Cartilage and Labrum Mechanics in Normal and Pathomorphologic Hips

Introduction: Most cases of hip osteoarthritis (OA) are believed to be caused by alterations in joint contact mechanics resulting from pathomorphologies such as acetabular dysplasia and acetabular retroversion. Over the past 13 years, our research group has focused on developing approaches for patient-specific modeling of cartilage and labrum in the human hip, and applying these approaches to study hip pathomorphology. The long term objective is to improve the understanding of the etiology of OA related to hip pathomorphology, and to improve diagnosis and treatment. The objectives of this presentation are to provide a summary of our subject-specific modeling approach, and to describe the results of our analysis of hips from three populations of subjects: normal, traditional dysplastic, and retroverted. Methods: A combined experimental and computational protocol was used to investigate contact mechanics in ten normal subjects (normal center edge angles (CEA), no history of hip pain), ten subjects with hip pain secondary to acetabular dysplasia (CEA less than 25°), and ten patients with a radiographic crossover sign, pain and clinical exams consistent with acetabular retroversion. CT arthrography was used to image cartilage and bone. Volumetric image data were segmented and discretized, and subject-specific finite element models were produced using validated methods [Fig. 1]. Boundary and loading conditions were obtained from instrumented implant and gait data. Contact mechanics were evaluated on the acetabular cartilage and labrum. Labrum contact area and peak contact stress were evaluated. Cartilage contact area, peak and average contact stress were evaluated in six anatomical regions in the acetabulum. Results: Hip contact patterns were subject-specific, but distinct patterns emerged in the groups. Dysplastic hips had a larger contact area in the lateral region of the acetabulum, while normal hips demonstrated a more distributed contact pattern. The labrum in dysplastic hips supported significantly more load than the labrum in normal hips in all activities [Fig. 2]. Contact in retroverted hips tended to be focused medially and superiorly [Fig. 3]. Retroverted subjects had smaller contact stress and area in most regions. Discussion: The differences in labrum mechanics between the normal and dysplastic groups provide clear support for the mechanical importance of the acetabular labrum in dysplastic hips. There were only minor differences in cartilage contact stress and area between normal and dysplastic groups, because of a lateral shift in the location of contact and subsequent loading on the acetabular labra in the dysplastic hips. The larger labrum load support and contact area in dysplastic hips indicates that the labrum compensates for the shallow acetabula. Clinically, this may account for the pattern of OA onset in dysplastic hips. The results for the retroverted group do not support the commonly held belief that concentrated posterior loading in retroverted hips leads OA because there were lower contact stresses and areas in the posterior regions of retroverted hips. Further, these results suggest that rim trimming may be appropriate for retroverted hips. The preferred surgery likely depends on subtle patient specific aspects of hip pathoanotomy in both retroverted and dysplastic hips.