cssi/SciSciGPT-SciSciNet huggingface dataset:
Thinking About Our Work: Effects of Publishing on Therapists

161 1 Professor Emeritus, University of Cincinnati. Correspondence should be addressed to Walter N. Stone, MD, 23 DeSilva Island Drive, Mill Valley, CA 94941. E-mail: w_stone@comcast.net. In her discussion of Freud’s 1910 article “Wild Analysis,” Muriel Dimen (2014) offhandedly states that we don’t often think about the impact on the therapist when the patient, usually a clinician, is aware that the therapist also is an author and may write about the therapeutic encounter. Dimen comments, “With another patient not in the field and/or about whom I would not be writing, my tack would inevitably be different” (p. 510). Dimen is highlighting the bi-personal nature of the relationship. I found myself intrigued by her disclosure, not only about patients who are clinicians, but about all patients. I wondered how this referenced me and may have impacted my writing about clinical material. In “Thinking About Our Work: Case Presentations” (Stone, 2014), I explained how I informed the group members about my writing and publications. I understood that patients fear exposure, and I was disguising their identities. With some groups, I read portions of what I had written. However, I had not attended to or even been aware of how I may have subtly and unknowingly altered my own subsequent responses following their commenting on my writing. I believed that I had ethically fulfilled my responsibility by informing the members about my writing, but I did not think more deeply into how their knowing about my writing had impacted me and how I subsequently interacted and spoke with them. What Dimen brings to the table is the situation that occurs when both patient and therapist know of the publication and the therapist is inhibited from saying things that might be said in the absence of writing, publishing, or presenting the therapeutic work. I certainly, even retrospectively, cannot recall changing how I
The early results of treatment of simple transposition in the current era

A total of 187 neonates with simple transposition of the great arteries (TGA) have been entered into a twenty institution cooperative study between Jan. 1, 1985, and June 1, 1986. Eighty-two percent entered within the first 2 days of life. Seventy-six of the 187 patients were initially entered into a treatment protocol leading to an arterial switch repair, 45 into one leading to an atrial switch (Mustard) repair, and 49 into one leading to a Senning repair. Five (7%) of the patients entered initially into an arterial switch protocol later were crossed over to an atrial switch protocol, and 7% of those entered into an atrial switch (Mustard) protocol were crossed over to an arterial switch protocol. Formal follow-up information is available on all patients. Only 5% of patients entered into an arterial switch protocol were without repair 2 weeks after entry, whereas 96% and 100%, respectively, of those entered into a Mustard or Senning atrial switch protocol were without repair at that time. Ninety-seven percent of the first group had no preliminary procedures other than balloon atrial septostomy, which was true of only 76% and 90%, respectively, of the last two groups. No deaths before repair occurred in the first group, whereas five occurred in the latter two groups (P = 0.06). Overall survival rate among the 187 patients was 81% at 1 year. The only risk factors for death were birth weight, date of entry into the study, and an arterial switch protocol in the group of institutions at high risk for arterial switch repair; neither an arterial nor an atrial switch protocol was a risk factor per se. According to the multivariate equation, the 12-month predicted survival rate of a patient with a birth weight of 3.4 kg, entered currently into atrial or arterial switch protocols (except in the high risk for arterial switch group of institutions) is 92%.
SORL1 variants across Alzheimer’s disease European American cohorts

The accumulation of the toxic Aβ peptide in Alzheimer’s disease (AD) largely relies upon an efficient recycling of amyloid precursor protein (APP). Recent genetic association studies have described rare variants in SORL1 with putative pathogenic consequences in the recycling of APP. In this work, we examine the presence of rare coding variants in SORL1 in three different European American cohorts: early-onset, late-onset AD (LOAD) and familial LOAD.
Ultrathin hafnium oxide with low leakage and excellent reliability for alternative gate dielectric application

Physical, electrical and reliability characteristics of ultra thin HfO/sub 2/ as an alternative gate dielectric were studied for the first time. Crucial process parameters of oxygen modulated dc magnetron sputtering were optimized to achieve an equivalent oxide thickness (EOT) of 11.5 /spl Aring/ without deducting the quantum mechanical effect. Leakage current was 3/spl times/10/sup -2/ A/cm/sup 2/ at +1 V. Excellent dielectric properties such as high dielectric constant, low leakage current, good thermal stability, negligible dispersion and good reliability were demonstrated.
Cyber Victimization and Depression Among Adolescents With Intellectual Disabilities and Developmental Disorders: The Moderation of Perceived Social Support

The aim of this study was to examine the mitigating effect of perceived social support from parents, teachers, and friends on the association between cyber victimization and depression, accessed on...
Retrospective review of serotonergic medication tolerability in patients with neuroendocrine tumors with biochemically proven carcinoid syndrome.

BACKGROUND Patients with carcinoid tumors frequently could benefit from the pharmacologic treatment of depression and anxiety. However, many prescribers avoid serotonergic medications due to the theoretical risk of exacerbating carcinoid syndrome. METHODS The authors conducted a retrospective chart review of patients with carcinoid tumors and elevated serotonin levels (as measured by 24-hour urine 5-hydroxyindoleacetic acid [5-HIAA]) at Dana-Farber/Brigham and Women's Cancer Center who initiated treatment with serotonergic antidepressants after a carcinoid diagnosis from 2003 to 2016. Each medication regimen was categorized based on the presence of adverse interactions as defined by clinical worsening of symptoms of carcinoid syndrome in the absence of progressive disease that temporally correlated with a serotonergic medication trial. RESULTS A total of 73 serotonergic regimens received by 52 patients were included in the primary analysis. Among these medication trials, 8.2% of the regimens (6 regimens) were categorized as being associated with a likely adverse interaction, 61.6% of the regimens (45 regimens) were categorized as having no adverse reaction, 9.6% of the regimens (7 regimens) were categorized as an unlikely adverse reaction, and 20.6% of the regimens (15 regimens) were categorized as unknown. It is interesting to note that none of the 73 trials resulted in a carcinoid crisis requiring emergency care or hospitalization. Only 3 patients discontinued serotonergic medications due to worsening carcinoid syndrome. CONCLUSIONS Serotonergic medications appear to be a safe option for the treatment of depressive and anxiety symptoms in the majority of patients with neuroendocrine tumors and carcinoid syndrome. In the current study, <10% of patients developed a combination of flushing, diarrhea, and bloating after the initiation of serotonergic medications. Clinicians can begin with low doses, monitor these symptoms, and reduce the dose or discontinue the medication if necessary. Cancer 2017;123:2735-42. © 2017 American Cancer Society.
Soybean Micronutrient Content in Irrigated Plants Grown in the Midsouth

ABSTRACTConcentrations and contents of iron (Fe), boron (B), zinc (Zn), manganese (Mn), and copper (Cu) were determined for two MG IV and one MG V irrigated soybean (Glycine max L. Merr.) cultivars grown on clay and sandy loam soils in 2011 and 2012. Plants were sampled at V3, R2, R4, R6, and R8, tissues separated, dried, weighed, and nutrient concentrations determined. Nutrient contents were calculated. No cultivar, site, or year differences in nutrient concentrations or contents were observed. Iron had the greatest concentration and content of all followed by B, Zn, Mn, and Cu. Maximum concentrations and contents in leaves occurred at R4 and later declined. Concentrations and contents in stems remained constant or increased while pods rapidly increased until (R8). A 3328 kg ha−1 seed yield will remove 325.0 g Fe ha−1, 153.9 g B ha−1, 175.6 g Zn ha−1, 100.0 g Mn ha−1, and 52.5 g Cu ha−1.
Water permeation and corrosion resistance of single- and two-component hydrophobic polysiloxane barrier coatings

The degradation of corrosion preventative coatings contributes to the high cost and time requirements for maintaining structures in harsh environments. However, the development of new hydrophobic coatings holds the promise of extending the usable life of structures in marine environments. In this work, we quantify the barrier properties and corrosion resistance of two novel highly hydrophobic polysiloxane formulations and the legacy silicone alkyd topcoat used on the topside of Navy’s ships, all with haze gray pigmentation. Based on FTIR-ATR and EIS measurements of the pristine coatings, both the single- (1K) and the two-component (2K) polysiloxane provide significantly improved barrier characteristics (lower water diffusion coefficient and capacitance) than the silicone alkyd. These results were confirmed through a 3-month-long immersion corrosion test, which also showed that the 1K and 2K polysiloxane coatings had comparable degradation characteristic and remained highly hydrophobic.
Prevalence and correlates of hepatitis C virus-associated inflammatory arthritis in a population-based cohort.

Abstract Objectives The objectives of this study were to determine the prevalence of hepatitis C virus–associated inflammatory arthritis, to describe its clinical and immunologic correlates, and to identify features that are characteristic of arthritis in chronic hepatitis C. Methods Participants with chronic hepatitis C infection enrolled in a population-based cohort study in Alaska and who had not received anti-viral treatment for hepatitis C were recruited. In a cross-sectional study, we assessed joint symptoms and signs, performed autoantibody and cytokine testing, and abstracted medical records for features of hepatitis C and arthritis. Results Of the 117 enrolled participants, 8 (6.8%) had hepatitis C-associated arthritis. The participants with arthritis were younger than those without (median age: 45 vs. 52, p = 0.02). Rheumatoid factor was commonly present among patients with hepatitis C-associated arthritis. The only studied autoantibody found more commonly in patients with HCV arthritis than those without arthritis was anti-nuclear antibody (63% vs. 23%, p = 0.026). The only joint symptom significantly more common in hepatitis C arthritis was self-reported joint swelling (75% vs. 26%, p = 0.007). Features of fibromyalgia were more common and functional status was worse in those with arthritis than those without. No cytokines differed in patients with and without arthritis. There were no associations of arthritis or autoantibodies with liver-related outcomes. Conclusions In this study of a cohort of individuals with chronic HCV infection, HCV-associated arthritis was present in less than 10%. Few serologic features distinguished participants with or without arthritis, but self-reported joint swelling was more common in those with arthritis.
Revelation effects in remembering, forecasting, and perspective taking

The revelation effect is a robust phenomenon in episodic memory whereby stimuli that immediately follow a simple cognitive task are more likely to garner positive responses on a variety of memory tests, including autobiographical memory judgments. Six experiments investigated the revelation effect for judgments of past and future events as well as judgments made from others’ perspectives. The purpose of this work was to determine whether these subjectively distinct judgments are subject to the same decision-making biases, as might be expected if they are governed by similar processes (e.g., Schacter, Addis, & Buckner 2007). College-aged participants were asked to rate a variety of life events according to whether the events had occurred during their childhoods or would occur during the next 10 years. Events that followed an anagram task were judged as more likely to have happened in the past and more likely to occur in the future. We also showed a revelation effect when participants were asked to adopt the perspective of others when making judgments about past and future events. When the task was reworded to be non-episodic (participants judged how common the events were during childhood and adulthood), no revelation effect was found for either past or future time frames, which suggests common boundary conditions for both types of judgments. The results are consistent with studies showing strong parallels between remembering and other forms of self-projection but not with semantic memory judgments.
Historiometry in Organizational Science: Renewed Attention for an Established Research Method

Historiometric analysis (HMA), an organized set of content analytic techniques, allows researchers to convert historical information into numeric data that are appropriate for complex statistical a...
AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland ( Squalus acanthias).

The production of endogenous adenosine during secretagogue stimulation of CFTR leads to feedback inhibition limiting further chloride secretion in the rectal gland of the dogfish shark (Squalus aca...
Draft Genome Sequence of Lactobacillus paracasei DUP 13076, Which Exhibits Potent Antipathogenic Effects against Salmonella enterica Serovars Enteritidis, Typhimurium, and Heidelberg

ABSTRACT Lactobacillus paracasei DUP 13076 demonstrates antagonistic effects against the foodborne pathogens Salmonella enterica serovars Enteritidis, Typhimurium, and Heidelberg in coculture and in vitro experiments. Here, we report the draft genome sequence of Lactobacillus paracasei DUP 13076, which has a circular chromosome of 3,048,314 bp and a G+C content of 46.3%.
Responding to bereaved people’s words about relationship system loss

People grieving a death may grieve not only the loss of the person who died but also relationship systems lost because of the death. Relationship systems can be defined as what goes on between or a...
Psychological Aspects of Acute Trauma: Intervening with Children and Families in the Inpatient Setting

Working with children who are injured by sudden, traumatic events requires a multifaceted approach. The psychological consultant is in a key position to provide assessment, intervention, family and staff education, and ongoing support that will assist in the child’s and family’s working-through and successful mastery of the trauma. This article discusses specific considerations, approaches, and interventions that are important to the care of children and their families after acute traumatic injury.
Men of Honor: Examining Individual Differences in Masculine Honor Beliefs

The experience of masculinity includes many expectations for what it means to be a man. Research has demonstrated that men raised in the American South incorporate into their identities the beliefs that provocation requires an aggressive response so that they may solidify their masculinity and reduce their future vulnerability to transgressions. We contend that while there are cultural differences in the extent to which men embrace honor as key to their masculinity, there is variability among men within the same culture, beyond the American South, and this variability provides meaningful prediction of men’s perceptions of and reactions within various social situations. Thus, examining masculine honor beliefs from an individual difference perspective provides greater understanding of male identity in cultures outside of the American South. The purpose of this chapter is to describe our research on the measurement and predictive utility of individual differences in men’s adherence to masculine honor beliefs.
RNA Polymerases and Transcription Factors of Trypanosomes

RNA synthesis in trypanosomatid organisms deviates substantially from what we see in model organisms. In these parasites, protein-coding genes are arranged in long tandem arrays that are polycistronically transcribed by an unresolved mode of transcription initiation. Moreover, the African Trypanosoma brucei has evolved a multifunctional RNA polymerase I system which it employs for pre-rRNA synthesis as well as for transcription of specific gene units encoding its major cell surface antigens. Additionally, the trypanosomatid RNA polymerase III system, by relying mostly on bidirectional tRNA gene promoters, exhibits clear differences to other eukaryotic systems. Interestingly, annotation of completed trypanosomatid genomes revealed only a small subset of basal transcription factors (BTFs), which suggested that trypanosomes have a simplified transcription machinery. Recent research, however, has demonstrated that trypanosomes possess extremely divergent orthologs of most BTFs and that these factors deviate in many aspects from their human counterparts; they are the focus of this chapter.
Genetic risk score for Alzheimer’s disease is associated with poor hearing

Abstract Introduction Incipient dementia or shared genetics may partly explain the association between hearing loss and dementia. We evaluated whether genetic variants known to increase Alzheimer’s disease (AD) also influence hearing difficulty. Methods UK Biobank participants aged 56+ with Caucasian genetic ancestry self-reported difficulty hearing and hearing with background noise (n=244,915) and underwent objectively measured hearing assessments (n=80,074). Poor objective hearing was defined as >-5.5 dB speech reception threshold on a Digit Triplet Test. We evaluated whether an AD genetic risk score (AD-GRS; range −1.2 to 1.9), the weighted sum of 23 previously identified AD-related polymorphisms, predicted objective or self-reported poor hearing, using age, sex, and genetic ancestry adjusted logistic regression models. Results Higher AD-GRS predicted objectively measured poor hearing (OR=1.06; 95% CI: 1.01, 1.11) and self-reported problems hearing with background noise (OR=1.03; 95% CI: 1.00, 1.05). Discussion Using novel methods, we found evidence that AD genetic risk influences hearing loss.
Book Review of Pathways to Pacifism and Antiwar Activism among U.S. Veterans: The Role of Moral Identity in Personal Transformation by Julie Putnam Hart and Anjel N. Stough-Hunter

This essay reviews Pathways to Pacifism and Antiwar Activism among U.S. Veterans, coauthored by sociologists Julie Putnam Hart and Anjel N. Stough-Hunter. Pathways to Pacifism chronicles the journey of 114 Vietnam, Korea, and Iraq veterans from war supporters to antiwar activists. Hart’s and Stough-Hunter’s research seeks to understand the catalysts that shift veterans from a pro-war to an emphatically antiwar activist stance.
Survival of Escherichia coli O157:H7 and Listeria monocytogenes in an acidified low-fat mayonnaise based hibachi sauce

Abstract Survival of pathogenic bacteria under acidic conditions may pose a significant food safety challenge and should be assessed when developing new food products. The objective of this study was to determine the antimicrobial effect of two acidulants against Escherichia coli O157:H7 and Listeria monocytogenes in a low-fat mayonnaise based hibachi sauce subjected to different preparation and storage conditions. A mixture of seasoning and acidulants was heated to 82.2 °C and cooled. This was combined with a low-fat mayonnaise and acidified with either 0.25 g lactic acid/100 g sauce, 0.25 g, or 0.5 g vinegar/100 g sauce. The sauce was then inoculated with L. monocytogenes and E. coli O157:H7 at the levels of ca. 6 log CFU/g each, and stored at 4 or 23 °C. Both pathogens survived longer at 4 than at 23 °C (P 0.5 g vinegar/100 g sauce > unacidified control. At 23 °C, populations of both bacteria decreased by at least 4 log CFU/g after 72 h of storage in formulations containing 0.25 g lactic acid/100 g sauce. Acidification with lactic acid can improve food safety of mayonnaise based sauces in case of post processing contamination.
Advanced Filtration Membranes for the Removal of Perfluoroalkyl Species from Water

Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are two perfluoroalkyl substances that have been shown to result in several adverse health effects, including birth defects, k...
Survivorship and Clinical Outcomes of Custom Triflange Acetabular Components in Revision Total Hip Arthroplasty: A Systematic Review

Abstract Background Several studies have evaluated the survivorship and clinical outcomes of custom triflange acetabular component (CTAC) usage in complex acetabular revision; however, there remains no consensus on the overall performance of this custom implant design. We therefore performed a systematic review of the literature in order to examine survivorship and complication rate of CTAC usage. Methods A systematic review of the literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was performed. A comprehensive search of PubMed, MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews was conducted for English articles using various combinations of the keywords “custom triflange,” “custom-made triflange,” “acetabular triflange,” “THA,” “THR,” “revision,” “bone loss,” “bone defect,” and “pelvic discontinuity.” Results In all, 17 articles met our inclusion criteria. A total of 579 CTACs were implanted. The all-cause revision-free survivorship was 82.7%. The overall complication rate was 29%. Dislocation and infection were the most common complications observed with an incidence of 11% and 6.2%, respectively. Nerve injuries following CTAC placement had an incidence of 3.8%. The incidence of CTAC aseptic loosening was 1.7%. Overall, patients had improved outcomes as documented by postoperative hip scores. Conclusion Based on the current data, CTACs have a high complication rate but remain an efficacious treatment option in complex acetabular reconstructions. When dealing with patients with significant acetabular bone loss for revision total hip arthroplasty, surgeons should continue to consider CTACs as a viable option but educate patients as to the increased risk of postoperative complications and reoperations.
Comparison of visual motor skills of typical women in their 30s with those of typical women in their 70s

Date Presented 04/06/19 Demographics related to aging of women in the US will be presented, and research related to changes in fine motor skills and other upper-extremity functioning as one ages will be summarized. A study comparing visual motor skills of typical women in their 30s with those of typical women in their 70s will be presented and clinical implications for practice addressed. Primary Author and Speaker: O. Jayne Bowman
Can we better predict delayed hemolytic transfusion reactions and hyperhemolysis in sickle cell disease

Delayed hemolytic transfusion reactions (DHTR) occurring in individuals with sickle cell disease (SCD) are usually indolent but may rarely progress to life-threatening hemolysis known as hyperhemolysis syndrome (HHS), which can be difficult to diagnose and manage. We evaluate a predictive model for DHTR proposed by Drs. Pirenne and Yazdanbakhsh. A scoring system and nomogram were utilized in three individuals with SCD and delayed hemolysis, with one likely having HHS. The scoring system is based on identified risk factors for developing hemolysis from patient transfusion history, while the nomogram utilizes persistence of hemoglobin A (HbA) which is not innate to SCD patients. We propose a novel method for HbA estimation to facilitate application of the nomogram. Application of the recently published predictive scoring system revealed a low risk of developing DHTR in one patient and an intermediate risk in two patients. As serial HbA values are not routinely assessed, HbA measurements were only available in one of the three patients, though use of the nomogram predicted a high likelihood of DHTR. The recently published predictive score and nomogram yielded mixed results and should be interpreted with caution when predicting the risk of developing DHTR in individuals with SCD. Management of DHTR/HHS continues to be a challenge for transfusion medicine and hematology services standardized methods to facilitate their early diagnosis and treatment are warranted to improve the safety of blood transfusions in individuals with SCD.
5PSQ-051 Immune related adverse events in cancer patients treated with control point inhibitors

Background and importance Despite the clinical benefits of therapy with control point inhibitors in several malignancies, this inhibition is closely linked to a series of immune related adverse events (irAEs). The early detection and management of these is of vital importance. Aim and objectives To identify and describe irAEs with programmed cell death protein 1 (PD-1) inhibitors and programmed death ligand 1 (PD-L1) inhibitors in clinical practice. Material and methods A retrospective, descriptive, observational study was conducted in a 400 bed hospital in patients treated with immunotherapy (IT) from 1 January 2016 to 30 October 2018. Variables were age, gender, type of tumour, stage, IT, irAEs and grade, cycles until irAE appearance, irAE treatment and IT suspension. The electronic medical history was reviewed in OrionClinic and IT treatment in Farmis-Oncofarm. The causality of irAEs was ascertained on the basis of the European Society for Medical Oncology (ESMO) algorithms. Statistical analysis was performed with SPSS V.15. Results A total of 127 patients were treated with an average age of 65 years (range 36–88) and 75% were women: 76% of patients had non-microcytic lung cancer, 7% head–neck, 6% bladder, 5% breast, 4% renal, 2% melanoma and colorectal cancer. In 67% of patients, stage IV tumours were found, in 27% stage III, in 4% stage II and in 2% stage I. Nivolumab was prescribed in 54% of patients, pembrolizumab in 26%, atezolizumab in 13% and durvalumab in 7%. Fifty-two irAEs were identified. The average number of cycles until irAE appearance was 3.25 (range 1–57). The main irAEs were cutaneous (37%), gastrointestinal (23%), pneumonitis (14%) and endocrinological (8%); 64% grade I, 25% grade II, 12% grade III and no grade IV. Treatment was given for 66% of irAEs: oral corticoids (52%), topical corticoids (17%), antihistamines (12%) and hormone replacement therapy (5%). IT was resumed in 83% of patients. By the end of the study period, 31% of patients remained on therapy. Non-continuity was due to progression (55%), irAEs (10%) and other reasons (4%). Conclusion and relevance The most frequent irAEs in patients receiving IT were cutaneous and gastrointestinal, mostly transitory and grades I–II. They were mostly resolved with corticotherapy and antihistamines. Management of irAEs was presented on the basis of clinical experience; cooperation of patients, caregivers and healthcare professionals is required to watch over their safety to obtain the maximum efficacy with the lowest irAEs possible. References and/or acknowledgements No conflict of interest.
Thirty-Day Outcomes After Bilateral Total Hip Arthroplasty in a Nationwide Cohort

Abstract Background Approximately 42% of patients with end-stage osteoarthritis have bilateral disease. Although bilateral total hip arthroplasty (THA) is physiologically demanding, certain patients may benefit from simultaneous rather than staged bilateral procedures. This study examines the intraoperative differences and 30-day outcomes in patients receiving bilateral THA compared with those who underwent unilateral THA. Methods Patients undergoing THA were selected from the National Surgical Quality Improvement Program database from 2008 to 2015. Patients were selected according to those with primary and concurrent coding for Current Procedural Terminology 27130. Thirty-day complications were recorded, and multivariate analyses were performed to determine whether concurrent THA was a risk factor for poor outcomes. Results A total of 97,804 patients and 587 patients who underwent unilateral and bilateral THA, respectively, were identified. Patients who underwent bilateral procedures were younger (57.3 vs 64.6 years, P Conclusions Although bilateral THA recipients are younger with fewer preoperative comorbidities, bilateral THA is associated with an increased rate of transfusion in a nationwide setting. With this knowledge, specific interventions should be instituted to target these procedure-specific risks.
Factors associated with frenotomy after a multidisciplinary assessment of infants with breastfeeding difficulties.

Abstract Objective Frenotomy for ankyloglossia has increased nearly 10-fold over the past few decades despite insufficient evidence that the procedure improves breastfeeding outcomes. There is no universally accepted method for identifying patients who may benefit from the procedure. The objective of this study is to determine if comprehensive feeding evaluations and targeted interventions can identify children who should undergo procedures, and to identify factors associated with lip or tongue frenotomy to treat breastfeeding difficulties. Methods This observational quality improvement study followed infant-mother dyads between March 2018 and December 2019 referred to our tertiary care center for breastfeeding difficulties. Speech and language pathologists performed comprehensive feeding evaluations on infants prior to surgical consultation for frenotomy. Infants’ oral anatomy and function and their ability to breast and bottle feed were assessed, and techniques for mothers to address feeding difficulties without a procedure were offered prior to surgical consultation. Infants either found success over a short observation period or underwent procedures (lip and/or tongue frenotomy). Results 153 patients (mean age 47.0 days (stdev 39.0 days, 56.2% male) were referred for surgical division of the lingual frenulum. Following development of a program utilizing pediatric speech language pathologists to perform feeding evaluations prior to surgical consultation, 69.9% of patients subsequently did not undergo surgical procedures. 11 (23.9%) underwent labial frenotomy alone and 30 (65.2%) underwent both labial and lingual frenotomies. Frenotomy was associated with significantly increased worry subscale of the Feeding Swallow Impact Survey (FSIS) and decreased mean Breastfeeding Self Efficacy Scale score (p = 0.0001, p = 0.006, respectively). Tongue appearance was significantly associated with having a procedure, while lip appearance was not. The Bristol Breastfeeding Assessment Tool (BBAT) was lower in children undergoing tongue and/or lip frenotomy (p = 0.0006), while the Hazelbaker Assessment Tool for Lingual Frenulum Function (HATLFF) appearance and function scores were lower in children undergoing lingual frenotomy with or without lip frenotomy (p = 0.0008, p = 0.0009, respectively). Conclusions The majority of patients referred for ankyloglossia may benefit from nonsurgical intervention strategies based on findings from comprehensive feeding evaluation. Frenotomy is associated with higher maternal feeding-related worry and reduced breastfeeding self-efficacy scores. While tongue appearance is associated with frenotomy, functional assessment is critical for identifying patients who may also benefit from lip frenotomy.
Optimizing corneal riboflavin administration in ex vivo horse, dog, rabbit, and pig samples for use in corneal collagen cross-linking.

Purpose Determine optimal iontophoresis times for riboflavin delivery to the corneal stroma across different species and compare these to corneal injection. Methods Ex vivo horse, dog, rabbit, and pig globes were treated with riboflavin administered with either iontophoresis for 2.5-20 minutes with or without corneal epithelium; or with purpose-designed precise corneal injection (PCI) application with intact epithelium. Immediately following riboflavin administration, samples were harvested, frozen, and sectioned. Riboflavin penetration was imaged using fluorescence microscopy. Results Horse samples processed with iontophoresis without epithelium for 2.5, 5, and 7.5 minutes, and processed with intact epithelium for 20 minutes, had mean percent stromal penetration (%SPmean ) of 63.4%, 93.8%, 100.0%, and 0.0% (respectively). Dog samples processed with iontophoresis without epithelium for 2.5 and 5 minutes, had %SPmean of 60.7% and 82.1% (respectively). Pig samples processed with iontophoresis for 5 minutes without and with epithelium had %SPmean of 63.3% and 35.1% (respectively). Rabbit samples processed with iontophoresis without epithelium for 2.5 and 5 minutes, had %SPmean of 81.8% and 100.0% (respectively). For all injected volumes, riboflavin was observed spanning throughout the corneal stroma, and lamellar separation was noted surrounding all sites of injection. Conclusions Both iontophoresis and injection via PCI needles provide efficient and effective means of riboflavin administration in ex vivo horse, dog, rabbit, and pig corneas. Epithelial debridement is required for stromal delivery of riboflavin using iontophoresis in horses. Following epithelial removal, riboflavin penetrated through the horse corneal stroma faster than all other species tested.
Using Deductive Reasoning to Identify Unhappy Communities

The complex interplay between media and population sentiment is a well-known, yet hard to model, phenomenon. The extrema of individual sentiment (euphoria and depression) are known to be correlated with people’s social interaction, including activity in forums and social-media sites. Yet causality direction of this correlation still requires scrutiny and scientific analysis. The difficulty of such analysis comes, first and foremost, from the complexity of sentiment quantification. It is even more difficult to measure a shared sentiment of a community, due to the echo chamber effect. In addition, media analysis presents its own computational challenges, which were insurmountable until recent times, when we have been presented with unprecedented technical possibilities for quantification of community sentiment and its factors at a level of granularity never seen before. Behavioral psychology suggests that people’s behavior can be used as a measurable proxy for their sentiment. Behaviorist theory has been enhanced with the proliferation of targeted advertising and marketing science in the corporate world, and a number of phenomena connecting people’s sentiment and social behavior have been explained using behavioral psychology. In addition, advances in the theory and practice of data mining and machine learning have enabled non-empirical approaches to quantitative sociological analysis and development of new indicators of communal well-being that rely on the analysis of historical data. These considerations make it possible to investigate the interactions between media sentiment and community. This is the theme of the present submission.
Contrasting population genetic structure in Acropora coral hosts and their algal symbionts across multiple spatial scales

Abstract Many broadly-dispersing corals acquire their algal symbionts (Symbiodiniaceae) from their environment upon recruitment. This horizontal transmission strategy has the potential to promote coral fitness across diverse environments provided that corals can associate with diverse algae across their range and that these symbionts exhibit reduced dispersal potential. Here we quantified genetic structure of algal symbionts in symbiosis with two hosts (Acropora hyacinthus, Acropora digitifera) across two spatial scales (across islands, within islands) in Micronesia using microsatellites. We contrast these symbiont genetic structures to previously published coral host structures across the same spatial gradient. We find that both hosts associated with two genetically distinct Cladocopium lineages (C3, C40), confirming that Acropora coral hosts associate with diverse algae across this range. In addition, each Cladocopium lineage exhibited signatures of moderate host specialization. Across locations, algal populations were significantly more genetically structured compared to their hosts: they demonstrated higher FST among islands and often exhibited significant divergence among reefs on the same island, which was never observed in coral hosts. While Cladocopium C3, like their hosts, broadly followed an isolation-by-distance pattern across islands, there was one notable case of no genetic structure across more than 2,000 km (between Yap and Pohnpei), demonstrating that Cladocopium genetic structure can be more complex than their hosts. Overall, our results support the view that horizontal transmission – establishing novel symbioses with local symbionts - has the potential to facilitate local fitness for broadly dispersing coral species, and highlight the complexity of factors affecting the population biology of Cladocopium.
Distributed Adaptive AC Droop Control in D-Q Coordinates for Inverter-Based Microgrids

Droop control is a conventional method for operation of local distributed sources. Typical issues for droop control schemes include current sharing mismatch and voltage deviation, both likely to occur in a Microgrid (MG) setting. This paper proposes an adaptive droop scheme in d-q coordinates to compensate for current sharing mismatch at primary control level and voltage deviation compensation at secondary control. The droop resistances are adjusted for both d and q subsystems to eliminate the current sharing mismatch, and the droop voltage shifting method has been implemented to compensate for the voltage deviation. The dynamics of the proposed control is demonstrated for a three-phase reduced-order MG system using OpenModelica.
Preservation of the Anterior Cruciate Ligament: Arthroscopic Primary Repair of Proximal Tears

Historically, inconsistent and disappointing outcomes of open primary repair of the anterior cruciate ligament (ACL) have been reported. Recently, however, there has been a resurgence of interest in primary repair resulting from better patient selection (only treating patients with proximal tears) and modern-day advances (arthroscopic surgery and modern-day rehabilitation). Preservation of the ACL has many advantages over the current gold standard of ACL reconstruction as the native tissue and biology are preserved, surgery is less invasive, and the incidence of osteoarthritis can potentially be decreased at longer follow-up.
When My-“asthenia” is NOT due to Myasthenia Gravis (2330)

Objective: To describe a short series of patients (n = 5) carrying a clinical diagnosis of myasthenia gravis, who then developed neurological symptoms, that were initially attributed to myasthenia gravis, but later led to the diagnosis of a secondary neurological condition. Background: Patients with myasthenia gravis often present with myriad of neurological symptoms (e.g.double vision, weakness, fatigue). On occasion, these symptoms may be falsely attributed to myasthenia gravis, when, in fact, the patient has developed an alternative neurological diagnosis. Design/Methods: A descriptive study of 5 patients (case-series). Results: We describe 5 patients with myasthenia gravis who have later developed concomitant neurological diseases: (1) A 69-year-old woman who developed diplopia and ptosis due to an ischemic third nerve palsy. (2) A 68-year-old woman who developed foot drop due to lumbosacral radiculopathy. (3) A 72-year-old man who developed arm weakness due to amyotrophic lateral sclerosis. (4) An 83-year-old man who developed leg weakness due to post-polio syndrome. (5) A 37-year-old woman who developed daytime fatigue due underlying sleep disorder. Conclusions: Patients with myasthenia gravis may develop other neurological disorders leading to weakness. If the diagnosis is not made accurately, patients may be exposed to procedures and treatments they may not need, which may even cause potential harm. Certain characteristics of myasthenia gravis, or its treatment, may, in fact, predispose patients to developing these conditions. The physician must maintain a high clinical suspicion for other neurological disorders, particularly when the patient’s symptoms or physical examination findings are not consistent with what would be expected from myasthenia gravis. Disclosure: Dr. Lewis has nothing to disclose. Dr. Granit has nothing to disclose. Dr. Benatar has served on the AveXis Scientific Advisory Board ($2,151), Genentech Honorarium as visiting speaker ($1,000) The University of Miami has received funding from Biogen ($50K) and Orphazyme ($40K) in support of my ALS research program.
Infectious Complications in Inflammatory Bowel Disease

Therapy for inflammatory bowel disease (IBD) has advanced significantly in recent years, allowing for better control of symptoms and improved quality of life for many patients. With better control, however, comes increased risk, as many newer therapies have profound effects on immune system function and therefore predispose to a wide variety of infectious complications. Herein we describe the newer therapies available for IBD and their mechanisms of action that may lead to increased risk of infection. We also detail potential infectious risks and how to anticipate and prevent them by utilizing historical information, screening mechanisms, and vaccination.
Abstract T P56: The Safety of Clopidogrel Loading Therapy in Acute Ischemic Stroke Patients with Chronic Hemorrhage on Gradient Echo MRI

Objective: To determine if an acute loading dose of clopidogrel is safe in acute ischemic stroke (AIS) patients with chronic intracerebral hemorrhage (ICH). Background: Clopidogrel loading is a promising therapy for AIS patients not eligible for tissue plasminogen activator (tPA) who are at risk for progressive stroke. Previous ICH is a risk factor for developing a new ICH. However, the acute risk of these events in this population after loading with clopidogrel has not been studied. Methods: We examined 1,011 AIS patients presenting to our center from 06/07/07-07/31/13. Only those loaded with at least 300mg of clopidogrel (with or without aspirin) within 6 hours of admission were analyzed. We compared new onset hemorrhagic complications in patients with and without chronic ICH, defined as areas of parenchymal hypodensity on gradient recall echo (GRE) sequencing on MRI. Repeat CT or MRI during admission was evaluated by a vascular neurologist for evidence of new ICH, hemorrhagic infarct using ECASS II criteria, or new ischemic infarct. Results: Of 365 AIS patients loaded with clopidogrel, 67 had chronic ICH on GRE. Patients with chronic ICH were more likely to be African American (80.0% vs. 65.9%, p=0.028) and male (69.2% vs. 50.9%, p=0.008). These patients were more likely to have existing comorbidities: history of stroke (67.7% vs 37.5%, p 2 on discharge, p=0.889), or unfavorable discharge disposition (defined as disposition other than home or inpatient rehabilitation, p=0.166). Conclusion: The presence of chronic ICH on GRE did not increase the risk of new ICH, hemorrhagic infarct, ischemic event, or neurologic deterioration after administration of an acute loading dose of clopidogrel for AIS.
Conjugacy, Self-Consistency and Bayesian Consensus

The notion of “conjugacy” has long been a staple of Bayesian inference, though the use of conjugate priors is much less prominent in current forms of Bayesian analysis than it was, say, twenty years ago. There are a number of reasons for the devaluation of conjugacy over the last two decades. The most obvious ones concern those associated with the major advances in Bayesian computation in the decade of the 1990s which have made possible the approximation of posterior distributions and related quantities for a broad array of prior models, rendering the use of priors which facilitate straightforward, closed-form posterior analysis less necessary, if still convenient. With the development and refinement of the Gibbs sampler and similar Markov chain Monte Carlo algorithms, one can now execute a well-approximated Bayesian analysis based on virtually any prior model.
Tissue Sites of Uptake of14C-Labeled C60

Abstract This paper describes thein vivobehavior and potential metabolism of C60and a more water-soluble quaternary ammonium salt-derivatized C60. In both cases, a14C-labeled fullerene core was utilized for the target molecules that were intravenously injected into female Sprague–Dawley rats. The14C-labeled C60(*C60) was rapidly (within 1 min) cleared from the circulation and the majority of the *C60accumulated in the liver (90–95%). *C60was not eliminated from the liver over the 120-h period of this study. Our results also suggest that C60is not metabolized by the typical oxidative patterns characteristic of other polycyclic aromatics. Therefore, although not acutely toxic, use of C60, or its derivatives that could be cleaved back to the parent C60in vivo, would likely lead to long-term fullerene accumulation in the liver. The uptake of *C60and14C-labeled ammonium salt-derivatized C60(1)by human keratinocytesin vitroshowed that while both *C60and1are readily taken up by cells,1accumulates more slowly. Additionally, while C60, at rather high concentrations (2.0 μ M ) and over extended periods of time (8 days), is able to inhibit the growth of human keratinocytes by about 50%, this effect showed little, if any, photoinducability.
Warfarin resistance: diagnosis and therapeutic alternatives

Warfarin resistance is a rare phenomenon, and most of the related literature obtained in a MEDLINE search from 1964-1995 consists of case reports. Warfarin resistance may develop as a result of noncompliance, exogenous consumption of vitamin K, and concurrent ingestion of other agents known to decrease warfarin's effects. There are three documented cases of hereditary resistance and one case of loose documentation of hereditary resistance with confirmation of similar resistant patterns in family members. Data on two of the three cases may support the postulation that hereditary resistance may be caused by the presence of an abnormal receptor or enzyme that has an increased affinity for vitamin K. To date, this receptor or enzyme has not been identified. To assess a subtherapeutic dose response to oral anticoagulation, the clinician must consider many possible causes of resistance, such as noncompliance, drug interactions, laboratory error, or pharmacokinetic changes. Once these have been ruled out, it is possible to consider that a tissue resistance to warfarin may be responsible.
A qualitative examination of content-based image retrieval behavior using systematically modified test images

We describe the outcome of an effort to understand the behavior of content-based image retrieval (CBIR) technology by examining the behavior of a CBIR system in response to carefully constructed input query images. This work is preliminary and only considers a single CBIR system, SIMPLIcity (J. Z. Wang et al. Proc. of First ACM/IEEE Joint Conf. on Digital Libraries, pp. 268-277, 2001). We chose this particular system for expediency. It is our intention to develop a methodology suitable for examining any CBIR system.