cssi/SciSciGPT-SciSciNet huggingface dataset:
Towards a Taxonomy of Transatlantic Romanticism(s)

In ‘Transatlanticism Now,’ Laura Stevens suggests that scholars should construct a taxonomy of the field. This article takes its cue from Stevens and classifies existing research as well as outlines categories for future scholarship, based on where knowledge of the field runs threadbare and where there is the most pressing need for scholarly study. Future work on transatlantic romanticism must incorporate more studies of women and people of color as well as interdisciplinary and intra-disciplinary connections (especially to transnational, transpacific, transoceanic, and postcolonial studies). The article seeks to provide the most complete survey and definition of transatlantic romanticism to date as well as a good starting point for all researching and teaching in the field. Based on a firm belief that further scholarship is needed to define this field, this article is an open call for more work on transatlantic romanticism(s) and the development of existing categories as well as new ones. The following categories are interdependent, not hierarchical; they do not seek to differentiate between, say, British and American Romanticism, but to set up comparatist frameworks that link, rather than separate, transatlantic romanticisms: ‘Imag-I-Nations: race, gender, colonialism, notions of national identity and the self’; ‘Circum-Atlantic sisterhood and brotherhood: Atlantic constructs of femininity and masculinity’; ‘Revolution, Rebellion, and Reform: communities of interpreters and literary history’; ‘Transatlantic Greenery: nature, ecology, and the politics and poetics of preservation and pastoral’; ‘Trans(atlantic) migration of souls: conversations with other wor(l)ds’; ‘Transatlantic romanticisms and science: the physical and the mind’; ‘Emotion and sensibility: transatlantic discourses of sympathy, sentiment, and feeling’; ‘Transatlantic travel writing: the ethnocentric Atlantic and international interventions’; ‘Literary and cultural aesthetics and genres: influence, confluence, and difference’; and ‘Transatlantic Translation: language, diction, linguistics, and stylistics.’
Newer Insights into the Biochemical Physiology of the Renin–Angiotensin System: Role of Angiotensin-(1-7), Angiotensin Converting Enzyme 2, and Angiotensin-(1-12)

Knowledge of the mechanisms by which the rennin–angiotensin system contributes to cardiovascular pathology continues to advance at a rapid pace as newer methods and therapies uncover the nature of this complex system and its fundamental role in the regulation of blood pressure and tissue function. The characterization of the biochemical pathways and functions mediated by angiotensin-(1-7) [Ang-(1-7)], angiotensin converting enzyme 2 (ACE2), and the mas receptor has revealed a vasodepressor and antiproliferative axis that within the rennin–angiotensin system opposes the biological actions of angiotensin II (Ang II). In addition, new research expands on this knowledge by demonstrating additional mechanisms for the formation of Ang II and Ang-(1-7) through the existence of an alternate form of the angiotensinogen substrate [angiotensin-(1-12)] which generates Ang II and even Ang-(1-7) through a non-renin dependent action. Altogether, this research paves the way for a better understanding of the intracellular mechanisms involved in the synthesis of angiotensin peptides and its consequences in terms of cell function in both physiology and pathology.
The European Parliament and environmental legislation: The case of chemicals

The paper studies the impact of the EP on legislation on chemical pollutants in- troduced under the Cooperation procedure. A series of formal and informal analyses have predicted from significant impact of the EP, to limited impact (only in the second round) to no impact at all. Through the analysis of Parliamentary debates as well as Commission and Parliamentary committee documents, we are able to assess the significance of different amendments, as well as the degree to which they were introduced in the final decision of the Council. Our analysis indicates first that less than 30% of EP amendments are insignificant, while 15% are important or very important; second, that the probability of acceptance of an amendment is the same regardless of its significance. Further analysis indicates two sources of bias of aggregate EP statistics: several amendments are complementary (deal with the same issue in different places of the legal document), and a series of amendments that are rejected as inadmissible (because they violate the legal basis of the document or the germainess require- ment) are included in subsequent pieces of legislation. We calculate the effect of these biases in our sample, and find that official statistics underestimate Parliamentary influence by more than 6 percentage points (49% instead of 56% in our sample). Finally, we compare a series of observed strategic behaviors of different actors (rapporteurs, committees, floor, Commission) to different expectations generated by the literature.
Meta-analyses of agreement between diagnoses made from clinical evaluations and standardized diagnostic interviews.

Standardized diagnostic interviews (SDIs) have become de facto gold standards for clinical research. However, because clinical practitioners seldom use SDIs, it is essential to determine how well SDIs agree with clinical diagnoses. In meta-analyses of 38 articles published from 1995 to 2006 (N = 15,967 probands), mean kappas (z-transformed) between diagnoses from clinical evaluations versus SDIs were 0.27 for a broad category of all disorders, 0.29 for externalizing disorders, and 0.28 for internalizing disorders. Kappas for specific disorders ranged from 0.19 for generalized anxiety disorder to 0.86 for anorexia nervosa (median = 0.48). For diagnostic clusters (e.g. psychotic disorders), kappas ranged from 0.14 for affective disorders (including bipolar) to 0.70 for eating disorders (median = 0.43). Kappas were significantly higher for outpatients than inpatients and for children than adults. However, these effects were not significant in meta-regressions. Conclusions: Diagnostic agreement between SDIs and clinical evaluations varied widely by disorder and was low to moderate for most disorders. Thus, findings from SDIs may not fully apply to diagnoses based on clinical evaluations of the sort used in the published studies. Rather than implying that SDIs or clinical evaluations are inferior, characteristics of both may limit agreement and generalizability from SDI findings to clinical practice. Copyright © 2009 John Wiley & Sons, Ltd.
Saturation Mutagenesis of the TATA Box and Upstream Activator Sequence in the Haloarchaeal bop Gene Promoter

Degenerate oligonucleotides were used to randomize 21 bp of the 53-bp minimal bop promoter in three 7-bp segments, including the putative TATA box and the upstream activator sequence (UAS). The mutagenized bop promoter and the wild-type structural gene and transcriptional terminator were inserted into a shuttle plasmid capable of replication in the halophilic archaeon Halobacterium sp. strain S9. Active promoters were isolated by screening transformants of an orange (Pum− bop) Halobacterium mutant for purple (Pum+ bop+) colonies on agar plates and analyzed for bop mRNA and/or bacteriorhodopsin content. Sequence analysis yielded the consensus sequence 5′-tyT(T/a)Ta-3′, corresponding to the promoter TATA box element 30 to 25 bp 5′ of the transcription start site. A putative UAS, 5′-ACCcnactagTTnG-3′, located 52 to 39 bp 5′ of the transcription start site was found to be conserved in active promoters. This study provides direct evidence for the requirement of the TATA box and UAS for bop promoter activity.
Harmonizing Measures of Cognitive Performance Across International Surveys of Aging Using Item Response Theory.

Objective: To harmonize measures of cognitive performance using item response theory (IRT) across two international aging studies. Method: Data for persons ≥65 years from the Health and Retirement ...
Targeting CD138−/CD20+ Clonogenic Myeloma Precursor Cells Decreases These Cells and Induces Transferable Antimyeloma Immunity

Abstract This phase Ib clinical trial evaluated whether pretargeting of CD20+ clonogenic myeloma precursor cells (CMPCs) with anti-CD3 × anti-CD20 bispecific antibody-armed T cells (BATs) before autologous stem cell transplantation (SCT) in patients with standard-risk and high-risk multiple myeloma would induce antimyeloma immunity that could be detected and boosted after SCT. All 12 patients enrolled in this study received 2 BATs infusions before SCT, and 4 patients received a booster infusion of BATs after SCT. Pretargeting CD138−/CD20+ CMPCs with BATs before SCT was safe and reduced levels of CMPCs by up to 58% in the postinfusion bone marrow in patients who remained in remission. Four of 5 patients who remained in remission had a >5-fold increase in IFN-γ enzyme-linked immunospot responses. SOX2 antibody increased after BATs infusions and persisted after SCT. The median anti-SOX2 level at 3 months after SCT was 28.1 ng/mL (range, 4.6 to 256 ng/mL) in patients who relapsed and 46 ng/mL (range, 28.3 to 73.3 ng/mL) in patients who remained in remission. The immune correlates suggest that infusions of targeted T cells given before SCT were able to reduce CMPC levels and induced cellular and humoral antimyeloma immunity that could be transferred and boosted after SCT.
THE GENERAL PERTURBATIONAL THEORY OF SPACE-HARMONIC TRAVELING-WAVE ELECTRON INTERACTION

Publisher Summary This chapter explains small-signal equations for traveling-wave interaction of an electron beam with an adjacent space-harmonic circuit, including the effects of competition between the first forward space harmonics of the forward and backward total waves on the circuit. The basic equation for the perturbation of the propagation constant is found to be a quartic, having as its most important given quantity a frequency offset parameter, which for this study serves the same purpose that Pierce's overdrive parameter serves in the study of forward-wave interaction in a helix. Dealing with the electrokinetic interaction in differential-equation form has made possible quantitative statement of the very-small-signal nature of the small signal limitation. In proceeding through the analysis, it has preserved separate use of concept as between the differential equations for interaction dynamics and the field-theory analysis of beam-circuit coupling. It has retained the generality of the four-wave perturbational possibility through the longitudinal boundary-value treatment, with appropriate specialization to the 3 + 1 and 1 + 3 backward-wave and forward-wave analyses; there is emphasized by spatial phasor illustrations and a start-oscillation cusp chart the essentiality of a phase interference pattern to backward-wave amplification and oscillation.
Using Green Fluorescent Protein (GFP) Reporter Genes in RNAlater™ Fixed Tissue

Plants in an orbital environment experience conditions that are distinctly unlike the earth-bound environments that have directed their evolution on Earth. This presents a unique opportunity to examine biological responses, particularly those involved in integrating gravity as a force shaping biological systems. One means of measuring these adaptive responses is to monitor the expression of genes that allow survival in those peculiar environments. In a recent series of spaceflight experiments conducted on the International Space Station (ISS) we utilized Arabidopsis thaliana (Arabidopsis) plants engineered with specific gene promoters driving to Green Fluorescent Protein (GFP). These biological sensor plants are referred to as TAGES, an acronym for Transgenic Arabidopsis Gene Expression System. One component of the TAGES Spaceflight experiment was the use of several different GFP reporter gene constructions to record tissue-specific changes in the patterns of gene expression in real time. Another component was the evaluation of genome-wide changes in these plants, a goal that required the use of the nucleic acid preservative RNAlater™ (Ambion).
Heterogeneity of human whole blood platelet subpopulations. II. Use of a subhuman primate model to analyze the relationship between density and platelet age.

A subhuman primate model was developed to ascertain whether or not platelet heterogeneity could be explained by aging in the peripheral circulation. Density-dependent platelet cohorts, postulated to represent cells of different ages, were isolated on isosmolar arabinogalactan gradients and labeled with radiochromium. Mean platelet lifespan was measured for the different density cohorts, and simultaneous sequential density distribution analysis was performed to follow changes in cell density during aging. The average mean lifespan of light platelets was 74.6 hr, compared to 313.6 hr for heavy platelets. After injection, labeled light platelets were recovered only in the gradient light region, in contrast to labeled heavy platelets, which were initially restricted to the dense region and progressively migrated to the light region during their lifespan. This study supports the hypothesis that platelet age in unstressed primates correlates with cell density and provides a rationale for the use of “age-dependent” markers to estimate platelet turnover rates.
Comparison of the 3 approaches on detection of syphilis

Objective To compare the specificity of three kinds of serological approaches on detecting treponema pallidum antibody and the clinical application values in clinic.Methods Three approaches including TRUST,TPPA,ELISA were used to detect 228 serum specimens.Results The sensitivities of the three approaches(TRUST,TPPA,ELISA) were 85.83%,98.33%,99.17%;The specificities of the three approaches were 95.37%,99.07%,98.15% respectively.The sensitivity and specificity of TRUST were lower than those of the TPPA(P0.05);The sensitivity and specificity of ELISA were not lower than those of the TPPA(P0.05);The sensitivity of TRUST was lower than that of the ELISA(P0.05),but the specificity of TRUST was not lower than that of the ELISA(P0.05).Conclusion It is suggested that TPPA and ELISA are the first choice on detecting syphilis antibody.
Numerical simulation of diurnal variation of major pollutants with WRF-Chem model in Tianjin

The numerical simulation of the temporal variation and spatial distribution of the concentrations of CO, NOx, O3 and PM2.5 were conducted with WRF-Chem model in Tianjin. The uncertainties of the model were evaluated by comparing with the observed data. The temporal variations and spatial distribution of the concentrations of CO, NOx, O3 and PM2.5 were significant in Tianjin area. Concentrations of O3 were higher at noon and lower at night, while concentrations of CO, NOx and PM2.5 were higher in the morning and night, and lower in the afternoon. In addition, concentrations of O3 in urban area were higher than it in suburban area in the early afternoon, but the reverse was true at nighttime. The concentrations of CO, NOx and PM2.5 in urban area were higher than it in the suburban area all the time. On the typical day with the northeastern wind, the four pollutants above were mainly from the local sources, the long distance transportation of these pollutants was insignificant.
Vitamin B12 homoeostasis after haemorrhage in the rat: the importance of skeletal muscle

1. The effects of haemorrhage on vitamin B12 (cobalamin) homoeostasis have been studied in rats with and without prior administration of 57Co-labelled cyanocobalamin. 2. Arteriovenous differences in radioactivity and endogenous B12 were measured across the thigh extensor muscles. Radioactivity and endogenous B12 were also measured in skeletal muscle, liver and kidney. 3. Haemorrhage induced a marked rise in circulating B12 with a concomitant loss of the vitamin from skeletal muscle and liver, but in kidney there was a net gain. Restoration of the blood volume with autologous plasma did not prevent release of B12 from tissues. 4. The results suggest that vitamin B12 reserves may be seriously depleted by the wasting of skeletal muscle.
Analysis of responses to angiotensin peptides in the hindquarters vascular bed of the cat

Responses to angiotensin I, II, III, and IV, des-Asp1-angiotensin I, and (p-amino-Phe6)-angiotensin II were compared in the hindquarters vascular bed of the cat. The peptides produced dose-related ...
Solitary Cystic Lymphangioma of the Retroperitoneum

AbstractWe present 2 cases of solitary cystic lymphangioma of the retroperitoneum. The non-specific clinical picture is demonstrated again but the pathologic features of both tumors are characteristic. Surgical treatment was successful in both instances.
Development Towards a New Nighttime Aerosol Retrieval Scheme Using VIIRS DNB

Preliminary studies have been conducted to develop a new nighttime aerosol optical depth retrieval capability using observations from VIIRS Day/Night Band targeted primarily for aerosol analysis and forecasting applications.
Endoscopic Retrograde Cholangiopancreatography (ERCP)

Endoscopic retrograde cholangiopancreatography (ERCP) is used to diagnose and intervene on a variety of pancreaticobiliary pathologies. It is a mainstay of therapy for cholangitis, choledocholithiasis, initial treatment of pancreatic and biliary strictures, and several post-cholecystectomy indications. Advances in technique and equipment now enable targeted biopsies and stone treatment under direct endoscopic visualization. ERCP can be safely performed in patients with altered foregut anatomy by skilled teams using modified equipment and techniques, including transgastric approaches in patients after roux-en-y gastric bypass. Despite expanding indications and increased procedural sophistication, operators should remain mindful of the underlying principles of careful endoscopic access, controlled cannulation and sphincterotomy, and image-guided intervention. Procedural risks, most notably post-ERCP pancreatitis, should be carefully weighed against the numerous potential benefits of ERCP for minimally invasive diagnosis and treatment of disorders of the hepatobiliary and pancreatic ductal systems.
The influence of magnetic fields on dielectric surface flashover

The influence of low-amplitude magnetic fields, in a variety of configurations, on pulsed dielectric surface flashover was investigated. These variations included DC magnetic fields, pulsed magnetic fields simulating conditions for magnetic self-insulation, and different environments, geometries, dielectric materials, and orientations of the magnetic field. For field amplitudes of 0.3 T, typically a doubling of the flashover voltage is observed if the E*B drift is away from the surface. For flashover in vacuum, it is sufficient to place permanent magnets in the cathode vicinity to increase the flashover voltage. The observations are consistent with the saturated surface secondary avalanche model and electron-induced gas desorption. The pulse shape of light emission during the prebreakdown phase depends on the orientation and amplitude of the magnetic field and shows that electron trajectories above the surface are altered by magnetic fields. >
Identifying evidence of cardio-renal syndrome in patients with Duchenne muscular dystrophy using cystatin C

Abstract Patients with Duchenne muscular dystrophy (DMD) develop dilated cardiomyopathy and are at risk for kidney injury. Creatinine based estimated glomerular filtration rate (eGFR) is limited by low muscle mass with low serum creatinine levels in DMD. We assessed the relationship between cardiac function, modified Schwartz eGFR and cystatin C eGFR in patients with DMD. Ninety-three patients with DMD were screened for renal dysfunction in an outpatient neuromuscular clinic. Patients with new nephrotoxic medications, recent hospitalization or decompensated heart failure were excluded from the analysis. Eleven (12%) patients had evidence of renal dysfunction identified by cystatin C eGFR, while no patients had renal dysfunction by Schwartz eGFR. There was no significant correlation between cystatin C eGFR and age (r = −0.2, p = 0.11), prednisone dose (r = 0.06, p = 0.89) or deflazacort dose (r = −0.01, p = 0.63). There was a significant correlation between left ventricular ejection fraction and cystatin C GFR among patients with chronic left ventricular dysfunction (r = 0.46, p
Character and Characterization

In turning toward further study of actual characterizations we must consider them under a classification that differs significantly from those already introduced. We have said some of the essential things about the meaning which attaches to appraisive terms, but there are also special considerations about particular terms or particular classes of terms that must be taken into account in their analysis. We have alluded to the important differences between commendatives and ordinary characterizations which compel us to offer a different account of their respective meanings. Of equal importance are the essential traits of characterization itself.
‘Greville Fane’: Portrait of a ‘Lady-Novelist’

In 1892 James wrote ‘Greville Fane’, the third story in his series on the literary life. It is as different in form and substance from its predecessors, ‘The Author of Beltraffio’ and ‘The Lesson of the Master’, as they are from each other. It is the most extensive of James’s comic portraits of ‘lady novelists’, preceding such satirically drawn characters as Guy Walsingham (who also takes a masculine pen name) in ‘The Death of the Lion’; Jane Highmore in ‘The Next Time’; and Gwendolyn Erme in ‘The Figure in the Carpet’. ‘Greville Fane’ also precedes James’s developing by the end of the 1890s a more sympathetic view of women as novelists and of their likely contributions to the art of fiction.1 It is unique among James’s fictions about writers in that it is not a conventionally conceived dramatic fiction, but rather, as James called it, an ‘anecdote’, a ‘minor miracle of foreshortening’ (Volume XVI, p. vii). Moreover, despite its comic perspective, it is the first fiction through which James dramatises his ever-clearer belief about the responsibility of the critic to respond with flexibility and humanity to his subject. His narrator in ‘Greville Fane’ is an illustration of the critic James had described in his essay ‘Criticism’ in the preceding year:
The pendulous, belly-flopping landing acrobatics of tree frogs

![Graphic][1] Frogs jump. They're darned good at it. Because of this, they've been one of the key groups used to study the oh-so-important first phase of jumping – take off. But what goes up must come down and if you're a tree-dwelling frog, that down can be 10 or more meters below if you
A prospective pilot study of genome-wide exome and transcriptome profiling in patients with small cell lung cancer progressing after first-line therapy.

BACKGROUND Small cell lung cancer (SCLC) that has progressed after first-line therapy is an aggressive disease with few effective therapeutic strategies. In this prospective study, we employed next-generation sequencing (NGS) to identify therapeutically actionable alterations to guide treatment for advanced SCLC patients. METHODS Twelve patients with SCLC were enrolled after failing platinum-based chemotherapy. Following informed consent, genome-wide exome and RNA-sequencing was performed in a CLIA-certified, CAP-accredited environment. Actionable targets were identified and therapeutic recommendations made from a pharmacopeia of FDA-approved drugs. Clinical response to genomically-guided treatment was evaluated by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. RESULTS The study completed its accrual goal of 12 evaluable patients. The minimum tumor content for successful NGS was 20%, with a median turnaround time from sample collection to genomics-based treatment recommendation of 27 days. At least two clinically actionable targets were identified in each patient, and six patients (50%) received treatment identified by NGS. Two had partial responses by RECIST 1.1 on a clinical trial involving a PD-1 inhibitor + irinotecan (indicated by MLH1 alteration). The remaining patients had clinical deterioration before NGS recommended therapy could be initiated. CONCLUSIONS Comprehensive genomic profiling using NGS identified clinically-actionable alterations in SCLC patients who progressed on initial therapy. Recommended PD-1 therapy generated partial responses in two patients. Earlier access to NGS guided therapy, along with improved understanding of those SCLC patients likely to respond to immune-based therapies, should help to extend survival in these cases with poor outcomes.
First-principles Green-Kubo method for thermal conductivity calculations

Author(s): Kang, J; Wang, LW | Abstract: We present a first-principles approach to calculate the phonon thermal conductivity based on the Green-Kubo formalism. In this approach, the density functional theory energy is distributed to each atom, and a two-step method in the molecular dynamics is introduced to avoid the atomic position R wrapping problem in a periodic system when the heat current is calculated. We show that this first-principles Green-Kubo approach is particularly suitable for disordered systems like amorphous and liquid, where the thermal conductivities are small due to strong phonon scattering but difficult to be calculated using anharmonic interaction energy. We have applied our method to liquid Ar, liquid Si, and amorphous Si. The calculated thermal conductivities agree well with previous theoretical and experimental results. We have also compared our method to previous works combining first-principles simulations with the Green-Kubo formalism.
The Public Health Burden of Lymphatic Malformations in Children: National Estimates in the United States, 2000-2009.

Abstract Objective: Describe inpatient resource utilization trends in children with lymphatic malformations using a national database. Data source: Kids' inpatient database, years 2000–2009. Method...
Detecting Changes in Twitter Streams using Temporal Clusters of Hashtags.

Detecting events from social media data has important applications in public security, political issues, and public health. Many studies have focused on detecting specific or unspecific events from Twitter streams. However, not much attention has been paid to detecting changes, and their impact, in online conversations related to an event. We propose methods for detecting such changes, using clustering of temporal profiles of hashtags, and three change point detection algorithms. The methods were tested on two Twitter datasets: one covering the 2014 Ottawa shooting event, and one covering the Sochi winter Olympics. We compare our approach to a baseline consisting of detecting change from raw counts in the conversation. We show that our method produces large gains in change detection accuracy on both datasets.
The Nerve Net of the Actinozoa: IV. Facilitation and the "Staircase"

1. The relation of the "staircase" effects in the vertebrate heart, in the bell of Medusae and in the sphincter of Calliactis is discussed. Whereas in the heart the effect is due to an intrinsic increase of contractility of the whole contractile tissue, evidence is brought to show that the staircase in Calliactis and in Medusae depends upon neuromuscular facilitation by which each stimulus in a series reaches more and more individual muscle fibres. 2. The relation of different types of contraction in coelenterate muscle is discussed. It is shown how this depends upon the relation of the stimulation interval necessary for a facilitated response and the duration of a complete contraction and relaxation of the muscle. If these are about equal the step-like contraction of the sphincter of Calliactis results; if the facilitation interval is long a staircase similar to that of a Medusa bell is produced; if the duration of the twitch is relatively long a smooth contraction as in the mesenteric muscle of Calliactis is produced.
Association of Dermatologist Density With the Volume and Costs of Dermatology Procedures Among Medicare Beneficiaries

Importance The persistent shortage of dermatologists in the United States affects access to care and patient outcomes. Objective To characterize the effect of geographic variations in dermatologist density on the provision of dermatology procedures within Medicare. Design, Setting, and Participants This was a cross-sectional study using the 2013 Medicare Provider Utilization and Payment Database. Dermatology-related procedures were defined by the top 50 billing codes accounting for more than 95% of procedures billed by dermatologists. Billing codes corresponding to evaluation and monitoring visits and dermatopathology were excluded. Total costs were estimated from the Centers for Medicare & Medicaid Services physician fee schedule, based on the nonfacility national payment amount with no modifiers. Nationally representative administrative database that includes 100% of charges billed by noninstitutional clinicians covered under Medicare Part B. A total of 10 391 dermatologists practicing within the 50 states and Washington, DC, were included. The Medicare-eligible population was defined as all persons 65 years or older. Exposures Density of dermatologists, categorized into first (5.3 per 100 000 persons ≥65 years) through fifth (54.8 per 100 000 persons ≥65 years) quintiles. Main Outcomes and Measures Utilization of dermatology procedures (mean volume per 100 000 persons ≥65 years) and total cost (mean amount billed per person ≥65 years) by clinician type across quintiles of dermatologist density. Results In 2013, dermatologists billed Medicare for 28 million procedures costing $2.21 billion. Mean billed amount by dermatologists per person 65 years or older was $15.87 in the lowest-density quintile vs $92.02 in the highest-density quintile. This trend suggests that each interval increase of 10 dermatologists per 100 000 persons 65 years or older is correlated with a $14.81 increase in Medicare spending on dermatology procedures (95% CI, 8.28-21.34;P = .005). Utilization of these procedures differed among clinician types, with dermatologists largely performing destruction of premalignant lesions and PCPs primarily doing injections. Conclusions and Relevance There is evidence of supply-sensitive variation in the provision of dermatology procedures for the Medicare-eligible population; higher dermatologist density is correlated with increased utilization of dermatology procedures and subsequent billed charges to Medicare. Further research is needed to determine the effect of such variations on outcomes and whether incentives can better align dermatologists with areas of clinical need.
Adaptive Bayesian Time-Frequency Analysis of Multivariate Time Series

This article introduces a nonparametric approach to multivariate time-varying power spectrum analysis. The procedure adaptively partitions a time series into an unknown number of approximately stat...
Introduction: Why Ethics?

What is ethics? Ethics is a discipline that deals with what is good and bad and with moral duty and obligation. It encompasses the principles and rules governing the standards of conduct of an individual or group, such as a community or a profession. Sometimes referred to as moral philosophy, it is the study of the general nature of morals and of the specific moral choices to be made by a person or group.
Calspermin is a Testis Specific Calmodulin-Binding Protein Closely Related to Ca2+/Calmodulin-Dependent Protein Kinases

Calmodulin regulates a wide variety of cellular functions by interacting with its binding proteins or enzymes 1. Based on studies with a number of naturally occuring peptides that bind calmodulin with high affinity, it has been predicted that both ionic and hydrophobic interactions are involved in the association and that a general characteristic of a calmodulin-binding peptide is the ability to form a basic, amphiphilic helix 2–5. Indeed as the sequence of calmodulin-binding proteins have become known, the basic, amphiphilic helix has been shown to be the one common feature of the calmodulin-binding domain 6–16.
Stem Cell Chromatin Patterns and DNA Hypermethylation

Normal development requires carefully orchestrated cellular remodeling on both a global and gene-specific/tissue-specific level. Heritable changes in gene expression that occur independently of alterations in the primary DNA sequence are deemed “epigenetic,” and are largely characterized by a tightly regulated program of active and repressive histone modifications. In this chapter, we will discuss the histone modifications that help modulate gene expression during development, as well as the normal stem/progenitor cell epigenetic remodeling proteins, including polycomb group (PcG) proteins, which control these modifications. Intriguingly, the methylation of CpG dinucleotides in DNA also plays a critical role during both normal and malignant epigenetic reprogramming. DNA methylation is a critical mediator of both X-chromosome inactivation and paternal and maternal imprinting, the variable regulation of tissue/cell specific activation of genes required for successful differentiation of alternate cell lineages, and the permanent silencing of genes required for stem/progenitor cell maintenance and pluripotency. Aberrant DNA methylation is a key component of the malignant epigenetic programs that are pervasive in all types of cancer and are thought to contribute to tumor initiation and progression. The clustering of silenced genes within single cell pathways and the remarkable frequency with which epigenetically silenced genes are being identified within any given cancer type begs the question of whether gene silencing is a series of random events resulting in an enhanced survival of a premalignant clone, or whether silencing is the result of a directed, instructive program for silencing initiation reflective of the cells of origin for tumors. We hypothesize that a combination of both chromatin and DNA regulatory networks controlling stem cell epigenetics may go awry in cells that give rise to tumors and during tumor progression. In this regard, the current chapter stresses the hypothesis that the malignant epigenetic program is linked, at least for silencing of some cancer genes, to the epigenetic control of stem/precursor cell gene expression patterns.
Abstract 18475: Is There Any End in Sight to This Debate on the Optimal Duration of Dual Antiplatelet Therapy After Drug-eluting Coronary Stent Implantation?

Introduction: There is no end in sight to the ongoing debate on the optimal duration of dual antiplatelet therapy (DAPT) following drug-eluting coronary stent (DES) implantation. Hypothesis: Short-...
Synthetic Steganographic Series and Finance

Whenever agent Alice is in a position to send a non- trivially generated data series to agent Bob, Alice is in a position to signal Bob in various ways, including an ability to hide a message for Bob in the series. Such data series may be generated in a variety of situations, including stock prices in any time scale, patterns, textures, tilings, and virtually any processes in which seemingly random values may appear. We focus on stock-price series and demonstrate each step of the data generation and hiding process in detail, using authentic data from the underlying application to generate synthetic data that cannot be compared to data that will naturally be absent in real applications.
Effects of oral trazodone on echocardiographic and hemodynamic variables in healthy cats.

ObjectivesThe purpose of this study was to evaluate the effects of oral trazodone on echocardiographic variables, heart rate (HR) and blood pressure (BP) in healthy cats.MethodsClient-owned domesti...
Microscopic/"Backwash" Ileitis and Its Association With Colonic Disease in New Onset Pediatric Ulcerative Colitis.

Background Microscopic ileitis and its association with pancolitis in adults with ulcerative colitis (UC) have been described. The incidence of ileitis and associations with colonic disease in pediatric UC have, however, not been thoroughly investigated. This study was undertaken to examine the prevalence of microscopic ileal inflammation at the time of initial diagnosis in a cohort of children with UC. Methods We reviewed colonoscopy and biopsy data at time of diagnosis from 105 children and young adults with treatment naive UC; ileal and colonic mucosal biopsies were available on all patients. Ileal mucosal biopsies were examined for the presence and severity of ileal inflammation, and other histologic features. Concurrently obtained colonic mucosal biopsies were assessed to define the severity, distribution, and extent of disease; endoscopic and clinical follow-up data were reviewed. Results A total of 107 ileal mucosal biopsies and 693 corresponding colonic mucosal biopsies were examined. Seventeen of 105 patients (16%) were found to have ileal inflammation (mean age = 10.4 years, 59% girls), 14 (82%) of whom had histologic pancolitis. The presence of ileal inflammation was significantly associated with endoscopic pancolitis (P = 0.02). The association between histologic pancolitis, severity of active inflammation in the cecum, and ascending colon suggested a possible association with ileal inflammation (P = 0.06, 0.07, and 0.08 respectively), but did not reach statistical significance. Conclusion Patients with new onset UC may have microscopic ileal inflammation at time of diagnosis, even if the terminal ileum appears macroscopically normal. The presence of endoscopic pancolitis is associated with the presence of histologic ileitis. In contrast to existing studies in adults, an association between the presence of ileitis and the histologic severity or the histologic extent of colitis was not observed. Children with microscopic ileitis in the context of UC do not need to be reclassified as "indeterminate colitis" or Crohn disease.
Operational local join count statistics for cluster detection

This paper operationalizes the idea of a local indicator of spatial association (LISA) for the situation where the variables of interest are binary. This yields a conditional version of a local join count statistic. The statistic is extended to a bivariate and multivariate context, with an explicit treatment of co-location. The approach provides an alternative to point pattern based statistics for situations where all potential locations of an event are available (e.g., all parcels in a city). The statistics are implemented in the open source GeoDa software and yield maps of local clusters of binary variables, as well as co-location clusters of two (or more) binary variables. Empirical illustrations investigate local clusters of house sales in Detroit in 2013 and 2014, and urban design characteristics of Chicago census blocks in 2017.
Estimation of Trailer-Vehicle Articulation Angle Using 2D Point-Cloud Data

In the quest to achieving more autonomous features on articulated vehicles, such as backing up and trailer stability, the vehicles need to keep track of the angle of articulation for proper control. While there are existing approaches which estimate the angle, most of the methods require a sticker on the trailer or additional hardware, which adds to the many-sensors already on the vehicle. This study considers a typical single-trailer articulation. Our approach takes advantage of the existing radar sensors at the rear side of the vehicle. Fortunately, most vehicle manufacturers follow this design. This prevents sourcing additional hardware for the task. We demonstrate the estimation approach with simulated point clouds for one of the radars at the rear of the vehicle with a view to implementing the approach on other sensors. The methods used are ordinary least squares (OLS), principal component analysis (PCA), and maximum likelihood estimation (MLE). Based on the simulation results, all three methods were comparable for point clouds having a low variance along the vehicle's longitudinal axis. When the variance along the axis was increased, OLS had a reduced performance while the PCA and the MLE methods retained their comparable performance. Meanwhile, the MLE method required more computational resource than the PCA method.
Traumatic Pediatric Quadriceps Rupture After Medial Patellofemoral Ligament Reconstruction: A Case Report.

Case A healthy 14-year-old boy, who presented with recurrent patellar instability, underwent medial patellofemoral ligament (MPFL) reconstruction. Four weeks following this operation, the patient slipped and fell while wearing his knee brace and was found to have sustained a quadriceps tendon rupture. Conclusions We present a case of a rare, previously undescribed complication following an MPFL reconstruction in a young athlete. The etiology of this particular injury pattern may be due to a disruption of the vascular supply to the superior pole of the patella. Orthopaedic surgeons performing these reconstructions should be aware of this unusual complication.
Myelofibrosis associated with tuberculosis; a report of four cases.

Myelofibrosis (fibrotic bone marrow and, usually, an increase in megakaryocytes) is characterized by generalized pains, weakness, loss of weight, enlargement of the liver and spleen and a leuko-erythroblastic anemia. Four cases of myelofibrosis associated with generalized tuberculosis have been reviewed in detail. Autopsy examination of the 4 cases revealed acute, caseating tuberculosis which was considered to be responsible for the bone marrow and generalized fibrosis observed. A similar type of tuberculosis occurred in 7 of 91 cases of myelofibrosis reveiwed in the literature. The pathogenesis of myelofibrosis associated with tuberculosis is discussed. In the diagnosis of this syndrome, attention is called to the importance of obtaining a bone marrow biopsy and making a complete bacteriologic and pathologic study of this tissue for tuberculosis. The 4 tuberculous cases here reported as compared with 5 cases of idiopathic type, are younger, have hyperpyrexia, less splenic but greater lymph node enlargement and run a shorter course before death.
Predicting landscape-scale summer resource selection for the northern long-eared bat (Myotis septentrionalis) in Iowa

The northern long-eared bat (Myotis septentrionalis) is currently listed as threatened under the U.S. Endangered Species Act largely due to population declines resulting from the spread of white-nose syndrome in North America. White-nose syndrome was confirmed in Iowa in 2015, emphasizing a need to closely monitor populations of M. septentrionalis statewide. We applied presence-only models to predict landscape-scale resource selection by M. septentrionalis using roost tree observations and mist net captures from various research and environmental assessment projects in Iowa (2003–2015). We used a simultaneous autoregressive (SAR) model to account for residual spatial autocorrelation in our compiled data set and estimate the proportional probability of use of summer habitats for M. septentrionalis. We estimated SAR models using four environmental predictor variables measured at two landscape scales (0.5- and 2.4-km) representative of M. septentrionalis home range sizes in North America. The SAR models resulted in high predictive fit with withheld test observations and an independent data set of acoustic detections of M. septentrionalis from recent surveys (2016–2018), indicating a significant positive relationship existed between habitat quality (as an index of selection) and distribution of M. septentrionalis at landscape scales. At both spatial scales, M. septentrionalis showed positive selection of closed canopy interior forest, bottomland hardwood forest, and total perennial stream length, whereas at the 0.5-km scale, M. septentrionalis also showed a positive association with open canopy forest. Our models indicated that up to 7.0% and 8.5% of the state was comprised of potentially suitable forested summer habitats for M. septentrionalis for 0.5- and 2.4-km scales, respectively. Our models also indicated the distribution of highly selected habitats at landscape scales in Iowa and accurately predicted independent observations of M. septentrionalis in areas of the state where no capture efforts have occurred. This study provides methods to predict landscape-scale resource selection and distribution for bats where multiple fine-scale data sources exist across broad geographic regions.
Mapping the genicular arteries to provide a caution zone during knee surgery

Introduction Reports from the current literature show a lack of detail with depictions of the genicular arteries (GA). The intricate anatomy and infrequency of operating in the posterior knee may lead to surgeons being unfamiliar with the anatomy. The goal of this cadaveric study was to quantitatively map the arteries and create a caution zone that can be utilized when preparing and performing surgical procedures involving the knee. Materials and methods The left knees of 46 cadavers were used. The distance of the GAs were from the joint line (JL) (+, superior to JL; -, inferior to JL) was measured in two locations: popliteal artery (PA) branch point and medial/lateral knee. The angle the artery traveled between these two points in the posterior knee was measured. A caution map was created. Results The superolateral GA branched from PA at +47.3 mm and traveled superiorly at 57.7° to +52.2 mm at the lateral knee. The superomedial GA branched from PA at +55.2 mm and traveled superiorly at 66.8° to +57.3 mm at the medial knee. The inferolateral GA branched from PA at -0.6 mm. It traveled superiorly at 74.1° or inferiorly at 62.1° to -1.0 mm at the lateral knee. The inferomedial GA branched from the PA at +9.9 mm. It traveled inferiorly at 21.2° to -33 mm at the medial knee. Conclusion The GAs have a predictable pattern of location in the knee. There is a mismatch between medical textbooks and reality regarding arterial depictions. Knowledge regarding where the arteries are located may help reduce vascular complications in patients in the future.
Influence of Dynamic Interaction Between Multiple DFIGs on Low Frequency Oscillation of Power System

Large-scale grid integration of variable speed wind generators may pose a threat to the security of power system operation, one of which is the damping of power system low frequency oscillations. On the one hand, the newly integrated wind generators interact with the electromechanical oscillation circuit of the traditional synchronous generators. On the other hand, there are interactions between multiple wind generators, both of which will affect the low frequency oscillation of the power system. This paper develops the damping torque method to study the influence of the dynamic interaction between multiple DFIGs on the low frequency oscillation of the power system. Firstly, the state space model of the multi-machine power system is established, and the transfer function model of the DFIG is given. Then, the damping torque of the two DFIGs connected to the power system simultaneously is analyzed. The direct influence path and indirect influence path of the two DFIGs on the electromechanical oscillation circuit are given. Through decoupling, the influence of the dynamic interaction between the two DFIGs on the electromechanical oscillation mode of the power system can be quantitatively evaluated. Finally, the correctness of this method is demonstrated by an example. The research results of the paper provide the theoretical support for the optimal design and control of wind generators.