cssi/SciSciGPT-SciSciNet huggingface dataset:
Mapping suitability areas for concentrated solar power plants using remote sensing data

The political push to increase power generation from renewable sources, such as solar energy, requires knowing the best places to site new solar power plants with respect to the applicable regulatory, operational, engineering, environmental, and socioeconomic criteria. Therefore, we present applications of remote sensing data for mapping suitable areas for concentrated solar power (CSP) plants. Our approach uses satellite data from National Aeronautical and Space Administration’s Global Energy and Water Cycle Surface Radiation Budget project at a resolution of 1 deg for estimating global solar radiation for the study area. Then we develop a computational model built on a geographic information system (GIS) platform that divides the study area into a grid of cells and estimates the site suitability value for each cell by computing a list of metrics based on applicable site requirements using GIS data. The computed metrics include population density, solar energy potential, federal lands, and hazardous facilities. Overall, some 30 GIS datasets are used to compute eight metrics. The site suitability value for each cell is computed as an algebraic sum of all metrics for the cell with the assumption that all metrics have equal weight. Finally, we color each cell according to its suitability value. We present results for CSP that drives a stream turbine and parabolic mirror connected to a Stirling engine.
An Artificial Diet for Diaprepes abbreviatus (Coleoptera: Curculionidae) Optimized for Larval Survival

ABSTRACT The root weevil Diaprepes abbreviatus (L.) has been reared since 1992 on an artificial diet first reported in 1982. Recently, we have shown that several ingredients included in the original diet have little or no effect on insect performance. Here we examined the effects of 2 principal drivers (cottonseed meal and wheat germ) on weight gain and survival of larval D. abbreviatus in varying proportions along with a non-nutritive filler (cellulose). We employed a geometric design to evaluate amount and proportion combined with response surface models to identify optimal proportions for larval weight gain, larval survival, and development rate. All larval responses measured lead to the conclusion that cottonseed meal is the only major nutritive component, in addition to standard vitamin and salt mixes, required for a successful artificial diet for rearing larvae of D. abbreviatus to pupation. Supplemental material online at http://www.fcla.edu/FlaEnt/fe931.htm#InfoLink1.
Accounting for the water impacts of ethanol production

Biofuels account for 1‐2% of global transportation fuel and their share is projected to continue rising, with potentially serious consequences for water resources. However, current literature does not present sufficient spatial resolution to characterize this localized effect. We used a coupled agro-climatic and life cycle assessment model to estimate the water resource impacts of bioenergy expansion scenarios at a county-level resolution. The study focused on the case of California, with its range of agroecological conditions, water scarcity, and aggressive alternative fuel incentive policies. Life cycle water consumption for ethanol production in California is up to 1000 times that of gasoline due to a cultivation phase that consumes over 99% of life cycle water use for agricultural biofuels. This consumption varies by up to 60% among different feedstocks and by over 350% across regions in California. Rigorous policy analysis requires spatially resolved modeling of water resource impacts and careful consideration of the various metrics that might act to constrain technology and policy options.
Dealing with Arthritis as a Comorbidity in Cardiac Rehabilitation Programs

“Arthritis” literally means inflammation within a joint, but this term is often used to encompass a wide range of conditions affecting bones, joints, and connective tissues with unique pathogeneses, epidemiologies, and disease manifestations. As many as 20% of adults in the US and approximately 49% of those over age 65 years report that they have arthritis (1,2). Given the aging of our population, projected estimates suggest that close to 25% of the US adult population will be impacted by arthritis by 2030 (2). Not surprisingly, arthritis is the leading reported cause of disability in the US (3). Although many individuals presenting for cardiac rehabilitation (CR) will describe a history of “arthritis,” the rehabilitative health professional should attempt to understand what particular form of arthritis afflicts the patient to optimize their rehabilitation (Table 1). Rheumatoid arthritis (RA) and osteoarthritis (OA) are particularly pervasive and have specific implications for CR.
Determination of in vivo bioequivalence.

The May and June 2001 issues of Pharmaceutical Research contained three articles related to the determination of in vivo Bioequivalence (1-3). The articles discussed: (a) the bioequivalence of highly variable drugs, (b) novel metrics for direct comparison of bioequivalence study plasma curves, and (c) the role of a microemulsion vehicle on cutaneous bioequivalence.
Ge Healthcare in India: An Ultra(Sound) Strategy?

This case outlines the dilemma of V. Raja, president and CEO of GE Healthcare India, when the company’s ultrasound machines were implicated in many cases of prenatal sex determination. Even in the 21st century, Indian society favored males and many in India saw females as a burden on their families. Studies had shown that fewer and fewer girls were being born, with potentially catastrophic results for future Indian society. The reason: Many women were relying on ultrasound machines to determine the gender of their fetus and, if it were a girl, having abortions. Raja knew that GE Healthcare and ultrasound machines were providing much better medical care for Indians, particularly those in rural communities, and that the company was following all the rules and regulations to prevent this type of abuse. But he also understood the social issues that were involved. Ultrasound machine sales had enormous potential to help maintain GE’s market-leading position in India. But should the company step back from its aggressive sales strategy? How could Raja and the company alleviate the growing discontent among critics and the media against the practice of prenatal sex determination testing using GE’s ultrasound machines? What additional efforts did GE need to make to prove its intentions of promoting prenatal care? What other efforts should the company make to stop the illicit prenatal gender determination and resulting abortions? How could he protect the as yet untarnished image of GE as a responsible corporation going forward?
The Searching System for Wandering Demented Aged Person using GPS

We proposed a searching system for wandering demented aged person using GPS (Global Positioning System), PHS (Personal Handyphone System) and mobile PC (Personal Computer). There were three subsystems: one base station and two mobile terminals carried by the aged and his family. We focused our system on reducing the mental stress of the family in the sense that, in using our system, the family does not need further assistance from others. The independence of the family is very important. In order to construct this user-friendly system, the mobile terminal for the family consisted of only the necessary input keys and the static station included a touch panel. Furthermore, to clarify intuitively the geometrical relationship between the aged and 'carer-person' in the family, the mobile terminal was able to show their loci on the same digital map in real time, and was automatically able to change the scale of the map using a GIS (Geographic Information System). We were encouraged by the results of the application of our system to a search for the wandering demented aged person.
Clinical career ladders: Jewish Hospital of St. Louis

The clinical career ladder program developed for pharmacists at Jewish Hospital, a 500-bed tertiary-care teaching institution, is described. In 1983 the hospital's salary structure was re-evaluated. The pharmacy department seized this opportunity to create a clinical career ladder program that would accommodate the changing nature of the profession. Management informally interviewed staff members and developed their opinions into a proposal, which was accepted by the job evaluation committee. The career ladder has three levels. Level I pharmacists carry out basic practice duties. Level II pharmacists have additional responsibilities, notably maintaining a procedure manual, training, and performing an advanced clinical function. At level III, pharmacists develop, implement, and manage a clinical program. Pharmacists are promoted for having achieved a certain level of practice. They are not given new duties upon promotion; rather, they have already taken them on. Advancement can occur at any speed, and it is possible to voluntarily step back to a previous level. The novelty of the program, design flaws, and a series of modifications have created some frustration and confusion among the staff, but the career ladder is otherwise a success. Recruitment has improved, the department's organizational chart is aligned more horizontally, and the pharmacists are being trained for nondistributive roles. In retrospect, management would not have based the program on staff interviews but would have established a formal committee. The effort needed to establish and adjust to a clinical career ladder is great but so is the potential payoff.
Corrosion Behavior of Angle Steel Galvanized Layer of Power Tower in NaCl Solution

Corrosion behavior of angle steel galvanized layer was studied in NaCl solution by Tafel linear extrapolation and accelerated corrosion test.Morphologies and corrosion products after corrosion were characterized by SEM,XRD.The results show that the corrosion current density of angle steel galvanized layer becomes larger when the solution temperature and the concentration of NaCl increase.The products of accelerated corrosion test can provide protection against chloride corrosion,and the corrosion rate become smaller with the extension of test time.Oxygen concentration cell corrosion of zinc layer is a slow corrosion process that can not form "eclipse pits" easily,while the primary cell of Zn-Fe corrosion is a quick corrosion process that can result in superficial "eclipse pits" easily,and the white corrosion products are mainly Zn5(OH)8Cl2·H2O.
Effect of post injections on mixture preparation and unburned hydrocarbon emissions in a heavy-duty diesel engine

Abstract This work explores the mechanisms by which a post injection can reduce unburned hydrocarbon (UHC) emissions in heavy-duty diesel engines operating at low-temperature combustion conditions. Post injections, small, close-coupled injections of fuel after the main injection, have been shown to reduce UHC in the authors’ previous work. In this work, we analyze optical data from laser-induced fluorescence of both CH2O and OH and use chemical reactor modeling to better understand the mechanism by which post injections reduce UHC emissions. The results indicate that post-injection efficacy, or the extent to which a post injection reduces UHC emissions, is a strong function of the cylinder pressure variation during the post injection. However, the data and analysis indicate that the pressure and temperature rise from the post injection combustion cannot solely explain the UHC reduction measured by both engine-out and optical diagnostics. The fluid-mechanic, thermal, and chemical interaction of the post injection with the main-injection mixture is a key part of UHC reduction; the starting action of the post jet and the subsequent entrainment of surrounding gases are likely both important processes in reducing UHC with a post injection.
Influence of adenosine on left ventricular performance in conscious dogs

Adenosine, a potent vasodilator of both the peripheral and coronary vasculature, is increasingly used to produce controlled hypotension in the clinical and experimental setting. To define the influence of adenosine on left ventricular (LV) performance in conscious closed-chest dogs were studied six chronically instrumented autonomically blocked animals before and after the administration of 0.3, 0.6, and 1.2 microM.kg-1.min-1 infusions of adenosine. Systolic performance was quantified by the end-systolic pressure-volume (Pes-Ves) and stroke work end-diastolic volume (SW-EDV) relations. Active diastolic performance was quantified by the time constant of LV relaxation (T), whereas passive diastolic properties were assessed by comparing LV pressures at a common LV volume. Despite a decrease of mean arterial pressure of 51 mmHg, adenosine did not change the slope of the Pes-Ves relation or the end-systolic volume at a pressure of 100 mmHg. The slope of the SW-EDV relation was also unchanged, and its volume axis intercept was slightly reduced. There were no differences in T or in the diastolic pressure at a common LV volume. Thus adenosine appears to have little influence on systolic or diastolic LV performance aside from its marked affect on afterload, indicating it is a useful agent for producing controlled hypotension.
An EEG Acquisition and Biomarker-Extraction System Using Low-Noise-Amplifier and Compressive-Sensing Circuits Based on Flexible, Thin-Film Electronics

This paper presents an electroencephalogram (EEG) acquisition and biomarker-extraction system based on flexible, thin-film electronics. There exist commercial, single-use, flexible, pre-gelled electrode arrays; however, these are fully passive, requiring cabling to transfer sensitive, low-amplitude signals to external electronics for readout and processing. This work presents an active EEG acquisition system on flex, based on amorphous silicon (a-Si) thin-film transistors (TFTs). The system incorporates embedded chopper-stabilized a-Si TFT low-noise amplifiers, to enhance signal integrity, and a-Si TFT compressive-sensing scanning circuits, to enable reduction of EEG data from many channels onto a single interface, for subsequent processing by a CMOS IC. Further, the system uses an algorithm, by which spectral-energy features, a key EEG biomarker, are extracted directly from the compressed signals. We demonstrate a prototype, performing EEG acquisition from a human subject, and compressed EEG reconstruction and seizure detection via analog replay of patient data. The TFT amplifier achieves a noise PSD of 230 nV/ $\surd $ Hz. Seizure detection, at up to $64\times $ compression, achieves error rates $ 8%. Reconstruction is demonstrated at up to $8\times $ compression.
Cloud Computing for Libraries: The Tech Set #11 by Marshall Breeding

If anyone can or should write a book about cloud computing in libraries, it is the author of this book, who is a well-known library technologist, writer, speaker, and consultant. His thoughtful res...
Directional melting of alumina via polarized microwave heating

Dynamical instabilities and melting of crystals upon heating are fundamental problems in physics and materials science. Using molecular dynamics simulations, we found that drastically different melting temperatures and behaviors can be achieved in α-alumina using microwave heating, where the electric field is aligned with different crystallographic orientations. Namely, alumina melts much earlier at lower temperatures when the electric field is parallel to the c-axis. The atomistic mechanism was identified as selective liberation of the Al sublattice due to the shear instability along the c-axis. This directional melting concept may be used for triggering distinct dynamical instabilities and melting of dielectric crystals using polarized microwave fields.
A Clinical Review of Concentrated Insulins for Type 1 and Type 2 Diabetes Mellitus

Insulin therapy is cornerstone treatment for the management of type 1 diabetes mellitus and often, is initiated for patients with type 2 diabetes inadequately controlled with oral antidiabetic medications or with severe hyperglycemia. Concentrated insulin products are available to address the volume concerns with high doses of insulin U-100 (100 units per milliliter) due to poor or unpredictable absorption. Humulin R U-500 has been available for 20 years, but have been underutilized in clinical practice due to conversions into a U-100 syringe or tuberculin syringe with the vial. Now, its use may increase as a pre-filled pen and U-500 syringe has recently become available. In addition, two additional concentrated insulin were approved in 2015 - insulin glargine U-300 (300 units per milliliter) and insulin degludec U-200 (200 units per milliliter). These specific products are alternative insulin options for type 1 or type 2 diabetes, especially among patients with high doses of insulin therapy and high risk of hypoglycemia. Insulin glargine U-300 and insulin degludec U-200 have similar A1c reduction to active comparators, but have a lower risk of hypoglycemia and nocturnal hypoglycemia. This article evaluates and summarizes the indications, dosing, recent clinical evidence and role of insulin regular U-500, insulin glargine U-300 and insulin degludec U-200 for type 1 and type 2 diabetes mellitus.
Dynamically coded memory effect imaging

The optical memory effect has recently been used to image static scenes through opaque media. By using spatio-temporal coding, we realize memory effect video of dynamic scenes from a single, compressive measurement.
Can upstream biofuel production increase the flow of downstream ecosystem goods and services

Abstract Advanced biomass feedstocks tend to provide more non-fuel ecosystem goods and services (ES) than 1st-generation alternatives. We explore the idea that payment for non-fuel ES could facilitate market penetration of advanced biofuels by closing the profitability gap. As a specific example, we discuss the Mississippi-Atchafalaya River Basin (MARB), where 1st-generation bioenergy feedstocks (e.g., corn-grain) have been integrated into the agricultural landscape. Downstream, the MARB drains to the Gulf of Mexico, where the most-valuable fishery in the US is impacted by annual formation of a large hypoxic “Dead zone.” We suggest that advanced biomass production systems in the MARB can increase and stabilize the provision of ES derived from the coastal and marine ecosystems of the Gulf-of-Mexico. Upstream, we suggest that choosing feedstocks based on their resistance or resilience to disturbance (e.g., perennials, diverse feedstocks) can increase reliability in ES provision over time. Direct feedbacks to incentivize producers of advanced feedstocks are currently lacking. Perhaps a shift from first-generation biofuels to perennial-based fuels and other advanced bioenergy systems (e.g., algal diesel, biogas from animal wastes) can be encouraged by bringing downstream environmental externalities into the market for upstream producers. In future, we can create such feedbacks through payments for ES, but significant research is needed to pave the way.
Impact of nitrogen and importance of silicon on mechanical stem strength in Schoenoplectus acutus and Schoenoplectus californicus : applications for restoration

Nitrogen (N) and Silicon (Si) availability can affect the vigor and resiliency of plant communities. The effects of N on plant growth has been investigated in multiple species and is understood to promote growth. Though it is generally understood that Si aids in plant functions such as stem strength enhancement and herbivory defense, the role Si has not been explored in many wetland plant species. Tidal wetland plants are often subjected to high wind and wave energy, which can cause breakage or collapse of stems. This body of research investigated the combined effects of Si and N regimes to reduce the occurrence of stem collapse through its influence on stem strength. We investigated the effects of Si and N concentration on the growth, morphology, and physiology of Schoenoplectus acutus and Schoenoplectus californicus, two species of macrophytes that are commonly used in freshwater tidal restoration plantings. Individuals of each species were grown hydroponically in four different nutrient combinations (low Si and low N, low Si and high N, high Si and low N, and high Si and high N). Results indicated that increased N concentrations promoted aboveground biomass production, whereas increased Si concentration enhanced stem strength and decreased the likelihood of stem collapse and herbivory. Plants receiving a high Si and low N nutrient combination exhibited the most robust stems. Our findings emphasize the importance of Si, as well as N, in Schoenoplectus spp. growth and highlight the potential applications for these nutrients in enhancing tidal marsh management.
Decreased Lung Function and All-Cause Mortality in HIV-infected Individuals

Rationale: Human immunodeficiency virus (HIV) infection is associated with pulmonary disease and worse lung function, but the relationship of lung function with survival in HIV is unknown.Objective...
A Prospective, Randomized Trial of Splinting After Minicarpal Tunnel Release

Purpose To determine if any significant differences exist in patient-reported or clinical outcomes among 3 different postoperative orthotic regimens: no orthosis, removable orthosis, and plaster nonremovable orthosis—following miniopen carpal tunnel release (CTR) surgery for symptomatic isolated carpal tunnel syndrome. Methods A total of 249 patients received a miniopen CTR and were subsequently randomized into 1 of 3 orthotic regimens: 80, no orthosis; 83, removable orthosis; and 86, nonremovable orthosis—to be removed at the first postoperative visit 10 to 14 days later. Patient-reported outcomes included the quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) surveys, Levine-Katz Symptom Severity and Functional Status Scales, and Pain at Rest and in Action using the Numerical Pain Rating Scale. Clinical outcomes included wrist range of motion, grip, and lateral pinch strengths. All outcomes were evaluated bilaterally at 10 to 14 days, 6 weeks, and 3, 6, and 12 months after surgery by evaluators blinded to the assigned regimen. Demographic information was obtained before surgery, and complications were recorded throughout the study. Results There were no statistically significant differences in any patient-reported or clinical outcomes at any follow-up period except at 6 and 12 months: the lateral pinch strength of the nonremovable orthosis group with CTR in the dominant hand was weaker than both of the other groups. Patient demographic characteristics did not significantly influence the outcomes at any time. Scar tenderness was the most commonly observed complication followed by stiffness. There were 2 cases each of complex regional pain syndrome and superficial wound dehiscence and 1 case of wound infection that resolved with oral antibiotics. Conclusions The postoperative orthotic regimen does not change any patient-reported outcome up to at least 12 months following miniopen CTR. Lateral pinch strength was weaker in the nonremovable orthosis group at 6 and 12 months. Our data do not support the use of any postoperative orthosis following routine miniopen CTR. Type of study/level of evidence Therapeutic I.
Patterns, Predictors, and Outcomes of Postprocedure Delayed Hemorrhage Following Flow Diversion for Intracranial Aneurysm Treatment.

Objective To evaluate patterns, predictors, and outcomes of postprocedure delayed hemorrhage (PPDH) following flow diversion therapy for intracranial aneurysm treatment. Methods From 2012 to 2016, 50 patients with 52 aneurysms were treated with the Pipeline embolization device. Device placement was performed as a standalone therapy or with adjunctive coil embolization. Patients underwent dual antiplatelet therapy for 6 months after treatment. Medical comorbidities; aneurysm traits; and treatment factors, including platelet function testing, were studied. Statistical analysis was performed using cross-tabulation. Results Six PPDHs (12%) occurred 2–16 days (mean 6.8 days) after Pipeline placement, manifesting as 1 of 2 distinct patterns: convexity subarachnoid hemorrhage (cSAH) (n = 4) or lobar intraparenchymal hemorrhage (IPH) (n = 2). All PPDHs occurred ipsilateral to the device; 1 IPH occurred ipsilateral but in a different arterial territory. PPDH occurred in both treated anterior communicating artery aneurysms. Cases of PPDH demonstrated on average lower P2Y12 reaction unit values at the time of treatment. Platelet function testing at the time of hemorrhage was consistently hypertherapeutic. Patients with cSAH had only minimal worsening of modified Rankin Scale score at the time of discharge, whereas the 2 patients with IPH experienced significant deterioration. Conclusions PPDH is a poorly understood complication following flow diversion therapy that can result in significant morbidity. In our experience, nonaneurysmal cSAH does not result in poor clinical outcomes, whereas IPH leads to long-term deficits or death. As previously suggested, there appears to be a correlation between low P2Y12 reaction unit values and PPDH.
Bottom-Up Imaginaries: The Cultural-Technical Practice of Inventing Regional Advantage through IT R&D

Recent HCI research on social creativity and bottom-up innovation has highlighted how concerted efforts by the government policy and business communities to develop innovation ecosystems are increasingly intertwined with IT research and development. We note that many such efforts focus on cultivating regional advantage [20] in the form of innovation hubs that are situated in and leverage distinct sociocultural histories and geographies. Cultivating regional advantage entails achieving broad consensus about what that region's advantage might be, that is, the construction of a regional advantage imaginary beyond the policies, IT supports, and practices to make it happen. Here, we document how an ongoing public debate among makers and manufacturers in Taiwan as a region-distinguished by direct engagement with design, fabrication, prototyping, and manufacturing processes-are proposing pathways toward a regional advantage that both reflects Taiwan's recent sociocultural and economic histories and also its near future aspirations.
Measuring and Manipulating Constitutional Evaluations in the States: Legitimacy Versus Veneration:

American civil religion places the U.S. Constitution on a pedestal. Although this veneration is well-documented, it is unclear where it originates and why other constitutions do not attract the sam...
Proceedings of the 3rd international symposium on Information processing in sensor networks

This volume contains the Proceedings of the 3rd International Symposium on Information Processing in Sensor Networks (IPSN'04). The symposium was held at Berkeley, California, on April 26-27, 2004.Information processing in sensor networks is an interdisciplinary research area with deep connections to signal processing/detection/estimation, networking and protocols, embedded systems, data bases and information management, as well as distributed algorithms. Driven by advances in MEMS micro-sensors, wireless networking, and embedded processing, ad-hoc networks of sensors are becoming increasingly available for commercial and military applications such as environmental monitoring (e.g., traffic, habitat, security), industrial sensing and diagnostics (e.g., factory, appliances), critical infrastructure protection (e.g., power grids, water distribution, waste disposal), and situational awareness for battlefield applications.From the engineering and computing point of view, sensor networks offer a rich source of problems that include sensor tasking and control, tracking and localization, probabilistic reasoning, sensor data fusion, distributed data bases, communication protocols and theory that address network coverage, connectivity, and capacity, as well as system/software architecture and design methodologies. Moreover, in all of these issues there is a need to consider many cross-cutting requirements such as efficiency/cost tradeoffs, robustness, self-organization, fault-tolerance, timeliness, scalability, and network longevity.This symposium takes a systemic approach to address issues from physical device design, to signal processing and from networking to coordination protocols. The Symposium places special attention to revolutionary new applications that are enabled by sensor network technology.Following the success of the first two Workshops that were held at the Palo Alto Research Center in 2001 and 2003, the 3rd International Symposium on Information Processing in Sensor Networks brought together researchers from academia, industry, and government to present and discuss recent work on various aspects of sensor networks such as information organization, querying, routing, and self-organization, with an emphasis on the high-level information processing tasks that these networks are designed to perform.This year 145 papers were submitted to the symposium, about twice as many as last year. Of these papers, 25 were accepted for oral presentation and 25 for poster presentation. Each paper was reviewed by at least three reviewers and on the average by four reviewers. The reviewing process was handled electronically, using the Editor's Assistant (EDAS) software. The final paper selection was made at the technical program committee (TPC) meeting that was held in Chicago with 23 members present. The decisions on oral/poster presentation were based on the topic of the paper, not on technical merit. The program chairs are indebted to the Technical Program Committee members for their efforts in putting together an outstanding technical program.
Magnetic Resonance Imaging Guidance of Radiofrequency Thermal Ablation for Cancer Treatment

Recent trends in the care of cancer patients emphasize minimizing invasiveness while improving the effectiveness of treatment by utilizing medical resources in a cost-effective manner. This has been evident in the emerging and steadily evolving utilization of interventional radiology over the past quarter century.
Propbank Instance Annotation Guidelines Using a Dedicated Editor, Jubilee

This paper gives guidelines of how to annotate Propbank instances using a dedicated editor, Jubilee. Propbank is a corpus in which the arguments of each verb predicate are annotated with their semantic roles in relation to the predicate. Propbank annotation also requires the choice of a sense ID for each predicate. Jubilee facilitates this annotation process by displaying several resources of syntactic and semantic information simultaneously: the syntactic structure of a sentence is displayed in the main frame, the available senses with their corresponding argument structures are displayed in another frame, all available Propbank arguments are displayed for the annotators choice, and example annotations of each sense of the predicate are available to the annotator for viewing. Easy access to each of these resources allows the annotator to quickly absorb and apply the necessary syntactic and semantic information pertinent to each predicate for consistent and efficient annotation. Jubilee has been successfully adapted to many Propbank projects in several universities. The tool runs platform independently, is light enough to run as an X11 application and supports multiple languages such as Arabic, Chinese, English, Hindi and Korean.
Racial and ethnic issues in diet and cancer epidemiology.

This article describes differences in patterns of diet-related cancers among racial and ethnic groups. The objective is to demonstrate the potential insights about the possible role of diet in cancer etiology that might be gained from appropriately designed racial and ethnic comparisons. The examples used relate to racial and ethnic groups within the United States, although the issues are also relevant internationally. A comprehensive consideration of racial/ethnic differences in cancer occurrence from a global perspective has been published elsewhere.1
The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription

Translation and transcription are frequently dysregulated in cancer. These two processes are generally regulated by distinct sets of factors. The CBFB gene, which encodes a transcription factor, has recently emerged as a highly mutated driver in a variety of human cancers including breast cancer. Here we report a noncanonical role of CBFB in translation regulation. RNA immunoprecipitation followed by deep sequencing (RIP-seq) reveals that cytoplasmic CBFB binds to hundreds of transcripts and regulates their translation. CBFB binds to mRNAs via hnRNPK and enhances translation through eIF4B, a general translation initiation factor. Interestingly, the RUNX1 mRNA, which encodes the transcriptional partner of CBFB, is bound and translationally regulated by CBFB. Furthermore, nuclear CBFB/RUNX1 complex transcriptionally represses the oncogenic NOTCH signaling pathway in breast cancer. Thus, our data reveal an unexpected function of CBFB in translation regulation and propose that breast cancer cells evade translation and transcription surveillance simultaneously through downregulating CBFB.
Houston Mosques: Space, Place and Religious Meaning

In thinking about space/power/knowledge intersections, we offer a rich and descriptive account of the urban mosque, which has far too long been neglected. Our account reveals a descriptive language as a basis for aesthetic syncretism and the creation of an American Muslim leitmotif. The leitmotif can be identified as “a thing of space;” therefore, the community “determines its [aesthetic] choices, draws its figures [plans], and [informal] translations. It is in [urban] space that it transports itself” (Crampton and Elden, Space, knowledge and power: Foucault and Geography. Ashgate, Hampshire, 2007). Also Foucault’s Heterotopias helps us to deconstruct the xenophobic commodification of political propaganda, but to address the urban mosque as an American leitmotif we draw the attention to the characteristics of its physical adaption within Houston.
Association Between High School Personality Phenotype and Dementia 54 Years Later in Results From a National US Sample.

Importance Personality phenotype has been associated with subsequent dementia in studies of older adults. However, neuropathologic changes often precede cognitive symptoms by many years and may affect personality itself. Therefore, it is unclear whether supposed dementia-prone personality profiles (high neuroticism and low conscientiousness) are true risk factors or merely reflections of preexisting disease. Objectives To examine whether personality during adolescence—a time when preclinical dementia pathology is unlikely to be present—confers risk of dementia in later life and to test whether associations could be accounted for by health factors in adolescence or differed across socioeconomic status (SES). Design, Setting, and Participants Cohort study in the United States. Participants were members of Project Talent, a national sample of high school students in 1960. Individuals were identified who received a dementia-associatedInternational Classification of Diseases,Ninth Revision(ICD-9) diagnosis code during any year between 2011 and 2013. The dates of our analysis were March 2018 to May 2019. Exposures Ten personality traits were measured by the 150-item Project Talent Personality Inventory. Socioeconomic status was measured by a composite based on parental educational level, income, occupation, and property ownership. Participants were also surveyed on demographic factors and height and weight. Main Outcomes and Measures Medicare records were collected, with dementia diagnoses in the period of 2011 to 2013 classified according to the US Centers for Medicare & Medicaid ServicesICD-9–based algorithm. Cox proportional hazards regression models estimated the relative risk of dementia based on the 10 personality traits, testing interactions with SES and adjusting for demographic confounders. Results The sample of 82 232 participants was 50.1% female, with a mean (SD) age of 15.8 (1.7) years at baseline and 69.5 (1.2) years at follow-up. Lower risk of dementia was associated with higher levels of vigor (hazard ratio for 1 SD, 0.93; 95% CI, 0.90-0.97;P Conclusions and Relevance This study’s findings suggest that the adolescent personality traits associated with later-life dementia are similar to those observed in studies of older persons. Moreover, the reduction in dementia risk associated with a calm and mature adolescent phenotype may be greater at higher levels of SES. Personality phenotype may be a true independent risk factor for dementia by age 70 years, preceding it by almost 5 decades and interacting with adolescent socioeconomic conditions.
Free and conjugated estrogens detections in drainage tiles and wells beneath fields receiving swine manure slurry.

Abstract Although livestock manure, such as from swine (Sus scrofa domestica), have high capacity to introduce endocrine-disrupting free estrogens into the environment, the frequency of estrogen detections from reconnaissance studies suggest that these compounds are ubiquitous in the environment, perhaps resulting from historic manure inputs (e.g. cattle grazing residues, undocumented historic manure applications) or uncontrolled natural sources. Compared to free estrogens, conjugates of estrogens are innocuous but have greater mobility in the environment. Estrogen conjugates can also hydrolyze to re-form the potent free estrogens. The objective of this study was to identify the transport of free and conjugated estrogens to subsurface tile drains and groundwater beneath fields treated with swine manure slurry. Three field treatments were established, two receiving swine lagoon manure slurry and one with none. Manure slurry was injected into soils at a shallow depth (∼8 cm) and water samples from tile drains and shallow wells were sampled periodically for three years. Glucuronide and sulfate conjugates of 17β-estradiol (E2) and estrone (E1) were the only estrogen compounds detected in the tile drains (total detects = 31; 5% detection frequency; conc. range = 3.9–23.1 ng L−1), indicating the important role conjugates played in the mobility of estrogens. Free estrogens and estrogen conjugates were more frequently detected in the wells compared to the tile drains (total detects = 70; 11% detection frequency; conc. range = 4.0–1.6 × 103 ng L−1). No correlations were found between estrogen compound detections and dissolved or colloidal organic carbon (OC) fractions or other water quality parameters. Estrogenic compounds were detected beneath both manure treated and non-treated plots; furthermore, the total potential estrogenic equivalents (i.e. estrogenicity of hydrolyzed conjugates + free estrogens) were similar between treated and non-treated plots.
Survival benefit in patients with peripheral T-cell lymphomas after treatments with novel therapies and clinical trials.

The peripheral T-cell lymphomas (PTCL) are rare and heterogeneous diseases characterized by an unfavorable prognosis. Chemotherapy is standard upfront treatment in most patients, but responses are short-lived with few FDA-approved "novel" agents available. We sought to define the impact of these novel agents as single agents or in clinical trials on the outcomes of patients with PTCL. From January 1994 to May 2019, adult patients with PTCL who were managed at our institution were included in this analysis. In addition to patients with incomplete data, those diagnosed with large granular lymphocytic leukemia and cutaneous T-cell lymphoma (CTCL) except for transformed mycosis fungoides were excluded. Statistical analyses were performed using SAS version 9.4. There were 219 patients included in the analysis. The median age at diagnosis was 56 years (range, 18-90 years). First line therapies mostly consisted of combination chemotherapy (75%). There was a statistical difference among patients who received chemotherapy, novel agents alone and in chemotherapy-free combinations, other, and no treatment (P < .0001). In patients who were treated with second line chemotherapy, novel agents alone and in combination without chemotherapy, or other, there was a still a survival benefit favoring novel agents (P = .0417). In the third line, there was no statistical difference among the three groups (P = .569). All patients who received novel therapies and underwent autologous stem cell transplant (autoSCT) achieved a complete response (CR) and had a better survival compared with patients who underwent chemotherapy who had a 70% CR rate prior to autoSCT (P = .046). Exposure to FDA-approved novel agents, immunoepigenetic trials, and clinical trials in general was associated with an overall survival (OS) benefit (P = .003, P = .04, and P = .006, respectively). These data suggest that patients who receive novel agents have superior outcomes compared with patients without exposure to novel therapies who receive chemotherapy-predicated treatments.
Mechanical characterization of vesicles and cells: A review

Vesicles perform many essential functions in all living organisms. They respond like a transducer to mechanical stress in converting the applied force into mechanical and biological responses. At the same time, both biochemical and biophysical signals influence the vesicular response in bearing mechanical loads. In recent years, liposomes, artificial lipid vesicles, have gained substantial attention from the pharmaceutical industry as a prospective drug carrier which can also serve as an artificial cell-mimetic system. The ability of these vesicles to enter through pores of even smaller size makes them ideal candidates for therapeutic agents to reach the infected sites effectively. Engineering of vesicles with desired mechanical properties that can encapsulate drugs and release as required is the prime challenge in this field. This requirement has led to the modifications of the composition of the bilayer membrane by adding cholesterol, sphingomyelin, etc. In this article, we review the manufacturing and characterization techniques of various artificial/synthetic vesicles. We particularly focus on the electric field-driven characterization techniques to determine different properties of vesicle and its membranes, such as bending rigidity, viscosity, capacitance, conductance, etc., which are indicators of their content and mobility. Similarities and differences between artificial vesicles, natural vesicles, and cells are highlighted throughout the manuscript since most of these artificial vesicles are intended for cell mimetic functions.
Imminence of the Past

Recovering Plato, Aristotle, and Xenophon on tyranny during the Renaissance. Though Aquinas and Giles had the Politics in translation, the text was still truncated and difficult to understand. Oresme rendered it into French under Charles V, King of France (1364–1389); and the Florentine humanist, Ficino, rendered Plato into Latin by 1475; it was printed by Aldus Manutius in 1500. Note that Aristotle’s works were available in Latin earlier than those of Plato. Xenophon’s Hiero was first published in 1516 by the Giunti family of Florence. The learned circle around King Charles V included the first major woman writing about political tyranny: Christine of Pizan.
Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and widespread neuroinflammation. While the cause of AD remains unknown, multiple factors likely contribute to the disease, including heart disease, diabetes, previous head injury, as well as a number of genetic determinants. Inheritance of the apolipoprotein (APOE) e4 allele represents the strongest genetic risk factor for development of AD, driving pathogenesis and increasing overall disease severity. APOE has long been recognized as a key regulator of cholesterol homeostasis, although a greater appreciation now exists for its role in various innate immune system processes. Indeed, APOE modulates inflammatory environments in brain in large part by altering gene expression profiles in glia, important mediators of immunity in the CNS. While the association between APOE and AD was first observed nearly three decades ago, the mechanism by which APOE e4 influences the etiology and pathophysiology of AD is not well characterized. Overwhelming data supports the hypothesis that APOE e4 dysregulates central amyloid metabolism by an undetermined molecular mechanism, thus laying the foundation for disease. A host of amyloid-degrading enzymes (ADEs) regulate Aβ accumulation in brain, and therefore represent valuable therapeutic targets. Neprilysin (NEP), a metalloendopeptidase expressed by activated microglia and astrocytes, is a broad-spectrum ADE able to degrade a variety of Aβ species. Here we describe in vivo and in vitro experiments designed to investigate the potential for APOE genotype to differentially regulate glial NEP in brain under neuroinflammatory conditions. Our results provide a novel mechanism by which APOE genotype-dependent differential expression of NEP by glia during neuroinflammation may contribute to AD pathogenesis.
On the shape of cicada's wing leading-edge cross section.

An important role that the leading-edge cross-section shape plays in the wing flight performance is well known in aeronautics. However, little is known about the shape of the leading-edge cross section of an insect’s wing and its contribution to remarkable qualities of insect flight. In this paper, we reveal, in the first time, the shape of the leading-edge cross section of a cicada’s wing and analyze its variability along the wing. We also identify and quantify similarities in characteristic dimensions of this shape in the wings of three different cicada species.
Artificial Intelligence for radiographic image analysis

Abstract Automated identification of landmarks on lateral cephalogram and cone-beam computed tomography (CBCT) scans can save time for the clinicians and act as a second set of eyes for analysis of radiographic images in diagnosis and treatment planning. Several machine-learning techniques have been utilized for this purpose with varying accuracies. However, high degree of variability in the clinical presentation of orthodontic patients, limitations of the algorithms, lack of labelled data, high compute power, etc. are some drawbacks that have limited robust clinical application of such techniques. In recent years, artificial neural networks like deep learning and more specifically deep neural networks are making significant inroads in the true adoption of this technology. YOLOv3 and Single Shot Multibox Detector are some of the deep learning algorithms that have shown promising results. This paper is a theoretical review of the evolution of these technologies and the current state of the art in orthodontic image analysis.
Megamelus scutellaris (Berg) (Hemiptera: Delphacidae) biology and population dynamics in the highly variable landscape of southern Florida

Abstract Changes to the historical flow and nutrient levels of freshwater bodies in Florida have made control of waterhyacinth difficult. Biological control agents were introduced to augment herbicidal control of this plant. The newest insect agent, Megamelus scutellaris, was released in 2010, has established, and has been documented dispersing more than 6 kms away from release locations, across aquatic and terrestrial habitats. These insects were able to successfully disperse away from herbicide treated areas and across terrestrial habitats to reach new mats of waterhyacinth. Macropterous individuals were the first M. scutellaris documented at three non-release sites, indicating that the established wild populations are producing flighted individuals and are dispersing actively. Established populations appear to have reached an equilibrium density of 10.74 ± 19.74 M. scutellaris/m2 and this does not fluctuate with additional releases.