cssi/SciSciGPT-SciSciNet huggingface dataset:
Evaluation of Media and Derivatization Chemistry for Six Aldehydes in a Passive Sampler

We evaluated the GMD passive sampler for its suitability to measure six aldehydes over a 7-d period in population exposure studies. The six target aldehydes were formaldehyde, acetaldehyde, acrolein, crotonaldehyde, glyoxal, and methylglyoxal. The GMD sampler contains a silica gel-impregnated cellulose pad coated with 2,4-dinitrophenylhydrazine (DNPH) hydrochloride. This agent reacts with formaldehyde to form a hydrazone that is quantified with a high-performance liquid chromatograph. The GMD sampler was tested for background contamination and aldehyde recoveries after 0, 1, and 7 d of storage. Results indicated that the GMD monitor, as currently manufactured, is suitable for shorter-term sampling (up to 24 h) of formaldehyde and acetaldehyde. It is however not acceptable for sampling of acetaldehyde, acrolein, crotonaldehyde, glyoxal, and methylglyoxal over a 7-d exposure period due to the chemical reactions on the silica gel-impregnated cellulose pad. Glyoxal- and methylglyoxal-DNPH derivatives formed on the cellulose and Teflon-coated glass fiber pads that had been prepared with glycerol under acidic and oxidative conditions. Acrolein- and crotonaldehyde-DNPH derivatives diminish through the reverse reaction of the DNPH derivatives to form free aldehydes under acidic conditions. We showed that the unknown reaction products of acrolein and crotonaldehyde derivatives were not pyrazolines but probably resulted from E/Zisomerization. These conversion reactions are favored in acidic conditions present in either the derivatization solution or the collection medium. The most consistent recovery was obtained on glass fiber pads. In particular, recoveries of crotonaldehyde- and acrolein-DNPH derivatives were increased through the use of a pH 4 buffered derivatization solution. These chemical instability problems were overcome by using a pH 4 buffer (citric acid/sodium citrate) and an alternative hygroscopic agent (1,3-butanediol) in the DNPH derivatization solution. Results with DNPH derivatives from these spiking experiments were further confirmed with gas-phase spiking experiments. We determined the optimal acidity, buffer solution, and concentrations of the buffer solution and 1,3-butanediol for the DNPH derivatization solution. This new formulation of the DNPH derivatization solution can be used for collection of the six target aldehydes over a 7-d sampling period.
Radiation Effects in Glass Waste Forms for High-Level Waste and Plutonium Disposal

A key challenge in the permanent disposal of high-level waste (HLW), plutonium residues/scraps, and excess weapons plutonium in glass waste forms is the development of predictive models of long-term performance that are based on a sound scientific understanding of relevant phenomena. Radiation effects from β-decay and α-decay can impact the performance of glasses for HLW and Pu disposition through the interactions of the α-particles, β-particles, recoil nuclei, and γ-rays with the atoms in the glass. Recently, a scientific panel convened under the auspices of the DOE Council on Materials Science to assess the current state of understanding, identify important scientific issues, and recommend directions for research in the area of radiation effects in glasses for HLW and Pu disposition. The overall finding of the panel was that there is a critical lack of systematic understanding on radiation effects in glasses at the atomic, microscopic, and macroscopic levels. The current state of understanding on radiation effects in glass waste forms and critical scientific issues are presented.
Bringing order to the arbitrary : One- to two-year-olds' recall of event sequences

Abstract Recall by children ages 16–32 months was tested on event sequences that were either arbitrarily ordered or were constrained by enabling relations. Even the youngest children reliably recalled the enabling sequences. It was not until 20 months and older that the children performed at above-chance levels on the arbitrarily ordered events.
Relation of types of dietary fat to cardiovascular damage in mice

Nine edible oils or fats (hydrogenated coconut, cod liver, Wesson, linseed, olive, butter, lard, corn and cocoa-butter) were fed for 50–90 days to study the relation of saturation, chain length and essential fatty acid content to production of cardiovascular lesions. The specific oil or fat (selected for ranges in the above variables) was used as the dietary lipid in a high-fat (28%), low-protein (8%), hypolipotropic diet. Half of the animals received identical diets containing choline chloride (2 gm/100 gm of diet) as a lipotropic supplement. Atrial mural thrombosis and ventricular myocardial necrosis and calcification developed in all dietary groups. Atrial thrombosis was the most frequent lesion. The greatest incidence of atrial thrombosis occurred in mice fed the choline-deficient, butter-containing diet (92%) and the lowest incidence with the supplemented cod liver oil diet (20%). The diet containing unsupplemented hydrogenated coconut oil produced the greatest incidence of ventricular necrosis (79%) and that with choline-supplemented cocoa-butter the lowest (8%). Ventricular calcification was most extensive within the unsupplemented cod liver oil group (83%), most limited in the supplemented lard group (5%). In general, choline-supplemented diets produced a lower incidence of cardiac damage. Little correlation existed between the composition and characteristics of specific fats and their activity in producing the specific cardiac lesions observed here.
The Effect of the Study Session on Test Performance

(1982). The Effect of the Study Session on Test Performance. Teaching of Psychology: Vol. 9, No. 2, pp. 118-120.
The relationship of size and biomass to fission rate in a clone of the sea anemone, Haliplanella luciae (Verrill)

Abstract Genetically identical clones of Haliplanella luciae (Verrill) were reared in vitro, and the rate of asexual reproduction (fission), individual dry weight and clonal biomass was determined. When temperature increases, the size of individual anemones decreases due to an increased fission rate ( k ) and increased catabolism. At 26°C increased food availability caused decreased individual size, due to increased k ; at 21 and 16°C, no feeding effect was evident. Mean individual size is a linear function of k ; the resulting regression equation is given, and its use for prediction of k in natural populations is discussed. At low values of k (i.e., low temperature), clonal biomass increases in proportion to feeding frequency. At high values of k , biomass decreases, indicating that k is maximized at considerable cost in terms of tissue growth. This suggests that for H. luciae , maximizing k provides a benefit other than that of maximizing net energetic input and growth efficiency.
Benchmarking a computerized test of immediate verbal memory

We modified the traditional (verbal) digit span task for administration via computer and the Internet. This online version collects data on the floor and ceiling of a subject’s span capacity, rather than generating a rough estimate of capacity based on a 50% success rate, as the traditional version does. We compared the two versions within adult subjects in two cohorts: college-age normal readers and college-age reading-disabled readers. To explore the reliability of the online version as a research tool, we employed the Bland-Altman approach to examine agreement between instruments. The online version yielded spans similar to those yielded by the traditional version, tending toward smaller values at the high end and larger values at the low end of span sizes, in the typical readers. It differentiated between the better and poorer readers reliably, and to the same extent as does the verbal version. The online version of the digit span task is comparable to the traditional version in assessing verbal span capacity; the code with which to implement the task is available at www.psychonomic.org/archive.
Growth mechanism of hexagonal-shape graphene flakes with zigzag edges.

The properties of a graphene nanostructure are strongly influenced by the arrangement of the atoms on its edge. Growing graphene nanostructures with specified edge types in practical, scalable ways has proven challenging, with limited success to date. Here we report a method for producing graphene flakes with hexagonal shape over large areas, by a brief chemical vapor deposition growth at atmospheric pressure on polished Cu catalyst foil, with limited carbon feedstock. Raman spectra show evidence that the edges of the hexagonal crystallites are predominantly oriented along the zigzag direction. Density functional theory calculations demonstrate that the edge selectivity derives from favorable kinetics of sequential incorporation of carbon atoms to the vacancies in nonzigzag portions of the edges, driving the edges to pure zigzag geometry. This work represents an important step toward realization of graphene electronics with controlled edge geometries, which might find use in digital logic applications or ...
Wu and Sridhar reply.

A reply to the comment on relation between Bc and pinning-force constant in YBaCuO is given. The authors claim they did not say Bc is anisotropic, and though Bc is isotropic, pinning-force constant need not be. The relation between these two arises under assumptions of core pinning. (AIP)
Zombie Alleluias: Learning to Live in the Space Between Worlds

This essay was delivered as the Baer Seminar on Pastoral Care at an alumni/ae reunion of Princeton Theological Seminary on October 22, 2013, and at a Princeton Seminary alumni/ae gathering at Preston Hollow Presbyterian Church in Dallas, Texas, on February 10, 2014. It considers an increasing fascination with zombies in recent American cultural life as a means by which individuals attempt to cope with anxieties related to the rise of political and religious extremism in the post-9/11 landscape. Building on Freud’s recognition of fundamentalist tendencies within the human psyche and his sense that modern persons are living psychologically “beyond their means,” it calls for an empathic embrace of the complexities of what Donald Capps deems the “ecumenical self” as a path toward engaging personal threats within and without.
Intrapulmonary pharmacokinetics and pharmacodynamics of high-dose levofloxacin in healthy volunteer subjects

The objective of this study was to determine the plasma and intrapulmonary pharmacokinetic parameters of intravenously administered levofloxacin in healthy volunteers. Three doses of either 750 mg or 1000 mg levofloxacin were administered intravenously to 4 healthy adult subjects (750 mg) to 20 healthy adult subjects divided into five groups of 4 subjects (1000 mg). Standardised bronchoscopy and timed bronchoalveolar lavage (BAL) were performed following administration of the last dose. Blood was obtained for drug assay prior to drug administration and at the time of BAL. Levofloxacin was measured in plasma, BAL fluid and alveolar cells (ACs) using a sensitive and specific combined high-performance liquid chromatographic tandem mass spectrometric technique (HPLC/MS/MS). Plasma, epithelial lining fluid (ELF) and AC pharmacokinetics were derived using non-compartmental methods. The maximum plasma drug concentration to minimum inhibitory concentration ratio (C(max)/MIC(90)) and the area under the drug concentration curve to minimum inhibitory concentration ratio (AUC/MIC(90)) during the dosing interval were calculated for potential respiratory pathogens with MIC(90) values from 0.03 microg/mL to 2 microg/mL. In the 1000 mg dose group, the C(max) (mean+/-standard deviation (S.D.)), AUC(0-8h) and half-life were: for plasma, 9.2+/-1.9 microg/mL, 103.6 microg h/mL and 7.45 h; for ELF, 25.8+/-7.9 microg/mL, 279.1 microg h/mL and 8.10h; and for ACs, 51.8+/-26.2 microg/mL, 507.5 microg h/mL and 14.32 h. In the 750 mg dose group, the C(max) values in plasma, ELF and ACs were 5.7+/-0.4, 28.0+/-23.6 and 34.2+/-18.7 microg/mL, respectively. Levofloxacin concentrations were significantly higher in ELF and ACs than in plasma at all time points. For pathogens commonly associated with community-acquired pneumonia, C(max)/MIC(90) ratios in ELF ranged from 12.9 for Mycoplasma pneumoniae to 859 for Haemophilus influenzae, and AUC/MIC(90) ratios ranged from 139 to 9303, respectively. The C(max)/MIC(90) ratios in ACs ranged from 25.9 for M. pneumoniae to 1727 for H. influenzae, and AUC/MIC(90) ratios ranged from 254 to 16917, respectively. The C(max)/MIC(90) and AUC/MIC(90) ratios provide a pharmacokinetic rationale for once-daily administration of a 1000 mg dose of levofloxacin and are favourable for the treatment of community-acquired respiratory pathogens.
A new approach to tracking connections between the Indus Valley and Mesopotamia: initial results of strontium isotope analyses from Harappa and Ur

Exchange and interaction between early state-level societies in Mesopotamia and the Indus Valley during the 3rd millennium BC has been documented for some time. The study of this interaction has been dominated by the analysis of artifacts such as carnelian beads and marine shell, along with limited textual evidence. With the aid of strontium, carbon, and oxygen isotopes, it is now possible to develop more direct means for determining the presence of non-local people in both regions. This preliminary study of tooth enamel from individuals buried at Harappa and at the Royal Cemetery of Ur, indicates that it should be feasible to identify Harappans in Mesopotamia. It is also possible to examine the mobility of individuals from communities within the greater Indus Valley region.
Impression formation as a function of the sex role appropriateness of linguistic behavior

Differences between perceptions of men's and women's language were investigated. Undergraduates (64 male, 64 female) read 14 short stories with male or female speakers using seven categories of “male” and “female” language. Subjects then rated stimulus persons on 23 sex role related adjectives. Male language was rated as more masculine, less feminine, more “instrumental,” and less “socially positive” than female language. Effects were strongest for the categories of expletives and adjectives, followed by weaker effects for hedges and polite forms. Subjects rated males who spoke women's language as homosexual; they tended to rate females who spoke men's language as uppity. The results are discussed in terms of Robin Lakoff's hypotheses concerning linguistic sex differences and in terms of inrole vs out-of-role behavior.
Phospholamban: A Prominent Regulator of Myocardial Contractility

Our understanding of the role of phospholamban in cardiac physiology has evolved over the past two decades to the point where this protein is now understood to be a critical repressor of myocardial contractility. Phospholamban, through its inhibitory effects on the affinity of the cardiac sarcoplasmic reticulum Ca2+ pump for Ca2+, represses both the rates of relaxation and contraction in the mammalian heart. These inhibitory effects can be relieved through (1) phospholamban phosphorylation, (2) down-regulation of phospholamban gene expression, and (3) disruption of the phospholamban-Ca(2+)-ATPase interaction. Thus, genetic approaches and pharmacological interventions, designed to relieve the phospholamban inhibitory action on the cardiac sarcoplasmic reticulum Ca2+ pump and myocardial relaxation, may prove valuable in reversing the effects of several diseases in the mammalian heart. Such interventions could be designed to inhibit the phospholamban phosphatase, stabilize the phosphorylated state of phospholamban, interrupt the phospholamban-Ca(2+)-ATPase interaction, decrease phospholamban transcription, or disrupt phospholamban mRNA stability. Development of such therapeutic strategies to target phospholamban will be an important future goal for the clinical improvement of contractility in the failing heart.
Simultaneous quantification of cannabinoids and metabolites in oral fluid by two-dimensional gas chromatography mass spectrometry

Abstract Development and validation of a method for simultaneous identification and quantification of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabinol (CBN), and metabolites 11-hydroxy-THC (11-OH-THC) and 11-nor-9-carboxy-THC (THCCOOH) in oral fluid. Simultaneous analysis was problematic due to different physicochemical characteristics and concentration ranges. Neutral analytes, such as THC and CBD, are present in ng/mL, rather than pg/mL concentrations, as observed for the acidic THCCOOH biomarker in oral fluid. THCCOOH is not present in cannabis smoke, definitively differentiating cannabis use from passive smoke exposure. THC, 11-OH-THC, THCCOOH, CBD, and CBN quantification was achieved in a single oral fluid specimen collected with the Quantisal™ device. One mL oral fluid/buffer solution (0.25 mL oral fluid and 0.75 mL buffer) was applied to conditioned CEREX ® Polycrom™ THC solid-phase extraction (SPE) columns. After washing, THC, 11-OH-THC, CBD, and CBN were eluted with hexane/acetone/ethyl acetate (60:30:20, v/v/v), derivatized with N , O -bis-(trimethylsilyl)trifluoroacetamide and quantified by two-dimensional gas chromatography electron ionization mass spectrometry (2D-GCMS) with cold trapping. Acidic THCCOOH was separately eluted with hexane/ethyl acetate/acetic acid (75:25:2.5, v/v/v), derivatized with trifluoroacetic anhydride and hexafluoroisopropanol, and quantified by the more sensitive 2D-GCMS–electron capture negative chemical ionization (NCI-MS). Linearity was 0.5–50 ng/mL for THC, 11-OH-THC, CBD and 1–50 ng/mL for CBN. The linear dynamic range for THCCOOH was 7.5–500 pg/mL. Intra- and inter-assay imprecision as percent RSD at three concentrations across the linear dynamic range were 0.3–6.6%. Analytical recovery was within 13.8% of target. This new SPE 2D-GCMS assay achieved efficient quantification of five cannabinoids in oral fluid, including pg/mL concentrations of THCCOOH by combining differential elution, 2D-GCMS with electron ionization and negative chemical ionization. This method will be applied to quantification of cannabinoids in oral fluid specimens from individuals participating in controlled cannabis and Sativex ® (50% THC and 50% CBD) administration studies, and during cannabis withdrawal.
Software Review: The Planners Lab? modelling and visualisation system

The Planners Lab (PL) is a modelling and visualisation application written and distributed by GRW Studios, Inc., Omaha, Nebraska. It is designed primarily for financial planning applications, but may be used for other simulation modelling as well. It operates as both a desktop application under Microsoft Windows and as a web product. It was released in 2006. It is available for no cost for academic use. A review of the product is given.
Continuous PTH and PTHrP Infusion Causes Suppression of Bone Formation and Discordant Effects on 1,25(OH)2Vitamin D

Osteoblast activity and plasma 1,25(OH)2vitamin D are increased in HPT but suppressed in HHM. To model HPT and HHM, we directly compared multiday continuous infusions of PTH versus PTHrP in humans. Continuous infusion of both PTH and PTHrP results in marked and prolonged suppression of bone formation; renal 1,25(OH)2D synthesis was stimulated effectively by PTH but poorly by PTHrP. Introduction: PTH and PTH-related protein (PTHrP) cause primary hyperparathyroidism (HPT) and humoral hypercalcemia of malignancy (HHM), respectively. Whereas HHM and HPT resemble one another in many respects, osteoblastic bone formation and plasma 1,25(OH)2vitamin D are increased in HPT but reduced in HHM. Materials and Methods: We performed 2- to 4-day continuous infusions of escalating doses of PTH and PTHrP in 61 healthy young adults, comparing the effects on serum calcium and phosphorus, renal calcium and phosphorus handling, 1,25(OH)2vitamin D, endogenous PTH(1-84) concentrations, and plasma IGF-1 and markers of bone turnover. Results: PTH and PTHrP induced comparable effects on renal calcium and phosphorus handling, and both stimulated IGF-1 and bone resorption similarly. Surprisingly, PTH was consistently more calcemic, reflecting a selectively greater increase in renal 1,25(OH)2 vitamin D production by PTH. Equally surprisingly, continuous infusion of both peptides markedly, continuously, and equivalently suppressed bone formation. Conclusions: PTHrP and PTH produce markedly different effects on 1,25(OH)2vitamin D homeostasis in humans, leading to different calcemic responses. Moreover, both peptides produce profound suppression of bone formation over multiple days, contrasting with events in HPT, but mimicking HHM. These findings underscore the facts that the mechanisms underlying the anabolic skeletal response to PTH and PTHrP in humans is poorly understood, as are the signal transduction mechanisms that link the renal PTH receptor to 1,25(OH)2vitamin D synthesis. These studies emphasize that much remains to be learned regarding the normal regulation of vitamin D metabolism and bone formation in response to PTH and PTHrP in humans.
Parental Care and Diet of Mississippi Kites (Ictinia mississippiensis) in Eastern Arkansas

Abstract Few studies have quantified parental care patterns and diets of Mississippi Kites (Ictinia mississippiensis). Using video-recording systems, we quantified and analyzed nesting Mississippi Kite parental care and food delivery in eastern Arkansas. During the incubation period, male kites appeared to spend more time ( = 311.8 min/day, SE = 30.27) on the nest than females ( = 249.6 min/day, SE = 30.62), though the difference was not statistically significant. Females spent significantly more time on the nest during the brooding period than did males. Female kites also spent significantly more time shading nestlings than males. The amount of time that females stayed on the nest overnight during the incubation ( = 886 min/night) and brooding periods ( = 815 min/night) was longer than that of males ( = 806 and 739 min/night, respectively). Male kites delivered more food items (58%) than females (42%) and also delivered significantly more vertebrate food items than did females. Insects were...
Evaluation of the reinforcing and discriminative stimulus effects of 1,4-butanediol and γ-butyrolactone in rhesus monkeys

Abstract Metabolic precursors and prodrugs of γ-hydroxybutyrate (GHB), including 1,4-butanediol (BDL) and γ-butyrolactone (GBL), have sedative and anesthetic effects and might have positive reinforcing effects. BDL and GBL were evaluated using behavioral procedures that measure positive reinforcing effects and discriminative stimulus effects of drugs that modulate γ-aminobutyric acid (GABA) at the GABAA receptor complex. One group of rhesus monkeys could respond for saline or the barbiturate methohexital (i.v.) in a self-administration paradigm. Two other groups of monkeys discriminated the barbiturate pentobarbital (i.g.) or the benzodiazepine midazolam (s.c.) from saline in a drug discrimination paradigm; another group of monkeys was treated with the benzodiazepine diazepam (5.6 mg/kg/day, p.o.) and discriminated the benzodiazepine antagonist flumazenil (s.c.) from vehicle. In self-administration experiments, methohexital and not BDL (0.1–3.2 mg/kg/injection) or GBL (0.1–3.2 mg/kg/injection) reliably maintained responding above saline levels. BDL and GBL, up to doses that suppressed responding, did not substitute for pentobarbital, midazolam or flumazenil. The onset of action for both drugs to decrease response rate was delayed (90 min for GBL and 150 min for BDL). These results suggest that any abuse-related effects of BDL and GBL are qualitatively different from the abuse-related effects of GABAA receptor modulators and further indicate that BDL and GBL do not have positive reinforcing effects in rhesus monkeys experienced with self-administration of a short-acting sedative-hypnotic.
Political interference in climate science

“All of us have a right to our own views about the seriousness of global warming,” U.S. Rep. Henry Waxman (D-Calif.), chair of the House Oversight and Government Reform Committee, said at a 30 January committee hearing held to examine political interference in climate science. “But we don't have a right to our own science.” Waxman added, “This hearing, and the committee's ongoing investigation into political interference, is aimed at ensuring the American people receive the best possible science.”
Small‐scale fluid motion mediates growth and nutrient uptake of Selenastrum capricornutum

Summary 1. A fluid-flow reactor using submersible speakers was constructed to generate small-scale fluid motion similar to conditions measured in open water environments; flow was quantified by particle image velocimetry. Additionally a Couette-type rotating cylinder was used to generate shear flows; flow was quantified using an optical hotwire probe and torque measurements. Growth rates of the green alga Selenastrum capricornutum were determined from changes in cell counts and viability was tested using the fluorogenic probe fluoresceine diacetate. 2. Evidence that fluid motion directly affects growth rates was obtained as a significant difference between growth in a moving versus non-moving fluid. A near 2-fold increase in growth rate was achieved for an energy dissipation rate of ɛ = 10−7 m2 s−3; a rate common in lakes and oceans. The onset of the viability equilibrium, identified as the day of the test period when the number of active cells equalled non-active cells, was delayed by 2 days for moving fluid conditions as compared with a non-moving fluid. 3. Nutrient uptake was determined by a decrease in the bulk fluid concentration and cellular phosphorus concentration was also estimated. The thickness of the diffusive sublayer surrounding a cell, a zone dominated by molecular diffusion, was estimated. Increasing fluid motion was found to decrease the thickness of this layer. The Sherwood number (ratio of total mass flux to molecular mass flux) showed that advective flux surrounding cells dominated molecular diffusion flux with regard to Peclet numbers (ratio of advective transport to molecular diffusion transport). Fluid motion facilitated uptake rates and resulted in increased growth rates, compared with no-flow conditions. The rate-of-rotation and the rate-of-strain in a moving fluid equally mediated the diffusive sublayer thickness surrounding the cells. Our study demonstrates that small-scale fluid motion mediates algal growth kinetics and therefore should be included in predictive models for algal blooms.
Measuring cell identity in noisy biological systems

Global gene expression measurements are increasingly obtained as a function of cell type, spatial position within a tissue and other biologically meaningful coordinates. Such data should enable quantitative analysis of the cell-type specificity of gene expression, but such analyses can often be confounded by the presence of noise. We introduce a specificity measure Spec that quantifies the information in a gene's complete expression profile regarding any given cell type, and an uncertainty measure dSpec, which measures the effect of noise on specificity. Using global gene expression data from the mouse brain, plant root and human white blood cells, we show that Spec identifies genes with variable expression levels that are nonetheless highly specific of particular cell types. When samples from different individuals are used, dSpec measures genes' transcriptional plasticity in each cell type. Our approach is broadly applicable to mapped gene expression measurements in stem cell biology, developmental biology, cancer biology and biomarker identification. As an example of such applications, we show that Spec identifies a new class of biomarkers, which exhibit variable expression without compromising specificity. The approach provides a unifying theoretical framework for quantifying specificity in the presence of noise, which is widely applicable across diverse biological systems.
Characterization of void spaces in mordenites by means of 129Xe NMR

Abstract By observing the 129 Xe spectrum of xenon sorbed on ion exchanged and chemically modified mordenites it is possible to determine the xenon distribution over main-channel and side-pocket sites. In the case of Na + K + and NH 4 + mordenites, side-pocket space is available for xenon sorption; however, in the case of Cs + mordenite it is not. Mildly leached Na + mordenite and also calcined NH 4 + mordenite show enchanced small pore space available for xenon sorption. When a fully loaded mordenite sample is cooled to 160 K, the observation of separate 129 Xe signals from solid, liquid, and sorbed xenon allows a direct determination of the interior surface area of the sample.
P-wave travel time and amplitude in western North America

A study of teleseismic, short-period (1 s) P-wave travel-time and amplitude variations in western North America reported here reveals a high level of correlation: early arrivals relate to low amplitudes and late arrivals to higher amplitudes. This trend is opposite to observations noted for the USA and southern Canada as a whole1. With some exceptions, seismic stations east of the Rocky Mountain front generally record faster travel times2–8 and higher amplitudes9–15 than those to the west. These differences have been attributed to higher attenuation and lower velocities in the upper mantle beneath the tectonically active western region11,16. The correlation in the west between P-wave travel-time residuals and relative amplitudes is consistent with elastic focusing and defocusing effects and is found for both World Wide Standardized Seismograph Network (WWSSN) and Long Range Seismic Measurement (LRSM) stations. These results are relevant to the estimation of yields of nuclear explosions because by reciprocity similar elastic focusing and defocusing effects can alter the amplitudes and travel times of P-waves from explosions.
Development of a simplified phosphorus management model for a shallow, subtropical, urban hypereutrophic lake

Abstract City Park Lake is a shallow, subtropical, urban hypereutrophic lake located in Baton Rouge, Louisiana. By the late 1970s, this artificial lake had experienced extreme eutrophication and suffered from frequent algal blooms and fish kills. Restoration of City Park Lake in 1983 consisted of dredging nutrient-laden sediments and rehabilitating sewage pipelines. Nearly one decade following restoration, filamentous algae became a recurring nuisance. A simplified phosphorus management model was developed to aid local officials in decision-making processes pertaining to the management of the lake and its watershed. The calibrated model was used to evaluate several management strategies for the reduction of in-lake phosphorus levels. The management of sediment phosphorus levels combined with reduced watershed phosphorus concentrations is viewed as the most viable option for the long-term health of the lake.
Oscillations in photodetachment cross sections for negative ions in magnetic fields.

Theory is developed for photodetachment of an electron from a potential well in a magnetic field. The cross section has a maximum as a function of photon energy just above each Landau-level threshold. If the final-state interaction is effectively negative, there is in addition a Feshbach resonance below each of these thresholds, except the first. However, none of these maxima occurs if the final-state wave function is antisymmetric with respect to reflection in a plane perpendicular to the magnetic field direction. The oscillations observed experimentally are attributed to the maxima located above the thresholds, not the Feshbach resonances.
How the alliance pie is split: Value appropriation by each partner in cross-border technology transfer alliances

Almost no academic papers treat a crucial aspect of alliances – the determinants of the division of alliance value over the partners. Analyzing a sample of cross-border alliances, technology providing partners increase their share of total alliance returns when accepting riskier forms of compensation. Returns to a partner, and the risk they assume, are shown to be correlated through minimum sales or minimum royalty agreement clauses. Firms with stronger technical capabilities gain more from technology alliances. The bargaining power wielded by each party, while negotiating the structure of an alliance, influences each partner's share of overall alliance benefits.
Narrative interaction and the development of client autonomy in clinical practice

Data from a psychoanalytic case are used to explore the development of client autonomy in clinical treatment. The client's narratives and the talk about them in which narrative meaning is formulated and reformulated are selected as one series of interactions in which the development of client autonomy can be studied. Discourse analysis methods are adapted to document and describe specific shifts in the structure of client narratives and talk about them which reflect the development of client autonomy over the course of treatment. Implications for casework treatment are discussed.
Ethics Education and Value Prioritization among Members of U.S. Hospital Ethics Committees

Calls for ethics education for members of hospital ethics committees presume that the effects and benefits of such education are well-established. This is not the case. A review of the literature reveals that studies consistently have failed to uncover any significant effect of ethics education on the moral reasoning, moral competency, and/or moral development of medical professionals. The present paper discuss this negative result and describes the author's national study of the value priorities of members of hospital ethics committees. This study discovered correlations between moral decision making and factors like age and type of institution where the committee operates. The results of this study also resemble those of previous studies in finding no correlation between ethics education and moral decision making. The author concludes that there is a need for more research on the effects of nonmoral personal, societal, and institutional factors on the moral reasoning of members of hospital ethics committees. Further, in the absence of any firm empirical basis, calls for ethics education for medical professionals and ethics committee members should be rethought.
ACUTE EFFECT OF INORGANIC IODIDE AFTER 131I THERAPY FOR HYPERTHYROIDISM

Patients treated with inorganic iodide weeks to years following 131I therapy for hyperthyroidism do not adapt to its antithyroid effect. To determine whether such adaptation occurs soon after 131I therapy, serum thyroxine (T4) and triiodothyronine (T3) concentrations were measured daily for 9-14 days following 131I therapy in seventeen hyperthyroid patients. Nine patients received 150 mg KI daily starting 48 h after 131I administration; eight received only 131I. Serum T4 and T3 concentrations did not change significantly in the patients who received only 131I. In the patients who received 131I and KI, serum T4 and T3 concentrations fell promptly, reaching nadir values 2-10 days after initiation of iodide, and then increased despite continuation of KI therapy. The mean maximal fall in serum T4 was 34% and in serum T3 42%. These results show that "escape" from the acute anti-thyroid effect of iodide occurs when it is given immediately after 131I therapy, thus limiting the utility of iodide as a therapeutic agent at this time.
Optical receiver and modulator frequency response measurement with a Nd:YAG ring laser heterodyn technique

A description is given of how the frequency response of optical receivers can be accurately calibrated by measuring a heterodyne signal generated by mixing two Nd:YAG ring lasers. One laser signal passes through the modulator while the other functions as a local oscillator to convert one of the sidebands of the modulated carrier to a fixed intermediate signal. This heterodyne system offers more than 50 dB of dynamic range. Calibration of both optical phase and amplitude modulators is achieved. The technique presented eliminates the need for a high-speed photoreceiver, has a good signal-to-noise ratio, and makes measurement of phase modulator frequency response possible. >
Influence of Flaw Shapes on Stress Intensity Factors for Pressure Vessel Surface Flaws and Nozzle Corner Cracks

The influence of the flaw shape on the variation of stress-intensity factors along the crack front is examined for longitudinal inner surface flaws in pressure vessels, and for corner cracks present at the intersection of a pressure vessel and a nozzle. For the inner surface flaw problem, the geometry of the pressure vessel considered is that of a commercial pressure vessel. The analyzed flaw shapes are those recom­ mended by the ASME Boiler and Pressure Vessel Code (Section III, App. G, 1977). In the case of corner cracks at nozzle-pressure vessel junctions, natural flaw shapes obtained through experiments are considered. A fully three-dimensional linear elastic hybrid displacement finite element procedure was used to analyze these problems of practical interest in pressure vessel analysis and design. The obtained solutions are compared with those in the literature using other numerical and/or experimental procedures, and a discussion of noted discrepancies is presented.
Computer-aided recipe generation for LPCVD reactors

A computer-aided-design (CAD) system which has been developed to assist the process engineer in choosing the best compromise between product and equipment performance is described. A formal, systematic methodology that facilities the task of recipe design for low pressure chemical-vapor-deposition (LPCVD) reactors is discussed. Recipe generation via interactive response surface exploration and automatic recipe generation via numerical optimization are discussed. >
Lorentz Covariant Quantization of Nonlinear Waves

The quantum theory of a real scalar field in one space dimension with quartic coupling is studied as an example of a field theory possessing exact classical solutions representing extended distributions of energy and momentum. It is shown how formal canonical quantization can be implemented in practice to obtain self-consistent, Lorentz-covariant descriptions of restricted portions of Hilbert space. This is done by deriving dynamical and kinematical sum rules from the equations of motion and commutation relations, respectively. These sum rules are shown to have a variational basis, which guarantees the consistency of the approach. Overall, we derive Lorentz-covariant generalizations of results found previously by Goldstone and Jackiw by using the same approach, as well as some new results. (AIP)
Complex motion pattern queries for trajectories

With the recent advancements and wide usage of location detection devices, large quantities of data are collected by GPS and cellular technologies in the form of trajectories. While most previous work on trajectory-based queries has concentrated on traditional range, nearest-neighbor and similarity queries, there is still the need to query trajectories using complex, yet more intuitive to users, motion patterns. In this paper, we describe several types of motion pattern queries for trajectories. In particular, we describe in detail two types of motion pattern queries: the flexible pattern queries, which focus on trajectories that follow a sequence of spatiotemporal events; and the density-based pattern queries, where the goal is to search trajectories that “stay together” for a long period of time. We then conclude this paper by briefly describing two other novel complex motion pattern queries that are currently under development.
EVIDENCE FOR PARALLEL ECOLOGICAL SPECIATION IN SCINCID LIZARDS OF THE EUMECES SKILTONIANUS SPECIES GROUP (SQUAMATA: SCINCIDAE)

We identify instances of parallel morphological evolution in North American scincid lizards of the Eumeces skiltonianus species group and provide evidence that this system is consistent with a model of ecological speciation. The group consists of three putative species divided among two morphotypes, the small-bodied and striped E. skiltonianus and E. lagunensis versus the large-bodied and typically uniform-colored E. gilberti. Members of the group pass through markedly similar phenotypic stages during early development, but differ with respect to where terminal morphology occurs along the developmental sequence. The morphotypes also differ in habitat preference, with the large-bodied gilberti form generally inhabiting lower elevations and drier environments than the smaller, striped morphs. We inferred the phylogenetic relationships of 53 skiltonianus group populations using mtDNA sequence data from the ND4 protein-coding gene and three flanking tRNAs (900 bp total). Sampling encompassed nearly the entire geographic range of the group, and all currently recognized species and subspecies were included. Our results provide strong evidence for parallel origins of three clades characterized by the gilberti morphotype, two of which are nested within the more geographically widespread E. skiltonianus. Eumeces lagunensis was also nested among populations of E. skiltonianus. Comparative analyses using independent contrasts show that evolutionary changes in body size are correlated with differences in adult color pattern. The independently derived association of gilberti morphology with warm, arid environments suggests that phenotypic divergence is the result of adaptation to contrasting selection regimes. We provide evidence that body size was likely the target of natural selection, and that divergences in color pattern and mate recognition are probable secondary consequences of evolving large body size.
Compositional patterning in immiscible alloys subjected to severe plastic deformation

Compositional patterning in two-phase immiscible alloys during severe plastic deformation at elevated temperatures has been investigated. Kinetic Monte Carlo computer simulations were used to test the proposed idea that patterning derives from a dynamic competition between homogenization by forced chemical mixing and phase separation by thermally activated diffusion [P. Bellon and R.S. Averback, Phys. Rev. Lett.74, 1819 (1995) and F. Wu et al., Acta Mater.54, 2605 (2006)]. We utilize the concept of pair diffusion coefficients to compare thermal diffusion with forced chemical mixing and discuss the fundamentally different behavior with respect to pair separation distance in both mechanisms. While the general ideas of this model are verified and are in good quantitative agreement with our simulations, it is found that the dynamic processes of alloys under high-temperature shear are very complex, even in highly idealized systems, making experimental verification of this model very difficult. We illustrate our findings for a model AB alloy with properties similar to Cu–Ag by showing how alloy morphology and solubility depend on shear rate, temperature, and composition.
IL-17–Mediated M1/M2 Macrophage Alteration Contributes to Pathogenesis of Bisphosphonate-Related Osteonecrosis of the Jaws

Purpose: Osteonecrosis of the jaw (ONJ) is emerging as one of the important complications in cancer patients treated with antiresorptive agents. This study explored the potential role of interleukin (IL)-17–mediated M1/M2 macrophage alterations in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). Experimental Design: The expression of IL-17 and M1 and M2 macrophage markers at the local mucosal site of human BRONJ lesions was examined by immunofluorescence studies. BRONJ-like disease was induced in C57BL/6 mice and multiple myeloma-burdened mice by intravenous injection of zoledronate to evaluate the correlation of elevated IL-17 levels with changes in M1 and M2 macrophage phenotypes and the therapeutic effects of blocking IL-17 on pathogenesis of BRONJ-like disease. Results: Increased T-helper (T H )17 cells and IL-17 cytokine correlate with an increase in M1/M2 macrophages ratio at the local mucosal site of both murine and human BRONJ lesion. Convincingly, in mice burdened with multiple myeloma, a combination of elevated suprabasal level and drug-induced IL-17 activity augmented the incidence of BRONJ; both systemic increase of IL-17 and disease severity could be reversed by adoptive transfer of ex vivo expanded M2 macrophages. Targeting IL-17 via specific neutralizing antibodies or a small inhibitory molecule, laquinimod, significantly decreased M1/M2 ratio and concomitantly suppressed BRONJ-like condition in mice. Mechanistically, IL-17 enhanced IFN-γ–induced M1 polarization through augmenting STAT-1 phosphorylation while suppressing IL-4–mediated M2 conversion via inhibiting STAT-6 activation. Conclusions: These findings have established a compelling linkage between activated IL-17–mediated polarization of M1 macrophages and the development of BRONJ-like conditions in both human disease and murine models. Clin Cancer Res; 19(12); 3176–88. ©2013 AACR .
Modeling a Horizontal Wiggler in an Electron Storage Ring

The effects of a wiggler on the beam parameters depend on several integrals involving the machine functions and the field distribution in the wiggler. It is shown that these integrals are separable into sums of products of terms containing only the initial values of the machine functions, and terms containing integrals over the wiggler fields. The field-dependent integrals may be determined by numerical integrations based on measured field distribution. In typical wiggler designs, the energy and excitation dependencies of the integrals may be modeled mathematically by simple power series.
Comparative Enzymology and Structural Biology of RNA Self-Cleavage

Self-cleaving hammerhead, hairpin, hepatitis delta virus, and glmS ribozymes comprise a family of small catalytic RNA motifs that catalyze the same reversible phosphodiester cleavage reaction, but each motif adopts a unique structure and displays a unique array of biochemical properties. Recent structural, biochemical, and biophysical studies of these self-cleaving RNAs have begun to reveal how active site nucleotides exploit general acid-base catalysis, electrostatic stabilization, substrate destabilization, and positioning and orientation to reduce the free energy barrier to catalysis. Insights into the variety of catalytic strategies available to these model RNA enzymes are likely to have important implications for understanding more complex RNA-catalyzed reactions fundamental to RNA processing and protein synthesis.
Regulation of MAP kinase by the BMP-4/TAK1 pathway in Xenopus ectoderm.

Abstract Bone morphogenetic protein-4 (BMP-4) induces epidermis and represses neural fate in Xenopus ectoderm. Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural induction. We have examined the effects of BMP-4 on MAPK activity in gastrula ectoderm. Expression of a dominant negative BMP-4 receptor resulted in a 4.5-fold elevation in MAPK activity in midgastrula ectoderm. MAPK activity was reduced in ectoderm expressing a constitutively active BMP-4 receptor, or ectoderm treated with BMP-4 protein in the presence or absence of cycloheximide. Overexpression of TAK1 led to a reduction in MAPK activity in early gastrula ectoderm. The inhibitory effects of TAK1 could be reversed by 1 μM SB 203580, a p38 inhibitor. Treatment of isolated ectoderm with SB 203580 led to expression of otx2, NCAM, and noggin. Western blot analyses indicated that the BMP-4 pathway does not activate JNKs in ectoderm. Our findings indicate that BMP-4 inhibits ectodermal MAPK activity through a TAK1/p38-type pathway. MAPK has been shown to inactivate Smad1. Thus, our results suggest that BMP-4 and MAPK pathways are mutually antagonistic in Xenopus ectoderm, and that interactions between these pathways may govern the choice between epidermal and neural fate.