cssi/SciSciGPT-SciSciNet huggingface dataset:
Concurrent protracted febrile myalgia syndrome in a child with diabetic ketoacidosis

Familial Mediterranean Fever (FMF), characterized by recurrent attacks of inflammation in predominantly serosal and synovial membranes, is caused by MEFV gene mutations resulting in abnormal pyrin. Protracted febrile myalgia syndrome (PFMS), a kind of vasculitis requiring corticosteroid treatment, is associated with M694V mutation of MEFV gene. Here, we report a case where the patient developed PFMS leading to the diagnosis of FMF concurrently at the time of treatment for diabetic ketoacidosis (DKA) of new-onset type 1 diabetes mellitus and discuss the possible mechanisms of simultaneous DKA and FMF-associated PFMS. DKA-associated cytokine release may be a predisposing factor or trigger for FMF-associated PFMS.
Radiative equilibrium model of Titan's atmosphere

The present global radiative equilibrium model for the Saturn satellite Titan is restricted to the two-stream approximation, is vertically homogeneous in its scattering properties, and is spectrally divided into one thermal and two solar channels. Between 13 and 33% of the total incident solar radiation is absorbed at the planetary surface, and the 30-60 ratio of violet to thermal IR absorption cross sections in the stratosphere leads to the large temperature inversion observed there. The spectrally integrated mass absorption coefficient at thermal wavelengths is approximately constant throughout the stratosphere, and approximately linear with pressure in the troposphere, implying the presence of a uniformly mixed aerosol in the stratosphere. There also appear to be two regions of enhanced opacity near 30 and 500 mbar.
Recent advances in molecular dynamics simulation towards the realistic representation of biomolecules in solution

Coupled advances in empirical force fields and classical molecular dynamics simulation methodologies, combined with the availability of faster computers, has lead to significant progress towards accurately representing the structure and dynamics of biomolecular systems, such as proteins, nucleic acids, and lipids in their native environments. Thanks to these advances, simulation results are moving beyond merely evaluating force fields, displaying expected structural fluctuations, or demonstrating low root-mean-squared deviations from experimental structures and now provide believable structural insight into a variety of processes such as the stabilization of A-DNA in mixed water and ethanol solution or reversible β-peptide folding in methanol. The purpose of this overview is to take stock of these recent advances in biomolecular simulation and point out some common deficiencies exposed in longer simulations. The most significant methodological advances relate to the development of fast methods to properly treat long-range electrostatic interactions, and in this regard the fast Ewald methods are becoming the de facto standard.
Events associated power system oscillations observation based on distribution-level phasor measurements

Power systems are continuously exposed to various disturbances, such as generation trip, line trip, etc. These variations may initiate oscillations that could jeopardize the system stability if not well damped. The distribution-level phasor monitoring system provides a low cost solution to collect the frequency, phase angle, and voltage magnitude data during the oscillations. By monitoring these parameters, the dynamic behavior of a system could be observed. In this paper, some sample oscillation cases, excited by different types of disturbances, are presented and analyzed using matrix pencil method. The oscillation characteristics could provide benchmarks for power grid's operating performance that helps with the future damping control strategy design.
Trichinella spiralis: Quantitative relationships between intestinal worm burden, worm rejection, and the measurement of intestinal immunity in inbred mice

Abstract The effect of widely different doses of Trichinella spiralis muscle larvae on time to rejection of intestinal adults and on host survival was assessed in mice of the three rejection phenotypes; strong, intermediate, and weak. Rejection is weak with doses of less than 50 larvae per mouse. At these doses all mice rejected worms at a similar rate and no phenotypic variation was evident among strains. In contrast, rejection time was shortest for all strains and phenotypic variation among strains was evident in the range 50–100 muscle larvae/mouse. Above this dose the time taken to rejection increases monotonically with dose for all mouse strains examined. Despite this, the relative strength of rejection (i.e., phenotype) of a given strain of mouse was not changed at higher doses. Based on an end point of 98% rejection of the infective dose, time to rejection was predictable to ± 1 day for all mouse strains and doses tested over the range 100–1000 worms administered. The principal reason for the increased time to complete rejection with larger worm doses was a delay in the initiation of intestinal rejection. This delay was evident above a dose of 50–100 larvae per mouse and occurred in all strains. Once begun, rejection was faster and eliminated more worms in unit time at higher doses (400–800 more) than at lower doses of worms. This appeared to be due to a stronger immune response of the host at higher doses. However, the increase in the rate of rejection was still not as great as the increase in the dose. We postulate that the delay in rejection with increased dose is due to a requirement for a “critical mass” of effectors/worm required to cause rejection. As dose increases, more time is required to reach the level at which worm rejection commences. Deaths due to higher doses of worms also occurred in a strain specific manner and were temporally biphasic. The intestinal phase of infection produced mortality from 1 to 5 days after infection and the strongest rejection phenotype (NFS) was also the most resistant to intestinal deaths. Deaths occurring after Day 5 were due to the parenterally migrating newborn larvae. The weakest rejection phenotype, that of the B10 congenics, was also the least resistant to intestinal deaths. An experimental formula describing 98% worm rejection time with different doses was derived from the data. Simple dynamical system theory was used to explain several experimental observations relating dose to rejection time. The mathematical analysis and the experimental observations do not support selective dose-dependent immunosuppression of worm rejection.
Research by Retailers: Understanding Loss and the Effectiveness of Loss Prevention Strategies

Many retail companies may conduct research on various aspects of retail theft or loss prevention but because of the proprietary nature of this research, it may not be reported in academic or trade journals. As a result, we know little about the focus or analytical techniques retailers use to conduct research. The data for this study were collected from a diverse group of retail companies. The study examines retailers' conduct to better understand theft in their stores and technologies to reduce theft. The findings indicate that retailers use a variety of analytical techniques to study retail loss and loss prevention, and are more likely to conduct research to understand the nature of loss when they believe that they have a severe loss problem. A substantially higher percentage of companies conduct research on loss prevention technologies than they do on understanding the sources of loss.
Biaxial long-stemmed multipronged distal components for revision/bone deficit total-wrist arthroplasty

Revision total-wrist arthroplasty has a high incidence of complications. Loosening is a significant problem for the distal implant. Because of the high failure rate of single-pronged distal implants after revision total-wrist arthroplasty, a custom multipronged distal component (biaxial total-wrist implant) was designed for use in patients with deficient bone stock who undergo revision operation. Ten cases of total-wrist arthroplasty with a custom long-stemmed multipronged distal component are presented. The preoperative diagnosis was failed total-wrist arthroplasty in 9 cases. Mean time from previous total-wrist arthroplasty to revision procedure was 5.6 years. At follow-up evaluation (mean, 3.8 years; range, 3.0–4.8 years), 2 patients had undergone arthrodesis: 1 patient at an outside institution 1 year after surgery for periprosthetic fracture of the radius, and 1 patient at our institution for distal implant loosening. The 8 other patients had functional total-wrist arthroplasties. At follow-up evaluation, all patients reported they were satisfied. Six patients reported no pain and 2 reported mild pain. Mean range of motion at follow-up evaluation was within the previously defined limits that allow patients to function in activities of daily living: 78° for supination, 77° for pronation, 39° for extension, 17° for flexion, 12° for radial deviation, and 18° for ulnar deviation. Revision total-wrist arthroplasty with custom long-stemmed, multipronged distal components offers an alternative to those patients with deficient bone stock who refuse arthrodesis. Early results demonstrate greater longevity compared with single-pronged components for revision total-wrist arthroplasty.
Casual recollections of an editor

The first issue of Papers on Non-Market Decision-Making is dated 1966 but I actually began work on it some time before publication. I should, perhaps, confess that it wasn't much work, but the little work that was involved did get spread over some time. I have resigned as editor and been formally installed in a state of great prestige and little power as Founding Editor as of the first of May 1990. My influence, however, by way of a backlog of accepted articles, will extend into 1991. I think, therefore, I can claim 25 years as editor. I can't say that it's been a hard grind on the whole, I enjoyed it. It's perhaps been a hard grind for people who wanted to publish articles in my journal and found that I was obstructive. I don't think that I had better advise people on editing since, in the first place, my editing methods are radically different than those used for other journals. Secondly, I tried two other journals, one of which Frontiers in Economics had to be closed down after three issues, and the other, The Journal of Economic Criticism only made one. I have one hit out of three tries. Aspiring editors or founders of new journals would be better advised to follow the routine rather than my deviant procedures. Nonetheless, I propose to devote this article to recollections of my editorship.
WIND STRESS AND ELFIN STATURE IN A MONTANE RAIN FOREST TREE: AN ADAPTIVE EXPLANATION

Physiognomic trends in a population of Didymopanax pittieri Marchal (Araliaceae), a dominant shade-intolerant tree of the elfin forests of Costa Rica, are related to a gradient of wind stress. Wind stress in this forest increases with proximity to ridgecrests. For a given tree height, trunk girth increases with proximity to the ridgecrest. At the same time twig slenderness decreases. These responses are produced in part by slower elongation of twigs which are exposed to stronger winds. These trends suggest that elfin stature is an adaptive response to greater wind stress along exposed ridges.
The cytoskeleton: I-beams of the cell

Cells derive their structural properties from a complex and active arrangement of stiff polymers. How those proteins interact to give rise to the cell’s diverse characteristics remains a key problem in biological physics.
Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer

Specialized nucleoprotein structures, termed telomeres, cap the ends of human chromosomes. These terminal structures, composed of repetitive arrays of guanine-rich hexameric DNA together with specific telomere-binding proteins, play essential roles in protecting the chromosome from damage and degradation. In addition, several lines of evidence implicate telomere maintenance as an important regulator of cell life span. Activation of telomerase, a dedicated reverse transcriptase that synthesizes telomeric sequences, is strongly associated with cancer, and recent observations confirm that telomeres and telomerase perform important roles in both suppressing and facilitating malignant transformation. These dual functions of telomere biology are evident in the clinical manifestations of the multisystem syndrome, dyskeratosis congenita, forms of which display defects in telomerase function. Recent advances in our understanding of telomere biology indicate that the manipulation of telomeres and telomerase will lead to clinically significant applications in the diagnosis, prevention, and treatment of neoplastic disease.
Logical analysis of diffuse large B-cell lymphomas

Objective:: The goal of this study is to re-examine the oligonucleotide microarray dataset of Shipp et al. (www.genome.wi.mit.du/MPR/lymphoma), which contains the intensity levels of 6817 genes of 58 patients with diffuse large B-cell lymphoma (DLBCL) and 19 with follicular lymphoma (FL), by means of the combinatorics, optimisation, and logic-based methodology of logical analysis of data (LAD). The motivations for this new analysis included the previously demonstrated capabilities of LAD and its expected potential (1) to identify different informative genes than those discovered by conventional statistical methods, (2) to identify combinations of gene expression levels capable of characterizing different types of lymphoma, and (3) to assemble collections of such combinations that if considered jointly are capable of accurately distinguishing different types of lymphoma. Methods and materials:: The central concept of LAD is a pattern or combinatorial biomarker, a concept that resembles a rule as used in decision tree methods. LAD is able to exhaustively generate the collection of all those patterns which satisfy certain quality constraints, through a systematic combinatorial process guided by clear optimization criteria. Then, based on a set covering approach, LAD aggregates the collection of patterns into classification models. In addition, LAD is able to use the information provided by large collections of patterns in order to extract subsets of variables, which collectively are able to distinguish between different types of disease. Results:: For the differential diagnosis of DLBCL versus FL, a model based on eight significant genes is constructed and shown to have a sensitivity of 94.7% and a specificity of 100% on the test set. For the prognosis of good versus poor outcome among the DLBCL patients, a model is constructed on another set consisting also of eight significant genes, and shown to have a sensitivity of 87.5% and a specificity of 90% on the test set. The genes selected by LAD also work well as a basis for other kinds of statistical analysis, indicating their robustness. Conclusion:: These two models exhibit accuracies that compare favorably to those in the original study. In addition, the current study also provides a ranking by importance of the genes in the selected significant subsets as well as a library of dozens of combinatorial biomarkers (i.e. pairs or triplets of genes) that can serve as a source of mathematically generated, statistically significant research hypotheses in need of biological explanation.
Lewis Wannamaker in the Campaign against Rheumatic Fever

Sur la valeur historique du premier travail de Wannamaker sur le rhumatisme articulaire aigu
Na+, Li+, and Cl- transport by brush border membranes from rabbit jejunum.

Na+, Li+, K+, Rb+, Br-, Cl- and SO4(2-) transport were studied in brush border membrane vesicles isolated from rabbit jejunum. Li+ uptakes were measured by flameless atomic absorption spectroscopy, and all others were measured using isotopic flux and liquid scintillation counting. All uptakes were performed with a rapid filtration procedure. A method is presented for separating various components of ion uptake: 1) passive diffusion, 2) mediated transport and 3) binding. It was concluded that a Na+/H+ exchange mechanism exists in the jejunal brush border. The exchanger was inhibited with 300 microM amiloride or harmaline. The kinetic parameters for sodium transport by this mechanism depend on the pH of the intravesicular solution. The application of a pH gradient (pHin = 5.5, pHout = 7.5) causes an increase in Jmax (50 to 125 pmol/mg protein . sec) with no change in Kt (congruent to 4.5 nM). Competition experiments show that other monovalent cations, e.g. Li+ and NH4+, share the Na+/H+ exchanger. This was confirmed with direct measurements of Li+ uptakes. Saturable uptake mechanisms were also observed for K+, Rb+ and SO4(2-), but not for Br-. The Jmax for K+ and Rb+ are similar to the Jmax for Na+, suggesting that they may share a transporter. The SO4(2-) system appears to be a Na+/SO4(2-) cotransport system. There does not appear to be either a Cl-/OH- transport mechanism of the type observed in ileum or a specific Na+/Cl- symporter.
Proof that all Dynamic Universal Solutions are Quasi-Equilibrated

This paper gives some necessary conditions for static or dynamic universal solutions of compressible or incompressible simple bodies. In particular, it is proved that all dynamic universal solutions are quasi-equilibrated. In der vorliegenden Arbeit werden notwendige Bedingungen fur statische oder dynamische universelle Losungen der Theorie einfacher kompressibler oder inkompressibler Korper angegeben. Insbesondere wird bewiesen, das alle dynamischen universellen Losungen Quasi-Gleichgewichtslosungen sind.
Analysis of honeydew melon (Cucumis melo var. inodorus) flavour and GC–MS/MS identification of (E,Z)‐2,6‐nonadienyl acetate

Although melon aromas have been extensively analysed, to our knowledge no GC–O investigations have been published on honeydew melon. An aroma extract of honeydew melon (Cucumis melo var. inodorus) was obtained by hydrodistillation under vacuum followed by solid-phase extraction, and analysed by GC–MS/O and GC–MS. Forty-two volatiles were positively identified, seven of which are reported for the first time in melon. The major volatiles were mostly saturated and unsaturated C9 alcohols and aldehydes. The levels of the corresponding acetates were too low to be detected by classical GC–MS analysis. However, using a sensitive and selective GC–MS/MS method, (E,Z)-2,6-nonadienyl acetate was identified for the first time in melon. Aroma extract dilution analysis (AEDA) of the extract revealed that (E,Z)-2,6-nonadienal was the most impactful compound of honeydew melon. AEDA results also showed that (Z,Z)-3,6-nonadien-1-ol and phenylethyl alcohol imparted fresh and sweet-floral characters, respectively, to honeydew aroma. Copyright © 2009 John Wiley & Sons, Ltd.
Describing Latinos Families and Their Help-Seeking Attitudes: Challenging the Family Therapy Literature

Latinos comprise a diverse ethnic group in the United States, yet central concepts describing Latinos persist. The purpose of this study was to assess the degree to which Latinos agree with the statements found in the marriage and family therapy (MFT) literature used to describe Latinos and Latino families, as well as their help-seeking attitudes and experiences. Research questions were derived from five constructs used to describe Latinos: familism, personalism, sense of hierarchy, spiritualism, and fatalism (Ho in Family therapy with ethnic minorities. Sage, Newbury, CA, 1987; Ho et al. in Family therapy with ethnic minorities, (2nd ed.). Sage, Thousand Oaks, CA, 2004). Overall, participants agreed with most of the statements pertaining to familism and personalism. However, mixed results were found for the constructs related to sense of hierarchy, spiritualism, and fatalism, as well as for participants’ help-seeking attitudes and behaviors. Latinos in this sample sought mental health professionals. However, MFTs were not sought as frequently as psychiatrists, psychologists, and clergy.
New paradigms and tools in drug design for pain and addiction.

New modalities providing safe and effective treatment of pain, especially prolonged pathological pain, have not appeared despite much effort. In this mini-review/overview we suggest that new paradigms of drug design are required to counter the underlying changes that occur in the nervous system that may elicit chronic pain states. We illustrate this approach with the example of designing, in a single ligand, molecules that have agonist activity at μ and σ opioid receptors and antagonist activities at cholecystokinin (CCK) receptors. Our findings thus far provide evidence in support of this new approach to drug design. We also report on a new biophysical method, plasmon waveguide resonance (PWR) spectroscopy, which can provide new insights into information transduction in g-protein coupled receptors (GPCRs) as illustrated by the δ opioid receptor.
Neuromuscular mechanisms of jaw and tongue movement

The masticatory process has a complex physiological background. Particular at­ tention has been given to the neurophysiological characteristics of this proc­ ess. Most of the studies on neuromuscular mechanisms have been concerned with limb muscles. However, there are distinct differences between jaw movements and limb movements. The mandibular joints are bilateral joints that function simul­ taneously. Movements of the jaw are varied and complex, being influenced by the anatomy of the teeth. Most of the jaw muscles are innervated by the trigem­ inal nerve. The nuclei of this nerve are widely distributed. They are found in the midbrain, pons, bulb and rostral spinal cord. T he descending neural pathways from the higher brain centers are not al­ ways similar to those of the limb muscles. This suggests that there exists a separate neural system for the jaw and tongue. The purpose of this article is to re­ view briefly the present physiological con­ cepts of the mechanisms of jaw and tongue movements. JA W M O V EM EN T AND FU N C T IO N O F JA W M U SC L E S
Stress-induced vortex line helixing avalanches in the plastic flow of a smectic A liquid crystal

Dynamic surface force measurements of the response of a smectic A to layer normal stress exhibited time dependence for topological events in which single smectic layers were added or removed. Single layer-sized jumps in sample thickness had a rapid component of duration of ∼1 second that produced most of the change in separation, but that was heralded by a slow precursor acceleration in separation, which began up to a few hundred seconds before. This avalanche-like dynamic signature is consistent with a relaxation mechanism based on the Glaberson-Clem-Bourdon instability of vortex lines (screw dislocations) in the smectic order parameter.
Nasal foreign body removal

Patients with nasal foreign bodies often present to the Emergency Department (ED) for removal. In most cases, successful removal can be performed by the Emergency Physician (EP) using a variety of simple techniques. The EP should be familiar with multiple procedural techniques as a significant number of patients will require multiple attempts and techniques for removal of the nasal foreign body. This article reviews the more common techniques for removal, and provides specific technical tips, indications and contraindications for each technique.
Effect of systemic medications on onset and progression of diabetic retinopathy

Diabetic retinopathy remains a leading cause of visual loss worldwide. Patients with diabetes mellitus commonly have multiple comorbidities treated with a wide variety of medications. Systemic medications that target glycemic control and coexisting conditions may have beneficial or deleterious effects on the onset or progression of diabetic retinopathy. In addition, data is accumulating to suggest that the use of systemic therapy primarily to address ocular complications of diabetic retinopathy may be a promising therapeutic approach. This article reviews our current understanding of the ocular-specific effects of systemic medications commonly used by patients with diabetes mellitus, including those directed at control of hyperglycemia, dyslipidemia, hypertension, cardiac disease, anemia, inflammation and cancer. Current clinical evidence is strongest for the use of angiotensin-converting enzyme inhibitors and angiotensin-2 receptor blockers in preventing the onset or slowing the progression of early diabetic retinopathy. To a more limited extent, evidence of a benefit of fibrates for diabetic macular edema exists. Numerous other agents hold considerable promise or potential risk. Thus, these compounds must undergo further rigorous study to determine the actual clinical efficacy and adverse effects before definitive therapeutic care recommendations can be offered.
Incorporating parameter variability in multi-attribute evaluation

Abstract Most decision situations in business, manufacturing and service industries represent problems with multiple alternatives where more than one objective needs to be considered in evaluating mutually exclusive strategies. A variety of approaches have been proposed and employed for evaluating such multi-attribute problems. These approaches generally utilize single point or most likely estimates in the evaluation process. This paper addresses the problem of developing a probabilistic additive weighting methodology which facilitates the inclusion of variability in the evaluation procedure.
The Role of Habit Strength in Social Network Game Play

This study tests assumptions that media consumption is, for the most part, automatic behavior. A regression model examining predictors of time spent playing social network games indicates that habit strength, not conscious motivations, is the most salient and significant predictor. Furthermore, specific features of game play that require repetitive activities contribute to habit. The results were consistent with literature in automaticity, and suggest that habit be included in future studies exploring online media use.
Carbon monoxide binding by de novo heme proteins derived from designed combinatorial libraries.

Carbon monoxide binding was studied in a collection of de novo heme proteins derived from combinatorial libraries of sequences designed to fold into 4-helix bundles. The design of the de novo sequences was based on the previously reported “binary code” strategy, in which the patterning of polar and nonpolar amino acids is specified explicitly, but the exact identities of the side chains are varied extensively.1 The combinatorial mixture of amino acids included histidine and methionine, which ligate heme iron in natural proteins. However, no attempt was made to explicitly design a heme binding site. Nonetheless, as reported previously, approximately half of the binary code proteins bind heme.2 This collection of novel heme proteins provides a unique opportunity for an unbiased assessment of the functional potentialities of heme proteins that have not been prejudiced either by explicit design or by evolutionary selection. To assess the capabilities of the de novo heme proteins to bind diatomic ligands, we m...
Atrioventricular canal defect: Two-patch repair and tricuspidization of the mitral valve

Between November 1978 and May 1991, a two-patch repair with tricuspidization of the left atrioventricular valve was performed in 104 patients with complete atrioventricular canal defect. Mean age was 12 months for the 68 patients who underwent primary repair and 22 months for the 36 patients who had previous pulmonary artery banding. Eleven patients died within 30 days of operation and 4 died late. Reoperation was carried out in 2 patients. Eighty-six patients were in sinus rhythm after operation. One patient required a permanent pacemaker for complete heart block. Follow-up data for 1 to 13 years are available in 80 of 89 survivors (90%). Actuarial survival at 13 years is 81% and event-free survival is 92%. Seventy-six patients are in New York Heart Association class I and 4 in class II. Postoperative echocardiogram of these patients showed minimal or no mitral regurgitation. The advantages of this technique are preservation of valve integrity, durable mitral valve repair, and rare reoperation or heart block even in younger patients.
Batterer program directors’ views on substance abuse and domestic violence

This article reports on a national survey of batterer intervention program (BIP) directors (N = 150). The beliefs of these directors on the relationship of substance abuse and domestic violence is reported and discussed. BIP director's opinions are important because they make programmatic and treatment decisions. Most BIP directors believe that for many of their clients, both men and women, perpetrator and victim, violence and substance abuse is related. Treatment and methodological considerations are discussed.
Pictures, words, and the structure of the trace in immediate recall

The reduction-cuing method was used to investigate the trace structure associated with both pictorial and verbal stimuli. The results indicate that those aspects of the trace assumed to be encoded as both pictorial and verbal mediators were in fact accessible to pictorial cues, but not to word cues. Furthermore, no evidence was obtained for any aspect of the trace composed of verbal but not pictorial elements. These outcomes are not consistent with a strict dual coding hypothesis, but they can be interpreted within the context of a transformational hypothesis.
Hormonal effects on mitotic rhythm in the epidermis of the red-spotted newt ☆

Abstract The mitotic indices of epidermal cells in the red-spotted newt were measured at 3- or 4-hr intervals throughout 24-hr periods under a variety of hormonal conditions. In intact control newts maintained on a photoperiod of 16 hr of light/8 hr of darkness, a peak in mitotic activity was observed during the dark hours and a second smaller (but not statistically significant) peak was seen during the light hours. Inversion of the light cycle induced a new and more rapid rhythm. The basic rhythm was accentuated by autografting the pituitary gland to an ectopic site and also by the administration of thyroxine to intact animals. Hypophysectomy and administration of the prolactin-inhibiting drug, ergocornine, to auto-grafted animals greatly reduced the rate of epidermal proliferation and apparently reduced the peaks until they were no longer detectable. Injection of ovine prolactin into hypophysectomized or intact animals elevated the overall mitotic index and obscured or altered the mitotic rhythm. Removal of the rhyroid gland or administration of thiourea also altered the rhythm, but treatment with ACTH produced no detected effect. Apparently the basic rhythm of epidermal mitosis can be overridden or altered either by hormonal factors that increase or by ones that decrease the overall rate of cellular proliferation.
Using Practitioners' Viewpoints To Improve Accounting Students' Communications Skills

The accounting profession has recognized the importance of emphasizing written and oral communications skills in the accounting curriculum. Innovations in tech nology have greatly enhanced educators' abilities to incorporate instruction in such skills. A survey of practitioners indicates strong agreement with the new writing requirements of the CPA exam. In addition, they endorse the use of information technology in preparing documents based on specific models and prescribed criteria.
Higher Levels of c-Met Expression and Phosphorylation Identify Cell Lines With Increased Sensitivity to AMG-458, a Novel Selective c-Met Inhibitor With Radiosensitizing Effects

Purpose c-Met is overexpressed in some non-small cell lung cancer (NSCLC) cell lines and tissues. Cell lines with higher levels of c-Met expression and phosphorylation depend on this receptor for survival. We studied the effects of AMG-458 on 2 NSCLC cell lines. Methods and Materials 3-(4,5-Dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assays assessed the sensitivities of the cells to AMG-458. Clonogenic survival assays illustrated the radiosensitizing effects of AMG-458. Western blot for cleaved caspase 3 measured apoptosis. Immunoblotting for c-Met, phospho-Met (p-Met), Akt/p-Akt, and Erk/p-Erk was performed to observe downstream signaling. Results AMG-458 enhanced radiosensitivity in H441 but not in A549. H441 showed constitutive phosphorylation of c-Met. A549 expressed low levels of c-Met, which were phosphorylated only in the presence of exogenous hepatocyte growth factor. The combination of radiation therapy and AMG-458 treatment was found to synergistically increase apoptosis in the H441 cell line but not in A549. Radiation therapy, AMG-458, and combination treatment were found to reduce p-Akt and p-Erk levels in H441 but not in A549. H441 became less sensitive to AMG-458 after small interfering RNA knockdown of c-Met; there was no change in A549. After overexpression of c-Met, A549 became more sensitive, while H441 became less sensitive to AMG-458. Conclusions AMG-458 was more effective in cells that expressed higher levels of c-Met/p-Met, suggesting that higher levels of c-Met and p-Met in NSCLC tissue may classify a subset of tumors that are more sensitive to molecular therapies against this receptor.
Melanocyte-Stimulating Hormone Activity in Pituitaries of Frogs with Hypothalamic Lesions

Melanocyte-stimulating hormone (MSH) activity in pituitaries of frogs with hypothalamic lesions was compared by bio-assay with the activity of this hormone in pituitaries of intact frogs. There was a significant loss of MSH activity following hypothalamic destruction. The specificity of the assays was substantiated by simultaneous assays of ACTH activity, which was found to be similar in both groups. MSH activity demonstrated by parabiosis was greater in body fluids of lesioned frogs than in the controls. It appeared, therefore, that there was increased pituitary secretion and decreased pituitary storage of MSH activity in frogs with hypothalamic lesions. (Endocrinology 77: 45, 1965.)
Spark Plasma Sintering of ZrB2–SiC–ZrC ultra-high temperature ceramics at 1800 °C

Abstract The compositional effects in ZrB2–SiC–ZrC ultra high temperature composites with four different compositions were investigated via Spark Plasma Sintering (SPS) at a maximum temperature of 1800 °C. Density, Rockwell hardness, and thermal conductivity were measured, along with structural X-ray diffraction (XRD) and microstructural characterization. The relative amounts of SiC and ZrC had an influence on the composites’ density, mechanical and thermal properties.
Growth, carbon sequestration, and management of native tree plantations in humid regions of Costa Rica

The Costa Rican government has provided incentives for reforestation programs since 1986 and initiated a Payment for Environmental Services program in 1996. These incentives yielded native species reforestation programs throughout the country. This research aims to provide information about growth, carbon sequestration, and management of seven native tree species (Vochysia guatemalensis, Vochysia ferruginea, Hyeronima alchorneoides, Calophyllum brasiliense, Terminalia amazonia, Virola koschnyi, and Dipteryx panamensis) growing in small and medium-sized plantations in the Caribbean and Northern lowlands of Costa Rica. A total of 179 plots were evaluated in 32 farms. Overall, I found that V. guatemalensis, V. ferruginea, H. alchorneoides, and T. amazonia were the species with the fastest diameter, total height, and volume growth; and T. amazonia and D. panamensis sequestered more carbon. Moreover, I found that the plantations that had been thinned before this assessment had the best growth. The results of the present research enhance the criteria elaborated in previous research findings to improve species choices for reforestation and silvicultural management in Costa Rica and in other regions with similar ecological features. Furthermore, they support the concept that tropical plantations can serve diverse economic, social, and ecological functions that may ultimately help reduce atmospheric CO2 accumulation.
Near‐surface imaging using coincident seismic and GPR data

In many near-surface applications, detailed subsurface characterization is important. Characterization often is obtained using ground-penetrating radar (GPR) or shallow seismic-reflection (SSR) imaging methods, depending upon depth of interest and surficial geology. Each method responds to different physical properties; thus, each may produce different images of the same near-surface volume. By incorporating the two methods, we generated a cross-section of the subsurface at an alluvial test site and identified the depths of three interfaces accurately to ±5 cm. We present here experimental results and examples of SSR and GPR images obtained along the same traverse, showing coincident and noncoincident reflections from multiple interfaces within 3 m of the surface.
A Method for Preparing Pelleted Clay Samples of Semi-Micro Quantity for Differential Thermal Analysis

A semi-micro quantity (10-15 mg) sample of clay is pressed into a 3 mm diameter pellet for differential thermal analysis (DTA) in a STONE-TRACOR ring microsample holder. The pellet is transferred to the sample holder dish with a vacuum tweezers. Platinum sample dishes are also handled by vacuum tweezers to avoid denting the dishes or damaging the thermocouple wires. The DTA curves obtained by the pellet method are highly reproducible. The resolution and sensitivity of reaction peaks are equivalent to or better than those produced by a large sample (200 mg) packed into a nickel block holder.
Assessment of the Reliability of Motors in Utility Applications - Updated

An Industry Assessment Study (IAS) was conducted to evaluate the present reliability of powerhouse motors and to identify design and operational characteristics which, through advanced development, offer the potential of increased motor, and therefore, power plant reliability. The primary objective of the IAS was to collect, analyze, and interpret candid, detailed information concerning motor application, operating factors, installation, manufacturer, failures and causes of failures. The survey data covers 6312 motors from 168 generating units representing 65 utilities. This data covers 40 percent of the population surveyed. The large quantity of data allows a meaningful analysis when it is broken down into smaller groupings.
Temperature-dependent predator-prey mite ecosystem on apple tree foliage

The biological control of the McDaniel spider mite, which is a pest on apple tree foliage, by a predacious mite species, which feeds upon it, is represented by a continuous-discrete time hybrid model incorporating temperature effects explicityland mite metamorphosis implicitly. The results of this model can be shown to provide good agreement when compared with relevant field data.
Enhancing Equity in Gifted Education: a framework for examining assessments drawing on the theory of multiple intelligences

In the United States, poor and minority students are disproportionately excluded from programs for the gifted. Current identification practices for gifted education programs are a primary barrier for these youngsters. This study investigated three alternative assessments for identifying students. Each was said to draw on the theory of multiple intelligences (Gardner, 1983) and to increase the identification of traditionally under‐served youngsters. This investigation asked: (1) Is it reasonable to associate increases in the identification of under‐served youngsters with these assessments? (2) Is it reasonable to associate each assessment with the theory of multiple intelligences? To answer these questions, qualitative data were analyzed against a framework of eight criteria. This revealed that no assessment met all eight criteria; each met a different subset of the eight.
Environmental Control of the Calicheamicin Polyketide Synthase Leads to Detection of a Programmed Octaketide and a Proposal for Enediyne Biosynthesis

The enediyne natural products exhibit potent antitumor and antibiotic activity in addition to displaying structural features that are quite remarkable both as a synthetic challenge and a biosynthetic enigma.[1] Members of this group typically incorporate a structural component designed for DNA recognition and a carbocyclic core containing an alkene (or masked alkene) flanked by triple bonds. It is this enediyne moiety that gives this class of compounds their name and their potent activity.
Optimization of hypersonic aircraft using genetic algorithms

Abstract A methodology has been developed to take advantage of hypersonic aircraft design characteristics to allow design optimizations using computational fluid dynamics and genetic algorithms. This methodology highlights the inherent advantages obtained from decoupling and then adding via explicit formulations, the viscous, thermal, species-transport and combustion physics into the implicitly solved Euler formulations of fluid flow. The resulting formulation is found to be robust and less sensitive to volume mesh refinement, thereby making it possible to use an automated mesh generation process. The mesh generator also takes advantage of the inherent two-dimensionality of the fluid flow around hypersonic aircraft and uses block-structured rhombohedrum meshes that are easy to control using an optimizer. A sample case study is presented in the form of the X-43 hypersonic aircraft which is then optimized for a Mach 6.5 flight using this new methodology.
Complete sequencing and characterization of equine aggrecan

Objectives: To fully sequence and characterize equine aggrecan and confirm conservation of major aggrecanase, calpain and matrix metalloproteinase (MMP) cleavage sites. Methods: Reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends were used to generate clones that encompassed the complete equine aggrecan sequence. Clones were sequenced and compared with the equine genome database to determine intron-exon boundaries. Results: The aggrecan gene spans over 61 kb on chromosome 1 and is encoded by 17 exons. Two major variants of aggrecan were cloned; one containing 8187 bp (2728 amino acids) and a second sequence of 8061 nucleotides (2686 amino acids). The variation was due to a CS1 domain polymorphism. Both sequences are substantially larger than predicted by the genomic database; 11 CS1 repeat elements are absent in the database sequence. The equine amino acid sequence was compared with human, bovine and murine sequences. Globular domains 1, 2 and 3 are highly conserved (overall identity over 80%). Equine CS1 is considerably larger than in other species and, therefore, is the least conserved domain (an overall amino acid identity of 22%). Previously defined aggrecanase, calpain and MMP cleavage sites were identified. Western blotting of chondrocyte culture samples showed complex post-secretion processing. Clinical significance: The complete equine aggrecan sequence will support more in-depth research on aggrecan processing and degradation in equine articular cartilage and other musculoskeletal tissues.
Early reading: A developmental psycholinguistic approach

Experimental studies of reading in children as young as two or three years of age have indicated several factors: children from various socioeconomic backgrounds with a wide IQ range can learn to read words relatively easily during their first years; early readers tend to read better later on than matched non‐early readers; early reading has not been shown to lead to eye injury or to emotional disturbance; young children generally enjoy reading; early readers have not been shown to be confused by differing preschool‐school teaching methods nor need they be bored in first grade. Current controversy about teaching reading is discussed as an outgrowth of historical theoretical viewpoints. Data on early reading, information about early bilingualism, and findings among children without early exposure to spoken language contribute to the viewpoint presented here that learning to read, if prevented until age six, may be similar to learning a second language. Some parallels between the course of early reading and...
Solitary (hemorrhagic) cyst of the mandible.

Abstract 1. 1. A case of an extensive hemorrhagic cyst of the mandible is presented. 2. 2. The clinical and radiographic findings were interpreted by the surgeon as an ameloblastoma and radical operation was performed without previous biopsy. 3. 3. Histologic study of the resected mandible supports the theory that this lesion results as a sequela of an intraosseous hematoma. Undermining resorption of the cortex appeared to be a major factor in enlargement of the cyst.
A naturalistic comparison of adverse effects between slow titration and loading of divalproex sodium in psychiatric inpatients

Background: This study compares the incidence, severity and onset of treatment-emergent adverse effects between slow titration and loading of divalproex sodium in psychiatric inpatients. Method: Forty-seven patients were prescribed either loading or slow titration of divalproex sodium. Under single-blind conditions, adverse effects were assessed using a valproate adverse effects rating scale. Except for a statistically significant greater incidence of somnolence in the slow titration group, no statistically or clinically significant differences in incidence, severity or onset of treatment-emergent adverse effects were found between groups. Results/Conclusion: Overall, adverse effects were well tolerated by both groups.
Evaluation and Multimodality Treatment of a Depressed Prepubertal Girl

Abstract This paper provides the framework for assessing and treating chronically depressed, multiproblem children. A clinical case study was chosen as the vehicle to illustrate, in a sequential manner, an approach which utilizes intensive milieu interventions, dynamically oriented psychotherapy, antidepressant medication, and behavior therapy (social skills training) to convey the rationale and methodology for a pragmatic, comprehensive, multi-modal approach to the therapy of chronically depressed children.
Hyperfine Structure and Isotope Shift of 30-Year 207 Bi in the 3067-Å Resonance Line*

A 10-m focal length Czerny–Turner monochromator was used to photograph the emission spectrum of 30-year 207Bi in the 3067-A transition to obtain the hyperfine spectrum and the isotope shift with respect to the naturally occurring isotope 209Bi. A procedure was developed for making a low-impurity electrodeless spectral lamp utilizing only nanogram quantities of 207Bi. The radioisotope was produced in a cyclotron bombardment of natural lead, followed by mass separation. Because the nuclear spin, I, of 207Bi is at present unmeasured, the calculated values for the 207Bi magnetic-dipole and electric-quadrupole constants A and B, respectively, and the isotope shift are based on I=92, which is expected on the basis of the nuclear-shell model. The results are ​207Bi A(6p27s⁴P12)=163.8±0.5mKA(6p3⁴S32°)=−14.87±0.06mKB(6p3⁴S32°)=−13.3±5.0mK​207Bi−​209Bi isotope shift=27.3±5.0mK,with the center of gravity of 207Bi on the lower-wavenumber side.
Functional Polymers XLV. Incorporation of Dihydroxy 2(2-Hydroxyphenyl) H-Benzotriazole Derivatives into Polyesters

2(2,4-Dihydroxyphenyl) H-4-hydroxybenzotriazole and 2(2,4-dihydroxy-phenyl)2H-1,3-di(4-hydroxybenzotriazole) were incorporated in amounts of 1 to 10 mol% into examples of typical aliphatic or aromatic polyesters, either by direct synthesis from the monomers or by transesterification from already prepared polyesters. The polyesters showed UV spectra typical for the 2(2-hydroxyphenyl)2H-benzotriazole unit in amounts approximately corresponding to the feed composition. Some complications in the direct incorporation of dihydroxy-2(2-hydroxyphenyl)2H-benzotriazoles into polyesters were encountered when the diacid chloride method was used for the preparation of the polyesters; branched and crosslinked polyesters were obtained.