cssi/SciSciGPT-SciSciNet huggingface dataset:
Multiple epitope specificity of monoclonal antibodies to a single synthetic peptide: use in the characterization of the GP IIb-IIIa binding domain of von Willebrand factor.

Monoclonal antibodies have been induced against the synthetic peptide with sequence Tyr-Glu-Val-Val-Thr-Gly-Ser-Pro-Arg-Gly-Asp-Ser-Gln-Ser-Ser. This peptide represents residues Glu1737-Ser1750 of the mature von Willebrand factor (vWF) subunit and contains the sequence Arg-Gly-Asp, thought to be important in mediating binding to the platelet receptor glycoprotein (GP) IIb-IIIa complex. Twelve antibodies were obtained, eight of which bound to native vWF as well as to the peptide immunogen insolubilized onto agarose beads. These antibodies defined at least three distinct epitopes, as demonstrated by antibody interaction with peptides having a single phenylalanine substitution at each position in the sequence. In particular, two antibodies bound to epitopes on vWF that included one or more of the three residues (arginine, glycine, aspartic acid) thought to be involved in binding to GP IIb-IIIa, whereas one antibody bound to an epitope that did not include any of those residues. Nevertheless, the three antibodies cross-reacted with each other, a finding explained by the fact that the corresponding epitopes had at least two residues in common, namely G1y1741 and Ser1742. In spite of the cross-reactivity for binding to vWF, only the two antibodies whose epitopes included residues in the Arg-Gly-Asp sequence inhibited vWF interaction with GP IIb-IIIa. The third antibody had no inhibitory effect even though it was bound to an epitope located at a distance of only few residues on the amino terminal side of Arg-Gly-Asp. These results demonstrate that monoclonal antibodies raised against a single synthetic peptide with sequence limited to fifteen residues may exhibit distinct epitope specificity and may be used to define functional domains in macromolecules with a high degree of resolution.
Elephant in the Parlor: Repeal of Stepup in Basis at Death

Under current law, gain arising on property held until death is never taxed. Heirs treat the property as if it were purchased for a price equal to its value at death. The heirs can consume the property even for wasteful consumption without either heir or decedent paying tax. The new basis at death also makes it impossible to maintain a viable tax on capital gains consumed during life. The proposal would require carryover for provable costs. The proposal would simplify recordkeeping by giving a zero basis for unknown costs and for inheritances from outside the family. Heirlooms and household effects would have no basis. Collections would have basis of two-thirds the sale price, except for items costing more than $500.The proposal is made as a part of the Shelf Project, a collaboration by tax professionals to develop and perfect proposals to help Congress when it needs to raise revenue. Shelf Project proposals are intended to raise revenue, defend the tax base, follow the money, and improve the rationality and efficiency of the tax system. The tax community can propose, follow, or edit proposals at http://www.taxshelf.org. A longer description of the Shelf Project can be found at ‘‘The Shelf Project: Revenue-Raising Projects That Defend the Tax Base,’’ Tax Notes, Dec. 10, 2007, p. 1077, Doc 2007-22632, 2007 TNT 238-37.Shelf Project proposals follow the format of a congressional tax committee report in explaining current law, what is wrong with it, and how to fix it.Copyright 2008 Calvin H. Johnson.
Community-Led Ethnobotanical Triage: Case study—Myaamia corn traditions

Rapid loss of indigenous ethnobotanical traditions has created a need to triage research efforts to preserve this traditional knowledge. A triage process, however, is best led by those who understand the cultural context of historical data and are keenly aware of the community’s pressing needs—the indigenous community itself. Non-community researchers can be involved by lending research skills and connections towards the community-established research goals. This study described a process by which two non-indigenous community researchers supported an indigenous, Myaamia (Miami) research scholar in triaging Myaamia ethnobotanical research priorities and in conducting a focused study on the highest priority plant according to that community: corn ( Zea mays L.). Data gathered regarding Myaamia corn traditions allowed the reconstruction of the traditional corn cultivation cycle. Description of traditional corn processing techniques, recipes, and identifying traditional corn varieties is helping the Myaamia community in their efforts to preserve cultural historical knowledge associated with planting of corn and in so doing revitalize Myaamia language and culture.
The Ashley treatment: two viewpoints.

The news about Ashley, a severely cognitively and developmentally delayed child whose parents chose to medically limit her physical size, grabbed the attention of all of us. What if this was my child? Would I want to make my child smaller so that she would always be able to be cared for in a home, by family members? Growth attenuation treatment for children such as Ashley challenges us to think beyond our initial reactions. Ashley has the developmental and cognitive capacity of a young infant (Gunther & Diekema, 2006). She cannot hold up her head, roll or otherwise change her body position. She moves her arms and legs but cannot sit unsupported. Ashley responds positively to music and is able to vocalize but cannot talk (Parent’s blog, 2006). She is alert to her environment but it is not clear that she recognizes people, including her own family. Ashley cries to express her frustration or discomfort. Currently, she lives at home with her parents and two siblings and is cared for by extended family. Ashley’s parents chose to attenuate Ashley’s growth – to make her smaller – through the use of high dose estrogen therapy. In addition, Ashley’s parents requested, and her physicians agreed, to remove her uterus and breast buds (Gunther & Diekema; Parents; 2006). These three choices were made for separate therapeutic reasons. Growth attenuation through high dose estrogen therapy hastens the normal impact of puberty on girls’ height. With puberty, estroIn Opposition of the Ashley Treatment Teresa A. Savage
Looking Upstream and Downstream in Entrepreneurial Cognition: Replicating and Extending the Busenitz and Barney (1997) Study

We revisit the assertion that entrepreneurs are uniquely characterized in their ways of thinking; specifically being relatively more prone to the overconfidence bias and the representativeness heuristic in their decision-making. We replicate an earlier seminal study in entrepreneurial cognition, with a wider and more current survey. We then extend that analysis by investigating whether such “different thinking” leads to different (i.e., less rational) choices and different (i.e., worse) firm performance. Given the expected differences, we also investigate whether there exist other factors that affect the use of such biases and heuristics, to control their effects on focal outcomes.
The Wilmot Proviso Revisited

IF any event in American history can be singled out as the beginning of a path which led almost inevitably to sectional controversy and civil war, it was the introduction of the Wilmot Proviso. The proposal of Pennsylvania's Democratic Congressman David Wilmot, that slavery be excluded from any territory the nation acquired from Mexico, threw the issue of slavery into the center of the political arena-a place it would retain for twenty years. Although historians have concurred on the importance of the Proviso, they have disagreed about the motivation and even the identity of its author. Such controversy surrounded the Proviso from the beginning. Within a month after its presentation, Jacob Brinkerhoff of Ohio claimed that he, not Wilmot, was the true author; he had selected Wilmot to introduce the measure because his own antislavery convictions were so well known that the speaker of the House would not give him the floor.' According to Brinkerhoff, a small group of antislavery Democrats was working on an amendment to the bill appropriating two million dollars for the negotiation of peace with Mexico when he presented his draft. The group agreed that Brinkerhoff's wording was the best, and Wilmot was asked to introduce the proposal.2 For many years, historians accepted Brinkerhoff's story and relegated Wilmot to the role of a front man for the antislavery group. In an influential article written in 1911, Clark E. Persinger attributed the Proviso to the
Traveler: a digital journal for enhancing learning and retention on field trips

The sketching trip is a time honored architectural tradition rooted in field-based observation and recording. To learn from great examples of the constructed environment and transmit those lessons to a project-based design studio, students are first asked to experience the spatial, social, and material dimensions and details of a place. The experiences gained by walking through cities and major sites are at the core of our educational approach. A dozen students enrolled in a field study follow their instructor around a corner and down a street, dutifully take photographs of a house designed by Frank Lloyd Wright, and then follow around a bend, up an avenue, and into a church yard to sketch a quaint and contemplative cloister. They'll do this all day long, and, yes, they will be learning. It is a core foundation for formal architecture education and remains a memorable learning experience for generations of students. As P.D. Smith writes, "The city needs to be explored at a walking pace and discovered step by step. For understanding a city is, indeed, a cumulative process not unlike turning the pages of a book" (2012, p. 169).
Effects of disulfide bond reduction on the excitatory and inhibitory postsynaptic responses of Aplysia ganglion cells.

Three kinds of the cholinoceptive neurons, nicotinic depolarizing (D)-, nicotinic hyperpolarizing (H)-, and muscarinic H-types, as well as two other kinds of neurons, GABA H-and dopamine H-types, were identified in Aplysia abdominal ganglion, and the effects of disulfide bond reduction and reoxidation on their postsynaptic responses were studied by measuring conductance change produced by each transmitter. The acetylcholine-induced responses of both nicotinic types (D-and H-) were depressed by reducing the disulfide bonds witn aitniotnreitol (DTT) and restored by reoxidizing with 5, 5'-dithiobis-(2-nitrobenzoic acid):(DTNB), whereas the responses of the muscarinic H-, GABA H-, and dopamine H-cells were not affected at all by either DTT or DTNB.In contrast to the results obtained from the electroplax, the cholinergic receptors in our preparation showed neither the activation by hexamethonium nor the augmentation of decamethonium-induced responses after reduction of disulfide bonds.In addition, our preparation did not demonstrate the long-lasting responses to bromoacetylcholine, which was often observed in the electroplax after reduction of S-S bonds.DTT-induced depression of the nicotinic responses was studied on the dose-response curves; the mode of receptor inhibition was rather comnlexed. being neither tvae of competitive nor non-competitive.We concluded that the disulfide bond is a crucial element in both types of nicotinic receptors (D and H), and that this bond is related to the activation process of the receptors regardless of their ionic specificities.
Thermodynamics, phase segregation, polymer morphology, and interface/interphases in polymer nanocomposites

This chapter attempts to summarize research focusing on the analysis of polymer interfaces and phase segregation, advances in the study of nanoparticles, and polymer thermodynamic solution behavior. Key research is presented from UV-Vis spectroscopy and static light-scattering studies of nanocomposite materials as a means to define the thermodynamic behavior of solutions. Findings from neutron reflectivity studies of interfaces and segregation behavior of polymer nanocomposites is also presented.
Study on Dissolution Characteristic of Condensate Polishing Treatment Mixed Bed Resin

Aiming at problem of varying degree of lixiviation of impurities when using condensate mixed acid positive resin and alkali negative resin in thermal power plant,this paper measures products and analyzes dissolution characteristics of immersed resin by processing immersion test for condensate polishing treatment mixed bed resin of common marks and forms.On the basis of the test,it aims at conducting daily use of condensate polishing treatment mixed bed resin for power plant.
More Usable V-EGI for Volumetric Dataset Registration

Enhancements to the Volume-based Extended Gaussian Image (V-EGI) registration are described. The first enhancement is the capability to recover positional difference (in additional to rotational difference) between volumetric datasets. The second, and most important, enhancement uses a multi-stage coarse-to-fine processing strategy to improve computational speed. That enhancement also incorporates an optimization scheme to enable the strategy to maintain accuracy. The third enhancement is a methodology that achieves a moderate degree of parallelism on current-generation multi-core CPUs. Results of application of these methodologies to multiple datassets are also presented.
Alterations of cytosolic calcium in LLC-PK1 cells induced by vasopressin and exogenous purines

The regulation of cytosolic calcium in LLC-PK1 cells by various agonists was characterized. Arginine vasopressin (AVP, 100 nM) rapidly increased cytosolic calcium (Caf) measured with fura-2 from a ...
A new dimension of the youth culture.

Focusing on 17 college students who experienced what they called “religious conversion,” the author explores the recent perplexing religious preoccupation among youth. He describes the onset of thi...
Ultrasonic Characterization of Cylindrical Porosity — A Model Study

Recently, the frequency dependent ultrasonic attenuation has been used to find the volume fraction and pore size of gas porosity in cast aluminum alloys [1,2]. The question arises as to whether these techniques can be adapted for the characterization of porosity in layered materials, such as graphite-epoxy composites. One major difference lies in the morphology of the pores: they are nearly spherical in the aluminum alloys whereas they are long, parallel and needle-like in graphite-epoxy [3]. Consequently, it is of considerable interest to adapt the techniques developed for porosity estimation in [1] for the study of a collection of needle-like pores which we model as cylindrical voids.
The Game Plan: Converting the Story into a Game

This chapter assists the reader in assembling all of the various game elements developed so far into a curricular game using a design document as a tool to do so. In the process, this chapter helps readers determine the genre, specify the core game mechanic, think through player configuration, design the game space, establish the scoring mechanism(s), and propose rules. As the reader engages in this process, he or she is encouraged to think about how each element impacts another and how together they contribute to the gaming experience.
Drain the lysosome: Development of the novel orally available autophagy inhibitor ROC-325

Although macroautophagy/autophagy is a key contributor to malignant pathogenesis and therapeutic resistance, there are few FDA-approved agents that significantly affect this pathway. We used medicinal chemistry strategies to develop ROC-325, an orally available novel inhibitor of lysosomal-mediated autophagy. Detailed in vitro and in vivo studies in preclinical models of renal cell carcinoma demonstrated that ROC-325 triggered the hallmark features of lysosomal autophagy inhibition, was very well tolerated, and exhibited significant superiority with respect to autophagy inhibition and anticancer activity over hydroxychloroquine. Our findings support the clinical investigation of the safety and preliminary efficacy of ROC-325 in patients with autophagy-dependent malignancies and other disorders where aberrant autophagy contributes to disease pathogenesis.
Brunelleschi: Wo schneiden sich Parallelen? (1420)

Zu den fruhesten mathematischen Entdeckungen der heraufdammernden Neuzeit gehort um 1420 die Zentralperspektive, die von dem Erbauer der Kuppel des Doms von Florenz gefunden wurde, Filippo Brunelleschi. Von nun an wird der Standpunkt des Betrachters in die Darstellung einbezogen. Diese Entdeckung hatte Wirkungen weit uber Architektur und Malerei hinaus. Es war die Geburtsstunde eines neuen Zweiges der Geometrie, der Projektiven Geometrie. Wir stellen die Gesetze der perspektivischen Darstellung vor, ihre Entstehung aus der Zentralprojektion, die Albrecht Durer sehr anschaulich beschrieben hat, und ihre Weiterentwicklung zur Projektiven Geometrie mit den Satzen von Desargues und Pascal und dem (viel spateren) Begriff des Projektiven Raums.
Perceptions of Students in an Event Management Program of Annotation Systems and Their Influence on Student Learning

Nota bene is a collaborative document annotation Web site on which students can read lecture notes and class material and ask or answer questions of other students online. Utilizing collaborative theories of learning and the technology acceptance model in this study, we examined use and perceptions of Web-based collaborative annotation software among event management students. A self-reported survey instrument was given to 206 event management students, and findings revealed significant relationships between learning climate and social interaction and between perceived ease of use and perceived usefulness. Perceived ease of use and perceived usefulness were also related to learning satisfaction. In addition, learning satisfaction was related to behavioral intentions to use Nota bene. Implications for educators are discussed.
A Heptacyclic Heptacycle: A Doubly Naphtho[b]thiophene Fused Borepin

The synthesis and characterization of a doubly naphtho[b]thiophene fused borepin is reported herein, and the properties are compared to smaller benzo[b]thiophene and thiophene fused borepins. The synthesis involved the preparation of a symmetrical disubstituted alkyne that was reduced to a Z-olefin. This was followed by borepin formation from the alkene directly by way of thieno dilithiation. The electronic properties are consistent with extended benzannulation of the smaller analogues, and the enhancement of the brickwork type stacking is apparent as planar aromatic wings are extended from the central borepin core.
DECISION MAKING IN RHEUMATOID ARTHRITIS: Determining Surgical Priorities

Consideration of the individual, his or her needs, and what he or she hopes to gain through surgery is of primary importance in determining a surgical plan for the rheumatoid patient. Nevertheless, procedures undertaken to save life or prevent neurologic demise must, of course, take precedence. Alleviation of pain and correction of disabling deformity take next priority. Many other considerations go into the formulation of the list of surgical priorities. A full understanding of these considerations and a well-integrated team approach to the rheumatoid patient provide the best chance for optimal outcome following surgery.
Type-2 Fuzzy Similarity in Partial Truth and Intuitionistic Reasoning

Representing and manipulating the vague concepts of partially true knowledge pose a major challenge to the development of machine intelligence. In particular, the issue of how to extract approximate facts from vague and partially true statements has received considerable attention in the field of fuzzy information processing. However, vagueness is often due to a lack of available information, making it impossible to satisfactorily evaluate membership. Atanassov (1996) demonstrated the feasibility of mapping intuitionistic fuzzy sets to historical fuzzy sets. Intuitionistic fuzzy sets are isomorphic to interval valued fuzzy sets, while interval valued fuzzy sets have been regarded as unique value among type-2 fuzzy sets. This study presents a theoretical method to represent and manipulate partially true knowledge. The proposed method is based on the measurement of similarity among type-2 fuzzy sets, which are used directly to handle rule uncertainty that type-1 fuzzy sets are unable to deal with. Moreover, the switching relationship between type-2 fuzzy sets and intuitionist fuzzy sets is defined axiomatically. Results of this study demonstrate the effectiveness of the proposed theoretical method in pattern recognition and reasoning with regard to medical diagnosis.
Oral Alpha, Beta, and Gamma HPV Types and Risk of Incident Esophageal Cancer

Background: Several studies have examined association between human papillomaviruses (HPV) and esophageal cancer, but results have been inconsistent. This is the first prospective study to investigate associations between α, β and γ HPV detection in the oral cavity and risk of esophageal cancer.Methods: We conducted a nested case-control study among 96,650 cancer-free participants in the American Cancer Society Cancer Prevention Cohort and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Incident esophageal cancer cases (n = 125) were identified during an average 3.9 years of follow-up. Three controls per case (n = 372) were selected and matched on age, sex, race/ethnicity, and time since mouthwash collection. α, β, and γ HPV DNA in oral samples were detected using a next-generation sequencing assay. Conditional logistic regression models were used to estimate OR and 95% confidence intervals (CIs), adjusting for smoking and alcohol consumption. Statistical significance was evaluated using permutation test.Results: Prevalence of oral α, β, and γ HPV was 18.4%, 64.8%, and 42.4% in cases and 14.3%, 55.1%, and 33.6% in controls, respectively. Oral HPV16 detection was not associated with esophageal cancer (OR = 0.54, 95% CI, 0.1-4.84) and none of the esophageal squamous cell carcinoma cases (n = 28) were HPV16 positive. Some oral HPV types were more common in cases than controls; however, none of the associations were statistically significant.Conclusions: Although HPVs in the oral cavity are very common, this study showed no evidence of association between oral HPVs and esophageal cancer.Impact: Oral HPVs may not contribute to risk of esophageal cancer. Cancer Epidemiol Biomarkers Prev; 27(10); 1168-75. ©2018 AACR.
A Mobile Game for Automatic Emotion-Labeling of Images

In this short paper, we describe challenges in the development of a mobile charades-style game for delivery of social training to children with autism spectrum disorder (ASD). Providing real-time feedback and adapting game difficulty in response to the child's performance necessitates the integration of emotion classifiers into the system. Due to the limited performance of existing emotion recognition platforms for children with ASD, we propose a novel technique to automatically extract emotion-labeled frames from video acquired from game sessions, which we hypothesize can be used to train new emotion classifiers to overcome these limitations. Our technique, which uses probability scores from three different classifiers and meta information from game sessions, correctly identified 83% of frames compared to a baseline of 51.6% from the best emotion classification API evaluated in this paper.
Great Lakes Resource Sharing Conference of 2018: An Intern’s Experience

Attending the Great Lakes Resource Sharing Conference (GLRSC) made me realize that we are unconsciously sharing information. When we communicate with each other, we are giving information even if i...
Risk Factors for Short- and Long-Term Outcomes in Children With STEC-HUS/D+ HUS: A Single-Center Experience:

Background. Hemolytic uremic syndrome (HUS) is one of the common causes for acute kidney injury in childhood. Objective. The goals of our study were to identify risk factors for short-term complications and long-term outcomes of chronic kidney disease (CKD) in Shiga toxin-producing Escherichia coli (STEC)-HUS and other diarrhea positive (D+) HUS. Methods. Retrospective chart review was obtained of 58 pediatric patients treated for STEC-HUS and other D+ HUS between February 2002 and January 2011. Results. Thirty-three patients (56.9%) required dialysis. Dialysis was more likely initiated if a patient was a female (P 10 g/dL (P = .009) at admission. Neurological complications developed only among 5 dialyzed patients (P 10 days (P = .0004), or HGB level >10 g/dL (P = .034) at admission. Conclusions. Children with STEC-HUS/D+ HUS who may need dialysis are identified by female gender, lower urine output, higher serum creatinine level, and higher HGB at admission. They are at higher risk developing central nervous system complications especially if they needed HD. Children requiring >10 days of dialysis are at risk for development of CKD.
Fabrication and tribological characterization of deformation-resistant nano-textured surfaces produced by two-photon lithography and atomic layer deposition

Abstract In this study, we demonstrated a novel strategy for fabricating deformation-resistant nano-textured surfaces. Ordered arrays of IP-DIP photoresist nanodots of various diameters were first fabricated using two-photon lithography. IP-DIP/Al2O3 core-shell nanostructures (CSNs) were then formed by conformally coating the nanodots with Al2O3 of different thicknesses via atomic layer deposition (ALD). The CSNs showed 85% lower coefficients of friction than the bare IP-DIP nanodots and exhibited minimal nanostructure deformation at contact pressures greater than 20 GPa. The IP-DIP/Al2O3 CSNs also have lower adhesion forces than the bare IP-DIP nanodots. The excellent deformation resistance and superior tribological properties of these CSNs demonstrate that the combination of two-photon lithography and ALD is a very promising solution to tribological issues in miniaturized systems.
Characteristics and Consequences of Family Support in Latino Dementia Care.

The purpose of this study is to explore variations in family support for Latino dementia caregivers and describe the role of the family in dementia caregiver stress processes. Content analysis is utilized with themes derived inductively from 16 in-depth interviews with Latino caregivers recruited in California from 2002 to 2004. Three types of family support are described: extensive (instrumental and emotional support from family, n = 3), limited (instrumental support from one family member, n = 7), and lacking (no support from family, n = 6). Most caregivers report limited support, high risk for burnout and distress, and that dementia-related neuropsychiatric symptoms are obstacles to family unity. Caregivers with extensive support report a larger family size, adaptable family members, help outside of the family, and formalized processes for spreading caregiving duties across multiple persons. Culturally competent interventions should take into consideration diversity in Latino dementia care by (a) providing psychoeducation on problem solving and communication skills to multiple family members, particularly with respect to the nature of dementia and neuropsychiatric symptoms, and by (b) assisting caregivers in managing family tensions — including, when appropriate, employing tactics to mobilize family support.
Strain relaxation of InGaN/GaN multi-quantum well light emitters via nanopatterning.

Strain in InGaN/GaN multiple-quantum well (MQW) light emitters was relaxed via nanopatterning using colloidal lithography and top-down plasma etching. Colloidal lithography was performed using Langmuir-Blodgett dip-coating of samples with silica particles (d = 170, 310, 690, 960 nm) and a Cl2/N2 inductively coupled plasma etch to produce nanorod structures. The InGaN/GaN MQW nanorods were characterized using X-ray diffraction (XRD) reciprocal space mapping to quantify the degree of relaxation. A peak relaxation of 32% was achieved for the smallest diameter features tested (120 nm after etching). Power-dependent photoluminescence at 13 K showed blue-shifted quantum well emission upon relaxation, which is attributed to reduction of the inherent piezoelectric field in the III-nitrides. Poisson-Schrodinger simulations of single well structures also predicted increasing spectral blueshift with strain relaxation, in agreement with experiments.
Self-Assembly of Partially Oxidized Pillar[5]arene into Fibrous Structures

Partial oxidation of the pillar[5]arene macrocycle with Fe(III) leads to the isolation of a fibrous purple solid with high porosity. Experimental and computational data indicate that the solid material is primarily composed of macrocycles in which two of the hydroquinone units have been oxidized to benzoquinone units. Self-assembly takes place through the formation of multiple quinhydrone charge-transfer complexes between hydroquinone and benzoquinone units on adjacent macrocycles, providing a rare example of self-assembly based on a pentagonal molecular symmetry.
Oxidation Kinetics of Palladium

The kinetics of oxidation of palladium is investigated in this study. The effects of temperature and pressure on the oxide growth of palladium are discussed. A study of the linear regime of palladium oxidation data is examined, and regression analysis is utilized to analyze the oxidation of palladium. Comparison of the oxidation kinetics of palladium is made with that of ruthenium, rhodium and silver.
Applying blue ocean strategy to hire and assimilate workers with disabilities into distribution centers

Abstract As consumers increasingly choose to make their purchases from the comfort of their own homes rather than to visit brick-and-mortar stores, the need for fast-moving fulfillment and distribution centers (DCs) is proliferating. The Amazon effect that is so significantly changing the way people shop is also associated with an acute shortage of blue-collar workers in the retail-distribution industry. Firms’ traditional responses to the scarcity of warehouse labor are to increase hourly wages and to integrate automation and robotic product-fulfillment technologies. We identify an innovative human-capital-management approach that provides a timely, alternative solution to this important business problem. We present anecdotal, descriptive overviews of firms that are implementing blue ocean strategy (BOS) to proactively hire and assimilate workers with disabilities into their DCs. We also identify effective practices for partnering with local disability-service agencies to ensure that proactively hiring warehouse workers with disabilities creates mutual value and improves productivity. Finally, we discuss corporate social responsibility and the social impact of successfully hiring and assimilating workers with disabilities, with the intent of encouraging firms in the retail-fulfillment industry to view the traditional business problem of hiring warehouse workers from a new and alternative perspective.
‘Some people treat you like an alien’: Understanding the female athlete experience of belonging on campus

College athletes across north America are often known on their respective college campuses for their athleticism, and spend a considerable amount of hours weekly engaging in their respective sport ...
Emotion dysregulation as a maintenance factor for posttraumatic stress symptoms: The role of anxiety sensitivity.

Objectives The current study tested whether emotion dysregulation, assessed by the Difficulties in Emotion Regulation Scale (DERS), would predict posttraumatic stress symptoms (PTSS) through anxiety sensitivity (AS). Alternate cognitive-affective mediators (i.e., distress tolerance and intolerance of uncertainty) were explored. Method A total of 259 trauma-exposed community members (ages averaging 37.39; evenly distributed by gender) from a larger clinical trial targeting suicide risk factors completed a clinical interview and self-report questionnaires at baseline, Week-3, and 1-month follow-up appointments. Results AS at Week 3 significantly mediated the relationship between initial emotion dysregulation and 1-month follow-up posttraumatic stress symptoms (PTSS) after controlling for condition and baseline symptoms (β = .07; standard error = 0.03; 95% confidence interval = [0.01, 0.14]). Effects held for one out of six emotion dysregulation subscales. Distress tolerance and intolerance of uncertainty were not significant mediators (ps > .05). Conclusions This study demonstrates that emotion dysregulation may confer maintenance of PTSS through AS. Findings highlight potentially malleable targets for interventions.
Mission Uncertain: What Communities Does the ICC Serve?

This book chapter addresses a particularly intractable challenge the ICC faces: the absence of a clear mission. Apart from general statements, the ICC’s founders made little effort to agree on a mission or goals for the Court. Instead, states, non-governmental organizations and international organizations engaged in complex negotiations involving divergent agendas and resulting in many compromises. The outcome is a Statute with significant ambiguities and little specificity about the institution’s purposes and priorities. Despite the absence of a clear mission, the ICC has made important contributions to the cause of justice, however conceived, as the chapters of this book attest. Nonetheless, as the Court’s supporters look to the future, it is important to inquire whether the absence of a clear institutional mission at the ICC hinders its effectiveness. This chapter argues that it does.
Divergent Mast Cell Responses Modulate Antiviral Immunity During Influenza Virus Infection

Influenza A virus (IAV) is a respiratory pathogen that infects millions of people each year. Both seasonal and pandemic strains of IAV are capable of causing severe respiratory disease with a high risk of respiratory failure and opportunistic secondary infection. A strong inflammatory cytokine response is a hallmark of severe IAV infection. The widespread tissue damage and edema in the lung during severe influenza is largely attributed to an overexuberant production of inflammatory cytokines and cell killing by resident and infiltrating leukocytes. Mast cells (MCs) are a sentinel hematopoietic cell type situated at mucosal sites, including the lung. Poised to react immediately upon detecting infection, MCs produce a vast array of immune modulating molecules, including inflammatory cytokines, chemokines, and proteases. As such, MCs have been implicated as a source of the immunopathology observed in severe influenza. However, a growing body of evidence indicates that MCs play an essential role not only in inducing an inflammatory response but in suppressing inflammation as well. MC-derived immune suppressive cytokines are essential to the resolution of a number of viral infections and other immune insults. Absence of MCs prolongs infection, exacerbates tissue damage, and contributes to dissemination of the pathogen to other tissues. Production of cytokines such as IL-10 and IL-6 by MCs is essential for mitigating the inflammation and tissue damage caused by innate and adaptive immune cells alike. The two opposing functions of MCs-one pro-inflammatory and one anti-inflammatory-distinguish MCs as master regulators of immunity at the site of infection. Amongst the first cells to respond to infection or injury, MCs persist for the duration of the infection, modulating the recruitment, activation, and eventual suppression of other immune cells. In this review, we will discuss the immune modulatory roles of MCs over the course of viral infection and propose that the immune suppressive mediators produced by MCs are vital to minimizing immunopathology during influenza infection.
Weighing In on the Controversy: Preoperative Imaging in Unicoronal Craniosynostosis Leads to Strategic Changes in Surgical Care.

BACKGROUND Clinical findings in children with unilateral coronal craniosynostosis are characteristic, and therefore clinicians have questioned the need for confirmatory imaging. Preoperative computed tomographic imaging is a powerful tool for diagnosing associated anomalies that can alter treatment management and surgical planning. The authors' aim was to determine whether and how routine preoperative imaging affected treatment management in unilateral coronal craniosynostosis patients within their institution. METHODS A retrospective, single-center review of all patients who underwent cranial vault remodeling for unilateral coronal craniosynostosis between 2006 and 2014 was performed. Patient data included demographics, age at computed tomographic scan, age at surgery, results of the radiographic evaluation, and modification of treatment following radiologic examination. RESULTS Of 194 patients diagnosed with single-suture craniosynostosis, 29 were diagnosed with unilateral coronal craniosynostosis. Additional radiographic anomalies were found in 19 unilateral coronal craniosynostosis patients (65.5 percent). These included severe deviation of the anterior superior sagittal sinus [n = 12 (41.4 percent)], Chiari I malformation [n = 1 (3.4 percent)], and benign external hydrocephalus [n = 2 (6.9 percent)]. The radiographic anomalies resulted in a change in management for 48.3 percent of patients. Specifically, alteration in frontal craniotomy design occurred in 12 patients (41.4 percent), and two patients (6.9 percent) required further radiographic studies. CONCLUSIONS Although clinical findings in children with unilateral coronal craniosynostosis are prototypical, preoperative computed tomographic imaging is still of great consequence and continues to play an important role in surgical management. Preoperative imaging enabled surgeons to alter surgical management and avoid inadvertent complications such as damage to a deviated superior sagittal sinus. Imaging findings of Chiari malformation and hydrocephalus also permitted judicious follow-up. CLINICAL QUESTIONS/LEVEL OF EVIDENCE Therapeutic, IV.
Economics of Product Development by Users: The Impact of 'Sticky' Local Information

Those who solve more of a given type of problem tend to get better at it — which suggests that problems of any given type should be brought to specialists for a solution. However, in this paper we argue that agency-related costs and information transfer costs (‘‘sticky’’ local information) will tend drive the locus of problem-solving in the opposite direction — away from problem-solving by specialist suppliers, and towards those who directly benefit from a solution and who have difficult-to-transfer local information about a particular application being solved, such as the direct users of a product or service. We examine the actual location of design activities in two fields in which custom products are produced by ‘‘mass-customization’’ methods: application-specific integrated circuits (ASICs) and computer telephony integration (CTI) systems. In both, we find that users rather than suppliers are the actual designers of the application-specific portion of the product types examined. We offer anecdotal evidence that the pattern of user-based customization we have documented in these two fields is in fact quite general, and we discuss implications for research and practice.
Performance of Three Asthma Predictive Tools in a Cohort of Infants Hospitalized With Severe Bronchiolitis

Childhood asthma develops in 30-40% of children with severe bronchiolitis but accurate prediction remains challenging. In a severe bronchiolitis cohort, we applied the Asthma Predictive Index (API), the modified Asthma Predictive Index (mAPI), and the Pediatric Asthma Risk Score (PARS) to predict asthma at age 5 years. We applied the API, mAPI, and PARS to the 17-center cohort of infants hospitalized with severe bronchiolitis during 2011-2014 (35th Multicenter Airway Research Collaboration, MARC-35). We used data from the first 3 years of life including parent interviews, chart review, and specific IgE testing to predict asthma at age 5 years, defined as parent report of clinician-diagnosed asthma. Among 875/921 (95%) children with outcome data, parent-reported asthma was 294/875 (34%). In MARC-35, a positive index/score for stringent and loose API, mAPI, and PARS were 24%, 68%, 6%, and 55%, respectively. The prediction tools’ AUCs (95%CI) ranged from 0.57 (95%CI 0.54-0.59) to 0.68 (95%CI 0.65-0.71). The positive likelihood ratios were lower in MARC-35 compared to the published results from the original cohorts. In this high-risk population of infants hospitalized with severe bronchiolitis, API, mAPI, and PARS had sub-optimal performance (AUC0.8) asthma prediction tools are desired in infants hospitalized with severe bronchiolitis.
UN peacekeeping in civil wars

1. Introduction 2. The failures: Somalia, Rwanda, Angola, Bosnia 3. Namibia: the first major success 4. El Salvador: centrally-propelled learning 5. Cambodia: organizational dysfunction, partial learning and mixed success 6. Mozambique: learning to create consent 7. Eastern Slavonia: institution-building and the limited use of force 8. East Timor: the UN as state 9. The ongoing multidimensional operations 10. Conclusion: two levels of organizational learning.
Change in offspring sex ratio over a very short season in Lincoln's Sparrows: the potential role of bill development

The sex ratios of offspring are targets of natural selection that can affect parental energy expenditure and fitness, adult sex ratios, and population dynamics. Parents may manipulate offspring sex ratios based on sex differences in potential reproductive success. In Lincoln’s Sparrows (Melospiza lincolnii), male bill shape is associated with the quality of songs, and song quality predicts female preferences in a reproductive context.Males and females that hatch later relative to brood mates or later in the breeding season tend to develop bill shapes that are, for males, associated with low-quality song. Because females do not sing and do not experience this selection pressure, we predicted that the sex of offspring produced late relative to their brood mates or relative to the season should be biased toward females. Using a molecular technique to sex nestlings, we found no effects of hatching order or any interaction between date of clutch initiation and hatching order on offspring sex. However, we found a seasonal decline in the proportion of male offspring, from approximately 0.8 at the beginning to 0.4 at the end of a clutch initiation season only 19 d in duration. To our knowledge, this is the shortest period over which the offspring sex ratio has been shown to change in a bird population. Moreover, these findings are consistent with the hypothesis that sex differences in the potential attractiveness of offspring ultimately influence offspring sex ratios.
New Keynesian Endogenous Stabilization in a Panel of Countries

In the new Keynesian model of endogenous stabilization governments have objectives with respect to macroeconomic performance, but are constrained by an augmented Phillips curve. We develop an econometric characterization of the political-economic equilibrium using the Kalman filter to model the unobserved natural rate. Applying this methodology to a panel of North Atlantic countries, we find it consistent with history with a few qualifications. For one, governments are more likely to target growth rates, than output gaps. And, inflation expectations are more likely adaptive, than rational. Also, the error restrictions implied by the standard inflation-productivity shocks formulation needs to be relaxed.
Developing the Dance Artist in Technique Class: The Alteration Task

ABSTRACT For intermediate and advanced university students, technique class has traditionally been the place to study a particular teacher's style and to hone technical skills. This article suggests a pedagogy that broadens standard practice by focusing additionally on both performance principles and spontaneous problem solving in the technique classroom. Developed as an integral part of her technique pedagogy, the author generates myriad Alteration Tasks that require her students' spontaneous decisions to alter well-learned modern dance phrases as they are dancing them. The benefits of this methodology in technique class include (a) empowering students, (b) incorporating critical thinking in dance technique class, and (c) focusing on specific and varied performance principles. This article outlines the Alteration Tasks, the pedagogical benefits, and practical recommendations for technique teachers.
THE FACTS OF COLONIAL MODERNITY AND THE STORY OF SIKHISM

Story and fact are always in uneasy tension with each other. No matter how carefully we line up the historical data or how honestly we report the actual events through which we have lived, these do not by themselves tell the story of our lives. To tell all is not to tell a tale. Getting the facts straight is not enough to find the story to which they belong. In fact, getting the facts straight is a very different activity from that of finding a story that can be ‘faithful’ to the facts. [Carse, James P. 1994. Breakfast at the Victory: The Mysticism of Ordinary Experience, 171–172. San Francisco, CA: HarperSanFrancisco.]
Abstract 174: In-vivo Assessment of the Impact of Regional Intracranial Atherosclerotic Lesions on Brain Arterial 3D Hemodynamics

Purpose: To evaluate the feasibility of 4D flow MRI for the in-vivo assessment of the impact of regional stenotic lesions on intracranial arterial hemodynamics in patients with intracranial atherosclerotic disease (ICAD). Method: 4D flow MRI data were acquired in 23 ICAD patients (13 male, 67±14 years) and 8 healthy volunteers (4 male, 60±11 years). The stenosed vessels were internal carotid artery (ICA, n=8), middle cerebral artery (MCA, n=11), and basilar artery (BA, n=7). 3D blood flow characteristics were visualized using time-integrated pathlines (Fig. 1a-c). Blood flow and peak velocity in the major intracranial arteries (ICA, MCA, PCA, and ACA) were quantified in manually positioned 2D planes (Fig. 1a). Asymmetry index (affected/non-affected for patients or left/right ratios for volunteers) of the blood flow (AI-F) and peak velocity (AI-V) were compared between patients and volunteers for the above 4 vessels. Results: The following indices were significantly different between volunteers and patients with ICA and MCA stenosis (Fig. 1d, e). For patients with ICA stenosis compared to volunteers, the indices measured for ICA location were: AI-F (0.48±0.23 vs. 0.99±0.05, P Conclusion: Our findings demonstrated the feasibility of 4D flow MRI to quantify the impact of a regional stenotic lesion on changes in other intracranial arterial hemodynamics. Quantitative hemodynamic markers may provide additional insight into the pathophysiology and risk stratification for ICAD patients.
American Association of Clinical Psychologists (AACP)

The American Association of Clinical Psychologists (AACP) was founded in 1917 and lasted only 2 years. It was incorporated into the American Psychological Association in 1919 as the Clinical Section. Its founder was Leta Hollingworth (1886–1939), a prominent feminist and later a professor at Teachers College of Columbia University. Its membership included many of the first generation of clinical psychologists. Keywords: child development; clinical neuropsychology; developmental disorders; abnormal; assessment
The political costs of tax increases and expenditure reductions: Evidence from state legislative turnover

This paper estimates the political costs of increasing taxes and cutting expenditures for members of a legislature. It is found that both costs are individually significant, but that they are not significantly different. This coincides with the first order condition for maximization of the probability of reelection. Republican legislatures have a higher political cost for taxes, thus the party's relative bias toward smaller government is founded in stronger constituent preferences against taxes, not for lower spending. Additionally, by being ideologically conservative, Republicans lower the political costs of taxes, while by being more liberal, Democrats lower the cost of cutting expenditures.