cssi/SciSciGPT-SciSciNet huggingface dataset:
Plasma and Kidney Angiotensin Peptides: Importance of the Aminopeptidase A/Angiotensin III Axis.

Background The renin-angiotensin system is a complex regulatory hormonal network with a main biological peptide and therapeutic target, angiotensin (Ang) II (1-8). There are other potentially important Ang peptides that have not been well evaluated. Methods Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used for concurrent evaluation of multiple Angs downstream of Ang I (1-10) and Ang II (1-8) in kidney and plasma from wild-type (WT) mice. Angiotensin converting enzyme 2 knockout (ACE2KO) was also used as a way to examine the Angs profile in the absence of ACE2, an enzyme that cleaves both Ang I (1-10) and Ang II (1-8). Results In plasma from both WT and ACE2KO, levels of Ang I (1-10), Ang III (2-8), and Ang (2-10) were the highest of all the renin-angiotensin system (RAS) peptides. The latter two peptides are products of aminopeptidase A cleavage of Ang II (1-8) and Ang I (1-10), respectively. In contrast, plasma levels of Ang II (1-8), and Ang (1-7), the product of Ang II (1-8) cleavage by ACE2, were low. In kidney from both WT and ACE2KO, Ang II (1-8) levels were high as compared to plasma levels. In the ACE2KO mice, a significant increase in either Ang II (1-8) or a decrease in Ang (1-7) was not observed in plasma or in the kidney. Conclusion RAS-focused peptidomic approach revealed major differences in Ang peptides between mouse plasma and kidney. These Ang peptide profiles show the dominance of the aminopeptidase A/Ang (2-10) and aminopeptidase A/Ang III (2-8) pathways in the metabolism of Ang I (1-10) and Ang II (1-8) over the ACE2/Ang (1-7) axis. Ang III (2-8) and other peptides formed from aminopeptidase A cleavage may be important therapeutic RAS targets.
Comedia del valor de las letras y las armas : nueva luz sobre la historia del capitán cautivo y sus hermanos (DQ 1, 37-45)

The tale of the captive captain, Ruy Perez de Viedma, and his brothers, as well as Don Quixote’s discourse on arms and letters which serves as its prologue, have been well studied, but a model combining both parts of this thematic unit found in the first part of Don Quixote has not been previously identified. The anonymous late-sixteenth-century play Comedia del valor de las letras y las armas , here studied as a source for the first time, may well have been known to Cervantes and provides extensive parallels of theme and characterization to Cervantes’ treatment of both Renaissance discourse on preserving peace and the folktale of three brothers and their respective professions. It brings into sharp focus that these chapters resolve the debate between arms and letters in favor of a third element, social power and money.
Multi-Tiered Systems of Support to Improve Outcomes for Youth in Juvenile Justice Settings: Guiding Principles for Future Research and Practice

In 2014, the joint Departments of Education and Justice released Guiding Principles for Providing High-Quality Education in Juvenile Justice Secure Care Settings, including I) creating a climate and conditions conducive to learning, II) providing necessary resources to support education opportunities, III) recruiting, training, and retaining qualified staff, IV) implementing rigorous and relevant curricula, and V) supporting successful community reentry. This article outlines these five guiding principles, including ways that each can be addressed by adopting positive behavioral interventions and supports frameworks, a type of multi-tiered system of support, facility-wide within secure care juvenile justice facilities. Illustrations of how to address each guiding principle are supported by articles from the special issue of Residential Treatment for Children and Youth on multi-tiered systems of support within secure residential juvenile facilities.
Parenting while powerless: Consequences of “the talk”

ABSTRACTHistorically, African American parents have struggled to negotiate the tensions related to raising their children in a hostile society. The recent and tragic events involving the murders of unarmed African American boys and men by police officers, enraged motorists, and vigilante neighbors have sparked a resurgence in discussion and activism related to these historic tensions. In addition to protests and a heightened level of public discourse, there is also new emphasis on African American parents having “the Talk” with their children, particularly their sons. “The Talk” represents the “surviving interactions with police or other members of authority” discussion and is largely considered an essential rite of passage in African American homes. And, although the pretext for “the Talk” is providing children with the rule book for survival from an authoritative source, the subtext for this conversation is the inherent powerlessness of African American parents and their inability to protect their child...
Effects of training in therapy on trainees' attitudes.

Two preliminary investigations of what happens to trainee attitudes as a result of therapy supervision for a short period of time are reported; in both studies attitude change was negligible. A third study, currently in progress, measures changes over a longer duration.
Spatial cognition following early-life seizures in rats: Performance deficits are dependent on task demands.

Abstract Cognitive impairment is a common comorbidity in childhood epilepsy. Studies in rodents have demonstrated that frequent seizures during the first weeks of life result in impaired spatial cognition when the rats are tested as juvenile or adults. To determine if spatial cognitive deficits following early-life seizures are task-specific or similar across spatial tasks, we compared the effects of early-life seizures in two spatial assays: 1) the Morris water maze, a hippocampal-dependent task of spatial cognition and 2) the active avoidance task, a task that associates an aversive shock stimulus with a static spatial location that requires intact hippocampal–amygdala networks. Rats with early-life seizures tested as adults did not differ from control rats in the water maze. However, while animals with early-life seizures showed some evidence of learning the active avoidance task, they received significantly more shocks in later training trials, particularly during the second training day, than controls. One possibility for the performance differences between the tasks is that the active avoidance task requires multiple brain regions and that interregional communication could be affected by alterations in white matter integrity. However, there were no measurable group differences with regard to levels of myelination. The study suggests that elucidation of mild cognitive deficits seen following early-life seizures may be dependent on task features of active avoidance.
Study of effective information-based management of measuring instruments in hospitals

This paper is to advocate setting up hospital information management system, which is information-based, normalized and scientific, of measuring instruments by use of hospital information network management platform, measuring instruments. All metering system management modules shall be established systematically, making a variety of measuring instruments calibration test statistical reports to enable operating procedures normalized. A simple and functional measurement management system with flexible statistical functions is an effective modern tool for hospital, which can always fully grasp and understand the dynamics of hospital-wide information on measuring instruments, as well as perform effectively control, supervision and dynamic tracking of management measuring instruments. The establishment of hospital management information system of measurement makes the hospital leadership, measurement-managing department, measuring-instruments user department contact each other through the online network platform, which brings fast and accurate transmission of information management, greatly improving the measurement of management efficiency and reduce management costs of measurement. Information-based management not only saves manpower and material resources, improves efficiency of work and transmission of information, shortens decision-making cycle and fastens processing speed, but also ensures the accuracy and standardization of data. Being under management based on information, measuring instruments in the hospital ensure the accuracy and validity of measurement, which positively reduces medical errors, improves the quality of medical services so as to protect the health and safety of children.
Nudging the digital pirate: behavioral issues in the piracy context

Piracy is a significant source of concern facing software developers, music labels, and movie production companies. Firms continue to invest in digital rights management technologies to thwart piracy, but their efforts are quickly defeated by hackers and pirates. The goal of this research is to provide actionable insights that management may use to mitigate piracy. We conduct two studies to explore behavioral issues in the piracy context. In the first study, we theorize and provide support that moral obligation may mediate other constructs from the theory of planned behavior. We believe this is a consequence of the desire for an individual to rationalize unethical behavior, especially when the crime is victimless. In the second study, we relate piracy to an abstract public goods problem in economics. Specifically, we design and implement an experiment with several treatments to investigate the role of information targeting on coordination in a multi-threshold public goods game. Our analysis of the experimental data shows that by targeting information about the contribution rate to a public good, one may be able to achieve improvements in coordination and thereby enable an increased allocation to the good. In contrast, providing information randomly does not improve cooperation and coordination any more than with no information at all. Note that our random information treatment approximates strategies currently used in practice for educating consumers about digital piracy. Overall, our findings in these two studies provide valuable insights into understanding piracy behavior, and developing appropriate information strategies to mitigate digital piracy.
Percutaneous Sentinel Node Biopsy in Breast Cancer: Results of a Phase 1 Study

While sentinel lymph node dissection (SLND) provides axillary staging, recent trials question the necessity of removing positive nonsentinel axillary lymph nodes (LN) in breast cancer. We sought to determine the technical feasibility of percutaneous core needle biopsy (PNB) of axillary sentinel lymph nodes (SLNs). After dual tracer injection, 25 patients underwent intraoperative axillary ultrasound and ultrasound guided per PNB of the axillary LN at the site of radiotracer uptake, followed by standard SLND. The primary outcome measure was successful correlation of PNB with SLN, defined as: (1) similar final pathology in core and SLN and (2) presence of blue staining and/or radiotracer in the core or gross evidence of PNB at the SLN (e.g., transected SLN). Preincision axillary ultrasound identified a LN (mean size 1.15 ± 0.67 cm) at the site of radioactive tracer in 92 % (23 of 25) of cases. Gross evidence of PNB at the SLN was found in 76 % (19 of 25) of cases. Blue staining, radioisotope, and pathology matched in core and SLN specimens in 36 % (9 of 25), 64 % (16 of 25), and 72 % (18 of 25) of cases, respectively. Overall, successful correlation of core biopsy with SLN occurred in 72 % (18 of 25) of cases. Results of this phase I study demonstrate that PNB of the SLN is technically feasible, but further refinement of technique is warranted to improve correlation of core biopsy to SLND.
Catalysis, enzymes, and proteins

Catalysis The topic of catalysis recurs throughout fuel chemistry. A catalyst increases the rate of a chemical reaction without itself being permanently altered by the reaction, or appearing among the products. The key word is rate . Catalysts affect reaction kinetics. A catalyst affects reaction rate by providing a different mechanism for the reaction, usually one that has a markedly lower activation energy than that of the non-catalyzed reaction. Catalysts do not change reaction thermodynamics; they do not alter the position of equilibrium [A], but they can help reach equilibrium much more quickly. And, they cannot cause a thermodynamically unfavorable reaction to occur. Catalysts can be classified as homogeneous, in the same phase as the reactants and products, and heterogeneous, in a separate phase. Homogeneous catalysts mix intimately with the reactants. This good mixing often leads to enormous rate enhancements, in some cases by more than eight orders of magnitude. But, because they are in the same phase as the reactants and products, industrial use would require a separation operation for catalyst recovery downstream of the reaction, unless one were willing to throw away the catalyst (possibly allowing it to contaminate the products) as it passes through the reactor. For many catalytic processes, the catalyst costs much more than the reactants do, so loss of the catalyst would result in a significant economic penalty. Usually, heterogeneous catalysts have no major separation problems, thanks to their being in a separate phase from reactants and products. However, because of their being in a separate phase, mass-transfer limitations can hold up access of the reactants to the catalyst, or hold up departure of products. Heterogeneous catalysis can also be affected by various problems at the catalyst surface (discussed in Chapter 13). Large-scale industrial processing almost always favors use of heterogeneous catalysts, to avoid possibly difficult downstream separation issues. Nevertheless, steady progress is being made in finding ways to overcome separation problems with homogeneous catalysts, including, as examples, membrane separation, selective crystallization, and use of supercritical solvents.
Carboniferous sediment dispersal in the Appalachian-Ouachita juncture: Provenance of selected late Mississippian sandstones in the Black Warrior Basin, Mississippi, United States

Abstract The Black Warrior Basin is one of several Carboniferous foreland basins along the Appalachian–Ouachita fold-thrust belt in the southeastern United States. Sediment dispersal within the Black Warrior Basin has been a long-debated topic because of a complex tectonic history and the potential interaction between the Appalachian and Ouachita orogenic belts, as well as far field sediment sources. Three dispersal patterns have been proposed, including dispersal routes from the craton, dispersal via the Appalachian foreland, and dispersal from the arc side of the Ouachita suture, but sediment dispersal in the Black Warrior Basin remains inconclusive. In this study, sandstone modal analysis and U–Pb detrital zircon geochronology are used to document the provenance and potential dispersal patterns for selected Mississippian sandstone units in the Black Warrior Basin, Missouri, USA. Results show that the majority of the Lewis, Evans, Sanders, and Carter sandstones are sublitharenite to mature quartzarenite and fall within the Cratonic Interior field on Q–F–L diagrams. U–Pb detrital zircon analyses of the Lewis, Sanders, and Carter sandstones show that there are four distinctive age clusters, including a prominent Paleozoic age cluster (~ 350–500 Ma), a broad Grenville age cluster (~ 900–1350 Ma), and two minor age clusters of the Granite–Rhyolite (~ 1360–1600 Ma) and the Yavapai–Mazatzal (~ 1600–1800 Ma) provinces. All Mississippian sandstones have similar age distributions except for the Lewis sandstone, which lacks zircon grains from the Superior province (>~2500 Ma). Based on the compositional maturity, similarity of age distributions, and changes of relative abundance among different age groups, we conclude that the Late Mississippian sandstone units analyzed during this study were derived from the Laurussian craton and the northern part of the Appalachian foreland through a major axial drainage that occupied the Mississippi Valley Graben.
Multiphase Flow in Unconventional Petroleum Reservoirs

This chapter discusses physical processes and their mathematical description of oil and gas flow and production in unconventional reservoirs. To describe oil/gas flow behavior in low-permeability, heterogeneous porous or fractured, and stress-sensitive unconventional reservoirs, a mathematical model is presented to incorporate key physical processes, i.e., non-Darcy flow, Klinkenberg effect, and geomechanical coupling, as well as adsorption. It shows that the mathematical model is suitable for modeling various types of tight and shale oil and gas reservoirs using discrete-, hybrid-, double-, and other multiple-continuum conceptual models for multiscaled fracture systems. The mathematical models and numerical approaches can be used and further improved upon for quantitative studies of unconventional reservoir dynamics, fractures and their effects on oil or gas production, well and stimulation design, and optimal production schedules in the field, as demonstrated using a simulation example.
Identifying amino acids sensitive to mutations using high-throughput rigidity analysis

Understanding how an amino acid substitution affects a protein's stability can aid in the design of pharmaceutical drugs that aim to counter the deleterious effects caused by protein mutants. Unfortunately, performing mutation experiments on the physical protein is both time and cost prohibitive. Thus an exhaustive analysis which includes systematically mutating all amino acids in the physical protein is infeasible. Computational methods have been developed over the years to predict the effects of mutations, but even many of them are computationally intensive else are dependent on homology or experimental data that may not be available for the protein being studied. In this work we motivate and present a computation pipeline whose only input is a Protein Data Bank file containing the 3D coordinates of the atoms of a biomolecule. Our high-throughput approach uses our rMutant algorithm to exhaustively generate in silico mutants with amino acid substitutions to Glycine, Alanine, and Serine for all residues in a protein. We exploit the speed of a fast rigidity analysis approach to analyze our protein variants, and develop a Mutation Sensitivity (MuSe) Map to identify residues that are most sensitive to mutations. We present three case studies and show the degree to which a MuSe Map is able to identify those amino acids which are susceptible to the effects of mutations.
We Can’t Bring Back the Passenger Pigeon: The Ethics of Deception Around De-extinction

There is much hype around the idea of bringing the Passenger Pigeon back from extinction. However, ‘de-extinction’ is a fantasy that is not grounded in science. The proposed plans for ‘de-extinctio...
Catecholamine Metabolism via Monoamine Oxidase Disrupts Oxidative Phosphorylation Efficiency in Glutathione Peroxidase-4 Deficient Mouse and Human Myocardium

Glutathione peroxidase-4 (GPx4) is a selenoenzyme expressed in mitochondria and nuclear compartments which exclusively neutralizes lipid peroxides. Monoamine oxidase (MAO), an outer mitochondrial membrane-bound enzyme responsible for catecholamine metabolism, produces a reactive catechol-aldehyde and H2O2 upon substrate deamination. Current findings in human myocardial samples from our lab show that obese/diabetic patients exhibit greater maximal MAO activity and content, but lower GPx4 compared with nondiabetic patients, suggesting that both increased MAO and decreased GPx4 act to compound levels of reactive aldehyde species in diabetic myocardium. Our preliminary experiments using nitro blue tetrazolium staining have revealed protein modification by catechol-aldehydes derived from norepinephrine (NE) and dopamine (DA) in whole heart lysate and isolated cardiac mitochondria from mice and humans, an effect mitigated by MAO inhibitors. We further examined the effects of catecholamine metabolism via MAO on ATP production and O2 consumption (OxPhos) in isolated cardiac mitochondria prepared from WT and GPx4-deficient (GPx4+/-) mice, and in permeabilized myofibers prepared from human atrial myocardium. Both DA and NE significantly decreased ATP production and O2 consumption in GPx4+/- mice, but not WT, by 15% and 13%, respectively (p
Child-Focused Versus School-Focused Sociometrics: A Challenge for the Applied Researcher

We explored the feasibility and usefulness of collecting peer sociometric data on a sample of children from across southeastern New England who were being followed in a community-based longitudinal study. Applying what has typically been a school-focused research methodology to this child-focused follow-up highlighted challenges faced by applied researchers wanting to make use of this powerful method for assessing social adjustment in their school-aged participants. It also allowed us to conduct a “real-world” test of the 1998 sociometric sampling study by Terry et al., who concluded that valid sociometric data can be obtained from a small pool of classroom peers. Through presentation of our efforts to obtain sociometric data on 57 target children and the results of these child-focused sociometrics, we illustrate and discuss the methodological and pragmatic issues surrounding the use of child-focused (in contrast to the more typical school-focused) approach to sociometrics. School consent for child-focused sociometrics was the most formidable challenge to successful data collection in this study. In our discussion we present new data from a child-focused sociometric assessment of psychiatrically hospitalized children that demonstrate how emphasizing the clinical relevance of these data can help clinicians and applied researchers better address this particular challenge.
Joint implants: An elution solution

An optimized drug-eluting polymer for the surface of articulating artificial joints may make them infection-free.
Glycan profiling of proteins using lectin binding by Surface Plasmon Resonance

Glycan profiling of proteins was studied through their lectin binding activity by Surface Plasmon Resonance (SPR). To validate the method, we monitored specific lectin binding with sequential removal of sugar moieties from human transferrin using specific glycosidases. The results clearly indicated that glycans on the protein can be identified by their selective binding activity to various lectins. Using this method, we characterized Fc glycosylation profiles of therapeutic peptibodies and antibodies expressed in mammalian cells (CHO and HEK 293 6E cells), with E. coli expressed proteins as the negative controls. We observed that antibodies expressed in CHO cells did not contain any sialic acid, while antibodies expressed in 293 6E cells contained sialic acid. CHO cell expressed antibodies were also more heavily fucosylated than the ones expressed by 293 6E cells. We further applied this method to measure the fucose composition of glycan engineered mouse antibodies, as well as to determine mannose composition of human antibody variants with depletion or enrichment of high mannose. The glycan profiles generated using this method were comparable to results from 2-AB labeled glycan analysis of normal-phase separated glycans, and Fc gamma receptor binding activity of the glycan engineered antibodies were consistent with their glycan profiles. Hence, we demonstrated that SPR lectin binding analysis can be a quick alternative method to profile protein glycosylation.
Motion robust high resolution 3D free-breathing pulmonary MRI using dynamic 3D image self-navigator.

Purpose To achieve motion robust high resolution 3D free-breathing pulmonary MRI utilizing a novel dynamic 3D image navigator derived directly from imaging data. Methods Five-minute free-breathing scans were acquired with a 3D ultrashort echo time (UTE) sequence with 1.25 mm isotropic resolution. From this data, dynamic 3D self-navigating images were reconstructed under locally low rank (LLR) constraints and used for motion compensation with one of two methods: a soft-gating technique to penalize the respiratory motion induced data inconsistency, and a respiratory motion-resolved technique to provide images of all respiratory motion states. Results Respiratory motion estimation derived from the proposed dynamic 3D self-navigator of 7.5 mm isotropic reconstruction resolution and a temporal resolution of 300 ms was successful for estimating complex respiratory motion patterns. This estimation improved image quality compared to respiratory belt and DC-based navigators. Respiratory motion compensation with soft-gating and respiratory motion-resolved techniques provided good image quality from highly undersampled data in volunteers and clinical patients. Conclusion An optimized 3D UTE sequence combined with the proposed reconstruction methods can provide high-resolution motion robust pulmonary MRI. Feasibility was shown in patients who had irregular breathing patterns in which our approach could depict clinically relevant pulmonary pathologies. Magn Reson Med 79:2954-2967, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Facial Width-to-Height Ratio Does Not Predict Self-Reported Behavioral Tendencies

A growing number of studies have linked facial width-to-height ratio (fWHR) with various antisocial or violent behavioral tendencies. However, those studies have predominantly been laboratory based and low powered. This work reexamined the links between fWHR and behavioral tendencies in a large sample of 137,163 participants. Behavioral tendencies were measured using 55 well-established psychometric scales, including self-report scales measuring intelligence, domains and facets of the five-factor model of personality, impulsiveness, sense of fairness, sensational interests, self-monitoring, impression management, and satisfaction with life. The findings revealed that fWHR is not substantially linked with any of these self-reported measures of behavioral tendencies, calling into question whether the links between fWHR and behavior generalize beyond the small samples and specific experimental settings that have been used in past fWHR research.
Experimental Study of the NaK 31Π State

Abstract We report the results of an optical–optical double resonance experiment to determine the NaK 3 1 Π state potential energy curve. In the first step, a narrow band cw dye laser (PUMP) is tuned to line center of a particular 2( A ) 1 Σ + ( v ′, J ′) ← 1( X ) 1 Σ + ( v ", J ") transition, and its frequency is then fixed. A second narrowband tunable cw Ti:Sapphirelaser (PROBE) is then scanned, while 3 1 Π → 1( X ) 1 Σ + violet fluorescence is monitored. The Doppler-free signals accurately map the 3 1 Π( v , J ) ro-vibrational energy levels. These energy levels are then fit to a Dunham expansion to provide a set of molecular constants. The Dunham constants, in turn, are used to construct an RKR potential curve. Resolved 3 1 Π( v , J ) → 1( X ) 1 Σ + ( v ", J ") fluorescence scans are also recorded with both PUMP and PROBE laser frequencies fixed. Comparison between observed and calculated Franck–Condon factors is used to determine the absolute vibrational numbering of the 3 1 Π state levels and to determine the variation of the 3 1 Π → 1( X ) 1 Σ + transitiondipole moment with internuclear separation. The recent theoretical calculation of the NaK 3 1 Π state potential reported by Magnier and Millie (1996, Phys. Rev. A 54, 204) is in excellent agreement with the present experimental RKR curve.
Dose Rate Effects in a Precipitation Hardened Nickel-Aluminum Alloy

A Ni-14 at. % Al alloy containing γ′ (Ni3Al) precipitates was irradiated at 725°C with 2.8-MeV 58Ni+ ions to determine precipitate stability under irradiation. The doses examined were 0.81, 2.5, and 8.1 displacements per atom (dpa) at both of two dose rates: 4.4 x 10-2 dpa/sec and 4.4 x 10-4 dpa/sec. Specimens were examined by transmission electron microscopy. The precipitates in the lower-dose-rate samples were seen to develop complex contrast features after irradiation but to retain their original size. The original precipitates in the higher-dose-rate samples developed a ragged appearance around the edges as if pieces were being dissolved, and a second smaller class of precipitates appeared in the matrix, and by 8.1 dpa the entire original precipitate size distribution had been converted to the new precipitates. These differences due to dose rate are not explained by current models of the behavior of precipitates under irradiation.
Bison body size and climate change.

The relationship between body size and temperature of mammals is poorly resolved, especially for large keystone species such as bison (Bison bison). Bison are well represented in the fossil record across North America, which provides an opportunity to relate body size to climate within a species. We measured the length of a leg bone (calcaneal tuber, DstL) in 849 specimens from 60 localities that were dated by stratigraphy and 14C decay. We estimated body mass (M) as M = (DstL/11.49)3. Average annual temperature was estimated from δ18O values in the ice cores from Greenland. Calcaneal tuber length of Bison declined over the last 40,000 years, that is, average body mass was 37% larger (910 ± 50 kg) than today (665 ± 21 kg). Average annual temperature has warmed by 6°C since the Last Glacial Maximum (~24-18 kya) and is predicted to further increase by 4°C by the end of the 21st century. If body size continues to linearly respond to global temperature, Bison body mass will likely decline by an additional 46%, to 357 ± 54 kg, with an increase of 4°C globally. The rate of mass loss is 41 ± 10 kg per°C increase in global temperature. Changes in body size of Bison may be a result of migration, disease, or human harvest but those effects are likely to be local and short-term and not likely to persist over the long time scale of the fossil record. The strong correspondence between body size of bison and air temperature is more likely the result of persistent effects on the ability to grow and the consequences of sustaining a large body mass in a warming environment. Continuing rises in global temperature will likely depress body sizes of bison, and perhaps other large grazers, without human intervention.
Why Instagram? The Role of Telepresence and Transportation in Visual Content Marketing

This experimental study focuses on the effects of a type of image on story construction and how consumers are transported to a branded photo narrative, which is expected to engender attitudinal change and relational outcomes. In addition, this study aimed to discover the mediating role of telepresence, the extent to which a consumer feels present in the mediated environment, on the relationship between a brand's photo-type and the level of consumers' transportation. This experimental study found that respondents who were exposed to the story-focused stimuli reported greater levels of transportation compared to respondents exposed to the product-focused stimuli and that telepresence mediates the relationship between photo-type (story vs. product-focused) and transportation. Lastly, findings indicate that transportation predicts consumers' positive change in attitude towards the brand and self-brand connection. Theoretical and managerial implications will be presented based on findings of this study.
One down, one to go: coronary anomaly dual LAD blood supply with worsening chronic stable angina and 100% occluded left short LAD type IV variant

Although rare, usually asymptomatic, and without concurrent disease, dual left anterior descending arteries (LAD) poses great challenges. We describe a 55-year-old male with no history of coronary disease, who presented with worsening substernal chest pain with exertion, and was ruled out for myocardial infarction. On left heart catheterization and subsequent computed tomography angiogram, he was determined to have a dual LAD with a long LAD emerging from the right coronary artery. Moreover, this long LAD gave collaterals to a native long diagonal that ran parallel to this vessel from the left system and was chronically occluded. The long LAD, consistent with type IV classification, traveled in the anterior intraventricular groove to supply left ventricular myocardium; the chronically occluded long left native diagonal supplying lateral walls and apex is a unique variant. It is important to be aware of these anomalies to establish correct diagnoses and determine treatment options.
A brief overview of N-acetylaspartate and N-acetylaspartylglutamate.

In closing, it is anticipated that this conference will not only provide a comprehensive review of the current state of knowledge of NAA and NAAG but will also define the many important and critical questions that need to be addressed in future research. It is hoped that the proceedings of the conference will attract a broader interest in these moieties, as they have been linked to serious disorders including schizophrenia, Alzheimer’s Disease and pain. Given their remarkably high concentrations in the brain, the current level of research on NAAG and NAA seems to underestimate their potential significance.
Defining Palliative Care Needs in Parkinson's Disease.

Objectives Palliative care addresses the suffering of patients and families affected by progressive illness through the management of medical symptoms, psychosocial issues, and spiritual concerns. Although there is an emerging interest in applying palliative care to Parkinson's disease (PD), potential palliative care needs have not been systematically investigated in PD patients. Our primary objective was to determine the prevalence of clinically significant symptomatic, psychosocial, and spiritual issues in PD and understand their impact on health-related quality of life (HRQOL). Secondary objectives included comparing the level of palliative care needs of PD patients to advanced cancer patients and assessing preferences for advance care planning. Methods Ninety PD patients and 47 patients with advanced cancer were surveyed regarding potential palliative care needs, including symptom burden, mood, anticipatory grief, and spiritual well-being. PD patients completed additional scales regarding HRQOL, motor symptoms, cognitive impairment, and preferences regarding advance care planning. Results Potential palliative care needs, including high symptom burden and grief, were common in PD patients and contributed to HRQOL even when controlling for depression and motor severity. In all domains investigated, PD patients had similar or higher levels of palliative care needs as patients with advanced cancer. PD patients expressed a desire to complete advance directives early in the disease course and with a physician. Conclusions Palliative care needs contribute to HRQOL in PD and are of similar severity as cancer patients. This study supports and helps focus efforts to integrate palliative care principles in PD care across the spectrum of the disease.
A Deadbeat Control Algorithm Based on Adaptive Prediction Theory for Active Power Filter

Deadbeat control as a discrete system control method is widely used in active filter control system. But without the prediction deadbeat control is actually a difference a beat or two beats control, for this, the paper proposes a prediction based on adaptive line enhancer for active filter deadbeat control, accurate predicts system state after two beats with the historical datas. Theoretical derivation proves the adaptive prediction method’ s robustness is optimal in the sense of H ∞, experiments demonstrate that the proposed method is correct and feasible.
Hydrophobic adsorption chromatography of colony-stimulating activities and erythroid-enhancing activity from the human monocyte-like cell line, GCT

The human cell line, GCT, secretes hemopoietins into serum-free culture medium. The conditioned medium contains activities that stimulate neutrophil-monocyte, macrophage, eosinophil, and erythroid colony growth in human marrow cultures. We have used hydrophobic adsorption chromatography to separate a neutrophil-monocyte colony-stimulating factor (CSF) from the other colony-stimulating activities. This hydrophobic CSF has no eosinophil-stimulating activity and is virtually devoid of erythroid-stimulating activity.
Elusive Stories: Collecting and Preserving the Foreign-Language Ethnic Press in the United States

This study surveys the development of collections of foreign-language ethnic newspapers in American libraries and archives since the 1960s. Relying on a review of historical and media studies schol...
Calcium-Phosphatidylinositol Interactions in Secretory Cells and the Role of Arachidonic Acid

Since secretagogues express their actions by increasing \(C{{a}^{{{{2}^{ + }}}}}\) availability and promoting membrane phospholipid turnover, the fundamental action of \(C{{a}^{{{{2}^{ + }}}}}\) in stimulus-secretion coupling may be uncovered by elucidating its interactions with membrane phospholipids. The turnover of arachidonoyl phosphatidylinositol (PI) triggered by the \(C{{a}^{{{{2}^{ + }}}}}\)-dependent activation of phospholipase A2 and followed by the reincorporation of fatty acid into lysophospholipids, appears to be one feature that secretory systems have in common. Stimulated arachidonic acid turnover in position 2 of PI has now been demonstrated in a number of secretory systems, including adrenal cortex, rabbit peritoneal neutrophils, and exocrine pancreas. The relevance of this reaction to secretory phenomena is indicated by its requirement for \(C{{a}^{{{{2}^{ + }}}}}\), its rapid onset, and dose-response curves that parallel those of the secretory response. One or another of the products of this deacylation-reacylation cycle, including arachidonic acid metabolites and/or lysophospholipids, may participate in the cellular processes that accompany the export of secretory product from the cell. Products of the activation of phospholipase C, including diacylglycerol and/or inositol phosphates, may also serve as second messengers. Insight into the nature of the interactions between phospholipases A2 and C with regard to their putative physiological roles should shed significant light on the vital control mechanisms that regulate the secretory process.
Machine Learning in Legal Practice: Notes from Recent History

Often framed as a relatively new and controversial phenomenon, the application of machine learning (ML) techniques to legal analysis and decision-making in the US justice system has a rich yet under examined history. My research examines how ML came to be adopted as a standard tool for automating fact discovery for high-stakes civil litigation. By analyzing the key controversies and consensuses that emerge during the experimentation and early adoption phase of this technology (2008-2015), a useful case study presents itself in which an expert professional field wrestled with the challenges of integrating ML into sensitive decision-making workflows.
Transient Operation of the Trickling Filters

Trickling filter consists of column filled with loosely packed solid covered with biological slime; fluid (sewage liquor) is passed through column, and fluid and slime exchange mass; mechanism of transport is suggested to be adsorption; it is further postulated that first-order biochemical reaction takes place in slime; by forming material balance, set of partial differential equations, describing transient operation of trickling filter, is formulated and solved.
Self-organized cytoskeletal alignment during Drosophila mesoderm invagination.

During tissue morphogenesis, mechanical forces are propagated across tissues, resulting in tissue shape changes. These forces in turn can influence cell behaviour, leading to a feedback process tha...
Against Crisis Epistemology

People who perpetrate colonialism often defend their actions as necessary responses to real or perceived crises. Epistemologies of crisis involve knowing the world in such a way that a certain present is experienced as new. I will discuss newness in terms of the presumptions of unprecedentedness and urgency. In contradistinction to an epistemology of crisis, I will suggest that one interpretation of certain Indigenous intellectual traditions emphasizes what I will just call here an epistemology of coordination. Different from crisis, coordination refers to ways of knowing the world that emphasize the importance of moral bonds—or kinship relationships—for generating the (responsible) capacity to respond to constant change. Epistemologies of coordination are conducive to responding to expected and drastic changes without validating harm or violence.
Small modular reactors (SMRs): The case of the United States of America

Abstract This chapter presents an overview of the research and development (R&D) underway in the United States on small modular reactors (SMRs) including all reactor technologies. The responsibility for conducting SMR R&D within the US government is that of the US Department of Energy’s Office of Nuclear Energy (DOE-NE). DOE-NE’s program for supporting the near-term deployment of the light water-cooled SMRs (LW-SMRs) has been the “SMR Licensing Technical Support” (LTS) program, which spanned the FY2012-FY2017 time frame and is now essentially complete. Recent accomplishments from the LTS program are highlighted, including summaries of key design features for both the NuScale and Holtec-160 LW-SMRs. DOE-NE’s programs, initiatives, and approach, which have included a targeted and cooperative “public-private” focus via its Gateway for Accelerated Innovation in Nuclear (GAIN) program and recent funding opportunity announcement, are summarized. Most of this R&D centers on advanced SMRs using coolants other than water. DOE-NE’s initial effort in establishing an R&D program to support the development and demonstration of a “microreactor” for commercial and/or defense applications is briefly discussed. Final comments are offered as to the direction and content of future A-SMR R&D in the United States.
Service Coordination to Address Maternal Mental Health, Partner Violence, and Substance Use: Findings from a National Survey of Home Visiting Programs

Maternal risks such as poor mental health, partner violence, and substance misuse can undermine child health and development. Maternal and early childhood home visiting programs address these risks primarily through referral and coordination with community-based services, yet effects on these outcomes have been small. This study assessed the strengths of local home visiting sites’ systems to support coordination of mental health, partner violence, and substance use services. Investigators recruited home visiting sites (N = 88) representing diverse models from a national practice-based research network, the Home Visiting Applied Research Collaborative (HARC). Web-based surveys assessed five implementation system supports for coordination and nine coordination activities drawn from the Measurement Framework for Coordination developed earlier in the project. Surveys also assessed seven coordination barriers identified in previous research. Sites varied in their implementation supports and coordination activities; on average, sites had stronger systems in place to support screening and referring families than to support linkage and follow-up. Implementation supports and activity scores were higher for mental health and partner violence than for substance use. Across all service needs, scores were highest for offering a referral and documenting the caregiver’s agreement for exchange of information between providers. Scores were lowest for offering a warm handoff. Lack of open slots and lack of transportation were major barriers to successful coordination for all three services. Results suggest that home visiting coordination could be strengthened by focusing on infrastructure for linkage and follow-up with services in the broader system of care.
The role of ifosfamide-doxorubicin chemotherapy in the treatment histology-specific, high grade, locally advanced soft tissue sarcoma: A 14-year experience.

e23529Background: To compare long-term outcomes of high grade, locally advanced, primary soft tissue sarcoma (STS), using Ifosfamide-Doxorubicin vs local therapy alone, in histology-specific sarcom...
Reporting Quality in Math Meta-Analyses for Students with or at Risk of Disabilities:

Researchers and practitioners alike often look to meta-analyses to identify effective practices to use with students with disabilities. The number of meta-analyses in special education has also exp...
The Role of Hepatic Glucose-6-phosphatase in the Regulation of Carbohydrate Metabolism

Publisher Summary Many attempts have been made to assign to enzymes the role of biochemical regulators as well as the function of catalysts. For example, changes in the rate of glycogenolysis have been associated with changes in phosphorylase activity. Although the mechanism of hormone action is not completely understood, many instances have been recorded of change in enzymatic activity under various endocrine conditions. Congenital diseases involving abnormal metabolism have been attributed to an ever-increasing number of enzyme deficiencies. Glucose-6-phosphatase, an enzyme involved in hepatic glucose production, has been studied from these several points of view. Recent studies have indicated that this enzyme may have a role in the regulation of hepatic glucose production. The activity of hepatic glucose-6-phosphatase is altered by fasting and alloxan diabetes, is virtually absent in glycogen storage disease and hepatoma, and is readily changed by endocrine manipulation. Such studies have been summarized in this chapter for review and evaluation. An extension of these observations has revealed a striking correlation between the activity of this enzyme and endocrine regulation of carbohydrate metabolism.
Factors Involved in Chitin Utilization by Vibrios

Because cholera remains an infectious disease of public health concern world wide, even with very few cases per year in the United States, the existance of pathogenic vibrios as normal inhabitants in estuarine waters require that we attempt to learn how these organisms maintain themselves in this environment (Colwell et al. 1980). Several investigators have reported that vibrios, although preferring high pH and some salinity, are intimately associated with chitin (Amako et al. 1987; Huq et al. 1984; Guthrie and Cofie, 1987). In those reports the point was made that the presence of organisms such as copepods, as well as larger chitin-bearing organisms, in the water increased the survival time of vibrios which were present.
Marital Rights, Mental Health, and Public Policy

The author discusses a comprehensive literature review on the mental health effects of marriage denial on lesbians and gay men and the role of mental health arguments in advocacy for marriage equality. The review, by Gil Herdt and Robert Kertzner, studied more than 150 reports on how marriage is related to mental health and the psychological effects of discrimination as codified by marriage denial on lesbians, gay men, and their families. Although we found a strong relationship between mental health and marriage, we encountered several critiques that challenged our focus on mental health in advocating for marriage equality. This paper summarizes findings of the original review and the strengths and limitations of a mental health perspective in advancing marriage equality.
Mechanism of interferon action

Abstract The ability of nonpreincubated as compared to micrococcal nuclease-treated mouse L cell-free extracts supplemented with 2′-deoxythymidine-3′, 5′-diphosphate (pTp) and ethyleneglycol-bis (β-aminoethyl ether)-N,N′-tetraacetic acid (EGTA) to catalyze the 2′,5′-oligoadenylate-dependent degradation of reovirus [3H]mRNA was investigated. 2′,5′-Oligo A tetramer enhanced degradation in nonpreincubated but not micrococcal nuclease-treated extracts. Neither pTp nor EGTA significantly affected the 2′,5′-oligo A-dependent degradation in nonpreincubated extracts. The presence of both micrococcal nuclease and calcium was required to establish the subsequent reduction in both 2′,5′-oligo A-dependent and -independent degradation observed in micrococcal nuclease-treated extracts containing pTp and EGTA.