cssi/SciSciGPT-SciSciNet huggingface dataset:
Blood Pressure in Native Americans Switched from Celecoxib to Rofecoxib

BACKGROUND:Nonsteroidal antiinflammatory drugs have been associated with exacerbation of hypertension. Differing effects on blood pressure (BP) have been reported in studies comparing celecoxib and rofecoxib. Concern regarding the cardiovascular safety of the cyclooxygenase-2 (COX-2) inhibitor class has intensified since the removal of rofecoxib from the market.OBJECTIVE:To evaluate the effect of a formulary change from celecoxib to rofecoxib on the BP of Native American patients at an Indian Health Service medical center.METHODS:Medical records of patients switched from celecoxib to rofecoxib were retrospectively reviewed. BP during the respective treatments was compared as follows: measurements recorded while taking celecoxib within 6 months before the index date and while taking rofecoxib from 1 week after the index date through 6 months of treatment were averaged. Differences in systolic and diastolic BP before and after the therapy change were evaluated using a paired Student's t-test. Subgroup analy...
Sampled data control of large space structures using constant gain velocity feedback: A negative view

A framework is developed for sampled data control of large space structures, in terms of discrete time recursive equations in second order form. This framework is used to analyze the simplest control scheme where the loop is closed using constant gain output velocity feedback. It is shown that the closed loop is stable if the feedback gain is positive definite and not too large, and if the output velocity feedback is properly specified. Properties of such a stabilizing controller establish the advantage of analog control of the form considered.
Effects of recreational clam harvesting on eelgrass (Zostera marina) and associated infaunal invertebrates: in situ manipulative experiments

Abstract The effect of recreational clam harvesting on eelgrass (Zostera marina L.) was experimentally tested by raking or digging for clams in experimental 1 m2 plots located in a Yaquina Bay (Newport, OR) eelgrass meadow. After three monthly treatments, eelgrass measures of biomass, primary production (leaf elongation), and percent cover were compared between experimental and control (undisturbed) plots. Benthic macro (retained on 0.5 mm mesh sieve) and mega (retained on 3 mm sieve) infaunal samples were also taken to compare species number and abundances. Results indicated that clam raking did not appreciably impact any measured parameter. In contrast, clam digging reduced eelgrass cover, above-ground biomass and below-ground biomass in measurements made 1 month after the last of three monthly treatments. Although differences between control and treatment plots persisted 10 months after the last clam digging treatment, these differences were not statistically significant. Approximately 10% of the eelgrass of Yaquina Bay is subjected to recreational clamming and as this activity is generally less intense than that employed in this study, it is unlikely that recreational clamming has a major impact on eelgrass beds in the Yaquina estuary. This conclusion should be viewed with caution as multi-year disturbances were not investigated and there are differences in sediment characteristics and clam abundances between experimental sites and those sites that are intensively harvested by the public.
Endoscopy in inflammatory bowel disease.

Abstract With the heterogeneous clinical presentation of IBD, endoscopy plays an integral role in the initial diagnosis of ulcerative colitis and Crohn's disease. Although radiographic tests often are supplemental in the work-up of IBD, colonoscopy with biopsy is the test of choice if IBD is suspected and is more sensitive than radiographic tests. Endoscopic features can be helpful in differentiating ulcerative colitis and Crohn's disease. Currently the only mode for detecting dysplasia and stratifying the risk of developing colorectal cancer is through complete colonoscopy with multiple biopsy specimens. Complications of IBD can be managed effectively with endoscopic therapy. The role of endoscopic ultrasound and future developments in endoscopic therapy need to be defined by future studies.
Implementation of an Adaptive Visually-Guided Neural Controller for Single Postures

A neural network model has been developed that achieves adaptive visual-motor coordination of a multijoint arm, without a teacher. The model has been computer simulated to adaptively position an arm so that it reaches a cylinder arbitrarily positioned in space. The model uses a new neural architecture and a new algorithm for modifying neural-connection strengths. A simpler version of the model has also been implemented with an industrial image processing system and an industrial robot arm to adaptively reach in space. The neural model called INFANT is designed to be generalized for coordinating any number of topographic sensory inputs with limbs of any number of joints. The general scheme of the neural model is also proposed.
Synthesis and DNA binding properties of a cationic 2,2':6',2"-terpyridine cobalt(II) complex containing an oligopeptide.

Abstract The first example of DNA metallointercalator containing an oligopeptide moiety is presented. The ternary cobalt(II) complex [(DOTA)Co(II)(TPY)](ClO4)2 (DOTA=1,4,7,10-tetraaza-cyclododecane-2,9-dione, TPY=2, 2′:6′,2″-terpyridine) was found to be efficient in binding ct-DNA. The binding constant was determined by spectrophotometric titration. In vitro antitumor studies shows that this complex has significant antitumor activity. The single-crystal of a six coordinated oligopeptide cobalt(II) complex [Co(II)(DOTA)2](ClO4)2 is also reported. The stabilities and species distributions of Co(II)–DOTA (1:1) and DOTA–Co(II)–TPY (1:1:1) systems were investigated by potentiometry titration.
Physical Characterization of Thin Films of Lithium Niobate Deposited on Silicon Substrates

Thin films (.1−.6 lam) of LiNbO3 have been deposited on silicon substrates by reactive rf sputtering. Under optimized deposition conditions the resulting thin films of LiNbO3 were optically transparent, adhered well to the silicon substrates, and were found to be polycrystalline and uniaxial with the c axis oriented normal to the silicon surface. Optical microscopy and scanning electron microscopy were used to examine film morphology. Both methods indicated that the films were smooth and contained no gross irregularities. The ratio of oxygen to niobium in these films was measured by Rutherford backscattering to be approximately 3 to 1. Auger electron spectroscopy depth profiling revealed that the films had the expected ratio of Li, Nb, and O. This information, together with Bragg x-ray diffraction data, indicates that the thin films deposited on silicon were stoichiometric, crystalline LiNbO3
Deer Forage Response to Herbicide and Fire in Mid-Rotation Pine Plantations

Mid-rotation management practices for pine (Pinus spp.) plantations enrolled in cost-share programs have not been widely evaluated for wildlife. Mid-rotation pine plantations often have a substantial hardwood mid-story that limits growth of desirable understory forage species important to white-tailed deer (Odocoileus virginianus; deer). We treated with imazapyr herbicide and prescribed burning (HB) 11 thinned, 13–22-year-old loblolly pine (P. taeda) plantations in the Upper Coastal Plain (UCP; n = 5) and the Lower Coastal Plain (LCP; n = 6) of Mississippi, USA, enrolled in cost-share programs. We then sampled these plantations for production of important deer forages during July of 2003 and 2004, years 1 and 2 posttreatment. Deer foraging habitat was clearly improved by the HB treatment in both regions by year 2. Forb species of annual importance to deer increased in percent cover and biomass in the UCP and in biomass in the LCP. We estimated nutritional carrying capacity using a target diet quality of 14% crude protein; estimates in HB plots were 3 times greater than controls in the UCP and 19 times greater in the LCP. Although UCP sites had baseline carrying capacities nearly 8 times greater than LCP sites, the greater relative response to HB in the LCP eliminated the regional difference. Our results indicate that imazapyr herbicide treatment followed by prescribed fire is a beneficial tool for deer management in mid-rotation pine plantations.
Broadcast capacity in multihop wireless networks

In this paper we study the broadcast capacity of multihop wireless networks which we define as the maximum rate at which broadcast packets can be generated in the network such that all nodes receive the packets successfully in a limited time. We employ the Protocol Model for successful packet reception usually adopted in network capacity studies and provide novel upper and lower bounds for the broadcast capacity for arbitrary connected networks. In a homogeneous dense network these bounds simplify to Θ(W/max(1,Δd)) where W is the wireless channel capacity, Δ the interference parameter, and d the number of dimensions of space in which the network lies. Interestingly, we show that the broadcast capacity does not change by more than a constant factor when we vary the number of nodes, the radio range, the area of the network, and even the node mobility. To address the achievability of capacity, we demonstrate that any broadcast scheme based on a backbone of size proportional to the Minimum Connected Dominating Set guarantees a throughput within a constant factor of the broadcast capacity. Finally, we demonstrate that broadcast capacity, in stark contrast to unicast capacity, does not depend on the choice of source nodes or the dimension of the network.
Saturated control of an uncertain nonlinear system with input delay

This paper examines saturated control of a general class of uncertain nonlinear systems with time-delayed actuation and additive bounded disturbances. The bound on the control is known a priori and can be adjusted by changing the feedback gains. A Lyapunov-based stability analysis utilizing Lyapunov-Krasovskii (LK) functionals is provided to prove uniformly ultimately bounded tracking despite uncertainties in the dynamics. A numerical example is presented to demonstrate the performance of the controller.
Adverse events in acute care: An integrative literature review

An integrative literature review was conducted to investigate studies on adverse events reported in medical, health services, and nursing literature. The review was guided by the method proposed by Jackson (1980) and Ganong (1987). Three questions shaped the review: (a) What terms are used to denote adverse events? (b) What purposes drive adverse events research? and (c) What data sources are used to study adverse events? Adverse events was the dominant term, the study of adverse events as an outcome variable was the prevailing research purpose, and monitoring or screening the patient clinical record and self-reported incidents by health care professionals were the main data sources. Future research is recommended to conceptualize and study adverse events.
Effect of Mental Practice Combined with Physical Practice on Balance in the Community-Dwelling Elderly

Abstract Objectives. This study is designed to test the effects of a 6-week trial of mental practice of motor imagery (MP) on balance and gait in community-dwelling elderly. Methods. Six elderly females were recruited from a community-assisted living center and randomly assigned 2 groups. The experimental group received 20 minutes of mental practice of motor imagery, while the control group received 20 minutes of health education, before assembling together for 20 minutes of physical exercise. The study lasted for 6 weeks, 12 intervention sessions, with each intervention session lasting for 1 hour. Pretest-Posttest outcome measures included the Berg Balance Scale (BBS), Timed Up and Go (TUG), and Activities-specific Balance Confidence Scale (ABC). Results. Compliance was excellent. Wilcoxon Signed-Ranks test for the TUG were significant (Z = 2.2, p = .02) for increases in gait speed for the group as a whole. Improvements were measured in dynamic measures of balance on the BBS, but all outcome measures wer...
A CONCEPTUAL MODEL OF ECOLOGICAL INTERACTIONS IN THE MANGROVE ESTUARIES OF THE FLORIDA EVERGLADES

A brackish water ecotone of coastal bays and lakes, mangrove forests, salt marshes, tidal creeks, and upland hammocks separates Florida Bay, Biscayne Bay, and the Gulf of Mexico from the freshwater Everglades. The Everglades mangrove estuaries are characterized by salinity gradients that vary spatially with topography and vary seasonally and inter-annually with rainfall, tide, and freshwater flow from the Everglades. Because of their location at the lower end of the Everglades drainage basin, Everglades mangrove estuaries have been affected by upstream water management practices that have altered the freshwater heads and flows and that affect salinity gradients. Additionally, interannual variation in precipitation patterns, particularly those caused to El Nino events, control freshwater inputs and salinity dynamics in these estuaries. Two major external drivers on this system are water management activities and global climate change. These drivers lead to two major ecosystem stressors: reduced freshwater flow volume and duration, and sea-level rise. Major ecological attributes include mangrove forest production, soil accretion, and resilience; coastal lake submerged aquatic vegetation; resident mangrove fish populations; wood stork (Mycteria americana) and roseate spoonbill (Platelea ajaja) nesting colonies; and estuarine crocodilian populations. Causal linkages between stressors and attributes include coastal transgression, hydroperiods, salinity gradients, and the “white zone” freshwater/estuarine interface. The functional estuary and its ecological attributes, as influenced by sea level and freshwater flow, must be viewed as spatially dynamic, with a possible near-term balancing of transgression but ultimately a long-term continuation of inland movement. Regardless of the spatio-temporal timing of this transgression, a salinity gradient supportive of ecologically functional Everglades mangrove estuaries will be required to maintain the integrity of the South Florida ecosystem.
Interaction of the serine hydrolase KIAA1363 with organophosphorus agents: Evaluation of potency and kinetics.

Oxons are bioactive metabolites of organophosphorus insecticides (OPs) that covalently inactivate serine hydrolases. KIAA1363 is one of the most abundant serine hydrolases in mouse brain. Although the physiological consequences related to the inhibition of KIAA1363 due to environmental exposures to OPs are poorly understood, the enzyme was previously shown to have a role in the detoxification of oxons. Here, we overexpressed human KIAA1363 and CES1 in COS7 cells and compared the potency of inhibition (IC50s, 15 min) of KIAA1363 and CES1 by chlorpyrifos oxon (CPO), paraoxon (PO), and methyl paraoxon (MPO). The order of potency was CPO > PO >> MPO for both enzymes. We also determined the bimolecular rate constants (kinact/Ki) for reactions of CPO and PO with KIAA1363 and CES1. KIAA1363 and CES1 were inactivated by CPO at comparable rates (4.4 × 10(6) s(-1) M(-1) and 6.7 × 10(6) s(-1) M(-1), respectively), whereas PO inactivated both enzymes at slower rates (0.4 × 10(6) s(-1) M(-1) and 1.5 × 10(6) s(-1) M(-1), respectively). Finally, the reactivation rate of KIAA1363 following inhibition by CPO was evaluated. Together, the results define the kinetics of inhibition of KIAA1363 by active metabolites of agrochemicals and indicate that KIAA1363 is highly sensitive to inhibition by these compounds.
Book Review: The Medical Malpractice Myth

The Author reviews THE MEDICAL MALPRACTICE MYTH by Tom Baker, published by University of Chicago Press, 2005. Baker’s book confronts the idea that medical malpractice litigation is exploding and underserving plaintiffs and that their attorneys receive unjustified rewards while physicians struggle under the burden of high costs. The book strives to debunk the various aspects of this myth and offers directions for reform. Throughout the book, Baker very effectively connects the legal arguments and the insurance and litigation data to his broader points about the politics of tort reform. Baker’s style is concise, lively, and very readable. He effectively weaves in the personal stories of particular plaintiffs to illustrate many of his broader points. The book is aimed at and accessible to a general audience, but it will also prove interesting and informative to lawyers, and to legal, medical and public health academics. Although his thesis likely would be less surprising to the latter groups, Baker’s careful construction and support of his argument makes a valuable contribution to the malpractice debate in academia. It can also serve as a fine secondary source in law school or public health courses on insurance law or medical malpractice. Even those readers who disagree with Baker’s argument and his conclusions will find the book informative and helpful in strengthening their understanding of the law and politics of the malpractice debate.
Comparison of clinical outcomes between two meropenem dosing strategies in an obese population

None of the authors have any disclosures. • Carbapenems are broad-spectrum antibiotics that demonstrate time dependent, bactericidal activity against both Gram-positive and Gram-negative pathogens. − The target pharmacodynamic index for carbapenems is a free drug concentration above the minimum inhibitory concentration (MIC) for approximately 40% of the dosing interval (~40%fT>MIC)1-6 • Pharmacokinetic/pharmacodynamic (PKPD) studies have demonstrated similar target attainment rates (>40fT>MIC) between the conventional meropenem dosing strategy (1g IV every 8 hours) and an alternative dosing strategy (500mg IV every 6 hours) 1-3 − Differences in meropenem PK properties have been identified in obese patients4-6 • Clinical studies have demonstrated similar patient outcomes and increased cost savings with the alternative meropenem dosing strategy as compared with the traditional dosing approach1-3 − Limited clinical outcomes data are currently available comparing the two meropenem dosing strategies in obese patients4-6 • Given the rise in antimicrobial resistance and the prevalence of obesity in the United States, additional data are needed to confirm the clinical appropriateness of using carbapenem regimens that result in lower total daily doses.
Finding Volumes with the Definite Integral: A Group Project

(1995). Finding Volumes with the Definite Integral: A Group Project. The College Mathematics Journal: Vol. 26, No. 3, pp. 227-228.
Spring-tillage has no effect on the emergence pattern of glyphosate-resistant giant ragweed (Ambrosia trifida L.) in Nebraska

The objective of this study was to investigate the effect of spring tillage on glyphosate-resistant giant ragweed emergence pattern. Giant ragweed emerged from late Mar. until early June and tillag...
Powerful Husbands and Virtuous Wives: The Familial Structure in the Leadership of the New Life Movement, 1934-1938

Author(s): Sun, Xiaoping | Abstract: In February 1934 the Chinese Nationalist Party launched the New Life Movement with the goal of making strong and modern national citizens through social and cultural reforms with the emphases on cleanliness and discipline. It was initiated by the Generalissimo, led by officials, and first practiced in the state apparatus—central and local government agencies, schools, and military forces. I call it a male strategy of mobilizing the Chinese nation for a modern state. The presumption of the male political and social subject as the norm resulted in the tactic of turning state agents, overwhelmingly male, into social leaders. But this male strategy turned out to be unsuccessful when male state agents tried to “propagate, implement, guide and inspect” inside the home, even though they themselves were all family members and resided in households. So male New Life leaders transferred the task of modernizing the home to women and made their wives responsible for mobilizing ordinary women to fulfill the task.This paper focuses on the first stage of women’s mobilization in the New Life Movement from 1934 to 1938 by showing how this approach to women’s organizing emerged. By examining the structure of New Life leadership and the power relations between women’s New Life organizations and male New Life committees, I argue that gendered leadership did successfully mobilized women of the family for, and into, the nation-state-society whole, but also paradoxically reinforced the gendered labor division in between the domesticity and the nation-state-society whole.
Minimal change disease: A case report of an unusual relationship

Kidney injury associated with lymphoproliferative disorders is rare, and the exact pathogenetic mechanisms behind it are still poorly understood. Glomerular involvement presenting as a nephrotic syndrome has been reported, usually secondary to membranoproliferative glomerulonephritis. We report a case of a 63-year-old male who presented with bilateral leg swelling due to nephrotic syndrome and acute kidney injury. A kidney biopsy showed minimal change disease with light chain deposition; however, no circulating light chains were present. This prompted a bone marrow biopsy, which showed chronic lymphocytic leukemia (CLL) with deposition of the same kappa monoclonal light chains. Three cycles of rituximab and methylprednisolone resulted in remission of both CLL and nephrotic syndrome, without recurrence during a three-year follow-up.
Long-acting interferon for myeloproliferative neoplasms - an update.

Myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem cells, in which one or more of the myeloid lineages are involved. Targeted tyrosine kinase inhibitors have revolutioniz...
Acute shoulder dislocation. Indications and techniques for operative management.

This article reviews the natural history of the initial traumatic anterior shoulder dislocation. The literature is compared with the experience at the US Military Academy in a uniform group of young athletes. The concept and rationale for acute arthroscopic stabilization are introduced. Operative indications and the current arthroscopic technique are detailed.
Abstract B061: CD81: A new target for therapy of B cell lymphoma

CD81 belongs to an evolutionary conserved family of proteins named tetraspanins and it was originally described as a B cell target. Tetraspanins associate in multi-molecular complexes in tetraspanin-enriched microdomains (TEMS). Indeed, in B cells CD81 associates with CD19 and CD21, and together function as co-receptor to lower the cell activation threshold initiated by the BCR. Recently, we have demonstrated the importance of CD81 in tumor growth and metastasis of solid tumors1. However, the role of CD81 in B cell malignancies has not been explored. Previously, we have shown that anti-CD81 antibodies had anti-proliferative effects on human B cell lymphoma cell lines in vitro2. Here we tested the therapeutic effect of a mouse anti-human CD81 antibody in vivo against Raji and SUP-B8 B cell lymphomas using a xenograft model in SCID mice. Our studies demonstrated that our anti-CD81 antibody had therapeutic effect comparable to rituximab. Moreover, we found ADCC as one of the mechanism of action. Furthermore, to enhance the anti-CD81-mediated ADCC we engineered chimeric antibodies containing human IgG1ADCC-HIGH and human IgG4 ADCC-LOW Fc constant regions. Indeed, the chimeric human IgG1 anti-CD81 mAb showed a remarkable increase in NK cell-mediated ADCC compared to Rituximab in vitro. These results suggest that CD81 can be a potential therapeutic target on B cell lymphomas by virtue of both its direct cytotoxic effect and as a mediator of ADCC. The Human IgG1 version is being developed as a therapeutic candidate. 1. Vences-Catalan, F., et al. Cancer Res 75, 4517-4526 (2015). 2. Oren, R., Takahashi, S., Doss, C., Levy, R. & Levy, S. Mol Cell Biol 10, 4007-4015 (1990). Citation Format: Felipe Vences-Catalan, Chiung-Chi Kuo, Ranjani Rajapaksa, Ronald Levy, Shoshana Levy. CD81: A new target for therapy of B cell lymphoma [abstract]. In: Proceedings of the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; 2016 Sept 25-28; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(11 Suppl):Abstract nr B061.
Prioritizing protected areas in Madagascar for lemur diversity using a multidimensional perspective

Abstract Biodiversity is affected by anthropogenic activities, with a trend of decreasing species richness with habitat degradation. Decreasing species richness erodes evolutionary history and ecosystem function, but taxonomic, phylogenetic and functional diversity can have contrasting patterns. It is essential to measure these dimensions of biodiversity explicitly and assess how they are valued in prioritizing protected areas (PAs) to conserve diversity. Madagascar is a biodiversity hotspot, with high diversity and endemism coupled with heavy anthropogenic pressure. The endemic primates – lemurs – are the most endangered mammal taxon. A recent action plan prioritized PAs based on lemur species richness, weighted by endangerment. This scheme does not capture the evolutionary, functional, or biogeographic components of biodiversity, nor does it directly assess the level of human threat to those PAs. I compiled the largest dataset on lemur community composition in 100 PAs, including almost all lemur species (98 species). I combined data on lemur occurrence, their phylogeny, functional traits, IUCN Red List status, and environmental variables including deforestation between the years 2000 and 2014. I ranked PAs based on 14 metrics as well as the sum of metrics to determine how PA priorities compare under different valuation schemes. Based on the sum of seven metrics, I identified the top 25 PAs for lemur conservation. With these priority rankings, I propose areas of high lemur diversity, habitat heterogeneity and productivity, and deforestation be the focus of future conservation activities to maximize community resilience and prevent the erosion of evolutionary diversity and ecosystem function.
Treatment of PIK3CA and APC mutant colorectal cancers with dual PI3K/mTOR inhibition.

e14632 Background: Colorectal cancer (CRC) remains a leading cause of mortality and morbidity, despite developments in the understanding of tumor biology. The diverse nature of these cancers calls ...
The endless pursuit for self-validation through attainment: An examination of self-esteem in relation to workaholism

Abstract Relationships among self-esteem, workaholism, and work stress were investigated. Data were collected from 414 faculty and staff members at a large Southeastern university and a large manufacturing organization. Workaholism and work stress were positively related to each other, while self-esteem was negatively related to workaholism. A serial mediation analysis revealed that all direct paths were statistically significant, with the exception of the direct path from self-esteem to work stress. Low self-esteem led to workaholism, workaholism led to working more hours and to greater work stress, and working more hours also led to increased stress.
Alcohol and Drug Use, Pain and Psychiatric Symptoms among Adults Seeking Outpatient Psychiatric Treatment: Latent Class Patterns and Relationship to Health Status

ABSTRACTBackground: Substance use, psychiatric problems, and pain frequently co-occur, yet clinical profiles of treatment-seeking patients are poorly understood. To inform service and treatment planning, substance use and symptom patterns were examined in an outpatient psychiatry clinic, along with the relationship of these patterns to demographic characteristics and physical health. Methods: Patients (N = 405; age M = 38; 69% White; 60% female) presenting for intake in a psychiatry outpatient clinic completed a computerized assessment of psychiatric problems, drinking, and drug use. Substance use and psychiatric symptom patterns among the sample were identified using latent class analysis. Results: A 4-class model fit the data best: Class (1) Moderate symptoms/wide-range users (22.0%) had moderate depression and panic; tobacco, cocaine, hallucinogen, and ecstasy use; and high cannabis use. Class (2) Moderate depression/panic (37.8%) had moderate depression and panic. Class (3) Depression/anxiety, tobacco...
Non-human papillomavirus virus-related cervical neoplasms

Abstract Cervical cancer is a heterogeneous disease composed of mainly squamous and glandular lesions. The majority of the squamous lesions as well as glandular (endocervical) carcinomas are HPV-associated. Small but growing subgroups of adenocarcinoma are non-HPV related; this includes adenocarcinoma subtypes with uncertain association and a new subtype of adenocarcinoma recently introduced in the 2014 World Health Organization Classification of Tumours of Female Reproductive Organs named gastric type adenocarcinoma, included as part of the mucinous carcinomas. In this review we will describe each of the subtypes of endocervical adenocarcinomas, its association or not with HPV and a more detailed description of those non-HPV related.
Vital Bonds: Social Support, Social Networks, and Health

For some people it is so enmeshed in their daily lives that they take it for granted, others experience it when people rally around them in a crisis, and still others may never experience it at all. This tangible and intangible aspect of human behavior is called social support. The term “social support” is generally not used in everyday conversation, rather it is referred to as “she is always there when I need her,” or “she is the only person I can trust and confide in,” or “I get lots of help from my neighbors,” or “he is someone I can always count on.” Socially supportive behavior indicates that people have a reciprocal helping relationship, that they genuinely care about one another, and that the needs of others equal or surpass one’s own needs.
Bounds on Effective Properties

Here we survey the results of the bounding of elastic moduli of a two-dimensional two-phase composite. These bounds are physically interesting because they show the limits of improvement in the properties of a composite due to variation of its structure. They are important for the optimal design of materials and structures. The examples herein demonstrate the use and development of the translation method and the laminate technique.
Development of a Computer-Aided Analysis Method for Sheet Material Forming Processes

The computer-aided engineering method can be incorporated in a number of material processing operations to reduce engineering, manufacturing and material costs. With this objective in mind, an interactive computer software package has recently been developed to predict the degree of success or failure of formed sheet metal parts at the design stage to minimize the traditional trial and error process. For example, given the material properties, the rate of deformation, the geometry, and loading boundary conditions, the program computes the distribution of major and minor strains in the part to be formed. Concurrently, the limiting strain forming limit diagrams corresponding to the particular material are computed based on the defect growth model. The computed strain distribution is then directly compared with the forming limit diagrams so that any design and processing changes can be made at the computer terminal. Several examples of computed results are presented which, in turn, are directly compared with the measured strain distributions obtained from the circular grid technique. Included in the experimental work are aluminum-killed steel, enameling iron, and high strength steel sheets.
On Doing Critical Policy Analysis

In my comments on this fine collection of critical policy analyses, I want to do a number of things. I shall point to the general conceptual and social orientation and commitments that provide the ...
Individual differences in absolute pitch performance: Contributions of working memory, musical expertise, and tonal language background.

Abstract By definition, individuals with absolute pitch (AP) can categorize with near perfect accuracy without a reference pitch. This definition implies a uniformity of performance across people; however, in reality AP is a complex, multidimensional ability, shaped by both early and recent auditory experiences. In the present study we assess whether AP possessors' accuracy for identifying isolated notes is more distributed when judging more challenging instrumental timbres and octaves, as well as whether variability in note categorization could be explained through individual differences in musical expertise, language background, or working memory. In a standard test of AP, all participants performed virtually perfectly. When tested on the challenging notes, performance was more normally distributed. In exploratory analyses, we found (1) lower accuracy among participants who speak a tonal language, (2) less musical expertise among tonal language participants, and (3) a positive relationship between working memory and note performance among tonal language participants that was not present for non-tonal language participants. Taken together, these results highlight the complexity of AP categorization when considered as an auditory skill rather than a native talent. The observation that working memory may be an important in AP categorization under some challenging circumstances is consistent with recent theoretical accounts of how working memory and expertise relate to auditory recognition more broadly.
Orthopedic versus Neurosurgery-Understanding 90-Day Complications and Costs in Patients Undergoing Elective 1-Level to 2-Level Posterior Lumbar Fusions by Different Specialties.

Background Lumbar fusions are routinely performed by either orthopedic or neurologic spine surgeons. Controversy still exists as to whether a provider's specialty (orthopedic vs. neurosurgery) influences outcomes. Methods The 2007–2015Q2 Humana Commercial Database was queried using Current Procedural Terminology codes (22612, 22614, 22630, 22632, 22633 and 22634) to identify patients undergoing elective 1-to-2 level posterior lumbar fusions (PLFs) with active enrollment up to 90 days after procedure. Ninety-day complication rates were calculated for the 2 specialties. The surgical and 90-day resource utilization costs for the 2 groups were compared, by studying average reimbursements for acute-care and post–acute-care categories. Ninety-day complications and costs were compared using multivariable logistic and linear regression analyses. Results A total of 10,509 patients (5523 orthopedic and 4986 neurosurgery) underwent an elective 1-to-2 level PLF during the period. With the exception of a significantly lower odds of wound complications (odds ratio, 0.81) and a higher odds of dural tears (odds ratio, 1.29) in elective PLFs performed by orthopedic surgeons, no statistically strong differences were seen in 90-day complication rates between the 2 groups. Total 90-day costs were also similar between orthopedic surgeons and neurosurgeons, with the only exception being that surgeon reimbursement was lower for orthopedic surgery versus neurosurgery ($1202 vs. $1372; P Conclusions It seems that a provider's specialty does not largely influence 90-day surgical outcomes and costs after elective PLFs. The results of the study promote the formation and acceptance of dual training pathways for entry into spine surgery.
Structural states of the binuclear copper cluster of Cancer magister methemocyanin.

Abstract The binuclear cupric copper cluster of Cancer magister methemocyanin prepared from hemocyanin and hydrogen peroxide is diamagnetic (1). Upon treatment with azide, it is transformed into magnetic dipolar coupled (paramagnetic) Cu(II) pairs and then into magnetically isolated Cu(II) complexes. This progressive uncoupling of the binuclear cupric pairs in methemocyanin is interpreted in terms of a relaxation of superexchange through one or more bridging ligands.
The Structure of Superspace

Publisher Summary In classical geometrodynamics, one is led to a configuration space, S(M), which is a stratified Frechet manifold. In quantum geometrodynamics, one must allow the underlying topology to fluctuate. In fact, the fluctuations of the topology and metric will be so violent that the resulting spaces will seem foam like. This chapter discusses the superspace S of isometry classes of compact metric spaces and discusses that one can define a natural metric D on S. It also describes some of the properties of the metric space (S,D). A usual assumption of classical cosmology is that space is a Riemannian 3-sphere whose metric is close to the standard metric. If one assumes that in quantum cosmology the probability measure is concentrated near S3 in the metric D, then one has the prediction that, with very high probability, space will be a foamy 3-sphere.
Fatigue retardation due to creep in a fibrous composite

Experiments performed to determine the effects of temperature and creep strain on the fatigue life of a graphite/epoxy composite laminate show that (1) sustained periods of static loading have significant retardation effects on the fatigue degradation rate of the laminated composite, and (2) cyclic loading with a lower frequency preceding higher frequency loading also prolongs the fatigue life. A creep crack hypothesis is proposed that can provide reasonable interpretations for these experimental results.
A narrative review examining intersections of identity in older adult suicidality

Abstract The burgeoning older adult population requires a shift in focus in health prevention efforts to encompass those in later life. Within the broader older adult community, diverse older adults comprise an increasingly larger segment of the older adult population. One area of ongoing concern for the health and well-being of older adults is suicide. Risk and protective factors for older adults have been well documented. However, thorough examination of risk or protective factors for suicide within elders who experience ethic, linguistic, or cultural gerodiversity and elders whose intersections of identity includes multiple stigmatized identities, remains underexplored. Consequently, the aims of this narrative review are to: (1) provide prevalence rates for death by suicide in US older adults across different identity statuses, (2) describe identity status differences in risk and protective factors for late life suicide, and (3) provide examples of culturally responsive suicide prevention and intervention. Literature reviewed suggests that the current understanding of late life suicide is most representative of suicide-related outcomes in White, non-Hispanic elders. To represent the growing heterogeneity of the older adult population in the United States, there is a need to incorporate the unique risk and protective factors of diverse intersecting identities and to expand our conceptualization of suicide in late life to encompass the role of oppressive environments and systemic inequalities.
Anti-inflammatory activity of ayahuasca: therapeutical implications in neurological and psychiatric diseases.

Abstract Ayahuasca is a decoction with psychoactive properties, used for millennia for therapeutic and religious purposes by indigenous groups and the population of amazonian countries. As described in this narrative review, it is essentially constituted by β-carbolines and tryptamines, and it has therapeutic effects on behavioral disorders due to the inhibition of the monoamine oxidase enzyme and the activation of 5-hydroxytryptamine receptors, demonstrated through preclinical and clinical studies. It was recently observed that the pharmacological response presented by ayahuasca is linked to its anti-inflammatory action, attributed mainly to dimethyltryptamines (N, N-dimethyltryptamine and 5-methoxy-N, N-dimethyltryptamine), which act as endogenous systemic regulators of inflammation and immune homeostasis, also through sigma-1 receptors. Therefore, since neuroinflammation is among the main pathophysiological mechanisms related to the development of neurological and psychiatric diseases, we suggest, based on the available evidence, that ayahuasca is a promising and very safe therapeutic strategy since extremely high doses are required to reach toxicity. However, even so, additional studies are needed to confirm such evidence, as well as the complete elucidation of the mechanisms involved.
The Sine Qua Non of Carl Schmitt’s political thinking: The issue of interstate relations:

This article demonstrates the pre-eminent place the issue of interstate relations occupies in Carl Schmitt’s political thinking between the early 1920s and early 1940s. First, I discuss how Schmitt...
Efficient coherent population transfer between the a Σ 3 and the X Σ 1 states of K 39 Rb 85

We present calculations for a coherent population transfer [stimulated Raman adiabatic passage (STIRAP)] between the two lowest electronic ground states of the KRb molecule. In contrast to previous work on STIRAP in molecular systems, position dependent transition dipole moments are included in the calculation to take the mixed singlet-triplet nature of the intermediate state into account. Additionally, we incorporate the kinetic energy term and position dependent electronic states of the molecule. Transfer efficiencies of up to 58% can be achieved for moderate laser pulses in the picosecond range. Calculations with constant transition dipole moments show a much higher transfer of 94% and thus overestimate the efficiency significantly.
Blood Substitutes and Artificial Oxygen Carriers

Allogenic blood transfusion and human blood donation is a vital and necessary component of medicine and resuscitative efforts. However, it is not without risk and is subject to supply and availability. Blood transfusion performs many functions, such as volume expansion, but we have developed substitutes for a number of these functions. Unfortunately, the most important task of red blood cells is the carrying and delivery of oxygen to tissues and for this we do not have an adequate substitute. An artificial oxygen carrier that could be derived in the lab and made at will would solve many of the complications associated with transfusion medicine. Risk of infection from HIV and hepatitis C would be non-existent. Supply shortages and storage issues potentially would be a thing of the past. Transfusion reactions from ABO incompatibility would no longer pose a danger to our patients. A number of possibilities have been investigated in the past with mixed results, but there is hope and research efforts are ongoing. Despite this, currently there is no blood substitute clinically available in the U.S approved for regular use. However, some are available in other countries and attainable under certain conditions.
The Results of Exit Polls in Kansas to Verify Voting Machine Counts in the November 2016 Election

Citizens’ exit polls are performed by local voters to verify the official reported election results. Five citizens’ exit polls were run in southeast Kansas during the Nov 8th 2016 election. These exit polls were designed specifically to verify computer generated vote counts and run solely by volunteer labor, all local citizens who were willing to put in the necessary hours on Election Day to conduct the poll and later, to count the results by hand. These exit polls were able to obtain high participation rates resulting in the ability to detect small yet statistically significant differences. All five polling stations surveyed show evidence of multiple statistical anomalies in both the pattern and size of the errors between the official results and exit poll results although biases were not uniformly oriented across sites. The small discrepancies found in the studied races were insufficient to alter the outcomes. Non-response bias and unintentional errors were evaluated as potential causes; those explanations were plausible in some but not all cases. These results show a pattern of discrepancies between the exit polls and computer counted results displaying consistent bias within sites. This would be an expected outcome of a deliberate manipulation of the computer results. While this data doesn’t conclusively prove election interference and manipulation of votes counts, it should be taken seriously as a sign of such interference. Doubts about the accuracy of the reported results are appropriate unless other plausible explanations for the discrepancies can be found.
The Impact of Pathophysiology as a Nursing Prerequisite on the Retention and Grades of Junior BSN Nursing Students

Professional nursing requires a substantial knowledge base of Human Pathophysiology when making decisions in patient care, so a foundational knowledge of Human Pathophysiology (HP) is critical to the success of nursing students. Students entering a nursing program must have a solid foundational knowledge to ensure success throughout the curriculum. The majority of students who are unsuccessful in nursing programs face difficulties in the first year of the curriculum. HP has been identified as a foundational nursing course and may impact the academic success of students. Through a retrospective comparative analysis, the exam averages and attrition rates were analyzed with a convenience sample of 227 junior BSN students. The sequencing of HP was compared over four cohorts; two cohorts that complete HP during the second semester of the junior year in the nursing curriculum, and two cohorts who completed HP as a nursing curriculum prerequisite. The curricular resequencing was found to have a statistically significant impact on the exam averages in two of the five junior level nursing courses examined, specifically the exam average in Mental Health improved by nearly 5 percentage points and Health Assessment improved by 3 percentage points. Retention rates also increased by 20% as a result of this change in curriculum sequence. By providing a solid foundational knowledge on HP prior to embarking on the nursing curriculum, the likelihood of successfully completing the curriculum and passing the NCLEX-RN is improved.
Efficacy of estimating VO2max with the Heart Rate Ratio Method in middle-aged and older adults.

Investigate difference, agreement, and bias between maximal oxygen consumption (VO2max) measured by indirect calorimetry and the Heart Rate Ratio Method (HRRM) for estimating VO2max using measured and age-predicted maximum heart rate (HRmax) in a sample of middle-aged and older adults. Eleven men and nine women (age: 61.8 ± 8.5 years, VO2max: 36.6 ± 9.5 mL/kg/min, N = 20) had their VO2max measured via a maximal graded exercise test and confirmed using a verification bout on a treadmill ergometer. Participants’ VO2max was estimated via the HRRM using measured and age-predicted HRmax. Difference, agreement, and bias between methods were assessed using a one-way repeated measures Analysis of Variance (ANOVA), Lin’s concordance correlation coefficient, and Bland–Altman plots, respectively. There were no statistical differences between methods of assessing VO2max, F(1.13, 21.47) = 0.583, p = 0.473, generalized eta-squared = 0.012. The standard error of the estimate (SEE) for the HRRM using measured or predicted HRmax was 5.2% and 5.6% of the mean VO2max, respectively. Both HRRM predictions had poor agreement with VO2max (rc ≤ 0.40). There was a systematic bias to underestimate as VO2max increased for HRRM using measured HRmax, F(1, 18) = 17.40, p < 0.001, and when using an age-predicted HRmax, F(1, 18) = 13.39, p = 0.002. Both versions of the HRRM have poor agreement, relatively large SEEs, and a bias to misrepresent VO2max. When possible, VO2max should be measured via a maximal graded exercise test with indirect calorimetry for middle-aged and older adults.
Examining Social Setting and Product Reference via Conjoint Analysis An Empirical Study of Restaurant Patronage

This paper employs the conjoint measurement methodology to examine the impact of social setting on preferences for restaurants. It is shown that those who go to restaurants with friends differ from those who go with family in terms of importance attached to different restaurant attributes and demographic characteristics. Some managerial implications of the study are discussed.