cssi/SciSciGPT-SciSciNet huggingface dataset:
Some like it lots

This study has four primary purposes: to investigate the level of interactivity with 15 sources of political information, determine the degree of reliance on each of the sources, assess perceptions of credibility, and compare the strength of interactivity to the strength of reliance on judgments of credibility. This study includes sources that have received little attention in the credibility literature such as social network sites, Twitter, and mobile device applications. Respondents interact with and rely on the sources moderately. Credibility ratings range from moderate to highly credible. Reliance predicts credibility of 14 of 15 sources as compared to interactivity that predicts credibility of just 9 of 15 sources. Interactivity with sources that are inherently collaborative (e.g. Twitter, social media, talk radio) more strongly predicts credibility than interactivity with sources that are more source-to-user based (e.g. CNN, political websites). This study explores credibility of 15 sources of political information including mobile device apps.The six most credible sources are all traditional media.Fox News, Twitter and candidate blogs are judged the least credible sources.Reliance is a much better predictor of credibility than interactivity.Interactivity predicts credibility better with collaborative sources (e.g. social media).
The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts

Background Colon and intestinal crypts serve as an important model system for adult stem cell proliferation and differentiation. We develop a spatial stochastic model to study the rate of somatic evolution in a normal crypt, focusing on the production of two-hit mutants that inactivate a tumor suppressor gene. We investigate the effect of cell division pattern along the crypt on mutant production, assuming that the division rate of each cell depends on its location.
Recalibrating Patent Venue

For most of patent law’s 200-year plus history, the rule has been that patentholders are permitted to sue defendants only in the district they inhabit. In 1990, the Federal Circuit ruled that Congress changed this by enlarging the scope of permissible venue to all districts with personal jurisdiction over the defendant. Since then, patentees have flocked to fewer districts, and in 2015, brought more than 40% of their cases in a single rural district with 1% of the US population, the Eastern District of Texas. Fueled in particular by concerns that non-practicing entities (NPEs), who bring the majority of cases in the Eastern District, are abusing venue, several pending Congressional bills and the TC Heartland case, potentially headed for Supreme Court review, could reinstate a more restrictive rule. We add to the policy discussion by reporting on a novel analysis of ~1,500 patent and non-patent cases filed in 2015, to explore how filing patterns might be impacted under different versions of the law. We find that about 86% of 2015 patent cases were brought outside of the defendant’s home district (principal place of business), a strikingly high share. Things would change if venue were reformed, but the specifics would vary based on which reform is implemented – that of the Court (e.g. TC Heartland reform) or Congress (e.g. VENUE Act reform). If the courts decide to restrict venue to where defendant resides or has an established place of business, an estimated 58% of 2015 cases would have had to been filed in a different venue. If Congress decides that cases can also be filed in home districts with research or manufacturing connections to the case, about half the NPE cases in our sample would have to be refiled in an unfamiliar district, but only 14% of the operating company cases would. Cases would leave the Eastern District of Texas, and many, we project, would go to Delaware or California. Under TC Heartland smaller defendants would get more from venue relief than would larger defendants, because of their relatively smaller footprints. Among NPEs, university, individuals and small company NPEs would be impacted to a lesser extent than would PAEs, considerably so under the VENUE Act.
GTAP-E-Power: An Electricity-detailed Economy-wide Model

Global economic analysis of energy and climate policy often uses an aggregate representation of the electricity sector (e.g., GTAP-E). However, disproportionate technological progress and policies across different generating technologies requires a more detailed representation that identifies and allows for substitution between generating technologies. GTAP-E-Power extends the GTAP-E model to include transmission and distribution as well as substitution between nuclear, coal, gas base load, gas peak load, oil base load, oil peak load, hydro base load, hydro peak load, wind, solar, and 'other' power. Electric power substitution is represented with a nested additive constant elasticity of substitution which, opposed to the traditional constant elasticity of substitution, ensures that the sum of demands for generation from each technology is equal to total demand for electricity generation. The primary purpose of GTAP-E-Power is to serve as guidance for implementing the GTAP-Power Data Base in a computable general equilibrium model with substitution between electricity generating technologies to inform economic, energy, and climate policy.
Civil Legal Services and Medical-Legal Partnerships Needed by the Homeless Population: A National Survey.

Objectives. To examine civil legal needs among people experiencing homelessness and the extent to which medical-legal partnerships exist in homeless service sites, which promote the integration of civil legal aid professionals into health care settings.Methods. We surveyed a national sample of 48 homeless service sites across 26 states in November 2015. The survey asked about needs, attitudes, and practices related to civil legal issues, including medical-legal partnerships.Results. More than 90% of the homeless service sites reported that their patients experienced at least 1 civil legal issue, particularly around housing, employment, health insurance, and disability benefits. However, only half of all sites reported screening patients for civil legal issues, and only 10% had a medical-legal partnership. The large majority of sites reported interest in receiving training on screening for civil legal issues and developing medical-legal partnerships.Conclusions. There is great need and potential to deploy ...
Is the Nature of Communication Relevant to the Supportiveness of Women's Relationships With Probation and Parole Agents?

This article reports on a study of the connection of probation and parole agents’ communication with relationship supportiveness as perceived by both women offenders and agents. For a sample of off...
Performance Enhancement of OMP Algorithm for Compressed Sensing Based Sparse Channel Estimation in OFDM Systems

Long duration of the channel impulse response along with limited number of actual paths in orthogonal frequency division multiplexing (OFDM) vehicular wireless communication systems results in a sparse discrete equivalent channel. Implementing different compressed sensing (CS) algorithms enables channel estimation with lower number of pilot subcarriers compared to conventional channel estimation. In this paper, new methods to enhance the performance of the orthogonal matching pursuit (OMP) for CS channel estimation method is proposed. In particular, in a new algorithm dubbed as linear minimum mean square error-OMP (LMMSE-OMP), the OMP is implemented twice: first using the noisy received pilot data as the input and then using a modified received pilot data processed by the outcome of the first estimator. Simulation results show that LMMSE-OMP improves the performance of the channel estimation using the same number of pilot subcarrier. The added computational complexity is studied and several methods are suggested to keep it minimal while still achieving the performance gain provided by the LMMSE-OMP including using compressive sampling matching pursuit (CoSaMP) CS algorithm for the second round and also changing the way the residue is calculated within the algorithm.
A Systematic Review of the Autism Research with Children Who Are Deaf or Hard of Hearing.

The current study is a systematic review on the available evidence on language development, assessment, challenging behavior, and instruction for children dually diagnosed with autism spectrum disorder and deafness. Results indicate a strong need for additional research in these areas, especially in the areas of evidence-based practices.
Women’s and Men’s Prominence in Sports Coverage and Changes in Large-, Medium-, and Small-City Newspapers, Pre- and Post-Title IX: A Local Play for Equality?

Through the lens of agenda-setting theory, this article investigates whether women’s sports coverage in mainstream newspapers increased after the passage of Title IX, consistent with the expectatio...
Metabolic Abnormalities Detected in Phase II Evaluation of Doxycycline in Dogs with Multicentric B-Cell Lymphoma.

Doxycycline has anti-proliferative effects in human lymphoma cells and in murine xenografts. We hypothesized doxycycline would decrease canine lymphoma cell viability and prospectively evaluated its clinical tolerability in client-owned dogs with spontaneously-occurring, nodal, multicentric, substage a, B-cell lymphoma, not previously treated with chemotherapy. Treatment duration ranged from 1 – 8 weeks (median and mean, 3 weeks). Dogs were treated with either 10 mg/kg (n=6) or 7.5 mg/kg (n=7) by mouth twice daily. One dog had stable disease for 6 weeks. No complete or partial tumor responses were observed. Five dogs developed grade 3 and/or 4 metabolic abnormalities suggestive of hepatopathy with elevations in bilirubin, ALT, ALP, and/or AST. To evaluate absorption of oral doxycycline in our study population, serum concentrations in 10 treated dogs were determined using liquid chromatography tandem mass spectrometry. Serum levels were variable and ranged from 3.6 – 16.6 μg/ml (median, 7.6 μg/ml; mean, 8.8 μg/ml). To evaluate the effect of doxycycline on canine lymphoma cell viability in vitro, trypan blue exclusion assay was performed on canine B-cell lymphoma cell lines (17-71 and CLBL) and primary B-cell lymphoma cells from nodal tissue of 4 dogs. A doxycycline concentration of 6 μg/ml decreased canine lymphoma cell viability by 80%, compared to matched, untreated, control cells (mixed model analysis, p<0.0001; Wilcoxon signed rank test, p=0.0313). Although short term administration of oral doxycycline is not associated with remission of canine lymphoma, combination therapy may be worthwhile if future research determines that doxycycline can alter cell survival pathways in canine lymphoma cells. Due to the potential for metabolic abnormalities, close monitoring is recommended with use of this drug in tumor-bearing dogs. Additional research is needed to assess the tolerability of chronic doxycycline therapy.
Environmental Stress and Myocardial Reactivity

This study tested aspects of a new theory (Kelsey, 1986) of the etiology and pathophysiology of primary Raynaud’s phenomenon. Raynaud’s phenomenon is defined as an episode of vasoconstriction, or vasospasm, of the small cutaneous arteries and arterioles in the extremities that causes a severe reduction in blood flow and a corresponding decrease in temperature in the skin of affected areas (Coffman & Davies, 1975; Gifford & Hines, 1957). These vasospastic episodes usually affect the fingers, causing them to turn cold, numb, and white; thus, Raynaud’s phenomenon is characterized as “episodic vasospastic ischemia of the digits” (Halperin & Coffman, 1979, p. 89). The phenomenon is further classified into primary and secondary forms. Primary Raynaud’s phenomenon, also known as Raynaud’s disease, refers to idiopathic manifestations of the disorder, whereas secondary Raynaud’s phenomenon refers to manifestations of the disorder that are symptomatic of an underlying primary disease, such as scleroderma.
Stability and Instability of Detonation Waves

We study nonlinear stability and instability of detonation waves through a dynamic model which includes nonlinear convection, chemical reaction, weak curvature effect and induction kinetics. The stability of the plane and the divergent detonation waves were established rigorously when there is no induction-zone. Furthermore, when the wave front has a small positive curvature and when there is an induction-zone behind the shock front, we captured dynamically unstable solutions through numerical simulations. The unstable solutions are accompanied by velocity fluctuations.
Ethnic Crossroads: Visualizing Urban Narratives

Charles Taylor in „The Politics of Recognition“ writes: „Equal recognition is not just the appropriate mode for a healthy democratic society. Its refusal can inflict damage on those who are denied it.“ He continues, „The projection of an inferior or demeaning image on another can actually distort and oppress, to the extent that the image is internalized“ (Taylor 1994: 36). This sensitivity to the power of images is central to my approach to teaching about diversity. Showing how a shared sense of community is possible in multicultural societies has been a perennial quest for my mentor Feliks Gross (1999) and me.
Carbon Based Materials on SiC for Advanced Biomedical Applications

The method of detection for numerous biomedical devices is based on electrical stimulation, which requires an electrode material to be in contact with the biological system. Metal electrodes have been mainly the material of choice but they produce faradic currents and other phenomena that affect the device performance. Currently, carbon-based materials are considered promising alternatives to metallic electrodes because they combine good biocompatibility with high chemical resistance and good electrochemical properties. In this work we present an overview of the fabrication and characteristics of graphene and pyrolyzed photoresist films (PPF) for biomedical applications. In addition, an initial assessment of the in-vitro biocompatibility of epitaxial graphene on 6H-SiC(0001) and PPF with human keratinocytes (HaCaT) cells is presented.
Parent attitudes toward immunizations and healthcare providers the role of information.

Background Lack of information has been associated with patient anxiety or concern in a number of healthcare areas. Objectives (1) Identify the proportion of parents who agreed, were neutral, and disagreed that they had access to enough information to make a decision about immunizing their child; (2) examine how parents who agreed and disagreed differed with respect to sociodemographic characteristics, and their attitudes about immunizations, their child's healthcare provider, immunization requirements/exemptions, and immunization policymakers; and (3) identify if differences exist in specific immunization concerns. Methods A sample of parents with at least one child aged ≤6 years ( n =642) was analyzed using data from the HealthStyles survey conducted during July and August 2003. Odds ratios and the Mantel-Haenszel chi-square test were used for analysis. Results Response rate for HealthStyles was 69% (4035/5845). The largest proportion of parents agreed they had access to enough information (67%) compared to parents who were neutral (20%) or who disagreed (13%). Compared to parents who agreed, parents who disagreed were more likely to be less confident in the safety of childhood vaccines (odds ratio [OR]=5.4, 95% confidence interval [CI]=3.3–8.9), and to disagree that their child's main healthcare provider is easy to talk to (OR=10.3, 95% CI=3.7–28.1). There was a significant linear trend in the percentage of parents expressing immunization concerns among those who agreed, were neutral, and who disagreed they had access to enough information ( p Conclusions While most parents agreed that they had access to enough immunization information, approximately a third did not. Perceived lack of information was associated with negative attitudes about immunizations and toward healthcare providers. Basic information about the benefits and risks of vaccines presented by a trusted provider could go a long way toward maintaining and/or improving confidence in the immunization process.
Bottom-up Lawmaking Through a Pluralist Lens: The ICC Banking Commission and the Transnational Regulation of Letters of Credit

The international lawmaking stories that gain scholarly and popular traction are generally of a similar "top-down" genre, centering on state-based policymakers and contemplating treaties or intergovernmental institutions. Yet, much international law surfaces from the "bottom-up," from day-to-day private and commercial practices. This Article deploys core legal pluralism insights to narrate a rich bottom-up lawmaking tale that features private bankers, who have coalesced for decades under the auspices of the International Chamber of Commerce's Banking Commission to "codify" letter-of-credit practices in the form of the Uniform Customs and Practices (UCP). The UCP, however, is not mere self-regulation but rather a potent determinant of hard law, in this instance a multilateral treaty and Article 5 of the Uniform Commercial Code. This Article argues that bottom-up lawmaking sculpts the legal landscape as much as any treaty or diplomatic conference and thereby challenges prevailing international legal theory.
Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells

Piezo1 is a mechanosensitive (MS) ion channel with characteristic fast-inactivation kinetics. We found a slowly-inactivating MS current in mouse embryonic stem (mES) cells and characterized it throughout their differentiation into motor-neurons to investigate its components. MS currents were large and slowly-inactivating in the stem-cell stage, and became smaller and faster-inactivating throughout the differentiation. We found that Piezo1 is expressed in mES cells, and its knockout abolishes MS currents, indicating that the slowly-inactivating current in mES cells is carried by Piezo1. To further investigate its slow inactivation in these cells, we cloned Piezo1 cDNA from mES cells and found that it displays fast-inactivation kinetics in heterologous expression, indicating that sources of modulation other than the aminoacid sequence determine its slow kinetics in mES cells. Finally, we report that Piezo1 knockout ES cells showed a reduced rate of proliferation but no significant differences in other markers of pluripotency and differentiation.
A multidimensional view of racial differences in access to prostate cancer care.

e18048Background: Racial differences in prostate cancer treatment and outcomes are widespread and poorly understood. We sought to determine whether access to care, measured across multiple dimensio...
Imparting sensitivity and selectivity to a gold nanoparticle chemiresistor through thiol monolayer functionalization for sensing acetone

Chemiresistor-based gas sensors for detection of target volatile organic compounds (VOCs) in air face common challenges of poor sensitivity and selectivity as well as suffering from interference by other constituent gases and/or humidity. This work demonstrates that functionalizing gold nanoparticles (AuNPs) with a designed thiol monolayer improves sensitivity and selectivity of the derived AuNPs gas sensor. We report the synthesis and application of a thiol ligand fitted with both a urea motif and a tert-butyl end group for functionalizing AuNPs. The AuNPs sensor prepared using the urea thiol ligand demonstrated significantly increased acetone sensing in comparison with tested commercially available thiol-functionalized AuNPs. The sensor worked under ambient temperature and high humidity conditions, and demonstrated a linear relationship between the sensor response and the common logarithm of analyte concentration.
Parenchyma, Collenchyma, and Sclerenchyma

The plant body plan is quite simple, encompassing four organs (leaf, stem, root, flower), three basic tissue types (epidermal, vascular and ground), and three cell types (parenchyma, collenchyma, and sclerenchyma). Parenchyma cells are living cells, bound by a primary cell wall, and many of them are capable of differentiation into any other cell type. Parenchyma is the most diverse and versatile cell type and comprises the majority of cells in most plants. Collenchyma cells are the least common plant cell type. They have a primary cell wall and provide support in herbaceous or temporary organs such as petioles and leaves. Sclerenchyma cells have a lignified and strong secondary cell wall and are usually dead at maturity. Sclerenchyma cells are found wherever a plant needs strength and support, such as fibers, stone cells, wood, and water-conducting cells.
Sleep-Disordered Breathing in Children

1. Kevin Gipson, MD, MS* 2. Mengdi Lu, MD* 3. T. Bernard Kinane, MD* 1. *Division of Pediatric Pulmonology and Sleep Medicine, Department of Pediatrics, Massachusetts General Hospital for Children and Harvard Medical School, Boston, MA * Abbreviations: AAP: : American Academy of Pediatrics AHI: : apnea-hypopnea index AT: : adenotonsillectomy Bi-level: : bilevel positive airway pressure CPAP: : continuous positive airway pressure CSA: : central sleep apnea FDA: : Food and Drug Administration OSA: : obstructive sleep apnea PAP: : positive airway pressure PSG: : polysomnography SDB: : sleep-disordered breathing An estimated 1% to 5% of children have sleep-disordered breathing related to obstructive sleep apnea, with a smaller proportion of children having central or mixed sleep apnea. Improved screening for sleep-disordered breathing in the general pediatrics clinic, coupled with effective management strategies, has the potential to have wide-ranging benefits on the patient’s long-term health and development. After completing this article, readers should be able to: 1. Recognize the signs and symptoms of obstructive sleep apnea in pediatric and adolescent patients. 2. Understand the role of in-laboratory sleep studies in the evaluation of pediatric patients with suspected sleep-disordered breathing. 3. Weigh the indications, benefits, and risks of various therapies for obstructive sleep apnea. 4. Have a general understanding of, and maintain an appropriate index of suspicion for, comorbid central sleep apnea when a patient presents with signs of sleep-disordered breathing. Sleep is central to a healthy childhood, and sleep-disordered breathing (SDB)—the disruption of normal respiratory patterns and ventilation during sleep—is implicated in several behavioral and physical health issues. Although we now have strong evidence that chronic, unchecked obstructive sleep apnea (OSA) can lead to hypertension, cardiovascular disease, metabolic disorders, obesity, and neuropsychiatric and developmental issues, the full scope of the effect of SDB on health remains underappreciated by many clinicians (Table 1). View this table: Table 1. Disease States Associated with or Complicated by Chronic Sleep-Disordered Breathing Sleep research has rapidly expanded and evolved in the past few decades. Of recent note, chronobiologists Hall, Rosbash, and Young received the 2017 Nobel prize in medicine for their work on the cell’s internal clock. While the biological role of sleep remains mysterious, as famed researcher Allan Rechtschaffen once remarked, “If sleep …
Building a Successful Voice Telepractice Program.

Purpose Telepractice offers prevention, assessment, treatment, and consultation at a distance. This article provides an overview of telepractice with specific considerations and examples related to...
Patterns, Profiles, and Parsimony: dissecting transcriptional signatures from minimal single-cell RNA-seq output with SALSA

Single-cell RNA sequencing (scRNA-seq) technologies have precipitated the development of bioinformatic tools to reconstruct cell lineage specification and differentiation processes with single-cell precision. However, start-up costs and data volumes currently required for statistically reproducible insight remain prohibitively expensive, preventing scRNA-seq technologies from becoming mainstream. Here, we introduce single-cell amalgamation by latent semantic analysis (SALSA), a versatile workflow to address those issues from a data science perspective. SALSA is an integrative and systematic methodology that introduces matrix focusing, a parametric frequentist approach to identify fractions of statistically significant and robust data within single-cell expression matrices. SALSA then transforms the focused matrix into an imputable mix of data-positive and data-missing information, projects it into a latent variable space using generalized linear modelling, and extracts patterns of enrichment. Last, SALSA leverages multivariate analyses, adjusted for rates of library-wise transcript detection and cluster-wise gene representation across latent patterns, to assign individual cells under distinct transcriptional profiles via unsupervised hierarchical clustering. In SALSA, cell type assignment relies exclusively on genes expressed both robustly, relative to sequencing noise, and differentially, among latent patterns, which represent best-candidates for confirmatory validation assays. To benchmark how SALSA performs in experimental settings, we used the publicly available 10X Genomics PBMC 3K dataset, a pre-curated silver standard comprising 2,700 single-cell barcodes from human frozen peripheral blood with transcripts aligned to 16,634 genes. SALSA identified at least 7 distinct transcriptional profiles in PBMC 3K based on <500 differentially expressed Profiler genes determined agnostically, which matched expected frequencies of dominant cell types in peripheral blood. We confirmed that each transcriptional profile inferred by SALSA matched known expression signatures of blood cell types based on surveys of 15 landmark genes and other supplemental markers. SALSA was able to resolve transcriptional profiles from only ~9% of the total count data accrued, spread across <0.5% of the PBMC 3K expression matrix real estate (16,634 genes x 2,700 cells). In conclusion, SALSA amalgamates scRNA-seq data in favor of reproducible findings. Furthermore, by extracting statistical insight at lower experimental costs and computational workloads than previously reported, SALSA represents an alternative bioinformatics strategy to make single-cell technologies affordable and widespread.
Impact of BRAF mutation in patients with brain metastasis from melanoma.

e13016 Background: Melanoma patients with brain metastasis (MBM) have a dismal prognosis.BRAF mutation occurs in approximately 50% of patients with metastatic melanoma; however its impact on MBM ou...
Synthesis of Titanium, Zirconium, and Hafnium Complexes that Contain Diamido Donor Ligands of the Type [(t-BuN-o-C6H4)2O]2- and an Evaluation of Activated Versions for the Polymerization of 1-Hexene

Titanium, zirconium, and hafnium dialkyl complexes that contain the [(t-Bu-d6−N-o-C6H4)2O]2- ([t-BuNON]2-) ligand have been prepared. Only [t-BuNON]TiMe2 could be isolated, but [t-BuNON]ZrR2 and [t-BuNON]HfR2 complexes could be isolated in which (for example) R = Me, Et, or i-Bu. X-ray studies showed [t-BuNON]MMe2 structures (M = Ti or Zr) to be of the “twisted fac” variety in which two amido nitrogens occupy equatorial positions in a distorted trigonal bipyramid. However, in solution all such species show equivalent alkyl groups on the NMR time scale as a consequence of formation of an intermediate mer structure that contains a planar oxygen donor. In analogous complexes that contain the {[Me(CD3)2CNC6H4][Me(CD3)2CN-2,4-Me2C6H2]O}2- or {[Me(CD3)2CNC6H4][Me(CD3)2N-2-EtC6H3]O}2- ligand the two metal alkyl groups are inequivalent on the NMR time scale. Addition of trimethylphosphine to [t-BuNON]Zr(CH2CH3)2 yields structurally characterized, pseudooctahedral [t-BuNON]Zr(η2-C2H4)(PMe3)2. Addition of B(C6F5)3 ...
The Inflammatory Bowel Disease Medical Home: From Patients to Populations

With increasing emphasis on cost reduction and quality improvement, the transition to value-based care is underway. New models of health care delivery are being explored to optimize patient experience and outcomes while decreasing health care expenses. One such model is the specialty medical home (SMH), which provides multidisciplinary, high-quality care for chronic diseases with specialist involvement, such as inflammatory bowel disease (IBD). This review aims to explore the rationale behind initial construction, the critical personnel and components, the early outcomes of established models, comparison with other value-based care models, and the role of an IBD SMH in population health management.
Simulation Accuracy, Uncertainty, and Predictive Capability: A Physical Sciences Perspective

Most computational analysts, as well as most governmental policy-makers and the public, view computational simulation accuracy as a good agreement of simulation results with empirical measurements. However, decision-makers, such as business managers and safety regulators who rely on simulation for decision support, view computational simulation accuracy as much more than agreement of simulation results with experimental data. Decision-makers’ concept of accuracy is better captured by the term predictive capability of the simulation. Predictive capability meaning the use of a computational model to foretell or forecast the response of a system to conditions without available experimental data, even for system responses that have never occurred in nature. This chapter makes this important distinction by discussing the crucial ingredients needed for predictive capability: code verification, solution (or calculation) verification, model validation, model calibration, and predictive uncertainty estimation. Each of these ingredients is required, whether the simulation results are used in the generation of new knowledge, or for decision support by business managers, government policy-makers, or safety regulators.
Age-Associated Risk of 90-Day Postoperative Mortality After Cytoreductive Surgery for Advanced Ovarian Cancer

This study explores the association of the risk of 90-day mortality with age for US women with advanced ovarian cancer undergoing cytoreductive surgery.
Small Business Owners Handle Website Design Effectively Using Gamification

Regardless of how big or small the business, technological advancements, such as building an efficient website, should be of great concern for business owners due to the technological dominance in the current society. Web design describes the process of creating a website, and embodies many different aspects such as webpage layout, content production, and graphic design. However, there are many obstacles that small business owners face when developing their websites, such as not having enough time, lacking technical skills, or difficulties with the content itself. This study tries to apply gamification design in the website education area to support and help small business owners in business web development. Additionally, Gamification describes the process of using game elements in non-game settings to engage the audience. Thus, a website development guideline is proposed in a game style model. The benefit of using the Gamification Theory in business is that it will help keep the audience engaged, and will make the process of development feasible, engaging, and less time consuming. This study will support business owners both short term as well as long term.
Accommodating More Users in Highway Electric Vehicle Charging through Coordinated Booking: A Market-Based Approach

This paper presents a coordinated booking mechanism for highway electric vehicle charging management. The mechanism improves charging facility utilization and user satisfaction through coordinating users' charging schedules based on their travel time flexibility and required charging time for their trip. Given that users compete for limited charging resources to obtain their preferred schedules, we model them as self-interested agents who consider their flexibility as their private information and may be reluctant to reveal it to the scheduler. In order to compute high-quality schedules, we propose a market-based scheduling mechanism which motivates users to reveal their flexibility. This mechanism is implemented using an iterative bidding procedure which allows users to progressively reveal their feasible travel time windows as needed. The goal is to maximize the number of served users given limited charging capacity and users' travel time window constraints. Our computational study shows that the proposed booking mechanism achieves on average 90% efficiency compared with optimal solutions. We also observe that high efficiency solutions usually require more flexibility information to be revealed by the users.
Improving Marrow Collections By Use of Five Side Hole Needle

Authors Harvey, E., Abhyankar, S., Merkel, D, Shune, L. Objectives Marrow harvesting is used to treat both malignant and nonmalignant hematologic disorders. We describe here our method of decreasing both anesthesia and collection times and maintaining or improving the total nucleated cell dose of the product. Method We analyzed 227 marrow harvest between October 2010 and August 2018. From the period of October 2010 through July 2018, we utilized the standard aspirate/biopsy needle. Total number of harvests during this time was 167. Starting in August of 2018, we switched to a 5-side hole marrow harvest needle. Total number of harvest utilizing this needle was 60. Counts were checked midway during all harvests and again close to estimated completion to verify stopping point. Results Anesthesia time for donors decreased 27% from an average of 83 minutes to 61 minutes (44 minimum- 96 maximum). Total harvest time was decreased by 32%, from an average of 44 minutes with the single hole needles to 30 minutes with the five side hole needs. (11 minimum – 66 maximum) (32% decrease). Total nucleated cell dose averaged 4.91 × 108/kg with the use of the single hole needs (n=167) and with the 5-side hole needles the average was 5.13 × 10 8 (N=60) Conclusion Changing from the single hole needle to the five (5) side hole needle improved the efficiency of the marrow harvest from both the collection and an anesthesia timepoints. By decreasing the anesthesia and collection times, we minimize the overall effects of the collection procedure on the donor. Traditional single hole beveled needle on left, 5 side hole needle on right. Close-ups of 5 Side Hole Needle
Time Factor and the Genesis of Soils on Early Wisconsin Till1,2

Radiocarbon dates indicate that the maximum time of weathering for soils of the Tazewell substage may be about 6400 years longer than that available for weathering of soils of the Cary substage. Detailed mineralogical and chemical studies were made of the 2–0.2 μ fractions of 0–6 in. and 30–36 in. samples from 24 sites along a traverse extending from the Cary substage across the Tazewell substage in east-central Indiana. The major clay mineral constituents of the 0–6 in. samples were illite and 14 A material; illite and montmoril-lonite were the main components in the 30–36 in. samples. The correlation coefficients between illite content and percentage K2O for the 0–6 in. and 30–36 in. samples were 0.85 and 0.92, respectively. The end and terminal moraines of the Tazewell substage were found to have a higher illite content than the ground moraines. This was attributed to superglacial movement and enrichment of foreign materials, i.e. mica schists from the Canadian shield, on end and terminal moraines. The results of saturation of the clay fraction with potassium and magnesium on the proportion of 10A, 12.7A and 14A spacings indicated that weathering had lowered the surface charge density of the micaceous minerals in the 0–6 in. samples to a greater extent than in the 30–36 in. samples. This effect, in addition to other weathering reactions, resulted in partially expanded micaceous minerals in the 0–6 in. samples which were much more resistant to collapse than were the minerals in the 30–36 in. samples. The rate of weathering of K2O from the 2–0.2μ fraction of the 0–6 in. samples located on ground moraines was estimated to be about 0.1 percent per 1000 years. This value was used in estimating the ages of the morainie systems of the Tazewell in Indiana. The estimated ages were as follows: Mississinewa, (radiocarbon date) 13,140 years; Union City, 14,500 years; Bloomington, 15,500 years; Champaign, 18,700 years; Shelbyville, (radiocarbon date) 19,500 years. The fertility status of the soils on the Tazewell has been influenced appreciably by the length of the weathering period, the potassium-supplying power of the soils decreasing with increasing age.
Physics-inspired deep learning to characterize the signal manifold of quasi-circular, spinning, non-precessing binary black hole mergers

Abstract The spin distribution of binary black hole mergers contains key information concerning the formation channels of these objects, and the astrophysical environments where they form, evolve and coalesce. To quantify the suitability of deep learning to estimate the individual spins, effective spin and mass-ratio of quasi-circular, spinning, non-precessing binary black hole mergers, we introduce a modified version of WaveNet trained with a novel optimization scheme that incorporates general relativistic constraints of the spin properties of astrophysical black holes. The neural network model is trained, validated and tested with 1.5 million l = | m | = 2 waveforms generated within the regime of validity of NRHybSur3dq8 , i.e., mass-ratios q ≤ 8 and individual black hole spins | s | { 1 , 2 } z ≤ 0.8 . To reduce time-to-insight, we deployed a distributed training algorithm at the IBM Power9 Hardware-Accelerated Learning cluster at the National Center for Supercomputing Applications to reduce the training stage from 1 month, using a single V100 NVIDIA GPU , to 12.4 hours using 64 V100 NVIDIA GPUs . We have also fully trained this model using 1536 V100 GPUs (256 nodes) in the Summit supercomputer at Oak Ridge National Laboratory, achieving state-of-the-art accuracy within just 1.2 hours. Using this neural network model, we quantify how accurately we can infer the astrophysical parameters of black hole mergers in the absence of noise. We do this by computing the overlap between waveforms in the testing data set and the corresponding signals whose mass-ratio and individual spins are predicted by our neural network. We find that the convergence of high performance computing and physics-inspired optimization algorithms enable an accurate reconstruction of the mass-ratio and individual spins of binary black hole mergers across the parameter space under consideration. This is a significant step towards an informed utilization of physics-inspired deep learning models to reconstruct the spin distribution of binary black hole mergers in realistic detection scenarios.
Risk of Adverse Cardiovascular Events in Cardiac Sarcoidosis Independent of Left Ventricular Function.

This study investigated the association between left ventricular ejection fraction (LVEF) and the risk of ventricular arrhythmias (VA), heart transplantation, and death in cardiac sarcoidosis (CS). We identified 110 CS patients meeting 2014 Heart Rhythm Society (HRS) diagnostic criteria with baseline LVEF In conclusion, patients with CS experience high rates of VA, SCD, and heart transplantation, even when LVEF is mildly impaired or normal. Patients with LVEF
Limitations of current traffic models and strategies to address them

Abstract Traffic flow modeling has evolved over a few decades with numerous models at the macroscopic and microscopic levels being proposed. It appears that traffic flow modeling has been adequately addressed and it is natural to ask if there is still any gap to fill or any room to improve. After examining existing models and comparing them against ideal outcomes, we identified four limitations in both traffic flow theory and simulation, namely (1) the lack of model consistency among macroscopic models and between microscopic and macroscopic models, (2) the lack of model flexibility to admit driver heterogeneity, (3) the lack of model capability to look ahead into the near future, and (4) the lack of model expandability beyond one dimensional traffic. Strategies to address these limitations are proposed with emphasis on general approaches rather than proposing specific models.
The Implementation of Screening for Adverse Childhood Experiences in Pediatric Primary Care.

Objective To assess the implementation of screening, screening rates, and prevalence of adverse childhood experiences (ACEs) in a large integrated healthcare system. Study design Kaiser Permanente Southern California is a large integrated healthcare system with 15 medical centers/hospitals and 233 medical office buildings that serve approximately 1.5 million children. Screening for ACEs began in July 2018 at 1 medical center (Downey, Bellflower medical office) for 3- and 5-year-old well-child visits (yearly physical examination). It quickly expanded to 3 other medical centers (6 clinics in total) and now also includes the 10- and 13-year-old well-child visits. Results Since July 2018 we have screened 3241 3-year-olds (53% of the target population), 2761 5-year-olds (53%), 545 10-year-olds (37%), and 509 13-year-olds (13%). Of the 3-year-olds who were screened, 15% had an ACEs score of 1 or higher. Of the 5-year-olds that were screened, 17.5% had an ACEs score of 1 or higher. Of the 10-year-olds, 30.5% had an ACEs score of 1 or higher and of the 13-year-olds, 33.8% had an ACEs score of 1 or higher. Conclusions Although we have encountered some challenges, particularly with follow-up for those screening positive for ACEs, screening was feasible. The data show an increasing trend of ACEs in 3- to 13-year-old children, highlighting the need for early education about ACEs to mitigate the effects of toxic stress.
Imperial Creditors, ‘Doubtful’ Nationalities and Financial Obligations in Late Ottoman Syria: Rethinking Ottoman Subjecthood and Consular Protection

This article examines the ways in which Ottoman subjecthood and foreign protection were practiced and perceived by imperial financiers and officials following the nationality legislation of the 186...
Does Bariatric Binge‐Eating Size Matter? Conceptual Model and Empirical Support

Objective Bariatric surgery affects the quantity of food individuals can eat, yet some individuals still experience loss of control (LOC) while eating. This cross-sectional study examined a new classification system for binge/LOC eating following bariatric surgery. Methods A total of 168 individuals who underwent bariatric surgery 6 months earlier and reported LOC eating were administered the Eating Disorder Examination-Bariatric Surgery Version interview and self-report measures of depressive symptoms, functional impairment, and physical and mental health-related quality of life. Three groups were created based on the largest LOC-eating episode determined by the Eating Disorder Examination-Bariatric Surgery Version interview as follows: (1) "traditional" objective binge-eating episodes, defined as eating unusually large quantities of food while having LOC; (2) "bariatric-objective binge eating," meaning unusually large quantities for postsurgical bariatric patients with LOC; and (3) "bariatric-subjective binge eating," meaning small quantities of food with LOC after surgery. Results In total, 75% (n = 126) met criteria for the bariatric-objective binge episodes group, 10% (n = 17) met criteria for the traditional objective binge-eating group, and 15% (n = 25) met criteria for the bariatric-subjective binge episodes group. The three groups differed significantly, with a graded pattern by binge size, in global eating-disorder psychopathology, depressive symptoms, and functional impairment but not quality of life. Conclusions These findings provide empirical support for a new classification system for bariatric binge/LOC eating. Binge size was associated with distinct psychopathology. Longitudinal follow-up is needed to ascertain effects on clinical outcomes.
Trends in place of early-season influenza vaccination among adults, 2014-15 through 2018-19 influenza seasons—The importance of medical and nonmedical settings for vaccination

Background Annual vaccination is the most effective strategy for preventing influenza. We assessed trends and demographic and access-to-care characteristics associated with place of vaccination in recent years. Methods Data from the 2014-2018 National Internet Flu Survey were analyzed to assess trends in place of early-season influenza vaccination during the 2014-15 through 2018-19 seasons. Multivariable logistic regression was conducted to identify factors independently associated with vaccination settings in the 2018-19 season. Results Among vaccinated adults, the proportion vaccinated in medical (range: 49%-53%) versus nonmedical settings (range: 47%-51%) during the 2014-15 through 2018-19 seasons were similar. Among adults aged ≥18 years vaccinated early in the 2018-19 influenza season, a doctor's office was the most common place (34.4%), followed by pharmacies or stores (32.3%), and workplaces (15.0%). Characteristics significantly associated with an increased likelihood of receipt of vaccination in nonmedical settings among adults included household income ≥$50,000, having no doctor visits since July 1, 2018, or having a doctor visit but not receiving an influenza vaccination recommendation from the medical professional. Conclusions Place of early-season influenza vaccination among adults who reported receiving influenza vaccination was stable over 5 recent seasons. Both medical and nonmedical settings were important places for influenza vaccination. Increasing access to vaccination services in medical and nonmedical settings should be considered as an important strategy for improving vaccination coverage.
Quasar Black Hole Mass Estimates in the Era of Time Domain Astronomy

We investigate the dependence of the normalization of the high-frequency part of the X-ray and optical power spectral densities (PSD) on black hole mass for a sample of 39 active galactic nuclei (AGN) with black hole masses estimated from reverberation mapping or dynamical modeling. We obtained new Swift observations of PG 1426+015, which has the largest estimated black hole mass of the AGN in our sample. We develop a novel statistical method to estimate the PSD from a lightcurve of photon counts with arbitrary sampling, eliminating the need to bin a lightcurve to achieve Gaussian statistics, and we use this technique to estimate the X-ray variability parameters for the faint AGN in our sample. We find that the normalization of the high-frequency X-ray PSD is inversely proportional to black hole mass. We discuss how to use this scaling relationship to obtain black hole mass estimates from the short time-scale X-ray variability amplitude with precision ~ 0.38 dex. The amplitude of optical variability on time scales of days is also anti-correlated with black hole mass, but with larger scatter. Instead, the optical variability amplitude exhibits the strongest anti-correlation with luminosity. We conclude with a discussion of the implications of our results for estimating black hole mass from the amplitude of AGN variability.
An Analysis of Haydn Wood’s Mannin Veen as It Relates to Manx Folk Songs and Legends From the Isle of Man:

Haydn Wood (1882–1959) was an English composer raised on the Isle of Man. His compositional strengths lay in melodic writing and scoring, and he is best remembered as a composer of British light mu...