed the 2014 to 2016 American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) participant use file for patients who underwent tracheal resection or tracheoplasty (CPT codes 31750, 31760, 31780, and 31781). We analyzed the perioperative outcomes including length of stay (LOS), dehiscence, unplanned reintubations, unplanned surgeries, and 30-day readmission rates. A random 4:1 sample of non-tracheoplasty patients served as the control group. RESULTS From 2014 to 2016, 126 patients underwent tracheoplasty. The median age was 56 years (IQR = 45-63). There were 93 (74%) females, 88 (70%) white, and 3.2% (4/126) Hispanic. The median LOS was 7 days (IQR = 5-10 days). Of these, 4.8% (6/126) developed wound infections and 3/126 (2.4%) developed wound dehiscence. Five out of 126 required unplanned reintubation (4.0%) and 16/126 (13%) had an unplanned reoperation. The 30-day unplanned readmission rate was 16% (20/126). The wound infection, unplanned intubations, and readmission rates were significantly higher (P < .005) than the control group. CONCLUSIONS The 30-day perioperative outcomes of adult patients undergoing tracheoplasty showed that adverse events are common, but severe adverse events such as death are rare. Continued research into risk mitigation among these patients is warranted. LEVEL OF EVIDENCE NA Laryngoscope, 130:1514-1519, 2020.
Diagnostic Biopsies in the Management of Uveitis

Surgery is required in the care of many patients with posterior uveitis: both diagnostically, when noninvasive studies have failed to guide appropriate treatment, and therapeutically, in eyes that have developed sight-threatening structural complications of intraocular inflammation. Recent advances in microsurgical instrumentation, conventional and molecular diagnostic laboratory techniques, multimodal imaging, and novel drug delivery systems have expanded both the diagnostic and therapeutic scope of vitreoretinal surgery in patients with posterior uveitis.
Tuning magnetic anisotropy in Co–BaZrO3 vertically aligned nanocomposites for memory device integration

Ferromagnetic nanostructures with strong anisotropic properties are highly desired for their potential integration into spintronic devices. Several anisotropic candidates, such as CoFeB and Fe–Pt, have been previously proposed, but many of them have limitations such as patterning issues or thickness restrictions. In this work, Co–BaZrO3 (Co–BZO) vertically aligned nanocomposite (VAN) films with tunable magnetic anisotropy and coercive field strength have been demonstrated to address this need. Such tunable magnetic properties are achieved through tuning the thickness of the Co–BZO VAN structures and the aspect ratio of the Co nanostructures, which can be easily integrated into spintronic devices. As a demonstration, we have integrated the Co–BZO VAN nanostructure into tunnel junction devices, which demonstrated resistive switching alluding to Co–BZO's immense potential for future spintronic devices.
Tratamento de dejetos suínos com biorreator UASB

Esse trabalho tem por objetivo analisar a importância do biodigestor UASB no tratamento de dejetos suinos. A suinocultura possui papel importante quanto ao desenvolvimento economico do Brasil. No entanto, o aumento de producao vem causando problemas ambientais graves, por conta do grande volume de residuos solidos gerados pela atividade. O desenvolvimento de metodos de tratamento de dejetos que agreguem valor a producao e respeitem as leis ambientais e um dos grandes desafios do setor. A biodigestao anaerobia e um dos metodos mais eficazes para o tratamento de dejetos de suinoculturas. Este metodo de digestao, denominado UASB, tem como caracteristica principal a producao de biogas e de biofertilizante, produto rico em nutrientes, e livre de patogenos. O metodo oferece vantagens como a promocao do bem estar animal, o aumento da fertilidade do solo, a diminuicao da poluicao e da emissao de gases geradores do efeito estufa e a melhoria da qualidade de vida, nos centros produtores de suinos, alem de minimizar problemas relacionados ao deficit de energia eletrica. Portanto, a utilizacao de biodigestores UASB para o tratamento de dejetos de suinos e uma opcao interessante, que deve ser avaliada com seriedade.
In vitro binding affinity vs. in vivo site occupancy: A PET study of four diastereomers of dihydrotetrabenazine (DTBZ) in monkey brain.

Abstract Introduction In vivo imaging methods such as Positron Emission Tomography (PET) can be used to examine the relationship between in vitro binding affinity and in vivo occupancy of binding sites in the brain for new drug candidates. In this study, PET imaging in monkey brain was used to evaluate that correlation for a set of four diastereomers of the compound dihydrotetrabenazine (DTBZ), the pharmacologically active metabolite of the drug tetrabenazine. Methods PET studies of DTBZ diastereomers were completed in a single monkey brain. In vivo occupancies (ED50) were estimated using multiple drug doses and the vesicular monoamine transporter 2 specific radioligand (+)-α-[11C] DTBZ, employing a test-retest sequence of control PET scan, drug administration and a second PET scan completed on a single day. Results DTBZ has three chiral carbon centers and eight possible stereoisomers, and in vivo occupancy of the target site VMAT2 was observed only for the four diastereomers of DTBZ having the 11bR absolute configuration. The estimated in vivo occupancies (ED50 values from 0.023 to >3.15 mg/kg) correlated well (R2 = 0.95) with the in vitro binding affinities (Ki values of 4 to 600 nM for the VMAT2), and an even better correlation (R2 = 0.99) was found for the three isomers with in vitro binding affinities Conclusions If the physiochemical (MW, log P, pKa) or physiological (metabolism, transport, protein binding) properties of a set of drug stereoisomers are considered similar, the binding affinities determined from in vitro assays may predict the in vivo occupancies of the target binding site in the monkey brain.
Meal Planning for Adults with Diabetes

Nutrition, physical activity, and medication are the three main components of a diabetes management plan. According to the Americans Diabetes Association, there is no one diabetes meal plan; rather, it is a healthful eating pattern specifically designed to meet your individual needs. This new 2-page publication of the UF/IFAS Food Science and Human Nutrition Department provides some basic tips for creating a personalized meal plan for adults with diabetes. Written by Nancy J. Gal and Wendy J. Dahl. https://edis.ifas.ufl.edu/fs323
Review of the Endocannabinoid System

The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in the developing central nervous system as well as playing a major role in tuning many cognitive and physiological processes. The ECS is composed of endogenous cannabinoids, cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of endocannabinoids. In addition to its endogenous roles, cannabinoid receptors are the primary target of Δ9-tetrahydrocannabinol, the intoxicating component of cannabis. In this review, we summarize our current understanding of the ECS. We start with a description of ECS components and their role in synaptic plasticity and neurodevelopment, and then discuss how phytocannabinoids and other exogenous compounds may perturb the ECS, emphasizing examples relevant to psychosis.
Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment

MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.
Incidentally identified variants in TTN-encoded titan found in children undergoing whole exome sequencing and association with Cardiomyopathy

Purpose: We sought to determine whether incidentally identified TTN-encoded titin variants were associated with development of pediatric cardiomyopathy. Background: TTN-encoded titan is the largest protein in the human body and is involved in structural and mechanical development in skeletal and cardiac muscle. Mutations in this gene have been linked to cardiomyopathy (CM), particularly truncating mutations (TTNtv). Conversely, recent evidence has …
QUADRICEPS TENDON AUTOGRAFT HAS LOWER MRI SIGNAL THAN HAMSTRING TENDON AUTOGRAFT IN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTIONS IN ADOLESCENT ATHLETES

Objectives:Hamstring tendon autograft (HTA) is a common graft choice for anterior cruciate ligament (ACL) reconstructions in skeletally immature patients. However, quadriceps tendon autografts (QTA...