cssi/SciSciGPT-SciSciNet huggingface dataset:
Age-Related Changes in the Photoperiodic Response of Siberian Hamsters

Previous studies indicate that as Siberian hamsters (Phodopus sungorus) age, they may lose their ability to show gonadal regression in response to short days. In one study, hamsters that regressed on short days early in life failed to regress when exposed to short days a second time later in life. Thus, Siberian hamsters may experience age-related deficits in photoresponsiveness or may be incapable of regressing twice. In the present study, we attempted to discriminate between these possibilities by examining patterns of gonadal regression in hamsters transferred back and forth from long (16L:8D) to short days (6L:18D) every 6.5, 13, or 26 wk for a 2-yr period. A control group was maintained on long days and had enlarged gonads throughout the entire study. Hamsters alternating between 26 wk of long and short days exhibited complete gonadal regression during their initial but not during their second exposure to short days. Hamsters alternated between long and short days every 13 or 6.5 wk showed regression two to three times, respectively. After about 52 wk of age, the majority of animals in both groups did not regress when exposed to short days. Taken together, the results of this experiment indicate that male Siberian hamsters 1) can exhibit at least two rounds of short-day-induced gonadal regression and 2) fail to regress on short days after about 1 yr of age.
Autocrine loops with positive feedback enable context-dependent cell signaling

We describe a mechanism for context-dependent cell signaling mediated by autocrine loops with positive feedback. We demonstrate that the composition of the extracellular medium can critically influence the intracellular signaling dynamics induced by extracellular stimuli. Specifically, in the epidermal growth factor receptor (EGFR) system, amplitude and duration of mitogen-activated protein kinase (MAPK) activation are modulated by the positive-feedback loop formed by the EGFR, the Ras-MAPK signaling pathway, and a ligand-releasing protease. The signaling response to a transient input is short-lived when most of the released ligand is lost to the cellular microenvironment by diffusion and/or interaction with an extracellular ligand-binding component. In contrast, the response is prolonged or persistent in a cell that is efficient in recapturing the endogenous ligand. To study functional capabilities of autocrine loops, we have developed a mathematical model that accounts for ligand release, transport, binding, and intracellular signaling. We find that context-dependent signaling arises as a result of dynamic interaction between the parts of an autocrine loop. Using the model, we can directly interpret experimental observations on context-dependent responses of autocrine cells to ionizing radiation. In human carcinoma cells, MAPK signaling patterns induced by a short pulse of ionizing radiation can be transient or sustained, depending on cell type and composition of the extracellular medium. On the basis of our model, we propose that autocrine loops in this, and potentially other, growth factor and cytokine systems may serve as modules for context-dependent cell signaling.
Techniques for minimizing and balancing I/O during functional partitioning

Recent work has demonstrated numerous benefits of functionally partitioning a behavioral process into mutually exclusive subprocesses before synthesizing each process into a custom digital-hardware processor. A key problem during partitioning is minimizing the input/output (I/O) pins or wires between processors. The traditional structural partitioning approach is strongly restricted by such I/O. We previously showed that the new approach of functional partitioning eases this restriction. We now demonstrate a further relaxation of the I/O restriction by introducing the FunctionBus interprocessor bus and the port-calling functional transformation. The FunctionBus allows choice of any size for internal I/O by trading off I/O size for performance, while port calling allows distribution of external I/O almost arbitrarily among modules. We describe experiments showing large I/O reductions through these techniques, with only small performance penalties.
MANAGEMENT: MUCH MORE INTERDISCIPLINARY THAN YOU THINK

The discipline of Management is typically associated with schools of business and is thought to be a professional or pre-professional degree. Hence, it is commonly separated from the Liberal Arts and any discussions about interdisciplinary topics. However, the roots of management are in Economics, Psychology and other disciplines with ties across many different subjects. In this paper I go through management textbooks and read the primary sources used for the content covered in various chapters. A significant amount of the citations for the material is from academic journals in Psychology, great works by Philosophers, classic writings by Economists and other areas in the Social Sciences. This paper illustrates the interdisciplinary nature of a subject that is not traditionally thought to be one.
Sensor Andrew: Ubiquitous wide campus sensing exploitation

Summary form only given. Carnegie Mellon University has a long history of innovation in campus wide availability of networking infrastructures. In the early 80psilas, Andrew was inaugurated as a campus wide (wired) networking infrastructure that in a few years networked faculty, staff, and students (undergraduate and graduate) all across campus - offices, dormitories, room facilities. In 1995, Carnegie Mellon embarked on a similar effort with wireless Andrew that from 6 access points in 1995 went to hundreds and then thousands of access points in a couple of years providing global campus wireless coverage (see IEEE Personal Communications Magazine, February 1996). Both infrastructures served as campus wide testbeds to experiment and develop emergent technologies at the time. In 2006, Carnegie Mellon, through CenSCIR, the newly formed Center for Sensed Critical Infrastructure Research, has launched Sensor Andrew, a campus wide living laboratory to deploy thousands of sensing platforms of various types, providing campus wide instrumentation coverage, and supporting the breadth of applications users feel the need to develop. This keynote will overview Sensor Andrew, and describe its hardware, software, and middleware infrastructure, as well as some of the applications that are being developed. We will also address the issues related to what to do with the large amounts of data collected by an application supported on Sensor Andrew, how to process these data in a distributed fashion, and how to infer from the localized sensor information global understanding and global behaviors.
Mobility Among Business Faculty

A survey reveals a high incidence of job mobility among business faculty, with many changing academic positions after serving only 2 years. Job changes appear to be motivated by economic reasons, b...
Location, location, location: residence, wealth, and the quality of medical care in Delhi, India.

ABSTRACT: There are seventy medical care providers within walking distance of every household in Delhi. However, inequalities in health outcomes persist among the rich and poor, which might reflect...
High-performance visible-UV CCD imagers for space-based applications

focusing on work on large device formats, improvements in quantum efficiency, and reduction of CCD degradation in the natural space-radiation environment. Research was based on a 420 x 420-pixel frame-transfer device and a new 1024 x 1024-pixel device. To obtain high quantum efficiency from the visible into the UV, a technology for making back-illuminated versions of these devices is being developed. Quantum efficiencies greater than 80 percent in the 500-800 nm band have been obtained with a SiO antireflection coating. Particular attention is given to the problem of charge-transfer inefficiency degradation caused by energetic protons in space-based systems. It is shown that CCDs can be significantly hardened to radiation effects by a combination of special buried channel potential profiles and operation at temperatures around 150 K, where the trap sites created by the protons have emission times much longer than the clock periods.
Parents' Management of Their Children's Education within the Home, at School, and in the Community: An Examination of African-American Families Living in Poverty.

Using parents' answers to open-ended questions, we examine variation in parents' management of their children's education within the home, at school, and in the community as a function of whether their children were experiencing academic success or academic problems. Within the home, parents of high achievers used more specific strategies to help their children with their schoolwork and had more supportive conversations with their children than parents of low achievers. At their children's school, parents of high achievers not only were more involved but had different reasons for their involvement than parents of low achievers. In the community, more parents of high achievers explicitly engaged their children in activities to support their achievement than parents of low achievers. Implications for parents, schools, and communities are discussed.
The Mesh and the Spermatic Cord

The fibrotic reaction of polypropylene mesh after tension- free (TFR) inguinal herniorrhaphy causing vasal obstruction has been implicated as the reason for infertility in a group of patients presented in a recent paper by Shin and colleagues [1]. The purpose of this presentation is to examine the controversial subject of infertility and inguinal hernia repair and analyze some of the currently available evidence.
Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model.

Objective: To evaluate the potential of multiparametric spectroscopic photoacoustic imaging using oxygen saturation, total hemoglobin, and lipid content to differentiate among four different breast histologies (normal, hyperplasia, ductal carcinoma in situ (DCIS), and invasive breast carcinoma) in a transgenic mouse model of breast cancer development. Materials and Methods: Animal studies were approved by the Institutional Administrative Panel on Laboratory Animal Care. Mammary glands (n=251) of a transgenic mouse model of breast cancer development (FVB/N-Tg(MMTV-PyMT)634Mul) were imaged using B-mode ultrasound and spectroscopic photoacoustic imaging, analyzed for oxygen saturation, total hemoglobin, and lipid content, and processed for histological analysis. Statistical analysis was performed using one-way ANOVA, two-sample t-tests, logistic regression, and ROC analysis. Results: Eighty-two normal, 12 hyperplastic, 96 DCIS, and 61 invasive breast carcinoma mammary glands were analyzed. Based on spectroscopic photoacoustic imaging, the oxygen saturation of hyperplasia (50.6%), DCIS (43.0%), and invasive carcinoma (46.2%) significantly increased compared to normal glands (35.5%, P <0.0001), while both total hemoglobin (P<0.01), and lipid content (P<0.0008) significantly decreased with advancing histology. In differentiating normal and hyperplasia from DCIS and invasive breast carcinoma, multiparametric imaging of oxygen saturation, lipid content, and raw photoacoustic signal at 750 nm provided an AUC value of 0.770. Conclusion: Multiparametric spectroscopic photoacoustic imaging is feasible and allows detection of differences in concentration of tissue chromophores among different histologies in a transgenic mouse model of breast cancer development.
Engaging E-Learning in Virtual Worlds: Supporting Group Collaboration

Current e-learning environments do not provide sufficient support for group collaboration. The absence of the visual identification of the users makes effective collaboration in e-learning very difficult. This paper argues that virtual worlds (VW) possess the necessary tools to foster effective group collaboration for e-learning initiatives. The use of avatars, the support of verbal and non-verbal communications and creative capabilities offered in VWs are suggested as the key elements that promote effective group learning.
Measurement of H2O2 Broadening Parameters near 7.8 μm with a Shock Tube

Hydrogen peroxide is an important intermediate species in the combustion of hydrogen and hydrocarbon-based fuels at low temperatures (850-1200K) and elevated pressures. Part of the reason for the importance of H2O2 is that the molecule produces a considerable amount of hydroxyl radicals prior to the ignition event, so it is important to have a good understanding of the kinetic reactions involving this species. In the past, a few groups–including the authors of this work–have investigated hydrogen peroxide at these elevated temperatures by using shock tubes [1]-[3]. The shock tube is an ideal experiment for investigating combustion chemistry at elevated pressures and temperatures of interest to this study. Measurements have also been made at temperatures below 900 K within static cells [4]-[6]. It is important to know how this species behaves experimentally in a combustion environment to develop and validate chemical kinetics models.
Arctic Climate Systems Analysis

This study began with a challenge from program area managers at Sandia National Laboratories to technical staff in the energy, climate, and infrastructure security areas: apply a systems-level perspective to existing science and technology program areas in order to determine technology gaps, identify new technical capabilities at Sandia that could be applied to these areas, and identify opportunities for innovation. The Arctic was selected as one of these areas for systems level analyses, and this report documents the results. In this study, an emphasis was placed on the arctic atmosphere since Sandia has been active in atmospheric research in the Arctic since 1997. This study begins with a discussion of the challenges and benefits of analyzing the Arctic as a system. It goes on to discuss current and future needs of the defense, scientific, energy, and intelligence communities for more comprehensive data products related to the Arctic; assess the current state of atmospheric measurement resources available for the Arctic; and explain how the capabilities at Sandia National Laboratories can be used to address the identified technological, data, and modeling needs of the defense, scientific, energy, and intelligence communities for Arctic support.
Land-Use Patterns and Spatially Dependent Ecosystem Services: Some Microeconomic Foundations

Land-Use Patterns and Spatially Dependent Ecosystem Services: Some Microeconomic Foundations
The Catholic Bishops in the U.S. Public Arena: Changing Prospects under Pope Francis

The public profile of the Roman Catholic bishops of the United States results not simply from their own interventions in political life, but from the broad array of actions and actors within “public Catholicism” broadly conceived. This article assesses the contemporary profile of the American bishops from this broad angle, particularly in light of new dynamics under the papacy of Francis I. It does so by documenting public Catholicism’s presence in ecclesial institutions, other public institutions, and lay-centered social movements (particularly faith-based community organizing) and via a case study of the healthcare reform debate around the State Children’s Health Insurance Program and the Affordable Care Act. Cultural and institutional factors shaping Catholic public presence are analyzed in three dimensions of social life: institutional leadership; authority dynamics within the Church; and the culture of prayer, spirituality, and worship in parishes. Finally, the conclusion discusses the key dynamics likely to shape the future of public Catholicism in America.
Methanol/Trimethoxysilane Azeotrope Separation Using Pressure-Swing Distillation

The process to produce trimethoxysilane involving the reaction of methanol with silicon produces a mixture of unreacted methanol and trimethoxysilane that requires separation so that the methanol can be recycled back to the reaction section. This binary mixture forms a maximum-boiling homogeneous azeotrope of 28.65 mol % methanol at 1 bar and 87.94 °C. The composition of the azeotrope changes fairly significantly with pressure, so separation into high-purity component streams is viable using pressure-swing distillation. The purpose of this paper is to design a pressure -swing distillation process for this separation that uses heat integration of the two columns, which operate at different pressures and different temperatures. One of the unique features of this system is the use of a vacuum column in which tray pressure drop has a significant effect on the optimum selection of design parameters such as the number of trays. The specifications for the bottoms compositions must be adjusted as pressures are ch...
Modification of Impulse Generation During Pirouette Turns With Increased Rotational Demands

This study determined how dancers regulated angular and linear impulse during the initiation of pirouettes of increased rotation. Skilled dancers (n = 11) performed single and double pirouette turns with each foot supported by a force plate. Linear and angular impulses generated by each leg were quantified and compared between turn types using probability-based statistical methods. As rotational demands increased, dancers increased the net angular impulse generated. The contribution of each leg to net angular impulse in both single and double pirouettes was influenced by stance configuration strategies. Dancers who generated more angular impulse with the push leg than with the turn leg initiated the turn with the center of mass positioned closer to the turn leg than did other dancers. As rotational demands increased, dancers tended to increase the horizontal reaction force magnitude at one or both feet; however, they used subject-specific mechanisms. By coordinating the generation of reaction forces between legs, changes in net horizontal impulse remained minimal, despite impulse regulation at each leg used to achieve more rotations. Knowledge gained regarding how an individual coordinates the generation of linear and angular impulse between both legs as rotational demand increased can help design tools to improve that individual's performance.
A correlation between thrombotic disease and a specific fibrinogen abnormality (A alpha 554 Arg-->Cys) in two unrelated kindred, Dusart and Chapel Hill III

For the first time, a correlation between a specific fibrinogen abnormality and the clinical symptoms of thrombosis has been found in unrelated families. These abnormal fibrinogens have been designated Dusart and Chapel Hill III. The abnormal fibrinogen Chapel Hill III was identified previously in a patient with thrombotic disease. We purified fibrinogen from small aliquots of patient and normal plasmas by a simple, rapid procedure. Coomassie stained sodium dodecyl sulfate- polyacrylamide gel electrophoresis (SDS-PAGE) analysis demonstrated that fibrinogen Chapel Hill III contained several high molecular weight forms in addition to the two forms seen with normal fibrinogen. Immunoblot analysis of Chapel Hill III fibrinogen demonstrated that essentially all the high molecular weight forms react with antiserum to albumin. Immunoblot analysis of plasmin digests of Chapel Hill III fibrinogen demonstrated that albumin is linked to the C-terminus of the A alpha chain. Using DNA analysis, we found that the patient is heterozygous for a single base change, resulting in the substitution A alpha Arg 554-->Cys. This is the same change identified in fibrinogen Dusart. The Dusart family members who are heterozygous for this substitution also suffer from recurrent thrombotic disorders.
Study on Method of Relay Protection Action Analysis Based on Wave Replay

Protection actions of 220 kV Bai-sha I and II transmission lines during the trip-out accident of No.1 main transformer in 500kV Baise substation are analyzed..The method how to use the wave replay to analyze relay protection actions is described. It is pointed out that wave replay is an important method to validate relay protection actions.
Perception of Foreign Accent in Spontaneous L2 English Speech

This study compared English and Mandarin Chinese listeners′ assessments of foreign accent in spontaneous English spoken by speakers of eight L1 languages.Compared with listeners whose native language is English,Mandarin Chinese listeners perceived lower degree of foreign accent than native listeners,and were less sensitive to Mandarin and Cantonese accents than to the other accents,especially French,Spanish,and Russian.Acoustic analysis suggests that English and Mandarin Chinese listeners relied on different cues in the perception of Foreign Accent in L2 English.
Simulation of Vehicle Tire Bouncing and Methods to Examine and Analyze Tire Envelops Based on the CATIA Digital Prototype Module

This paper mainly uses the CATIA digital prototype(DMU) module to simulate and analyze the front Mcpherson suspension of the car(including the front subframe and front anti-roll bar).First we should establish simplified suspension model according to the Mcpherson suspension components and movement characteristics.The second we can establish the simplified kinematic simulation based on the prototype model applying reasonable kinematic pair and a driving command.Through the motion simulation to create wheel limit envelopes,then analyze the dynamic gap.
Stem rust resistance in Aegilops tauschii germplasm

Aegilops tauschii Coss., the D genome donor of hexaploid wheat, Triticum aestivum L., has been used extensively for the transfer of agronomi- cally important traits to wheat, including stem rust resistance genes Sr33, Sr45, and Sr46. To identify potentially new stem rust resistance genes in A. tauschii germplasm, we evaluated 456 nonduplicated accessions deposited in the USDA National Small Grains Collection (Aber- deen, ID) and the Wheat Genetic and Genomic Resources Center collection (Kansas State University, Manhattan, KS), with races TTKSK (Ug99), TRTTF, TTTTF, TPMKC, RKQQC, and QTHJC of Puccinia graminis Pers.:Pers. f. sp. tritici Eriks. & E. Henn. Ninety-eight acces- sions (22%) were identifi ed as resistant to race TTKSK. A broad range of resistant infection types (; to 2+) were found in reaction to race TTKSK. Resistance was signifi cantly associ- ated among most of the races in pairwise com- parisons. However, resistance was largely race specifi c. Only 12 of the accessions resistant to race TTKSK were also resistant to the other fi ve races. Results from this germplasm screening will facilitate further studies on the genetic char- acterization of accessions with potentially novel sources of resistance to race TTKSK.
Chemically Enhanced Wastewater Treatment: An Appropriate Technology for the 1990’s

Recent experience with chemical enhancement in primary sedimentation shows that marked improvement both in primary removal efficiency and plant flow capacity can be achieved without creating excessive sludge quantity or processing problems. The small amounts of metal salts and polymers added as coagulants and flocculants are effective in treatment plant upgrading. Chemically enhanced primary treatment can be a stand-alone, single-stage treatment process. Alternatively, it can be part of a two-stage process in which a small biological treatment unit is designed to take advantage of the high solids and BOD removal capability of the chemical primary stage.
Study on the reform and improvement of the medical device registration system in China

Based on the theories of the Government Regulation and Administrative Licensure, aiming at the current situations of medical device registration system in China, some policy suggestions for future reform and improvement were provided as follows. (1) change the concepts of medical device registration administration. (2) perfect the regulations of medical device registration administration. (3) reform the medical device review organizational system. (4) Optimize the procedure of review and approval. (5) set up and maintain a professional team of review and approval staff. (6) reinforce the post-marketing supervision of medical devices. (7) foster and bring into play of the role of non-government organizations.
Prevention and treatment for parents of young children in military families.

More than 2.2 million parents of dependent children have served in the post-September 11th era wars in Afghanistan and Iraq. Given the duration of these conflicts, it is likely that a majority of military-connected children and adolescents first experienced parental deployment during critical periods of early childhood development when parent–child attachments are being formed and strengthened. In the context of deployment separation and reintegration, very young children are especially vulnerable as they and their families cope with a multitude of stressors associated with the deployment cycle. As the needs and strengths of military parents and children have been increasingly documented, the adjustment of the at-home parent and children has been identified as a critical factor in the well-being of the service member in theater. Parenting programs have emerged or been adapted to respond to military populations to meet the needs of both the service member parent and the family. These prevention and intervention programs have been designed to mitigate the long-term impacts of deployment-related stressors on young children and to build upon the inherent strengths, creativity, and capacities of military families. In this chapter, we first review what we know about how very young children experience deployment. We then detail the roles and importance of parenting and coparenting throughout the deployment cycle, and describe selected parenting programs designed to support families with very young children. Finally, we make the case for relationship-based approaches when working with military families. A brief description of Strong Families Strong Forces is offered as a military-specific reflective parenting program aimed at improving parent–young child relationships and reducing parenting stress.
Antislavery and Capitalism

In accounting for the destruction of British slavery it is necessary to emphasize how closely it was embedded in its social and economic world even when it chose to shift or change one element of that world. Without the context of a rising industrial order there would have been no social leverage available to destroy one of the original components of the old order. Yet linking the rise of antislavery to the evolution of capitalism alone leaves us far short of explaining the dynamic of abolitionism. I have taken issue with accounts whose point of departure is a capitalist political domination of antislavery, its socially controlling methods, its ideological hegemony, or its artful transference of one form of social domination into another. I have attempted to change the frame of reference by emphasizing abolitionism’s broad social base and the heuristic utility of viewing its history as a power struggle rather than a display of hegemonic symbol manipulation.
The Relationship Between Parenteral Nutrition and Central Line–Associated Bloodstream Infections: 2009–2014

Background: Parenteral nutrition (PN) administered via central venous catheter has been identified as an independent risk factor for central line–associated bloodstream infections (CLABSIs). The aim of this study was to provide an updated description of the relationship between PN and CLABSI and assess temporal trends in CLABSI rates for individuals who received PN from 2009–2014, after the Centers for Medicare & Medicaid declared CLABSI a “never event.” Methods: Using data obtained from all adult patient discharges between January 1, 2009, and December 31, 2014, from 2 affiliated hospitals in a large health system in New York City, univariate and multivariate analyses were performed to examine the relationship between PN and CLABSIs as well as temporal trends. Results: Among 38,674 patients with central lines, 3517 developed CLABSIs and 767 patients were prescribed PN. PN was an independent risk factor for developing CLABSI among our patients (odds ratio [OR], 2.65; 95% confidence interval [CI], 2.20–3.1...
Fecal microbiota transplantation for Clostridium difficile infection in patients with ileal pouches.

Background:Clostridium difficile infection (CDI) in patients with ileal pouch-anal anastomosis (IPAA) has been increasingly recognized. The aim of this study was to evaluate the outcome of fecal microbiota transplantation (FMT) in patients with pouch and CDI. Methods: All consecutive patients that underwent FMT for CDI from 2012 to 2016 were extracted from our IRB-approved, prospectively maintained Registry of Pouch Disorders. The primary outcome was negative stool tests for Clostridium difficile after FMT and the secondary outcomes were symptomatic and endoscopic responses. Results: A total of 13 patients were included in this study, with 10 being Caucasian males (76.9%). All patients had underlying ulcerative colitis for J pouch surgery. After a mean of 2.8±0.8 courses of antibiotic treatments was given and failed, 22 sessions of FMT were administered with an average of 1.7±1.1 sessions each. Within the 22 sessions, 16 were given via pouchoscopy, 4 via esophagogastroduodenoscopy and 2 via enemas. All patients tested negative on C. difficile polymerase chain reaction (PCR) after the initial FMT with a total of 7/12 (58.3%) documented patients showed symptomatic improvements and 3/11 (27.3%) patients showed endoscopic improvement according to the modified Pouchitis Disease Activity Index. During the follow-up of 1.2±1.1 years, there were a total of five patients (38.5%) that had recurrence after the successful initial treatment and four of them were successfully treated again with FMT. Conclusions: FMT appeared to be effective in eradication of CDI in patients with ileal pouches. However, FMT had a modest impact on endoscopic inflammation and recurrence after FMT and recurrence was common.
Judicial Bypass for Minors Seeking Abortions in Arkansas Versus Other States

Objectives. To describe demographic characteristics and abortion timing of minors in Arkansas who obtained an abortion through a judicial bypass, and to contrast the frequency of judicial bypass in other states in the United States.Methods. We used individual-level data on all abortions to minors (n = 2624) performed in Arkansas from 2005 to 2014 and aggregated data from 10 additional states on abortions obtained through a judicial bypass. We characterized correlates of the judicial bypass and its association with the timing of abortion.Results. Minors in Arkansas who used the courts were more likely to be 17 years of age, nonresidents of Arkansas, Hispanic, and with fewer previous pregnancies than their younger, resident, non-Hispanic White, and multigravida counterparts; 7.7% of abortions to minors were obtained via a bypass in 11 states, but only 2% if Texas and Arkansas are excluded.Conclusions. The demographics of minors who obtain an abortion through a judicial bypass differ significantly from those...
Influence of Phosphorus on Nitrogen Fertilizer Requirement of Melampodium leucanthum (Blackfoot Daisy) Grown in Perlite-Vermiculite Medium

Abstract We determined the influence of N and P fertilizers on growth and tissue N concentration of container grown blackfoot daisy (Melampodium leucanthum Ton. & Gray), a resource-efficient native landscape herbaceous perennial for the southwestern United States. Regression equations derived from the data indicated that maximum growth could be obtained by application of 166 mg N/liter (ppm) in irrigation water if 30 mg P/liter were also applied. However, near maximum growth was obtained with 100 mg N/liter at the 30 mg P/liter level. Fifteen mg P/liter in irrigation water were not adequate for maximum growth. Tissue nitrogen concentrations in whole plants should be > 1.7% for growth not to be limited by N.
The rationality of nonsense: Intensity of meaning of non-referential verbal units

Measures of meaningfulness have been developed from two contrasting orientations: associative meaning and connotative or mediational meaning. The present study was designed to explore further the relationships of these orientations through the use of non-referential (nonsense) verbal units. High and low association value nonsense syllables were rated by 42 Ss, 25 female and 17 male, on 20 semantic differential scales. Utilizing Jenkins’ concept of polarization as a measure of intensity of meaning, an analysis of variance yielded a significant difference between the ratings. Further analysis indicated that the difference was due, not to the association value, but to the differential ratings of male and female subjects. It was argued that the theoretical bases of associative meaning could not account for the findings. The communalities of phonic inputs and meanings are suggested as important variables.
Abstract 17441: Social Support is Important, but Self-Care Confidence is the Key for Better Treatment Adherence in Patients With Chronic Heart Failure Admitted With an Acute Exacerbation

Introduction: Adherence to treatment is crucial to improve outcomes in patients with heart failure (HF). Social support is associated with adherence, but the mechanism of this association is not we...
Breakout Session: Mapping the Copyright Constellation: Charting Campus Partners to Create Copyright Instruction Your Students Will Care About.

This is a report on North Carolina librarians Will Cross, Molly Keener, and Lillian Rigling’s presentation at the 2017 Kraemer Copyright Conference where they advocated building campus partnerships to teach students about U.S. copyright law in a way that is both meaningful and pertinent. Each presented a case study in which presenters worked with faculty to develop course integrated copyright instruction. Two of these were successes while the third produced uneven results.
Letters of Schutz to Felix Kaufmann

Kaufmann was an older close friend of Schutz who urged him to study Husserl’s works, they engaged in that study together, and Schutz thereby became a phenomenologist. They were colleagues together at the New School for Social Research and their friendship continued in the USA until Kaufmann died. It is unfortunate that these are all of Schutz’s letters to his friend. Schutz’s memorial essay for Kaufmann is printed in CP IV.
A Large Sample Study of the Estimate for the Survival Distribution in Cox’x Regression Model

Regression models for survival analysis with censored observations have been used quite extensively in the past few years. One of the more widely used models is the one suggested by Cox (1972), which assumes that the hazard rate is related to set of covariated denoted by the vector \(\underset{\raise0.3em\hbox{$\smash{\scriptscriptstyle\thicksim}$}}{z} = \left( {{z_1}, \ldots ,{z_p}} \right)\) as follows: $$\lambda \left( {t|\mathop{z}\limits_{ \sim } } \right) = {\lambda _{o}}\left( t \right)\exp \left( {{\beta _{1}}{z_{1}} + \ldots + {\beta _{p}}{z_{p}}} \right)$$ where λo(t) denotes an arbitrary underlying hazard function.
THE Ah LOCUS. GENETIC DIFFERENCES IN TOXIC AND TUMORIGENIC RESPONSE TO FOREIGN COMPOUNDS

The Ah locus represents a complex “cluster” of genes controlling the induction of numerous drug-metabolizing enzyme “activities” by polycyclic aromatic compounds. The major regulatory gene product is a cytosolic receptor similar in many ways to the steroid receptors. Structural gene products include two (and probably many more) distinctly different forms of cytochrome P1-450. Allelic differences at the Ah locus have been shown to be associated in the mouse with increased individual risk for cancer, mutation, DNA binding of reactive metabolites, drug toxicity, birth defects, and enhanced detoxification. These differences presumably reflect increases or decreases in the steady-state level of reactive intermediates in target tissues–because of quantitative increases in P1-450 and/or qualitative changes in the metabolite profile generated by newly induced P1-450. The genetically “responsive” individual who is at increased risk for cancer caused by subcutaneous or topical or intratracheal polycyclic hydrocarbons is at decreased risk for toxicity of the bone marrow and leukemia caused by oral benzo[a]pyrene, (when compared with the genetically “nonresponsive” individual receiving the same dose of the same xenobiotic). In other words, tissue sites in direct contact with the carcinogen develop cancer in responsive animals because of induced P1-450; tissues in distant sites of the body may develop malignancy in nonresponsive animals because more carcinogen reaches that tissue due to decreased P1-450 induction all over the body and therefore decreased detoxification. Not only the dose but the route of administration is therefore very important in the interpretation of data from tumorigenesis or toxicity experiments involving P1-450 inducers such as polycyclic hydrocarbons.
The Christian Tradition and Hobbes’ Civil Theology

At this point it is necessary to introduce a second major theme with some extensive development to deepen the analysis of Hobbes’ and later thinkers’ view of salvation and civil religion. This particular theme is based on the value of the Christian tradition of philosophical anthropology as the matrix of thought and a necessary precondition for any further philosophical questioning and reflection.The essential assumption of the idea of a philosophical tradition is that common or shared human experience over an extent of time has an unimpeachable claim to some degree of validity. Human wisdom and insight into experience are not limited to any particular person or country or century, and therefore one cannot claim all of the past to be in error. Disagreement with particular ideas current in the past or held by particular persons in the past is, of course, not only possible but probably essential to the growth of the tradition, but only on the condition that the vital principle of the tradition is accepted. It is this vital principle, this agreed-upon foundation of the meaning of human existence, that is the basis of dialogue among philosophers of all centuries. The tradition is an organism that grows and develops only so long as the source of its life remains intact.
RF generation in the DARHT Axis-II beam dump

We have occasionally observed radio-frequency (RF) electromagnetic signals in the downstream transport (DST) of the second axis linear induction accelerator (LIA) at the dual-axis radiographic hydrodynamic testing (DARHT) facility. We have identified and eliminated some of the sources by eliminating the offending cavities. However, we still observe strong RF in the range 1 GHz t0 2 GHz occurring late in the {approx}2-{micro}s pulse that can be excited or prevented by varying the downstream tune. The narrow frequency width (<0.5%) and near exponential growth at the dominant frequency is indicative of a beam-cavity interaction, and electro-magnetic simulations of cavity structure show a spectrum rich in resonances in the observed frequency range. However, the source of beam produced RF in the cavity resonance frequency range has not been identified, and it has been the subject of much speculation, ranging from beam-plasma or beam-ion instabilities to unstable cavity coupling.
Radial Stresses in Curved Glulam Beams

A method for estimating the maximum radial tension and compression stresses in curved glulam beams of rectangular cross section is presented. The recommended precedure is based on a parametric study of beams representing a broad range of the key geometric variables and subject to pure bending and uniformly distributed loading. A trapezoidal finite element method was utilized to carry out the analysis of the beams. The overestimation of the radial tension stresses resulting from the simplied assumptions made in the current design procedure for the case of uniformly distributed loading is illustrated. The recommended method for estimation of the radial stresses for the practical loading case of uniformly distributed loading, improves the competitive position of this structural system.
Gifts and Their Giving

In this allegorical revisiting of the Christian story of Peter, James, and John giving a beggar not what he requested but what they discerned that he needed, I frame a window of vocational commitment. Through this window I invite the reader to view the landscape of an apparently insurmountable gap between a therapy companion’s desire and my best gifts.
CRISPR RNA-guided DNA cleavage by reconstituted Type I-A immune effector complexes

Diverse CRISPR-Cas immune systems protect archaea and bacteria from viruses and other mobile genetic elements. All CRISPR-Cas systems ultimately function by sequence-specific destruction of invading complementary nucleic acids. However, each CRISPR system uses compositionally distinct crRNP [CRISPR (cr) RNA/Cas protein] immune effector complexes to recognize and destroy invasive nucleic acids by unique molecular mechanisms. Previously, we found that Type I-A (Csa) effector crRNPs from Pyrococcus furiosus function in vivo to eliminate invader DNA. Here, we reconstituted functional Type I-A effector crRNPs in vitro with recombinant Csa proteins and synthetic crRNA and characterized properties of crRNP assembly, target DNA recognition and cleavage. Six proteins (Csa 4-1, Cas3″, Cas3', Cas5a, Csa2, Csa5) are essential for selective target DNA binding and cleavage. Native gel shift analysis and UV-induced RNA-protein crosslinking demonstrate that Cas5a and Csa2 directly interact with crRNA 5' tag and guide sequences, respectively. Mutational analysis revealed that Cas3″ is the effector nuclease of the complex. Together, our results indicate that DNA cleavage by Type I-A crRNPs requires crRNA-guided and protospacer adjacent motif-dependent target DNA binding to unwind double-stranded DNA and expose single strands for progressive ATP-dependent 3'-5' cleavage catalyzed by integral Cas3' helicase and Cas3″ nuclease crRNP components.
Teaching Mechanics Using Kinesthetic Learning Activities.

As students learn physics, they are often required to reason about the behavior of macroscopic and microscopic phenomena, and to synthesize prior knowledge from several different areas of physics to construct understanding of new ideas. This can be a tremendously difficult cognitive task for novice students, especially when the unfamiliar phenomena described are potentially microscopic or abstract. Therefore, it can be very helpful for physics instructors to develop and employ pedagogical techniques that help students to visualize and to reason productively about these concepts. A particularly effective strategy uses Kinesthetic Learning Activities (KLAs).
Abstract TP183: Burden of Disability Among Stroke Survivors in the United States Between 2005 and 2017

Aims: The aims of the present study are to assess burden of disability among stroke survivors: 1) in women compared to men; 2) by age group; 3) race &4) study period. Methods: We used the clinical ...
Metastatic Microenvironments Alter Breast Cancer Aggressiveness and Response to Therapeutics

Abstract : Metastases account for nearly all deaths associated with advanced breast cancer and diagnosis of metastases results in less than a 3% survival rate over 20 years. There are five molecularly distinct subtypes of breast cancer, and it is unknown if primary tumors and metastases are genetically identical or if they differ in the expression of genes that facilitate cancer spread and survival. The purpose of this project is to identify approaches to prevent the spread of cancer cells and to inhibit the growth of cancer cells growing as metastases by utilizing overlapping in vitro, in vivo, and in silico models. Herein we identify that gene expression profiles of cancer cells and endothelial cells are largely maintained, regardless of the environment they are in. We also identify that the different breast cancer subtypes are predisposed to metastasize to different vital organs.
The Population Health Value Framework: Creating Value by Reducing Costs of Care for Patient Subpopulations With Chronic Conditions

Author(s): Gupta, Reshma; Roh, Lily; Lee, Connie; Reuben, David; Naeim, Arash; Wilson, James; Skootsky, Samuel A | Abstract: PROBLEM:With the growth in risk-based and accountable care organization contracts, creating value by redesigning care to reduce costs and improve outcomes and the patient experience has become an urgent priority for health care systems. APPROACH:In 2016, UCLA (University of California, Los Angeles) Health implemented a system-wide population health approach to identify patient populations with high expenses and promote proactive value-based care. The authors created the Patient Health Value framework to guide value creation: (1) identify patient populations with high expenses and reasons for spending; (2) create design teams to understand the patient story; (3) create custom analytics and spending-based risk stratification; and (4) develop targeted care pathways based on spending risk tiers. Primary care patients with three chronic conditions-dementia, chronic kidney disease (CKD), and cancer-were identified as high-cost subpopulations. OUTCOMES:For each patient subpopulation, a multispecialty, multidisciplinary design team identified reasons for spending and created care pathways to meet patient needs according to levels of spending risk. Larger, lower-risk cohorts received necessary but less intensive interventions while smaller, higher-risk cohorts received more intensive interventions. Preliminary analyses showed a 1% monthly decrease in inpatient bed day utilization among dementia patients (incident rate ratio [IRR] 0.99, P l .03) and a 2% monthly decrease in hospitalizations (IRR 0.98, P l .001) among CKD patients. NEXT STEPS:Use of the PHV framework is expanding across other high-cost subpopulations with chronic conditions. UCLA Health is using the framework to organize care across specialties, build capacity, and grow a culture for value.
A Computationally Efficient Surrogate-Based Reduction of a Multiscale Comill Process Model

Particle breakage in milling operations is often modeled using population balance models (PBMs). A discrete element method (DEM) model can be coupled with a PBM in order to explicitly identify the effect of material properties on breakage rate. However, the DEM-PBM framework is computationally expensive to evaluate due to high-fidelity DEM simulations. This limits its application in continuous process modeling for dynamic simulation, optimization, or control purposes. The current work proposes the use of surrogate modeling (SM) techniques to map mechanistic data obtained from DEM simulations as a function of processing conditions. To demonstrate the benefit of the SM-PBM approach in developing integrated process models for continuous pharmaceutical manufacturing, a comill-tablet press model integration utilizing the proposed framework is presented. The SM-PBM approach is in excellent agreement with the DEM-PBM approach to predict particle size distributions (PSDs) and dynamic holdup, with a maximum sum of square errors of 0.0012 for PSD in volume fraction and 0.93 for holdup in grams. In addition, the time taken to run a DEM simulation is in the order of days whereas the proposed hybrid model takes few seconds. The SM-PBM approach also enables comill-tablet press model integration to predict tablet properties such as weight and hardness. The proposed hybrid framework compares well with a DEM-PBM framework and addresses limitations on computational expense, thus enabling its use in continuous process modeling.