cssi/SciSciGPT-SciSciNet huggingface dataset:
Serious Infectious Complications Related to Extremity Cast/Splint Placement in Children

Abstract Background Extremity injuries necessitating splinting or casting are commonly seen in the emergency department (ED) setting. Subsequently, it is not uncommon for patients to present to the ED with complaints related to an extremity cast or splint. Objective To present a literature-based approach to the identification and initial management of patients with possible infectious cast/splint complications in the ED setting. Case Reports We present two cases of serious infectious complications arising from extremity cast/splint placement seen in a single pediatric ED: a case of toxic shock syndrome in an 8-year-old child, and a case of necrotizing fasciitis resulting in upper extremity amputation in a 3-year-old child. Conclusions/Summary A wide spectrum of potential extremity cast/splint infectious complications may be seen, which include limb- or life-threatening infections such as toxic shock syndrome and necrotizing fasciitis. Simply considering these diagnoses, and removing the cast or splint to carefully inspect the affected extremity, are potential keys to early identification and optimal outcome of cast/splint complications. It is also prudent to maintain particular vigilance when treating a patient with a water-exposed cast, which may lead to moist padding, skin breakdown, and potential infection. In patients with suspected serious infections, aggressive fluid management and antibiotic therapy should be initiated and appropriate surgical consultation obtained without delay.
West Mexican Stelae from Jalisco and Nayarit

The process of Mesoamerican cultural expansion into western and northwestern Mexico has been a subject of speculation and investigation for over three centuries. Although many cultural traits have been "implicated" in this process, the practice of erecting stelae has not been one of them. Fieldwork by the author in Jalisco and Nayarit over the past 14 years has resulted in the discovery of 48 stone monuments which are proposed to be rustic versions of the usually more sophisticated stelae associated with cultures of central Mesoamerica. These west Mexican stelae are described and discussed in terms of their context, date, and possible function. Similar stone monuments from other sites in western and northwestern Mexico are also described, and relevant ethnohistoric data are presented. Finally, the diffusion of the practice of erecting stelae is discussed in relation to the process of mesoamerieanization in western and northwestern Mexico.
Polarization properties of GaN nanowire lasers

The polarization properties of GaN nanowire lasers are studied experimentally by analyzing their end-facet emission. We demonstrate that the polarization state varies for different transverse modes. Linear and elliptical polarizations are observed in our measurements.
13.2 nm table-top inspection microscope for extreme ultraviolet lithography mask defect characterization

We report on a reflection microscope that operates at 13.2-nm wavelength with a spatial resolution of 55±3 nm. The microscope uses a table-top EUV laser to acquire images of photolithography masks in 20 seconds.
Novel oral anticoagulants: What dermatologists need to know

The development of novel oral anticoagulants provides clinicians and patients a welcome alternative to the challenges of warfarin therapy. Dermatologists must be aware of the potential impact of novel oral anticoagulants on their surgical and medical practice. This review provides a concise summary of the novel oral anticoagulants for dermatologists with particular emphasis on: (1) the pharmacokinetic properties of these drugs and how they differ from warfarin, (2) suggested management during cutaneous surgery, (3) adverse drug interactions with commonly prescribed medications in dermatology, and (4) potential use within dermatology for treatment of disorders of cutaneous thrombosis.
Toroidal coil models for transcutaneous magnetic simulation of nerves

A novel design of coils for transcutaneous magnetic stimulation of nerves is presented. These coils consist of a toroidal winding around a high-permeability material (Supermendur) core embedded in a conducting medium. Theoretical numerical calculations are used to analyze the effect of the design parameters of these coils, such as coil width, toroidal radius, conducting layer thickness and core transversal shape on the induced electric fields in terms of the electric field strength and distribution. Results indicate that stimulation of nerves with these coils has some of the advantages of both electrical and magnetic stimulation. These coils can produce localized and efficient stimulation of nerves with induced electric fields parallel and perpendicular to the skin similar to surface electrical stimulation. However, they retain some of the advantages of magnetic stimulation such as no risk of tissue damage due to electrochemical reactions at the electrode interface and less uncomfortable sensations or pain. The driving current is reduced by over three orders of magnitude compared to traditional magnetic stimulation, eliminating the problem of coil heating and allowing for long duration and high-frequency magnetic stimulation with inexpensive stimulators.
Localization of primordia within the dorsal mesothoracic disc of drosophila.

Distal regions or “marginal ridge” areas of the dorsal mesothoracic disc of mature Drosophila larvae, not previously included in fate maps, were marked by microcauterization in situ. Structures assumed to have primordia in the distal half of the disc (mesopleura, pteropleura, arch, ventral scutellum, ventral wing hinge and wing proper) are either missing, deficient, or damaged among adults surviving the operation. In contrast, neither the dorsal wing hinge nor mesonotum, which are known to have primordia in the proximal half of the disc, are similarly affected. The pattern of distribution of deformities in surviving adults indicates that (a) the anlage of the mesopleural sclerite is located in the distal edge portion or “marginal ridge” of the disc, (b) anlagen of pteropleura, arch and ventral scutellum may also be tentatively assigned to this location, (c) there are significantly high associations between deformities affecting the pteropleura and the ventral wing hinge, and (d) the anlage of the deep phragma of the postnotum may be more closely related to the first abdominal tergite than to the dorsal mesothoracic disc. The distal localization of pleural, arch, and ventral scutellar anlagen corresponds to the physical separation from mesonotal anlagen predicted from an earlier statistical analysis of genetic mosaics; i.e., these presumptive sclerites are separated from the mesonotal anlagen by the anlagen of the wing in the “pouch” area of the disc. The new information has been incorporated into a hypothetical fate map of the disc, which includes anlagen plans suggested by previous authors.
Enhanced video compression with standardized bit stream syntax

With the establishment of video coding standards and the expanding use of video codecs, it is necessary to consider the designs of encoders and decoders as two individual problems instead of the conventional concurrent design approach. The authors formulate the two separate problems and examine some possible ways to enhance performance over previous algorithms. Given the decoding process and the channel, the encoding problem can be formulated as a constrained optimization problem. The dual of the encoding problem, to decode the compressed video data generated by an existing encoder, can be formulated as an optimal estimation problem given the encoded bit stream. Examination of these two problems provides the pathway to the design of enhanced compatible encoding and decoding schemes. >
Using metaphor to deal with human immunodeficiency infection and infertility.

In the preceding article, “Human immunodeficiency virus and assisted reproduction: reconsidering evidence, reframing ethics” by Anne Drapkin Lyerly and Jean Anderson, a strong case is made for not categorically excluding individuals with HIV infection from infertility services (1). In the past year Howard Minkoff and Nanette Santoro (2) as well as Deborah Anderson (3) have made similar arguments for changes in public policy and practice. In the past, the reasons for advising HIV-positive patients against unprotected intercourse, pregnancy, and childbirth or infertility treatment were straightforward and made sense. When acquired immune deficiency syndrome (AIDS) was first confirmed in the United States in 1981, it was a poorly understood, fatal disease with no known treatment or cure. Sexual partners could infect one another while trying to conceive, and the disease was transmitted from mother to infant in over 25% of pregnancies—and the prognosis of the infected child was poor. Thus, pregnancy seemed ill advised: not only did the infected patient have a short life expectancy, but conception involved the possibility of infecting both the partner and the offspring with the fatal disease. The fear of accidental infection of health care workers and other patients, and the possibility of contamination in the laboratory have also been factors. Universal precautions and years of experience with good safety records have quieted but not dismissed these concerns. In the early years after it was first recognized, HIV infection was associated largely with male homosexuals and intravenous drug users. Concerns about reproduction were not a high priority. Now heterosexual intercourse appears to have become a major route of HIV infection. Women at reproductive age make up a large number of new disease cases, and many of these patients are getting pregnant or seeking infertility services. The Lyerly and Anderson article “reframes” ethics to provide reasonable and convincing arguments in favor of new policies, but it is the facts that do most of the work. The epidemiology, treatment, and prognosis of HIV infection have changed so markedly that none of the arguments once used to justify avoiding pregnancy or infertility treatment have the force they once had. Treatment of HIV infection has improved dramatically in the past 5 years or so, lowering the death rates and improving survival. By treating both the pregnant woman and the newborn with antiviral drugs, vertical transmission from mother to infant can be reduced markedly to about 2%. When only the woman carries the virus, infection of her partner can be avoided by the use of artificial insemination with the partner’s sperm; when the man is HIV positive, processing of the semen to free it of virus is now an option. Furthermore, the Supreme Court’s interpretation of the Americans with Disabilities Act (ADA) suggests that it would be illegal to deny infertility treatment to a couple solely on the basis of one or both partners having HIV infection.
Effects of Intranasal Challenge with Histamine, Bradykinin and Prostaglandin on Middle Ear Pressure and Blood Flow in Cynomolgus Monkeys

Preyious studies documented a significant increase in middle Car pressure following intranasal challenges with asCaris antigen or histamine in sensitized cynomolgus monkeys. To confirm that effects and inyestigate the mechanism, 4 monkeys were intranasally challenged at separate sessions with histamine (1O mg). bradykinin (1, 10 mg) and prostaglandin D2 (PgD2. 0.5. 1.0 mg) and followed for 90 min. Before and after challenge, middle Car pressure, mucosal blood How. hCart rate, blood pressure, body temperature and the partial pressures of O2 and CO2 in the yenous blood were measured. The results showed that while bradykinin challenge had no effect on these measures. PgD2 proyoked increased middle Car pressure, and histamine resulted in a biphasic pattern of increasing pressures followed by decreasing pressures. The pattern of change in middle Car pressure after histamine challenge was explicable by a mechanism inyolying transmucosal gas exchange, while that for PgD2 was related to increased mucosal inflamma...
Excess Cost of Emergency Department Visits for Nonurgent Care

Abstract: After examining data for patients with selected conditions and statistically adjusting for patient, diagnosis, and treatment characteristics, this DataWatch finds that charges for emergen...
A wide tuning range (1 GHz-to-15 GHz) fractional-N all-digital PLL in 45nm SOI

An all static CMOS (45 nm SOI) all-digital fractional-N PLL has a wide tuning range (from 0.84 GHz to 13.3 GHz, at 1.0 V, 65degC) and supports a broad range of multiplication factors (up to 1,000x) and reference clock speeds (from 2 MHz to 1 GHz). At 125degC the period jitter of the 4.12 GHz clock (206 MHz reference) is 1.1 ps rms (11.4 ps pp) at 1.3 V (52.4 mW), and 2.2 ps rms, (22.7 ps pp) at 0.7 V (9.7 mW). The area of the PLL is 175 mum times 160 mum.
High-Power 2.2- $\mu$ m Diode Lasers With Metamorphic Arsenic-Free Heterostructures

Metamorphic virtual substrates with lattice constants 0.9% larger than those of GaSb were developed by solid-source molecular beam epitaxy. The mismatch between the parent GaSb and the virtual substrate was accommodated by a network of misfit dislocations formed in GaInSb buffer layers with linearly graded indium and gallium compositions. Arsenic-free laser heterostructures emitting at 2.2 μm at room temperature were grown on virtual substrates. The antimony was the only group V element used in growth. These novel diode lasers operate at room temperature and generate above 1.4 W of continuous-wave (CW) power.
Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S‐nitrosylation

The sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR2) has been proposed to be an end target of neuronal nitric oxide synthase (NOS1) signalling. The purpose of this study is to investigate the mechanism of NOS1 modulation of RyR2 activity and the corresponding effect on myocyte function. Myocytes were isolated from NOS1 knockout (NOS1−/−) and wild-type mice. NOS1−/− myocytes displayed a decreased fractional SR Ca2+ release, NOS1 knockout also led to reduced RyR2 S-nitrosylation levels. RyR2 channels from NOS1−/− hearts had decreased RyR2 open probability. Additionally, knockout of NOS1 led to a decrease in [3H]ryanodine binding, Ca2+ spark frequency (CaSpF) and a rightward shift in the SR Ca2+ leak/load relationship. Similar effects were observed with acute inhibition of NOS1. These data are indicative of decreased RyR2 activity in myocytes with NOS1 knockout or acute inhibition. Interestingly, the NO donor and nitrosylating agent SNAP reversed the depressed RyR2 open probability, the reduced CaSpF, and caused a leftward shift in the leak/load relationship in NOS1−/− myocytes. SNAP also normalized Ca2+ transient and cell shortening amplitudes and SR fractional release in myocytes with NOS1 knockout or acute inhibition. Furthermore, SNAP was able to normalize the RyR2 S-nitrosylation levels. These data suggest that NOS1 signalling increases RyR2 activity via S-nitrosylation, which contributes to the NOS1-induced positive inotropic effect. Thus, RyR2 is an important end target of NOS1.
On the local structure of time-optimal controls in R3

The paper deals with the time-optimal control of a system ?: x = f(x) + ug(x), |u| ? 1, x ? IR3, u ? IR where f and g are smooth vector fields. We consider the system near a point p where both triples (f(p), g(p), [f,g](p)) and (g(p),[f,g](p),[f,[f,g]](p)) are independent. We show that, for a generic system ?, p has a neighborhood U such that any time-optimal trajectory of ? lying in U is a concatenation of at most 6 bang or singular arcs.
Ingestible RFID bio-capsule tag design for medical monitoring

The use of electromagnetics in medicine has facilitated the design of advanced biological systems and has also helped evolve medical treatments and diagnostic procedures significantly [1]. Electromagnetics, in particular radio frequency identification (RFID), can become a major player in medicine and thus, in health care. Due to the non line-of sight operation, larger read range and ability to store more information, RFID tags serve as a possible replacement to bar codes. By implementing RFID technology in health care and medicine, the dream of continuous medical monitoring of patients, storage of patient statistics, medicine tracking, drug delivery control and efficient medical management can be realized. RFID wrist-bands have been successfully used to identify patients in hospitals. Implantable RFID chips [2] have been reported for storing information and tracking location.
Should All Patients Be Treated With Hypothermia Following Cardiac Arrest

Cardiac arrest is a common and lethal medical problem; each year more than half a million people in the United States and Canada suffer cardiac arrest treated by emergency medical personnel or in-hospital providers. Of those who survive to hospital admission or suffer in-hospital arrest, 40-60% die prior to discharge. Neurologic injury is the major source of morbidity and mortality after recovery of spontaneous circulation. Therapeutic options to prevent neurologic injury are limited, but recent randomized trials showed that moderate therapeutic hypothermia improves neurologic outcome in selected patients following cardiac arrest. Clear consensus statements recommend that unconscious adult patients with spontaneous circulation after out-of-hospital cardiac arrest should be cooled if the initial rhythm was ventricular fibrillation, and that therapeutic hypothermia should be considered for other patients (other rhythms or in-hospital arrest). However, the position that all patients should be cooled following cardiac arrest is probably too broad, given the lack of studies on patients with non-ventricular-fibrillation rhythms, in-hospital arrest, or non-cardiac causes of arrest. Further research is needed to determine the broadest application of moderate therapeutic hypothermia.
Has the commercialisation of medical research gone too far

Government policy has been complicit in the increasing role of commercial companies in research, which in turn have little incentive to share the benefits of research. As a result, huge swathes of medical research rely on commercialisation and related patent protection in order to thrive. There is a distinct lack of evidence that commercialisation has led to an improvement in public health, the claim of increased innovation simply does not have empirical support. Commercialisation has led to skewed benefits in favour of companies, whereby industry is using the public’s resource without adequately paying for it, this imbalance may be seen as a form of exploitation. In this paper I argue that the skewed relationship between commercial and public interest needs to be addressed in order to ensure we meet healthcare needs of our patients in the future and ensuring the healthcare remains affordable.
Application of New Low-power Video Monitoring Devices in Hydrological Telemetry System

Present a new low-power integrated wireless data and video monitoring devices in the paper.It consists of low-power ACS02400 RTU,3G wireless communication device,cameras,batteries and sensors,the device can linkage video transmission and sensor data by using reasonable power,communications control,and sensor acquisition strategy.It can trigger video streaming by the data which exceed the warning value.And introduce the working principle of the device and the advantage of the device at last.
Role of Radiation Therapy

Patients with pancreatic cancer present in one of three ways. They may be clearly resectable, not clearly resectable but without evidence of hepatic, peritoneal, or more distant dissemination, or with obvious disseminated disease. While the majority of patients do have metastatic disease (>50–60 %) and the minority with clearly resectable disease is small (10–20 %), the 30–40 % of patients who are not clearly metastatic and not clearly resectable provide special challenges and opportunities in management. In this last category, a number of factors have been recognized as important for prognostic and therapeutic decision making. These include the distinction between “borderline resectable” and more locally advanced presentations, clinical factors (performance status, anemia, weight loss), biologic factors (SMAD 4, TP53), and the impact on survival of achieving gross total resection when clinically appropriate and possible. In addition, technical advances in radiation oncology provide new opportunities for safely exploiting this expanding base of clinical and prognostic knowledge for patient benefit. These issues are reviewed with an eye toward helping the busy surgeon or medical oncologist optimize care and outcomes for their pancreatic cancer patients in this category.
The Immunologic Role of the Gastrointestinal Tract

The gastrointestinal tract is now being recognized as a major immunologic organ. Breakdown in gastrointestinal immune function may occur during critical illness and contribute to the development of multiple organ systems failure. For the nurse professional, this article reviews gastrointestinal immune function and the numerous advances in the field of “nutritional pharmacology” to support the immunocompromised, metabolically stressed patient.
The experience of the tacit in multi- and interdisciplinary collaboration

In exploring his concept of interactional expertise in the context of managers of big science projects, Collins identifies the development and deployment tacit knowledge as central, but acknowledges that sociologically, he cannot probe the concept further in developmental or pedagogical directions. In using the term tacit knowledge, Collins relies on the concept as articulated by Michael Polanyi. In coining the term, Polanyi acknowledges his reliance on Heidegger’s concept of being-in-the-world. This paper explores how Polanyi, and so Collins, fails to adequately ground the idea of the tacit in Heidegger’s hermeneutic phenomenology. In so doing, it employs a rereading of Being and Time to phenomenologically resituate the tacit. This resituating of the tacit allows us to go further than Collins in providing developmental and pedagogical approaches to the tacit in the context of the kind of interactional expertise that may be employed to enhance the effectiveness of collaborative, multi-and interdisciplinary teams like those found in team science and in professional settings like healthcare management. As illustrative, the paper provides an example of this resituated understanding of the tacit in the author’s work teaching in a multidisciplinary healthcare management program.
Methylphenidate in Treatment of ADHD and Comorbid Chronic Tic Disorder

The safety and efficacy of immediate-release methylphenidate (MPH-IR) for the treatment of attention deficit hyperactivity disorder (ADHD) in children (ages 6-12 years) with Tourette's syndrome (96%) or chronic motor tic disorder (4%) were evaluated at State University of New York, Stony Brook.
Abstract 1192: Glutamic acid and glutaminolysis mark aggressive tumorigenesis in head and neck squamous cell carcinoma

The purpose of this study was to identify markers of aggressive tumor behavior to inform processes underlying tumor aggressivity in head and neck squamous cell carcinoma (HNSCC). To this end, metabolomic profiling and validation of biomarkers of aggressive HNSCC tumorigenesis were assessed in HNSCC human specimens and cell lines. Using LG/GC-MS, we found that glutamic acid is one of the most highly differentially elevated metabolites in HNSCC specimens. In subsequent validation studies, where we incorporated metastatic tissues, glutamic acid was further verified as differentially elevated in metastatic tissues compared to primary HNSCC and normal adjacent tissues. In addition, significantly elevated expression levels of c-Myc and glutaminase, the enzyme that regulates glutamic acid levels, were highest in metastatic tissues compared to primary HNSCC and normal tissues. Parallel changes in c-Myc and glutaminase expression in HNSCC tissues suggest a link between c-Myc regulation and glutamine metabolism. Furthermore, Western Blot analyses show similar expression patterns for c-Myc and glutaminase in oral cancer cell lines. Inhibiting glutamic acid levels by stably suppressing glutaminase expression in HNSCC cells, led to suppression of aggressive tumorigenesis in vitro, whereas enrichment with external glutamine or glutamic acid further enhanced tumorigenesis. Together, this data suggest that oncogenic levels of c-Myc may induce a transcriptional program that promotes elevated levels of glutamic acid and glutaminolysis via glutaminase to promote tumor aggressivity in head and neck cancer. Citation Format: Adam D. Banda, Mercedes Bermudez Cortes, Pachiyappan Kamarajan, Thekkenlnaycke Rajendiran, Arul M. Chinnaiyan, Yvonne L. Kapila. Glutamic acid and glutaminolysis mark aggressive tumorigenesis in head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1192. doi:10.1158/1538-7445.AM2015-1192
Radiotherapy for Meningioma

Meningioma is a relatively common primary intracranial tumor arising from the meninges. This tumor represents approximately 20% of all intracranialneoplasms (Prados et al. 1998; Mahaley et al. 1989; Walker et al. 1985; Laws and Thapar 1993). It is of interest to note that this incidence was nearly twice as high in the state of Minnesota (Walker et al. 1985). The reason for this higher incidence of meningioma in this state was not immediately apparent. Peak incidence of meningioma is 55 years of age, although this tumor has been reported at any age, including its uncommon incidence in children. Meningioma occurs primarily in women, with a reported female to male ratio of 2–3:1 (Prados et al. 1998; Laws and Thapar 1993). Over the past 20 years a substantial body of evidence has been accumulating about the hormonal influence on tumor growth, with particular reference to increased tumor growth rate during pregnancy (Lesch et al. 1987; Schrell and Fahlbusch 1991). It is also to be noted that this tumor is more common in those with breast cancer (Rubinstein et al. 1989), and there is good evidence for the presence of progesterone and estrogen receptors in meningioma cells (Lesch et al. 1987; Schrell and Fahlbusch 1991; Rubinstein et al. 1989).
Scalable multichannel joint sequential change detection and isolation

The problem of joint sequential change detection and isolation in a multichannel system is considered. It is assumed that a disruption occurs at some unknown time, and changes the distributions of the observations in an unknown subset of channels. The problem is to quickly detect the change, and at the same time to reliably isolate the affected channels. A novel scheme is proposed for this task, which admits a recursive structure, is scalable with respect to the number of channels, and does not require any prior information about the change-point. Its performance is analyzed in the special case that the number of affected channels is known. Specifically, explicit critical values are obtained for the control of the false alarm rate and the conditional probability of wrong isolation below arbitrary levels to be prescribed by the practitioner. Finally, the asymptotic optimality of the average detection delay of the proposed scheme is established as the error probabilities go to 0 and the effect of the prior distribution for the change point vanishes in the limit.
Real-time Activity-sensitive Wearable Ankle Edema Monitoring System For Elderly and Visually Impaired Heart Failure Patients

Heart failure (HF) is a leading cause of hospital admissions and readmissions, and carries significant morbidity and mortality in the elderly patient population. Worsening ankle edema is an early sign of an acute HF exacerbation and needs to be carefully monitored. We present the AnkleBracelet, a prototype of a real-time, activity-sensitive, wearable assistive device for monitoring ankle edema specifically designed for elderly, blind, and visually impaired patients. This device provides unobtrusive data regarding changes in ankle edema to encourage behavioral change through multimodal feedback and interaction. Data can be transmitted remotely to maintain a constant connection between physicians and their patients. This device has a patient-centered design that is evidence-based and was derived from a series of collaborations with cardiologists at Rush University Medical Center.
Fear of cancer recurrence and associations with mental health status and individual characteristics among cancer survivors: Findings from a nationally representative sample.

147Background: Fear of cancer recurrence (FCR) and related constructs are experienced by many cancer survivors and are consistently identified as important areas of need. This study adds to sparse ...
Modeling consumers’ intention to use fashion and beauty subscription-based online services (SOS)

This study examined one of the new consumption styles of modern consumers, subscription-based online services (SOS), which is often called as box retailing. The purpose of this study was to empirically test six antecedents—utilitarian motivations, hedonic motivations, fashion consciousness, consumer innovativeness, desire for unique products, and online transaction self-efficacy—as predictors of consumers’ attitude toward and intention to use fashion/beauty SOS. The theory of reasoned action was used as a theoretical foundation. With responses from 385 American consumers on an online survey, the theoretical model was tested in the fashion/beauty SOS context using structural equation modeling on LISREL. Results indicated that utilitarian and hedonic motivations, fashion consciousness, and online transaction self-efficacy indirectly influence intention to use fashion/beauty SOS, mediated by attitude towards fashion/beauty SOS. Instead of being mediated by attitude towards fashion/beauty SOS, consumer innovativeness and desire for unique products directly influence intention to use fashion/beauty SOS. Subjective norm positively influences intention to use fashion/beauty SOS. By identifying the factors that can predict consumers’ attitude towards and intention to use this new type of fashion/beauty consumption, this study addresses an evolving trend in home-based shopping behavior. Theoretically, as one of the earliest studies in this phenomenon, this study lays the theoretical groundwork paving way for further exploration in this area. Managers of fashion and beauty SOSs also can utilize these findings to more accurately target the appropriate consumer segment and streamline their marketing messages in accordance.
Supraventricular and Ventricular Arrhythmias

Atrial tachyarrhythmias are the most common arrhythmias occurring in ICU patients, with a reported prevalence of 28%. Atrial fibrillation (AF) is the most common atrial arrhythmia (52%) followed by atrial flutter (27%) and multifocal atrial tachycardia (MAT). Since the etiology and management strategies of atrial fibrillation and atrial flutter overlap, for the purposes of this discussion, they will be considered one entity, AF. Patients who develop AF have a worse prognosis than those who remain in sinus rhythm (SR); however, the attributable mortality of AF is unclear. Loss of atrioventricular synchrony will compromise stroke volume and cardiac output to a variable degree, depending upon ventricular compliance, venous filling pressure, ventricular rate, and other hemodynamic factors.
Proteins Involved in ARS Function in Yeast

Replication of eukaryote chromosomes requires the coodinated initiation of DNA synthesis at multiple replication origins on the chromosomes. These initiation events are under cell cycle and developmental regulation that is evident in a number of well-defined biological contexts. DNA synthesis is confined within S phase of the cell cycle. During S phase, each replication origin is activated no more than once in a specified temporal order (Reynolds et al., 1989; Ferguson et al., 1991). In embryonic and somatic cells, the contrasted number of replication origins utilized reflects the demand of a replication deadline imposed by the length of the S phase in a cell division cycle (Blumenthal, et al., 1973). Thus, one may expect individual replication origins to be differentially regulated according to the cell cycle or developmental program. We are interested in finding out how differential regulation is achieved in the initiation of DNA synthesis at multiple replication origins in yeast.
Immunotherapy of Uveitis: is Gene Therapy in our Future?

Gene therapy is a very attractive therapeutic option, as it carries the promise of more or less permanently curing a clinical condition. As our understanding of the critical checkpoints in the pathogenesis of autoimmune ocular disease improves, more and more potential intervention points and candidate therapeutic targets are identified. New technologies emerge, promising more specific and more easily applied therapies. Nevertheless, serious concerns about vector development and delivery methods remain to be addressed, including such issues as vector immunogenicity, method of administration, effi- ciency of transduction, duration of gene expression as well as the ability to turn expression off when deemed necessary. None of the therapy paradigms offers a perfect solution. In the case of antigen-specific therapies, arguably the most desirable approach, choice of antigen(s) is a central issue, as in many cases the participating antigen is uncertain and multiple specificities may be involved. Not to be ignored is also the potential for eliciting unwanted immune responses by the introduction of an autoantigen into an already primed host. Paradigms targeting common lymphocyte activation functions have the potential of inhibiting desired immune responses as well, whereas strictly local therapies, while having the potential for the fewest side effects, leave the underlying autoimmune process unaffected.
Philosophy and the Social Sciences

Can philosophy make fundamental substantive contributions to the social sciences? In this paper I argue that it can, on two counts., My focus is on the social scientific study of human beings.1
Generalized Memory-Assisted Adaptive-Threshold Detection Scheme for On-OFF-Keying Diffusion-Based Molecular Communications

This paper proposes a Generalized Memory-Assisted Adaptive-Threshold (G-MAAT) detection scheme for diffusion-based Molecular Communication (MC) systems. The proposed scheme applies to MC systems in which a single-type of molecules is assumed to carry the information from the single transmitting nanomachine (Tx Bio-NM), through a fluid medium, to the single receiving nanomachine (Rx Bio-NM). Thus, the information is represented by the received concentration of the information molecules, where the communication takes place in a three-dimensional diffusion-based unbounded environment. We present the generalized model of adaptive-threshold detection algorithm with N-Memory depth suitable for binary On-OFF Keying (BOOK signaling), where the Rx Bio-NM adapts the 1/0 bit detection threshold based on past received bits. This adjustment of the 1/0 detection threshold based on past received bits helps to alleviate the inter-symbol interference resulting from residual (tail) diffusion molecules arriving at the receiver due to past bit transmissions and reception noise. Furthermore, the complexity of G-MAAT is calculated and the performance evaluation in various noisy channel sources shows a promising improvement in the un-coded Bit Error Rate (BER) performance of the proposed scheme compared with other threshold detection mechanisms, which considerably more complex approaches found in the literature.
Relationships between Asymmetry of Cerebral Amyloid Deposition and Cognitive Performance in Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) (P06.032)

OBJECTIVE: To examine asymmetry of cerebral amyloid deposition in MCI and AD and relationships with cognitive deficits. BACKGROUND: The amyloid cascade hypothesis has been studied via in vivo amyloid Beta protein (AB) imaging, allowing for the examination of links between amyloid deposition and clinical aspects of AD. Relationships of lateral asymmetries of β-amyloid deposition with cognitive deficits have not been widely studied. Correlations following expected localizations would provide support for the amyloid cascade hypothesis. DESIGN/METHODS: Data from a subset of 103 participants from the Alzheimer9s Disease Neuroimaging Initiative (ADNI) who had amyloid imaging with Pittsburgh compound B were included in the current study (19 healthy controls, 62 MCI, 21 AD). Amyloid density was examined in 8 regions of interest: left frontal, right frontal, left temporal, right temporal, left parietal, right parietal, left cingulate, and right cingulate. Density in these regions was examined for (1) lateral asymmetries, and (2) links with cognitive functioning using the ADNI Neuropsychological Test Battery. RESULTS: Findings indicated relatively greater asymmetry in the temporal lobes than other brain regions, which did not differ by MCI or AD status. Greater amyloid deposition in the left frontal region was associated with poorer performance on Trails A (p CONCLUSIONS: The lack of strong interactions of asymmetry with cognitive function is in keeping with other evidence that AB deposition is not the primary element in provoking cerebral dysfunction in MCI and AD. Disclosure: Dr. Phillips has nothing to disclose. Dr. Mast has nothing to disclose. Dr. Ziegler has nothing to disclose. Dr. Hornhung has nothing to disclose. Dr. Friedland has nothing to disclose.
Bulk gold catalyzes hydride transfer in the Cannizzaro and related reactions

Bulk gold was found to catalyze the Cannizzaro reaction of benzaldehyde and related disproportionation reactions in superheated water. At 200 °C and 1.5 MPa for ∼48 hours, benzaldehyde conversions increased linearly with added gold at low loadings, but this trend reversed at higher gold loadings. Ratios of the primary products benzoic acid and benzyl alcohol exceeded unity, increasing with increasing amounts of gold. These observations are attributed to the reactivity of benzyl alcohol in the presence of gold, which is proposed to react via cross-disproportionation with benzaldehyde to yield toluene and benzoic acid, transitioning to benzyl alcohol disproportionation that forms toluene and reforms benzaldehyde at higher gold loadings. Turnover frequencies for both benzaldehyde (0.00013 s−1) and benzyl alcohol (0.0011 s−1) were quite low and experiments of varied duration demonstrated that very few turnovers occurred under the reaction conditions. Proposed mechanisms for the catalyzed reactions include hydride transfer from gold-bonded alkoxides to surface gold atoms. These observations expand the known catalytic capabilities of bulk gold to include hydride transfer, a fundamental process in organic chemistry and biochemistry. The simple, environmentally benign reaction conditions are reminiscent of organic geochemical processes, with implications for both geomimicry and green chemistry approaches to chemical challenges.
Meta-analysis and systematic review of intermediate-term follow-up of prostatic urethral lift for benign prostatic hyperplasia

Prostatic urethral lift (PUL), is a relatively new minimally invasive procedure for treatment of benign prostatic hyperplasia (BPH).This article is a systematic review and meta-analysis of all the articles published including follow-up of at least 24 months to analyze sustainability of results. We performed a critical review in according to the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. From a total 768 published articles that matched our search terms, 5 studies with minimum follow-up of 24 months were selected for comparison and data analyzed in terms of baseline characteristics, functional, and sexual health outcomes. Included in the analyses are five studies with a minimum follow-up of 24 months. A total of 386 patients underwent PUL and 322 patients (83.4%) are available for follow-up at 24 months. The randomized studies are grouped as group A and non-randomized studies as group B. At 24 months, the mean reduction in International Prostate Symptom Score (IPSS) from baseline was 9.1 in group A and 10.4 in group B. The mean improvement in peak flow rate (Qmax) was 3.7 mL/s in group A and 3 mL/s in group B, and quality of life (QoL) improved by 2.2 in both groups. PUL is a well-tolerated, minimally invasive therapy for BPH that provides favorable and durable symptomatic, sexual health, and functional outcomes up to 24 months. Longer follow-up and randomized studies comparing to current standards are required to further confirm the long-term sustainability of PUL.
Not Just Surviving, But Thriving: Overcoming Barriers to Career Advancement for Women Junior Faculty Clinician-Researchers.

Although women attend medical school and residency at similar rates to men, they experience lower levels of academic career advancement than men. To inform national gender equity efforts, the authors conducted a qualitative study to explore potential gender differences in the career experiences of junior research faculty at a premier research institution. Focus group discussions were conducted among women and men junior research faculty at the School of Medicine at an urban public research university. Participants were early mentored career development award recipients (K-awardees). Two same-gender focus groups of nine women and six men were conducted. Discussions focused on two domains: barriers to maintaining a research career and facilitators for research career development. Data were analyzed using ATLAS.ti and content analysis methods. Both women and men identified a challenging funding environment, difficulty bridging the salary gap, and lack of institutional support as barriers to maintaining their research careers. Women perceived two primary barriers to their career advancement that were different from their male counterparts: They were more likely to feel undervalued at the institution and to experience significant strains related to both childbearing and childcare. Women also reported receiving inadequate mentorship, having poor negotiation skills, and experiencing a lack of negotiation opportunities. Academic research institutions should consider interventions that provide financial, emotional, and practical support to women research faculty, particularly during their childbearing and childrearing years.
The utility of thrombophilia and hematologic screening in live liver donation.

BACKGROUND Most centers perform some degree of hematologic screening, including thrombophilia testing, on prospective live liver donors. The nature and extent of such screens are not standardized, and there is limited evidence regarding hematologic risk stratification. METHODS AND RESULTS We present an experience of hematologic screening among prospective liver donors. Five-hundred-eightyfour patients were screened for liver donation between 1/2013 and 1/2020, of whom 156 (27%) proceeded to donor hepatectomy. Thirty-three of 428 (8%) declined patients were excluded for hematologic indications. Hematologic indications were the 2nd most frequent medical indications for exclusion (trailing only hepatologic indications). The most common reason for hematologic exclusion was concern regarding thrombophilia. Nevertheless, 21 patients with evidence of possible thrombophilia proceeded to donor hepatectomy, and none incurred hematologic complications. Similarly, seven patients with screening findings concerning for increased bleeding risk (most often thrombocytopenia) underwent donor hepatectomy without hematologic complication. Three of 156 (2%) of patients who underwent donor hepatectomy incurred a hematologic complication (all thrombotic, none fatal). None of these patients had any evident hematologic risk factor on screening. CONCLUSION This study underscores the difficulty of hematologic risk stratification among prospective living donors, however, suggests that some patients with relatively mild risk factors may be safe for donation.
Developing novel heterogenous microstructures to balance between strength and ductility without restoration processes in commercial Al alloys

The mechanical response of polycrystalline materials significantly depends on the details of the microstructure. For example, different spatial grain size distributions can lead to different mechan...
Emotional Impact on Learning

A growing number of schools and districts have incorporated Social Emotional Learning (SEL) in their strategic plans, professional learning, and budgets. We are doing exploratory research in SEL to identify methods of assessing a studentâs emotional state in undergraduate courses; analyzing emotional state data to determine whether there is a correlation to performance; and helping the student recognize how their emotional state may be impacting performance.The experiment was conducted in one of the undergraduate courses in the Engineering School in Spring 2018. The course is offered every semester in multiple sections and has a total enrollment of approximately 650 students per year. One of the assignments in the course is a practice test that students complete before the midterm and the final exams. The practice test includes multiple-choice and true-false questions and can be retaken an unlimited number of times. Before each attempt students were asked to answer two questions as follows: How you feel about doing the test today? How intense is your feeling?We used a simple scale to determine the emotional valence (positive, neutral, negative) and a five point likert scale about the intensity of the emotion of the student before taking the test. We are currently analyzing the results to see if there is a correlation between the emotional valence and intensity of the emotion, and test performance. We would provide a summary of our findings along with recommendations on how to help students find a workaround for their emotional issues. CONTEXT: Social Emotional Learning (SEL) is the process through which children and adults acquire and effectively apply the knowledge, attitudes and skills necessary to understand and manage emotions, set and achieve positive goals, feel and show empathy for others, establish and maintain positive relationships, and make responsible decisions.We are doing exploratory research in SEL to identify methods of assessing a studentâs emotional state while performing course assignments and analyzing emotional state data to determine whether there is a correlation to performance.KEY TAKE-AWAYS: Some key takeaways are a simple method to assess emotions in a real world educational setting, that can be used to help students recognize their emotion, and also recognize whether their emotion may be impacting their performance on a given assignment. If there is a correlation, the students can be assisted to find a workaround for their emotional issue, such as getting additional counseling by a teacher, tutor, or psychologist to address the concern; or getting assistance in learning the material using different approaches that are adapted to his or her needs, such as flex time for test taking, or additional reassurance with shorter, easier assignments that gradually build up the studentâs confidence to tackle more complex material .