cssi/SciSciGPT-SciSciNet huggingface dataset:
Fabrication of Nanomodified Anodes for Power Density Enhancement of Microbial Fuel Cells

Microbial fuel cells (MFCs) use microorganisms to simultaneously break down organic materials and generate electricity. One of the greatest challenges in the practical application of MFCs is to sufficiently increase their power generation. Nanomodified graphite carbon anodes were prepared for use in MFCs to enhance the electron transport from the microbes to the electrode. Nanomodification to the anodes included growth of nanoparticles and multi-walled carbon nanotubes (MWCNTs). Nanoparticles of various metals, including Au, Ni, Pd, and Fe, were synthesized through thermal annealing and Fe catalyzed MWCNTs were synthesized through chemical vapor deposition. Power density was measured in MFCs for each type of nanomodified electrodes. Significant increase in power density was observed for the MFC with anodes decorated with MWCNTs (with 50-100nm diameters).
Biofilm in milking equipment on a dairy farm as a potential source of bulk tank milk contamination with Listeria monocytogenes

The objective of this study was to assess the presence of a Listeria monocytogenes-containing biofilm in milking equipment as a potential source of bulk tank milk contamination on a dairy farm where milk contamination had been previously documented. Samples were collected from milking equipment and milking parlor premises on 4 occasions and analyzed for the presence of L. monocytogenes. Pulsed-field gel electrophoresis (PFGE) typing was conducted on L. monocytogenes isolates from the milking equipment, parlor and storage room floors, bulk tank milk, and in-line milk filters. Pieces from milk meters and rubber liners were obtained to visually assess the presence of a biofilm using scanning electron microscopy. A total of 6 (15%), 4 (25%), and 1 (6%) samples were culture-positive for L. monocytogenes in the first, second, and third sample collection, respectively. Two samples were L. monocytogenes hly PCR-positive but were culture-negative in the fourth sample collection. Combined AscI and ApaI restriction analysis yielded 6 PFGE types for 15 L. monocytogenes isolates obtained from milking equipment, parlor, bulk tank milk, and milk filters. A predominant and persistent PFGE type (PFGE type T) was observed among these L. monocytogenes isolates (9/15 isolates). Scanning electron microscopy of samples from the bottom cover of 2 milk meters showed the presence of individual and clusters of bacteria, mainly associated with surface scratches. The presence of a bacterial biofilm was observed on the bottom covers of the 2 milk meters. Prevention of the establishment of biofilms in milking equipment is a crucial step in fulfilling the requirement of safe, high-quality milk.
Analysis of the Interaction of Primate Retroviruses with the Human RNA Interference Machinery

The question of whether retroviruses, including human immunodeficiency virus type 1 (HIV-1), interact with the cellular RNA interference machinery has been controversial. Here, we present data showing that neither HIV-1 nor human T-cell leukemia virus type 1 (HTLV-1) expresses significant levels of either small interfering RNAs or microRNAs in persistently infected T cells. We also demonstrate that the retroviral nuclear transcription factors HIV-1 Tat and HTLV-1 Tax, as well as the Tas transactivator encoded by primate foamy virus, fail to inhibit RNA interference in human cells. Moreover, the stable expression of physiological levels of HIV-1 Tat did not globally inhibit microRNA production or expression in infected human cells. Together, these data argue that HIV-1 and HTLV-1 neither induce the production of viral small interfering RNAs or microRNAs nor repress the cellular RNA interference machinery in infected cells.
Using multiple metrics to assess the effects of forest succession on population status: A comparative study of two terrestrial salamanders in the US Pacific Northwest

Investigations to determine stable or source-sink animal population dynamics are challenging and often infeasible for most species due to the time and expense of mark-recapture studies and the challenge of life histories attributes that result in low detectability and low recapture probabilities. Often, managers rely solely on occupancy or relative abundance patterns to assess a species’ sensitivity to environmental changes. Greater insight into population-level responses to environmental change can be gained by consideration of a combination of readily obtainable metrics, including occupancy, relative abundance, demographic structure and body condition. We examined how these metrics can improve our understanding of population-level responses to forest disturbance, using datasets for two exemplar species of terrestrial salamanders resident to the Pacific Northwestern USA. We compared population metrics for the Del Norte salamander (Plethodon elongatus) and the Siskiyou Mountains salamander (Plethodon stormi) across the seral continuum represented by four forest age classes: pre-canopy, young, mature, and old-growth. We compared these data with those collected from reference stands in mature (P. stormi) or old-growth (P. elongatus) forest containing robust populations. P. elongatus was twice as common as P. stormi. Both occupancy and salamander counts were lowest at pre-canopy sites for both species. Although there were numerous P. elongatus detections in young forests, higher proportions of these individuals were juveniles and sub-adults when compared to populations in late-seral forests. We found a negative relationship between the proportion of immature animals and total counts at a site, indicating that the high proportion of young animals in young forest stands is likely due to dispersal of young salamanders from nearby source populations and/or low survival of adult animals in young forests. We also found reduced body condition of P. stormi populations in young forests. Our results suggest that there are costs to populations occupying early seral forests, such as skewed age class structure and reduced body condition that are indicative of sink populations. Consideration of population-level metrics beyond occupancy and relative abundance can provide important insights when assessing a species’ sustainability in managed forest landscapes.
Rotation of the lever arm of Myosin in contracting skeletal muscle fiber measured by two-photon anisotropy.

The rotation of the lever arm of myosin cross-bridges is believed to be responsible for muscle contraction. To resolve details of this rotation, it is necessary to observe a single cross-bridge. It is still impossible to do so in muscle fiber, but it is possible to investigate a small population of cross-bridges by simultaneously activating myosin in a femtoliter volume by rapid release of caged ATP. In earlier work, in which the number of observed cross-bridges was limited to ∼600 by confocal microscopy, we were able to measure the rates of cross-bridge detachment and rebinding. However, we were unable to resolve the power stroke. We speculated that the reason for this was that the number of observed cross-bridges was too large. In an attempt to decrease this number, we used two-photon microscopy which permitted observation of ∼1/2 as many cross-bridges as before with the same signal/noise ratio. With the two-photon excitation, the number of cross-bridges was small enough to resolve the beginning of the power stroke. The results indicated that the power stroke begins ∼170 ms after the rigor cross-bridge first binds ATP.
Asymptotic structure of fast dynamo eigenfunctions

The eigenfunctions of the kinematic dynamo problem exhibit complicated spatial structure when the magnetic diffusivity is small. When the base flow is spatially periodic, we may study this structure by examining the Fourier components of the eigenfunction at large wavevectors. In this regime we may seek a WKB form in terms of slowly-varying functions of wavevector. The resulting hierarchy of equations may be systematically analysed for both zero and small nonzero diffusivities.
Stress test criteria used in the conservative arm of the frisc-ii trial underdetects surgical coronary artery disease whenapplied to patients in the vanqwish trial

Abstract Objectives We sought to determine whether the stringent stress test criteria for crossover to cardiac catheterization in the conservative arm of the Fast Revascularization During Instability in Coronary Artery Disease (FRISC-II) trial subjected this strategy to a disadvantage by failing to identify patients with surgical coronary artery disease (CAD). Background In FRISC-II, an invasive strategy provided superior outcomes compared with a conservative strategy for patients with acute coronary syndromes. However, compared with the stress test criteria for crossover to catheterization in the Veterans Affairs Non–Q-Wave Infarction Strategies in Hospital (VANQWISH) trial, the FRISC-II criteria were more restrictive and did not use nuclear imaging or pharmacologic stress testing. Methods We analyzed the conservative arm of VANQWISH to identify the prevalence of surgical CAD in those patients who met the VANQWISH, but not FRISC-II, criteria for catheterization. Results Of 385 VANQWISH patients, 90 (23%) met the FRISC-II criteria for catheterization. Another 98 patients (25%) met only VANQWISH stress test criteria (60 patients by exercise and 38 by pharmacologic nuclear stress testing). Among subjects who underwent predischarge angiography, those meeting only VANQWISH stress test criteria had a high prevalence of surgical CAD (51%), comparable to patients who met FRISC-II criteria (54%, p = 0.805). Conclusions The overly stringent risk stratification protocol for conservative-arm patients in FRISC-II could have failed to identify almost as many patients with surgical CAD as it identified. A lower threshold for catheterization in the FRISC-II conservative patients might have improved their outcomes and therefore diminished the putative benefit of an invasive strategy.
Interlopers and Field Change: The Entry of U.S. News into the Field of Legal Education:

This article analyzes a process by which established organizational fields change through the incorporation of new field-level actors. Drawing on 137 in-depth interviews with U.S. law school administrators and faculty, the paper demonstrates how the U.S. News & World Report rankings of law schools gained a foothold in the field of legal education, how the dynamics of the field helped entrench the field position of USN and its rankings despite spirited opposition from key actors, and how these same dynamics explain how a seemingly minor change—the addition of a single actor to the roster of existing field actors—transformed many aspects of this field. A close examination of this new model of field change enhances field theory by underscoring how field characteristics, such as the interconnections among actors and the web of mutual influence that these imply, themselves can facilitate change. Substantively, this research provides insight into the way that those who measure, credential, or certify key field ...
Rotating objects to recognize them: A case study on the role of viewpoint dependency in the recognition of three-dimensional objects

Successful object recognition is essential for finding food, identifying kin, and avoiding danger, as well as many other adaptive behaviors. To accomplish this feat, the visual system must reconstruct 3-D interpretations from 2-D “snapshots” falling on the retina. Theories of recognition address this process by focusing on the question of how object representations are encoded with respect to viewpoint. Although empirical evidence has been equivocal on this question, a growing body of surprising results, including those obtained in the experiments presented in this case study, indicates that recognition is often viewpoint dependent. Such findings reveal a prominent role for viewpointdependent mechanisms and provide support for themultiple-views approach, in which objects are encoded as a set of view-specific representations that are matched to percepts using normalization procedures.
Effects of tea combined with high-protein meal replacement shakes on anthropometric measurements, lipid profiles, cellular biochemistry, neurochemistry, and microbial metabolism: a prospective observational study

Abstract Objective The purpose of this study was to report preliminary data on the effects of tea and high-protein meal replacement shakes on weight loss, waist-to-hip ratios, and lipid profiles in healthy subjects. Secondary analyses of urine samples assessed pre-post changes in cellular biochemistry, neurochemistry, and microbial metabolism. Methods This study used a pre-post intervention design without a control group. Thirty healthy subjects (20-60 years of age; 23 women and 7 men) participated in a 28-day diet intervention program consisting of a cleansing day and 6 restricted diet days per week. On cleansing days, the subjects drank 4 oz of tea 4 times per day with a recommendation to drink at least 64 oz of filtered water. On the restricted diet days, the subjects drank 2 high-protein meal replacement shakes, consumed one 400- to 600-cal (1674.3-2511.5 joules) meal consisting of low–glycemic index foods, and drank at least 64 oz of filtered water. Results Multiple paired t tests detected reductions in weight (6.4 lb), waist (1.9 in), and hip (1.1 in) measurements and in total cholesterol (13.3 mg/dL) and low-density lipoprotein cholesterol (11.4 mg/dL) ( P t tests detected significant increases in energy metabolism from carbohydrates and amino acids and concomitant increases in oxidative stress ( P Conclusion The data support the concept that a low–glycemic load diet intervention incorporating tea and high-protein meal replacement shakes may cause weight loss and improve lipid profiles. The significant physiologic changes from the urine samples did not reflect meaningful metabolic effects.
Hinners moves to Goddard

Noel W. Hinners, president-elect of AGU's Planetology Section and director of the Smithsonian Institution's National Air and Space Museum, has been appointed director of NASA's Goddard Space Flight Center. He succeeds A. Thomas Young, who left Goddard in late March; Leslie Meredith, AGU General Secretary, is serving as acting director until Hinners' appointment becomes effective in mid-June. Looking back at his 3 years as director of the museum, Hinners told Eos that he believed one of his most important accomplishments was to increase the historical and archival programs. His aim was to ensure that the histories of space physics, astronomy, and aeronautics will not be lost. Documentation on the evolution of ideas in these areas was scattered, improperly indexed, or nonexistent, Hinners explained, so he brought to the museum several professional historians to organize the existing information and to glean additional information through oral histories from scientists involved in such events as the International Geophysical Year.
Environmental Cold-Induced Injury

More than 650 deaths from hypothermia occur each year in the United States. Even minor deviation from normal temperature leads to important symptoms and disability. The most significant risk factors are advanced age, mental impairment, substance abuse, and injury. This article examines the incidence of hypothermia, its detrimental effect on trauma patients, and methods of rewarming the hypothermic patient. It also looks at the controversial protective role hypothermia might play in shock, organ transplantation, cardiac arrest, and brain injury. Finally, it examines cold injuries, including frostbite, chilblain, and trench foot, and makes recommendations for their treatment.
Information retrieval in medicine: The electronic medical record as a new domain

This paper presents a document-centered approach to electronic health records as an information retrieval problem. It is clear that passage retrieval researchers working in the field of information science have seen similar values in document passages as have researchers in medical informatics. Without either literature acknowledging the other, workers in both camps have identified the same potential in document structure, labels, specificity and explicit hierarchies of knowledge for signaling relevance to the reader. The National Health Information Infrastructure Initiative (http://aspe.hhs.gov/sp/nhii/) identifies academics and researchers as natural stakeholders, like clinicians and caregivers, in enabling better healthcare through better information sharing (National Committee on Vital and Health Statistics, 2003). Information science has much to contribute to the health information technology arena and to electronic health records in particular: their development, their maintenance, and most importantly their improvement to serve the needs of diverse users.
A Role for the Mannose-Sensitive Hemagglutinin in Biofilm Formation by Vibrio cholerae El Tor

While much has been learned regarding the genetic basis of host-pathogen interactions, less is known about the molecular basis of a pathogen's survival in the environment. Biofilm formation on abiotic surfaces represents a survival strategy utilized by many microbes. Here it is shown that Vibrio cholerae El Tor does not use the virulence-associated toxin-coregulated pilus to form biofilms on borosilicate but rather uses the mannose-sensitive hemagglutinin (MSHA) pilus, which plays no role in pathogenicity. In contrast, attachment of V. cholerae to chitin is shown to be independent of the MSHA pilus, suggesting divergent pathways for biofilm formation on nutritive and nonnutritive abiotic surfaces.
An Implementation of the Multidimensional Modified LMS Algorithm

An implementation of the multidimensional modified LMS algorithm is provided from its relationship to a recently developed class of lhyperstable adaptive filters.
Factors associated with computed tomography status in patients presenting with a history of chronic rhinosinusitis.

Background The diagnosis of chronic rhinosinusitis (CRS) is based upon symptomatic criteria and objective measures. However, patients suspected to have CRS based on a positive history but negative endoscopies remain a diagnostic challenge. We investigated the utility of point of care computed tomography (POC-CT) in resolving this issue. Methods The study group consisted of a simple random sample of 100 patients presenting with active CRS symptoms and negative endoscopies who underwent POC-CT at initial presentation. Presenting symptoms and comorbidities were correlated with CT scan results (positive/negative) using univariate and multivariate logistic regression models. Results POC-CT was considered positive in 49% of patients. Univariate analysis revealed that patients complaining nasal obstruction were significantly more likely to have a positive scan (odds ratio [OR], 2.74; p = 0.047), while those with postnasal drip (OR, 0.44; p = 0.047) or cough (OR, 0.17; p = 0.03) were less likely to have positive scan results. In the multivariate model, these trends persisted without reaching statistical significance. Under univariate analysis, patients who were prescribed antibiotics, oral steroids, or nasal steroids at this initial visit were more likely to have had a positive CT. These trends also persisted in the multivariate model, with significance observed for the association between antibiotic prescription and a positive scan (p = 0.001). Conclusion Less than 50% of patients with active CRS symptoms had radiographic manifestations of sinus disease. Other etiologies must be considered higher in the differential for those presenting primarily with complaints referable to the throat. POC-CT averted unnecessary antibiotics in these patients. © 2011 ARS-AAOA, LLC.
Deformable Image Registration Based on Gabor Wavelet and SVM

This paper presents a novel deformable registration method based on Gabor Wavelet and SVM. The method introduces Gabor Wavelet and SVM theory to match brain images. Firstly, the coefficients of wavelet are extracted and optimal search radiuses are reached. With the guidance of the SVM, the deformable registration overcomes the shortages of rigid registration, owning the generalization and presenting an excellent robustness.
Statistical analysis of network traffic for adaptive faults detection

This paper addresses the problem of normal operation baselining for automatic detection of network anomalies. A model of network traffic is presented in which studied variables are viewed as sampled from a finite mixture model. Based on the stochastic approximation of the maximum likelihood function, we propose baselining network normal operation, using the asymptotic distribution of the difference between successive estimates of model parameters. The baseline random variable is shown to be stationary, with mean zero under normal operation. Anomalous events are shown to induce an abrupt jump in the mean. Detection is formulated as an online change point problem, where the task is to process the baseline random variable realizations, sequentially, and raise alarms as soon as anomalies occur. An analytical expression of false alarm rate allows us to choose the design threshold, automatically. Extensive experimental results on a real network showed that our monitoring agent is able to detect unusual changes in the characteristics of network traffic, adapt to diurnal traffic patterns, while maintaining a low alarm rate. Despite large fluctuations in network traffic, this work proves that tailoring traffic modeling to specific goals can be efficiently achieved.
A phenomenological model of plasma FFA, glucose, and insulin concentrations during rest and exercise

A phenomenological mathematical model for predicting FFA-glucose-insulin dynamics during rest and exercise was developed. The dynamical effects of insulin on glucose and FFA were divided into three parts: (i) insulin-mediated glucose uptake by tissues, (ii) insulin-mediated suppression of endogenous glucose production, and (iii) anti-lipolytic effects of insulin. Labeled and unlabeled intravenous glucose tolerance test data were used to estimate the parameters of the glucose model, which facilitated separation of insulin action on glucose utilization and production. The model successfully captured the FFA-glucose interactions at the systemic level. The model also successfully predicted mild-to-moderate exercise effects on FFA, glucose, and insulin dynamics. Model predictions of FFA, glucose and insulin profiles were validated with existing literature data. This composite model provides a new test platform for the development of closed-loop glucose control algorithms.
Virtual workspaces: Achieving quality of service and quality of life in the Grid

By defining standardized protocols for discovering, accessing, monitoring, and managing remote computers, storage systems, networks, and other resources, Grid technologies make it possible—in principle—to allocate resources to applications dynamically, in an on-demand fashion [1]. However, while Grids offer users access to many diverse and powerful resources, they do little to ensure that once a resource is accessed, it fulfills user expectations for
Optimal motion planning for multiple robots having independent goals

This work makes two contributions to geometric motion planning for multiple robots: i) motion plans can be determined that simultaneously optimize an independent performance criterion for each robot; ii) a general spectrum is defined between decoupled and centralized planning. By considering independent performance criteria, we introduce a form of optimality that is consistent with concepts from multi-objective optimization and game theory research. Previous multiple-robot motion planning approaches that consider optimality combine individual criteria into a single criterion. As a result, these methods can fail to find many potentially useful motion plans. We present implemented, multi-robot motion planning algorithms that are derived from the principle of optimality, for three problem classes along the spectrum between centralized and decoupled planning: i) coordination along fixed, independent paths; ii) coordination along independent roadmaps; iii) general, unconstrained motion planning. Several computed examples are presented for all three problem classes that illustrate the concepts and algorithms.
Indentured Servants: New Light on Some of America's “First” Families

Among the commodities which could profitably be shipped to the English plantations in America, a parcel of human beings was not the least remunerative. The colonists demanded labor, and were willing to pay for it. For a hundred years after the founding of Virginia this demand was met by the transportation and sale of white indentured servants recruited in Great Britain and Ireland, and so great was the volume of this business that the servants made up about three quarters of all immigrants coming to the colonies south of New York. During the eighteenth century their exclusive sway was gradually disputed by German redemptioners and Negro slaves, yet indentured servants continued to play a vital part in colonial life and to form an important element in colonial trade. The progenitor of many a proud American family found himself landed upon these shores not so much on account of his desire to seek freedom as because his person could be advantageously exchanged for a quantity of tobacco, lumber, or sassafras root.
A New, Necessary and Sufficient Vertex Solution for Robust Stability Check of Unstructured Convex Combination Matrix Families

This paper revisits the problem of checking the robust stability of matrix families generated by ‘Unstructured Convex Combinations’ of user supplied or externally supplied Vertex Matrices. A previous solution given by the author for this problem involved complete dependence on the quantitative (eigenvalue information) of a set of special matrices labeled the Kronecker Nonsingularity (KN) matrices. In this solution, the ‘convexity’ property is not explicit and transparent, to the extent that, unfortunately, the accuracy of the solution itself is being questioned and not embraced by the peer community. To erase this unforunate and unwarranted image of this author (in this specific problem) in the minds of the peer community, in this paper, the author treads a new path to find a solution that brings out the convexity property in an explicit and understandable way. In the new solution presented in this paper, we combine the qualitative (sign) as well as quantitative (magnitude) information of these KN matrices and present a vertex solution in which the convexity property of the solution is transparent making it more elegant and accepatble to the peer community, than the previous solution. The new solution clearly underscores the importance of using the sign structure of a matrix in assessing the stability of a matrix. This new solution is made possible by the new insight provided by the qualitative (sign) stability/instability derived from ecological principles. Examples are given which clearly demonstrate effectiveness of the new, convexity based algorithm. It is hoped that this new solution will be embraced by the peer community.Copyright © 2015 by ASME
Armand Hammer's unique diplomacy

(1986). Armand Hammer's unique diplomacy. Bulletin of the Atomic Scientists: Vol. 42, Chernobyl: The Emerging Story, pp. 50-52.
Interhospital Facility Transfers in the United States: A Nationwide Outcomes Study.

OBJECTIVES Patient transfers between hospitals are becoming more common in the United States. Disease-specific studies have reported varying outcomes associated with transfer status. However, even as national quality improvement efforts and regulations are being actively adopted, forcing hospitals to become financially accountable for the quality of care provided, surprisingly little is known about transfer patients or their outcomes at a population level. This population-wide study provides timely analyses of the characteristics of this particularly vulnerable and sizable inpatient population. We identified and compared characteristics and outcomes of transfer and nontransfer patients. METHODS With the use of the 2009 Nationwide Inpatient Sample, a nationally representative sample of U.S. hospitalizations, we examined patient characteristics, in-hospital adverse events, and discharge disposition for transfer versus nontransfer patients in this observational study. RESULTS We identified 1,397,712 transfer patients and 31,692,211 nontransfer patients. Age, sex, race, and payer were significantly associated with odds of transfer (P < 0.05). Transfer patients had higher risk-adjusted inpatient mortality (4.6 versus 2.1, P < 0.01), longer length of stay (13.3 versus 4.5, P < 0.01), and fewer routine disposition discharges (53.6 versus 68.7, P < 0.01). In-hospital adverse events were significantly higher in transfer patients compared with nontransfer patients (P < 0.05). CONCLUSIONS Our results suggest that transfer patients have inferior outcomes compared with nontransfer patients. Although they are clinically complex patients and assessing accountability as between the transferring and receiving hospitals is methodologically difficult, transfer patients must nonetheless be included in quality benchmark data to assess the potential impact this population has on hospital outcome profiles. With hospital accountability and value-based payments constituting an integral part of health care reform, documenting the quality of care delivered to transfer patients is essential before accurate quality assessment improvement efforts can begin in this patient population.
URBAN NEIGHBORHOODS, BLACK RESIDENTS, AND HOMICIDE RISK

Since the mid-1960s, homicide as a cause of death has been growing in importance in American society. Most analyses of homicide patterns focus primarily on the interaction between the victim and of...
Uncertainty evaluation for determination of sorbic acid in juice by HPLC

Objective: The uncertainty evaluation of determination of sorbic acid in juice by HPLC.Methods:Regressive equation is applied for uncertainty evaluation is introduced in detail.Results:The relative uncertainty of determination of sorbic acid in juice by HPLC is 6.2%.Extend uncertainty is 0.026 g/kg.Conclusion:The idea can be used for reference in uncertainty evaluation of HPLC determination.
Rethinking Protection of Those Displaced by Humanitarian Crises

In June 2015, the UN High Commissioner for Refugees announced a landmark event in the history of his organization. UNHCR estimated that there were more refugees and displaced persons than it had counted since its establishment in 1950--almost 60 million who fled conflict and persecution. While certainly large in its own right, the number actually underestimates displacement in today's world. Many millions more are displaced each year and cumulatively from a much broader range of life-threatening humanitarian crises than captured by UNHCR's figures. An average of 26.4 million were displaced annually by acute natural hazards since 2008 and an unknown but sizeable number from gang and cartel violence, electoral and communal violence, nuclear and industrial accidents, and a range of other human made disasters. This paper argues for new legal, institutional and operational frameworks to more effectively address the situation of the totality of displaced persons.
What Is DevOps

Software development is still a young industry. As an industry, it’s rapidly evolving and trying to become better. And growth is really necessary. The software development industry doesn’t have a very good reputation when it comes to producing software on time and on budget.
Preliminary Study of Oral Cancer in Saudi Arabia

La lesion la plus frequente a ete l'epithelioma malpighien (74,27%) avec la frequence la plus elevee au niveau de la langue. Les hommes sont plus souvent atteints que les femmes
Effects of climate and water balance across grasslands of varying C3 and C4 grass cover

Climate change in grassland ecosystems may lead to divergent shifts in the abundance and distribution of C3 and C4 grasses. Many studies relate mean climate conditions over relatively long time periods to plant cover, but there is still much uncertainty about how the balance of C3 and C4 species will be affected by climate at a finer temporal scale than season (individual events to months). We monitored cover at five grassland sites with co-dominant C3 and C4 grass species or only dominant C3 grass species for 6 yr in national parks across the Colorado Plateau region to assess the influence of specific months of climate and water balance on changes in grass cover. C4 grass cover increased and decreased to a larger degree than C3 grass cover with extremely dry and wet consecutive years, but this response varied by ecological site. Climate and water balance explained 10–49% of the inter-annual variability of cover of C3 and C4 grasses at all sites. High precipitation in the spring and in previous year monsoon storms influenced changes in cover of C4 grasses, with measures of water balance in the same months explaining additional variability. C3 grasses in grasslands where they were dominant were influenced primarily by longer periods of climate, while C3 grasses in grasslands where they were co-dominant with C4 grasses were influenced little by climate anomalies at either short or long periods of time. Our results suggest that future changes in spring and summer climate and water balance are likely to affect cover of both C3 and C4 grasses, but cover of C4 grasses may be affected more strongly, and the degree of change will depend on soils and topography where they are growing and the timing of the growing season.
Numerical study of particle mixing in a lab-scale screw mixer using the discrete element method

Abstract This study employs the discrete element method (DEM) to simulate particulate flow and investigate mixing performance of a lab-scale double screw mixer. The simulation employs polydispersed biomass and glass bead particles based on experiments conducted in previous studies. Visual examination of particle distribution and statistical analysis of particle residence times of experimental data served as model validation. Statistical analysis indicates a maximum 9.8% difference between the experimental and simulated biomass particle mean residence time, and visual observations suggest the simulation captures the particle mixing trends observed in the experiments. Results indicate that the particle mean mixing time, non-dimensionalized by ideal flow time in the plug flow reactor, varies between 1.008 and 1.172, and it approaches 1 with increasing biomass feed rate. The mixing index profile in the axial direction shows a mixing-demixing-mixing oscillation pattern. Increasing screw pitch length is detrimental to mixing performance; decreasing the solid particle feed rate reduces the mixing degree; and increasing the biomass to glass bead size ratio decreases mixing performance. A comparison of a binary, single-sized biomass and glass particles mixture to a multicomponent mixture indicates that the binary system has similar mixing pattern as a multicomponent system. These findings demonstrate that DEM is a valuable tool for the design and simulation of double screw mixing systems.
Characterization of field-evolved resistance to Bacillus thuringiensis-derived Cry1F δ-endotoxin in Spodoptera frugiperda populations from Argentina.

BACKGROUND Transgenic maize (Zea mays L.) event TC1507 (Herculex® I insect protection), expressing Cry1F δ-endotoxin derived from Bacillus thuringiensis var. aizawai, was commercialized in 2003 in the Americas. Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) susceptibility to Cry1F was monitored annually across several regions in Argentina using diagnostic concentration bioassays. Reduced performance of TC1507 maize against S. frugiperda was reported in 2013. A resistant population was established in the laboratory and the dominance of Cry1F resistance was characterized. RESULTS: During 2012–2015, high-survivorship of several populations was observed in the resistance monitoring program. Reciprocal crosses of a Cry1F-resistant population with a Cry1F-susceptible population were evaluated to calculate effective dominance (DML) based on mortality levels observed at 100 µg/ml Cry1F. Two additional dominance levels (DLC and DEC) were calculated using lethal (LC50) or effective concentration (EC50) derived from concentration-response bioassays. Estimates indicated that Cry1F resistance in S. frugiperda in Argentina was either highly-recessive (DML=0.005) or incompletely recessive (DLC < 0.26 and DEC<0.19). CONCLUSION This study is the first documented confirmation and characterization of S. frugiperda Cry1F field-evolved resistance in Argentina. The resistance to Cry1F in S. frugiperda populations collected in Argentina, is autosomal and incompletely recessive similar to the resistance reported in Brazil.
Association of Psychiatric Illness or Psychotropic Medication Usage with Calcaneus Fracture.

Background There is a noticeable lack of studies examining the connection between psychiatric illness and orthopaedic injury. The goal of this study is to determine if a relationship exists between calcaneus fracture and psychiatric illness or use of psychotropic medication. Methods A retrospective review was undertaken of calcaneus fracture patients at our institution from January 2011 through January 2014, and those with a diagnosis of psychiatric illness or history of psychotropic medication usage were identified. Medication records were analyzed along with medical histories taken during the initial encounter. If the patient was admitted, hospital notes for the hospitalization were reviewed to determine if any information was missed during the initial encounter. The date of injury, age, sex, insurance status at the time of initial encounter, psychiatric diagnoses or psychotropic medication use, and mechanism of injury were recorded. Any specific psychiatric diagnoses were collected from the patient charts, as was the presence of any specific prescribed psychotropic medications. After completion of the data collection, an attending psychiatrist verified the recorded data to ensure an accurate psychiatric assessment. Results A total of 85 calcaneus fractures met the inclusion criteria. In the population, there were 71 males and 14 females. The average age of the patients was 41.74 years, with 24% of patients having a diagnosis of psychiatric illness at the time of injury. The relative risk of a psychiatric illness in males compared to females was 0.31 (p = 0.009) while the relative risk of using psychotropic medication in males compared to females was 0.17 (p = 0.0007). Males were less likely to undergo operative intervention than females (p = 0.0001). The average age of a patient who either had a diagnosis or took medication for a psychiatric illness was 48.4 years, as compared to 39.7 years in those who did not (p = 0.014). Conclusion Males were less likely to have a psychiatric illness or be currently treated with psychotropic medications. A dedicated review of psychiatric history and prior medication may be useful during preoperative, perioperative, and postoperative treatment planning. Level of Clinical Evidence: 4.
Antenatal and Neonatal Antecedents of Executive Dysfunctions in Extremely Preterm Children

To find out why children born extremely preterm are at heightened risk of executive dysfunctions, the authors assessed 716 children who were 10 years old born extremely preterm whose IQ was ≥ 70. A working memory dysfunction (n = 169), an inhibition dysfunction (n = 360), a switching dysfunction (355), and all 3 (executive dysfunction; n = 107) were defined on the basis of Z-scores ≤ -1 on the Differential Ability Scales-II Working Memory composite, and/or on the NEPSY-II Inhibition-Inhibition and Inhibition-Switching subtests. All risk profiles include an indicator of socioeconomic disadvantage. The risk profile of each of the 3 individual dysfunctions includes an indicator of the newborn's immaturity, and the risk profiles of the inhibition dysfunction and switching dysfunction also include an indicator of inflammation. Only the switching dysfunction was associated with fetal growth restriction. The risk factors for executive dysfunction can be subsumed under the 4 themes of socioeconomic disadvantage, immaturity/vulnerability, inflammation, and fetal growth restriction.
Modeling the Impact of Alcohol on Cortical Development in a Dish: Strategies From Mapping Neural Stem Cell Fate

During the second trimester period, neuroepithelial stem cells give birth to millions of new neuroblasts, which migrate away from their germinal zones to populate the developing brain and terminally differentiate into neurons. During this period, large numbers of cells are also eliminated by programmed cell death. Therefore, the second trimester constitutes an important critical period for neuronal proliferation, migration, differentiation and apoptosis. Substantial evidence indicates that teratogens like ethanol can interfere with neuronal maturation. However, there is a paucity of good model systems to study early, second trimester events. In vivo models are inherently interpretatively complex because cell proliferation, migration, differentiation, and death mechanisms occur concurrently in regions like the cerebral cortex. This temporal overlap of multiple developmental critical periods makes it difficult to evaluate the relative vulnerability of any individual critical period. Our laboratory has elected to utilize fetal rodent cerebral cortical-derived neurosphere cultures as an experimental model of the second-trimester ventricular neuroepithelium. This model has enabled us to use flow cytometric approaches to identify neuroepithelial stem cell and progenitor sub-populations and to show that ethanol accelerates the maturation of neural stem cells. We have also developed a simplified mitogen-withdrawal/matrix-adhesion paradigm to model the exit of neuroepithelial cells from the ventricular zone towards the subventricular zone and cortical plate, and their maturation into multipolar neurons. We can treat neurosphere cultures with ethanol to mimic exposure during the period of neuroepithelial proliferation and by using the step-wise maturation model, ask questions about the impact of prior ethanol exposure on the subsequent maturation of neurons as they migrate and undergo terminal differentiation. The combination of neurosphere culture and stepwise maturation models will enable us to dissect out the contributions of specific developmental critical periods to the overall teratology of a drug of abuse like ethanol.
Effect of Mandible and Maxilla Osteotomies on Velar, Oropharyngeal, and Hypopharyngeal Diameter

Purpose There is a lack of anatomic comparisons between maxillomandibular advancement (MMA) and other bony surgical treatments of obstructive sleep apnea (OSA). Surgical procedures were simulated in cadavers to evaluate their ability to expand the posterior airway space (PAS). Materials and Methods The following bony advancement surgeries were performed on each of 9 cadavers: genioglossal advancement (GGA); genioplasty with advancement of the genioglossus, geniohyoid, and anterior digastric muscles (GPA); bilateral sagittal split osteotomy; Le Fort I maxillary advancement; Le Fort I maxillary anterior impaction osteotomy (LFAI); MMA; MMA plus GPA; and MMA plus LFAI. Bony advancements were performed at increasing distances and change in PAS anteroposterior (AP) diameter was measured at the levels of the velum, oropharynx, and hypopharynx. Results Change in PAS varied in a linear fashion with advancement surgical maneuvers. GPA led to a greater increase in AP distance at the levels of the oropharynx and hypopharynx compared with GGA. LFAI showed a greater increase in AP distance at the velum compared with MMA. All maxillary movements showed greater AP expansion in the PAS at the velum compared with mandibular advancements. Conclusions Static AP expansion of the PAS at the levels of the velum, oropharynx, and hypopharynx occurs in a roughly linear and predictable pattern with different bony surgical procedures used in OSA surgery. MMA alone and MMA plus GPA had the overall greatest effect at all airway levels. GPA had a greater effect on expansion of the oropharynx and hypopharynx compared with GGA.
Practice Makes Perfect: Towards Learned Path Planning for Robotic Musicians using Deep Reinforcement Learning

When a pianist effortlessly glides across the keyboard during an improvised solo, the musician is executing a series of movements informed by years of practice ingrained with musical knowledge. This paper proposes an analogous approach that enables Robotic Musicians to learn about its degrees of freedom and physical constraints through "practice" in the form of Deep Reinforcement Learning. We use a Deep Q Network (DQN) to train a virtual agent representing a real 4-armed robotic musician, to motion-plan the optimal sequence of movements given a musical sequence through a learned strategy instead of a search strategy. Early results from our proof-of-concept system demonstrate that DRL can achieve optimal control of a musical agent, learning a form of bi-manual coordination in the process.
Risk factors for readmission within thirty days following revision total hip arthroplasty.

Abstract Background The number of total hip arthroplasties (THA) being performed has been steadily increasing for decades. With increased primary THA surgical volume, revision THA numbers are also increasing at a steady pace. With the aging, increasingly comorbid patient populations and newly imposed financial penalties for hospitals with high readmission rates, refining understanding of factors influencing readmission following THA is a research priority. We hypothesize that numerous preoperative medical comorbidities and postoperative medical complications will emerge as significant positive risk factors for 30-day readmission. Methods ACS-NSQIP database identified patients who underwent revision THA from 2005 to 2015. The primary outcome assessed was hospital readmission within 30 days. Patient demographics, preoperative comorbidities, laboratory studies, operative characteristics, and postsurgical complications were compared between readmitted and non-readmitted patients. Logistic regression identified significant independent risk factors for 30-day readmission among these variables. Results 10,032 patients underwent revision THA in the ACS-NSQIP from 2005 to 2015; 855 (8.5%) were readmitted within 30-days. Increasing age, the presence of preoperative comorbidities, high ASA class, and increased operative time were significant positively associated independent risk factors for 30-day readmission. Several postoperative medical and surgical complications such as myocardial infarction, stroke, pneumonia, and sepsis demonstrated significant positive associations with readmission. Conclusion Identifying and understanding risk factors associated with readmission allows for the implementation of evidence-based interventions aimed at minimizing risk and reducing 30-day readmission rates following revision THA.
Post-transplant Psychosocial and Mental Health Care of Hematopoietic Cell Transplant Recipients

Receiving the diagnosis of a hematopoietic malignancy is a terrifying experience, often leading to a hematopoietic stem cell transplant (HCT) as a potentially life-saving intervention. Undergoing an HCT is an extensive, multistep process involving chemotherapy, prolonged hospitalization, and invasive medical procedures. Patients endure significant physical effects that have the potential to become chronic. Given this, all healthcare providers understand that some form or variation of psychosocial distress is inevitable. This chapter will specifically focus on the spectrum of psychiatric sequelae in the post-HCT period, including depression, anxiety, posttraumatic stress disorder, and cognitive disorders. Additionally, a review of the most common somatic symptoms, fatigue and insomnia, in the post-HCT period are also highlighted given their direct impact on quality of life. Finally, we will review the unmet mental health needs identified in the literature, evidence-based guidelines for distress management, and approaches to psychotropic medication management.