cssi/SciSciGPT-SciSciNet huggingface dataset:
Fecundity Response of the Twospotted Spider Mite to Cotton Treated with Methyl Parathion or Phosphoric Acid

Adult females of Tetranychus urticae Koch were placed on cotton leaves (‘Acala SJ-2’) treated with methyl parathion (5E) or phosphoric acid (85%). The number of eggs deposited by F1 females was recorded daily and compared with mites ovipositing on untreated plants. Comparison of average daily oviposition and life tables statistics were made for each treatment on both field and greenhouse plants. In the field, mites on the methyl parathion-treated plants deposited a significantly ( P < 0.05) greater number of eggs for the first 4 days than those on the untreated plants. Mites on the phosphoric acid-treated plants deposited a significantly greater number of eggs on the second and third days than those on the untreated plants. Life table statistics paralleled the trends in increased population growth potentials for mites on the treated plants. Greenhouse results were less conclusive.
Crises During ECLS

Expeditious recognition and effective intervention during crises is essential to the successful management of patients receiving extracorporeal life support (ECLS). Crises during ECLS can be partitioned into those originating in the circuit and those originating in the patient. Circuit crises, such as the presence of circuit air, thrombosis, oxygenator failure, pump failure, tubing rupture, heater malfunction, and inadvertent decannulation, and patient crises such as bleeding, hemolysis, refractory hypoxemia, and shock, may quickly become life-threatening emergencies. Providers must be trained to promptly identify and respond to both common and uncommon complications of ECLS in order to optimize patient safety and improve clinical outcomes.
Study on Effeds of improvement of latrines in rural Areas

In order to understand the Effects of the projects of water and environmental sanitation on countryside economic performances improvement.90 sanitary latrines methods were tested on safe excreta disposal effectiveness,and testing of fertilizer efficiency of excrements were obtained from 9 three-compatments-type latrines and 7 double-urn-type latrines and single-urn-type(old-type) latrines.In the WES-performed counties,The Results Showed that A passing rate of 84.4% in terms of safe excreta disposal in sanitary latrines,a passing rate of 93.2% as for large intestinal germ value of excrement,and a passing rate of 91.1% as for rounderworm egg subsidy.Conclusion Sanitary latrines owes much to proper safe excreta disposal,the fertilizer efficiency of excrements from three-compatments-type latrines and double-urn-type latrines have a significantly higher improvement tha n those from single-urn-type(old-type) latrines,and thus to improve the economic performances of farming.
P-122 Spiritual care competencies of health care workers in slovakia

Background For many people the last phase of life rouses the question concerning to spiritual life. If medical workers like to enhance the quality of life of dying patients, palliative care should encompass whole personality of human being and its needs. Aim I like to share some outcomes from research on spiritual care competencies of health care workers in Slovakia arising from project KEGA034KU-4/2013: “Meeting the spiritual needs of dying patients in terms of health care workers in terms of practice”. Methods Survey – 447 Standardised Questionnaires – The Spiritual Care Competence Scale using five-level psychometric Likert scale Time: June 2014–July 2015 Place: Slovakia. Results processed by analysis of variance in its entirety as well as by individual domains. Results The overall average score for all participating health care workers is 3.72 – that means their competencies are high; Modus 4; Variance 1.31; standard deviation 1.13 and absolute deviation 0.92. Correlation with average score is significant at the p Statistically significant results in correlations in individual domains are to sex in five domains, to age in four domains and practice length in four domains. Conclusion Dying is not leaving cold those who are in the presence of dying. Health care workers should act in the best manner to achieve satisfaction of all needs, spiritual needs including. For that reason they must be well prepared and have the appropriate competencies.
On ‘Knowing one's self’ selfwriting, power and ethical practice: Reflections from an adult educator

AbstractAdult educators are increasingly concerned with issues of power and identity. Drawing on my research text, The Body's Tale, and Foucault's writings, I explore how pastoral power effects construct subjectivities in learners. Using three genealogical narratives from my text—eating, elimination and ‘swarming’—I show how we can interrupt our own self-regulation; I suggest we can surface our exercise of power in our daily work, and through self-writing, or askesis, the discipline and care of the self, develop an embodied ethical practice
Metastasectomy Following Immunotherapy with Adoptive Cell Transfer for Patients with Advanced Melanoma

Background Immunotherapeutic treatment strategies including adoptive cell transfer (ACT) for metastatic melanoma are capable of mediating complete and durable responses, as well as partial responses and prolonged disease stabilization. Unfortunately, many patients ultimately develop progressive disease. The role of salvage metastasectomy in managing these patients has not been evaluated.
Dynamic gait stability of treadmill versus overground walking in young adults

Treadmill has been broadly used in laboratory and rehabilitation settings for the purpose of facilitating human locomotion analysis and gait training. The objective of this study was to determine whether dynamic gait stability differs or resembles between the two walking conditions (overground vs. treadmill) among young adults. Fifty-four healthy young adults (age: 23.9±4.7years) participated in this study. Each participant completed five trials of overground walking followed by five trials of treadmill walking at a self-selected speed while their full body kinematics were gathered by a motion capture system. The spatiotemporal gait parameters and dynamic gait stability were compared between the two walking conditions. The results revealed that participants adopted a "cautious gait" on the treadmill compared with over ground in response to the possible inherent challenges to balance imposed by treadmill walking. The cautious gait, which was achieved by walking slower with a shorter step length, less backward leaning trunk, shortened single stance phase, prolonged double stance phase, and more flatfoot landing, ensures the comparable dynamic stability between the two walking conditions. This study could provide insightful information about dynamic gait stability control during treadmill ambulation in young adults.
The Lora Robins Gallery of Design from Nature: University of Richmond, Richmond, Virginia

(1985). The Lora Robins Gallery of Design from Nature. Rocks & Minerals: Vol. 60, No. 4, pp. 193-197.
Do Weak Interactions Become Strong at High Energy

Weak coupling theories in a semiclassical approximation lead to rapidly growing cross-sections coming from multiparticle production. In these lectures, I discuss two circumstances where such an approximation provides a sensible starting point: B + L violation in the standard electroweak theory and high order estimates in λφ4. Even though a rapidly growing cross-section may obtain for a limited energy range, such behaviour eventually must level off. Such a leveling off is hinted at by studying corrections to the semiclassical limit, and a general formalism for performing these corrections, due to Khlebnikov, Rubakov and Tyniakov, is explained. Because no closed form of the correction exists, however, the situation remains unclear. For the λφ4 theory, because of its Borel summability, one can show that the total cross-section at weak coupling is exponentially small. For the electroweak theory, however, a similar strong assertion cannot be made. Nevertheless, unitarity arguments, emphasized particularly by Zakharov and by Maggiore and Shifman, strongly hint that also B + L violation in the standard model will not grow strong at high energy, reaching at most a cross-section of order \(\frac{1}{s}{{e}^{{ - 2\pi /{{\alpha }_{\omega }}}}}\). Some of the caveats surrounding these conclusions are emphasized.
Effect of non-stoichiometry on the thermal and electrical properties of polycrystalline PtSb2 at low temperature

Abstract In narrow bandgap materials non-stoichiometry can dramatically change the measured electrical and thermal properties below room temperature. The work here attempts to examine the effects of non-stoichiometry on the low temperature properties of polycrystalline PtSb2. It was found that at antimony deficiencies of only 1% a change in the sign of the Seebeck coefficient was observed from 80 to 120 K. Further reduction of the antimony content resulted in a negative Seebeck for all temperatures measured. Antimony excess was found to retain positive values in the Seebeck coefficient, but with a reduction in the magnitude. The electrical resistivity was found to vary largely at low temperature, however converged to similar values at room temperature. These results show the importance of stoichiometry in narrow bandgap materials at low temperature.
Long-acting PDE5 inhibitor tadalafil prevents early doxorubicin-induced left ventricle diastolic dysfunction in juvenile mice: potential role of cytoskeletal proteins.

The chemotherapeutic use of doxorubicin (Dox) is hindered due to the development of irreversible cardiotoxicity. Specifically, childhood cancer survivors are at greater risk of Dox-induced cardiova...
Beauty and the burn: tanning and other appearance-altering attitudes and behaviors

Tanning is often prompted by appearance concerns, yet little is known about associations between tanning and other appearance-altering behaviors. In the current study, we examined potential correla...
The feral boy: archetypal image of pathos in a dream series

ABSTRACTThe figure of a half-human, half-feline boy appearing in a dream series of a middle-aged businessman suffering from job burnout is investigated from a Jungian perspective, noting its relevance to Jung’s concept of eros as a relatedness principle as well as an example of the puer aeternus or eternal child archetype. Further investigation into the feral boy figure reveals its compensatory function: a reaction to the dreamer’s regression to a more primitive state of self-identity and forced alienation from his business profession and his private life. Additional references to the feral boy from the Mesoamerican Olmec civilization provide evidence of the figure’s identity as an archetypal image of pathos, arousing sympathetic pity that leads to reconnecting the dreamer with his societal and familial responsibilities.
Pleiotropic Roles of Non-Coding RNAs in TGF-β-Mediated Epithelial-Mesenchymal Transition and Their Functions in Tumor Progression

Epithelial-mesenchymal transition (EMT) is a spatially- and temporally-regulated process involved in physiological and pathological transformations, such as embryonic development and tumor progression. While the role of TGF-β as an EMT-inducer has been extensively documented, the molecular mechanisms regulating this transition and their implications in tumor metastasis are still subjects of intensive debates and investigations. TGF-β regulates EMT through both transcriptional and post-transcriptional mechanisms, and recent advances underline the critical roles of non-coding RNAs in these processes. Although microRNAs and lncRNAs have been clearly identified as effectors of TGF-β-mediated EMT, the contributions of other atypical non-coding RNA species, such as piRNAs, snRNAs, snoRNAs, circRNAs, and even housekeeping tRNAs, have only been suggested and remain largely elusive. This review discusses the current literature including the most recent reports emphasizing the regulatory functions of non-coding RNA in TGF-β-mediated EMT, provides original experimental evidence, and advocates in general for a broader approach in the quest of new regulatory RNAs.
On subordination and linear transformation of harmonizable and periodically correlated processes

The problem of finding analytic conditions for subordination of harmonizable and periodically correlated sequences is studied. Sufficient conditions for subordination of harmonizable sequences (in the spirit of Kolmogorov’s work) and a simple counter-example showing that these conditions are not necessary are given. In the case of periodically correlated sequences, which is a subclass of harmonizable sequences, necessary and sufficient conditions for subordination, mutual subordination and necessary conditions for strong subordination of such processes in terms of their associated multivariate stationary sequences are derived. The problem of finding spectral conditions such that it is possible to find a mean-convergent series for a harmonizable sequence, when it is a linear transformation of another such sequence is studied. This idea is used to find an algorithm for the linear predictor and interpolator of a periodically correlated process in the time domain.
UV–Vis–IR spectral complex refractive indices and optical properties of brown carbon aerosol from biomass burning

Abstract Constraining the complex refractive indices, optical properties and size of brown carbon (BrC) aerosols is a vital endeavor for improving climate models and satellite retrieval algorithms. Smoldering wildfires are the largest source of primary BrC, and fuel parameters such as moisture content, source depth, geographic origin, and fuel packing density could influence the properties of the emitted aerosol. We measured in situ spectral (375–1047 nm) optical properties of BrC aerosols emitted from smoldering combustion of Boreal and Indonesian peatlands across a range of these fuel parameters. Inverse Lorenz–Mie algorithms used these optical measurements along with simultaneously measured particle size distributions to retrieve the aerosol complex refractive indices (m = n + iκ). Our results show that the real part n is constrained between 1.5 and 1.7 with no obvious functionality in wavelength (λ), moisture content, source depth, or geographic origin. With increasing λ from 375 to 532 nm, κ decreased from 0.014 to 0.003, with corresponding increase in single scattering albedo (SSA) from 0.93 to 0.99. The spectral variability of κ follows the Kramers-Kronig dispersion relation for a damped harmonic oscillator. For λ ≥ 532 nm, both κ and SSA showed no spectral dependency. We discuss differences between this study and previous work. The imaginary part κ was sensitive to changes in FPD, and we hypothesize mechanisms that might help explain this observation.
Silencing stemness in T cell differentiation

Functional diversity in multicellular organisms is achieved through the differentiation of stem cells. During this process, stem cells must retain both the capacity for self-renewal and the ability to differentiate into highly specialized cell types to produce a diverse array of tissues, each with distinct functions and organization. This plasticity is achieved through alterations to the epigenome, heritable and reversible modifications to DNA and histones that affect chromatin structure and gene transcription without altering the DNA sequence itself. Alterations to the epigenome enable cell type–specific transcriptional control that can change dynamically over the life of a cell. Such flexibility and responsiveness are instrumental in directing gene expression changes throughout cellular differentiation and lineage specification. The acquisition of more specialized functions during differentiation requires not only that the epigenome turn “on” genes involved in lineage commitment, it also necessitates that genes associated with stemness are simultaneously turned “off” ( 1 ). On page 177 of this issue, Pace et al. ( 2 ) demonstrate that this phenomenon exists in CD8+ T cells, in which epigenetic repression of stemness-associated genes by the histone methyltransferase SUV39H1 is required for T cell effector differentiation. Understanding these mechanisms addresses important questions in immunology and is applicable to cancer immunotherapy.
Abstract 20644: Association Between Sex Hormones and Ambulatory Blood Pressure

Introduction: Higher levels of free and total testosterone (TT) and lower levels of sex hormone binding globulin (SHBG) have been associated with increased blood pressure (BP) in women with an inverse association between TT and BP reported among men. Fewer studies have examined dehydroepiandrosterone sulfate (DHEAS) or the association between sex steroid hormones and 24-hr ambulatory blood pressure (ABP) or blunted nocturnal BP fall. Methods: Baseline blood samples were assayed for 267 normotensive racially diverse men (≥50 years) and women (≥55 years) participating in the VITamin D and OmegA-3 TriaL (VITAL). Standardized seated BP (systolic [SBP] and diastolic [DBP]) and 24-hr ABP were measured by trained technicians. All participants provided extensive baseline self-reported data on relevant cardiovascular risk factors and sociodemographic covariates. Linear regression models adjusted for age, sex, race, body mass index, smoking, alcohol, multivitamin use, and fruit and vegetable intake estimated the association between each sex hormone and measures of BP and 24-hr ABP separately by sex. We used logistic regression to estimate (OR, 95% CI) the association between each sex hormone and blunted nocturnal fall, defined as a >10% reduction in SBP or DBP during sleeping hours. Results: DHEAS, TT and SHBG were not significantly correlated with measures of BP when simultaneously adjusted for one another. In multivariable analyses stratified by sex, among women there was no association observed between sex hormones and measures of BP. Among men, each 10% increase in DHEAS was associated with a 0.45 mmHg increase in seated DBP (β=4.45, 95% CI: 0.71, 8.18) and each 10% increase in TT and SHBG was associated with a 0.67 mmHg (β=-6.73, 95% CI:-11.47, -1.99) and 0.72 mmHg (β=-7.23, 95% CI: -12.05, -2.41) decrease in seated DBP, respectively. Conclusions: We observed significant inverse cross-sectional associations between DHEAS, TT and SHBG with seated DBP in men, but not SBP, 24-hr ABP or blunted nocturnal BP. There was no association observed between sex hormones and measures of BP among women. Further research is needed to understand how sex hormones may impact BP measures over time.
A Temporal Topic Model for Noisy Mediums

Social media and online news content are increasing rapidly. The goal of this work is to identify the topics associated with this content and understand the changing dynamics of these topics over time. We propose Topic Flow Model (TFM), a graph theoretic temporal topic model that identifies topics as they emerge, and tracks them through time as they persist, diminish, and re-emerge. TFM identifies topic words by capturing the changing relationship strength of words over time, and offers solutions for dealing with flood words, i.e., domain specific words that pollute topics. An extensive empirical analysis of TFM on Twitter data, newspaper articles, and synthetic data shows that the topic accuracy and SNR of meaningful topic words are better than the existing state.
Why Governance Matters for Your Startup

Founders, investors, board members, employees and all participants in venture-backed companies should understand the basic principles of corporate governance. Different rules and practices will apply depending on the type of organization, ownership structure, stage of the company, investor base, size, geography or industry. In this article, we only focus on corporate governance for U.S. private venture-backed corporations. Specifically, we focus on the basic corporate governance framework for venture-backed companies and we address three governance issues: 1) the late stage “unicorn” phenomenon and its governance consequences, 2) conflicts of interests and “dual fiduciary conflicts”, and 3) multi-class share structures. As companies are “staying private for longer”, there should be an increased focus on governance of private venture-backed companies, particularly after a string of leading "unicorns" such as Uber, Theranos, Zenefits and SoFi, engaged in illegal and/or bad behavior that led to serious failures of culture, ethics and compliance. There has also been an uptick in private company lawsuits, particularly in Delaware, targeting poor governance practices in some venture-backed companies. “Growth at all costs” should no longer be the sole driving mantra of Silicon Valley and the technology startup industry. Boards of directors of venture-backed companies should take notice.
Working Mothers Represent: How Children Affect the Legislative Agenda of Women in Congress:

Issues and policies pertaining to children and families are often labeled “women’s issues” and assumed to be on the radar of all women, but we argue that they are more salient for mothers, particul...
Machine Learning Techniques for Security of Internet of Things (IoT) and Fog Computing Systems

The Internet of Things (IoT) is a network of interconnected computing devices having the ability to transfer data over a network, without needing human interaction. Software and communication technologies have seen a tremendous amount of growth in the past couple of decades, and this has resulted in a significant increase in IoT devices. Today, in 2017, IoT devices are ubiquitous and have pervaded almost every sphere of our lives ushering an era of 'smart things.' The explosive growth has resulted in much security and privacy concerns. The other concern is the scalability issue with the primary model of analyzing IoT data in the cloud. A cloud-only model leads to network congestion, data bottleneck and slower reaction times to security issues. By selectively moving computation and storage closer to the network edge, fog computing provides an effective solution for these issues. This paper presents a holistic picture of IoT, its growth, fog computing, and Machine Learning (ML) techniques for securing IoT devices and fog computing systems. It surveys ML techniques for detecting abnormalities and attacks, illustrates solutions to the data growth in IoT, and dives into the security issues concerning fog computing. It also discusses future research directions in this important topic.
More Useful Concepts for Containers

This chapter starts by showing how predicate logic constructs, such as ∀ (for all) and ∃ (there exists), can be formulated as ensemble methods for containers. Such methods are not really new since they can be derived from those already discussed. However, for efficiency reasons, it may be desirable to implement them as primitives in an OOP environment.
Time dependent correlations of entangled states with nondegenerate branches and possible experimental realization using singlet fission.

The spin-entangled exciton states produced by singlet fission provide an experimental route to generate entangled states with nondegenerate branches. Nondegenerate entangled pair states possess an internal “clock” that leads to quantum beating in various detected quantities. The implications of this internal clock for Bell’s inequality measurements and correlated particle detection are analyzed using two- and three-state spin models. In a Bell’s inequality experiment, we find that the choice of detection times can determine whether quantum or classical correlations are observed. The conditions under which the detection events could be time- or spacelike separated are analyzed in order to clarify how the temporal evolution of one particle can influence the time-dependent detection probability of the other. Possible routes to the detection of individual correlated triplet excitons are discussed, emphasizing both physical questions concerning the separation and propagation of triplet excitons over macroscopic distances and experimental challenges concerning decoherence, detection, and interpretation of the signals. We argue that spin-entangled triplet exciton states produced by singlet fission could provide a new way to probe entangled state detection and collapse, complementing schemes based on polarization-entangled photon states.
Prostate Cancer Detection Rate of Freehand versus 3-Dimensional Template Mapping Biopsy Using a Magnetic Resonance Imaging-Ultrasound Fusion Device in Biopsy Naïve Men

Purpose:Targeted prostate biopsy devices include a 3-dimensional digital template grid to guide systematic biopsy locations. Following a template could better ensure uniform and well distributed sa...
Improving Critical Listening skills in EMT Students

Introduction: Although the importance of EMT students utilizing critical listening skills is apparent, there is little research focused on EMT students or EMTs and critical listening. Ensuring EMT students develop critical listening skills can be an asset that reaches beyond the goal of improving their education. It also has the potential to improve the quality of care they go on to deliver. EMTs may have the only verbal contact with the patient while they are still conscious, or with bystanders that witnessed the incident, or family members/health aides that can give vitally important information on the patient’s condition. If an EMT is not adept at critical listening, vital information may be lost, and the repercussions can be serious. This project was designed to determine whether EMT student critical listening ability and class performance would improve from engaging in critical listening exercises. Methods: Critical listening exercises were emphasized during an EMT course by assessing student knowledge of the Patient Assessment module through two listening exercises modelled after the Ferrari, Lynch, and Vogel Listening Test that measures for critical listening skills. The Patient Assessment module was assessed twice within four weeks in a test-retest design. Results: The data analysis of a total of n = 51 students’ performance in the pre and post-assessments yielded positive results and showed students significantly improved their listening ability within the four-week period. An overall score increase of 34.50 % was found between the pre and the post assessment results. Moreover, the data analysis showed that as the result of the listening exercises, students scored significantly higher in the section of the certifying exam that included critical listening exercises than in all other sections. Conclusion: The results suggest performing critical listening exercises and assessments can help EMT students properly develop critical listening skills and improve performance.
Feasibility, Utility, and Limitations of a Rapid Community Behavioral Diagnosis for Social Distancing During the 2020 Coronavirus Pandemic.

Purpose:To evaluate the feasibility, utility, and limitations of a rapid community behavioral diagnosis (RCBD) for social distancing behaviors to prevent coronavirus transmission during a global co...
Forensic approaches to evaluating primary sources in internet history research: reconstructing early Web-based archival work (1989–1996)

This article examines early digital archival practices, especially those related to historical sources digitised and published to the World Wide Web in the 1990s. Without well-documented profession...
Survival benefit of lobectomy for glioblastoma: moving towards radical supramaximal resection

Extent of resection remains a paramount prognostic factor for long-term outcomes for glioblastoma. As such, supramaximal resection or anatomic lobectomy have been offered for non-eloquent glioblastoma in an attempt to improve overall survival. Here, we conduct a propensity-matched analysis of patients with non-eloquent glioblastoma who underwent either lobectomy or gross total resection of lesion to investigate the efficacy of supramaximal resection of glioblastoma. Patients who underwent initial surgery for gross total resection or lobectomy for non-eloquent glioblastoma at our tertiary care referral center from 2010 to 2019 were included for this propensity-matched survival analysis. Propensity scores were generated with the following covariates: age, location, preoperative KPS, product of perpendicular maximal tumor diameters, and product of perpendicular FLAIR signal diameters. Inverse probability of treatment weighting (IPTW) with generated propensity scores was used to compare progression-free survival and overall survival. Sixty-nine patients were identified who underwent initial resection of glioblastoma for non-eloquent glioblastoma from 2010 to 2019 (GTR = 37, lobectomy = 32). Using IPTW, overall survival (30.7 vs. 14.1 months) and progression-free survival (17.2 vs. 8.1 months were significantly higher in the lobectomy cohort compared to the GTR group (p < 0.001). There was no significant difference in pre-op or post-op KPS or complication rates between the two groups. Our propensity-matched study suggests that lobectomy for non-eloquent glioblastoma confers an added survival benefit compared to GTR alone. For patients with non-eloquent glioblastoma, a supramaximal resection by means of an anatomic lobectomy should be considered as a primary surgical treatment in select patients if feasible.
Chirality-Dependent Second Harmonic Generation of MoS2 Nanoscroll with Enhanced Efficiency.

Materials with high second harmonic generation (SHG) efficiency and reduced dimensions are favorable for integrated photonics and nonlinear optical applications. Here, we fabricate MoS2 nanoscrolls...
Safety of bone marrow aspiration and biopsy in severely thrombocytopenic patients

To assess the safety of fluoroscopically guided drill-assisted bone marrow aspirate and biopsy in severely thrombocytopenic patients. The study was approved by the IRB with waiver of informed consent. Retrospective review of 111 bone marrow aspirate and biopsies (BMAB) performed in 94 patients who received a CT scan which included the pelvis and biopsy site within the 7 days following the BMAB. The 94 patients were subdivided based on their platelet count: severe thrombocytopenia ( 50 platelets × 109/L). The procedure report was reviewed for sedation time, aspirate volume, and aggregate size of core biopsy specimens. The electronic medical record was reviewed for specimen adequacy; pathologic diagnosis; body mass index; pre- and post-procedure labs including platelet count, hemoglobin (HGB), hematocrit (HCT), prothrombin time (PT), and international normalized ratio (INR) levels; post-procedural transfusion; and complications including mortality at 30 and 90 days. CT scans were independently reviewed by 2 fellowship-trained radiologists for the presence of post-procedural hemorrhage. There was no significant difference in CT-identified post-procedural hematoma, or change in the hemoglobin and hematocrit levels pre- and post-procedure between the three groups. There was no significant difference in complication rate or all-cause mortality. There was a significant difference in transfusion at 30 days with thrombocytopenic and severely thrombocytopenic patients more likely to receive transfusion within the 30 days post-procedure. Fluoroscopically guided BMAB can be safely performed in patients with severe thrombocytopenia.
A multi-stage stochastic programming approach to epidemic resource allocation with equity considerations

Existing compartmental models in epidemiology are limited in terms of optimizing the resource allocation to control an epidemic outbreak under disease growth uncertainty. In this study, we address this core limitation by presenting a multi-stage stochastic programming compartmental model, which integrates the uncertain disease progression and resource allocation to control an infectious disease outbreak. The proposed multi-stage stochastic program involves various disease growth scenarios and optimizes the distribution of treatment centers and resources while minimizing the total expected number of new infections and funerals. We define two new equity metrics, namely infection and capacity equity, and explicitly consider equity for allocating treatment funds and facilities over multiple time stages. We also study the multi-stage value of the stochastic solution (VSS), which demonstrates the superiority of the proposed stochastic programming model over its deterministic counterpart. We apply the proposed formulation to control the Ebola Virus Disease (EVD) in Guinea, Sierra Leone, and Liberia of West Africa to determine the optimal and fair resource-allocation strategies. Our model balances the proportion of infections over all regions, even without including the infection equity or prevalence equity constraints. Model results also show that allocating treatment resources proportional to population is sub-optimal, and enforcing such a resource allocation policy might adversely impact the total number of infections and deaths, and thus resulting in a high cost that we have to pay for the fairness. Our multi-stage stochastic epidemic-logistics model is practical and can be adapted to control other infectious diseases in meta-populations and dynamically evolving situations.
A Pilot Randomized Controlled Trial of Online-Delivered ACT-Enhanced Behavior Therapy for Trichotillomania in Adolescents

Abstract Treatment of adolescent trichotillomania is understudied, and treatment providers are difficult to find. In this pilot study, we compared ACT-enhanced behavior therapy to a waitlist, with treatment delivered over Zoom, to 28 adolescents who met criteria for trichotillomania. This study partially occurred during the COVID-19 pandemic. A detailed description of the treatment protocol is provided for ACT-enhanced behavior therapy adapted to a Zoom format for adolescents. Pretreatment assessments were completed over Zoom by an assessor unaware of study condition; pretreatment and posttreatment questionnaires were completed online. Results indicated that therapy was delivered with fidelity and competence over Zoom, with 100% session completion. Adolescents reported that pulling severity decreased significantly more in the treatment condition than waitlist. No differences were seen in other adolescent or parent-reported pulling severity or distress. However, significant medium to large within-condition effect sizes were observed in the treatment condition. Medium effect size changes were seen in the treatment group on a measure of trichotillomania-related psychological flexibility, and a small effect size was seen for psychological distress. Overall, pilot results provide preliminary support for ACT-enhanced behavior therapy, delivered over Zoom, for adolescent trichotillomania, indicating the need for a fully powered confirmatory efficacy trial.
Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice

It is imperative to develop novel therapeutic strategies for Alzheimer's disease (AD) and related dementia syndromes based on solid mechanistic studies. Maintenance of memory and synaptic plasticity relies on de novo protein synthesis, which is partially regulated by phosphorylation of eukaryotic elongation factor 2 (eEF2) via its kinase eEF2K. Abnormally increased eEF2 phosphorylation and impaired mRNA translation have been linked to AD. We recently reported that prenatal genetic suppression of eEF2K is able to prevent aging-related cognitive deficits in AD model mice, suggesting the therapeutic potential of targeting eEF2K/eEF2 signaling in AD. Here, we tested two structurally-distinct small-molecule eEF2K inhibitors in two different lines of AD model mice after onset of cognitive impairments. Our data revealed that treatment with eEF2K inhibitors improved AD-associated synaptic plasticity impairments and cognitive dysfunction, without altering brain amyloid (A{beta}) and tau pathology. Furthermore, eEF2K inhibition alleviated AD-associated defects in dendritic spine morphology, postsynaptic density formation, protein synthesis, and dendritic polyribosome assembly. Our results may offer critical therapeutic implications for AD, and the proof-of-principle study indicates translational implication of inhibiting eEF2K for AD and related dementia syndromes.
Galleon Anxiety: How Afro-Mexican Women Shaped Colonial Spirituality in Acapulco

Acapulco became a global town during the early seventeenth century, characterized not only by transpacific trade, but also by an increasingly large Afro-Mexican population residing and laboring at the port. A cohort of Afro-Mexican women gained prominence and visibility by delivering accurate predictions on the arrival of galleons to Acapulco. They adapted mixed African and Indigenous divination practices to calm port residents worried about galleon losses on the world's largest ocean. Scholarship on the Spanish Pacific has yet to investigate how the globalization of New Spain through galleon travel affected African and Afro-descendant communities. This article contends that the dangers of Pacific travel, and anxieties about them, frequently exceeded the therapeutic capacities of Catholic dogma. Black women, drawing on the profound West and West Central African estimation of female diviners, practiced clairvoyance to report on the location of galleons and whether they would arrive safely. The confluence of an increasing population of Afro-Mexicans with the economic dynamism of transpacific trade transformed spiritual life at the eastern node of Spain's Pacific empire. Black women positioned themselves at the center of these massive structural transformations and ultimately created new cultures as spiritual authorities in Acapulco.
Evaluation and management of biliary complications after pediatric liver transplantation: pearls and pitfalls for percutaneous techniques

In pediatric liver transplantation, bile duct complications occur with a greater incidence than vascular anastomotic dysfunction and represent a major source of morbidity and mortality. While surgical re-anastomosis can reduce the need for retransplantation, interventional radiology offers minimally invasive and graft-saving therapies. The combination of small patient size and prevailing Roux-en-Y biliary enteric anastomotic techniques makes endoscopic retrograde cholangiopancreatography difficult if not impossible. Expertise in percutaneous management is therefore imperative. This article describes post-surgical anatomy, pathophysiology and noninvasive imaging of biliary complications. We review percutaneous techniques, focusing heavily on biliary access and interventions for reduced liver grafts. Subsequently we review the results and adverse events of these procedures and describe conditions that masquerade as biliary obstruction.
The Politics and Security of the Gulf: Anglo-American Hegemony and the Shaping of a Region

1. Great Britain's Legacy in the Persian Gulf 2. World War II and the Arrival of the Americans 3. The Early Cold War, the Loss of India, and Nasser's Revolt Against the British, 1946-1958 4. The British Position in the Gulf under Assault 5. America Watches as the British Birth a New Gulf Order, 1968-1971 6. The Chaotic Interregnum: America Cries Enough, 1972-1991 7. Pax Americana - Bellum Americanum, 1991-present. Conclusion
Abstract P4-14-09: The effect of socioeconomic status and race on breast cancer tumour biology and stage at diagnosis

Introduction: Mortality from breast cancer has declined over the last 2 decades. However, not all racial groups have benefited equally. African American women continue to die from breast cancer at higher rates than do white women. While racial disparities exist in breast cancer outcomes, they may largely be explained by socioeconomic factors. The effect of poverty on more aggressive breast cancer has not been well studied. We evaluated the association of race, insurance, and age on breast cancer stage and tumour biology within an urban inner city safety net hospital. Methods: A retrospective review of a prospective breast cancer database was used to identify 535 women with stage 0 to IV breast cancer seen at UF Health Jacksonville from the period January 2009-March 2013. Age, race and insurance status at the time of diagnosis were used as covariates for defining disparities in stage at diagnosis and tumour biology. Tumour profile was defined as four groups: luminal A (ER+, PR+, HER-2 neg), luminal B (ER+, PR neg, HER-2 neg), HER-2/neu positive, and triple negative. Insurance categories were defined as Commercial, Medicare, Medicaid/Charity. Results: There was equal racial distribution between African American (47.3%) and white women (47.5%) with 5.2 % other races. A relatively large number of patients had Medicaid/Charity coverage (37.1%), followed by Medicare at 32.7 %, and 30.3 % had commercial insurance. The mean age was 58.8 (SD=12.9). There was no significant association between race and stage at diagnosis within our patient population (p=0.869). However, women with Medicaid/Charity coverage were diagnosed at more advanced stage compared to women with other insurnace (adjusted p-value Conclusion: UF Health Jacksonville encounters a uniquely equal racial distribution of women with breast cancer. Within our population, women with lower socioeconomic status based on insurance type present with more advanced stage at diagnosis independent of race. Black race and Medicaid/Charity coverage was significantly associated with more aggressive tumour biology. These results suggest that socioeconomic factors may have a significant influence on the breast cancer disease process and may contribute to racial disparities in breast cancer outcomes. Citation Format: Priya Sharma, Dale F Kraemer, Sarah M Osian, Carmen Smotherman, Mia Vincent, Laila Samiian. The effect of socioeconomic status and race on breast cancer tumour biology and stage at diagnosis [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-14-09.
Bone marrow mesenchymal stromal cells to treat tissue damage in allogeneic stem cell transplant recipients: correlation of biological markers with clinical responses.

Bone marrow mesenchymal stromal cells (BMSCs) have been used to treat acute graft-versus-host disease (GVHD) and other complications following allogeneic hematopoietic stem cell transplantation (SCT). We conducted a phase I trial using third party, early passage BMSCs for patients with steroid-refractory GVHD, tissue injury, or marrow failure following SCT to investigate safety and efficacy. To identify mechanisms of BMSC immunomodulation and tissue repair, patients were serially monitored for plasma GVHD biomarkers, cytokines, and lymphocyte phenotype. Ten subjects were infused a fixed dose of 2 × 106 BMSCs/kg intravenously weekly for three doses. There was no treatment-related toxicity (primary endpoint). Eight subjects were evaluable for response at 4 weeks after the last infusion. Five of the seven patients with steroid-refractory acute GVHD achieved a complete response, two of two patients with tissue injury (pneumomediastinum/pneumothorax) achieved resolution but there was no response in two subjects with delayed marrow failure. Rapid reductions in inflammatory cytokines were observed. Clinical responses correlated with a fall in biomarkers (Reg 3α, CK18, and Elafin) relevant for the site of GVHD or tissue injury. The GVHD complete responders survived significantly longer and had higher baseline absolute lymphocyte and central memory CD4 and CD8 counts. Cytokine changes also segregated with survival. These results confirm that BMSCs are associated with rapid clinical and biomarker responses in GVHD and tissue injury. However, BMSCs were ineffective in patients with prolonged GVHD with lower lymphocyte counts, which suggest that effective GVHD control by BMSCs requires a relatively intact immune system. Stem Cells 2014;32:1278–1288
Reframing the Debate on Language Separation: Toward a Vision for Translanguaging Pedagogies in the Dual Language Classroom

The policy of strict separation of languages for academic instruction dominates dual language bilingual education programming. This article explores the dynamic bilingual practices of two experienced bilingual teachers in a two-way dual language public school in Texas and contributes to current research problematizing language separation. Data included interviews, field notes, and classroom interaction video in a pre-kindergarten and a first grade classroom. The instructional practices of the two teachers suggested powerful strategies to promote bilingual identities. Drawing on identity theory, particularly the notions of positioning and investment, we attempt to contribute to recent research offering teachers potential translanguaging instructional strategies. These strategies include: (a) modeling dynamic bilingual language practices, (b) positioning students as bilingual (even before they are), and (c) celebrating and drawing attention to language crossing. In combining these strategies, teachers move toward using students' bilingual language practices as a resource for academic instruction. [ABSTRACT FROM AUTHOR]
Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors

We studied whether several modifiable factors were associated with the risk of total hip replacement due to hip osteoarthritis among women.We identified 568 women from the Nurses' Health Study who reported total hip replacement due to primary hip osteoarthritis on questionnaires from 1990 to 1996, using a validated algorithm. The relation of potential risk factors, such as age, body mass index, physical activity, smoking, alcohol intake, and hormone use, to hip replacement was assessed using pooled logistic regression models. Higher body mass index was associated with an increased risk of hip replacement due to osteoarthritis (P for trend = 0.0001). Compared with women in the lowest category of body mass index ( or =35 kg/m(2)) had a twofold increased risk (95% confidence interval [CI]: 1.4 to 2.8), whereas those in the highest category of body mass index at age 18 years had more than a fivefold increased risk (95% CI: 2.5 to 10.7). Age also had a positive association; women aged > or =70 years were nine times more likely to have hip replacement than those aged <55 years (95% CI: 5.4 to 13.9). Recreational physical activity, smoking, alcohol use, and postmenopausal hormone use were not associated with an increased risk of hip replacement. In the Nurses' Health Study, higher body mass index and older age significantly increased the risk of total hip replacement due to osteoarthritis. Part of this risk appeared to be established early in life.
COMPARISON OF COVERT REINFORCEMENT, COVERT ASSERTION, AND OVERT REINFORCEMENT IN CHANGING EXTERNAL LOCUS OF CONTROL

This study compared the effectiveness of covert reinforcement, overt reinforcement, and covert assertion in modifying locus of control. The I-E scale was administered to 40 subjects who were then randomly assigned to one of five treatment groups: covert reinforcement (response irrelevant) for self-statements reflecting internality, overt reinforcement for internal statements, covert assertion of internal statements, attention control, and no-treatment control. The 1-E scale was given after treatment and at a 2-wk. follow-up. Data showed that overt reinforcement and covert assertion tended to increase internality, but that response irrelevant covert reinforcement and control instructions did not.