cssi/SciSciGPT-SciSciNet huggingface dataset:
A Fast, 3MV Marx Generator for Megavolt Oil Switch Testing with an Integrated Abramyan Network Design

The University of Missouri-Columbia has a new test facility online to study oil breakdown of enhanced and uniform gaps. The test facility includes a 3 MV Marx generator consisting of 30 stages with a total capacitance of 1.6 nF. With an inductance of 4.6 muH, the pulser is designed to deliver the 3 MV output pulse with a risetime (10-90%) of < 10 ns with a peaking gap. The output polarity of the pulser can be easily reversed for switch and dielectric testing. The configurations tested include a large electrode gap spacing with point-ball electrodes. The test results from these experiments will be reported along with a conceptual design for a simple modification which will allow a rectangular pulse to be applied to the sample under test. The conceptual design for the pulser includes an Abramyan network designed to extend the output at 1-1.5 MV to a pulse width of 1 mus. By reverse-discharging a fraction of the stages in parallel with an inductor of an optimized value, the pulse width increases dramatically at a minimal cost to the pulse amplitude. The cost-effective addition of a single inductor will be compared to the efficiencies of traditional pulse-forming networks. This paper will also discuss the Abramyan network versatility with respect to altering pulse amplitude and width using a simple modification to the inductor. Benefits for switch testing will be discussed along with test results.
Pseudocytoplasmic Inclusions in Tongue Epithelium of Dogs with Canine Parvovirus-2 Infections

demiology, pathophysiology, and treatment. Mt Sinai J Med 61: 329–335. 22. Perrin J, Cosmetatos I, Gallusser A, et al.: 1993, Clostridium difficile associated with typhlocolitis in an adult horse. J Vet Diagn Invest 5:99–101. 23. Riegler M, Sedivy R, Pothoulakis C, et al.: 1995, Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro. J Clin Invest 95:2004–2011. 24. Riley TV, O’Neill GL, Bowman RA, Golledge CL: 1994, Clostridium difficile-associated diarrhoea: epidemiological data from Western Australia. Epidemiol Infect 113:13–20. 25. Ryden EB, Lipman NS, Taylor NS, et al.: 1991, Clostridium difficile typhlitis associated with cecal mucosal hyperplasia in Syrian hamsters. Lab Anim Sci 41:553–558. 26. Samore MH, Bettin KM, DeGirolami PC, et al.: 1994, Wide diversity of Clostridium difficile types at a tertiary referral hospital. J Infect Dis 170:615–621. 27. Wilson KH: 1993, The microecology of Clostridium difficile. Clin Infect Dis 16(Suppl 4):S214–S218. 28. Wolfhagen MJHM, Torensma R, Fluit AC, Verhoef J: 1994, Toxins A and B of Clostridium difficile. FEMS Microbiol Rev 13:59–64.
“Quiet Ego” Functioning: The Complementary Roles of Mindfulness, Authenticity, and Secure High Self-Esteem

Brown, Ryan, and Creswell (this issue) provide an impressive and thorough review of mindfulness from multiple perspectives and traditions. They elucidate the Buddhist roots of contemporary conceptu...
Influence of mood state on capacity to consent to research in patients with bipolar disorder.

Objectives: Experts have debated the ability of patients with bipolar illness to consent to research participation when manic. We compared 25 euthymic bipolar and 26 manic bipolar patients in their understanding of three hypothetical studies of varying complexity. Methods: Hypothetical studies were presented as written informed consent forms, which were reread up to three times. Questions included assessment of hypothetical study purposes, procedures, risks and benefits, and voluntariness of participation. Results: After adjusting for educational level, subjects with mania had lower mean understanding scores for all three hypothetical studies compared to euthymic subjects on initial assessment. By the end of Trial 3 of each hypothetical study, there were no significant differences between groups. The proportion of subjects with mania who met predetermined pass criteria for sufficient understanding was lower than the proportion of euthymic subjects on initial assessment of the first hypothetical study, but not the other hypothetical studies (odds ratio = 0.24; 95% confidence interval = 0.07–0.8; p = 0.02). Both groups exhibited an increase in the pass proportion by the end of the third trial for each hypothetical study with no significant differences between groups. Conclusions: We conclude that subjects with mania exhibited significantly poorer levels of understanding of relevant information in hypothetical research consent forms compared to euthymic subjects when initially presented with research information. The improvement in manic patients’ understanding scores with the iterative review of consent forms suggests that many manic patients may be able to consent to research protocols containing an educational intervention as a part of the informed consent process.
Use of adaptive resolution for better CMAC learning

The quantization of the input space affects the performance of cerebellar model arithmetic computer (CMAC)-based systems. The conventional CMAC uses equal-size quantization without considering the variation of the target function in different areas. The new scheme presented is capable of adaptively changing the input quantization through the use of the so-called mapping functions. For a fixed number of blocks and elements, larger blocks and elements are used for the areas with less variation in control signal. Memory is efficiently used. Through the repeated learning and mapping function updating, better learning results can be achieved. Simulation results for a single-variable case are encouraging. >
Can transcranial ultrasound and microbubble therapy ever enter the mainstream in acute stroke therapy

Ischemic stroke remains the third most common cause of death in the USA. It is a leading cause of long-term major ­disability and approximately 700,000 new cases are recorded every year.Despite num...
Pancreatitis associated with an adenovirus in a rhesus monkey.

A juvenile Rhesus monkey died suddenly while being conditioned for tissue culture studies. A diagnosis of necrotizing pancreatitis associated with adenovirus was made on the basis of the demonstration by electron microscopy of paracrystalline arrays of viral particles and granular and fibrillar inclusions in necrotic pancreatic acinar cells. This is the first description of necrotizing pancreatitis in a nonhuman primate. Adenovirus should be considered in the etiology of pancreatitis in nonhuman primates. Necrotizing pancreatitis, which has been reported infrequently in animals other than the dog (5), usually has not been caused by infection. Recently, however, it has been reported in foals with natural adenovirus infection (9) and in young chickens experimentally inoculated with adenovirus (3). Ex­ perimental viral pancreatitis caused by reovirus (II) and coxsackievirus B3 (4) in mice has also been described. CRAIGHEAD (1) has written an excellent review of viral pancreatitis in man and animals. We have not found previous reports of necrotizing viral pancreatitis in nonhuman primates. This report describes the gross, light, and electron microscopic findings of necrotizing pancreatitis associated with an adeno­ virus in a Rhesus monkey that died while being conditioned.
Matthaeus Judex's Condemnation of Princely Censorship of Theologians' Publications

Just as God condemns and curses the Roman Antichrist, so without any doubt at all he also curses the new Caesaropapacy … in which governmental officials station themselves in God's temple and puff themselves up against God and the church … as they compose and promulgate new decrees contrary to what Christ has ordained for his ministry, and then decide to subject [Christ's ministers] to the punishment of exile and condemnation.
Fabrication of full coverage restorations for existing removable partial dentures

Abstract A technique has been described for the fabrication of full coverage restorations for existing removable partial dentures. This method requires that the patient be deprived of the removable prosthesis during the fabrication of the fixed replacement unit. Clearly, this may not always be possible or desirable; however, when it is possible, the end result outweighs the inconvenience to the patient.
Catabolite repression in the gram‐positive bacteria: Generation of negative regulators of transcription

Operons subject to catabolite repression (CR) in the gram-positive bacteria appear to be transcriptionally regulated by negative acting catabolite repressors. Cis elements within the promoter regions of a few CR operons have been identified as the target sequences for these repressors. It has also been proposed that sequences internal to the transcriptional unit may represent targets for recognition of the operons as catabolite repressible. The precise mechanism(s) of regulation have yet to be worked out. © 1993 Wiley-Liss, Inc.
A Trial of an All-Terrain Vehicle Safety Education Video in a Community-Based Hunter Education Program.

Purpose: All-terrain vehicle (ATV) injury is an increasingly serious problem, particularly among rural youth. There have been repeated calls for ATV safety education, but little study regarding optimal methods or content for such education. The purpose of this study was to determine if an ATV safety video was effective in increasing ATV safety knowledge when used in a community-based statewide hunter education program. Methods: During the baseline phase, surveys focusing on ATV safety were distributed to students in the Arkansas hunter safety program in 2006. In the intervention phase a year later, an ATV safety video on DVD was provided for use in required hunter education courses across Arkansas. The same survey was administered to hunter education students before and after the course. Findings: In the baseline phase, 1,641 precourse and 1,374 postcourse surveys were returned and analyzed. In the intervention phase, 708 precourse and 694 postcourse surveys were completed. Student knowledge of ATV safety after watching the video was higher than in preintervention classes. Knowledge of appropriate helmet usage increased from 95% to 98.8% (P Language: en
Antimicrobial resistance in beef and dairy cattle production

Observational studies of cattle production systems usually find that cattle from conventional dairies harbor a higher prevalence of antimicrobial resistant (AMR) enteric bacteria compared to organic dairies or beef-cow operations; given that dairies usually use more antimicrobials, this result is not unexpected. Experimental studies have usually verified that application of antimicrobials leads to at least a transient expansion of AMR bacterial populations in treated cattle. Nevertheless, on dairy farms the majority of antibiotics are used to treat mastitis and yet AMR remains relatively low in mastitis pathogens. Other studies have shown no correlation between antimicrobial use and prevalence of AMR bacteria including documented cases where the prevalence of AMR bacteria is non-responsive to antimicrobial applications or remains relatively high in the absence of antimicrobial use or any other obvious selective pressures. Thus, there are multi-factorial events and pressures that influence AMR bacterial populations in cattle production systems. We introduce a heuristic model that illustrates how repeated antimicrobial selection pressure can increase the probability of genetic linkage between AMR genes and niche- or growth-specific fitness traits. This linkage allows persistence of AMR bacteria at the herd level because subpopulations of AMR bacteria are able to reside long-term within the host animals even in the absence of antimicrobial selection pressure. This model highlights the need for multiple approaches to manage herd health so that the total amount of antimicrobials is limited in a manner that meets animal welfare and public health needs while reducing costs for producers and consumers over the long-term.
A Principal-Agent Model for Regional Pest Control Adoption

Investigating the underlying producer characteristics associated with regional pest control adoption revealed an interesting proposition. Early adopting producers of firm-specific techniques with characteristics including higher education, more specialized operations, and larger sized business units are dissatisfied with a regional pest control technique. This study provides an explanation of the proposition based on a principal-agent model, Empirical support for the proposition is also presented by developing a multinomlal Iogit model for predicting producers’ dissatisfaction with boll weevil eradication.
Working with OpusXpress: methods for high volume oocyte experiments

OpusXpress is a semi-automated system for high throughput voltage clamp recording from Xenopus oocytes. We participated in the development process for this system and were the only laboratory to field test a prototype. Subsequently, we obtained an early production model that we have used on a regular basis for the last seven years, conducting many thousands of experiments, publishing extensively, and carrying out collaborative research in drug discovery. In this article, we relate our experience with the OpusXpress recording system and large volume oocyte handling. We provide our standard operating procedures and outline the organization of our successful team. Some of our advice is specific to researchers fortunate enough to have access to an OpusXpress system, but most of it is applicable to any group using Xenopus oocytes for the heterologous expression of ion channels.
Synthesis and Characterization of Nanostructured Niobium and Molybdenum Nitrides by a Two-Step Transition Metal Halide Approach

Nanosized NbNx (1.64>x>1.33) and MoNx (1.32>x>0.77) crystallites were synthesized at a relatively low temperature (≥600°C) through ammonolysis and nitridation of the corresponding metal chlorides. The ammonolysis reaction in anhydrous chloroform at room temperature and the nitridation mechanism during subsequent heat treatment was investigated using Fourier transform infrared spectroscopy, X-ray diffraction (XRD), thermogravimetric (TG), and mass spectroscopy analysis. The effects of the synthesis parameters on the stoichiometry, structure, specific surface area, density, and electronic conductivity of the final nitrides were studied using TGA, XRD, N2 adsorption, high-resolution transmission microscopy, helium pycnometry, and four-point probe technique. Preliminary electrochemical responses of the obtained nitrides were studied using cyclic voltammetry to explore their possible use as electrochemical capacitors.
Iatrogenic Aortocoronary Arteriovenous Fistula Percutaneous Management of a Surgical Complication

Iatrogenic aortocoronary arteriovenous fistula (ACAVF) resulting from placement of an arterial graft to a cardiac vein is a rare complication of coronary artery bypass grafting (CABG) [(1,2)][1]. Most patients present post-operatively with angina as a result of residual ischemia that is due to
Active Learning in the Undergraduate Classroom:: A Journal-Club Experience Designed to Accentuate Course Content

Students in the natural sciences should be prepared as undergraduates to read and apply concepts from the scientific literature. I describe a strategy that enforced the necessity to deliver high volumes of content while incorporating an active-learning technique. Students were assigned to read and discuss articles from the scientific literature that complemented content being delivered via traditional lecture. Students were encouraged to participate by coming to class prepared with written questions, and discussion was directed by instructor-prepared prompts. Students were assessed via low-stakes assignments based primarily on participation. This teaching method has proved effective, as verbally reported by past students who are currently enrolled in graduate programs. These students report feeling more prepared than their peers to discuss and learn from the scientific literature.
Modeling the Voltage Dependence of Electrochemical Reactions at Solid-Solid and Solid-Liquid Interfaces in Batteries

Electrochemical reactions at electrode/electrolyte interfaces are critically dependent on the total electrochemical potential or voltage. In this presentation, we briefly review ab initio molecular dynamics (AIMD)-based estimate of voltages on graphite basal and edge planes [1], and then apply similar concepts to solid-solid interfaces relevant to lithium ion and Li-air batteries. Thin solid films on electrode surfaces, whether naturally occuring during power cycling (e.g., undesirable lithium carbonate on Li-air cathodes) or are artificially introduced, can undergo electrochemical reactions as the applied voltage varies. Here the onset of oxidation of lithium carbonate and other oxide thin films on model gold electrode surfaces is correlated with the electronic structure in the presence/absence of solvent molecules. Our predictions help determine whether oxidation first occurs at the electrode-thin film or electrolyte-thin film interface. Finally, we will critically compare the voltage estimate methodology used in the fuel cell community [2] with the lithium cohesive energy calibration method broadly applied in the battery community, and discuss why they may yield different predictions.
Explain the latent heat and specific heat of water, ammonia, and methanol with degrees of freedom

The internal energies of 0°C water and ice are considered from the perspective of degree of freedom and latent heat of fusion of water is calculated, which is in good agreement with the published value. With the same consideration, the latent heats of fusion of ammonia and methanol are calculated and the results are in reasonable agreement with the published values. This simple strategy can give specific heats of water, liquid ammonia, and methanol, which are in good agreement with known data.
The Proof is in the Proofreading

The consequences of not proofreading legal documents can be quite serious. Lawyers who submit error-ridden documents risk losing their credibility, and just one or two typos can distract a reader's attention from the intended message and, in some cases, change the meaning of the communication substantially. The article suggests various techniques for proofreading, ranging from reading aloud or backwards to using computer software to check grammar and citations.
“Skulls and bones” new member: Th17

Osteolytic bone disease mediated by osteoclasts occurs adjacent to myeloma cells suggesting a tight interrelationship between these cells and their microenvironment. In this issue of Blood, Noonan and colleagues(1) challenge this current paradigm by invoking a role for a subpopulation of T cells known as T-helper 17 (Th17) as a key regulator of bone disease in myeloma.
Beyond Dialogue to Transformative Learning: How Deliberative Rituals Encourage Political Judgment in Community Planning Processes

This paper explores the ways we learn about value in deliberative settings. In planning and many kinds of participatory processes more generally, such learning occurs not just through arguments, not just through the re-framing of ideas, not just through the critique of expert knowledge, but through transformations of relationships and responsibilities, of networks and competence, of collective memory and memberships.
Pulmonary surfactant therapy.

In 1959, not long after surfactant had been identified as critical to maintaining lung inflation at low transpulmonary pressures,1,2 Avery and Mead3 reported that saline extracts from the lungs of preterm infants with respiratory distress syndrome lacked the low surface tension characteristic of pulmonary surfactant. After several unsuccessful attempts to treat infants with respiratory distress syndrome with aerosolized surfactant,4,5 intratracheal administration of surfactant recovered from the air spaces of mature animal lungs was found to improve lung expansion and ventilation in preterm animals6–8. The clinical potential of surfactant treatment for respiratory distress syndrome was demonstrated by . . .
Efficacy of Ritodrine Hydrochloride and Magnesium Sulfate in treatment of threatened preterm labor and the relationship with Creasy high-risk factor score

Objective To study the clinical curative effect of Ritodrine Hydrochloride and Magnesium Sulfate in the treatment of threatened premature labor, and to analyze relationship of effect and Creasy high-risk factor score, to provide a reference for clinical medication guide. Methods One hundred six cases of patients with threatened premature labor in Hexian Memorial Hospital of Panyu Area in Guangzhou City from February 2013 to February 2014 were divided into two groups, the study group and the control group, each of 53 cases. Study group was treated with Ritodrine Hydrochloride therapy, the control group was treated with Magnesium Sulfate therapy. The onset time for the two drugs,prolonged time to pregnancy, neonatal survival and adverse reactions were recorded. According to the effect of preventing miscarriages, then Creasy high-risk factor score was taken, the success rate of preventing miscarriages with Creasy high-risk factor score ≥ 12 points was compared. Results After treatment, the drug onset time of study group was accelerated and prolonged time for pregnancy was significantly increased, there were significant differences(P 0.05). The success rate of preventing miscarriages in study group was significantly higher than that in the control group(96.23% vs 83.02%)(P 0.05). The birth weight and 1 min Apgar scores in study group were better than the control group, the differences were significant(P 0.05). And the incidence of adverse reactions in study group was significantly lower than the control group(3.77% vs 15.09%), there was a significant difference(P 0.05). The Creasy highrisk factor scores for patients succeeded in preventing miscarriages in both groups were significantly than those failed in preventing miscarriages(P 0.05). The rate of patients with Creasy high-risk factor score ≥ 12 points in study group was significantly higher than that in control group(26.42% vs 15.09%)(P 0.05). Conclusion The clinical efficacy of Ritodrine Hydrochloride in treatment of threatened preterm labor is superior to Magnesium Sulfate. The drug onset time is rapid, prolong gestation, it has significant effect for prolonging the time of gestational age, enhancing the survival rate of newborn babies, and adverse reactions are mild. Creasy high-risk factor score has an important impact on pregnancy outcome of threatened premature labor, for patients with threatened preterm labor and Creasy high-risk factor score ≥ 12 points, Ritodrine Hydrochloride should be given priority.
Research on theory of space conversation for subsidence control in backfilling mining and its application

Backfilling mining is an effective technical approach to solve the environmental problems and control surface subsidence caused by coal mining.The theory of space conversation for strata control in backfilling mining was put forward and the formula to calculate the surface subsidence volume was derived through the formation process analysis and the control mechanism of surface subsidence.Based on the theory,the technical approaches for subsidence control in backfilling mining were also put forward.The technical approaches were proposed,that include improving the backfilling ratio of the goaf,heightening the mechanical properties of the paste slurry and backfilling body,increasing the detention space in the overlying strata.The theory of space conversation for strata control in backfilling mining was successfully practiced in a coal mine.
HYPERSENSITIVITY: “DOC, AM I ALLERGIC TO MY IMPLANT?”

Abstract There is controversy regarding the clinical significance of metal hypersensitivity in total knee arthroplasty (TKA). Given the current state of the art, metal hypersensitivity, if it exists at all, is a diagnosis of exclusion. Clinical presentation may involve a cutaneous response, but current diagnostic methods do not have robust clinical validation and should be used with caution. The two most commonly used tests include cutaneous patch testing and in vitro lymphocyte transformation testing. Initially, conservative management is indicated and other more common causes of a symptomatic total knee replacement should be fully explored. In rare cases, device removal may be undertaken but this should be considered a last resort. Pre-operative testing prior to a primary total joint replacement may be helpful when there′s a patient-reported history of intolerance to jewelry or of an allergic reaction to a prior metal implant, but routine lab screening is not supported by the literature.
Design of selective emitter profiles for high efficiency solar cells under manufacturing technology constraints

Fabrication and analysis of a 21% efficient baseline n-PERT cell in this paper revealed that its performance was limited by its large J 0 values on the front and back side, highlighting the need for a bifacial structure with selective emitters to decrease J 0 . To determine the practical efficiency limit of such a cell, Sentaurus 2-D modeling was conducted using doping profiles previously reported for high efficiency cells. The maximum efficiency was calculated to be 22.7% with self-alignment of the contacts to the heavily doped regions. Modeling was then conducted to investigate the losses incurred from the required alignment tolerances associated with the heavily doped region and metal contacts made with today's large-scale manufacturing equipment. Through careful design of the selective emitter and back surface field doping profiles, we show that for 50 μm wide metal contacts screen printed on a 300 μm wide heavily doped region on a 10 Ω-cm base wafer with bulk lifetime of 3 ms, the loss can be decreased by 0.65%, with practical screen-printed cell efficiencies approaching 22.5%. Projected future technology improvements show efficiencies up to 23% are possible with this structure.
The psoriasis-associated deletion of late cornified envelope genes LCE3B and LCE3C has been maintained under balancing selection since Human Denisovan divergence

A common, 32kb deletion of LCE3B and LCE3C genes is strongly associated with psoriasis. We recently found that this deletion is ancient, predating Human-Denisovan divergence. However, it was not clear why negative selection has not removed this deletion from the population. Here, we show that the haplotype block that harbors the deletion (i) retains high allele frequency among extant and ancient human populations; (ii) harbors unusually high nucleotide variation (π, P < 4.1 × 10−3); (iii) contains an excess of intermediate frequency variants (Tajima’s D, P < 3.9 × 10−3); and (iv) has an unusually long time to coalescence to the most recent common ancestor (TSel, 0.1 quantile). Our results are most parsimonious with the scenario where the LCE3BC deletion has evolved under balancing selection in humans. More broadly, this is consistent with the hypothesis that a balance between autoimmunity and natural vaccination through increased exposure to pathogens maintains this deletion in humans.
Creating a Coastal National Elevation Database (CoNED) for Science and Conservation Applications

ABSTRACT Thatcher, C.A.; Brock, J.C.; Danielson, J.J.; Poppenga, S.K.; Gesch, D.B.; Palaseanu-Lovejoy, M.E.; Barras, J.A.; Evans, G.A., and Gibbs, A.E., 2016. Creating a Coastal National Elevation Database (CoNED) for science and conservation applications. In: Brock, J.C.; Gesch, D.B.; Parrish, C.E.; Rogers, J.N., and Wright, C.W. (eds.), Advances in Topobathymetric Mapping, Models, and Applications. Journal of Coastal Research, Special Issue, No. 76, pp. 64–74. Coconut Creek (Florida), ISSN 0749-0208. The U.S. Geological Survey is creating the Coastal National Elevation Database, an expanding set of topobathymetric elevation models that extend seamlessly across coastal regions of high societal or ecological significance in the United States that are undergoing rapid change or are threatened by inundation hazards. Topobathymetric elevation models are raster datasets useful for inundation prediction and other earth science applications, such as the development of sediment-transport and storm surge models. ...
Functional Characterization of HLA SNPs Associated with Risk of Follicular Lymphoma

Abstract 1551 Background: Genome-wide association studies (GWAS) suggest an important role of genetic variation in the etiology of follicular lymphoma (FL). Multiple susceptibility alleles in the human leukocyte antigen (HLA) Class I and II regions on chromosome 6p21.33–32 have been identified for FL, including rs10484561 (OR = 1.95, P = 1.12×10−29) and rs2647012 SNP (OR = 0.64, P = 2×10−21) (Conde et al., Nat Gen, 2010; Smedby et al. Plos Gen, 2011). Moreover, high-resolution HLA typing using next-generation sequencing has identified a number of HLA alleles associated with FL including the extended haplotype DRB1*01:01—DQA1*01:01—DQB1*05:01 that is in complete linkage disequilibrium with rs10484561 (D9=1), and DRB1*15-DQA1*01-DQB1*06, which is highly correlated with rs2647012 (D9=1) (Skibola et al., Tissue Antigens, 2012). We hypothesized that these SNPs or protein variants may alter immune responses to specific antigens and influence tumor development through effects on gene expression or protein structure. To gain a further understanding of the mechanisms involved, here we explored the effects of HLA alleles on expression at the transcriptional and protein level. Methods: HLA-DRB1, HLA-DQB1 and HLA-DQA1 mRNA expression and protein levels were measured by RT-qPCR and flow cytometry, respectively, in 40 lymphoblastoid cell lines (Coriell) where wild type and variant rs10484561 and rs2647012 genotypes were compared. Results: HLA-DQB1 gene expression changes were significantly associated with rs2647012 genotypes, where the presence of the variant (protective) allele correlated with higher HLA-DQB1 transcript levels. Flow cytometry with HLA-specific antibodies and pan-HLA antibodies (against DR/DQ/DP) also confirmed that the variant rs2647012 allele was associated with higher HLA-DQB1 protein levels. No significant changes were observed in HLA-DRB1, HLA-DQB1 or HLA-DQA1 transcript or protein levels when comparing rs10484561 wild type versus variant alleles. Conclusions: We did not detect significant differences in transcript or surface protein levels based on rs10484561 genotypes. These findings suggest that the increased risk of FL associated with rs10484561 that is in high LD with the HLA-DRB1*0101—DQA1*0101—DQB1*0501 extended haplotype is not due to transcriptional modulation, but may be due to effects on protein structure. On the other hand, the protective rs2647012 variant was associated with higher HLA-DQB1 mRNA and protein expression, suggesting that rs2647012 or a SNP in LD influences FL risk through effects on gene expression. We are currently testing the influence of additional FL risk alleles in the 6p21.3 region on HLA gene and protein expression, as well as investigating whether FL risk alleles alter HLA expression in other cell types. Disclosures: No relevant conflicts of interest to declare.
Medical and Surgical Interventions Available Before a Periviable Birth

Periviable birth contributes disproportionately to perinatal morbidity and mortality. By analyzing the most relevant outcomes after a preterm birth some information can be provided on the potential benefit of interventions. This article discusses surgical and medical interventions that may offer neonatal benefit including cerclage, amniocentesis, progesterone, antenatal corticosteroids, magnesium sulfate for neuroprotection, and tocolysis. Cervical cerclage has the greatest promise at reducing morbidity and mortality related to periviable birth even though it may not reduce the overall preterm birth rate. The use of antenatal corticosteroids, magnesium sulfate, progesterone, and tocolytics may also improve outcome. Studies specifically evaluating these interventions are needed.
Corpus-based, statistical goal recognition

Goal recognition for dialogue systems needs to be fast, make early predictions, and be portable. We present initial work which shows that using statistical, corpus-based methods to build goal recognizers may be a viable way to meet those needs. Our goal recognizer is trained on data from apian corpus and then used to determine the agent's most likely goal based on that data. The algorithm is linear in the number of goals, and performs very well in terms of accuracy and early prediction. In addition, it is more easily portable to new domains as does not require a hand-crafted plan library.
Quantum nano-photonic devices based on rare-earth ions

I present our progress towards developing optical quantum memories based on photonic crystal cavities fabricated in rare-earth-doped crystals. These devices exhibit large spontaneous emission rate enhancement, enabling optical control of single rare-earth ion quantum bits.
Assessment of KU Libraries’ Slavic & Eurasian Collection: Purpose, Process, and Potential

ABSTRACTThis paper discusses collection-related assessment projects that were conducted in 2013–2014 by the University of Kansas (KU) Libraries’ International Collections librarians in cooperation with librarians for assessment and resource sharing. While these assessment projects were undertaken in an effort to strengthen the library reports for KU’s Title VI National Resource Center (NRC) grant applications, which were submitted by KU’s area studies centers, the results also have implications for collection development work. The article begins with background about the NRC grants and explains why and how these assessment projects developed. Highlights of results from each assessment project are presented in the following order: assessment of the research needs of area studies faculty and graduate students at KU; citation patterns (2005–2013) of area studies, and more specifically, Slavic and Eurasian studies faculty at KU; and resource sharing data for the Slavic and Eurasian collection 2011–2013. The a...
Developing a Scaling Strategy That Fits Your Ecosystem

Building a new house is a complicated process, which can take dozens of skilled workers to complete. I have embarked on projects to build a new home for my family four times, and each experience has been totally unique. All of the projects had highly satisfactory outcomes, but the paths we took to get to those outcomes varied enormously. The way we functioned was highly influenced by the “ecosystem” in which we were operating at the time we began the projects. The whole process was affected by economic, social, and political conditions in the local markets, the changing status of our own economic resources, the shifting tastes and needs of our family members, and the differing philosophies and skills of the various architects, designers, decorators, landscapers, gardeners, bankers, builders, contractors, and subcontractors who teamed up with us. One house was built from a stock plan, another was a brainstorm of a young, aspiring architect who specified everything beforehand, and another was created as we went along, adapting it to our own whims and those of the builder/designer, who would constantly come up with new ideas for features and materials as he browsed the Internet or searched the overstocked supplies of lumberyards and junkyards.
Lasso detection using partial-state caching

We study the problem of finding liveness violations in real-world asynchronous and distributed systems. Unlike a safety property, which asserts that certain bad states should never occur during execution, a liveness property states that a program should not remain in a bad state for an infinitely long period of time. Checking for liveness violations is essential to ensure that a system will always make progress in production. The violation of a liveness property can be demonstrated by a finite execution where the same system state repeats twice (known as lasso). However, this requires the ability to capture the state precisely, which is arguably impossible in real-world systems. For this reason, previous approaches have instead relied on demonstrating a long execution where the system remains in a bad state. However, this hampers debugging because the produced trace can be very long, making it hard to understand. Our work aims to find liveness violations in real-world systems while still producing lassos as a bug witness. Our technique relies only on partially caching the system state, which is feasible to achieve efficiently in practice. To make up for imprecision in caching, we use retries: a potential lasso, where the same partial state repeats twice, is replayed multiple times to gain certainty that the execution is indeed stuck in a bad state. We have implemented our technique in the P# programming language and evaluated it on real production systems and several challenging academic benchmarks.
Transcriptional Regulation in Prostate Cancer

Prostate cancer development involves corruption of the normal prostate transcriptional network, following deregulated expression or mutation of key transcription factors. Here, we provide an overview of the transcription factors that are important in normal prostate homeostasis (NKX3-1, p63, androgen receptor [AR]), primary prostate cancer (ETS family members, c-MYC), castration-resistant prostate cancer (AR, FOXA1), and AR-independent castration-resistant neuroendocrine prostate cancer (RB1, p53, N-MYC). We use functional (in vitro and in vivo) as well as clinical data to discuss evidence that unveils their roles in the initiation and progression of prostate cancer, with an emphasis on results of chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq).
Reduction of EMI Noise Due to Nonideal Interleaving in a 100 kW SiC PV Converter

A Grid-tied inverter utilizing wide bandgap devices can achieve higher switching frequency resulting in a power filter with reduced size and weight. However, the increased switching frequency may lead to more switching harmonics entering the electromagnetic interference (EMI) frequency range, which will increase the size of EMI filter. Interleaving paralleled converters can cancel some of the switching harmonics and reduce the size of EMI filter. However, nonideal interleaving will deteriorate the harmonic canceling effect. In this research, the nonideal effects are found to be from the small mismatch of the pulsewidth of the interleaving legs and the mismatch of the impedance between the interleaving legs. A modulation method is proposed to completely eliminate the pulsewidth mismatch. Compared with other solutions, the proposed method does not require the information of filter parameters, neither gate driver synchronization, and nor a special function block of the digital controller. The proposed modulation was implemented on a 150 MHz digital signal processor and a 100 MHz field-programmable gate array, and was experimentally verified on a 100 kW parallel coupled SiC PV inverter prototype.
Lung cancer treatment costs, including patient responsibility, by disease stage and treatment modality, 1992 to 2003.

Abstract Objectives The objective of this analysis was to estimate costs for lung cancer care and evaluate trends in the share of treatment costs that are the responsibility of Medicare beneficiaries. Methods The Surveillance, Epidemiology, and End Results (SEER)-Medicare data from 1991–2003 for 60,231 patients with lung cancer were used to estimate monthly and patient-liability costs for clinical phases of lung cancer (prediagnosis, staging, initial, continuing, and terminal), stratified by treatment, stage, and non-small- versus small-cell lung cancer. Lung cancer-attributable costs were estimated by subtracting each patient's own prediagnosis costs. Costs were estimated as the sum of Medicare reimbursements (payments from Medicare to the service provider), co-insurance reimbursements, and patient-liability costs (deductibles and “co-payments” that are the patient's responsibility). Costs and patient-liability costs were fit with regression models to compare trends by calendar year, adjusting for age at diagnosis. Results The monthly treatment costs for a 72-year-old patient, diagnosed with lung cancer in 2000, in the first 6 months ranged from $2687 (no active treatment) to $9360 (chemo-radiotherapy); costs varied by stage at diagnosis and histologic type. Patient liability represented up to 21.6% of care costs and increased over the period 1992–2003 for most stage and treatment categories, even when care costs decreased or remained unchanged. The greatest monthly patient liability was incurred by chemo-radiotherapy patients, which ranged from $1617 to $2004 per month across cancer stages. Conclusions Costs for lung cancer care are substantial, and Medicare is paying a smaller proportion of the total cost over time.
A Neutron Radiographic Facility on a Research Reactor and Some Results Obtained in NDT

A neutron radiographic facility on a research reactor and its characteristics are briefly described. A collimator of the facility is placed in a horizontal thermal column channel of 150mm in diameter. The converters of Gd or Dy metal foils, or painted Gd2O2S paper plate combined respectively with x-film are used as image detector and indicator. Some performances of the system, such as resolution and sensitivity, have experimentally been tested. Some practical applications of the facility and better results obtained in NDT for the quality inspecting and controlling of several industrial products are illustrated.
Non-ocular Tumors

In the management of retinoblastoma, it is important to remember that there is an entire patient to treat – not just an intraocular tumor. Children with heritable retinoblastoma who have a germ-line mutation in RB1 have an increased risk of developing a second malignancy. All familial cases, all bilateral cases, and approximately 15 % of unilateral cases fall into this category. The most common secondary malignancies are sarcomas, melanoma, and brain tumors. The association of retinoblastoma and an intracranial neuroblastic malignancy, known as “trilateral retinoblastoma,” most often involves the pineal gland (“pineoblastoma/pinealoblastoma”) but may also involve parasellar and suprasellar regions ( Chap. 20) [1–3]. The increased risk of developing second, non-ocular malignancies for survivors of heritable retinoblastoma is estimated to be 20 times higher than the general population [4].
Power-Efficient Data Modulation for All-Mechanical ULF/VLF Transmitters

Miniaturized and power-efficient ULF/VLF (0.330 kHz) transmitters are desirable for underground and undersea wireless communications. Transmitters based on rotating permanently-polarized dipoles are promising for such applications. This paper proposes a power-efficient data modulation scheme for such mechanical transmitters based on continuous-frequency FSK (CF-FSK). Theoretical analysis and simulations show that 8-ary CF-FSK is optimal since it minimizes average mechanical torque for a given bit rate. Model predictive control (MPC) of a permanent magnet (PM) motor is proposed for robust implementation of the data modulation scheme. Preliminary results from an experimental prototype are also presented.
Unveiling the Mechanism of Highly-Efficient Nonlinear Responses from Film-Coupled Plasmonic Structures

We investigate the mechanism of highly efficient nonlinear responses from dielectric materials in a tiny gap of less than 7 nm between a gold film and metallic nanostructures, which offers potential for on-chip nonlinear devices.
A Terminating and Confluent Term Rewriting System for the Pure Equational Theory of Quandles

This article presents a term rewriting system for the first-order equational theory of quandles that is both terminating and confluent. As a consequence, it has unique normal forms and so encodes a decision procedure for quandle identities. However, the problem of computing a normal form for this term rewriting system is, in worst case, EXP hard.
"Game on!" Teaching gamification principles for library instruction to health sciences information professionals using interactive, low-tech activities and design-thinking modalities.

Background: Gamification is correlated with increased motivation and engagement of learners and is increasingly being incorporated into library instruction. Opportunities for librarians to learn and practice principles of gamification can be helpful for those desiring to integrate gamification into instruction. This report describes the development and delivery of an interactive special content session at MLA ’18, the 2018 Medical Library Association annual meeting in Atlanta, Georgia, focusing on principles of low-tech game design for health sciences library classroom instruction. Case Presentation: The special content session, titled “Design, Play, Learn: A Special Content Session to Design a Game for Database Instruction,” was designed and delivered using multimodal instruction (e.g., flipped classroom, didactic component, active learning) that also incorporated principles of design thinking. A pre- and post-survey was given to all participants at the beginning and end of the session to measure confidence and desire to incorporate gamification into instruction and as a formative feedback indicator for instructors. Participants reported increased confidence and desire to use games for library instruction after participating in the session. A selection of games were uploaded to a shared content folder designed for course participants as an ongoing repository for ideas and communication. Conclusions: For librarians who are interested in integrating principles of gamification into library instruction, attending a relatively short hands-on workshop can facilitate learning and confidence around prototyping and creating games for use in library instruction. We intend to improve upon the workshop and offer it again in additional contexts, based on direct observations of the session and participant feedback.
Surgical Treatment of Patients With Dual Hip and Spinal Degenerative Disease: Effect of Surgical Sequence of Spinal Fusion and Total Hip Arthroplasty on Postoperative Complications.

STUDY DESIGN Retrospective study. OBJECTIVE To determine how lumbar spinal fusion-total hip arthroplasty (LSF-THA) operative sequence would affect THA outcomes. SUMMARY OF BACKGROUND DATA Outcomes following THA in patients with a history of lumbar spinal degenerative disease and fusion are incompletely understood. METHODS The PearlDiver Research Program (http://www.pearldiverinc.com) was used to identify patients undergoing primary THA. Patients were divided into four cohorts: 1) Primary THA without spine pathology, 2) remote LSF prior to hip pathology and THA, and patients with concurrent hip and spinal pathology that had 3) THA following LSF, and 4) THA prior to LSF. Postoperative complications and opioid use were assessed with multivariable logistic regression to determine the effect of spinal degenerative disease and operative sequence. RESULTS Between 2007 and 2017, 85,595 patients underwent primary THA, of whom 93.6% had THA without lumbar spine degenerative disease, 0.7% had a history of remote LSF, and those with concurrent hip and spine pathology, 1.6% had THA prior to LSF, and 2.4% had THA following LSF. Patients with hip and lumbar spine pathology who underwent THA prior to LSF had significantly higher rates of dislocation (aOR = 2.46, P < 0.0001), infection (aOR = 2.65, P < 0.0001), revision surgery (aOR = 1.91, P < 0.0001), and postoperative opioid use at 1 month (aOR: 1.63, P < 0.001), 3 months (aOR = 1.80, P < 0.001), 6 months (aOR: 2.69, P < 0.001), and 12 months (aOR = 3.28, P < 0.001) compared with those treated with THA following LSF. CONCLUSION Patients with degenerative hip and lumbar spine pathology who undergo THA prior to LSF have a significantly increased risk of postoperative dislocation, infection, revision surgery, and prolonged opioid use compared with THA after LSF. Surgeons should consider the surgical sequence of THA and LSF on outcomes for patients with this dual pathology. Shared decision making between patients, spine surgeons, and arthroplasty surgeons is necessary to optimize outcomes in patients with concomitant hip and spine pathology. LEVEL OF EVIDENCE 3.