cssi/SciSciGPT-SciSciNet huggingface dataset:
Membrane-bound Progesterone Receptor Expression in Human Aortic Endothelial Cells:

Observational studies demonstrate that estradiol and progesterone affect vasoreactivity. In animal studies, progesterone treatment causes immediate relaxation of precontracted arteries with inhibition of calcium influx in vascular endothelial and smooth muscle cells, suggesting a non-genomic mechanism of action. In this study we investigated the presence of novel membrane-bound progesterone receptors in human aortic endothelial cells and correlated the expression with cell-cycle stage. Western blotting analysis with an antibody directed to the hormone-binding domain of the classic progesterone receptors shows predominant bands at 100 and 60 kD, whereas analysis with an antibody to the DNA-binding region shows only the 100-kD band. In contrast, classic nuclear progesterone receptors B and A are identified at 116 and 94 kD in similarly processed T47D cells. Both novel bands localize to the membrane fraction after differential centrifugation. Plasma membrane-bound progesterone receptor was further shown with immunofluorescent antibody and ligand-binding studies in a small percentage of human aortic endothelial cells. Fluorescent activated cell sorting demonstrated that approximately 8% of the human aortic endothelial cells expressed a plasma membrane progesterone receptor and that a greater percentage of the expressing cells were in the G2/M-phase of the cell cycle. Treatment with progesterone conjugated to BSA did not show any significant cell-cycle changes. Plasma membrane-bound progesterone receptor in vascular endothelial cells may regulate the non-genomic actions of progesterone, and expression of the receptor appears to vary with cell cycle stage.
Beer and the business cycle

The beer industry has traditionally been viewed as ‘recession-proof’: drinkers will have their beer notwithstanding the ecomomy's ups and downs. Few empirical studies have examined the veracity of the claim of beer's non-cyclicality and none have used monthly data. This paper uses an error–correction specification to test the sensitivity o mfonthly beer consumption to cyclical macro-economic variables over the period January 1955–December 1994. Strong support was found for the traditional view: beer is mostly immune to economic cycles.
Citigroup's Exchange Offer (B)

Citigroup faced considerable distress in early 2009. In late 2008, the bank had accepted $45 billion in preferred equity from the United States government via the Troubled Assets Relief Program (TARP). Yet, the stock had continued to slide in early 2009. In late February, the company announced that it would convert as much as $50 billion of preferred stock into common stock, at $3.25 per share. The case asks students to evaluate the pricing of preferred stock relative to common stock at this time. As the case takes place during a period of considerable uncertainty in global capital markets, and conventional sources of arbitrage capital have been depleted, the apparent mispricing may not be as attractive as it initially seems. In the B and C case, students must decide whether their view of the appropriate pricing changes, when the apparent mispricing worsens. A final additional teaching point relates to the formation of a synthetic short position using the options markets.
Relative Resistance of Long Junctional Epithelial Adhesions and Connective Tissue Attachments to Plaque-Induced Inflammation*

This study compared the resistance to periodontal disease of the long junctional epithelial adhesion and the naturally occurring dentogingival junction. Two groups were used, each containing three young male beagle dogs with all permanent teeth erupted. Periodontitis was induced around maxillary and mandibular premolars in the experimental dogs over a 42-day period, using subgingival ligatures and a soft diet. Fourteen days after ligature removal, flaps were reflected, granulation tissue was removed and the roots were planed to the alveolar crest. Reference grooves were placed in the root surfaces at the level of the alveolar bone, the flaps were positioned over the alveolar crests, and sutures were placed. A 60-day period permitted healing with formation of long junctional epithelial adhesions. During this 116-day period control dogs were maintained in gingival health by daily brushing and by prophylaxis every 14 days. Both groups had a high level of health (GI scores of 0) at the beginning of the 20-day combined disease phase. Inflammation was induced in both groups by subgingival ligature placement and a plaque-promoting diet. Right and left sides of both groups represented separate time intervals within the 20-day period. Block sections were secured at time of killing and the tissues were prepared for light and fluorescent microscopic evaluation. Mean GI scores and mean probing depths increased similarly in both groups. Tagge index scores of gingival inflammation were higher at the longer time periods in the experimental animals. However, they displayed an intact long junctional epithelial adhesion throughout the study, while control animals frequently showed ulceration of the sulcular epithelium. Neither group showed significant changes in location of the apical cells of the attachment epithelium. Crestal osteoblastic activity, confirmed with Procion labeling, predominated in the experimental animals, while osteoclastic activity predominated in the control. Under the conditions of this study, there appeared to be no appreciable difference in resistance to disease between a long junctional epithelial adhesion and a true connective tissue attachment.
A parametric version of jackknife-after-bootstrap

We investigate the problem of deriving precision estimates for bootstrap quantities within parametric families. B. Efron's (1992) jackknife-after-bootstrap is a simple approach that only uses the information in the original bootstrap samples via the importance sampling technique, with no further resampling required. This method can be applied to many Monte Carlo experiments, especially, to the parametric input modeling problems. Variance analysis of the parametric jackknife-after-bootstrap is discussed. Under some reasonable conditions, the parametric jackknife-after-bootstrap method is as good as the true jackknife method. A generalized parametric jackknife-after-bootstrap method is introduced.
The Impact of Subclinical Disease and Mechanism of Detection on the Rise in Thyroid Cancer Incidence: A Population-Based Study in Olmsted County, Minnesota During 1935 Through 2012.

Background: An ongoing epidemic of thyroid carcinoma (TC) has affected Americans since 1975. Understanding the contribution of subclinical disease and the mechanism of such disease detection may he...
Picking up the Pieces: Self-Healing in reconfigurable networks

We consider the problem of self-healing in networks that are reconfigurable in the sense that they can change their topology during an attack. Our goal is to maintain connectivity in these networks, even in the presence of repeated adversarial node deletion, by carefully adding edges after each attack. We present a new algorithm, DASH, that provably ensures that: 1) the network stays connected even if an adversary deletes up to all nodes in the network; and 2) no node ever increases its degree by more than 2 log n, where n is the number of nodes initially in the network. DASH is fully distributed; adds new edges only among neighbors of deleted nodes; and has average latency and bandwidth costs that are at most logarithmic in n. DASH has these properties irrespective of the topology of the initial network, and is thus orthogonal and complementary to traditional topology- based approaches to defending against attack. We also prove lower-bounds showing that DASH is asymptotically optimal in terms of minimizing maximum degree increase over multiple attacks. Finally, we present empirical results on power-law graphs that show that DASH performs well in practice, and that it significantly outperforms naive algorithms in reducing maximum degree increase.
Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation

Injectable and implantable porosified silicon (pSi) carriers and devices for prolonged and controlled delivery of biotherapeutics offer great promise for treatment of various chronic ailments and acute conditions. Polyethylene glycols (PEGs) are important surface modifiers currently used in clinic mostly to avoid uptake of particulates by reticulo-endothelial system (RES). In this work we show for the first time that covalent attachment of PEGs to the pSi surface can be used as a means to tune degradation kinetics of silicon structures. Seven PEGs with varying molecular weights (245, 333, 509, 686, 1214, 3400, and 5000 Da) were employed and the degradation of PEGylated pSi hemispherical microparticles in simulated physiological conditions was monitored by means of ICP-AES, SEM, and fluorimetry. Biocompatibility of the systems with human macrophages in vitro was also evaluated. The results clearly indicate that controlled PEGylation of silicon microparticles can offer a sensitive tool to finely tune their degradation kinetics and that the systems do not induce release of proinflammatory cytokines IL-6 and IL-8 in THP1 human macrophages.
What Is the Relationship Between Emotional Intelligence and Dental Student Clinical Performance

Emotional intelligence has emerged as a key factor in differentiating average from outstanding performers in managerial and leadership positions across multiple business settings, but relatively few studies have examined the role of emotional intelligence in the health care professions. The purpose of this study was to examine the relationship between emotional intelligence (EI) and dental student clinical performance. All third- and fourth-year students at a single U.S. dental school were invited to participate. Participation rate was 74 percent (100/136). Dental students’ EI was assessed using the Emotional Competence Inventory-University version (ECI-U), a seventy-two-item, 360-degree questionnaire completed by both self and other raters. The ECI-U measured twenty-two EI competencies grouped into four clusters (Self-Awareness, Self-Management, Social Awareness, and Relationship Management). Clinical performance was assessed using the mean grade assigned by clinical preceptors. This grade represents an overall assessment of a student’s clinical performance including diagnostic and treatment planning skills, time utilization, preparation and organization, fundamental knowledge, technical skills, self-evaluation, professionalism, and patient management. Additional variables were didactic grade point average (GPA) in Years 1 and 2, preclinical GPA in Years 1 and 2, Dental Admission Test academic average and Perceptual Ability Test scores, year of study, age, and gender. Multiple linear regression analyses were conducted. The Self-Management cluster of competencies (b=0.448, p
Synthesis of Cul-De-Sac Filter Networks Utilizing Hybrid Couplers

A synthesis procedure is described for the design of Cul-De-Sac networks realizing either bandpass or bandstop filter characteristics. The prototypes comprise a pair of one-port ladder sub-networks each connected at one of the coupled ports of a 3-dB, 90deg or 180deg hybrid coupler. Numerical examples and simulated filter layouts are presented to illustrate the design methodology
Long-wavelength infrared stimulation of luminescence in ZnS

Luminescent effects due to infrared stimulation have been investigated in an undoped ZnS crystal and various ZnS phosphor powders. Many varieties of infrared stimulation spectra are observed in the 1.3 to 10 μm spectral range including narrow lines and broad band responses. Narrow line positions are found to depend on phosphor composition. The spacing between these lines is much closer than the LO and TO phonon energies of ZnS. A smooth shift of the narrow line positions toward lower energies and continuous increase of line widths are measured with increasing temperature. The narrow line spectra have several features that suggest a transition from the ground state to an excited state of an impurity or defect rather than direct excitation of a bound electron (hole) to conduction (valence) band. The response of ZnS phosphors is also examined for 300 K thermal sources and it appears that ZnS can be used for passive IR imaging. Es wird die durch Infrarotstimulation hervorgerufene Lumineszenz in einem undotierten ZnS-Einkristall und verschiedenen ZnS-Pulverphosphoren untersucht. Eine Reihe verschiedener Infrarotstimulations-Spektren werden im Spektralbereich von 1,3 bis 10 μm beobachtet, einschlieslich schmaler Linien und breitbandiger Response. Die Lagen der schmalen Linien hangen von der Zusammensetzung der Phosphore ab. Der Abstand zwischen diesen Linien ist viel enger als die LO- und TO-Phononenenergie in ZnS. Es wird eine gleichmasige Verschiebung der Lagen der schmalen Linien zu niedrigen Energien und ein kontinuierliches Anwachsen der Linienbreite mit wachsender Temperatur gemessen. Die schmallinigen Spektren zeigen einige Einzelheiten, die eher auf einen Ubergang aus dem Grundzustand in einen angeregten Zustand einer Fremd- oder Eigenstorstelle, als auf eine direkte Anregung eines gebundenen Elektrons (Lochs) zum Leitungs(Valenz)band hindeuten. Die Response von ZnS-Phosphoren wird auch fur thermische Strahler von 300 K untersucht, und es scheint, das man ZnS als abbildendes System benutzen kann.
A 77GHz monolithic IMPATT transmitter in standard CMOS technology

In this paper, a fully integrated transmitter at 77GHz is presented in a 0.18/spl mu/m standard CMOS technology. The system consists of a lateral IMPATT diode and a microstrip patch antenna. The antenna impedance seen by the IMPATT diode is optimized using the high frequency electromagnetic (EM) field solver, Sonnet, which is matched to the measured impedance of the diode. The transmitted power had an offset frequency of -0.13% from the simulation results.
Should your MOOC forum use a reputation system

Massive open online courses (MOOCs) rely primarily on discussion forums for interaction among students. We investigate how forum design affects student activity and learning outcomes through a field experiment with 1101 participants on the edX platform. We introduce a reputation system, which gives students points for making useful posts. We show that, as in other settings, use of forums in MOOCs is correlated with better grades and higher retention. Reputation systems additionally produce faster response times and larger numbers of responses per post, as well as differences in how students ask questions. However, reputation systems have no significant impact on grades, retention, or the students' subjective sense of community. This suggests that forums are essential for MOOCs, and reputation systems can improve the forum experience, but other techniques are needed to improve student outcomes and community formation. We also contribute a set of guidelines for running field experiments on MOOCs.
THE EFFECT OF MULTIPLE SΔ PERIODS ON RESPONDING ON A FIXED‐INTERVAL SCHEDULE1

The effect of repeated interruption of FI responding by short SΔ presentations on the pattern of increasing frequency of responding through the interval has been studied. Although the SΔ profoundly changed the pattern of responding during their presentation, the general scalloped pattern of FI responding survived. The implication of these findings for understanding the role of chaining of responses in FI patterns is discussed. It is suggested that chaining is not a necessary condition for the scalloped pattern.
Scute Anomalies of Ornate Box Turtles in Kansas

Abstract Deviations from the normal scute formulae of turtles are thought to result from embryonic mutations, the specific causes of which are unknown. We examined the shells of 127 ornate box turtles (Terrapene ornata) from central and eastern Kansas; 14 (11%) of which had scute anomalies. The frequency of anomalies was greater in central than eastern Kansas. The greater number of scute anomalies in central Kansas may be the result of temperature or moisture stress during egg development or incubation, or the mutagenic effects of excess salinity during those periods.
A Hybrid Predistorter for Nonlinearly Amplified MQAM Signals

This paper proposes an adaptive baseband Predistortion scheme in order to reduce both nonlinear amplitude and phase distortion introduced by a travelling wave tube amplifier (TWTA) over transmitted 16QAM and 256QAM signals. This compensator is based on a radial basis function neural network (RBF NN) and its coefficients are estimated by using a hybrid algorithm, namely generalised inverse and gradient descent. Computer simulation results confirm that once the 16QAM and 256QAM signals are predistortioned and amplified at an input back off level of 0 dB, there is a reduction of 25 dB and 29 dB spectrum re-growth; respectively. In addition proposed adaptive Predistortion scheme has a low complexity and fast convergence.
Differential treatment response, neuroinflammation, and psychosis associated with chromosome deletion.

Dr. Hollander is the editor of this journal, Esther and Joseph Klingenstein Professor and Chairman of Psychiatry at the Mount Sinai School of Medicine, and director of the Seaver and New York Autism Center of Excellence in New York City. There is substantial evidence that obsessivecompulsive disorder (OCD) symptoms can be grouped into a series of discrete dimensions, and some evidence that not all OCD symptom dimensions respond equally well to treatment interventions. The response of OCD symptom dimensions to 12 weeks of treatment with escitalopram/placebo, was investigated by Dan J. Stein, MD, PhD, and colleagues. Factor analysis of individual Yale-Brown Obsessive-Compulsive Scale items yielded 5 factors (contamination/cleaning, harm/ checking, hoarding/symmetry, religious/sexual, and somatic/hypochondriacal). While escitalopram exhibited good efficacy across the range of OCD symptom dimensions, hoarding/symmetry was associated with a poorer treatment response. Hoarding/symmetry may be particularly characteristic of an early-onset group of OCD patients, with the involvement of neurotransmitters other than serotonin. Further work is needed to fully delineate the subtypes of OCD, and their correlates with underlying psychobiology and treatment responsivity. A greater understanding of subfactors within various symptom domains may eventually lead to greater understanding of differential treatment outcomes. Multiple lines of evidence suggest that inflammation and glutamate dysfunction contribute to the pathophysiology of depression. Jonas Hannestad, MD, PhD, and colleagues reviewed how these two systems may interact. Excess levels of inflammatory mediators occur in a subgroup of depressed patients. Acute experimental activation of the immune system with endotoxin and of chronic activation during interferon-α treatment show that inflammation can cause depression. Peripheral inflammation leads to microglial activation, which could interfere with excitatory amino acid metabolism, leading to inappropriate glutamate receptor activation. Loss of astroglia, a feature of depression, upsets the balance of antiand pro-inflammatory mediators and further impairs the removal of excitatory amino acids. Microglia activated by excess inflammation, astroglial loss, and inappropriate glutamate receptor activation may ultimately disrupt the delicate balance of neuroprotective versus neurotoxic effects in the brain, potentially leading to depression. Thus, psychiatric disorders, such as depression, may benefit from a greater understanding of the role of inflammation in its pathophysiology. Medical specialties, such as rheumatology, have benefited from greatly expanded treatment options for inflammation in recently. Varenicline has demonstrated efficacy in the promotion of smoking cessation. However, from the time of initial trials, it has been associated with significant psychiatric adverse effects. Andres J. Pumariega, MD, and colleagues describe a case where mixed mood and psychotic disturEditor’s Letter
Improving the interface performance of synthesized structural FAME simulators through scheduling

Computer designers rely upon near-cycle-accurate microarchitectural simulators to explore the design space of new systems. Hybrid simulators which offload simulation work onto FPGAs (also known as FAME simulators) can overcome the speed limitations of software-only simulators. However such simulators must be automatically synthesized or the time to design them becomes prohibitive. Previous work has shown that synthesized simulators should use a latency-insensitive design style in the hardware and a concurrent interface with the software. We show that the performance of the interface in such a simulator can be improved significantly by scheduling all communication between hardware and software. Scheduling reduces the amount of hardware/software communication and reduces software overhead. Scheduling is made possible by exploiting the properties of the latency-insensitive design technique recommended in previous work. We observe speedups of up to 1.54 versus the former interface for a multi-core simulator.
Forsterite [Mg2SiO4)] carbonation in wet supercritical CO2: an in situ high-pressure X-ray diffraction study.

Mechanisms controlling mineral stabilities in contact with injected supercritical fluids containing water are relatively unknown. In this paper, we discuss carbonation reactions occurring with forsterite (Mg2SiO4) exposed to variably wet supercritical CO2 (scCO2). Transformation reactions were tracked by in situ high-pressure X-ray diffraction in the presence of scCO2 containing dissolved water. Under modest pressures (90 bar) and temperatures (50 °C), scCO2 saturated with water converted >70 wt % forsterite to a hydrated magnesium carbonate, nesquehonite (MgCO3·3H2O), and magnesite (MgCO3) after 72 h. However, comparable tests with scCO2 at only partial water saturation showed a faster carbonation rate but significantly less nesquehonite formation and no evidence of the anhydrous form (MgCO3). The presence and properties of a thin water film, observed by in situ infrared (IR) spectroscopy and with isotopically labeled oxygen (18O), appears to be critical for this silicate mineral to carbonate in low wate...
Prader-Willi Syndrome and Atonic Seizures

A 2.5-year-old boy with Prader-Willi syndrome and a history of neonatal superior sagittal sinus thrombosis developed a febrile seizure and new onset atonic drop seizures originating in the parasagittal region, as reported from Children’s Hospital, Boston.
Antecedents to the Entrepreneurial Decision: An Empirical Analysis of Three Predictive Models

This study investigates the entrepreneurial decision to start a new independent business venture. Specifically, this study empirically tests and compares three prominent models of entrepreneurial intention: (1) Ajzen's Theory of Planned Behavior, (2) Shapero's Model of the Entrepreneurial Event, and (3) Davidsson's Determinants of Entrepreneurial Intentions. An extensive search and synthesis of literature germane to the entrepreneurial decision was undertaken to identify factors relevant to the decision to become an entrepreneur, resulting in the selection of three intentions-based models particularly worthy of further investigation and empirical testing. A representative entrepreneurship database (PSED) of 669 nascent US entrepreneurs was used to create individual comprehensive venture profiles, which were then used to code constructs identified in the three models under investigation. Structural equation modeling was used to analyze the predictive capability of the three intentions-based models. The study resulted in seven noteworthy findings. First, although Ajzen's model proved more parsimonious overall and more powerful in explaining entrepreneurial intentions, Shapiro's model proved more powerful in predicting entrepreneurial activity. Second, the specific components from each of the three intentions-based models exhibited explanatory power, and a composite model of these influential constructs increased R2 from an average of 0.34 among the three tested models to 0.43 in the composite model. Third, the 669 individual profiles created from the PSED panel data proved effective in measuring the constructs utilized in this study, and shows promise for providing a source of generalizable data for future entrepreneurship research. Fourth, an extensive two-day rater training workshop increased inter-rated reliability from 0.41 to 0.91, supporting the use of such training. Fifth, the study found that the entrepreneurial decision actually consists of two fundamental types of choices, one to pursue an entrepreneurial career and another to pursue a specific market opportunity. Sixth, wealth aspirations proved to vary tremendously among nascent entrepreneurs and often change dramatically over time. Finally, entrepreneurs in this study tended to underestimate the challenge of employee management, often dramatically adjusting their employee projections downward over time.
Identity Cards and Identity Romanticism

This book chapter for "Lessons from the Identity Trail: Anonymity, Privacy and Identity in a Networked Society" (New York: Oxford University Press, 2009) - a forthcoming comparative examination of approaches to the regulation of anonymity edited by Ian Kerr - discusses the sources of hostility to National ID Cards in common law countries. It traces that hostility in the United States to a romantic vision of free movement and in England to an equally romantic vision of the 'rights of Englishmen'. Governments in the United Kingdom, United States, Australia, and other countries are responding to perceived security threats by introducing various forms of mandatory or nearly mandatory domestic civilian national identity documents. This chapter argues that these ID cards pose threats to privacy and freedom, especially in countries without strong data protection rules. The threats created by weak data protection in these new identification schemes differ significantly from previous threats, making the romantic vision a poor basis from which to critique (highly flawed) contemporary proposals.
Mark F. Meier 1925 to 2012

Mark Meier, wearing a national Georgian cap at the Grossaletschgletscher, Switzerland, in 1978, following a conference in Tbilisi. Photo by Vladimir Kotlyakov.In 1981 I was a new graduate student a...
Phosphorus magnetic resonance spectra and changes in body composition during weight loss.

The use of magnetic resonance spectroscopy (MRS) to monitor cellular bioenergetics during weight loss may provide novel insights regarding metabolic functioning.Changes were noted in 18 sedentary, moderately overweight women following a 7-week program consisting of a low-fat, 422-428 MJ/day (1010-1025 kcal/day) diet, a progressive walking program, a vitamin-mineral-fortified, isolated-protein meal supplement drink and a weekly group meeting. Mitochondrial energy production and utilization were assessed by measuring the concentrations of inorganic phosphate (Pi) and phosphocreatine (PCr) through magnetic resonance spectroscopy. Anthropometric changes were also monitored.Dietary analysis of subjects' pre-intervention food records showed intakes of numerous vitamins and minerals below 100% of the Recommended Dietary Allowances (RDA), most commonly for folic acid, vitamin E, magnesium, iron and zinc. Relative to pre-intervention levels, final measurements showed that all women lost body weight, ranging from 2...
Human DNA polymerase α in binary complex with a DNA:DNA template-primer

The Polα/primase complex assembles the short RNA-DNA fragments for priming of lagging and leading strand DNA replication in eukaryotes. As such, the Polα polymerase subunit encounters two types of substrates during primer synthesis: an RNA:DNA helix and a DNA:DNA helix. The engagement of the polymerase subunit with the DNA:DNA helix has been suggested as the of basis for primer termination in eukaryotes. However, there is no structural information on how the Polα polymerase subunit actually engages with a DNA:DNA helix during primer synthesis. We present here the first crystal structure of human Polα polymerase subunit in complex with a DNA:DNA helix. Unexpectedly, we find that portion of the DNA:DNA helix in contact with the polymerase is not in a B-form but in a hybrid A-B form. Almost all of the contacts observed previously with an RNA primer are preserved with a DNA primer--with the same set of polymerase residues tracking the sugar-phosphate backbone of the DNA or RNA primer. Thus, rather than loss of specific contacts, the free energy cost of distorting DNA from B- to hybrid A-B form may augur the termination of primer synthesis in eukaryotes.
Aspirin Can Be Used as Prophylaxis for Prevention of Venous Thromboembolism After Revision Hip and Knee Arthroplasty

Abstract Background The optimal prophylaxis for prevention of venous thromboembolic events (VTEs) after revision total joint arthroplasty (TJA) remains unknown. The objective of this study was to evaluate whether aspirin, known to be effective for prevention of VTEs after primary arthroplasty, is also effective after revision TJA. Methods We studied 2997 consecutive patients who underwent revision TJA between 2005 and 2013 and were treated with intermittent pneumatic compression devices and either aspirin (534 patients) or warfarin (2463 patients) for VTE prophylaxis. Pertinent data including the incidence of symptomatic VTEs, bleeding events, infection, and mortality were retrieved from our prospectively collected database. Results The incidence of symptomatic VTEs was significantly higher in the warfarin group at 1.75% (43 of 2463) compared with 0.56% (3 of 534) in the aspirin group (odds ratio: 3.2; 95% CI: 1.03-16.3; P = .03). There was a higher rate of bleeding events with administration of warfarin (1.5%) compared with aspirin (0.4%; P = .02; odds ratio: 4.1; 95% CI: 1.2-34.0). The rate of surgical site infection was similar between the aspirin group and the warfarin group (1.61% and 1.70%, respectively). Conclusion Administration of aspirin as prophylaxis against VTEs after revision arthroplasty may be a viable option as it appears to be more effective than warfarin in prevention of symptomatic VTEs and is associated with a lower rate of complications.
The Undiagnosed Diseases Program.

EnglishWe have some concerns and questions related to the Undiagnosed Diseases Program (UDP) described by Dr Gahl and colleagues.1 The stated purpose of this program was to evaluate “patients and families for whom medicine has failed to provide a diagnosis.”1 However, it is not clear that this program is meeting the intended goals. Despite a significant investment of time and money, many patients remain undiagnosed because of long wait times, limited program accessibility, and low diagnostic output. EnglishDrs Drolet and Brower question the value of diagnosis and discovery as promoted by the UDP. Not only has the NIH supported this initiative, but the evaluation of desperate patients seeking a diagnosis has been embraced by members of Congress, hundreds of patients, numerous advocacy groups, and the press. Several centers have begun their own undiagnosed diseases programs without federal funding, and there is strong international interest, with the establishment of the Undiagnosed Diseases Network (UDN) International.1 Demand for the UDP greatly exceeded capacity, which is why the program was extended nationally to improve patient accessibility, with 7 clinical sites across the United States and a streamlined online application process through the UDN Gateway. Long wait times and relatively low diagnostic yield are intrinsic elements of the diseases under investigation; the delays have to do with obtaining records from previous investigations, and the diagnostic output reflects the fact that these exquisitely selected cases have already been evaluated at tertiary medical centers.
Outcome of twin-twin transfusion diagnosed before 28 weeks of gestation.

To develop prognostic indicators for those patients diagnosed with twin-twin transfusion before 28 weeks' gestation, we conducted a retrospective analysis of all cases diagnosed at Baylor College of Medicine from January 1985 through April 1989. Twenty-seven cases of twin-twin transfusion were diagnosed by ultrasound; the criteria for diagnosis were polyhydramnios in one amniotic cavity and oligohydramnios in the other cavity. The mean (+/- SD) age at diagnosis was 21.9 +/- 2.9 weeks and the mean age at delivery was 26.8 +/- 4.9 weeks. Gestational age at diagnosis was similar in survivors and non-survivors (21.7 +/- 3.7 versus 22.2 +/- 2.8 weeks; P = .35); however, surviving infants were delivered later in gestation (31.9 +/- 3.5 versus 25.9 +/- 3.4 weeks; P = .000008). The overall survival rate was 21%. Fetal hydrops correlated with poor survival. Amniocentesis for decompression and tocolysis failed to decrease perinatal mortality.
Laparoscopy for cryptorchidism.

AbstractLaparoscopy is suggested as an accurate way to localize the non-palpable testicle or to diagnose anorchia without an abdominal exploration. From our early experience laparoscopy will aid greatly in the management of the intra-abdominal testicle
Software Defined Radio for direction-finding in UAV wildlife tracking

Two Software Defined Radio (SDR) approaches for assisted wildlife tracking with a multi-rotor Unmanned Aerial Vehicle (UAV) are described. The approaches are Pseudo Doppler (PD) and Yagi Rotation (YR), where each method corresponds to a common Radio Direction-Finding (RDF) technique. Pseudo Doppler utilizes the Doppler Effect by digitally sampling four (or more) monopole antennas in a sequential and circular order, simulating the rotation of a single monopole antenna. This approach can be complex with SDRs and suffers from reduced signal reception from the omnidirectional monopoles. The Yagi Rotation technique utilizes the directional Yagi antenna, rotating 360° about the antenna's center of mass. As the antenna is rotated, the SDR System calculates the Signal to Noise Ratio (SNR) and Angle of Arrival (AoA) of the incoming radio signal. The Yagi Rotation was implemented and field tested; numeric results shown in this paper indicate that system accuracy is limited to the azimuth beamwidth of the Yagi antenna. Due to complexity and reduced signal reception from omnidirectional monopoles, the Pseudo Doppler approach was not implemented; however, a system design is presented. Finally, the SDR methodology and UAV control implications of each approach are discussed in this paper.
Reliability and Maintainability Data for Lead Lithium Cooling Systems

This paper presents component failure rate data for use in assessment of lead lithium cooling systems. Best estimate data applicable to this liquid metal coolant are presented. Repair times for similar components are also referenced in this paper. These data support probabilistic safety assessment and reliability, availability, maintainability, and inspectability analyses.
Global tool-path smoothing for CNC machine tools with uninterrupted acceleration

Abstract Majority of tool-paths for high-speed machining is composed of series of short linear segments, so-called G01 moves. This discrete tool-path format limits the achievable speed and accuracy of CNC machines. To generate continuous feed motion along sharp cornered tool-paths, most NC systems smooth corners locally using a pre-specified curve or a spline and slow down to be able to change the feed direction within machine kinematic limits. Path speed is dramatically reduced for accuracy if sharp corners are within close vicinity. This paper proposes a new real-time interpolation algorithm for NC systems to generate continuous rapid feed motion along short segmented linear tool-paths by smoothing local and adjacent corners that are within close vicinity. Instead of locally modifying the corner geometry with a spline, the proposed algorithm directly blends axis velocities between consecutive linear segments based on the jerk limited acceleration profile (JLAP) and generates cornering trajectories within user-specified contour errors and kinematic limits of the drives. A novel Look-Ahead Windowing (LAW) technique is developed to plan tangential feed profile with uninterrupted acceleration to continuously smooth the path. The feed profile is optimized to generate rapid motion along overlapping adjacent corners. Simulation and experimental results demonstrate effectiveness of the proposed method to interpolate accurate Cartesian high-speed motion along short-segmented tool-paths for machining free-form surfaces found in dies, molds and aerospace parts.
Chemically controlled surface compositions of Ag-Pt octahedral catalysts

A hydrothermal method was developed to synthesize Ag–Pt nanoparticles with controlled surface composition where formaldehyde (HCHO) was utilized as a directing agent. Transmission electron microscopy and powder x-ray diffraction characterizations showed no change in bulk composition and phases as well as the size and morphology of as-made bimetallic nanocrystals. X-ray photoelectron spectroscopy study revealed, however, the enrichment of Pt on the surface as the amount of HCHO used increased. This chemically driven change in surface composition represents a nontraditional approach in the control of synthesis of bimetallic nanoparticle catalysts. A close relationship between catalytic performance and surface composition of these Ag–Pt nanocrystals was observed for electrochemical oxidation of formic acid.
Assessment of inventory class performance utilising inventory turn and days on hand

Inventory performance is typically based on individual SKU rather than on class of SKUs. This research evaluates ABC inventory classes for performance based on class inventory turn. Multiple multi-criteria inventory control (MCIC) models are used to classify 47 stock-keeping units into A, B, and C categories and their ABC classes' annual performance evaluated for each model. The results show that A-class consistently has highest turns than B and C classes. For the eight models evaluated all but the R-model show higher turns for A class than both B or C class. B and C classes turn inventory relatively the same number of times with the exception of the R-model. The R-model turns C-class inventory higher than A-class or B-class inventory contrary to ABC principles. The results show that inventory classification can be limited to A and B classes instead of the numerous classes sometimes recommended and practiced in many firms.
A method of diagnosing personality in the psychological clinic

Since the strictly psychological field of personality disorders usually requires rational psychotherapeutic measures diagnosis in this field assumes a unique role. The formulation of his problem which a patient is able to make at the end of his diagnostic interview is more important than a tabulation of his reactions during the course of his interview. In order to facilitate the rapid progress of the interview toward the revelation of important material and to lead more rapidly to a satisfactory formulation of the patient’s problems a diagnostic interview form is presented. Its items consist principally of points which have been the recognized turning points in the successful rational psychotherapy of actual cases. Arrangement of the items has been determined by simple experimentation. Illustrative phrasing of initial questions is suggested.
Self-Assembled Plasmonic Metamolecules Exhibiting Tunable Magnetic Response at Optical Frequencies

A bottom-up self-assembly approach is used to synthesize pseudospherical clusters of Au nanoparticles with low size and shape polydispersity. Such plasmonic metamolecules (PMMs) with various diameters are prepared from two different AuNP building block sizes, enabling the investigation of the size-dependent optical properties of these structures. Trends in the UV–vis spectra are reproduced theoretically using generalized multiparticle Mie theory as either the AuNP or PMM diameter are changed. The calculated results indicate that features in the spectra of large PMMs can be associated with magnetic dipole resonances, which strengthen and red-shift with increasing PMM size. Finally, effective medium theory is used to demonstrate that materials composed of these PMMs could exhibit a bulk isotropic magnetic response at optical frequencies.
CORRELATION OF DATA AND PREDICTION OF EFFECTIVENESS FROM FILM COOLING INJECTION GEOMETRIES OF A PRACTICAL NATURE

Summary The simple boundary layer theory of Stollery and El-Ehwany, which has been applied with some success to idealized injection slots, is extended to account for the velocity defect introduced into the injected film by the finitely thick slot lip and the boundary layers which exist on it. The resulting equations are used to provide a correlation group which is tested against the collected experimental data from nine practical injection geometries of greatly differing construction, over wide ranges of velocity and temperature ratios, and slot Reynolds number. For individual geometries effectiveness correlation to ±5% of unity is achieved; for geometries of the same general class a “universal” correlation of ±10% is obtained. Equations are obtained which describe the data within these limits. These equations are shown to be valid for differing mainstream approach boundary layers and differing turbulence levels in both main and injected streams. In view of the present general uncertainties associated with adequately specifying the mainstream conditions for application to the gas-turbine combustion chamber, the present simple equations are both suitable and convenient for predicting film effectiveness for preliminary design work and thermal analysis.
XLIII. On the detection and estimation of colophony (common rosin) when dissolved in the fixed oils

(1840). XLIII. On the detection and estimation of colophony (common rosin) when dissolved in the fixed oils. The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science: Vol. 17, No. 110, pp. 289-292.
Misinformation and Identity-Protective Cognition

This paper synthesizes existing work on misinformation relating to policy-relevant facts. It argues that misinformation has the greatest power to mislead when it interacts with identity-protective cognition.
Consumption of fast food, sugar-sweetened beverages, artificially-sweetened beverages and allostatic load among young adults.

Abstract This study investigates the associations between recent consumption of fast foods, sugar-sweetened beverages, and artificially-sweetened beverages on level of allostatic load, a measure of cumulative biological risk, in young adults in the US. Data from Wave IV of the National Longitudinal Study of Adolescent to Adult Health were analyzed. Negative binomial regression models were used to estimate the associations between consumption of fast foods, sugar-sweetened, and artificially-sweetened beverages and allostatic load. Poisson and logistic regression models were used to estimate the associations between these diet parameters and combined biomarkers of physiological subsystems that comprise our measure of allostatic load. All analyses were weighted and findings are representative of young adults in the US, ages 24–34 in 2008 (n = 11,562). Consumption of fast foods, sugar-sweetened, and artificially-sweetened beverages were associated with higher allostatic load at a bivariate level. Accounting for demographics and medication use, only artificially-sweetened beverages remained significantly associated with allostatic load. When all three dietary components were simultaneously included in a model, both sugar- and artificially-sweetened beverage consumption were associated with higher allostatic load. Differences in allostatic load emerge early in the life course and young adults consuming sugar- or artificially-sweetened beverages have higher allostatic load, net of demographics and medication use. Public health messages to young adults may need to include cautions about both sugar- and artificially-sweetened beverages.
The Importance of Parents' Community Connections for Adolescent Well-being: An Examination of Military Families.

Drawing from the Social Organization Theory of Action and Change (SOAC), this analysis of 223 military families, including active duty (AD) military and civilian partners, examines how parents' sense of community and community engagement (two elements of community connections) are associated with their own resilient coping, and ultimately with important outcomes capturing their adolescent offspring's individual well-being (depression, anxiety, and self-efficacy) and family well-being (family functioning and parenting quality). The roles of child gender and military context were also examined. Parents with stronger community connections, including greater sense of community and community engagement, reported more resilient coping when faced with adversity. The resilient coping of mothers, in turn, was particularly significant for more positive youth outcomes, when compared to that of fathers. While gender and military context were associated with individual and family well-being, analyses of model invariance indicated that the model fit similarly for male and female adolescents and those experiencing high and low levels of military transitions. Indirect effects were also examined. These findings illuminate malleable dimensions of both community life and family life, primarily showing that community contexts matter for multiple family members.
PSMD5 inactivation promotes 26S proteasome assembly during colorectal tumor progression

Protein degradation by the ubiquitin-proteasome system (UPS) is central to protein homeostasis and cell survival. The active 26S proteasome is a large protease complex consisting of a catalytic 20S subunit and 19S regulatory particles. Cancer cells are exposed to considerable protein overload due to high metabolic rates, reprogrammed energy metabolism, and aneuploidy. Here we report a mechanism that facilitates the assembly of active 26S proteasomes in malignant cells. Upon tumorigenic transformation of the gut epithelium, 26S proteasome assembly was significantly enhanced, but levels of individual subunits were not changed. This enhanced assembly of 26S proteasomes increased further with tumor progression and was observed specifically in transformed cells, but not in other rapidly dividing cells. Moreover, expression of PSMD5, an inhibitor of proteasome assembly, was reduced in intestinal tumors and silenced with tumor progression. Reexpression of PSMD5 in tumor cells caused decreased 26S assembly and accumulation of polyubiquitinated proteins. These results suggest that inhibition of cancer-associated proteasome assembly may provide a novel therapeutic strategy to selectively kill cancer cells.Significance: Enhanced cancer-associated proteasome assembly is a major stress response that allows tumors to adapt to and to withstand protein overload.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/78/13/3458/F1.large.jpg Cancer Res; 78(13); 3458-68. ©2018 AACR.
Novel Anatomical Observations of the Prostate, Prostatic Vasculature and Penile Vasculature in Classic Bladder Exstrophy Using Magnetic Resonance Imaging.

Purpose: We used magnetic resonance imaging to define the innate pelvic neurovascular course and prostatic anatomy in infants with classic bladder exstrophy before the pelvis was altered by surgery.Materials and Methods: Pelvic magnetic resonance imaging was performed in male infants with classic bladder exstrophy and compared to a group of age matched controls. Data collected included prostatic dimensions as well as course of the prostatic artery, periprostatic vessels and pudendal neurovasculature.Results: The prostate was larger in the transverse (p <0.001) and anteroposterior (p <0.001) dimensions in patients with classic bladder exstrophy compared to those with normal prostates but was smaller in the craniocaudal dimension (p <0.001). This finding resulted in a larger calculated prostate volume in patients with classic bladder exstrophy compared to controls (p = 0.015). The pelvic vasculature and prostatic artery followed a similar course in patients with classic bladder exstrophy and controls. Relat...