cssi/SciSciGPT-SciSciNet huggingface dataset:
Slowly growing, ulcerating nodule on the posterior ankle .

﻿﻿﻿﻿﻿﻿﻿﻿﻿﻿A 34-year-old Haitian man presented with a 1-year history of a gradually en- larging, ulcerating nodule on the right posterior ankle that bled after trauma. The patient denied any history of prior trauma at the site of the lesion and foreign travel.There were no HIV risk factors or personal or family history of skin cancer.The patient was otherwise healthy with no additional complaints. Physical examination revealed a 1.4 cm firm, hyperpigmented nodule with a yellow crateriform center on the right posterior ankle (Figure 1).A punch biopsy was performed (Figures 2, 3). Histopathologic examination revealed a superficial and mid-dermal, multi- nodular proliferation of bland epithelioid cells with occasional foci of ductal differentiation embedded in a fibrotic stroma. Focal epidermal connection and mucinous metaplasia were noted. Immunohistochemical stains revealed diffuse positive staining of the lesional cells with cytokeratins (high and low) and variable positivity with epithelial membrane antigen (EMA), as well as negative S100P. Fungal, viral, and mycobacterial tissue cultures were negative and RPR was non-reactive. Bacterial tissue culture was positive for Prevotella oris and Staphylococcus aureus.
Electron-microscopic studies on a double-stranded beaded filament of embryonic collagen.

Beaded filaments consisting of paired 40-A strands in parallel coupled by 150-A beads at periodic spacings of 640 A have been isolated from embryonic pig dermis. These filaments are found in association with embryonic collagenous fibrils and exclusively at sites of active fibrillogenesis of collagen. They have been identified within sectioned native fibrils as well as in interfibrillar regions. Furthermore, they have been recovered from fibrils denatured by exposure to alkalinity or to heat. In those instances, the filaments are packed in parallel array and the component beads are registered to produce a banding pattern with a major 640 A repeat. The strands of the complex are composed of non-rigid fibrous protein as deduced from their fixation with aldehyde fixatives and from their degradation by urea. The beads are also proteinaceous, as indicated by their susceptibility to tryptic digestion. Moreover, these beads contain lipid, since they stain with lipid stains and dissolve in lipid solvents. Additional evidence suggests the inclusion of polysaccharide in the beads: periodic acid destroys these structures, and in native fibrils silver staining for carbohydrate occurs at loci of registered beads. The structural integrity of the conjugated protein bead does not depend upon the lipid or polysaccharide components, since lipases or β -amylase do not digest the structures. The filament proper is collagenase-resistant, but trypsin-sensitive. The latter enzyme bisects the beaded filament, forming single-stranded filaments with alternating 640-A and 200-A segments between beads. The double-stranded filaments are soluble in acid solutions below pH 4 but are stable at higher pH9s through 9-10. The beaded filament fits into the scheme of extracellular collagen fibrillogenesis as the primary stable fibril or protofibril of collagen. It is presented as a doublet of procollagen fibrils which serves as a template for the polymerization of tropocollagen into additional beaded filaments. Aligned in parallel array and in register as they are assembled, the aggregate of beaded filaments is built into an immature fibril. By the establishment of interfilamentous cross-links, the individuality of the beaded filament is lost within the progressively maturing fibril.
The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis.

Summary In Arabidopsis, the C-repeat binding factors (CBFs) have been extensively studied as key transcription factors in the cold stress response. However, their exact functions in the cold response remains unclear due to the lack of a null cbf triple mutant. In this study, we used CRISPR/Cas9 technology to mutate CBF1 or CBF1/CBF2 in a cbf3 T-DNA insertion mutant to generate cbf1,3 double and cbf1 cbf2 cbf3 (cbfs) triple mutants. The response of the cbfs triple mutants to chilling stress is impaired. Furthermore, no significant difference in freezing tolerance was observed between the wild-type and the cbf1,3 and cbfs mutants without cold acclimation. However, the cbfs mutants were extremely sensitive to freezing stress after cold acclimation, and freezing sensitivity ranking was cbfs > cbf1,3 > cbf3. RNA-Seq analysis showed that 134 genes were CBF regulated, of which 112 were regulated positively and 22 negatively by CBFs. Our study reveals the essential functions of CBFs in chilling stress response and cold acclimation, as well as defines a set of genes as CBF regulon. It also provides materials for the genetic dissection of components in CBF-dependent cold signaling.
Kerensky as Napoleon (April-June 1917)

Kerensky was the first leader of the Russian Revolution who evoked the images of Napoleon’s regime. That these images were associated, indirectly or directly, with Kerensky indicates clearly that the idea of Napoleonic coup was in the air and that society was moving away from the romantic ‘false consciousness’ generated by the excitement of the first months of the revolution to ‘true consciousness’, that is, the assumption that a right-wing dictatorship similar to Napoleon’s was at hand.
Diasporizing the Digital Humanities: Displacing the Center and Periphery

The field of digital humanities has expanded in recent years to encompass a range of practices and practitioners around the world and has changed the nature of scholarly communication. So too have emerged centers and peripheries of the field that privilege scholarly production of the United States, the United Kingdom, and Canada. This article examines efforts to challenge the hierarchical dimensions of power, making the case for viewing transnational scholarly networks through a logic of diaspora.
Structure and mechanical implications of the pectoral fin skeleton in the Longnose Skate (Chondrichthyes, Batoidea)

Abstract Animal propulsion systems are believed to show high energy and mechanical efficiency in assisting movement compared to artificial designs. As an example, batoid fishes have very light cartilaginous skeletons that facilitate their elegant swimming via enlarged wing-like pectoral fins. The aim of this work is to illustrate the hierarchical structure of the pectoral fin of a representative batoid, the Longnose Skate (Raja rhina), and explain the mechanical implications of its structural design. At the macro level, the pectoral fins are comprised of radially oriented fin rays, formed by staggered mineralized skeletal elements stacked end-to-end. At the micro level, the midsection of each radial element is composed of three mineralized components, which consist of discrete segments (tesserae) that are mineralized cartilage and embedded in unmineralized cartilage. The radial elements are wrapped with aligned, unmineralized collagen fibers. This is the first report of the detailed structure of the ray elements, including the observation of a 3-chain mineralized tesserae. Structural analyses demonstrate that this configuration enhances stiffness in multiple directions. A two-dimensional numerical model based on the morphological analysis demonstrated that the tessera structure helps distributing shear, tensile and compressive stress more ideally, which can better support both lift and thrust forces when swimming without losing flexibility. Statement of Significance Batoid fishes have very light cartilaginous skeletons that facilitate their elegant swimming by applying their enlarged wing-like pectoral fins. Previous studies have shown structural features and mechanical properties of the mineralized cartilage skeleton in various batoid fishes. However, the details of the pectoral fin structure at different length scales, as well as the relationship between the mechanical properties and structural design remains unknown. The present work illustrates the hierarchical structure of the pectoral fin of the Longnose Skate (a representative batoid fish) and verifies the materials configuration and structural design increases the stiffness of fin skeleton without a loss in flexibility. These results have implications for the design of strong but flexible materials and bio-inspired autonomous underwater vehicles (AUVs).
And Akt-ion! IQGAP1 in control of signaling pathways.

ERK signaling and Akt signaling are inversely correlated in some cancers. Yet, the precise molecular mechanism for cross‐inhibition remains unclear. In this issue of The EMBO Journal , Pan et al ([2017][1]) show that when Akt is on, its phosphorylated cytoplasmic substrate FOXO1 turns off ERK activity by reshaping the Ras‐ERK scaffold IQGAP1. [1]: #ref-8
Is meiosis a fundamental cause of inviability among sexual and asexual plants and animals

Differences in viability between asexually and sexually generated offspring strongly influence the selective advantage and therefore the prevalence of sexual reproduction (sex). However, no general principle predicts when sexual offspring will be more viable than asexual offspring. We hypothesize that when any kind of reproduction is based on a more complex cellular process, it will encompass more potential failure points, and therefore lower offspring viability. Asexual reproduction (asex) can be simpler than sex, when offspring are generated using only mitosis. However, when asex includes meiosis and meiotic restitution, gamete production is more complex than in sex. We test our hypothesis by comparing the viability of asexual and closely related sexual offspring across a wide range of plants and animals, and demonstrate that meiotic asex does result in lower viability than sex; without meiosis, asex is mechanistically simple and provides higher viability than sex. This phylogenetically robust pattern is supported in 42 of 44 comparisons drawn from diverse plants and animals, and is not explained by the other variables included in our model. Other mechanisms may impact viability, such as effects of reproductive mode on heterozygosity and subsequent viability, but we propose the complexity of cellular processes of reproduction, particularly meiosis, as a fundamental cause of early developmental failure and mortality. Meiosis, the leading cause of inviability in humans, emerges as a likely explanation of offspring inviability among diverse eukaryotes.
Engaging oncologists toward integrating a shared mental model for palliative oncology within a large academic oncology practice.

105Background: We aimed to engage oncologists to disseminate a successful pilot-tested shared mental model (SMM) for the integration of early advance care planning (ACP) and identification of palli...
Taming Uncivil Discourse: Does Reappropriating Group Insults Work?

In an era of increasingly intense populist politics, a variety of issues of intergroup prejudice, discrimination, and conflict have moved center stage in American politics. Among these is “political correctness” and, in particular, what constitutes a legitimate discourse of political conflict and opposition. Yet the meaning of legitimate discourse is being turned on its head as some disparaged groups seek to reclaim, or reappropriate, the slurs directed against them. Using a Supreme Court decision about whether “The Slants” – a band named after a traditional slur against Asians – can trademark its name, we test several hypotheses about reappropriation processes, based on a nationally representative sample with an oversample of Asian-Americans and several survey experiments. In general, we find that contextual factors influence how people understand and evaluate potentially disparaging words, and we suggest that the political discourse of intergroup relations in the U.S. has become more complicated by processes of reappropriation.
Applying advanced analytics to guide emergency department operational decisions: A proof-of-concept study examining the effects of boarding.

Abstract Background Emergency Department (ED) leaders are increasingly confronted with large amounts of data with the potential to inform and guide operational decisions. Routine use of advanced analytic methods may provide additional insights. Objectives To examine the practical application of available advanced analytic methods to guide operational decision making around patient boarding. Methods Retrospective analysis of the effect of boarding on ED operational metrics from a single site between 1/2015 and 1/2017. Times series were visualized through decompositional techniques accounting for seasonal trends, to determine the effect of boarding on ED performance metrics and to determine the impact of boarding “shocks” to the system on operational metrics over several days. Results There were 226,461 visits with the mean (IQR) number of visits per day was 273 (258–291). Decomposition of the boarding count time series illustrated an upward trend in the last 2–3 quarters as well as clear seasonal components. All performance metrics were significantly impacted (p Conclusion In this study regarding the use of advanced analytics in daily ED operations, time series analysis provided multiple useful insights into boarding and its impact on performance metrics.
Skin Commensal Antigens: Taking the Road Less Traveled

Although our knowledge of host–commensal interactions has increased exponentially, the mechanisms linking a specific commensal, its detection by the immune system, and its impact on tissue function are still often poorly understood. In a recent study in Cell, Linehan et al. dissect one of these interactions in the context of the skin, and demonstrate that Staphylococcus epidermidis antigens, presented through a non-classical pathway, drive the accumulation of CD8+ T cells that promote wound healing.
Live and Let Live: Africa’s Response Options to China’s BRI

In Chap. 9, Kodzi offers a timely perspective on the ongoing debate about how China’s BRI might deliver tangible benefits to African partners. The impact of Chinese engagement on local businesses in different regions is explored both broadly and in a specific African country context. Using the resource dependence theory and the supply chain practice view, the chapter focuses on technology- and knowledge-enhancing industry linkages to conceptualize a pragmatic response by African industry sectors to the competitive pressures associated with Chinese business engagement. By adopting a response view, this chapter proposes credible options for African countries to increase the strategic value of their contribution in BRI exchanges—rather than being casualties of power asymmetry.
A Multidisciplinary Framework For Resilence To Disasters And Disruptions

System resilience is the ability of organizational, hardware and software systems to mitigate the severity and likelihood of failures or losses, to adapt to changing conditions, and to respond appropriately after the fact. Challenger, Columbia, Chernobyl and Bhopal are examples of such failures. System resilience goes beyond traditional disciplines, such as reliability and system safety to achieve its goal. System resilience requires that technical and managerial processes be executed as a unified whole. System resilience employs the systems approach at product and infrastructure levels. The infrastructure system includes such nodes as the developer, the customer, the user, the maintainer, and the operator. System resilience requires that systems engineering principles be practiced across organizational boundaries and to a greater level of detail than is common in today's world. System resilience incorporates the principles of organizational psychology to develop beneficial paradigms within all nodes of the infrastructure. The combination of capabilities, culture and infrastructure forms the basic framework of system resilience. A key aspect of catastrophes is emergence, that is, characteristics of a system that cannot be predicted from the characteristics of the components. Sometimes emergence results from the negative interaction among two or more elements of the system, which, when acting alone, perform benignly. While positive, or desirable, emergence is widely studied, negative, or undesirable, emergence is of interest in the study of resilience. Prediction of emergence and design of adaptive systems that will survive emergent events is a major challenge of resilience. Adaptability, agility and robustness are the characteristics of a system that allow it to survive a disruption. Although the principles of adaptability, agility and robustness have been formulated and shown to reflect the characteristics of systems that have survived disruption, the actual implementation of them lie largely in the heuristics of systems architecting.
Phase-Locked Loops

In this chapter we describe an important electronic circuit, the phase-locked loop (PLL). We first investigate the circuit’s dynamics without and with random perturbations, but in the absence of external forcing. Then we analyze the response of the circuit to noisy external signals, and we describe a method for extracting signals from the result.
Abstract 3130: Immune profiling in uterine papillary serous carcinoma cancer patients reveals distinct subpopulations and clinical outcomes

Uterine papillary serous carcinoma (UPSC) is a rare but aggressive type of endometrial cancer (EC) that represents 10% of cases of EC but accounts for 40% of EC deaths. Patients with UPSC have poor survival rates, a high risk of recurrence and frequently metastasize to the lymph nodes and the omentum. The mechanisms that drive UPSC progression have not been elucidated yet and immune profiling can be a valuable tool to understand the different patient outcomes. In this work, we used formalin fixed paraffin embedded (FFPE) tumor samples from a cohort of 140 patients with UPSC, the largest used to date, to study a panel of 7 immune markers by multiplex immunofluorescence, using the OpalTM system (Perkin Elmer) in the same tissue section. Samples were imaged with Vectra 3.0 multispectral microscope (Perkin Elmer) and images were analyzed using Visiopharm software. Tumor samples from primary, metastatic and recurrent sites were used to study the tumor microenvironment. We observed significant differences in the tumor-infiltrating immune cells between patients that recurred and those that did not. Similarly, immune subpopulations distinguished patients with metastasis compared to those with a less aggressive form of UPSC. Spatial distribution of cytotoxic T cells (CD8+ GranzymeB+) and cancer cells was also found to significantly correlate with overall patient survival. Collectively, our work shows the immune populations play a role in patient outcomes and should be taken into account for future therapeutic strategies. Citation Format: Angela Rynne Vidal, Karen H. Lu, Samuel C. Mok. Immune profiling in uterine papillary serous carcinoma cancer patients reveals distinct subpopulations and clinical outcomes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 3130.
CAR T cells find strength in polyfunction.

In this issue of Blood , Rossi et al report that the heterogeneity of personalized chimeric antigen receptor (CAR) T cells has limited the ability to identify product attributes that enhance patient outcomes, but they have showed that by using single-cell analyses, heterogeneity may actually improve clinical outcomes. 1
Patient perceptions of chlorhexidine bathing: A pilot study using the health belief model.

Background Many studies investigating daily chlorhexidine gluconate (CHG) bathing as an infection control intervention to decrease health care–associated infections have focused on reduction of infection and colonization; few studies have assessed CHG bathing compliance, work system factors, facilitators, and barriers to implementation. Methods This is a combination retrospective/prospective pilot study conducted at a large academic teaching hospital that implemented daily CHG bathing across all inpatient units. CHG compliance and patient refusal were calculated on the basis of documentation in the electronic medical record. We used the health belief model to guide semistructured interviews with patients about knowledge and barriers related to CHG bathing. Results Of the 31 patients interviewed, 74% reported using CHG soap during their stay. Average compliance documented in the electronic medical record was 78% with a range of 57%-91% among all hospital units. Sixteen percent of patients declined CHG bathing, and refusal ranged from 3%-29% among all units. Major themes about CHG bathing from patient interviews include low perceived susceptibility to infection, high degree of trust in medical professionals, low knowledge of benefits of CHG, and low perceived self-efficacy in preventing HAIs. Conclusions Educating patients about CHG bathing appears to be a critical factor in decreasing patient refusal of CHG bathing.
Nanostructure for near total light absorption in a monolayer of graphene in the visible

We propose a highly compact structure for near total light absorption in a monolayer of graphene in the visible. The structure consists of a grating slab covered with the graphene monolayer. The grating slab is separated from a metallic back reflector by a dielectric spacer. The structure supports a guided resonance in the visible. We show that such a structure enhances light–matter interactions in graphene via critical coupling by matching the external leakage rate of the guided resonance and the intrinsic loss rate in the system. We also show that, by using the dielectric spacer between the grating and the metallic mirror, near total absorption in the graphene monolayer can be achieved in the visible without the need for thick multilayer dielectric mirrors. The proposed structure could find applications in the design of efficient nanoscale visible-light photodetectors and modulators.
Development of a tablet app designed to improve African Americans’ screening colonoscopy rates

Compared with other racial/ethnic groups, African Americans have the highest colorectal cancer (CRC) morbidity and mortality rates. It is critical to help improve African Americans' CRC prevention efforts in order to reduce the burden of CRC in this community. The aim of this study was to develop and field test a tablet app, called e-Motivate, designed to improve African Americans' screening colonoscopy rates. The e-Motivate app was field tested, using an iterative approach. The first version of the app, e-Motivate 1.0, was field tested on 20 African Americans over the age of 50. Participants engaged in a think aloud exercise and provided feedback regarding the app's usability and acceptability. The results of the first field test were used to modify the app and develop e-Motivate 2.0. The field test procedures were repeated on a new group of participants (N = 18). The results from the second field test were used to make final modifications to the app. Overall, participants responded positively to the app. Qualitative analyses showed that participants found the app to be easy to use and helpful. Furthermore, descriptive statistics revealed that participants found the app to be highly usable and acceptable, exceeding recommended benchmarks for usability and acceptability. Critiques of the app were used to modify and finalize the intervention. The results from the proposed study suggest that the e-Motivate app is highly feasible and acceptable. The next step in this line of research is to conduct a randomized clinical trial to formally test the efficacy of the e-Motivate app for improving screening colonoscopy rates among African Americans.
Перспективы финансирования проектов инфраструктуры: инвестиции, взаимодействие и доверие в межкультурном контексте

Project fnance of infrastructure (e.g. exploitation and transportation of natural resources, high speed railways, internet) forms a basis for the peaceful development and the prosperity of nations as well as the transnational community. What is needed are dependable networks in a world in transition, where digitalisation and new powers demand joint action. Particularly in the Eurasian region, from Lisbon to Vladivostok, felds with future prospects are opening up for Russia, Germany and the European union. We can develop them through investment and cooperation, by building up trust through common rules and sustainable substance. Here, a concept for this is presented for “Intercultural Project Finance”: An order of law and business (order of assets; German: Vermoegensordnung), in which state and private actors build up the necessary trust and are able to co-operate and proft transnationally for the good of the common prosperity of all peoples. A key element of a suitable system for the investment of capital (transnational investor protection law) is a sustainable valuation law; this has to be developed and etablished by legal comparison. In the following, relevant aspects for theory and practice which are basic for the actors of infrastructure project fnance will be shown, as well as the new initiative of the European union regarding “Connectivity”.
Emulation and Empowerment: Material, Social, and Economic Dynamics in Eighteenth- and Nineteenth-Century Virginia

The influence of emulative behavior on the material and socioeconomic transformations of the eighteenth- and nineteenth-century Anglo-American world is widely debated. A study of historical archaeological sites and probate inventories in Virginia implicates emulation as one ethic operative in rural communities but also identifies a second dynamic: a tendency for many planters of divergent means to act in step with one another, responding in similar ways to new circumstances. Here termed a “cultural accord,” this affinity enabled some individuals who occupied middling social positions to use emulation advantageously in ways that less privileged members of the population could not.
A Slow Algorithm Improves Users' Assessments of the Algorithm's Accuracy

With computational algorithms making an increasing number of deeply consequential, and often problematic judgments on our behalf, there is a growing interest in slowing down technology to encourage users to reflect on judgments made by algorithms. Prior work in slow technology has established slowness as an agent of reflection and serendipity; however, it has been unclear whether this waiting time actually helps users gain useful insight or any other benefits as they make judgments using an algorithm. To this end, we conducted a series of online and in-person between-subject user studies in which we isolate the impact of an algorithm's speed on how users incorporate the algorithm's advice when making judgments in the context of simple visual recognition tasks. We find that our participants followed good quality algorithms more and bad quality algorithms somewhat less if the response time of the algorithm is slower. Furthermore, qualitative analysis of the in-person study interviews reveals that the waiting was not time wasted, but was often used to reflect on the task and the estimation process of themselves and the algorithm, and to compare and reevaluate the two processes. Based on these findings, we outline design implications of future algorithmic systems.
The exercise cytokine interleukin 15 rescues slow wound healing in aged mice

Impaired wound healing in elderly individuals increases infection risk and prolongs surgical recovery, but current treatment options are limited. Low doses of interleukin-15 (IL-15) that mimic exercise responses in the circulation improve skin structure and increase mitochondria in uninjured aged skin, suggesting that IL-15 is an essential mitochondrial signal for healing that is lost during aging. Here we used gene microarray analysis of old and young murine epidermal stem cells and demonstrate that aging results in a gene signature characteristic of bioenergetic dysfunction. Intravenous IL-15 treatment rescued chronological aging-induced healing defects and restored youthful wound closure in old, sedentary mice. Additionally, exercise-mediated improvements in the healing of aged skin depend upon circulating IL-15. We show that IL-15 induces signal transducer and activator of transcription 3 (STAT3) signaling characteristic of young animals, reduces markers of growth arrest, and increases keratinocyte and fibroblast growth. Moreover, exercise or exercise-mimicking IL-15 treatment rescued the age-associated decrease in epidermal mitochondrial complex IV activity. Overall, these results indicate that IL-15 or its analogs represent promising therapies for treating impaired wound healing in elderly patients.
Response to Comment on "Truncated IV acetylcysteine treatment duration has potential to safely preserve resources during the COVID-19 pandemic".

Dear Editor,The response offered by Dr Wong is well taken. A thoughtful discussion regarding the practical application of a truncated acetylcysteine regimen is certainly warranted prior to its univ...
Incremental Intervention Effects in Studies with Dropout and Many Timepoints

Modern longitudinal studies collect feature data at many timepoints, often of the same order of sample size. Such studies are typically affected by {dropout} and positivity violations. We tackle these problems by generalizing effects of recent incremental interventions (which shift propensity scores rather than set treatment values deterministically) to accommodate multiple outcomes and subject dropout. We give an identifying expression for incremental effects when dropout is conditionally ignorable (without requiring treatment positivity), and derive the nonparametric efficiency bound for estimating such effects. Then we present efficient nonparametric estimators, showing that they converge at fast parametric rates and yield uniform inferential guarantees, even when nuisance functions are estimated flexibly at slower rates. We also study the efficiency of incremental effects relative to more conventional deterministic effects in a novel infinite time horizon setting, where the number of timepoints can grow with sample size, and show that incremental effects yield near-exponential gains in this setup. Finally we conclude with simulations and apply our methods in a study of the effect of low-dose aspirin on pregnancy outcomes.
Transformative tourism: Tourists' drawings, symbols, and narratives of change

Abstract Using the theoretical lens of Interaction Ritual Chains theory, the study investigates how transformative tourism narratives are symbolized by transformed tourists. Transformative tourism focuses on pushing tourists out of their comfort zone, encouraging inclusive worldviews, promoting cross-cultural understanding and social empowerment. A creative qualitative multi-method approach is utilized where transformed tourists draw, answer sentence completions, participate in in-depth interviews, and interpret the symbols associated with their transformative narratives. Those narratives can be used by practitioners to market the unique nature of transformative tourism by using symbols that resonate with prospective transformative tourists and aligns with their desire to travel in a way that positively benefits destination residents.
Substation Decision-making Platform Based on Artificial Intelligence

In view of the actual needs faced by the substation maintenance, this paper proposes a kind of substation decision-making platform based on artificial intelligence. The platform formalizes and integrates the basic data, electrical data and the operational data of the equipment, qualitatively triggers the maintenance task abide by the result of the logistic regression model, provides further results of data processing through quantitative analysis, and provides knowledge navigation to the operation guidance of the corresponding equipment. The platform matches the electrical data with the inference engine stored in the knowledge base. If the data match the condition of the inference successfully, the inference is triggered and the action is executed. The result is provided to the relevant staff as a suggestion to assist the final decision. After the task is completed, the cause, effect and solution of the equipment failure are backfilled and expanded into the equipment base as a new instance.
Statistical Bounded Age-Of-Information for mURLLC Over 6G Multimedia Wireless Networks

Massive ultra-reliable and low-latency communication (mURLLC) in the sixth generation (6G) wireless networks aims at providing a wide range of delay-sensitive real-time services and applications for massive accessing by satisfying users' stringent requirements on the delay-bound and error rate. The age of information (AoI) theory characterizes the freshness of information, which measures the time-difference between the current time and the time-stamp of the latest observation, and thus, has been recognized to be able to analyze the mURLLC information transmission latency. How to statistically upperbound the AoI is critically important, because the 6G mURLLC mobile users are served by time-varying wireless channel and the deterministic upper-bounded AoI is difficult to guarantee. To overcome this challenge, in this paper we propose and develop the analytical modeling techniques to identify and characterize the statistical-bounded-AoI theory to efficiently support mURLLC services over 6G mobile wireless networks. First, we introduce the θ-envelope rate of the maximum AoI (i.e. peak AoI) to represent the envelope's average changing rate for the stochastic sequence of the maximum AoI. Then, we derive the upper-bound and lower-bound on the distribution of the maximum AoI. Third, we define and model the statistical-bounded AoI by developing the AoI-exponent to measure the exponential decaying rate of the AoI violation probability. Finally, we validate and evaluate our derived results of the AoI evolution in mURLLC networks through numerical analyses.
The Computational Structure of Programs and the Universe

I’ll talk about my emerging new foundational understanding of computation based on three large-scale projects: (1) Our recent Physics Project, which provides a fundamentally computational model for the low-level operation of our universe, (2) My long-time investigation of the typical behavior of simple programs (such as cellular automata, combinators, etc.) in the computational universe and (3) The long-time development of the Wolfram Language as a computational language to describe the world. I’ll describe my emerging concept of the multicomputational paradigm—and some of its implications for science, distributed computing, language design and the foundations of computation and mathematics.
The effect of orthotics on intersegmental foot kinematics and the EMG activity of select lower leg muscles.

Abstract Background Persons with exertional related leg pain are managed using orthoses. This study aimed to determine the effectiveness of two orthoses in altering foot motion and muscle activity in symptomatic individuals. Methods 52 subjects with lower extremity pain complaints of a non-traumatic, mechanical origin received one of two orthoses. Foot kinematics and EMG activity were recorded while treadmill walking in 3 footwear conditions. The peak EMG activity of the sandal and sandal orthotic trials (normalized to peak barefoot values) and foot motion during 4 subphases of stance were obtained. Using a multivariate multilevel model via linear mixed models, the effect of orthoses within these phases on motion and EMG was determined. Results An effect of orthotic type was not present for any of the rearfoot or forefoot motions ( p >.10). A significant effect of footwear and orthotic type on first ray motion ( p p =.036) was present. Conclusion Orthoses are unable to control rear or midfoot motion but appear to control first ray motion and during late stance, affect tibialis posterior muscle activity. Public trials registry number: NCRT02143947.
SOME VEHICLE FACTORS RELATED TO TYPE AND SEVERITY OF PEDESTRIAN INJURIES

About 8,000 pedestrians are killed each year in the United States and probably another 180,000 are injured. This paper reports on an analysis of 1978 and 1979 New York pedestrian accidents to try to find any relationships between vehicle factors and pedestrian injury severity and location. In these data trucks and vans were found to be associated with more severe pedestrian injuries than passenger cars. However, within the passenger car category vehicle weight and injury severity were not clearly related. And few meaningful relationships were found between aspects of the passenger car front end configuration or the past production use of "soft" materials and pedestrian injury severity of location.
Art in Institutions: The Emergence of (Disabled) Outsiders.

In this article, we use a disability studies lens to examine ways in which the artworks of disabled people1 are bonded in a common sociopolitical experience. We analyze the history surrounding institutional art and the emergence of community art centers at the time of deinstitutionalization in the late 20th century. As a result of this synchronicity, art centers were able to offer the Arts as a means of communication, as well as to assist disabled people in making smooth transitions into their communities. We suggest that the innovative communication techniques developed in these centers could be adopted within all art programs and inclusive classrooms that serve severely disabled students, particularly learners with communication impairments. The article presents the House of Artists, The Community Growth Art Center, and the Grass Roots Art and Community Effort as strong examples of art education sites that transcend traditional “outsider” stereotypes by diligently striving to understand how and what dis...
Facing disability with resources from Aristotle and Nietzsche.

Suddenly unable to walk, I found resources for facing disability in the works of Aristotle and Nietzsche, even though their respective ethical schemes are incommensurable. Implementing Amelie Rorty's notion of crop rotation, I show how each scheme offers the patient something quite indispensable, having to do with how each has its own judgmentally-motivated psychological underpinnings. Aristotle's notion of empathy, wherein the moral move occurs whenever we take up someone else's good as our own, is empowering, especially to those who face an imperiled embodiment. However, Nietzsche teaches us that pity is demeaning both to the pitier and to the pitied, because it falsely assumes that life should be easy so that we are filled with ressentiment when it isn't. Those facing disability need empathy, not pity. The richness of this distinction is vividly conveyed in narratives that show how empathy and pity play out in lived situations, thereby avoiding the dissociation that too often characterizes ethical theorizing. By honoring narrative accounts of how these relational moves are either snagged or successfully made, the attuned moral agency of medical practitioners can be fostered.
Sentinel lymph node biopsies in cancers of the skin, colon, head and neck, and breast.

The sentinel lymph node (SLN) is the initial site of lymphatic drainage for a tumor. Biopsy of the SLN is accurate in predicting the status of the lymph node basin because cells progress from the tumor to the node in a sequential pattern. Patients whose SLN shows no signs of disease can be spared the morbidity of further node dissection. The focus is on a single lymph node, possibly two, depending on the biopsy. The procedure is safe, minimally invasive, cost effective, and can be used in melanoma, colon cancer, head and neck cancer, and breast cancer.
On the Appeal to a Pre-Established Harmony Between Pure Mathematics and Relativity Physics

Soon after its appearance in 1905, the Einsteinian relativity with its relativistically admissible 3-velocities was recognized by Vladimir Varicak in 1908 as the realization in physics of the hyperbolic geometry of Bolyai and Lobachevski. At the same time, however, during the years 1907–1909 Minkowski reformulated the Einsteinian relativity in terms of a space of 4-velocities that now bears his name. As a result, the special theory of relativity that we find in the mainstream literature is not the one originally formulated by Einstein but, rather, the one reformulated by Minkowski. Thus, in particular, one of the most powerful ideas of Einstein in 1905, the Einstein addition of relativistically admissible 3-velocities that need not be parallel, is unheard of in most texts on relativity physics. Following our recently published book, Beyond the Einstein Addition, Law and its Gyroscopic Thomas Precession: The Theory of Gyrogroups and Gyrovector Spaces [1], the aim of this article is to employ the principle of pre-established harmony between mathematics and physics to demonstrate that the original Einsteinian relativity, as opposed to the Minkowskian relativity, is the legitimate formulation of special relativity whose time has returned.
Effect of epidural and intravenous use of the neurokinin-1 (NK-1) receptor antagonist maropitant on the sevoflurane minimum alveolar concentration (MAC) in dogs

Abstract Objective To determine the effect of maropitant, an NK-1 receptor antagonist on the minimum alveolar concentration (MAC) of sevoflurane after intravenous and epidural administration to dogs. Study design Prospective experimental study. Animals Seven, adult, spayed-female dogs (24.8 ± 1.9 kg). Methods Each dog was anesthetized twice with sevoflurane in oxygen, with at least 10 days separating the anesthetic events. The minimum alveolar concentration (MAC) of sevoflurane was determined using the tail-clamp technique. During the first anesthetic event, the MAC of sevoflurane was determined initially and again after intravenous administration of maropitant (5 mg kg−1) and an infusion (150 μg kg−1 hour−1). During the second anesthetic event, an epidural catheter was advanced to the 4th lumbar vertebra and MAC was determined after administration of saline and maropitant (1 mg kg−1) epidurally. All MAC determinations were done in duplicate. The MAC values were adjusted to sea level and compared using student's t-test. Results The baseline MAC for sevoflurane was 2.08 ± 0.25%. Intravenous maropitant decreased (p 0.05) the MAC (2.17 ± 0.34% and 1.92 ± 0.12%, respectively). Conclusion and clinical relevance Maropitant decreased the MAC of sevoflurane when administered intravenously to dogs but not after epidural administration.
A framework for evaluating policy adjustment programs: Lessons from a cross‐country evaluation

This paper presents a macroeconomic framework for evaluating the effects of policy-based adjustment programs with an illustration from a recent World Bank structural and sectoral adjustment lending evaluation and offers guidelines on the design of conditionality. The framework is designed for situations in which an estimated model of the economy is not available. It is basically a version of Robert Mundells policy assignment model which assigns policy instruments to targets following the principle of comparative advantage. The paper focuses on a cross-country application of the framework and begins with a discussion of the assignment model. The example which draws from World Bank experience in adjustment lending in 55 countries strongly indicates that when a macro framework is introduced early in the design of an economic adjustment program and decisions on policy are guided by the framework the policy instruments are more likely to have their intended impact and their results are more likely to be sustainable. This paper also includes a general discussion on the design of adjustment programs including a section on the structure of loan conditionalities.
Introduced Infections of Viral Disease in Populations of Citrus Red Mites

Large and small populations of Panonychus citri (McGregor) in orange groves were sprayed with the noninelusion virus of this mite applied as a suspension of 0.01% triturated diseased mites, or exposed to infected mites collected in the field. The infection established via the released mites was effective in suppressing large populations but was ineffective in small populations. The stress density dependent.
The helping hand strikes again unintended consequences of child abuse reporting

Concomitant with the evolution of a humane philosophy of intervention in the first decade after the medical discovery of child abuse in the 1960's came a broadening of the definition of the problem. The assumptions of low frequency, the benevolent role for government, and the competency of child welfare programs must be challenged in light of present data, values, and experience. The promise implicit in the child abuse reporting laws is an empty promise for many children. Hospital recognition of child abuse is defined as much by class and race as by severity. A new propensity to criminalize family problems and the possible advent of government intrusions into the newborn nursery suggest a risk of more harm in the guise of help, which will affect the most vulnerable children and families. A retreat from reporting as the method of getting services to families is suggested as one means to ameliorate this crisis.
Computation of the effective solid angle in angular correlation experiments using gas targets

Abstract A simple method is presented to calculate the effective solid angle for a correlation experiment using a gas target. This method permits us also to calculate the angular spread for each angle setting. A computer program using this method is presented in the appendix.
The Prevention Principle: A Pragmatic Framework to Prevent Destructive Conflict

When should the United Nations, the United States or the European Union intervene in foreign conflicts? Should they intervene at all or would another entity be in a better position to do so? These are some of the underlying questions of this article, in which the authors discuss concrete ways to prevent destructive conflicts, typically international armed conflicts. They put forward a pragmatic framework, called the Prevention Principle, to recognize and prevent destructive conflict at the earliest possible time at the lowest legitimate level. The authors set out the nature of destructive conflicts, explain how early intervention should occur, and propose a model to identify the most appropriate and effective intervener.
Management and long-term outcome of neonatal Ebstein anomaly

Objective The objective of this study was to review the long-term results of symptomatic patients with Ebstein anomaly in the neonatal period. Methods The medical records of 40 neonates with a diagnosis of Ebstein anomaly who were admitted to our institution between January 1988 and June 2008 were retrospectively reviewed. Primary outcomes studied included patient survival and need for reintervention. Results No early intervention was required in 16 of the 40 patients with a hospital survival of 94% (15/16) and no late mortality. The remaining 24 patients underwent surgical intervention in the neonatal period. A shunt alone was performed in 9 patients with an actuarial survival of 88.9% at 1 year and 76.2% at 5 and 10 years. For the patients undergoing intervention on the tricuspid valve, survival estimates for the 11 patients with a right ventricular exclusion procedure were 63.6% at 1, 5, and 10 years and 47.7% at 15 years compared with 25.0% at 1, 5, and 10 years for the 4 patients with tricuspid valve repair. All long-term survivors were in New York Heart Association class I or II, and only 1 patient required antiarrhythmic medication. Conclusion Symptomatic neonates with Ebstein anomaly requiring no intervention or shunting alone have good long-term survival. For patients needing intervention on the tricuspid valve, overall survival is lower. For these patients, right ventricular exclusion may be superior to tricuspid valve repair.