cssi/SciSciGPT-SciSciNet huggingface dataset:
Fear of the Queer Child

This article is about the fear of the queer child — the fear that exposing children to homosexuality and gender variance makes them more likely to develop homosexual desires, engage in homosexual acts, deviate from traditional gender norms, or identify as lesbian, gay, bisexual, or transgender. This fear is thousands of years old, but it has undergone a remarkable transformation in the last half-century, in response to the rise of the LGBT movement. For centuries, the fear had been articulated specifically in sexual terms, as a belief that children would be seduced into queerness by adults. Since the 1970s, it has been reformulated in the more palatable and plausible terms of indoctrination, role modeling, and public approval.Since the earliest days of the LGBT movement, advocates have responded to this fear by insisting that it is empirically false — that sodomy laws have “nothing to do” with children, that marriage laws have “nothing to do” with schools, that children raised by lesbian and gay parents are “no different” than children raised by heterosexual parents — and above all, that children’s sexual orientation and gender identity are fixed early in life and cannot be learned or taught, chosen or changed. In recent years, this empirical strategy has begun to falter, as advocates run up against the inherent vagueness, incompleteness, and unpredictability of empirical data. To break through this strategic impasse, this article highlights a growing vanguard of scholars, lawyers, and judges who are developing a normative challenge to the fear of the queer child. It argues that the state has no legitimate interest in encouraging children to be straight or discouraging them from being queer, because it may not presume that queerness is immoral, harmful, or inferior — in children or in anyone else. The state must adopt a neutral stance toward children’s straightness or queerness, without attempting to promote one set of desires, behaviors, or identities over the other.
Decoupled Representation of the Error and Trajectory Estimates for Ef_cient Pose Estimation

In this paper we present a novel approach for the parameterization of the trajectory of a moving platform, which facilitates the development of real-time pose-estimation methods. The key idea of the proposed approach is the decoupling of the parameterization of the trajectory estimate from the parameterization of the error in this estimate. Specifically, we represent the trajectory estimate as usual, via a set of pose states, each associated with a sensor reading (e.g., a laser scan or an image). The novelty of our approach lies in the representation of the estimation errors, for which we employ B-splines. This decoupled formulation, which we term Decoupled Estimate-Error Parameterization (DEEP) offers two key advantages. First, the use of a pose-based representation of the trajectory allows us to represent arbitrarily complex trajectories. Second, the use of B-splines for error representation allows us to control the computational complexity of an estimator, by selecting the density of the knots of the B-spline. We empirically demonstrate that, in the problem of visual-inertial localization, the DEEP formulation leads to substantial computational gains, while incurring only a small loss of estimation performance.
Planning under uncertainty for dynamic collision avoidance

We approach dynamic collision avoidance problem from the perspective of designing collision avoidance systems for unmanned aerial vehicles. Before unmanned aircraft can fly safely in civil airspace, robust airborne collision avoidance systems must be developed. Instead of hand-crafting a collision avoidance algorithm for every combination of sensor and aircraft configurations, we investigate automatic generation of collision avoidance algorithms given models of aircraft dynamics, sensor performance, and intruder behavior. We first formulate the problem within the Partially Observable Markov Decision Process (POMDP) framework, and use generic MDP/POMDP solvers offline to compute vertical-only avoidance strategies that optimize a cost function to balance flight-plan deviation with risk of collision. We then describe a second framework that performs online planning and allows for 3-D escape maneuvers by starting with possibly dangerous initial flight plans and improving them iteratively. Experimental results with four different sensor modalities and a parametric aircraft performance model demonstrate the suitability of both approaches. (Copies available exclusively from MIT Libraries, Rm. 14-0551, Cambridge, MA 02139-4307. Ph. 617-253-5668; Fax 617-253-1690.)
The heel of achilles: calcaneal avulsion fracture from a gunshot wound.

Greek mythology relates that the legendary warrior Achilles was made invincible by his mother Thetis, who dipped him in the River Styx while holding him by his heel. Because his heel was never imme...
Gaseous diffusion in a stressed-thermoelastic solid. Part I: The thermomechanical formulation

A phenomenological theory is proposed for the diffusion of a dilute solution of a gas in a thermoelastic solid. It is assumed that the thermomechanical behavior of the solid is unaffected by the presence of the gas. On the other hand the presence of the solid is recognized by the gas by letting certain thermomechanical variables of the solid to enter into the constitutive equations of the gas. The constitutive functionals of the gas are restricted by the principles of continuum physics. These principles are currently referred to as equipresence, material objectivity, entropy production inequality, as well as the balance equations of mass, linear and angular momentum and internal energy. By this approach, axiomatic statements on the existence of equations of state are avoided and the classical results of linear irreversible thermodynamics are obtained by further specialization of the proposed theory.
Determinants of Japan's Business Success: Some Japanese Executives' Views

In the trans-Pacific debate between Japan and the United States which seems to heat up periodically opinions on the reasons for Japan's economic and business success differ substantially among both American and Japanese executives. As the yen rises and the dollar falls, or as the Japanese favorable balance of trade vis-a-vis the United States reaches a new high for 1986 it was $58 billion emotions can run high. Depending on the industry affected, or the particular company involved, accusations of "Japan bashing," "unfair competition," "hidden tariffs," or "lack of understanding of Japanese ways," to name only a few, are made. To help shed light on these issues, a survey of how Japanese executives view their country's success was carried out in Japan in the spring of 1985. While a larger sample of Japanese executives (representing organizations in motor vehicle manufacturing, computer manufacturing, trade, the business federation, government, and academia) were interviewed about their opinions, this article reports only on the contrast between the official and unofficial viewpoints. As might be expected, representatives of government and the main business federation tended to take the official view, while others shared their personal perceptions with the author. It is of some importance that these contrasting viewpoints be known to help keep open the channels of communication between managers and policymakers on both sides of the Pacific.
The Effects of Microstructures on Normal and Early Failures of Interconnects Caused by Electromigration

Microstructure plays a key role in reliability of interconnects. However, a quantitative correlation between microstructure and reliability of interconnects is lacking. This paper develops a statistical description of effective diffusivity of interconnects by considering grain boundaries, bulk lattice and line interface diffusion, and introduces a microstructure-based electromigration lifetime prediction model for normal failures of interconnects. Further, the probability of early failure of interconnects due to a severe microstructural inhomogeneity is calculated. Using the sub-population failure model, the mean time to failure of interconnects, with a range of microstructures from polycrystalline to hyper-bamboo, are simulated. The reported increase in lifetimes of wide polycrystalline lines with increasing w/d is mainly ascribed to reservoir effects of bonding pads in test structures. Reported lifetime prediction model may be used as guidance for circuit design and accelerated testing.
Confronting measured near- and sub-barrier fusion cross sections for 20 O+ 12 C with a microscopic method

Recently measured fusion cross sections for the neutron-rich system ${}^{20}$O+${}^{12}$C are compared to dynamic, microscopic calculations using time-dependent density functional theory. The calculations are carried out on a three-dimensional lattice and performed both with and without a constraint on the density. The method has no adjustable parameters, and its only input is the Skyrme effective nucleon-nucleon interaction. While the microscopic density constrained time-dependent Hartree-Fock calculations lie closer to the experimental data than standard fusion systematics, they underpredict the experimental data significantly.
Study on the Network Management of Time System in Power Grid

Based on the technology and application of power grid time unification system,which distributes precision time through SDH network,this paper introduces the system configuration,alarm,performance,security and other basic functions of network management system,discusses the automatic routing and the extraction of automatic configuration, put forward the design scheme of network management center and data center.The practice shows that the time system fully meets the requirements of power grid.
No Clash of Constitutional Values: Respecting Freedom and Equality in Public University Sexual Assault Cases

There is a always a degree of tension between Equality and Freedom. For example, Equality prohibits discrimination against homosexuals and requires same-sex marriage, but Freedom prohibits the prescription of political orthodoxy and requires respect for those who disagree on religious grounds. Similarly, in the context of student sexual assault on a public university campus, Equality requires the institution to remedy the sex discrimination against the victim/survivor by disciplining the perpetrator; Freedom requires extensive due process protections before the alleged perpetrator can be disciplined.Unfortunately, when confronted with sexual assaults on campus, public institutions frequently have ignored Equality. After the decline of the in loco-parentis doctrine, Universities have tolerated a student life culture that emphasizes heavy drinking and casual sex. Such an environment does not prevent sexual assault and, indeed, indirectly encourages it. When students did come forward with allegations of sexual assault, campus officials often failed to: (1) provide adequate psychological counseling; (2) grant accommodations such as changes in class schedule or housing; or (3) prevent retaliation by the alleged perpetrator’s supporters. If a victim survivor wished to pursue justice against the alleged attacker, the university often simply referred them to the criminal justice system where police and prosecutors would not pursue ambiguous cases. If the school initiated student disciplinary proceedings, it was often a horrific experience for the victim/survivor. Sadly, at some institutions, the alleged perpetrator’s status as an athlete or the child of a wealthy donor apparently influenced the decision to pursue discipline or the sanction involved.Given the inadequate responses of institutions to the problems of sexual assault, advocates and policy makers justifiably demand universities do more. Quite simply, public schools have a moral and constitutional obligation to change the culture so that sexual assault is less common, support the victim/survivors, and facilitate the victim/survivors pursuit of justice. Trustees, administrators, and faculty members must do more. Yet, while there is a broad consensus that Equality requires more, some believe public institutions must choose between Equality and Freedom. Pursuing justice for the victims/survivors requires abandonment or a significant diminishment of due process protections. Protecting the rights of the accused student means further trauma for the victim/survivor or, worse, a rapist goes free.This is a false choice. There is no clash of constitutional values. The Constitution does not require public institutions to choose between Equality and Freedom. To the contrary, the Constitution requires a public university to honor both choices. Indeed, preferring Equality over Freedom or Freedom over Equality is a constitutional violation. The purpose of this Article is to demonstrate how a public institution must respect both Equality and Freedom in the context of a student sexual assault case.
Nitrogen dioxide causes pulmonary arterial relaxation via thiol nitrosation and NO formation.

Micromolar concentrations of nitrogen dioxide (NO2), a key metabolite of nitric oxide (NO) and peroxynitrite (ONOO-), were observed to cause a prolonged relaxation of isolated endothelium-removed rings of bovine pulmonary arteries (BPA) precontracted with 30 mM potassium. Relaxation to NO2 was markedly inhibited by 1 microM hemoglobin (Hb), 10 microM methylene blue (MB), and 10 microM LY-83583. The response to NO2 was enhanced in the presence of 1 mM reduced glutathione (GSH) or cysteine. The addition of NO2 to Krebs bicarbonate buffer (under 95% N2-5% CO2) containing 1 mM GSH or BPA resulted in an increase in NO formation (measured in head space gas). Relaxation to NO2 and NO formation were markedly decreased after GSH depletion by pretreatment of BPA with diethyl maleate. A high-performance liquid chromatography analysis of the products formed immediately after the addition of NO2 to GSH detected a previously isolated (but not identified) potent relaxing agent formed by a reaction of GSH with ONOO-, and...
Chronic Lymphocytic Leukemia at the Genomic Level

Chronic lymphocytic leukemia (CLL), a cancer of the B lymphocytes, commonly occurs in adults in Western countries. The Rai and Binet staging systems were first employed to classify CLL based on its progression. Later, immunoglobulin variable region (IgVH) mutation status and ZAP-70 status were used as prognostic markers to indicate disease severity. Cytogenetic analyses have identified many chromosomal abnormalities that play a major role in determining the progression and outcome of CLL. Some frequently occurring abnormalities are 17p, 11q, and 13q chromosomal deletions. These factors all play a critical role in determining not only life expectancy but also the therapy course for patients. However, CLL is a very heterogeneous disease and requires deeper insight at the molecular and genetic levels to predict disease outcome. The advent of whole-genome sequencing and whole-exome sequencing ushers in a new era in the treatment of CLL. This chapter will summarize the recent major findings in the literature, including consideration of gene mutations and deletions and their effects on therapy. These genetic profiles may prove useful as potential targets for personalized therapy and better cure rates.
Ethical Implications of Electronic Communication and Storage of Client Information

New technologies are transforming commerce in the United States every day. The legal profession is no exception. In fact, in many ways, law offices epitomize the ways in which technology can help make companies more efficient, and even more secure. But with new technologies come new risks that, if not addressed, can threaten a client's information and, consequently, a lawyer's good standing and reputation. The increased utilization of technology by the legal profession raises a multitude of ethical considerations. Lawyers, and indeed their entire offices, should be aware of their state's current ethics rules, as well as recent guidance offered by the ABA and ethics bodies in other jurisdictions.
Ubiquitous computing using wireless broadcast

Ubiquitous computing applications collect information from a variety of sources so as to provide behavior that is tailored to the user's context. Typically, client devices connect through appropriate middleware and wireless infrastructure to a variety of services and data sources and, increasingly, local sensor data. In this paper, we present a different approach to constructing ubiquitous computing applications that relies on wireless broadcasting of information by the infrastructure. Clients silently listen to these broadcasts and harvest the data they need. We believe this complementary approach exhibits promising properties for scalability and privacy. All clients receive the same data and use what they need solely by listening and without compromising their presence. We have constructed a broadcast infrastructure in our office building and, together with colleagues, have developed three applications that demonstrate the promise of the approach.
Governance, Economic, Social and Environmental Sustainability of Farming Enterprises of Different Juridical Type in Bulgaria

The issue of assessment of absolute and comparative sustainability of major farming structures is among the most topical for researchers, farmers, investors, administrators, politicians, interests groups and public at large. Despite that practically there are no assessments on sustainability level of Bulgarian farms of different juridical type in conditions of European Union Common Agricultural Policy implementation. This article applies a holistic framework and assesses absolute and comparative sustainability of Bulgarian farming enterprises of different juridical type. Initially the method of the study is outlined, and overall characteristics of surveyed holdings presented. After that an assessment is made of integral, governance, economic, social, environmental sustainability of farming structures of different juridical type. Next, structure of farms with different sustainability levels is analyzed. Finally, conclusion from the study and directions for further research and amelioration of sustainability assessments suggested.
P-Stereogenic Bicyclo[4.3.1]phosphite Boranes: Synthesis and Utility of Tunable P-Tether Systems for the Desymmetrization of C2-Symmetric 1,3-anti-Diols

The development of P-stereogenic bicyclo[4.3.1]phosphite borane tether systems for the desymmetrization of C2-symmetric dienediols is reported. This report highlights preliminary studies including tether installation and removal as well as chemoselective functionalization of the exocyclic olefin via diimide reduction or cross-metathesis. Most notably, a divergent oxidation strategy allows for the transformation of the bicyclic phosphite borane complexes to the corresponding phosphate or thiophosphate systems, highlighting the electronic attenuation of this P-tether system.
Introduction to the Special Issue of the Councilor on Economic Education

Written by the guest editor, Mary Beth Henning, this is the introduction to the special issue of The Councilor focused on economic education.
Integrating Function‐Directed Treatments into Palliative Care

The growing acceptance of palliative care has created opportunities to increase the use of rehabilitation services among populations with advanced disease, particularly those with cancer. Broader delivery has been impeded by the lack of a shared definition for palliative rehabilitation and a mismatch between patient needs and established rehabilitation service delivery models. We propose the definition that, in the advanced cancer population, palliative rehabilitation is function-directed care delivered in partnership with other clinical disciplines and aligned with the values of patients who have serious and often incurable illnesses in contexts marked by intense and dynamic symptoms, psychological stress, and medical morbidity to realize potentially time-limited goals. Although palliative rehabilitation is most often delivered by inpatient physical medicine and rehabilitation consultation/liaison services and by physical therapists in skilled nursing facilities, outcomes in these settings have received little scrutiny. In contrast, outpatient cancer rehabilitation programs have gained robust evidentiary support attesting to their benefits across diverse settings. Advancing palliative rehabilitation will require attention to historical barriers to the uptake of cancer rehabilitation services, which include the following: patient and referring physicians' expectation that effective cancer treatment will reverse disablement; breakdown of linear models of disablement due to presence of concurrent symptoms and psychological distress; tension between reflexive palliation and impairment-directed treatment; palliative clinicians' limited familiarity with manual interventions and rehabilitation services; and challenges in identifying receptive patients with the capacity to benefit from rehabilitation services. The effort to address these admittedly complex issues is warranted, as consideration of function in efforts to control symptoms and mood is vital to optimize patients' autonomy and quality of life. In addition, manual rehabilitation modalities are effective and drug sparing in the alleviation of adverse symptoms but are markedly underused. Realizing the potential synergism of integrating rehabilitation services in palliative care will require intensification of interdisciplinary dialogue.
Fuel cycle analysis of Advanced Burner Reactor with breed-and-burn thorium blanket

Abstract The Seed-and-Blanket (SB it is few percent higher than that of the 2-stage PWR-ABR system. Approximately 7% of the thorium fed to the blanket is converted into energy, which makes the thorium fuel utilization approximately 12 times the utilization of natural uranium in PWRs. A comprehensive fuel cycle evaluation performed with the methodology developed by the recent U.S Department of Energy’s Nuclear Fuel Cycle Evaluation and Screening campaign concludes that the PWR-S&B system has similar fuel cycle performance characteristics as the PWR-ABR system. The S&B concept may potentially feature improved economics and resource utilization relative to the ABR.
Current and historical land use influence soil-based ecosystem services in an urban landscape

Urban landscapes are increasingly recognized as providing important ecosystem services (ES) to their occupants. Yet, urban ES assessments often ignore the complex spatial heterogeneity and land-use history of cities. Soil-based services may be particularly susceptible to land-use legacy effects. We studied indicators of three soil-based ES, carbon storage, water quality regulation, and runoff regulation, in a historically agricultural urban landscape and asked (1) How do ES indicators vary with contemporary land cover and time since development? (2) Do ES indicators vary primarily among land-cover classes, within land-cover classes, or within sites? (3) What is the relative contribution of urban land-cover classes to potential citywide ES provision? We measured biophysical indicators (soil carbon [C], available phosphorus [P], and saturated hydraulic conductivity [Ks ]) in 100 sites across five land-cover classes, spanning an ~125-year gradient of time since development within each land-cover class. Potential for ES provision was substantial in urban green spaces, including developed land. Runoff regulation services (high Ks ) were highest in forests; water quality regulation (low P) was highest in open spaces and grasslands; and open spaces and developed land (e.g., residential yards) had the highest C storage. In developed land covers, both C and P increased with time since development, indicating effects of historical land-use on contemporary ES and trade-offs between two important ES. Among-site differences accounted for a high proportion of variance in soil properties in forests, grasslands, and open space, while residential areas had high within-site variability, underscoring the leverage city residents have to improve urban ES provision. Developed land covers contributed most ES supply at the citywide scale, even after accounting for potential impacts of impervious surfaces. Considering the full mosaic of urban green space and its history is needed to estimate the kinds and magnitude of ES provided in cities, and to augment regional ES assessments that often ignore or underestimate urban ES supply.
Arming Schoolteachers: What Do We Know? Where Do We Go From Here?

An editorial is presented which addresses the authors' views about a call to arm schoolteachers in America with firearms as a means of preventing school shootings, and it mentions a mass shooting event at a school in Parkland, Florida. Gun violence prevention research is examined, along with the impact that arming teachers might have on child development, student learning, and the school environment. School security is assessed, along with safety measures.
Mitochondrial Electron Transport Enzymes in Normal and Leukemic Human Leukocytes

Assays of TD transhydrogenase and succinate cytochrome C reductase carried out on the homogenate of normal and leukemic human leukocytes and on the 1.5 M. fraction (fraction 3) of a continuous sucrose density gradient analysis of a crude mitochondrial fraction, provided strong evidence for the mitochondrial location of TD transhydrogenase. A slightly higher activity of these enzymes was found in the homogenate of cells from chronic lymphocytic and acute leukemia compared to those of normal polymorphonuclear leukocytes, normal lymphocytes, and cells from chronic myeloid leukemia. These differences were very much more marked when purified mitochondrial fractions from these cells were examined. The significance of these findings is discussed.
Filter paper-based spin column for low throughput nucleic acid purification

We described a method of recharging used spin column or assembling homemade spin column using filter paper as binding material for low throughput nucleic acid purification. We evaluated the efficiency of filter paper based spin columns in the purification of different type of nucleic acids. For instance, by following protocols of respective commercial kits, we found that filter paper to be an effective binding material for purification of many types of nucleic acids, including plant genomic DNA, plant total RNA, PCR product, and DNA from agarose gels. We also found that filter paper has a weak binding affinity to plasmid DNA in tested miniprep protocols. Also, we present the protocols of using filter paper recharged spin column or homemade spin column for low throughput purification of plant genomic DNA and plant total RNA with commercial kit buffer leftover and less expensive homemade buffer.
Neutropenia at the time of subcutaneous port insertion may not be a risk factor for early infectious complications in pediatric oncology patients.

Abstract Background The risk of infection associated with subcutaneous port (SQP) placement in patients with neutropenia remains unclear. We reviewed the rate of early infectious complications ( Methods Baseline characteristics and infectious complications were compared between groups using univariate and multivariate analyses. Results A total of 614 SQP were placed in 542 patients. Compared to nonneutropenic patients, those with neutropenia were more likely to have leukemia (n = 74, 94% vs n = 268, 50%), preoperative fever (n = 17, 22% vs n = 25, 5%), recent documented infection (n = 15, 19% vs n = 47, 9%), and were younger (81 vs 109 months) (p values Conclusion SQP placement appears safe in most neutropenic patients. Type of study Retrospective comparative study. Level of evidence Level III.
Soot Morphology and Nanostructure in Complex Flame Flow Patterns via Secondary Particle Surface Growth.

Abstract While the majority of studies explore soot formation in relatively simple, one-dimensional flames, most real-world flames consist of complex flows defined by large-scale turbulent eddies, recirculating flow patterns, and buoyancy effects. The effects of complex flow on soot physicochemical properties are poorly understood. This work employs an inverted gravity flame reactor (IGFR) to compare differences in soot growth between a one-dimensional laminar diffusion flame and a recirculating flame. Computational fluid dynamics (CFD) and experimental observations show particle oscillations between (i) a rich region with a high concentration of surface growth species, and (ii) a high-temperature oxidation region. Transmission electron microscopy (TEM) shows a significant difference in final primary particle diameter, where the one-dimensional flame produces primary particles 10–25 nm in diameter and the recirculating flame produces primary particles 25–75 nm in diameter. Additionally, larger primary particles from the recirculating flame contain both single and multiple cores. We propose that due to the spheroidal shape of the large primary particles, the secondary surface growth is primarily a result of polyaromatic hydrocarbon (PAH) condensation during re-entrainment of mature soot into the fuel-rich region followed by subsequent liquid layer carbonization in the high-temperature environment of the flame front. The recirculating flow patterns in the IGFR and repeated particle growth/oxidation cycle can serve as a model for soot formation in the large-scale flames with complex flow patterns, such as forest fires, coal fire plants, and other sources.
78. APPLICANTS? WE HAVE AN APP FOR THAT!

Background Large amounts of information are provided to applicants during the residency interview process. It is important to share this information in an efficient, environmentally sound, and engaging manner. Preparing information packets requires significant administrative time and results in discarded paper or unused flash-drives. OBJECTIVE We sought to eliminate paper documents, minimize administrative effort, and streamline communication during interview season. Methods With the assistance of LegitApps Company we designed an app for Android and Apple devices that allows us to communicate in real time with applicants. The app delivers all required documentation prior to the applicant's arrival. It provides interview day schedule details and logistics, maps to their specific pre-interview dinner, and helps with navigating our city (finding hotels, identifying places to eat, highlighting fun things to do, etc). An easy to complete interview day survey is automatically pushed to all applicants at the end of the day. After initial programming, only minimal maintenance was needed by our administrative staff throughout the season. Results The app was downloaded 522 times this season. Based on results from the end-of-the-day survey, almost all 353 applicants downloaded the app. They appreciated the streamlined communication and hub for information. They used it to find Uber rides, book hotels, explore the city, and to prepare for their interview day. By eliminating paper, we saved money and manpower, allowing our staff to dedicate their time to the applicant experience. Survey comments include: “I appreciated the UM Pediatrics App, as it made the resources easy to access and reference throughout the day” and “I liked the App and that you tried to save some trees and not print out all of the information.” Conclusion The app successfully conveyed information efficiently to applicants and decreasing the administrative workload. We plan to expand the app to include our fellowship programs and are working with other programs at our institution to develop similar apps for their programs.
Lattice QCD on Intel® Xeon PhiTM Coprocessors

Lattice Quantum Chromodynamics (LQCD) is currently the only known model independent, non perturbative computational method for calculations in the theory of the strong interactions, and is of importance in studies of nuclear and high energy physics. LQCD codes use large fractions of supercomputing cycles worldwide and are often amongst the first to be ported to new high performance computing architectures. The recently released Intel Xeon Phi architecture from Intel Corporation features parallelism at the level of many x86-based cores, multiple threads per core, and vector processing units. In this contribution, we describe our experiences with optimizing a key LQCD kernel for the Xeon Phi architecture. On a single node, using single precision, our Dslash kernel sustains a performance of up to 320 GFLOPS, while our Conjugate Gradients solver sustains up to 237 GFLOPS. Furthermore we demonstrate a fully ’native’ multi-node LQCD implementation running entirely on KNC nodes with minimum involvement of the host CPU. Our multi-node implementation of the solver has been strong scaled to 3.9 TFLOPS on 32 KNCs.
(DOCUMENTO) Cartas para la historia: El epistolario de los Carrillo de Albornoz y Bravo de Lagunas, condes de Montemar, en el ocaso del imperio español en América, 1761-1799

En este articulo pretendemos dar a conocer una importante coleccion de cartas para el estudio de la historia del imperio espanol de finales del siglo XVIII, ubicadas en la biblioteca de la Universidad de Illinois en Urbana-Champaign, Estados Unidos, pero subidas y en acceso gratuito en el portal llamado The Conde de Montemar Letters.1 Se trata de alrededor de 300 cartas de la familia del Conde de Montemar, Diego Jose Carrillo de Albornoz y Bravo de Lagunas V conde de Montemar, cubriendo desde 1761 a 1799.
The Affordable Care Act and Ethnic Disparities in Colorectal Cancer Screening.

Introduction Cost sharing can deter the use of health services and act as a potential contributor to racial/ethnic disparities in cancer. The Affordable Care Act required most health plans to cover, without cost sharing, preventive services, including colorectal cancer screening. Population-based data were used to estimate the impact of the Affordable Care Act's cost-sharing provision (together with other Affordable Care Act provisions targeting preventive care) on ethnic disparities in colorectal cancer screening, comparing Hispanics with non-Hispanics. Methods An interrupted time series quasi-experimental analysis was used to examine ethnic differences in colorectal cancer screening pre- and post-implementation of the Affordable Care Act (analysis performed in 2018). The study cohort included insured individuals aged 50–64 years who participated in the Medical Expenditure Panel Survey from 2007 through 2015 (n=44,343). Results During the pre–Affordable Care Act period, screening rates decreased annually for non-Hispanics by −0.38 per 100 adults per year (95% CI= −0.55, −0.22) but remained level for Hispanics (annual trend per 100 adults: 0.01, 95% CI= −0.34, 0.35). After cost sharing was eliminated in 2011, colorectal cancer screening rates increased for both Hispanics (by 1.29 per 100 adults, 95% CI=0.69, 1.89) and non-Hispanics (by 0.58 per 100 adults, 95% CI=0.18, 0.99). The difference in trend increases between Hispanics and non-Hispanics was not statistically significant (0.70%, 95% CI= −0.24, 1.64). Conclusions These findings suggest that Affordable Care Act implementation resulted in increased colorectal cancer screening; however, the effect of the law was not significantly different between Hispanics and non-Hispanics. These results provide indications that more needs to be done to reduce racial/ethnic disparities in colorectal cancer screening.
Synthesis of High-Quality Monolayer MoS2 by Direct Liquid Injection

We report the synthesis of high-quality single monolayer MoS2 samples using a novel technique that utilizes direct liquid injection (DLI) for the delivery of precursors. The DLI system vaporizes a liquid consisting of a selected precursor dissolved in a solvent into small, micron-sized droplets in an expansion chamber maintained at a selected temperature and pressure, before delivery to the deposition chamber. We demonstrate the synthesis of monolayer MoS2 on SiO2/Si substrates using the DLI technique with film quality superior to exfoliated samples or those grown by traditional tube furnace chemical vapor deposition (CVD) methods. Photoluminescence measurements of DLI monolayers exhibit consistently brighter emission, narrower line width, and higher emission energy than their exfoliated and CVD counterparts. Conductive atomic force microscopy identifies a defect density of 8.3 × 1011/cm2 in DLI MoS2, lower than the measured density in CVD material and nearly an order of magnitude improvement over the exfoliated MoS2 investigated under the same conditions. The DLI method is directly applicable to many other van der Waals materials, which require the use of challenging low vapor pressure precursors, to the growth of alloys, and sequential growths of dissimilar materials leading to van der Waals heterostructures.
Educating the Scientific Workforce on Sex and Gender Considerations in Research: A National Scan of the Literature and Building Interdisciplinary Research Careers in Women's Health Programs

Background: This study was a national scan of education resources on integrating sex and gender considerations into research. The purpose was to assess capacity for educating researchers and to identify gaps, with implications for implementation of guidelines or mandates to consider sex and gender differences in research. Information sources were U.S. training programs in women's health and sex/gender difference research, Building Interdisciplinary Research Careers in Women's Health (BIRCWH), and published peer-reviewed biomedical literature. Materials and Methods: This descriptive study used multiple methods: a national survey and a comprehensive literature review. BIRCWH leaders responded to a survey regarding education on sex/gender difference research for BIRCWH scholars (response rate 100%, 20 of 20). A comprehensive literature review was conducted for 1993-2018. Results: Nearly half (45%) of BIRCWH institutions offered education on integrating sex or gender differences in clinical translational research; of those, roughly half (54%) offered in-person training and one-third (31%) offered content within existing for-credit courses. Respondents preferred online training (84%) to in-person offerings or reference materials (47% and 42% respectively). Published indexed literature on sex or gender differences has quadrupled since 1993, although growth in these publications remained flat in the most recent six years. Conclusions: Published resources to educate researchers on integrating sex and gender differences into medical research have increased, and BIRCWH programs connect scholars to national resources. Educational gaps remain due to limited access to curricula on applied research approaches, design, and methods for sex/gender difference research. BIRCWH programs desire curricula that are easily accessible online and asynchronously; sanctioned and supported by national thought leaders; linked to required training such as rigor and reproducibility; foster collaboration; and offer practical applications. Evidence-based, high-quality educational curricula and a dissemination plan are needed to enhance the adoption and integration of sex and gender into scientific endeavors.
Advances in diagnosis and treatment of urinary tract infection in children

Urinary tract infections (UTI) are one of the most common bacterial infections in children up to 30% of who suffer from recurrent infections during the first 6 to 12 months after initial UTI.UTI can be the first sign in almost 30% of children with urinary tract abnormalities, so UTI may be an outpost event of underlying renal disorders.UTI in infants is often associated with congenital abnormalities of the kidney and urinary tract, such as vesicoureteral reflux.Children with recurrent infection are prone to renal damaging and scarring, which further leads to end-stage renal disease.Therefore, early identification, timely treatment and reasonable management are extremely important to improving the prognosis.In this article, domestic and foreign relevant literature in recent years were reviewed to provide reference for diagnosis and treatment of UTI in children. Key words: Urinary tract infection; Child; Vesicoureteral reflux
Auto-antibodies against apolipoprotein A-1 block cancer cells proliferation and induce apoptosis

Auto-antibodies against apoA-1 (anti-apoA-1 IgGs) have been identified as important actors of atherosclerosis development through pro-inflammatory and pro-atherogenic properties and to also induce apoptosis in tumoral neuronal and lymphocyte derived cell lines through unknown mechanisms. The purpose of this study was to explore the cellular pathways involved in tumoral cell survival modulated by anti-apoA-1 antibodies. We observed that anti-apoA-1 antibodies induce growth arrest (in G2/M phase) and cell apoptosis through caspase 3 activation, accompanied by a selective p53 phosphorylation on serine 15. RNA sequencing indicated that anti-apoA-1 IgGs affect the expression of more than 950 genes belonging to five major groups of genes and respectively involved in i) cell proliferation inhibition, ii) p53 stabilisation and regulation, iii) apoptosis regulation, iv) inflammation regulation, and v) oxidative stress. In conclusion, anti-apoA-1 antibodies seem to have a role in blocking tumoral cell proliferation and survival, by activating a major tumor suppressor protein and by modulating the inflammatory and oxidative stress response. Further investigations are needed to explore a possible anti-cancer therapeutic approach of these antibodies in very specific and circumscribed conditions.
Epizootic Plague in Prairie Dogs: Correlates and Control with Deltamethrin.

The plague bacterium, Yersinia pestis, is a generalist pathogen of flea (Siphonaptera) vectors and mammalian hosts. In colonies of prairie dogs (PDs, Cynomys spp.), Y. pestis causes occasional epiz...
Differential impact of inpatient and outpatient palliative care on end-of-life outcomes in hospitalized patients with cancer.

24Background: Palliative care (PC) improves outcomes for patients with advanced cancer, and current ASCO guidelines recommend early outpatient referral. However, recent data show that PC teams at m...
Accelerated isotropic sub-millimeter whole-heart coronary MRI: Compressed sensing versus parallel imaging

Purpose To enable accelerated isotropic sub-millimeter whole-heart coronary MRI within a 6-min acquisition and to compare this with a current state-of-the-art accelerated imaging technique at acceleration rates beyond what is used clinically. Methods Coronary MRI still faces major challenges, including lengthy acquisition time, low signal-to-noise-ratio (SNR), and suboptimal spatial resolution. Higher spatial resolution in the sub-millimeter range is desirable, but this results in increased acquisition time and lower SNR, hindering its clinical implementation. In this study, we sought to use an advanced B1-weighted compressed sensing technique for highly accelerated sub-millimeter whole-heart coronary MRI, and to compare the results to parallel imaging, the current-state-of-the-art, where both techniques were used at acceleration rates beyond what is used clinically. Two whole-heart coronary MRI datasets were acquired in seven healthy adult subjects (30.3 ± 12.1 years; 3 men), using prospective 6-fold acceleration, with random undersampling for the proposed compressed sensing technique and with uniform undersampling for sensitivity encoding reconstruction. Reconstructed images were qualitatively compared in terms of image scores and perceived SNR on a four-point scale (1 = poor, 4 = excellent) by an experienced blinded reader. Results The proposed technique resulted in images with clear visualization of all coronary branches. Overall image quality and perceived SNR of the compressed sensing images were significantly higher than those of parallel imaging (P = 0.03 for both), which suffered from noise amplification artifacts due to the reduced SNR. Conclusion The proposed compressed sensing-based reconstruction and acquisition technique for sub-millimeter whole-heart coronary MRI provides 6-fold acceleration, where it outperforms parallel imaging with uniform undersampling. Magn Reson Med 71:815–822, 2014. © 2013 Wiley Periodicals, Inc.
Selected Bibliography on Marijuana and LSD-type Drugs

D AILY PAPERS, weekly magazines, and, increasingly, scientific literature proclaim the advent of marijuana and LSD-type drug use, warning of extreme hazards on the one hand and heralding remarkable benefits on the other. The evangelistic zeal of drug use proponents is rivaled only by the fervor of drug use suppressors. A nonexpert is hard put to evaluate available evidence intelligently because the psychological and scientific competence as well as the fanaticism is equal on both sides. Although the effect of drug use should be objectively determinable, it stubbornly remains a matter of controversy. Its persistence as an open question must result not from the limits of scientific inquiry but from unintentional, or at least unconscious, bias at emotional, intellectual, and even perceptual levels. How else can one reconcile opposing conclusions reached by respectable and competent analysts on such matters as whether LSD causes chromosome breakage? New York and Oregon cytogenetic groups, for example, say it does, while the Donner Laboratory and University of California Medical Center in San Francisco find no evidence of such breakage in their studies of LSD use.' Since the statistics on both sides seem airtight, it seems probable that in some way chromosome breaks at a raw data, observational level were unintentionally but mistakenly projected to be higher than or at control levels. In some instances, however, the techniques of persuasion employed by a drug use advocate or opponent undermines the speaker's claimed objectivity. For example, an attorney advisor for the United States Bureau of Narcotics addressing the National Student Association's First National Conference on Student Drug Involvement on August 16, 1967, handed out an issues paper' containing a subtle but significantly misleading reference.