cssi/SciSciGPT-SciSciNet huggingface dataset:
Discovering important people and objects for egocentric video summarization

We present a video summarization approach for egocentric or “wearable” camera data. Given hours of video, the proposed method produces a compact storyboard summary of the camera wearer's day. In contrast to traditional keyframe selection techniques, the resulting summary focuses on the most important objects and people with which the camera wearer interacts. To accomplish this, we develop region cues indicative of high-level saliency in egocentric video — such as the nearness to hands, gaze, and frequency of occurrence — and learn a regressor to predict the relative importance of any new region based on these cues. Using these predictions and a simple form of temporal event detection, our method selects frames for the storyboard that reflect the key object-driven happenings. Critically, the approach is neither camera-wearer-specific nor object-specific; that means the learned importance metric need not be trained for a given user or context, and it can predict the importance of objects and people that have never been seen previously. Our results with 17 hours of egocentric data show the method's promise relative to existing techniques for saliency and summarization.
Spin-Exchange-Relaxation-Free Magnetometry with Cs Vapor

We describe a Cs atomic magnetometer operating in the spin-exchange-relaxation-free (SERF) regime. With a vapor cell temperature of $103\text{ }\ifmmode^\circ\else\textdegree\fi{}\text{C}$ we achieve intrinsic magnetic resonance widths $\ensuremath{\Delta}B=17\text{ }\ensuremath{\mu}\text{G}$ corresponding to an electron spin-relaxation rate of $300\text{ }{\text{s}}^{\ensuremath{-}1}$ when the spin-exchange rate is ${\ensuremath{\Gamma}}_{\text{SE}}=14\text{ }000\text{ }{\text{s}}^{\ensuremath{-}1}$. We also observe an interesting narrowing effect due to diffusion. Signal-to-noise measurements yield a sensitivity of about $400\text{ }\text{pG}/\sqrt{\text{Hz}}$. Based on photon shot noise, we project a sensitivity of $40\text{ }\text{pG}/\sqrt{\text{Hz}}$. A theoretical optimization of the magnetometer indicates sensitivities on the order of $2\text{ }\text{pG}/\sqrt{\text{Hz}}$ should be achievable in a $1\text{ }{\text{cm}}^{3}$ volume. Because Cs has a higher saturated vapor pressure than other alkali metals, SERF magnetometers using Cs atoms are particularly attractive in applications requiring lower temperatures.
An emerging distributed work arrangement: an investigation of computer-based supplemental work at home

Recent advances in information technology and changes in social and economic relationships have led individual workers and organizations to explore various types of distributed work arrangements. This paper examines a specific type of distributed work arrangement, supplemental work at home. This arrangement refers to full-time employees doing job-related work at home in the evenings and on weekends. Based on a theoretical analysis of supplemental work, data gathered from a 346 computer-owners and 104 nonowners are empirically examined. The results suggest that the amount of time spent on supplemental work is positively related to work self-determination variables flexibility and control, portability of work tasks, the availability of a telecommunications link between the firm and the home, and household income, and negatively related to commuting time and the presence of children at home. The paper discusses the implications of supplemental work for organizational design and the employer-employee relationship, It concludes that compared to other types of work at home, supplemental work is one remote work arrangement that is likely to persist, especially for professionals and managers.
Studies on the Efficacy of Gastric Lavage as Practiced in a Large Metropolitan Hospital

AbstractThe efficacy of gastric lavage as it is practiced in a major metropolitan hospital was evaluated. From a population of 76 patients with chemical evidence of sedative-hypnotic drugs in the blood, two or more therapeutic doses were recovered from 15.8% of the lavage samples, and 10 or more therapeutic doses were recovered from 6.6%. In a population consisting of patients with detectable quantities of drugs in the lavage sample, diazepam and amitripty-line are more adequately recovered than the sedative-hypnotic drugs. Very poor recoveries were obtained in patients lavaged more than 2 h after ingestion except in cases of amitriptyline overdose or massive sedative-hypnotic ingestion. The study indicates that inadequate criteria are employed in selecting patients most likely to benefit from lavage. Dose, time since ingestion, and symptomatology are discussed as criteria for selection of patients for lavage.
The Political Consequences of Economic Dependence

This analysis attempts to examine the ability of one nation to induce other nations to follow lines of policy which they might otherwise not pursue, as a result of their economic dependence on the ...
Nature's genetic gradients and the clinical phenotype.

When God created the earth, he placed (modern) mankind in East Africa ≈200 000 years ago, as suggested by the phylogenetic and archeological studies.1,2 These hunter-gatherers populated the land and started to migrate, first to the west and southern tip of Africa and then north toward North Africa. Mankind gradually crossed the Arabian Peninsula to the Middle East and Eurasia. Then, over thousands of years of northerly movement, man crossed the Bering land bridge that connected Siberia to Alaska and migrated down to the Americas. This out-of-Africa migration took thousands of generations. It was interrupted by the Ice Age, which led to depopulation and isolation of the surviving population followed by the new waves of migrations, resulting in multiple founding populations.3 Articles see pages 552 and 558 At the genetic level, the tree of life was produced through replication of the genome. For the genome to replicate, cells are equipped with DNA polymerases to copy the parental DNA, which they do at blazing speeds.4 However, “no protein is perfect,” and neither are the DNA polymerases. So, the DNA polymerases commit occasional errors in copying the template (parental) DNA and incorporate wrong nucleotides into the new DNA strands. To correct the errors, nature afforded the cells with DNA repair enzymes, which are assigned the task of maintaining the integrity of the nucleotide pools before replication.5 Nevertheless, the process of DNA replication and editing, although exceedingly precise, is imperfect. The error rate of the DNA replication and editing machinery is estimated to be at 10−6 to 10−10 nucleotides incorporated into the new strand of DNA.6,7 The inheritance is forward. Therefore, the misincorporated nucleotides are passed on to the next generation, and with each generation, new errors in DNA replication are introduced. The occasional “errors of …
Before you slip into the night, you'll want something to drink: exploring the reasons for prepartying behavior among college student drinkers.

Prepartying among college students is an emerging topic of research and clinical focus. Unfortunately for some students, prepartying, or quick drinking before going out for the primary event of the evening, can lead to high blood alcohol levels, further drinking, and subsequent consequences. The present study was designed to explore the reasons for prepartying among a sample of 444 male and female students. Males and females reported arriving to a social event already under the influence, saving money, and making the night more interesting as their most highly endorsed reasons for prepartying. Males endorsed reasons relating to increased social and sexual facilitation with opposite sex peers to a greater extent than females. Although underage and legal drinking age participants did not differ in prepartying frequency or typical quantity, underage students reached higher estimated blood alcohol levels during prepartying. Finally, alcohol-related consequences were significantly and positively associated wit...
How should we measure the effect of ability grouping on student performance

In this volume, Betts and Shkolnik [Betts, J. R., & Shkolnik, J. L. (1999) The effects of ability grouping on student math achievement and resource allocation in secondary schools. Economics of Education Review, 19 , 1‐15] argue that studies that compare students in tracked versus untracked classes overestimate the impact of tracking on student achievement by not adequately controlling for student ability and motivation. In this paper we discuss the shortcomings of their analysis and reinterpret their results. The data used by Betts and Shkolnik do not allow one to accurately classify tracked and untracked classroom, since identification of heterogeneous classes is impossible. They compare abilitygrouped students in schools that report formally engaging in tracking to ability-grouped students in schools that track only informally. Our interpretation of their results suggests that there is little difference in student performance and resource allocation between schools that formally and informally group students by ability.[JEL I20] © 1999 Published by Elsevier Science Ltd. All rights reserved.
Imaginary Worldplay as an Indicator of Creative Giftedness

Creative potential in childhood, of a kind bearing fruit in maturity, reveals itself in imaginative play, the most complex of which is the invention of imaginary worlds (paracosms). Worldplay often includes the generation of stories, drawings, etc., that provide evidence of little c creative behavior. Historical examples (e.g., the Brontes) suggest that productive worldplay may thus serve as a “learning laboratory” for adult achievement. Early research explored ties between worldplay and later artistic endeavor. Recent study of gifted adults finds strong links, too, between worldplay and mature creative accomplishment in the sciences and social sciences. As many as 1 in 30 children may invent worlds in solitary, secret play that is hidden from ready view. Worldplay nevertheless figured tangentially in early studies of intellectual precocity. Improved understanding of the phenomenon, its nature and its potential for nurture, should bring childhood worldplay to the foreground as an indicator of creative giftedness.
Discordant regulatory changes in monocrotaline-induced megalocytosis of lung arterial endothelial and alveolar epithelial cells.

Monocrotaline (MCT) causes pulmonary hypertension in the rat by a mechanism characterized by megalocytosis (enlarged cells with enlarged endoplasmic reticulum and Golgi and a cell cycle arrest) of ...
Use of pilocarpine-induced alimentary secretions to measure intestinal shedding of Salmonella enteritidis in chickens.

SUMMARY. A technique has been developed that uses the parasympathomimetic drug pilocarpine to induce alimentary secretions in chickens for measuring local immune responses to Salmonella enteritidis strain SE6. A study was conducted to determine if these secretions could also be used to detect intestinal SE6 shedding. White leghorn chickens infected with 1 x 109 SE6 were sampled weekly using cloacal swabs, and the isolation rates from these samples were compared with alimentary secretions induced by oral administration of phosphate-buffered saline followed 45 minutes later with an intraperitoneal injection of 5% pilocarpine. At 9 days postinfection, isolation rates from the alimentary secretions were significantly higher than isolation rates from the swabs, and by day 16 they were double those from the swabs. In separate small experiments, alimentary secretions induced by pilocarpine alone also had significantly more SE6 isolations than did cloacal swabs on two of three sampling times examined. Direct culture of feces resulted in numerically but not significantly greater SE6 isolations than did cloacal swabs on two of three sampling times. These results indicate that induced intestinal material is a better sample source than cloacal swabs for detecting S. enteritidis intestinal infections in chickens and could have many applications in intestinal pathogenesis research.
Slovenian-American Literature: Louis Adamic’s Grandsons and Frank Mlakar’s HE, THE FATHER

The Slovenes in America, following the traditions of their native land, have a great enthusiasm for literature and depend on it as "the crucially important vehicle of their national consciousness and culture" explains Giles Edward Gobetz in the historical survey section of the Anthology of Slovenian American Literature (Willoughby Hills, Ohio: Slovenian Research Center of America, Inc., 1977). In addition to being the first anthology of Slovenian American literature, this is also one of the few collections.which makes no differentiation between work written in English and that written in the "home" language and translated. Adamic is probably the best known Slovenian American writer. He first won recognition with The Native's Return (1934), and he continued his success with many books contrasting the land of his birth and America. Some of these were My America (1938), From Many Lands (1940), My Native Land (1943), and A Nation of Nations (1945). His bibliographer, Henry Christian, has a list of 564 titles authored by Adamic and another 500 items dealing with him. During World War II Adamic was the editor and publisher of Common Ground, the first journal of multi-ethnic American literature. Frank Mlakar was born of immigrant parents in Cleveland. In the depths of the Depression he became a secretary to Adamic and later, assistant editor of Common Ground. He wrote poems, dramas, and short stories, but he is remembered for the brief triumph of his novel, HE, THE FATHER (Harper, 1950), a book that should be restored to print. 52
Organic–Inorganic Perovskites: Structural Versatility for Functional Materials Design

Although known since the late 19th century, organic–inorganic perovskites have recently received extraordinary research community attention because of their unique physical properties, which make them promising candidates for application in photovoltaic (PV) and related optoelectronic devices. This review will explore beyond the current focus on three-dimensional (3-D) lead(II) halide perovskites, to highlight the great chemical flexibility and outstanding potential of the broader class of 3-D and lower dimensional organic-based perovskite family for electronic, optical, and energy-based applications as well as fundamental research. The concept of a multifunctional organic–inorganic hybrid, in which the organic and inorganic structural components provide intentional, unique, and hopefully synergistic features to the compound, represents an important contemporary target.
Uptake of 131 by Rat Organs and Body Fluids Following Injection of Different I131 Preparations.

SummaryAn “extraneous” I131 component identical with component “S” of Ahn and Rosenberg or “U” of Taurog was isolated from cysteine-free radioiodide preparations (obtained from E. R. Squibb & Sons) by a chromatographic separation and elution procedure described earlier.One microcurie of NaI131 or of “extraneous” I131 were injected intraperitoneally into adult female rats. At the end of 1, 3 and 24 hours after injection, the animals were killed and the uptake of radioactivity in various organs and body fluids was measured. The results show that at one and 3 hours following injection, the uptake of NaI131 by stomach, thyroid, liver, intestine and plasma was significantly higher than the uptake of “extraneous” I131. However, during the same period, urinary excretion of both the compounds remained the same. At 24 hours following injection of either NaI131 or “extraneous” I131 there was a significant lowering of radioactivity in stomach, liver, intestine and plasma and there were no significant differences in ...
Intimate Partner Violence Among Same-Sex Couples in College: A Propensity Score Analysis

Intimate partner violence (IPV) is a pervasive social issue with numerous detrimental effects on individuals, families, and society. Existing research and a social-ecological minority stress framework suggest, as compared with mixed-sex couples, those in same-sex relationships may be at heightened risk for perpetrating and experiencing IPV. Using a U.S. sample of college students ( N = 4,081), this secondary data analysis contrasted the prevalence of five forms of IPV (i.e., physical, sexual, psychological, injury, any type) between those in mixed-sex ( n = 3,960) and those in same-sex ( n = 121) intimate partnerships. Comparative analyses were supplemented with propensity score weighting to help balance members of mixed-sex and same-sex relationships across eight potentially confounding variables (e.g., biological sex, age). Prior to the application of propensity score weighting, results suggested those in same-sex relationships are significantly more likely to perpetrate and/or experience IPV resulting in physical injury. Results from post-weighting analyses retained the significance and magnitude of model estimates. Taken together, results suggest, as compared with mixed-sex couples, U.S. college students in same-sex couples have greater odds of experiencing IPV perpetration and victimization resulting in physical injury, even after accounting for the influence of several potentially confounding variables. Findings support the utility and future application of propensity score analytic techniques in this type of research as well as the importance of recognizing the unique IPV risk and service needs of people in same-sex relationships.
Effects of repetitive low-pressure explosive blast on primary neurons and mixed cultures

Repetitive mild traumatic brain injury represents a considerable health concern, particularly for athletes and military personnel. For blast-induced brain injury, threshold shock-impulse levels required to induce such injuries and cumulative effects with single and/or multiple exposures are not well characterized. Currently, there is no established in vitro experimental model with blast pressure waves generated by live explosives. This study presents results of primary neurons and mixed cultures subjected to our unique in vitro indoor experimental platform that uses real military explosive charges to probe the effects of primary explosive blast at the cellular level. The effects of the blast on membrane permeability, generation of reactive oxygen species (ROS), uptake of sodium ions, intracellular calcium, and release of glutamate were probed 2 and 24 hr postblast. Significant changes in membrane permeability and sodium uptake among the sham, single-blast-injured, and triple-blast-injured samples were observed. A significant increase in ROS and glutamate release was observed for the triple-blast-injured samples compared with the sham. Changes in intracellular calcium were not significant. These results suggest that blast exposure disrupts the integrity of the plasma membrane, leading to the upset of ion homeostasis, formation of ROS, and glutamate release. Published 2016. †This article is a U.S. Government work and is in the public domain in the USA.
ACR Appropriateness Criteria® Prostate Cancer—Pretreatment Detection, Surveillance, and Staging

Despite the frequent statement that "most men die with prostate cancer, not of it," the reality is that prostate cancer is second only to lung cancer as a cause of death from malignancy in American men. The primary goal during baseline evaluation of prostate cancer is disease characterization, that is, establishing disease presence, extent (local and distant), and aggressiveness. Prostate cancer is usually diagnosed after the finding of a suspicious serum prostate-specific antigen level or digital rectal examination. Tissue diagnosis may be obtained by transrectal ultrasound-guided biopsy or MRI-targeted biopsy. The latter requires a preliminary multiparametric MRI, which has emerged as a powerful and relatively accurate tool for the local evaluation of prostate cancer over the last few decades. Bone scintigraphy and CT are primarily used to detect bone and nodal metastases in patients found to have intermediate- or high-risk disease at biopsy. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.
Tactile Sensing with Whiskers of Various Shapes: Determining the Three-Dimensional Location of Object Contact Based on Mechanical Signals at the Whisker Base.

Abstract Almost all mammals use their mystacial vibrissae (whiskers) as important tactile sensors. There are no sensors along the length of a whisker: all sensing is performed by mechanoreceptors at the whisker base. To use artificial whiskers as a sensing tool in robotics, it is essential to be able to determine the three-dimensional (3D) location at which a whisker has made contact with an object. With the assumption of quasistatic, frictionless, single-point contact, previous work demonstrated that the 3D contact point can be uniquely determined if all six components of force and moment are measured at the whisker base, but these measurements require a six-axis load cell. Here, we perform simulations to investigate the extent to which each of the 20 possible “triplet” combinations of the six mechanical signals at the whisker base uniquely determine 3D contact point location. We perform this analysis for four different whisker profiles (shapes): tapered with and without intrinsic curvature, and cylindri...
W-Band corrugated and non-corrugated conical horn antennas using Stereolithography 3D-printing technology

we are ideally looking for a cost-effective fabrication technique for any form structure light-weigh repeatable
Executive Functions Promote Well-Being: Outcomes and Mediators

The ability to control urges and impulses does more than keep us out of trouble. Over the long haul, people with strong executive functions do better in many areas of life, such as at school and in relationships. In the current chapter, we will review research that links executive functions to various facets of well-being including personal relationships, health, and academic achievement. We will explore why executive functions serve a protective role and will also consider whether enhancing executive functions has the potential to make us happier people.
Highly Elastic, Transparent, and Conductive 3D‐Printed Ionic Composite Hydrogels

Despite extensive progress to engineer hydrogels for a broad range of technologies, practical applications have remained elusive due to their (until recently) poor mechanical properties and lack of fabrication approaches, which constrain active structures to simple geometries. This study demonstrates a family of ionic composite hydrogels with excellent mechanical properties that can be rapidly 3D-printed at high resolution using commercial stereolithography technology. The new material design leverages the dynamic and reversible nature of ionic interactions present in the system with the reinforcement ability of nanoparticles. The composite hydrogels combine within a single platform tunable stiffness, toughness, extensibility, and resiliency behavior not reported previously in other engineered hydrogels. In addition to their excellent mechanical performance, the ionic composites exhibit fast gelling under near-UV exposure, remarkable conductivity, and fast osmotically driven actuation. The design of such ionic composites, which combine a range of tunable properties and can be readily 3D-printed into complex architectures, provides opportunities for a variety of practical applications such as artificial tissue, soft actuators, compliant conductors, and sensors for soft robotics.
Reading and writing in nursing education

Background and objective: Faculty identified the need for a gateway writing course (GWC) to prepare nurses for the writing requirements in the RN-to-BSN Completion (RNC) curriculum. This article describes the rationale for and development of a discipline-specific GWC developed for a RNC curriculum and reports research of student perspectives about the course and its effectiveness in preparing them to write in their nursing courses. Methods: The mixed method study included pre- and post-course surveys of self-efficacy in reading, writing, and research skills. Focus groups and interviews were used to identify readiness for and success in meeting curricular expectations for students who enrolled in the GWC and those who did not. Results: Statistically significant improvement occurred in all self-efficacy measures (reading: p ≤ .005, writing: p ≤ .01, accessing articles: p ≤ .005) from the beginning to the end of the GWC. Focus groups and interviews revealed five themes indicating improved readiness in students completing the GWC. Themes included perceptions of readiness, awareness, and preparedness for nursing courses; perceptions of confidence, mastery, efficiency, and self-sufficiency; enhanced knowledge of and ability to navigate academic processes and resourses; mastery of APA; and evidence of a reflective mindset and an evolving sense of professional identity. Conclusions: Students felt prepared for the RNC program after completing the GWC, and this sense of preparedness persisted throughout the program. The skills learned in the GWC allowed students to focus on understanding the professional concepts in nursing.
Truncated glioma-associated oncogene homolog 1 (tGLI1) mediates mesenchymal glioblastoma via transcriptional activation of CD44

The molecular pathways driving mesenchymal glioblastoma (GBM) are still not well understood. We report here that truncated glioma-associated oncogene homolog 1 (tGLI1) is a tumor-specific transcription factor that facilitates GBM growth, is enriched in the mesenchymal subtype of GBM and glioma stem cells (GSC), and promotes mesenchymal GSC by upregulating transcription of CD44. In an orthotopic GBM xenograft mouse model, tGLI1-overexpressing tumors grew more aggressively with increased proliferation and angiogenesis compared with control and GLI1-overexpressing xenografts. tGLI1 was highly expressed in GBM clinical specimens but undetectable in normal brains, whereas GLI1 was expressed in both tissues. A tGLI1 activation signature (tGAS) correlated with glioma grade, tumor angiogenesis, and poor overall survival, and GBMs with high tGAS were enriched with mesenchymal GBM/GSC gene signatures. Neurospheres contained increased levels of tGLI1, but not GLI1, compared with the monolayer culture; mesenchymal GSC expressed more tGLI1 than proneural GSC. Ectopic tGLI1 expression enhanced the ability of mesenchymal GSC to yield neurospheres in vitro and to form tumors in mouse brains. Selective tGLI1 knockdown reduced neurosphere formation of GBM cells. tGLI1 bound to and transactivated the promoter of the CD44 gene, a marker and mediator for mesenchymal GSC, leading to its expression. Collectively, these findings advance our understanding of GBM biology by establishing tGLI1 as a novel transcriptional activator of CD44 and a novel mediator of mesenchymal GBM and GSC.Significance: These findings highlight the role of a tumor-specific gain-of-function transcription factor tGLI1 in mesenchymal glioma stem cell maintenance and mesenchymal GBM growth. Cancer Res; 78(10); 2589-600. ©2018 AACR.
Linear time optimization for P 4-sparse graphs

Abstract Quite often, real-life applications suggest the study of graphs that feature some local density properties. In particular, graphs that are unlikely to have more than a few chordless paths of length three appear in a number of contexts. A graph G is P 4 -sparse if no set of five vertices in G induces more than one chordless path of length three. P 4 -sparse graphs generalize both the class of cographs and the class of P 4 -reducible graphs. It has been shown that P 4 -sparse graphs can be recognized in time linear in the size of the graph. The main contribution of this paper is to show that once the data structures returned by the recognition algorithm are in place, a number of NP-hard problems on general graphs can be solved in linear time for P 4 -sparse graphs. Specifically with an n -vertex P 4 -sparse graph as input the problems of finding a maximum size clique, maximum size stable set, a minimum coloring, a minimum covering by clique, and the size of the minimum fill-in can be solved in O( n ) time, independent of the number of edges in the graph.
X-Ray Structure of Poly-β-hydroxybutyrate

A detailed model for the crystal structure of poly-β-hydroxybutyrate (PHB) is proposed. The structure determination has been carried out by interpretation of X-ray diffraction photographs. The proposed PHB model accounts for polarized infrared dichroism and birefringence. It is a compact right-handed helix with a twofold screw axis along the chain. The unit cell is orthorhombic with a = 5.76 a, b = 13.20 a, c = 5.96 a (fiber axis). Two chain molecules pass through the cell parallel to the molecular axis and the derived space group, P212121 requires that they be of opposite polarity (“up” and “down”). This is in accord with the proven occurence of chain folding in the lamellar single crystals of the polymer. The coordinates (fractions of unit cell dimensions) x, y, z of four carbon and two oxygen atoms of one residue in the unit cell are:
Some algorithm design methods

Algorithm design may be denned as the task of finding an efficient data and control structure that implements a given input-output specification. This paper describes a methodology for control structure design, applicable to combinatorial algorithms involving search or minimization. The methodology includes an abstract process representation based on generators, constraints, mappings and orderings, and a set of plans and transformations by which to obtain an efficient algorithm. As an example, the derivation of a shortest-path algorithm is shown. The methods have been developed with automatic programming systems in mind, but should also be useful to human programmers.
Abstract LB-A07: Clinical utility of genomic assessment of blood-derived circulating tumor (ctDNA) in patients with colorectal cancers

Background: Genomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with colorectal cancers (CRC) were correlated with clinical characteristics and therapeutic outcomes. Methods: Plasma ctDNA testing (54-73 genes; all non-synonymous alterations are analyzed herein) was performed in 94 patients with CRC (PREDICT-UCSD; NCT02478931). Results: Ninety-six percent of patients had metastatic or recurrent disease at the time of blood draw. The median number of alterations/patient was 3 (range, 0-30). The most frequent alterations involved TP53 (52.1%), KRAS (34%), and APC (28.7%) genes; no two patients had identical molecular portfolios. Altogether, 74 patients (79%) had ≥ 1 alteration; 69 patients (93% of patients with ≥ 1 detectable ctDNA alteration) had ≥ 1 actionable alteration; 61 patients had an alteration actionable by an FDA-approved drug (on or off-label). Concordance between ctDNA and tissue genomics for the most frequent genes altered in ctDNA ranged from 63% to 86%, depending on the gene (median ~6 months between samples). Improved survival (multivariate) correlated with lung metastasis and with all ctDNA alteration fractions Conclusion: Most patients demonstrated potentially actionable ctDNA alterations. Improved outcomes were associated with lung metastases and low ctDNA percentage. Treatment with matched therapy correlated with significantly higher rates of SD ≥ 6 months/PR/CR (67% vs 27%). Dynamic changes in ctDNA were evident after anti-EGFR treatment, with emergence of resistance mutations, some of which may be druggable. Larger studies in CRC and other malignancies are ongoing. Citation Format: Maria C. Schwaederle, Shumei Kato, In Sil Choi, Paul T. Fanta, Lawrence Leichman, Scott Lippman, Razelle Kurzrock. Clinical utility of genomic assessment of blood-derived circulating tumor (ctDNA) in patients with colorectal cancers [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2017 Oct 26-30; Philadelphia, PA. Philadelphia (PA): AACR; Mol Cancer Ther 2018;17(1 Suppl):Abstract nr LB-A07.
IBD as a risk factor for prostate cancer: what is the link?

Chronic inflammation in the prostate is a suspected risk factor for prostate cancer. Burns and colleagues implicate chronic inflammation in prostate cancer development, albeit from an unexpected source — the gastrointestinal tract. This new study implicates a history of inflammatory bowel disease with an increased risk of a prostate cancer diagnosis.
CASEOUS CALCIFICATION OF THE MITRAL ANNULUS ASSOCIATED WITH EMBOLIC INFARCTS AND CHRONIC PERICARDIAL CALCIFICATION

Caseous calcification of the mitral annulus (CCMA) has been associated with embolic infarcts. While there are reports of caseous material fistulizing to the left atrium or ventricle, there is a paucity of literature with CCMA communicating to the pericardium. A 62 year old woman with chronic
Disjoint Subspaces for Common and Distinct Component Analysis: Application to Task FMRI Data

Data-driven methods based on independent component analysis (ICA) and its extensions, have been attractive for data fusion as they minimize the assumptions placed on the data. Two widely used extensions of ICA, joint ICA (jICA) and multiset canonical correlation analysis prior to joint ICA (MCCA-jICA) fuse data from different datasets by assuming identical mixing matrices. However, these methods typically only take the common features into account within the linked datasets by disregarding the available distinct features, thus limiting their usefulness. In this paper, we propose a new method for fusion based on ICA and canonical correlation analysis (CCA), disjoint subspace framework using ICA (DS-ICA), to identify and extract not only the common but also distinct features, to yield results that better reveal the underlying relationships between the datasets. Separate analyses on the common and distinct subspaces provide flexibility of choosing suitable algorithm and order for each subspace, ensuring more robust results than the competitive methods. We perform and demonstrate performance advantage of DS-ICA through both simulations and application to multiset functional magnetic resonance imaging (fMRI) data collected from healthy controls, as well as patients of schizophrenia performing an auditory odd ball task (AOD).
Development and analysis of eco-driving metrics for naturalistic instrumented vehicles

This article is concerned with the development of eco-driving metrics for instrumented vehicles in a longitudinal study environment. Motivations for developing such metrics include an ability to di...
UNDER-PRESCRIPTION OF SGLT2 INHIBITORS IN PATIENTS WITH DIABETES AND CARDIOVASCULAR DISEASE IN THE UNITED STATES

Diabetes is associated with increased risk of cardiovascular disease (CVD). Sodium-Glucose Transporter 2 inhibitors (SGLT2i) have been shown to reduce cardiovascular outcomes in patients with diabetes. We sought to describe SGLT2i prescription patterns in patients with diabetes and CVD in the United
Objective extraction of movement features prompting expert-identification of dystonia in ambulatory children with cerebral palsy

Abstract Aim To determine the specific movement features in children with cerebral palsy (CP) that prompt expert identification of dystonia Methods Dystonia identification in CP, particularly when co-morbid with spasticity, can be difficult. For this retrospective case-control study, we conducted a qualitative thematic analysis of consensus-building discussions between three pediatric movement disorders physicians as they attempted to identify the presence or absence of dystonia in gait videos of 40 subjects with spastic CP and periventricular leukomalacia. Results Initial unanimous consensus regarding the presence or absence of dystonia was achieved in 12 videos (30%). Following consensus building discussion, 22 additional videos (55%) yielded unanimous consensus. Two main themes were generated: 1) Unilateral leg or foot adduction that was variable over time, and 2) Difficulty in identifying dystonia. Codes contributing to Theme 1 were more likely to appear when a discussant was favoring the presence of dystonia in a video (Chi-square, p=0.004). Discussion These results provide specific movement features that could aid dystonia diagnosis in ambulatory children with CP. However, these results also suggest that, even amongst putative motor phenotyping experts, visual dystonia diagnosis in CP remains difficult, highlighting the need for developing and using objective dystonia diagnosis measures. What this paper adds -Dystonia identification is visually difficult, even for experts -Unilateral lower extremity variable adduction could represent gait dystonia in cerebral palsy -Qualitative thematic analysis objectively identifies expert-cited dystonia features in cerebral palsy
Albis Torres, una poeta con alas

espanolSe analiza la obra In Albis, que reune la produccion de la poeta cubana Albis Torres, escritora apenas publicada en su pais y mayormente omitida por la critica literaria. Se muestra el aporte de la autora a la generacion poetica de los anos ochenta, cuyos integrantes comienzan a escribir desde sus propias subjetividades, hasta el momento omitidas del panorama literario de la revolucion. Dentro de los espacios y sujetos aludidos y que se legitiman en esta decada resalta el discurso femenino, visiblemente presente en la escritura de Albis Torres, quien mediante diferentes imagenes referentes al acto de volar expresa su rechazo a aquellos emplazamientos que tratan de contenerla en un espacio condicionado y limitado por las reglas sociales, y en donde no puede desarrollarse plenamente como mujer o escritora. EnglishThe work analyzes In Albis, a collection of works by Cuban poet Albis Torres, a writer barely published in her country and largely overlooked by literary critics. The contribution of the author to the 1980’s poet generation is shown; the members of this generation started to write from their own subjectivities, thus far ignored by the revolution’s literary panorama. Within the alluded spaces and subjects, and which legitimated in this decade, the female discourse is stressed, visibly present in the wri-ting of Albis Torres, who by means of different images referring to flying expresses her refection on those locations that try to contain her in a space limited and conditioned by social rules and where she cannot fully develop as a woman or writer.
Influence of microscopic malignant peritoneal mesothelioma on posttreatment survival

e15534 Background: Progression of malignant peritoneal mesothelioma to clinically evident disease is poorly understood. Operative cytoreduction and post-operative intraperitoneal chemotherapy, foll...
Ribosome profiling elucidates the contribution of differential translation to differential gene expression in bundle sheath and mesophyll cells in maize

The efficiencies offered by C4 photosynthesis have motivated efforts to understand its biochemical, genetic and developmental basis. Reactions underlying C4 traits in most C4 plants are partitioned between two cell types, bundle sheath (BS) and mesophyll (M) cells. RNA-seq has been used to catalog differential gene expression in BS and M cells in maize and several other C4 species. However, the contribution of translational control to maintaining the distinct proteomes of BS and M cells has not been addressed. In this study, we used ribosome profiling (ribo-seq) and RNA-seq to describe translatomes, translational efficiencies, and microRNA abundance in BS and M-enriched fractions of maize seedling leaves. A conservative interpretation of our data revealed 39 genes exhibiting cell-type dependent differences in translational efficiency, fourteen of which encode proteins with core roles in C4 photosynthesis. Use of more relaxed criteria that are widely used in ribo-seq studies increased the set of differentially translated genes to several hundred. In addition, our data expand the set of genes known to be differentially expressed in BS and M cells, including genes encoding transcription factors and microRNAs. These data add to the resources for understanding the evolutionary and developmental basis of C4 photosynthesis and for its engineering into C3 crops.
Free-Living Ameba

Three genera of free-living amebae are known human pathogens that cause highly fatal central nervous system (CNS) infections in humans. These are Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri. Acanthamoeba spp. and Balamuthia mandrillaris both cause the highly fatal granulomatous amebic encephalitis (GAE). Naegleria fowleri, also commonly referred to as the brain-eating amoeba, causes primary amebic meningoencephalitis (PAM), which can infect any individual whether immunocompromised or not. Acanthamoeba spp. mostly infect immunocompromised patients, while cases of Balamuthia mandrillaris can infect any individual. Cases of PAM usually occur in children and young adults, and have a high fatality rate. A commonality between all CNS infections from FLA are their propensity to cause fulminant, highly fatal disease that often go undiagnosed or are only identified post-mortem.
Osteopetrosis in cattle

Osteopetrosis, a generalized defect of the skeletal system has been reported in U.S. and Canadian Angus calves more recently in Hereford calves, a Simmental calf in Kansas, a Simmental calf in Holland, and a Dutch Friesian calf in Holland. The pathology and genetic data of osteopetrosis in Angus and Hereford calves are reported here.
But Be Ye Doers of the Word: Moving beyond Performative Professional Development on Culturally Relevant Pedagogy

Educational organizations have expressed an interest in Cultural Relevant Pedagogy (CRP) as the guiding pedagogical framework. The increased interest in CRP is promising and raises questions and ch...
Student Projects Involving the Analysis of Web Sites of Extremist and Extremist-Affiliated Groups in the United States

This article discusses the benefits of using a technology-infused instructional module involving undergraduate students in a terrorism course reviewing U.S. extremist and extremist-affiliated Web sites. This assignment resulted in enhanced student academic achievement and improved technological proficiency. As such, the students who participated in this study will be able to apply their technological and analytical skills in future careers in the intelligence and law enforcement arenas.
The Elusive Inclusive: Black Food Geographies and Racialized Food Spaces

North American food scholars, activists and policymakers often consider how to make a community food project more inclusive to “vulnerable populations” to increase participation in local food efforts. Drawing from qualitative research conducted with two community food organizations in Seattle, Washington, I argue that inclusive efforts are not addressing the power asymmetries present in organizations and within communities. Engaging with black geographies literature, I reveal how a black food justice organization grapples with violent histories of slavery and dispossession rooted in a black farming imaginary, and works to re-envision this imaginary to one of power and transformation. The spatial imaginaries and spaces of each food organization acknowledge racial histories differentially, informing their activism. Black geographies possess knowledge and spatial politics that can revitalize community food movements, and I consider how white food activists might reframe their work so that their efforts are not fueling the displacement of residents of color.
Modeling and evaluation of d33 mode piezoelectric energy harvesters

A microfabricated d33 mode piezoelectric energy harvester (PEH) with unimorph cantilever structure patterned by interdigital electrodes was designed, fabricated and analyzed. New analytical expression for estimating output power was developed based on the modification of conformal mapping and Roundy's analytical modeling. The results using the new analytical equation can explain the effects of electrode design on the output power of d33 PEH. The output power increases with a longer finger width to a certain limit, and then decreases presumably due to depoling and polarization reversal by charge injection and charged defects in a piezoelectric layer.
An Antarctica-to-Spain HF ionospheric radio link: Sounding results

[1] Our research group in Electromagnetism and Communications is involved in a project dealing with the channel characterization of an ionospheric radio link from the Spanish Antarctic Base (62.6°S, 60.4°W) to the Observatori de l'Ebre (40.8°N, 0.5°E) in Spain. Since the link was established for the first time on December 2003, the sounder and measurement techniques have been improved on the basis of the preliminary results. In this paper, the final results of the project corresponding to the 2006/2007 sounding survey are presented. First the hardware and measurement techniques used to probe the channel are described. Then the results in terms of channel availability (and its daily, hourly, and frequency variation), multipath and Doppler spreads, and signal-to-noise ratio are discussed. These results are being used to design the physical layer of a low data rate transmission system intended to send the information acquired by a geomagnetic sensor in the Antarctica.
Analyzing Circuits with SPICE on Linux

Designing many of today's circuits would be impossible without the aid of SPICE--the Simulations Program with Integrated Circuit Emphasis
The Hull Remains of a Post Medieval Black Sea Merchantman from Kitten, Bulgaria

In the 1980s, the Bulgarian Centre for Underwater Archaeology, led by Dr Kalin Porozhanov, undertook limited work on a post medieval wreck lost off Cape Urdovize, near the town of Kitten. In 2000, the Institute of Nautical Archaeology and the Centre for Underwater Archaeology returned to excavate and record the shipwreck in detail. The largest and arguably most important artefact was the hull itself, as it is the first complete excavation of a Black Sea merchantman, dated to the late 18th or very early 19th century. This paper offers a complete and corrected description of the structure of the vessel.
Saccharomyces cerevisiae pneumonia in a patient with acquired immune deficiency syndrome.

The clinical course of a patient with a polymicrobial pneumonia that included Saccharomyces cerevisiae infection is described. S. cerevisiae was recovered from autopsy cultures of the lungs, spleen, oral mucosa, and small intestine, and organisms morphologically consistent with S. cerevisiae were visualized in histologic sections of the lung. The role of this organism as a human pathogen is reviewed. Images