cssi/SciSciGPT-SciSciNet huggingface dataset:
Atypical Features in MECP2 P152R–Associated Rett Syndrome

Abstract Background Rett syndrome is a neurodevelopmental disorder that occurs in individuals with a mutation in the X-linked methyl-CpG-binding protein 2 ( 2MECP2 ) gene. 2MECP2 mutations produce a high degree of variability in the clinical phenotypes including the classic Rett features of head growth deceleration, psychomotor regression, deviant communicative ability, hand stereotypes, autonomic dysfunction, and seizures. Atypical forms of Rett such as those with preserved speech do not follow these characteristics. Patient We report a 9-year-old girl with atypical Rett (macrocephaly, preserved speech, and psychiatric manifestations) with a 2MECP2 (P152R) mutation that generally is not associated with these clinical signs. Conclusion This case broadens the genotype-phenotype correlation between the P152R mutation 2MECP2 -associated Rett syndrome.
TEMPORAL DURATION AS A FUNCTION OF INFORMATION PROCESSING

Estimation of duration has been shown to be a function of the amount and manner of organization of information processed during an interval. It was assumed that the use of an organizational schema to encode information reduces the actual amount of information stored. It was predicted that the use of an organizational schema will result in relatively shorter estimates of duration. Eighteen undergraduate subjects made estimates of intervals (.58 to 3.0 sec.) during which they watched film animations of moving geometric forms. In a second condition the same subjects were instructed to organize the animation as representing social interaction. An interaction showed that the use of an organizational schema to encode information resulted in smaller estimates for the longer intervals.
A Randomized Comparative Trial of Three Aminoglycosides???Comparison of Continuous Infusions of Gentamicin, Aaikacin and Sisomicin Combined with Carbenicillin in the Treatment of Infections in Neutropenic Patients with Malignancies

Continuous infusions of gentamicin, amikacin or sisomicin combined with carbenicillin were compared in a randomized study in the treatment of 572 febrile episodes in 281 patients with cancer. The three treatments (C+A, C+A and C+S) were equally effective with no significant differences in response rate overall (67%, 68%, 67%) or in any infection, except septicemia where C+G had a significantly lower response rate than the other two groups. Pneumonia, the most common infection, had the lowest response rate for all three groups (45-50%). Klebsiella spp. were the most common pathogens and showed a lower response rate than other gram-negative bacilli (P = 0.003). Patients with persistent severe neutropenia had a response rate of 56%. Azotemia was significantly less common in patients with documented infection treated with C+A than in the C+S group. Combinations of carbenicillin plus an aminoglycoside antibiotic are effective for the treatment of infections in neutropenic patients.
Single-incision laparoscopic sleeve gastrectomy versus conventional multiport laparoscopic sleeve gastrectomy: technical considerations and strategic modifications

Abstract Background Since its inception, minimal access surgery has been a dynamic field, experiencing successive leaps in technique and instrumental design. Each improvement in minimal access surgery must demonstrate that patients benefit from the change in approach, without compromising the outcome. The present study presents the technical considerations and strategic modifications for single-incision laparoscopic sleeve gastrectomy. We also compared the newly adopted single-incision laparoscopic approach with conventional multiport laparoscopic sleeve gastrectomy. Methods Of the 26 patients included in the present study, 14 underwent single-incision laparoscopic sleeve gastrectomy and 12 underwent conventional multiport sleeve gastrectomy. All procedures were performed by the same surgeon (A.A.S.) during a 12-month period from September 2008 to August 2009 at Michigan State University Kalamazoo Center for Medical Studies. Results The Mann-Whitney U tests showed with 95% confidence that the difference in pain scores and length of hospital stay in the single-incision laparoscopic sleeve gastrectomy group were statistically significant. A modest increase occurred in the operative time in the single-incision laparoscopic sleeve gastrectomy group. This difference was the least statistically significant of all variables ( P = .055). Conclusion Single-incision laparoscopic sleeve gastrectomy was associated with less postoperative pain, a lower need for analgesia, and a decreased length of hospital stay compared with conventional multiport laparoscopic sleeve gastrectomy. This was achieved without decreasing the quality of surgery or the outcomes offered by the conventional multiport counterpart.
Linear and nonlinear analysis of fluid slosh dampers

A vibrating structure and a container partially filled with fluid are considered coupled in a free vibration mode. To simplify the mathematical analysis, a pendulum model to duplicate the fluid motion and a mass-spring dashpot representing the vibrating structure are used. The equations of motion are derived by Lagrange's energy approach and expressed in parametric form. For a wide range of parametric values the logarithmic decrements of the main system are calculated from theoretical and experimental response curves in the linear analysis. However, for the nonlinear analysis the theoretical and experimental response curves of the main system are compared. Theoretical predictions are justified by experimental observations with excellent agreement. It is concluded finally that for a proper selection of design parameters, containers partially filled with viscous fluids serve as good vibration dampers.
Simplifying solution deployment on a Cloud through composite appliances

Containing runaway IT costs is one of the top priorities for enterprises. Cloud Computing, with its on-demand provisioning capability on shared resources, has emerged as a new paradigm for managing IT costs. In this paper, we describe a framework to simplify deployment of complex solutions on a Cloud infrastructure. We discuss the concept of a composite appliance and show how it can be used to reduce management costs. We illustrate the benefits of our approach with a complex three-tiered solution that can be deployed and configured on a set of virtual machines instances without any manual intervention.
Discordant Silurian paleolatitudes for central Newfoundland: New paleomagnetic evidence from the Springdale Group

Ancient remanences are retained by the Early Silurian (429 + 6/- 5 Ma) mafic volcamcs of the Sprmgdale Caldera (five sites) and the overlying red beds (seven sites) Dual polarity magnetizations are obtained by thermal demagnehzation of samples from the red beds, whereas single polarity d~rectlons are observed m the volcamcs High unblockmg temperatures indicate hematite as the remanence carrier m both the volcamcs and sedxments These h~gh-temperature, characteristic remanences are easily ~solated and pass both the tilt and conglomerate tests, they are likely to be of primary Silurian age Characteristic dechnatlons are predominantly northerly and northeasterly, and md~cate s~gmficant structural rotahons on a local scale When the results of the red beds and the voleamcs are combined they show characteristic mchnatlons that are shallower than those of the correlative Botwood Group (ca 36 ° vs 43 °) but not nearly as shallow as those reported from the King George IV Lake area (0 5 °) Mean mchnatlons obtained from the Sprmgdale red beds are, however, slgmficantly shallower than those of the Sprmgdale volcanlcs The same difference can be seen m other previous Silurmn paleomagnehc studies of central Newfoundland We infer that an mcllnat~on error affects the red bed magnetizations of the Sprmgdale Group, Botwood Group (Wigwam Formation) and rocks of the King George IV Lake area Therefore, the results from Sdurlan red beds should not be used to determine paleolahtudes for central Newfoundland The mean paleolatltude of the Sprlngdale Group volcamcs is 30 ° The mean paleolatltudes for both the Sprlngdale volcanlcs and Botwood volcamcs (Lawrenceton Formation) are md~stmgmshable w~thm paleomagnetlc error hm~ts from the predicted paleolatltude of Newfoundland on the northeast-trendi ng North American margin Thus, no detectable post-Silurian displacement ts shown by the volcamcs of the Sprmgdale Group with respect to cratomc North America.
Observations of intense velocity shear and associated electrostatic waves near an auroral arc

Simultaneous measurements of energetic particles and ac electric fields made by the javelin sounding rocket NASA 8:56 during the late expansion phase of a magnetic storm have revealed an intense shear in plasma flow of magnitude 20 (m/s)/m at the edge of an auroral arc. Structure with two characteristic scales sizes is displayed in the region of shear. Larger structures are of the order of several kilometers in size. Intense irregularities with characteristic wavelengths smaller than the scale size of the shear have also been detected. The large-scale changes in the orientation of the charge sheet at the edge of the arc may be due to the Kelvin-Helmholtz branch; shorter-wavelength modes may be related to the shear driven resistive drift wave. Observations are consistent with the suggestion that velocity shear instabilities may play a role in the formation of high-latitude irregularities.
PowerPoint in Public : Digital Technologies and the New Morphology of Demonstration

When policy issues involve complex technical questions, demonstrations are more likely to marshal charts, graphs, models, and simulations than to mobilize popular movements in the streets. In this paper we analyze PowerPoint demonstrations, the most ubiquitous form of digital demonstrations. Our first set of demonstrations are the PowerPoint presentations made in December 2002 by the seven finalist architectural teams in the Innovative Design competition for rebuilding the World Trade Center. Our second case occurred some blocks away, several months later: Colin Powell's PowerPoint demonstration at the United Nations. We argue that Edward Tufte's denunciation of PowerPoint does not capture the cognitive style made possible by the affordances of this pervasive new technology. On the basis of our case materials, we demonstrate the distinctive morphology of PowerPoint. Its digital character provides affordances (1) that allow heterogeneous materials to be seamlessly re-presented in a single format that (2) c...
Characterization of Salmonella-induced cell death in human macrophage-like THP-1 cells

Salmonella strains are facultative intracellular pathogens that produce marked cytopathology during infection of host cells. Different forms of cytopathic effects have been associated with the virulence systems encoded by the two Salmonella pathogenicity islands (SPI-1 and SPI-2) and the spv locus. We used Salmonella enterica serovar Dublin to investigate the induction of cytopathology during infection of the human macrophage-like cell line THP-1. Analysis of host cells by flow cytometry using a fluorescent terminal deoxynucleotidyltransferase dUTP-biotin nick end labeling (TUNEL) assay revealed that 70% of THP-1 cells showed DNA fragmentation after 4 h of infection, increasing to greater than 90% by 5.5 h. Moreover, the results showed that gentamicin-killed or chloramphenicol-treated bacteria did not induce DNA fragmentation. Serovar Dublin strains with mutations in SPI-1, SPI-2, or spvB induced these cytopathic effects similar to wild-type bacteria. In contrast, a mutation in the phoP regulatory gene abolished DNA fragmentation in the TUNEL assay. Caspase-3 activation was detected during Salmonella infection of THP-1 cells, but caspase-8 and caspase-9 activities were not found. However, inhibition of caspase-3 did not block Salmonella-induced DNA fragmentation. These results identify a previously undetected apoptotic effect in Salmonella-infected cells that is dependent on phoP gene function.
EFFECT OF PHYSIOLOGICAL MATURITY AT HARVEST ON PEACH QUALITY DURING LOW TEMPERATURE STORAGE

Peaches (cvs ‘Loring’ and ‘Redglobe’) were collected from five packinghouses within a 20 km radius on a single harvest date. Using color chips to categorize harvest maturity, fruit color and firmness were evaluated on the day of harvest. After 7 day storage at 5°C, designed to simulate maintenance of a cold-chain during wholesale distribution, peach color, firmness and sensory quality were determined. Color and flavor development were inhibited at 5° C but the softening rate increased at increasing levels of maturity. Separation of softening from flavor and color development has implications in study of ripening physiology of the peach and in assessing current handling practices.
Angle and space multiplexed holographic storage using the 90° geometry

The 90-degrees geometry - with reference and signal beams entering orthogonal crystal faces - is used to angularly multiplex up to 500 holograms at each of 8 spatially multiplexed locations in a LiNbO3 crystal. A segmented mirror array and a 2D mechanical scanner are used to perform both angular and spatial multiplexing. We show that this mirror array can be used with non-mechanical angle scanners, providing for holographic storage in multiple locations with no moving parts.
Discovery Of A Low-Mass Companion To The Solar-Type Star Tyc 2534-698-1

Brown dwarfs and low-mass stellar companions are interesting objects to study since they occupy the mass region between deuterium and hydrogen burning. We report here the serendipitous discovery of a low-mass companion in an eccentric orbit around a solar-type main-sequence star. The stellar primary, TYC 2534-698-1, is a G2V star that was monitored both spectroscopically and photometrically over the course of several months. Radial velocity observations indicate a minimum mass of 0.037 M⊙ and an orbital period of ~103 days for the companion. Photometry outside of the transit window shows the star to be stable to within ~6 millimags. The semimajor axis of the orbit places the companion in the "brown dwarf desert" and we discuss potential follow-up observations that could constrain the mass of the companion.
Chemie ‐ faszinierend oder ein Horrorfach? Zur Akzeptanz des Chemieunterrichts

EIN SEHR PERSONLICHER, nicht unpolemischer Beitrag zur heutigen Situation des Chemieunterrichts auf der S I-Stufe. Vorausgeschickt sei, das sich meine Bemerkungen zum Unterricht auf den Gymnasialunterricht beziehen. Allerdings komme ich nicht umhin festzustellen, das ich bei meinen zahlreichen Hospitationen in Deutschland ofters Realschulunterricht beigewohnt habe, dessen Niveau wesentlich hoher und anspruchsvoller war als bei Stunden in entsprechenden Gymnasialklassen.
Oscillatory behaviors in pharmacologically isolated heart interneurons from the medicinal leech

Abstract The central motor pattern for heartbeat in the medicinal leech is based upon the alternating bursting activity of mutually inhibitory pairs of heart interneurons (HNs). When pharmacologically isolated, these neurons spike tonically. Using a canonical model of an HN cell (Nadim et al., J. Comput. Neurosci. 2 (1995) 215–235) as a starting point, we generated three models, possessing different subsets of the currents exhibited by HN cells, that are capable of autonomous bursting behavior. These three models represent three different experimentally testable mechanisms that make HN cells potentially capable of bursting or generating slow oscillations under different ionic and pharmacological conditions. The three different mechanisms for producing bursting involve the interplay of: (1) fast Na+ current, leakage current and outward currents, (2) rapidly inactivating low-threshold Ca2+ current, leakage current and outward currents, and (3) slowly inactivating low-threshold Ca2+ current, leakage current and outward currents.
Commentary on: an alternative outpatient care model: postoperative guest suite-based care.

In their study, “An Alternative Outpatient Care Model: A Review of Safety in Body Contouring and Postoperative Guest Suites–Based Care,” the authors describe the Medallion Model for outpatient postoperative care.1 The Medallion Model provides postoperative care that is supervised by nurses in a hotel setting. Their review, a retrospective study, focuses on 246 patients who underwent body contour surgery. Major and minor complications requiring physician intervention within the first 30 days postoperatively were assessed. The authors point out that from 1996 through 2006, outpatient surgery visits increased from 20.8 to 34.7 million …
The Ship Appears to be Turning

Since early 2007, housing has experienced a prolonged slump in prices. This study investigates the state of housing markets across the United States as of June 2011 and finds that housing is undervalued in almost all markets. Two housing affordability measures (price-to-income ratio and mortgage payment-to-income ratio) show ownership is less costly today than during most of the nation's recent past. Additionally, a buy versus rent analysis suggests that ownership rather than renting is the preferable housing tenure choice from a financial standpoint in the majority of American real estate markets. These findings combine to indicate the presence of near term unprecedented opportunities for home ownership.
Event-based two degree-of-freedom control for micro-/nanoscale systems based on differential flatness

A new event-based two degree-of-freedom control method for micro-/nanoscale systems based on differential flatness is presented. Compared with traditional time-based feedback control, the proposed method shows great potential in dealing with measurement noise and unexpected disturbances. Instead of using time to drive the planner, we determine the reference trajectory with an intelligent event directly derived from measurement Therefore, the proposed method inherits the advantages of both feedback and feedforward. Applications to drug delivery demonstrate the promising robustness of this approach.
Low-Temperature PECVD SiO2 on Si and SiC

The deposition of SiO2 films by plasma-enhanced-chemical-vapor-deposition (PECVD) using tetraethylorthosilicate (TEOS) was studied. MOS capacitors were fabricated on both Si and SiC for this study. Several different sets of experiments were conducted for PECVD deposition according to different growth parameters and the results compared. For Si samples with SiO2 deposited at a substrate temperature 300°C, the C∼V curve gave a flat-band voltage of 1V and a transition slope of 112 pF/V. The dielectric constant of the deposited SiO2 film was 4.2 and the Si/SiO2 interface trap density was calculated to be 1.8×1010 cm−2. The I-V curve showed a leakage current density of l.2×10−9 A/cm2 and dielectric breakdown field strength of 9.2 MV/cm. For SiC samples, the PECVD deposition gave a uniform SiO2 film with a controllable deposition rate of 0.3nm/sec. The refractive index and dielectric constant of the as-deposited SiO2 film were 1.46 and 3.84 respectively. The I∼V curve showed a leakage current density of 2×10−9 A/cm2 and a breakdown field of 4.7 MV/cm.
Transrectal ultrasound guided versus digitally directed prostatic biopsy: a comparative study.

AbstractA total of 45 patients was evaluated with palpable prostatic nodules by digitally directed and ultrasonically guided biopsies. Of 14 patients with carcinoma tumor was detected by both techniques in 11. Of the remaining 3 patients 2 had positive findings only with the digitally directed biopsy and 1 only with the ultrasound guided biopsy. The study indicates that ultrasound guided prostatic biopsy is not necessary as a routine procedure when a distinct nodule is palpable.
Development of an outpatient clinic to provide pertussis vaccinations to maternity patients and family members

Purpose The implementation of a hospital-based outpatient pertussis prevention program targeting maternity patients and family members is described. Summary Faced with a rising incidence of pertussis statewide, a large Ohio hospital formed a multidisciplinary team to ensure hospital compliance with current guidelines calling for administration of the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine to all maternity patients as well as previously unvaccinated family members and likely neonatal caregivers (i.e., “cocooning”). The team had regularly scheduled meetings to identify and address fiscal, logistic, and practice-related challenges throughout the implementation process. Key challenges included (1) determining the availability of insurance reimbursement for Tdap vaccination services, (2) cultivating support for the vaccination initiative among obstetrics and maternal–fetal medicine specialists, (3) coordinating development and dissemination of educational information to patients and their families at specified points of contact, and (4) establishing an efficient registration process for family members. The outpatient vaccination clinic was located adjacent to the hospital’s maternity center in order to provide convenient access. Despite limited clinic hours (three hours daily on weekdays only) and ongoing reimbursement and funding challenges, the program has improved Tdap vaccination rates in the target population and is considered a successful demonstration of the cocooning concept. Conclusion Implementation of an outpatient clinic for neonatal pertussis prevention was well accepted by family members of newborns, and Tdap vaccinations were administered to 329 family members during the first 11 months of clinic operations.
Parallel Clustering of Protein Structures Generated via Stochastic Monte Carlo

The problem of efficient clustering of candidate protein structures into a limited number of groups is addressed. Such clustering can be expensive and is rarely used in practice due to its computational complexity. We present a parallel algorithm for the efficient clustering of proteins into groups. The input consists of thousands of candidate proteins structures that have been stochastically generated Monte-Carlo style. The first step is to make a Root Mean Square Deviation (RMSD) comparison matrix. The second step is to utilize parallel processors to calculate a hierarchal cluster of these proteins based on the RMSD matrix and using the Lance-Williams update algorithm. The final output is a Dendrogram of clusters. We have implemented our algorithm and have found it to be scalable.
Controlling Vertical Morphology within the Active Layer of Organic Photovoltaics Using Poly(3-hexylthiophene) Nanowires and Phenyl-C61-butyric Acid Methyl Ester

In this study, we demonstrate how the vertical morphology of bulk heterojunction solar cells, with an active layer consisting of self-assembled poly(3-hexylthiophene) (P3HT) nanowires and phenyl-C61-butyric acid methyl ester (PCBM), can be beneficially influenced. Most device fabrication routes using similar materials employ an annealing step to influence active layer morphology, but this process can create an unfavorable phase migration where P3HT is driven toward the top of the active layer. In contrast, we demonstrate devices that exhibit an increase in relative fullerene concentration at the top of the active layer by introducing the donor phase as a solid nanowire in the active layer solution and altering the pre-spin drying time. X-ray photoelectron spectroscopy and conductive and photoconductive atomic force microscopy provide detailed images of how the surface of the active layer can be influenced; this is done by tracking the concentration and alignment of P3HT and PCBM domains. Using this new pr...
Familial subtypes of childhood hyperactivity.

On the basis of family history data we defined two subtypes of childhood hyperactivity: family history-positive (FH+), in which at least one biological parent of the child had a diagnosis in the antisocial spectrum; and family history-negative (FH-), in which neither parent had such a diagnosis. Whi
Impaired Detoxification as a Mechanism of Lead Acetate-Induced Hypersensitivity to Endotoxin

SummaryActinomycin D was employed to profoundly enhance the sensitivity of mice to endotoxin in order to bioassay submicrogram amounts of endotoxin. Homogenates of rat liver and spleen were able to detoxify endotoxin as bioassayed in actinomyein-treated mice. Lung, kidney, heart, and brain homogenate did not possess the ability to significantly detoxify endotoxin. Lead acetate, which profoundly sensitizes rats to endotoxin, enhanced the vascular clearance of colloidal carbon and also reduced detoxification of endotoxin by liver and spleen homogenates. Enhanced phagocytosis, resulting in accumulation of endotoxin in macrophages, coupled with the failure in endotoxin inactivation or detoxification, appears to be the mechanism of lead acetate-induced endotoxin hypersensitivity.
The use of Focus Groups for Idea Generation: The Effects of Group Size, Acquaintanceship, and Moderator on Response Quantity and Quality:

Assumptions about focus group interviewing were tested. Individual interviews generated more ideas than focus groups, eight-member groups generated significantly more ideas than four-member groups,...
BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, IMPROVES ACTIVITIES OF MITOCHONDRIA COMPLEX-I AND COMPLEX-IV IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE

Dysfunctional mitochondria (MITO) lead to reduced ATP synthesis in LV myocardium of patients and animals with heart failure (HF). Bendavia (BEN, MTP-131), a first-in-class MITO targeting peptide, was shown to improve LV function and rate of MITO ATP synthesis in dogs with advanced HF. This study
Three-D Seismic Description of Volcanic Gas Pool:A Case Study from Exploration to the Lower Cretaceous Volcanics in Xujiaweizi Fault Depression,Northern Songliao Basin

Volcanic rocks,facies belts of volcanic edifices,reservoir prediction and hydrocarbon detection of Xujiaweizi fault depression are analyzed by using of full 3-D seismic data,and the detail description of the volcanic gas pools is made.According to eruptive types,the volcanic rocks of Xujiaweizi fault depression are classified into fissured type,central type and compound type.The volcanic rocks of fissured type have wedge outer shape with strong amplitude,low frequency and bad continuum.However,its inner characteristics are bad continuous reflection,middle-strong amplitude,parallel-diagonal structure.The volcanic rocks of central and compound type have mound outer shape with strong amplitude,low frequency and bad continuum.And their inner characteristics are blank-chaotic reflection.Volcanic edifices are divided into crater-near crater facies belts(CNCF),proxy facies belt(PF),distal faceis belt(DF) and volcanic-sedimentary facies belt(VSF).The CNCF has mound shape and chaotic reflection.The PF has bed reflection.The DF has bed shape and good continuum.The VSF has filling structure and good continuum.And volcanic facies belts can be recognized by using of coherence cube technique.According to the results of well-seismic integrated reservoirs inversion and hydrocarbon detection of attenuation attributes,the relative errors between reservoirs prediction results and new-well is decreased to 17.0%(the average value is 10.2%).The accuracy of hydrocarbon detection is increased to 75%.All above provide foundation for exploration of volcanic gas pools.
Experimental study on stability of Q420 angle steel compression members with high width-thickness ratio

Based on the compression test of 75 Q420 high strength equal-leg angle columns,the buckling behavior of such angle members were analyzed and their buckling models were summarized.The buckling strength of the specimens were compared with that according to the technical regulation of design for tower and pole structures of overhead transmission line in China.It showed that for the axial compression Q420 equal-leg angle columns with large slenderness,the flexural-torsional buckling failure mainly occurred,while for those with small slenderness,the local buckling failure mainly occurred.The test results of the buckling design reduction factor for angle columns were larger than that according to the Chinese technical regulation,and the test results showed that the reduction factor mN had relationship with the slenderness of columns,and the calculation equations were suggested.Based on the experimental study,it can be found that the buckling strength of Q420 high strength equal-leg angle columns is higher than that of ordinary angle steel.These research works can provide the basis for the study on the design method of high strength angle columns,and can also be helpful for the engineering application of Q420 high strength angles in tower structures.
Accounting Recognition for Transfers with Forward Agreements to Repurchase Financial Assets:Evolution Process and International Comparisons

Lehman Brothers used "Repo 105" to manipulate their financial statements,causing their bankruptcy. And thisevent indicates the significance of accounting recognition for transfers with forward agreements to repurchase financial assets.The former financial standards contain many defects,so that it is hard to recognize complicated repurchase transactions precise-ly. Reviewing the international evolution process of accounting recognition for those transfers,we can find that there are differ-ent advantages and disadvantages existed in related accounting standards,and that different issues arise when applying thesestandards. But there is no any perfect standard available in the world,so derecognition of the standards need modifications andglobal convergence. After making international comparisons of the thoughts of these standards,the paper makes recommenda-tions aimed to perfect accounting recognition for transfers with forward agreements to repurchase financial assets.
Genetic-Metabolic Considerations in the Sick Neonate

Inborn errors of metabolism that may appear in the first month of life are classified according to prominent symptoms. Screening tests that may be applicable to the detection of the relevant condition as well as secondary laboratory procedures usually available in most large hospitals or referral centers are indicated.
A novel mosquito ubiquitin targets viral envelope protein for degradation and reduces virion production during dengue virus infection.

Abstract Background Dengue virus (DENV) is a mosquito-borne flavivirus that causes significant human disease and mortality in the tropics and subtropics. By examining the effects of virus infection on gene expression, and interactions between virus and vector, new targets for prevention of infection and novel treatments may be identified in mosquitoes. We previously performed a microarray analysis of the Aedes aegypti transcriptome during infection with DENV and found that mosquito ubiquitin protein Ub3881 (AAEL003881) was specifically and highly down-regulated. Ubiquitin proteins have multiple functions in insects, including marking proteins for proteasomal degradation, regulating apoptosis and mediating innate immune signaling. Methods We used qRT-PCR to quantify gene expression and infection, and RNAi to reduce Ub3881 expression. Mosquitoes were infected with DENV through blood feeding. We transfected DENV protein expression constructs to examine the effect of Ub3881 on protein degradation. We used site-directed mutagenesis and transfection to determine what amino acids are involved in Ub3881-mediated protein degradation. Immunofluorescence, Co-immunoprecipitation and Western blotting were used to examine protein interactions and co-localization. Results The overexpression of Ub3881, but not related ubiquitin proteins, decreased DENV infection in mosquito cells and live Ae. aegypti . The Ub3881 protein was demonstrated to be involved in DENV envelope protein degradation and reduce the number of infectious virions released. Conclusions We conclude that Ub3881 has several antiviral functions in the mosquito, including specific viral protein degradation. General significance Our data highlights Ub3881 as a target for future DENV prevention strategies in the mosquito transmission vector.
The Consequences of International Regimes

The debate about whether international regimes matter is essentially over. Despite periodic rearguard actions (Mearsheimer 1994/1995) and occasional outbreaks of self-doubt, a consensus has emerged that regimes and more generally social institutions do make a difference—sometimes a big difference—in international society (Levy, Young, and Zurn 1995; Young 1999, Miles et al. 2002). Lest anyone be tempted to see this as the end of a line of enquiry, however, we hasten to point out that the emergence of this consensus opens up a large and important research agenda for those interested in the roles that institutions play in international society. While regimes matter, the ways in which they matter, the extent to which they matter, and the conditions under which they matter are variables whose values range widely over the universe of cases. Moreover, the effort to explain variance in these terms is fraught with a number of analytic and methodological problems ensuring that efforts to pin down the consequences of regimes under real-world conditions will remain high on the list of challenges confronting those engaged in research on international regimes during the foreseeable future.
Narrative theatricality: Joseph Conrad’s drama of the page

Joseph Conrad’s dramatic adaptation of his well-known novel The Secret Agent (1907) was first performed in 1922, that watershed year of modernist production, and it is striking in its attempts to translate the narrative’s innovative theatricality into the play’s literal theatre. That the translation largely fails is telling, to be sure, about Conrad’s limitations as a dramatist, but it is telling also about a misfit between the modernist content of Conrad’s novel, its analysis of national characteristics and the processes of affiliation, and the (mostly) realist form of Conrad’s play. The story fares better on the page than on the stage. Yet this is not because Conrad’s art surpasses or precludes the theatre. Rather, Conrad’s work absorbs the theatre too well: his narratives use theatrical metaphors that depend not on the absence of a stage, but on the ubiquity of staging. The Secret Agent is theatrical because it attributes the characteristics of natives and foreigners to the effects of social performance; but it is also anti-theatrical, because its theatre of culture resists the temporality of dramatic forms.
One laser for a cosmetic/dermatologic practice.

If you could only buy one laser,which one would you purchase andwhy? This is the most commonquestion my colleagues ask me. Toaddress this question, I must firstbegin with the disclaimer that I amor have been a consultant for,lectured for, performed workshopsfor, and/or received discountedequipment and/or research supportfrom many different laser companiesincluding Lumenis (formerly ESCand Coherent), CoolTouch, Cutera,Cynosure, Candela, ConBio, Sciton,and Syneron. I have also beeninstrumental in the development andinitial clinical testing of the pulseddye laser; Q-switched alexandritelaser; Ultrapulse CO
On-resin N-methylation circumvents a deletion peptide formed during the synthesis of cyclosporin analogs

Synthesis of Cyclosporin A where MeBmt = (4R)-4-[(2'E)-butenyl]-4,Ndimethyl-(L)-threonine); Sandimmune®, 1] has been carried out only in solution [1] even though solid phase methods offer many distinct advantages [2]. The seven sterically hindered N-methyl amino acids give rise to difficult peptide couplings, although the simple analog (2) was synthesized using a combination of solid-phase and solution-phase methods [3]. Here we show that the difficult coupling between the MeVal residue in the 11-position and the 1-position residue can be overcome to form (3) and (4), analogs of CsA with a -oxygen functionality as in MeBmt (Fig. 1).
Offline Social Relationships and Online Cancer Communication: Effects of Social and Family Support on Online Social Network Building

ABSTRACTThis study investigates how social support and family relationship perceptions influence breast cancer patients’ online communication networks in a computer-mediated social support (CMSS) group. To examine social interactions in the CMSS group, we identified two types of online social networks: open and targeted communication networks. The open communication network reflects group communication behaviors (i.e., one-to-many or “broadcast” communication) in which the intended audience is not specified; in contrast, the targeted communication network reflects interpersonal discourses (i.e., one-to-one or directed communication) in which the audience for the message is specified. The communication networks were constructed by tracking CMSS group usage data of 237 breast cancer patients who participated in one of two National Cancer Institute-funded randomized clinical trials. Eligible subjects were within 2 months of a diagnosis of primary breast cancer or recurrence at the time of recruitment. Findin...
Essay: Black Holes in the Lab?

If TeV-scale gravity describes nature, black holes will be produced in particle accelerators, perhaps even with impressive rates at the Large Hadron Collider. Their decays, largely via the Hawking process, will be spectacular. Black holes also would be produced in cosmic ray collisions with our atmosphere, and their showers may be observable. Such a scenario means the end of our quest to understand the world at shorter distances, but may represent the beginning of the exploration of extra dimensions.
Columbo, Cassavetes, and a biography of friendship

Through intertextual analysis, this article focuses upon the concept of friendship – the affective and relation dimensions of which function as a type of biographical narrative capable of being dis...
Inhibition of antigen presentation during AAV gene therapy using virus peptides

The clinical trial using adeno-associated virus (AAV) vector delivery of mini-dystrophin in patients with Duchenne Muscular Dystrophy (DMD) demonstrated a cytotoxic lymphocyte (CTL) response targeting the transgene product. These mini-dystrophin-specific T-cells have the potential to clear all transduced muscle, presenting the general gene therapy concern of overcoming the CTL response to foreign proteins that provide therapeutic benefit. In this study, we exploited a natural immunosuppression strategy employed by some viruses that results in CTL evasion only in transduced cells. After transfection of the plasmids encoding viral peptides and ovalbumin, which includes the immune-domain epitope SIINFEKL, several viral small peptides (ICP47 and US6) inhibited the SIINFEKL peptide presentation. A single AAV vector genome that consisted of either transgene AAT fused with SIINFEKL epitope and, separately, ICP47 expressed from different promoters or a single fusion protein with ICP47 linked by a furin cleavage peptide (AATOVA-ICP47) decreased antigen presentation. Compared with AAV/AATOVA in which decreased AAT expression was observed at late time points, persistent transgene expression was obtained after systemic administration of AAV/AATOVA-ICP47 vectors in mice. We extended this strategy to DMD gene therapy. After administration of AAV vector encoding human mini-dystrophin fusion protein with ICP47 into mdx mice, a lower mini-dystrophin-specific CTL response was induced. Importantly, the ICP47 fusion to mini-dystrophin inhibited CTLs mediated cytotoxicity. Although demonstrated herein using AAT and mini-dystrophin transgenes in an AAV context, the collective results have implications for all gene therapy applications resulting in foreign peptides by immune suppression in only genetically modified cells.
A Survey of a Freshman Medical Student Class: Will Psychiatry Recruit Well in the ’80s?

In a pilot assessment of recruitment potential for psychiatry in the 1980s, the authors surveyed a class of 90 entering medical school freshmen as to their background, demography, interests, and possible career choices. Of fifteen possible specialty choices, psychiatry ranked eighth in popularity, with fully 11% of the students expressing high interest and an additional 32% mild interest in psychiatry as their career choice. The class as a whole was clinically, humanistically, and altruistically oriented, and expressed most interest in “interpersonal” clinical specialties, of which family medicine was by far the number one choice. The authors review their findings in the light of the literature and statistics on psychiatric education, and conclude that, although one must be cautious about generalizing from only one class in only one school, a pool of interested students may well exist for ultimate recruitment to psychiatry in the ’80s. The authors suggest some strategies to research this issue further and to increase the likelihood that interest will be translated into actual specialty choice.
Designing an Organizational Readiness Survey for Total Worker Health® Workplace Initiatives

The aim of the present study was to develop a means to assess organizational readiness for a Total Worker Health® initiative, a comprehensive approach for improving employee safety health and wellbeing. A systematic literature review was conducted to integrate past multidisciplinary peer-reviewed theoretical and empirical work. Although the initial search of the organizational change literature revealed nearly 300,000 related titles, there was considerable conceptual ambiguity and only a limited number were focused on major occupational health and safety initiatives. A revised set of inclusion criteria identified 30 relevant publications that yielded the following eight key organizational characteristics and predictors: (1) culture, (2) communication, (3) leadership, (4) change history, (5) job design, (6) teams and relationships, (7) flexible organizational practices and policies, and (8) positive organizational climate. The findings from this review of the literature and our subsequent conceptual model provide the foundation for developing an organizational readiness assessment tool that researchers and practitioners will be able to use prior to implementing comprehensive workplace safety, health and wellbeing initiatives.
Secure Outsourcing of Matrix Convolutions

Due to the rapid growth of various systems and applications like cyber-physical systems, smart cities, and e-commerce systems, we have a massive volume of data collected from these systems and applications. We notice that matrix convolution is one of the most fundamental operations on largescale data, such as using it for image registration and object detection. However, performing large-scale matrix convolutions is usually time-consuming, hence hindering a general-purpose computer to conduct large-scale matrix convolutions by its own. Cloud computing allows using an economical way to ofﬂoad the most expensive computations to the cloud. This, however, obviously raise security concerns. To this end, we proposed an efﬁcient secure outsourcing scheme for large-scale matrix convolutions. Speciﬁcally, the user ﬁrst masks the matrices for protecting the security and sends the masked matrices to the cloud. Then, the cloud conducts matrix convolution and returns the result to the user. Finally, the user recovers the real result from the returned one. Particularly, the matrix convolution is performed in a non- interactive way, hence leading to the very low communication cost. We implement the proposed algorithm on the Amazon Elastic Compute Cloud (EC2) platform and a laptop. The experiment results show signiﬁcant time saving for the user.
Quickest Detection of Dynamic Events in Sensor Networks

We consider the problem of quickest detection of dynamic events in sensor networks. After an event occurs, a number of sensors are affected and undergo a change in the statistics of their observations. We assume that the event is dynamic and can propagate with time, i.e., different sensors perceive the event at different times. The goal is to design a sequential algorithm that can detect when the event has affected no less than η sensors as quickly as possible, subject to false alarm constraints. We design a computationally efficient algorithm that is adaptive to unknown propagation dynamics, and demonstrate its asymptotic optimality as the false alarm rate goes to zero. We also provide numerical simulations to validate our theoretical results.
Precision gain versus effort with joint models using detection/non‐detection and banding data

Capture-recapture techniques provide valuable information, but are often more cost-prohibitive at large spatial and temporal scales than less-intensive sampling techniques. Model development combining multiple data sources to leverage data source strengths and for improved parameter precision has increased, but with limited discussion on precision gain versus effort. We present a general framework for evaluating trade-offs between precision gained and costs associated with acquiring multiple data sources, useful for designing future or new phases of current studies.We illustrated how Bayesian hierarchical joint models using detection/non-detection and banding data can improve abundance, survival, and recruitment inference, and quantified data source costs in a northern Arizona, USA, western bluebird (Sialia mexicana) population. We used an 8-year detection/non-detection (distributed across the landscape) and banding (subset of locations within landscape) data set to estimate parameters. We constructed separate models using detection/non-detection and banding data, and a joint model using both data types to evaluate parameter precision gain relative to effort.Joint model parameter estimates were more precise than single data model estimates, but parameter precision varied (apparent survival > abundance > recruitment). Banding provided greater apparent survival precision than detection/non-detection data. Therefore, little precision was gained when detection/non-detection data were added to banding data. Additional costs were minimal; however, additional spatial coverage and ability to estimate abundance and recruitment improved inference. Conversely, more precision was gained when adding banding to detection/non-detection data at higher cost. Spatial coverage was identical, yet survival and abundance estimates were more precise. Justification of increased costs associated with additional data types depends on project objectives.We illustrate a general framework for evaluating precision gain relative to effort, applicable to joint data models with any data type combination. This framework evaluates costs and benefits from and effort levels between multiple data types, thus improving population monitoring designs.