cssi/SciSciGPT-SciSciNet huggingface dataset:
The potential for international and transnational public service advertising in public spaces in American and Chinese global cities: Conclusions from a 2010 survey of advertisements in subways in Beijing, New York, Shanghai and Washington, DC

Abstract Can we construct transnational or international public service advertising to counterbalance the proliferation of transnational commercial advertising? As an important first step in exploring the possibility of such an application of shared media public diplomacy among nations, this paper describes a complete survey of commercial and public service advertisements collected from the public spaces of subway systems in American and Chinese cities in 2010 – New York, Washington, DC, Shanghai and Beijing – to reveal the range of themes of commercial and public service ads in these spaces. The study reveals first that analogous commercial and public service ads are ubiquitous in the public spaces of both Chinese and American cities. Second, many of the themes that might appear in international or transnational public service ads are already being portrayed in ads created by local or national governments or NGOs, although these themes are portrayed in ads created by different sets of actors in China and in the US: government actors and a few international NGOs in Chinese cities, and governments, corporations and non-profit organizations in the case of American cities. Finally, the survey reveals that in all four cities there are many commercial advertisements that appeal to the identity of a transnational consumer, but that there are almost no public service ads that appeal to the identity of a transnational citizen: merely local or national ones who can solve such public problems as global warming, education, and health issues.
Deposition and germination of conidia of the entomopathogen Entomophaga maimaiga infecting larvae of gypsy moth, Lymantria dispar.

Abstract Germination of conidia of Entomophaga maimaiga , an important fungal pathogen of gypsy moth, Lymantria dispar , was investigated on water agar and larval cuticle at varying densities. Percent germination was positively associated with conidial density on water agar but not on larval cuticle. When conidia were showered onto water agar, the rate of germination was much slower than on the cuticle of L. dispar larvae. From the same conidial showers, the resulting conidial densities on water agar were much higher than those on larval cuticle in part because many conidia adhered to setae and did not reach the cuticle. A second factor influencing conidial densities on larval cuticle was the location conidia occurred on larvae. Few conidia were found on the flexible intersegmental membranes in comparison with the areas of more rigid cuticle, presumably because conidia were physically dislodged from intersegmental membranes when larvae moved. Conidia were also exposed to heightened CO 2 to evaluate whether this might influence germination. When conidia on water agar were exposed to heightened CO 2 levels, germinating conidia primarily formed germ tubes while most conidia exposed to ambient CO 2 rapidly formed secondary conidia.
Maternal perception of lactogenesis time: a clinical report.

A study evaluating the time between delivery and the surge in milk production (lactogenesis time) determined whether lactogenesis time (LT) is affected by parity, factors in pregnancy and delivery, and especially cesarean section. Forty-six primiparous mothers and 81 multiparous mothers reported the time of sensation of milk production after delivery. The mean LT in the entire sample was 50 ± 15 hours. The mean LT in 46 primiparous mothers was 59 ± 14 hours, and in 81 multiparous mothers 45 ± 12 hours (by student t test,p<0.01). Mean LT did not decrease as parity increased in the multiparous mothers. By multivariate analysis, mean LT was 44 hours in multiparous mothers who delivered vaginally without medication, 11 hours longer if primiparous, 6 hours longer if delivery by cesarean section, and 13 hours longer if sedative or pain medication were given during labor.
Health information exchange and patient safety

One of the most promising advantages for health information exchange (HIE) is improved patient safety. Up to 18% of the patient safety errors generally and as many as 70% of adverse drug events could be eliminated if the right information about the right patient is available at the right time. Health information exchange makes this possible. Here we present an overview of six different ways in which HIE can improve patient safety-improved medication information processing, improved laboratory information processing, improved radiology information processing, improved communication among providers, improved communication between patients and providers, and improved public health information processing. Within the area of improved medication information processing we discuss drug-allergy information processing, drug-dose information processing, drug-drug information processing, drug-diagnosis information processing, and drug-gene information processing. We also briefly discuss HIE and decreased patient safety as well as standards and completeness of information for HIE and patient safety.
Campylobacter rectus in human periodontitis

Campylobacter rectus (formerly Wolinella recta) in periodontitis lesions was studied relative to age and sex distribution, relationship to disease-active periodontitis, response to periodontal debridement and in vitro antimicrobial susceptibility. Subgingival C. rectus was collected with paper points, transported in VMGA III and plated onto nonselective enriched brucella blood agar and Hammond's selective medium for C. rectus, both incubated anaerobically. C. rectus was recovered from 80% of 1654 periodontitis patients. Although the organism showed similar age and sex occurrence, its proportional recovery in culture-positive adults was inversely related to increasing age (r = 0.999, P < 0.001). The organism was positively associated (summary odds ratio = 2.95) with disease activity in a 24-month longitudinal study of 93 adult periodontitis patients on maintenance therapy. C. rectus decreased from 8.2% to 0.7% following local periodontal debridement of 20 culture-positive adult periodontitis patients. The organism exhibited high in vitro susceptibility to therapeutic levels of tetracycline hydrochloride, metronidazole, penicillin G and ciprofloxacin. These findings further delineate the epidemiology and potential pathogenic role of C. rectus in human periodontitis.
A 100-fps fluorescence lifetime imager in standard 0.13-µm CMOS

A wide-field fluorescence lifetime imager capable of up to 100 frames per second (fps) is presented. The imager consists of a 64-by-64 array of low-noise single photon avalanche diodes (SPADs) in a standard 0.13-μm CMOS process, 4096 time-to-digital converters, and an application specific data path to enable continuous image acquisition at a total output data rate of 42 Gbps. These features combine to enable new lifetime-based diagnostic imaging.
Comprehension of information for informed consent by spouses of surgical patients

The adequacy of comprehension of the information needed for informed consent to participate in research on spouse responses to a husband's or wife's general surgery was assessed. Comprehension of information about the research study by 75 spouses was measured by the Informed Consent Questionnaire containing questions on study purpose, time involvement, nature of participation, risks, benefits, voluntariness, confidentiality, and anonymity. The result showed that 72 of the 75 spouses had adequate comprehension of the information for informed consent. Because adequate comprehension is atypical of most studies, possible reasons for this unexpected result are discussed and then explained within a self-determination theory of informed consent.
Imaging Sunitinib-induced Vascular Changes by DCE-MRI to Schedule Radiotherapy for Murine Renal Cell Carcinoma

Results: Twenty-eight patients were evaluable, all received 50.4 Gy with concurrent chemotherapy. Pneumonitis CTCAEv4 toxicity scores were: 1 grade 3, 3 grade 2, 7 grade 1, and 17 grade 0. Dosimetric factors were not predictive of symptoms. Exhaled NO measured before, at completion, and at restaging were 17.3 (SD 8.5; range 5.5 - 36.7), 16.0 (14.2; 5.8 - 67.7), 14.7 (6.2; 5.5 - 28.0) parts perbillion(ppb)respectively.Eachmeasurementwasmadeintriplicatewithanaveragestandarderrorof0.8ppb.Theratioof exhaledNOattheendofradiotherapyversuspre-treatmentwas3.4(1.7-6.7)forthesymptomaticand0.8(0.3-1.3)fortheasymptomatic (p value = 0.0017). Elevation in exhaled NO preceded peak symptoms by 33 (21 - 50) days. The time to peak symptoms wasfoundtobeinverselyrelatedtotheexhaled NOelevation.TheexhaledNOratio (endversusbefore)wastestedas apredictorof symptomsusingthedatafromthistrialandthek-nearestneighborclassifierschemedescribed.TheNOratiopredictedsymptomatic patients with an average error rate of 8%. Conclusions: Elevation in the exhaled NO at the end of radiotherapy was found to predict for radiation pneumonitis symptoms. Time to peak symptoms was inversely related to the elevation in exhaled NO, higher elevation was associated with a shorter time. Author Disclosure: T. Guerrero, None; J. Martinez, None; M.R. McCurdy, None; M.J. Wolski, None; M.F. McAleer, None.
Location of Adenomyosis in Total Hysterectomy Specimens

Abstract Study Objective To determine the location of adenomyosis in hysterectomy specimens and estimate a risk of leaving the disease in patients undergoing supracervical hysterectomy. Design Retrospective cohort study (Canadian Task Force classification II-2). Setting University teaching hospital. Subjects Total hysterectomy specimens from 32 women. Measurements and Main Results Each patient had six slides representing anterior and posterior cuts of the uterus at the cervix, lower uterine segment, and fundus. Analyzing the six groups separately, no significant difference was seen in the number of nests between anterior and posterior slides at the same uterine level. A substantial difference was noted between each site and all other sites on other uterine levels. Grouping the anterior and posterior together, a significant difference was found in the number of nests between all levels (p Conclusion Adenomyosis has a significant propensity to be present in the uterine fundus but it is extremely rare in the cervix. Supracervical hysterectomy for adenomyosis is unlikely to leave disease in the patient as long as the entire lower uterine segment is excised.
General Treatment of the Effect of Cell Windows in Ellipsometry

A general analysis of the effect of cell windows shows more error terms in each of the four ellipsometry zones than is found in the conventional small-retardation wave-plate approximation. The value of ψ from a two-zone average requires a correction that is generally dependent on both the window and the reflecting surface under study. A difference of the flux transmission in the s direction from that in the p direction as small as 10−6 leads to an appreciable correction ∼0.06°. An experimental procedure to correct for window error is described and is applied to three different types of windows with Δ errors from 0.05° to 1.5°.
p53-dependent global genomic repair of benzo[a]pyrene-7,8-diol-9,10-epoxide adducts in human cells.

The global genomic repair of DNA adducts formed by the human carcinogen (±)- anti- benzo[ a ]pyrene-7,8-diol-9,10-epoxide (BPDE) has been studied by 32P-postlabeling in human fibroblasts in which p53 expression can be regulated. At low BPDE adduct levels (10–50 adducts/108 nucleotides), repair was rapid and essentially complete within 24 h in p53+ cells, whereas no repair was detected within 72 h in similarly treated p53− cells. At 10-fold higher BPDE adduct levels, repair under both conditions was rapid up to 8 h, after which a low level of adducts persisted only in p53− cells. These results demonstrate a dependence on p53 for the efficient repair of BPDE adducts at levels that are relevant to human environmental exposure and, thus, have significant implications for human carcinogenesis.
Input shaper design for double-pendulum planar gantry cranes

Manipulating payload with gantry cranes can be difficult given the inherent system flexibility. Gantry crane dynamics can often be effectively modeled as a single linear flexible mode. However, if the crane is equipped with a large-mass hook and the payload is sufficiently light, then the dynamics can become complicated by double-pendulum effects. This paper presents a method for determining the contribution of the second pendulum mode to the overall dynamic response. Furthermore, an input shaping scheme is developed to reduce residual oscillations. This control method utilizes the double-pendulum dynamics to determine the parameters of the input shaping algorithm.
Wintertime Nonbrightband Rain in California and Oregon during CALJET and PACJET: Geographic, Interannual, and Synoptic Variability

Abstract An objective algorithm presented in White et al. was applied to vertically pointing S-band (S-PROF) radar data recorded at four sites in northern California and western Oregon during four winters to assess the geographic, interannual, and synoptic variability of stratiform nonbrightband (NBB) rain in landfalling winter storms. NBB rain typically fell in a shallow layer residing beneath the melting level ( ∼6 km MSL). The shallow NBB echo tops often resided beneath the coverage of the operational Weather Surveillance Radar-1988 Doppler (WSR-88D) scanning radars yet were still capable of producing flooding rains. NBB rain contributed significantly to the total winter-season rainfall at each of the four geographically distinct sites (i.e., 18%–35% of the winter-season rain totals). In addition, the rainfall observed at the coastal mountain site near Cazadero, California (CZD), during each of four ...
Neoclassical transport in Elmo Bumpy Torus (EBT)

The calculation in this paper clarifies the ordering of transport regimes in Elmo Bumpy Torus (EBT), identified as one collisional and two collisionless regimes, plateau and banana. Explicit analytic estimates of the transport rates in the plateau regime are obtained.
Chemical approaches to studying transcription

Gene transcription is one of the most important and complex processes in biology but great advances are being made into understanding its molecular mechanisms. Selective modulators of nuclear receptors that can regulate transcription of specific genes allow for the comparative analysis of different states of transcription. Techniques to monitor the binding of proteins to DNA leading up to transcription have also increased our knowledge of the events involved in the initiation of transcription. While still in its infancy, the use of chemical tools to study transcription shows great promise in dissecting a complex molecular process.
Oblate Deltahedra in Dimetallaboranes: Geometry and Chemical Bonding

A new series of nonspherical and very oblate deltahedra, conveniently called the oblatocloso deltahedra, is found in dimetallaboranes among which the dirhenaboranes Cp2Re2B(n-2)H(n-2) (8 <or= n <or= 12) are the prototypes. The D(6h) hexagonal bipyramid is the first member of this series (n = 8). However, the higher members of the series are not bipyramids but are derivable from them by a number of diamond-square-diamond processes. A viable model for the skeletal bonding in the oblatocloso dimetallaboranes can be developed if the two metal vertices, typically degree 6 or 7 vertices, are assumed each to contribute five internal orbitals rather than the three internal orbitals assumed by the Wade-Mingos rules. This leads to 2n + 4 actual skeletal electrons for an n vertex oblatocloso dimetallaborane rather than the Wadean 2n - 4 skeletal electrons. The surface bonding of an n vertex oblatocloso dimetallaborane then consists of n three-center two-electron bonds similar to that in corresponding isocloso metallaboranes thereby leaving four orbitals and four electrons for a metal-metal double bond inside the deltahedron. Removal of one or two boron vertices from oblatocloso deltahedra leads to oblatonido and oblatoarachno dimetallaboranes, respectively, having the same number of skeletal electrons as the oblatocloso deltahedra from which they are derived.
Electronic Communication Training: Reconciling Gaps Created by the Virtual Office

The virtual organization is one result of the rapid advances of technology. These advances, however, bring about setbacks when communicating electronically—primarily a loss of face-to-face interaction. Yet interpersonal skills are still deemed one of the most desirable communication skills in today's workplace. A gap analysis of the traditional versus the virtual office reveals that voids exist when communicating solely electronically. Electronic communication training is essential in order to eliminate these voids and lessen the chance for unclear messages, enhance “faceless” interactions, and avoid communication overload. Therefore, it is incumbent upon educators and trainers to augment development programs with electronic communication training in order for employees to be prepared for the challenges of the virtual office.
Frames of War: When Is Life Grievable?, by Judith Butler

Judith Butler, Frames of War: When Is Life Grievable? (London: Verso, 2009), viii + 193 pp. $26.95. How can one properly frame a review of a book about framing? Topically, I could tell you that thi...
Reducing hospital noise with sound acoustic panels and diffusion: a controlled study

Noise has been identified as a major stressor in hospitals,1 ,2 with ambient noise frequently exceeding recommended levels set by the WHO3 and reportedly as high as alarm clocks.4 ,5 Although hospitals frequently attempt to reduce noise through traditional methods such as shielding the patient (eg, closing doors), moving equipment or altering staff behaviours, these approaches disrupt workflow and ignore the realities of sound generation required in modern hospitals, which potentially limits their impact on quality and patient safety. An unexplored method of reducing hospital noise borrowed from other industries is to use sound acoustic panels that diffuse noise rather than attempt to eliminate it.6 We performed a pilot study to determine whether strategically placed, sound acoustic panels applied in hospitals would acutely reduce noise in hallways adjacent to patient rooms. If true, this option could serve as an architectural design solution to enhance patient care and experience during hospitalisation. We conducted an observational, controlled study assessing sound levels on an active inpatient telemetry unit. Due to physical nature of sound acoustic panels, patients and staff were not blinded. Placement of panels and acoustic equipment met all institutional building management policies and national codes (figure 1). The inpatient telemetry unit is organised as two central parallel hallways with architecturally identical patient rooms on both sides. Walls and floors were hard surfaces designed for ease …
Invertebrate Biomass in Mowed and Unmowed Fields of Canaan Valley

Abstract Few data exist on invertebrate populations in farmland habitats of the Appalachian Mountains. However, invertebrate biomass and taxonomic composition may influence the potential for birds to reproduce. We collected invertebrates using sweepnets on 3 idle pastures and 3 idle hayfields in the Canaan Valley National Wildlife Refuge, WV. To evaluate the effects of mowing on invertebrate biomass, half of each field was mowed in August 1999 after grassland birds had finished nesting. In 2000, we collected terrestrial invertebrates on the mowed and non-mowed portions of each field. We documented 25 invertebrate families from 12 orders. Taxa in the orders Coleoptera (beetles), Diptera (flies), Homoptera (leafhoppers), and Orthoptera (grasshoppers and crickets) were the most abundant. Invertebrate biomass (g/150 passes of a sweep net) was similar (P = 0.763) between mowed (mean = 0.4302, SE = 0.0509) and unmowed (mean = 0.4704, SE = 0.0716) treatments. Biomass was similar between hayfields and pastures fo...
What can NLP tell us about BioNLP

The goal of this work is to apply NLP techniques to the field of BioNLP in order to gain a better insight into the field and show connections and trends that might not otherwise be apparent. The data we analyzed was the proceedings from last decade of BioNLP workshops. Our findings reveal the prominent research problems and techniques in the field, their progression over time, the approaches that researchers are using to solve those problems, insightful ways to categorize works in the field, and the prominent researchers and groups whose works are influencing the field.
Advances in Imaging Cystic Fibrosis Lung Disease

Cystic fibrosis (CF) is a life shortening, multiorgan disease, in which morbidity and mortality are dominated by pulmonary pathologies, including mucous obstruction, chronic lung infections, progressive bronchiectasis, and declining lung function. Promising new therapies, including those that target the cystic fibrosis transmembrane conductance regulator (CFTR) protein, have shown impressive efficacy in treating CF patients with specific genotypes. While spirometry is the clinical gold standard for evaluating CF lung disease, it has known insensitivities to mild lung disease and statistical weaknesses in small cohorts. Imaging has begun to play an important role in evaluating the structural abnormalities associated with CF lung disease progression. X-ray computed tomography (CT) has been established as a modality with validated metrics to evaluate disease severity, even in young patients with mild disease. Magnetic resonance imaging (MRI), as a nonionizing alternative, has very strong potential for simila...
Abstract 18273: Cardiomyocytes Inhibit the Growth of Lung and Breast Cancer Cells but Fail to Abrogate the Proliferation of Melanoma Cells

The adult heart is an organ resistant to primary cancer formation and secondary metastatic invasion. Rhabdomyosarcomas are rare and the majority of primary tumors are benign and restricted to the a...
Forest Degradation and Fragmentation within Celaque National Park, Honduras

Finding effective means to halt or slow deforestation in natural areas is of great concern throughout the world. In the past few decades, the increase in the number of protected areas in Latin America has been particularly dramatic (Bates and Rudel 2000). Indeed, the tropical rain forests located within these protected areas have increased from less than 200,000 km2 in 1965, to over 1,100,000 km2 in 1990 (Harcourt and Sayer 1996). We chose one of these protected areas, Celaque National Park in Honduras, to conduct an empirical case study on the effectiveness of park establishment in halting deforestation. Established in 1987, Celaque National Park encompasses ~266 km2. Much controversy exists regarding parks as management regimes (Bruner et al. 2001). Although the effects of protected-area establishment on local livelihoods is well documented, there are few case studies that examine whether parks experience different rates and patterns of land-cover change compared to non-protected areas. Geographers have the perfect suite of tools to undertake such studies.
Moving toward Collective Mindsets: An Investigation of Group-based Synchrony in Work Teams

The keys to creating effective team performance have long been under investigation by researchers. Past research identifies social cohesion as an important precursor, but how to achieve social cohe...
The Early Days of Neutron Scattering

I am sure that Bertram Brockhouse would join me, if he were present with us, in saying how immensely grateful we are to the Royal Swedish Academy of Sciences for affording us the high honor of being named Nobel Laureates in recent days. Being selected as such is a dream for any scientist who hopes that his work will prove useful to others. It is especially gratifying to me to have met at this symposium with so many of you who have contributed greatly to bringing this field of neutron scattering to its present state of usefulness and prominence.
Induction Motor Bearing Fault Analysis Using a Root-MUSIC Method

This paper describes a new diagnosis approach, the Root-Multiple Signal Classification (MUSIC) (RM) method, for identification of the progressive cracking in the bearing of induction motors. This approach has several advantages compared with the stator current spectral analysis using the conventional Periodogram method. Indeed, the main advantage of this approach is its very good frequency resolution for a very short acquisition time, something impossible to achieve with the conventional method. However, in order to reduce the computation time, which is the main drawback of the RM method, this method will be applied to only a specified frequency band; one that carries information about the sought fault. Experimental results show the effectiveness of the RM method on the reliability of the incipient bearing fault detection.
Justice: A Post-9/11 Theory

All acts of violence are rooted in injustice, promote injustice, and sustain injustice. Whether they are individual or social acts, that is, personal or systemic acts of violence, whether they are against one person, several persons, a community, a whole group defined by any given characteristic or circumstance, or a nation—acts of violence result in injustice and oppression.1 Violence is not the only form of oppression but all forms of oppression impinge on each other, reinforcing each other. Violence, therefore, is at play in exploitation, prejudice and discrimination, marginalization, and powerlessness.2 It is my contention that oppression destroys the ontological social fabric of humanity, that it violently tears asunder communities, peoples, nations: all relationships.
Differences in midline fascial forces exist following laparoscopic and open transversus abdominis release in a porcine model

Posterior component separation herniorrhaphy via transversus abdominis release (TAR) permits midline reapproximation of large fascial defects. To date, no report delineates the reduction in tensile force to reapproximate midline fascia following TAR. We hypothesized that open and laparoscopic TAR would provide similar reductions in midline reapproximation forces in a porcine model. Under general anesthesia, a 20-cm midline laparotomy was created and bilateral lipocutaneous flaps were raised to expose the anterior rectus sheath. Five stainless steel hooks were placed at 1-cm intervals lateral to the midline at three locations: 5 cm above, at, and 5 cm below the umbilicus bilaterally. Baseline force measurements were taken by pulling each lateral point to midline. Laparoscopic TAR was performed unilaterally by incising the parietal peritoneum and transversus muscle lateral to the linea semilunaris. Open TAR was performed contralaterally, and force measurements were repeated. Comparisons were made to baseline and between the groups. Following laparoscopic TAR, 87 % (13/15) of points showed significant reduction compared to baseline forces, whereas only 20 % (3/15) of open TAR points had significant force reductions. Compared to open TAR, three locations favored the laparoscopic approach [1 cm lateral to midline, 5 cm above the umbilicus (p = 0.04; 95 % CI 0.78–1.00), 2 cm lateral to midline at the umbilicus (p = 0.04; 95 % CI 0.80–1.00), and 1 cm lateral to midline 5 cm below the umbilicus (p = 0.05; 95 % CI 0.79–1.00)]. The mean length of TAR was longer for laparoscopic than open at 27.29 versus 19.55 cm (p < 0.0001; 95 % CI 6.46–9.02). Open TAR reduced midline tensile force at few locations, suggesting that the mechanism by which TAR facilitates herniorraphy may not solely be through reductions in linea alba tensile forces. At specific locations, laparoscopic TAR provides superior reduction in midline closure force compared to open TAR, likely as a result of a longer muscle release.
Altered Oncogenic Fitness of Imatinib- and Dasatinib-Resistant BCR-ABL Mutants Is Due to Differential Intrinsic Kinase Activity and Signaling Pathway Selection Defined by Phosphoproteome Profiling.

Point mutations in the kinase domain of BCR-ABL are the most common cause of resistance to imatinib therapy in CML. E255K and T315I are detectable before the initiation of imatinib therapy in a small population of CML patients, suggesting that certain imatinib-resistant BCR-ABL mutants display altered biological fitness relative to wild-type p210 BCR-ABL. To test this hypothesis, we performed primary murine bone marrow transformation assays using BCR-ABL-expressing retroviruses. In a survey of six clinically imatinib-resistant mutations (Y253F, Y253H, E255K, E255V, T315I, M351T) as well as five additional mutations that confer in vitro resistance to the dual SRC/ABL inhibitor dasatinib (L248R, V299L, T315A, F317L, F317V), we identified several that altered oncogenic fitness either positively or negatively relative to p210. To elucidate the molecular basis for altered transformation potential, we examined the kinase activity of p210 versus mutant full-length BCR-ABL. Enzyme kinetics studies with an optimized Abl peptide substrate as well as gel-based in vitro kinase assays illustrated that intrinsic kinase activity does explain some, but not all, of the mutant oncogenic potency phenotypes. The imatinib- and dasatinib-resistant mutant T315I, for instance, was a gain-of-fitness mutant in the bone marrow assay but exhibited a three-fold lower Vmax than p210. In contrast, T315A, a dasatinib-resistant mutation at the T315 gatekeeper residue, exhibits reduced transforming potential relative to wt p210 and is completely unable to phosphorylate Abl substrates in the kinase assays, although it does retain the ability to autophosphorylate. Subsequent kinase assays on immunoprecipitations from stably expressing IL-3-independent Ba/F3 cells illustrated that certain mutants bind and phosphorylate distinct substrates from p210. We further delineated signaling differences between p210 and the mutant panel by utilizing a mass spectrometry-based global phosphorylation profiling technique. Trypsinized proteins from stably expressing p210 and mutant Ba/F3 cells were immunoprecipitated using anti-phosphotyrosine antibodies, then identified and quantified by two dimensional mass spectrometry. Phosphorylation of specific substrates correlates with gain- or loss-of fitness observed in the bone marrow assay. We conclude that certain BCR-ABL kinase domain mutations, in addition to conferring drug resistance, also affect the oncogenic potency of BCR-ABL by altering intrinsic kinase activity as well as downstream targets. Elucidation of alternative signaling pathways activated by these mutants by the combination of biochemical and mass spectrometric methods may provide novel therapeutic targets for imatinib- and dasatinib-resistant CML.
Florid erythrophagocytosis by neutrophils in peripheral blood.

![Figure][1] A 3-year-old boy presented with abdominal pain, fever, diarrhea, and dark urine for a few days. Complete blood count showed leukocytosis (white blood cells, 18.62 × 109/L), anemia (hemoglobin, 8.9 g/dL), and thrombocytopenia (platelets, 134 × 109/L). Lactate dehydrogenase,
Revascularization for Silent Myocardial Ischemia

Silent myocardial ischemia, defined as the presence of ischemia without symptoms, is common in patients with coronary artery disease (CAD). The presence and extent of silent myocardial ischemia predicts poor prognosis in patients with or without known CAD. However, the mechanism by which silent myocardial ischemia confers an increased risk of adverse cardiovascular events remains unknown. Current recommendations for revascularization to improve outcomes in asymptomatic patients with stable CAD and moderate to severe ischemia are based solely on the rational link between inducible ischemia and prognosis, and on data from observational studies. No modern randomized clinical trial has definitively established the value of revascularization in patients with stable CAD with moderate to severe ischemia. Ongoing studies may provide a definitive answer to the question of whether myocardial ischemia (silent or not) should be used as the basis for an invasive approach (including revascularization) in the management of patients with stable CAD.
(Sub)urban sexscapes: geographies and regulation of the sex industry

In regard to sex, Foucault (1976/1978) once stated that ‘where there is power, there is resistance’ (p. 96). This relationship between the power at various levels of government (local, regional and...
Immunochemical analyses of the myoblast membrane and lineage.

We have been using monoclonal antibodies to analyse cells by immunofluorescence microscopy in an effort to understand the molecules and events on the myoblast membrane that are germane to their differentiation. What follows is a summary of some of our findings.
Highly Soluble p-Terphenyl and Fluorene Derivatives as Efficient Dopants in Plastic Scintillators for Sensitive Nuclear Material Detection.

Plastic scintillators are commonly used as first-line detectors for special nuclear materials. Current state-of-the-art plastic scintillators based on poly(vinyltoluene) (PVT) matrices containing high loadings (>15.0 wt %) of 2,5-diphenyloxazole (PPO) offer neutron signal discrimination in gamma radiation background (termed pulse shape discrimination, PSD), however, they suffer from poor mechanical properties. In this work, a series of p-terphenyl and fluorene derivatives were synthesized and tested as dopants in PVT based plastic scintillators as possible alternatives to PPO to address the mechanical property issue and to study the PSD mechanism. The derivatives were synthesized from low cost starting materials in high yields using simple chemistry. The photophysical and thermal properties were investigated for their influence on radiation sensitivity/detection performance, and mechanical stability. A direct correlation was found between the melting point of the dopants and the subsequent mechanical properties of the PVT based plastic scintillators. For example, select fluorene derivatives used as dopants produced scintillator samples with mechanical properties exceeding those of the commercial PPO-based scintillators while producing acceptable PSD capabilities. The physical properties of the synthesized dopants were also investigated to examine their effect on the final scintillator samples. Planar derivatives of fluorene were found to be highly soluble in PVT matrices with little to no aggregation induced effects.
Age differences in self-set goal effects for memory

Research has shown that goal setting leads to gains in memory performance and memory self-efficacy across adulthood when goals are set by experimenters and accompanied by positive feedback. However, self-set memory goals have had less consistent impact. This research extended past studies on aging and memory goals to examine the impact of self-set goals using anchors to guide goal selection. Two trials of name, text, and list recall were administered to younger and older adults, comparing goal and no-goal groups. After baseline, participants assigned to the goal group set personal goals for memory gain on a second, post-goal trial for each of the three tasks. Anchoring for goal-setting was used to encourage the selection of realistic, yet challenging goals. Younger and older participants set comparable goals. Only younger adults showed a motivational response (higher gains across trials for goals than no goals), even though older adults reported being just as committed to their personal goals. Older adults may have failed to show reliable goal-related gains because no positive feedback was offered or because they were unable to activate effective strategies for improved performance.
Elite Competition, Factionalism and Strongman Governance in a Central China Village

AbstractThis study examines the elite political competition in a large agrarian village in Hubei Province. Although known locally as well-governed, this village was actually a bifurcated political community with a host of problems. The power struggle between a few members of the village’s political elite in the past two decades focused on the office of village Party secretary and produced a polarized politics of factionalism. The town Party committee played a crucial role in selecting the village’s Party secretary for economic development with dubious results. This study also examines how and why a strongman Party secretary could hold on to power for 16 years despite an increasing opposition. It reveals the governing dilemma for a village that was hard to govern and the unintended consequences of the Party’s recruitment policy for village leaders. Through the elite competition for the past two decades this study aims to capture a total picture of the village politics including its political ecology, agenc...
Clinical performance of a next-generation sequencing assay (ThyroSeq v2) in the evaluation of indeterminate thyroid nodules.

Background Molecular testing with the Thyroseq v2 next generation sequencing panel (“Thyroseq”) is used to estimate the risk of cancer in indeterminate thyroid nodules. Methods We analyzed 156 indeterminate thyroid nodules evaluated with Thyroseq, across 3 institutions. Thyroseq data and surgical pathology were matched via pathologic re-review. A result was considered Thyroseq positive if molecular alterations were annotated on the report with malignancy probability >30%. Performance characteristics were estimated using Bayes theorem. Results The Thyroseq-negative call rate was 65% (102/156). On surgical pathology, 16% (10/63) of nodules were malignant. The positive predictive value of a Thyroseq-positive result was 22% (8/37; if 2 noninvasive follicular thyroid neoplasm with papillary-like nuclear features are counted as malignant, 27%, 10/37). There was 1 false-negative result (negative predictive value 96%, 22/23). The most common mutation was NRAS (19/37) with a positive predictive value of 7% (1/15). The positive predictive value of all RAS mutations (HRAS, KRAS, NRAS) was 9% (2/22). The second most common mutation, BRAF V600E, had positive predictive value of 100% (3/3). Conclusion We report an external analysis of Thyroseq performance in the evaluation of indeterminate thyroid nodules. These data indicate that Thyroseq is likely to offer high negative predictive value but low positive predictive value. Many genetic alterations appear to be nonspecific for malignancy, and positive results should be interpreted with caution. These findings have implications for the management of indeterminate thyroid nodules profiled with Thyroseq.
Colonoscopy procedural volume increases adenoma and polyp detection rates in gastroenterologytrainees

Colonoscopy procedural volume increases adenoma and polyp detection rates in gastroenterologytrainees
Interpretation of clinical endpoints in trials of acute myeloid leukemia

Treatment regimens for acute myeloid leukemia (AML) have remained largely unchanged until recently. Molecular advances have opened the door to targeted therapies, many of which are in late-phase clinical trials. As new therapeutic opportunities arise, it is appropriate to review key aspects of clinical trial design, statistical interpretation of outcomes, and methods of data reporting. Complete remission and overall survival (OS) are common primary endpoints in early-phase AML clinical trials. OS and event-free survival are frequent primary endpoints in phase 3 trials. Clinical trials are designed to address the primary endpoint using prespecified α and power levels. Interpretation of additional endpoints (eg, secondary endpoints and subgroup analyses) must be viewed in light of a trial's statistical design. Furthermore, variations in reporting of endpoints must be considered in order to understand trial outcomes. Time-to-event endpoints are typically reported using Kaplan-Meier curves, which are visually informative. Statistical data derived from these curves can be complex, and a variety of factors may impact interpretation. The purpose of this review is to discuss the nuances of common AML trial endpoints and their data presentation to better inform evaluation and understanding of clinical trial data.
THE CREATIVE PSYCHOSOCIAL GENOMIC HEALING EXPERIENCE (CPGHE) AND GENE EXPRESSION IN BREAST CANCER PATIENTS: A FEASIBILITY STUDY.

Abstract Background Biomarkers associated with inflammation and immune function are increasingly being used to examine mechanisms of the effects of mind-body therapies. Less researched are biomarkers associated with cognitive and executive functioning in the study of mind-body therapy mechanisms and effects. This study explored the feasibility of recruiting breast cancer patients (BCPs) and implementation fidelity of participation in a research project utilizing the 4-stage Creative Psychosocial Genomic Healing Experience (CPGHE), a mind-body protocol that is theorized to create epigenetic effects via targeted psychological change in emotional triggers in coping with cancer. Methods Eight BCPs were identified as eligible (stages I, II, III, early phases of treatment) and five consented to one of two intervention groups (allocated to a single session or two sessions of CPGHE). Blood draws were examined pre- and post-intervention for a stress/inflammation gene expression marker, Nuclear Factor kappa-B (NF-kB), and three markers associated with synaptic plasticity undergirding cognitive and executive functioning: Early Growth Response 1 (EGR1), activity-regulated cytoskeleton-associated protein (Arc), and brain-derived neurotrophic factor (BDNF). Results One consented BCP dropped out due to illness. The remaining four adhered to the 4-stage CPGHE protocol and found the CPGHE experience beneficial. Blood samples for the gene expression results were collected and processed according to planned protocol without incident. Conclusion Implementing the CPGHE and achieving good adherence among a sample of BCPs is feasible. Processing of blood samples collected from BCPs for gene expression data is also feasible.
Probable Inference and Justifying Induction

In his essay “A Theory of Probable Inference,” Pierce formulates induction in the following syllogistic form: S1, S2,..., Sn form a numerous random sample of the instances of M, A proportion r of S1,... Sn are instances of P, Hence, probably and approximately, a proportion r of instances of M are instances of P.1
Birefringence Analysis of Inhomogeneous Swelling in Filled Elastomers

The inhomogeneous swelling of an elastomeric matrix containing isolated, spherical filler particles has been described in detail elsewhere [7]. In this paper, the birefringence resulting from the spherically symmetric swelling field is considered in detail. Equations are derived that predict the retardation of polarized light that would be observed in a plane. Experimental results on cross-linked natural rubber containing bonded glass spheres and swollen in benzene and o-dichlorobenzene are given.
Stabilization of discrete-time linear systems by delay independent truncated predictor feedback

For a discrete-time linear system with input delay, the predictor feedback law is the product of a feedback gain matrix with the predicted state at a future time instant ahead of the current time instant by the amount of the delay, which is the sum of the zero input solution and the zero state solution of the system. The zero state solution is a finite summation that involves past input, requiring considerable memory in the digital implementation of the predictor feedback law. The truncated predictor feedback, which results from discarding the finite summation part of the predictor feedback law, reduces implementation complexity. The delay independent truncated predictor feedback law further discards the delay dependent transition matrix in the truncated predictor feedback law and is thus robust to unknown delays. It is known that such a delay independent truncated predictor feedback law stabilizes a discrete-time linear system with all its poles at z = 1 or inside the unit circle no matter how large the delay is. In this paper, we first construct an example to show that the delay independent truncated predictor feedback law cannot compensate too large a delay if the open loop system has poles on the unit circle at z ≠ 1. Then, a delay bound is provided for the stabilizability of a general linear system by the delay independent truncated predictor feedback.
A Research Agenda for Assessment and Management of Psychosis in Emergency Department Patients

Author(s): Peltzer-Jones, Jennifer; Nordstrom, Kimberly; Currier, Glenn; Berlin, Jon S.; Singh, Cynthia; Schneider, Sandra | Abstract: Introduction: Emergency departments (ED) manage a wide variety of critical medical presentations. Traumatic, neurologic, and cardiac crises are among the most prevalent types of emergencies treated in an ED setting. The high volume of presentations has led to collaborative partnerships in research and process development between experts in emergency medicine (EM) and other disciplines. While psychosis is a medical emergency frequently treated in the ED, there remains a paucity of evidence-based literature highlighting best practices for management of psychotic presentations in the ED. In the absence of collaborative research, development of best practice guidelines cannot begin. A working group convened to develop a set of high-priority research questions to address the knowledge gaps in the care of psychotic patients in the ED. This article is the product of a subgroup considering “Special Populations: Psychotic Spectrum Disorders,” from the 2016 Coalition on Psychiatric Emergencies first Research Consensus Conference on Acute Mental Illness. Methods: Participants were identified with expertise in psychosis from EM, emergency psychiatry, emergency psychology, clinical research, governmental agencies, and patient advocacy groups. Background literature reviews were performed prior to the in-person meeting. A nominal group technique was employed to develop group consensus on the highest priority research gaps. Following the nominal group technique, input was solicited from all participants during the meeting, questions were iteratively focused and revised, voted on, and then ranked by importance.Results: The group developed 28 separate questions. After clarification and voting, the group identified six high-priority research areas. These questions signify the perceived gaps in psychosis research in emergency settings. Questions were further grouped into two topic areas: screening and identification; and intervention and management strategies. Conclusion: While psychosis has become a more common presentation in the ED, standardized screening, intervention, and outcome measurement for psychosis has not moved beyond attention to agitation management. As improved outpatient-intervention protocols are developed for treatment of psychosis, it is imperative that parallel protocols are developed for delivery in the ED setting.
Short Term Drought Conditioning Influences Adventitious Rooting of Firebush and Fraser's Photinia Stem Cuttings

Abstract Experiments investigated the influence of drought conditioning stock plants and an auxin-based plant growth regulator (PGR) on adventitious root formation of terminal stem cuttings taken f...