cssi/SciSciGPT-SciSciNet huggingface dataset:
Spatiotemporality, Anthonomasia, and Post-Qualitative Inquiry:

Although many qualitative researchers have rejected modernism as a guiding theoretical framework, they continue to work within a space/time binary. Space and time represent two of our most fundamental concepts, and the associated binary operates essentially unquestioned. The concepts of spacing, temporalizing, and spatiotemporality are introduced to show how time is irremediably contaminated by space and vice versa. A strange space is opened up by the deconstruction of space and time, one in which every “now” is also a “point” and every “point” is also a “now.” This properly differential and original space constitutes one important aspect of a post-qualitative inquiry. Derrida’s work, Glas, is then introduced as an example of a text in which a spatiotemporal reinscription is attempted. Anthonomasia as a writing strategy is then discussed as a way in which a spatiotemporal reinscription can occur more deliberately. Examples are also presented to illustrate this writing strategy.
Recovery sleep and performance following sleep deprivation with dextroamphetamine

Twelve subjects were studied to determine the after-effects of using three 10-mg doses of dextroamphetamine to sustain alertness during sleep deprivation. Sleep architecture during recovery sleep was evaluated by comparing post-deprivation sleep beginning 15 h after the last dextroamphetamine dose to post-deprivation sleep after placebo. Performance and mood recovery were assessed by comparing volunteers who received dextroamphetamine first (during sleep deprivation) to those who received placebo first. Stages 1 and 2 sleep, movement time, REM latency, and sleep latency increased on the night after sleep deprivation with dextroamphetamine vs. placebo. Stage 4 was unaffected. Comparisons to baseline revealed more stage 1 during baseline than during either post-deprivation sleep period and more stage 2 during baseline than during sleep following placebo. Stage 4 sleep was lower during baseline than it was after either dose, and REM sleep was lower during baseline and after dextroamphetamine than after placebo. Sleep onset was slowest on the baseline night. Next-day performance and mood were not different as a function of whether subjects received dextroamphetamine or placebo during deprivation. These data suggest dextroamphetamine alters post-deprivation sleep architecture when used to sustain alertness during acute sleep loss, but next-day performance and subjective mood ratings are not substantially affected. A recovery sleep period of only 8 h appears to be adequate to regain baseline performance levels after short-term sleep deprivation.
Differential pulse voltammetry with medium-exchange for analytes strongly adsorbed on electrode surfaces

Abstract Differential pulse voltammetry with medium-exchange is employed for selective and sensitive measurements of electroactive species strongly adsorbed on electrode surfaces. In order to minimize interferences resulting from macro solution constituents, the working electrode is transferred into a electrolyte solution possessing ideal background characteristics following the preconcentration/adsorption step. The increased selectivity obtained by making the measurement in the solution is demostrated by the determination of the adsorbable species in the presence of 10 3 –10 4 -fold excess of a solution species with similar redox potential. Illustrative voltammograms of chlorpromazine in blood and urine are presented.
Digital Object Identifiers and Their Use in Libraries

Digital Object Identifiers (DOIs) are persistent identifications that are assigned to any entity in order to manage intellectual content on digital networks. The DOI system has been managed by an open membership consortium, the International DOI Foundation (IDF), founded in 1998. Usage of the DOI system is cross-industry beyond academic publishing. This article provides an overview of what a DOI is; the structure of DOI; DOI registration agencies (RA); metadata associated with DOIs, and advantages for libraries.
Experimental investigation of simultaneous creep, plasticity and transformation of Ti50.5Pd30Ni19.5 high temperature shape memory alloy during cyclic actuation

Abstract The influence of inelastic phenomena (i.e. plasticity and viscoplasticity) on the phase transformation and the cyclic actuation behavior of a Ti50.5Pd30Ni19.5 high temperature shape memory alloy (HTSMA) was investigated by thermomechanical testing. Standard creep and constant stress thermal cycling experiments were conducted to study the rate-independent and rate-dependent irrecoverable strain generation both individually and simultaneously with the phase transformation. Based on a preliminary power-law fit of the creep data from the creep tests, the varying creep rates and stress exponents suggest that the mechanism for creep deformation changes with both stress level and temperature within the likely operating range for the alloy. The load-biased thermal cycling tests show that the material performance can be significantly affected by rate independent plasticity strains generated during transformation, rate dependent viscoplastic strains as well as factors such as retained martensite accumulation. To consolidate these inelastic mechanisms, a combined phase transformation–deformation diagram was constructed to show the phase transformation along with the plastic and viscoplastic regions within the operational range of the HTSMA.
A valence bond theory of off-center impurities in silicon

Abstract We present the first cluster calculations which explicitly include electronic correlation effects in the study of impurities in Si (e.g., nitrogen and oxygen). The calculations provide a natural explanation of the observed off-center features of these impurities in terms of dangling bonds, lone pairs and bond pairs - concepts which, in contrast to the usual molecular orbital and band theories, are well-defined within the context of the correlated wave functions used here.
The design of processing elements on a multiprocessor system with a high-bandwidth, high-latency interconnection network

A description is given of the ways in which the environment of a highly parallel, high-latency interconnection network is different from that encountered in a uniprocessor system. The impact of these differences on the design of the processing elements is discussed. Methods that can be used to evaluate the impact of architectural choices on the performance of any system that uses a similar network are examined. Two detailed designs of processing elements, one using a CISC (complex-instruction-set computer) processor and the other using a RISC (reduced-instruction-set computer) are given as examples. >
A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

Genes mutated in patients with Fanconi anemia (FA) interact with the DNA repair genes BRCA1 and BRCA2/FANCD1 to suppress tumorigenesis, but the molecular functions ascribed to them cannot fully explain all of their cellular roles. Here, we show a repair-independent requirement for FA genes, including FANCD2, and BRCA1 in protecting stalled replication forks from degradation. Fork protection is surprisingly rescued in FANCD2-deficient cells by elevated RAD51 levels or stabilized RAD51 filaments. Moreover, FANCD2-mediated fork protection is epistatic with RAD51 functions, revealing an unanticipated fork protection pathway that connects FA genes to RAD51 and the BRCA1/2 breast cancer suppressors. Collective results imply a unified molecular mechanism for repair-independent functions of FA, RAD51, and BRCA1/2 proteins in preventing genomic instability and suppressing tumorigenesis.
The value of real time ultrasonography in first trimester termination

The value of real time ultrasonography (RTUS) in the management of first trimester elective pregnancy terminations was studied in 120 consecutive patients. RTUS was found essential in determining accurate gestational ages, identifying incomplete pregnancy teminations, diagnosing abnormal pregnancies, and in performing difficult terminations. It is suggested that RTUS be employed in the routine management of first trimester pregnany terminations.
Isoflurane Attenuates blood-brain barrier disruption in Ipsilateral Hemisphere after subarachnoid hemorrhage in mice

Background and Purpose—We examined effects of isoflurane, volatile anesthetics, on blood–brain barrier disruption in the endovascular perforation model of subarachnoid hemorrhage (SAH) in mice. Methods—Animals were assigned to sham-operated, SAH+vehicle–air, SAH+1%, or 2% isoflurane groups. Neurobehavioral function, brain water content, Evans blue dye extravasation, and Western blotting for sphingosine kinases, occludin, claudin-5, junctional adhesion molecule, and vascular endothelial cadherin were evaluated at 24 hours post-SAH. Effects of sphingosine kinase (N,N-dimethylsphingosine) or sphingosine-1-phosphate receptor-1/3 (S1P1/3) inhibitors (VPC23019) on isoflurane's action were also examined. Results—SAH aggravated neurological scores, brain edema, and blood–brain barrier permeability, which were prevented by 2% but not 1% isoflurane posttreatment. Two percent isoflurane increased sphingosine kinase-1 expression and prevented a post-SAH decrease in expressions of the blood–brain barrier-related prote...
Combinatorial biosynthesis: Lesson learned from nature

Polyketides produced by bacteria and fungi represent an extremely rich source of biologically active compounds that find wide-ranging applications as antibiotics, immunosuppresants, antitumor agents, and antiparasitic agents. The striking structural diversity of polyketides that gives rise to these wide-ranging applications is dictated both by the polyketide synthase (PKS) responsible for assembling the carbon backbone of the molecule, and by the tailoring enzymes (such as glycosyl transferases and hydroxylases) that modify the polyketide ring. Seminal work in our understanding of the complex polyketides came a number of years ago with the revelation that erythromycin produced by Saccharopolyspora erythraea is assembled by a modular PKS (1, 2). The first module is responsible for priming erythromycin with propionyl CoA and catalyzing a decarboxylative condensation with methylmalonyl CoA. The remaining five modules catalyze successive condensations with methylmalonyl CoA before a terminal thioesterase (TE) domain releases the aglycone, deoxyerythronolide B. The presence or absence of ketoreductase (KR), dehydratase (DH), and enoyl reductase (ER) catalytic domains within the module controls the extent to which the β-carbonyl of the growing polyketide chain is processed. In this issue of the Proceedings researchers at the University of Minnesota have revealed that a similar modular PKS is responsible for ketolide biosynthesis in Streptomyces venezulae (Fig. 1) (3).
An Analysis of Segment Disclosures under SFAS No. 131 and SFAS No. 14

The purpose of this paper is to compare the segment reporting disclosures under SFAS No. 131 with those reported the previous year under SFAS No. 14. Under SFAS No. 131, firms are required to report segments consistent with the way in which management organizes the business internally. In addition, the accounting items disclosed for each segment are defined consistent with internal segment information used to assess segment performance. For many companies, this represents a significant change from the approach used to report segments under SFAS No. 14. Under SFAS No. 14, firms were required to disclose segment information by both line‐of‐business and geographic area with no specific link to the internal organization of the company or the measurements that were used for internal decision making. As a result, many complained that the resulting disclosures were highly aggregated and of limited use for decision‐making purposes. We find that the change in segment reporting requirements under SFAS No. 131 has m...
Unconditional Positive Regard, Empathetic Listening, and the Impact of Digital Text Driven Communication

Generally speaking, Generation N students are known to enjoy working in groups yet they often do not communicate effectively when measured by traditional expectations. This activity calls into question the impact that our daily nonvocal digital communicating has on our ability to empathetically listen.
Methotrexate cerebrospinal fluid pharmacokinetics in a patient with lymphoma treated with methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone

Abstract The role of "moderate-dose" systemic methotrexate in preventing central nervous system lymphomatous relapse is unknown. Certain patients with diffuse non-Hodgkin's histologic subtypes have an increased risk of relapse in the central nervous system, and it would be helpful to know if intravenous "moderate-dose" methotrexate might treat or possibly protect the meninges from involvement. In part, the rationale behind the recent regimen of methotrexate, bleomycin, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), and dexamethasone (m-BACOD) is to protect the central nervous system, and the empiric proof of this protection awaits the follow-up results of trials currently underway. In the meantime, the systemic and cerebrospinal fluid pharmacokinetics of moderate-dose intravenous methotrexate were studied in one patient whose histologic subtype places him at right risk for central nervous system involvement. Although the central nervous system levels of methotrexate in this patient never reached 1 × 10 −6 M , the levels exceeded 1 × 10 −7 M for at least 24 hours. The implications of peak dose versus sustained exposure to a lower dose of methotrexate are discussed.
RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 3: Basic life support

Objective To systematically examine the evidence on basic life support (BLS) in veterinary CPR and to determine knowledge gaps. Design Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical practice. Relevant questions were answered on a worksheet template and reviewed by the Reassessment Campaign on Veterinary Resuscitation (RECOVER) BLS domain members, by the RECOVER committee and opened for comments by veterinary professionals for 30 days. Setting Academia, referral practice, and general practice. Results Sixteen worksheets were prepared to evaluate techniques for chest compression and ventilation strategies as well as identification of cardiopulmonary arrest (CPA). Major recommendations arising from this evidence review include performing chest compressions at a rate of at least 100/min at a compression depth of one-third to half the width of the chest with minimal pauses, and early instigation of ventilation at a rate of 8–10 breaths/min in intubated patients, or using a 30:2 compression/ventilation ratio in nonintubated patients. Conclusions Although veterinary clinical trials are lacking, much of the experimental literature on BLS utilized canine models. The major conclusions from this analysis of the literature are the importance of early identification of CPA, and immediate initiation of BLS in these patients. Many knowledge gaps exist, most importantly in our understanding of the optimal hand placement and technique for chest compressions, warranting coordinated future studies targeted at questions of relevance to differences between veterinary species and humans.
Cost-effective screening for urinary tract infections in urogynaecological patients

This study aims to test the cost-effectiveness of reagent-strip urine nitrite compared with microbiological laboratory testing for screening of urinary tract infections (UTI). The study is a retrospective review of 708 female patients who underwent cystometry during a 1-year period. Urine dipstick nitrite was used as a screening test for UTI while urine cultures were taken as an outcome. Symptoms of UTI were noted. Of 708 patients screened, 70 (9.9%) had a significant UTI. Only 32 (4.5%)of 708 patients were nitrite positive. Urine dipstick nitrite has sensitivity of 40%, specificity of 99%, positive predictive value (PPV) of 88 % and negative predictive value (NPV) of 94%. If the screening test included symptoms for UTI together with urine nitrite, the results are: sensitivity 89%, specificity 31%, PPV 12% and NPV 96%. A combination of screening with urine nitrite and UTI symptoms can increase sensitivity to 89%. A total of 29% of specimens (screen negative=nitrite negative/asymptomatic) can then be excluded from UFEME/culture testing, thus resulting in cost savings.
The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1

A small group of core transcription factors, including Twist, Snail, Slug, and Sip1, control epithelial–mesenchymal transitions (EMTs) during both embryonic development and tumor metastasis. However, little is known about how these factors are coordinately regulated to mediate the requisite behavioral and fate changes. It was recently shown that a key mechanism for regulating Snail proteins is by modulating their stability. In this paper, we report that the stability of Twist is also regulated by the ubiquitin–proteasome system. We found that the same E3 ubiquitin ligase known to regulate Snail family proteins, Partner of paired (Ppa), also controlled Twist stability and did so in a manner dependent on the Twist WR-rich domain. Surprisingly, Ppa could also target the third core EMT regulatory factor Sip1 for proteasomal degradation. Together, these results indicate that despite the structural diversity of the core transcriptional regulatory factors implicated in EMT, a common mechanism has evolved for controlling their stability and therefore their function.
Oxidized Phospholipid-Induced Endothelial Cell/Monocyte Interaction Is Mediated by a cAMP-Dependent R-Ras/PI3-Kinase Pathway

Objective— Previous studies have demonstrated the importance of endothelial apical expression of connecting segment-1 (CS-1) fibronectin in mediating the entry of monocytes into atherosclerotic lesions and other sites of chronic inflammation. We previously demonstrated that oxidized PAPC (OxPAPC) increases monocyte-specific binding to arterial endothelium by causing deposition of CS-1 fibronectin on apical α 5 β 1 integrin. The present studies identify important signal transduction components regulating this pathway. Methods and Results— Using endothelial cells in culture, we demonstrate that activation of R-Ras is responsible for CS-1–mediated monocyte binding. Although few natural activators of R-Ras have been demonstrated, OxPAPC activated endothelial R-Ras by 2.5-fold but decreased levels of activated H-Ras. The importance of R-Ras/H-Ras balance in regulating monocyte binding was shown by overexpression studies. Constitutively active R-Ras enhanced monocyte adhesion, whereas coexpression with constitutively active H-Ras was inhibitory. Elevated cAMP, mediated by OxPAPC and specific components POVPC and PEIPC, was responsible for R-Ras activation, and dibutyryl cAMP and pertussis toxin were also effective activators of R-Ras. Using inhibitor and dominant-negative constructs, we demonstrated that phosphatidylinositol 3-kinase (PI3K) was a key downstream effector of R-Ras in this pathway. Conclusions— OxPAPC, POVPC, and PEIPC induce a cAMP/R-Ras/PI3K signaling pathway that contributes to monocyte/endothelial cell adhesion and potentially atherosclerosis.
Satellite ocean color observations of stormwater runoff plumes along the San Pedro Shelf (southern California) during 1997–2003

Knowledge of freshwater runoff plume dynamics in southern California is important for management of coastal water quality, because river discharge associated with episodic winter rainstorms can be a major source of pollutants and pathogens to coastal waters. The purpose of this study was to analyze the spatio-temporal dynamics of plumes at the San Pedro Shelf in southern California and identify factors influencingthe incidence and dispersal patterns of plumes. We used 1.1-km spatial resolution satellite images collected in 1997–2003 by the SeaWiFS optical radiometer. The area of each plume was detected by the backscatteringcharacteristics of surface waters in the vicinity of the mouths of four rivers that discharge to the San Pedro Basin. The rainstorm magnitude was estimated from atmospheric precipitation averaged over the total area of local watersheds. The plume size estimated from the backscattering coefficient nLw55541.3 mW cm � 2 mm � 1 sr � 1 was highly correlated with the amount of rainwater precipitated over the watershed area and accumulated duringthe period precedingthe plume. The relation between rainstorm and plume area was linear with zero intercept: that means that the minimum rainstorm magnitude under which no plume occurred in the study area was almost zero, and even small precipitation resulted in a plume. The persistence of the plumes was estimated by fittingthe coefficients of the model of plume water dissipation to achieve maximum correlation between the plume area and rainstorm: Twenty-five percent of rainwater dissipated daily, which gradually decreased the plume size. The size, alongshore and cross-shelf translocation of the plumes were modulated slightly by the local circulation, forced remotely by the equatorward wind a few hundred km to the south (alongthe coast of Baja California). The influence of tidal circulation on the plume area was slight and statistically insignificant. r 2005 Elsevier Ltd. All rights reserved.
CAP: Criticality analysis for power-efficient speculative multithreading

While speculative multithreading (SM) on a chip multiprocessor (CMP) has the ability to speed-up hard-to- parallelize applications, the power inefficiency of aggressive speculation is a concern. To improve SMs power effeciency, we note that not all the tasks that are running in a SM environment are equally critical. To leverage this insight, this paper develops a novel, widely-applicable task-criticality model for SM. It also proposes CAP, a novel architecture that builds a task-criticality graph dynamically and uses it to make scheduling decisions in a SM CMP. Experiments with SPECint, SPECfp, and Olden applications show that, in a CMP with one fast core and three slow ones, the E D2 with CAP is, on average, 91-95% of that without. Moreover, it is only 77-91% of the E D2 of a CMP with four fast cores and no CAP. Overall, we argue that scheduling for task criticality is beneficial.
Optical pumping of the polarized H - ion source at LAMPF

A report is presented on experiments to understand the laser optical pumping efficiency for the Optically Pumped Polarized Ion Source (OPPIS) at LAMPF. Measurements were made of ion beam polarization and current vs. laser power and potassium vapor thickness in order to understand the dependence of source performance on laser power and other parameters. Attempts to fit the data with simple scaling models to evaluate projected performance improvements are shown. The development of economical ways to make more efficient use of available laser power is described. >
Multiplex PCR Strategy for Rapid Identification of Structural Types and Variants of the mec Element in Methicillin-Resistant Staphylococcus aureus

Full characterization of methicillin-resistant Staphylococcus aureus (MRSA) requires definition of not only the bacterial genetic background but also the structure of the complex and heterologous mec element these bacteria carry, which is associated with drug resistance determinant mecA. We report the development, validation, and application of a multiplex PCR strategy that allows quick presumptive characterization of the mec element types based on the structural features that were shown to be typical of mec elements carried by several MRSA clones. The strategy was validated by using a representative collection of pandemic MRSA clones in which the full structure of the associated mec elements was previously determined by hybridization and PCR screenings and also by DNA sequencing. The method was tested together with multilocus sequence typing and other typing methods for the characterization of 18 isolates representative of the MRSA clones recovered during a hospital outbreak in Barcelona, Spain. The multiplex PCR was shown to be rapid, robust, and capable in a single assay of identifying five structural types of the mec element among these strains, three major and two minor variants, each one of which has been already been seen among MRSA characterized earlier. This technique should be a useful addition to the armamentarium of molecular typing tools for the characterization of MRSA clonal types and for the rapid tentative identification of structural variants of the mec element.
Incremental Frictional Abrasion Part III: Analysis of Abrasion Effects Using Photomicrographs of Fabric Cross Sections

Four blended polyester/cotton fabrics were subjected to incremental Accelerotor abrasion. These fabrics varied in blend level, fabric geometry, and finish. Photomicrographs of stained fabric cross ...
MENTAL WORK CRITERION DEVELOPMENT THROUGH SCALING: A TECHNIQUE FOR DETERMINING THE INTELLECTIVE STRUCTURE OF THE COLLEGE PROFESSOR'S JOB

Slimmary.-A classification of the intellective requirements of eight classroom performance factors of university-level psychology teachers is presented. Guilford's Structure-of-the-Inrellecr model was employed as an intellective referent. The magnitude estimation scales derived from faculty and students at German and American psychology deparunencs showed high agreement. About a decade ago Guilford (1959) published his three-dimensional matrix representing the operations, contents, and products of the intellect. Within the "operations" dimension, Guilford and his colleagues posited five categories: cognition, memory, divergent production, convergent production, and evaluation. The "contents" dimension included four categories: figural, symbolic, semantic, and behavioral. The six categories of units, classes, relations, systems, transformations, and implications made up the "products" dimension. The intersections of these three dimensions and their respective categories created 120 cells or 120 aspects of intelligent behavior. By the time of Guilford's 1959 publication some 50 cells had been shown to exist empirically. In a new book which summarized the work to date, Guilford (1967) brought the total number of known cells to 77. Recently (Guilford, 1966), the intellective contents category of "behavioral" was given empirical existence by the discovery of ability factors in it. Previously, this category had merely been hypothesized. It is hoped by Guilford and his colleagues that in future studies the existence of all 120 cells of the model will be demonstrated. One purpose of the study reported here was to relate the factors of the intellect posited by Guilford (1966) to the intellective complexity and magnitude of performing each of eight teaching performance job factors of psychology professors."~ was hoped that a definition of mental work could be developed through the application of Guilford's factors of the intellect. By knowing the 'The preparation of this report was facilitated by an Alexander von Humboldt fellowship award to the author, a visiting professor at the Psychological Institute of the Ruhr University in Germany/Heinz Heckhausen, Chairman, during the 1968-1969 academic year. Thanks are due La Salle College, Philadelphia, USA, for providing a sabbatical year free from teaching duties, and Applied Psychological Services Science Center for granting a leave of absence. 'Acknowledgment is made and appreciation expressed to Wolfgang Schoenpflug who provided constructive criticisms and to the following student assistants: John Gibbons, Wolfgang Lehmann, Larry Rosbach, and Ulrich Scheidt. Computer analyses were performed by James Dougherty, Stanley Goliasczewski, and Wolfgang Hawel. 'The word "professor" as used in this study means a professional teacher of psychology at the university level.
Landau theory of phase separation in cuprates.

I discuss the problem of phase separation in cuprates from the point of view of the Landau theory of Fermi liquids. I calculate the rate of growth of unstable regions for the hydrodymanics and collisionless limit and, in presence of long range Coulomb interactions, the size of these regions. These are analytic results valid for any strength of the Landau parameters.
VISUALISATION OF THROMBI WITH TECHNETIUM-99M UROKINASE A Negative Report

Direct imaging of thrombi with isotopically labelled agents would provide a convenient atraumatic method of diagnosing deep venous thrombosis. Urokinase labelled with technectium-99m has many theoretical advantages and successful use of this agent has been reported. A method for tagging urokinase with Tc-99m has been developed which preserves the clot-lysing ability of the urokinase. The thrombus imaging previously reported has not been duplicated.
Revisting the Transcendental: Design and Material in Architecture

Husserl’s Transcendental Phenomenology provides a fascinating attempt at challenging the scientific and conventional conceptions of what constitutes difference, and as a consequence of difference, categories. Embedded in the Western heritage of architecture are numerous intersubjective agreements on history and theory, yet a lateral comparison of built work and settings over time reveals a seemingly ever evolving, and on occasion revolutionary set of artifacts and ideas. The paper suggests that the media of architecture themselves set into motion a search and never-concluding set of iterations and provisional knowings further complexified and enabled by changing technologies and cultures. The paper reviews shortcomings of Alberti’s theory of proportions, Semper’s architectural materialist theory, and the most recent computer enabled biomorphic strategies. It is possible that at its heart transcendentalism in architecture is epistemological-phenomena gathered as a result of ontological investigative forces vs. Platonic forms. The paper concludes that there is a bridge between teacher and student through Heidegger’s (1971) “The Origin of a Work of Art”. Here the act of ideation, thinking, and making in dialectic with matter and creation of space, light, and, indeed, the creation of time itself are posed as originating from the intuitive and transcendental.
Advancing Space Mission Operations Best Practices between the Military and Civilian Communities

As spacecraft operations continue to adapt to the fiscal austerity of the post 9/11 federal budget environment, the national security and civilian space operations communities are increasingly tasked with merging their respective operations in order to achieve greater efficiency with limited resources. Where once these two environments existed in closed, narrowly defined operational settings, we now find that these two elements of space operations must work interdependently to achieve greater commonality across multiple programs. Both communities have developed distinctly different concepts of spacecraft operations, and normalizing these operations to allow cross-mission and intra-mission cooperation will be a key component in the continued success of Department of Defense (DOD) space missions. While there are necessarily distinct differences between the civilian and DOD space missions, commonalities exist as well. This paper will discuss the various ways in which the civilian and DOD space mission overlap in their capabilities, and where these capabilities can be effectively managed in order to increase operational efficiency and reduced operations cost. By doing so, the DOD and civilian space operations communities may be able to increase cooperation between programs, thereby enhancing mission capability while continuing to keep operations costs within budget.
Modulator Structure Using In(As, P)/lnP Strained Multiple Quantum Wells Grown By Gas-Source MBE

In(As, P)/InP strained multiple quantum wells (SMQW’s) were grown with gas-source molecular-beam epitaxy (GSMBE). A successful control of the As composition was achieved over a wide range by using two techniques. High-quality samples were characterized structurally and optically by x-ray diffractometry, transmission electron microscopy (TEM), photoluminescence (PL) and absorption measurements. Excitonic emission energy and the critical layer thickness of In(As, P)/InP SMQW's are calculated as a function of the As composition. The results show that 1.06, 1.3 and 1.55 µm excitonic emission can be achieved at room temperature using this material system. We also discuss the perspective of using In(As, P)/InP SMQW’s for modulator application.
Abstract 2726: Pepsin promotes growth and proliferation of laryngopharyngeal squamous cell carcinoma

Squamous cell carcinoma (SCC) of the head in neck is currently the 5 th most common cancer in the United States, with over 35,000 cases diagnosed in 2009. In addition to tobacco and alcohol, laryngopharyngeal reflux (LPR) is thought to be a significant risk factor for laryngopharyngeal SCC, but definitive associations between LPR and carcinogenesis are lacking. The purpose of this study was to investigate a role for refluxed pepsin in the promotion of SCC of the laryngopharynx. We recently discovered that inactive but stable pepsin (at pH7, in non-acidic reflux) is actively taken up by laryngeal epithelial cells by endocytosis in a receptor mediated manner and leads to intracellular damage and pro-inflammatory cytokine gene expression changes. This reveals a novel mechanism by which pepsin can cause cell/tissue damage and thereby promote carcinogenesis in patients with LPR. These studies were therefore done to specifically study the effect of neutral pH pepsin on laryngopharyngeal SCC proliferation. Pepsin levels were measured in posterior laryngeal biopsy specimens from patients with clinically diagnosed LPR (n = 5) and normal control subjects (n = 5) by Western blot analysis. Human hypopharyngeal SCC FaDu cells and normal human primary laryngeal epithelial cells were exposed to affinity purified human pepsin (0.1mg/ml, pH7) and gene expression levels measured on a Human Cancer PathwayFinder SuperArray by real-time RT-PCR. Cell proliferation was measured by growth curve, propidium iodide staining, and Click-iT Edu assay. Pepsin was detected in 3/5 patient laryngeal cancer biopsies, and was absent in all normal control laryngeal biopsies (0/5). Pepsin (0.1mg/ml, pH7) significantly altered the expression level of 27 genes implicated in carcinogenesis on SuperArray analysis with a pattern promoting generalized increased cellular proliferation. Flow cytometry analysis with propidium iodide staining demonstrated an increase in S phase distribution following exposure to pepsin in a time and dose dependent manner. Growth curve and Click-iT EdU proliferation assays also demonstrated increased proliferation following pepsin exposure. Pepsin increases cell proliferation and alters the expression of multiple genes implicated in carcinogenesis. Pepsin also appears to be selectively present in human laryngeal tumors and not in control specimens. Thus, uncontrolled chronic reflux of pepsin as in LPR may increase risk for laryngopharyngeal SCC development. Studies are ongoing to investigate the effect of pepsin on cell transformation, clone-forming ability, resistance to anoikis, DNA damage and reactive oxygen species levels. New therapies to prevent pepsin uptake and damage, such as pepsin inhibitors and receptor antagonists, are also being tested for patients with LPR. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2726. doi:10.1158/1538-7445.AM2011-2726
Composition of Membranes of Cells Transformed by Tumorigenic DNA and RNA Viruses

Continuous cell lines obtained from mouse and hamster embryonic tissue and human lung contain a homologous series of acidic glycolipids known as gangliosides. These complex lipids are highly concentrated in plasma cell membranes. The ganglioside pattern becomes greatly simplified when cells are transformed by tumorigenic DNA and RNA viruses. Non-transforming viruses and lytic infection of cells by tumorigenic viruses without neoplastic tranformation do not cause changes in gangliosides. The alterations of ganglioside composition are the result of specific blocks in the biosynthesis of these lipids. The significance of these impairments of membrane glycolipid formation and the nature of the regulatory site(s) involved are considered with regard to the altered social behavior of transformed cells.
Headache in Patients With Pituitary Lesions: A Longitudinal Cohort Study.

BACKGROUND Headache is a presenting feature in 37% to 70% of patients with pituitary tumor. Other pituitary lesions may also present with headache, and together these lesions account for about 20% of all primary brain lesions. Although pituitary lesions have been associated with headache, the exact nature of the relationship remains undefined. It is not always clear whether the presenting headache is an unrelated primary headache, a lesion-induced aggravation of a preexisting primary headache, or a separate secondary headache related to the lesion. OBJECTIVE To characterize headache in patients referred to a multidisciplinary neuroendocrine clinic with suspected pituitary lesions and to assess changes in headache in those who underwent surgery. METHODS We used a self-administered survey of headache characteristics completed by patients upon presentation and after any pituitary surgical procedure. RESULTS One hundred thirty-three participants completed the preoperative questionnaire (response rate of 99%). The overall prevalence of headache was 63%. Compared to patients without headache, the group with headache was more likely to be female (P = .001), younger (P = .001), and to have had a prior headache diagnosis (P < .001). Seventy-two percent of patients reported headache localized to the anterior region of the head. Fifty-one patients with headache underwent transsphenoidal pituitary surgery. Headache was not associated with increased odds of having surgery (odds ratio, 0.90). At 3 months, 81% of surgically treated patients with headache who completed the postoperative questionnaire (21/26) reported improvement or resolution of headaches. No patient who completed the postoperative questionnaire (44/84) reported new or worsened headache. CONCLUSION Frequent, disabling headaches are common in patients with pituitary lesions referred for neuroendocrine consultation, especially in younger females with a preexisting headache disorder. Surgery in this group was associated with headache improvement or resolution in the majority and was not found to cause or worsen headaches. Suggestions for revision of the International Classification of Headache Disorders diagnostic criteria pertaining to pituitary disorders are supported by these findings.
Ameliorating Ways of Dynamic Characteristic of Temperature Sensors

In order to improve the dynamic characteristic of temperature sensors and make the responding time of temperature sensors meet the requirement of quick response of temperature measure system,the method of adding PID control to temperature measure system is given in this paper,which are based on the analysis of the common use ameliorative ways and fuzzy control,then simulated with Simulink(MATLAB) tool. The result of simulation shows that the responding time of temperature sensor can be shortened greatly by using PID control and the dynamic characteristic of temperature sensor can be improved.
Evolution History of Gas Diffusion Velocity from Overpressured Source Rock of Qingshankou Group (K_1q_n)in Gulong Sag

The evolution history of gas diffusion velocity from overpressured sourcerock of Qing-shankou Group(K1qn) in Gulong sag has been studied based on the study of formation and evolution of the overpressure.The result shows that abnormal gas-bearing concentration of K1qn was formed in the early of K1n2 sedimentation period,then the gas began to diffuse upward and downward.Because abnormal gas-bearing concentration decreased to the smallest value,the gas diffusion was the weakest in the middle and late K1n4 sedimentation period and in the end of Quaternary sedimentation period.Therefore the gas diffusion of overpressured sourcerock of K1qn is divided into three evolution stages.The gas diffusion velocity increases gradually upward and downward in each stage,but the gas diffusion velocity downward is bigger than that upward.It is more favorable for gas in diffusion phase to accumulate in oil layer under K1qn than that above K1qn.This is the reason that gas accumulates much more in the oil layer under K1qn than that above K1qn.
Investigation report on a case of food poisoning caused by organophosphorus pesticide

Objective:To analyze field epidemiological investigation and laboratory test results on food poisoning caused by organophosphorus pesticide contamination,providing reference for handling food poisoning cases.Methods: Samples from the patients′ vomit,blood and leftover were collected and detection of four common physical and chemical poisoning indexes: organophosphorus,tetramine,carbamate esters and fluorine ethyl amide were detected according to the clinical symptoms.Results: organophosphorus pesticide were detected from the pickled food the patients took,the leftover and vomit of patients.Conclusion: This case of food poisoning was caused by organophosphorus pesticide.
Design and implementation of a terrain simulator and development tools

Realistic simulation environments are a popular area of study. Current military simulations, mapping software, and video games are all demanding more realistic physics and components. An understanding of the many components of such a simulator, and how they interact, is essential for an individual to successfully become part of a development team. To this end I planned, designed, implemented, and documented a simple terrain simulator, as well as auxiliary tools to assist in the creation of simulation data.
Comparison on throat swabs and respiratory tract aspirates for the detection of respiratory viruses from patients with pneumonia

社区获得性肺炎(CAP)是威胁人类健康的常见感染性疾病之一[1],本研究对肺炎病例咽拭子和下呼吸道标本中的呼吸道病毒分别进行多重实时荧光定量PCR检测,并比较两者差异.1.对象与方法:(1)病例标本收集:根据中华医学会CAP诊断标准,以北京市儿童医院作为监测哨点,收集96例CAP病例咽拭子和下呼吸道抽吸物标本后立即放入冷藏箱或4℃冰箱,送往实验室进行常见呼吸道病毒(鼻病毒、博卡病毒、冠状病毒、甲型H1N1及甲3型和乙型流感病毒、人偏肺病毒、腺病毒、呼吸道合胞病毒、副流感病毒1、3、4型)检测. 关键词：肺炎;咽拭子;下呼吸道抽吸物
The legitimacy of monarchs and the institutions of empires

Introduction Following the emergence of the Ottoman, Safavid, and Mughal dynasties, there was a subsequent ruler in each ruling lineage who transformed the nature of his state. In the fifteenth and sixteenth centuries these were the Ottoman Fatih Mehmet, that is Mehmet II, the Conqueror (1444–81); the Safavid Shah ‘Abbas I (1588–1629); and the Mughal Akbar (1556–1605). Each of them exhibited an adaptive personality and personal dynamism that enabled him to mold the state he inherited into a distinctly different and more formidable imperial entity. They did not play precisely analogous roles, since their dynasties had distinct histories and characteristics. In 1444 Mehmet II inherited a powerful and expansionist Anatolian and Balkan sultanate with established military, political, and religious institutions. Yet by his conquest of Constantinople and subsequent policies he substantially altered the Ottomans’ self-perceptions as well as the character of the Ottoman state. By the time of his death the Ottoman Sultanate had become a dominant, highly centralized slave empire whose ruler possessed hitherto unequalled autocratic power. In contrast, Shah ‘Abbas at age sixteen in 1588 inherited a fragile Safavid regime with a questionable future. During the sixteenth century Isma‘il's original religious charisma had atrophied in the face of his defeat at Chaldiran in 1514 and subsequent inertia, and his successors had proved incapable either of solving the intractable internecine conflicts and independent power of the Qizilbash or of decisively defeating their Ottoman and Uzbek enemies.
Types of oral contraceptives and breast cancer survival among women enrolled in Medicaid: A competing-risk model

Introduction Oral contraceptive pills have been implicated in the pathophysiology of breast cancer. Although many studies have examined the relationship between combined oral contraceptives (COCs) and breast cancer, there is a paucity of literature that discusses progestin-only oral contraceptives (POCs) and breast cancer. The purpose of this investigation is to examine potential associations between different types of oral contraceptives and breast cancer mortality in the South Carolina Medicaid population among different racial/ethnic groups.
Nondiffusive thermal transport and prediction of the breakdown of Fourier's law in nanograting experiments

An appropriate heat conduction model is indispensable for experimental data analysis in nanothermometry in order to extract parameters of interests and to achieve a fundamental understanding of phonon-mediated heat transfer in nanostructures and across interfaces. Recently, nanoscale periodic metallic gratings are used as a group of distributed heaters as well as transducers in nanothermometry. However, in this technique, there are coupled hotspot-size-dependent effective thermal conductivity (ETC) and hotspot-size-dependent thermal interface resistivity, which posts a challenge for experimental data analysis using Fourier’s law that fails to extract both ETC and thermal interface resistivity simultaneously. To overcome this challenge, a novel two-parameter nondiffusive heat conduction (TPHC) model, which has been successfully applied to data analysis in different types of pump-probe experiments, is applied to analyze laser-induced nondiffusive heat transfer in nanoscale metallic grating experiments. Sinc...
Contextualizing Satyagraha within the Feminist Movement in the US

The author argues that the mainstream US feminist historical documentation framework—the feminist waves—have organized feminist history to primarily record historical events that involve high statu...