cssi/SciSciGPT-SciSciNet huggingface dataset:
Inheritance of Tinted Eggshell Colors in White-Shell Stocks

The present study was conducted to study the genetics of tinted eggshell colors in two breeds of chickens laying white-shell eggs. Reciprocal crosses were made between an inbred White Leghorn line (ES) and an inbred Ancona line (ANC). The F1 birds were intercrossed and F1 females were backcrossed to each of the original lines. Eggshell color from each resultant group was measured using a Minolta chromometer, and a value (e) representing the color intensity adjusted by hue and saturation was used as the measurement criterion. Age, hatch group, and crosses each contributed significantly to the variation seen in eggshell color. Distribution comparisons indicated that two major autosomal loci affected the trait in these lines: one gene having incomplete dominance controls the amount of pigment deposition; the second completely inhibits pigment deposition when homozygous recessive. A test of goodness of fit supported this hypothesis. Genetic components were estimated by linear models. Epistasis, dominance, and additive effects contributed significantly to this trait. No sex-linked effects were noted.
Divine hiddenness and the nature of belief

In this paper we argue that attention to the intricacies relating to belief illustrate crucial difficulties with Schellenberg's hiddenness argument. This issue has been only tangentially discussed in the literature to date. Yet we judge this aspect of Schellenberg's argument deeply significant. We claim that focus on the nature of belief manifests a central flaw in the hiddenness argument. Additionally, attention to doxastic subtleties provides important lessons about the nature of faith.
Unsteady transonic flow over cascade blades

An attempt is made to develop an efficient staggered cascade blade unsteady aerodynamics model for the neighborhood of March 1, representing the blade row by a rectilinear two-dimensional cascade of thin, flat plate airfoils. The equations of motion are derived on the basis of linearized transonic small perturbation theory, and an analytical solution is obtained by means of the Wiener-Hopf procedure. Making use of the transonic similarity law, the results obtained are compared with those of other linearized cascade analyses. A parametric study is conducted to find the effects of reduced frequency, stagger angle, solidity, and the location of the pitching axis on cascade stability.
Genomic Estimated Breeding Values Using Genomic Relationship Matrices in a Cloned Population of Loblolly Pine

Replacement of the average numerator relationship matrix derived from the pedigree with the realized genomic relationship matrix based on DNA markers might be an attractive strategy in forest tree breeding for predictions of genetic merit. We used genotypes from 3461 single-nucleotide polymorphism loci to estimate genomic relationships for a population of 165 loblolly pine (Pinus taeda L.) individuals. Phenotypes of the 165 individuals were obtained from clonally replicated field trials and were used to estimate breeding values for growth (stem volume). Two alternative methods, based on allele frequencies or regression, were used to generate the genomic relationship matrices. The accuracies of genomic estimated breeding values based on the genomic relationship matrices and breeding values estimated based on the average numerator relationship matrix were compared. On average, the accuracy of predictions based on genomic relationships ranged between 0.37 and 0.74 depending on the validation method. We did not detect differences in the accuracy of predictions based on genomic relationship matrices estimated by two different methods. Using genomic relationship matrices allowed modeling of Mendelian segregation within full-sib families, an important advantage over a traditional genetic evaluation system based on pedigree. We conclude that estimation of genomic relationships could be a powerful tool in forest tree breeding because it accurately accounts both for genetic relationships among individuals and for nuisance effects such as location and replicate effects, and makes more accurate selection possible within full-sib crosses.
Behavioral and Psychological Symptoms of Dementia as a Risk Factor for Nursing Home Placement

Alzheimer's disease (AD) is the most common cause of dementia, affecting nearly 4 million older Americans (U.S. Department of Health and Human Services, 1996). Behavioral and psychological signs and symptoms of dementia (BPSD), especially agitated behaviors, affect nearly 80% of patients with AD (Jost & Grossberg, 1996). Researchers have speculated that BPSD, especially agitation, are the leading risk factors or triggers for nursing home (NH) admission in AD patients (Chenoweth & Spencer, 1986; Colerick & George, 1986). In this article, we review the literature on risk factors for NH placement in AD, and share preliminary data from an ongoing study at the Saint Louis University /Alzheimer's Association Brain Bank relative to the role of the BPSD as a risk factor for NH placement.
Causative Factors for ADHD: Role of Thyroid Stimulating Hormone Receptor in ADHD

Investigators from Meijo and Nagoya Universities, Nagoya, Japan, studied the role for thyroid stimulating hormone receptor (TSHR) in TSHR knockout mice with phenotypes of ADHD such as hyperactivity, impulsiveness, and impairment of short-term memory.
Education versus regulation: The case for regulating the indoor tanning industry

We examine marketing strategies for indoor tanning services that often target young adult females. Evidence of the addictive nature of indoor tanning suggests that young adults may be vulnerable to the promotion of indoor tanning and as a result deserve greater protection from the marketing of these services. As public awareness of the rising numbers of skin cancers linked to indoor tanning grows, we believe that the public will support increased regulation of this industry.
A Review of “ACT Made Simple: An Easy-to-Read Primer on Acceptance and Commitment Therapy”

In ACT Made Simple: An Easy-to-Read Primer on Acceptance and Commitment Therapy, Harris (2009) provides a practical and applicable explanation of Acceptance and Commitment Therapy (ACT), an empiric...
What Is Entrepreneurial Thinking

This paper presents "ten theses on entrepreneurial thinking" to highlight personal, institutional, social, and methodological aspects that characterize an entrepreneurial approach to economic and social problem-solving.
Viscoelastic Nonlinear Multilayered Model for Asphalt Pavements

AbstractFlexible pavements are multilayer structures, typically with a viscoelastic asphalt layer followed by nonlinear unbound/bound layers. Conventionally, multilayered elastic analysis is performed to obtain the response of flexible pavements for design and inverse analyses; however, assuming asphalt pavement to be a linear elastic material is an oversimplification of its actual behavior. It is well known that the responses of asphalt pavements are both rate and temperature dependent. In the present work, a computationally efficient model has been developed to analyze flexible pavements, considering the top layer of linear viscoelastic asphalt concrete (AC), followed by a stress-dependent (nonlinear) base layer, and an elastic subgrade. Constitutive equations are formulated for layered viscoelastic–nonlinear axisymmetric systems. It is shown that the developed model can be used to simulate pavement response under stationary or transient loading. A comparison between the model responses and results obta...
1,4,7-Trimethyloxatriquinane: SN2 Reaction at Tertiary Carbon

The synthesis of 1,4,7-trimethyloxatriquinane (1), a 3-fold tertiary alkyl oxonium salt, is described. Compound 1 is inert to solvolysis with alcohols, even at elevated temperatures, but undergoes facile substitution with the strongly nucleophilic azide anion. Since an SN1 pathway is excluded, the only reasonable mechanistic interpretation for the reaction between 1 and N3− is SN2, despite the fact that substitution is occurring at a tertiary carbon center. This finding is supported by computational modeling and a study of the reaction kinetics, and is also consistent with observed solvent and salt effects.
The effect of additives on the crystallization and sintering of 2MgO-2Al2O3-5SiO2 glass-ceramics

Crystallization and sintering behaviour of three cordierite (2MgO-2Al2O3-5SiO2) glasses containing different amount of additives were investigated and compared by using differential thermal analysis (DTA), X-ray diffraction (XRD), scanning electron microscopy (SEM), and the Archimedes method. The stoichiometric 2MgO-2Al2O3-5SiO2 (MAS) glass and the 2MgO-2Al2O3-5SiO2 glass containing 3 wt% of B2O3 and 3 wt% of P2O5 (MASBP) showed two exotherms (one for μ-cordierite formation from a glass and the other for α-cordierite formation from the μ-cordierite phase), whereas the 2MgO-2Al2O3-5SiO2 glass containing 2 wt % of B2O3, 2 wt% of P2O5, and 2 wt % of TiO2 (MASBPT) showed only a single exotherm representing α-cordierite formation. By using Kissinger, Augis-Bennett, Ozawa, and modified Kissinger methods, the activation energy values for α-cordierite formation in the MASBP and MASBPT glasses were determined as 310±6 and 326±13 kJ mol−1, respectively, whereas that in the MAS glass was determined as 868±5 kJ mol−1. The MASBPT glass showed the lowest peak temperature value for α-cordierite formation (980 °C) amongst the three glasses. Both the MASBP and MASBPT glasses showed excellent sintering behaviour (> 99.7% of theoretical density).
The New Religious Freedom: Secular Fictions and Church Autonomy

This article argues that a new form of religious freedom is emerging within the contentious field of United States politics today. Despite the commitment to separating church and state that is characteristic of American secularism, implementation of the new religious freedom appears likely to contribute to processes that are actively reshaping religious and political landscapes. Recent US Supreme Court cases such as Hosanna-Tabor v. EEOC and Burwell v. Hobby Lobby, Inc . present clear examples and this article uses the former case to bring the dynamics of the new religious freedom to light. The push for religious freedom in contemporary United States law and politics should be assessed in terms of its transformative consequences in both “religious” and “political” spheres. These consequences include refashioning religious communities as increasingly hierarchical and isolated enclaves, undermining the rights and freedoms of citizens, and further fracturing the public sphere.
Dermatosis and public health

Dermatosis is close related with public health.Through discussing the relation between dermatosis and public health,emphasize the prevention and management of dermatosis,build up the viewpoint of public health and strengthen the work of skin care.
EFFECT OF HIGH MAGNETIC FIELD ON SOLIDIFIED STRUCTURE OF Cu-80%Pb HYPERMONOTECTIC ALLOY

The solidification processes of Cu-80%Pb (mass fraction) hypermonotectic alloy were investigated at four experimental conditions.The formation process and morphology of Cu rich phase have been analyzed,and the influences of high magnetic field and cooling rate have been considered. The results show that the morphology of spherical Cu rich phases mainly has three kinds of microstruc- ture,that is the larger"net-shell type",the smaller"egg-type"and"eye-type".The cooling rate of the samples has great effect on both macrostructure and microstructure.As the cooling rate became slow,the Cu rich phase changed from the fine sphere to the larger floating sphere and the final coarse dendrite,the thickness of Cu-shell increased and net-like structure in Cu rich sphere phase coarsened; The 12 T high magnetic field has the effect on inhibiting the gravity segregation of Cu Pb alloy by preventing the floation of larger Cu rich droplets and deposition of Pb matrix,the macrostructure and microstructure of Cu-Pb monotectic alloy similar to those under a relative fast cooling rate formed. And the 12 T high magnetic field maybe has the effect to inhibit the transition of Cu solute both outside and inside of Cu rich sphere phase,the Cu rich shell and the Cu-Pb"net-like"phase are not coarsened.The magnetic drag force and final velocity of droplets is analyzed and calculated,to show the influence of magnetic field.
Uncertainty Quantification for LDDMM Using a Low-Rank Hessian Approximation

This paper presents an approach to estimate the uncertainty of registration parameters for the large displacement diffeomorphic metric mapping (LDDMM) registration framework. Assuming a local multivariate Gaussian distribution as an approximation for the registration energy at the optimal registration parameters, we propose a method to approximate the covariance matrix as the inverse of the Hessian of the registration energy to quantify registration uncertainty. In particular, we make use of a low-rank approximation to the Hessian to accurately and efficiently estimate the covariance matrix using few eigenvalues and eigenvectors. We evaluate the uncertainty of the LDDMM registration results for both synthetic and real imaging data.
Bottom-Up Energy Modeling

Author(s): Sathaye, Jayant; Sanstad, Alan H. | Abstract: Two general approaches have been used for the integrated assessment of energy demand and supply: the so-called bottom-up and top-down approaches. The bottom-up approach focuses on individual technologies for delivering energy services, such as household durable goods and industrial process technologies. For such technologies, the approach attempts to estimate the costs and benefits associated with investments in increased energy efficiency, often in the context of reductions in greenhouse gas (GHG) emission or other environmental impacts. The top-down method assumes a general equilibrium or macroeconomic perspective, wherein costs are defined in terms of losses in economic output, income, or gross domestic product (GDP), typically from the imposition of energy or emission taxes.
The New Centrality: The Impact of Telematics and Globalization

Publisher Summary This chapter discusses the formation of a single European market and financial system that raise the possibility and even the need if it is to be competitive, of centralizing financial functions and capital in a limited number of cities rather than maintaining the current structure in which each country has an international financial center. In the case of a complex landscape such as Europe's, there are several geographies of centrality, one global, others continental, and regional. A central urban hierarchy connects major cities, many of which in turn play central roles in the wider global system of cities: Paris, London, Frankfurt, Amsterdam, and Zurich. Moreover, these cities are part of a wider network of European financial/cultural/service capitals, some with only one, others with several, of the functions that articulate the European region and are somewhat less oriented to the global economy than Paris, Frankfurt, or London. The chapter also describes cyberspace. The cyberspaces of finance are spaces where profits are produced and power is thereby constituted. Insofar as these technologies strengthen the profit making capability of finance and make possible the hyper-mobility of finance capital, they also contribute to the often devastating impacts of the ascendance of finance on other industries, on particular sectors of the population, and on whole economies.
Summary and conclusions, and some possible future scenarios

The United States has had considerable difficulty in adhering to the rule of law in its conduct of foreign affairs. However, there also have been occasions when the United States has taken the lead in supporting the rule of law in resolving some of the major international issues. There has been, in other words, a substantial degree of inconsistency in the US record. This chapter consists of two parts: a summary and conclusions, based on an examination of the preceding nine chapters; and some possible future scenarios relevant to the United States and the rule of law in international affairs. Summary and conclusions Deviations from the rule of law US deviations from the rule of law, especially in recent years, have been numerous. These deviations have taken a variety of forms, and some of them have engendered considerable controversy. Some might cite the treaties that the United States has rejected in the face of overwhelming support from most other countries, including most particularly close US allies. These include, among others, the Statute of the International Criminal Court, the Landmines Treaty, the Comprehensive Nuclear Test Ban Treaty, the Kyoto Treaty, the Biological Diversity Treaty, the Law of the Sea Treaty, and the proposed Protocol to the Biological Weapons Convention. The United States also has been called to task for withdrawing from the ABM Treaty, although it did so in accordance with the terms of the treaty, and for refusing to explore means to eliminate or at least limit the global illicit trade in small arms and light weapons.
Theory and Experiment of Binary Diffusion Coefficient of n-Alkanes in Dilute Gases.

Binary diffusion coefficients were measured for n-pentane, n-hexane, and n-octane in helium and of n-pentane in nitrogen over the temperature range of 300 to 600 K, using reversed-flow gas chromatography. A generalized, analytical theory is proposed for the binary diffusion coefficients of long-chain molecules in simple diluent gases, taking advantage of a recently developed gas-kinetic theory of the transport properties of nanoslender bodies in dilute free-molecular flows. The theory addresses the long-standing question about the applicability of the Chapman-Enskog theory in describing the transport properties of nonspherical molecular structures, or equivalently, the use of isotropic potentials of interaction for a roughly cylindrical molecular structure such as large normal alkanes. An approximate potential energy function is proposed for the intermolecular interaction of long-chain n-alkane with typical bath gases. Using this potential and the analytical theory for nanoslender bodies, we show that the...
A monolithic 1 to 50 GHz distributed amplifier with 20 dBm output power

A monolithic 1 to 50 GHz distributed amplifier has been developed using a MODFET IC process to demonstrate a saturated power in excess of 20 dBm. The power output at the -1 dB gain compression point is greater than 18 dBm across the frequency range. The small signal gain is 8.5 dB+or-0.3 dB, and both input and output return loss are less than -10 dB. Physical layout considerations placed constraints on the design that resulted in a compromise between gain, RF voltage drive, and gain flatness. >
The Critical Role of Imaging in the Management of Multiple Myeloma

Multiple myeloma (MM) is characterized by abnormal proliferation of plasma cells in the bone marrow leading to symptoms of anemia, renal failure, hypercalcemia, and bone lesions. Bone imaging is critical for the diagnosis, staging, assessment for the presence and extent of bone lesions, and initial treatment of MM. Skeletal survey is the preferred initial imaging modality due to its availability and low cost. However, it has poor sensitivity and patients with occult myeloma may escape detection, delaying their diagnosis and treatment. New cross-sectional imaging modalities such as low-dose whole body CT, MRI, and PET-CT have high sensitivity and specificity for detecting lytic lesions and extramedullary relapse in MM. The combined use of cross-sectional imaging may provide complimentary information for staging, prognosis, and disease monitoring. In this review, we will discuss commonly used imaging modalities and their advantages and disadvantages in the management of MM.
Look on the Bright Side (of Media Effects): Pokémon Go as a Catalyst for Positive Life Experiences

ABSTRACTThis study examined whether playing an augmented reality (AR) video game might benefit players’ psychological well-being. Specifically, it tested predictions afforded by integrating the broaden-and-build theory within the framework of the Differential Susceptibility to Media Effects model. An online survey of 399 U.S. adults aged 18–75 indicated that playing the AR game Pokemon Go was associated with various positive responses (increased positive affect, nostalgic reverie, friendship formation, friendship intensification, and walking), most of which predicted enhanced well-being. Additionally, two indirect effects of gameplay were moderated by social anxiety. For highly anxious participants, gameplay showed weaker associations with positive affect (a predictor of enhanced well-being), but also weaker associations with nostalgic regret (a predictor of reduced well-being).
Towards Understanding Differential Privacy: When Do People Trust Randomized Response Technique?

As a consequence of living in a data ecosystem, we often relinquish personal information to be used in contexts in which we have no control. In this paper, we begin to examine the usability of differential privacy, a mechanism that proposes to promise privacy with a mathematical "proof" to the data donor. Do people trust this promise and adjust their privacy decisions if the interfaces through which they interact make differential privacy less opaque? In a study with 228 participants, we measured comfort, understanding, and trust using a variant of differential privacy known as Randomized Response Technique (RRT). We found that allowing individuals to see the amount of obfuscation applied to their responses increased their trust in the privacy-protecting mechanism. However, participants who associated obfuscating privacy mechanisms with deception did not make the "safest" privacy decisions, even as they demonstrated an understanding of RRT. We demonstrate that prudent privacy-related decisions can be cultivated with simple explanations of usable privacy.
Biomechanical Implications of an Oblique Knee Joint Line.

Surgical correction of multiapical deformities of the lower limb requires careful preoperative planning. Surgeons must account for the potential creation of secondary deformity, such as knee joint line obliquity, and the risks associated with accepting these changes in limb alignment. In this study, we evaluate the effect of knee joint obliquity on tibial plateau contact pressures and knee instability. Three cadaveric knees were dissected and put through biomechanical testing to simulate loading of an oblique knee joint. We observed
Beyond BRCA: A Case Series Examining the Advent of Multigene Panel Testing

Since the discovery of BRCA1 and BRCA2 , our understanding of hereditary breast cancer has grown exponentially with the continued discovery of novel associated genes. As a result, the utilization of multigene panel testing has become increasingly more common with time and the number of genes tested in panels continues to parallel that growth. However, despite the surplus of data regarding gene association with hereditary breast cancer, there has been a significant lag in clinical outcome data and recommendations regarding these novel genes. When the implication of an associated gene is uncertain, it is termed a variant of uncertain significance (VUS), and until they are able to be reclassified in terms of their clinical relevance, VUS have created significant difficulty for both patients and physicians alike with regard to the interpretation of positive results. Despite this, the utilization of multigene panel testing has displayed many expected and unexpected benefits. Here we examine a case series of the RAD50, CHEK2, and PTEN , three known genes that, when mutated, confer a relatively low, intermediate, and high lifetime risk for breast cancer, respectively. Through these genes, we explore the pros and cons of the adoption of multigene panel testing and address prudent questions and concepts pertinent to its continued use into the future.
Extracorporeal Membrane Oxygenation in Pulmonary Endarterectomy Patients.

Objectives To investigate short-term outcomes in patients with chronic thromboembolic pulmonary hypertension (CTEPH) presenting for pulmonary endarterectomy (PEA) and requiring extracorporeal membrane oxygenation (ECMO) during the perioperative period. Design Retrospective observational case series involving patients who underwent PEA for CTEPH, with focus on a subpopulation requiring perioperative ECMO support. Setting Single academic tertiary center. Participants Patients who underwent PEA for CTEPH between January 1997 and December 2015 and required ECMO support. Interventions PEA for CTEPH with ECMO support at any time during the perioperative period. Measurements and Main Results A total of 150 patients underwent PEA for CEPTH during the study period. Of the 150 patients, 14 (9.3%) required ECMO support and (43%) survived, were discharged, and were alive at the time of the review. A total of 8 (57%) ECMO patients died during hospitalization. Although indications and type of support changed in some patients during their hospital course, the majority of patients required venovenous ECMO support for hypoxia (N = 9) versus venoarterial ECMO for hemodynamic support (N = 5) as initial indication. The mean length of stay among survivors was 42.2 ± 22 days. Severe RV dysfunction was present preoperatively among 6 patients in the nonsurvivors group (75%) and 2 in the survivors group (33%). The overall mean duration of ECMO support was 7.3 ± 5.3 days (8.3 ± 7.3 days among survivors and 6.5 ± 3.5 days among nonsurvivors). Four patients died while on ECMO. Conclusions Although still associated with high morbidity and mortality, ECMO appears to be an important treatment adjunct providing additional time for healing and recovery of cardiopulmonary function in patients who develop severe hypoxemia or right ventricular failure after PEA.
Update on the diagnosis of and therapy for acute promyelocytic leukemia and chronic myelogenous leukemia.

Purpose/objectives To present information about recent Food and Drug Administration (FDA)-approved indications regarding drug therapy for acute promyelocytic leukemia (APL) and chronic myelogenous leukemia (CML) and about the nursing care of patients receiving these therapies and to review the significance of the use of polymerase chain reaction (PCR) assays in the management of patients with these leukemias. Data sources Published articles, book chapters, and production information. Data synthesis Two agents with newly approved FDA indications are changing the focus of leukemia treatment from the cytotoxicity of specific drugs to the reversal of arrested maturation of myeloid cells. All-trans-retinoic acid (ATRA) induces remission in patients with relapsed or refractory APL. Interferon alfa (IFN-alpha) administered to patients with chronic-phase, Philadelphia-chromosome-positive CML produces improved survival rates and delays disease progression as compared to standard therapy. PCR assays are used with both of these diseases to confirm diagnosis, monitor response to these agents, and predict disease progression. Conclusions The care of patients with leukemia continues to change as new agents such as ATRA and are approved for treatment and new assays such as PCR become available for diagnosis and treatment monitoring. Implications for nursing practice The nursing care of patients with leukemia requires keeping knowledgeable about the latest information regarding the molecular biology of the disease, the mechanism of action of newly approved agents, and the clinical implications of developing tests. This knowledge allows nurses to assimilate new therapies into practice, which, in turn, enables them to help patients to understand and cope with treatment through patient education and innovative interventions for symptom management.
Influence of Extrusion Processing Variables on the Microstructure and Mechanical Properties of Aluminum-Lithium Alloy Extrusions

Extrusion temperature, strain rate, extrusion ratio, billet temperature, and extrusion geometry were varied, and correlated with the microstructure of the alloy, and the heat treating times and temperatures. The extrusion processing variables were related to the microstructure through the Zener-Hollomon parameter i.e., the temperature compensated strain rate. Based on optical and transmission electron microscopy studies it was found that regardless of the extrusion conditions, the various microstructures were for the most part were unrecrystallized for both the asextruded and the solution heat treated conditions. Smaller grain sizes were correlated to smaller Zenor-Hollomon parameters. The extrusion temperature and ratio did not significantly effect the strength or elongation. The section geometry did effect these mechanical properties.
Scalable, Peer-Based Mediation Across XML Schemas and Ontologies

Research on the Semantic Web has focused on reasoning about data that is semantically annotated in the RDF data model, with concepts and properties specified in rich ontology languages such as OWL. However, to flourish, the Semantic Web needs to provide interoperability both between sites with different ontologies and with existing, non-RDF data and the applications operating on them. To achieve this, we are faced with two problems. First, most of the world’s data is available not in RDF but in XML; XML and the applications consuming it rely not only on the domain structure of the data, but also on its document structure. Hence, to provide interoperability between such sources, we must map between both their domain structures and their document structures. Second, data management practitioners often prefer to exchange data through local point-to-point data translations, rather than mapping to common mediated schemas or ontologies.
Depression, Hopelessness, Optimism, and Health

Depression is a syndrome involving sadness and pessimism plus loss of motivation and the ability to experience enjoyment. Pessimism as a trait is a generalized expectancy of negative outcomes in important life domains; hopelessness conveys a similar sense of anticipating bad outcomes. All these qualities have been implicated as contributors to adverse health outcomes. Pessimism has been related to lower persistence at health promotion and to activities that reflect disengagement from life. Pessimism has also been linked to adverse reactions to the events of coronary artery bypass surgery and heart transplantation. In a similar manner, symptoms of long-term disease develop faster in persons with fatalistic giving-up responses, and active engagement has been related to lower likelihood of cancer recurrence and longer survival times. Depression has been related to elevated likelihood of cardiac death after myocardial infarction. There is some evidence that such effects of psychological variables are greater among younger than older persons. Future research must focus more on the pathways by which these variables create their influence.
Integration of Cognitive-Behavioral and Interpersonal Therapies for Latinos: An Argument for Technical Eclecticism

The integration of psychotherapeutic techniques is a common practice among today's clinicians. However, most discussions on psychotherapy integration have focused on general theoretical issues without attention to special populations. Latinos now represent the largest ethnic minority population in the United States and the mental health needs of this population are increasing. Although there are few controlled outcome studies that focus on Latinos, basic research suggests that integrating components of interpersonal therapy (IPT) into cognitive-behavioral therapy (CBT) may be particularly effective with this population. Specific suggestions for integrating CBT and IPT techniques are presented, and ways in which this integration can be adapted in a culturally sensitive manner are reviewed. An ethical and culturally sensitive CBT-IPT integration for Latinos requires empirical verification. Future studies on CBT-IPT synthesis should demonstrate the effectiveness of such integration relative to CBT or IPT alone.
Efficiency Analyze of Conformal SCMR System for Wearable Applications

Multiple scenarios of using a Conformal Strongly Coupled Magnetic Resonance (SCMR) system for wireless power transfer (WPT) will be studied. The effects of the CSCMR will be studied on different parts of the body as well as embedded in pork to represent the human flesh. The test points on the human body are shown in the figure below. We will analyze the SCMR systems response on different part of human body operating environments and the impact they have on the efficiency of operation. Our analysis is conducted through accurate simulations and validated through physical implementation.
Gemcitabine, docetaxel, and capecitabine (GTX) as a first-line regimen in metastatic pancreatic adenocarcinomas (mPAC): A single institution experience.

385Background: After decades of minimal to no therapeutic options, Gemcitabine emerged as the only safe & effective frontline regimen for mPAC. A 3-drug combination regimen, GTX, first optimized by...
Challenging problems in Euclidean geometry

The purpose of this note is to describe several challenging problems in Euclidean geometry. The note also contains author’s solution sketches to the two problems. All life is problem solving....
The role of water in unconventional in situ energy resource extraction technologies: Chapter 7 in Food, energy, and water: The chemistry connection

Global trends toward developing new energy resources from lower grade, larger tonnage deposits that are not generally accessible using “conventional” extraction methods involve variations of subsurface in situ extraction techniques including in situ oil shale retorting, hydraulic fracturing of petroleum reservoirs, and in situ recovery of uranium. Although these methods are economically feasible and perhaps result in a smaller above-ground land-use footprint, there remain uncertainties regarding potential subsurface impacts to groundwater. This chapter provides an overview of the role of water in these technologies and the opportunities and challenges for water reuse and recycling.
The Costs of Applying to Residency: One Institution's Efforts to Increase Transparency.

Objectives To provide students at our own institution with more accurate and granular data regarding the costs associated with applying for residency. Methods We created an electronic survey with >28 different fields delineating the costs associated with applying for residency. Demographic data, costs broken down by type of expenditure, and how these costs were financed were measured. Each year, graduating students at our institution took the survey in 2015, 2016, 2017, and 2018 before The Match. We then created a dynamic, user-friendly, and interactive Web-based application to display these data numerically and graphically for students to use while planning and preparing for The Match. Results There was a response rate of 48.9% (194/397). Overall, students completed an away rotation at a median of 1.0 (interquartile range [IQR] 0-2.0) programs and spent $1000 (IQR $292-$1606) per away rotation. They applied to a median of 30.0 (IQR 20.0-47.8) categorical programs and attended 12.0 (IQR 10.0-16.0) interviews. The cost per interview was $282 (IQR $192-$407). The total expenditures for preparing for residency were $4992 (IQR $3034-$8,274). These numbers varied significantly by intended specialty. Differences were noted between our data and those from both a regional and recent national cohort. Conclusions The costs associated with applying for residency are relatively unknown and can be significant for some. Institutionally led efforts may allow students to more appropriately plan and budget for The Match. Other institutions may benefit from a similar program.
Characterizing Palliative Radiotherapy Education in Hospice and Palliative Medicine Fellowship: A Survey of Fellowship Program Directors.

Background: Educational deficiencies among hospice and palliative medicine (HPM) physicians contribute to suboptimal utilization of palliative radiotherapy (PRT) for patients with advanced cancer. ...
Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen-Specific T Cells.

Purpose: Surgical resection of primary tumor with regional lymphadenectomy remains the treatment of choice for patients with advanced human papillomavirus–negative head and neck squamous cell carcinoma. However, even when pathologic disease-free margins can be achieved, locoregional and/or distant disease relapse remains high. Perioperative immunotherapy may improve outcomes, but mechanistic data supporting the use of neoadjuvant or adjuvant treatment clinically are sparse. Experimental Design: Two syngeneic models of oral cavity carcinoma with defined T-cell antigens were treated with programmed death receptor 1 (PD-1) mAb before or after surgical resection of primary tumors, and antigen-specific T-cell responses were explored with functional and in vivo challenge assays. Results: We demonstrated that functional immunodominance developed among T cells targeting multiple independent tumor antigens. T cells specific for subdominant antigens expressed greater levels of PD-1. Neoadjuvant, but not adjuvant, PD-1 immune checkpoint blockade broke immunodominance and induced T-cell responses to dominant and subdominant antigens. Using tumors lacking the immunodominant antigen as a model of antigen escape, neoadjuvant PD-1 immune checkpoint blockade induced effector T-cell immunity against tumor cells lacking immunodominant but retaining subdominant antigen. When combined with complete surgical excision, neoadjuvant PD-1 immune checkpoint blockade led to formation of immunologic memory capable of preventing engraftment of tumors lacking the immunodominant but retaining subdominant antigen. Conclusions: Together, these results implicate PD-1 expression by T cells in the mechanism of functional immunodominance among independent T-cell clones within a progressing tumor and support the use of neoadjuvant PD-1 immune checkpoint blockade in patients with surgically resectable carcinomas.
STAT3-miR-17/20 signalling axis plays a critical role in attenuating myocardial infarction following rapamycin treatment in diabetic mice

Aims Deregulation of mTOR (mammalian target of rapamycin) signalling occurs in diabetes, which exacerbates injury following myocardial infarction (MI). We therefore investigated the infarct-limiting effect of chronic treatment with rapamycin (RAPA, mTOR inhibitor) in diabetic mice following myocardial ischaemia/reperfusion (I/R) injury and delineated the potential protective mechanism. Methods and results Adult male diabetic (db/db) or wild-type (WT) (C57) mice were treated with RAPA (0.25 mg/kg/day, intraperitoneal) or vehicle (5% DMSO) for 28 days. The hearts from treated mice were subjected to global I/R in Langendorff mode. Cardiomyocytes, isolated from treated mice, were subjected to simulated ischaemia/reoxygenation (SI/RO) to assess necrosis and apoptosis. Myocardial infarct size was increased in diabetic heart following I/R as compared to WT. Likewise, enhanced necrosis and apoptosis were observed in isolated cardiomyocytes of diabetic mice following SI/RO. Treatment with RAPA reduced infarct size as well as cardiomyocyte necrosis and apoptosis of diabetes and WT mice. RAPA increased STAT3 phosphorylation and miRNA-17/20a expression in diabetic hearts. In addition, RAPA restored AKT phosphorylation (target of mTORC2) but suppressed S6 phosphorylation (target of mTORC1) following I/R injury. RAPA-induced cardioprotection against I/R injury as well as the induction of miR-17/20a and AKT phosphorylation were abolished in cardiac-specific STAT3-deficient diabetic mice, without alteration of S6 phosphorylation. The infarct-limiting effect of RAPA was obliterated in cardiac-specific miRNA-17-92-deficient diabetic mice. The post-I/R restoration of phosphorylation of STAT3 and AKT with RAPA were also abolished in miRNA-17-92-deficient diabetic mice. Additionally, RAPA suppressed the pro-apoptotic prolyl hydroxylase (Egln3/PHD3), a target of miRNA-17/20a in diabetic hearts, which was abrogated in miRNA-17-92-deficient diabetic mice. Conclusion Induction of STAT3-miRNA-17-92 signalling axis plays a critical role in attenuating MI in RAPA-treated diabetic mice. Our study indicates that chronic treatment with RAPA might be a promising pharmacological intervention for attenuating MI and improving prognosis in diabetic patients.
Heavy metal content of produce grown in San Juan County (New Mexico, USA)

The Animas River Watershed has long received discharges of naturally occurring acid rock drainage; however, on August 5, 2015, three million gallons flowed into the agricultural region of Farmingto...
Cardiac allograft rejection in the current era of continuous flow left ventricular assist devices

Abstract Objective Left ventricular assist device (LVAD) implantation has been shown to increase allosensitization before orthotopic heart transplantation, but the influence of LVAD support on posttransplant rejection is controversial. This study examines the postoperative incidence of acute cellular rejection (ACR) in patients bridged with continuous flow LVAD (CF-LVAD) relative to primary transplant (Primary Tx). Methods All patients who underwent orthotopic heart transplantation at our institution between July 2006 and March 2019 were retrospectively reviewed (n = 395). Patients were classified into Primary Tx (n = 145) and CF-LVAD (n = 207) groups. Propensity score matching on 13 covariates implemented a 0.1 caliper logistic model with nearest neighbor 1:1 matching. Development of moderate to severe (ie, 2R/3R) rejection was evaluated using a competing risks model. Potential predictors of 2R/3R ACR were evaluated using Fine-Gray regression on the marginal subdistribution hazard. Results Propensity score matching yielded 122 patients in each group (n = 244). At 12 and 24 months, the cumulative incidence of 2R/3R ACR was 17% and 23% for the CF-LVAD group and 26% and 31%, respectively, for the Primary Tx group (P = .170). CF-LVAD was not predictive of 2R/3R rejection on multivariable Fine-Gray regression (subdistribution hazard ratio, 0.73; 95% confidence interval, 0.40-1.33; P = .301). There was no difference in the 5-year incidence of antibody mediated rejection (10% [n = 12] vs 9% [n = 11]; P = .827). Conclusions After adjusting for covariates, CF-LVAD was not associated with an increased risk of moderate to severe ACR during the 24 months after cardiac transplantation. Further investigation is warranted with larger cohorts, but CF-LVAD may have minimal influence on posttransplant ACR.
Modernism, Inflation, and the Gold Standard

Following World War One, economic issues like the gold standard and German inflation raised inescapable questions about how money represents value. Such issues had clear implications for other kinds of representation. Differences between the economic opinions of Ezra Pound, T. S. Eliot, and Ernest Hemingway paralleled a divergence between their theories of the poetic symbol. Pound regarded Eliot’s employment by Lloyds Bank as usurious and therefore incompatible with the practice of poetry, while Eliot considered that his job aided rather than hindered his writing. The connections between usury, representation and sexuality loom large in the seminal modernist novel, Hemingway’s The Sun Also Rises. They also feature in the economic work produced by the Harold Loeb, the model for Hemingway’s Jewish victim-figure, Robert Cohn.
Lowering the Barrier to C–H Activation at IrIII through Pincer Ligand Design

Selective C–H activation of benzene and n-octane under mild conditions by a pincer IrIII carboxylate complex, (CCCMesityl)Ir(OAc)2(OH2) (1a), is described. A kinetic study of benzene activation was...
Blogometrics

This study gathers information on a wide array of economics bloggers and blogs in order to develop a ranking of economics bloggers that is based on citations to their academic research. This ranking is used in an iterative process that next presents a ranking of economics blogs that is based on the ranking of economics bloggers, and finally a ranking of economics departments that is based on the ranking of economics blogs. The ranking of blogs included in this study is positively correlated with an external ranking based on their productivity (popularity), whereas the department ranking presented here comports quite well with department rankings in Coupe (2003) and Roessler (2004) that are developed with more traditional measures, such as the impact of the scholarship of an economics department's faculty.
New Bedford Hurricane Barrier Operational Problems

Operation of a hurricane barrier with a navigation opening requires the cooperation of those situated on floodprone lands behind the barrier and shipping interests who continually travel through the opening to use the docking facilities in the harbor. The closure criteria at New Bedford for coastal storms has undergone several revisions based upon experience gained during actual operations. The latest criteria takes into account not only the predicted tide and surge but also the windspeed and direction. Many operational problems still exist. The most important are the predictions of tidal surges from undetected coastal storms that form rapidly south of the New England coast and also from storms located several hundred miles east of the New England coast. By telemetering the tide data to the Cape Cod Canal office, which is staffed 24 hr a day, it is expected barrier personnel will be alerted in time to operate the New Bedford hurricane barrier for these types of abnormal tides.
Toward Conflict or Compromise? How Aggressive Cues Polarize (or Moderate) Partisan Attitudes

When will partisans take more polarized policy positions apt for conflict, and when will they adopt conciliatory stances toward compromise? We argue that aggressive cues in everyday political speech signal approaching hostilities, and that partisans respond to these cues by aligning closer with partisan views before the clash or by seeking middle ground less tied to partisanship. These distinct responses to signs of conflict, we suggest, depend on each partisan’s orientation toward aggression in everyday life. In two survey experiments, we find considerable support for our predictions: exposure to violent metaphors increases partisan differences on policy views among aggressive citizens but reduces differences among low-aggression partisans. These findings reveal the hidden power of aggression in public opinion, they highlight the conditional nature of polarization dynamics, and they speak to the normative challenge that even mild language poses for political conflict among leaders and citizens.