cssi/SciSciGPT-SciSciNet huggingface dataset:
Isoproterenol stimulation of ornithine decarboxylase blocked by propranolol during ontogeny of the murine heart.

Fluctuations in the activity of fetal mouse heart ornithine decarboxylase (ODC) are positively correlated to growth rate. ODC activity was maximal (27 pmoles/min/mg of protein) at 13 days of embryogenesis, the earliest time that hearts could be dissected. Stimulation of fetal cardiac ODC activity was used as an index of cardiac responsiveness to adrenergic stimulation. The ability of either maternally injected or fetally injected isoproterenol to stimulate an increase in fetal heart ODC activity in embryos close to term was concentration-dependent. The beta -adrenergic stimulant, 10 mg/kg maternally or 2 mg/kg fetally, promoted a maximal response (300-400%). Maternal injections were used routinely, therefore, for ease of experimentation. The development of the fetal heart trophic response to beta -receptor agonists was examined after maternal injections of 2 or 10 mg/kg of isoproterenol from 13 to 21 days of gestation. Isoproterenol promoted an increase in myocardial ODC activity at all times monitored during fetal development. The highest drug-stimulated activity, 57 pmoles/min/mg of protein, occurred at 16-17 days of gestation. After this, the absolute specific enzyme activity achieved after isoproterenol declined, although the magnitude of the response remained at 2.5- to 3-fold above control until birth. The stimulation was blocked by propranolol (10 mg/kg s.c.). The maximal in vivo coupling of the beta -receptor to murine ODC activity, apparent from Day 13 of gestation, precedes the development of its in vitro coupling to the chronotropic response, first apparent after 17 days. ACKNOWLEDGMENTS We wish to acknowledge the technical assistance of Scott Ruth, Eleanor Fairbanks, Joanne Finch, and Mary Herber.
Similarities in long-term alloreactive T cell lines propagated from transfusion-enhanced and control-rejecting rat renal allografts.

On montre que les cellules T alloreactives peuvent etre propagees avec une egale frequence a partir d'allogreffes renales de rats stimulees par transfusion de sang de donneur et temoins en cours de rejet et que ces lignees presentent des caracteristiques phenotypiques et fonctionnelles comparables
Bridging the Archipelago between Row-Stores and Column-Stores for Hybrid Workloads

Data-intensive applications seek to obtain trill insights in real-time by analyzing a combination of historical data sets alongside recently collected data. This means that to support such hybrid workloads, database management systems (DBMSs) need to handle both fast ACID transactions and complex analytical queries on the same database. But the current trend is to use specialized systems that are optimized for only one of these workloads, and thus require an organization to maintain separate copies of the database. This adds additional cost to deploying a database application in terms of both storage and administration overhead. To overcome this barrier, we present a hybrid DBMS architecture that efficiently supports varied workloads on the same database. Our approach differs from previous methods in that we use a single execution engine that is oblivious to the storage layout of data without sacrificing the performance benefits of the specialized systems. This obviates the need to maintain separate copies of the database in multiple independent systems. We also present a technique to continuously evolve the database's physical storage layout by analyzing the queries' access patterns and choosing the optimal layout for different segments of data within the same table. To evaluate this work, we implemented our architecture in an in-memory DBMS. Our results show that our approach delivers up to 3x higher throughput compared to static storage layouts across different workloads. We also demonstrate that our continuous adaptation mechanism allows the DBMS to achieve a near-optimal layout for an arbitrary workload without requiring any manual tuning.
Can a workload coding system be used to assess and monitor a plastic surgery waiting list

Analysis of a waiting list based solely on the number of patients rather than the type and degree of difficulty can never give an accurate assessment of the work involved. It does not take account of the continued additions which occur from out patient clinic referrals. By applying an intermediate equivalent factor for loading to each case a better understanding and management of the waiting list can be obtained. There does not seem to be an exact relationship between the intermediate equivalent for any given case and the operating time.
Headache-Specific Locus of Control and Migraine-Related Quality of Life: Understanding the Role of Anxiety

This cross-sectional study examined the relationship between headache-specific locus of control (HSLC) and migraine-related quality of life, and anxiety as a mediator of this relationship. Two hundred and thirty-two people with migraine participated in the treatment of severe migraine trial. At baseline, participants completed self-report questionnaires of headache-specific locus of control (HSLC; subscales = internal, chance, and medical professionals), anxiety, and migraine-related quality of life. Correlations examined relationships between HSLC, anxiety, and migraine-related quality of life; ordinary least squares regression evaluated anxiety as a mediator of the relationship between HSLC and migraine-related quality of life. Higher internal HSLC was related to higher overall migraine-related quality of life (ps < .05) and emotion function impairments (p = .012). Anxiety mediated the relationship between internal HSLC and all measures of migraine-specific quality of life (ps < .05). Higher external (medical professionals and chance) HSLC was related to higher migraine-related quality of life impairments (all ps < .001). All HSLC beliefs are associated with higher migraine-related quality of life impairments. Anxiety mediates the relationship between internal HSLC and migraine-related quality of life.
The Age-Associated Reduction in Propulsive Power Generation in Walking.

Propulsive power generation during push-off in walking decreases with advancing age. A common explanation is an accommodation for sarcopenia and muscle weakness. Yet, muscle strengthening often yields disappointing outcomes for walking performance. We examine the hypothesis that declines in force or
Does the Empire Analogy Hold, or Are Critical Differences Emerging?

We have been describing the ways in which the Empire Analogy does hold for modem society. Yet, if modem society seems no longer to function according to the Polis Analogy, is it really becoming like the empires of old? There are dramatic differences between modem technocratic-bureaucratic society and the ancient empires. The analysis of these differences will surely be as cmcial for an understanding of the near future world as the similarities. There are, for instance, powerful and possibly permanent sources of delegitimation and dereification operating in modem society. And, the contemporary rationally oriented population is not at all like the traditionally bound populations of the ancient empires. Rational education, rational science, and rational law may be necessary in modem society, and they may have a more positive effect on the populace than the ‘ironcage theorists’ anticipated. The mass media, too, may produce multiple and divergent effects which could on the one hand help to create a manufactured charismatic aura around leadership strata which could reify power beyond our reach, while the media could, on the other hand, create the kind of cynicism and sceptical evaluation that delegitimates anything it touches.
Day-to-day Consistency in Positive Parent–Child Interactions and Youth Well-Being

The frequency of positive parent–child interactions is associated with youth adjustment. Yet, little is known about daily parent–child interactions and how day-to-day consistency in positive parent–child interactions may be linked to youth well-being. Using a daily diary approach, this study added to this literature to investigate whether and how day-to-day consistency in positive parent–child interactions was linked to youth depressive symptoms, risky behavior, and physical health. Participants were youth whose parents were employed in the IT division of a Fortune 500 company (N = 129, youth’s mean age = 13.39, 55 % female), who participated in an 8 day daily diary study. Analyses revealed that, controlling for cross-day mean levels of positive parent–child interactions, older (but not younger) adolescents who experienced more consistency in positive interactions with parents had fewer depressive and physical health symptoms (e.g., colds, flu). The discussion focuses on the utility of daily diary methods for assessing the correlates of consistency in parenting, possible processes underlying these associations, and intervention implications.
Carotid angioplasty and stenting. Will they match the gold standard

Technological advances in endoluminal equipment have changed treatment strategies for vascular disease. While the successful results of intervention in the subclavian and innominate arteries are well documented, our experience in the carotid arterial region is still in the early stages, and we are mindful of the potential for neurologic complications. We now find ourselves in the position of comparing the results of endovascular intervention with those of what has become a classic, "gold standard" procedure, carotid endarterectomy. Although we have yet to determine definitively the superiority of one method over another, it has become clear that some carotid lesions are considerably more amenable to endovascular treatment than others. We must evaluate the type and location of lesions, as well as the technical features of carotid angioplasty and stent placement, when we compare the results of endovascular and open procedures.
Spiritual Formation Within Christian Higher Education

ABSTRACTThe Christian university has a distinct responsibility to provide an environment devoted to the spiritual formation of students. Spiritual formation is not to be viewed as the only important goal of the university, thereby sacrificing intellectual or relational development, but rather spiritual formation is the aggregate “product” of the Christian college. It is a culminating attribute produced holistically from the collection of experiences gained while attending the Christian college. Christian higher education has distinct advantages in its history of spiritual formation while also facing significant challenges. Yet as the Christian colleges are true to their calling, there are few institutions better positioned to examine the spiritual formation of their students. This article reviews various aspects of this spiritual formation.
Immobilizing Tetraphenylethylene into Fused Metallacycles: Shape Effects on Fluorescence Emission

Herein, we describe the selective formation of a discrete fused metallarhomboid and a triangle by the careful control of the shape and stoichiometry of the building blocks. A tetraphenylethylene (TPE)-based tetrapyridyl donor is exploited as the bridging component, and coordination immobilization of the TPE unit within the rigid metallacyclic frameworks efficiently suppresses its intramolecular rotational motions. As a result, the fused polygons are innately emissive in dilute solution, representing an alternative to aggregation-induced emission. Upon further molecular aggregation, these metallacycles display aggregation-induced enhanced emissions. Interestingly, the fused rhomboid 7 shows a weaker fluorescence in dilute solutions relative to that of the fused triangle 8, while a reversal of emission intensities was observed in the aggregated state. These markedly different fluorescence efficiencies are likely due to the differences in the shapes of the fused polygons. Thus, this work shows that the prope...
The Effect of Time Delay on Emotion, Arousal, and Satisfaction in Human-Robot Interaction:

This study investigates the influence of time delay on user emotion, arousal, and satisfaction in human-robot interaction (HRI). Time delay is a gap between an input from a user and the correspondi...
Rhetoric for English Language Learners: Language Features of Five Latter-day Saint Devotional Talks

Every year selected leaders of the Church of Jesus Christ of Latter-day Saints (LDS) speak to large audiences for regular devotional meetings at Brigham Young University, a private religious college in Provo, Utah. This study investigates the possibility that a rhetorical analysis of devotional speakers could be an effective way to observe typical language features in English public speaking that would be especially helpful for advanced English-as-a-Second-Language (ESL) students in improving their comprehension and expression skills. Using published transcripts and cassette tape recordings of these Latter-day Saint discourses, the analysis includes lexical, figurative, syntactic, schematic, tonal, and semantic aspects of each devotional speech. The results suggest that such religious discourses contain language details and rhetorical patterns in English that ESL students could learn to recognize, understand, and use persuasively.
Distorted Capacity II: Neuropsychiatric Diseases and the Impaired Will

One reason psychiatric diseases are feared and stigmatized is that they impair the capacity for choice. Distortion of capacity is found in psychiatric diseases with disordered impulse and disordered impulse control, with some overlap. Most psychiatric diseases, for example addictions, phobias and obsessive compulsive disorder, involve disordered impulse. Several, for example schizophrenia and attention deficit hyperactivity disorder, also feature disordered control of impulse. These diseases constitute a challenge to the concept of free will based on neurogenetic individuality.
Changing Norms Following the 2016 U.S. Presidential Election: The Trump Effect on Prejudice

The 2016 presidential election was characterized by the remarkable expression of prejudice toward a range of groups. In two closely related studies (N = 388; 196 supporting Trump, 192 Clinton), we ...
A remote sensing-based model of tidal marsh aboveground carbon stocks for the conterminous United States

Abstract Remote sensing based maps of tidal marshes, both of their extents and carbon stocks, have the potential to play a key role in conducting greenhouse gas inventories and implementing climate mitigation policies. Our objective was to generate a single remote sensing model of tidal marsh aboveground biomass and carbon that represents nationally diverse tidal marshes within the conterminous United States (CONUS). We developed the first calibration-grade, national-scale dataset of aboveground tidal marsh biomass, species composition, and aboveground plant carbon content (%C) from six CONUS regions: Cape Cod, MA, Chesapeake Bay, MD, Everglades, FL, Mississippi Delta, LA, San Francisco Bay, CA, and Puget Sound, WA. Using the random forest machine learning algorithm, we tested whether imagery from multiple sensors, Sentinel-1 C-band synthetic aperture radar, Landsat, and the National Agriculture Imagery Program (NAIP), can improve model performance. The final model, driven by six Landsat vegetation indices and with the soil adjusted vegetation index as the most important (n = 409, RMSE = 310 g/m2, 10.3% normalized RMSE), successfully predicted biomass for a range of marsh plant functional types defined by height, leaf angle and growth form. Model results were improved by scaling field-measured biomass calibration data by NAIP-derived 30 m fraction green vegetation. With a mean plant carbon content of 44.1% (n = 1384, 95% C.I. = 43.99%–44.37%), we generated regional 30 m aboveground carbon density maps for estuarine and palustrine emergent tidal marshes as indicated by a modified NOAA Coastal Change Analysis Program map. We applied a multivariate delta method to calculate uncertainties in regional carbon densities and stocks that considered standard error in map area, mean biomass and mean %C. Louisiana palustrine emergent marshes had the highest C density (2.67 ± 0.004 Mg/ha) of all regions, while San Francisco Bay brackish/saline marshes had the highest C density of all estuarine emergent marshes (2.03 ± 0.004 Mg/ha). Estimated C stocks for predefined jurisdictional areas ranged from 1023 ± 39 Mg in the Nisqually National Wildlife Refuge in Washington to 507,761 ± 14,822 Mg in the Terrebonne and St. Mary Parishes in Louisiana. This modeling and data synthesis effort will allow for aboveground C stocks in tidal marshes to be included in the coastal wetland section of the U.S. National Greenhouse Gas Inventory. With the increased availability of free post-processed satellite data, we provide a tractable means of modeling tidal marsh aboveground biomass and carbon at the global extent as well.
Perishable Industries from Nan Ranch Ruin, New Mexico: A Unique Window into Mimbreño Fiber Technology:

Although the ceramic repertoire of the Mimbres has been extensively studied, illustrated, and published for over a century, Mimbreno perishables technology is poorly known. Detailed analysis of the small but highly informative plant-fiber artifact assemblage from NAN Ranch, New Mexico, permits the first characterization of Mimbres perishables production and use while affording the opportunity to establish the general outlines and salient events of the evolution of Mogollon perishables production. This developmental sequence is rooted in a local Archaic base of venerable antiquity but is strongly influenced by the introduction of “new” techniques and forms from northern Mexico at a time coextensive with the spread of agriculture into this portion of the greater American Southwest.
UCLA and the University of California

The University of California appears to have the most effective system of shared governance in the United States. Its foundation is a clear delegation to the faculty senate of the concerns logically and historically central to the idea of a community of scholars and students. This chapter describes its origins in the “Berkeley Revolution” of 1923 and its specific instantiation at UCLA. It then describes how the UCLA senate, working with the administration, met the challenges of the 1960s and 1970s in ways that produced lasting benefit. And it describes subsequent difficulties that some faculty describe as corporatization. This includes difficulties that have recently led the increasingly numerous and important contingent faculty to unionize.
The Denver Gem & Mineral Show: A Retrospective by Mark Ivan Jacobson. Lithographie, www.lithographie.org. 2017; 136 pages; $14 plus shipping and handling (softbound).

This well-conceived and attractive book is a year-by-year documentation of the highlights of the Denver Gem and Mineral Show by well-known mineral historian and pegmatite expert Mark Ivan Jacobson....
Influence of Deposition Parameters on Silicon Thin Films Deposited by Magnetron Sputtering

Amorphous and crystalline silicon films are widely used for microelectronic and photovoltaic devices. Here, silicon thin films were fabricated by magnetron sputtering and the deposition parameters were modified to enhance crystallinity of the films. The sputtering deposition was notably assisted by a low energy argon ion beam. The substrate temperature and sputtering power, as well as the energy of the ion beam, were used as deposition parameters. Finally, the optical and electrical properties of the deposited thin films were studied and demonstrate the possibility of using several deposition parameters to enhance the films crystallinity.
The Use of Multitrait–Multimethod Data for Detecting Nonlinear Relationships: The Case of Psychological Climate and Job Satisfaction

Previous monomethod research has found mixed support for nonlinear effects between certain job characteristics (e.g., job autonomy, job complexity) and outcome variables (e.g., job performance). We hypothesized that these weak nonlinear findings may be due to the prevalence of monomethod research that can lead to a lack of complete measurement and/or introduce common methods variance, either of which may mask the “true” shape of relationships. Using hierarchical regression analyses and a multitrait–multimethod (MTMM) research design, we found strikingly different results between monomethod and MTMM data when considering the relationships between three psychological climate variables and job satisfaction. While the monomethod results mirrored earlier inconclusive findings, the MTMM data indicated that nonlinear equations explained significantly more of the relationship between all three climate dimensions and job satisfaction. These results suggest that the use of MTMM data allows one to more effectively test for nonlinear effects. Furthermore, these nonlinear results suggest that the format of employee questionnaires should probably change from asking how much an employee has of certain constructs to asking does the employee want more or less of these constructs.
An Examination of Short-Term Borrowing in the United States

This paper uses data from the Survey of Consumer Finances to determine the characteristics of people who obtained high-interest loans to meet their short-term financing needs. Results indicate that individuals who were denied credit in the past were one and a half times more likely to borrow from alternative lenders (e.g., payday loan lenders and loan financing companies) than were individuals who had not previously been denied credit. Educational attainment, income, and wealth were negatively associated with borrowing from alternative institutions. The likelihood that, given the current economic downturn, more consumers may have to migrate from conventional credit markets such as banks or credit unions to alternative credit markets for their borrowing needs leads to a discussion of the necessity for more information and education to vulnerable populations.
Fast and Precise On-the-fly Patch Validation for All

Generate-and-validate (G&V) automated program repair (APR) techniques have been extensively studied during the past decade. Meanwhile, such techniques can be extremely time-consuming due to the manipulation of program code to fabricate a large number of patches and also the repeated test executions on patches to identify potential fixes. PraPR, a recentG furthermore, UniAPR addresses the imprecise patch validation issue by resetting the JVM global state via runtime bytecode transformation. We have implemented UniAPR as a publicly available fully automated Maven Plugin. Our study demonstrates for the first time that on-the-fly patch validation can often speed up state-of-the-art source-code-level APR by over an order of magnitude, enabling all existing APR techniques to explore a larger search space to fix more bugs in the near future. Furthermore, our study shows the first empirical evidence that vanilla on-the-fly patch validation can be imprecise/unsound, while UniAPR with JVM reset is able to mitigate such issues with negligible overhead.
Investigating The Role Of Dnc-2 And Dli-1 On Ampa Receptor Mediated Behaviors In C. Elegans

γ-amino-3-hydroxy-5methylisoxazole-4-proprionic acid (AMPA) receptors (AMPARs) are protein complexes involved in excitatory neurotransmission. AMPARs are tetrameric structures consisting of the pairings of GluA1, GluA2, GluA3, and GluA4 subunits. Dctn2 and Dync1li1 were found to interact with GluA2 in an immunoprecipitation screen that was performed on postnatal day 14 rat brains. DNC-2 and DLI-1 were identified as the C. elegans homologs of Dctn2 and Dync1li1, respectively, and are components of motor proteins that transport cargo throughout the cell. The goal of this project was to determine whether knocking down DNC-2 and DLI-1 by RNAi affects AMPA Receptor-mediated behaviors, including mechanosensation and chemosensation, in C. elegans.
Normalizing population receptive fields

The visual system is spatially organized. Each neuron responds to stimulation at a specific region in the visual field—its “receptive field”—and is largely unresponsive to stimulation elsewhere. For decades, electrophysiologists have characterized the receptive fields of neurons with invasive recordings (1, 2), providing the foundation for visual neuroscience. More recently, a technique was introduced that allows for noninvasive measurement of receptive field properties in humans using functional MRI (fMRI). This technique, known as population receptive field (pRF) mapping (3, 4), uses a model-based approach to measure the receptive fields of voxels, the small volumes of tissue from which responses are measured with fMRI. This is where the method gets its name: Because a voxel aggregates the activity of many neurons, the resulting receptive field is called a “population receptive field.” In the first instantiation of the pRF method (3), the receptive field of each voxel was modeled as a simple two-dimensional Gaussian that could vary in its size and position in the visual field. The size and position of a voxel’s receptive field are estimated by finding the values that best predict the voxel’s response to a variety of stimulus sequences (e.g., a bar sweeping through the visual field in different directions). This simple but powerful tool has been widely adopted in human neuroscience. Early studies validated the method, finding that measured pRFs largely square with established electrophysiological findings in animals. For instance, pRF size increases systematically across the visual hierarchy (3). Researchers have begun to leverage the pRF approach to characterize how receptive field properties are modulated … [↵][1]1To whom correspondence may be addressed. Email: samling{at}bu.edu. [1]: #xref-corresp-1-1
Cloud and Radiation Mission with Active and Passive Sensing from the Space Station

A cloud and aerosol radiative forcing and physical process study involving active laser and radar profiling with a combination of passive radiometric sounders and imagers would use the space station as an observation platform. The objectives are to observe the full three dimensional cloud and aerosol structure and the associated physical parameters leading to a complete measurement of radiation forcing processes. The instruments would include specialized radar and lidar for cloud and aerosol profiling, visible, infrared and microwave imaging radiometers with comprehensive channels for cloud and aerosol observation and specialized sounders. The low altitude, available power and servicing capability of the space station are significant advantages for the active sensors and multiple passive instruments.
Federal Reserve Control of the Money Stock: Comment

IT IS WIDELY BELIEVED that the money stock of the United States, somehow defined, should play a central role in the conduct of Federal Reserve monetary policy. In particular, it is believed that the Federal Reserve should publicly announce a target time path for the money stock and then try to make the actual stock follow that path closely. The analytical basis for this approach to Federal Reserve policy, however, is seriously deficient. Unfortunately, moreover, debate about this approach seldom focuses on the important, controversial issues about which views can justifiably differ. Instead, the debate often becomes mired in confusion and false issues. One important source of confusion is an inadequate analysis of the operating procedures through which the Federal Reserve implements its policy from one short-run period to the next. A second source is a widespread misperception of the economic processes determining the money stock. Most noneconomists, and even many economists, seem to believe that the Federal Reserve can straightforwardly cause the money stock to follow a target path closely month by month provided only that the Federal Reserve conscientiously tries to do so. A third source of confusion is a poor understanding of the two-stage decision process implicit in the
A Grounded Theory Approach to Identifying and Measuring Forensic Data Acquisition Tasks

As a relatively new field of study, little empirical research has been conducted pertaining to computer forensics.Â This lack of empirical research contributes to problems for practitioners and academics alike. For the community of practitioners, problems arise from the dilemma of applying scientific methods to legal matters based on anecdotal training methods, and the academic community is hampered by a lack of theory in this evolving field.Â A research study utilizing a multi-method approach to identify and measure tasks practitioners perform during forensic data acquisitions and lay a foundation for academic theory development was conducted in 2006 in conjunction with a doctoral dissertation. An overview of the studyâ€™s findings is presented within this article.
Implementing system simulation of C/sup 3/ systems using autonomous objects

The basis of all conflict recognition in simulation is a common frame of reference. Synchronous discrete-event simulation (DES) relies on the fixed points in time as the basic frame of reference. Asynchronous DES relies on fixed points in the model space as the basic frame of reference. It is pointed out that neither approach provides sufficient support for autonomous objects. The use of a spatial template as a frame of reference is proposed to address these insufficiencies. The concept of a spatial template is defined, and an implementation approach is offered. The use of this approach to analyze the integration of sensor data associated with command, control, and communication (C/sup 3/) systems is discussed. The spatial template basis of model coordination and the use of object-oriented software provide a mechanism for implementing autonomous objects in a DES modeling paradigm and computer software. The availability of such simulation tools has the potential to change the scope and level of use in systems analysis in general and in C/sup 3/ systems analysis in particular. >
Direct Linear Transformation Method for Three-Dimensional Cinematography

Abstract This study evaluated the “direct linear transformation” method developed by Abdel-Aziz and Karara (1971) for use with high-speed cine techniques. Two high-speed cameras were used to film a...
Outcomes of Global Education: External and Internal Change Associated With Study Abroad

This chapter provides an overview of external and internal changes associated with collegiate study abroad experiences. A brief review of the research literature is included along with recent research that sheds light on potential mechanisms associated with study abroad–related change. Recommendations for enhancing outcomes associated with study abroad are also provided.
Neuregulin3 alters cell fate in the epidermis and mammary gland

Background The Neuregulin family of ligands and their receptors, the Erbb tyrosine kinases, have important roles in epidermal and mammary gland development as well as during carcinogenesis. Previously, we demonstrated that Neuregulin3 (Nrg3) is a specification signal for mammary placode formation in mice. Nrg3 is a growth factor, which binds and activates Erbb4, a receptor tyrosine kinase that regulates cell proliferation and differentiation. To understand the role of Neuregulin3 in epidermal morphogenesis, we have developed a transgenic mouse model that expresses Nrg3 throughout the basal layer (progenitor/stem cell compartment) of mouse epidermis and the outer root sheath of developing hair follicles.
Isolation and characterization of a cutinase from Fusarium roseum culmorum and its immunological comparison with cutinases from F. solani pisi

Abstract Fusarium roseum culmorum, grown on apple cutin as the sole source of carbon, was shown to produce a cutin depolymerizing enzyme. From the extracellular fluid of these F. roseum cultures, a cutinase and a nonspecific esterase were isolated utilizing Sephadex G-100, QAE-Sephadex, and SP-Sephadex chromatography. The homogeneity of the cutinase was verified by polyacrylamide disc gel electrophoresis. The molecular weight of the cutinase was estimated to be 24,300 by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. Electrophoretic mobility of this enzyme was between that of Cutinases I and II from Fusarium solani pisi. The F. roseum cutinase hydrolyzed p-nitrophenyl butyrate and cutin, but not p-nitrophenyl palmitate, while the nonspecific esterase hydrolyzed the long-chain esters. Amino acid composition of F. roseum cutinase was found to be similar to that of F. solani pisi Cutinase I except for differences in the number of serine, valine, and cysteine residues. The time-course, protein concentration dependence, substrate concentration dependence, and pH optimum (10.0 for cutin hydrolysis) of the F. roseum cutinase was similar to the cutinases from F. solani pisi. The F. roseum cutinase was inhibited by diisopropylfluorophosphate and paraoxon, and the [3H]diisopropylphosphate group was covalently attached to the enzyme upon treatment with tritiated diisopropylfluorophosphate. Therefore, it is concluded that catalysis by cutinase involves an “active serine.” Immunochemical studies with a rabbit antibody prepared against F. solani pisi Cutinase I demonstrated that Cutinase II from this organism was immunologically very similar to, but not identical to, Cutinase I. On the other hand, the cutinase from F. roseum was immunologically quite different from the cutinases isolated from F. solani pisi in that it did not cross-react with anticutinase I. However, all three cutinases were virtually identical in their sensitivity to inhibition by anticutinase I, and all three enzymes were virtually completely inhibited by the anticutinase I.
Failure Time Models for Thinned Crime Commission Data

In studying the effects of correctional treatments and other variables on criminal behavior, researchers often use time to arrest, instead of time until a crime is committed, as the criterion variable. We examine conditions under which inferences can validly be made from the effects of predictors on the time to the first arrest to their effects on the time to the first crime committed. A nonhomogeneous Poisson process and a renewal process are considered as possible models for crime commission. An individual's crimes are assumed to result in arrest independently, with some fixed probability less than one. Multiplicative regression models for the time to the first crime are invariant with respect to thinning for either a Poisson or a renewal process. Proportional hazards models for the time to the first crime are invariant under thinning for a Poisson process but not for a general renewal process. Some limit results for thinned point processes yield an interpretation of proportional hazard effects as multi...
1981 Power Engineering Society Prize Paper Transient, Three-Dimensional, Finite-Element Analysis of Heat Flow in Turbine-Generator Rotors

The problem of three-dimensional, transient heat flow in the rotors of large turbine-generators is solved using a finite element formulation and employing new arch-shaped elements. Applications to negative sequence current heating and to rotor mechanical unbalance caused by thermal asymmetries are discussed. The method is shown to agree well with analytical calculations for heat flow in cylinders. Isothermal plots on a rotor isometric illustrate the pattern of heat flow.
The association of wavefront aberration and accommodative lag in myopes.

Abstract Accommodative lags, induced by a target at 33 cm (distance-induced condition) and by a −3.0 D lens (lens-induced condition), and wavefront aberrations were measured in 27 young myopic eyes. The accommodative lags and Strehl ratios derived from the wavefront aberrations in myopes were compared with those from 57 emmetropes. Accommodation was measured using a Canon R-1 autorefractor, while aberrations were measured using a psychophysical ray-tracing technique. In accord with previous results, larger accommodative lags were found for the myopes than the emmetropes in both the lens-induced and distance-induced conditions. The mean Strehl ratio was smaller in the myopes (0.079) than the emmetropes (0.091); this difference approached significance ( p = 0.055). In addition, for myopes the accommodative lag was significantly correlated with the Strehl ratio in the lens-induced condition ( r = −0.45, p r = −0.35, p = 0.07). No significant correlations were found for emmetropes. Possible reasons to account for these results are discussed.
Syndrome of Myelinated Retinal Nerve Fibers, Myopia, and Amblyopia : A Review

Myelinated retinal nerve fibers are developmental anomalies that are present in approximately 1% of all eyes. They may be associated with ipsilateral high myopia and amblyopia, and also may occur in association with various ocular and systemic abnormalities. Lesions may be congenital or acquired, static or dynamic, and can regress in the setting of several described conditions. The pathogenesis is thought to be due to the presence of ectopic oligodendrocyte-like cells in the retina as a result of a development or acquired insult. Visual acuity is typically poor to begin with, and the improvement of visual function in patients undergoing occlusion therapy has been, in general, limited. We discuss a series of 11 patients seen at the Cole Eye Institute with the condition of myelinated retinal nerve fibers, myopia, and amblyopia and describe the clinical characteristics. Three patients also had optic nerve dysplasia and a discussion of the literature related to this association was also performed.
Cerberus Barks in Vain: Poetic Asides in the Artusi–Monteverdi Controversy

The numerous documents associated with the controversy launched in 1600 by the Bolognese music theorist Giovanni Maria Artusi (1546–1613) against the madrigals of Claudio Monteverdi (1567–1643) have been well studied by scholars. But no one has yet engaged with the encomia included in the front and back matter of the printed books lying at the heart of the dispute: three sonnets (two by Vicenzo Maria Sandri and one by Mutio Manfredi) and a Latin carmen (by Erycius Puteanus) in the treatise L’Artusi, overo Delle imperfettioni della moderna musica (1600), and two madrigals by the poet and theologian Cherubino Ferrari in Monteverdi’s Il quinto libro de madrigali a cinque voci (1605). Although one might dismiss them as mere “occasional” poetry flattering Artusi, on the one hand, and Monteverdi, on the other, as well as their respective patrons, close reading suggests that these encomia represent attempts to claim the high ground not just on musical but also on philosophical and even religious terms. Ferrari’s praise of the composer finds a clear echo in Alessandro Striggio the Younger’s libretto for Monteverdi’s opera Orfeo (1607). All this provides an intriguing footnote, and perhaps something more, both to the controversy over the seconda pratica madrigal and to Orfeo in their broader Ferrarese and Mantuan contexts.
Turbo cyclone for oil spill remediation

A novel turbo-cyclone separator with integrated capacitive sensor array is proposed for highly efficient oil spill cleanup and oil recovery applications. The sensor array features linearly decoupled elements that enable resolving of process parameters in real-time.
Weak independence and veto power

Abstract Weak independence (WI) prevents x from socially ranking above y at profile p if y ranks above x at profile p′ and each individual ordering of {x,y} is the same at p as at p′. If f is transitive-valued and satisfies WI and Pareto then someone has veto power.
Driving course prediction for vehicle handling maneuvers

This paper aims at predicting the future driving course, which we define as a combination of two bifurcating channels — future speed and steering action that in turn derive a future driving trajectory during a curve. In defining the relation of these two channels, human factors, such as the stressfulness, comfort level, and skillfulness of the driver, are paid particular attention to. While the modeling and forecast of speed and steering angle are to some extent separated, a hidden Markov model (HMM) that's designed to mimic driver's intention integrates them by making subjective corrections. The proposed algorithm has been proved effective on realistic driving data based on a prototype vehicle at Ford.
Stimulated Generation of Superluminal Light Pulses via Four-Wave Mixing

We report on the four-wave mixing of superluminal pulses, in which both the injected and generated pulses involved in the process propagate with negative group velocities. Generated pulses with negative group velocities of up to ${v}_{g}=\ensuremath{-}\frac{1}{880}c$ are demonstrated, corresponding to the generated pulse's peak exiting the 1.7 cm long medium $\ensuremath{\approx}50\text{ }\text{ }\mathrm{ns}$ earlier than if it had propagated at the speed of light in vacuum, $c$. We also show that in some cases the seeded pulse may propagate with a group velocity larger than $c$, and that the generated conjugate pulse peak may exit the medium even earlier than the amplified seed pulse peak. We can control the group velocities of the two pulses by changing the seed detuning and the input seed power.
Resuscitation by countershock

The possibility of recovery of the fibrillating heart has been the subject of extensive experimental work, the results of which demonstrate conclusively that normal rhythmic functioning can be restored successfully in many cases.
The level structure of 51V, 53Mn and 55Co by (3He, d) reactions☆

Abstract The 50Ti(3He, d)51V, 52Cr(3He, d)53Mn and 54Fe(3He, d)55Co reactions were investigated using incident 3He ions of 10, 11 and 12 MeV, and ground-state Q-values of 2.555±0.015, 1.070±0.015 and −0.428±0.015 MeV were measured for these reactions, respectively. Deuteron spectra were obtained at 23 scattering angles between 7.5° and 172.5°. A distorted-wave analysis of these data was carried out to obtain lp values and spectroscopic strengths. The results are compared with other experimental results and with shell-model predictions. The low-lying, even-parity states are discussed in terms of target core excitations.
Step load moving with superseismic velocity on the surface of an elastic-plastic half-space

Abstract The plane strain problem of a step load moving with uniform superseismic velocity V > c p on the surface of a half-space is considered for an elastic-plastic material obeying the von Mises yield condition. Using dimensional analysis the governing quasi-linear partial differential equations are converted into ordinary nonlinear differential equations which are solved numerically using a digital computer. To overcome computing difficulties asymptotic solutions are derived in the vicinity of a singular point of the differential equations. Typical numerical results are presented for selected values of significant non-dimensional parameters, i.e. of the surface load p o / k , of Poisson's ratio v, and of the velocity ratio V / c p .
Invertebrate Communities Associated with Bangia Atropurpurea and Cladophora Glomerata in Western Lake Erie

The appearance of the marine alga Bangia atropurpurea (Rhodophyta) in Lake Erie has been followed by its rapid dispersal throughout the eulittoral zone of the lake. Bangia was extensively sampled to determine its suitability as a habitat for littoral organisms. Present data indicate that the only organisms capable of maintaining populations on Bangia filaments are larval Chironomidae. Cladophora supports a larger and more diverse community. It is concluded that the mucilaginous cell wall of Bangia provides a less stable substrate for attached or clinging organisms than does the cellulose cell wall of Cladophora. The presence of Bangia in the littoral zone of Lake Erie results in a reduction of the quantity and diversity of algal epiphytes and may negatively impact the littoral food web.
Central orexin-A changes the gastrointestinal motor pattern from interdigestive to postprandial in rats

Orexin-A, also described as hypocretin-I, was discovered in the extracts of the rat brain. OXA is implicated in a wide variety of physiological functions, such as feeding, arousal, behavioral activity, energy homeostasis and gastrointestinal motility. Orexin receptor type-1 is highly expressed in the dorsal motor nucleus of vagus. Although peripherally administered OXA abolishes small intestinal interdigestive contractions in rats, it still remains unclear whether central OXA affects interdigestive GI motility in rats. Two strain gauge transducers were attached on the antrum and duodenum to record circular muscle contractions. Spontaneous gastroduodenal contractions were recorded in freely moving conscious rats. OXA (1-20 µg) was administered intracerebroventricularly (i.c.v.). Atropine pretreatment (1 mg/kg, i.p.) and truncal vagotomy were performed to elucidate the neural pathways of central OXA. OXA (1-20 µg) dose-dependently disrupted the interdigestive phase III-like contractions and induced an irregular postprandial-like motility pattern in the stomach and duodenum. The stimulatory effect of OXA on gastroduodenal postprandial-like motility pattern was abolished by atropine and truncal vagotomy. Central administration (i.c.v.) of selective OXA receptor antagonist, SB-334867 (16 µg), enhanced gastric spontaneous phase III-like contractions. It is suggested that central OXA changes GI motor pattern from interdigestive to postprandial via the vagal cholinergic pathways. Endogenous OXA may have an inhibitory role in interdigestive GI motility in rats.
Methods for Studying Innovation Development in the Minnesota Innovation Research Program

This paper describes the methods being used by the Minnesota Innovation Research Program to develop and test a process theory of innovation which explains how and why innovations develop over time and what developmental paths may lead to success and failure for different kinds of innovations. After a background description of the longitudinal field research, this paper focuses on the methods being used to examine processes of innovation development. These methods pertain to the selection of cases and concepts, observing change, coding and analyzing event data to identify process patterns, and developing theories to explain observed innovation processes. We believe these methods are applicable to other studies that examine a range of temporal processes, including organizational startup, growth, decline, and adaptation.
Erratum to: The Role of Interferon Therapy in Patients With Hepatocellular Carcinoma

Interferon (IFN) not only may have antiviral properties against hepatitis C, but also may reduce the risk of hepatocellular carcinoma (HCC) through anticarcinogenic properties or indirectly by antifibrotic effects. Because patients with chronic hepatitis C and cirrhosis are at risk for HCC, IFN was used to prevent or treat HCC in patients with hepatitis C. Studies demonstrate that the risk of HCC in hepatitis C patients who are sustained viral responders is substantially reduced but not eliminated. The Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis trial demonstrated that maintenance therapy with IFN does not reduce the risk of HCC in patients with bridging fibrosis or cirrhosis. Other studies suggest the risk of HCC is reduced with IFN maintenance therapy in older patients or in patients whose α-fetoprotein levels decline. A randomized clinical trial demonstrated IFN therapy is not effective against HCC. Few studies suggest IFN may reduce the risk of recurrent HCC or reduce tumor burden after ablation or resection. Larger trials are needed to determine if IFN can prevent tumor recurrence after resection or locoregional therapy in patients with hepatitis C cirrhosis and HCC.
Prediction of the microyield strength of polymer matrix composites

A theory for the prediction of the creep and the microyield strength of composite laminates with viscoelastic matrices has been developed and tested. Precise creep curves from three laminates with arbitrary orientations provide the necessary input data. The time-dependent lamina properties are derived for subsequent use with standard laminate codes. Both the level and the shape of creep and strain recovery curves can be predicted. Extensions of the theory to include the effects of microcracking are outlined.