cssi/SciSciGPT-SciSciNet huggingface dataset:
Soft underlayer magnetization dynamics

A micromagnetic model for the writing process in perpendicular magnetic recording is developed to study the effect of the soft underlayer on the dynamic reversal of the recording layer. The upper part of the soft material is discretized micro-magnetically, each spin following LLG dynamics; the remaining part has infinite permeability. The validity of the model is tested in the static case. Dynamically, high-frequency spin motion is observed in the soft layer. Nevertheless, the field inside the data layer follows the time dependence of the input waveform.
STAT-3 activation is necessary for ischemic preconditioning in hypertrophied myocardium

The JAK-STAT pathway is activated in the early and late phases of ischemic preconditioning (IPC) in normal myocardium. The role of this pathway and the efficacy of IPC in hypertrophied hearts remai...
Sugar and Space? Not the Case: Effects of Low Blood Glucose on Slant Estimation are Mediated by Beliefs

There is a current debate concerning whether people's physiological or behavioral potential alters their perception of slanted surfaces. One way to directly test this is to physiologically change people's potential by lowering their blood sugar and comparing their estimates of slant to those with normal blood sugar. In the first investigation of this (Schnall, Zadra, & Proffitt, 2010), it was shown that people with low blood sugar gave higher estimates of slanted surfaces than people with normal blood sugar. The question that arises is whether these higher estimates are due to lower blood sugar, per se, or experimental demand created by other aspects of the experiment. Here evidence was collected from 120 observers showing that directly manipulating physiological potential, while controlling for experimental demand effects, does not alter the perception of slant. Indeed, when experimental demand went against behavioral potential, it produced judgmental biases opposite to those predicted by behavioral potential in the low blood sugar condition. It is suggested that low blood sugar only affects slant judgments by making participants more susceptible to judgmental biases.
Relationship of interleukin-6 with semen characteristics and oxidative stress in patients with varicocele.

Objectives. To examine levels of interleukin-6 (IL-6) in fertile semen donors and patients with varicocele and examine its association with semen characteristics and levels of reactive oxygen species (ROS). Methods. We conducted a prospective study consisting of 15 fertile donors (controls) and 35 infertile patients with varicocele. Semen analysis was performed according to the World Health Organization guidelines. IL-6 levels were measured using the enzyme-linked immunosorbent assay. ROS (10 4 counted photons per minute per 20 10 6 sperm) and total antioxidant capacity (molar trolox equivalents) were measured using a chemiluminescence assay. Results. The sperm concentration and motility were significantly greater in the donors compared with the infertile patients with varicocele (P 0.0001 and P 0.01, respectively). The IL-6 (log10 [IL-6 1]) and ROS (log10 [ROS 1]) levels were significantly greater in infertile patients with varicocele than in the donors (IL-6: 2.1 [1.7, 2.4] versus 0.7 [0, 1.9], P 0.003; ROS: 1.8 [1.2, 2.6] versus 1.0 [0.7, 1.6], P 0.04). The total antioxidant capacity levels were significantly lower in the varicocele patients (1166.7 366.2) than in the donors (1556.4 468.1; P 0.003). The IL-6 levels correlated significantly with the ROS levels in the infertile patients with varicocele (r 0.39; P 0.01). Conclusions. Infertile patients with varicocele exhibited elevated levels of IL-6 and ROS and decreased levels of total antioxidant capacity. Pro-inflammatory cytokine IL-6 and oxidative stress may play a role in the pathophysiology of infertility in these patients. UROLOGY 64: 1010‐1013, 2004. © 2004 Elsevier Inc.
The correlation between iron homeostasis and telomere maintenance

Eukaryotic organisms require iron to sustain genome stability, cell proliferation and development. Chromosomes contain telomeres to ensure complete replications and avoid fusions. Numerous evidences reveal that iron can act directly or indirectly on telomere maintenance. In human, disruption of systemic or cellular iron homeostasis is reportedly to cause serious health problems such as iron overload (hereditary hemochromatosis), iron deficiency anemia, carcinogenesis and acceleration of aging process. These processes commonly associate with abnormal telomere length. Additionally, cells containing mutations in iron-containing proteins such as DNA polymerases (Polα, δ, and ɛ), regulator of telomere length 1 (RTEL1) and the small subunit of ribonucleotide reductases (RNRs) have abnormal telomere length. This review briefly summarizes current understandings on iron homeostasis and telomere maintenance in cancer and aging process, followed by discussing their direct and indirect correlation, and the possible regulatory mechanisms.
Hydrogen Fluoride Gas Detection Mechanism on Quartz Using SAW Sensors

Hydrogen fluoride (HF) is a hazardous compound used in a variety of industrial processes and is a decomposition product of many environmentally harmful fluorinated volatile organic compounds. Surface acoustic wave (SAW) resonators on quartz substrates are suited for HF sensing because the analyte reacts directly with the sensor substrate, producing H2O and the volatile compound, SiF4. This work shows evidence that during gas phase HF exposure to a generalized SAW (GSAW) resonator and a pure shear horizontal SAW (SH-SAW) resonator, the dominant sensing mechanism is the detection of a condensed liquid layer on the substrate surface, rather than simply material removal via SiF4 desorption. The GSAW and pure SH-SAW resonators, fabricated on ST-X and ST-90° quartz, respectively, have been simultaneously exposed to HF in a low-volume (1.3 cm3) test cell. An automated gas delivery system developed under this project varied HF concentrations from 1-18 ppm. Both resonators are sensitive to the formation of a condensed liquid layer, but the frequency shift of the pure SH-SAW resonator, due to this effect, is up to 4.6 times greater than that of the GSAW device for the HF concentrations investigated. The measured sensor frequency response to potential inteferents, such as R-134a (C2H2F4), isopropanol (C3H8O), propane (C3H8), acetone (C3H6O), and carbon monoxide (CO), is below the device's limit of detection, while its response to HF is as high as 7.5 times its limit of detection.
Is International Relations Corrosive of International Law? A Reply to Martti Koskenniemi

Over the past two decades, cooperation between international law (IL) and international relations (IR) scholars has produced a vibrant, interdisciplinary IL/IR scholarship. Yet such interdisciplinarity has also produced a backlash from some legal scholars. Martti Koskenniemi, in particular, has for decades warned legal scholars about the potentially damaging effects of exposure to international relations. In his writings, Koskenniemi paints a picture of an IR field dominated by realism, in thrall to American policy-makers, and firmly committed to an antiformalism that is corrosive of international law and of the international legal profession, whose American practitioners have become so corrupted as to be unable to distinguish the law from the interests of American imperial power. Koskenniemi’s concerns, I argue, are not without foundation, yet his critique of IR represents at best an anachronism, and at worst a distortion of IR scholars’ attitudes, aims, and influence on the legal profession. IR scholarship is guilty of multiple sins, which can and should be corrected in dialogue with international legal scholars, but these sins are quite different from those imagined by Koskenniemi. The paper is organized in three parts. In the first, I briefly summarize Koskenniemi’s indictment of IR, including his provocative claim that IR has corrupted the American international law community. This argument, I argue, is flawed by a series of distortions of the views of IR and legal scholars alike, and does not survive careful scrutiny. In the second part of the paper, I take issue with Koskenniemi’s characterization of the IR field as a realist policy science, drawing on recent data to depict a field that is far more theoretically diverse and less in thrall to American policy-makers than Koskenniemi suggests. This is not to say, however, that IR scholarship is without fault as an approach to the study of international law. In the third and final section, therefore, I consider the real problems with IR scholarship in relation to international law. By contrast with Koskenniemi, who sees IR’s relentless antiformalism and commitment to interdisciplinarity as the field’s original sins, I argue that contemporary IR is characterized by precisely the opposite problems, namely a naive and unwitting formalism in its treatment of law, and a disciplinary insularity that has prevented IR scholars from learning some basic lessons that are familiar to international legal scholars. These weaknesses of IR scholarship are real, but they are remediable through more, not less, interdisciplinary collaboration.
New 5.8-GHz circularly polarized retrodirective rectenna arrays for wireless power transmission

This paper proposes two new circularly polarized retrodirective rectenna arrays, including a 2 /spl times/ 2 array and a 4 /spl times/ 4 array. A proximity-coupled microstrip ring antenna is used as the retrodirective rectenna array element, which can automatically block harmonic signals up to the third order from reradiating by the rectifying circuit. These arrays are printed on a Rogers Duroid 5880 substrate of /spl epsiv//sub r/=2.2 with a two-layer structure, with a total thickness of 1.5748 mm (or 62 mil). The new retrodirective rectenna array can track the incoming power source signals automatically and is less sensitive to the power incident angle variations, i.e., main-beam alignment deviation. It can provide a nearly constant dc output voltage within /spl plusmn/10/spl deg/ and 90% dc output voltage within /spl plusmn/45/spl deg/. The conversion efficiencies of the two arrays are 73.3% and 55%, respectively, when the power density is 10 mW/cm/sup 2/. The retrodirective rectenna array can be used in the low-power density applications for microwave wireless power transmissions.
The design and analysis of non-uniform down-sized differential distributed amplifiers

In this paper, the design and analysis of a novel non-uniform fully differential distributed amplifier is presented. The gain-bandwidth product of the proposed amplifier designed in a 0.18 /spl mu/m standard CMOS process reaches a record level of 34.76 GHz. Proved by both the analytical models and the HSPICE simulations, down-sizing the device and inductor sizes of each stage with respect to the preceding stage in a distributed amplifier results in a better gain-bandwidth product. A comprehensive analytical study is carried out to predict the behavior of the amplifier. HSPICE simulations verify the superior performance of the proposed non-uniform distributed amplifier compared to its conventional counterpart in terms of a better gain-bandwidth product and a flat frequency response.
Effects of Voluntary Control of Blood Pressure on Cardiovascular Regulation During Postural Change

This research is part of a larger program on the behavioral and psychological regulation of cardiovascular adjustments to postural change. The long-range objective is to develop methods for the behavioral management of patients with orthostatic hypotension. This paper describes methods developed for the continuous non-invasive tracking of systolic and diastolic blood pressure as well as heart rate during postural change — going from a sitting to a standing position, and the use of these methods in two studies of young, healthy, normotensive individuals. This first study shows the methods to be sensitive to blood pressure and heart rate differences in postural regulation as a function of family history of hypertension. The second shows that cardiovascular adjustments to postural change can be modified by voluntary control and biofeedback procedures. The research supports the role of the central nervous system in the regulation of basic circulatory reflexes.
Ergodic capacity in mmWave ad hoc network with imperfect beam alignment

Millimeter wave (mmWave) technology has several technical hurdles to overcome before becoming an integral next-generation wireless technology. One such hurdle is the alignment of the steerable mmWave antenna array. This paper quantifies both the ergodic capacity of a mmWave ad hoc network with perfect alignment and the loss in ergodic capacity when error is introduced. First, we leverage stochastic geometry to evaluate the ergodic capacity (bits/sec/Hz/area) in the network. Next, we compare two antenna models that are commonly used: sectored and Gaussian. Lastly, we derive expressions that quantify the loss in ergodic capacity per user when alignment error occurs at the receiver and transmitter. Our results show that even relatively small errors in alignment can lead to significant ergodic capacity reduction.
Adhesion and Autohesion of Rubber Compounds: Effect of Surface Roughness

Abstract Sheets of various rubber compounds were pre-molded using different mold surfaces: Mylar film, smooth steel, and roughened steel. Two sheets of the same compound were then bonded together by crosslinking them in contact. Measurements of peel strength were carried out over a range of temperatures from −40°C to + 130°C. When an uncured sheet was crosslinked in contact with a smooth fully-cured sheet, the peel strength was generally lower than the tear strength of either sheet and the degree of interlinking was inferred to be only about one-half of the degree of crosslinking. On the other hand, when a sheet was cured in contact with a rough surface the strength of adhesion was 2× to 3× higher than with a smooth surface, probably because of increased area for bonding. Thus, when a rubber compound was cured in contact with a fully-cured sheet having a roughened surface, the two effects largely cancelled out and the resultant bond was about as strong as the material itself. Examples are given for carbon...
Paediatric sedation for imaging is safe and effective in a district general hospital.

Objective:To devise a safe and effective sedation protocol for imaging paediatric patients in a small district general hospital (DGH).Methods:Chloral hydrate, alimemazine and learned best practice were used for imaging 105 children between January 2013 and May 2015. We retrospectively reviewed case notes for this time period to establish rates of successful sedation and adverse events.Results:Scanning was successful in 100/105 (95%) children. No serious adverse events were reported. Non-serious adverse events occurred in eight cases. 12 patients were discharged more than 4 h after scanning owing to prolonged sedation.Conclusion:This is a safe and effective protocol for delivering sedation for imaging in paediatric patients. We would encourage similar centres to adopt this protocol where resources for i.v. sedation and general anaesthesia are limited.Advances in knowledge:There are many different sedation protocols in the literature for imaging in paediatric patients, with varying levels of success and adv...
Ingestion and Elimination of Cesium-134 by the Spider, Pardosa lapidicina

Ingestion, assimilation, and elimination rates of Pardosa lapidicina Emerton were determined in the laboratory using a radioactive tracer. Radioactivity was lost in a pattern termed a single component retention curve. We observed complete assimilation and a slow turnover rate for 134Cs. More differences than similarities were found when results for this spider were compared with those for other lycosid species. Possible adaptions to explain the generally low elimination coefficients observed in this species are discussed.
Stimulation of DNA synthesis in rat kidney by repeated administration of lead.

SummaryEffects of repeated administration of lead on DNA synthesis in rat kidneys were investigated by autoradiographic methods. In the epithelium of proximal and distal tubules, three injections of lead (0.05 mg lead/g body wt), given at 2-day intervals, excited successive waves of cellular DNA synthesis, 20-40 times above the normal level. The peak of the initial wave of DNA synthesis occurred 30 hr after the first dose of lead, whereas the peaks of the second and third waves appeared 6 hr after the second and third doses of lead, respectively. After each wave of 3H-thymidine uptake, labeling activity declined to a level that remained approximately 6 times that in control rats.
LI Transport and the Psychoses

Previous studies have suggested that intracellular to extracellular concentrations of Li across RBC membranes (Li ratios) may be useful in identifying Li responsive affective illnesses. Though agreement is not unanimous, several authors have reported that higher Li ratios obtained in RBC exposed to Li in vitro or in vivo are associated with short term antimanic or antidepressant effects of Li, or with successful prophylaxis from affective episodes.Higher Li ratios, when determined by direct measurements of RBC as well as plasma Li,6-10 as well as impaired countertransport of Li from the RBC,11 appear to occur with a high frequency among affectively disordered patients who experience both manic and depressive episodes (bipolar disorder).
Correlating the Sonographic Finding of Echogenic Debris in the Bladder Lumen With Urinalysis

Objectives The purpose of this study was to determine the significance of urinary bladder debris detected by sonography. Methods We conducted a retrospective analysis of urinalysis results in age-matched patients with and without bladder debris detected by transabdominal sonography. Patients were recruited from a radiology database search for bladder sonograms either with words suggesting echogenic debris or by a clinical history suggesting an infectious course. The sonograms were randomized and read by a single radiologist, who was blinded to case versus control. The urinalysis and sonographic results were analyzed by the Fisher exact test. Results There was no statistically significant correlation between the finding of debris on sonography and the frequency of abnormal urinalysis results, regardless of the quality of debris (layering versus floating). The only variable that was significantly associated with abnormal urinalysis results was a clinical history suggesting infection. Conclusions A urinalysis should not be routinely recommended to work up the finding of urinary bladder debris on sonography.
A national survey of percutaneous central venous catheter practices in neonates.

PURPOSE This study was conducted to describe current practices for maintenance of percutaneous central venous catheters (PCVCs). DESIGN A survey technique was used. SAMPLE A national mailing to 511 nurseries resulted in a response from 309. Of those who responded, 206 reported using PCVCs. MAIN OUTCOME VARIABLE Maintenance practices for PCVCs. RESULTS The most common catheter site preparation technique was the use of Betadine, or Betadine and alcohol. Transparent dressings were the most commonly used site cover, and were changed when loose or soiled. Contamination precautions varied; most nurseries used Y-administration sets and extension tubing for medication administration into the PCVC system.
Electroventilation: A missed opportunity?

"Electroventilation" identifies the many techniques used to produce artificial respiration by the application of trains of stimuli to strategically placed body-surface electrodes. The author reviews the efficacy and safety of electroventilation and traces its history and present status. The theoretical and practical bases for the method are presented, along with numerous examples of its use in man and animals. The article concludes with the indications and contraindications for electroventilation.
Discrepancies in Autonomy and Relatedness Promoting Behaviors of Substance Using Mothers and Their Children: The Effects of a Family Systems Intervention.

Parents’ and children’s autonomy and relatedness behaviors are associated with a wide range of child outcomes. Yet, little is known about how parents and children’s autonomy and relatedness behaviors jointly influence child outcomes. The current study captured this joint influence by exploring the longitudinal trajectory of mother–child discrepancies in autonomy and relatedness behaviors and its association with child problem behaviors. The effects of a family systems intervention on the trajectory of mother–child discrepancies were also examined. The sample included 183 substance using mothers and their children (M age = 11.54 years, SD = 2.55, range 8–16; 48 % females). Both the mother and child completed an assessment at baseline, 6- and 18-month post-baseline. A person-centered analysis identified subgroups varying in mother–child discrepancy patterns in their autonomy and relatedness behaviors. The results also showed that participation in the family systems therapy was associated with decreased mother–child discrepancies, and also a synchronous increase in mother’s and child’s autonomy and relatedness. Additionally, increased mother–child discrepancies and mother–child dyads showing no change in autonomy and relatedness was associated with higher levels of children’s problem behaviors. The findings reveal a dynamic process of mother–child discrepancies in autonomy and relatedness behaviors related to child outcomes. The findings also support the effectiveness of the family systems therapy, and highlight the importance of understanding the complexities in family interactions when explaining children’s problem behaviors.
Grandparents providing care for grandchildren: implications for economic preparation for later life in South Korea

Mounting concern about economic preparation for later life combined with a growing number of grandparents providing grandchild care is fuelling increased interest in these topics in Korea. However, few studies have evaluated the relationship between providing care to grandchildren and economic behaviour. Guided by intergenerational exchange theory, this paper analyses the relationships between providing grandchild care and monetary compensation for care, and economic preparation for later life. Data come from a sub-sample of 2,599 grandmothers in the Korean Retirement and Income Study who have a grandchild under the age of ten, 279 of whom report providing regular care to grandchildren. Controlling for age, education, marital status and household income, the average amount of grandchild care provided per week is a significant negative predictor of economic preparation for later life among grandmothers. However, receiving financial compensation for providing grandchild care is not significantly related to economic preparation and did not mediate or moderate the relationship between amount of care provided and economic preparation. The implications of these findings and limitations of this study are also discussed.
Navigating Media Use: Chinese Parents and Their Overseas Adolescent Children on WeChat

In many Chinese families, adolescent children are moving abroad to pursue higher education. Due to cultural issues and China's One-Child Policy, parents have high expectations for their children and are willing to invest time and money to help them build a successful future. In this study, we interviewed 9 Chinese students in undergraduate or graduate programs in the US and 15 Chinese parents in China whose children are studying abroad about their family communications. Parents and students used a variety of media, and families negotiated how each medium was used. Most families eventually migrated to communicate through WeChat, the ubiquitous Chinese based cross-platform instant messaging service. The negotiation of what medium to use, how to use and when to use specific media was tied the students' and parents' goals to construct a positive presentation of self. Based upon these findings we offer design considerations for cross-cultural, family and intimate long-distance communication media.
Biological Self-Assembled Porous Ceramics as High Temperature Insulation in Steam Transport Pipes

Biological self-assembled porous ceramics could serve as a substitute for asbestos in thermally insulating applications, such as steam transport pipes in coal- fi red power plants. To become a viable alternative to asbestos, a biologically self-assembling ce­ ramic would have good thermal stability up to 650°C, have low thermal conductivity, and be nontoxic and light weight. Ball clay was chosen as the base for the ceramic. By adjusting the amounts of water, yeast, salt, and sugar in the slurry, the sample with the lowest density was found, as it would be most likely to yield the highest porosity, and thus lowest thermal conductivity.
Alcohol-Use Disorder and Severe Mental Illness

Alcohol-use disorders (AUD's) commonly occur in people with other severe mental illnesses, such as schizophrenia or bipolar disorder, and can exacerbate their psychiatric, medical, and family problems. Therefore, to improve detection of alcohol-related problems, establish correct AUD diagnoses, and develop appropriate treatment plans, it is important to thoroughly assess severely mentally ill patients for alcohol and other drug abuse. Several recent studies have indicated that integrated treatment approaches that combine AUD and mental health interventions in comprehensive, long-term, and stagewise programs may be most effective for these clients.
Serpoleskea minutissima comb. nov., a micro-rheophyte in the Pylaisiadelphaceae

A recent collection of Platydictya minutissima from Kentucky, U.S.A., prompted a re-examination of the species. Based on rhizoid placement and pseudoparaphyllium form, the taxon is transferred to Serpoleskea as S. minutissima (Sull. & Lesq.) W.R.Buck & B.H.Allen. The species is restricted to eastern North America. Ecologically the taxon grows on moist rocks in or along streams, becoming submerged at times of high water.
Improved Outcomes in Men with Advanced Prostate Cancer.

The impressive and positive clinical trial results that are described by Fizazi et al.1 and James et al.2 in this issue of the Journal represent an important advance in androgen-signaling inhibition for metastatic prostate cancer. The LATITUDE and STAMPEDE research teams report encouraging improvements in the initial treatment of men with advanced prostate cancer. Metastatic, castration-sensitive prostate cancer is diagnosed in a small proportion of men with prostate cancer at initial presentation and is disproportionately represented in lethal prostate cancer. The findings of these two trials suggest that therapeutically relevant biologic features of this form of cancer are shared with . . .
Land Use Pattern and Cropping Pattern Followed by Co-operative Credit Borrowers

An empirical study was carried out with an objective to study the land utilization pattern and cropping pattern followed by the cooperative credit borrowers of District Central Co-operative Bank (DCCB) of Parbhani district. In analytical techniques and tabular analysis were carried out which included mean, percentage, frequency and ratio. It was revealed from the study that at overall average level, the total land holding of borrowers under marginal, small, medium and large farmers were 0.84, 1.67, 2.79 and 5.56 ha. for category I, 0.79, 1.71, 2.74 and 5.70 ha. for category II and 0.80, 1.69, 2.77 and 5.61 ha. for category III, respectively. In case of cropping pattern, it was also revealed that in category I, at overall average level wheat occupied the highest area (17.01 %) of the gross cropped area followed by soybean (15.98 %), cotton (13.93 %) and groundnut (12.50 %). On the contrary, in category II and III, soybean occupied highest area followed by wheat, cotton and groundnut.
A Covariate Model for Partially Censored Data Subject to Competing Causes of Failure

UNTIL recently, statistical models for competing risks data have been used mostly in reliability, actuarial and demography settings. They are now finding increased use in the analysis of medical data. For example, a cancer clinical trial may have as its main endpoint the time of disease recurrence as well as the mode (e.g. local versus metastatic) of recurrence in a population of patients. Since these studies typically involve heterogeneous patient populations, another concern is the assessment of baseline variables and their relationship to outcome. In particular, one would want to determine if covariates such as age, sex, etc. had any influence on type of failure, time until failure, or possibly both. Covariate methods have been examined quite extensively in the context of survival (i.e. single risk) studies (see, for example, Feigl and Zelen, 1965; Zippin and Armitage, 1966; Glasser, 1967; Cox, 1972; Prentice, 1973; Peto and Lee, 1973; Breslow, 1974). However, with the exception of the paper by Holt (1978), there do not seem to be any published accounts of covariate models for competing risks data. This paper presents an exponential competing risks model which incorporates covariate variables and right censored observations. From one point of view it represents the natural extension of the Glasser survival model to a censored competing risk setting. It can also be viewed as an extension of the exponential competing risk problem (Chiang, 1968) to include covariates. Also, the probability model used here is a special case of one considered by Holt (1978) but, as will be discussed later, the method of inference employed by the latter is based on partial likelihoods whereas the full likelihood function is utilized in this paper. Section 2 introduces the basic model and its extension to include covariates. Section 3 brings in the notion of censored observations and presents methods for analysis as well as model testing. The techniques are illustrated in Section 4 with the results of a current lung cancer clinical trial. Finally, Section 5 compares our approach to that of Holt (1978).
Strain partitioning in Southeastern Alaska: Is the Chatham Strait Fault active?

Abstract A 1200 km-long transform plate boundary passes through southeastern Alaska and northwestern British Columbia and represents one of the most seismically active, but poorly understood continental margins of North America. Although most of the plate motion is accommodated by the right-lateral Queen Charlotte–Fairweather Fault (QCFF) System, which has produced at least six M > 7 earthquakes since 1920, seismic hazard assessments also include the Chatham Strait Fault (CSF) as a potentially active, 400 km-long strike slip fault that cuts northward through southeastern Alaska, connecting with the Eastern Denali Fault. Nearly the entire length of the CSF is submerged beneath Chatham Strait and Lynn Canal and has never been systematically imaged using high-resolution marine geophysical approaches. In this study we present an integrated analysis of new marine seismic reflection data acquired across Lynn Canal and tectonic block modeling constrained by data from continuous and campaign GPS sites. Seismic profiles cross the CSF at twelve locations spanning ∼50 km of fault length; they reveal thick (up to 300 m) packages of glaciomarine sedimentary facies emplaced on an unconformity surface that formed during the Last Glacial Maximum (LGM). Localized warping of post-LGM stratigraphy (∼13.9 kyr B.P. to present) appears to correlate with sediment drape on basement topography and current-controlled deposition. There is no evidence for an active fault along the axis of Lynn Canal in the seismic reflection data. Crustal block models constrained by GPS data allow, but do not require, a maximum slip rate of 2–3 mm/yr along the CSF; higher slip rates on the CSF result in significant misfit to GPS data in the surrounding region. Based on the combined marine geophysical and GPS observations, it is plausible that the CSF has not generated resolvable coseismic deformation in the last ∼13 ka and that the modern slip-rate is
Prevalence and Factors Associated With Gluten Sensitivity in Inflammatory Bowel Disease

AbstractObjectives: Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease (IBD) are unclear. This study evaluated the prevalence of GS and factors associated with GS in IBD.Methods: Adult IBD patients at a tertiary-care medical center completed a survey of their demographics, medical history, family history, social history and symptoms. Data on IBD characteristics were abstracted from the medical records. Descriptive analyses estimated the prevalence of GS. Multivariable logistic regression assessed the association between GS and patient or disease factors.Results: Of 102 IBD patients (55 Crohn’s disease [CD], 46 ulcerative colitis [UC] and 3 IBD-unclassified), GS was reported in 23.6 and 27.3% of CD and UC patients, respectively. Common symptoms included fatigue, abdominal pain, diarrhea, bloating and hematochezia. There was no difference in these symptoms when comparing patients with and without GS. ...
The Epidemiology of Imported Acute Infectious Diseases in Zhejiang Province, China, 2011–2016: Analysis of Surveillance Data

To explore epidemiological characteristics of imported acute infectious diseases between 2011 and 2016 in Zhejiang province, China. Data of imported infectious diseases from 2011 to 2016 was collected from the China Information System for Disease Control and Prevention in Zhejiang province, and subsequently analyzed for epidemiological characteristics. A survey was conducted to investigate clinicians' abilities to diagnose these diseases in Zhejiang province. From 2011 to 2016, 1,241 cases of imported acute infectious disease were reported in Zhejiang province, including 1,078 malaria cases, 156 dengue cases, three chikungunya fever cases and four Zika cases. Between 2011 and 2016, incidences of these diseases increased (P < 0.001). For malaria, male adults for labor export were the most affected group. Seasonal fluctuation was not obvious. Plasmodium falciparum was the main malaria type (822 cases) and most cases were acquired from African Region (791/822, 96.1%). Plasmodium vivax cases (194 cases) were mainly from African Region (78/194, 40.2%) and South-East Asia Region (51/194, 26.3%). Meanwhile, for dengue, adults and tourists were the most affected groups. The incidence of dengue was particularly high in August and October. The percent of correct clinician responses in the survey of diagnosis knowledge was 54.6% (standard deviation = 21.0%); this percentage was particularly low in general practitioners and clinicians from township hospitals. The capabilities of clinicians to diagnose these diseases were low and should be improved. Efforts should be made in improving and disseminating proper preventive measures of high-risk populations, surveillance of imported cases, and prevention and control of local epidemics.
End-to-end text-independent speaker verification with flexibility in utterance duration

We continue to investigate end-to-end text-independent speaker verification by incorporating the variability from different utterance durations. Our previous study [1] showed a competitive performance with a triplet loss based end-to-end text-independent speaker verification system. To normalize the duration variability, we provided fixed length inputs to the network by a simple cropping or padding operation. Those operations do not seem ideal, particularly for long duration where some amount of information is discarded, while an i-vector system typically has improved accuracy with an increase in input duration. In this study, we propose to replace the final max/average pooling layer with a Spatial Pyramid Pooling layer in the Inception-Resnet-v1 architecture, which allows us to relax the fixed-length input constraint and train the entire network with the arbitrary size of input in an end-to-end fashion. In this way, the modified network can map variable length utterances into fixed length embeddings. Experiments shows that the new end-to-end system with variable size input relatively reduces EER by 8.4% over the end-to-end system with fixed-length input, and 24.0% over the i-vector/PLDA baseline system. an end-to-end system with.
INSEMINAÇÃO ARTIFICIAL A FRESCO EM UMA FÊMEA BULLDOG INGLÊS: RELATO DE CASO

Este relato de caso teve como objetivo descrever uma tecnica de inseminacao artificial modificada, em uma femea Bulldog Ingles, utilizando e metodo de inseminacao artificial vaginal a fresco . Apos deteccao do cio, por citologia vaginal, com celulas superficiais acima de 80%, utilizou-se cerca de 5ml de semen a fresco , colhido por metodo de estimulacao manual, com uma seringa esteril de 10ml. Os membros pelvicos da femea foram elevados dorsalmente e atraves de uma pipeta comercial, o semen foi introduzido na regiao do vestibulo vaginal. A tecnica foi repetida tres vezes e decorrido 27 dias do inicio do protocolo, detectou-se por exame ultrassonografico a imagem sugestiva de cinco fetos viaveis. Concluiu-se que a tecnica descrita utilizando semen a fresco e de facil aplicabilidade e alta viabilidade
Point/Counterpoint on the Miranda Decision: Should It Be Replaced or Retained?

In this point/counterpoint exchange, Professors Paul Cassell and Amos Guiora debate the U.S. Supreme Court’s decision in Miranda v. Arizona. Cassell challenges the decision, arguing that it has had harmful effects on American law enforcement efforts. Cassell cites evidence that the decision led to reduction in crime clearance rates and urges that the restrictions in the decision be replaced by a requirement that the police videotape interrogations. Cassell urges prosecutors to consider arguing that modern tools like videotaping creates a legal regime that allows the technical Miranda rules to be regarded as superseded relics of an outmoded and harmful prophylactic regime. Guiora responds that the Miranda decision was required to protect vulnerable suspects during inherently coercive police interrogation. Guiora reviews the language Chief Justice Warren used in the Miranda decision, noting that Warren was concerned to ensure that a suspect’s basic constitutional rights were respected by law enforcement while conducting custodial interrogation. Guiora concludes that the decision remains as important today as it was when handed down in 1966.
Accuracy of diagnosing mantle cell lymphoma and identifying its variants on fine-needle aspiration biopsy.

Background Mantle cell lymphoma (MCL) is an incurable B-cell lymphoma portending an aggressive clinical course; the blastoid and pleomorphic morphological variants have an even worse prognosis. In addition, patients with classic morphology and a high proliferation index (HPI), also have reduced survival. Although variants have been defined, to the authors' knowledge the ability to detect these subtypes by fine-needle aspiration biopsy (FNAB) has not been described. Methods MCL cases diagnosed by lymph node FNAB with concurrent core needle biopsy were reviewed from 146 patients, accounting for 172 specimen pairs. FNAB and core needle biopsy diagnoses were compared to determine concordance rates. Flow cytometric immunophenotype and Ki-67 rates were evaluated. Results The classic subtype was diagnosed in 58% of cases (99 of 172 pairs) and variant morphology was diagnosed in 42% of cases (73 of 172 pairs) by histology. Twenty-nine patients presented with variant morphology whereas 28 underwent transformation. A nontraditional immunophenotype including loss of CD5 or FMC-7 and expression of CD23 and CD10 was found in 44% of variants (29 of 66 variants) and 19% of classic subtypes (18 of 94 classic subtypes) (P = .0008). Ki-67 rates averaged from 56% to 76% for blastoid and pleomorphic cases, 53% to 55% for MCL-HPI cases, and 17% to 19% for classic cases. The sensitivity and specificity to detect MCL variants by FNAB were 74% and 93%, respectively. Conclusions The accuracy of diagnosing MCL is high when adequate samples for cytomorphology and flow cytometry are obtained. Subtyping variants by cytomorphology alone has challenges, but overall demonstrates high sensitivity and specificity. The performance of Ki-67 on cytology specimens is useful for detecting MCL with HPI.
A Paleocoastal Site Complex from Santarosae Island, California

Four recently identified sites from eastern Santa Rosa Island contain flaked-stone artifacts diagnostic of Paleocoastal occupations between ∼13,000 and 8000 calendar years ago. The largest site (CA...
Racial dynamics underlying crime commission, emotionality, and last statements among executed offenders in Texas

AbstractWe consider here whether African-Americans executed on death row in Texas are consequently (a) more likely to have committed economically-motivated secondary crimes during the commission of...
Epidemiology and Public Health Implications of the Opioid Crisis

Opioid overdose deaths continue to grow nationwide. Simultaneously, efforts to understand and promote the appropriate management of substance use and pain are expanding. The goals of improved treatment for patients and responding to the opioid overdose epidemic are both priorities. Pediatric and adult care providers must reconsider their approach to pain and substance use disorder in light of the current opioid epidemic. This chapter summarizes general principles about opioid use disorder, presents an overview of the epidemiology and public health implications of the contemporary opioid crisis, and closes with an overview of current approaches to prevention, treatment, and harm reduction.
Clinical outcomes with early-elective discontinuation of PD-1 inhibitors (PDi) at one year in patients (pts) with metastatic melanoma (MM).

10048Background: Randomized trials of PDi in MM permitted treatment for 2 years (pembrolizumab) or more (nivolumab). However, the optimal treatment duration is unknown, and shorter courses may be e...
P27 Contextual Factors Influence Childcare Providers’ Barriers for Serving Healthy Meals to Preschool Children.

Background The Child and Adult Care Food Program (CACFP) and other national policies recommend serving healthy foods and beverages in childcare settings to promote healthy eating behaviors and prevent childhood obesity. However, childcare providers have reported several barriers to serving healthy foods and beverages to the children. To address the barriers, more evidence is needed regarding the contextual factors associated with the childcare providers’ tendency to report specific barriers. Objectives To examine contextual factors (geographic location, participation in CACFP, type of childcare program, mealtime practices, and personnel responsible for menu planning) that are related to childcare providers’ perceived barriers to serving healthy foods and beverages to preschool (2 to 5-year-old) children. Study Design, Setting, Participants Cross-sectional study with a self-reported survey completed by childcare center (CCC) directors (n = 336) and family childcare home (FCCH) providers (n = 1154) from licensed childcare settings (n = 1490) across urban and rural Nebraska. Analysis Descriptive statistics and multiple logistic regression analyses. Results Rural childcare providers were more likely to report not having enough money to purchase healthy foods and limited storage space as barriers as compared to their urban counterparts. CACFP-funded settings reported not having enough money, not knowing which recommendation to follow, unsure which foods can be reimbursed through CACFP, and lack of availability of healthy foods as compared to the non-CACFP settings. Participants reporting lower frequency of professional development on nutrition were more likely to report barriers of not having enough money and not knowing which recommendation to follow. Barrier regarding lack of availability of healthy foods was associated with providers’ residing in food deserts, receiving less professional development and being CACFP-participants. Lack of time was reported as a barrier when FCCH providers and CCC owners or directors were responsible for menu planning. Conclusions Considering contextual factors influencing providers’ barriers can improve healthy food availability in childcare.
Photonic Assisted Microwave Near-Field Imager

The first nanophotonic near-field imager is reported that optically processes the received microwave signals to form a 121-pixel image. It achieves 4.8° spatial resolution and is significantly smaller and more power efficient than the all-electrical counterparts.
Privacy and Competing Library Goals: How Can Library Directors Lead When Values Collide?

Privacy is easy for librarians to appreciate until the discovery that other library interests — like information access; personalization of services; new services; security of people, places and data; and even variations on privacy itself — can compete with privacy. During the late 20th century, librarians and United States’ culture embraced the idea of reader privacy and particularly privacy of library use, but the 21st century has introduced many new privacy challenges. Librarians now face novel privacy implications as we consider how to make the most of new technologies and practices such as digitization of special collections, data mining of our collection use patterns, and any number of social approaches to scholarly communications. We also have an abundance of new privacy challenges relating to user information and digitized materials containing personal information, as well as a number of privacy obligations not unique to libraries such as website privacy policies, data security, and employee privacy. The tradeoffs required to protect library-related privacy are becoming more costly, and the choices are increasingly complicated by an evolving set of federal and state privacy laws and shifting policy norms which librarians must master and even help to shape.This chapter is offered as support for librarians who must lead libraries through this fraught territory where privacy and other values collide. Privacy choices involve law, policy, and practical concerns, and each of these three considerations is subject to change due largely to rapidly developing technologies and perhaps slightly less rapidly evolving cultural norms. Librarians and especially academic law library directors are charged with taking a long view of managing a library’s collection and services, so this chapter provides a broad overview of the complex areas of related privacy law and policy to provide some guidance with more lasting utility than an examination of the many specific privacy-related challenges facing libraries at the time of this writing. The chapter begins with a brief history and current context for libraries and privacy and then identifies some approaches to addressing privacy, drawing on a sample of issues relating to privacy of library users, of individuals represented in library collections, and of library employees.
Real projective connections, V. I. Smirnov’s approach, and black-hole-type solutions of the Liouville equation

We consider real projective connections on Riemann surfaces and their corresponding solutions of the Liouville equation. We show that these solutions have singularities of a special type (a black-hole type) on a finite number of simple analytic contours. We analyze the case of the Riemann sphere with four real punctures, considered in V. I. Smirnov’s thesis (Petrograd, 1918) in detail.
Dual Regularized Optimal Transport.

In this paper, we present a new formulation of unbalanced optimal transport called Dual Regularized Optimal Transport (DROT). We argue that regularizing the dual formulation of optimal transport results in a version of unbalanced optimal transport that leads to sparse solutions and that gives us control over mass creation and destruction. We build intuition behind such control and present theoretical properties of the solutions to DROT. We demonstrate that due to recent advances in optimization techniques, we can feasibly solve such a formulation at large scales and present extensive experimental evidence for this formulation and its solution.