cssi/SciSciGPT-SciSciNet huggingface dataset:
Two classes of excitatory synaptic responses in rat thalamic reticular neurons

The thalamic reticular nucleus provides feedforward and feedback inhibition to thalamocortical relay neurons. A minimal stimulation approach was used to isolate and characterize the two main excitatory inputs from the cortex and thalamus to this nucleus. Thalamic inputs were larger and had faster α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor kinetics, promoting rapid feedback inhibition, whereas cortical inputs were kinetically slower and recruited a greater contribution from N-methyl-d-aspartate receptors, leading to more integrative feedback.
A Brief Overview of the Systematics, Taxonomy, and Ecology of the Tuber rufum Clade

The Tuber rufum clade is one of the most speciose of clades in the Tuberaceae and is found in the Northern Hemisphere primarily in Asia, Europe, and North America. The species are ectomycorrhizal with angiosperms in neutral to high pH soils. The Rufum clade consists of an estimated 43 species, of which only 18 have been described. Molecular data suggests that five of the described species are species complexes: Tuber candidum, Tuber ferrugineum, Tuber lucidum, Tuber lyonii, and T. rufum. More than half of the undescribed species are from North America. Morphologically, the Rufum clade is characterized by smooth to minutely verrucose peridia and spiny to spiny-reticulate ascospores, although a few species are coarsely verrucose and one species has no spore ornamentation (Tuber melosporum). Tuber lyonii, from Eastern North America, is the only commercially valuable species. It remains to be seen if all species in the T. lyonii complex are commercially valuable.
Identifying and localizing network problems using the PuNDIT project

In today's world of distributed collaborations of scientists, there are many challenges to providing effective infrastructures to couple these groups of scientists with their shared computing and storage resources. The Pythia Network Diagnostic InfrasTructure (PuNDIT[1]) project is integrating and scaling research tools and creating robust code suitable for operational needs addressing the difficult challenge of automating the detection and location of network problems.PuNDIT is building upon the de-facto standard perfSONAR[2] network measurement infrastructure deployed in Open Science Grid(OSG)[3] and the Worldwide LHC Computing Grid(WLCG)[4]to gather and analyze complex real-world network topologies coupled with their corresponding network metrics to identify possible signatures of network problems from a set of symptoms. The PuNDIT Team is working closely with the perfSONAR developers from ESnet and Internet2 to integrate PuNDIT components as part of the perfSONAR Toolkit. A primary goal for PuNDIT is to convert complex network metrics into easily understood diagnoses in an automated way. We will report on the project progress to-date in working with the OSG and WLCG communities, describe the current implementation including some initial results and discuss future plans and the project timeline.
Validation of clinic weights from electronic health records against standardized weight measurements in weight loss trials.

Objective To validate clinic weights in electronic health records against researcher-measured weights for outcome assessment in weight loss trials. Methods Clinic and researcher-measured weights from a published trial (BE WELL) were compared using Lin's concordance correlation coefficient, Bland and Altman's limits of agreement, and polynomial regression model. Changes in clinic and researcher-measured weights in BE WELL and another trial, E-LITE, were analyzed using growth curve modeling. Results Among BE WELL (n = 330) and E-LITE (n = 241) participants, 96% and 90% had clinic weights (mean [SD] of 5.8 [6.1] and 3.7 [3.9] records) over 12 and 15 months of follow-up, respectively. The concordance correlation coefficient was 0.99, and limits of agreement plots showed no pattern between or within treatment groups, suggesting overall good agreement between researcher-measured and nearest-in-time clinic weights up to 3 months. The 95% confidence intervals for predicted percent differences fell within ±3% for clinic weights within 3 months of the researcher-measured weights. Furthermore, the growth curve slopes for clinic and researcher-measured weights by treatment group did not differ significantly, suggesting similar inferences about treatment effects over time, in both trials. Conclusions Compared with researcher-measured weights, close-in-time clinic weights showed high agreement and inference validity. Clinic weights could be a valid pragmatic outcome measure in weight loss studies.
Continuous-flow, electrically-triggered, single cell-level electroporation

Electroporation creates transient openings in the cell membrane, allowing for intracellular delivery of diagnostic and therapeutic substances. The degree of cell membrane permeability during electroporation plays a key role in regulating the size of the delivery payload as well as the overall cell viability. A microfluidic platform offers the ability to electroporate single cells with impedance detection of membrane permeabilization in a high-throughput, continuous-flow manner. We have developed a flow-based electroporation microdevice that automatically detects, electroporates, and monitors individual cells for changes in permeability and delivery. We are able to achieve the advantages of electrical monitoring of cell permeabilization, heretofore only achieved with trapped or static cells, while processing the cells in a continuous-flow environment. We demonstrate the analysis of membrane permeabilization on individual cells before and after electroporation in a continuous-flow environment, which dramatically increases throughput. We have confirmed cell membrane permeabilization by electrically measuring the changes in cell impedance from electroporation and by optically measuring the intracellular delivery of a fluorescent probe after systematically varying the electric field strength and duration and correlating the pulse parameters to cell viability. We find a dramatic change in cell impedance and propidium iodide (PI) uptake at a pulse strength threshold of 0.87 kV/cm applied for a duration of 1 ms or longer. The overall cell viability was found to vary in a dose dependent manner with lower viability observed with increasing electric field strength and pulse duration. Cell viability was greater than 83% for all cases except for the most aggressive pulse condition (1kV/cm for 5ms), where the viability dropped to 67.1%. These studies can assist in determining critical permeabilization and molecular delivery parameters while preserving viability.
Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review

Hemochromatosis is an autosomal recessive disorder which leads to abnormal iron deposition in the parenchyma of multiple organs causing tissue damage. Accumulation of iron in the brain has been postulated to be associated with several neurodegenerative diseases including Parkinson’s disease. The excess iron promotes Parkin and α-synuclein aggregation in the neurons. Excess iron has also been noted in substantia nigra on MRI especially using susceptibility weighted imaging in patients with Parkinson’s disease. We present a case of a young male with alleles for both C282Y and H63D who presented with signs of Parkinsonism and demonstrated significant improvement with levodopa treatment.
Dimensionality Reduction of Reactor Noise Signatures

A minimum-error linear transformation was applied to reduce the dimensionality of reactor noise signatures. The procedure improves the computational efficiency of processing algorithms and decreases bulk data storage requirements. The method was tested with noise signatures from the High-Flux Isotope Reactor at the Oak Ridge National Laboratory, and a dimensionality reduction in excess of 90 percent was achieved without loss in the average characteristics of the signatures.
Subjective and objective sleep discrepancy in symptomatic bipolar disorder compared to healthy controls.

Abstract Background Bipolar disorder (BD) is associated with sleep misperception. The objective of this study was to investigate the correlation between subjective and objective measures of sleep in persons with symptomatic bipolar disorder (BDS) compared to healthy controls (HC). Methods We studied 24 BDS and 30 HC subjects similar in age, race and sex. Subjective sleep was measured with Pittsburgh Sleep Quality Index (PSQI) and objective sleep with 7-days of actigraphy. Absolute discrepancy variables were calculated by subtracting objective sleep latency (SL) and total sleep time (TST) on actigraphy from their respective subjective estimates from PSQI. Mood symptoms were measured with Young Mania Rating Scale and Hamilton Depression Rating Scale. Results In the BDS group, subjective TST did not significantly correlate with objective TST, while it correlated in the HC group. The BDS group had significantly higher absolute discrepancy between subjective and objective SL and TST compared to the HC group. Multivariable regression analysis showed that severity of depression was associated with greater absolute discrepancy between subjective and objective TST within the BDS group. Limitations Subjects are from a tertiary care center and were on medications for treatment of BD symptoms. Conclusion There is low correlation between subjective and objective TST in BDS subjects and more severe depressive symptoms are associated with greater absolute discrepancy in TST. Objective rather than subjective measures of sleep, such as actigraphy, may be needed to evaluate sleep in BD subjects. Cognitive-behavioral interventions to address sleep misperception and associated depressed mood may be indicated in BD.
Eternal Perspective: Synthesis of Faith and Digital Printing in Creative Apparel Design

This apparel design collection combines origami techniques and digital printing to create an inspiring and faith-filled line entitled Eternal Perspective. The line was inspired by the designer's faith and the importance of always maintaining an eternal perspective. Flat patterning techniques were used to create origami garments which fold into a vortex, spiral, and diagonal stair steps in the completed garments. Two different digital prints were inspired by eternal ideas represented by images which were modified in Adobe Photoshop. The main print motif used is an altered image of stained glass windows on the San Diego LDS temple. A sunflower print was created as a visual representation of the mathematical Fibonacci sequence and then "engineered" in Adobe Illustrator to fit directly onto the pattern pieces. This engineering ensured that the motif would match up once the darts were sewn.
Fear of recurrence among older breast, ovarian, endometrial, and colorectal cancer survivors: Findings from the WHI LILAC study

OBJECTIVE To examine the prevalence of and factors associated with fear of recurrence (FCR) following treatment for breast, ovarian, endometrial, and colorectal cancer among older women. METHODS Participants were enrolled in the Women's Health Initiative Life and Longevity After Cancer study. Descriptive statistics and multivariate logistic regression models were used to assess the association of demographic, clinical, and quality of life variables with survivors' FCR, dichotomized as <14 (low) or ≥14 (high) using the Cancer Worry Scale. RESULTS Out of the 4259 participants, 3124 (73.3%) were diagnosed with breast cancer, 559 (13.1%) with colorectal cancer, 493 (11.6%) with endometrial cancer, and 83 (2%) with ovarian cancer. There were no significant differences in FCR by cancer type (P = .75), with a mean scale score of 10.8 ± 2.87 for all participants combined. Approximately 16% (n = 679) were in the high FCR group. Multivariable analyses indicated that being younger at diagnosis, reporting a symptom score of ≥8, receipt of chemotherapy, and lower self-rated health were significantly associated with high FCR. Women who were widowed or never married were less likely to report high FCR. CONCLUSIONS Fear of recurrence was experienced by a small but important proportion of older, long-term cancer survivors and is associated with multiple demographic and clinical variables. These results will better inform researchers and clinicians regarding the individuals who are at risk of FCR.
Modeling Dispersion of Emissions from Depressed Roadways.

Abstract This paper presents an analysis of data from a wind tunnel (Heist et al., 2009) conducted to study dispersion of emissions from three depressed roadway configurations; a 6 m deep depressed roadway with vertical sidewalls, a 6 m deep depressed roadway with 30° sloping sidewalls, and a 9 m deep depressed roadway with vertical sidewalls. The width of the road at the bottom of the depression is 36 m for all cases. All these configurations induce complex flow fields, increase turbulence levels, and decrease surface concentrations downwind of the depressed road compared to those of the at-grade configuration. The parameters of flat terrain dispersion models are modified to describe concentrations measured downwind of the depressed roadways. In the first part of the paper, a flat terrain model proposed by van Ulden (1978) is adapted. It turns out that this model with increased initial vertical dispersion and friction velocity is able to explain the observed concentration field. The results also suggest that the vertical concentration profiles of all cases under neutral conditions are best explained by a vertical distribution function with an exponent of 1.3. In the second part of the paper, these modifications are incorporated into a model based on the RLINE (Snyder et al., 2013) line-source dispersion model. While this model can be adapted to yield acceptable estimates of near-surface concentrations (z
The Personality of the Worker: An Unexplored Dimension in Treatment:

The influence the caseworker's personality has on transference and the manner in which worker vulnerability and client behavior function to affect countertransference are considered in a conceptual...
Real-time alerting of flight status for non-aviation suppliers in the air transportation system value chain

The air transportation system has a broad and deep value chain. Some of the stakeholders are directly part of the air transportation system and use real-time flight, airport and air traffic control data as part of their operations. Other stakeholders are several layers removed and do not have access to system status even though it impacts their business. For these stakeholders it may be outside their core competency or cost prohibitive to purchase access to a data feed and the required hardware/software infrastructure to support real-time status alerting. In many cases, the need for status alerting is only temporary (e.g. seasonal, during period of construction, or transition to new gate leasing arrangement). This paper describes a low-cost software application that can be deployed to provide real-time alerts to stakeholders whose operations are directly impacted by flight and system status changes, but cannot afford to maintain their own status alerting system. The flight status alerting system described in this paper can be configured over the web and transmits alerts via email or text messages to the cell phones of employees. Case studies are provided for: (1) alerts to adjust staffing at an airport food concession for forecast irregular operations (to generate an estimated $46K to $121K in additional annual profit), (2) alerts to investigate excessive taxiin times and gate utilization compliance. Implications and limitations of the system are discussed.
Setting up a Laboratory

Publisher Summary This chapter focuses on various aspects of running a clinical laboratory. It mentions that clinical laboratory testing should follow regulations and comply with standards. The concerns about test quality led to the Clinical Laboratory Improvement Amendments of 1988 (CLIA’88) regulations that oversees all aspects of testing in most clinical laboratories. According to CLIA, a clinical laboratory must undergo inspection every two years and must engage in proficiency testing for every analyte for which testing is offered. The Health Insurance Portability and Accountability Act (HIPAA) include provisions for ensuring the privacy of patient information including test results. An issue in molecular genetics laboratories is mentioned to be the minimization of risk of contamination by amplicons from polymerase chain reaction (PCR). The traditional applications of radioactivity can be performed by non-radioactive methods and long range PCR can replace some southern blot applications. The clinical testing process is described and involves three phase: pre-analytical, analytical and post-analytical. The sample handling, specimen handling and specimen processing are further discussed.
An Automated Two-Crystal Spectrometer Employing Direct Angular Positioning and Readout

A unique approach has been used in the construction of a vacuum-two-crystal spectrometer. The instrument uses digital shaft encoders directly coupled to the analyzing crystal axes to give accurate absolute angular measurement over a 360° revolution of each crystal. Each axis is driven directly by a torque motor tachometer combination which allows precise speed and position control. The complete two-crystal carriage assembly rotates about the first crystal axis, thus permitting the x-ray tube to be fixed to the vacuum chamber. The carriage and detector rotations are driven through antibacklash gearing by smaller shaft encoder, torque motor, tachometer assemblies. Because the complete unit is housed within the vacuum chamber, there are no alignment changes on system pump-down. The spectrometer is part of a completely automated computer controlled system. The computer is used for data acquisition and analysis as well as for controlling the angular position of the analyzing crystals, detector, and carriage.
Specialty Choices of Women Physicians

Why certain physicians choose particular specialties and others choose different specialties is somewhat of a mystery. “Even the most sophisticated work has failed to account for the specialty of a majority of the sample”.(GMENAC Staff Paper) When senior medical students were asked why they chose the specialty of their upcoming first year of residency, both men and women gave similar reasons (Cuca). Opportunities for self-fulfillment topped the list, positive clinical experiences was next followed by the intellectual challenge of the subject matter of the specialty and the type of patient. The two factors with the greatest difference between men and women were financial advantage, which was slightly more important to men, and type of patient, which was slightly more important to women. Thus, men and women give similar reasons for choosing specialties, yet they choose different ones.
Third Nerve Palsy as the Presenting Sign of Metastatic Endometrial Carcinoma with Lymphovascular Space Invasion

We present a case of endometrial carcinoma (EC) presenting with a third cranial nerve palsy due to metastasis to the cavernous sinus. Although the tumour was only stage 1B, histopathologic features including higher grade and lymphovascular space invasion (LVSI) increase the risk of recurrent and metastatic disease. To our knowledge, this is the first case of EC presenting as a third cranial nerve palsy in the English-language ophthalmic literature. Clinicians should be aware that the risk of metastatic EC including neuro-ophthalmic presentations depends upon not only stage and grade but also the presence of unique histopathological findings such as LVSI.
The Manganese-Based Zirconium (Zr) and Chromium (Cr) Polymeric Pillared Interlayered Montmorillonite for the Low-Temperature Selective Catalytic Reduction of NO x by Ammonia (NH 3 ) in Metallurgical Sintering Flue Gas

The manganese-based Zr and Cr polymeric pillared interlayered montmorillonite (Mn/Zr-Cr-PILM) with various Zr/Cr ratio as carrier supported MnOx were used in the selective catalytic reduction of NOx by NH3 (NH3-SCR) in metallurgical sintering flue gas. The X-ray diffraction (XRD), N2 adsorption–desorption isotherm, and ammonia temperature-programmed desorption (NH3-TPD) were used to analyze the catalyst physicochemical property. The Mn/Zr-Cr-PILM (1:3) had the highest NOx conversion between 140 and 180 °C compared with other catalysts. This was due to the large specific surface area and a large amount of Lewis acid sites provided more reaction platform and more adsorption sites for the catalytic reaction. However, as the proportion of Cr increased in Mn/Zr-Cr-PILM, the N2 selectivity of the catalyst decreased rapidly with the increasing temperature, except for Mn/Zr-Cr-PILM (3:1). It may be that the entry of chromium oxide into the zirconium oxide crystal phase in Mn/Zr-Cr-PILM (3:1) inhibited the production of N2O for increasing the N2 selectivity.
Optogenetic perturbation of the biochemical pathways that control cell behavior.

Abstract Optogenetic tools provide a level of spatial and temporal resolution needed to shed new light on dynamic intercellular processes. In this chapter we outline specific protocols for applying these tools to cell motility (optogenetic cofilin), apoptosis [optogenetic Bcl-like protein 4 (Bax)], and protein kinase-mediated signaling pathways [optogenetic cAMP-dependent protein kinase (PKA)]. The activity of these optogenetic species is regulated by the light-mediated dimerization of a cryptochrome/Cib protein pair, which controls the intracellular positioning of the protein of interest. The light induced recruitment of cofilin to the cytoskeleton is utilized for directed migration studies and filopodial dynamics. Light-triggered migration of Bax to the outer mitochondrial membrane induces cellular collapse and eventual apoptosis. Finally, the light-mediated movement of PKA to specific intracellular compartments offers the means to assess the consequences of PKA activity in a site-specific fashion via phosphoproteomic analysis.
Reconstruction methods and analysis of subsurface uncertainty for anisotropic microstructures

Abstract In the present work, strain localization at the surface of a heavily textured material is modeled, where the subsurface microstructure was statistically reconstructed via a proposed methodology that directly uses the information given by the surface characterization. The elasto-viscoplastic simulations based within a fast Fourier transformation formulation (EVP-FFT) were compared with digital image correlation quantification of strain coupled with electron backscatter diffraction characterization of the microstructure to produce strain maps of the surfaces, and the in-plane maximum shear strain was evaluated. When modeling specimens from rolled plate of AA7050 material, both with and without a 3D subsurface reconstruction, a reasonable improvement was observed when a statistically reconstructed subsurface morphology was included in the simulations (regardless of grain morphology or orientation distribution) since it allowed the surface grains to redistribute and accommodate deformation along the third dimension. Additionally, when performing a case study on fabricated specimens that exhibited a through thickness grain structure, in order to minimize the subsurface uncertainty, the model's ability to capture the strain localization improved, thereby confirming the importance of capturing the subsurface microstructure on the surface response. These results therefore quantify the effect of the subsurface grain structure on the surface strain fields and thereby present a path forward for performing crystal plasticity simulations by presenting a subsurface reconstruction methodology based on surface characterizations.
Optimization of Polydopamine Coatings onto Poly-ε-Caprolactone Electrospun Fibers for the Fabrication of Bio-Electroconductive Interfaces.

In recent years, mussel adhesive proteins have attracted much attention because they can form strong adhesive interface interactions with various substrates in a wet environment. Inspired by their catechol- and amine-based molecular structure, polydopamine (PDA), a dopamine derived synthetic eumelanin polymer, was recognized as a suitable bio-interface coating. PDA was successfully used to improve adhesion due to the availability of copious functional groups for covalently immobilizing biomolecules and anchoring reactive species and ions. Recently, it has been demonstrated that PDA and its derivatives can be successfully used for the surface modification of implants interfaces to modulate in vitro cellular responses in order to enhance the in vivo functionality of biomedical implants (i.e., prosthesis). Herein, we propose the development of multifunctional scaffolds based on polye-caprolactone (PCL) electrospun fibers coated with PDA via electro fluid dynamic methods, by optimizing polymerization/oxidation reactions capable of driving PDA self-assembly, and, ultimately, investigating the effects on cell response. Morphological analyses have confirmed the possibility to obtain different surface topographies as a function of the coating process while in vitro studies proved the ability of PDA coating to interact with cells no compromising in vitro viability. In perspective, in vitro conductive properties of fibers will be further investigated in order to validate their promising use as bioconductive interfaces for tissue engineering applications.
4.41 – Neurogenesis

Adult neurogenesis is a process that is unique to two regions of the brain – the dentate gyrus and the subventricular zone. This chapter summarizes the underlying biology of lifelong neurogenesis in the dentate gyrus, including the role of adult neural stem cells and their differentiation process into neurons and ultimate maturation into fully functional granule cells. Furthermore, we discuss the numerous factors known to regulate the levels of adult neurogenesis. Finally, this chapter summarizes the current experiments and theories explaining a functional role for neurogenesis.
Ambient Scent as a Positive Distraction in Long-Term Care Units: Theory of Supportive Design

Aim:This study was designed to explore the associations between an ambient scent environment and residents’ wellness in long-term care facilities.Background:The number of older adults living in an ...
Resistin family proteins in pulmonary diseases

The family of resistin-like molecules (RELMs) consists of four members in rodents (RELMα/FIZZ1/HIMF, RELMβ/FIZZ2, Resistin/FIZZ3, and RELMγ/FIZZ4) and two members in humans (Resistin and RELMβ), al...
Faith as Political Epistemology: A Review of Tim Leonard's Illiberal Reformers: Race, Eugenics, and American Economics in the Progressive Era

In this review of Tim Leonard's remarkable book Illiberal Reformers, Race, Eugenics, and American Economics in the Progressive Era, I argue that, having defined progressivism as a political epistemology of faith in the powers of policymaking, Leonard did not follow up several of the interesting implications of this definition. This is less a critique of Leonard, whose interests, quite reasonably, are likely to lie elsewhere, than a personal lament and a call for inquiry into these unexamined implications.
Peripheral Neural Regulation of the Laryngopharynx

Peripheral neural regulation of the laryngopharynx involves a complex sequence the laryngopharyngeal sensitivity receptors, triggering conscious or reflexive perception through the peripheral course of the vagus nerve. Laryngopharyngeal sensitivity receptors include the nociceptor bronchopulmonary C-fibers, mechanoreceptor (Widdicombe) cough receptors, transient receptor/ion channel potential vanilloid (TRPV), rapidly and slowly adapting receptors (RAR and SAR, respectively).The latter involves nuances of the right and left recurrent laryngeal nerves, in addition to the superior laryngeal nerves.
African footballers’ wives: “Those paid dollars and pounds, their head is not five!”:

Marrying a footballer may be perceived as exotic, going by the popularity of footballers, but as some studies note, coping with lives of footballers who migrate frequently is challenging. Life as t...
Predicting lineage-specific differences in open chromatin across dozens of mammalian genomes

ABSTRACT Many phenotypes have evolved through gene expression, meaning that differences between species are caused in part by differences in enhancers. Here, we demonstrate that we can accurately predict differences between species in open chromatin status at putative enhancers using machine learning models trained on genome sequence across species. We present a new set of criteria that we designed to explicitly demonstrate if models are useful for studying open chromatin regions whose orthologs are not open in every species. Our approach and evaluation metrics can be applied to any tissue or cell type with open chromatin data available from multiple species.
Journal Club: Diffusion-weighted MRI in Transient Global Amnesia and its Diagnostic Implications

The term transient global amnesia (TGA) was introduced by C. Miller Fisher and Raymond D. Adams in 1958 to describe a condition characterized by the abrupt onset of dense anterograde amnesia, followed by a return to normal cognition after a number of hours.1 TGA's underlying pathogenic mechanism remains a matter of debate,2 but transient dysfunction of brain regions deputed to memory, especially the hippocampus, appears to play a central role.2 While TGA is associated with delayed appearance (24–48 hours from symptom onset) of hippocampal lesions on diffusion-weighted imaging (DWI) magnetic resonance studies,3 diagnosis remains completely clinical, is based on diagnostic criteria established by Hodges and Warlow in 1990,4,5 and requires either direct observation of transient anterograde amnesia by a clinician or collateral from a capable observer who witnessed the episode.
Spiraling into Design Inspiration

This design, Spiraling into Design Inspiration, is an outcome of a continued investigation of the use of this spiral zero waste pattern. This pattern indirectly resulted from the investigation of Sanah Sharma’s Planar Flux Hybrid Clothing Technique. Patterns that are developed from a spiral reduce the amount of fabric needed to develop a garment, (Shama 2015). Looking for an innovative technique that would provide a sustainable solution to address pre-consumer textile waste, a double spiral pattern was developed that resembles a yin-yang. This pattern was used in several previous designs and the only vision for this design was to use the same basic pattern to create a jacket with voluminous sleeves accompanied with a skirt. There was no other preconceived concept for the design outcome prior to the draping of the separated spirals onto the half-scale form.
Results from Project GOLD: A pilot randomized controlled trial of a psychoeducational HIV/STI prevention intervention for black youth

Black youth face significant disparities in HIV/sexually transmitted infection (STI) disease burden. Mental illness and emotion regulation are ontributors to HIV/STI risk, yet many HIV/STI preventi...
DNP scholarly projects: Unintended consequences for academic-practice partnerships

Abstract With the rapid proliferation of Doctor of Nursing Practice (DNP) programs, academic-practice partnerships are critical in the implementation of rigorous and valuable scholarly projects. However, the failure to develop meaningful partnerships can have unintended consequences, particularly when students and practice sites do not have the preparation and support to navigate these partnerships. Four case studies are presented that explore the issues of preserving autonomy, practicing stewardship, imposing unfair burden and maintaining project fidelity. Best practices are presented to promote equitable collaboration and a mutually beneficial experience. Universities must have the resources required to generate expert clinicians able to translate research into practice and support effective academic-practice partnerships.
Stay Connected in An Immersive World: Why Teenagers Engage in Social Virtual Reality

Social virtual reality (VR) has emerged as a popular online space for teenagers to interact and socialize. It attracts teens due to the broad range of immersive activities and social engagement opportunities, along with diverse users in terms of age and interest. Yet, little is known about teenagers’ experiences and understandings of this emerging online social space, especially regarding what aspects may attract or dissuade them to social VR. To explore this question, we conducted in-depth interviews with 20 teenagers (e.g., ages 13-18) and reported findings regarding what attracted them to engage in social VR and challenges with social VR that may dissuade them from using it. Our findings contribute to the growing body of scholarship on teenagers’ experiences in emerging, novel online social spaces and highlight potential design implications for creating safer and more fulfilling social VR experiences for teenagers.
Income Mobility and Risk During the Business Cycle: Comparing Adjustments in Labor Markets in Two Latin-American Countries

This paper uses panel data from Argentina and Mexico and a new measure of mobility - the Gini index of mobility - to answer three questions. First, is there a trend towards rising labour income mobility over time in these two countries? Second, is there a relationship between income mobility and growth common to both countries, or does that relationship depend on the institutional features of each country's labour markets? Third, do we observe more labour income mobility within some groups such as the young and the less educated than within other groups?
Acute hypophosphatasemia

Summary The temporal evolution of a low serum alkaline phosphatase value may relate to its cause. Precipitous lowering of serum alkaline phosphatase below the lower range of normal is uncommon and may indicate severe physiologic stress and increased short-term mortality.
A model of eddy current nondestructive evaluation for a current leaking crack

Abstract This paper presents a model-based study of undesirable signal loss problems, often encountered by eddy current inspections of tight cracks. Possible current leakage through a portion of the crack face is the focus here as the principal mechanism of signal reduction. Two problematic types of cracking conditions are studied particularly, i.e., a surface-smeared crack and a crack under compressive stress. With a newly developed model and its numerical results, the paper shows quantitative analyses of the signal loss for the above two cases, compared to the response of a pristine surface-breaking crack in the similar geometrical configuration.
Evaluation of a rheumatology patient prioritization triage system

Purpose Patient triage systems have been used to prioritize referred patients to facilitate timely treatment of acutely ill patients, but there is limited data to support the effectiveness of these systems as implemented in the clinic setting. Therefore, the purpose of this study was to evaluate the accuracy of a specialty provider triage system. Data sources A prospective study design was conducted (N = 103) to compare the pre- and postappointment provider-assigned, prioritization system acuity scores. The intraclass correlation coefficient (ICC), paired t-test, and the Bland–Altman plotting method were used to summarize and analyze the data. Conclusions The ICC between the pre- and postappointment acuity scores was 0.50 (p < .001) with no significant difference between the average means (t = −1.17; p = .24). The Bland–Altman plot suggests scores were typically within the limits of agreement. Our findings suggest the specialty provider triage system was effective at accurately classifying rheumatologic patient acuity in this sample. Implications for practice When resources are limited and delayed evaluations and treatments result in negative health outcomes, the use of triage systems is likely an effective strategy to reduce the impact of limited provider availability relative to patient census.
Environmental Assessment for the NASA First Response Facility

NASA intends to construct a First Response Facility for integrated emergency response and health management. This facility will consolidate the Stennis Space Center fire department, medical clinic, security operations, emergency operations and the energy management and control center. The alternative considered is the "No Action Alternative". The proposed action will correct existing operational weaknesses and enhance capabilities to respond to medical emergencies and mitigate any other possible threats. Environmental impacts include are emissions, wetlands disturbance, solid waste generation, and storm water control.
Early Aggregated States in the Folding of Interleukin-1β

Kinetic data measured from folding of the protein interleukin-1β fits best to three exponential phases when studied with tryptophan fluorescence but only two exponential phases when measured using other methods. The technique of ANS fluorescence was used to determine whether the additional phase observed in tryptophan fluorescence was also detected with ANS dye binding. Unlike trytophan fluorescence, the ANS fluorescence was highly dependent on the concentration of protein present during the folding experiment. Experimental controls provide evidence that ANS binds to protein aggregates, present at higher concentrations and absent at lower concentrations. Protein concentration-dependent folding studies demonstrate that, at lower interleukin-1β concentrations, tryptophan fluorescence kinetics can be fit adequately with a two exponential fit. This study indicates that (1) measured interleukin-1β folding kinetics fit to a 2 phase model and (2) at higher protein concentrations, transient association of IL-1β may result in a kinetic fit of 3 phases.
An Implementation of Queues

One of the most common data structures in programs is the queue, which is used frequently as a buffer between processing elements.
A heuristic algorithm for multiple sequence alignment based on blocks

Blocked multiple sequence alignment refers to the construction of multiple alignment by first aligning conserved regions into what we call “blocks” and then aligning the regions between successive blocks to form a final alignment. Instead of starting from low order pairwise alignments we propose a new way to form blocks by searching for closely related regions in all input sequences, allowing internal spaces in blocks as well as some degree of mismatch. We address the problem of semi-conserved patterns (patterns that do not appear in all input sequences) by introducing into the process two similarity thresholds that are adjusted dynamically according to the input. A method to control the number of blocks is also presented to deal with the situation when input sequences have so many similar regions that it becomes impractical to form blocks by trying every combination. BMA is an implementation of this approach, and our experimental results indicatethat this approach is efficient, particularly on large numbers of long sequences with well-conserved regions.
Immunization of C58 mice to line Ib leukemia.

exposed to UV light for 15 to 30 minutes was the most immunogenic. A dose of 10s cells per ml was only weakly immunogenic. A dose of IO8 UV-irradiated cells killed all of the recipient mice. However, when IO8 cells were exposed to 15,000 R of X-irradiation they were strongly immunogenic ; a 10s cell dose exposed to 5,000-15,000 R was not immunogenic. A preparation of IO7 cells per ml exposed to 5,000-15,000 R was the most immunogenic. The optimum method for inactivating cells with formalin was by exposure to a 1:500 dilution for 18 hours at 4Â°C.A dose of IO7 cells per
Has the 1987 crash changed the psyche of the stock market

Purpose – The purpose of this paper is to utilize the initial public offerings (IPO) market to research the effect the stock market crash of 1987 had on the market psyche.Design/methodology/approach – The paper compares the number of IPOs, as well as accounting data during the years surrounding the 1987 crash to determine if there is a change in financial quality. The underwriting fee structure, underpricing and short term price changes during one year prior to and one year following the 1987 crash are examined, as well as the long term returns surrounding the crash.Findings – The stock market crash of 1987 did change the market psyche in the short to medium term. Results show greater risk aversion in the post crash period, as evidenced by fewer IPOs from riskier firms. Pricing is found to be more rational – less one day run‐up, less upward adjustment from offering range, and less likely to be overpriced in intermediate and longer terms.Originality/value – The paper demonstrates the importance of market s...
Algorithmic lattice kirigami: A route to pluripotent materials

We use a regular arrangement of kirigami elements to demonstrate an inverse design paradigm for folding a flat surface into complex target configurations. We first present a scheme using arrays of disclination defect pairs on the dual to the honeycomb lattice; by arranging these defect pairs properly with respect to each other and choosing an appropriate fold pattern a target stepped surface can be designed. We then present a more general method that specifies a fixed lattice of kirigami cuts to be performed on a flat sheet. This single pluripotent lattice of cuts permits a wide variety of target surfaces to be programmed into the sheet by varying the folding directions.
Reimbursement and Practice Policies Among Providers of Buprenorphine-Naloxone Treatment

ABSTRACT Background: Physician acceptance of cash payment and low adherence to practice guidelines may contribute to buprenorphine-naloxone diversion. The purpose of this study was to investigate the clinical practice policies of physicians who provide office-based treatment for opioid dependence with buprenorphine-naloxone. Methods: Data were obtained from 31 of 71 practices surveyed (response rate 43.7%) that provided answers to at least some of the survey questions. Results: Of these practices, 28 (90.3%) accepted cash as payment and 6 (19.4%) accepted only cash for treatment services. Analysis of open-ended responses to questions about office policies revealed wide variation among practices and overall suboptimal adherence to recommended treatment guidelines. Conclusions: These results underscore the need for continuing education for physicians who prescribe buprenorphine-naloxone.
Studying the Early Universe via Quark-Gluon Plasma

Abstract Shortly after the Big Bang, the early universe is a high temperature and high density environment. In order to recreate this state of matter in the laboratory, a little bang was created by colliding heavy ions at the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Laboratory and subsequently at the Large Hadron Collider (LHC) at CERN. From the most energetic collision at RHIC, the created temperature is estimated to be at least 221 MeV, where the quarks in the nucleon will no longer be confined and a new state of matter, quark-gluon plasma (QGP), is formed. Detailed studies of the QGP, reveal that QGP has the lowest “shear viscosity to entropy ratio” which is close to the lowest bound determined from quantum mechanics. This makes QGP the “most perfect fluid” in universe. The measured properties of QGP should also provide constraints for theoretical models of the early universe.
THE MEASUREMENT OF INTRAPULMONARY MIXING IN CHILDREN.

T K E A L V E O L A R GAS in a normal person breathing room air contains 80 per cent of nitrogen. Cournand 1 in 1941 showed that in normal adults breathing 100 per cent oxygen, the nitrogen present will be "washed out," so that after 7 minutes, less than 2 per cent of nitrogen remains in the alveolar air. In adults with chronic obstructive pulmonary disease, there are areas of lungs which are poorly ventilated, so that nitrogen is not removed as rapidly. In these patients more than 2 per cent of nitrogen remains after 7 minutes. This value reflects the nonuniformity of distribution of the inspired air and is called the "index of intrapulmonary mixing." Because 7 minutes is a relatively long interval for a young child to remain seated, concentrating, with a mouthpiece held tightly between his lips, it is not as satisfactory for use in pediatric respiratory disease as it is in adult medicine. Accordingly, a study was attempted to modify the method for use in children in a group ranging in age from 6 to 12 years. The data indicate that the pulmonary emptying rate is shorter in children than adults and that a 2 minute breathing interval is all that is required.
Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings

Ventricular arrhythmia originating from the outflow tract of the right ventricle is a presumed cause of late sudden death in patients after repair of tetralogy of Fallot. Exercise testing has been shown to enhance detection, and phenytoin has been shown to control ventricular arrhythmias in these patients. This study reports new findings in 3 patients who underwent electrophysiologic studies at postoperative cardiac catheterization; in each, sustained ventricular tachycardia was induced and found to originate from the inflow-septal area of the right ventricle. Using serial studies, the same sustained ventricular tachycardia was induced during therapeutic serum concentrations of phenytoin but not after propranolol. No patient had ventricular arrhythmia during a 24-hour electrocardiogram or during exercise. Although no patient had normal hemodynamic function, only 1 patient had right ventricular pressure greater than two-thirds systemic pressure. Each patient had undergone initial intracardiac repair at a relatively late age (3, 9, and 9 years).
Surface plasma resonances in free metal clusters

Les sections efficaces de photoabsorption de petits clusters du sodium neutre libre sont mesurees dans l'intervalle 452-604 nm. Les resultats indiquent que les spectres de photoabsorption sont domines par des oscillations du plasma de surface des electrons de valence. Les ordres experimentaux des mesures des sections efficaces de photoabsorption, au voisinnage des pics de resonance, sont compris entre 1 et 2 A 2 par electron delocalise
Naturalness, the autonomy of scales, and the 125 GeV Higgs

Abstract The recent discovery of the Higgs at 125 GeV by the ATLAS and CMS experiments at the LHC has put significant pressure on a principle which has guided much theorizing in high energy physics over the last 40 years, the principle of naturalness. In this paper, I provide an explication of the conceptual foundations and physical significance of the naturalness principle. I argue that the naturalness principle is well-grounded both empirically and in the theoretical structure of effective field theories, and that it was reasonable for physicists to endorse it. Its possible failure to be realized in nature, as suggested by recent LHC data, thus represents an empirical challenge to certain foundational aspects of our understanding of QFT. In particular, I argue that its failure would undermine one class of recent proposals which claim that QFT provides us with a picture of the world as being structured into quasi-autonomous physical domains.