cssi/SciSciGPT-SciSciNet huggingface dataset:
Outpatient cardiac telemetry detects a high rate of atrial fibrillation in cryptogenic stroke

Abstract Background The etiology of cerebral ischemia is undetermined in one-third of patients upon discharge. Occult paroxysmal atrial fibrillation (PAF) is considered a potential etiology. A high rate of PAF detection with 21-day mobile cardiac outpatient telemetry (MCOT) has been reported in two small studies. Optimal monitoring duration and factors predicting PAF have not been adequately defined. Methods We performed a retrospective analysis on patients evaluated by MCOT monitoring within 6 months of a cryptogenic stroke or TIA. Multivariate analysis with survival regression methods was performed using baseline characteristics to determine predictive risk factors for detection of PAF. Kaplan–Meier estimates were computed for 21-day PAF rates. Results We analyzed 156 records; PAF occurred in 27 of 156 (17.3%) patients during MCOT monitoring of up to 30 days. The rate of PAF detection significantly increased from 3.9% in the initial 48 h, to 9.2% at 7 days, 15.1% at 14 days, and 19.5% by 21 days (p Conclusion MCOT frequently detects PAF in patients with cryptogenic stroke and TIA. Length of monitoring is strongly associated with detection of PAF, with an optimal monitoring period of at least 21 days. Of the predictors of PAF detection, the presence of premature atrial complexes on ECG held the strongest correlation with PAF.
Evaluation and management of pediatric rhegmatogenous retinal detachment

Pediatric rhegmatogenous retinal detachments are rare, accounting for less than ten percent of all rhegmatogenous retinal detachments. While most retinal detachments in the adult population are related to posterior vitreous detachment, pediatric retinal detachment are often related to trauma or an underlying congenital abnormalities or genetic syndrome. The anatomy of pediatric eyes, the often late presentation of the disease, and the high incidence of bilateral pathology in children all pose significant challenges in the management of these patients. We discuss the epidemiology of pediatric rhegmatogenous retinal detachment, review the genetic syndromes associated with a high incidence of retinal detachment, and examine other common causes of retinal detachment in this age group. We then outline an approach to evaluation and management and describe the expected outcomes of repair of retinal detachment in the pediatric population.
Model-based demand-limiting control of building thermal mass

This paper describes the development and evaluation of a model-based approach for minimizing peak cooling demand using energy storage inherent in building structures. On any day where the strategy is invoked, the building is precooled with zone temperature setpoints at the low end of comfort prior to a demand-limiting (DL) period. The zone temperatures are then adjusted upwards during the demand-limiting period following a trajectory that keeps the peak cooling load below a specified target. The cooling demand target and setpoint trajectory are determined using a building model that is trained using field data. The overall approach was demonstrated for a building representative of a small commercial facility. The first step involved training the inverse model using a few weeks of hourly data. The model was then used to study the potential for peak load reduction and to determine setpoint trajectories that were implemented at the site. The demand-limiting strategy resulted in approximately 30% reductions in peak cooling loads compared to night setup control for a 5-h on-peak period of 1 PM to 6 PM.
PERCEIVED LEVELS OF CULTURAL COMPETENCE THROUGH SOCIAL WORK EDUCATION AND PROFESSIONAL DEVELOPMENT FOR URBAN SCHOOL SOCIAL WORKERS

The purpose of this article is to report on findings from an exploratory study that examines the linkages among social work education programs, professional development, and school social workers' perceived level of cultural competence in urban public school systems that have a majority African American student enrollment. This study seeks to shed light on the need to engage in empirical investigations concerning cultural competence and school social work practice. Findings from this study highlight the need for both social work education programs and postgraduate professional development programs to monitor practitioners' preparation for culturally competent practice in urban public school systems.
Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans

The purpose of this study was to determine if a relationship exists among skeletal muscle fiber composition, adiposity, and in vitro muscle glucose transport rate in humans. Rectus abdominus muscle...
A project of doubtful utility: measuring legislative opposition to the Pennsylvania Canal

Abstract A spatial model of legislative roll call votes is used to examine the debate surrounding the decision to build a canal across Pennsylvania in 1826. The model reveals a sharp polarization between the English and German-speaking regions of the state, with marked splits over the establishment and funding of the Pennsylvania Canal and other fiscal issues. Representatives from the German-speaking regions consistently opposed all spending initiatives. This regional split, underappreciated by geographers and historians, provides evidence in support of a broader positioning of culture and ethnicity in the study of political behavior. The model itself provides a novel means of analyzing and assessing geographically based voting blocs.
Effect of phenolphthalein on in vitro rabbit ileal electrolyte transport.

Abstract The effect of phenolphthalein on rabbit ileal electrolyte transport was studied to gain insight into the mechanism of cathartic action of this drug. Two separate effects were noted in Ringer solution in the Ussing chamber in vitro. First, when present in either or both the mucosal and serosal solutions, phenolphthalein caused a dose-related inhibition of the potential difference and the short-circuit current. Second, when present only on the mucosal side of the epithelium, phenolphthalein inhibited sodium chloride absorption (or caused sodium chloride secretion); when present only on the serosal side, phenolphthalein stimulated sodium chloride absorption. There was no clear difference between the effects of white and yellow phenolphthalein. In sodium-free solutions, mucosal phenolphthalein inhibited an apparent chloride:bicarbonate exchange, in chloridefree, bicarbonate-free, and chloride-bicarbonate-free solutions, mucosal phenolphthalein inhibited sodium absorption, while serosal phenolphthalein stimulated sodium absorption, as it did in Ringer solution. However, the ion accompanying the change in sodium transport in these anion-substituted solutions was the residual flux (? bicarbonate or hydrogen ion). At 10 −4 M, mucosal phenolphthalein but not serosal phenolphthalein inhibited glucose- and alanine-stimulated short-circuit current. Phenolphthalein did not increase tissue levels of cyclic nucleotides. Luminal phenolphthalein initially caused secretion in vivo, but this was short lived, perhaps indicating a serosal absorptive effect of the drug as it was transported across the epithelium. The inhibitory effects of mucosal phenolphthalein can be explained by inhibition of sodium-potassium adenosine triphosphatase and by inhibition of anion exchange and possibly sodium-coupled (chloride, glucose, and alanine) transport processes. The mechanism of the absorptive action of serosal phenolphthalein remains to be elucidated. It is clear, however, that this drug affects intestinal electrolyte transport by mechanisms other than inhibition of the sodium pump or by stimulating secretion via cyclic nucleotides.
Gene Targeting Approaches to Neuroendocrinology: Oxytocin, Maternal Behavior, and Affiliation

Transgenic technology affords exciting new opportunities in the field of behavioral neuroendocrinology. We have extended our research into the behavioral function of oxytocin in maternal and social behavior using two transgenic approaches: (i) targeted deletion of the oxytocin gene in mice and (ii) augmented oxytocin receptor expression in the brain. Mice genetically deficient in oxytocin can mate, give birth, and display normal maternal behavior; however, milk ejection and certain aspects of social behavior are affected. Comparative studies of oxytocin receptors have led to the observation that species differences in social organization are associated with differences in receptor distribution. Specifically, monogamous prairie voles and nonmonogamous, asocial montane voles exhibit different patterns of OT receptor expression in the brain. Transgenic mice have been created with a reporter gene driven by the prairie vole oxytocin receptor gene promoter. Analysis of the expression pattern suggests that it should be possible to manipulate receptor expression in the vole brain in order to examine the effects of receptor distribution on behavior.
A New Approach to the Chemistry of Aromatic Ammonia Spirit

Abstract Standard reference texts state that the milky-white precipitate encountered in the preparation of Aromatic Ammonia Spirit, U.S. P., is unreacted ammonium bicarbonate due to an insufficient ammonia concentration. An examination of chemical equivalents shows that there is an excess of ammonia present. The precipitation is due to the volatile oils thrown out of solution by the lowering of the alcoholic concentration. A crystalline precipitate of normal ammonium carbonate can be produced by control of certain conditions.
Information hiding in product development: the design churn effect

Execution of a complex product development project is facilitated through its decomposition into an interrelated set of localized development tasks. When a local task is completed, its output is integrated through an iterative cycle of system-wide integration activities. Integration is often accompanied by inadvertent information hiding due to the asynchronous information exchanges. We show that information hiding leads to persistent recurrence of problems (termed the design churn effect) such that progress oscillates between being on schedule and falling behind. The oscillatory nature of the PD process confounds progress measurement and makes it difficult to judge whether the project is on schedule or slipping. We de- velop a dynamic model of work transformation to derive conditions under which churn is observed as an unin- tended consequence of information hiding due to local and system task decomposition. We illustrate these conditions with a case example from an automotive development project and discuss strategies to mitigate design churn.
Alterations of T Lymphocytes in Inflammatory Bowel Diseases

Data from multiple experimental models to date provide strong support for the immunologic hypothesis that a dysregulated mucosal CD4+ T cell response to antigens of the enteric bacteria in a genetically susceptible host results in chronic intestinal inflammation. The host interaction with the flora is complex, but there are a select number of cells and molecules that are critical to this effort. When these key pathways are impaired, the host response to the bacterial flora results in IBD. The key effector cell responsible for disease in most instances is the CD4+ T cell. Although there is data in some systems that Th1 and Th2 subsets can reciprocally regulate one another, each of these CD4 T cell effector CD4 T cell subsets has been found to mediate colitis in various mouse models. There is no data at present that demonstrates that Th2 cells regulate Th1 cells in the intestine or vice versa, and thus experimental colitis is not explained as an imbalance between Th1 and Th2 subsets. At present the data are compatible with the concept that excessive responses of either the Th1 or Th2 effector subsets are detrimental and can result in inflammatory bowel disease, and that this is prevented in the normal host by the presence and function of regulatory cells, particularly CD4+ Tregs. It is unclear how many distinct subsets of regulatory cells are present in the intestine, or the role that each may play in regulating the mucosal immune response to commensal bacterial antigens.
Carbon Dioxide Capture Using Sorbent-Loaded Hollow-Fiber Modules with Integrated Heat Recovery

A model of a rapid temperature swing adsorption CO2 capture module using sorbent-loaded hollow fibers is presented. The system incorporates an integrated heat recovery technique using a thermal wave to reduce the external thermal input and operational energy costs of the capture facility. The model includes a detailed heat and mass transport model for the sorbent-loaded fibers to address accurately the rapid radial kinetics of the adsorption process. The local heating and cooling of the sorbent possible with the use of coupling fluid in the bore of the fibers significantly reduces the time required for each adsorbing and desorbing phase. Results for a representative operating condition indicate that a capture facility based on the sorbent-loaded hollow fibers can achieve significantly higher sorbent productivities (∼1400%) than that of other thermally driven capture technologies with moderate energy consumption (∼5.9 MJ kg–1). The very fast cycle times (∼100 s) achievable with this adsorption process enab...
Lead, Follow or Be Left Behind: The Case for Comprehensive Ocean Policy and Planning for Florida

Although coastal zone management certainly incorporates the adjacent seas, during the first decades of the Coastal Zone Management Act of 1972 (CZMA) states directed most policy development and management efforts to the landward side of the coastal zone where the most immediate conflicts and needs arose. At the federal level, even extension of a 200-mile Exclusive Economic Zone (EEZ) in 1983 led to little or no change in ocean policy or ocean management. The seas were undoubtedly becoming more intensely used for both living and non-living resource development, but the United States dealt with these issues primarily through legal regimes addressing single sectors, such as offshore oil and gas development or fisheries management. Today ocean uses are intensifying, raising user conflicts and stressing ocean resources and ocean systems more than humanity was considered capable of doing a century ago. Tragedies like the BP oil spill demonstrate the widespread effects of a single ocean use across all sectors of ocean and coastal activities and on the ecosystems upon which these sectors rely. Management of today’s oceans requires rational development of ocean policies, priorities, and governance structures. On July 19th, 2010, President Obama established the first United States national ocean policy, creating federal framework for implementing ocean policy and planning. For states that have taken significant steps toward planning and management of ocean waters within their boundaries, coastal and marine spatial plans potentially provide new opportunities for assuring that development and activities in the federal offshore will adequately considers state policies and priorities. For other states, like Florida, that have not developed comprehensive coastal and marine policy and planning, national ocean policy development may mean weak participation in the regional planning process, loss of state prerogative concerning major coastal planning issues and a fundamental failure in the governance of the states in regard to their coasts and waters. This article looks at the historical development of state ocean policy development, including the motivations of coastal states to take steps to develop comprehensive state ocean policy. Next the article addresses why “now” is the critical time for state ocean policy development. Finally, the article addresses the guiding principles for Florida’s ocean policy development.
Preserving the Constitution: The Conservative Basis of Radical Reconstruction

IN the 1950s and especially the 1960s, Reconstruction history underwent its own reconstruction. As twentieth-century Americans became more and more aware of their own racial crisis, historians reassessed the racial crisis which faced their ancestors, bringing to the profession and to the public a new appreciation of the problems Americans faced in restoring national and state governments in which the personal and civil rights of black Americans would be protected for the first time.' Historians have reevaluated the motives of the so-called Radical Republicans, the character of President Andrew Johnson, and the very nature of the issues which confronted Americans after the Civil War. But they have not yet reevaluated the constitutional framework within which Reconstruction proceeded, despite the fact that, in Eric L. McKitrick's words, constitutional limitations formed "an indispensable part of the framework within which men thought in the nineteenth century."2 Most recent scholars have abandoned the prejudicial
Application of IC Anerobic Technique in the Treatment of Waste Water of Weilin Wine

The advantages of IC reaetion tank in the treatment of waste water were as follows: small floor space required, short start-up period, large treatment capacity, short dwell time of hydro power, economical investment, high treatment efficiency; the total re-moval rates of pollutants were: COD 91 % and suspended substance SS 99 %; the waterexit pH value 6.8; the effective temperature range for treatment 25~40℃ and the optimal temperature range for high efficient treatment 36~38 ℃ .(Tran. by YUE Yang)
Controlled culture of adult human skin: Characterization

Long term growth and differentiation of adult human skin cells has been achieved by more effective control of culture pH, gas phase, osmolarity and nutrient supply at optimized set point values than that possible with conventional batch feed culture. This control was achieved by means of an automatic perfusion, rocker culture apparatus. The following characteristics of these skin cultures particularly lend themselves to application as a source of skin graft material for use in humans requiring large area skin grafts: high culture success rate was achieved in that 12/12 specimens of adult skin exhibited growth to confluence within 4-6 weeks. Cultures demonstrated logarithmic growth for a minimum of 5 weeks, 25-50 fold enhancement in area by 4-6 weeks, 16-fold increase in glucose utilization at 9 weeks, nearly 4-fold increase in total DNA at 5 weeks, and a minimum 6-fold increase in nuclei counts at 5 weeks in culture. The multilayered outgrowth maintained a predominantly epithelial cell composition, but contained normal skin cell types other than keratinocytes, including melanocytes, and dermal fibroblasts, which may be required for long term survival of cultured skin transplanted back to humans. Other than the use of 10% fetal bovine serum in culture medium and denatured bovine collagen substratum, the system did not require heterologous components for plating or growth stimulation. Neither mouse feeder cells, nor the selective pressures of passage were required to obtain growth in surgically useful quantities.(ABSTRACT TRUNCATED AT 250 WORDS)
Imiquimod-induced subacute cutaneous lupus erythematosus-like changes

Imiquimod is a topical immunomodulator used to treat genital warts and cutaneous malignancies that exerts its effects via induction of proinflammatory cytokines through activation of toll-like receptor (TLR) 7. Although subacute cutaneous lupus erythematosus (SCLE) has been reported in association with multiple systemic medications, SCLE in patients treated with topical agents has not been widely reported. We report the case of a 50-year-old woman with local induction of lesions that clinically and histologically resembled SCLE following treatment with topical imiquimod.
Optimal Flood Mitigation over Flood Propagation Approximations

Globally, flooding is the most frequent among all natural disasters, commonly resulting in damage to infrastructure, economic catastrophe, and loss of life. Since the flow of water is influenced by the shape and height of topography, an effective mechanism for preventing and directing floods is to use structures that increase height, e.g., levees and sandbags. In this paper, we introduce the Optimal Flood Mitigation Problem (OFMP), which optimizes the positioning of barriers to protect critical assets with respect to a flood scenario. In its most accurate form, the OFMP is a challenging optimization problem that combines nonlinear partial differential equations with discrete barrier choices. The OFMP requires solutions that combine approaches from computational simulation and optimization. Herein, we derive linear approximations to the shallow water equations and embed them in the OFMP. Preliminary results demonstrate their effectiveness.
Throughput improvement in interference limited multipath environments using a smart antenna for IEEE 802.11b WLAN

The results of throughput performance improvement from a ferroelectric smart antenna used in conjunction with a WLAN network interface card is presented in this paper. A two-element beamforming network was designed and implemented using ferroelectric phase shifters. The null point in the radiation pattern of the two element antenna was scanned using control software so that undesired incoming interference signals could be rejected, resulting in improved SNR for the downlink. The resulting improvement in throughput afforded by this smart antenna was compared with that of a conventional switched diversity antenna for both indoor and outdoor channels under both line-of-sight and non-line-of-sight propagation environments. The smart antenna system shows better performance in terms of data throughput rate and range extension to the access point.
Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis.

Background: The treatment of irritable bowel syndrome (IBS) is a challenge because its cause remains unknown. Previous clinical trials to examine the efficacy of probiotic Bifidobacterium infantis ...
Injuries of the External Ear

Ear injuries occur in people of all ages but predominate in active people such as wrestlers, boxers, and bike riders. The types and extent of injury are a function of the force causing the injury. Shearing forces of moderate intensity cause hematoma formation, whereas greater force causes lacerations or even amputation. Sharp objects cause lacerations determined by the force, direction, and point of impact. The high ratio of surface area to mass makes the auricle vulnerable to extremes of temperature. People participating in high-risk activities should wear protective headgear. The goal of treatment is to restore the normal contours while preventing infection. Hematoma results in disfigurement by organization or chondritis. Evacuation and pressure dressings using sterile technique correct the condition. Second-degree burns are treated by regular cleansing and application of topical antimicrobials. Deeper burns require debridement, biologic dressings, or burying the cartilage subcutaneously for later reconstruction. Simple lacerations are closed under aseptic technique using either skin-to-skin sutures only or sutures of the skin combined with intercartilage sutures. Extensive and complex lacerations require meticulous care to match all fragments and prevent infection or loss of tissue. Bare cartilage must be covered with vascularized tissue. The treatment of total amputation is controversial. Some advocate reattachment as a composite graft using intravenous low molecular weight dextrans and heparin as adjuvants. Mladick dermabrades the amputated pinna, reattaches it with sutures, and then slips it into a pocket of elevated postauricular skin for 2 weeks. Others urge microvascular reanastomosis of the small nutrient vessels. Brent and Byrd separate the cartilage from its overlying skin and envelope it first with vascularized temporoparietal fascia and then a split-thickness skin graft. Chondritis is the most feared complication of injury or surgery of the pinna. It is an aggressive process, and prompt removal of pus and necrotic cartilage is required. Exteriorization and removal of all cartilage is effective but disfiguring. Removal of only affected cartilage and constant irrigation with antibiotic solutions is effective but requires prolonged hospitalization. Iontophoresis of antibiotics into the auricle may be effective and conserve tissue. Traumatic deformities are corrected with composite grafts from the opposite ear, costal cartilage, and local pedicled flaps.(ABSTRACT TRUNCATED AT 400 WORDS)
Gift card program incrementality and cannibalization: The effect on revenue and profit

Abstract Many retailers have not measured the magnitude of cannibalization or its impact on revenue and profit when existing customers use a gift card for purchases they would have made without it, particularly when the card was purchased through a 3rd party at a discount up to 15%. We conducted a survey among gift card redeemers of a national casual dining restaurant chain to determine how the gift card affected their purchase behavior. We used this information, combined with operating margin, to model the impact of three different gift card discount scenarios on firm revenue and profit. Although the revenue effect was positive under all scenarios, the same was not true for profit. The profit was much lower than anticipated, even in the best case scenario, and was negative in the worst case scenario.
Subcutaneous Fat Distribution in Adolescents

Sibling resemblance in fatness and subcutaneous fat distribution is addressed in a sample of healthy adolescents who belong to 122 nuclear families. Relative fatness and fat distribution were estimated using anthropometric measurements, bioelectric impedance, and ultrasound images. The patterns of fat distribution were defined by indexes constructed using combinations of subcutaneous fat measurements. Adjusted Z scores were used to analyze age- and sex-related changes on fatness and fat distribution. An analysis of variance was used to calculate the resemblance within and between families. The results show that there is significant family resemblance for the level of fatness. There is also significant resemblance between sibs of like sex for the fat distribution patterns. The results also show that subcutaneous fat thickness has a strong genetic component (60-65% of the variance) and that the patterns of fat distribution are apparent from early adolescence.
Design of the New Prognosis Wearable System-Prototype for Health Monitoring of People at Risk

The paper presents the design framework of the Prognosis wearable system, which aims at realizing continuous and ubiquitous health monitoring of people at risk along with providing embedded decision support to enhance disease management and/or prevention. The system’s functional scheme is built on top of a formal language for describing and fusing health symptoms that are extracted from the acquired measurements of a variety of wearable sensors, which may be distributed over a patient’s body. Moreover, by incorporating an automated intelligent and interactive dialogue system, additional health-status feedback can be obtained from the user in terms of described symptoms, captured using a voice recognition module, which can further enhance the autonomous decisional capabilities of the system. A simulation framework built in Java is also presented in detail and is based on a previously presented Stochastic Petri Net functional model of the system, which was used to model the event-based operation of Prognosis and to capture the concurrency issues that arise in such a system design. Finally, the illustrated paradigmatic application scenarios clearly highlight the benefits of using an interactive and intelligent health monitoring system for remote care of patients in critical medical conditions.
When Good Deeds Hurt: The Potential Costs of Interpersonal Helping and the Moderating Roles of Impression Management and Prosocial Values Motives:

Drawing on the conservation of resource theory, the current study builds and tests a moderated-mediation model that explores the potential costs of engaging in interpersonal helping—a common type of organizational citizenship behavior. Specifically, this research argues that interpersonal helping induces emotional exhaustion, which adversely affects task performance. The study also examines impression management and prosocial values motives as conditional moderators among these relationships. Using multisource field data across two time periods, results suggest that an impression management motive is likely to strengthen the proposed relationships, whereas a prosocial values motive is likely to weaken them. Theoretical and practical implications as well as future research avenues are also discussed.
Champ-contre-champ: Slon/Iskra new social documentary through the lens of Jean-Louis Comolli’s militant cinephilia

Champ-contre-champ examines the writings of Jean-Louis Comolli, theorist and historian of political cinema, in parallel with the practices of grass-roots film documentary producer Slon/Iskra. As tw...
A Historical and Topographical Guide to the Geography of Strabo

Strabo's Geography, completed in the early first century AD, is the primary source for the history of Greek geography. This Guide provides the first English analysis of and commentary on this long and difficult text, and serves as a companion to the author's The Geography of Strabo, the first English translation of the work in many years. It thoroughly analyzes each of the seventeen books and provides perhaps the most thorough bibliography as yet created for Strabo's work. Careful attention is paid to the historical and cultural data, the thousands of toponyms, and the many lost historical sources that are preserved only in the Geography. This volume guides readers through the challenges and complexities of the text, allowing an enhanced understanding of the numerous topics that Strabo covers, from the travels of Alexander and the history of the Mediterranean to science, religion, and cult.
Brownfield Redevelopment: Recycling the Urban Environment

Brownfields are properties that are or could contain contamination, usually (but not always) due to their use for industrial or commercial purposes. Because such sites are found across the country but most notably in urban areas, finding ways to remediate and reuse them is a key urban development and environmental sustainability issue. Federal, state, and local governments have adopted policies to facilitate their reuse while protecting residents, as is evident in the redevelopment of the Waterworks Park site in Tampa, Florida. While brownfield redevelopment efforts have achieved considerable success in recent decades, the field faces limitations and challenges, most notably the possibility of reduced federal regulatory and support structures.
Dose-response relationship during motor learning with bimanual-to-unimanual training

Introduction/Background Few options exist for training arm movements in patients with little active movement in their affected arm after a stroke. The purpose of this study was to test the efficacy of bimanual-to-unimanual training in reducing upper limb motor impairment and active movement in the affected arm, and to examine the effect of training dose on motor learning. Material and method Twenty subjects with chronic post-stroke hemiparesis underwent 6 weeks of usual care. They then received 12 one-hour sessions of bimanual-to-unimanual training using the Bimanual Arm Trainer (BAT, Mirrored Motion Works, Inc.). The training consisted of bimanual training of both arms followed by unimanual training of the affected arm alone. Some patients received the 12 sessions over 4 weeks, whereas others received it within 6 weeks. Extent of motor impairment on the Fugl-Meyer scale and active movement at upper limb joints was examined at baseline and pre- and post-training. The degree of improvement in the affected arm was computed both within and between training sessions as well as pre- and post-training. Repeated measures ANOVA was performed on the variables of interest. Results Bimanual-to-unimanual training led to a significant improvement in upper limb Fugl-Meyer scores and active movement compared with usual care (P Conclusion Bimanual-to-unimanual arm training can reduce motor impairment in patients with chronic post-stroke hemiparesis. Higher frequency of training leads to greater improvements despite the same total dose. The study provides a means for understanding dosing of treatment for motor learning post-stroke.
Bis(tetra­phenyl­arsonium) hexa­chlorido­zirconate(IV) aceto­nitrile tetra­solvate

The bis­(tetra­phenyl­arsonium) hexa­chlorido­zirconate(IV) salt, (AsPh4)2[ZrCl6] (Ph = C6H5), was prepared more than 25 years ago [Esmadi & Sutcliffe (1991). Indian J. Chem. 30 A, 99–101], but its crystal structure was never reported. By following a similar experimental procedure, the compound was synthesized and its crystal structure was investigated as a aceto­nitrile tetra­solvate, (As(C6H5)4)2[ZrCl6]·4CH3CN, by single-crystal X–ray diffraction. The [ZrCl6]2− anion adopts a slightly distorted octa­hedral coordination sphere, with Zr—Cl bond lengths of 2.4586 (6), 2.4723 (6), and 2.4818 (5) A, and Cl—Zr—Cl angles ranging from 89.602 (19) to 90.397 (19)°.
Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet

Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating premature aging disease. Mouse models have been instrumental for understanding HGPS mechanisms and for testing therapies, which to date have had only marginal benefits in mice and patients. Barriers to developing effective therapies include the unknown etiology of progeria mice early death, seemingly unrelated to the reported atherosclerosis contributing to HGPS patient mortality, and mice not recapitulating the severity of human disease. Here, we show that progeria mice die from starvation and cachexia. Switching progeria mice approaching death from regular diet to high-fat diet (HFD) rescues early lethality and ameliorates morbidity. Critically, feeding the mice only HFD delays aging and nearly doubles lifespan, which is the greatest lifespan extension recorded in progeria mice. The extended lifespan allows for progeria mice to develop degenerative aging pathologies of a severity that emulates the human disease. We propose that starvation and cachexia greatly influence progeria phenotypes and that nutritional/nutraceutical strategies might help modulate disease progression. Importantly, progeria mice on HFD provide a more clinically relevant animal model to study mechanisms of HGPS pathology and to test therapies.
Quick Lime Production

This paper presents the impact of Engineering as a promoter of culture of peace and prosperity by applying the "Cal Viva Production" project developed by the Engineering Faculty of the Universidad La Salle Mexico, in order to improve the quality of life in the community of the municipality of El Botho in Hidalgo, Mexico, through sustainable infrastructure and organizational processes of production.
USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth

Ewing sarcoma is the second most common pediatric bone and soft tissue tumor presenting with an aggressive behavior and prevalence to metastasize. The diagnostic translocation t(22;11)(q24;12) leads to expression of the chimeric oncoprotein EWS-FLI1 which is uniquely expressed in all tumor cells and maintains their survival. Constant EWS-FLI1 protein turnover is regulated by the ubiquitin proteasome system. Here, we now identified ubiquitin specific protease 19 (USP19) as a regulator of EWS-FLI1 stability using an siRNA based screening approach. Depletion of USP19 resulted in diminished EWS-FLI1 protein levels and, vice versa, upregulation of active USP19 stabilized the fusion protein. Importantly, stabilization appears to be specific for the fusion protein as it could not be observed neither for EWSR1 nor for FLI1 wild type proteins even though USP19 binds to the N-terminal EWS region to regulate deubiquitination of both EWS-FLI1 and EWSR1. Further, stable shUSP19 depletion resulted in decreased cell growth and diminished colony forming capacity in vitro, and significantly delayed tumor growth in vivo. Our findings not only provide novel insights into the importance of the N-terminal EWSR1 domain for regulation of fusion protein stability, but also indicate that inhibition of deubiquitinating enzyme(s) might constitute a novel therapeutic strategy in treatment of Ewing sarcoma.
Overview of Homologous Recombination and Repair Machines

The study of homologous recombination between plasmids, or between a plasmid and the chromosome, revealed that the RecFOR pathway is less of a poor cousin than first thought. When the exquisite sensitivity to DNA damage of the first recombination-deficient mutants was found, it became clear that homologous recombination might be the only way to repair certain DNA lesions. Generally, the stronger the defect in homologous recombination, the higher the sensitivity to DNA damage. In Escherichia coli, chromosomal lesions are repaired by homology-guided strand exchange between sister chromatids. The evidence in support of this notion comes in three forms. First, physical connections between parental and daughter strands, associated with lesion repair, can be detected. Second, repair of chromosomal lesions is not observed in recA mutants. Third, DNA damage stimulates homologous recombination although the structure of chromosomal lesions in this case is unspecified. Single-stranded DNA-binding protein (SSB) complexes single-stranded DNA (ssDNA), facilitating its subsequent use in replication and in degradation and repair pathways of DNA metabolism. Chromosomal dimerization in E. coli creates a chromosomal lesion, because it prevents segregation of the replicated chromosomes into daughter cells. The understanding of the formation of replication-dependent chromosomal lesions is still primitive. There is one in vivo study on the structure of stalled replication forks, a report documenting replication fork reversal in vivo, as well as a few reports of replication fork reversal in vitro, likely to be an artifact of DNA isolation.
Differential derived stimulus relations across probe-trial versus adduction testing are not a function of comparison-stimulus presentation

The present research assessed whether unreliable derivation of three-node equivalence relations in adduction testing is due to the absence of comparison-stimulus presentation. College students first learned arbitrary-matching-to-sample discriminations (AB, BC, CD, and DE) with Arabic numbers (A), nonsense syllables (B, C, D), and nonrepresentational forms (E) as stimuli. Participants then were exposed to either probe-trial testing or adduction testing. In probe-trial testing, each trial involved one of the four E stimuli (e.g., E1) as a sample and each of the four A stimuli (A1, A2, A3, A4) as comparisons. Successful performance involved participants selecting the corresponding A stimulus in the absence of differential consequences (e.g., A1 in the presence of E1). In adduction testing, each trial involved an arithmetic equation such that successful performance involved combining derived EA relations with simple math skills. Critically, unlike in typical adduction testing, participants were presented with four response options to select from (i.e., comparison stimuli). In probe-trial testing, each participant derived the EA relations, whereas no participant performed successfully in adduction testing. The present findings suggest that the unreliable derivation of three-node equivalence relations in adduction testing is not due to the typical absence of comparison stimuli. The present research challenges experimental psychologists to clarify the role of testing context in identifying the necessary and sufficient conditions that control emergent learning.
Kenneth Burke + The Posthuman

As the field of rhetoric widens, traditional disciplinary questions have been textured by challenges to the idea of a universal human rhetor. The figure of the human has held a central place in rhe...
Long‐term outcomes of anterior cruciate ligament reconstruction surgery: 2020 OREF clinical research award paper

ACL injuries place the knee at risk for post-traumatic osteoarthritis (PTOA) despite surgical anterior cruciate ligament (ACL) reconstruction. One parameter thought to affect PTOA risk is the initial graft tension. This randomized controlled trial (RCT) was designed to compare outcomes between two graft tensioning protocols that bracket the range commonly used. At 7 years postsurgery, we determined that most outcomes between the two tension groups were not significantly different, that they were inferior to an uninjured matched control group, and that PTOA was progressing in both groups relative to controls. The trial database was also leveraged to gain insight into mechanisms of PTOA following ACL injury. We determined that the inflammatory response at the time of injury undermines one of the joint's lubricating mechanisms. We learned that patients continue to protect their surgical knee 5 years postinjury compared to controls during a jump-pivot activity. We also established that presurgical knee function and mental health were correlated with symptomatic PTOA at 7 years, that there were specific anatomical factors associated with poor outcomes, and that there were no changes in outcomes due to tunnel widening in patients receiving hamstring tendon autografts. We also validated a magnetic resonance imaging technique to noninvasively assess graft strength. In conclusion, the RCT determined that initial graft tensioning does not have a major influence on 7-year outcomes. Therefore, surgeons can reconstruct the ACL using a graft tensioning protocol that is within the window of the two graft tensioning techniques evaluated in this RCT.
Design an Optimal Blending Recipe via Scenario-based Chance-constrained Optimization.

A scenario-based optimization approach is proposed to design gasoline blending recipes under uncertainty. The proposed scheme considers the nonlinear mixing law of octane, uses Monte Carlo sampling-based method to simulate parametric uncertainties, and employs a sequential algorithm with bound tightening to obtain a γ-global optimal solution. This framework offers three advantages: First, incorporating the nonlinear functions into the chance-constrained optimization will improve predictions on the key properties of the blend. Second, by accounting for uncertainty in the blending process, a solution with best expected quality under several possible conditions can be achieved. Third, the sequential algorithm with bound tightening determines the γ-global optimal solution faster than directly using state-of-the-art optimization software. A case study with nine feedstocks and two products is presented to demonstrate the effectiveness of the proposed method.
China's Shoe Manufacturing and the Wenzhou Model: Perspectives on the World's Leading Producer and Exporter of Footwear

A U.S.-based geographer and specialist on China advances his research on industrial districts and regional development by presenting a 2008 study of shoe manufacturing in Wenzhou (a major center in the world's largest footwear producing and exporting country). More specifically, the author examines how the model of economic development pioneered in Wenzhou (the Wenzhou model) has been transformed in an effort to meet the challenges posed by the global economy. He argues that the scaling up of Wenzhou's footwear industry, through the expansion of sales networks and factories across China and abroad, indicates that other adaptable city regions can overcome similar obstacles. The author challenges both the New Regionalism literature focused on local institutions and assets, as well as perspectives that overemphasize the benefits of globalization and global production networks. Journal of Economic Literature, Classification Numbers: O100, O140, O180. 2 figures, 3 tables, 60 references.
Analysis of the Association between ELISA and Nested PCR on Blood and Milk for Mycobacterium avium subsp. paratuberculosis Detection in Holstein Cows

Paratuberculosis is a chronic, infectious disease of ruminants characterized by progressive weight loss and profuse diarrhea. It is caused by the acid-fast bacillus Mycobacterium avium subspecies paratuberculosis (MAP), has a worldwide distribution and is categorized by the OIE as a List B disease that has serious economic impact or is a public health concern. Disease diagnosis is hampered by a lack of sensitive tests. Available methods fail to identify all infected animals, and many produce substantial numbers of false positives and false negatives. This is of particular importance, as they relate to detection of the organism in subclinically infected animals. Several commercial, enzyme-linked immunosorbent assay (ELISA) tests are available, but it is generally accepted that their sensitivity in detecting infected animals is only about 50%. In fact, because of its low sensitivity, the ELISA test is rarely positive in animals under two years of age. Polymerase chain reaction (PCR) tests based on the insertion element IS900 have been the most widely used for MAP identification. However, detection of the etiologic agent is limited by frequency and number of organisms present in the fluid or tissue. A combination of serologic tests, such as ELISA, and agent detection through nested PCR could be a useful strategy to improve the sensitivity of paratuberculosis diagnosis, especially when detectable target levels for each test follow different temporal patterns. The objective of this study was to compare the performance of ELISA testing of sera, and nested PCR in milk and blood, for diagnosis of paratuberculosis in Holstein cows.
Impact and Inclusion: Transforming an EdD Program into a Crucible for Systems Change

This article shares insights from a review of dissertations produced by students in an EdD program in Educational Leadership at a public university in Connecticut. Program curriculum and learning experiences, built upon a social justice platform, prepare students to engage in scholarship and action to improve educational systems. However, retaining students’ focus on designing capstone projects that explore and seek to mitigate systemic injustice has been an ongoing challenge. To understand more about the impact of the EdD program’s vision of developing students’ capacities for systems transformation and social justice, program faculty conducted a document analysis of dissertations produced in the 15 years from program inception to the present, examining themes and trends that emerge from the focus areas, research questions, and research methods applied in dissertations. Document analysis revealed that, while earlier student dissertations tended to be more aligned with the educational policy cycle than with the program’s focus on social justice, more recent dissertations demonstrate a shift toward a stronger social justice orientation. As a member of the Carnegie Project on the Educational Doctorate (CPED) since 2018, this university’s EdD program engages in ongoing redesign to maximize impact on the field and to cultivate activism among program graduates who will lead systemic transformation in education. A conceptual framework for transcendent third-order change - cultivating systems leadership that transcends the limits of current paradigms and action, fosters collaborative engagement, and provides coherent structures for collaborative impact - is the foundation for this redesign.