cssi/SciSciGPT-SciSciNet huggingface dataset:
Measurement of δ18O values in arsenic and selenium oxyanions.

RATIONALE Past stable isotopic studies of selenium and arsenic oxyanions within a biogeochemistry context have focused solely on selenium isotopes due to monoisotopic nature of arsenic and lack of attention to oxygen. A modern quantification method of δ18O values in selenate, selenite, arsenate, and arsenite is presented here, similar to methods for other inorganic oxyanions such as phosphate. METHODS Dissolved oxyanions were recovered after precipitation with silver or barium cations within controlled pH ranges and purified by drying and roasting under vacuum. Oxygen isotope ratio measurements were performed on 250–450 micrograms of solids using continuous flow high-temperature conversion elemental analyzer/isotope ratio mass spectrometry (CF-TCEA/IRMS). Each Se and As solid was evaluated for reproducibility and stability of δ18O values and the usefulness of this method for evaluating aqueous phase Se and As oxyanion reactions was addressed. RESULTS Only silver arsenate and barium selenate were shown to have stable, reproducible δ18O values over 5 months and were calibrated to the VSMOW scale. The method was applied to confirm complete exchange of oxygen isotopes between arsenate and solvent water at pH 7 which produced an O-isotope fractionation between arsenate and water of 6.0‰. Furthermore, the method revealed the ability of oxygen in selenate to kinetically fractionate during reduction to elemental selenium by a green rust compound which produced a fractionation (20.9‰) larger than reported δ80/76Se values for similar reactions. CONCLUSIONS The experimental and analytical conditions for δ18O analysis of Se and As oxyanions were detailed. δ18O analyses of As and Se oxyanions may be useful in biogeochemical studies for tracing chemical reaction pathways, determining environmental sources of Se, or diagnosing specific reaction mechanisms for As and Se oxyanions. Copyright © 2012 John Wiley & Sons, Ltd.
Review Essay: Larry May, Genocide: A Normative Account

Recent years have tested the definition of the crime of genocide, with mass atrocities in the Balkans, Rwanda, and Sudan sparking controversy over their legal characterization, and with a proliferation of international criminal tribunals and the International Court of Justice called upon to adjudicate. At times, the focus on genocide has threatened to become a distraction, as if to label these crimes something other than genocide is to diminish their gravity, rendering their victims less victimized, or less worthy of international attention. Lurking behind the technical, definitional debates, moreover, is a deeper question regarding the very coherence of genocide as a distinct offense. Is the crime reducible to a normatively satisfying legal definition, one that identifies distinct harms deserving of separate legal recognition. Or perhaps is the symbolic weight of genocide more than the law can bear?The bulk of May’s argument develops a qualified normative justification of genocide as a crime focused on a distinct harm: the loss of identity and status suffered by members of groups on account of efforts to destroy to the group. This justification, May argues, flows from his nominalist position that groups themselves have no independent ontological status and thus cannot be said to suffer harms. The unique harm of genocide, therefore, is one suffered by victims whose lives find meaning in the inter-subjective experience of group identity. The central difficulties in the law of genocide are not, of course, ones of May’s making, and his book deserves credit for carefully revealing both the necessity of a normative justification and the complex nature of that project. Whether May succeeds in justifying the offense’s group-based focus is a more debatable question. I suspect that May’s readers may be equally inclined to abandon the idea of genocide as a meaningful legal concept, or perhaps to agree with David Luban that the concept of genocide must extend beyond group destruction to include all large scale massacres that are currently proscribed by the crime against humanity of extermination. In either event, Genocide: A Normative Account will be required reading for those pursuing these questions.
H8Si8O12 Clusters on Si(100)-2×l and Gold: A Comparative Infrared Spectroscopic Study

Reflection-absorption infrared data are presented for H8Si8O12 clusters chemisorbed to Si(100)-2×1 and evaporated gold surfaces. Peak assignments and the implications of the local symmetry imposed upon the cluster by the surface are discussed.
Improving surveillance for pediatric Clostridium difficile infection: Derivation and validation of an accurate case-finding tool

Background:The incidence of Clostridium difficile infection (CDI) is increasing. Multicenter studies of CDI have been limited by the lack of valid case-finding tools. To facilitate pediatric studies of CDI, we constructed a case-finding tool using administrative data.Methods:A cross-sectional study
Two-Dimensional Solvent-Mediated Phase Transformation in Lipid Membranes Induced by Sphingomyelinase

The spatial pattern changes in model raft membranes during sphingomyelinase (SMase)-induced solvent-mediated phase transformation are characterized in terms of a model that combines three major kinetic processes suggested by experimental observations: the release of sphingomyelin (SM) by the dissolution of SM-enriched domains within the raft membrane, the diffusion of SM from the dissolution sites to the reaction site in a solvent-like fluid lipid phase, and the consumption of SM by the enzymatic reaction at this reaction site, termed an SMase feature. Such processes may be responsible for the control of morphological changes in cell membrane organization, which are suggested to influence the signal transduction through the cell membrane walls. The model predictions are shown to be consistent with our previously reported experimental results. We numerically evaluated the range of possible scenarios of spatial pattern change and provide analytical expressions for SM-domain-area change rates and total disso...
A Deletion in the Gene for Transforming Growth Factor β Type I Receptor Abolishes Growth Regulation by Transforming Growth Factor β in a Cutaneous T-Cell Lymphoma

Spontaneous regression of skin lesions is characteristic of lymphomatoid papulosis (LyP), a clonal cutaneous lymphoproliferative disorder. A minority of LyP patients progress to anaplastic large cell lymphoma (ALCL) in which skin lesions no longer regress and extracutaneous dissemination often occurs. In 1 such case, we developed a tumor cell line, JK cells, and show that these cells are resistant to the growth inhibitory effects of transforming growth factor β (TGF-β) due to the loss of cell surface expression of the TGF-β type I receptor (TβR-I). Reverse transcriptase-polymerase chain reaction (RT-PCR) and sequencing of JK cell TβR-I cDNA clones identified a deletion that spanned the last 178 bp of exon 1, including the initiating methionine. Hybridization of a radiolabeled fragment internal to the deletion was detected in the genomes of TGF-β–responsive cells, but not in JK cells, indicating that they contain no wild-type TβR-I gene. PCR primers that flanked the deleted TβR-I region amplified a single band from JK cell genomic DNA that lacked the last 178 bp of exon 1 and all of the ≈ 5 kb of intron 1. This JK cell-specific genomic TβR-I PCR product was distinct from products amplified from TGF-β–responsive cells and was also readily detected in tumor biopsies obtained before the establishment of the JK cell line. Our results identify the first inactivating mutation in TβR-I gene in a human lymphoma that renders it insensitive to growth inhibition by TGF-β.
Innovation and Price Informativeness

We study whether the innovation decisions of a firm are improved as a result of information reflected in the firm's stock price. We show that firms with more informative stock prices, as measured by price nonsynchronicity, have better innovation outcomes, as measured by the number of patents and patent citations. Our results are not driven by managerial private information and are robust to various alternative specifications. We also find that price informativeness is more important to innovation when managers are less experienced or face greater uncertainty about the optimal innovation strategy, and that these effects are primarily observed in small- and mid-sized firms where additional information may be of greater value. Our results are consistent with the notion that capital markets can have real effects on the economy.
Protein Electrophoretic Findings Suggest IgG4-Related Systemic Disease

Serum protein electrophoresis (SPEP) is routinely performed to detect monoclonal gammopathies. Large polyclonal increases in IgG4 subclass produce a distinctive, relatively broad restriction in the anodal portion of the gamma globulin region. In this study, we sought to determine whether more subtle polyclonal increases in IgG4 detectable by SPEP were associated with a diagnosis of IgG4-related systemic disease (IgG4-RSD). A …
The Use of Hemoperfusion in Children: Past, Present, and Future

Hemoperfusion has been used over the past several years for the treatment of uremia, the treatment of poisoning and drug intoxication, reversal of coma and hepatic failure, and enhancement of clearance of various other noxious substances. This article discusses the development of the technique and describes the use of hemoperfusion in the clinical picture.
Preoperative MRSA Screening in Pediatric Spine Surgery: A Helpful Tool or a Waste of Time and Money?

Objectives To review the use of preoperative screening for Staphylococcus aureus for all pediatric spine procedures that was instituted at our facility in a multimodal approach to decrease the frequency of postoperative wound infections.
Reaction Mechanisms of 10 B(d,α) 8 Be 2.9 (α) 4 He for E d =0.4, 1.0, and 1.5 MeV

The angular correlation of the first-emitted $\ensuremath{\alpha}$ and an $\ensuremath{\alpha}$ from the sequential decay of the $^{8}\mathrm{Be}_{2.9}$ state in the reaction $^{10}\mathrm{B}(d,\ensuremath{\alpha})^{8}\mathrm{Be}_{2.9}(\ensuremath{\alpha})^{4}\mathrm{He}$ strongly suggests that this reaction proceeds by compound-nucleus formation at ${E}_{d}=0.4$ MeV and by a deuteron-pickup direct interaction at ${E}_{d}=1.0 \mathrm{and} 1.5$ MeV. The observed symmetry axis for the $^{8}\mathrm{Be}_{2.9}$ breakup distribution in its own center of mass is compared to the momentum-transfer and recoil directions associated with various possible mechanisms and appears to provide the necessary information to select the mechanism.
Toward a Post-Humanist Organicism

Recent critiques of organicism in music studies have assumed that such features as part–whole integration and end-oriented development are essential to comparisons between music and the organic realm. Yet if what is thought to constitute organicism varies with perspectives on organisms in general, then perhaps it is time to take a different view of organicism’s historical legacy. What if the problem is not with the impression that music presents a semblance of the organic, but with the models of the organism brought in to give content to that semblance? In light of novel accounts of organic life currently being formulated by both scientists and thinkers affiliated with post-humanism, I propose to imagine an organicism that dispenses with humanistic conceits and prompts creative reflection on the points of connection between music and organic processes. To that end, this essay first dismantles conventional notions of wholeness and development before going on to consider aspects of the Western musical tradition through the twin lenses of self-organization and the systems theory of German sociologist Niklas Luhmann. In sum, the essay seeks to conserve affinities between music and the organic domain intuited by nineteenth-century listeners while transposing organicism into a register more in tune with contemporary scientific and philosophical thought. By adding new nodes to a critical network established over two centuries ago, this article argues that a post-humanist organicism challenges us to think afresh about what our bodies, our sociality, and our creativity share with non-human entities and ecologies.
Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction.

Objectives The purpose of this study was to identify cardiovascular features of patients with heart failure with preserved ejection fraction (HFpEF) that differ from those in individuals with hypertensive left ventricular hypertrophy (HLVH) of similar age, gender, and racial background but without failure. Background Heart failure with preserved ejection fraction often develops in HLVH patients and involves multiple abnormalities. Clarification of changes most specific to HFpEF may help elucidate underlying pathophysiology. Methods A cross-sectional study comparing HFpEF patients (n 37), HLVH subjects without HF (n 40), and normotensive control subjects without LVH (n 56). All subjects had an EF of 50%, sinus rhythm, and insignificant valvular or active ischemic disease, and groups were matched for age, gender, and ethnicity. Comprehensive echoDoppler and pressure analysis was performed. Results The HFpEF patients were predominantly African-American women with hypertension, LVH, and obesity. They had vascular and systolic-ventricular stiffening and abnormal diastolic function compared with the control subjects. However, most of these parameters either individually or combined were similarly abnormal in the HLVH group and poorly distinguished between these groups. The HFpEF group had quantitatively greater concentric LVH and estimated mean pulmonary artery wedge pressure (20 mm Hg vs. 16 mm Hg) and shorter isovolumic relaxation time than the HLVH group. They also had left atrial dilation/dysfunction unlike in HLVH and greater total epicardial volume. The product of LV mass index and maximal left atrial (LA) volume best identified HFpEF patients (84% sensitivity, 82% specificity). Conclusions In an urban, principally African American, cohort, HFpEF patients share many abnormalities of systolic, diastolic, and vascular function with nonfailing HLVH subjects but display accentuated LVH and LA dilation/failure. These latter factors may help clarify pathophysiology and define an important HFpEF population for clinical trials. (J Am Coll Cardiol 2007;49:198‐207) © 2007 by the American College of Cardiology Foundation
A Comparison of the Freshwater Macroinvertebrate Assemblages of St. Kitts and Nevis, West Indies

A survey of macroinvertebrates inhabiting the freshwater habitats of St. Kitts and Nevis was conducted during June 1996, May 1997, and January 2000. Qualitative collections were made by sweeping a dip net through the water column and by hand examination of rocks, plants, and debris submerged in both flowing and standing bodies of freshwater across these islands. These collections yielded at least 90 species, 57 from St. Kitts and 61 from Nevis. Many of the species encountered are being reported for the first time from these islands. Dominant taxa collected included several species of gastropods, decapod crustaceans, odonates, hemipterans, and coleopterans. Generally the macroinvertebrate fauna of St. Kitts and Nevis is sparse, most likely due to their oceanic origins and disturbances of their freshwater environments.
Engagement With Online Tobacco Marketing and Associations With Tobacco Product Use Among U.S. Youth

Abstract Purpose Youth who engage with online tobacco marketing may be more susceptible to tobacco use than unengaged youth. This study examines online engagement with tobacco marketing and its association with tobacco use patterns. Methods Cross-sectional analysis of youths aged 12–17 years who participated in wave 1 of the Population Assessment of Tobacco and Health Study (N = 13,651). Engagement with tobacco marketing was based on 10 survey items including signing up for email alerts about tobacco products in the past 6 months. Logistic regression was used to examine the association of online engagement with tobacco marketing and susceptibility to use any tobacco product among never-tobacco users, ever having tried tobacco, and past 30-day tobacco use. Results An estimated 2.94 million U.S. youth (12%) engaged with ≥ one forms of online tobacco marketing. Compared with no engagement, the odds of susceptibility to the use of any tobacco product among never-tobacco users was independently associated with the level of online engagement: adjusted odds ratio (AOR) = 1.48 (95% confidence interval [CI], 1.24–1.76) for one form of engagement and AOR = 2.37 (95% CI, 1.53–3.68) for ≥ two forms of engagement. The odds of ever having tried tobacco were also independently associated with the level of online engagement: AOR = 1.33 (95% CI: 1.11–1.60) for one form of engagement and AOR = 1.54 (95% CI, 1.16–2.03) for ≥ two forms of engagement. The level of online engagement was not independently associated with past 30-day tobacco use. Conclusions Online engagement with tobacco marketing may represent an important risk factor for the onset of tobacco use in youth.
PPGSecure: Biometric Presentation Attack Detection Using Photopletysmograms

Authentication of users by exploiting face as a biometric is gaining widespread traction due to recent advances in face detection and recognition algorithms. While face recognition has made rapid advances in its performance, such facebased authentication systems remain vulnerable to biometric presentation attacks. Biometric presentation attacks are varied and the most common attacks include the presentation of a video or photograph on a display device, the presentation of a printed photograph or the presentation of a face mask resembling the user to be authenticated. In this paper, we present PPGSecure, a novel methodology that relies on camera-based physiology measurements to detect and thwart such biometric presentation attacks. PPGSecure uses a photoplethysmogram (PPG), which is an estimate of vital signs from the small color changes in the video observed due to minor pulsatile variations in the volume of blood flowing to the face. We demonstrate that the temporal frequency spectra of the estimated PPG signal for real live individuals are distinctly different than those of presentation attacks and exploit these differences to detect presentation attacks. We demonstrate that PPGSecure achieves significantly better performance than existing state of the art presentation attack detection methods.
Characterization of LL25X, a Newly Isolated Anti-SIV Monoclonal Antibody, to Determine Binding Specificity

A phage display library was previously constructed from an SIV-infected rhesus macaque. Several single chain Fv (scFv), including SU24, SU343 and LL25X, were selected using phage display technology. Sequences corresponding to SU24, SU343 and LL25X were optimized for expression in a mammalian system and commercially synthesized. SU24 and SU343 had previously been cloned into a mammalian expression vector. In this study, we aimed to characterize the specificity of SU24, SU343, and LL25X.. The codon-optimized version of the scFv LL25X gene sequence was cloned into a mammalian expression vector (pCEP4). LL25X DNA was amplified by PCR, and the PCR product and mammalian expression vector were both digested with KpnI/SapI restriction enzymes. Digested fragments were purified, and the fragments were ligated using T4DNA ligase. E. coli cells were transformed with the ligation reaction. Single colonies were selected on LB agar plates containing the selective antibiotic (ampicillin). Positive colonies were identified after DNA mini-preparation and test-digestion with KpnI and SapI. Sanger sequencing confirmed cloning results and DNA sequence accuracy. Following transfection of mammalian cells (293T), LL25X-Fc cells, and purifying our protein, the binding of LL25X-Fc to the SIV gp140 envelope protein was confirmed via ELISA and Western Blotting.
Impact of Media on Major Choice: Survey of Communication Undergraduates.

Popular and news media sources may play a key role in influencing undergraduate choice of major, yet their unique impact has not been investigated. Most research has focused on the influence of unm...
Educating for Change: How Labor Education Centers and AFL-CIO Bodies Can Grow and Transform Together:

In order to survive and prosper today, both labor councils and labor education centers need to rethink their mission, goals, and strategies. In this report, we examine how partnerships between thes...
Lower-dose epinephrine administration and out-of-hospital cardiac arrest outcomes.

Abstract Background International guidelines recommend administration of 1 mg of intravenous epinephrine every 3–5 min during cardiac arrest. The optimal dose of epinephrine is not known. We evaluated the association of reduced frequency and dose of epinephrine with survival after out-of-hospital cardiac arrest (OHCA). Methods Included were patients with non-traumatic OHCA treated by advanced life support (ALS) providers from January 1, 2008 to June 30, 2016. During the before period, providers were instructed to give epinephrine 1 mg intravenously at 4 min followed by additional 1 mg doses every eight minutes to patients with OHCA with a shockable rhythm and 1 mg doses every two minutes to patients with a non-shockable rhythm (higher dose). On October 1, 2012, providers were instructed to reduce the dose of epinephrine treatment during out-of-hospital cardiac arrest (OHCA): 0.5 mg at 4 and 8 min followed by additional doses of 0.5 mg every 8 min for shockable rhythms and 0.5 mg every 2 min for non-shockable rhythms (lower dose). Patients with shockable initial rhythms were analyzed separately from those with non-shockable initial rhythms. The primary outcome was survival to hospital discharge with a secondary outcome of favorable neurological status (Cerebral Performance Category [CPC] 1 or 2) at hospital discharge. Multiple logistic regression modeling was used to adjust for age, sex, presence of a witness, bystander CPR, and response interval. Results 2255 patients with OHCA were eligible for analysis. Of these, 24.6% had an initially shockable rhythm. Total epinephrine dose per patient decreased from a mean ± standard deviation of 3.4 ± 2.3 mg–2.6 ± 1.9 mg (p Conclusion Reducing the dose of epinephrine administered during out-of-hospital cardiac arrest was not associated with a change in survival to hospital discharge or favorable neurological outcomes after OHCA.
Evidence for the Coordination–Insertion Mechanism of Ethene Dimerization at Nickel Cations Exchanged onto Beta Molecular Sieves

The mechanistic origin of alkene dimerization on Ni sites supported on aluminosilicates has been ascribed to both coordination–insertion (i.e., Cossee-Arlman) and metallacycle-based cycles; the latter is often invoked in the absence of externally supplied cocatalysts or activators that generate Ni-hydride or Ni-alkyl species to initiate coordination–insertion cycles. Determining the prevalent reaction mechanism at Ni sites is often complicated by the formation and consumption of alkene dimer products via oligomerization and other parallel reactions (e.g., cracking, isomerization) that occur at Bronsted acid sites on supports. Here, ethene dimerization (453 K) was studied on Beta zeolites synthesized to contain predominantly exchanged Ni2+ sites according to site balances determined by cation exchange, and to Ni structure determined by CO infrared, UV–visible, and Ni K-edge X-ray absorption spectroscopies. The catalytic behavior of Ni2+ sites was isolated by suppressing contributions from residual H+ sites...
Transient complete heart block following catheter ablation of a left lateral accessory pathway

A 16-year-old female with symptomatic Wolff-Parkinson-White (WPW) syndrome underwent catheter ablation of a left-sided lateral accessory pathway. The accessory pathway was eliminated with the first ablation lesion; however, the patient immediately developed complete heart block (CHB). At first, complete heart block was thought to be due to ablation of left atrial extension of the AV node, and pacemaker therapy was considered. However, careful ECG analysis revealed that the development of CHB was in fact due to bump injury to the AV node during transseptal catheterization. Conservative management allowed resolution of AV nodal conduction without need for a permanent pacemaker.
Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate

Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and regenerative medicine due to their self-renewal and differentiation capacities. The majority of current PSC protocols rely on 2D cultures and soluble factors to guide differentiation; however, many other environmental signals are beginning to be explored using biomaterial platforms. Biomaterials offer new opportunities to engineer the stem cell niches and 3D environments for exploring biophysical and immobilized signaling cues to further our control over stem cell fate. Here, we review the biomaterial platforms that have been engineered to control PSC fate. We explore how altering immobilized biochemical cues and biophysical cues such as dimensionality, stiffness, and topography can enhance our control over stem cell fates. Finally, we highlight biomaterial culture systems that assist in the translation of PSC technologies for clinical applications.
Serum and urinary metabolomics and outcomes in cirrhosis

Background Cirrhosis can alter several metabolic pathways. Metabolomics could prognosticate outcomes like hepatic encephalopathy (HE), transplant, hospitalization and death. Aim Determine changes in serum and urine metabolomics in cirrhotics who develop outcomes. Methods Cirrhotic outpatients underwent data, serum/urine collection and were followed for 90 days. Demographics, cirrhosis details and medications were collected. Metabolomics was performed on urine/serum using GC/MS with subsequent bioinformatics analyses (ChemRICH, MetaMAPP and PLS-DA). Logistic regression adjusting for covariates (demographics, alcohol etiology, prior HE, PPI, SBP prophylaxis, rifaximin/lactulose) were performed and ROC curves comparing MELD to adjusted serum & urine metabolites were created. Results 211 patients gave serum, of which 64 were hospitalized, 19 developed HE, 13 were transplanted and 11 died. 164 patients gave urine of which 56 were hospitalized, 18 developed HE, 12 were transplanted and 11 died. Metabolomics: Saturated fatty acids, amino acids and bioenergetics-related metabolites differentiated patients with/without outcomes. After regression, 232, 228, 284 and 229 serum metabolites were significant for hospitalization, HE, death and transplant. In urine 290, 284, 227 & 285 metabolites were significant for hospitalization, HE, death and transplant respectively. AUC was higher for serum metabolites vs MELD for HE (0.85 vs.0.76), death (0.99 vs.0.88), transplant (0.975 vs.0.94) and hospitalizations (0.84 vs.0.83). Similarly, urinary metabolite AUC was also higher than MELD for HE (0.87 vs.0.72), death (0.92 vs 0.86), transplant (0.99 vs.0.90) and hospitalizations (0.89 vs.0.84). Conclusions In this exploratory study, serum and metabolites focused on lipid, bioenergetics and amino acid metabolism are altered in cirrhotics who develop negative outcomes.
ADAM proteases: Emerging role and targeting of the non-catalytic domains.

Abstract ADAM proteases are multi domain transmembrane metalloproteases that cleave a range of cell surface proteins and activate signaling pathways implicated in tumor progression, including those mediated by Notch, EFGR, and the Eph receptors. Consequently, they have emerged as key therapeutic targets in the efforts to inhibit tumor initiation and progression. To that end, two main approaches have been taken to develop ADAM antagonists: (i) small molecule inhibitors, and (ii) monoclonal antibodies. In this mini-review we describe the distinct features of ADAM proteases, particularly of ADAM10 and ADAM17, their domain organization, conformational rearrangements, regulation, as well as their emerging importance as therapeutic targets in cancer. Further, we highlight an anti-ADAM10 monoclonal antibody that we have recently developed, which has shown significant promise in inhibiting Notch signaling and deterring growth of solid tumors in pre-clinical settings.
Implementation of the Psychosocial Standards for Caregiver Mental Health Within a Pediatric Hematology/Oncology Program.

The assessment of mental health needs and access to appropriate interventions for parents and caregivers is one of 15 evidence-based standards for the psychosocial care of children with cancer and their families. The objectives of this paper are to describe one program's approach to meeting this standard in oncologic, hematologic, and immunologic populations and outline key ethical, regulatory, and logistical considerations in providing mental health services to caregivers in a pediatric medical setting. A description of the Caregiver Mental Health Program (CMHP) is provided along with a case example to illustrate key considerations, including multiple family members needing care, access to psychiatric services, scope of treatment, confidentiality and privacy, and logistics. Challenges in the development of the CMHP as well as the program’s benefits are discussed. Implementation of this standard of care will vary across institutions depending on various factors, such as staffing and programmatic resources and institutional culture.
Do You Get What You Pay for? Salary and Ex Ante Player Value in Major League Baseball:

The last few years have seen a resurgence of very long, very expensive guaranteed contracts in Major League Baseball. Commentators who examine the outcomes of earlier long-term contracts generally ...
Interrupt to Activate-Transform Passive Video Watching into Engaged Active Learning

Recorded lectures have rapidly gained momentum in teaching and learning, whether online or “offline” in traditional face-to-face classrooms. We appreciate the remarkable accessibility and flexibili...
The Role of Innovation and Intellectual Capital in Improving Company Performance

Innovation and intellectual capital are essential factors that companies must pay attention to in maintaining their performance and business sustainability. Innovation decisions and investments intellectual capital require support from the owners to improve the company's performance. This study aims to analyze the innovation decisions studied through two strategies: demand-pull and technology push, and the role of intellectual capital in improving company performance, and moderated by family ownership. In this study, the demand-pull and technology push strategy is measured by looking at new product launches and purchases of new equipment by companies for a certain period. Intellectual capital is calculated by using the Value-Added Intellectual Coefficient (VAIC), then Return on Asset (ROA) to measure the company's performance. The subjects of this study were twenty-six (26) companies with family ownership engaged in consumer goods sectors and listed on the Indonesia Stock Exchange (IDX) in the 2015-2019 period. The data used were 130 including 30 data from the study were outliers. This study uses multiple linear regression moderation. The test results show that the innovation factors, namely demand-pull and technology push, and intellectual capital, positively influence company performance. However, family ownership weakens the influence of both innovation factors and can’t moderate the effect of intellectual capital on performance.
Audio description for 3-Dimensional (3D) virtual worlds

Three-dimensional (3D) virtual worlds have little to offer people with visual disabilities because the experience is largely visual in nature. This paper describes a project that seeks to develop best practices for creating audio description for 3D virtual worlds by creating and testing audio descriptions for the University of Hawaiʻi at Manoa College of Education’s OpenSim virtual campus as a proof of concept.
High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: a report from the Children's Oncology Group.

Background Body mass index (BMI), at diagnosis has been associated with lower survival and increased toxicity in cancer patients. We analyzed the effect of BMI at diagnosis on therapy related toxicities and outcome in pediatric osteosarcoma patients treated on Children's Oncology Group (COG) trial INT0133. Procedures All patients enrolled on COG-INT0133 with height, weight and toxicity information were eligible. BMI was expressed as age and gender specific percentiles using height and weight at diagnosis. Patients were classified into high, normal and low BMI groups. Logistic regression models were used to analyze toxicities; Kaplan–Meier curves were created to assess event free (EFS) and overall survival (OAS). Results Seven hundred and ten patients met eligibility criteria. BMI distribution was: 447 normal BMI, 74 low BMI, and 189 high BMI. Renal toxicity was higher in the high BMI group (OR = 2.7, 95% CI 1.2–6.4, P = 0.01) only during one of the courses of therapy. Compared to the normal BMI group, patients with high BMI had significantly worse OAS at 5 years compared to those with normal BMI, 69.7% versus 80.5% (HR = 1.6, 95% CI 1.1–2.2, P = 0.005) and a trend towards worse event-free survival at 3 years 66.2% versus 75.5% (HR = 1.3 95% CI 0.9–1.8, P = 0.05). There was no difference in EFS or OAS in patients with low BMI compared to patients with normal BMI. Conclusions High BMI at diagnosis is associated with worse OAS in patients with osteosarcoma. No clinically significant differences in toxicity were observed in the various BMI groups. Pediatr Blood Cancer 2013;60:2042–2046. © 2013 Wiley Periodicals, Inc.
REGULATING THE ATHLETE-AGENT INDUSTRY: INTENDED AND UNINTENDED CONSEQUENCES

Concerns involving sports agents tend to fall within two broad categories - issues involving professional competence and ethics on the one hand, and issues involving overzealous competition for clients and recruiting improprieties on the other. Salient illustrations of agent malfeasance and ethical compromises include income mismanagement, missing deadlines in player contracts, and engaging in conduct that conflicts with the interests of their athlete clients. Factors that contribute to the intense competition that breeds conflict amongst agents include the significant fees that are potentially available if an agent signs an athletes, the increase in the number of agents between the 1960s and 1990s, and the relatively stable pool of potential athlete-clients. Competition for clients manifests in client stealing, agents disparaging the reputations of other agents, and improper recruitment tactics by agents such as giving financial inducements to athletes to sign representation agreements. The harm inflicted upon athletes as a result of such conduct underscores the need for effective means of regulating the athlete-agent industry. After detailing illustrations of agent misconduct and the consequences thereof, the article examines indirect means used to regulate and hold athlete agents accountable such as civil and criminal lawsuits, ethical and professional standards governing attorneys, and NCAA rules and regulations. It also critically analyzes direct regulatory mechanisms, including state and federal legislation, and player association regulations. Arguing that past efforts have been largely unsuccessful in effectively regulating the athlete-agent industry, the article proposes a multi-layered regulatory approach. In this regard, the article concludes that recent changes to the National Football Players Association's agent regulatory system when combined with state and federal legislation, and common law concepts hold promise for ameliorating problems in the athlete-agent industry.
compPknots: a framework for parallel prediction and comparison of RNA secondary structures with pseudoknots

Codes for RNA secondary structure prediction based on energy minimization are usually time and resource intensive. For this reason several codes have been simplified: in some cases they do not predict complex structures like pseudoknots, other times they predict structures with reduced lengths, or with simple pseudoknots. Each of these codes has its strengths and weaknesses. Providing scientists with tools that combine the strengths of the several codes is a worthwhile objective. To address this need, we present compPknots, a parallel framework that uses a combination of existing codes like Pknots-RE and Pknots-RG, to predict RNA secondary structures concurrently and automatically compare them with reference structures from databases or literature. In this paper compPknots is used to compare the predictions of 217 RNA structures from the PseudoBase database. Its parallel master-slave architecture provide scientists with higher prediction accuracies in shorter time.
The Death of the American Trial

In "The Death of the American Trial", distinguished legal scholar Robert P. Burns makes an impassioned case for reversing the rapid decline of the trial before we lose one of our public culture's greatest achievements. As a practice that is adapted for modern times yet rooted in ancient wisdom, the trial is uniquely suited to balance the tensions - between idealism and realism, experts and citizens, contextual judgment and reliance on rules - that define American culture. Arguing that many observers make a grave mistake by taking a complacent or even positive view of the trial's demise, Burns concludes by laying out the catastrophic consequences of losing an institution that so perfectly embodies democratic governance.
Overexpression of the wild type p73 gene in breast cancer tissues and cell lines.

The p73 gene is a structural and, in overexpression systems, functional p53 homologue. Ectopic p73 expression can activate a broad subset of p53 -responsive genes, induce apoptosis, and act as a growth suppressor. Yet, viral oncoproteins that antagonize p53 (adenovirus E1B 55K, SV40 large T, and human papillomavirus E6) do not antagonize p73. This could suggest that inactivation of p73, in contrast to p53, is not required for tumorigenesis. Also, p73 is not activated by DNA damage. Because intragenic p73 mutations in tumors have not been reported and imprinting is idiosyncratic, tumor-specific changes in wild-type p73 expression levels become the most reliable guide toward identifying the normal function of p73 and its role in tumorigenesis. We analyzed 77 invasive breast cancers and 7 breast cancer cell lines for p73 mRNA expression levels, allelic origin, intragenic mutations, and COOH-terminal splice variants. A range of normal tissues, including breast, showed very low p73 expression, with little variation from tissue to tissue. In contrast, 38% (29 cases) of breast cancers had elevated p73 mRNA ranging from 5–25-fold above normal, with the remaining tumors (64%) falling within the normal range. Moreover, five of seven cell lines (71%) also exhibited p73 overexpression (13–73-fold). Yet, no correlation with p21 mRNA and protein levels was present, although four of the five lines were mutant for p53. Mutation analysis of the eight highest expressers showed wild type status. Eight of 14 informative samples were biallelic, whereas the remaining 6 samples showed monoallelic expression. Tumors and cell lines with p73 overexpression tended to exhibit a complex profile of up to six different COOH-terminal splice variants, whereas normal and transformed tissues with low p73 mRNA predominantly expressed p73 α. We confirm the previously described variants p73 γ and δ in breast tissue and describe two novel isoforms, p73 e and φ, thereby further enlarging combinatorial possibilities. Together, our in vivo data show that p73 does not have a role as a classic Knudson-type tumor suppressor in breast cancer.
THE EFFECTS OF RACIAL SELF-IDENTITY ON COLLEGE GPA AND STUDENT SATISFACTION AT VERY SELECTIVE COLLEGES AND UNIVERSITIES

DuBois (2007) began a broad and rich tradition of investigating multi-racial identities and interracial relations. Today, much of the empirical research on race takes place at the level of higher education. Racial identities and racial friendship networks in college have been investigated by many researchers. Several researchers have found that interracial interactions positively affect cognitive outcomes and college satisfaction for all students. Yet, studies that have explored the relationship between the attitudes of minority students and educational outcomes have mixed findings. Using data from the National Longitudinal Survey of Freshmen, this study examines how minority students’ racial self-identity affects college cumulative GPA and various measures of college satisfaction and whether the effects of self-identity (attitudes) are separate from those of interracial friendship circles (behaviors). Results of this study show that, for Black and Hispanic students, embracing a racial-group identity (Black or Hispanic) or a compound identity (Black-American or Hispanic-American) over identifying primarily as an American does not affect college GPA but does negatively impact some measures of college satisfaction; furthermore, the effects of self-identity are separate from the consequences of having few interracial friendships. Finally, racial identity did not significantly affect Asian student satisfaction or GPA.
Denominational Support for Clergy Mental Health

To date, minimal research has addressed the actual services provided to maintain the mental health of leadership in the church. Three major Protestant denominations were consulted with in this stud...
Initial Boundary-Value Problems for Soliton Equations

A method is presented for linearizing initial-boundary value problems for integrable nonlinear evolution equations with the spatial variable on an half-infinite line. This method yields the solution of a nonlinear equation in terms of the solution of two linear integral equations, whose analysis for large t, shows how the boundary conditions can generate solitons.
Using NOAA/AVHRR based remote sensing data and PCR method for estimation of Aus rice yield in Bangladesh

Rice is a dominant food crop of Bangladesh accounting about 75 percent of agricultural land use for rice cultivation and currently Bangladesh is the world’s fourth largest rice producing country. Rice provides about two-third of total calorie supply and about one-half of the agricultural GDP and one-sixth of the national income in Bangladesh. Aus is one of the main rice varieties in Bangladesh. Crop production, especially rice, the main food staple, is the most susceptible to climate change and variability. Any change in climate will, thus, increase uncertainty regarding rice production as climate is major cause year-to-year variability in rice productivity. This paper shows the application of remote sensing data for estimating Aus rice yield in Bangladesh using official statistics of rice yield with real time acquired satellite data from Advanced Very High Resolution Radiometer (AVHRR) sensor and Principal Component Regression (PCR) method was used to construct a model. The simulated result was compared with official agricultural statistics showing that the error of estimation of Aus rice yield was less than 10%. Remote sensing, therefore, is a valuable tool for estimating crop yields well in advance of harvest, and at a low cost.
Prediction of specific heat of cereal flours: A quantitative empirical correlation

Abstract Thermograms of wheat, corn and rice flour samples were recorded using pressure variable DSC. Pressure was maintained at 20 atm during measurements, and thermograms were normalized to yield specific heat curves as a function of temperature, moisture content and protein content. Specific heat data were fitted to a general empirical equation, using an algorithm for multiple regression with subsequent statistical analysis. A quantitative empirical equation incorporating temperature, moisture content, and protein content dependent terms was developed to predict specific heat of cereal flours and starches between 20 and 110 °C and the moisture content between 0% and 70% dry basis. Proposed equation predicts the specific heat of flours in the database with an average absolute error of 2.3% and the specific heat of cereal flours and starches reported in the literature with an average absolute error of 4.3%.
Acquiring taxonomic relations in lexical memory: The role of superordinate category labels☆

Abstract Two experiments tested predictions based on Nelson's (e.g., Nelson, 1985 ; Lucariello & Nelson, 1985 ) theory of taxonomic development. In Nelson's view, children relate slot-fillers (e.g., cereal - egg) in memory because they are substitutable within the same scripts. Coordinates (e.g., cereal - hamburger), members of the same superordinate category that are part of different scripts, are related through knowledge of a shared superordinate label (e.g., food). In these experiments, we tested whether knowledge of a superordinate label is associated with stronger relations between coordinates but not between slot-fillers. In Experiment 1, preschoolers' reaction times were measured during a triad sorting task. Matching picture pairs within the triads were either slot-filler familiar (slot-fillers with a familiar superordinate label), slot-filler unfamiliar (slot-fillers with an unfamiliar superordinate label), coordinate familiar, or coordinate unfamiliar. In Experiment 2, subjects were given a cued recall task. Lists consisted of either slot-filler or coordinate word pairs. Half the word pairs had familiar superordinate labels and half had unfamiliar labels. In both studies, superordinate label familiarity had no effects, although children's performance was better on slot-filler pairs overall. Because these results do not support Nelson's theory, we propose an alternative account of taxonomic development.
Perceptions of fairness in the division of responsibility for old parents

Pairs of sisters in 50 families in which at least one parent was aged 75+ were asked in open-ended questions to describe the division of filial responsibility in their families and their feelings about it. The relationship between the quality of ties among siblings and evaluations of the fairness of the division of responsibility is explored. The argument is made that rules of distributive justice are invoked largely within the context of the projected futures of existing relationships.