cssi/SciSciGPT-SciSciNet huggingface dataset:
Dynamic Stereo Display And Interaction With Surfaces Of Medical Objects

Three-dimensional (3D) surface display is an alternate way of presenting to the physician information that is available in a sequence of two-dimensional CT or MRI scans. The aim is to present organs (or parts of organs) as they would appear if they were removed from the body, possibly cut open, and viewed from user-selected directions. In recent years there have been a number of papers discussing the clinical utility of this approach. In nearly all these papers the presentation of the surface consists of single images of the objects of interest. In these monoscopic images, depth perception is conveyed by the differential shading that is computed as if light were shining on the surface. This is augmented by the silhouette of the external features. Since shading is dependent on the distance from the light source and the angle of the surface to the light rays, these two effects may oppose each other, especially with perception of details in depths of cavities. In addition, the detail inside a cavity cannot be silhouetted at any viewing angle. Since many anatomical surfaces have significant information in the depths of cavities (e.g., orbits, neural foramina, cardiac cavities), the addition of stereoscopic depth perception and motion should be clinically useful. In a recent article, we presented 3D surface displays in stereo, thereby providing an important additional cue for correct 3D depth perception. Here we discuss issues of software and hardware for dynamic stereo display and for 3D interaction with the stereoscopic images.
Vectorizing a mesoscale meteorological model on the cyber 205

Abstract A mesoscale meteorological numerical model is chosen for performing the CYBER 205 vectorization technique. Three computational modules of the model (vertical diffusion, horizontal advection, and a computation including surface contrasts) are selected as working examples. A vectorization technique, denoted as “orthogonal vectorization,” is developed which is based on the model's computational structure and the CYBER 205's computer-parallelism and vector processing. Experimental results showed that for the selected examples, a speed-up by a factor of ten of the model execution on the CYBER 205 has been achieved. Provided further experiments and developments are performed, such an increase in executional speed is expected to produce profound impacts on mesoscale modeling in particular, and on atmospheric modeling in general.
Bispectral analysis of possessing chaotic motion

Abstract Bispectral analyses of the equations producing a chaotic Rossler attractor and the chaotic trajectories of a one-mode Galerkin approximation of the magnetically buckled beam are presented, yielding interesting consequences concerning chaotic system identification for driven oscillators and autonomous systems. Bicoherence spectra isolate the phase coupling between increasing numbers of triads of Fourier modes for a pure period doubling sequence route to chaos for the Rossler equations. Bicoherences from a period doubling-intermittency catastrophe route to chaotic motion are also observed for single frequency excitation for the buckled beam. Although the bicoherence successfully characterizes important aspects of the non-linearity of the Rossler attractor in the nonchaotic and chaotic regimes, where the primary non-linearity is quadratic, it only partially characterizes the magnetically buckled beam system because the dominant non-linearity is cubic.
Role of c-myc regulation in Zta-mediated induction of the cyclin-dependent kinase inhibitors p21 and p27 and cell growth arrest.

Latency-associated Epstein-Barr virus (EBV) gene expression induces cell proliferation. Unlike the latency associated genes, lytic gene expression in EBV, as well as other herpesviruses, elicits cell cycle arrest. Previous studies have shown that the EBV immediate early lytic transactivator, Zta, induces a G(0)/G(1) cell cycle arrest through induction of the cyclin-dependent kinase inhibitors, p21 and p27. Here we show that while EBV latency is intimately linked to activation of the protooncogene, c-myc, Zta represses c-myc expression. We also show that inhibition of c-myc expression is required for Zta-mediated growth arrest and for maximal induction of p21 and p27. Nevertheless, induction of p21 and p27 is also influenced by a c-myc-independent mechanism. A detailed genetic analysis of Zta's basic/DNA binding region identified two distinct subregions that contribute to full induction of p21 and p27. One subdomain influences p21 and p27 expression through the c-myc-dependent mechanism and the other subdomain influences p21 and p27 induction through the c-myc-independent pathway. Together, these studies further our understanding of the complex nature of Zta-induced growth arrest.
Permeability and single channel conductance of human homomeric ρ1 GABAC receptors

1. Homomeric human rho1 GABAC receptors were expressed in Xenopus oocytes and in human embryonic kidney cells (HEK293) in order to examine their conductance and permeability. 2. Reversal potentials of currents elicited by gamma-aminobutyric acid (GABA) were measured in extracellular solutions of various ionic composition to determine relative permeability of homomeric rho1 receptors. The rank order of anionic permeability was: SCN- > I- > NO3- > Br- > Cl- > formate (For-) > HCO3- > acetate (Ac-) approximately proprionate (Prop-) approximately isethionate (Ise-) approximately F- approximately PO4-. 3. In the oocyte expression system, relative permeabilities to SCN-, I-, NO3-, Br- and HCO3- were higher for rho1 GABAC receptors than alpha1beta2gamma2L GABAA receptors. 4. Expression of rho1 GABAC receptors in Xenopus oocytes and in HEK293 cells gave similar relative permeabilities for selected anions, suggesting that the expression system does not significantly alter permeation properties. 5. The pore diameter of the homomeric rho1 GABAC receptor expressed in oocytes was estimated to be 0.61 nm, which is somewhat larger than the 0.56 nm pore diameter estimated for alpha1beta2gamma2L GABAA receptors. 6. Homomeric rho1 GABA receptors expressed in oocytes had a single channel chord conductance of 0.65 +/- 0.04 pS (mean +/- s.e.m.) when the internal chloride concentration ([Cl-]i) was 20 mM. With a [Cl-]i of 100 mM, the single channel chord conductance was 1.59 +/- 0.24 pS. 7. The mean open time directly measured from 43 GABA-induced channel openings in six patches was 3. 2 +/- 0.8 s. The mean open time in the presence of 100 microM picrotoxin was 0.07 +/- 0.01 s (77 openings from 3 patches). 8. The differences observed in ionic permeabilities, pore size, single channel conductance and mean open time suggest that the rho1 homomeric receptor may not be the native retinal GABAC receptor reported previously.
Constraining the brachial plexus does not compromise regional control in oropharyngeal carcinoma

Background: Accumulating evidence suggests that brachial plexopathy following head and neck cancer radiotherapy may be underreported and that this toxicity is associated with a dose–response. Our purpose was to determine whether the dose to the brachial plexus (BP) can be constrained, without compromising regional control. Methods: The radiation plans of 324 patients with oropharyngeal carcinoma (OPC) treated with intensity-modulated radiation therapy (IMRT) were reviewed. We identified 42 patients (13%) with gross nodal disease <1 cm from the BP. Normal tissue constraints included a maximum dose of 66 Gy and a D05 of 60 Gy for the BP. These criteria took precedence over planning target volume (PTV) coverage of nodal disease near the BP. Results: There was only one regional failure in the vicinity of the BP, salvaged with neck dissection (ND) and regional re-irradiation. There have been no reported episodes of brachial plexopathy to date.
AN EVOLVING, MODEL-BASED QUALITY FUNCTION DEPLOYER

A dynamic, model-based decision making framework is described to support design and manufacture of engineered products. While the framework is inspired by the multiple stages of Quality Function Deployment, the presented framework differs by through the use of quantitative models relating engineering decisions to performance measures. The number of variables, model behavior, and model fidelity are intended to evolve as the design progresses. The Extensive Simplex Method is utilized to identify the feasible space of dynamic model and reveal trade-offs between the decision variables. The methods are demonstrated by various applications of product design and manufacturing process, including the case study of a mechanical actuator design. While promising, further research work is required to extend the methods to non-linear and probabilistic models as well as user interface design.© 2003 ASME
The Role of Recombination Activating Gene (RAG) Reinduction in Thymocyte Development in Vivo

Assembly of T cell receptor (TCR)α/β genes by variable/diversity/joining (V[D]J) rearrangement is an ordered process beginning with recombination activating gene (RAG) expression and TCRβ recombination in CD4−CD8−CD25+ thymocytes. In these cells, TCRβ expression leads to clonal expansion, RAG downregulation, and TCRβ allelic exclusion. At the subsequent CD4+CD8+ stage, RAG expression is reinduced and V(D)J recombination is initiated at the TCRα locus. This second wave of RAG expression is terminated upon expression of a positively selected α/β TCR. To examine the physiologic role of the second wave of RAG expression, we analyzed mice that cannot reinduce RAG expression in CD4+CD8+ T cells because the transgenic locus that directs RAG1 and RAG2 expression in these mice is missing a distal regulatory element essential for reinduction. In the absence of RAG reinduction we find normal numbers of CD4+CD8+ cells but a 50–70% reduction in the number of mature CD4+CD8− and CD4−CD8+ thymocytes. TCRα rearrangement is restricted to the 5′ end of the Jα cluster and there is little apparent secondary TCRα recombination. Comparison of the TCRα genes expressed in wild-type or mutant mice shows that 65% of all α/β T cells carry receptors that are normally assembled by secondary TCRα rearrangement. We conclude that RAG reinduction in CD4+CD8+ thymocytes is not required for initial TCRα recombination but is essential for secondary TCRα recombination and that the majority of TCRα chains expressed in mature T cells are products of secondary recombination.
Geographic Variation in Sarcoidosis in South Carolina: Its Relation to Socioeconomic Status and Health Care Indicators

Geographic patterns of sarcoidosis have been detected and studied on a global scale. However, the associations between these disease patterns and population characteristics have not been determined. The authors studied the geographic pattern of sarcoidosis in South Carolina and its relation to socioeconomic status (SES) and health status indicators. Hospitalization rates for the period 1985-1995 were used as geographic indicators of sarcoidosis. Rates were assessed for the 46 counties in South Carolina, adjusting for differences in SES, availability/accessibility of health care, diagnostic practices, and hospital utilization. Patterns in geographic variation were assessed based on physiographic characteristics and proximity to the Atlantic coastline. Significant variation was identified with an increase in sarcoidosis rates proximal to the Atlantic coastline. Population characteristics were identified that appeared to explain regional variation in sarcoidosis in Caucasians; however, regression analysis was unable to explain the regional differences in disease distribution by variation in SES, diagnostic practices, accessibility/availability, or hospital utilization in African Americans. These results suggest that the development of sarcoidosis is associated with a geographically linked risk factor in African Americans. This work supports the need for additional studies that will identify this risk factor(s).
STUDIES ON INFLAMMATION : XVI. ON THE FORMATION OF A CHEMOTACTIC SUBSTANCE BY ENZYMATIC ACTION.

Blood serum digested by trypsin yields split products which, when injected into the skin of normal rabbits, rapidly increase the permeability of small cutaneous vessels. This is likewise followed in the affected tissue by prompt local migration of polymorphonuclear leukocytes. The tryptic digest of blood serum can be purified by methods previously described (3). The resulting crystalline substance alters the permeability of the capillary wall and favors local migration of leukocytes in a manner similar to leukotaxine proper. The present observations indicate that leukotaxine, or a substance having at least identical biological properties, appears to have been formed by proteolytic enzymatic action on an otherwise relatively inactive blood serum. This finding serves as additional evidence in support of the view that leukotaxine, recovered from inflammatory exudates, is probably an intermediary product of protein catabolism.
A preliminary examination of the relationship between social networking interactions, internet use, and thwarted belongingness

Abstract. Background: Joiner's (2005) interpersonal-psychological theory of suicide hypothesizes that suicidal desire develops in response to the joint presence of thwarted belongingness and perceived burdensomeness. Aims: To consider the potential influence of online interactions and behaviors on these outcomes. Method: To address this, we administered an online protocol assessing suicidal desire and online interactions in a sample of 305 undergraduates (83.6% female). We hypothesized negative interactions on social networking sites and a preference for online social interactions would be associated with thwarted belongingness. We also conducted an exploratory analysis examining the associations between Internet usage and perceived burdensomeness. Results: Higher levels of negative interactions on social networking sites, but no other variables, significantly predicted thwarted belongingness. Our exploratory analysis showed that none of our predictors were associated with perceived burdensomeness after a...
POPULATION STUDIES OF FOUR SPECIES OF MOLLUSCS IN THE MADISON RIVER, YELLOWSTONE NATIONAL PARK1

Population statistics were calculated for natural populations of Physa gyrina, Gyraulus deflectus, Valvata humeralis, and Pisidium compressum. Total net production calculated for model populations was within 10% of the value calculated graphically. Data showed a generally good fit to the model curve. The average of the two methods of determining total annual net production of the gastropods was 5.150 g/m2. Assuming an efficiency of 0.25, total gastropod assimilation was approximately 10% of the annual net primary production. Growth rates apparently were not limited by food supply. Mortality rates were highest in spring and summer and lowest in winter with the principal causes predation and loss during high water. Reproductive periods of Physa, Gyraulus, and Pisidium extended from spring to fall; Valvata reproduction was largely limited to August.
EFFECTS OF SUBINGUINAL VARICOCELE LIGATION ON SPERM CONCENTRATION, MOTILITY AND KRUGER MORPHOLOGY

AbstractPurpose: We examined the effects of varicocelectomy on semen parameters in 30 subfertile men, with emphasis on potential changes in sperm count, motility and morphology as measured by Kruger's strict morphologic criteria.Materials and Methods: A total of 30 patients underwent subinguinal varicocelectomy (25 bilateral and 5 unilateral). Preoperative and postoperative sperm density, motility and morphology were analyzed. Preoperative follicle-stimulating hormone, luteinizing hormone and testosterone levels were measured and compared to those of fertile volunteers enrolled in our sperm donation program. Pregnancy rates after varicocelectomy were also examined. The Wilcoxon signed rank test was used to measure levels of statistical significance in all analyses.Results: We found that sperm density and motility improved significantly (p 0.05) only in men with clinical bilateral varicoceles. No differences were observed in values among testoster...
Evaluating the Software Architecture Competence of Organizations

An organization is architecturally competent if it has the ability to acquire, use and sustain the skills and knowledge necessary to carry out architecture-related practices that lead to systems that serve the organization's business goals. This paper presents some principles of architecture competence, based on four models that aid in explaining, measuring, and improving the architecture competence of an individual or an organization with respect to these principles, The principles are based on a set of fundamental beliefs about software architecture.
A particle filter for tracking two closely spaced objects using monopulse radar channel signals

For the case of a single resolved target, monopulse-based radar sub-beam angle and sub-bin range measurements carry errors that are approximately Gaussian with known covariances, and hence, a tracker that uses them can be Kalman based. However, the errors accruing from extracting measurements for multiple unresolved targets are not Gaussian. We therefore submit that to track such targets, it is worth the effort to apply a nonlinear (non-Kalman) filter. Specifically, in this letter, we propose a particle filter that operates directly on the monopulse sum/difference data for two unresolved targets. Significant performance improvements are seen versus a scheme in which signal processing (measurement extraction from the monopulse data) and tracking (target state estimation from the extracted measurements) are separated.
A Comparison of Tests of the Independence of Two Covariance-Stationary Time Series

Abstract The approximate slopes of several tests of the independence of two covariance stationary time series are derived and compared. It is shown that the approximate slopes of regression tests are at least as great as those based on the residuals of univariate ARIMA models, and that there are cases in which the former are arbitrarily great while the latter are arbitrarily small. These analytical findings are supported by a Monte Carlo study that shows that in samples of size 100 and 250 the asymptotic distribution theory under the null hypothesis is adequate for all tests, but under alternatives to the null hypothesis the rate of Type II error for the test based on ARIMA model residuals is often more than double that of the regression tests.
High Temperature Implantation of Single Crystal Beta Silicon Carbide Thin Films

Ions of aluminum, gallium and nitrogen were implanted into (100) oriented β-SiC thin films at temperatures of 623K, 823K and 1023K. Rutherford backscattering/ion channeling analyses revealed that implantation of any one of the ionic species at 623K resulted in only slight crystal lattice damage. In comparison, implantation conducted using the same dosimetry and energy at room temperature resulted in extensive lattice damage; in the case of gallium, amorphization occurred. The backscattered yield from samples implanted at 1023K was nearly that of a virgin aligned spectra. This in situ annealing effect did not, however, result in the complete electrical activation of implanted species. In order to increase the percent of electrical activation, samples were annealed at 1473K for 1800s following implantation. Differential capacitance-voltage, spreading resistance and sheet resistance measurements were made in order to electrically characterize these layers. These measurements indicated the activation of p-type and n-type species in samples implanted with aluminum or gallium and nitrogen, respectively. The authors have previously reported p-type formation in β-SiC implanted with aluminum at room temperature following a 2073K - 300s anneal. By heating to 1023K during implantation and annealing at 1473K after implantation, improved structural and electrical properties have been achieved.
[Dynamic nature of coronary plaques and clinical outcomes in diabetic patients: is change in itself bad?].

0300-8932/$ – see front matter 2011 Sociedad Esp doi:10.1016/j.recesp.2011.03.016 Los eventos cardiovasculares aterotromboticos estan relacionados no solo con la gravedad de la estenosis luminal, sino tambien con la composicion de la placa. Esto ha llevado al concepto de la placa vulnerable, que hace referencia a las lesiones que tienen una mayor probabilidad de rotura y de causar sindromes clinicos. Las caracteristicas propias de la vulnerabilidad son el nucleo necrotico grande, la cubierta fibrosa fina o la inflamacion activa, entre otras. La diabetes mellitus, a traves de una serie de mecanismos, es un factor de riesgo bien conocido que comporta un aumento del riesgo cardiovascular. Estudios previos, en los que se ha utilizado la ecografia intravascular (IVUS) seriada para evaluar la aterosclerosis coronaria, han mostrado una asociacion entre la presencia de diabetes y no solo la mayor carga de placa, sino tambien su progresion mas rapida y el remodelado constrictivo inadecuado. Ademas, en los estudios en que se emplea histologia virtual de IVUS, los pacientes diabeticos presentan nucleos necroticos mas grandes y mayor prevalencia de fibroateromas de cubierta fina, unicos o multiples. En el articulo publicado en REVISTA ESPANOLA DE CARDIOLOGIA, Jimenez-Quevedo et al describen los cambios de la placa en 45 pacientes con diabetes mellitus tipo 2 y una enfermedad coronaria que fueron incluidos en tres ensayos prospectivos de stents, en los que se realizaron IVUS seriadas en la situacion basal y tras un seguimiento de 9 meses. Los autores estudiaron 237 segmentos coronarios que contenian placas no tratadas que causaban una estenosis leve (reduccion del diametro < 25%) y estaban situadas a una distancia de al menos 10 mm de otras lesiones tratadas anteriormente con stents. Basandose en el aspecto en la IVUS, las lesiones se clasificaron cualitativamente como blandas, fibrosas, calcificadas o mixtas. El cambio de tipo de placa (CTP) se definio como una diferencia en la categoria asignada a la lesion al comparar la exploracion de IVUS basal con la obtenida en el seguimiento. Ademas, los autores correlacionaron el CTP con los eventos clinicos mayores (muerte cardiaca, infarto de miocardio y
A 16 /spl times/ 16 pixel silicon on sapphire CMOS photosensor array with a digital interface for adaptive wavefront correction

We report on a 16 /spl times/ 16 pixel CMOS photosensor array fabricated in silicon on sapphire CMOS technology. The transparency of the substrate allows imaging from both the back and front side and opens new applications for CMOS active pixel sensor arrays. A digital asynchronous interface is employed to minimize the design complexity and the power consumption. The analog pixel value is encoded as a pulse density stream of address events. The multiple threshold MOS transistors available in this technology enable circuit optimizations for low power and low voltage operation. We characterize the pixel sensitivity and show experimental data from both back and front side imaging.
Guidelines for the successful management of fibromyalgia patients

Abstract The successful management of fibromyalgia starts with establishing a firm diagnosis, followed by an evaluation of all other comorbid pain conditions (e.g. osteoarthritis, temporomandibular pain disorder, migraine headaches, myofascial trigger points) and fibromyalgia associated comorbidities (e.g. restless leg syndrome, irritable bowel syndrome). Then, it is necessary to systematically go through a list of problems that need to be addressed: pain, sleep, fatigue, mood disorders, cognitive dysfunction, functional limitations, social functioning, prior therapies and expectations. The most fundamental issue in successful management is initiating patient directed therapies. This involves education regarding the nature of fibromyalgia, the various tools for treating different aspects of the disorder and the development of a constructive and flexible treatment program that will be modified according to the results. All fibromyalgia patients should be given a trial of medications that have been shown to help pain. Non-restorative sleep diminishes the effectiveness of the descending inhibitory pain pathway, thus effective treatment is an essential component of pain management, as well as helping fatigue and cognition. It is important to rule out treatable associated sleep disruptors such as restless legs syndrome and sleep apnea. The basis of attaining effective sleep is the patient's adherence to basic sleep hygiene measures. Cognitive behavioral therapy where feasible, should be pursued. Ideally, hypnotics should be used as a short-term bridge while the patient is establishing behavioral modifications. Regular gentle exercise has repeatedly been shown to benefit fibromyalgia patients and needs to be incorporated in every patient's management strategy. Practicing mindfulness is a useful strategy for minimizing stress and can be incorporated into gentle exercise in the form of yoga and Tai chi. Having fibromyalgia creates an existential crisis for most patients, the management of these clients can be a rewarding experience for the well-informed and empathetic physician.
Happy and fearful emotion in cues and targets modulate event-related potential indices of gaze-directed attentional orienting

The goal of the present study was to characterize the effects of valence in facial cues and object targets on event-related potential (ERPs) indices of gaze-directed orienting. Participants were shown faces at fixation that concurrently displayed dynamic gaze shifts and expression changes from neutral to fearful or happy emotions. Emotionally-salient target objects subsequently appeared in the periphery and were spatially congruent or incongruent with the gaze direction. ERPs were time-locked to target presentation. Three sequential ERP components were modulated by happy emotion, indicating a progression from an expression effect to a gaze-by-expression interaction to a target emotion effect. These effects included larger P1 amplitude over contralateral occipital sites for targets following happy faces, larger centrally distributed N1 amplitude for targets following happy faces with leftward gaze, and faster P3 latency for positive targets. In addition, parietally distributed P3 amplitude was reduced for validly cued targets following fearful expressions. Results are consistent with accounts of attentional broadening and motivational approach by happy emotion, and facilitation of spatially directed attention in the presence of fearful cues. The findings have implications for understanding how socioemotional signals in faces interact with each other and with emotional features of objects in the environment to alter attentional processes.
Simulation on large batch and small interactive digital computers

A simple model for determining the costs of simula tion on two types of simulation systems is developed. One system is the batch-oriented S360/CSMP system operating on an IBM 360/50 computer. The other system is an interactive simulation system operating on a DEC PDP-12 computer. The workload considered includes six problems of varying complexity and is "typical" of those simulation problems encountered in undergraduate and graduate simulation courses. The model indicates that if only a few simulation runs are required, the PDP-12 system is the more cost effective of two systems. The S360/CSMP system, how ever, rapidly becomes more cost effective as the number of simulation runs increases. The factors affecting various cost tradoffs are indicated, and the model is evaluated for a selected set of parameters.
Automating Operation of Large Electric Power Systems Over Broad Ranges of Supply/Demand and Equipment Status

One of the ultimate challenges in operating today’s electric power grids is in designing automation for managing the system as demand varies over broad ranges and the status of major equipment changes. These changes are often hard to predict and it is, therefore, fundamentally impossible to design for the worst case scenarios; such scenarios are not known due to the very combinatorial nature of the problem. One possible way forward is to pursue automation for facilitating system’s adjustments as the conditions vary. In this chapter we propose an extension of today’s hierarchical control of electric power grids as one direction toward such automation. The approach is strongly motivated by the recognition that it has become insufficient to rely solely on operators’ decisions; instead, more on-line information gathering and active decision making at various layers of the grid are needed. The proposed generalization is introduced by relaxing some critical assumptions underlying current operating practices, and by deriving layers of models so that each model can capture the events and phenomena in the power grid at the spatial and temporal scales that are appropriate for each level of decision. These models are used for quasi-stationary state estimation and automated control for the system to adjust smoothly to on-going changes. This is in sharp contrast to today’s approach in which automation is only used during normal operation, while during abnormal conditions major decisions are made by the humans.
The Segmentation of Therapeutic Populations in Oncology

The emergence of targeted therapies in oncology has enormous potential to improve care for individual patients and specific subpopulations. A consequence of these advances is the segmentation of oncology into numerous sub-types, often with small patient populations. In this research we document the growth of candidate therapeutics along with the resultant segmentation of oncology treatments, based on a querying of the PharmaProjects® database for all anti-cancer indications from 1995 through 2011, augmented with Centers for Disease Control and Prevention (CDC) incidence information. We find that the number of marketed oncology treatments has doubled since 1995 from 71 to 146, while the proportion of molecular entities in Phase II/ III programs with unidentified targets has declined from 56 percent to 28 percent. The number of anti-cancer compounds marketed or in active programs increased to 1,428 from 538, while active molecular targets under investigation have expanded from 99 to 265, with 590 distinct total targets explored over this period. We consider clinical, economic and development challenges emanating from the increasingly segmented oncology marketplace.
FIVE-YEAR ANALYSIS OF ADENOVIRUS 8 ANTIBODY LEVELS IN AN INDUSTRIAL COMMUNITY FOLLOWING AN OUTBREAK OF KERATOCONJUNCTIVITIS

Serum hemagglutination-inhibition (HI) antibody titers were monitored for five years with samples from 79 keratoconjunctivitis patients with type 8 adenovirus (AV-8) infection. Geometric mean antibody titers declined from 1:161 at the peak of the epidemic to 1:56 after five years. Computerized analysis of the decline in geometric mean antibody titer indicates that most patients will have a serum HI titer of 1:25 by 10 years after their clinical infection. These residual antibody levels and the consistent failure to document re-infection with AV-8 suggest that recurrent episodes of keratoconjunctivitis are caused by adenovirus serotypes other than type 8.
Deployment of STORM 3 Data Loggers to Monitor Water Quality

Sustainable water management decisions are often made on the support of water quantity and quality models with a focus on prediction uncertainty. Unfortunately, limited observational data severely constrains the design of accurate water models for these decisions. To address this challenge, this paper presents our initial efforts to deploy STORM 3 data loggers from WaterLOG to collect real-time and in-situ data at fine temporal granularities to monitor the pond at Lamar University in Beaumont, TX. We present the details about how to set up STORM 3, integrate H-377 water temperature sensor probe from WaterLOG, and validate collected water temperature data. Since July 2014, our deployed STORM 3 is collecting water temperature data once every 15 minutes. On-going research is underway to revise the deployment of our STORM 3, and to provide water temperature data for decision making on water sustainability management.
Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat.

AbstractRats with untreated diabetes mellitus are protected from gentamicin-induced nephrotoxicity. In order to evaluate the role of hyperglycemia, glycosuria, and polyuria in this phenomenon, miniosmotic pumps filled with insulin were implanted for 15 days in seven female Sprague-Dawley rats with streptozotocin-induced diabetes mellitus. Plasma glucose levels were successfully maintained under 126 mg/dl. To serve as the control group, eight age-matched diabetic (plasma glucose >400 mg/dl) rats had miniosmotic pumps placed delivering only Ringer's solution. Six days after placement of the pumps, gentamicin (40 mg/Kg/day) was administered to all animals for 9 days. The insulin-treated diabetic rats exhibited clear signs of nephrotoxicity by Day 6 of gentamicin, whereas the diabetic control group remained free from any functional or morphological evidence of proximal tubular damage throughout the 9 days of the aminoglycoside administration. At the end of the experiment, the creatinine clearance in the insul...
LUNG ULTRASOUND WITH POCKET DEVICE MAY DETECT SUBCLINICAL CONGESTION IN AMBULATORY HEART FAILURE PATIENTS

Pulmonary congestion is a common sign of heart failure (HF) and a prognostic marker for HF readmissions and mortality. While traditional methods to assess pulmonary congestion are insensitive, lung ultrasound (LUS) may detect subclinical pulmonary edema. During cardiology clinic visits 189 patients
Evolution alters the enzymatic reaction coordinate of dihydrofolate reductase.

How evolution has affected enzyme function is a topic of great interest in the field of biophysical chemistry. Evolutionary changes from Escherichia coli dihydrofolate reductase (ecDHFR) to human dihydrofolate reductase (hsDHFR) have resulted in increased catalytic efficiency and an altered dynamic landscape in the human enzyme. Here, we show that a subpicosecond protein motion is dynamically coupled to hydride transfer catalyzed by hsDHFR but not ecDHFR. This motion propagates through residues that correspond to mutational events along the evolutionary path from ecDHFR to hsDHFR. We observe an increase in the variability of the transition states, reactive conformations, and times of barrier crossing in the human system. In the hsDHFR active site, we detect structural changes that have enabled the coupling of fast protein dynamics to the reaction coordinate. These results indicate a shift in the DHFR family to a form of catalysis that incorporates rapid protein dynamics and a concomitant shift to a more f...
Reply to Dr. Goldzieher's comment on the new report

The former chairman of the Advisory Committee on Obstetrics and Gynecology to the Food and Drug Administration responds to Dr. Goldziehers analysis of his Committees report on oral contraceptives. Goldziehers criticisms are said to be based on his biases. The author comments on Goldziehers criticisms that the Committee avoids discussing comparative risks of oral contraceptives with other activities of the human female that there are discrepancies in the discussion of theoretical versus use-effectiveness that the Committee failed to point out the irrelevance of adverse reaction reports and that the Sartwell study contains inaccuracies. The author believes that the Committee successfully suppressed its personal prejudices in order to produce scholarly reports containing unbiased analyses of the available facts and will not accept Goldziehers implications that the Committee was biased.
Study on transformation test of low NO_X burner for 600MW tangentially fired boiler

In order to reduce the discharge amount of NOX for boiler,this paper expounds the basic Parameters and the whole test system of 600 MW tangentially fired boiler,and analyzes the influence of different oxygen content,different air distribution and different nitrogen content on NOX discharge and boiler efficiency.Test result proves that the discharge amount of NOX is relatively large when the oxygen content is 3.5,the air distribution method is shrinked-middle wind and the nitrogen content in coal is high;CO is generated when the oxygen content is low;the discharge consistency of NOX is inversely proportional to the formation amount of CO.
Study on visual cognitive characteristics in children with learning disability

【Objective】 To explore the visual cognitive characteristics in children with learning disability(LD).【Methods】 Participants included 42children with LD and 37control cases.All children had accepted WISC-R,the ability of visual distinguish,visual-motor integration test and were tested by PRVEP at five levels of spatial frequency.【Results】 The mean scores of VIQ,PIQ and FIQ of children with LD were poorer than those of controls(P0.01).Moreover,the poor ability of coding in children with LD had significantly 37% difference with the control.The mean scores of VMI in LD group and controls were 93±16,115±16,respectively.The visual distinguish error rate of LD group was greater than that of controls(P0.001).The latencies of P100at all five spatial frequencies were significantly prolonged in the LD group than in the normal children.【Conclusion】 LD children with average cognition capability still have poorer visual perception compared with the normal children.Detection specific visual perceptual in many aspects in children with LD could provide specific rehabilitative strategies.
Chanting Dharanis While Dreaming of Lilacs: Buddhism and Beijing in Gong Zizhen's Poems of 1839

Gong Zizhen’s (1792–1841) poetic sequence, Jihai zashi ( Poems of 1839 ), is noted for its subtle, sophisticated allusions to the poet’s wide-ranging intellectual interests, especially his erudite and innovative scholarship in the discipline of geographical studies. It also bears witness to his religious conversion to the esoteric doctrines of the Tiantai sect during the last decade of his life. This study argues that these two dimensions of his intellectual and spiritual life converge in many of the poems; moreover, they serve to complement the ideals of interethnic comity and cultural pluralism that Gong came to champion during his later years. This essay also demonstrates how these themes are also evident in Buddhist metaphors employed in poems addressed to Lingxiao, a Suzhou prostitute whom Gong took as a concubine. By tracing the interplay between the erotic, philosophical, and intellectual dimensions of the poems, this study aims to contribute to furthering the understanding of the structural and thematic coherence of the sequence as a whole.
Vasovasostomy: evaluation of four surgical techniques.

Four techniques of vasovasostomy were evaluated in two groups of twelve dogs each. In group 1, one side was anastomosed by a standard technique over a Silastic stent and the other side was anastomosed using a two-layer microsurgical technique. In group 2, one side was anastomosed by a standard technique without a stent and the other side was anastomosed using a one-layer microsurgical technique. Patency was evaluated by methylene blue injection distal to the anastomosis and was found to be about the same for all three groups in which anastomosis was performed without stents. The stented group had a high rate of obstruction. Histologic evaluation, however, showed superiority of both microsurgical techniques over each of the standard procedures.
Emergent Periodicity in a Field of Chaos

The synchronization of nonlinear oscillators is well-known and is a traditional topic in complex dynamical system theory. The synchronization of chaotic attractors is less well-known, but is of obvious interest in many applications to the sciences: physical, biological, and social. In a recent experimental study of coupled lattices of Rossler attractors, we were surprised to discover global periodic behavior in large regimes of the parameter space. This emergent periodicity in a field of chaos may be of significance in the origin of life and in many life processes. In this talk, we will explore the emergence of global periodicity and also the periodic windows in the bifurcation diagram of the Rossler attractor, which may be the local cause of this global behavior.
Improved measurements and analysis of the far-infrared spectrum of methanol-D 1 (CH 2 DOH) arising from trans- (e 0 ) to gauche- (e 1 & o 1 ) states

Abstract In this work the millimeter-wave (MMW) and far infrared (FIR) absorption spectrum for the asymmetrically deuterated Methanol (CH2DOH) species measured recently at a temperature of −60 °C with better accuracy and signal/noise (S/N) ratio than known before has been assigned for transitions originating at the lowest lying trans- to gauche-states. The entire spectrum for 50–1200 cm−1 has been re-recorded recently using the Synchrotron Radiation Source coupled with the Bruker Fourier Transform Infrared (FTIR) spectrometer with a resolution of about 0.001 cm−1 or better. Complete spectrum has not been exploited a great deal but it helped to entangle overlapping lines in the present work. This also fills the gap remaining in the usual FTIR in the range 400–500 cm−1. Hence it is expected to help the interacting partner for the Coriolis interaction encountered earlier. The assigned transitions mostly for the axial rotational angular momentum quantum number K + 1 ← K, both for R- and Q-sub bands for wide range of rotational angular momentum quantum number. The MMW spectrum has been recalibrated and assigned for a number of Q-branches. The assignments are confirmed rigorously using closed loop residual technique. The assigned rR and rQ lines have been analyzed in terms of polynomial expansion parameters. The new assignments are presented for about 750 transitions and a grand atlas of more than 1000 lines has been prepared which will be made available through the open source server at “research gate”. The present work should be useful in the area of astrophysical detection and further understanding of the energy relaxation pathways in the molecule.
MO-F-201-01: Panel Member

The goal of this session is to provide guidance to medical physicists undergoing the American Board of Radiology certification process in therapeutic medical physics. This panel discussion will focus on parts 2 (computer-based) and 3 (oral) of the examination. Unlike the latter portions of the exam which are specialty-driven, part 1 is universal for all medical physics fields and will not be addressed. This session is structured into different topics that aim to guide the participants on how to successfully prepare for the board exams. The subjects of discussion will include timing and strategies for exam preparation, crucial differences in preparing for the clinical computer-based exam versus the oral exam, what study tools are currently available for each, etc. The panel discussion format will allow the speakers to collectively present their experience and advice relating to each topic and foment audience participation. Learning Objectives: 1. Know the main differences between what is expected for parts 2 and 3 2. Know different resources for test preparation 3. Know how to formulate a plan to best study for each part based on the specific skill set the two parts require 4. Know how to best present his/her answers during the oral examination – demeanor, answer structure, etc.
Solitary fibrous tumour presenting as a submucosal colonic polyp: a new addition to the family of mesenchymal polyps of the gastrointestinal tract

Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm first described by Klemperer and Rabin in 1931 as a pleural-specific tumor.1 It has since been identified in several extra-pleural locations including abdominal cavity, soft tissue, mediastinum, leptomeninges, retroperitoneum, and orbit. Rare cases involving the liver, pancreas, lung, adrenal, bladder, prostate, testis, thyroid, salivary glands, and gastrointestinal (GI) tract have also been described. 2 Historically, some SFTs were termed hemangiopericytomas; however, this term has become obsolete and has been gradually replaced by the term SFT as recommended in the latest edition of the World Health Organization (WHO) classification of soft tissue and bone tumors.2 This article is protected by copyright. All rights reserved.
Dispute over the Applicable Scope of the Svalbard Treaty: A Chinese Lawyer's Perspective

As the Arctic is increasingly becoming one of the focus of international strategy, the Svalbard Treaty — one of the few international intergovernmental treaties in the Arctic area — has been getting more and more attention. Disputes over The Svalbard Treaty focus on the determination of its applicable scope, while the core of the dispute lies in how to understand the meaning of ‘territorial waters’ in the treaty. This paper, from China’s perspective, combining with two ideas of legal interpretation -subjective theory and objective theory, uses the methods of evolutionary interpretation, historical analysis and "rational contracting parties" analysis to arrival at a conclusion as following: the Svalbard Treaty shall apply to Svalbard’s fishery protection zone and continental shelf, and other contracting parties shall enjoy the non-discrimination rights given by the treaty in these two areas.
Accuracy of Pelvic Tilt Adjusted Anteversion Measurements in Imageless Navigation

Introduction Traditional methods of component positioning in total hip replacement (THR) utilize mechanical alignment guides which estimate position relative to the plane of the operating room table. However, variations in pelvic tilt alter the relationship between the anatomic plane of the pelvis and that of the table such that components placed in optimal position relative the table may not land within the classic anatomic “safe zone” described by Lewinnek. It has been suggested that navigation software should incorporate adjustments for the degree of pelvic tilt. Current imageless navigation software has this capability, however there is a paucity of data regarding the accuracy of this technology. Purpose We aimed to assess the accuracy of intra-operative pelvic tilt adjusted anteversion measurements as compared to unadjusted measurements. Methods 6-week post-operative Anteroposterior Pelvis radiographs from 27 consecutive primary THR were measured utilizing Ein-Bild-Roentgen-Analyse (EBRA-Cup®) hip analysis software (Figure 1) and a cross-table lateral radiograph (Figure 2). Inclination and anteversion values were recorded and direction of version was confirmed by assessment of cross-table lateral images. Values were compared with intra-operative measurements obtained via BrainLab® imageless navigation. Pelvic tilt adjusted and unadjusted anteversion measurements were recorded. Mean measurement error and standard error of the mean were determined and Pearson correlation coefficients were calculated. Results Navigated component inclination correlated with EBRA-Cup® derived inclination measurements (r = 0.4308, p = 0.02) with a mean error of 3.8°. Similarly, pelvic tilt adjusted anteversion correlated with EBRA-Cup® derived measurements (r = 0.65, p Conclusions Imageless navigation based anteversion measurements are more accurate when adjusted for pelvic tilt.