cssi/SciSciGPT-SciSciNet huggingface dataset:
Short-term building energy model recommendation system: A meta-learning approach

Abstract High-fidelity and computationally efficient energy forecasting models for building systems are needed to ensure optimal automatic operation, reduce energy consumption, and improve the building’s resilience capability to power disturbances. Various models have been developed to forecast building energy consumption. However, given buildings have different characteristics and operating conditions, model performance varies. Existing research has mainly taken a trial-and-error approach by developing multiple models and identifying the best performer for a specific building, or presumed one universal model form which is applied on different building cases. To the best of our knowledge, there does not exist a generalized system framework which can recommend appropriate models to forecast the building energy profiles based on building characteristics. To bridge this research gap, we propose a meta-learning based framework, termed Building Energy Model Recommendation System (BEMR). Based on the building’s physical features as well as statistical and time series meta-features extracted from the operational data and energy consumption data, BEMR is able to identify the most appropriate load forecasting model for each unique building. Three sets of experiments on 48 test buildings and one real building were conducted. The first experiment was to test the accuracy of BEMR when the training data and testing data cover the same condition. BEMR correctly identified the best model on 90% of the buildings. The second experiment was to test the robustness of the BEMR when the testing data is only partially covered by the training data. BEMR correctly identified the best model on 83% of the buildings. The third experiment uses a real building case to validate the proposed framework and the result shows promising applicability and extensibility. The experimental results show that BEMR is capable of adapting to a wide variety of building types ranging from a restaurant to a large office, and gives excellent performance in terms of both modeling accuracy and computational efficiency.
The focal segmental glomerulosclerosis permeability factor: biochemical characteristics and biological effects.

Focal segmental glomerulosclerosis (FSGS) is characterized by steroid resistant nephrotic syndrome and progression to end-stage renal disease. Proteinuria in certain patients with FSGS may be cause...
Research on Variable Structure Sliding Mode Control System of Brushless Direct Current Motor

The basic theory of variable structure sliding mode control (VSSMC) is discussed.The model of VSSMC of Brushless DC motor is designed and verified by emulation,and directed to the form of state equation.The line of variable structure sliding mode is selected according to proportional control run to zero with fixed speed.The exsisting conditions of variable structure sliding mode are given.The design is used in a BLDCM timing system.The simulation and experiment is finished.Compare with the traditional PI control,the VSS is proved that the system performance is improved.
Model systems for aging research: syncretic concepts and diversity of mechanisms.

A variety of very different phenomena have been subsumed under the heading of "aging" research. A review of recent experimental data, in several of the best-studied model systems for the investigation of aging, indicates that molecular changes which are putative or demonstrated proximal causes of senescent deterioration are generally not shared by other systems examined. It is thus argued that different aberrant biochemical processes have evolved as the "weakest link" limiting longevity or intermeiotic interval in different systems, although in each case the germ line must be exempted.Key words: aging, senescence, meiosis, DNA, RNA.
MO-FG-209-03: Simulation of Breast Anatomy at the Cellular Scale

This symposium will review recent advances in the simulation methods for evaluation of novel breast imaging systems – the subject of AAPM Task Group TG234. Our focus will be on the various approaches to development and validation of software anthropomorphic phantoms and their use in the statistical assessment of novel imaging systems using such phantoms along with computational models for the x-ray image formation process. Due to the dynamic development and complex design of modern medical imaging systems, the simulation of anatomical structures, image acquisition modalities, and the image perception and analysis offers substantial benefits of reduced cost, duration, and radiation exposure, as well as the known ground-truth and wide variability in simulated anatomies. For these reasons, Virtual Clinical Trials (VCTs) have been increasingly accepted as a viable tool for preclinical assessment of x-ray and other breast imaging methods. Activities of TG234 have encompassed the optimization of protocols for simulation studies, including phantom specifications, the simulated data representation, models of the imaging process, and statistical assessment of simulated images. The symposium will discuss the state-of-the-science of VCTs for novel breast imaging systems, emphasizing recent developments and future directions. Presentations will discuss virtual phantoms for intermodality breast imaging performance comparisons, extension of the breast anatomy simulation to the cellular level, optimized integration of the simulated imaging chain, and the novel directions in the observer models design. Learning Objectives: 1.Review novel results in developing and applying virtual phantoms for inter-modality breast imaging performance comparisons; 2.Discuss the efforts to extend the computer simulation of breast anatomy and pathology to the cellular level; 3.Summarize the state of the science in optimized integration of modules in the simulated imaging chain; 4.Compare novel directions in the design of observer models for task based validation of imaging systems. PB: Research funding support from the NIH, NSF, and Komen for the Cure; NIH funded collaboration with Barco, Inc. and Hologic, Inc.; Consultant to Delaware State Univ. and NCCPM, UK. AA: Employed at Barco Healthcare.; P. Bakic, NIH: (NIGMS P20 #GM103446, NCI R01 #CA154444); M. Das, NIH Research grants
Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling

Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes severe kyphosis and a growth defect with decreased chondrocyte proliferation, accelerated hypertrophic differentiation and cell death with reduced Hif1a expression. Eed deficiency also causes induction of multiple signalling pathways in chondrocytes. Wnt signalling overactivation is responsible for the accelerated hypertrophic differentiation and kyphosis, whereas the overactivation of TGF-β signalling is responsible for the reduced proliferation and growth defect. Thus, our study demonstrates that PRC2 has an important regulatory role in lineage-committed tissue cells by suppressing overactivation of multiple signalling pathways.
Horseradish Peroxidase Compound II Heme-Linked Ionization Monitored by the Resonance Raman Fe(IV) = 0 Stretching Vibration

Peroxidases are members of a class of heme proteins which undergo oxidations of the heme to states above iron (III) in the intermediate enzymatic states. Upon reaction with peroxides, the brown resting enzyme, which contains an Fe (III) heme, is converted to a green intermediate known as compound I, which is two oxidation equivalents above the resting enzyme. A one electron reduction of compound I produces a red intermediate known as compound II. Compound II is believed to contain an Fe(IV) porphyrin 7r-radical cation. Compound II is an Fe(IV) heme.
CDMA communication system performance for a constellation of CubeSats around the Moon

In this paper a communication system for CubeSats in formation that operate in the vicinity of the Moon is proposed. A CDMA system for the fleet of CubeSats in the vicinity of the moon to communicate with the Earth station is considered. This is an extension of our previous proposed CDMA system for a concept Constellation of CubeSats. In this paper the Doppler effects on CDMA communication system performance for a constellation of CubeSats around the Moon will be investigated. As an example we have estimated the maximum Doppler and Doppler rate profile of a SOLARA/SARA CubeSat scenario. We investigate the Effects of Doppler Shift/Rate on the CDMA system performance as a result of the CubeSat constellation orbiting in a halo orbit around Earth-Moon Lagrange Point L1. A detailed analysis and simulation of system in presence of Doppler frequency and unknown carrier phase will be performed. First we define the CDMA system for uplink and downlink between the vicinity of the Moon and Earth station. Link budgets will be provided both for uplink and downlink. Bandwidth limitations imposed by the spectral standards will be investigated for modulation formats. All system simulations are done using Simulink Matlab platform. For highly efficient nonlinear power amplifiers, we prefer to use a filtered offset QPSK with phase modulation, which is a CCSDS standard for constant envelope signaling. This allows us to use a nonlinear amplifier at CubeSat to operate at saturation point for the highest efficiency. Filtered offset QPSK with phase modulation is much more bandwidth efficient scheme. We demonstrate that this modulation format satisfies the two international spectral standards. For estimated and specified Doppler frequencies and Doppler rates we design frequency-tracking loops to track the Doppler frequency and Doppler rate in the presence of data with filtered offset QPSK with phase modulation. For carrier phase offsets a well-designed tracking loop is derived with specified loop bandwidth for the same modulation format. We use the CCSDS standard LDPC codes for space applications to meet the link budget margins.
Eco-Helping and Eco-Civic Engagement in the Public Workplace

ABSTRACTDespite growing interest in the environmental performance and management of public organizations, relatively little is known about the steps individual public employees are taking at their own discretion to promote environmental sustainability and environmental stewardship in the workplace. This article examines public employees’ participation in eco-helping and eco-civic engagement in the workplace. Eco-helping occurs when employees encourage colleagues to perform pro-environmental behaviors in the workplace; eco-civic engagement refers to employees’ voluntary participation in the organization’s pro-environmental activities. The research objective is to identify motivational and attitudinal correlates of eco-helping and eco-civic engagement in the public workplace. Findings suggest that environmental concern and public service motivation (PSM) have positive relationships with both eco-helping and eco-civic engagement in the public workplace. Organizational commitment, however, is only positively ...
Theoretical Purity Versus Theoretical Layering in Marriage and Family Therapy

There seem to be two competing streams of thought about the use of theory in the marriage and family therapy literature: theoretical purity versus integrationism. We examined influence of theoretical orientation on client experience in therapy. Level of academic training (masters' versus doctoral degree) was investigated as a possible confounding variable. Results suggest that therapists in private practice are less inclined to practice pure forms of therapy.
Pain in the Burn Rehabilitation Patient

Burn injury results in painful disruption of the body’s outermost protective tissue barrier, which can lead to alterations in local perfusion, systemic metabolism, temperature regulation, and immune competence, along with increased risk for numerous painful and debilitating musculoskeletal and neurologic complications. Pain associated with burn spans from the moment of injury to beyond wound healing and is exacerbated during rehabilitation by exercise and regular wound care that also provoke anxiety. Pain consists of both nociceptive and neuropathic contributions and is significantly compounded by psychological influences, requiring management that integrates diverse approaches. This chapter provides a broad overview of the clinical treatment options for managing pain in the burn rehabilitation patient. Pharmacologic treatments and early measures, rehabilitation, psychological and psychiatric management, and interventions and surgery are presented along with potential treatment complications. Current developments in burn pain management are discussed. Recommendations are evidence-based and are a practical resource for the rehabilitation practitioner.
"Holistic Interpersonal Mindfulness: Activities and Applications of Coformation Theory"

Abstract Most therapy involves situations involving some aspect of interpersonal functioning. Helping clients recognizing the relational, multifaceted dimensions of holistic intelligence or consciousness is an important function of coformation theory. This article addresses client holistic interpersonal functioning by guiding the reader through activities that can enhance clients being interpersonally mindful in a mental, physical, emotional, and spiritual way. Client vignettes including the application of coformation theory are provided.
Whose Crying Game? One Woman of Color's Reflection on Representations of Men of Color in Contemporary Film

This film review of The Crying Game critically interrogates the politics of representation and domination which “spectacleize” Black male bodies. Working out of her location as an Asian American woman who is sensitive to the cinematic and everyday politics of exoticization, this cultural critic provides an analysis of the dynamic relations of power at work in the racial and heterosexual production and exploitation of Black gays in contemporary film. Drawing on the work of such critics as bell hooks, Robert Reid-Pharr, Kobena Mercer, and Judith Butler, she challenges us not to simply perpetuate the imperial gaze.
Computing elastic anisotropy to discover gum-metal-like structural alloys

The computer aided discovery of structural alloys is a burgeoning but still challenging area of research. A primary challenge in the field is to identify computable screening parameters that embody key structural alloy properties. Here, an elastic anisotropy parameter that captures a material's susceptibility to solute solution strengthening is identified. The parameter has many applications in the discovery and optimization of structural materials. As a first example, the parameter is used to identify alloys that might display the super elasticity, super strength, and high ductility of the class of TiNb alloys known as gum metals. In addition, it is noted that the parameter can be used to screen candidate alloys for shape memory response, and potentially aid in the optimization of the mechanical properties of high-entropy alloys.
The Anti-inflammatory Effect of Personalized Omega-3 Fatty Acid Dosing for Reducing Prostaglandin E2 in the Colonic Mucosa Is Attenuated in Obesity

This clinical trial developed a personalized dosing model for reducing prostaglandin E2 (PGE2) in colonic mucosa using ω-3 fatty acid supplementation. The model utilized serum eicosapentaenoic acid (EPA, ω-3):arachidonic acid (AA, ω-6) ratios as biomarkers of colonic mucosal PGE2 concentration. Normal human volunteers were given low and high ω-3 fatty acid test doses for 2 weeks. This established a slope and intercept of the line for dose versus serum EPA:AA ratio in each individual. The slope and intercept was utilized to calculate a personalized target dose that was given for 12 weeks. This target dose was calculated on the basis of a model, initially derived from lean rodents, showing a log-linear relationship between serum EPA:AA ratios and colonic mucosal PGE2 reduction. Bayesian methods allowed addition of human data to the rodent model as the trial progressed. The dosing model aimed to achieve a serum EPA:AA ratio that is associated with a 50% reduction in colonic PGE2 Mean colonic mucosal PGE2 concentrations were 6.55 ng/mg protein (SD, 5.78) before any supplementation and 3.59 ng/mg protein (SD, 3.29) after 12 weeks of target dosing. In secondary analyses, the decreases in PGE2 were significantly attenuated in overweight and obese participants. This occurred despite a higher target dose for the obese versus normal weight participants, as generated by the pharmacodynamic predictive model. Large decreases also were observed in 12-hydroxyicosatetraenoic acids, and PGE3 increased substantially. Future biomarker-driven dosing models for cancer prevention therefore should consider energy balance as well as overall eicosanoid homeostasis in normal tissue. Cancer Prev Res; 10(12); 729-37. ©2017 AACR.
Integrating Visualization Applications, such as ParaView, into HEP Software Frameworks for In-situ Event Displays

ParaView is a high performance visualization application not widely used in High Energy Physics (HEP). It is a long standing open source project led by Kitware and involves several Department of Energy (DOE) and Department of Defense (DOD) laboratories. Futhermore, it has been adopted by many DOE supercomputing centers and other sites. ParaView is unique in speed and efficiency by using state-of-the-art techniques developed by the academic visualization community that are often not found in applications written by the HEP community. In-situ visualization of events, where event details are visualized during processing/analysis, is a common task for experiment software frameworks. Kitware supplies Catalyst, a library that enables scientific software to serve visualization objects to client ParaView viewers yielding a real-time event display. Connecting ParaView to the Fermilab art framework will be described and the capabilities it brings discussed.
Capacitance Extraction With Provably Good Absorbing Boundary Conditions

3-D field solvers have become popular tools for parasitic capacitance extraction of full custom circuits, IPs, and packages. Traditional field solvers based on finite difference method/finite element method/floating random walk truncate the field on the outer boundary of the numerical region by applying Dirichlet or Neumann boundary conditions. However, to ensure high accuracy in the vicinity of circuit elements, a substantial gridded region between the circuit and the outer boundary is necessary in order to reduce distortion of the field caused by these truncation conditions. In this paper, we make a fundamental contribution to the application of numerical field solvers by proposing a class of absorbing boundary conditions, which when implemented, significantly reduce the distortion of the field at the numerical boundary, and consequently, throughout the numerical region. The absorbing boundary condition we propose will allow the field throughout the numerical region to behave as though there is no numerical boundary, accurately mimicking the fields in an actual circuit. As a result, the size of the numerical region can be significantly reduced, which in turn reduces the run time without sacrificing accuracy. A mathematical development of the proposed absorbing boundary condition is presented. It is shown that the error of the proposed ${n}$ th order absorbing boundary is ${O(1/r^{n+2})}$ , while the error of the traditional Neumann boundary is ${O(1/r^{2})}$ , where ${r}$ is the size of the numerical region. Experimental results for capacitance extraction with interconnects in multilayer dielectrics and silicon on insulator show the proposed methods improve the run time and accuracy of numerical solutions of Laplace’s equation over previous boundary conditions for uniform or nonuniform meshes.
Reducing Wait Time Between Admission and Chemotherapy Initiation.

Purpose:Reducing the length of stay is a high-priority objective for all health care institutions. Delays in chemotherapy initiation for planned preadmissions lead to patient dissatisfaction and prolonged length of stay.Patients and Methods:A multidisciplinary team was formed as part of the ASCO Quality Training Program. We aimed to reduce the time to initiation of chemotherapy from patient arrival at Parkland Hospital from a median of 6.2 hours at baseline to 4 hours over a 6-month period (35% reduction). The team identified inconsistency in blood work requirements, poor communication, and nonstandard patient arrival times as key causes of delay in the process. Plan-Do-Study-Act (PDSA) cycles were implemented based on identified improvement opportunities. The outcome measure was time from arrival to chemotherapy start. Data were obtained from time stamps in the electronic health record.Results:The first PDSA cycle included patient reminders to arrive at specific times, improved communication using a smar...
Therapeutic trials in the murine model of hereditary tyrosinaemia type I: a progress report.

We have studied a knockout mouse with fumarylacetoacetate hydrolase (FAH) deficiency as a model of human hereditary tyrosinaemia type I (HT1). These mice have a phenotype very similar to the human disease, which is characterized by acute hepatic failure, renal tubular disease and hepatocarcinoma. We have previously reported on the efficacy of 2-(2-nitro-4-trifluoromethylbenzyol)-1,3-cyclohexanedione (NTBC) in preventing acute liver disease in HT1 mice. Here we present a progress report on long-term follow up (>1 year) of high-dose NTBC therapy in combination with tyrosine restriction. In vivo retroviral gene therapy was also effective in abolishing the acute liver failure of HT1. Retrovirally treated mice remained completely healthy and active for 12 months after retroviral gene transfer. However, hepatocarcinoma developed in 2/3 treated animals after 1 year. Southern blot analysis showed that the tumours did not arise from retrovirally transduced hepatocytes but from non-corrected FAH-deficient cells. These results highlight the extreme danger for tumour formation in HT1 and indicate the need for improved gene therapy that leads to the elimination of endogenous FAH-deficient liver cells.
EFFECT OF PULSING ELECTROMAGNETIC FIELD ON THE GROWTH OF CHICK EMBRYO: A PRELIMINARY STUDY

ABSTRACT We have investigated the effect of pulsing electromagnetic field on the growth rate of chick embryo. Test and control groups of fertilized eggs were incubated in separate incubators with the test group subjected to a pulsed electromagnetic field. Both lengths and weights of the electromagnetically stimulated embryos were higher than the controls for most groups starting at the 7th day of incubation. The tibias and metatarsals were also longer in the test group compared to controls indicating increased rate of skeletal growth due to electromagnet stimulation.
What I Learned in 25 Years of Teaching Introductory Biomechanics

This paper presents observations and insights obtained during two and one-half decades of teachingintroductory biomechanics. These observation fall into two categories: those concerning the subjectmatter itself and those concerned with teaching the material. Conclusions and recommendations aregiven. For the subject matter, biomechanics is divided into three major areas: performance, injury(or illness), and rehabilitation (or health care). The procedures employed include modeling,analysis, validation, and experimentation. Regarding instruction, it is recommended that thesubject be taught simultaneously in three areas: (1) an overview discussing broad applications,(2) accelerated remediation in mechanics, and (3) basic biomechanics itself.
Local Isoformal Deformation Theory for Meromorphic Differential Equations Near an Irregular Singularity

These lectures will be concerned with isoformal deformations of meromorphic differential equations in the neighborhood of an irregular singular point. The corresponding analytic moduli space is constructed ana is shown tc be the quotient of a complex affine space by an affine algebraic group. This theory is based, among other things, on a deformation theory of nilpotent matrices over fairly general rings that seems to have independent interest.
Surgical Management of NTM Diseases

Prior to the discovery of antimicrobial medications, treatment of mycobacterial disease was primarily supportive. The development of many thoracic surgical techniques was in large part due to attempts to treat tuberculosis and its complications. While antibiotic therapy is the mainstay treatment for nontuberculous mycobacterial (NTM) infections today, cure rates with medication alone remain low. In experienced centers, a multidisciplinary approach employing antibiotic therapy and surgical resection has been shown to be effective in eradicating NTM infections in highly selected patients. This chapter will present proposed indications for surgical intervention in patients with NTM disease, the recommended preoperative evaluation of potential surgical patients, surgical techniques, post-op management, and management of postsurgical complications. Additionally, surgical management for extrapulmonary infections is discussed.
Pervasive gene conversion in chromosomal inversion heterozygotes.

Chromosomal inversions shape recombination landscapes, and species differing by inversions may exhibit reduced gene flow in these regions of the genome. Though single crossovers within inversions are not usually recovered from inversion heterozygotes, the recombination barrier imposed by inversions is nuanced by noncrossover gene conversion. Here, we provide a genomewide empirical analysis of gene conversion rates both within species and in species hybrids. We estimate that gene conversion occurs at a rate of 1 × 10-5 to 2.5 × 10-5 converted sites per bp per generation in experimental crosses within Drosophila pseudoobscura and between D. pseudoobscura and its naturally hybridizing sister species D. persimilis. This analysis is the first direct empirical assessment of gene conversion rates within inversions of a species hybrid. Our data show that gene conversion rates in interspecies hybrids are at least as high as within-species estimates of gene conversion rates, and gene conversion occurs regularly within and around inverted regions of species hybrids, even near inversion breakpoints. We also found that several gene conversion events appeared to be mitotic rather than meiotic in origin. Finally, we observed that gene conversion rates are higher in regions of lower local sequence divergence, yet our observed gene conversion rates in more divergent inverted regions were at least as high as in less divergent collinear regions. Given our observed high rates of gene conversion despite the sequence differentiation between species, especially in inverted regions, gene conversion has the potential to reduce the efficacy of inversions as barriers to recombination over evolutionary time.
Does seminal vesicle-sparing robotic radical prostatectomy influence postoperative prostate-specific antigen measured with an ultrasensitive immunoassay?

PURPOSE Sparing of the seminal vesicles during robotic radical prostatectomy (SVRP) is an attempt to reduce potential damage to the hypogastric pelvic nerves. However, the seminal vesicles are known to express prostate-specific antigen (PSA) and it is unknown whether SVRP influences oncological outcome measured with ultrasensitive PSA immunoassays. In a retrospective study we analysed whether SVRP affects oncological outcome in terms of ultrasensitive PSA nadir and biochemical recurrence as compared with standard robotic assisted laparoscopic radical prostatectomy (sRALP). METHODS Overall, 102 patients underwent robotic prostatectomy. Patients were non-randomly allocated to the following surgical techniques: a SVRP group of 39 patients who underwent robotic radical prostatectomy sparing the tips of the seminal vesicles; a standard group of 63 patients who were treated with sRALP. Inclusion criteria were histologically proven negative margins (R0) and negative lymph node status (pN0). PSA was measured with an ultrasensitive assay. The Mann-Whitney U-test was used to compare the differences in PSA nadir and follow-up PSA. Biochemical recurrence was diagnosed if PSA rose to ≥0.2 mg/ml. RESULTS Median (range) follow-up was 31.4 (16.4–43.8) months. Preoperative PSA was 5.8 (0.13–15.29) ng/ml in the SVRP group and 7.1 (0.8–46) ng/ml in the sRALP group. Two cases of biochemical recurrence occurred in the sRALP group during follow-up. One of these two patients presented with locally advanced prostate carcinoma diagnosed from the definitive pathological specimen (pT3b). No patient of the SVRP group had seminal vesicle invasion or biochemical recurrence. No significant between-group difference in terms of PSA nadir and follow-up PSA was recorded. However, the percentage of patients who did not reach PSA nadir values of <0.01 ng/ml was higher in the SVRP group (10 vs 5% in the sRALP group). CONCLUSIONS Compared with sRALP, SVRP had no clinical impact on oncological outcome in terms of PSA nadir or biochemical recurrence measured with an ultrasensitive PSA immunoassay. A slightly higher PSA nadir after SVRP seems to be expected, which needs to be mentioned during follow-up of these patients.
Learning to localize a broadband tonal complex signal with advanced hearing protectors and TCAPS: the effectiveness of training on open-ear vs. device-occluded performance.

(1) determine if untrained, normal-hearing listeners could learn, with regimented practice trials, to localise a dissonant tonal complex while wearing electronic hearing protectors and achieve equi...
Mechanisms of resistance to CAR T cell therapy

The successes with chimeric antigen receptor (CAR) T cell therapy in early clinical trials involving patients with pre-B cell acute lymphoblastic leukaemia (ALL) or B cell lymphomas have revolutionized anticancer therapy, providing a potentially curative option for patients who are refractory to standard treatments. These trials resulted in rapid FDA approvals of anti-CD19 CAR T cell products for both ALL and certain types of B cell lymphoma - the first approved gene therapies in the USA. However, growing experience with these agents has revealed that remissions will be brief in a substantial number of patients owing to poor CAR T cell persistence and/or cancer cell resistance resulting from antigen loss or modulation. Furthermore, the initial experience with CAR T cells has highlighted challenges associated with manufacturing a patient-specific therapy. Understanding the limitations of CAR T cell therapy will be critical to realizing the full potential of this novel treatment approach. Herein, we discuss the factors that can preclude durable remissions following CAR T cell therapy, with a primary focus on the resistance mechanisms that underlie disease relapse. We also provide an overview of potential strategies to overcome these obstacles in an effort to more effectively incorporate this unique therapeutic strategy into standard treatment paradigms.
The First Mixed-Halide Zirconium Cluster Compounds: Zr(6)Cl(1.6)I(10.4)Be, Zr(6)Cl(1.3)I(10.7)B, and Zr(6)Cl(11.5)I(1.5)B. Matrix Effects and Halogen Substitution in Compact Network Structures.

Investigations of the effect of halogen size on structure stability have been conducted in well-reduced and heavily interbridged zirconium chloride-iodide cluster systems. The title compounds are obtained in good yields from reactions of Zr, ZrCl(4), ZrI(4), and B or Be in sealed Ta tubes for approximately 4 weeks at 850 degrees C. Single-crystal diffraction at room temperature established these as Zr(6)Cl(1.65(4))I(10.35(4))Be and Zr(6)Cl(1.27(3))I(10.73(3))B [Rt, Z = 3, a = 14.3508(8), 14.389(1) A, c = 9.8777(9), 9.915(2) A, respectively] and Zr(6)Cl(11.47(2))I(1.53(2))B [P4(2)/mnm, Z = 2, a = 12.030(1) A, c = 7.4991(8) A]. These are derivatives of the Zr(6)I(12)C and orthorhombic Zr(6)Cl(13)B structures, respectively, the latter containing unusual linear chains of clusters interbridged by Cl(i-i) that are in turn interconnected by three-bonded Cl(a-a-a) atoms. The random substitution of fractional Cl at specific I sites in the first two, and I for certain Cl in the third, was positionally resolved in all cases. The replacement always occurs at two-bonded X(i), so that single types of halogen are left in sites that interconnect clusters and generate the three-dimensional array. Structural changes seen in both structures are specifically related to relief of X.X crowding in the parent structure (matrix effects). Substitution of Cl for I(i) in the Zr(6)I(12)C type greatly reduces intercluster I.I repulsions and allows, among other things, a 0.20 A (5.8%) reduction in Zr-I(a-i) intercluster bond lengths. Increased Cl.I repulsions caused by I substitution in orthorhombic Zr(6)Cl(13)B (Pnnm) convert the twisted chains and angular Cl(a-a-a) interchain bridges to planarity in tetragonal Zr(6)Cl(11.5)I(1.5)B. Phase widths found are 0 </= x </= 1.4 for Zr(6)Cl(x)()I(12)(-)(x)()Z (Z = B, Be) and 0 </= x </= 1.5 for Zr(6)Cl(13)(-)(x)()I(x)()B. The limit for iodine substitution in the chlorine-rich rhombohedral Zr(6)Cl(12)(-)(x)()I(x)()Be is about x = 2.5.
Coprescription of opioid and naloxone in office-based practice and emergency department settings in the United States.

Abstract Objectives The objective of the study was to estimate the national rates of naloxone coprescribing with opioids in office-based practice and emergency department (ED) settings in the United States (US). Study design This study is a cross-sectional study. Methods We used the National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medical Care Survey (NHAMCS) datasets to estimate the national rates of naloxone coprescribing with opioids for the period 2014–2016. The analysis was stratified into office-based practice and ED settings. In ED settings, opioid and naloxone could be given to patients while they were in ED or as a prescription at discharge. Patients of all ages were considered for the analysis and sampling weights were applied to estimate national rates. Results In office-based settings, 7918 sample visits included one or more opioid prescriptions (10.67 per 100 office visits). Of those, one included naloxone as a coprescription. In ED settings, the opioid prescription was given at discharge in 6124 sample visits (9.68 per 100 ED visits). Of those, two included naloxone as a coprescription. On the other hand, opioid was given to patients in the ED in 8811 sample visits (13.57 per 100 ED visits). Of those, 30 included naloxone as a coprescription. Conclusions The rates of naloxone coprescribing with opioids were extremely low in office-based and ED settings in the US. Expanding access to naloxone is a key component of the public health response to the opioid crisis. Based on our study findings, promoting the coprescription of naloxone with opioids may provide greater access to naloxone for those who are at risk of opioid overdose.
Improving LMP based Day Ahead Forecasts Using Auto Regressive Integrated Moving Average (ARIMA) with Shadow Pricing, EFORd Rates, and Transmission Loss Ratios

In this paper, forecasting methods for Day Ahead Locational Marginal Pricing (DA LMP) are investigated for PJM markets. Specifically, we explored the influence of parameters such as EFORd Rates, Shadow Pricing (SP) and Transmission Loss Ratios (TLR) in the data sets with forecasting models such as ARIMA, exponential smoothing, and Monte-Carlo methods (e.g., embedded in RT-Sim commercial software). Specifically, the approach used in this study is different from that of traditional methods as forecasting models are trained with EFORd, SP and TLR to investigate the effect of three LMP variables: Energy cost, Loss and Congestion. The methods relied on last one week of historical data to predict the day-ahead LMP, and its results were compared against PJM's forecasting methods for a known historic date. Our goal was to study the effect of three different parts that makeup LMP and use them rather than traditional trend pricing and weather variables to predict DA LMP pricing. Our preliminary findings indicate that using EFORd, SP and TLR for PJM's peak outage season coupled with conventional data appears to improve forecast accuracy nearly 9% (MAPE value) as compared to PJM's forecasting approach.
Study on Fault Control Requirement and Strategy of Large Scale Renewable Energy VSC-HVDC Integration

Although domestic and foreign research institutions have obtained some research results in related fields, they have not conducted in-depth research on the interaction between VSC DC grid and renewable energy, and on the fault rid though and coordinated control technology of VSC DC grid and renewable energy joint system. Most studies have focused on the fault ride though of the system in the case of AC power grid short-circuit faults in renewable energy power plants and peer-to-peer VSC DC grid systems. Basically, the impact of VSC DC grid system faults on the grid connection of renewable energy is not considered. Although the above research results can suppress the rise of DC voltage and provide technical support as a joint fault ride though of renewable energy and DC grid, the system can achieve fault ride though. However, various fault ride though methods will inevitably have a certain impact on the renewable energy generators, and even have an impact on the regulations and standards for renewable energy connected to the DC power system. Therefore, from the perspective of the safety protection of renewable energy, it is necessary to consider the fault ride though method when the AC grid fails in the VSC DC transmission mode. The transmission of Zhangbei renewable energy through the VSC grid is a complex system with multiple wind farms and multi-terminal DC. It is necessary to carry out detailed research in different working conditions and sub-modes. This paper provides the study on fault control requirement and strategy of large scale renewable energy connected to VSC DC grid, and tries to explore potential challenge caused by the integration of renewable energy generation into VSC DC grid.
Chapter 8 – Amphibians

Hybridizing tree frogs are among the creatures highlighted in this short chapter. The genetic findings on a hybrid population of tree frogs also provided the primary motivation for a collaborative development and deployment of a novel theory of cytonuclear disequilibria that applies to population-level associations between nuclear and cytoplasmic alleles or genotypes. This research exemplifies how molecular data can both motivate and be informed by population genetic theory.
Transjugular Intrahepatic Portosystemic Shunts in High-Risk Patients

Cirrhosis with complications of portal hypertension portends a poor prognosis. Transjugular intrahepatic portosystemic shunts (TIPS) can successfully treat some of these complications in select patients. While the safety and efficacy of TIPS have improved significantly over the past decade, certain patients are categorized as high-risk based on various demographic, laboratory, and comorbid factors. Herein, we provide an in-depth review of TIPS in these settings, including high model for end-stage liver disease score, hepatic malignancy, advanced age, cardiac disease, renal dysfunction, and pregnancy, and discuss their impact on patient selection and procedural considerations.
Neuroanatomical Models of Muscle Strength and Relationship to Ambulatory Function in Spinal Muscular Atrophy.

BACKGROUND Individuals with spinal muscular atrophy (SMA) III walk independently, but experience muscle weakness, gait impairments, and fatigue. Although SMA affects proximal more than distal muscles, the characteristic pattern of selective muscle weakness has not been explained. Two theories have been proposed: 1) location of spinal motor neurons; and 2) differences in segmental innervation. OBJECTIVE To identify neuroanatomical models that explain the selective muscle weakness in individuals with SMA and assess the relationship of these models to ambulatory function. METHODS Data from 23 ambulatory SMA participants (78.2% male), ages 10-56 years, enrolled in two clinical studies (NCT01166022, NCT02895789) were included. Strength was assessed using the Medical Research Council (MRC) score; ambulatory function was measured by distance walked on the 6-minute walk test (6 MWT). Three models were identified, and relationships assessed using Pearson correlation coefficients and linear regression. RESULTS All models demonstrated a positive association between strength and function, (p < 0.02). Linear regression revealed that Model 3B, consisting of muscles innervated by lower lumbar and sacral segments, explained 67% of the variability observed in 6 MWT performance (β= 0.670, p = 0.003). CONCLUSIONS Muscles innervated by lower lumbar and sacral segments, i.e. hip extensors, hip abductors, knee flexors and ankle dorsiflexors, correlated with and predicted greater ambulatory function. The neuroanatomical patterns of muscle weakness may contribute to a better understanding of disease mechanisms and enable delivery of targeted therapies.
The Impossible Possibility of Palmquist’s Kant and Mysticism

Stephen R. Palmquist’s Kant and Mysticism revisits his earlier work on Kant and Swedenborg, arguing that, contrary to standard interpretations, the arguments of Dreams of a Spirit-Seer expand into ‘Critical mysticism’ throughout the Critical philosophy and into the Opus Postumum. Although the beginning portions of Palmquist’s book successfully disturb the standard portrait of Kant as the all-destroyer of metaphysics and religious experience, his argument for critical mysticism is inconclusive. It is impossible to know if his interpretation of the Opus Postumum is more right than its competitors. The conflict of interpretations shows Palmquist’s interpretation to be a hermeneutic impossible possibility.
Applying Web-based Application ExpressDecision2 in Patient-Centered Care

ExpressDecision2® (ED2®) is a web app designed to support the individual in quickly making difficult decisions under uncertainty, which are emotionally driven and typically solved by using rational intuition. ED2 is based on the self-regulation model of the thinking process developed within the framework of the systemic-structural activity theory. ED2 supports both decision-making and problem-solving processes. For problem-solving, ED2 supports goal-setting by implementing the principle of instrumental rationality. Paper demonstrates of ED2’s application in making a patient-centered and shared-with-doctor decision about the best treatment option for cholesterol reduction.
Jan Mukařovský ressuscitado: o que resta hoje da Escola de Praga?

This essay presents a broad overview of Czech structuralism as developed by the Prague School, taking as reference the work of one of its main members: Jan Mukařovský. The study also discusses the problem of international neglect the with regard to the recognition of the School's work, particularly by French intellectuals. In the correlation of Mukařovský's work with more recent (literary) theories, it is considered, in general lines, among others, important aspects of New Criticism, Poststructuralism and Deconstruction.
The Impact Of COVID-19 Restrictions on an Academic Hand Surgery Practice

Purpose The impact of the SARS-CoV-2 (COVID-19) coronavirus has been felt worldwide, impacting all aspects of healthcare. We examined the quantitative impact during the first four weeks of hospital system and state-mandated restrictions on elective healthcare on an academic urban hand surgery practice. We hypothesized that the volume of overall ambulatory clinic encounters, office procedures, and surgical procedures and cases would dramatically decrease during this time and that the volume of non-elective care would remain unchanged. Methods We retrospectively reviewed all patient encounters in a 4-week time period from March 16, 2020 through April 12, 2020 for an academic orthopedic hand surgery practice and compared those to two control 4-week time periods: February 17, 2020 through March 15, 2020 and March 16, 2019 through April 12, 2019. Weekly encounter volumes and work relative value units (RVUs) were obtained for ambulatory clinic encounters, office procedures, and surgical procedures and cases. The type of ambulatory visit, in-person or telemedicine was also identified. Surgical cases were categorized into four types: fracture or dislocation, acute soft tissue or nerve injury, infection, or elective/non-urgent for the two most recent time periods. T-tests were performed to compare weekly volume and RVUs between time periods. Results After the implementation of mandated restrictions on elective healthcare, ambulatory hand surgery clinic encounters decreased 72-73%, clinic procedures decreased by 87-90%, and surgical cases decreased by 87-88%. The percentage of ambulatory visits performed via telemedicine increased from 0.06% to 74%. Similar impacts on RVUs were seen. All elective surgery was deferred. Surgeries for fractures and dislocations declined by 58% and those for acute soft tissue or nerve injury declined by 40%; the number of surgical procedures for infection remained unchanged. Conclusions The COVID-19 restrictions on elective healthcare led to an immediate, substantial impact on hand surgery practice. There was a significant decrease in ambulatory encounter volume, office procedures, and surgical cases. Non-elective surgical case volume also decreased by 47%. The long-term financial impact of this change in practice on providers, practices, patients and hospitals is still to be determined but based on the quantitative impacts seen, is likely to be substantial.
Wireless Sensors for Measuring Wind-Borne Pressures During Hurricanes

A third generation of wireless sensors was developed to study wind-borne pressure variations in low-rise buildings during hurricanes. The system has the capability of measuring pressure and temperature along a roof, collecting data and sending it to a server to process and publish on the web in near real-time. Also wind speed and direction are measured by the system with the use of an anemometer. Sensors are placed inside individual custom-made plastic weatherproof cases. Small size of all components allows an aerodynamic shape, reducing the shape effect of the sensor on the flow. Low power consumption combined with Li-Ion batteries provide several days of continuous data collection. The platform created allows using almost any type of sensor via a planned expansion port. The paper presents some preliminary results.
Investigating the Effects of Specimen Thickness and Pressure on the Crack Growth Behavior of a Particulate Composite Material

In this study, the effects of specimen thickness and confined pressure on the crack growth behavior in a particulate composite material, containing hard particles embedded in a rubber matrix, were investigated. The experimental data were analyzed and the results are discussed.
The Income Tax Structure's Impact on Growth, Valuation, and Global Investments: A Three Stakeholder Perspective

We extend Modigliani and Miller's value conserving capital structure model by adding government as the third major financial stakeholder, through collection of taxes. We demonstrate that the burden of corporate taxation eventually falls on shareowners. By shifting the tax incidence to individuals, government's tax revenues rise despite its declining proportional stake in firms. Our empirical analysis of 108 countries during 1991 to 2004 finds that a 1% increase in corporate tax results in 0.2% decrease in growth rate, 2% decrease in valuation and 0.3% decrease in investment. The effect of personal taxes is much less significant.