cssi/SciSciGPT-SciSciNet huggingface dataset:
Automatic synthesis of communication-based coordinated multi-robot systems

To enable the successful deployment of task-achieving multi-robot systems (MRS), coordination mechanisms must be utilized in order to effectively mediate the interactions between the robots and the task environment. Over the past decade, there have been a number of elegant experimentally demonstrated MRS coordination mechanisms. Most of these mechanisms have been task-specific in nature, typically providing only empirical insights into coordination design and little in the way of systematic techniques to assist in the design of coordinated MRS for new task domains. To fully realize the potentials of MRS, formally-grounded systematic techniques amenable to analysis are needed in order to facilitate the design of coordinated MRS. We address this problem by presenting a formal framework for describing and reasoning about coordination in a MRS. Using this principled foundation, we are developing a suite of general methods for automatically synthesizing the controllers of robots constituting a MRS such that the given task is performed in a coordinated fashion. This paper presents a method for the automatic synthesis of a specific type of controller, one that is stateless but capable of inter-robot communication. We also present a graph coloring-based approach for minimizing the number of necessary unique communication messages. The synthesis of such communicative controllers provides a means for assessing the uses and limitations of communication in MRS coordination. We present experimental validation of our formal approach of controller synthesis in a multi-robot construction domain through physically-realistic simulations and in real-robot demonstrations.
Right middle lobe atelectasis in childhood asthma

Abstract Three cases of reversible atelectasis of the right middle lobe, which occurred within a short period of time in children hospitalized for acute bronchial asthma, are reported. By frequent roentgenologic monitoring of the pulmonary findings the collapse of this vulnerable lobe can be detected early and, by vigorous therapy, re-expansion of the atelectatic lobe can be achieved; otherwise the atelectasis might lead to long-standing disease in the nonaerated lung areas. The clinical entity of right middle lobe collapse as a result of severe bronchial asthma is contrasted with the often referred to "right middle lobe syndrome" which constitutes either a structural anomaly of the right middle lobe bronchus itself or its compression by grossly enlarged lymph nodes surrounding the origin of that bronchus. This differentiation is considered to be important since the latter condition often warrants surgical intervention, while the former should respond to competent antiasthmatic management. Without continued vigilance, however, long-standing atelectasis of any lobe from any cause may lead to permanent damage to the involved tissue, primarily bronchiectasis and lung abscesses, and eventually require lobectomy.
Relation of smoking at baseline and during trial years 1-6 to food and nutrient intakes and weight in the special intervention and usual care groups in the Multiple Risk Factor Intervention Trial.

This chapter describes dietary composition ac- cording to cigarette smoking status at baseline and changes in smoking status during follow-up for men in the special interven- tion (SI) and usual care (UC) groups of the Multiple Risk Factor Intervention Trial. Five patterns of smoking behavior were de- fined: 1) sustained nonsmoking, 2) early (years 1-2 of the trial) sustained quitting, 3) late (years 3-6 of the trial) sustained quitting, 4) recidivism, and 5) continued smoking. SI men who quit smok- ing showed greater favorable changes in dietary lipid composition and micronutrient intake than did continued smokers, and these changes were in many instances as great as favorable changes made by nonsmokers. On the other hand, SI men who quit smok- ing gained an average of 3.8 lb (1.7 kg), in contrast with nonsmok- ers who lost an average of 6.4 lb (2.9 kg). The gain by SI quitters was, however, less than that by UC quitters, who gained 6.5 lb (3.0 kg). Moreover, despite weight gain, net change in high-density- lipoprotein (HDL) cholesterol for SI quitters was positive. With the associated decrease in low-density-lipoprotein (LDL) choles- terol, early SI quitters had the most improvement in ratio of LDL to HDL among all subgroups. Thus, unfavorable nutritional pat- tems of smokers put them at double jeopardy regarding cardio- vascular and other chronic diseases; additionally, long-term risks can be improved not only by smoking cessation but also by achievement of healthier eating patterns. Am J Clin Nutr 1997;65(suppl):374S-402S.
Geriatrics: Contemporary and Future Concerns

1. Salivary Hypofunction and Xerostomia in the Elderly: Diagnosis and Treatment (Atkinson) 2. Derangment, Osteoarthritis and Rheumatoid Arthritis of the TMJ: Implications, Diagnosis and Management (Broussard) 3. Orofacial Pain and Sensory Disorders in the Elderly (Clark) 4. Interactions with Other Health Team Members in Caring for Elderly Patients (Durso) 5. Underserved Elderly Issues (Greene) 6. Caring for Elderly Long Term Care Patients: What are the Concerns? (MacEntee) 7. Oral Diagnostics for the Geriatric Populations: Current Stats and Future Prospects (Malamud) 8. Dental Caries in Elder Adults (Meyerowitz) 9. The Elderly at Risk for Periodontitis and Systemic Diseases (Persson) 10. Nutrition, Oral Health and Aging (Saunders) 11. Use and Prescribing Considerations for Elderly Patients (Williams) 12. Cognitive Function, Aging and Ethical Decisions: Recognizing Change (Yellowitz)
The Work Values Of Accounting Students

Prior research has shown the importance of the work values of Achievement, Security, Civility and Autonomy in examining the accounting profession. This paper provides measures of these four work values in a sample of 502 accounting majors and fifty-three accounting faculty from ten schools. Statistical analysis indicates some significant differences in work value scores of female vs. mail students and faculty vs. students. In addition to discussing the results of the study, we also suggest how the research instrument and data may serve as focal points for discussions, lectures, and research projects by consultants, in-house training personnel and university professors.
Genomics innovation: transforming healthcare, business, and the global economy.

The genomics revolution has generated an unprecedented number of assets to propel innovation. Initial availability of genomics-based applications show a significant potential to contribute addressi...
Trust Within Contesting Alliance Contexts

Strategic alliances are considered significant corporate strategy for reducing the investment risk, transferring competence and resources, and entering global markets. Despite their widespread use, alliances are reported to be risky and ineffective. Extant research suggests that legal and contractual controls are inadequate for managing the alliances because of the complex industry and global contexts that affect the alliances. Thus, it is critical to study the role of relational dynamics such as trust in the success of alliances, and examine whether the relationships between partners can withstand the contesting alliance contexts. Employing the relational exchange perspective, this study systematically examines the influence of trust between partners on the alliance performance, and further tests whether the alliance relationships are strengthened or restrained by the national differences, governance mode, and rivalry and power dynamics between the partners. This study, based on data collected from the managers of 179 strategic alliances, revealed that trust between partners is related to alliance performance, and found evidence that this relationship is moderated by alliance contexts such as international scope, alliance governance mode, and rivalry between partners.
Increase in primary surgical treatment of T1 and T2 oropharyngeal squamous cell carcinoma and rates of adverse pathologic features: National Cancer Data Base.

BACKGROUND There has been increasing interest in the primary surgical treatment of patients with early T classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de-escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest has translated into changes in practice patterns, and the rates of adverse postoperative pathologic features. METHODS Patients with T1 to T2 OPSCC in the National Cancer Data Base who were treated from 2004 through 2013 were categorized as receiving primary surgical or primary radiation-based treatment. Trends in treatment selection and factors related to the selection of primary surgery were examined. The rates of adverse pathologic features including positive surgical margins, extracapsular spread (ECS), and advanced T and N classifications after surgery were analyzed. RESULTS Of 8768 patients with T1 to T2 OPSCC, 68% underwent primary surgical treatment, increasing from 56% in 2004 to 82% in 2013 (P<.0001). The highest versus lowest volume hospitals treated 78% versus 59% of patients with primary surgery (odds ratio, 2.23; 95% confidence interval, 1.55-3.22 [P<.0001]). Higher lymph node classification was found to be predictive of lower rates of primary surgery, but the majority of patients with clinical N2/N3 disease underwent primary surgery. Among patients treated with surgery, positive surgical margins were present in 24% and ECS in 25% of patients. The rate of positive surgical margins decreased over time (P<.0001) and was observed less often at high-volume centers (P<.0001). Among candidates for single-modality therapy (those with clinical T1-T2/N0-N1 disease), 33% had positive surgical margins and/or ECS and 47% had at least 1 adverse feature (T3-T4 disease, N2-N3 disease, positive surgical margins, and/or ECS). CONCLUSIONS Primary surgical treatment among patients with early T classification OPSCC has become more widespread. Cancer 2016. © 2016 American Cancer Society.
Spontaneous right-sided microcavitations in a healthy adult.

Spontaneous echo contrast (SEC) is frequently observed in patients with structural and functional cardiovascular abnormalities. Literature describes cases of SEC either from agglutination of red blood cells and plasma proteins or from microcavitations. SEC secondary to the former is an independent predictor of future thromboembolic events and is most commonly observed in the left atrium or left atrial appendage. Thus, many authors reason that left atrial SEC is an indication for initiating anticoagulant therapy. We report a rare case of right atrial SEC that was incidentally found during echocardiographic evaluation of isolated peripheral edema in a healthy adult with a structurally normal heart. At present, there are no studies to offer guidance for management of right atrial SEC. This case emphasizes a necessary area of future research. Learning points Cardiovascular implications of SEC. Diagnostic evaluation and management of SEC.
Decision making for upper instrumented vertebra in thoracolumbar/lumbar adolescent idiopathic scoliosis: can we stop below the end vertebra?

Commentary On Sudo H, Kaneda K, Shono Y, Iwasaki N. Selection of the upper vertebra to be instrumented in the treatment of thoracolumbar and lumbar adolescent idiopathic scoliosis by anterior correction and fusion surgery using dual-rod instrumentation: a minimum 12-year follow-up study. Spine J. 2016:16:281–7 ( in this issue ).
Complex governance system issues for transportation renewal projects

The use of public–private partnerships (PPPs) is growing in the United States in response to reductions in funding combined with an aging highway transportation infrastructure. Many other countries have longer experience with PPP and a greater understanding of the issues surrounding their use. The main governance issues to be addressed in PPPs deal with risk-sharing, relationships, contracts, and legal framework, and standard processes within dedicated organizational units. These governance issues are examined in the context of a case study for the US 36 Phase II PPP in Colorado. Findings suggest that for the US Phase II project, governance issues are resolved through more relational forms than prescriptive contractual language. Colorado has established a dedicated organizational unit to facilitate the use of PPPs, but there exist no standards or best practices in the United States for procurement, concession terms, or risk-sharing.
Preface to the National Lawyer's Guild Review, 66-2

Introduces: 1. Call for the Rwandan Government to Drop Charges Against Prof. C. Peter Erlinder by Nathan Goetting; 2. Citizens United and the Fetishism of the Corporation by David Gespass; 3. Crime and Punishment in Private Prisons by Matthew Mulch; 4. U.S. War Crimes: Torture as Official Bush Administration Policy by Alan Clarke; 5. Testimony on Torture Policy before the House Subcommittee on the Constitution, Civil Rights and Civil Liberties, House Judiciary Committee by Marjorie Cohn; 6. Organizing -- With or Without the NLRB by Henry M. Willis; 7. Book Review: The Assassination of Fred Hampton by David Gespass.
Evaluation of the Effect of A Structured Program to Guide Residents’ Experience in Research (ASPIRE) on Pharmacy Residents’ Knowledge, Confidence, and Attitude toward Research

Study objective To evaluate the effect of A Structured Program to guide Resident Experience in Research (ASPIRE) on pharmacy residents' knowledge, confidence, and attitude toward research. Design Nonrandomized controlled study using data from a validated questionnaire administered through an online survey. Participants Of 60 pharmacy residents (residency year 2013-2014) who completed the baseline assessment, the 41 residents who also completed the follow-up assessment were included in the final analysis; of those, 26 Colorado pharmacy postgraduate year 1 (PGY1) and year 2 (PGY2) residents were enrolled in ASPIRE between July 2013 and June 2014 (intervention group) and 16 PGY1 and PGY2 pharmacy residents outside of Colorado did not participate in ASPIRE (control group). Measurements and main results Both the intervention and control groups completed a pre- and post-assessment at the beginning (July 2013 [baseline]) and end (May/June 2014 [follow-up]), respectively, of their residency year that measured knowledge (with a tool measuring biostatistics and research methodology knowledge), confidence, and attitude toward research. Research knowledge scores improved similarly from baseline to follow-up in the intervention and control groups: 11.8% and 11.3%, respectively (adjusted p=0.8). Research confidence improved significantly more in the intervention group, with a 48% increase in confidence score from before to after residency completion, compared with a 15% increase in the control group (adjusted p=0.002). Residents in both the intervention and control groups expressed positive attitudes toward pharmacist-conducted research, with 100% and 87% of intervention and control residents, respectively (adjusted p=0.970), agreeing that pharmacist-conducted research is essential to driving pharmacy practice and expanding the roles of pharmacists. Conclusion ASPIRE was not associated with greater research methodology knowledge but did significantly increase confidence in performing research.
A review of automatic selection methods for machine learning algorithms and hyper-parameter values

Machine learning studies automatic algorithms that improve themselves through experience. It is widely used for analyzing and extracting value from large biomedical data sets, or “big biomedical data,” advancing biomedical research, and improving healthcare. Before a machine learning model is trained, the user of a machine learning software tool typically must manually select a machine learning algorithm and set one or more model parameters termed hyper-parameters. The algorithm and hyper-parameter values used can greatly impact the resulting model’s performance, but their selection requires special expertise as well as many labor-intensive manual iterations. To make machine learning accessible to layman users with limited computing expertise, computer science researchers have proposed various automatic selection methods for algorithms and/or hyper-parameter values for a given supervised machine learning problem. This paper reviews these methods, identifies several of their limitations in the big biomedical data environment, and provides preliminary thoughts on how to address these limitations. These findings establish a foundation for future research on automatically selecting algorithms and hyper-parameter values for analyzing big biomedical data.
Nephrogenic Adenoma in Patients with Transitional Cell Carcinoma of the Bladder Receiving Intravesical Thiotepa

AbstractNephrogenic adenoma is a rare, benign lesion of the urothelium that generally occurs after open surgery or other bladder trauma. We present 2 recently treated patients with nephrogenic adenomas, both of whom had been treated previously with transurethral resection and intravesical thiotepa for histologically proved transitional cell carcinoma of the bladder. The occurrence of nephrogenic adenoma after transurethral resection alone is extremely rare and suggests a possible adjuvant role of the intravesical thiotepa. With the increasing use of such local chemotherapeutic agents, the incidence of nephrogenic adenoma in such patients may be increasing.
Differential Subordination of Harmonic Functions and Martingales

A fruitful analogy in harmonic analysis is the analogy between a conjugate harmonic function and a martingale transform. One idea that underlies both of these concepts is the idea of differential subordination. Our study of it here yields new information about harmonic functions and martingales, and their interaction.
Activation of Xenobiotics by Human Polymorphonuclear Leukocytes via Reactive Oxygen-Dependent Reactions

Reactive oxygen intermediates have become widely implicated in various pathologic states, chemical-induced tissue injury and chemical carcinogenesis (1–5). While much of the interest in the role of oxy-radicals in these processes has centered on the direct interaction of reactive oxygen metabolites with biomolecules, it is becoming increasingly apparent that molecular oxygen-derived oxidants can also participate in the metabolic activation of chemicals (6,7). It has been hypothesized that polymorphonuclear leukocytes (PMNs) may be a useful cellular model to study the interaction and possible activation of compounds by reactive oxygen species (Figure 1)(8,9). Resting PMNs release measurable quantities of superoxide \({{O}_{2}}\overline{.}\) ), hydrogen peroxide (H2O2) and hydroxyl radical (•OH), while activation of their redox metabolism by both particulate and soluble stimulants results in an increased rate in the generation of these molecular oxygen-derived oxidants (10,11). The utilization of H2O2 by the PMN enzyme myeloperoxidase (MPO) results in the formation of hypochlorous acid and an O2 metabolite or complex with singlet oxygen (1O2)-like reactivity (11). The data presented in this study demonstrate that bleomycin A2 and benzo[a]pyrene-7,8-dihydrodiol (BP-7,8-dihydrodiol) are activated to genotoxic derivatives as a result of their interaction with PMN-derived oxidants. Such an activation mechanism could provide an explanation as to how neoplasms often develop at sites of ongoing inflammation (12).
Concentrating solar thermoelectric generators with a peak efficiency of 7.4

Concentrating solar power normally employs mechanical heat engines and is thus only used in large-scale power plants; however, it is compatible with inexpensive thermal storage, enabling electricity dispatchability. Concentrating solar thermoelectric generators (STEGs) have the advantage of replacing the mechanical power block with a solid-state heat engine based on the Seebeck effect, simplifying the system. The highest reported efficiency of STEGs so far is 5.2%. Here, we report experimental measurements of STEGs with a peak efficiency of 9.6% at an optically concentrated normal solar irradiance of 211 kW m−2, and a system efficiency of 7.4% after considering optical concentration losses. The performance improvement is achieved by the use of segmented thermoelectric legs, a high-temperature spectrally selective solar absorber enabling stable vacuum operation with absorber temperatures up to 600 ∘C, and combining optical and thermal concentration. Our work suggests that concentrating STEGs have the potential to become a promising alternative solar energy technology. Solar thermoelectric generators are a promising technology for converting solar energy into electricity, however their efficiency has been limited to 5.2%. Kraemer et al. report a solar thermoelectric generator with an efficiency of 9.6%, resulting in 7.4% efficiency in a concentrating solar thermoelectric system.
NATO Involvement in Radio Frequency Radiation (RFR) Research and Health Safety

The North Atlantic Treaty Organization (NATO) has encouraged and supported scientific and operational assessment projects concerning effects of RFR on military personnel, ordinance, and fuel for nearly three decades. The need for assessment and harmonization of RFR safety-guidance continues today, as safety standards are updated throughout the world, and as new RFR systems come on line. The majority of RFR systems in use, and in development, are unique to military applications. The adoption of a scientifically acceptable and defensible standard for human exposure to RFR that is applicable across national boundaries is of significant importance to commanders and operators engaged in multinational exercises and operations. Rapidly expanding technologies require that systems hardware and operations are integrated and compatible within NATO.
Indicators of revenues and expenditures of state and local governments: a measurement model approach

Government fiscal officers, practitioners and policy makers constantly deal with uncertainties in revenue and expenditure projections. These uncertainties create difficulties in resource allocation decisions when significant deviations occur. Clearly, certain variables account for these uncertainties and knowing them prior to revenue and expenditure planning may minimize potentials for errors. This study seeks to determine the identities and reliability of these variables through the application of a measurement model to aggregate data under the formulation that certain variables create uncertainties and affect significantly both revenues and expenditures of state and local governments. The results reveal that inflation, population, unemployment rate, time, government bond rate, and real long-term debts per capita are the most reliable indicators of both revenues and expenditures.
Denial of Suicide Attempt Among Hospitalized Survivors of a Self-Inflicted Gunshot Wound

Objective:Evidence suggests that suicide attempts by self-inflicted gunshot wound (GSW) are underreported and may in turn affect disposition following hospitalization. This study aimed to evaluate ...
Variability of attention bias in socially anxious adolescents: differences in fixation duration toward adult and adolescent face stimuli

Prior research on attention bias in anxious youth, often utilising a visual dot probe task, has yielded inconsistent findings, which may be due to how bias is assessed and/or variability in the phenomenon. The present study utilises eye gaze tracking to assess attention bias in socially anxious adolescents, and explores several methodological and within-subject factors that may contribute to variability in attention bias. Attention bias to threat was measured in forty-two treatment-seeking adolescents (age 12-16 years) diagnosed with Social Anxiety Disorder. Bias scores toward emotional stimuli (vigilant attention) and bias scores away from emotional stimuli (avoidant attention) were explored. Bias scores changed between vigilance and avoidance within individuals and over the course of stimulus presentation. These differences were not associated with participant characteristics nor with self-reported social anxiety symptoms. However, clinician rated severity of social anxiety, explained a significant proportion of variance in the bias scores for adult, but not the adolescent, stimuli. Variability in attention bias among socially anxious adolescents is common and varies as a function of stimulus duration and type. Results may inform stimulus selection for future research.
Comments on Supercomputing as an Interdisciplinary Activity

I would like to discuss supercomputing as an interdisciplinary activity. It has always been true that computational science is a field that exploits the results of many others. Our computers are built by electrical engineers, usually produced by commercial companies. We use languages, compilers, and other software produced by computer scientists. So how is the situation changing? The answer lies primarily in the greatly increased pace of change and the greatly broadened scope of the disciplines and tools involved. It is no longer simply a matter of writing a program in some well-established language, debugging it, producing some results, and then writing papers about the results. First of all, we use hardware that is evolving very rapidly. Again two of the talks before mine have emphasized how true that is: we now exploit highly parallel computing, much more powerful vector computing, and combinations of the two. As the hardware progresses, we have to use still more powerful software, software that evolves while we use it.
Transferred Electron Amplifiers and Logic and Functional Devices

Transferred electron amplifiers were first developed by Thim et al. in 1965 [1], who used subcritically doped devices [n 0 L < (n 0 L) 1 ; see Section 4–1] to achieve microwave amplification. Since that time other types of transferred electron amplifiers have been developed with the output power up to several tenths of watts. Even higher output powers are possible.
Beyond the Leadership Double-Bind for Women:A Coordination View of Leadership Effectiveness

A large body of research suggests that gender norms inhibit women’s leadership effectiveness. Women’s efforts to navigate gender legitimize gender norm constraints, producing a leadership double-bi...
Identifying High-Performing Students in Inpatient Clerkships: A Qualitative Study.

Examine fundamental behaviors and characteristics that attending physicians in inpatient settings utilize to identify high-performing clerkship students. We employed written comment data from a cross-sectional survey of Internal Medicine and Pediatrics attending physicians at a single academic medical center in the southern USA. Free-text responses regarding factors that faculty consider when assigning honors grades were analyzed by four trained researchers (interrater agreement 0.87) using conventional content analysis to identify themes. Seventy-nine of 141 (56%) attending physicians who were surveyed provided 90 comments. Four major theme areas for recognizing higher performing clerkship students were identified: Taking Ownership of Patient Care (35%), Medical Knowledge and Clinical Reasoning (20%), Team Orientation (15%), and Awareness of Opportunities for Growth and Progress (13%). Internal Medicine and Pediatric attending physicians identified characteristics that contributed to four themes in the determination of a high-performing medical student. These findings are particularly salient, as they highlight that commitment to patients, application of clinical knowledge and skills, teamwork, and awareness of growth and progress are valued by attending physicians for identifying top performing students in inpatient settings.
Gradient-Based Propeller Optimization with Acoustic Constraints

Urban Air Mobility (UAM) vehicles are intended to operate near or within large cities, where a significant portion of the public will be exposed to the noise they create. If these vehicles are to become acceptable to the public, designers must be able to manage the amount of noise they generate, and understand the relationship between traditional performance metrics (thrust, efficiency, etc.) and noise. As a first step to addressing this need, this work combines a Blade Element Momentum Theory tool (OpenBEMT) with an acoustic prediction tool (ANOPP2) to optimize a propeller subject to both aerodynamic and acoustic constraints. These tools are developed within a optimization framework (OpenMDAO (Multidisciplinary Design Analysis Optimization)) that allows analytic derivatives to be propagated through the models and passed to a gradient-based optimizer. This tool chain is exercised on the cruise propellers from the X-57 Maxwell, and yields propeller designs that reduced the overall sound pressure level by about 8 decibels for a cost of 3 percent propeller efficiency.
Multiplicitous Moments: The Inculcation, Abstraction, and Resistance to the Face of the Novice Science Teacher

Lived experiences are multiple. Utilizing deleuzoguattarian concepts, the chapter examines the double articulation of becoming a researcher of science teacher induction and science teacher educator to critically examine the taken-for-granted norms of what it means ‘know’ the novice science teacher. The first articulation depicts four multiplicitous moments of sedimentation that occurred throughout the author’s doctoral education. The second articulation examines how those lived moments fold and re-fold into research on science teacher induction. Drawing heavily on Deleuze and Guattari, the author re-conceptualizes science teacher induction from conventional programs of support, socialization, and limited, predictable blocks of time to a process of signification referred to as facialization.
ENT Rank: Retrieving Entities for Topical Information Needs through Entity-Neighbor-Text Relations

Related work has demonstrated the helpfulness of utilizing information about entities in text retrieval; here we explore the converse: Utilizing information about text in entity retrieval. We model the relevance of Entity-Neighbor-Text (ENT) relations to derive a learning-to-rank-entities model. We focus on the task of retrieving (multiple) relevant entities in response to a topical information need such as "Zika fever". The ENT Rank model is designed to exploit semi-structured knowledge resources such as Wikipedia for entity retrieval. The ENT Rank model combines (1) established features of entity-relevance, with (2) information from neighboring entities (co-mentioned or mentioned-on-page) through (3) relevance scores of textual contexts through traditional retrieval models such as BM25 and RM3.
Biological characterization of dehydrated amniotic membrane allograft: Mechanisms of action and implications for wound care

There is a growing clinical demand in the wound care market to treat chronic wounds such as diabetic foot ulcers. Advanced cell and tissue-based products (CTPs) are often used to address challenging chronic wounds where healing has stalled. These products contain active biologics such as growth factors and cytokines as well as structural components that support and stimulate cell growth and assist in tissue regeneration. This study addresses the in vitro biologic effects of a clinically available dehydrated amniotic membrane allograft (DAMA). The broad mechanism of action results from DAMA's biologic composition that leads to stimulation of cell migration cell proliferation, and reduction of pro-inflammatory cytokines. Results show that DAMA possesses growth factors and cytokines such as EGF, FGF, PDGFs, VEGF, TGF-β, IL-8, and TIMPs 1 and 2. Furthermore, in vitro experiments demonstrate that DAMA stimulates cell proliferation, cell migration, secretion of collagen type I, and the reduction of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. This study findings are consistent with the clinical benefits previously published for DAMA and other CTPs in chronic wounds suggesting that the introduction of DAMA to non-healing, complex wounds helps to improve the wound milieu by providing essential structural components, cytokines, and growth factors to create an appropriate environment for wound healing.
Comparative genomic analysis of Vibrios yields insights into genes associated with virulence towards C. gigas larvae

Vibriosis has been implicated in major losses of larvae at shellfish hatcheries. However, the species of Vibrio responsible for disease in aquaculture settings and their associated virulence genes are often variable or undefined. Knowledge of the specific nature of these factors is essential to developing a better understanding of the environmental and biological conditions that lead to larvae mortality events in hatcheries. We tested the virulence of 51 Vibrio strains towards Pacific Oyster (Crassostreae gigas) larvae and sequenced draft genomes of 42 hatchery-associated vibrios to determine groups of orthologous genes associated with virulence and to determine the phylogenetic relationships among pathogens and non-pathogens of C. gigas larvae. V. coralliilyticus strains were the most prevalent pathogenic isolates. A phylogenetic logistic regression model identified over 500 protein-coding genes correlated with pathogenicity. Many of these genes had straightforward links to disease mechanisms, including predicted hemolysins, proteases, and multiple Type 3 Secretion System genes, while others appear to have possible indirect roles in pathogenesis and may be more important for general survival in the host environment. Multiple metabolism and nutrient acquisition genes were also identified to correlate with pathogenicity, highlighting specific features that may enable pathogen survival within C. gigas larvae. These findings have important implications on the range of pathogenic Vibrio spp. found in oyster-rearing environments and the genetic determinants of virulence in these populations.
SoWhiteMostlyMale Federal Procedural Rulemaking Committees

Of the 630 members of a specialized set of committees responsible for drafting the federal rules for civil and criminal litigation, 591 of them have been white. That’s 94% of the committee membership. Of that same group, 513—or 81%—have been white men. Decisionmaking bodies do better work when their members are diverse; these rulemaking committees are no exception. The Federal Rules of Practice and Procedure are not mere technical instructions, nor are they created by a neutral set of experts. To the contrary, the Rules embody normative judgments about what values trump others, and the rulemakers—while expert—are not disinterested actors. This essay examines racial and gender diversity across six different committees. The data tell a textured story of homogeneity, diversity, and power. Critically, the respective committees’ demographic compositions differ both historically and now. But there is one significant similarity across all committees: The Chief Justice can and should appoint a more diverse set of individuals to these committees, and the rulemaking committee members, the Judiciary, and the Bar should demand it.
Does Bowel Function Change After Colectomy for Colon Malignancy

Abstract Background Colon cancer patients often ask how surgery will affect bowel function. Current understanding is informed by conflicting data, making preoperative patient counseling difficult. We aimed to evaluate patient-reported bowel function changes after colectomy for colon malignancy. Material and methods This was a retrospective analysis of a prospectively collected institutional database from July 2015 to June 2019. The included patients underwent colectomy for adenocarcinoma of the colon, and completed the Colorectal Functional Outcome (COREFO) questionnaire at preoperative presentation and postoperative followup. Preoperative and postoperative scores were compared using paired t-tests. Multivariable analysis was performed using domains demonstrating statistical significance on bivariate analysis, assessing the factors that were associated with symptomatic bowel function. Results We identified 117 patients with a mean age of 64 ± 13 y. The median time between preoperative and postoperative questionnaire completion was 52 d (interquartile range 45-70). Bowel movement frequency increased significantly from a mean preoperative score of 9.72 to a mean postoperative score of 14.2 (P = 0.003). There were no significant differences in the remaining four domains of bowel function or global function. Multivariable analysis demonstrated higher likelihood of symptomatic postoperative frequency scores in male patients (OR 3.85, 95% CI 1.44-11.11, P = 0.007) and patients with symptomatic preoperative frequency (OR 5.56, 95% CI 1.62-19.02, P = 0.006). Conclusions Patient-reported bowel movement frequency worsens at postoperative follow-up after colectomy for colon cancer, while overall bowel function does not change. Men and patients with preoperative symptomatic frequency have an increased likelihood of reporting symptomatic postoperative frequency. These findings should guide more personalized and evidence-based preoperative patient counseling.
On a Conjecture of E. M. Stein on the Hilbert Transform on Vector Fields

Let $v$ be a smooth vector field on the plane, that is a map from the plane to the unit circle. The authors study sufficient conditions for the boundedness of the Hilbert transform $\textrm{H}_{v, \epsilon }f(x) := \text{p.v.}\int_{-\epsilon}^{\epsilon} f(x-yv(x))\;\frac{dy}y$ where $\epsilon$ is a suitably chosen parameter, determined by the smoothness properties of the vector field. Table of Contents: Overview of principal results; Besicovitch set and Carleson's theorem; The Lipschitz Kakeya maximal function; The $L^2$ estimate; Almost orthogonality between annuli. (MEMO/205/965)
Development and Implementation of a Phased Framework for Collecting the COVID-19 Virus Material at a Medical University

As national leaders in infectious disease outbreaks, the University of Nebraska Medical Center (UNMC) and its hospital partner Nebraska Medicine monitored and treated COVID-19 patients, starting with evacuees from Wuhan, China in February 2020 To document UNMC?s institutional response to the COVID-19 pandemic, and future outbreaks or pandemics, UNMC?s McGoogan Health Sciences Library Special Collections and Archives (SCA) Department faculty quickly established an archival collecting strategy to create a broad documentation package with multiple collecting phases The initial phase included a contemporaneous response for digital collecting, timeline creation, and community collecting, followed by later collecting of personal papers, artifacts, and oral histories from key players who are also front-line workers The combined collecting approach ensured early digital content preservation, captured public momentum, and provided the structure for longer-term collecting, after time for healing and relationship-building with prospective donors
Isoprostanes in wastewater as biomarkers of oxidative stress during COVID-19 pandemic.

Isoprostanes are the potential biomarkers of endogenous human metabolism and proven clinically to provide the quantitative measure of systematic oxidative injury. An ultra-performance liquid chromatography-tandem mass spectrometric analytical method capable of determining four biomarkers of oxidative stress (8-iso-PGF2α, 2,3-dinor-iPF2α-III, PGE2, and 5-iPF2α-VI) in wastewater was developed and validated. Isoprostanes were quantified in the range of 31.1-1270 ng/L in raw wastewater samples in two communities in western Kentucky and Tennessee during the first four months of the COVID-19 pandemic. Consistent detection of PGE2 and 5-iPF2α-VI in wastewater suggested that PGE2 and 5-iPF2α-VI can be a reliable biomarker of community oxidative anxiety. The higher 4-month average mass load of isoprostanes [(ranged from 22.9 mg/d/1000 people to 807 mg/d/1000 people] may be attributed to the elevated community level oxidative anxiety owing COVID-19 uncertainties. The average mass loads of PGE2 and 5-iPF2α-VI in a community were significantly increased (two-tailed p < 0.001) from the first month of COVID-19 pandemic to the second month; however, significantly decreased (two-tailed p < 0.001) in the third month. Wastewater-based-epidemiological determination of isoprostanes can be a near-real-time and cost-effective approach of a trend in community depression. This is the first report of the quantification of PGE2 and 5-iPF2α-VI in wastewater and estimation of the community level oxidative anxiety.
Design and Economic analysis of a Grid-tied PV system to power a small village

Output optimization, operational efficiency and network stability are the key features of grid-networks. This paper presents the design and simulation of photovoltaic (PV) systems connected to a grid of 9 MW for the village located at a geographical location of (17.25_N, 77.55_E) in India. This requires a photovoltaic array incorporated with the software package of SAM (Process Advisor Model). The results of these runs contribute to the final parameters for the 9 MW PV process. The 9-MW PV-system has 27,744 PV panels of 310 W each and 136 inverters of 6.1 kW rating. The cost of one kWh produced by our system to emphasize the economic efficiency and promising potential of the proposed system has been calculated and the investment costs have been efficiently reduced though incentives for Grid tied PV system.
Bone Marrow Lesions on Preoperative Magnetic Resonance Imaging Correlate With Outcomes Following Isolated Osteochondral Allograft Transplantation.

Purpose The purpose of this study was to investigate the role of preoperative bone marrow lesion (BML) size and location on (1) postoperative patient reported outcomes and (2) postoperative failure and time to failure after osteochondral allograft (OCA) transplantation. Methods Consecutive patients from 2 senior surgeons who underwent isolated OCA transplantation to the knee from 2009-2018 were identified for the case series. Preoperative magnetic resonance imaging (MRI) was evaluated for BMLs based on 2 classification systems (Welsch et al. and Costa-Paz et al.) by 2 independent graders. BMLs associated with minimum 1-year postoperative outcomes were evaluated, and the effect of BML classification on survivorship was investigated with Kaplan-Meier curves. Results The 77 patients who underwent isolated OCA transplantation (mean follow-up: 39.46 ± 22.67 months) and had preoperative MRIs were included. Within this cohort, 82% of patients demonstrated a BML. The preoperative Costa-Paz et al. classification was significantly positively correlated with the postoperative Visual Analog Scale, International Knee Documentation Committee and Veterans RAND 12-Item Health Survey raw scores for both graders (P Conclusion Preoperative subchondral BMLs were present in 82% of patients undergoing OCA transplantation. We found that more severe BMLs based on the Costa-Paz classification, with increasing involvement in the juxta-articular surface, were correlated with higher postoperative patient-reported functional outcomes after OCA. BMLs may be associated with an increase in graft failure, but their role in this remains unclear. Level of Evidence IV, Retrospective Case Series.
Abstract TMP36: Exogenous Oxytocin Confers Significant Neuroprotective Effects and Improves Recovery in Young and Aged Animals After Stroke

Introduction: Oxytocin (OXT) is a highly evolutionary conserved neuropeptide and an important modulator of inflammation in response to stressors such as ischemia. Recent studies have implicated OXT...
A High Performance 48-to-6 V Multi-Resonant Cascaded Series-Parallel (CaSP) Switched-Capacitor Converter

Switched-capacitor (SC) converter topologies can achieve high efficiency and high power density due to their efficient switch utilization and use of high energy density capacitors. The use of resonant inductors can further improve efficiency by enabling soft-charging and soft-switching operations. However, the number of components (switches and capacitors) increases proportionally with the conversion ratio, increasing circuit complexity and potentially reducing performance. Because of this, SC converters with multiple operating states per switching cycle are attractive for high-step down applications as they can achieve the same conversion ratio as two-phase SC converters with fewer components. This work proposes and explores a new multi-phase resonant cascaded series-parallel (CaSP) topology, comprising a cascaded 2-to-1 SC stage with a 4-to-1 series-parallel stage. A 48-to-6 V prototype design for data center applications was built and tested, and achieved 98.6% peak efficiency (98.1% including gate drive loss), 95.3% full-load efficiency (95.2% including gate drive loss) at 70 A output, and 2140 W/in3 power density by box volume.
Roles of ontology in automated process safety analysis

Abstract Process safety analysis is an information intensive task. Collecting all the necessary information from different sources is time consuming and error prone. Most of the information may already be available in some electronic formats. Sharing and reusing this process information can save significant time and effort. Using ontology can greatly enhance the communication and inter-operability among different systems. In this work, ontologies are designed for various kinds of process information and safety analysis results. PHASuite, an intelligent software system for performing automated process safety analysis, has been built based on these ontologies. Appropriate information sharing schemes have been proposed and implemented in PHASuite. It is found, based on several industrial case studies, that information sharing can greatly reduce time and errors associated with reentering information.
Elementary versus Secondary School Teachers Retraining to Teach Computer Science

AbstractOne means of ensuring that K-12 computer science teachers are knowledgeable about computer science and school curricular content is by “retraining” experienced teachers. This study examined aptitudes and attitudes of elementary and secondary teachers as predictors of success in two NSF-funded retraining projects. Results are discussed in terms of success measured by course exams, course projects, and course grades. Similarities and differences regarding elementary versus secondary teachers are considered.