cssi/SciSciGPT-SciSciNet huggingface dataset:
A preliminary analysis of outcomes and end range procedures used to achieve centralization in people with low back pain.

AbstractObjectives: To investigate the relationship between clinical outcome and the types of end range procedures used to achieve centralization in a sample of patients with low back pain (LBP) and/or peripheral symptoms.Methods: Small sample retrospective analysis of an observational cohort. Patients with LBP who centralized during initial visit at two physical therapy clinics were recruited to participate. The types of end range procedures used to achieve centralization were documented during each office visit and a chart review was performed after 4 weeks. Outcomes were determined by improvement in the Oswestry Disability Index (ODI) score after 4 weeks. Statistical analysis determined the association between the types of end range procedures and outcomes.Results: Thirty-one patients gave consent to participate. Nineteen patients met inclusion criteria and were included in data analysis. After 4 weeks, the improvement in mean ODI scores was 15.89 ± 16.28. Differing end range procedures were used to ac...
The Role of Repulsion in Colloidal Crystal Engineering with DNA

Hybridization interactions between DNA-functionalized nanoparticles (DNA-NPs) can be used to program the crystallization behavior of superlattices, yielding access to complex three-dimensional structures with more than 30 different lattice symmetries. The first superlattice structures using DNA-NPs as building blocks were identified almost a decade ago, yet the role of repulsive interactions in guiding structure formation is still largely unexplored. Here, a comprehensive approach is taken to study the role of repulsion in the assembly behavior of DNA-NPs, enabling the calculation of interparticle interaction potentials based on experimental results. In this work, we used two different means to assemble DNA-NPs—Watson–Crick base-pairing interactions and depletion interactions—and systematically varied the salt concentration to study the effective interactions in DNA-NP superlattices. A comparison between the two systems allows us to decouple the repulsive forces from the attractive hybridization interacti...
Biorational and Conventional Plant Protectants Reduce Feeding by Adult Japanese Beetles

Abstract Nine commercial plant protectants were tested for efficacy against feeding by adult Japanese beetles (Popillia japonica Newman). Treatments included an endotoxin from a bacterium [Bacillus thuringiensis (Berl.) var. san diego]; microencapsulated pyrethrum extracted from pyrethrum [Tanacetum cinnerariifolium (Trev.) Schultz-Bip.], two extracts from neem (Azadirachta indica A. Juss); an extract from cayenne pepper (Capsicum annuum L. var. annuum Longum Group); an extract from garlic (Allium sativum L.); rotenone extracted from galedupa (Derris trifoliata Lour.) and barbasco [Lonchocarpus sericeus (Poiret) Kunth] or timbo (L. nicou Aublet D.C.); carbaryl (1-napthyl methylcarbamate); and the pyrethroid, fenpropathrin. Experimental plots were located at the Horticulture Field Laboratory (HFL), Raleigh, and the Mountain Horticultural Crops Research and Extension Center (MHCREC), Fletcher, NC. Himalayan birches [Betula utilis var. jacquemontii (Spach) Winkl.] were used as host plants. Treatments were ap...
Land to sea transitions in vertebrates: the dynamics of colonization

Vertebrates with terrestrial or freshwater ancestors colonized the sea from the Early Triassic onward and became competitively dominant members of many marine ecosystems throughout the Mesozoic and Cenozoic eras. The circumstances that led to initial marine colonization have, however, received little attention. One hypothesis is that mass extinction associated with ecosystem collapse provided opportunities for clades of amphibians, reptiles, birds, and mammals to enter marine environments. Another is that competitive pressures in donor ecosystems on land and in freshwater, coupled with abundant food in nearshore marine habitats, favored marine colonization. Here we test these hypotheses by compiling all known secondarily marine amniote clades and their times of colonization. Marine amniotes are defined as animals whose diet consists primarily of marine organisms and whose locomotion includes swimming, diving, or wading in salt water. We compared the number of clades entering during recovery phases from mass extinctions with the rate of entry of clades during nonrecovery intervals of the Mesozoic and Cenozoic. We conservatively identify 69 marine colonizations by amniotes. The only recovery interval for which prior mass extinction could have been a trigger for marine entry is the Early Triassic, when four clades colonized the sea over 7 Myr, significantly above the rates at which clades entered during other intervals. High nearshore productivity was a greater enticement to colonization than was a low diversity of potential marine competitors or predators in nearshore environments of a highly competitive terrestrial or freshwater donor biota. Rates of marine entry increased during the Cenozoic, in part because of rising productivity and in part thanks to the participation of warm-blooded birds and mammals, which broadened the range of thermal environments in which initial colonization of the sea became possible.
Membrane trafficking in morphogenesis and planar polarity

Our understanding of how membrane trafficking pathways function to direct morphogenetic movements and the planar polarization of developing tissues is a new and emerging field. While a central focus of developmental biology has been on how protein asymmetries and cytoskeletal force generation direct cell shaping, the role of membrane trafficking in these processes has been less clear. Here, we review recent advances in Drosophila and vertebrate systems in our understanding of how trafficking events are coordinated with planar cytoskeletal function to drive lasting changes in cell and tissue topologies. We additionally explore the function of trafficking pathways in guiding the complex interactions that initiate and maintain core PCP (planar cell polarity) asymmetries and drive the generation of systematically oriented cellular projections during development.
Treatment of extensive vulvar condylomata acuminata with topical 5-fluorouracil.

Forty-nine nonpregnant women with extensive condylomata acuminata of the vulva were studied to evaluate the effectiveness of topical 5-fluorouracil (5-FU) for treating vulvar condylomata and to compare the results of continuous use with periodic use of the medication. Patients using the continuous regimen were instructed to apply 5% 5-FU cream to the vulva each night for 6 weeks or until a brisk inflammatory reaction occurred. The periodic regimen consisted of applying 5-FU cream on 2 consecutive nights per week for 10 week. Thirty-five patients (71%) responded to 5-FU treatment (20 complete responses, 41%; 15 partial responses, 30%). Fourteen patients (29%) did not respond. The response rates observed in 19 patients using the continuous regimen (eight complete responses, five partial responses, and six treatment failures) were not significantly different from the response rates obtained in 30 patients with the periodic regimen (12 complete responses, 10 partial responses, and eight treatment failures; P greater than .05, chi-squared test). The periodic regimen caused fewer side effects than the continuous regimen. I conclude that topical 5-FU is effective for treatment of vulvar condylomata acuminata and that periodic applications are preferable to continuous applications.
r- and K-Selection and Microbial Ecology

The essence of the concept of r- and K-selection is that organisms strive to maximize their fitness for survival in either uncrowded (r-selection) or crowded (K-selection) environments. Fitness is defined following ecological convention as the proportion of genes left in the population gene pool (Pianka, 1983, p. 10). The terms r and K refer, respectively, to the maximum specific rate of increase (maximum specific growth rate minus minimum specific death rate) of an organism and to the density of individuals that a given environment can support at the population equilibrium. Since both r and K can vary within a species and are subject to modification, the division of natural selection into r- and K-selection is of considerable basic interest in evolutionary ecology.
Cooperative data and computation partitioning for decentralized architectures

Scalability of future wide-issue processor designs is severely hampered by the use of centralized resources such as register files, memories and interconnect networks. While the use of centralized resources eases both hardware design and compiler code generation efforts, they can become performance bottlenecks as access latencies increase with larger designs. The natural solution to this problem is to adapt the architecture to use smaller, decentralized resources. Decentralized architectures use smaller, faster components and exploit distributed instruction-level parallelism across the resources. A multicluster architecture is an example of such a decentralized processor, where subsets of smaller register files, functional units, and memories are grouped together in a tightly coupled unit, forming a cluster. These clusters can then be replicated and connected together to form a scalable, high-performance architecture. The main difficulty with decentralized architectures resides in compiler code generation. In a centralized Very Long Instruction Word (VLIW) processor, the compiler must statically schedule each operation to both a functional unit and a time slot for execution. In contrast, for a decentralized multicluster VLIW, the compiler must consider the additional effects of cluster assignment, recognizing that communication between clusters will result in a delay penalty. In addition, if the multicluster processor also has partitioned data memories, the compiler has the additional task of assigning data objects to their respective memories. Each decision, of cluster, functional unit, memory, and time slot, are highly interrelated and can have dramatic effects on the best choice for every other decision. This dissertation addresses the issues of extracting and exploiting inherent parallelism across decentralized resources through compiler analysis and code generation techniques. First, a static analysis technique to partition data objects is presented, which maps data objects to decentralized scratchpad memories. Second, an alternative profile-guided technique for memory partitioning is presented which can effectively map data access operations onto distributed caches. Finally, a detailed, resource-aware partitioning algorithm is presented which can effectively split computation operations of an application across a set of processing elements. These partitioners work in tandem to create a high-performance partition assignment of both memory and computation operations for decentralized multicluster or multicore processors.
The Liouville Equation and Prediction of Forecast Skill

The Liouville equation represents the consistent and comprehensive framework for dealing with uncertainty arising in meteorological forecasts due to uncertainty in the initial condition. This equation expresses the conservation of the phase space integral of the number density of realizations of a dynamical system originating at the same time instant from different initial conditions, in a way completely analogous to the continuity equation for mass in fluid mechanics. Its solution describes the temporal evolution of the probability density function of the state vector of a given dynamical model.
Rapid desorption of radium isotopes from black shale during hydraulic fracturing. 1. Source phases that control the release of Ra from Marcellus Shale

Abstract Hydraulic fracturing of the Marcellus Shale produces wastewaters that are hypersaline and highly enriched in isotopes of radium. Radium is understood to derive from the Marcellus Shale itself, but its source phases and their contributions to wastewater production have not been described. Using sequential extractions and experimental leachates, we characterize two distinct end-members that could contribute Ra to wastewaters, (1) a mineral phase, which hosts labile 228 Ra and has 226 Ra/ 228 Ra atom ratios ~250, and (2) an organic phase, which hosts exchangeable 226 Ra and has 226 Ra/ 228 Ra ~10,000. In leaching experiments we observed rapid extraction of Ra from these phases, with high ionic strength solutions leaching up to 14% of Ra from the shale in just hours. Radium concentrations and 226 Ra/ 228 Ra ratios increase with [Ca 2+ ] of the leaching solution, and solutions approaching 1 M Ca 2+ produce 226 Ra/ 228 Ra ratios compatible with Marcellus wastewaters. In contrast, pure water removes 226 Ra/ 228 Ra ratios incompatible with wastewaters. Experimental results and wastewater data together provide a coherent picture, that the distinctive Ra isotopic signature of Marcellus wastewaters results from contemporaneous water-rock interactions that promote desorption of 226 Ra from organics during hydraulic fracturing.
How to benefit from weekend physical activities: Moderating roles of psychological recovery experiences and sleep

This study examines the short-term recovery benefits of weekend physical activity on reduced negative affective state (NA) on Monday morning, using a weekly diary method from 70 employees across four weekends (repeated pre- and post-weekend measures). The first hypothesis tests the within-person relationship between weekend physical activity and post-weekend NA. The results of multilevel path analysis show that the main effect of weekend physical activity on reduced Monday NA is not significant. In addition, the study tests weekend recovery experiences (i.e., psychological detachment, relaxation, mastery, and control) and sleep hours as possible moderators. The findings support the moderating effects of psychological detachment and sleep hours. Specifically, weekend physical activity is related to lower Monday NA only if workers achieve high psychological detachment from work during the weekend. If not, their weekend physical activity is associated with higher NA. Also, the benefit of weekend physical activity occurs only when workers sleep longer on the weekend nights. The findings suggest that physical activity has important boundary conditions-psychological detachment and sleep duration-that influence its recovery effects on NA. The complex relationship between exercise and recovery is discussed, along with the implications of the findings for future research.
The VIA inventory of strengths, positive youth development, and moral education

The VIA Inventory of Strengths and the VIA model were originally developed to assess and study 24 character strengths. In this paper, I discuss how the VIA Inventory and its character strength mode...
Nickel: a framework for design and verification of information flow control systems

Nickel is a framework that helps developers design and verify information flow control systems by systematically eliminating covert channels inherent in the interface, which can be exploited to circumvent the enforcement of information flow policies. Nickel provides a formulation of noninterference amenable to automated verification, allowing developers to specify an intended policy of permitted information flows. It invokes the Z3 SMT solver to verify that both an interface specification and an implementation satisfy noninterference with respect to the policy; if verification fails, it generates counterexamples to illustrate covert channels that cause the violation.Using Nickel, we have designed, implemented, and verified NiStar, the first OS kernel for decentralized information flow control that provides (1) a precise specification for its interface, (2) a formal proof that the interface specification is free of covert channels, and (3) a formal proof that the implementation preserves noninterference. We have also applied Nickel to verify isolation in a small OS kernel, NiKOS, and reproduce known covert channels in the ARINC 653 avionics standard. Our experience shows that Nickel is effective in identifying and ruling out covert channels, and that it can verify noninterference for systems with a low proof burden.
AB0077 Ciprofloxacin-related acute peripheral neuropathy in a patient with sle

Background Ciprofloxacin is a broad-spectrum antibiotic commonly used for skin, respiratory tract and urinary tract infections. It is associated with a very few serious adverse effects.1,2 In a report of worldwide experience with ciprofloxacin, peripheral neuropathy was reported in one patient only, with no details available.3 We describe the first case of ciprofloxacin-related peripheral neuropathy in a patient with SLE. Objectives Methods Results The patient, 18-yr-old African-American female, presented with five-day history of an acute onset of progressive tingling, numbness and weakness of both lower extremities. The symptoms began one day after the initiation of ciprofloxacin for treatment of urinary tract infection. At the time of hospital admission, patient was found to have bilateral symmetrical decrease in pain, temperature and light touch perception below knees, with weakness of both plantar- and dorsi-flexion of the ankle and an absence of bilateral ankle reflexes. Nerve conduction studies and EMG were done, which revealed a predominant sensory axonal neuropathy in lower extremities, with relative sparing of the motor component. MRI of the spine didn’t reveal any evidence of transverse myelitis. A diagnosis of ciprofloxacin-related peripheral neuropathy was made. Ciprofloxacin was discontinued. During the two day stay in the hospital, she started regaining the sensation in both lower extremities, without any other intervention. Within 10 days of the discontinuation of ciprofloxacin, her symptoms had completely resolved. She had no recurrence of the symptoms and no residual neurological deficit. Conclusion Peripheral neuropathy is an uncommon manifestation of SLE. It is more rarely seen as adverse effect of ciprofloxacin. It is possible that the presence of SLE, and the concomitant use of hydroxychloroquine in our patient may have predisposed her to the occurrence of this rare adverse effect of ciprofloxacin. A similar case of possible drug interaction has been reported in a patient receiving therapy with ciprofloxacin, NSAID?s and chloroquine, who experienced neurological adverse effect.4 References Rahm V, Schacht P. Safety of ciprofloxacin. A review. Scand J Infect Dis Suppl. 1989;60:120–8 Schacht P, Arceri G, Hullmann R. Safety of oral ciprofloxacin. An update based on clinical trial results. Am J Med. 1989;87(5A):98S–102S Reiter C, Pfeiffer M, Hullman RN. Safety of ciprofloxacin based on Phase IV studies in the Federal Republic of Germany. Am J Med. 1989;87(5A):103S–108S Rollof J, Vinge E. Neurologic adverse effects during concomitant therapy with ciprofloxacin, NSAID?s and chloroquine: possible drug interaction. Ann Pharmacother. 1993;27(9):1058–9
Stage migration and survival in DLBCL patients before and after the approval of positron emission tomography (PET) scan: Population-based analysis using the U.S. National Cancer Data Base (NCDB).

8561 Background: PET scan was approved by the US Medicare for diagnosis and staging of NHL in July 2001. We studied the DLBCL stage distribution and overall survival (OS) before and after introduct...
Cell force-mediated matrix reorganization underlies multicellular network assembly

Vasculogenesis is the de novo formation of a vascular network from individual endothelial progenitor cells occurring during embryonic development, organogenesis, and adult neovascularization. Vasculogenesis can be mimicked and studied in vitro using network formation assays, in which endothelial cells (ECs) spontaneously form capillary-like structures when seeded in the appropriate microenvironment. While the biochemical regulators of network formation have been well studied using these assays, the role of mechanical and topographical properties of the extracellular matrix (ECM) is less understood. Here, we utilized both natural and synthetic fibrous materials to better understand how physical attributes of the ECM influence the assembly of EC networks. Our results reveal that active cell-mediated matrix recruitment through actomyosin force generation occurs concurrently with network formation on Matrigel, a reconstituted basement membrane matrix regularly used to promote EC networks, and on synthetic matrices composed of electrospun dextran methacrylate (DexMA) fibers. Furthermore, modulating physical attributes of DexMA matrices that impair matrix recruitment consequently inhibited the formation of cellular networks. These results suggest an iterative process in which dynamic cell-induced changes to the physical microenvironment reciprocally modulate cell behavior to guide the formation and stabilization of multicellular networks.
Circulating miRNA Profiling of Women at High Risk for Ovarian Cancer.

Abstract Survival of epithelial ovarian cancer patients remains poor without significant change over many decades. There is a need to better identify women at high risk (HR) for ovarian cancer. We propose that miRNA dysregulation may play critical roles in the early stages of ovarian cancer development. Circulating miRNAs may represent an important biomarker in this context, and miRNA profiling of serum in women at HR compared to those at low risk (LR) may give insights in tumor initiation pathways. There is also rationale for a specific focus on regulation of the androgen and its related hypoxia pathways in tumor initiation. We hypothesized that subsets of these pathway related miRNAs may be downregulated in the HR state. Serum from four HR and five LR women were sequenced and analyzed for 2083 miRNAs. We found 137 miRNAs dysregulated between the HR and LR groups, of which 36 miRNAs were overexpressed in HR and the vast majority (101 miRNAs or 74%) downregulated in the HR, when compared to LR serum. mRNA targets for the differentially expressed miRNAs were analyzed from three different miRNA-mRNA interaction resources. Functional association analysis of hypoxia and androgen pathway mRNA targets of dysregulated miRNAs in HR serum revealed that all but one of the miRNAs that target 52 hypoxia genes were downregulated in HR compared to LR serum. Androgen pathway analysis also had a similar expression pattern where all but one of the miRNAs that target these 135 identified genes were downregulated in HR serum. Overall, there were 91 differentially expressed miRNA-mRNA pairings in the hypoxia analysis. In the androgen-related analysis, overall, there were 429 differentially expressed miRNA-mRNA pairs. Our pilot study suggests that almost all miRNAs that are conserved and/or validated are downregulated in the HR compared to LR serum. This study, which requires validation, suggests that, via miRNA dysregulation, involvement of both hypoxia and its related androgen pathways may contribute to the HR state. This pilot study is the first report to our knowledge that studies circulating miRNA profiling of HR and LR women.
A case report – renal heavy chain amyloidosis and T-cell large granular lymphocytic leukaemia

As the diagnosis, pathology and patient characteristics are further recognized in heavy chain amyloidosis (AH), we continue to try to understand more about treatment and prognosis. We present a cas...
Life-Course Exposure to Neighborhood Poverty and Migration Between Poor and Non-poor Neighborhoods

Drawing on the life-course perspective, this study examines the effect of residential histories spent living in poor neighborhoods on the contemporaneous likelihood of moving between poor and non-poor neighborhoods. We use individual-level data from the Panel Study of Income Dynamics from 1970 to 2013 in conjunction with neighborhood-level data derived from four U.S. censuses. Results from logistic regression analyses show that a longer residential history spent in poor neighborhoods both reduces the likelihood of moving from a poor to a non-poor neighborhood and increases the likelihood of moving from a non-poor to a poor neighborhood. A decomposition analysis reveals that a sizeable portion of the racial differences in the likelihood of moving between poor and non-poor neighborhoods is attributable to differences between blacks and whites in the duration of time they have spent living in a poor neighborhood. Our study highlights the salient role of residential histories in perpetuating racial inequality in neighborhood poverty over the life course and across generations.
Making a racial difference: a foucauldian analysis of school memories told by undergraduates of color in the United States

This paper draws from the writings of Michel Foucault and his recently reconsidered provocations on race and racialization. Using Foucault’s definition of ‘internal racism,’ race is understood as a...
Design of a Multi-layered On-chip Wireless Power Transfer (WPT) System Design for Brain Neuromodulation Applications

Chronic pain is a common disease and as a negative consequence can cause paralysis to an individual in the long run. Noninvasive brain stimulation is an effective method to reduce pain in the short term. However, for long-term treatment, neural data analysis along with the stimulation is highly desirable. In this work, a unique multilayer spiral coil with a total dimension of $\mathbf{500}\ \mu\mathbf{m}\times\mathbf{500}\ \mu\mathbf{m}$ is designed in a $\mathbf{0.5}\ \mu\mathbf{m}$ CMOS process to make it suitable for a fully implantable system. The electrical modeling of the coil is also analyzed and simulated using Keysight's Advanced Design System (ADS) software to compare the theoretical modeling results with the simulation results. The electromagnetic (EM) simulation to characterize the on-chip coil in-terms of scattering parameters (S-parameters), $Q$ -factor, power transfer efficiency (PTE) is performed using the Ansys High-Frequency Structure Simulator (HFSS) software. The operating frequency of the WPT system is chosen to be within 402-405 MHz which is the Medical Implant Communication System (MICS) band. The simulated $Q$ -factor of the proposed on-chip coil is approximately 15 at 402 MHz. The on-chip coil is integrated with an on-chip seven-stage rectifier and some commercial off-the-shelf (COTS) components such as a DC-DC converter and a $\mu$ LED to design the complete optogenetic neuro-stimulation system. A minimum power transfer efficiency (PTE) of 0.4% is achieved through a 16 mm thick tissue media using the proposed WPT system. With that efficiency, the proposed system is able to provide constant power to light up a $\mu$ LED and proves to be a good candidate for neuromodulation applications.
"PEM Pals"-Cultivating a Learning Community During the Pandemic.

OBJECTIVES: The current pandemic has pushed medical educators to rethink traditional learning constructs as residents are experiencing fewer patient contacts in the pediatric emergency department (PED). Especially for those bound for a career in pediatric emergency medicine (PEM), we designed a curriculum to proactively address this emerging learning gap, incorporating a wellness "check-in" at the beginning of each session. The objective of this report is to share the themes of this wellness check-ins with those engaged in pediatric emergency medicine education and mentorship. Additionally, we share our curricular approach as we plan to continue PEM Pals after the pandemic restrictions are lifted. METHODS: "PEM Pals" is a twice-weekly video conference meeting made up of pediatric residents with an expressed interest in PEM and those residents currently on rotation in the pediatric emergency department. Following a flipped classroom model, participants complete a presession learning activity and then core PEM topics are covered through literature review, case discussions, and telesimulations. Each meeting begins with a wellness "check-in." Themes generated from these check-ins were member checked by our core learning contingent. RESULTS: Nine residents make up our core learning contingent and we have had 11 "PEM Pals" sessions since March 2020. Three themes emerged from the wellness check-ins. The first was each postgraduate year's unique concern over professional transitions. The second was a pervasive sense of guilt. And the third was a grave concern about their ability to support and be supported from their personal communities. CONCLUSIONS: The goal of our curriculum was to supplement an anticipated knowledge gap. Through use of a wellness "check-in," we elicited important themes for PEM educational leaders to consider as they mentor pediatric residents toward a career in PEM during the pandemic.
Creutzfeldt-Jakob Disease Masquerading as Autoimmune Encephalitis (P2.1-033)

Objective: Distinguishing between the causes of rapidly progressive dementia can be difficult, yet diagnostic clarity is important for treatment decisions and prognostication. Background: N/A Design/Methods: A 62-year-old woman from Minnesota presented with rapidly progressive gait instability. Two months prior to presentation, she had developed imbalance followed by lightheadedness, periodic tremulousness, nighttime headaches, and a marked decrease in energy and ability to walk. She was unable to continue her office job and stopped driving. Initial neuroimaging was unremarkable. During the next month, she developed binocular horizontal and vertical diplopia, somnolence, and worsening tremor and ataxia. Her husband noted memory decline and new violent jerking movements upon falling asleep. On exam, she had orthostatic hypotension, fine hand tremor bilaterally, square wave jerks, and an unsteady wide-based gait. Repeat MRI showed T2-hyperintensity in the right medial temporal lobe, right basal ganglia, and caudate. Cerebrospinal fluid (CSF) was non-inflammatory and infectious testing was negative. Autoimmune encephalitis panel in CSF and serum were unrevealing. Cancer screen with mammogram, colonoscopy and CT-PET scan was normal. Intravenous methylprednisolone was started for possible autoimmune limbic encephalitis, but she continued to worsen and was admitted to the general neurology service after a fall resulting in a wrist fracture. Repeat MRI showed cortical ribboning with T2-signal and diffusion imaging abnormalities in the caudate, thalamus, and hippocampus. CSF testing at the Prion Disease Laboratory revealed abnormally elevated RT-QuIC, total tau, and 14-3-3 protein highly suggestive of Creutzfeldt-Jakob Disease (CJD). Her husband disclosed that they occasionally hunt and eat wild game. She continued to rapidly decline and was transitioned to hospice care. Results: N/A Conclusions: We highlight a case of Creutzfeldt-Jakob Disease with mesial temporal T2-hyperintensity mimicking autoimmune encephalitis. Cerebrospinal fluid RT-QuIC is a useful highly specific confirmatory test for CJD. Disclosure: Dr. Kola has nothing to disclose. Dr. Flanagan has received research support from Medimmune. Dr. Jones has nothing to disclose.
A bioreactor for studying negative pressure wound therapy on skin grafts.

Negative pressure wound therapy (NPWT) has become the prevailing standard of care for treating complex soft tissue wounds and is now being considered for use in alternative applications including improving skin graft take. While it is generally agreed that negative pressure leads to improved wound healing, universal consensus on its optimal application is not supported in the literature. We describe the design and validation of a bioreactor to determine the prospective benefits of NPWT on skin grafts and engineered skin substitutes (ESS). Clinically relevant pressures were applied, and the native human skin was able to withstand greater negative pressures than the engineered substitutes. Both skin types were cultured under static, flow-only, and -75 mm Hg conditions for 3 days. While it remained intact, there was damage to the epidermal-dermal junction in the ESS after application of negative pressure. The normal skin remained viable under all culture conditions. The engineered skin underwent apoptosis in the flow-only group; however, the application of negative pressure reduced apoptosis. Vascular endothelial growth factor levels were significantly higher in the normal flow-only group, 152.0 ± 75.1 pg/mg protein, than the other culture conditions, 81.6 ± 35.5 pg/mg for the static and 103.6 ± pg/mg for the negative pressure conditions. The engineered skin had a similar trend but the differences were not significant. This bioreactor design can be used to evaluate the impacts of NPWT on the anatomy and physiology of skin to improve outcomes in wounds after grafting with normal or engineered skin.
Queering the Gaze: Visualizing Desire in Lacanian Film Theory

Film theorists typically conceptualize the gaze in film in terms of power and mastery. However, using Lacan’s notion of the gaze as the objet petit a, or an unattainable object that provokes desire, this essay examines the objet petit a as the foundation of an intersectional queer gaze, aligning queer identification with desire and mirroring the lack of mastery that spectators who are queer, female, or people of color experience. In applying Lacan’s invisible object that provokes our gaze as a lens through which to read queer existence and desire within discourses of queerness as “invisible” or an “open secret,” we can locate non-heterosexual identifications and desires and radical queer potential in the unseen spaces in film. Examining the films Safe (1995), Carol (2015), and The Watermelon Woman (1996), I identify and employ three forms of the queer gaze: reciprocal queer gazing, inclusive spectatorship, and re-visibility. These tools more successfully capture the mechanisms of queer gazing both on and offscreen, allowing us to better view queer cinema and spectatorship and disrupting the privileging of “representation” in contemporary LGBT discourse.
The role of the teaching assistant: Female role models in the classroom

Abstract We use a dataset of first-year engineering students from a selective research-intensive public university to examine the impact of same-gender teaching assistants on course grades and major field choice. Our sample consists of students who were randomly assigned to a section of an introductory engineering course and a graduate teaching assistant. Results suggest there may be small positive effects on course grades and the probability of majoring in a high-earning field for female students assigned to a female teaching assistant. Although the difference is marginally significant, the impact of a teaching assistant gender match for female students’ choice of a high-earning field is more pronounced in classrooms with a female instructor and above-median representation of female peers. Our results show limited evidence that female teaching assistants can provide the same benefits of a female instructor in STEM fields.
Stephen Jay Gould à la recherche du temps perdu

The Structure of Evolutionary Theory . By Stephen Jay Gould . Belknap (Harvard University Press), Cambridge, MA, 2002. 1457 pp. $39.95, £27.50, €45.90. ISBN 0-674-00613-5. In this magnum opus, Gould offers a history of the core concepts of Darwinism, considers recent critiques of these ideas, and provides a detailed account of his own synthesis of evolutionary theories.
Student Access of a Learning Management Site in Different Psychology Courses

The increased usage of technology in courses raises the question of whether students access the information posted on a learning management system (LMS). This study examined student access and exploration of an LMS across multiple psychology courses to evaluate student utilization of this resource in a manner similar to Clump, Bauer, and Bradley’s (2004) evaluation of student reading across multiple psychology courses. Across the courses, students consistently accessed information that can be classified as “course documents.” They were less likely to use other aspects of an LMS, such as a discussion board, without it being a course requirement or providing a means of communication. Previous research demonstrates students do not typically read course material, and it appears they are less likely to access course reading materials or web links related to class material.
The Economic Mythology of European Integration

This article examines the economic myths that surround the process of European integration. It argues that while such myths once played an important role in fostering identification and support for the process, they no longer serve that function. Instead, these economic myths have become a focal point for contestation and concern. Europeans will have to develop a new mythology to explain and justify their process of integration as a result.
Redefining the domains of decision making by physician and patient.

Over the past decades, physicians practising under a western bioethic responded to changing societal norms by letting go of strong paternalism and by embracing a heightened respect for patients' autonomy. Subsequent scholarly interest in physician—patient decision making is welcome because these normative and ethically progressive changes, nonetheless, have had some mixed effects on patient care and medical professionalism. For example, the medical profession, in distancing itself from such paternalism, also became uncertain about appropriate and functional paternalism and about responsibilities under the core ethical principle of non-maleficence - the obligation to not cause harms. This perspective essay aims to identify challenges pursuant to this changing relationship, and the work needed in this realm with the intention of benefitting patients and supporting physician professionalism.
Student Incivility: An Engagement or Compliance Model?

This critical essay describes two community college faculty members’ experience of student incivility in a learning community. Situated within the context of the tremendous recent growth in community college enrollment, the authors explore the negative consequences of heavy-handed, compliance based approaches to inappropriate student behaviors in the classroom. The authors “theorize up” from their classrooms on ways to address student incivility that motivate student agency and foster engagement in learning over simple compliance to rules. They propose several innovative interventions aimed at diminishing negative student behaviors and promoting student self-regulation in defining and enforcing civility on campus.
Recurrently Impulsed Resonators in Speech and Psychophysical Studies

The need for data on the perception of sounds produced by the excitation of resonance systems is discussed in relation to speech and psycho-acoustics. The voltage response of a series of N decoupled low-pass resonator sections to the sudden application of various types of input pulse trains is reviewed.The output of such a series of resonators to a recurrent impulse which is suddenly applied contains a d.c. term, a series of transient terms at the uncoupled resonator frequencies, and a steady-state term involving the harmonics of the input pulse train. A circuit for psychophysical tests is described which provides a number of discrete positions of resonator frequency and damping. Sound spectrographic analyses demonstrating the transient and steady-state terms for a single resonator are presented.
Chemical bases for medicinal plant use in Oaxaca, Mexico

Fifty-eight medicinal plants used for the management of reproduction and the treatment of women's reproductive health problems in an indigenous community in southern Mexico are described. The efficacy of these plants is assessed according to both community members' understandings of the therapeutic effects they seek and the standards of conventional Western medicine. The majority of the plants contain chemicals which would appear to enable them to accomplish their intended effects in either or both the popular and the conventional medical systems.
Femtosecond time-resolved spectroscopy of polarization dynamics in KNbO3

Femtosecond time-resolved impulsive stimulated scattering experiments were conducted on KNbO3 at temperatures spanning the orthorhombic phase. A heavily damped soft optic phonon mode associated with the displacive character of the transition and relaxational modes associated with order-disorder character were examined. Previous frequency-domain light scattering experiments had yielded conflicting results for the dynamics of the soft mode and the symmetry of the order-disorder motions. We find the relaxational motion to be of A1 symmetry and the soft mode to be the only low-frequency exictation of B2 symmetry. The soft mode is well described by a damped polariton model without any coupling to a relaxational mode. These results are consistent with a previously proposed eight-site model for the phase transitions.
Activation of metal–organic framework materials

Crystalline metal–organic frameworks (MOFs) have emerged as a highly desirable class of solid-state materials. Some of their most attractive features include exceptionally high porosities as well as surface areas. A key aspect to the realization of high porosity is the removal of guest molecules from the framework while still maintaining its structural integrity (i.e., “activation”). This contribution highlights the strategies utilized to date for activating MOFs, including: (i) conventional heating and vacuum; (ii) solvent-exchange; (iii) supercritical CO2 (scCO2) exchange; (iv) freeze-drying; and (v) chemical treatment.
Critical species of Odonata in North America

Abstract Of the approximately 439 species of Odonata known from North America, north of Mexico, comments on 25 species (6%) of conservation concern are given. Species deemed to be under the most threat are Ischnura gemina, Gomphus sandrius, Ophiogompbus australis, Stylurus potulentus, and Libellula jesseana. Two other species not under threat, Neurocordulia micbaeli and Somatochlora brevicincta, are briefly discussed because of their conservation interest. Some geographical clumping of species under threat is discussed, in southeastern Arizona, coastal New England, and the central Gulf of Mexico Coast.
12C(α, α) 12C resonance as a tool for quantitative analysis☆

With the use of a backscattering geometry, the elastic 12C(α, ga) 12C resonance at 4.265 MeV can produce an increment greater than one-hundredfold over the conventional Rutherford cross-section for carbon. In addition, the signal width is 70 keV, and can be used for depth profiling as a function of ion beam energy. A modified computer simulation program that takes into account the resonance scattering process can measure carbon-containing layers with a thickness of about 1 nm. Several examples that describe the applicability of the approach are given.
Bipolarity, multipolarity, and the future

Richard N. RoSeCranCe is Professor of Political Science at the University of California, Berkeley. A leading student of international systems and the dynamics that sustain and transform them, he has authored Action and Reaction in World Politics (1963) and Defense of the Realm: British Strategy in the Nuclear Epoch (1967), as well as edited The Dispersion of Nuclear Weapons (1966). In this selection Professor Rosecrance traces a structure of the global international system that falls midway between the contrasting structures identified in the two previous selections. His invigorating analysis should press the reader to reassess again the prevailing structure and stability of world politics in the nuclear age. [Reprinted from The Journal of Conflict Resolution, X (1966) 314-27, by permission of the author and the publisher. Copyright 1966 by the University of Michigan.]
The grammar of credibility assessment: A functional analysis of two legal questioning styles

Abstract Analysis of the rhetoric of attorney questioning has typically focused on the manipulative nature of questions and on the various mechanisms used by attorneys to influence the answers of witnesses. The analysis undertaken here investigates the notion that attorneys’ questions themselves create a representation of reality that constitutes a soty of meta‐testimony: a case within a case. This representation, operating independently of the answers given by witnesses, functions as a type of commentary on the credibility of the witness and the accuracy of prtrayals of events. The analysis suggests implications with regard to the role of attorneys and the process of a jury's assessment of evidence. The data under analysis is the examination questions asked during the sworn testimony of Andrea Wright, a witness in the Anita Hill/ Clarence Thomas hearings. A comparative analysis of questioning styles is undertaken with respect to process association, speech representation, and discourse label modification.
The House of IR: From Family Power Politics to the Poisies of Worldism

Poisies offers an alternative epistemology to understand, critique, engage with, and reconstruct international relations (IR). Generally, this Greek concept refers to “creativity” or “poetic inspiration.” We enlarge this definition by returning to poisies ' original, ancient meaning: that is, creativity that comes from an act of reverberation or putting “language in a state of emergence, in which life becomes manifest through its vivacity” (Bachelard 1964:xxiii). In seizing upon the specific reality of world politics as a trans-subjective mode of imagining, poisies pushes us to recognize that becoming and being have countless forms, various voices, and changing scripts. Consequently, we move beyond an instrumental, formalistic, fixed, and narrow scientific logic that imposes a historical parochialism (e.g., Hobbes's State of Nature) for an ahistorical universal (e.g., “it's a war of all against all across time and space”). We begin to see IR in a new light. Its “vivacity” is manifested through IR's political and ideological participation in world politics, accounting for the field's social relations and structural interests. This explains why conventional IR appeals to some the way it does while affecting so many others so negatively. International relation's singularity also becomes apparent: that is, it is but one of many versions and understandings of world politics. Specifically, IR comes to resemble a colonial household. Its singular, oppositional perspective (“I versus You”) stakes out an establishment of “civilization” in a space that is already crowded with local traditions of thinking, doing, and being but proclaimed, in willful arrogance, as a “state of nature” plagued by fearful “anarchy” and its murderous power politics. The House seeks to stave off such “disorder” by imposing “order.” But the House does so by appropriating the knowledge, resources, and labor of racialized, sexualized Others for its own benefit and pleasure while announcing itself the sole producer—the …