cssi/SciSciGPT-SciSciNet huggingface dataset:
The Epidemiology and Diagnosis of Hypoactive Sexual Desire Disorder and Causes of HSDD: Situational, Depression, Drugs, Chronic Illnesses, and Hormonal Depletion

Hypoactive sexual desire disorder (HSDD) is defined as persistent deficient sexual fantasies and desire for sexual activity that causes marked distress or interpersonal difficulty and is not better accounted for by another psychiatric disorder or substance, medication, or medical condition. HSDD affects 10 % of women ages 18 and older. HSDD is associated with lower health-related quality of life, lower general happiness and relationship satisfaction, and low self-esteem. HSDD is underdetected; important areas for diagnostic evaluation include screening for depression, medications, relationship satisfaction, and androgen status. The decreased sexual desire screener is a tool for detecting and diagnosing HSDD, validated for use in primary care.
Children's knowledge of eating: An integrative review of the literature

Behaviors associated with eating are often cited as one of many factors contributing to the development of childhood obesity. Behavior is thought to be guided, in part, by personal beliefs and tacit knowledge, which arise from the interpretation of sensory-motor experiences. Tacit knowledge, however, differs from declarative knowledge or the acquisition of factual information attained during formal education. Yet, there are no known publications that review children's and adolescent's tacit and declarative knowledge of eating. The purpose of this integrative review was to examine the evidence regarding children's and adolescents' knowledge of eating. Literature searches were conducted in CINAHL, PsycINFO, Web of Science, and Google Scholar. Selected publications included in the integrative review were empirical studies written in English that described children's and adolescent's knowledge of eating. A total of 548 publications resulted from the searches. Thirty met the inclusion criteria. Preschool-age children understood concepts related to edibleness, nutrition, and digestion as a result of their experiences with food and eating. School-age children and adolescents correctly identified not only facts about food, nutrition, and health, but also factors that influenced their decisions about eating. School-age children and adolescents also expressed concern about their diet, barriers to being healthy, and their appearance. Evidence presented in this integrative review revealed that children, including those of preschool-age, know a great deal about eating. Moreover, the evidence suggests that beliefs and tacit knowledge are more influential in directing eating behaviors than declarative knowledge or knowing facts about food, nutrition, the body, or health. Understanding what children believe and tacitly know about eating will be useful in tailoring interventions to prevent the development of childhood obesity.
Polarization-based control of spin-orbit hybrid modes of light in biphoton interference

We report the experimental generation of a class of spin-orbit hybrid modes via an asymmetric Mach-Zehnder interferometer, whose intensity and polarization distributions may be tuned by manipulating the polarization state of the interferometer input beam. In the case of an equivalent biphoton input, we predict that this device will exhibit biphoton (Hong-Ou-Mandel) interference in conjunction with these mode transformations.
Evaluation of a Novel Single-Use Flexible Ureteroscope.

Abstract Introduction: A novel single-use flexible ureteroscope promises the optical characteristics and maneuverability of a reusable fourth-generation flexible ureteroscope. In this study, the LithoVue Single-Use Digital flexible ureteroscope was directly compared with contemporary reusable flexible ureteroscopes, with regard to optics, deflection, and irrigation flow. Methods: Three flexible ureteroscopes such as the LithoVue (Single Use; Boston Scientific), Flex-Xc (Karl Storz, Germany), and Cobra (Richard Wolf, Germany) were assessed in vitro for image resolution, distortion, color representation, grayscale imaging, field of view, and depth of field. Ureteroscope deflection was tested with an empty channel followed by placement of a 200 μm laser fiber and a 1.9F wire basket, a 2.0F nanoelectric pulse lithotripsy (NPL) probe, and a 2.4F NPL probe. Ureteroscope irrigation flow was measured using normal saline at 100 cm, with an empty channel followed by a 200 μm laser fiber, a 1.9F wire basket and a 2....
MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance

microRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of gene expression and play critical roles in human malignancies. Next-generation sequencing analysis of the MCF-7 breast cancer cell line overexpressing miR-335-5p and miR-335-3p demonstrated that the miRNA duplex repressed genes involved in the ERα signaling pathway, and enhanced resistance of MCF-7 cells to the growth inhibitory effects of tamoxifen. These data suggest that despite its conventional role in tumor suppression, the miR-335 transcript can also play an oncogenic role in promoting agonistic estrogen signaling in a cancerous setting.
CONCURRENCY IN A REAL-TIME MULTI-USER SIMULATION

Current methods of Real-Time simulation involving multiple users are non-scalable, difficult to develop, difficult to maintain, and expensive. Concurrent computer usage is exploding. The ability to edit documents, 3D models, and interact with multi-user simulations by users who are remote from one another is an emerging technology. Current techniques do not scale well and require a large infrastructure investment. This research addressed issues in which existing infrastructure of the clients’ PCs can be leveraged to the computational demands of distributed interaction. In this research, I investigated the feasibility, of a thin server – peer client architecture for real-time multi-user simulation. This project involved a number of issues in simulating a shared environment on multiple computers, with multiple users in real-time. These issues included: latency, synchronization of state, events, clients coming into or leaving the simulation, security, and privacy. Solutions for data conflict resolution that were investigated included distributed state verification (peer voting) and master-client (one or more clients are designated as arbiters of truth).
Proximity effect correction in electron-beam lithography II

Many techniques have been proposed for the reduction or correction of the proximity effect. These include the use of an appropriate beam energy, multilayer resists, dose correction, and correction exposures. Here, special emphasis is placed on dose correction schemes. In particular, the relationship between these and a typical correction exposure scheme (GHOST) is described. The popular 'self consistent' schemes are in widespread use. However, alternative dose correction schemes with attractive attributes exist, although they are not as well known. Two of these are described. One treats electron lithography as a form of incoherent imaging, characterized by a modulation transfer function (MTF). The method consists of transforming the pattern data to account for this MTF, thus eliminating the proximity effect. This scheme is both computationally efficient and accurate. The other scheme is an extension of GHOST in which dose corrections are computed by simulating the effects of a correction exposure: it too is fast and accurate.
The will and the way of inclusive education in Macao

Purpose The Macao SAR has instituted a policy-driven change that calls for schools to accept pupils with special education needs. However, making schools diverse and inclusive requires the consideration of multiple dimensions, such as the acceptance of all parties concerned, tangible and intangible support structures and cultures, and adequate resources. The purpose of this paper is to focus on understanding teachers’ attitudes and perceived challenges towards the implementation of inclusion in a context distinguished by a prevalence of the private sector of education. Design/methodology/approach This qualitative study used grounded theory procedures through document analysis and in-depth interviews with teachers to analyse the attitudes and perceptions regarding inclusive education in the context of policy revision. Findings Data analysis revealed five themes related to teachers’ attitudes and perceptions: understanding inclusion; outcomes of inclusion; attitudes towards inclusion; preparedness to work in inclusive settings; and challenges and barriers. It is concluded that teachers show mixed positive and negative attitudes towards inclusion. Although the teachers acknowledge the significance of the reform, few of them feel prepared for and comfortable with teaching children with SEN. A lack of resources and support, and a disintegrated approach to inclusion seems to hinder the enactment of inclusive practices. Societal preconceptions against the full inclusion of children with disabilities in regular settings were reported by the participants. Originality/value This paper suggests ways to support teachers and expand inclusion practices in Macao.
Abstract WMP106: Reversal of Tonic Inhibition Contributes to Recovery of Synaptic Function After Transient Focal Cerebral Ischemia

Introduction: Ischemic stroke is the fourth leading cause of death in the United States and is increasingly being recognized as a disease that occurs in people of all ages, not just the elderly. St...
The Spherical Model

The larger of the two stars (disregarding luminosity and mass) is assigned the index 1, the smaller 2. The ratio of the radii is k = r2/r1 < 1. The true dimension of the system does not affect the light variation, and the radius (or semiaxis major) of the orbit can be taken as the unit of length. The total light intensity of the pair (in rectified form, if necessary) is the unit of brightness: L 1 + L 2 = 1. Let the symbol L(t) for the light curve now be more specifically defined as the fractional light loss at any instant, compared with the unit of total light. L(t) is directly measured in intensities, or can be converted from magnitudes: $$\log \left( {1 - L} \right) = 0.4\left( {{m_0} - {m_0}} \right)$$ , where m0 is the constant (or rectified) magnitude outside of eclipse.
Convergence of Gradient EM on Multi-component Mixture of Gaussians

In this paper, we study convergence properties of the gradient variant of Expectation-Maximization algorithm~\cite{lange1995gradient} for Gaussian Mixture Models for arbitrary number of clusters and mixing coefficients. We derive the convergence rate depending on the mixing coefficients, minimum and maximum pairwise distances between the true centers, dimensionality and number of components; and obtain a near-optimal local contraction radius. While there have been some recent notable works that derive local convergence rates for EM in the two symmetric mixture of Gaussians, in the more general case, the derivations need structurally different and non-trivial arguments. We use recent tools from learning theory and empirical processes to achieve our theoretical results.
Oxidation-Reduction Properties of Escherichia coli Thioredoxin Reductase Altered at Each Active Site Cysteine Residue*

Thioredoxin is a small oxidation-reduction (redox) mediator protein. Its reduction by NADPH is catalyzed by the flavoenzyme thioredoxin reductase. Site-directed mutagenesis has provided forms of the reductase in which Cys135 and Cys138 have each been changed to a serine residue (Prongay, A. J., Engelke, D. R., and Williams, C. H., Jr. (1989) J. Biol. Chem. 264, 2656-2664). Cys135 and Cys138 form the redox-active disulfide in the oxidized enzyme. The redox properties of the two altered forms of Escherichia coli thioredoxin reductase have been determined from pH 6.0 to 9.0. Photoreduction of TRR(Ser135,Cys138) produces the blue, neutral semiquinone species, which disproportionates (Kf = 0.73) to an apparent maximum of 29% of the total enzyme as the semiquinone. In contrast, the semiquinone formed on TRR(Cys135,Ser138) during a photoreductive titration does not disproportionate and 70% of the enzyme is stabilized as the semiquinione. Reductive titrations have demonstrated that 1 mol of sodium dithionite (2 electrons)/mol of FAD is required to fully reduce TRR(Ser135,Cys138) whereas 2 mol of dithionite/mol of FAD are required to fully reduce TRR(Cys135,Ser138). The oxidation-reduction midpoint potentials for the 1-electron and 2-electron reductions of TRR(Ser135,Cys138) have been determined by NADH/NAD+ titrations in the presence of a mediator, benzyl viologen. The midpoint potential for the 2-electron reduction of TRR(Ser135,Cys138) is -280 mV, at pH 7.0 and 20 degrees C. Thus, the redox potential is similar to that of the FAD/FADH2 couple in the dithiol form of wild type enzyme, -270 mV (corrected to 20 degrees C) (O'Donnell, M. E., and Williams, C. H., Jr. (1983) J. Biol. Chem. 258, 13795-13805). The delta Em/delta pH is -57.1 mV, which corresponds to a proton stoichiometry of 2 H+/2 e-.A maximum of 19% of the enzyme forms a stable semiquinone species during the titration, and the potentials for the oxidized enzyme/semiquinone couple, E2, and the semiquinone/reduced enzyme couple, E1, are -306 and -256 mV, respectively, at pH 7.0 and 20 degrees C. These studies provide evidence that the residue at position 138 exerts a greater effect on the FAD than does the residue at position 135.
Role and impact of student pharmacists and a pharmacist on an international interprofessional medical brigade.

Abstract Background and purpose Colleges of pharmacy will be seeking new opportunities to provide student pharmacists with interprofessional and global experiences. The objectives of this paper are to describe an international experience to expand interprofessional and global pharmacy education and to evaluate the roles and impact of fourth-year pharmacy students and a pharmacist integrated into an interprofessional team on a medical brigade to Guatemala. Educational activity and setting In August 2014, two fourth-year student pharmacists and one pharmacist/professor joined a group of 26 pre-medical students from Boston College (BC), six medical doctors and a nursing assistant as part of a one-week medical brigade to Quetzaltenango, Guatemala. An electronic survey was administered to all brigade members upon completion of travel. The survey assessed the most useful services provided by the pharmacist and pharmacy students on the brigade and changes in perspective towards the role of pharmacy on an interprofessional healthcare team. The survey also collected information describing satisfaction with communication, efficiency, professionalism and knowledge of the pharmacy staff. Findings and discussion Pharmacy staff was utilized for knowledge of drug products, therapeutic substitution, counseling and drug dosing/calculations. The brigade directly resulted in an increased likelihood for physicians and students to refer a question to a pharmacist. After this brigade, all non-pharmacy members viewed pharmacists as important members of the medical team and felt better prepared to work as part of a team. Summary The experience was effective in fostering interprofessional relationships amongst healthcare students and professionals.
Rare earth elements recovery using staged precipitation from a leachate generated from coarse coal refuse

Abstract Recovery of rare earth elements (REEs), especially heavy and critical REEs, from alternative resources such as coal refuse has recently become increasingly important. A natural leachate containing 6.14 ppm of REEs with a pH value of 2.70 was collected from a coal coarse refuse pile and utilized as a feedstock for REE recovery tests. The pH value of the natural leachate was gradually increased in a step-wise manner using a sodium hydroxide solution which produced several precipitates. A precipitate containing about 1.1% total REEs was obtained in the pH range of 4.85–6.11 while recovering >80% of the REEs contained in the original leachate. The leaching and staged precipitation process enriched both the critical and heavy REE fractions. The ratios of heavy-to-light (H/L) and critical-to-uncritical (C/UC) REEs in the precipitate were much higher than the coarse refuse material (H/L: 1.54 vs 0.21, C/UC: 1.51 vs 0.34). Additionally, the precipitate contained 18.4% Al, 1.7% Zn, 1.4% Cu, 1.1% Mn, 0.5% Ni and 0.2% Co. A solution chemistry study indicated that the hydroxide and hydroxysulphate precipitates of Al, Si and Cu produced in the pH range of 4.85–6.11 contributed to the fractionation of the REEs and other metal ions such as Zn, Mn and Co to the precipitate. The iron hydroxide precipitates formed at lower pH values did not contain a significant amount of REEs. An explanation may be the competitive adsorption between Al, which was present at higher solution concentrations, and REEs on the iron hydroxide and/or hydroxysulphate precipitate surfaces as proven by results of precipitation tests conducted on model solutions. A product containing 94% of a rare earth oxide mix was obtained by re-dissolution of the REE enriched precipitates followed by selective precipitation using oxalic acid. The overall results including an economic assessment indicate that leachate solutions generated naturally from coarse coal refuse may be a valuable source of critical and heavy REEs that can be effectively recovered and concentrated using staged precipitation.
How to Write an Effective Journal Article Review

The experience of reviewing manuscripts for scientific journals is an important one in professional development. Reviewing articles gives trainees familiarity with the peer review process in ways that facilitate their writing. For example, reviewing manuscripts can help students and early career psychologists understand what reviewers and editors look for in a peer-reviewed article and ways to critique and enhance a manuscript based on peer review. Experiences in review can facilitate early career faculty with early entry into and experience being a reviewer for a professional journal. The experience of journal reviews also gives students a broader connection to the field of science in areas of their primary professional interest. At the same time reviewing articles for scientific journals poses a number of difficult challenges (see Hyman, 1995; Drotar, 2000a, 2009a, 2009b, 2009c, 2009d, 2010, 2011; Lovejoy, Revenson, & France, 2011). The purpose of this chapter is to provide an introduction to the review process and give step by step guidance in conducting reviews for scientific journals. Interested readers might wish to read Lovejoy et al.’s (2011) primer for manuscript review, which contains annotated examples of reviews and an editor’s decision letter.
Studies on the nucleotide arrangement in deoxyribonucleic acids: XII. Apyrimidinic acid from calf-thymus deoxyribonucleic acid: Preparation and properties☆

Abstract A standard procedure for the preparation of apyrimidinic acid from calf-thymus DNA is described and the degradative reactions forming the basis of the method are considered in some detail. The product is considered as a mixture of polydeoxyribophosphates retaining the purines of the parent DNA in essentially unchanged proportions and possessing free deoxyribose residues at the positions originally occupied by pyrimidines. Some of the chemical and physical properties of apyrimidinic acid are also discussed.
Timelessness and freedom

One way that philosophers have attempted to defend free will against the threat of fatalism and against the threat from divine beliefs has been to endorse timelessness views (about propositions and God’s beliefs, respectively). In this paper, I argue that, in order to respond to general worries about fatalism and divine beliefs, timelessness views must appeal to the notion of dependence. Once they do this, however, their distinctive position as timelessness views becomes otiose, for the appeal to dependence, if it helps at all, would itself be sufficient to block worries about fatalism and divine beliefs. I conclude by discussing some implications for dialectical progress.
Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor

Although chemotherapy is a conventional cancer treatment, it may induce a protumorigenic microenvironment by triggering the release of proinflammatory mediators. In this study, we demonstrate that ovarian tumor cell debris generated by first-line platinum- and taxane-based chemotherapy accelerates tumor progression by stimulating a macrophage-derived “surge” of proinflammatory cytokines and bioactive lipids. Thus, targeting a single inflammatory mediator or pathway is unlikely to prevent therapy-induced tumor progression. Here, we show that combined pharmacological abrogation of the cyclooxygenase-2 (COX-2) and soluble epoxide hydrolase (sEH) pathways prevented the debris-induced surge of both cytokines and lipid mediators by macrophages. In animal models, the dual COX-2/sEH inhibitor PTUPB delayed the onset of debris-stimulated ovarian tumor growth and ascites leading to sustained survival over 120 days postinjection. Therefore, dual inhibition of COX-2/sEH may be an approach to suppress debris-stimulated ovarian tumor growth by preventing the therapy-induced surge of cytokines and lipid mediators.
Impact of smoking on outcomes following knee and shoulder arthroscopy

The purpose of this study is to evaluate any association between preoperative smoking and perioperative and early postoperative complications in patients following shoulder and knee arthroscopic surgery. This is a retrospective study using the prospectively collected National Surgery Quality Improvement Program database. All patients who underwent eight specific shoulder and knee arthroscopy procedures, identified by current procedural terminology codes, were included in this study and analyzed using univariate and multivariate analyses to determine the impact of preoperative smoking status on postoperative complications. These procedures were knee arthroscopy with meniscectomy (medial or lateral), knee arthroscopy with meniscectomy (medial and lateral), knee arthroscopy with chondroplasty, knee arthroscopy with anterior cruciate ligament reconstruction, shoulder arthroscopy with subacromial decompression, shoulder arthroscopy with debridement, subacromial arthroscopy with rotator cuff repair, and shoulder arthroscopy with distal clavicle excision. Thirty-day complications including cardiac, renal, wound, pulmonary, clotting, and mortality were assessed following knee and shoulder arthroscopy. A total of 134,822 cases were included in the study. Multivariate analysis found that smoking was an independent risk factor for complications in shoulder arthroscopy with subacromial decompression (odd’s ratio [OR] = 1.46; 95% confidence interval [CI] 1.030–2.075), shoulder arthroscopy with debridement (OR = 1.933; 95% CI 1.211–3.084), and knee arthroscopy with medial and lateral meniscectomy (OR = 1.97; 95% CI 1.407–2.757). Smoking was not an independent risk factor for complications in the other five procedures studied. Preoperative smoking was found to be an independent risk factor for complications for several arthroscopic procedures, though with variability between specific procedures.
Key Principles of Antiretroviral Pharmacology

Antiretroviral therapy has advanced significantly since zidovudine was first approved. Although 31 antiretrovirals have been approved by the FDA, only about half of those are commonly used. Newer, more tolerable agents have made human immunodeficiency virus into a chronic condition, which can be managed with medication. The most common antiretroviral regimens consist of 2 nucleoside reverse transcriptase inhibitors plus a third agent, often an integrase inhibitor because of better tolerability and fewer drug interactions than other regimens. Understanding the dosage forms, adverse effects, and drug interactions of antiretrovirals allow clinicians to choose the most appropriate regimen for their patient. New developments, such as branded generic regimens and long-acting intramuscular injections, may play a larger role in the future.
Use of reflective analysis to achieve exercise participation in a patient with severe cognitive impairment: a case report

ABSTRACTAs individuals decline cognitively physiotherapists’ attitudes become more negative. Evidence supports the use of experiential learning modules in a curriculum to improve student confidence...
Are Apparel Design and Merchandising Programs’ Curriculum Building Students’ Soft Skills? A Pilot Study Regarding the Presence of Communication and Leadership Skills

The purpose of this pilot study was to evaluate the soft skills education, specifically communication and leadership skills, in the higher education curriculum within undergraduate apparel design and merchandising programs. Student learning outcomes and/or course objectives in course syllabi from three southeastern universities in the United States were reviewed and analyzed to evaluate education opportunities or lack thereof for students to learn and develop soft skills within the courses in the curriculum. A majority of courses (59.5%) had at least one student learning outcome and/or course objective related to the soft skills of communication or leadership. The study revealed there is much improvement to be made regarding the presence of education of soft skills within apparel design and merchandising programs in undergraduate higher education.
Symmetry-based nonperturbative micromanipulation in a three-dimensional microfluidic device

A three-dimensional microfluidic device with embedded symmetries enables rich flow controls for complex manipulations of particles. These flow characteristics, especially a strain-free flow with uniform flow velocities, are protected by symmetries. This nonperturbative capability serves as a supplement to current perturbative micromanipulation approaches.
S19.1 Perspectives from north america

Background As in other regions, rates of gonorrhea in North America continue to rise, while Neisseria gonorrhoeae (Ng) antimicrobial susceptibility, and particularly macrolide susceptibility, has declined. These patterns have heightened concerns about emerging resistance to the only remaining recommended treatment regimen and the prospect of untreatable gonorrhea. Methods In this session, available data on Ng antimicrobial susceptibility trends in North America will be reviewed, with a focus on recent trends in cephalosporin, macrolide, and fluoroquinolone susceptibility. Public health responses, such as United States outbreak preparedness and response activities, will be explored. Results Although the percentage of Ng isolates with reduced cephalosporin susceptibility has declined in recent years in the United States and Canada, the percentage with reduced azithromycin susceptibility has increased in both countries. High-level azithromycin resistant strains have been identified in the United States, and an isolate with a high ceftriaxone minimum inhibitory concentration (1 µg/ml) was identified in Canada (2017). Data from Mexico are limited. In addition to robust surveillance in the United States and Canada, the United States has implemented efforts to enhance rapid detection and response to Ng resistance. Conclusions Robust surveillance and public health engagement are critical to address the growing threat of Ng resistance.
Dynamical grooming at work: from p+p to Pb+Pb.

We present a quantitative comparison between two grooming techniques: SoftDrop (SD) and Dynamical Grooming (DyG), in terms of the resilience of their associated observables to the underlying event, hadronization and pileup in proton-proton collisions at $\sqrt s\!=\! 13$ TeV. For that purpose, we study the groomed momentum fraction, $z_g$, in QCD jets along with boosted W tagging. In addition, we obtain the groomed momentum angle, $R_g$, within several jet quenching Monte-Carlo models in order to asses the sensitivity of SD and DyG observables to quark-gluon plasma (QGP) effects in heavy-ion collisions.
Evaluation of Pressure Filtration of Coal Refuse Slurry: Effects of pH, Filtration, and Air-Blow Times

Coal refuse slurry impoundments have potential environmental concerns associated with water contamination and impoundment stability. Pressure filtration can be used as an alternative method of hand...
How Mobile Homes Correlate With Per Capita Income

This study looks at the nature of the relationship between the number of state-regulated mobile homes and per capita income, so as to determine whether higher-income parts of Illinois have more mobile homes than would be predicted by the conventional wisdom. It does so by identifying a simple way to determine the nature of any relationship between mobile homes and per capita income, which the conventional wisdom assumes to be negative, if only at the county level in Illinois. The study, specifically, collects and analyzes mobile home data from Illinois and per capita income data from the U.S. Census. After combining these data, then using correlation coefficients, it finds a positive relationship: albeit with different intensities, based on whether the proxy for mobile homes in each county is the number of mobile home spaces or the number of mobile home parks in 2017.
A Novel Data Analytics Framework for the History Matching Problem for Reservoir Simulation in Up-Stream Petrochemical Industry

Matching the historical production of well and field with the simulated output is considered to be a technically challenging problem for the up-stream petrochemical industry. Even though a majority of industry solutions rely on the RMS analysis, it is widely accepted in the industry that RMS based solutions fail to provide any meaningful insight to the problem and fail to identify phenomenon like “Early Breakthrough” and “Late Breakthrough” and so on. In this paper, we discuss the “History Matching” problem and provide an overview of the data analytics based solution framework we developed in conjunction with a leading oil exploration company based in the middle-east. As opposed to the RMS based analysis, the core of our solution is based on the “Dynamic Time Warping” ‘(DTW), a proven technique for time series classification and temporal similarity matching exercises. We use the DTW distances scores and output from the DTW analysis to formulate the features that are provided as input to the machine learning algorithms for classification of simulation models.
IMMU-05. B7-H3-SPECIFIC CAR T CELLS HAVE POTENT ANTI-TUMOR ACTIVITY IN THE GL261 IMMUNE-COMPETENT MURINE BRAIN TUMOR MODEL

BACKGROUND We and others have identified B7-H3 (CD276) as a promising target for CAR-based immunotherapies for pediatric brain tumors. So far, B7-H3-CAR T cells have only been studied in xenograft models for brain tumors, which do not recapitulate the immunosuppressive tumor microenvironment (TME). To overcome this obstacle, we decided to adapt the immune-competent GL261 murine glioma model which mimics human disease and host immune barriers.
Cytomegalovirus nephritis in kidney transplant recipients: Epidemiology and outcomes of an uncommon diagnosis.

BACKGROUND Data on epidemiology and outcomes of cytomegalovirus (CMV) nephritis in kidney transplant patients are limited due to the rarity of this condition. METHODS A retrospective review of all kidney transplant recipients (KTR) (n = 6490) and biopsy-proven CMV nephritis between 1/1997 and 12/2020 was performed. RESULTS The prevalence of CMV nephritis was low: 13/6490 (0.2%). The diagnosis was made at a median of 7.0 months (range 2.6-15.6 months) after transplant. 6 of 13 (46%) patients were CMV (D+/R-). Median CMV DNA load at biopsy was 376,000, IU/mL (range 87,000-6,460,000 IU/mL). Main biopsy features were CMV glomerulitis (n = 7/13, 54%) followed by CMV tubulointerstitial nephritis (6/13; 46%). Mean eGFR at biopsy (22.7 ± 12 mL/min/1.73 m2 ) was significantly decreased compared to baseline eGFR (38.7 ± 18.5 mL/min/1.73 m2 , p = 0.02). The vast majority, 11 of 13 (85%), experienced graft failure including 5 of 13 (38%) death-censored. 5 of 13 (38%) patients were diagnosed with acute rejection: three had concurrent acute rejection, and two had rejection within 3 months of index biopsy, respectively. Patients with tubulointerstitial CMV nephritis were significantly more likely to have rejection at the time of biopsy (50% vs. 0%, p < 0.05) compared to those with glomerular CMV nephritis. There were no significant differences between these groups in terms of eGFR at all time points, death, graft failure, immunosuppression changes or rejection after biopsy. CONCLUSION CMV nephritis is rare but appears to be associated with poor patient/allograft outcomes. Early identification and timely treatment of CMV infection may prevent end-organ involvement and improve patient and allograft-related outcomes.
Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking

Substance P (SP) and its cognate neurokinin-1 receptor (NK1R) are involved in alcohol-related behaviors. We have previously reported that NK1R antagonism attenuates stress-induced reinstatement of alcohol seeking and suppresses escalated alcohol self-administration, but does not affect primary reinforcement or cue-induced reinstatement. Here, we administered an NK1R antagonist or vehicle prior to footshock-induced reinstatement of alcohol seeking, and mapped the resulting neuronal activation using Fos immunohistochemistry. As expected, vehicle treated animals exposed to footshock showed induction of Fos immunoreactivity in several regions of the brain stress circuitry, including the amygdala (AMG), nucleus accumbens (NAC), dorsal raphe nucleus (DR), prefrontal cortex (PFC), and bed nucleus of the stria terminalis (BNST). NK1R antagonism selectively suppressed the stress-induced increase in Fos in the DR and NAC shell. In the DR, Fos-induction by stress largely overlapped with tryptophan hydroxylase (TrpH), indicating activation of serotonergic neurons. Of NAC shell neurons activated during stress-induced reinstatement of alcohol seeking, about 30% co-expressed dynorphin (DYN), while 70% co-expressed enkephalin (ENK). Few (<1%) activated NAC shell neurons coexpressed choline acetyltransferase (ChAT), which labels the cholinergic interneurons of this region. Infusion of the NK1R antagonist L822429 into the NAC shell blocked stress-induced reinstatement of alcohol seeking. In contrast, L822429 infusion into the DR had no effect, suggesting that the influence of NK1R signaling on neuronal activity in the DR is indirect. Taken together, our results outline a potential pathway through which endogenous NK1R activation mediates stress-induced alcohol seeking.
Rectal prolapse in older children associated with behavioral and psychiatric disorders.

Purpose Rectal prolapse (RP) beyond infancy is challenging, and despite surgical correction, recurrences are not uncommon, suggesting that underlying contributing processes may have a role. This study highlights a previously poorly recognized relationship between RP in older children and behavioral/psychiatric disorders (BPD). We describe the incidence of recurrence and use of behavioral, psychological and physical therapeutic tactics in a multidisciplinary approach to pediatric RP.
Preoperative Assessment and Orbital Decompression Surgery in Patients with Graves’ Ophthalmopathy

Many of the signs and symptoms of Graves’ ophthalmopathy result from a discrepancy between the increased volume of the swollen orbital contents and the fixed volume of the bony orbit. While the natural history of the disease includes spontaneous improvement for most and for those patients who require some form of treatment, therapeutic efforts to address this imbalance exist. One can attempt to “shrink” the swollen tissues with corticosteroids, radiation therapy, or immunosuppression. Alternatively the volume of the bony orbit can be expanded by surgically decompressing various walls of the orbit. The amount of proptosis reduction varies according to the number of orbital walls decompressed. There are many different techniques of surgical orbital decompression and the choice of procedure is often surgeon/institution specific. This chapter reviews some of the differential diagnostic considerations encountered in the preoperative evaluation of patients with Graves’ ophthalmopathy along with a discussion of the various types of orbital decompression.
Laparoscopic Staged Roux-en-Y: A Staged Procedure for Super-Super Obese Patients

Laparoscopic Roux-en-Y gastric bypass in the super-super obese (BMI >60 kg/m) population can be challenging. Factors that contribute to the technical diffi culty include male gender, android body habitus, and high BMI. Men often have an android body habitus with high content of visceral fat, which increases intra-abdominal pressure and reduces intraoperative laparoscopic visualization. In addition, android body habitus and high BMI are often associated with fatty liver disease and enlarged liver lobes that may obscure visualization of the gastroesophageal junction. All of these factors can contribute to the degree of intraoperative technical diffi culty and should be weighed in the selection of appropriate patients to undergo laparoscopic gastric bypass. Although a high BMI is not in itself a contraindication to surgery, laparoscopic gastric bypass in the super-super obese can be associated with a higher morbidity and mortality. In an effort to minimize perioperative morbidity, the concept of a two-stage operation was developed. The initial two-stage procedure consists of a sleeve gastrectomy (fi rst stage) followed by an interval Roux-en-Y gastric bypass or duodenal switch. However, the sleeve gastrectomy can still be challenging in the super-super obese, particularly in patients with an enlarged liver from nonalcoholic steatohepatitis or liver cirrhosis obscuring visualization of the gastroesophageal junction near the angle of His. The alternative two-stage procedure is the staged Roux-en-Y, which consists of a modifi ed Roux-en-Y operation with construction of a larger gastric pouch and a low gastrojejunal anastomosis. Construction of a large gastric pouch avoids the diffi cult dissection of the angle of His. The construction of a low gastrojejunal anastomosis minimizes tension on the anastomosis and hence reduces the chance for leaks. In the second stage, 6 to 12 months later, the volume of the gastric pouch is reduced by performing a sleeve gastrectomy of the gastric fundus.
Capturing Engineering Knowledge: An Approach to Visual Programming in CAD Environment

Abstract We present a CAD system, named GIPS (Graphic Interactive Parametric System), able to automatically generate CAD applications and based on an approach which integrates computer aided design phase with an automatic generator of executable code. The designer is aided by GIPS to identify the problem solution and to describe it by means of “engineering drawing language”.
T1 BACTERIOPHAGE PRODUCTION IN ESCHERICHIA COLI

Feiner, Rose R. (Columbia University, New York, N.Y.) and Solon A. Ellison. T1 bacteriophage production in Escherichia coli. J. Bacteriol. 85:7–11. 1963.—Progeny released from complexes formed between unirradiated Escherichia coli strain Bs-1 and ultraviolet (UV)-irradiated phage T1 were equally infective for strains B and Bs-1, and were therefore not hostmodified. The capacity of Bs-1 for unirradiated or irradiated T1 is relatively insensitive to UV irradiation, as compared with that of strains B and B/r. In all three strains of E. coli, B, B/r, and Bs-1, the UV sensitivity of the capacity for phage T1 is independent of the UV sensitivity of colony-forming ability. These findings are discussed in relation to the partial genetic homology hypothesis.
From the Editors: Rebranding and Community Building

The backstory to this editorial can be traced to a meeting over coffee on a rainy Sunday in Manhattan in December 2012. It followed a series of email exchanges that emerged as a result of the decis...
Evidence-Based Policymaking: Insights from Policy-Minded Researchers and Research-Minded Policymakers

This book is for those who believe that good government should be based on hard evidence, and that research and policy ought to go hand-in-hand. Unfortunately, no such bond exists. Rather, there is a substantial gap, some say chasm, between the production of knowledge and its utilization. Despite much contrary evidence, the authors propose there is a way of doing public policy in a more reflective manner, and that a hunger for evidence and objectivity does exist. The book is pragmatic, drawing on advice from some of the best and brightest informants from both the research and policy communities. In their own voices, researchers provide incisive analysis about how to bridge the research/policy divide, and policymakers provide insights about why they use research, what kind is most useful, where they seek it, and how they screen its quality. The book breaks through stereotypes about what policymakers are like, and provides an insiders’ view of how the policy process really works. Readers will learn what knowledge, skills, approaches, and attitudes are needed to take research findings from the laboratory to lawmaking bodies, and how to evaluate one’s success in doing so. The book’s balance between theory and practice will appeal to students in graduate and upper-level undergraduate courses in family studies and family policy, educational policy, law, political science, public administration, public health, social work, and sociology. This book will also be of interest to researchers who want to bring their ideas into policy debate and to those who work with policymakers to advance an evidence-based policy agenda.
An introduction to the use of group theoretic techniques in scattering

An introduction to the use of group theoretic techniques in scattering is presented. In particular, the role of dynamic symmetries in the analysis of scattering data is discussed.
Laser-mediated cell ablation during post-implantation mouse development

BACKGROUND: Laser-mediated cell ablation is a powerful tool that has been used to understand cell fate in a variety of externally developing organisms but has not been used during mammalian post-implantation development. RESULTS: We describe a method pairing laser ablation with murine embryo culture and establish parameters that can be used to precisely ablate cells in the selected field with minimal disruption to adjacent cells or the underlying cell matrix. Ablation of a large domain of endoderm, followed by ∼1 day of culture results in a phenotypically normal embryo and gut tube, indicating that laser ablation is compatible with normal development. We next focused on one of the three precursor populations that have been shown to produce the liver bud. Ablations of a single progenitor domain result in a unilateral delay in the liver bud while the contralateral side is unaffected. CONCLUSIONS: We demonstrate that laser ablation is a specific and useful technique for studying cell fate in the mouse embryo. This method represents a powerful advance in developmental studies in the mouse and can be used to provide information on the specification of organs, differentiation, cell migration, and vital tissue interactions during development. Developmental Dynamics, 242:1202–1209, 2013. © 2013 Wiley Periodicals, Inc.
Histomorphologic assessment of formalin substitute fixatives for diagnostic surgical pathology.

Abstract Context.—In 1987, the Formaldehyde Standard became law in the United States, alerting laboratory workers to the potential carcinogenicity of formaldehyde. As a result, a variety of proprietary fixatives were developed for use in surgical pathology. Objective.—To assess histomorphology with different formalin substitute fixatives. Design.—Four experienced board-certified surgical pathologists examined 7 specimens (hepatocellular carcinoma, ovarian sex cord/stromal tumor, myxoid liposarcoma, uterine endometrioid adenocarcinoma, splenic follicular hyperplasia, infiltrating mammary carcinoma, and cecal signet ring carcinoma) fixed with formalin and 5 proprietary fixatives advertised as formalin replacements. In a blind study, the pathologists rated cellular outlines, cytoplasmic detail, nuclear detail, erythrocyte integrity, lymphocyte integrity, overall morphology, and overall staining in each case. Results.—Formalin received the highest overall morphology and staining scores, followed by Glyo-Fixx,...
Poetry and Poetic Metaphor in Teaching Leadership and Ethics

One result of the overextended and frenetic academic and managerial environments in which we find ourselves is the tendency to compartmentalize many discussions into rigidified and limiting formats. This is a particular problem with ethical discourse, where ethical concerns often exist in tension with managerial rhetoric. Pressurized command and control approaches, found in both business schools and organizations, often lack the linguistic resources to enable managers to discuss the subtle, ethical dimensions of the situations they face. The current article sketches an approach to this problem through the use of poetic metaphor.
Family Violence in the United States: Defining, Understanding, and Combating Abuse

Preface and Acknowledgments 1. Issues in the Definition of Family Violence and Abuse Definitional Issues Ecological Models of Maltreatment Summary 2. Cultural Contexts of Family Violence The Contemporary Context The Broader Ecological Context Summary 3. Cultural Contexts: Religion Religion in the United States Religious Affiliation and Religious Conservatism as Risk Factors for Family Violence Positive Roles of Religion and Religiosity The Response of Religious Institutions to Spousal Abuse Summary 4. Child Physical Abuse Scope of the Problem Predictors and Correlates Consequences Prevention and Intervention Summary 5. Child Sexual Abuse Scope of the Problem Predictors and Correlates Consequences Prevention and Intervention Summary 6. Child Neglect and Psychological Maltreatment Neglect Psychological Maltreatment Summary 7. Wife Abuse Physical Maltreatment Psychological Maltreatment Sexual Abuse Prevention and Intervention Summary 8. Husband Abuse Physical Abuse Psychological Maltreatment Prevention and Intervention Summary 9. Abuse in Gay/Lesbian/Bisexual/Transgender Relationships Scope of the Problem Predictors and Correlates Consequences Prevention and Intervention Summary 10. Elder Abuse Scope of the Problem Predictors and Correlates Consequences Prevention and Intervention Summary 11. Hidden Types of Family Violence: Abuse of Siblings, Parents, and People With Disabilities Sibling Abuse Parent Abuse Abuse of Family Members With Disabilities Summary 12. Responding Effectively to Family Violence Responding to Child Maltreatment The Response to Wife Abuse Husband Abuse and the Criminal Justice System Maltreated Elders in the Criminal Justice System Summary References Author Index Subject Index About the Authors