cssi/SciSciGPT-SciSciNet huggingface dataset:
Extended Koopmans' theorem ionization potentials for beryllium atom shake‐up transitions

The ionization potentials were calculated for Be using the extended Koopmans' theorem (EKT) using several full configuration interaction (CI) and multiconfigurational-self-consistent-field (MCSCF) wave functions as reference wave functions. The wave functions used account for 89.7–96.7% of the correlation energy. Comparisons are made with experimental values and with δCI values calculated as the difference in energy obtained from CI wave functions for Be and Be+. The best EKT IP differed from the δCI value by 0.0003 eV for the lowest IP and by 0.0006 eV for ionization into the lowest 2P state of Be+. A calculation of ionization into the second 2P state of Be+ requires diffuse orbitals that are unimportant in the wave function for the ground state of Be. This results in small natural orbital occupation numbers for natural orbitals needed in the EKT calculation. © 1994 John Wiley & Sons, Inc.
Epidermoid cyst of spleen, an unusual cause of massive splenomegaly

Abstract Spelenomegaly in a child can present a difficult diagnostic problem. Portal hypertension, leukemia, infection, lipidosis, and lymphoma are the most frequent causes. 1 Epithelial cysts are rare; they compose approximately 10% of the nonparasitic benign cysts of the spleen. 2 The diagnosis seldom is confirmed preoperatively. Percutaneous aspiration of the cyst and selective abdominal angiography are reported to be of major diagnostic value. 3.9 In one case to be reported, splenic aspiration prior to splenoportography lead to the presumptive preoperative diagnosis.
Radioactivity in Juvenile Columbia River Salmon: A Model to Distinguish Differences in Movement and Feeding Habits

Abstract The 32P specific activities and 65Zn concentrations were measured in juvenile salmon collected from the Columbia River during winter and spring of 1969. An environmental uptake study involving marked juvenile chinook salmon indicated that 32P specific activity values reach a maximum sooner than values for 65Zn concentration. The uptake study also suggested a short lag period before hatchery fish released to the Columbia River began rapid uptake of 32P and 65Zn. A graphical model based on 32P specific activities and 65 Zn concentrations was constructed which allows fish to be classified and differentiated with regard to their past feeding or movement behavior. Use of the model indicated that some hatchery fish released to the river either had feeding behavior unlike other hatchery fish or were not in the Columbia River the entire time from release until collection. Application of the model to a sample of 24 unmarked juvenile salmon collected from the Columbia River revealed several different group...
Comparison of flow-mediated dilatation of the brachial artery in coronary patients with low-density lipoprotein cholesterol levels <80 mg/dl versus patients with levels 80 to 100 mg/dl

Testing of peripheral vascular endothelial function was performed in subjects who had coronary artery disease and a low-density lipoprotein (LDL) cholesterol level
The rate of methanol production on a copper-zinc oxide catalyst: The dependence on the feed composition

Abstract The initial rates of formation of methanol over a copper-zinc oxide catalyst were measured in a batch reactor at 195 to 225 °C and 17 atm pressure. The measurements were made in the absence of mass and heat transport influence. The rates were found to increase with increasing CO 2 CO ratio in the feed, and were suppressed by the presence of water. The differences between these observations and those in previous work were discussed.
Survival yield comparison between ESI and SAII: Mechanistic implications

Abstract The survival yield (SY) method is commonly used in mass spectrometry to determine the energy deposited into ions by an ionization process. SY is the fraction of intact molecular ions that remain after fragmentation. In this study, we compared the fragmentation of three different thermometer ions as a function of various inlet voltages on an Orbitrap Exactive mass spectrometer using solvent assisted ionization inlet (SAII), electrospray ionization (ESI), and electrospray ionization inlet (ESII). The data shows that under the same inlet conditions SAII, which does not use a voltage, produces less fragmentation than either ESI or ESII, methods that use a voltage to initiate ionization. However, in the Orbitrap Exactive, fragmentation is more significantly related to the energy imparted to the ions during transition from the ionization region to the mass analyzer than to the ionization process. By minimizing the energy acquired during ion transfer to the mass analyzer, fragmentation is significantly decreased for the thermometer ions using any of the ionization methods. These results demonstrate that the ionization processes are insufficiently energetic to provide the necessary energy of activation for fragmentation of the thermometer ions studied here. By using voltages in the intermediate pressure region after the inlet tube to add energy to the ions during the transfer to the mass analyzer, differences in the SY are observed between ESI and SAII. The mechanistic implications relative to SAII and ESII are discussed along with comparisons with matrix assisted ionization inlet using the solid matrix 3-nitrobenzonitrile.
N-Terminal Truncated Cardiac TnI Extends Frank-Starling Response of the Heart

Cardiac TnI (cTnI) has an N-terminal extension containing two protein kinase A (PKA) phosphorylation sites, Ser23/24, and its removal by restrictive proteolysis in cardiac adaptation improves myocardial relaxation. Through transgenic expression of the N-terminal truncated cTnI (cTnI-ND) in the heart of endogenous cTnI knockout mice, we studied the function of cardiac muscle containing only cTnI-ND. The pure cTnI-ND hearts showed no hypertrophy or dilation with normal baseline function as compared to wild type controls (WT), confirming the non-destructive nature of cTnI-ND. Echocardiography found increased left ventricular end diastolic dimension in cTnI-ND hearts as compared to WT, implying increased relaxation and compliance in vivo. A series of preloads was tested in ex vivo working hearts for the effects of cTnI-ND on Frank-Starling response. cTnI-ND hearts showed responses to 5-10 mmHg preloads similar to that of WT. When preload was increased from 10 to 20 mmHg, cTnI-ND hearts exhibited better maintained left ventricular relaxation velocity, lower left ventricular end diastolic pressure and larger stroke volume responses than that of WT hearts. 10 nM isoproterenol further increased the positive effects of cTnI-ND on the responses of cardiac function to preloads, indicating that cTnI-ND enhances Frank-Starling relationship in the absence of direct effect of PKA phosphorylation at Ser23/24. Slack sarcomere length in isolated cardiomyocytes and the optimal sarcomere length for maximum tension development in intact left ventricular papillary muscle from cTnI-ND mice were similar to that of WT, suggesting that cTnI-ND extends the range of Frank-Starling response to high preloads by enhancing contractility independent of further increases in sarcomere length. The results demonstrated that the removal of cTnI N-terminal extension by restrictive proteolysis provides a novel posttranslational modification to utilize Frank-Starling mechanism in cardiac adaptation to physiological and pathological stresses.
Culture and the evolution of human cooperation

The scale of human cooperation is an evolutionary puzzle. All of the available evidence suggests that the societies of our Pliocene ancestors were like those of other social primates, and this means that human psychology has changed in ways that support larger, more cooperative societies that characterize modern humans. In this paper, we argue that cultural adaptation is a key factor in these changes. Over the last million years or so, people evolved the ability to learn from each other, creating the possibility of cumulative, cultural evolution. Rapid cultural adaptation also leads to persistent differences between local social groups, and then competition between groups leads to the spread of behaviours that enhance their competitive ability. Then, in such culturally evolved cooperative social environments, natural selection within groups favoured genes that gave rise to new, more pro-social motives. Moral systems enforced by systems of sanctions and rewards increased the reproductive success of individuals who functioned well in such environments, and this in turn led to the evolution of other regarding motives like empathy and social emotions like shame.
REX: secure, extensible remote execution

The ubiquitous SSH package has demonstrated the importance of secure remote login and execution. As remote execution tools grow in popularity, users require new features and extensions, which are difficult to add to existing systems. REX is a remote execution utility with a novel architecture specifically designed for extensibility as well as security and transparent connection persistence in the face of network complexities such as NAT and dynamic IP addresses. To achieve extensibility, REX bases much of its functionality on a single new abstraction--emulated file descriptor passing across machines. This abstraction is powerful enough for users to extend REX's functionality in many ways without changing the core software or protocol. REX addresses security in two ways. First, the implementation internally leverages file descriptor passing to split the server into several smaller programs, reducing both privileged and remotely exploitable code. Second, REX selectively delegates authority to processes running on remote machines that need to access other resources. The delegation mechanism lets users incrementally construct trust policies for remote machines. Finally, REX provides mechanisms for accessing servers without globally routable IP addresses, and for resuming sessions when a TCP connection aborts or an endpoint's IP address changes. Measurements of the system demonstrate that REX's architecture does not come at the cost of performance.
Is Precedence a Secondary Quality? A Reply to Robin Le Poidevin

Le Poidevin’s argument is that defenders of the tenseless theory of time must explain the aspects of our experience of time that seem to suggest that the tensed theory of time is true. In particular, he mentions (1) what is experienced is always experienced at present; (2) we seem to share the same present and (3) we perceive that one thing occurs after another. Regarding the third point, we perceive something y as occurring after something x because in part our perception of y is causally influenced by our perception of x.
A Process for Development and Validation of a Customized Scale to Assess Work Environment in Government Organizations: A Mixed Method Approach

This study developed and tested a survey instrument to evaluate work environment in a government organization. A three-phase process, using both qualitative and quantitative methods, is presented f...
Betwixt Safety and Shielding in the Academy: Confronting Institutional Gendered Racism-Again

This article represents a critical reflection of a Black African American female associate professor who, while teaching a diversity course, unknowingly enabled systems of power and privilege to undermine her faculty role in the course and in the academy. The author revisits a story of this experience and its vestiges using Critical Race Theory (CRT) and an autoethnographic approach. In doing so, she comes to terms with her complicity in supporting White supremacy and patriarchy and reclaims a voice previously suppressed yet still vulnerable in the matrix of institutional power. Two significant shifts are captured in this account--a narrative shift from the individual to one that includes the institutional and a political shift from a position of naivete to critical consciousness. These shifts, illustrated by the metaphor of safety, reflect the dissonance experienced by the author in seeking to negotiate a balance between the personal, professional, and socialized traditions of academia.
Geomagnetic polarity epochs: age and duration of the olduvai normal polarity event

Abstract New data show that the Olduvai normal geomagnetic polarity event is represented in Olduvai Gorge, Tanzania, by rocks covering a time span of roughly from 0.1 to 0.2 my and is no older than 2.0 my. Hence the long normal polarity event of this age that is seen in deep-sea sediment cores and in magnetic profiles over oceanic ridges should be called the Olduvai event. The lava from which the Gilsaevent was defined may have been erupted during the Olduvai event and, if so, the term Gilsashould now be abandoned. Many dated lavas that were originally assigned to the Olduvai event represent one or two much shorter normal polarity events that preceded the Olduvai event; these are herein named the Reunion normal polarity events. This revision brings the geomagnetic reversal time scale into conformity with the one implied by assumptions of uniform sedimentation rates on the ocean floor and uniform rates of sea-floor spreading.
Arabidopsis plants harbouring a mutation in AtSUC2, encoding the predominant sucrose/proton symporter necessary for efficient phloem transport, are able to complete their life cycle and produce viable seed.

Background and aims AtSUC2 encodes a sucrose/proton symporter that localizes throughout the collection and transport phloem and is necessary for efficient transport of sucrose from source to sink tissues in Arabidopsis thaliana. Plants harbouring homozygous AtSUC2 null alleles accumulate sugar, starch, and anthocyanin in mature leaves, have severely delayed development and stunted growth and, in previous studies, failed to complete their life cycle by producing viable seed. Methods An AtSUC2 allele with a T-DNA insertion in the second intron was analysed. Full-length transcript from this allele is not produced, and a truncated protein translated from sequences upstream of the insertion site did not catalyse sucrose uptake into yeast, supporting the contention that this is a null allele. Mutant plants were grown in a growth chamber with a diurnal light/dark cycle, and growth patterns recorded. Key results This allele (SALK_038124, designated AtSUC2-4) has the hallmarks of previously described null alleles but, despite compromised carbon partitioning and growth, produces viable seeds. The onset of flowering was chronologically delayed but occurred at the same point in the plastochron index as wild type. Conclusions AtSUC2 is important for phloem loading and is therefore fundamental to phloem transport and plant productivity, but plants can complete their life cycle and produce viable seed in its absence. Arabidopsis appears to have mechanisms for mobilizing reduced carbon from the phloem into developing seeds independent of AtSUC2.
Semantic priming modulates the N400, N300, and N400RP

Objective: To determine whether ERP components can differentiate between the semantic priming mechanisms of automatic spreading activation, expectancy, and semantic matching. Methods: The present study manipulated two factors known to differentiate semantic priming mechanisms: associations between words (forward, backward, and symmetrical) and prime-target stimulus onset asynchrony (SOA). Twenty-six participants were tested in each SOA condition while high-density 128-channel data were collected. Principal components analysis was applied to separate the ERP components. Results: Priming was observed for all conditions. Three semantic components were present: (1) the standard N400 effect for symmetric and forward priming pairs at both short and long SOAs, (2) an N300 for the long SOA symmetric priming pairs, and (3) a right-lateralized posterior N400RP for long SOA backward priming pairs. Conclusions: Results suggest that the N300 reflects expectancy, but only for categorical and/or semantic similarity priming. Results further suggest that the N400RP is a replicable ERP component that responds to semantic matching. There is also some evidence that the N400 indirectly responds to both ASA and expectancy, perhaps as part of a post-lexical updating process and that backward priming at short SOAs is different from that at long SOAs. Significance: Improved understanding of the semantic properties of the N400 and related ERP components may increase their utility for understanding language processes and for diagnostic purposes. � 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
A wirelessly powered system with charge recovery logic

In this paper, charge recovery logic is proposed as an alternative to traditional or near-threshold CMOS logic for high-performance systems where the power is wirelessly delivered, e.g. bio-implantable devices. This approach has two primary, complementary advantages in i) providing a wirelessly transmitted sine-wave as the power clock source to the charge recovery logic and ii) eliminating the AC/DC power stage required to provide a stable supply voltage needed in CMOS circuits. The paper presents solutions to the main obstacles of this method and shows simulation results of a simple logic load designed in Efficient Charge Recovery Logic (ECRL) as part of a wireless powered system. The designed wirelessly powered ECRL (coined WP-ECRL) system i) consumes 15.2 x less power than full-swing CMOS and ii) operates at higher frequencies than near-threshold CMOS. These comparative trends in power dissipation are for the computing circuit only, and do not include the bulky AC/DC stage that would be necessary for CMOS implementations. In terms of resilience, it is shown that logic functionality is preserved even when the coupling coefficient of the wireless link is decreased by 60% from the nominal value or when coils with very poor quality factor (down to Q = 0.1) are used.
Are BSW Students Prepared to Address Substance Abuse in Clients

Social work has a long history of working with clients with substance abuse issues, yet minimal attention has been given to academic preparation at the BSW level to work with this population. This study examines the competence of undergraduate social work students to successfully identify and respond to substance abuse issues in future clients. Perceived competence was examined in 50 senior BSW completed students at a midsize state university. Findings suggest that the undergraduate social work academic core curriculum does not adequately prepare future social workers to work with clients with substance abuse disorders. This study brings awareness to the academic arena for the need to have substance abuse content infused into the core social work curriculum to adequately prepare undergraduate social work students to feel confident and able to successfully identify, assess, and treat substance abuse issues in practice.
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential

Adult tissue stem cells (SCs) reside in niches, which orchestrate SC behavior. SCs are typically used sparingly and exist in quiescence unless activated for tissue growth. Whether parsimonious SC use is essential to conserve long-term tissue-regenerating potential during normal homeostasis remains poorly understood. Here, we examine this issue by conditionally ablating a key transcription factor Forkhead box C1 (FOXC1) expressed in hair follicle SCs (HFSCs). FOXC1-deficient HFSCs spend less time in quiescence, leading to markedly shortened resting periods between hair cycles. The enhanced hair cycling accelerates HFSC expenditure, and impacts hair regeneration in aging mice. Interestingly, although FOXC1-deficient HFs can still form a new bulge that houses HFSCs for the next hair cycle, the older bulge is left unanchored. As the new hair emerges, the entire old bulge, including its reserve HFSCs and SC-inhibitory inner cell layer, is lost. We trace this mechanism first, to a marked increase in cell cycle-associated transcripts upon Foxc1 ablation, and second, to a downstream reduction in E-cadherin–mediated inter-SC adhesion. Finally, we show that when the old bulge is lost with each hair cycle, overall levels of SC-inhibitory factors are reduced, further lowering the threshold for HFSC activity. Taken together, our findings suggest that HFSCs have restricted potential in vivo, which they conserve by coupling quiescence to adhesion-mediated niche maintenance, thereby achieving long-term tissue homeostasis.
Rethinking Art Education Practice One Choice at a Time

I knew it was time to rethink my teaching practice when my elementary students began rushing through their assigned projects to work on their own ideas at the “free draw” table at the back of the r...
Entrepreneurs Enacting Conflicting Organizational Identities to Gain Legitimacy

Using ethnographic and archival data within the context of “X- fit”—an emerging organization in a nascent extreme fitness market segment—this study seeks to understand how multiple organizational i...
Introduction to Microelectrode Arrays, the Site-Selective Functionalization of Electrode Surfaces, and the Real-Time Detection of Binding Events

Microelectrode arrays have great potential as analytical tools because currents can be independently measured at each electrode in the array. In principle, these currents can be monitored in order to follow in real time the binding events that occur between the members of a molecular library and a biological target. To capitalize on this potential, the surface of the array must be selectively functionalized so that each unique member of the molecular library is associated with a unique individually addressable electrode or set of electrodes in the array. To this end, this instructional review summarizes methods for coating the arrays with porous polymers that allow for the attachment of molecules to the surface of the array, selectively conducting reactions at individual electrodes in the array, characterizing molecules that are placed on the arrays, and running the analytical experiments needed to monitor in real time binding events between molecules on the array and a biological target.
The isolation and properties of the specific binding sites for Escherichia coli RNA polymerase on T4 and T7 bacteriophage DNAs

Abstract RNA polymerase of Escherichia coli was allowed to bind to labeled T4 or T7 bacteriophage DNA. The unbound and “weakly” bound polymerase molecules were removed by adding an excess of poly(I) which has a high affinity for the enzyme (Bautz et al. , 1972). After the unbound DNA regions were digested with pancreatic DNAase and snake venom phosphodiesterase, the “protected” DNA-RNA polymerase complexes were isolated by Sephadex G200 column chromatography. The protected DNA sites were then isolated by phenol extraction and hydroxylapatite chromatography. Studies of the DNA recognition regions led to the following conclusions. (1) No binding is observed in the absence of the sigma subunit or at low temperatures. (2) The amount of protection ranges from 0·18% to 0·24% of T4 DNA and from 0·25% to 0·34% of T7 DNA. In the absence of poly(I), higher protections are observed and the protected regions display heterogeneity in size and secondary structure. (3) The protected regions are double-stranded, as shown by hydroxylapatite chromatography, base composition analysis, and thermal chromatography. (4) The length of the protected regions comprise about 50 to 55 nucleotide pairs, as suggested by end-group analysis, sucrose density-gradient centrifugation, and polyacrylamide gel electrophoresis. (5) The results suggest the interaction of dimeric polymerase molecules at these sites. On the basis of DNA sizes, there are 7 to 9 such sites on T4 DNA and 2 to 3 on T7 DNA. (6) The protected regions are high in (A + T): 68% for T4 and 62% for T7 DNA. (7) Thermal chromatograms reflect these base compositions and suggest the homogeneity of these regions with respect to size and base composition.
Selective bromochlorination of a homoallylic alcohol for the total synthesis of (−)-anverene

The scope of a recently reported method for the catalytic enantioselective bromochlorination of allylic alcohols is expanded to include a specific homoallylic alcohol. Critical factors for optimization of this reaction are highlighted. The utility of the product bromochloride is demonstrated by the first total synthesis of an antibacterial polyhalogenated monoterpene, (-)-anverene.
A Quasineurological Model Elucidating the Causality of Freud's Topographic Formulation

Freud's topographic formulation is central to psychoanalytic theory. Nevertheless, there is little understanding of the causality underlying the topographic phenomena. This paper elaborates Hebb's theory, introducing more complex operations which are used as concrete explanation for the topographic formulation. A simplified six-step developmental outline of the unconscious process is employed to show how punishment may lead to fear and fear-avoidance, permanent anxiety and defense against anxiety, cognitive deficit and repression, and behavioral rigidification It becomes possible to see how the mental apparatus can give rise to the rational and irrational, how these two spheres of action may reside side by side and interpenetrate.
An ultra-wideband Vivaldi and linear hybrid taper antenna for use in a near-field real-time phased array radar system

A novel ultra-wideband (UWB) antenna element is developed for use in a near-field phased array radar system. This antenna uses a Vivaldi-style tapered slot implemented on a printed circuit board (PCB). It consists of feed, taper, and rolled-edge sections that produce a gradual transition for electromagnetic energy providing better than 2:1 VSWR over a 30:1 bandwidth from 800 MHz to 25 GHz. The radiation characteristics are optimized for high gain (10-15 dBi) from 2 to 4 GHz, exceeding the directivity of most Vivaldi tapered designs. This element is designed for operation in a near-field phased array radar imaging system that produces realtime radar imagery at the frame-rate of 10.8 Hz for use in through-wall or any other real-time imaging applications.
Missing Elements in the Discussion of Teacher Shortages.

Though policymakers are increasingly concerned about teacher shortages in U.S. public schools, the national discussion does not reflect historical patterns of the supply of and demand for newly minted teachers. Specifically, the production of teacher candidates has increased steadily since the mid-1980s, and only about half of graduating teacher candidates are hired as public school teachers in a typical year. That said, there is considerable evidence of teacher shortages in specific subjects (e.g., STEM and special education) and specific types of schools (e.g., disadvantaged). We therefore discuss public policies that contribute to these specific shortages and potential solutions.
Lateral Movement Detection Using Distributed Data Fusion

Attackers often attempt to move laterally from host to host, infecting them until an overall goal is achieved. One possible defense against this strategy is to detect such coordinated and sequential actions by fusing data from multiple sources. In this paper, we propose a framework for distributed data fusion that specifies the communication architecture and data transformation functions. Then, we use this framework to specify an approach for lateral movement detection that uses host-level process communication graphs to infer network connection causations. The connection causations are then aggregated into system-wide host-communication graphs that expose possible lateral movement in the system. In order to provide a balance between the resource usage and the robustness of the fusion architecture, we propose a multilevel fusion hierarchy that uses different clustering techniques. We evaluate the scalability of the hierarchical fusion scheme in terms of storage overhead, number of message updates sent, fairness of resource sharing among clusters, and quality of local graphs. Finally, we implement a host-level monitor prototype to collect connection causations, and evaluate its overhead. The results show that our approach provides an effective method to detect lateral movement between hosts, and can be implemented with acceptable overhead.
Herpes zoster keratitis development after acute retinal necrosis

To report a case of herpes zoster keratitis in a patient undergoing treatment for herpetic acute retinal necrosis. Case report. A 71 year old male presented with acute retinal necrosis of the left eye due to herpes zoster and was treated with intravitreal foscarnet and oral valcyclovir. He developed a retinal detachment and underwent surgical repair. After four weeks, he developed an ipsilateral herpetic zoster keratitis demonstrated by Rose-Bengal staining that was responsive to topical ganciclovir gel. This case report describes the unusual development of herpes zoster keratitis after the development of unilateral acute retinal necrosis (ARN) in a patient on antiviral treatment.
Geology Museum-Based Learning in Soil Science Education.

Museums provide unique learning opportunities in soil science. The Bob Campbell Geology Museum in Clemson, SC, features an exhibit of minerals and rocks common in the state and in its geologic history. We developed a hands-on laboratory exercise utilizing an exhibit that gives college students an opportunity to visualize regional minerals and rocks from which regional soil parent materials are derived. Clemson University students from various majors had a field trip and a hands-on experience with the local minerals and rocks during FNR 204: Soil Information Systems course taught in the fall 2008, summer 2011, and fall 2011 (134 students total). Students were then asked to fill out a survey providing answers to 15 questions related to their learning experience. Sixty-six percent of the students had never visited a Geology Museum before this field trip and 40% of the students did not know about the Geology Museum’s existence on campus. Ninety-three percent of the students thought the visit to the Geology Museum would be helpful with preparation for class quizzes and exams, and 92% of the students would recommend that their friends visit this museum in their free time. Overall, student responses to the questionnaire about their laboratory experience at the Geology Museum were positive. Laboratory exercises that are specifically designed to bridge university-level course material and museum collections produce learning synergy that is greater than either an independent museum visit or classroom instruction.
Cloud Security Automation Framework

Cloud services have gained tremendous attentionas a utility paradigm and have been deployed extensively across awide range of fields. However, Cloud security is not catching upto the fast adoption of its services and remains one of the biggestchallenges for Cloud Service Providers (CSPs) and Cloud ServiceConsumers (CSCs) from the industry, government, andacademia. These institutions are increasingly faced with threatssuch as DoS/DDoS attacks, ransomware attacks, and databreaches that are affecting the confidentiality, integrity, andavailability of the cloud system resources. In the current cloudsystems, security requires manual translation of securityrequirements into controls. Such an approach can be for themost part labor intensive, tedious, and error-prone leading toinevitable misconfigurations rendering the system-at-handvulnerable to misuse, either malicious or unintentional.Therefore, it is of utmost importance to automate theconfiguration of the cloud systems per the client’s securityrequirements steering clear from the caveats of the manualapproach. Furthermore, cloud systems need to be continuouslymonitored for any misconfigurations. This paper presents amethodology allowing for cloud security automation anddemonstrates how a cloud environment can be automaticallyconfigured to implement a set of NIST SP 800-53 securitycontrols. In addition, this paper shows how the implementationof these controls in the cloud systems can be continuouslymonitored and validated.
Is Cannabis Use Associated with Various Indices of Motivation among Adolescents

Decreased motivation is often noted as a consequence of cannabis use (CU). Previous work has yielded mixed findings, relied mostly on adult samples, and varied to the extent that it accounted for p...
Multi-color autofluorescence and scattering spectroscopy provides rapid assessment of kidney function following ischemic injury

A major source of kidneys for transplant comes from deceased donors whose tissues have suffered an unknown amount of warm ischemia prior to retrieval, with no quantitative means to assess function before transplant. Toward addressing this need, non-contact monitoring of optical signatures in rat kidneys was performed in vivo during ischemia and reperfusion. Kidney autofluorescence images were captured under ultraviolet illumination (355 nm, 325 nm, and 266 nm) in order to provide information on related metabolic and non-metabolic response. In addition, light scattering images under 355 nm, 325 nm, and 266 nm, 500 nm illumination were monitored to report on changes in kidney optical properties giving rise to the observed autofluorescence signals during these processes. During reperfusion, various signal ratios were generated from the recorded signals and then parametrized. Time-dependent parameters derived from the ratio of autofluorescence under 355 nm excitation to that under 266 nm excitation, as well as from 500 nm scattered signal, were found capable of discriminating dysfunctional kidneys from those that were functional (p < 0.01) within hours of reperfusion. Kidney dysfunction was confirmed by subsequent survival study and histology following autopsy up to a week later. Physiologic changes potentially giving rise to the observed signals, including those in cellular metabolism, vascular response, tissue microstructure, and microenvironment chemistry, are discussed.
Adolescents show differential dysfunctions related to Alcohol and Cannabis Use Disorder severity in emotion and executive attention neuro-circuitries

Alcohol and cannabis are two substances that are commonly abused by adolescents in the United States and which, when abused, are associated with negative medical and psychiatric outcomes across the lifespan. These negative psychiatric outcomes may reflect the detrimental impact of substance abuse on neural systems mediating emotion processing and executive attention. However, work indicative of this has mostly been conducted either in animal models or adults with Alcohol and/or Cannabis Use Disorder (AUD/CUD). Little work has been conducted in adolescent patients. In this study, we used the Affective Stroop task to examine the relationship in 82 adolescents between AUD and/or CUD symptom severity and the functional integrity of neural systems mediating emotional processing and executive attention. We found that AUD symptom severity was positively related to amygdala responsiveness to emotional stimuli and negatively related to responsiveness within regions implicated in executive attention and response control (i.e., dorsolateral prefrontal cortex, anterior cingulate cortex, precuneus) as a function of task performance. In contrast, CUD symptom severity was unrelated to amygdala responsiveness but positively related to responsiveness within regions including precuneus, posterior cingulate cortex, and inferior parietal lobule as a function of task performance. These data suggest differential impacts of alcohol and cannabis abuse on the adolescent brain.
Proteasomes and Other Nanocompartmentalized Proteases of Archaea

A growing number of proteases and peptidases have been identified that form large nanocompartmentalizedstructures in the cytosol, membrane, and extramembrane of cells. In archaea, these include the intracellularenergy-dependent proteasomes and the membrane-associated Lon protease as well as the intracellular energy-independenttetrahedral aminopeptidase (TET), tricorn peptidase (TRI), and PfpI-like proteases. Homologs of HtrA proteinsare also distributed in some archaea and may form nanocompartments that switch function from chaperone toprotease with increasing temperature. The location of these latter homologs remains to be determined.
Predicting length of stay after hip or knee replacement for rheumatoid arthritis.

Objective. To identify predictors of the postoperative length of stay (LOS) after hip or knee replacement for rheumatoid arthritis (RA). Methods. Demographic and clinical characteristics, medications, and postoperative course were abstracted from medical records of patients with RA who underwent total arthroplasties of the knee (TKA) or hip (THA) at our institution between 1987 and 1991. The relationship between these variables and the postoperative LOS was examined using life tables, linear regression. and multiple regression analyses. Results. During the 5 years of the study, 137 patients with RA underwent 119 TKA and 105 THA. The average LOS was 16.9 ± 8.7 days after THA and 19.5 ± 11.4 days after TKA (p = 0.08). Significantly longer LOS was associated with age ≥ 55 years, female sex, non-white ethnicity, poor functional status, known positive rheumatoid factor, use of bone cement, and operating room (OR) time longer than 6 hours. In a multivariate regression model, a preoperative Steinbrocker functional class 3 or 4 was associated with an increase in LOS of 3.98 days (95% confidence interval 0.78, 7.18) and 7.14 days (2.59, 11.69), respectively, while a known positive rheumatoid factor predicted an increase in LOS of 2.76 days (0.17, 5.35). Among operative factors, the use of bone cement was associated with a LOS that was longer by 3.50 days (0.80, 6.20), and each hour increase in OR time with a delay in discharge of 1.75 days (1.18, 2.33). Major postoperative wound complications increased LOS by 16.46 days (11.40,21.52). Conclusion. Preoperative functional status is an important determinant of the rate of recovery of functional independence after surgery. Strategies for decreasing LOS after hip or knee replacements include optimization of preoperative functional status, early surgical intervention, and prevention of wound complications.
Non-stationary hydropower generation projections constrained by environmental and electricity grid operations over the western United States

In the western United States, 27% of electricity demand is met by hydropower, so power system planners have a key interest in predicting hydropower availability under changing climate conditions. Large-scale projections of hydropower generation are often simplified based on regression relationships with runoff and they are not always ready to inform power system models due to the coarse time scale (annual) or limited number of represented power plants. We developed an enhanced process-based hydropower model to predict future hydropower generation by addressing the commonly under-represented constraints, including (1) the ecological spills, (2) penstock constraints to provide flexibility in electricity operations, and (3) biases in hydro-meteorological simulations. We evaluated the model over the western United States under two emission scenarios (RCP4.5 and RCP8.5) and ten downscaled global circulation models. At the annual time scale, potential hydropower generation is not projected to change substantially, except in California. At the seasonal time scale, systematic shifting of the generation patterns can be observed in snowmelt-dominated regions. These projected annual and regional trends are comparable to other regression-based relationships. However, the representation of more complex operations and constraints tend to reduce the uncertainties inherent to climate projections at seasonal scale. In the Pacific Northwest region where hydropower is the dominant electricity source, our predicted future change of hydropower generation is about 10% less than the regression-based projections in spring and summer. The model can also capture the seasonal non-stationary in hydrologic changes. The spatio and temporal scales of the model, increased accuracy and quantification of uncertainty allow one to use the products to inform power system models toward supporting energy sector planning activities and water-energy trade-offs.
The Voyage d’Entrecasteaux: Part 5 Tasmania Revisited

Once the reprovisioning and the repair of both frigates was underway, Entrecasteaux sent a party to inspect the area of their of their anchorage the previous year in North Port. Their former watering-station was found to be completely dry, and Delahaye’s garden had not suceeded. The General then asked Delahaye to visit the site to determine the cause of the failure. Had the garden been planted in the wrong season? or had the seeds not preserved their fertility? Labillardiere now had the exceptional opportunity to collect again plants already known to him but in a different season of their development, as well as to find species overlooked in 1792. When he went ashore on 22 January 1793, however, his most memorable initial find was a skillfully-built aboriginal hut, its covering of tree-bark so arranged that even the hardest rains could not penetrate. From all appearances, it was a shelter where natives came to sleep at night. The desire to observe the interior of the hut led several in the party to enter it. The vermin inside they picked up on their clothes soon began to sting them, an unpleasant first lesson in the facts of aboriginal life.
Leucine-rich Repeat Receptor-like Kinases in Plants

Plant leucine-rich repeat receptor-like kinases were identified from databases using computer programs. Sequence comparison indicated that consensus sequences of the leucine-rich repeat motifs are highly conserved among these proteins. Multiple alignment of the catalytic kinase domains of all sequences displayed an overall amino acid sequence similarity. A phylogenetic analysis indicated that leucine- rich repeat receptor-like kinases form four subgroups in plants.
Effect of Equation of States on High-Pressure Volumetric Measurements of Methane–Coal Sorption Isotherms—Part 1: Volumes of Free Space and Methane Adsorption Isotherms

High-pressure volumetric analysis (HPVA) experiments were carried out using Particulate System’s HPVA-II 200 at temperatures of 25 and 40 °C and pressures up to 7 MPa to quantify methane adsorption...
A fold strategy

It is generally difficult to know in advance if a sheet of paper can be folded into an origami shape, but for quadrilateral crease patterns a tiling approach can identify all possible ways of folding them.
Feeding in the rotifer Brachionus calyciflorus : I. Regulatory Mechanisms.

Feeding behavior in B. calyciflorus was observed in both constrained and unconfined individuals. There are at least three mechanisms by which the ingestion of suspended particles may be regulated. First, the cirri of the pseudotrochus may be extended, allowing particles to enter the funnel-shaped buccal field, or they may be bent over medially, forming a screen over the buccal field and preventing the entrance of even very small particles, such as yeast. Second, particles which do enter the buccal field may be rejected before being taken into the oral canal, presumably by a change in the ciliary beat. Third, particles accepted into the oral canal may be pushed back into the buccal field by the jaws and then rejected. The first two control mechanisms were observed to operate in unconfined rotifers attached to a surface or actively swimming through the medium, while the third mechanism was noted only at high magnification in constrained rotifers. B. calyciflorus employs different modes of feeding when in suspensions of the yeast Rhodotorula and in those of Euglena; pseudotrochal screening was seen only rarely in the former but communly in the latter.
International Effects of Stock Market Dispersion

We study the extent to which stock market dispersion is related to unemployment and output growth for 16 countries over 20 years. Using panel vector‐auto‐regressions and panel dynamic regressions, we find increases in stock market dispersion across industries to induce future increases in unemployment and future decreases in industrial production (IP) growth. Moreover, the responses of unemployment and IP growth following a positive shock to stock market dispersion are persistent and are robust to various controls, sample periods, and estimation methods. Our article provides cross‐country evidence in support of the hypothesis that shifts in demand across industries negatively affect employment.
OP85 The challenge of finding the ‘right’ outcome to measure the effects of ACP: Part III

Background A key outcome of successful advance care planning is consistency between patient goals of care and the care provided. However, assessing consistency is methodologically challenging due to conceptual and logistical barriers as well as practice limitations. Methods The team reviewed the literature and identified key methodological barriers to measuring care consistency with patient preferences and goals of care. Strategies to overcome these barriers are proposed. Results Key methodological barriers include: 1) the specificity and relevance of documentation about preferences and goals of care; 2) the availability of documentation about preferences and goals of care; 3) the stability of documented preferences and goals of care; 4) the timing of treatments provided and identifying decisions not to treat (“non- events”); and 5) calculating rates of consistency. Strategies to address these methodological barriers include using tools to document specific preferences, incorporation into electronic health records, period reassessment of preferences, prospective data collection, and using percent agreement to report consistency. Discussion There are clear challenges to assessing care consistency with preferences and goals of care. The ability to assess and report on this important outcome of successful advance care planning requires focused efforts to improve practice.
Exploring Mentoring Experiences, Perceptions, and Needs of General Internal Medicine Clinician Educators Navigating Academia: a Mixed-Methods Study

Few studies examined specific mentoring needs and preferences of clinician educators (CEs). Further research on CEs’ perceptions of mentoring adequacy, as related to educational development and career advancement, is needed. The study aims were to (1) explore general internal medicine CEs’ experiences as mentees within various mentoring models; (2) examine the perceived quality, nature, and impact of mentoring on career development; and (3) determine whether specific models of mentoring impact their attitudes towards mentoring. Sequential mixed methods study design answered the study questions. Society of General Internal Medicine members identifying themselves as CEs. Participants completed an anonymous online survey and a subsample participated in two semi-structured focus group discussions. Outcomes of interest were perceptions of mentoring experiences, and perspectives on quality of mentoring as well as mentoring needs specific to clinician educators. One hundred thirty-nine participants completed the survey (37% response rate) with 20 participants in focus group discussions. Among CEs with perceived high-quality mentor relationships (e.g., reporting strongly agree), peer mentorship was viewed as adequate mentorship (45% (n = 17) vs 24% (n = 24), p < 0.05), as beneficial for career development (77% (n = 40) vs 48% (n = 41), p < 0.01) and as being challenged to become a better CE (58% (n = 30) vs 35% (n = 29), p < 0.05), compared to reporting agree or lower. Qualitative analysis generated four themes: (1) A mentoring team promotes career advancement, (2) peer mentors are important at every stage of a CE’s career, (3) there is inadequate mentoring specific to CE needs, and (4) mentoring needs protected time and skill development. The traditional dyadic mentoring relationship may not adequately address all professional needs of CEs. A mentoring team can provide valuable perspectives on career goals. Peer mentoring can be powerful for professional growth. Mentoring needs change at different career stages and training in mentoring skills is essential.