cssi/SciSciGPT-SciSciNet huggingface dataset:
Label-Free and Non-invasive Biosensor Cellular Assays for Cell Adhesion

Cells rely on their matrix adhesion complexes to sense multiple environmental cues including extracellular matrix components, adhesive ligand density, surface rigidity and molecular and mechanical perturbations, thus governing their functions and behavior. Label-free and non-invasive biosensors offer generic, integrated, multi-parametric and kinetic measures of cell adhesion and its associated cellular processes. Various label-free biosensor cellular assays are reviewed, and their uses for cell adhesion are discussed.
Brain-derived neurotrophic factor increases expression of MnSOD in human circulating angiogenic cells.

Abstract Existing evidence suggests that brain-derived neurotrophic factor (BDNF) promotes survival and proliferation of endothelial cells, stimulates mobilization of hematopoietic progenitors, and induces angiogenesis in ischemic tissues. However, the mechanisms underlying vascular protective function of BDNF are poorly understood. We hypothesized that BDNF increases antioxidant capacity of circulating angiogenic cells. Human mononuclear cells were isolated from peripheral blood of 30 healthy male volunteers (48 ± 2 years old), and cultured in endothelial growth medium-2 for 4–5 days. The attached cells (so called early endothelial progenitor cells [early EPCs], or circulating angiogenic cells) expressed BDNF receptors, tropomyosin-related kinase B and p75 neurotrophin receptor. Treatment of early EPCs with recombinant human BDNF for 24 h significantly increased manganese superoxide dismutase (MnSOD) expression, but had no effect on expression of other antioxidant enzymes including copper zinc SOD (CuZnSOD), catalase, and glutathione peroxidase-1. BDNF stimulated phosphorylation of IκB kinase (IKK)α/β and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK); however it did not activate p38, Erk, or AKT. Treatment with nuclear factor κB inhibitor, PDTC, or JNK inhibitor, SP600125, attenuated BDNF-augmented MnSOD protein expression. BDNF treatment inhibited apoptosis induced by a superoxide anion generator LY83583, and serum starvation-induced cell detachment. These findings suggest that BDNF protects EPCs by increasing expression of MnSOD thereby enhancing their antioxidant capacity.
Glutamate and aspartate in cortical subarachnoid fluid in relation to convulsive activity

Abstract Glutamic and aspartic acids were measured in subarachnoid fluid taken from the surface of the cerebral cortex of the dog. This fluid is considered to be representative of the interstitial fluid under conditions allowing sufficient time for the attainment of diffusion equilibrium. Samples were taken prior to injection of a convulsant and at various stages in the development of convulsive activity induced by thiosemicarbazide, pentetrazole, picrotoxin and methionine sulfoximine. The levels of glutamate and aspartate showed no tendency to increase during either the latent period or the occurrence of convulsive activity. It therefore appears unlikely that the seizures induced by these convulsants result from leakage of glutamate or aspartate from damaged cells, or from failure of uptake mechanisms, with accumulation to excitatory levels in the interstitial fluid.
Redefining safety in commercial space: Understanding debates over the safety of private human spaceflight initiatives in the United States

Abstract In 2009 President Obama proposed a budget for the National Aeronautics and Space Administration (NASA) that canceled the Constellation program and included the development of commercial crew transportation systems into low Earth orbit. This significant move to shift human spaceflight into the private sector sparked political debate, but much of the discourse has focused on impacts to “safety.” Although no one disputes the importance of keeping astronauts safe, strategies for defining safety reveal contrasting visions for the space program and opposing values regarding the privatization of U.S. space exploration. In other words, the debate over commercial control has largely become encoded in arguments over safety. Specifically, proponents of using commercial options for transporting astronauts to the International Space Station (ISS) argue that commercial vehicles would be safe for astronauts, while proponents of NASA control argue that commercial vehicles would be unsafe, or at least not as safe as NASA vehicles. The cost of the spaceflight program, the technical requirements for designing a vehicle, the track record of the launch vehicle, and the experience of the launch provider are all incorporated into what defines safety in human spaceflight. This paper analyzes these contested criteria through conceptual lenses provided by fields of science and technology policy (STP) and science, technology, and society (STS). We ultimately contend that these differences in definition result not merely from ambiguous understandings of safety, but from intentional and strategic choices guided by normative positions on the commercialization of human spaceflight. The debate over safety is better considered a proxy debate for the partisan preferences embedded within the dispute over public or private spaceflight.
Right oesophageal bronchus associated with oesophageal atresia, tracheo-oesophageal fistula, tracheal stenosis, and left hypoplastic lung

We report a neonate with a rare communicating broncho-pulmonary foregut malformation associated with oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF). The malformation consisted of a right unilobed lung arising from a lower oesophageal bronchus, atresia of the right main tracheal bronchus with severe complete tracheal stenosis, hypoplastic left lung, high OA, and an unusual TOF. The malformation and association are both considered extremely rare, with only four similar cases previously reported. The anomaly was not correctable.
Lightweight and Informative Traffic Metrics for Data Center Monitoring

In recent years, thousands of commodity servers have been deployed in Internet data centers to run large scale Internet applications or cloud computing services. Given the sheer volume of data communications between servers and millions of end users, it becomes a daunting task to continuously monitor the availability, performance and security of data centers in real-time operational environments. In this paper, we propose and evaluate a lightweight and informative traffic metric, streaming frequency, for network monitoring in Internet data centers. The power-series based metric that is extracted from the aggregated IP traffic streams, not only carries temporal characteristics of data center servers, but also helps uncover traffic patterns of these servers. We show the convergence and reconstructability properties of this metric through theoretical proof and algorithm analysis. Using real data-sets collected from multiple data centers of a large Internet content provider, we demonstrate its applications in detecting unwanted traffic towards data center servers. To the best of our knowledge, this paper is the first to introduce a streaming metric with a unique reconstruction capability that could aid data center operators in network management and security monitoring.
Cse4p Is a Component of the Core Centromere of Saccharomyces cerevisiae

Histones are fundamental structural components of chromatin and are expected to play important roles in chromosome dynamics. Here, we present direct evidence that Cse4p, a histone H3 variant, is a structural component of the core centromere of S. cerevisiae. In histone H4 and Cse4p mutants, the core centromere chromatin structure is disrupted at restrictive temperature. Overexpression of Cse4p suppresses this defect in the H4 mutant, implying that the two proteins act together in centromere structure. We show by chromatin immunoprecipitation experiments that Cse4p is specifically cross-linked to centromeric DNA. Furthermore, by immunofluorescence microscopy, Cse4p is found in discrete foci consistent with that expected for centromeres. These results suggest the kinetochore is assembled on a specialized centromeric nucleosome containing Cse4p.
Anterior interbody arthrodesis with percutaneous posterior pedicle fixation for degenerative conditions of the lumbar spine

This is a retrospective case series to evaluate clinical variables, complications and outcome of 50 patients who underwent anterior lumbar interbody fusion (ALIF) supplemented with posterior percutaneous pedicle screw fixation for degenerative conditions of the lumbar spine. Twenty-four patients underwent single-level fusion and 26 patients had a two-level fusion for a total of 76 levels fused. The mean lengths of the anterior and posterior (including repositioning) portions of the procedure were 131 and 102 min, respectively. The mean estimated blood loss for the entire procedure was 288 ml. The overall adverse event rate was 12%. The mean VAS score for leg pain, VAS score for back pain and mean ODI all improved postoperatively. This study found that ALIF using allograft bone and rhBMP-2 combined with percutaneous pedicle screw fixation had a high fusion rate and a low incidence of perioperative complications. Patient outcomes showed significant improvements in back and leg pain and physical functioning.
Multisite stochastic weather generation using cluster analysis and k-nearest neighbor time series resampling

Abstract We offer a multisite stochastic weather generator which is an enhancement to the traditional K-nearest neighbor resampling approach. The proposed weather generator consists of three main components: (i) Clustering of spatial locations into homogeneous regions based on a selected attribute (precipitation), (ii) Markov transition probabilities (either on individual clusters or) over all eight wet/dry states of the three-cluster system to model the spatial precipitation occurrence, and (iii) the traditional K-NN weather generator applied to each cluster-averaged weather time series to generate weather sequences at all the desired locations. The weather generator is also adapted to conditional simulation based on seasonal forecasts involving modification of the third component. We demonstrate the utility of this approach by simulating daily weather sequences at 66 locations in the 25,000 sq. mile San Juan River watershed, a tributary of the Colorado River, USA. As the classic K-NN approach involves sampling from a domain-averaged feature vector, all daily weather is simulated across all locations simultaneously. While this preserves the joint statistics, it tends to be biased to the extremes on any given day. Our cluster-based approach offers the ability to account for regional persistence and spatial non-stationarities. In our comparison of the methods, the cluster-based approach demonstrates some improvement over the classic approach, particularly when modeling winter precipitation, reproducing spells, and in dry years. While this particular application shows only marginal improvement, we offer cluster-based resampling as a novel methodological contribution.
Optimizing Conditions for Experimental Oat Dehulling

ABSTRACT The determination of groat percentage in experimental oat breeding lines requires the dehulling of oats. Here, we report the results of our efforts to optimize dehulling conditions so that the most accurate and reliable result can be obtained. Hand dehulling was always reliable and accurate, however, it was the most time-consuming and tedious of the methods studied. Two mechanical methods of oat dehulling, compressed-air dehulling and impact dehulling, also frequently provided reliable results, however, results were strongly influenced by dehulling conditions. Optimal dehulling conditions represented compromises between unfavorable extremes. Correct aspiration strength was critical to accurate groat percentage determination. We have found that a secondary aspiration is highly desirable after compressed-air dehulling to remove hulls remaining with the groats after dehulling. Also, increased mechanical stress on oats as exerted either by the number of passes through the impact dehuller, or by the a...
Assessing Dissociative Symptoms and Dissociative Disorders in College Students in the Philippines

This study is part of a larger project (Gingrich, 2004) that examined dissociation in a student sample in the Philippines. High and low-moderate dissociators were identified from a sample of 459 freshman university students based on cutoff scores on two brief screening instruments. The Multidimensional Inventory of Dissociation (MID) and Structured Clinical Interview for DSM-IV Dissociative Disorders (SCID-D) were then used to determine if any of the participants met diagnostic criteria for dissociative identity disorder (DID) or other dissociative disorders (DDs). Comparisons were made between the frequency of specific DDs diagnosed by each instrument and an evaluation done of the usefulness of the MID and SCID-D as diagnostic tools in a Filipino student sample.
An apparatus for sampling density gradients

Abstract The device described facilitates removing viscous solutions used in certain density gradient separation procedures from plastic tubes. A previously described device was modified so that vacuum can be applied to the test tube connected to the base of the centrifuge tube. Thus suction can be applied to cause the flow of viscous solutions through the cannula inserted in the base of the plastic centrifuge tube. The outflow of solutions can be precisely controlled by regulating the rate at which air is admitted through a needle valve in the cap.
Effects of Broccoli Rotation on Lettuce Drop Caused by Sclerotinia minor and on the Population Density of Sclerotia in Soil

Field experiments were conducted at Spence Road site and at the Hartnell College East Campus site in Salinas, CA, to determine the effects of crop rotation with broccoli or a fallow period on lettuce drop caused by Sclerotinia minor and the density of pathogen sclerotia in the soil. Treatments at the Spence Road site with low inoculum density ( 7 sclerotia per 100 cm3 of soil) distributed uniformly included: continuous lettuce (LLLL), broccoli-lettuce-broccoli-lettuce (BLBL), broccoli-broccoli-lettuce-lettuce (BBLL), and fallow-lettuce-fallow-lettuce (FLFL). At the Spence Road site, continuous lettuce did not increase lettuce drop incidence for at least 2 years, although an increase in soilborne sclerotia was observed annually but was below the threshold at which a correlation between inoculum density and disease incidence is observed. Rotation with broccoli resulted in small reductions in disease incidence only in the first year. The density of sclerotia was lowest in the LFL treatment, and the highest in the LLL. At the Hartnell site, rotation with broccoli significantly reduced both sclerotia and lettuce drop incidence. The number of broccoli crops rather than the sequence of lettuce rotations with broccoli was critical for reducing the numbers of S. minor sclerotia in soil. Fallowing after a lettuce crop resulted in marginal reductions in sclerotia and lettuce drop incidence. Viability of recovered sclerotia was not significantly different between treatments, although differences between seasons were detected. Results suggest that rotations with broccoli can be a practical lettuce drop management strategy.
Choosing between Isocrates and Aristotle: Disciplinary Assumptions and Pedagogical Implications

This essay examines several disciplinary and pedagogical assumptions behind Aristotle's centrality in the classical rhetorical canon and calls for a reconsideration of the established hierarchical relation of Aristotle to Isocrates.
Bounded dataflow networks and latency-insensitive circuits

We present a theory for modular refinement of Synchronous Sequential Circuits (SSMs) using Bounded Dataflow Networks (BDNs). We provide a procedure for implementing any SSM into an LI-BDN, a special class of BDNs with some good compositional properties. We show that the Latency-Insensitive property of LI-BDNs is preserved under parallel and iterative composition of LI-BDNs. Our theory permits one to make arbitrary cuts in an SSM and turn each of the parts into LI-BDNs without affecting the overall functionality. We can further refine each constituent LI-BDN into another LI-BDN which may take different number of cycles to compute. If the constituent LI-BDN is refined correctly we guarantee that the overall behavior would be cycle-accurate with respect to the original SSM. Thus one can replace, say a 3-ported register file in an SSM by a one-ported register file without affecting the correctness of the SSM. We give several examples to show how our theory supports a generalization of previous techniques for Latency-Insensitive refinements of SSMs.
ACTIVATED ISOFORMS OF MMP-2 ARE INDUCED IN U87 HUMAN GLIOMA CELLS IN RESPONSE TO BETA -AMYLOID PEPTIDE

Prior studies using rat primary hippocampal cultures indicated induction of matrix metalloproteinases (MMPs) in response to beta-amyloid (A beta). Hence, it was of interest to determine whether MMP activity in a human cell line is influenced by A beta. A beta, but not interleukin-1beta (IL-1beta) or lipopolysaccharide (LPS), stimulated an active form of MMP-2 in human U87 glioblastoma cells, as well as increased the expression of the well-known activator of MMP-2, membrane-type (MT)-MMP. Activation experiments carried out with amino phenyl mercuric acetate (APMA), immunoprecipitation, as well as immunoblotting, suggest that the lower molecular weight, gelatin-degrading activity was an activated form of MMP-2. Furthermore, it was demonstrated that a synthetic furin convertase inhibitor, decanoyl-Arg-Val-Lys-Arg-chloromethylketone, decreased the production of A beta-induced active MMP-2 in U87 cells. The induction of MMP-3 by cytokines, but not by A beta, suggests that the effect of A beta on MMP-2 is selective. Although A beta stimulated tissue inhibitor of metalloproteinase-1 (TIMP-1), there was no obvious effect of A beta on TIMP-2 production in U87 cells. These results demonstrate that A beta induces an active form of MMP-2 likely by increasing the expression of MT-MMP in a human glioblastoma cell line. Active MMP-2 may degrade A beta or act on ECM components critical in neuronal survival mechanisms and possibly play a role in Alzheimer's disease (AD) neuropathology.
Association between parental nativity and autism spectrum disorder among US-born non-Hispanic white and Hispanic children, 2007 National Survey of Children's Health.

Abstract Background Limited studies suggest the prevalence of autism spectrum disorders (ASD) varies by whether maternal and child birth country are discordant. Objective/Hypothesis We explored associations between ASD and maternal and paternal nativity in a sample of US-born non-Hispanic white (NHW, n = 37,265) and US-born Hispanic (n = 4,690) children in the 2007 National Survey of Children’s Health (NSCH). Methods We assessed ASD prevalence within race-ethnicity and parental nativity subgroups. Prevalence ratios (aPR), comparing each group to NHW children with 2 US-born parents, were adjusted for child age, sex, and receipt of care in a medical home. Estimates were weighted to reflect US noninstitutionalized children. Standard errors were adjusted to account for the complex sample design. Results In NHW children with 2 US-born parents, ASD prevalence was 1.19%; estimates were similar for NHW children with a foreign-born mother or father. There was a striking heterogeneity between Hispanic children with 2 US-born versus 2 foreign-born parents (ASD prevalence 2.39% versus 0.31%, p = .05). Even after adjustment, PRs comparing ASD prevalence in Hispanic versus NHW children were vastly different for Hispanic subgroups, suggesting a substantially lower prevalence for Hispanic children with both parents foreign-born (aPR 0.2, 95% confidence interval 0.1-0.5) and a higher prevalence for Hispanic children with both parents US-born (aPR 2.0 [0.8-4.6]). Conclusions Previous studies comparing ASD prevalence between NHW and Hispanic children based on a composite Hispanic grouping without consideration of parental nativity likely missed important differences between these racial-ethnic groups. Continuing efforts toward improving early identification in Hispanic children are needed.
Comparative analysis of microarray normalization procedures

Motivation: An increasingly common application of gene expression profile data is the reverse engineering of cellular networks. However, common procedures to normalize expression profiles generated using the Affymetrix GeneChips technology were originally developed for a rather different purpose, namely the accurate measure of differential gene expression between two or more phenotypes. As a result, current evaluation strategies lack comprehensive metrics to assess the suitability of available normalization procedures for reverse engineering and, in general, for measuring correlation between the expression profiles of a gene pair. Results: We benchmark four commonly used normalization procedures (MAS5, RMA, GCRMA and Li-Wong) in the context of established algorithms for the reverse engineering of protein–protein and protein–DNA interactions. Replicate sample, randomized and human B-cell data sets are used as an input. Surprisingly, our study suggests that MAS5 provides the most faithful cellular network reconstruction. Furthermore, we identify a crucial step in GCRMA responsible for introducing severe artifacts in the data leading to a systematic overestimate of pairwise correlation. This has key implications not only for reverse engineering but also for other methods, such as hierarchical clustering, relying on accurate measurements of pairwise expression profile correlation. We propose an alternative implementation to eliminate such side effect. Contect: califano@c2b2.columbia.edu
Assessing the reliability of textbook data in syntax: Adger's Core Syntax

There has been a consistent pattern of criticism of the reliability of acceptability judgment data in syntax for at least 50 years (e.g., Hill 1961), culminating in several high-profile criticisms within the past ten years (Edelman & Christiansen 2003, Ferreira 2005, Wasow & Arnold 2005, Gibson & Fedorenko 2010, in press). The fundamental claim of these critics is that traditional acceptability judgment collection methods, which tend to be relatively informal compared to methods from experimental psychology, lead to an intolerably high number of false positive results. In this paper we empirically assess this claim by formally testing all 469 (unique, US-English)
Political geography: context and agency in a multiscalar framework:

I resisted the temptation to focus this essay around the topic of terrorism for two reasons. First, the review of the literature culminated in January 2003, and little substantive work with a geographic theme had appeared, with some exceptions (Booth and Dunne, 2002; Halliday, 2002; J.H. Johnson, 2002). Second, the political geography in print engaged themes that are crucial in understanding the developing geopolitical context and so deserve full consideration in their own right. However, The geographical dimensions of terror (Cutter et al., 2003), illustrates that political geographies of terrorism must compete with technological fixes and geo-surveillance for a place within the discipline.
A New Approach to the Rectilinear Steiner Tree Problem

We discuss a new approach to constructing the rectilinear Steiner tree (RST) of a given set of points in the plane, starting from a minimum spanning tree (MST). The main idea in our approach is to determine L-shaped layouts for the edges of the MST, so as to maximize the overlaps between the layouts, thus minimizing the cost (i.e., wire length) of the resulting RST. We describe a linear time algorithm for constructing a RST from a a MST, such that the RST is optimal under the restriction that the layout of each edge of the MST is an L-shape. The RST's produced by this algorithm have 8-33% lower cost than the MST, with the average cost improvement, over a large number of random point sets, being about 9%. The running time of the algorithm on an IBM 3090 processor is under 0.01 seconds for point sets with cardinality 10. We also discuss a property of RST's called stability under rerouting, and show how to stabilize the RST's derived from our approach. Stability is a desirable property in VLSI global routing applications.
Secure pseudo-random bit sequence generation using coupled linear congruential generators

Linear congruential generators (LCGs) of the form xi+1 = axi + b(mod m), have been used to generate pseudorandom numbers. However these generators have been known to be insecure. This implies that if a small sequence of numbers generated by an LCG is known then it is possible to predict the remaining numbers in the sequence that will be generated. We propose to generate a secure pseudorandom bit sequence by coupling two LCGs as follows. A 1 is output if the first LCG produces an output that is greater than the output of the second LCG and a 0 is output otherwise. The security of this sequence is shown by demonstrating the difficulty of obtaining the initial conditions of the two LCGs given the pseudorandom bit sequence output. If the modulus m is a power of 2 then efficient circuits can be designed for the proposed generators.
2-bit adder carry and sum logic circuits clocking at 19 GHz clock frequency in transferred substrate HBT technology

We report carry and sum circuits for a 2-bit adder. The 2-bit adders are designed to be part of a pipelined 2N-bit adder-accumulator. The ICs clock at a maximum of 19 GHz and were fabricated in InAlAs/InGaAs transferred substrate HBT technology. To obtain high clock rates in a design with multiple gate delays, we have employed a novel merged AND-OR logic structure using 4-level series-gated current-steering logic. Further, this logic is merged with the synchronizing latch circuit so as to minimize the overall gate delay. The 2-bit carry circuit has 250 transistors, a maximum clock frequency of 19 GHz, and dissipates 1.2 W. The sum logic circuit of a full adder was realized as a 4-level series-gated ECL XOR gate. This circuit has a maximum clocking frequency of 24 GHz, has 150 transistors and dissipates 750 mW.
Control of dynamic grasping systems using neural network approximation

A control algorithm for dynamic grasping systems using neural network approximation (NNA) is proposed. The kinematic and dynamic equations of the grasping system are derived. Based on these equations, a method for generalized computed torque control is developed. From computations of this control scheme, four elemental operation functions that are realized by elemental NNA functions are induced. All of the control computations in the grasping system are accomplished using neural network approximation. The PD control of a two-jointed finger mechanism is studied as an example of the application of the algorithm. Results using the NNA functions are compared. >
Uniparental Cytogamy: A Novel Method for Bringing Micronuclear Mutations of Tetrahymena into Homozygous Macronuclear Expression with Precocious Sexual Maturity

A new method of inducing self-fertilization, uniparental cytogamy, yields homozygous germinal and somatic genotypes in the ciliate Tetrahymena thermophila. Progeny are highly fertile and show a marked tendency for precocious sexual maturity. This method is highly effective in protocols designed to generate and express nonlethal dominant or recessive mutations.
Peer First Impressions of Childhood Maltreatment Victims

ABSTRACTThe impact of childhood maltreatment effects can extend beyond the immediate stress of abusive family environments. College students (N = 435) exposed to childhood domestic violence or parental physical abuse were expected to be viewed less favorably by their peers than their nonabused counterparts. They were expected as well to be less accurate in predicting the first impressions left on their peers after 25-minute unstructured interactions. Partial support was found for both hypotheses. Relatively harsher (d = .49) peer first impressions were found among domestic violence witnesses. Domestic violence (d = .58) and parental physical abuse (d = .49) victims overestimated peer ratings. Social anxiety during peer interactions was higher among women exposed to either form of childhood maltreatment. Men from violent families viewed themselves less favorably than their peers (r = .22, p < .05). These results further implicate childhood maltreatment as a contributing factor in peer distancing and rejection.
Unstructured Nonlinear Free Surface Flow Solutions: Validation and Verification

A nonlinear free surface solution methodology is incorporated within an existing three-dimensional, unstructured Navier-Stokes solver, . This portable, parallel solver uses a node-based finite volume method to solve the incompressible Reynolds-averaged NavierStokes equations on mixed element high-aspect ratio grids, includes several turbulence models to simulate the affects of turbulence within the boundary layer, and has the capability to simulate flow through rotating propellers accurately. To obtain a nonlinear free surface, the kinematic free surface equation is solved at each time level via a finite element implementation, valid on both triangles and quadrilaterals; after several time steps (approximately 200), the grid is moved to match the free surface elevations while conforming to the geometry. Robust grid movement is achieved by using a three-dimensional extension of Farhat’s torsional spring analogy. Validation studies include a grid refinement for the free surface on a circle based on a prescribed velocity field, and of flow around a submerged NACA0012 hydrofoil. For the NACA0012 hydrofoil, for the viscous and inviscid Wigley hull and for the DTMB Model 5415 series hull, wave profiles along the hull are compared against available experimental results as well as numerical results from a more mature structured nonlinear free surface code UNCLE.
Systemische corticosteroïden bij acute rhinosinusitis

Vraagstelling Rhinosinusitis – vaak gekenmerkt door rinorroe, verstopte neus en aangezichtspijn – is een veelvoorkomende klacht in de huisartsenpraktijk.
Apparent Magnesium Absorption and Retention and Serum Mineral Concentrations in Lambs Fed Different Sources of Magnesium1,2

This study was conducted to determine apparent Mg absorption and retention and serum mineral concentrations in lambs fed diets containing different dietary sources of Mg. Rambouillet wether lambs (n = 20; 39 ± 0.6 kg) were weighed, bled via jugular puncture, randomized to dietary treatments, and housed in metabolism crates for a 7-d adaptation period followed by 5 d of total urine and fecal collection. Lambs were offered 908 g/d of a basal cottonseed hull, corn-based diet with no supplemental Mg source (control) or the basal diet with MgO, weathered Mg-mica (WMM), or unweathered Mg-mica (UMM) to provide 0.1% of supplemental dietary Mg. Digestibilities of DM, OM, and NDF, as well as serum concentrations of Mg, Ca, Cu, and Zn, did not differ (P>0.10) among diets. Similarly, apparent N absorption and retention (g/d and intake percentage) did not differ (P>0.10) among diets. Apparent Mg absorption (%) by lambs fed MgO and the control (X¯=33.56%) was 52% higher (P<0.05) than that by lambs fed WMM (22.05%), and apparent Mg absorption (%) by lambs fed WMM was 4.24 × greater (P<0.05) than that by lambs fed UMM (5.20%). Lambs fed UMM had lower K and Fe retention (intake percentage) than lambs fed the other diets. Based on these results, MgO seems to be a more available Mg source than the two other sources evaluated, and UMM seems to have negative impacts on Mg, K, and Fe utilization.
Gadolinium toxicity: Iron and ferroportin as central targets

Gadolinium-based magnetic resonance (MR) contrast agents (GBCM) causes a devastating systemic fibrosing illness, nephrogenic systemic fibrosis (NSF), in patients with reduced kidney function. GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxicity and NSF. GBCA might similarly target iron-rich, ferroportin-expressing structures such as globus pallidus and cerebellar dentate nucleus in the brain to result in metal accumulation and potential toxicity.
Woven Wonders and Saving Basketry at the Arizona State Museum

Advances in conservation employed at the Arizona State Museum have expanded the research options for over 35,000 ethnographic and archaeological perishable objects since 2012. The Woven Wonders basketry conservation project has provided increased access to the collection, instituted new conservation treatment technique, initiated new research topics, provided advanced educational opportunities, instigated new forms of collaborative conservation, and reduced material loss from items in the collection. The Woven Wonders project was funded with a Save America's Treasure grant, two Institute of Museum and Library Services grants, one Preservation Training Grant, two Kress Foundation grants, and numerous private donations. The project has resulted in a state-of-the-art visible storage vault with an adjacent interpretive gallery that is home to the Woven Through Time: American Treasures of Native Basketry and Fiber Art.
Decentralization as a Post-Conflict Stabilization Tool: The Case of Sierra Leone

Summary Sierra Leone's experience with decentralization as a post-conflict stabilization tool highlights both the value of making and keeping a promise to empower citizens through local government and the importance of fully implementing that promise over a longer time horizon. The emergence of the country from civil conflict into peace and stability is one of the greatest success stories of post-conflict stabilization. Although the nation has enjoyed over a decade of peace (and peaceful transitions from party to party), many of the conditions that laid the groundwork for conflict remain, especially in rural areas, due to the partial implementation of the decentralization framework. Based on a post-conflict perspective, we review the re-emergence of local governments in Sierra Leone following the civil war, the institutional and legal framework within which they exist, and some of the remaining challenges the nation faces. Copyright © 2016 John Wiley & Sons, Ltd.
Plerixafor (P) plus G-CSF (G) in previous peripheral blood progenitor cell (HPC) mobilization failures (MF)

7095 Background: Successful autologous stem cell transplantation (AT) requires harvesting sufficient HPC to ensure reliable engraftment, which cannot be accomplished in ∼10% of previously treated p...
Understanding the drivers of interprofessional collaborative practice among HIV primary care providers and case managers in HIV care programmes

Care coordination programmes are an important aspect of HIV management whose success depends largely on HIV primary care provider (PCP) and case manager collaboration. Factors influencing collaboration among HIV PCPs and case managers remain to be studied. The study objective was to test an existing theoretical model of interprofessional collaborative practice and determine which factors play the most important role in facilitating collaboration. A self-administered, anonymous mail survey was sent to HIV PCPs and case managers in New York City. An adapted survey instrument elicited information on demographic, contextual, and perceived social exchange (trustworthiness, role specification, and relationship initiation) characteristics. The dependent variable, perceived interprofessional practice, was constructed from a validated scale. A sequential block wise regression model specifying variable entry order examined the relative importance of each group of factors and of individual variables. The analysis showed that social exchange factors were the dominant drivers of collaboration. Relationship initiation was the most important predictor of interprofessional collaboration. Additional influential factors included organisational leadership support of collaboration, practice settings, and frequency of interprofessional meetings. Addressing factors influencing collaboration among providers will help public health programmes optimally design their structural, hiring, and training strategies to foster effective social exchanges and promote collaborative working relationships.
Avalanche breakdown enhancement by mesa contouring

In a thyristor there are two junctions that have to support high breakdown voltages. One supports the maximum forward-blocking potential and the other supports the reverse-blocking potential. For an idealized case in which the device shows perfect symmetry and has an almost perfect cathode-emitter short, the two blocking potentials are equal. In real-life devices this is rather an exceptional situation because the avalanche breakdown is limited by surface rather than by bulk breakdown and the two junctions have different edge contours. The reverse-blocking junction is usually beveled with a positive angle, whereas the forward-blocking junction is beveled, for practical reasons, with a negative angle. It is of interest to fully utilize the material’s properties and to obtain full breakdown symmetry, with the bulk breakdown as the final limit.
Whiteness and Serendipity

The current focus on Whiteness is timely, as the papers included in the Major Contribution extend the discourse first presented by The Counseling Psychologist in 1993. The articles explore the evol...
Trust Me, I’m an Expert: Scientific and Legal Expertise in Scalia’s Jurisprudence

An enduring theme of conservative thought is mistrust towards claims of special expertise, grounded in technical knowledge and methods, as applied to policy, politics, and the organization of human affairs. Justice Scalia’s judicial opinions on education as well as in other areas reflect this stance, especially as applied to behavioral sciences and the law itself. Like science, the law is entrusted to an elite cadre of experts armed with specialized knowledge and training. Those experts purport to rely on determinate, neutral, objective principles in making decisions affecting society as a whole. Scalia is wary of this depiction of the law and its potential misuse, especially for questions of governance and social regulation. For Scalia, the exercise of legal and scientific expertise masks partisan preferences. Claims of specialized knowledge, both legal and scientific, enable a small, unrepresentative elite of government officials and judges to impose a progressive cultural and policy agenda on the nation as a whole. Too often these operate in derogation of democratically enacted rules and the traditional understandings and practices favored by ordinary people.
26-Week Fibroid Uterus, Hydroureter, Hydronephrosis, and Infertility

A 35-year-old patient with massive 26-week fibroid uterus, mild pressure symptoms, back pain, hydroureter, and hydronephrosis. The patient has been trying to conceive × 8 months. She also describes heavy menstrual bleeding, changing pads every hour for 3 days per month.
Der ›Danae Klage‹ des Simonides und Nietzsches Grundlagen der Textkritik

Als er sich von einer wahrend seines Militardienstes im Fruhjahr 1868 erlittenen Verletzung erholte, schrieb Nietzsche seinem Berater Friedrich Ritschl in Leipzig und informierte ihn daruber, dass er an einigen Verbesserungen zu Simonides Danae Klage gearbeitet hatte und dem Rheinischen Museum bald einen Aufsatz einreichen wolle. In dem Brief verwies er mit einer idiosynkratischen Phrase auf seine Emendationen, deren Bedeutung den Gelehrten bislang entgangen sei. Er erzahlte Ritschl, dass Simonides Gedicht seit seiner Schulzeit als unvergesslich in seinem Kopf haften geblieben sei (›wie eine unvergesliche Melodie im Kopfe gelegen‹) und er deshalb hoffte, dass Ritschl »nicht gar diesmal auch eine ›lyrische‹ Conjektur in seinem Hefte entdecken wurde«. Der zum Ausdruck gebrachte Wunsch, dass Ritschl in seinem Heft keine Emendierung von lyrischer Art fande sowie die Benutzung des Begriffs ›lyrische Konjektur‹ fuhren zu der Annahme, dass er nicht einfach Verbesserungen zu einem lyrischen Gedicht meinte, sondern auch Korrekturen, die von einem Lyriker vorgeschlagen wurden. Dieser Beitrag stellt die Behauptung auf, dass der Begriff ›lyrische Konjektur‹ einerseits eine Art lyrischer Verfassung und andererseits eine Textkritik meint. Als solche gibt dieser Begriff uns Auskunft uber das wechselseitige Verhaltnis zwischen den textphilologischen Verfahren Nietzsches und die Weise, wie er seine eigenen Schriften verfasste.
Time-invariant PT product and phase locking in PT -symmetric lattice models

Over the past decade, non-Hermitian, $\mathcal{PT}$-symmetric Hamiltonians have been investigated as candidates for both a fundamental, unitary, quantum theory and open systems with a nonunitary time evolution. In this paper, we investigate the implications of the former approach in the context of the latter. Motivated by the invariance of the $\mathcal{PT}$ (inner) product under time evolution, we discuss the dynamics of wave-function phases in a wide range of $\mathcal{PT}$-symmetric lattice models. In particular, we numerically show that, starting with a random initial state, a universal, gain-site location dependent locking between wave-function phases at adjacent sites occurs in the $\mathcal{PT}$-symmetry-broken region. Our results pave the way towards understanding the physically observable implications of time invariants in the nonunitary dynamics produced by $\mathcal{PT}$-symmetric Hamiltonians.
PHYSICAL THERAPY INTERVENTION FOR A PATIENT WITH POST-SURGICAL SHOULDER CAPSULORRHAPHY

Background: Posterior shoulder capsulorrhaphy is a surgical procedure to help restore shoulder joint stability in patients with a history of recurrent shoulder dislocations. Physical therapy (PT) may be beneficial in outpatient rehabilitation to improve patient shoulder range of motion (ROM), muscular strength, endurance, joint stability, and return to prior level of activities after general shoulder surgery. The purpose of this case study was to describe PT intervention for a patient with shoulder posterior capsulorrhaphy in an outpatient setting. Methods: 21-year-old male with post-surgical right shoulder posterior capsulorrhaphy due to multiple posteriorshoulder dislocation. Patient’s impairments were right shoulder weakness, decreased ROM, and functional immobility due to pain and a retracted capsule. PT intervention was 2-3X per week for nine weeks and included therapeutic exercises, manual therapy, modalities, and patient education for a home exercise program (HEP). Results: Patient was seen for 13 visits in an outpatient PT setting which improved his shoulder active ROM, strength, and outcome measures. The pain was also reduced. He returned to work with light duty restrictions after the 3rd week of PT and was able to perform normal responsibilities by the 9th week. He achieved the majority of his goals. Conclusion: PT intervention may have accelerated the progression of patient’s functional mobility, strength, ROM, and reduction of pain. Compared to the currently available literature for this diagnosis, the patient returned to normal function three weeks earlier than normal, probably due to earlier internal rotation exercise. Future research should include a randomized control trial regarding effective PT interventions following shoulder capsulorrhaphy surgery.
The Role of Oral Language in the Evolution of Manual Language

An examination of various French and English documents of the 18th and 19th century, especially reports, articles and books written by instructors of the deaf in Europe and the U.S. throws light on the conditions under which and the ways in which manual language evolved over the last two hundred years. This inquiry has revealed the following: (1) Manual languages in the U.S., France, and Italy (among other countries) have been subject to systematic efforts at annihilation by the dominant (oral) language group. (2) In this, they are like other minority languages such as Basque, Catalan, Canadian French, etc. (3) Efforts at annihilation take two forms — dialectizing a language (Provencal in France) or outright replacement (American Indian Languages in the U.S.). With regard to manual communication in the U.S., the former approach is called “Signed English”, the latter “oralism”. (4) Both ways of annihilating sign have been attempted in the 18th and 19th centuries, generally in alternation, using the schools as a vehicle, and with little lasting effect. (5) Intrusions from oral language that remain in ASL can often be detected because of their lack of pictorial roots. It is hypothesized that all formational, morphological and syntactic processes in ASL that do not have a pictorial basis are either the result of extrinsic oral language forces or the intrinsic evolution from iconicity to encodedness.
Impunity for Political Killing in a Comparative Perspective

In this chapter, I examine the relationship between electoral competition in the 1990s and the (un)rule of law for political killings in Mexico and other democratizing nations. Electoral competition in Mexico in the 1990s between the PRI and the PRD occurred across multiple municipalities within different states in the 1989–2000 period but PRD leaders and members were not all killed equally in every municipality or in every state. To demonstrate it was the degree and level of threat posed by the PRD as a political party (not the rural origins of its members per se) which explains the targeting of perredistas for political assassination in the municipalities where they were killed, I begin the chapter with an analysis of quantitative data on Mexican municipalities.
Modelling Variability in Hot-Star Winds

I review 2-D hydrodynamical simulations of rotating hot-star winds with azimuthal structure induced by modulation of the radiative driving force near the wind base. As a first step toward examining more realistic perturbation mechanisms (e.g., nonradial pulsations, or magnetic fields), the driving modulation here is taken to arise from bright and dark spots in the stellar photosphere. These spots induce decreases or increases in wind flow speed, and as the star rotates, spiral “Co-Rotating Interaction Regions” (CIRs) form, much as in the solar wind, from interaction between fast and slow flow streams. A new feature unique to line-driven flow is a velocity-gradient kink that propagates inward from interaction fronts at a fast radiative-acoustic mode speed. The slowly evolving velocity plateaus that form behind such kinks give rise to absorption features with a slow apparent acceleration, much like the Discrete Absorption Components (DACs) often observed in UV wind lines from hot stars. In simulation models with base driving sinusoidally modulated between increase and decrease, there arise alternating spiral streams of enhanced or decreased density, associated respectively with decreased or increased flow speeds. These speed variations have substantial impact on the line profile, and so these dynamical simulation are not as successful as analogous kinematic models of corotating density streams in reproducing the “phase-bowing” of periodic absorption modulations observed in the recent IUE ‘Mega’ project.