cssi/SciSciGPT-SciSciNet huggingface dataset:
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase

Arachidonate 12-lipoxygenase (LOX) converts arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid (HETE), a bioactive lipid implicated in tumor angiogenesis, growth, and metastasis. Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma. However, little is known about the impact of the altered expression or activity of 12-LOX on tumor metastasis. In the present study, we examined whether or not an increase in 12-LOX expression in human prostate carcinoma cells can modulate their metastatic potential. We report that increased expression of 12-LOX in PC-3 cells caused a significant change in cell adhesiveness, spreading, motility, and invasiveness. Specifically 12-LOX transfected PC-3 cells were more adhesive toward vitronectin, type I and IV collagen, but not to fibronectin or laminin, than cells transfected with control vector. Increased spreading on vitronectin, fibronectin, collagen type I and IV also was observed in 12-LOX transfected PC-3 cells when compared to control PC-3 cells. The increased spreading of 12-LOX transfected PC-3 cells was blocked by treatment with 12-LOX inhibitors, baicalein and CDC. 12-LOX transfected PC-3 cells were more invasive through Matrigel than cells transfected with control vector. In vivo, tumor cell invasion to surrounding muscle or fat tissues was more frequent in nude mice bearing s.c. tumors from 12-LOX transfected PC-3 cells than in those from control vector transfected cells. When injected via the tail vein into SCID mice with implanted human bone fragments, there was an increase in tumor metastasis to human bone by 12-LOX transfected PC-3 cells in comparison to control vector transfected cells. Taken together, our data suggest that an increase in 12-LOX expression enhances the metastatic potential of human prostate cancer cells.
Technological advancement, learning, and the adoption of new technology

Abstract This research focuses attention upon three related issues: the persistence of technological progress over time, multiple adoption decisions over a long horizon, and the impact of production based learning on those decisions. We develop a simple economic model for a single product producing firm incorporating continuous technological progress, linear product demand, linear switching costs, and experience based cost reductions. A dynamic programming framework is used to evaluate cases where either one or an unlimited number of adoptions are allowed over an infinite horizon. Both structural and numerical results are presented. Fundamental results serve to explain several counter-intuitive dynamics. In the single adoption case, faster rates of technological progress, as well as growing markets, or a steeply sloping demand curve, serve to delay adoption while an increased ability to learn may accelerate it. When multiple adoptions are allowed, the adoption of any particular technology presents a “window of opportunity” in which future investment will be warranted. If, for whatever reason, this window has passed, then maintaining the older technology becomes more attractive than adoption. Thus, seemingly outdated technologies may remain embedded in some settings.
Immigration into Europe: Economic Discrimination, Violence, and Public Policy

Immigration has irreversibly changed Western European demographics over the past generation. This article reviews recent research drawing implications of this migration for labor-market discrimination and for immigrant–state and immigrant–native violence. It further reports on research measuring the effects of political institutions and policy regimes on reducing the barriers to immigrants' economic integration. In the course of reviewing the literature, we discuss some of the methodological challenges that scholars have not fully confronted in trying to identify the causes and consequences of discrimination and violence. In doing so, we highlight that future work needs to pay greater attention to sequencing, selection, and demographic effects. Further, we suggest ways to resolve contradictory findings in regard to preferred policies aimed at advancing immigrants' economic performance.
Models for asymptotic size distributions for atmospheric aerosols

Abstract Two models for the asymptotic size distribution of atmospheric aerosols are examined. One of these models assumes condensation to be the dominant growth process for atmospheric aerosol particles greater than approximately 0.1 μ. The model yields various characteristic distributions which resemble Rosin-Rammler distributions. In the second model, the theory of stable distributions is used to show that a power law or Paretian asymptotic size distribution is preserved during subsequent alterations such as condensation and coagulation provided the elements undergoing these processes are themselves independently and identically distributed in the domain of attraction of certain positive stable laws.
Tellington Touch before Venipuncture: An Exploratory Descriptive Study

Tellington touch (ttouch) is an emerging natural healing modality used by nurses and other health care providers to communicate caring and connection to clients. This simple-to-learn and easy-to-implement form of mindful, gentle physical touch is said to help in diverse areas such as chronic pain management, labor discomfort, and postinjury pain and edema. Despite 15 years of anecdotal evidence outlining reported benefits for humans, no investigation of ttouch has yet been undertaken. This qualitative study initiates a body of knowledge about ttouch by exploring and describing the experience of ttouch when administered to healthy people awaiting a routine venipuncture. The study includes qualitative data from both the participants (n = 47) and the provider (n = 1) and provides essential foundational information regarding the experience of ttouch. Implications for practice and future research are provided.
Evaluation of conditions along the grounding line of temperate marine glaciers: An example from Muir Inlet, Glacier Bay, Alaska

Abstract In the marine environment, stability of the glacier terminus and the location of subglacial streams are the dominant controls on the distribution of grounding-line deposits within morainal banks. A morainal bank complex in Muir Inlet, Glacier Bay, SE Alaska, is used to develop a model of terminus stability and location of subglacial streams along the grounding line of temperate marine glaciers. This model can be used to interpret former grounding-line conditions in other glacimarine settings from the facies architecture within morainal bank deposits. The Muir Inlet morainal bank complex was deposited between 1860 A.D. and 1899 A.D., and historical observations provide a record of terminus positions, glacial retreat rates and sedimentary sources. These data are used to reconstruct the depositional environment and to develop a correlation between sedimentary facies and conditions along the grounding line. Four seismic facies identified on the high-resolution seismic-reflection profiles are used to interpret sedimentary facies within the morainal bank complex. Terminus stability is interpreted from the distribution of sedimentary facies within three distinct submarine geomorphic features, a grounding-line fan, stratified ridges, and a field of push ridges. The grounding-line fan was deposited along a stable terminus and is represented on seismic-reflection profiles by two distinct seismic facies, a proximal and a distal fan facies. The proximal fan facies was deposited at the efflux of subglacial streams and indicates the location of former glacifluvial discharges into the sea. Stratified ridges formed as a result of the influence of a quasi-stable terminus on the distribution of sedimentary facies along the grounding line. A field of push ridges formed along the grounding line of an unstable terminus that completely reworked the grounding-line deposits through glacitectonic deformation. Between 1860 A.D. and 1899 A.D. (39 years), 8.96×10 8 m 3 of sediment were deposited within the Muir Inlet morainal bank complex at an average annual sediment accumulation rate of 2.3×10 7 m 3 /a. This rate represents the annual sediment production capacity of the glacier when the Muir Inlet drainage basin is filled with glacial ice.
Total synthesis of the tetracyclic antimalarial alkaloid (±)-myrioneurinol.

The first total synthesis of the tetracyclic antimalarial Myrioneuron alkaloid (±)-myrioneurinol has been accomplished using three highly diastereoselective reactions as pivotal steps: 1) an intramolecular Michael addition of a benzyloxycarbonyl-protected lactam titanium enolate to an α,β-unsaturated ester for construction of the spirocyclic C5 quaternary center and the a/d rings, 2) a malonate anion conjugate addition to a transient nitrosoalkene to install the requisite functionality and configuration at the C7 position, and 3) an intramolecular sulfonyliminium aza-Sakurai reaction to form the b ring and the attendant C9/C10 configuration of the natural product.
Recent advances in sparsity-driven signal recovery

We briefly recall previous literature about the interaction between sparsity and /spl lscr/ /sup 1/ minimization. We then discuss /spl lscr/ /sup 1/ minimization in geometry separation, in compressed sensing, and in compressed sensing of separable signals.
Reliable early classification of time series

Early classification of time series is important in time-sensitive applications. An approach is presented for early classification using generative classifiers with the dual objectives of providing a class label as early as possible while guaranteeing with high probability that the early class matches the class that would be assigned to a longer time series. We give a specific algorithm for early quadratic discriminant analysis (QDA), and demonstrate that this classifier meets the requirement of reliable early classification.
Theory Pruning: Strategies to Reduce Our Dense Theoretical Landscape:

The current article presents a systematic approach to theory pruning (defined here as hypothesis specification and study design intended to bound and reduce theory). First, we argue that research that limits theory is underrepresented in the organizational sciences, erring overwhelmingly on the side of confirmatory null hypothesis testing. Second, we propose criteria for determining comparability, deciding when it is appropriate to test theories or parts of theories against one another. Third, we suggest hypotheses or questions for testing competing theories. Finally, we revisit the spirit of ‘‘strong inference.’’ We present reductionist strategies appropriate for the organizational sciences, which extend beyond traditional approaches of ‘‘critical’’ comparisons between whole theories. We conclude with a discussion of strong inference in organizational science and how theory pruning can help in that pursuit.
Hybrid rotor injection scheme for a doubly fed induction generator

Doubly fed induction generators used in wind energy applications require a source and power converter system to feed variable frequency ac voltage to its rotor. The paper presents a hybrid rotor injection system in which the rotor power can be drawn either from three-phase ac mains or a photo voltaic (PV) panel-battery combination. While drawing power from ac mains, the ac-dc converter used has a soft switching feature and also power factor correction. While drawing power from PV panel and battery, one of the MOSFET switches of the ac-dc converter will be used for boosting the PV panel output. The converter is simulated and the line currents show a low total harmonic distortion (THD). The results obtained on an experimental converter system are also presented.
Los alpes suizos en las sierras cordobesas. El Valle de Punilla y la historia sociocultural de la tuberculosis, 1870-1960.*

Antes de la llegada de los antibioticos en los anoscincuenta, la cura de reposo en los sanatorios ypensiones de las sierras cordobesas intentoorganizar las preocupaciones de vastos sectoresde la sociedad respecto de los enfermostuberculosos. Estas preocupaciones fuerontomando forma a todo lo largo de la primer mitaddel siglo XX, cuando la predica antituberculosadefinio mas claramente sus objetivos, alimento eltemor a la contagiosidad de la enfermedad eidentifico a los enfermos como peligrososportadores del mal. Descartando el recurso delencierro compulsivo, esta campana comenzo adesplegar iniciativas mucho mas sutiles dirigidasa controlar tanto como fuera posible la circulaciondel tuberculoso en la sociedad, intentandotransformarlo en un enfermo responsable,conciente y en gran medida autocontrolado. Estearticulo explora algunas dimensiones socioculturalesde esta alternativa de cura basada en elaire puro, la buena alimentacion y la vida reposada,una alternativa a la que accedieron pocos enfermostuberculosos pero tremendamente influyentetanto en la historia general de las sierras como enlas percepciones de la enfermedad modeladas porla sociedad y la cultura.
Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles

During skeletal muscle contraction, NO derived from neuronal nitric oxide synthase (nNOS) in skeletal muscle fibers or from endothelial cells (eNOS) may relax vascular smooth muscle contributing to...
Reaction Processes for Low Temperature (<150°C) Plasma Enhanced Deposition of Hydrogenated Amorphous Silicon Thin-Film Transistors on Transparent Plastic Substrates

This article presents mechanisms for low temperature ( 2 /Vs, respectively, with I ON /I OFF ratios > 106.
Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factor.

Background Glial cell line-derived neurotrophic factor (GDNF) is present in adult gut although its role in the mature enteric nervous system is not well defined. The aim of the present study was to examine the role of GDNF as neuromodulator of the ascending phase of the peristaltic reflex. Methods Colonic segments were prepared as flat sheets and placed in compartmented chambers so as to separate the sensory and motor limbs of the reflex. Ascending contraction was measured in the orad compartment and mucosal stroking stimuli (two to eight strokes) were applied in the caudad compartment. GDNF and substance P (SP) release were measured and the effects of GDNF and GDNF antibody on contraction and release were determined. Mice with reduced levels of GDNF (Gdnf+/−) and wild type littermates were also examined. Key Results GDNF was released in a stimulus-dependent manner into the orad motor but not caudad sensory compartment. Addition of GDNF to the orad motor but not caudad sensory compartment augmented ascending contraction and SP release. Conversely, addition of GDNF antibody to the orad motor but not caudad sensory compartment reduced ascending contraction and SP release. Similarly, the ascending contraction and SP release into the orad motor compartment was reduced in Gdnf+/− mice as compared to wild type littermates. Conclusions & Inferences The results suggest that endogenous GDNF is released during the ascending contraction component of the peristaltic reflex where it acts as a neuromodulator to augment SP release from motor neurons thereby augmenting contraction of circular muscle orad to the site of stimulation.
PRODUCT SELECTION AND BRAND INTERCHANGE: A THEORETICAL MODEL

AbstractOne of the contratemps within the pharmaceutical industry is the ongoing debate regarding generic drug substitution for brand-name pharmaceutical products. The Federal Government, consumer and elderly advocates, and generic product manufacturers have taken one side of the issue and research-intensive pharmaceutical manufacturers have taken the other.This paper presents two behavioral models of drug product selection which are consistent with most state's legal requirements of the pharmacist. These models are presented to solicit further confirmatory research into the process they describe and the impacts that result. Evidence is presented from a 1979-1980 study of Florida's product selection activity and its comparison with a 1977 similar study, just after the initiation of Florida's law.These models have been developed so that the various sides of t h i s important issue w i l l better understand the pharmacist's motivations and the impact of various stimuli on hidher decision-making process when...
Cooperative path planning for timing-critical missions

This paper presents a cooperative path planning approach for teams of vehicles operating under timing constraints. A cooperative control approach based on coordination variables and coordination functions is introduced and applied to cooperative timing problems. Three types of timing constraints are considered: simultaneous arrival, tight sequencing, and loose sequencing. Simulation results demonstrating the approach are presented.
Plenary Address 3: Heterogeneous Parallel Computing

Heterogeneous parallel computing (i.e., parallel computers where the processors are customized or tailored to efficiently execute specific.classes of algorithms) is the only practical way to solve many computationally intensive problems. In contrast to array computers constructed with identical general purpose processors, heterogeneous parallel computing achieves very high levels of throughput, small size, and low power. The improvement in the speed-size product is often in excess of two orders of magnitude. This talk reviews past endeavors in application specific processing (which can be viewed as the root of heterogeneous computing), current research in heterogeneous parallel computing, and offers the prediction that in the near future “system compilation” (analogous to “silicon compilation”) will greatly facilitate the development of heterogeneous parallel computers.
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on native cells. The voltage-gated proton channel Hv1 enables NOX function by compensating cellular loss of electrons with protons. Accordingly, we investigated whether NOX-mediated brain damage in stroke can be inhibited by suppression of Hv1. We found that mouse and human brain microglia, but not neurons or astrocytes, expressed large Hv1-mediated currents. Hv1 was required for NOX-dependent ROS generation in brain microglia in situ and in vivo. Mice lacking Hv1 were protected from NOX-mediated neuronal death and brain damage 24 h after stroke. These results indicate that Hv1-dependent ROS production is responsible for a substantial fraction of brain damage at early time points after ischemic stroke and provide a rationale for Hv1 as a therapeutic target for the treatment of ischemic stroke.
Advance Care Planning: The Dietitian's Role

THIS IS THE first article in a 2-part series, which is intended to promote an appreciation and advocacy of Advance Care Planning (ACP) for Registered Dietitian Nutritionists (RDNs) in nephrology practice. The first articlewill describe the utilization of palliative care and hospice care among end-stage renal disease (ESRD) patients. The second article in this series will describe the RDN’s role as a key advocate of the interdisciplinary team in the ESRD setting at this critical and sensitive stage of patient care. Elderly patients with ESRD often have significant comorbidities and other deficits that affect their quality of life. An increasing awareness of the burden and impact of ESRD on patients and families is stimulating the development of a framework for ACP in ESRD care. The goal of ACP is to encourage more open discussions involving the complex decisions that relate to the initiation and the withdrawal of dialysis; and the Renal Physicians Association (RPA) has produced valuable resources including guidelines and tools for addressing the complexities of end-of-life decision-making in ESRD patients.
An Alternative Display Could Lead to Earlier Diagnosis of Intracerebral Pathology with a Hemedex Flow Probe In Situ

Objective To report 2 cases of patients who had an ischemic stroke and an intracerebral hematoma after a superficial temporal artery-middle cerebral artery bypass with a thermal diffusion blood flow probe in situ and emphasize how a change in the way the data are presented could have led to an earlier diagnosis. Methods Both patients had flow probes within 2 cm of the graft site and were thus close enough to be representative of local or regional rather than global perfusion. Data smoothening was applied to the raw data that were available and displayed on the monitor. Both the smoothed plots and the raw plots were analyzed. Results Good clinical correlation was observed between the flow probe data and the clinical condition of both patients. This was more apparent when viewing the smoothed plots. Conclusions Although there was good clinical correlation, data displayed on the perfusion monitor can be incorrectly interpreted because the signal-to-noise ratio is small. We therefore suggest an alternative presentation of perfusion data for clinicians to recognize hypoperfusion and to take informed action before a stroke or hematoma is clinically manifest.
Photocatalytic Regeneration of Nicotinamide Cofactors by Quantum Dot–Enzyme Biohybrid Complexes

We report the characterization of biohybrid complexes of CdSe quantum dots and ferredoxin NADP+-reductase for photocatalytic regeneration of NADPH. Illumination with visible light led to reduction of NADP+ to NADPH, with an apparent kcat of 1400 h–1. Regeneration of NADPH was coupled to reduction of aldehydes to alcohols catalyzed by a NADPH-dependent alcohol dehydrogenase, with each NADPH molecule recycled an average of 7.5 times. The quantum yield both of NADPH and alcohol production were 5–6% for both products. Light-driven NADPH regeneration was also demonstrated in a multienzyme system, showing the capacity of QD-FNR complexes to drive continuous NADPH-dependent transformations.
Ischnochitonika lasalliana, New Genus, New Species (Copepoda), a Parasite of Tropical Western Atlantic Chitons (Polyplacophora: Ischnochitonidae)

ABSTRACT A copepod parasite, Ischnochitonika lasalliana, new genus, new species, is described from the polyplacophoran mollusks Ischnochiton striolatus (Gray, 1828) from Isla de Margarita, Venezuela, and Stenoplax boogi (Haddon, 1886) from southeast of Pensacola, Florida, in the northern Gulf of Mexico. The female, which resides in the chiton's branchial cavity, is characterized by a swollen, laterally elongate ectosoma and a bifurcated tubular endosoma that extends through the host's visceral cavity. Egg masses are attached to the lateral aspects of the ectosoma and are composed of grapelike clusters of variable size and egg number. The much smaller sexually dimorphic males exhibit 2 pairs of anterior processes. Multiple males characteristically are found with each female. Copepods have not been reported previously as parasites of chitons. Due to the lack of external morphological characters typical of many parasitic copepods, the phylogenetic position of Ischnochitonika lasalliana is uncertain.
A Review of “Crossing through Chueca: Lesbian Literary Culture in Queer Madrid”

Is there a queer identity in Spain today? Does literary culture reflect the enormous transformation lived in Spain during the last four decades? With the general growth of lesbian, gay, bisexual, t...
Impact Resistance of Automobile Tires

Abstract The construction and operation of a high speed plunger test machine to determine the impact energy required to produce failure of automobile tires are described. The equipment has been designed to operate over an energy range of 1500 to 15,000 in. lb at preselected velocities between 40 and 100 mph and at preselected temperatures between 75 and 300° F. These ranges are adequate to permit the testing of passenger tires over a range of conditions simulating those encountered in high speed driving. The test machine consists of a pneumatic gun for propelling the plunger at an inflated tire, mounted in a temperature controlled cabinet, and photoelectric devices for measuring plunger velocity. In a test the kinetic energy of the plunger is increased in increments, until failure occurs. The minimum kinetic energy required to cause failure of the tire fabric is taken as a measure of the carcass breaking energy. Data on rayon and nylon cord tires indicate that the breaking energy of a tire is dependent on...
The lack of gastric tissue fibrinolysis in hemorrhagic gastritis in the rat.

SummaryGastric mucosal fibrinolytic activator activity was measured in rats with aspirin or cold/restraint stress-induced hemorrhagic gastritis, compared to paired controls. No significant difference in FAA was found in the gastric mucosa of the experimental and control rats. It is unlikely that local gastric fibrinolysis plays a major role in the causing or maintaining hemorrhagic gastritis.
(11)C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease.

Abstract This longitudinal study sought to determine whether the 18 kDa translocator protein (TSPO), a marker of neuroinflammation, increases over time in Alzheimer's disease. Positron emission tomography imaging with the TSPO radioligand 11 C-PBR28 was performed at baseline and after a median follow-up of 2.7 years in 14 amyloid-positive patients and 8 amyloid-negative controls. Patients had a greater increase in TSPO binding than controls in inferior parietal lobule, precuneus, occipital cortex, hippocampus, entorhinal cortex, and combined middle and inferior temporal cortex. TSPO binding in temporoparietal regions increased from 3.9% to 6.3% per annum in patients, but ranged from −0.5% to 1% per annum in controls. The change in TSPO binding correlated with cognitive worsening on clinical dementia rating scale-sum of boxes and reduced cortical volume. The annual rate of increased TSPO binding in temporoparietal regions was about 5-fold higher in patients with clinical progression (n = 9) compared with those who did not progress (n = 5). TSPO may serve as a biomarker of Alzheimer's progression and response to anti-inflammatory therapies.
A Quick Method of Choosing Input Capacitors for CPU Switching Voltage Regulator Down(VRD) Circuit

A quick method of choosing right input capacitors for CPU step down CCM switching voltage regulator down(VRD) circuit is presented in this paper.And the importance of input capacitors is also analyzed,as well as its parameters and working principle.Then engineering application formulas to calculate input capacitors are deduced.With these formulas,engineers can get the right input capacitors solution for their specific DC-DC buck circuit in a very short time.
On Raising the Quality Minority University Students in Xinjiang

The development of Xinjiang is basically depending on the education of minority talents and their quality-raising.Due attention should be paid to the quality education of the minority university and college students,taking actions in raising the comprehensive quality of them.
The Essential Neo1 Protein from Budding Yeast Plays a Role in Establishing Aminophospholipid Asymmetry of the Plasma Membrane

Eukaryotic organisms typically express multiple type IV P-type ATPases (P4-ATPases), which establish plasma membrane asymmetry by flipping specific phospholipids from the exofacial to the cytosolic leaflet. Saccharomyces cerevisiae, for example, expresses five P4-ATPases, including Neo1, Drs2, Dnf1, Dnf2, and Dnf3. Neo1 is thought to be a phospholipid flippase, although there is currently no experimental evidence that Neo1 catalyzes this activity or helps establish membrane asymmetry. Here, we use temperature-conditional alleles (neo1ts) to test whether Neo1 deficiency leads to loss of plasma membrane asymmetry. Wild-type (WT) yeast normally restrict most of the phosphatidylserine (PS) and phosphatidylethanolamine (PE) to the inner cytosolic leaflet of the plasma membrane. However, the neo1-1ts and neo1-2ts mutants display a loss of PS and PE asymmetry at permissive growth temperatures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (duramycin) exposed in the extracellular leaflet. When shifted to a semi-permissive growth temperature, the neo1-1ts mutant became extremely hypersensitive to duramycin, although the sensitivity to papuamide A was unchanged, indicating preferential exposure of PE. This loss of asymmetry occurs despite the presence of other flippases that flip PS and/or PE. Even when overexpressed, Drs2 and Dnf1 were unable to correct the loss of asymmetry caused by neo1ts. However, modest overexpression of Neo1 weakly suppressed loss of membrane asymmetry caused by drs2Δ with a more significant correction of PE asymmetry than PS. These results indicate that Neo1 plays an important role in establishing PS and PE plasma membrane asymmetry in budding yeast.
Management of Penetrating Back Trauma

The best management plan for patients with stab wounds of the posterior abdomen who have no obvious indication for operation is a selective one. Repeated physical examination is the mainstay of treatment, as indicated by many authors. Other special studies, such as diagnostic peritoneal lavage, angiography, intravenous pyelography, and contrast computed tomographic scanning, are indicated on a case-by-case basis but as yet lack convincing justification for routine use.
Introduction, Special Issue: Feminist Legal Theory

Half a century after the beginning of the second wave, feminist legal theorists are still writing about many of the subjects they addressed early on: money, sex, reproduction, and jobs. What has changed is the way that they talk about these subjects. Specifically, these theorists now posit a more complex and nuanced conception of power. Recent scholarship recognizes the complexities of power in contemporary society, the ways in which these complexities entrench sex inequality, and the role that law can play in reducing inequality and increasing agency. The feminist legal theorists in this volume are emblematic of this effort. They carefully examine the relationship between gender, equality, and power across an array of realms: sex, reproduction, pleasure, work, money. In doing so they identify social, political, economic, developmental, and psychological and somatic forces, operating both internally and externally, that complicate the expression and constraint of power. Finally, they give sophisticated thought to the possibilities for legal interventions in light of these more complex notions of power.
Assessing the investigative needs of rural law enforcement

Although the topic of rural crime has received relatively little attention in traditional criminal justice research, the more specialized subtopic of rural criminal investigation has received even less. As criminological research and public attention begin to focus upon rural crime due to its rapid growth, rural police agencies will need to assess their investigative attitudes and resources in an effort to reduce accelerating crime rates. This paper surveyed the attitudes of 52 rural sheriffs in an effort to gather information necessary to assess needs and attitudes unique to the rural investigation.
Validation of DPYD variants DPYD*2A, I560S, and D949V as predictors of 5-fluorouracil (5-FU)-related toxicity in stage III colon cancer (CC) patients from adjuvant trial NCCTG N0147.

3510 Background: Prediction of 5-FU-related adverse events (5FU-AEs) continues to be problematic. Pharmacogenetic studies on the rate-limiting enzyme in 5-FU metabolism, dihydropyrimidine dehydroge...
Native resistance ofPeromyscus maniculatus toNematospiroides dubius infection

Because of its native resistance,Peromyscus maniculatus cannot be a natural host forNematospiroides dubius.
A study on the effectiveness of Vocational Training to Students with Disabilities- A case study from Kerala, India.

Abstract Human Resource Development can only be sustainable when it is equitable, inclusive and accessible for all. Persons with disabilities need therefore to be included at all stages of development processes. It becomes more critical for India, as its demographic dividend can only be realised with rapid creation of employment and opportunities for generating income. Improving employment prospects for the disabled will be critical for their development. According to UNDP report (2012), in India, the skills and potential of most people living with disabilities remain untapped, underutilized or under developed. Vocational training is one of the potential determinants of employment among People with differently abled. They should get proper vocational training after a full assessment of training needs and suitability, carried out by a multidisciplinary team of doctors, therapists, social workers, counsellors and other professionals. Once course is selected, these children need effective special training even within the inclusive education and it is the most important requirement in the process of their rehabilitation. Proper skill training should start from the initial vocational education itself. This paper aims to examine both the process of selection of courses and the effectiveness of skill training for differently abled students in initial vocational education of Kerala i.e., Vocational Higher Secondary Education (VHSE). The paper emphasises the need of occupational therapy in our school system. Training area should be selected according to the nature, type and extent of disability. The teachers should get special training in this area and their support is necessary for the child during the training process. Infrastructure requirements are still needed in most of the schools. Thus it is possible to skill this human resource pool to industry needs and thus can contribute the country’s economy. Conclusions and recommended actions are included in the paper.
Ouisconsin Eidos, Wisconsin Idea, and the Closure of Ideation

“Ouisconsin Eidos” names the becoming other of ideational thought, the digitalization of a logocentric thinking intimately allied with the history of phonetic writing, the book, the archive, the university, protocols of academic publishing—and Western colonialism. If ideation makes possible modern research and knowledge, its displacement may oscillate between violence and hope, ignorance and wisdom. Since ideation unfolds through phonetic writing, post-ideational thought-action entails engagement with emerging digital forms, habits, and infrastructures. The smart media genres formalized at UW-Madison’s DesignLab function as experiments mounted amidst times of intense battles over the forms and functions of knowledge and higher education. The logic of Ouisconsin Eidos encourages other site-specific engagements.
A note on fourth moment-based direction dependence measures when regression errors are non normal

ABSTRACTMeasures of direction dependence enable researchers to determine the directionality of linear effects in bivariate data. Existing fourth moment-based approaches assume that regression error...
The creation of opportunity is an opportunity to create: Entrepreneurship as an outlet for the legacy motive

Abstract As evidence has accumulated that entrepreneurs may pay a financial penalty for their career choice, researchers have struggled to explain the motivation that might lead individuals to pursue the creation of new firms, technologies, and opportunities. We introduce the desire to leave a legacy as both a common source of motivation for many entrepreneurs, and a source of variation, as entrepreneurs who wish to leave a legacy must decide what they would like to leave behind, and whom they wish to benefit from that act. We discuss the implications of the different kinds of legacies for entrepreneurs and their organizations, particularly at founding and exit, when the legacy motive is likely to be particularly salient.
Make the Best of What’s Around

As the editors wrote in the introduction, we are living in “dark times” in a time of war, of economic downturn, and contextually for this letter, at a time in which education continues to change and is abject to intense criticism. While they are correct in their assessment, they also acknowledge that it is more important than ever to uncover places of hope and inspiration—inspiration for ourselves and for those we hope to educate.
Biosynthesis of monoethylene glycol in Saccharomyces cerevisiae utilizing native glycolytic enzymes

Abstract Monoethylene glycol (MEG) is an important commodity chemical with applications in numerous industrial processes, primarily in the manufacture of polyethylene terephthalate (PET) polyester used in packaging applications. In the drive towards a sustainable chemical industry, bio-based production of MEG from renewable biomass has attracted growing interest. Recent attempts for bio-based MEG production have investigated metabolic network modifications in Escherichia coli, specifically rewiring the xylose assimilation pathways for the synthesis of MEG. In the present study, we examined the suitability of Saccharomyces cerevisiae, a preferred organism for industrial applications, as platform for MEG biosynthesis. Based on combined genetic, biochemical and fermentation studies, we report evidence for the existence of an endogenous biosynthetic route for MEG production from D -xylose in S. cerevisiae which consists of phosphofructokinase and fructose-bisphosphate aldolase, the two key enzymes in the glycolytic pathway. Further metabolic engineering and process optimization yielded a strain capable of producing up to 4.0 g/L MEG, which is the highest titer reported in yeast to-date.
Drop-in suicide prevention group decreases suicidal ideation among Veterans

This study examined the effectiveness of a weekly, drop-in therapy support group designed for Veterans identified at increased risk for suicide. Veterans were identified as at risk for suicide and ...
LncRNA Meg3 protects endothelial function by regulating the DNA damage response

The role of long non-coding RNAs (lncRNAs) in regulating endothelial function through the DNA damage response (DDR) remains poorly understood. In this study, we demonstrate that lncRNA maternally expressed gene 3 (Meg3) interacts with the RNA binding protein polypyrimidine tract binding protein 3 (PTBP3) to regulate gene expression and endothelial function through p53 signaling ─ a major coordinator of apoptosis and cell proliferation triggered by the DDR. Meg3 expression is induced in endothelial cells (ECs) upon p53 activation. Meg3 silencing induces DNA damage, activates p53 signaling, increases the expression of p53 target genes, promotes EC apoptosis, and inhibits EC proliferation. Mechanistically, Meg3 silencing reduces the interaction of p53 with Mdm2, induces p53 expression, and promotes the association of p53 with the promoters of a subset of p53 target genes. PTBP3 silencing recapitulates the effects of Meg3 deficiency on the expression of p53 target genes, EC apoptosis and proliferation. The Meg3-dependent association of PTBP3 with the promoters of p53 target genes suggests that Meg3 and PTBP3 restrain p53 activation. Our studies reveal a novel role of Meg3 and PTBP3 in regulating p53 signaling and endothelial function, which may serve as novel targets for therapies to restore endothelial homeostasis.
Nonfermentative Bacilli Associated with Man: III. Pathogenicity and Antibiotic Susceptibility

As it is now possible as well as practical to identify nearly all nonfermentative Gram-negative bacilli recovered from clinical material, 565 strains of these bacteria were studied in respect to four features: incidence, distribution, potential pathogenicity, and antibiotic susceptibility. Four species, previously known to be opportunistic pathogens, Pseudomonas aeruginosa, P. maltophilia, Acinetobacter anitratus (Herellea vaginicola) , and A. Iwoffi (Mima polymorpha) , were the most commonly encountered. P. pseudoalcaligenes and P. fluorescens were also frequently encountered. Seven species of questionable pathogenicity were less common; these were P. stutzeri, P. acidovorans, P. putida, P. alcaligenes, P. multivorans, P. diminuta , and Chromobacterium typhiflavum. Bordetella bronchiseptica and Xanthomonas species, occasionally encountered, appeared to be nonpathogenic for man. Three of the five species of Moraxella associated with man were encountered: M. nonliquefaciens, M. osloensis , and M. phenylpyrouvica . Only one strain of Alcaligenes faecalis , of doubtful pathogenicity, was found. Some strains of A. odorans were pathogenic. Most strains of flavobacteria were not clinically significant; none of these corresponded biochemically to King's Flavobacterium meningosepticum .
Enzymatically Degassed Surface-Initiated Atom Transfer Radical Polymerization with Real-Time Monitoring

Polymer brush coatings are frequently prepared by radical polymerization, a notoriously oxygen sensitive process. Glucose oxidase (GOx) can inexpensively enable radical polymerization in solution by enzymatically consuming oxygen as it oxidizes glucose. Here, we report the growth of polymeric brushes using GOx-assisted atom transfer radical polymerization (ATRP) from a surface while open to air. Specifically, we grew a set of biomedically relevant polymer brushes, including poly(oligo(ethylene glycol) methacrylate) (POEGMA), poly(2-dimethylaminoethyl methacrylate) (PDMAEMA), poly(sulfobetaine methacrylate) (PSBMA), and poly(2-(methylsulfinyl)ethyl acrylate (PMSEA). For each of these polymers, we monitored GOx-assisted and GOx-free ATRP reaction kinetics in real time using quartz crystal microbalance (QCM) and verified findings with localized surface plasmon resonance (LSPR). We modeled brush growth kinetics considering bimolecular termination. This model fit our data well ( r2 > 0.987 for all samples) and shows the addition of GOx increased effective kinetic chain lengths, propagation rates, and reproducibility. We tested the antifouling properties of the polymer brush coatings against human blood plasma and were surprised to find that coatings prepared with GOx repelled more plasma proteins in all cases than their GOx-free counterparts.
Human Capital Ecosystem Construction in an Emerging Rugby Market

The authors develop a theory of human capital ecosystems and argue that sport markets are human capital ecosystems. After analyzing the emerging U.S. rugby market, the authors demonstrate that leag...
Spillover Effect of Opioid Reduction Interventions From Adult to Pediatric Surgery.

Abstract Background Procedure-specific prescribing guidelines and trainee education have reduced opioid overprescribing in adult surgical patients, but tailored interventions do not yet exist for children. It is unknown what effect these adult interventions have had on postoperative opioid prescribing in children at the same institution, where trainees rotate across both adult and pediatric services. Materials and methods This retrospective study of patients ( Results There were 3371 patients preintervention and 2439 patients postintervention. After the intervention, fewer patients were prescribed opioids (ENT: 97% versus 93%, P Conclusions Opioid prescribing rates are decreasing, but adult interventions did not achieve reductions in pediatric opioid prescribing at the same institution. There was no concomitant rise in postoperative ED visits or opioid refills as prescribing declined, indicating that the risks of reducing opioid prescriptions may be minimal. Development of evidence-based, procedure-specific prescribing guidelines that specifically address pediatric patients are needed to effectively minimize opioid overprescribing in this population.
Case-Based ECG Analysis

As useful as it is to learn about ECGs from specific ECG characteristics, such as the differential diagnosis of ST segment elevation, the true value of the ECG (or any diagnostic tool) is how it is used for individual patient care. The ECG is most valuable with three specific patient presentations. First, it is one of the fundamental tools for evaluating the patient with ongoing chest pain. Specific ECG characteristics, for example, the presence of ST segment elevation, will guide the management strategy for a patient. Second, the ECG is important for evaluating the patient with complaints or physical examination findings of ongoing of arrhythmia. Specific arrhythmia abnormalities include bradycardia, tachycardia, and an irregular heartbeat. Finally, the ECG is valuable for identifying the presence of structural heart disease or possible etiologies for arrhythmias in patients with symptoms such as syncope, fatigue, or shortness of breath. In this chapter, cases will be used to illustrate how the ECG is used in each of these three patient specific situations.
Synthesis and integration of thin film solid state electrolytes for 3D Li-ion microbatteries

An essential element to realize lithium-ion microbatteries is an effective and conformal thin film solid state electrolyte over irregular or porous structures with specific composition and controlled elemental spatial distribution. Atomic layer deposition is a surface reaction based and non-line-of-sight technique that can rationally design an optimal electrolyte material, including high conductivity for lithium ions; adhesion to the substrate; uniformity over large area; thermal, mechanical, and electrical stability; and reproducibility required to integrate this deposition method into a manufacturing process. This review focuses on the current state-of-the-art development of a thin film solid state electrolyte, highlights the tunability of the electrical and electrochemical properties by controlling the composition and the microstructure of these materials, and discusses the future outlook in this technologically important area.
Effect of Geometrical and Multiple Image Interactions on Tunneling and I-V Characteristics of Infrared Point-Contact Detectors

In this paper we wish to report some recent theoretical results on the effect of the image and multiple image interactions on the tunneling and rectification characteristics of metallic cat-whisker diodes used in precision determinations of infrared laser frequencies [1-3]. The structure is an ultra fine metal tip (< 1 μm radius) in contact with a flat metal anode separated by a distance of the order of 10-40 A. It has been suggested that the diode configuration can be considered a MOM planar tunneling junction described by Simmons theory [1,4]. The authors have questioned the applicability of the Simmons MOM model, based upon planar geometry, to the cat-whisker diode configuration and refined the model, using somewhat different solid state mechanisms [5-7]. This new model includes a thermally enhanced field induced tunneling process to explain the nonlinearity of the devices and a new rectification mechanism, independent of material asymmetry, which takes into account explictly the geometrical shape of the electrodes [8-10]. That is, the actual curvature of the tip gives rise to a nonuniform electric field across the metal-vacuum-metal (MVM) or metal-oxide-metal junction. As a consequence of the nonuniform field distribution, there is a different tunneling barrier for forward and reverse bias which leads to rectification [9].
Effect of Secondary Tasks on Police Officer Cognitive Workload and Performance Under Normal and Pursuit Driving Situations.

ObjectiveThe objective of this study was to assess the effects of single and multiple secondary tasks on officers’ performance and cognitive workload under normal and pursuit driving conditions.Bac...