cssi/SciSciGPT-SciSciNet huggingface dataset:
A web service-oriented approach to teaching CS/IS1

Web services technology is a burgeoning technology that has received much attention in the software industry in recent years under the broader umbrella of service-oriented architecture (SOA). The popularity of the service-oriented paradigm is echoed by Microsoft's Bill Gates, where in a memo to Microsoft's top managers and engineers, he states "The broad and rich foundation of the internet will unleash a 'services wave' of applications and experiences available instantly over the internet to millions of users" [1]. While Web services have been incorporated in many industries in the market place, they are only beginning to appear in the academia, primarily in upper division and graduate CS/IS curricula [2,3]. In this special session, we share our belief that Web services technologies can and should be introduced early in CS/IS curricula. We describe and demo a number of scenarios that illustrate how Web services can be integrated into CS1/IS1 to make these courses more interesting and more importantly, make the students better prepared for upper division classes and for the industry upon graduation. This special session also shares the results of our preliminary findings involving the aforementioned integration and introduces participants to the related courseware. Participants will also receive hands-on experience with some of the scenarios experimented in our study. The intended audience is CS/IS educators who are interested in a novel way of teaching CS1/IS1. NOTE: Participants are encouraged to bring a laptop with wireless access to the Web and with NetBeans.
Analysis of CerbB2 protein content of human glioma cells and tumor tissue

This study was designed to determine whether or not overexpression of the cerbB2 protein plays a role in the etiology of human gliomas. The cerbB2 gene codes for a 185 kDa cell membrane glycoprotein (gpl85cerbB2), which is similar to the receptor for epidermal growth factor. In initial studies, four human glioma cell lines (A-172, U118MG, U138MG and SW608) were used to develop techniques for detecting and quantifying gpl85cerbB2, using immunofluorescence microscopy, immunoblot analysis and flow cytometry. A-172 cells were found to have the highest content of gpl85cerbB2. More detailed studies utilizing A-172 cells indicated that cellular gpl85cerbB2 content changed little in response to conditions affecting cellular proliferative status, including serum deprivation, growth in low glucose medium and treatment with dimethyl sulfoxide. Ten human glioma specimens were then analyzed for cellular gpl85cerbB2 fluorescence and DNA content, using A-172 cells as a biological standard. Results indicated that gpl85cerbB2 was expressed at levels comparable to that of A-172 cells in many specimens, and at a very high level in one specimen. These data reiterate the problem of themolecular heterogeneity of human gliomas and indicate that gpl85cerbB2 may have a role in at least asubset of malignant glial tumors.
Properties of Composite Cylinders Fabricated by Bladder Assisted Composite Manufacturing (BACM)

An innovative manufacturing method, BACM (Bladder Assisted Composite Manufacturing), to fabricate geometrically complex, hollow parts made of polymeric composite materials is presented. BACM uses an internally heated bladder to provide the consolidation pressure at the required cure temperature, and thus produces high quality components. The feasibility of this manufacturing method is demonstrated by fabricating laminated composite cylinders using multiple cure pressures and wall thicknesses. The mechanical properties, energy consumed during the curing, and void content of the composite cylinders, are investigated in detail. The curing of composite cylinders was carried out by circulating heated air inside the bladder. Using the described heating method a number of 2-, 4-, and 6-ply composite cylinders made of E-glass/epoxy prepreg (Newport 321/7781) were prepared as test samples. Cylinders were cured at 121°C (250°F) for 2 hours using bladder pressures of 207 kPa (30 psi), 345 kPa (50 psi), 483 kPa (70 psi), and 621 kPa (90 psi). The mechanical behavior of the cylinders were characterized by compressing sample rings and loading ring segments in three-point bending. The fiber volume fraction and the void content of the cylinders were determined from resin burn-off experiments and density measurements. The cylinders produced using the BACM process were found to exhibit excellent surface quality. The elastic moduli, failure strength, and void contents of the cylinders were comparable to the values obtained from flat laminates produced by hot plate molding. Compared to conventional bladder manufacturing methods, the BACM process reduced the energy required to cure the cylinder by more than 50%.Copyright © 2011 by ASME
Who’s Afraid of a Final End? The Role of Practical Rationality in Contemporary Accounts of Virtue

In this paper I argue that excising a final end from accounts of virtue does them more harm than good. I attempt to establish that the justification of contemporary virtue ethics suffers if moved this one step too far from the resources in traditional accounts. This is because virtue, as we tend to describe it, rests on an account of practical rationality wherein the role of the final end is integral. I highlight the puzzles that are generated by the ellipsis that is “the role of a final end” in contemporary theories of virtue. The authors of these theories devise ad hoc solutions for these puzzles, puzzles that do not exist for traditional final end-based accounts. Recent critics of virtue ethics have certainly not been satisfied the explanations being offer in lieu of references to a final end. As a remedy, I recommend that the role of a final end be reintroduced in contemporary virtue ethics. I hope to explain that there is nothing to be frightened of and much to be gained.
The politics of book burning in al-Andalus

Six public book burnings took place in al-Andalus and the Maghrib from the middle of the tenth to the end of the twelfth century under five different regimes: Umayyad, Amirid, Abbadid, Almoravid, and Almohad. Examining each book burning in its political context provides insight into how rulers and jurists negotiated power in varied ways. Locating each burning in a developing series deepens understanding of its significance as a particular expression of negotiated power in comparative terms, and demonstrates how book burning became a symbol linking successive regimes.
Does testosterone supplementation improve health and function in elderly men

BACKGROUND Low serum testosterone levels are associated with age-related changes in physical and cognitive function. Replacement therapy could, therefore, help alleviate symptoms of aging.
Robert A. Mundell's Nobel Memorial Prize

Mundell's central claim to fame is to have recast entirely the way we think about the functioning of an economy with an open capital account, including the stark implications for policy. That is the purely intellectual part. But there is also the marketing department: the wonderful skill to capture the story in a few equations, a simple diagram. Just as John Hick's "Mr. Keynes and the Classics" (1937)1 brilliantly summarized the essence of Keynesian economics in the IS-LM diagram, Mundell's models likewise reduce to the textbook level a dramatically new view of the open economy. For that reason, his ideas have become and remained the central part of macroeconomics in the open economy, today as much as 30 years ago. With the Nobel Memorial Prize in Economics for Robert Mundell, the committee has recognized the stunning break in open economy macroeconomics brought about by his work. Of course, every scholar stands on the shoulders of generations of brilliant thinkers before him who have advanced knowledge in their turn. But it is no exaggeration to claim that after Mundell, it is difficult to go back to any of the previous writing in the field and find much inspiration, except from the perspective of the history of thought. And that is claiming very much, indeed, because it delegates to the upper bookshelves the work of James Meade (The Balance of Payments, 195 la and 1951b), the writings of Ohlin and Hawtrey, the great scholar Jacob Viner, Charles Rist, Gottfried Haberler, Charles Kindleberger and Robert Triffin, and all the other authors who represented the cream of the middle of the twentieth century. Most assuredly, none of them figures prominently in current international economics, quite unlike Mundell whose models continue to be the standard fare or, at least, a common benchmark. There is Keynes of the Treatise, but he himself soon left for different grounds. Great as the twentieth-century predecessors were, their lasting impact is mostly in the building stones they created for others. If there might have been a competitor at all, it would have been Lloyd Metzler (1973), that fonnidable scholar who was robbed of a great career by brain cancer. And
Age of stress-produced odorants and the Kamin effect.

The role of olfactory cues in the Kamin Effect was examined. In one experiment, rats were trained to avoid shock and then tested for the avoidance response after retention intervals of up to 24 hr. Source and age of the stress-produced odors present at testing varied for six groups of rats. Rats tested after 6 hr but in the presence of odors aged 24 hr performed the avoidance response better than rats tested after 6 hr in the presence of odors aged 6 hr, even though under both conditions the odors present were produced by a different rat. Conversely, rats tested after 24 hr in the presence of odors aged 6 hr did not perform as well as rats tested in the presence of odors appropriate to the retention interval. Rats tested in the presence of odors from other rats, but appropriate to the retention interval, displayed the traditional Kamin Effect. A second experiment showed that odors aged within the range previously employed had no effect upon initial acquisition of avoidance. The results are consistent with a memory retrieval interpretation of the Kamin Effect, with stress-produced odorants serving as time-dependent cues for retrieval of memory of previous avoidance training.
Two surgeons, one patient: The impact of surgeon–surgeon familiarity on patient outcomes following mastectomy with immediate reconstruction

Background: Mastectomy with immediate reconstruction requires the coordination and expertise of two distinct surgeons. This often results in several different combinations of mastectomy and reconstructive surgeons, but with an unknown impact on patient outcomes. We evaluate the effect of different surgical teams on complication rates following mastectomy and immediate reconstruction. Methods: Retrospective review of consecutive patients that underwent mastectomy with immediate prosthetic reconstruction from 4/1998 to 10/2008 at one institution was performed. Patients of the three highest-volume mastectomy and reconstructive surgeons were stratified by their individual combination of surgeons, resulting in nine different surgical teams. Complications were categorized by end-outcome. Appropriate statistics, including multiple linear regression, were performed. Results: Clinical characteristics were similar among patients (n ¼ 511 patients, 699 breasts) with the same mastectomy surgeon but different reconstructive surgeon. Mean follow-up was 38.4 � 25.7 months. For each mastectomy surgeon, the choice of reconstructive surgeon did not affect complication rates. Furthermore, the combined complication rates of the three highest-volume teams (n ¼ 384 breasts) were similar to the remaining lower-volume teams (n ¼ 315 breasts). Patient factors, but not the individual surgeon or surgical team, were independent risk factors for complications. Discussion: Our study suggests that among high-volume surgeons, complication rates following mastectomy with immediate reconstruction are not affected by the surgeonesurgeon familiarity. The individual surgeon’s expertise, and patient risk factors, may have a greater impact on outcomes than the team’s experience with each other. These results validate the efficacy and safety of the surgeon distribution model currently used by many breast surgery practices.
A substitute for skeletal age (Todd) for clinical use : the red graph method.

Summary The Todd inspectional method of estimating the uniformity of maturationin regions of the skeleton has been reviewed, and a new graph for expressing the equilibrium of bone growth is described and illustrated. The authors have found the Todd inspectional method and this new form of graph useful in the clinic as aids in studies of nutrition and growth in health and disease.
Hemoglobin Shelby [beta 131(H9) Gln----Lys] a correction to the structure of hemoglobin Deaconess and hemoglobin Leslie

Hemoglobin Shelby, detected in two unrelated black families, has an electrophoretic mobility like Hb F on cellulose acetate (pH 8.4) and a mobility between Hbs S and C on citrate agar (pH 6.2). Globin chain analysis in acid and alkaline buffers revealed an abnormal chain migrating between beta A and beta S. Tests for unstable hemoglobins were positive. Hematologic data on both families indicated carriers have mild anemia. The variant showed a slightly lower affinity for oxygen with normal cooperativity and Bohr effect, and its reactions with 2,3-diphosphoglycerate and inositol hexaphosphate were similar to those of Hb A. Sequence analysis indicated the substitution of lysine for glutamine at position 131 in the beta-chain. In a previous report (1) we described a variant, Hb Deaconess, in which this residue was deleted. On reexamination of the data, we find that Hb Deaconess is identical to Hb Shelby.
Diagnostic ability in relation to clinical seminars and extended-matching questions examinations.

Context At the Katholieke Universiteit Leuven, Belgium, final year medical students participate in 70 problem-solving clinical seminars over a period of 2 months, concentrating on clinical reasoning for formulating differential diagnoses. The clinical seminars end in an examination consisting of 200 extended-matching questions (EMQs). Objectives This study asks whether problem-solving clinical seminars improve clinical reasoning and whether the EMQ examination measures clinical decision making. In order to detect an increase in diagnostic ability, the Diagnostic Thinking Inventory (DTI) was applied. The research hypotheses were: (i) DTI scores will be higher after the seminars than before, and (ii) the correlations between DTI scores and EMQ examination scores will be significant. Methods In the academic year 2003–04, 3 series of problem-solving clinical seminars were held. At the beginning and end of each series the students filled in the DTI. This questionnaire measures 2 aspects of diagnostic thinking: the degree of flexibility in thinking, and how knowledge is structured in the memory. Results For all data together, the DTI scores after the clinical seminars were significantly higher than before. Pearson correlations between DTI scores and EMQ examination scores were low but significant, with the exception of post-test Structure (not significant). Conclusions Two months of intensive problem-solving clinical training was accompanied by an improvement in diagnostic thinking, as measured by DTI scores. Correlation between DTI scores and examination scores indicates that the EMQs measure an aspect of student achievement that is related to clinical reasoning.
Nonlocal pseudopotentials in molecular-dynamical density-functional theory: Application to SiO2.

Silicon dioxide is fundamental in geology, in the electronic materials industry, and in the glass industry. We have carried out an ab initio total energy minimization study of the structure and bonding of alpha cristobalite using nonlocal pseudopotentials in a Car-Parrinello--type molecular dynamical method. The electronic energy is expressed in the local-density approximation. The use of a separable nonlocal pseudopotential preserves the O(M lnM) scaling of the computation for M plane waves. The resulting theoretically computed minimum energy structure agrees well with experiment.
Primary sclerosing cholangitis : Diagnosis and management

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease caused by progressive inflammatory destruction of intrahepatic and extrahepatic bile ducts, and ultimately cirrhosis. PSC occurs primarily in patients with underlying ulcerative colitis and affects primarily young to middle-aged men. PSC is believed to be an autoimmune disease mediated by immune dysregulation in patients with genetic susceptibility. One possible mechanism for the development of PSC is the homing of memory lymphocytes to the biliary tract. Cholangiography is the gold standard for diagnosis of PSC. The typical radiologic findings include multifocal strictures and dilation involving the intrahepatic or extrahepatic biliary tract, or both. Although no medical therapy has proved beneficial, a variety of agents have been tested, some of which appear promising and deserve further study. High-dose ursodeoxycholic acid may have benefit in slowing disease progression; a multicenter placebo-controlled trial is ongoing. Liver transplantation is a good option for patients with advanced PSC, although the disease can recur after successful transplantation.
Eye movement testing in clinical examination

The clinical vision examination routinely includes an evaluation of ocular motor function. In a number of diverse situations, thorough objective recording of eye movements is warranted, using any of a variety of eye-tracking technologies that are available currently to clinicians. Here we review the clinical uses of eye tracking, with both an historical and contemporary view. We also consider several new imaging technologies that are becoming available in clinics and include inbuilt eye-tracking capability. These highly sensitive eye trackers should be useful for evaluating a variety of subtle, but important, oculomotor signs and disorders.
Electronic structure, dynamic susceptibility, and Néel temperature of the heavy-fermion magnet UCu5.

A formalism for treating both spin and orbital moment effects within the linearized muffin-tin orbital method is applied to the heavy-fermion magnet ${\mathrm{UCu}}_{5}$. A magnetic moment of 1.1${\ensuremath{\mu}}_{B}$ is found, in agreement with neutron-scattering data, which indicate a moment of 1.3${\ensuremath{\mu}}_{B}$. Moreover, the calculation finds that 70% of the density of states at ${E}_{F}$ is removed at the magnetic phase transition, in rough agreement with specific-heat data, which reveal a 60% reduction. Using a modification of the spin-fluctuation formalism of Moriya, we calculate a N\'eel temperature of 12 K, close to the experimental value of 15 K. Finally, a simple method for calculating the dynamic susceptibility including spin-orbit effects is introduced and used to discuss the nature of the two phase transitions observed in ${\mathrm{UCu}}_{5}$. We find that the renormalized dynamic susceptibility has a peak corresponding in energy to the neutron-scattering linewidth.
Infiltration and random roughness of a tilled and untilled claypan soil

Abstract No-tillage is generally assumed to increase infiltration and reduce runoff, but runoff from a claypan soil in Central Missouri, however, was greater from no-tillage plots than from moldboard plowed plots. The effect of simulated rainfall on infiltration and random roughness of tilled and untilled soil was measured. Four different tillage systems, each with and without surface cover were studied. An exponential decay function describes the change in random roughness for tilled soil exposed to rainfall kinetic energy. Although the differences were not statistically significant, among the uncovered tilled plots those with the highest random roughness had the highest infiltration. The bare no-tillage treatment had the lowest infiltration. Plots protected with shredded foam rubber infiltrated 88–248% more rainfall than similar bare plots.
Humeral morphology of the earliest apes

KNOWLEDGE of the skeletal anatomy of early hominoids has been based on various skeletal parts of fossil apes from the Miocene of East Africa and Europe. Postcranial remains from the earlier apes of the Oligocene of Egypt consisted of a single ulna, a basal phalanx and a hallucial metatarsal1–4. During 1977 a palaeontological expedition from the Cairo Geological Museum and Duke University recovered four new partial humeri attributable to these Egyptian apes. These specimens now provide the first evidence of humeral anatomy of Oligocene apes and permit a better assessment of primitive forelimb morphology and locomotor abilities of earliest hominoids.
Role of 5S ribosomal RNA in polypeptide synthesis

50S ribosomes obtained from Escherichia coli dissociated by dialysis into 5S rRNA and 44S particles, noting partially uncoiled structure
A Computer Program for Testing the Significance of Simple Structure

Bargmann's test for simple structure in factor analysis is briefly described, and a Fortran computer program which performs the test is presented.
An estimator for a class of non-linear distributed systems

The on-line estimation of unmeasured states in non-linear distributed systems faces considerable computational and implementation difficulties. In the present work an estimator is developed for a distributed system coupled through a highly non-linear term. The available secondary measurements and their time derivatives are used to preestimate the non-linear function. Then, the non-linearity is regarded as a known time dependent forcing term. The resulting estimation problem becomes linear, with a significant reduction of the computational scheme. The application of the method is illustrated with an example taken from the chemical industry; a tubular chemical reactor.
A Gendered Lifestyle-Routine Activity Approach to Explaining Stalking Victimization in Canada

Research into stalking victimization has proliferated over the last two decades, but several research questions related to victimization risk remain unanswered. Accordingly, the present study utilized a lifestyle-routine activity theoretical perspective to identify risk factors for victimization. Gender-based theoretical models also were estimated to assess the possible moderating effects of gender on the relationship between lifestyle-routine activity concepts and victimization risk. Based on an analysis of a representative sample of more than 15,000 residents of Canada from the Canadian General Social Survey (GSS), results suggested conditional support for lifestyle-routine activity theory and for the hypothesis that predictors of stalking victimization may be gender based.
Two‐point probability function for distributions of oriented hard ellipsoids

The macroscopic properties of two‐phase random heterogeneous media depend upon an infinite sequence of n‐point functions S(i)n(x1,x2,...,xn) giving the joint probability of finding n points with positions x1,x2,...,xn all in phase i. This paper reports the first study and calculation of the two‐point probability function S(i)2 for distributions of oriented, hard spheroids with eccentricity e in a matrix. This is a useful model of statistically anisotropic two‐phase media, enabling one to examine the special limiting cases of oriented disks (e=0), spheres (e=1), and oriented needles (e=∞).
Fragile and Resilient Trust and Their Roles in Economic Exchange

Interfirm collaboration and trust are topics currently exciting research interest. The literature treats trust as a unitary concept, providing little understanding of those processes that create tr...
The dexamethasone suppression test and completed suicide.

The present study was undertaken to further explore the relationship between the dexamethasone suppression test (DST) and suicide. Depressed inpatients who had undergone the DST at index admission and later committed suicide (n = 13) were matched for age, gender, diagnosis, and type of DST (1 mg, 2 mg) with depressed inpatients from the same hospital and study time period to form 2 groups: a suicide attempter group (n = 25) and a nonattempter group (n = 28). The suicide completers group had significantly higher 1600 postdexamethasone cortisol levels than the suicide attempters group and a significantly higher 1600 rate of DST nonsuppression compared with the suicide attempter + nonattempter combined group. Although the rate of DST nonsuppression did not differ between the suicide attempter and nonattempter groups, serious attempters had significantly higher 1600 cortisol levels and a statistically higher proportion of patients who completed suicide than nonserious attempters.(ABSTRACT TRUNCATED AT 250 WORDS) Language: en
Magnetic depopulation of hybrid magnetoelectric subbands in a quantum-well wire under an axial magnetic field.

Magnetic depopulation of hybrid magnetoelectric one-dimensional subbands is investigated within a model for a cylindrical quantum well with either a parabolic or infinitely steep confining potential. A criterion of the number of edge states is derived, which is found to be in good agreement with experiments. Our model also provides a quantitative description of the experimental observation of the damping effect of the state-density oscillations in the presence of a strong axial magnetic field. We make a specific prediction for the dependence of the critical magnetic field ${B}_{c}$ for the onset of the damping effect on the effective radius of the quantum wire, which is amenable to experimental verification.
5-Hydroxytryptamine in coelenterates.

IN an earlier report1, it was concluded from evidence obtained by pharmacological tests and paper chromatography that 5-hydroxytryptamine was a constituent of the sea-anemones, Metridium senile and Calliactis parasitica. More 5-hydroxytryptamine-like material was obtainable from Metridium tentacles, with their nematocysts, than from body wall which is relatively free of nematocysts. This led to the suggestion that 5-hydroxytryptamine might be a pain-producing factor in these stinging organelles. An independent study2 of material released on discharge of isolated Metridium nematocysts yielded two hydroxyindoles tentatively identified by chromatography as 5-hydroxytryptophan and bufotenine. The identification of 5-hydroxytryptamine in Calliactis has now been made quite certain3,4. However, the very large amount found in the coelenteric organ of this species and the relatively small amount in tentacles, coupled with the finding of little 5-hydroxytryptamine in Metridium and Anemonia sulcata, led Mathias, Koss and Schachter3,4 to conclude that it is unlikely that 5-hydroxytryptamine is associated with nematocysts. Further evidence is now available that this conclusion may not be fully warranted.
Pure plastic bending of sheet laminates under plane strain condition

Abstract Pure plastic bending of two- and three-ply laminates in plane strain condition has been investigated. Rigid-strain hardening material behavior has been assumed. For fibers which have been overtaken by the neutral axis and have experienced load reversal, a linear \ gs − \ ge relationship has been adopted. Different deformation zones have been recognized and relevant equations for the distributions of radial and tangential stresses in terms of material parameters and unknown variables have been determined. In each case, from continuity of radial stress at interlaminate boundaries, an expression for the current location of the neutral axis, in terms of the relative curvature, χ, and the relative thickness, η, has been obtained. A numerical scheme for the simultaneous solution of this expression, along with a thickness equation, has been developed. As a result, distributions of radial and tangential stresses, fiber movements, and bending moments have been calculated. The effect of material properties in terms of core/clad strength differential, and rate of strain hardening has been determined. Also, the influence of laminate geometry in two-ply, as well as symmetric and non-symmetric three-ply laminates, has been investigated.
MO‐EE‐A2‐06: The Puzzle of Repair Half‐Time in Mouse Lung Irradiation — Application of the GLQ Model

Purpose: The repair half‐time of radiation damage for mouse lung remains controversial. To solve the puzzle, we reanalyzed the existing data using the generalized LQ (gLQ) model that was developed to address the dilemma of LQ model in high dose region. Method and Materials: An animal dataset of mouse lung irradiation (Vegesna et al. IJMB 1985;47:413) was studied. In this experiment, mouse lung was irradiated with repeated dose from 1.15 Gy to 13.43 Gy. The endpoint was death due to radiation pneumonitis. A repair half‐time of 1.5 hour derived from the data of reciprocal of LD50 (lethal dose for 50% mortality) vs. dose‐per‐fraction was much longer than the repair half‐time of 0.4 hour published in the literature. In this study, the same data set was reanalyzed using both the LQ and the gLQ models. The c2 min method was adopted to fit the data and to evaluate the figure of merit for the two models. Results: Fixing the repair half‐time to 0.4 hour, the gLQ model fit the data much better than the LQ model: the reduced c2 min is 0.39 vs. 2.8 respectively. The a/b ratio was also quite different: 1.7 Gy for the gLQ model, and 3.3 Gy for the LQ model. While the gLQ model correctly predicted the high dose response based on low dose data, the LQ model could not reproduce the downward curvature shown in the LD50 plot. Conclusion: Our results indicate that the gLQ model provides a consistent interpretation of the mouse lung data across fraction sizes up to 13 Gy and naturally solves the puzzle of repair half‐time faced by the LQ model. Therefore, the gLQ model is useful to extend our clinical experience accumulated from conventional low‐dose fractionation to high dose irradiation schedules, including SRS/SBRT and HDR brachytherapy.
Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway

Purpose This study examines the anti-cancer effect of carnosol in human prostate cancer PC3 cells and its role in modulating multiple signaling pathways associated with carcinogenesis.
Bi-fascicular block on EKG as the initial presenting sign of cardiac sarcoidosis

A 41-year-old commercial painter with a history of tobacco use presented to the emergency department with complaints of cough, pleuritic chest pain and worsening dyspnea with exertion beginning 3 days prior to arrival. He had not responded to an outpatient regimen of bronchodilators and antibiotics. The patient denied any constitutional symptoms. On initial examination, the patient was afebrile with a room air oxygen saturation of 82%. Pulmonary examination revealed tachypnea with accessory muscle use and the presence of dry crackles in the posterior lung bases bilaterally and diffuse expiratory wheezing. Cardiovascular examination revealed mild jugular venous distention suggestive of right-sided heart failure. The rest of the patient’s physical exam was normal. A chest X-ray done did not show any evidence of air-space disease. Electrocardiogram (EKG) revealed sinus tachycardia with a rate of 110 and evidence of right bundle branch block and left anterior fascicular block (Fig. 1a). Thiswas not seen on a prior EKG from 1 year ago. Initial laboratory studies were unrevealing and serial sets of troponin I and CKMB showed no evidence of myocardial necrosis. The presence of bi-fascicular block on ECG in absence of any signs of myocardial ischemia prompted to consider the diagnosis of infiltrative myocardial disease. A cardiac MRI was obtained. Gadolinium-enhanced cardiac MRI (Fig. 1b) revealed abnormal signals seen in the right ventricular
Progesterone metabolism in Digitalis lanata

Abstract After the administration of progesterone-4- 14 C to a Digitalis lanata plant, the following radioactive metabolites were isolated: digitoxigenin, gitoxigenin, digoxigenin, 5α-pregnane-3,20-dione, 5β-pregnane-3,20-dione, 5α-pregnan-3β-ol-20-one, and Δ 5 -pregnen-3β-ol-20-one. The results suggest that progesterone may be na intermediate in the biosynthesis of cardenolides from pregnenolone.
(+/-)3,4-Methylenedioxymethamphetamine (MDMA) produces long-term reductions in brain 5-hydroxytryptamine in rats.

Abstract (±)3,4-Methylenedioxymethamphetamine (MDMA) was administered to rats as a single 40 mg/kg injection s.c. or 40 mg/kg s.c. every second day for 4 injections. Sixteen days following the last injection rats were killed. MDMA produced significant depletions of 5-HT and its metabolite 5-HIAA in the hippocampus and the frontal cortex. 5-HT was depleted to 30% of control value in the hippocampus following a single dose. 5-HT levels were not affected in the hypothalamus, suggesting differential effects on brain 5-HT systems. DA levels in the hypothalamus were significantly increased while NE levels in the frontal cortex were decreased to 73% of control following 4 doses of MDMA. MDMA, therefore, produces long-term depletions in 5-HT which suggests that it may act as a neurotoxin at 5-HT neurons in the brain of rats.
Studying the Relationship between System-Level and Component-Level Resilience

The capacity to maintain stability in a system relies on the components which make up the system. This study explores the relationship between component-level resilience and system-level resilience with the aim of identifying policies which foster system-level resilience in situations where existing incentives might undermine it. We use an abstract model of interacting specialized resource users and producers which can be parameterized to represent specific real systems. We want to understand how features, such as stockpiles, influence system versus component resilience. Systems are subject to perturbations of varying intensity and frequency. For our study, we create a simplified economy in which an inventory carrying cost is imposed to incentivize smaller inventories and examine how components with varying inventory levels compete in environments subject to periods of resource scarcity. The results show that policies requiring larger inventories foster higher component-level resilience but do not foster higher system-level resilience. Inventory carrying costs reduce production efficiency as inventory sizes increase. JIT inventory strategies improve production efficiency but do not afford any buffer against future uncertainty of resource availability.
UNDERSTANDING TEAMWORK: ANOTHER LOOK AT THE CONCEPTS

The interdisciplinary team is frequently utilized in the delivery of health care services. Considerable confusion surrounds the concept of teamwork. Three characteristics of teamwork are delineated to further the understanding of its structure and function. Integrative and coordinate teams are differentiated as models of practice. Implications for social work and nursing are highlighted.
The influence of personality, cognition, and behavior on perceptions and metaperceptions following alcoholic beverage selection in a dating situation

This study was designed to investigate perceptions and metaperceptions of individuals in a mixed sex dating situation in which they were offered alcohol. Male and female participants who were unfamiliar with one another were brought together in individual sessions and asked to imagine that they were on a blind date. At the outset of the 15-minute interaction, they each had an opportunity to select an alcoholic or nonalcoholic drink; after receiving their drink, they interacted privately. At the conclusion of the interaction, participants completed questionnaires that solicited their view of their partner and their perception of their partner's view of them. Results indicate that alcohol expectancies predicted alcoholic beverage selection. When women selected alcohol, they found their partner more likeable; those men whose partner was drinking believed that their partner found them more likeable. Additionally, when both partners were drinking they perceived each other as more extroverted, although they did not think their partner perceived them as extroverted. These results are discussed in terms of implications for further research on the role of alcohol as a cue in a mixed-sex social/dating environment.
Genome Nucleotide Composition Shapes Variation in Simple Sequence Repeats

Simple sequence repeats (SSRs) or microsatellites are a common component of genomes but vary greatly across species in their abundance. We tested the hypothesis that this variation is due in part to AT/GC content of genomes, with genomes biased toward either high AT or high CG generating more short random repeats that are long enough to enhance expansion through slippage during replication. To test this hypothesis, we identified repeats with perfect tandem iterations of 1‐6 bp from 25 protists with complete or near-complete genome sequences. As expected, the density and the frequency are highly related to genome AT content, with excellent fits to quadratic regressions with minima near a 50% AT content and rising toward both extremes. Within species, the same trends hold, except the limited variation in AT content within each species places each mainly on the descending (GC rich), middle, or ascending (AT rich) part of the curve. The base usages of repeat motifs are also significantly correlated with genome nucleotide compositions: Percentages of AT-rich motifs rise with the increase of genome AT content but vice versa for GC-rich subgroups. Amino acid homopolymer repeats also show the expected quadratic relationship, with higher abundance in species with AT content biased in either direction. Our results show that genome nucleotide composition explains up to half of the variance in the abundance and motif constitution of SSRs.
13 Transforming Archaeology, Transforming Materiality

The archaeological contribution to materiality has to date been less widely appreciated by practitioners outside the subdiscipline. This chapter argues that this is in part due to the identification of archaeological materiality with things, objects, or material culture, deriving from the twentieth-century history of Americanist archaeology in particular. While archaeologists have made important contributions to debates about the agency of objects, object biographies, and critiques of object/subject dichotomies, there are specific perspectives that archaeology could contribute that derive from the nature of archaeological sites as places consisting of material traces. This article examines in depth the concept of trace as it is used in broader social theory, and as it is instantiated in archaeological materialities. It is argued that for materialities of everyday life, in particular, traces have been the most effective kinds of materialities explored by archaeologists.
Blind sequence detection without channel estimation

This paper proposes a new blind sequence estimation method for single-input single-output (SISO) systems utilizing an optimal trellis search, which is performed by a channel-independent Viterbi algorithm (CIVA). In contrast to the traditional Viterbi algorithm that requires accurate channel estimation, CIVA does not require channel coefficients. Instead, the metrics are calculated from a bank of test vectors designed off-line. The proposed algorithm has outstanding performance under most of the channel conditions. Specifically, it does not suffer from ill-conditioned channels. In addition, it does not depend on channel correlation estimation and, therefore, has fast convergence. Simulations demonstrate its superior performance over even most training-based equalization algorithms.
An examination of market efficiency around hurricanes

Hurricane Andrew produced more than $21.5 billion in property damage in Florida and Louisiana. Hurricane Hugo caused about $7 billion in damage in North and South Carolina. Although both hurricanes were large, the magnitudes of their destruction and the geographic concentrations of their paths were markedly different. This study finds that Hugo and Andrew produced substantially different market reactions on property and casualty (P&C) firms. The industry was generally unaffected by Hugo, regardless of whether or not firms had exposure in the Carolinas. Andrew, on the other hand, generated a significant negative impact on firms with exposure in Florida or Louisiana. Other firms were not effected by Andrew. These observations indicate that the market demonstrated an ability to discriminate by the magnitude of hurricane and by P&C firms based on their degree of loss exposure.
Selection and the Marriage Premium for Infant Health

Previous research has found a positive relationship between marriage and infant health, but it is unclear whether this relationship is causal or a reflection of positive selection into marriage. We use multiple empirical approaches to address this issue. First, using a technique developed by Gelbach (2009) to determine the relative importance of observable characteristics, we show how selection into marriage has changed over time. Second, we construct a matched sample of children born to the same mother and apply panel data techniques to account for time-invariant unobserved characteristics. We find evidence of a sizable marriage premium. However, this premium fell by more than 40 % between 1989 and 2004, largely as a result of declining selection into marriage by race. Accounting for selection reduces ordinary least squares estimates of the marriage premiums for birth weight, prematurity, and infant mortality by at least one-half.
Early experiences with computed axial tomography colonography.

Abstract Background Computed axial tomography (CT) colonography is the latest radiologic technique to be used to image the large bowel. We studied its role as a diagnostic tool in colorectal practice. Methods One hundred and three patients suspected of having colorectal pathology underwent CT colonography. Results CT colonography suggested a diagnosis of colonic carcinoma in 18 patients, and 17 of these underwent surgery. A colorectal neoplasm was not found in only 1 patient who had extrinsic colonic compression by an ovarian cyst. Twenty-one patients had suspected colonic polyps on scanning. Subsequent endoscopy in 19 of these patients confirmed the presence of polyps in only 10. CT colonography also revealed valuable extracolonic pathology: 8 occult noncolonic neoplasms and 163 other incidental findings. Conclusions CT colonography has good patient compliance and is a useful diagnostic modality in detecting colorectal neoplasms. Its main advantage over other such investigative tools is its ability to detect extracolonic pathology.
Seasonal Shifts in the North American Monsoon

Analysis is performed on the spatiotemporal attributes of North American monsoon system (NAMS) rainfall in the southwestern United States. Trends in the timing and amount of monsoon rainfall for the period 1948–2004 are examined. The timing of the monsoon cycle is tracked by identifying the Julian day when the 10th, 25th, 50th, 75th, and 90th percentiles of the seasonal rainfall total have accumulated. Trends are assessed using the robust Spearman rank correlation analysis and the Kendall–Theil slope estimator. Principal component analysis is used to extract the dominant spatial patterns and these are correlated with antecedent land–ocean–atmosphere variables. Results show a significant delay in the beginning, peak, and closing stages of the monsoon in recent decades. The results also show a decrease in rainfall during July and a corresponding increase in rainfall during August and September. Relating these attributes of the summer rainfall to antecedent winter–spring land and ocean conditions leads to the proposal of the following hypothesis: warmer tropical Pacific sea surface temperatures (SSTs) and cooler northern Pacific SSTs in the antecedent winter–spring leads to wetter than normal conditions over the desert Southwest (and drier than normal conditions over the Pacific Northwest). This enhanced antecedent wetness delays the seasonal heating of the North American continent that is necessary to establish the monsoonal land–ocean temperature gradient. The delay in seasonal warming in turn delays the monsoon initiation, thus reducing rainfall during the typical early monsoon period (July) and increasing rainfall during the later months of the monsoon season (August and September). While the rainfall during the early monsoon appears to be most modulated by antecedent winter–spring Pacific SST patterns, the rainfall in the later part of the monsoon seems to be driven largely by the near-term SST conditions surrounding the monsoon region along the coast of California and the Gulf of California. The role of antecedent land and ocean conditions in modulating the following summer monsoon appears to be quite significant. This enhances the prospects for long-lead forecasts of monsoon rainfall over the southwestern United States, which could have significant implications for water resources planning and management in this water-scarce region.
An integer division method using characteristics of integer reciprocals

An algorithm for integer division that is based on the periodic nature of reciprocals of odd integers is presented. The method consists of the determination of the value in one period of the reciprocal of odd divisor d (referred to as the B-sequence), multiplication of the dividend D by this value to produce D', and the division of D' by 2/sup n/-1, where n is the length of the B-sequence. The generation of the B-sequence and division by 2/sup n/-1 are addressed in detail. Proofs of correctness are provided for both processes. The algorithms are suitable for VLSI implementation. An approach to implementation using systolic arrays is presented. >
7.3.3 Using Measurement to Assure Operational Safety, Suitability, and Effectiveness (OSS&E) Compliance for the C2 Product Line

Air Force Policy Directive 63–12, Assurance of Operational Safety, Suitability, and Effectiveness, establishes the Air Force requirement to assure operational safety, suitability, and effectiveness (OSS&E) through a system's operational life. Electronic Systems Center (ESC) of Air Force Materiel Command (AFMC) is responsible to provide this assurance for each Command and Control (C2) system developed, procured, operated, maintained, modified, or employed. This paper discusses the role measurement must play in the OSS&E assurance process, and offers guidance to develop effective measures. While specific measures must be adapted for each system, the concepts needed to develop effective measures are the same. A combination of product, process, and performance measures may serve as indicators to show the project manager the overall project OSS&E status. These could include trends that show compliance being maintained or in jeopardy, or the positive (or negative) effects of a particular course of action. Example measures are presented to reinforce the concepts being presented.