cssi/SciSciGPT-SciSciNet huggingface dataset:
Empowerment Evaluation, Postprofessionalization, and Oligarchy: A Retrospective

Here, I venture into the sociology of the professions to discuss the impact of empowerment evaluation on the autonomy of its practitioners. I do so because I found the process of conducting an empowerment evaluation to be challenging during the first four years of a Substances and Mental Health Services Administration (SAMHSA) system-of-care (SOC) mental health services transformation for youth with serious emotional disturbance (SED). My goal is to offer readers some suggestions about how to avoid these challenges in the future.
SWOT Analysis of the Comprehensive Prevention for Chronic Diseases in Communities in Minhang District of Shanghai

Strength-weakness-opportunity-threat (SWOT)analysis was used to reveal the future of the comprehensive prevention and control for chronic diseases in communities in Minhang District of Shanghai,and to provide reference for further development of the team of general practitioners.
Semantic evaluation as constraint network consistency

This paper investigates a problem of natural language processing from the perspective of reasoning work on constraint satisfaction. We formulate the task of computing singular, definite reference to a known contextual entity as a constraint satisfaction problem. We argue that such referential constraint problems have a structure which is often simpler than the general case, and can therefore often be solved by the sole use of low-power network consistency techniques. To illustrate, we define a linguistic fragment which provably generates tree-structured constraint problems. This enables us to conclude that the limited operation of strong arc consistency is sufficient to resolve the class of noun phrase defined by the fragment.
Mitochondria and Cancer

Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in stress sensing to allow for cellular adaptation to the environment. Therefore, it is not surprising that mitochondria are important mediators of tumorigenesis, as this process requires flexibility to adapt to cellular and environmental alterations in addition to cancer treatments. Multiple aspects of mitochondrial biology beyond bioenergetics support transformation, including mitochondrial biogenesis and turnover, fission and fusion dynamics, cell death susceptibility, oxidative stress regulation, metabolism, and signaling. Thus, understanding mechanisms of mitochondrial function during tumorigenesis will be critical for the next generation of cancer therapeutics.
Cyclic GMP-Mediated Signaling Mechanisms in Smooth Muscle

Publisher Summary Nitric oxide (NO) is an important cellular regulator that exerts major effects on processes as diverse as the regulation of vascular tone, and synaptic transmission and plasticity. Although NO—composed of only two atoms—is one of the simpler chemical structures in biology, its effects on cells are unusually complex. This chapter examines the most widely utilized NO signal transduction pathway, the cyclic GMP/cGMP-dependent protein kinase (PKG) system, in the regulation of smooth muscle tone. The role of PKG in smooth muscle is emphasized because this kinase is a critical control point for intracellular calcium regulation, contractile protein function, and gene expression. Special consideration is given to the pitfalls regarding interpretation of the published information from current studies.
What's Warren Buffett's Secret to Great Writing?

The gold standard in corporate communications is that of Warren Buffett’s letters to shareholders. When leaders of the National Association of Corporate Directors wanted to understand exactly why they are so valuable, they turned to Lawrence Cunningham, an incomparably informed and knowledgeable expert on the subject, having since 1995 been Buffett’s handpicked compiler and editor of The Essays Warren Buffett: Lessons for Corporate America. The editors of NACD’s quarterly, Directorship, published Cunningham’s article as their cover story in the summer of 2016. They explained: The legendary chair and CEO of Berkshire Hathaway has nearly perfected the art of writing his annual missive. We asked Lawrence A. Cunningham, the George Washington University professor who has worked with Buffett to both annotate and aggregate his letters, to share what makes this year’s example another standout. Here is Cunningham’s answer and complete analysis.
A Mathematician and an Artist. The Story of a Collaboration

In recent years it has become de rigueur for an invited speaker at a conference to “Thank the organizers for inviting me.” Today I can say this with more than the usual sincerity. Paris is my favorite city in the world, I have many fond memories of the Institut Henri Poincare, and the subject of this conference is very close to my heart. So to Claude, and all the organizers who have worked hard to make this conference a success. Merci bien.
Sanity tool: lightweight diagnostics for individual user accounts on supercomputer systems

It can be troublesome and challenging to diagnose and resolve problems caused by improper individual user account configurations on supercomputer systems. To assist individual users and those who support them in handling these issues efficiently and conveniently, we designed and created a new lightweight system utility named Sanity Tool. Sanity Tool includes a group of generic and machine-specific tests that are used to evaluate the correctness of a user's account configurations. It has played an important role in user support since its emergence on supercomputers at the Texas Advanced Computing Center (TACC). This tool can also be installed on almost any supercomputer system effortlessly, and it can be extended with customized site-specific tests with a reasonable amount of work.
A Note on Some Basic Concepts of the Sign

A conceptual basis for understanding meaning in language was established by Saussure’s analysis of the word as a sign in his Cours de Unguistique generale. His analysis has proved to be a point of departure for further studies in linguistics insofar as they are concerned with the signifying or semiotic function of language (rather than with problems that are principally philological, having to do with the historical development of particular languages). The contribution of Saussurian linguistics to epistemology has been enhanced by investigations in another discipline--philosophy--that have attempted to understand how words have meaning in ordinary language. This work originated with logical positivists in England and has since been pursued chiefly by English-speaking philosophers who are sometimes referred to as “ordinary language philosophers.” The best known of their publications is probably J.L. Austin’s How to do Things with Words. Put very simply, their investigations attempt to understand meaning in language by analyzing the word as a sign in the context of a given utterance.
The BLOC-1 Subunit Pallidin Facilitates Activity-Dependent Synaptic Vesicle Recycling.

Abstract Membrane trafficking pathways must be exquisitely coordinated at synaptic terminals to maintain functionality, particularly during conditions of high activity. We have generated null mutations in the Drosophila homolog of pallidin , a central subunit of the Biogenesis of Lysosome-related Organelles Complex 1 (BLOC-1), to determine its role in synaptic development and physiology. We find that Pallidin localizes to presynaptic microtubules and cytoskeletal structures, and that the stability of Pallidin protein is highly dependent on the BLOC-1 components Dysbindin and Blos1. We demonstrate that the rapidly recycling vesicle pool is not sustained during high synaptic activity in pallidin mutants, leading to accelerated rundown and slowed recovery. Following intense activity, we observe a loss of early endosomes and a concomitant increase in tubular endosomal structures in synapses without Pallidin. Together, our data reveals that Pallidin subserves a key role in promoting efficient synaptic vesicle recycling and re-formation through early endosomes during sustained activity. Significance Statement The speed and efficiency of synaptic vesicle recycling and re-formation are critical to maintain a functional synaptic vesicle pool during intense neuronal activity, yet the mechanisms that achieve this remain enigmatic. We show that the BLOC-1 component Pallidin promotes rapid and efficient synaptic vesicle recycling through endosomal intermediates. Further, Pallidin is necessary for the integrity of Rab5 positive synaptic endosomes during sustained neurotransmission.
The Impacts of Company Size on Leadership

This paper empirically tests the impacts of company size, measured by total sales revenues, on the importance of 12 essential leadership functions, (e.g., encouraging teamwork), six skills (e.g., interpersonal), seven traits (e.g., being decisive), four leadership styles - participatory, directive, tasks oriented, and employee oriented, and on leadership effectiveness. The findings evidence patterns of leadership at larger companies that are significantly different from smaller companies. The collective findings make a compelling argument that increasing company size reduces the importance of leaders engaging and interacting with followers. This likely reflects characteristics of larger companies that lessen the importance of or substitute for employee engagement and interpersonal interactions. However, the leadership at larger companies was not found to be less or more effective. The study also found that larger companies are more risk averse, which has additional implications for leadership. The findings have a number of implications for practitioners, researchers, and faculty teaching leadership.
Gpr126 Is Critical for Schwann Cell Function during Peripheral Nerve Regeneration.

Unlike their counterparts in the CNS, neurons in the peripheral nervous system (PNS) display a remarkable regenerative capacity following injury largely due to Schwann cell (SC) activity, which provides critical support for growth and repair ([Fig. 1][1]). After injury (e.g., when the axon is cut or
Socially‐Aware Cooperative D2D and D4D Communications toward Fog Networking

This chapter aims at boosting the network bandwidth by promoting collaborative communications between handheld devices at the network edge by using the principle of fog networking. Such device‐to‐device (D2D) and device‐for‐device (D4D) communications can offer a variety of advantages over traditional cellular communications, such as higher user throughput, improved spectral efficiency, and extended network coverage. The chapter proposes a novel social trust and social reciprocity‐based framework to promote efficient cooperation among devices for cooperative D2D and D4D communications‐based fog networking. It introduces the physical‐social graphs to model the interplay therein while capturing the physical constraints for feasible D2D cooperation and the social relationships among devices for effective cooperation by projecting D2D communications in a mobile social network onto both physical and social domains. The chapter formulates the relay selection problem for social trust and social reciprocity‐based cooperative D2D communications as a coalitional game. It develops a network‐assisted mechanism to implement the coalitional game‐based solution.
A Model of Transfer Pricing Conflicts Between Revenue Canada and the Internal Revenue Service

Although both Canada and the United States use the ?arm?s length standard? when evaluating transfer prices for tax purposes, they disagree over which transfer pricing methods are acceptable. Both countries accept methods based on comparable transactions and gross margins of comparable products. The U.S. also accepts, and may in practice prefer, methods based on net profits of comparable firms. Canada resists using the comparable profit method. This paper examines the effects of the various transfer pricing methods on the allocation of taxable income in a model in which organization structure affects the level of relationship-specific investments made by vertically integrated groups and comparable independent firms. Analysis of the model shows that the five transfer pricing methods considered are not equivalent. The comparable profit method allocates less income to Canada in cases involving U.S. parents and Canadian subsidiaries, and in cases in which more reliable gross margin data is available for U.S. firms than for Canadian firms.
DMD and POD of time-resolved schlieren on a multi-stream single expansion ramp nozzle

Abstract Time-resolved schlieren measurements were conducted on a supersonic rectangular multi-stream nozzle used for three-stream engines. The jet utilizes a single expansion ramp nozzle (SERN) configuration along with an bypass stream, operating at an ideally expanded bulk flow of M j , 1 = 1.6 and bypass stream of M j , 3 = 1.0 . Experiments were conducted with and without an aft deck to model airframe integration. Schlieren imaging was acquired up to 100 kHz in two different orientations. Proper orthogonal decomposition (POD) and dynamic mode decomposition (DMD) were applied to the schlieren data to identify flow structures. Comparisons were made between the two decomposition methods in the form of spatial correlations.
Transgenic drosophila as a drug-screening platform in colorectal cancer and medullary thyroid cancer.

e23164Background: Solid tumors are typically driven by genetic changes in multiple signaling pathways. While drugging single “actionable” targets can be effective, this approach fails to address tu...
IMPACT OF NO-COST CORONARY CALCIUM SCORE TESTING IN PATIENTS AT RISK FOR CARDIOVASCULAR DISEASE ON PATIENT REPRESENTATION AND DIAGNOSTIC YIELD

Despite the exceptional performance of coronary artery calcium scoring (CACS) testing in risk stratification, its utilization in clinical practice has been hampered by financial barriers including restricted coverage by insurance. We sought to identify the impact the introduction of no-cost CACS
New Directions in Graph Theory (With an Emphasis on the Role of Applications)

Abstract We summarize some general themes which we saw as coming out of Quo Vadis Graph Theory? — an international conference on the future of graph theory, held at the University of Alaska, Fairbanks, in August 1990. We expand on these themes with specific examples and emphasize the role of applications.
On Bob Dylan’s Nobel speech: sound, medium and genre

To the surprise of exactly no one, Bob Dylan took his time responding publicly to the news that he had won the Nobel Prize in Literature. The announcement – delivered by Sara Danius, then the Perma...
Chapter 64 – Immunodeficiency and Mucosal Immunity

This chapter outlines the information about gastrointestinal conditions. Secretory IgA (S-IgA) binds commensal flora and other intestinal antigens and is considered an important part of the T-cell-independent mucosal immune system. This antibody is produced in great abundance and has a complex synthetic and secretory pathway. IgA deficiency is the most common primary immune deficiency disease of humans. The lack of S-IgA leads to a variety of infections and inflammatory conditions, but for each deficiency disease the manifestations vary. Whatever genetic abnormality may underlie IgA deficiency, it is not always a stable defect, since IgA deficiency can disappear spontaneously, can be induced by viral infections, and can be caused by a number of disparate drugs such as—phenytoin, penicillamine, captopril, and Tegretol. Males with X-linked gammaglobulinemia (XLA) have an excellent T-cell immunity, whereas subjects with common variable immunodeficiency disease (CVID) usually have T-cell defects. Studies in knockout mice indicate an essential role for T cells and cytokine regulation in intestinal mucosal integrity. It is the lack of these regulatory factors that predisposes patients with CVID to inflammatory mucosal diseases.
Feasibility and efficacy of a novel technology-based approach to harness social networks for weight loss: the NETworks pilot randomized controlled trial.

Objective Harnessing social support from existing social ties represents a key weight control practice. This trial evaluated an intervention that provided health-promoting technologies for leveraging the influence of existing social ties. Methods Volunteers (N = 36) with a body mass index between 25 and 55 kg m-2 were randomized to a 16-week, in-person, technology-supported behavioural weight-loss treatment (standard behavioural treatment) or the same programme supplemented by providing self-selected members of participants' social networks with a digital body-weight scale and Fitbit Zip physical activity tracker (ENHANCED). Results Average weight losses from baseline to 16 weeks did not significantly differ between groups (standard behavioural treatment, 5.30%, SD =3.93%; ENHANCED, 5.96%, SD = 5.19%, p = 0.63). By the 1-year follow-up, standard behavioural treatment had lost 5.63%, SD = 8.14% of baseline weight versus 4.73%, SD = 9.43% for ENHANCED (p = 0.82). ENHANCED reported self-weighing on more days than did standard behavioural treatment (p = 0.03). Most participants reported high programme satisfaction. Similar improvements were observed in perceived social support for diet and exercise from baseline to 16 weeks in both groups (ps < 0.05) but regressed by 1 year (ps < 0.01). Conclusion Although feasible to implement, this technology-based, social support approach failed to enhance outcomes of a face-to-face, group-based behavioural weight-loss treatment.
Total Synthesis of Ciliatamides A–C: Stereochemical Revision and the Natural Product-Guided Synthesis of Unnatural Analogs

The first total synthesis of Ciliatamides A-C was completed, leading to a revision of the reported stereochemistry from (S,S) to the (R,R) enantiomers. Due to the expedited route, a library of over 50 unnatural ciliatamide analogs was also prepared.
Analysis of Equilibria in the Extraction of Cesium Nitrate by Calix[4]arene-bis(t-Octylbenzo-Crown-6) in 1,2-Dichloroethane

The extraction of CsNO3 by the highly lipophilic calixarene-crown ether calix[4]arene-bis(t-octylbenzo-crown-6) (CABOBC6) in 1,2-dichloroethane (1,2-DCE) at 25 °C has been shown to be consistent with the formation of both 1 : 1 and 2 : 1 metal : ligand species. Variation of the aqueous-phase CsNO concentration up to 1.0 M and variation of the organic-phase calixarene concentration up to 0.10∼M was modeled by the program SXLSQI. Formation of the organic-phase species CsBNO3 (B = calixarene) was confirmed as well as the organic-phase dissociation products CsB+ and NO3-. Good evidence for the 2 : 1 metal : ligand organic-phase species Cs2B(NO3)2 was also found, although the dissociation of nitrate from this complex was not observed. Binding of the second Cs+ cation by the ligand is approximately two orders of magnitude weaker than binding of the first Cs+ cation. The logarithm of the apparent partition ratio (log PB) of the calixarene between water and 1,2-DCE was found by 1H-NMR techniques to be > 5.1.
Toward an operant model of power in organizations.

The purpose of this paper is to suggest that behavior analysis can help to explain social power. In this approach, an individual’s potential for influence is thought to be partially a function of his or her access to stimuli that can be used as consequences. This access can occur either through direct authority or indirectly through social networks and exchanges. Social power is also thought to be a function of an individual’s skill in delivering the stimuli in ways that will have the most impact on behavior. A number of predictions about power based on an operant approach are offered.
31 Reducing variability in discharge communication reduces administrative burden

Background Streamlined discharge communication in transitions of care improvement models improve patient satisfaction, improve patient self-efficacy, and reduce readmissions. Yet, significant variability and quality exists in the After Visit Summary (AVS) which is used to guide the post-discharge needs of the patient. Objectives We sought assess the feasibility, fidelity, acceptability, and effectiveness of a standardized, patient-centered AVS. Methods Our multiprofessional and multidisciplinary stakeholder team was led by two physicians and had significant institutional support. We employed a tailored, hybrid implementation strategy, blending components from Lean methodology, the Institute for Healthcare Model for Improvement, and the Consolidated Framework for Implementation Research. We assessed the feasibility (e.g. quality of AVS, usability of template), fidelity (e.g. template utilization rates), acceptability (e.g. direct stakeholder feedback, paging-system audit, patient call logs), and effectiveness (e.g. 30-day readmission rates and patient-centeredness) of our intervention (e.g. standardized, patient-centered AVS). Results Our AVS template was written at a third grade reading level but retained all clinically-relevant information. Providers and patients approved of the template with 66% mean utilization (range 41% to 80%). After our intervention, we observed decreased 30-day readmissions (19.7% to 16.0%). Notably, after the introduction of AVS template, pages sent decreased by 3.67 pages weekly (95% CI=[−15.7, 14.0]), but this estimate was imprecise. Conclusions Reducing variability and improving the quality of discharge communication, not only improves patient outcomes, but may also improve workflow for providers. These improved team dynamics are important to assess when considering an intervention that is operationalized by time and resource deprived employees.
NATIONAL GENDER-BASED IN-HOSPITAL MORTALITY AND OUTCOME IN PATIENTS WITH LEFT VENTRICULAR ASSIST DEVICE: 2008-2014 NATIONAL INPATIENT SAMPLE TREND ANALYSIS

Congestive heart failure (CHF) affects 2.4% of the population in the United States. Left ventricular assist devices (LVADs) is a lifesaving therapy for end-stage heart failure patient waiting for a transplant or are not a candidate for a heart transplant. LVADs have shown reduced mortality and
Editorial Commentary: How Do We Assess Graft Status After Superior Capsule Reconstruction?

Abstract Superior capsule reconstruction for the treatment of irreparable rotator cuff tears leads to improvement in function. However, a substantial portion of grafts are not intact postoperatively. There is no consensus on the adequate timing of postoperative magnetic resonance imaging for the assessment of graft status. More studies are needed to understand the patient and surgical factors associated with graft integration.
Effect of Gaze Direction on Evaluation of Visually Impaired Children by Informed Respondents

Fifty subjects concerned and in continual interaction with visually impaired individuals were randomly assigned to view one of two videotapes. The tapes showed two visually impaired children withou...
Human cord blood-derived regulatory T-cell therapy modulates the central and peripheral immune response after traumatic brain injury

Traumatic brain injury (TBI) causes a profound inflammatory response within the central nervous system and peripheral immune system, which contributes to secondary brain injury and further morbidity and mortality. Preclinical investigations have demonstrated that treatments that downregulate microglia activation and polarize them toward a reparative/anti-inflammatory phenotype have improved outcomes in preclinical models. However, no therapy to date has translated into proven benefits in human patients. Regulatory T cells (Treg) have been shown to downregulate pathologic immune responses of the innate and adaptive immune system across a variety of pathologies. Furthermore, cellular therapy has been shown to augment host Treg responses in preclinical models; yet, studies investigating the use of Treg as a therapeutic for TBI are lacking. In a rodent TBI model, we demonstrate that human umbilical cord blood Treg modulate the central and peripheral immune response after injury in vitro and in vivo.
Role of GPRC6A in Regulating Hepatic Energy Metabolism in Mice

GPRC6A is a widely expressed G-protein coupled receptor that regulates energy metabolism. Global deletion of Gprc6a in mice is reported to result in a metabolic syndrome-like phenotype and conditional deletion of Gprc6a in pancreatic β-cell and skeletal muscle respectively impair insulin secretion and glucose uptake. In the current study, we explore the hepatic functions of GPRC6A by conditionally deleting Gprc6a in hepatocytes by cross breeding Alb-Cre and Gprc6aflox/flox mice to obtain Gprc6aLiver-cko mice. Gprc6aLiver-cko mice on a normal diet showed excessive hepatic fat accumulation and glycogen depletion. These mice also exhibit impaired glucose and pyruvate tolerance, but normal insulin sensitivity. Decreased circulating FGF-21 levels and FGF-21 message expression in the liver were found in Gprc6aLiver-cko mice. Hepatic transcriptome analysis identified alterations in multiple pathways regulating glucose, fat and glycogen metabolism in Gprc6aLiver-cko mice. Taken together, our studies suggest that GPRC6A directly regulates hepatic metabolism as well as regulates the production and release of FGF-21 to control systemic energy homeostasis. GPRC6A's unique regulation of β-cell, skeletal muscle and hepatic function may represent a new therapeutic target for treating disordered energy metabolism metabolic syndrome and type 2 diabetes.
Metamorphic Proteins in light of the Anfinsen Dogma

It is a common belief that metamorphic proteins challenge the Anfinsen thermodynamic hypothesis (or dogma). Here we argue against this view aims to show that metamorphic proteins not just fulfill the Anfinsen dogma but also exhibit marginal stability comparable to that seen on macromolecules and macromolecular complexes. This work contributes to our general understanding of protein classification and may spur significant progress in our effort to analyze protein evolvability.
Cause-Specific Mortality Following Initial Chemotherapy in a Population-Based Cohort of Patients With Classical Hodgkin Lymphoma, 2000-2016

PURPOSEMortality for patients with classical Hodgkin lymphoma (cHL) treated during an era characterized in the United States by widespread use of doxorubicin, bleomycin, vinblastine, and dacarbazin...
Beyond The Text: Analysis of Privacy Statements through Syntactic and Semantic Role Labeling.

This paper formulates a new task of extracting privacy parameters from a privacy policy, through the lens of Contextual Integrity, an established social theory framework for reasoning about privacy norms. Privacy policies, written by lawyers, are lengthy and often comprise incomplete and vague statements. In this paper, we show that traditional NLP tasks, including the recently proposed Question-Answering based solutions, are insufficient to address the privacy parameter extraction problem and provide poor precision and recall. We describe 4 different types of conventional methods that can be partially adapted to address the parameter extraction task with varying degrees of success: Hidden Markov Models, BERT fine-tuned models, Dependency Type Parsing (DP) and Semantic Role Labeling (SRL). Based on a detailed evaluation across 36 real-world privacy policies of major enterprises, we demonstrate that a solution combining syntactic DP coupled with type-specific SRL tasks provides the highest accuracy for retrieving contextual privacy parameters from privacy statements. We also observe that incorporating domain-specific knowledge is critical to achieving high precision and recall, thus inspiring new NLP research to address this important problem in the privacy domain.
Untwist the twist: instant hemodynamic improvement in known HeartMate 3 complication

The HeartMate 3 [HM3 (Abbott, Abbott Park, Illinois)] is a left-ventricular assist device (LVAD) with excellent clinical results. Outflow graft occlusion as a complication secondary to outflow graft twisting was reported to occur in 1.6% within the MOMENTUM 3 trial. The anti-twist metal clip or modified bend relief is made to prevent this complication currently, however, there remain large numbers of early implanted HM3 which may develop this complication. There are limited reports illustrating diagnosis, surgical repair, and post-repair hemodynamic changes of these complications. Thus, we present a case of successful diagnosis and surgical repair of an outflow graft twist. Simple procedure through thoracotomy without cardiopulmonary bypass provides significant immediate hemodynamic improvement.
Unravelling The Immune Modulatory Effect Of Indian Spices To Impede The Transmission Of Covid-19: A Promising Approach.

Months after WHO declared COVID-19 as a Global Public Health Emergency of International Concern, it does not seem to be flattening the curve as we are still devoid of an effective vaccine and treatment modality. Amid such uncertainty, being immune is the best strategy to defend against corona attack. As the whole world is referring back to immune-boosting grandma remedies, interest is rekindled in the Indian system of Medicine, which is gifted with an abundance of herbal medicines as well as remedies. Among them, spices (root, rhizome, seed, fruit, leaf, bud, and flower of various plants used to add taste and flavors to food) are bestowed with immense medicinal potential. A plethora of clinical as well as preclinical studies reported the effectiveness of various spices for various ailments. The potential immune-boosting properties together with its excellent safety profile are making spices the current choice of Phyto-research as well as the immune-boosting home remedies during these sceptical times. The present review critically evaluates the immune impact of various Indian spices and their potential to tackle the novel coronavirus, with comments on the safety and toxicity aspects of spices.
Bayesian Time-Series Analysis to Predict Real-Time Smart Grid Energy Price Uncertainty

The prediction of the real-time (RT) electricity prices in the smart grids is one of the challenging problems for electricity producers as well as consumers. To participate in smart grids RT electricity market, it is essential to predict the uncertainty inherent in price values caused by data collection and analysis methods and conduct risk analysis. In this paper, using the Auto-regressive Integrated Moving-Average (ARIMA) formulation of time-series, first a deterministic model of RT price is developed. Then, using Bayesian theorem and considering stochastic behavior of the prices, a stochastic ARIMA model to predict price uncertainty is presented. To obtain RT price posterior distribution, two different Bayesian statistical approaches are used and compared against each other. The first approach is direct Bayesian modeling using Hamilton Monte Carlo Markov Chain (HMCMC) sampling and the second method is Variational Bayesian (VB) Inference. Both methods are implemented on the New England Independent System Operator (ISO) public price dataset. The results confirm the solidness of proposed method to obtain price uncertainty and optimal confidence intervals.
A mechanical model for magnetized relativistic blastwaves

The evolution of a relativistic blastwave is usually delineated under the assumption of pressure balance between forward- and reverse-shocked regions. However, such a treatment usually violates the energy conservation law, and is inconsistent with existing MHD numerical simulation results. A mechanical model of non-magnetized blastwaves was proposed in previous work to solve the problem. In this paper, we generalize the mechanical model to the case of a blastwave driven by an ejecta with an arbitrary magnetization parameter $\sigma_{\rm ej}$. We test our modified mechanical model by considering a long-lasting magnetized ejecta and found that it is much better than the pressure-balance treatment in terms of energy conservation. For a constant central engine wind luminosity $L_{\rm ej} = 10^{47}{\rm erg~s^{-1}}$ and $\sigma_{\rm ej} < 10$, the deviation from energy conservation is negligibly small at small radii, but only reaches less than $25\%$ even at $10^{19}{\rm cm}$ from the central engine. For a finite life time of the central engine, the reverse shock crosses the magnetized ejecta earlier for the ejecta with a higher $\sigma_{\rm ej}$, which is consistent with previous analytical and numerical results. In general, the mechanical model is more precise than the traditional analytical models with results closer to those of numerical simulations.
The Diagnostic Value of Plasma miRNA-497, cTnI, FABP3 and GPBB in Pediatric Sepsis Complicated with Myocardial Injury.

Objective To investigate the diagnostic value of plasma miRNA-497, cardiac troponin I (cTnI), fatty acid binding protein 3 (FABP3), glycogen phosphorylase isoenzyme BB (GPBB) in pediatric sepsis complicated with myocardial injury. Methods From August 2018 to February 2020, 82 children with sepsis admitted to our hospital and 50 health children who came for physical examination (defined as control group) were enrolled in this study. Children with sepsis and myocardial injury were enrolled in the combined group (n=35), and those without myocardial injury were enrolled in the sepsis group (n=47). General data of three groups were collected, and the levels of miRNA-497, FABP3, GPBB, creatine kinase isoenzyme MB (CK-MB), procalcitonin (PCT), C-reactive protein (CRP), cTnI and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were detected and the cardiac function was measured. The diagnostic value of plasma miRNA-497, cTnI, FABP3 and GPBB in pediatric sepsis complicated with myocardial injury was analyzed. Results The infection site of the combined group was not significantly different from that of the sepsis group. The levels of miRNA-497, FABP3, GPBB, CK-MB, PCT, CRP, cTnI, NT-proBNP in the combined group were all higher than those in the sepsis group and the control group (P 0.05). When the optimal thresholds of miRNA-497, FABP3, GPBB, and cTnI were set to 2.03, 6.23ng/mL, 4.01ng/mL, 1.23ng/mL, respectively, the sensitivity was 95.65%, 88.89%, 82.61%, 87.50%, respectively; the specificity was 83.33%, 94.12%, 83.33%, 90.91%, respectively; and the accuracy was 91.43%, 91.43%, 82.86%, 88.57%, respectively. Pearson correlation analysis indicating that miRNA-497 was positively correlated with the levels of FABP3, GPBB, and cTnI in the combined group (r=0.821, 0.621, 0.782, P Conclusion Plasma miRNA-497, cTnI, FABP3, and GPBB levels were increased in pediatric sepsis complicated with myocardial injury, and their combination had high diagnostic value, which was of great clinical significance for early diagnosis and early treatment of pediatric sepsis complicated with myocardial injury.
Dealing with “Dilemmas of Difference” in the Workplace

Over the course of six months, the University of Pennsylvania Carey Law School’s class “Women, Law, and Leadership” interviewed 55 women between the ages of 25 and 85, all leaders in their respective fields. Nearly half of the women interviewed were women of color, and 10 of the women lived and worked in countries other than the U.S., spanning across Europe, Africa, and Southeast Asia. Threading together the common themes touched upon in these conversations, we gleaned a number of novel insights, distinguishing the leadership trajectories pursued by women who have risen to the heights of their professions. Through thousands of hours of conversation with some of the world’s most influential and powerful women, this study identifies the primary barriers and biases faced by women of diverse backgrounds in the workplace, as well as the strategies and philosophies they adopted in order to overcome these impediments. While there is much commonality among the women’s experiences, women of color often face more pervasive and subtle barriers than their white counterparts. Their leadership strategies on how to address these insidious challenges, however, are rarely recorded. In this article, we give voice to these experiences.
Examining performance and likelihood ratios for two likelihood ratio systems using the PROVEDIt dataset.

A likelihood ratio (LR) system is defined as the entire pipeline of the measurement and interpretation processes where probabilistic genotyping software (PGS) is a piece of the whole LR system. To gain understanding on how two LR systems perform, a total of 154 two-person, 147 three-person, and 127 four-person mixture profiles of varying DNA quality, DNA quantity, and mixture ratios were obtained from the filtered (.CSV) files of the GlobalFiler 29 cycles 15s PROVEDIt dataset and deconvolved in two independently developed fully continuous programs, STRmix v2.6 and EuroForMix v2.1.0. Various parameters were set in each software and LR computations obtained from the two software were based on same/fixed EPG features, same pair of propositions, number of contributors, theta, and population allele frequencies. The ability of each LR system to discriminate between contributor (H1-true) and non-contributor (H2-true) scenarios was evaluated qualitatively and quantitatively. Differences in the numeric LR values and their corresponding verbal classifications between the two LR systems were compared. The magnitude of the differences in the assigned LRs and the potential explanations for the observed differences greater than or equal to 3 on the log10 scale were described. Cases of LR 1 for H2-true tests were also discussed. Our intent is to demonstrate the value of using a publicly available ground truth known mixture dataset to assess discrimination performance of any LR system and show the steps used to understand similarities and differences between different LR systems. We share our observations with the forensic community and describe how examining more than one PGS with similar discrimination power can be beneficial, help analysts compare interpretation especially with low-template profiles or minor contributor cases, and be a potential additional diagnostic check even if software in use does contain certain diagnostic statistics as part of the output.
The Brand X Constitution

Scholars from across the political spectrum have in recent years attacked the Supreme Court's claim to supreme power to interpret the Constitution. This Article adds to this movement of "popular constitutionalism" by deploying the Supreme Court's own doctrine against it. Recent developments in the Chevron doctrine have culminated in what might be called, after the case that gave it form, the Brand X model of statutory interpretation. Broadly speaking, this model requires courts to uphold an agency's reasonable interpretation of a statute it administers - even in the teeth of contrary precedent - so long as the agency used transparent, deliberative means to adopt it. Translating this Brand X model into a constitutional setting, this Article claims that courts should uphold reasonable legislative constitutional constructions that are expressly stated in focused federal legislation even if they contradict contrary Supreme Court precedent. This proposal would thus require the Supreme Court to extend about as much deference to select legislative precedents as it now indulges its own judicial precedents. Adopting this approach would expand in an incremental and controlled way the voice of the public, Congress, and the President in constitutional construction. The most fundamental reason to pursue this change is that choosing among reasonable constitutional constructions is a political task that depends on value judgments and related assessments of legislative fact. In a representative democracy, the problem of making such policy choices should be committed ultimately to public judgment rather than nine life-tenured judges.
Envisioning the future of cultural neuroscience

In the present commentary, we first examine the three target articles included in the Asian Journal of Social Psychology special issue on cultural neuroscience. We spell out the contributions that the articles have offered to the field. We extend this examination with our own theoretical model of neuro-culture interaction, which proposes that brain connectivity changes as a function of each person's active, repeated engagement in culture's scripted behavioural patterns (i.e. practices). We then locate the current endeavour of cultural neuroscience within a broader framework, detailing empirical, theoretical, and meta-theoretical reasons why the approach of cultural neuroscience is important to both socio-behavioural and biological sciences. It is concluded that the scholarship demonstrated in the target articles will be an important collective asset for all of us who aspire to understand the human mind as fundamentally biocultural and to study it as such.
Trying a New Way: Barack Obama's Tolerance of Intolerance

This thought-piece concerns Barack Obama’s choices for the three highest-profile ministers during his inauguration weekend, namely Gene Robinson, the deeply spiritual, openly-gay, white Episcopal bishop; Rick Warren, the conservative, anti-gay, white mega-church pastor; and Joseph Lowery, the black civil rights icon and supporter of gay rights. As a very complex script about religion, sexuality, and race, Obama’s presentation of this particular line-up can be read to propose (1) religious affirmation of the full personhood of gays and lesbians (given inclusion of Robinson and Lowery); (2) gay rights as civil rights (which is one aspect of what Lowery stands for); and (3) religious tolerance, suggesting that conservative Christians, like Rick Warren, loosen their sectarianism and that religious liberals be more respectful of conservatives, like Rick Warren. Because the choice of Rick Warren to deliver the invocation garnered enormous media attention, this essay begins with an inquiry into the theological meaning of a liberal’s decision to include a conservative in the inaugural rites. Then, the analysis shifts to Robinson and Lowery, with whom the mainstream media were less concerned, but who might be of particular interest to Critical Race Theory because of the challenges posed by Robinson and Lowery to religious conservatives, particularly conservative African Americans. Barack Obama's invitation to Rick Warren might be a partial, tentative response to the following question: how far can progressives and liberals
Control of arthritis associated with congenital agammaglobulinemia by high doses of exogenous gamma globulin.

Reports about the response of arthritis associated with agammaglobulinemia to conventional amounts of exogenous γ-globulin have been controversial.1-3 It appears from some of these reports3 that more intensive therapy with exogenous γ-globulin is required for accomplishing remission of joint symptoms that is necessary for control of infections. Pabst and Gelpke (Pediatrics 61:306, 1978) suggested that a certain level of serum IgG should be achieved and maintained for remission. We report similar results in one of our patients with arthritis and congenital agammaglobulinemia.
Robin Hood: Anthology of Scholarship and Criticism

Reviewed Medium: book Year: 1999 Pages: xx. + 467 Publisher: Boydell and Brewer ISBN: 0859915255 (hard cover). Prices: $135.00(hard cover).
Leakage in nanometer scale CMOS circuits

High leakage current in deep sub-micron regimes is a significant contributor to the power dissipation of CMOS circuits as the CMOS technology scales down. Consequently, the identification and modeling of different leakage components is very important for estimation and reduction of leakage power, especially for low power applications. This paper explores transistor leakage mechanisms and device and circuit techniques to reduce leakage power consumption.
Geographical variation in morphology and its environmental correlates in a widespread North American lizard, Anolis carolinensis (Squamata: Dactyloidae)

The green anole, Anolis carolinensis, has long been an important model organism for studies of physiology and behaviour, and recently became the first reptile to have its genome sequenced. With a large and environmentally heterogeneous distribution, especially in relation to well-studied Antillean relatives, A. carolinensis is also emerging as an important organism for novel studies of geographical differentiation and adaptation. In the present study, we quantify the degree of morphological variation in this species and test for environmental correlates of this variation. We also examine adherence to Bergmann's and Allen's rule, two eco-geographical principles that have been well studied over large species ranges. We sampled from 14 populations across the distribution of the species in North America and measured 28 distinct morphological traits. We also collected a suite of environmental variables for each site, including those related to temperature, precipitation, and vegetation. Ultimately, we found a large degree of geographical variation in morphology, with head traits contributing the most to differences among populations. Morphological variation was correlated with variation in temperature, precipitation, and latitude across sites. We found no support for reverse Bergmann's rule typical of squamates, although we did find a trend of reverse Allen's rule. Ultimately, the present study provides a novel look at A. carolinensis and establishes it as a strong candidate for further studies of variation and adaptation over a large range.
Nonideal quantum detectors in Bayesian formalism

The Bayesian formalism for a continuous measurement of solid-state qubits is extended to a model which takes into account several factors of the detector nonideality. In particular, we consider additional classical outputand backaction noises (with finite correlation), together with quantum-limited output and backaction noises, and take into account possible asymmetry of the detector coupling. The formalism is first derived for a single qubit and then generalized to the measurement of entangled qubits.
Fast stochastic MPC with optimal risk allocation applied to building control systems

This paper presents a method for solving linear stochastic model predictive control (SMPC) subject to joint chance constraints. The chance constraints are decoupled using Boole's inequality and by introducing a set of unknowns representing allowable violation for each constraint (the risk). A tailored interior point method is proposed to explore the special structure of the resulting SMPC problem. The proposed method is compared with existing two-stage algorithms with the first stage allocating the risks and the second stage optimizing the feedback control gain. The approach is applied to building control problems that minimizes energy usage while keeping thermal comfort by making use of uncertain predictions of thermal loads and ambient temperature. Extensive numerical tests show the effectiveness of the proposed approach.
Interaction of alpha and beta adrenergic stimulation on aortic ornithine decarboxylase activity.

Abstract The interaction between beta and alpha adrenergic agonists on regulation of cockerel aortic ornithine decarboxylase (ODC) activity was examined. The beta adrenergic agonist isoproterenol both reduced basal aortic ODC activity and prevented induction of the decarboxylase by the alpha adrenergic agonist methoxamine. 3-Isobutyl-1- methylxanthine (IBMX) similarly reduced basal ODC activity and blocked induction of the enzyme by methoxamine. When given ten minutes before or after methoxamine, isoproterenol prevented aortic ODC induction, but not large sustained increases in blood pressure evoked by the alpha adrenergic agonist. In contrast, when injected three hours after methoxamine, isoproterenol had no effect on already elevated levels of enzyme activity. Addition of isoproterenol (10 −7 M), IBMX (1 mM) or dibutyryl cAMP (2.5 mM) to isolated aortic segments cultured in minimal salts-glucose media evoked decreases in basal levels of ODC activity resembling those observed in the intact animal. These results suggest that the balance between alpha and beta adrenergic stimulation may be an important feature of the regulation of polyamine biosynthesis in artery wall cells.