cssi/SciSciGPT-SciSciNet huggingface dataset:
Management of recurrent mechanical prosthetic tricuspid valve thrombosis in the perioperative period of noncardiac surgery: a case report.

Introduction: Mechanical valves in the tricuspid position may be prone to thrombosis with even brief lapses in anticoagulation. The management of patients with a history of recurrent mechanical tricuspid valve thrombosis who require noncardiac surgery is complex. Case presentation: A 43-year-old Pakistani woman with a mechanical tricuspid valve and a history of multiple episodes of mechanical valve thrombosis presented for noncardiac surgery. After her surgery she was found to have another episode of valve thrombosis and underwent a redo tricuspid valve replacement. Conclusion: This case brings up the important dilemma that exists when patients with a mechanical tricuspid valve and a history of recurrent valve thrombosis require noncardiac surgery.
Negotiating the Gray Lines: an ethnographic case study of organizational conflict between advertorials and news

This paper reports an ethnographic case study of how one newspaper organization undertook the redesign of its advertorial products. Examining the design and production of advertorials enables us to see and understand the moments when the values of the interpretive communities of advertorialists (advertising) and journalists are invoked. This case study examines the potential for internal conflict within a news organization as distinctly oppositional interests--advertising and news--seek to control a newspaper's symbolic goods.
The Critical Role of AKT2 in Hepatic Steatosis Induced by PTEN Loss

Insulin signaling in the liver leads to accumulation of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Deletion of the phosphatase Pten (phosphatase and tensin homologue deleted on chromosome 10) reduces PIP3 levels and leads to fatty liver development. The purpose of this study was to investigate the mechanisms underlying lipogenesis that result from PIP3 accumulation using liver Pten-deletion mice. To explore the role of AKT2, the major liver AKT isoform in steatosis induced by deletion of Pten, we created mice lacking both Pten and Akt2 in hepatocytes and compared the effect of deleting Akt2 and Pten in the double mutants to the Pten deletion mice alone. Hepatic lipid accumulation was significantly reduced in mice lacking both PTEN and AKT2, as compared with Pten mutant mice alone. This effect was due to the role of AKT2 in maintaining expression of genes involved in de novo lipogenesis. We showed that lipid accumulation in the double mutant hepatocytes was partially reversed by expression of constitutive active FOXO1, a transcription factor downstream of AKT not dependent on inhibition of atypical protein kinase C. In summary, this study delineated regulation of lipid metabolism by PI3K signaling pathway by showing that AKT mediates PIP3 accumulation (mimicked by PTEN loss) induced lipid deposition in the liver and provided an important molecular mechanism for insulin-regulated hepatic lipogenesis.
DYNAMICAL METEOROLOGY | Hydraulic Flow

This article is reproduced from the previous edition, volume 3, pp 966–967, © 2003, Elsevier Ltd.
Comparative analysis of MRI vs mammography in evaluation of size, number of lesions and nodal status of breast cancer

600 Background: Breast MRI is thought to be better in evaluating patients (pts) with BrCa. Our study was to compare MRI vs mam to predict leisons and LNS in BrCa. Methods: A retrospective study of ...
Distinguishing Protonation States of Histidine Ligands to the Oxidized Rieske Iron-Sulfur Cluster through (15) N Vibrational Frequency Shifts.

The Rieske [2Fe-2S] cluster is a vital component of many oxidoreductases, including mitochondrial cytochrome bc1; its chloroplast equivalent, cytochrome b6f; one class of dioxygenases; and arsenite oxidase. The Rieske cluster acts as an electron shuttle and its reduction is believed to couple with protonation of one of the cluster's His ligands. In cytochromes bc1 and b6f, for example, the Rieske cluster acts as the first electron acceptor in a modified Q cycle. The protonation states of the cluster's His ligands determine its ability to accept a proton and possibly an electron through a hydrogen bond to the electron carrier, ubiquinol. Experimental determination of the protonation states of a Rieske cluster's two His ligands by NMR spectroscopy is difficult, due to the close proximity of the two paramagnetic iron atoms of the cluster. Therefore, this work reports density functional calculations and proposes that difference vibrational spectroscopy with (15) N isotopic substitution may be used to assign the protonation states of the His ligands of the oxidized Rieske [2Fe-2S] complex.
Phenomenological theory of low voltage electroporation: Electric field calculations

In common electroporators, cells can be transfected with foreign genes by applying a 150−700 V pulse on the cell suspension. Because of Joule heating, the cell survival rate is 10−20% in these elecroporators. In a recently developed electroporator, termed the low-voltage electroporator (LVEP), cells are partially embedded in the pores of a micropore filter. In LVEP, cells can be transfected by applying 25 V or less under normal physiological conditions at room temperature. The large increase in current density in the filter pores, produced by the reduction of current shunt pathways around each embedded cell, amplifies 1000-fold the local electric field across the filter and results in a high-enough transmembrane voltage for cell electroporation. The Joule heat generated in the filter pore is quickly dissipated toward the bulk solution on each side of the filter, and thus cell survival in the low-voltage electroporator is very high, about 98%, while the transfection efficiency for embedded cells is above 9...
Is use of oil-field brine as a dust-abating agent really benign? Tracing the source and flowpath of contamination by oil brine in a shallow phreatic aquifer

In Ohio, 1985 H.R. Bill 501 authorizes the local authorities to issue permits to use oil-field brine surface spreading as a dust and ice control agent. Such permits are usually given without any necessary hydrogeological expertise as to the potential impact on the shallow aquifers, particularly if the brine spreading occurs in a recharge area. One such case occurred recently in the southwestern suburb of the City of Wooster, OH, USA, where a group of home owners were seeking judicial relief when their water wells began yielding salty water as a result of brine spreading on a nearby large open storage area for oil and gas well drilling supplies. The defendant, owner of the storage yard, acted in accordance with the permit issued by the local authorities. Yet, decentralized decision making and an increased emphasis on local and citizen involvement have created a gap between science and society. The local authorities were not required by law to condition the issuance of the permit on an analysis of the potential environmental impact. The decision to issue that permit was made purely on non-scientific grounds. Therefore, the residents had no choice but to embark on a costly process of proving the damages, causation, and liability in court of law. During the protracted, 6-year long conflict, an extensive hydrogeological and hydrochemical data set (including stable isotopes’ analyses along with the complete chemical analyses of major and minor constituents) was amassed at a great cost to both sides. The following article presents the hydrogeological and hydrochemical interpretation of this data set. In addition, the case illustrates a glaring deficiency in the Ohio, 1985 H.R. Bill 501, and one pitfall in the “politically correct” philosophy of delegating decision-making process entirely to the non-professional local authorities.
The Road to Hell: Neutralization of Killing in War

ABSTRACTWe explore how societies convince citizens to “go to hell,” where they kill strangers and risk their own lives. Our premise is that killing is difficult for most, regardless of context and widely considered a form of extreme deviance. Using Sykes and Matza’s techniques of neutralization, we show how this aversion to killing is neutralized by placing individuals in organized—both macro-level bureaucratic and micro-level small primary groups—to justify killing. Consequently, the neutralization of mass killing illustrates the role of power in defining deviance, and the failure of neutralizations may sometimes explain Post-Traumatic Stress Disorder.
Intra-abdominal homologous heart transplantation.

SummaryA technique of homologous heart transplantation is described which permits study of the multiple aspects of cardiac function and rejection. Some preliminary results are described. Further utilization of this study model is indicated.
Ecodesign for cities and suburbs

Ecodesign for Cities and Suburbs is the work of two practitioners turned academics. Jonathan Barnett, Emeritus Professor of Practice at the University of Pennsylvania, has practised internationally...
Coimmunoprecipitation of proteins from yeast.

This protocol outlines a procedure for testing whether two proteins interact. A target protein will be immunoprecipitated using an antibody that recognizes it (or a tagged version of the protein). The immunoprecipitated material will be separated by SDS-PAGE and analyzed by Western blotting to assess the presence of a candidate interacting protein(s).
Penetrating cardiac trauma at an urban trauma center : A 22-year perspective

This is a report of a 22-year experience with penetrating cardiac trauma at a single urban Level I trauma center. We conducted a retrospective chart review supplemented by computerized patient log. Comparisons of mortality between Period 1 (1975-1985; 113 patients) and Period 2 (1986-1996; 79 patients) were by X 2 or Fisher's exact tests. Statistical significance was defined as P ≤ 0.05. From 1975 to 1996, 192 patients (mean age, 32 years; 88% male) with penetrating cardiac stab wounds (68%) or gunshot wounds (32%) were treated. The most common initial clinical presentation was cardiac tamponade, and most patients (54%) were hypotensive (systolic blood pressure 30-90 mm Hg). The most common initial intervention in the emergency center was tube thoracostomy. The use of pericardiocentesis as a diagnostic and therapeutic modality in the emergency center virtually disappeared in Period 2, as compared with Period 1. Since 1994, surgeon-performed cardiac ultrasound has been performed and has correctly diagnosed hemopericardium in 12 patients (100% survival). The overall mortality for all patients during the 22-year study interval was 25 per cent and was not significantly different between Period 1 (27%) and Period 2 (22%). The mortality associated with gunshot wounds was increased compared with that of stab wounds. Similarly, mortality for patients who arrested in the emergency center was increased compared with those patients who did not arrest. We conclude: 1) cardiac tamponade is the most common presentation in patients with cardiac wounds; 2) pericardiocentesis in the emergency center has essentially disappeared; 3) surgeon-performed ultrasound of the pericardium should improve survival of future patients who are normotensive or mildly hypotensive; 4) over the last 11 years, there has been a substantial decrease in mortality in patients with stab wounds and a statistically significant decrease in arrested patients; and 5) overall mortality for penetrating cardiac trauma has not changed during the 22-year interval.
Methodological Stance: The Marshallian Structure of the General Theory

Ever since Hicks’s (1937) pioneering interpretation of the General Theory, traditional Keynesian macroeconomics has been expressed in terms of a vision of interconnected sets of aggregated markets. Thus it has become commonplace for economists to speak of “the” markets for goods, labor, money and bonds, and of the simultaneous equilibrium solution of them considered as a system, when discussing various theoretical or applied macroeconomic issues. In fact, a case can be made that in the postwar era this became the basic meta-theory of macroeconomics and that it is Walrasian in origin and outlook (Weintraub, 1979). It is also true that a textual basis for the interconnectedness of the decisions of consumers, investors and asset holders is clearly present in the General Theory of 1936. Since Walrasian conceptions and mathematical treatments of economic theory were rapidly gaining ground at just the juncture at which Keynes’s book was published, it is not surprising that many young, mathematically trained interpreters “naturally” cast its central message in the form of simultaneous equilibrium equations in the spirit of Walras (Young, 1987; Laidler 1999, Chapters 11 and 12). But this interpretation, so widely accepted to the profession now, is not so natural an interpretation from the alternative perspective of looking backwards from the General Theory in 1936.
The effects of heat treatment on 7075 Al cold spray deposits

Abstract High-pressure cold spray was used to deposit 7075 aluminum powder onto 7075-T6 substrates. We investigated the effects of post deposition heat treatments on the microstructure and mechanical properties of the deposits. For this purpose, both low-temperature and high-temperature treatments were carried out on specimens excised from the deposits. Microstructures of the as-deposited and heat treated samples were characterized via different microscopy techniques and mechanical properties were evaluated by microtensile and hardness tests. The results were then correlated with the observed microstructures in different conditions. The strength and ductility of the cold sprayed 7075 deposits increased after both low- and high-temperature treatments, which resulted in precipitation of strengthening phases and increased inter-particle bonding. Because of a change in bonding mechanism, heat treatment at high temperature yielded markedly greater ductility than all other conditions. Diffusion and microstructural sintering at the particle-particle interfaces were proposed to cause the change in bonding mechanism from mechanical interlocking to metallurgical bonding and lead to the ductile characteristics of these samples. The understanding gained from this research should lead to optimization of and pre- and post-processing treatments for cold spray deposits.
High Performance Electrocatalytic Reaction of Hydrogen and Oxygen on Ruthenium Nanoclusters.

The development of catalytic materials for the hydrogen oxidation, hydrogen evolution, oxygen reduction or oxygen evolution reactions with high reaction rates and low overpotentials are key goals for the development of renewable energy. We report here Ru(0) nanoclusters supported on nitrogen-doped graphene as high-performance multifunctional catalysts for the hydrogen evolution reaction (HER) and oxygen reduction reaction (ORR), showing activities similar to that of commercial Pt/C in alkaline solution. For HER performance in alkaline media, sample Ru/NG-750 reaches 10 mA cm–2 at an overpotential of 8 mV with a Tafel slope of 30 mV dec–1. The high HER performance in alkaline solution is advantageous because most catalysts for ORR and oxygen evolution reaction (OER) also prefer alkaline solution environment whereas degrade in acidic electrolytes. For ORR performance, Ru/NG effectively catalyzes the conversion of O2 into OH– via a 4e process at a current density comparable to that of Pt/C. The unusual catal...
Enhancing Skills, Effecting Change: Evaluating an Intervention for Students with Below-proficient Information Literacy Skills

An intervention was developed for first-year community college students with below proficient information literacy skills. This presentation focuses on the development of the intervention and the evaluation of the intervention through pre- and post-intervention surveys, and in-depth interviews with intervention participants. A ete concue une seance d’intervention s’adressant aux etudiants de premiere annee d’un college communautaire ayant des lacunes en maitrise de l’information. Cette communication porte sur le developpement et l’evaluation de cette intervention au moyen de questionnaires pre et post intervention et d’entrevues en profondeur avec les participants. ***Full paper in the Canadian Journal of Information and Library Science ***
Variations of anatomy on MRI of the first extensor compartment of the wrist and association with DeQuervain tenosynovitis.

To study anatomical variations on MRI of the first extensor compartment of the wrist in DeQuervain tenosynovitis (DQT). A retrospective search for DQT patients yielded 47 subjects (51 ± 15 years, 36 female, 11 male). The age-matched control group (normal first extensor compartment) was 49 ± 15 years (29 female, 18 male). Two independent readers reviewed: the number of abductor pollicis longus (APL) tendon slips, tendon sheath septations (compartmentalization), and APL and EPB cross-sectional area (CSA) at the radial styloid. A tendon slip was defined as a discrete structure for ≥5 contiguous slices with its own insertion. The distribution of APL tendon slips was different for the DQT and control groups (Reader 1/Reader 2: P = 0.0001 and 0.001). The most common arrangement for both groups was two APL tendon slips. One tendon slip was less common (P = 0.03 and 0.1) and compartmentalization was more common (P = 0.003; < 0.0001) for the DQT group than the control group. There was no difference in tendon slip insertions on one or multiple bones (P = 0.1; 0.7). APL and EPB compartment CSAs were also higher for the DQT group (combined first extensor compartment area: 21.3 ± 7.6 mm2; 21.0 ± 7.1) than the control group (17.2 ± 3.8; 17.1 ± 3.9) (P = 0.002; 0.002). We found a statistically significantly increased proportion of supernumerary tendon slips and compartmentalization of the first extensor compartment in patients with DQT and greater CSA of the first extensor compartment at the radial styloid, consistent with previous anatomical, surgical, and ultrasound studies.
Moments and Metagenres: Coordinating Complex, Multigenre Narratives

Professional and technical communication increasingly involves developing narratives that traverse multiple genres, media formats, and publishing venues. In marketing and advertising, brand stories unfold across Web sites, ad campaigns, and social media properties. A fundamental challenge in such work is multigenre coordination, leading to a key question: How do professionals manage complex ecologies of genres, media content, and interactions in ways that build and sustain narrative coherence and audience engagement? Reporting findings from a study of transmedia writers, this article argues that metageneric texts may emerge as important coordinative resources for planning, developing, and tracking uptakes within multigenre narratives. It thus contributes to professional and technical communication by describing a widening gap in scholarly approaches to metagenre; arguing for empirical examinations of metageneric constructs in tangible, flexible texts that serve situated needs in given activity systems; an...
The habenula as a novel link between the homeostatic and hedonic pathways in cancer-associated weight loss: a pilot study.

Background Little is known about the brain mechanisms underlying cancer-associated weight loss (C-WL) in humans despite this condition negatively affecting their quality of life and survival. We tested the hypothesis that patients with C-WL have abnormal connectivity in homeostatic and hedonic brain pathways together with altered brain activity during food reward. Methods In 12 patients with cancer and 12 healthy controls, resting-state functional connectivity (RSFC, resting brain activity observed through changes in blood flow in the brain which creates a blood oxygen level-dependent signal that can be measured using functional magnetic resonance imaging) was used to compare three brain regions hypothesized to play a role in C-WL: the hypothalamus (homeostatic), the nucleus accumbens (hedonic), and the habenula (an important regulator of reward). In addition, the brain reward response to juice was studied. Participants included 12 patients with histological diagnosis of incurable cancer (solid tumours), a European Cooperative Oncology Group performance status of 0-2, and a ≥5% involuntary body weight loss from pre-illness over the previous 6 months and 12 non-cancer controls matched for age, sex, and race. RSFC between the hypothalamus, nucleus accumbens, and habenula and brain striatum activity as measured by functional MRI during juice reward delivery events were the main outcome measures. Results After adjusting for BMI and compared with matched controls, patients with C-WL were found to have reduced RSFC between the habenula and hypothalamus (P = 0.04) and between the habenula and nucleus accumbens (P = 0.014). Patients with C-WL also had reduced juice reward responses in the striatum compared with controls. Conclusions In patients with C-WL, reduced connectivity between both homeostatic and hedonic brain regions and the habenula and reduced juice reward were observed. Further research is needed to establish the relevance of the habenula and striatum in C-WL.
Stability of the 1144 phase in iron pnictides

A series of iron arsenides (e.g., ${\text{CaRbFe}}_{4}{\text{As}}_{4}, {\text{SrCsFe}}_{4}{\text{As}}_{4}$) have been discovered recently, and have provoked a rise in superconductor searches in a different phase, known as the 1144 phase. For the presence of various chemical substitutions, it is believed that more 1144 compounds remain to be discovered. In this work, we perform general model analysis as well as scenario calculation on a basis of density functional theory to investigate phase stability in a variety of compounds. We predict that the 1144-type phase could be stabilized in ${\text{EuKFe}}_{4}{\text{As}}_{4}, {\text{EuRbFe}}_{4}{\text{As}}_{4}, {\text{EuCsFe}}_{4}{\text{As}}_{4}, {\text{CaCsFe}}_{4}{\text{P}}_{4}, {\text{SrCsFe}}_{4}{\text{P}}_{4}, {\text{BaCsFe}}_{4}{\text{P}}_{4}, {\text{InCaFe}}_{4}{\text{As}}_{4}, {\text{InSrFe}}_{4}{\text{As}}_{4}$, etc. Remarkably, it involves rare earths, trivalence elements (e.g., indium) and iron phosphides, which greatly expands the range of its existence and suggests a promising prospect for experimental synthesis. In addition, we find that the formation of many random doping compounds (e.g., ${\text{Ba}}_{0.5}{\text{Cs}}_{0.5}{\text{Fe}}_{2}{\text{As}}_{2}, {\text{Ba}}_{0.5}{\text{Rb}}_{0.5}{\text{Fe}}_{2}{\text{As}}_{2}$) is driven by entropy and could be annealed to a 1144-type phase. Eventually, we plot a phase diagram about two structural factors $\mathrm{\ensuremath{\Delta}}a$ and $\mathrm{\ensuremath{\Delta}}c$, giving a bird's-eye view of stability of various 1144 compounds.
Measurements of 3 1 P Concentrations Produced by Neutron Transmutation Doping of Silicon

The absolute concentrations of 3 1P, produced by the irradiations of float zone silicon samples in the Texas A§M University Research Reactor, have been measured to an accuracy of ± 10%. The neutron fluence was varied from 1016 to 1018n/cm2, which corresponded to 3 1P concentrations in the 1012 to 1014 atoms/cm3 range. The results are based on measurements of the absolute activities of 3 1Si by detection of 1.266 MeV gamma rays. Secondary standards of Fe were required for the larger neutron fluences. The 3 lp concentrations were compared to the concentrations of electrically active P following 850°C anneals for 1 hour. These concentrations were determined in the same samples from temperature-dependent Hall effect measurements at Hughes Research Laboratories. The two results agree to within experimental error, thus confirming that transmuted P in the 1012 to 1014 atoms/cm3 range is completely electrically active following 850°C, 1 hour anneals of float zone silicon. In addition, a corrected value for the gamma abundance of31Si was established to be 5.6 x 10-4 ± 10%.
Molecular Biology of Burkitt Lymphoma

Burkitt lymphoma is characterized by very well-defined chromosomal translocations involving the MYC gene and one of the immunoglobulin loci. While these translocations have been recognized for more than 30 years, our understanding of the cause and consequences of these genetic rearrangements has been evolving slowly, as has the identification of other molecular alterations found in Burkitt lymphoma. This is partially due to the complexities of MYC transcriptional and posttranscriptional regulation, and Myc protein function. It is now thought that Myc is involved in the coordination of many essential cellular pathways that are in general related to cell growth, but range from genetic stability to metabolism. The altered expression of Myc is coupled in Burkitt lymphomas with genetic events that protect the cells from apoptotic death, which may be cellular or viral in origin. This review focuses on our current understanding of the molecular complexity of Burkitt lymphoma with respect to the etiopathogenesis of this disease.
The Unitary Executive in the Modern Era, 1945-2004

Since the impeachment of President Clinton, there has been renewed debate over whether Congress can create institutions such as special counsels and independent agencies that restrict the president's control over the administration of the law. Initially, debate centered on whether the Constitution rejected the executive by committee used by the Articles of Confederation in favor of a unitary executive, in which all administrative authority is centralized in the president. More recently, the debate has focused on historical practices. Some scholars suggest that independent agencies and special counsels are such established features of the constitutional landscape that any argument in favor of a unitary executive is foreclosed by established practice. Others, led by Bruce Ackerman, claim that the New Deal represented a constitutional moment that ratified big changes in the distribution of power within the federal government. Still others argue that the added policymaking role of the modern administrative state means Congress ought to be able to impose greater limits on presidential control over the execution of the law. To date, however, a full assessment of the historical record has yet to appear. This Article is part of a larger project offering a comprehensive chronicle of the battles between the president and Congress over control of the administration of federal law. It reviews the period between 1945 and 2004, paying particular attention to the Clinton impeachment and the lapse of the independent-counsel statute. The record shows that presidents from Harry S. Truman through George W. Bush consistently defended the unitariness of the executive branch, vitiating any claim that a custom of allowing congressional incursions on the unitary executive has emerged. In fact, the episodes discussed herein eloquently illustrate both the legal and the normative arguments supporting the unitary executive.
On Third Sound Amplification by Stimulated Condensation

We describe the process by which condensing 4 He vapor atoms are expected to contribute coherently to the macroscopic superfluid motion of a third sound resonance. This phenomenon is similar to the experimentally observed thickening of a film in the fixed velocity state of a persistent current, though with an interesting and subtle difference. As before, the condensing atoms contribute to the kinetic energy of the macroscopic state by the coherent normal-to-superfluid conversion. In the present case, however, the macroscopic state is an oscillatory third sound mode. This allows the energy to remain in the third sound mode even if superfluid is removed by film flow in order to keep the film thickness constant. Thus, a continuous process of third sound amplification by stimulated condensation should accompany a condensing vapor flux under the right conditions.
Securitized banking, procyclical bank leverage, and financial instability

Abstract This paper provides a theoretical explanation of procyclical leverage of the broker-dealer sector and examines its macroeconomic consequences within the context of the securitized banking system characterized by loan securitization and collateralized short-term borrowing. First, from a model of repo transaction, it is shown that a broker–dealer (repo borrower)'s optimal leverage is positively related to asset prices. The main mechanism underlying this relation is a movement of repo rate, which reflects counter-party risks and collateral value risks repo lenders are facing. Second, based on this result, I develop a macroeconomic model with a securitized banking system characterized by procyclical bank leverage and identify conditions under which the model exhibits a limit cycle behavior. A vulnerability of the repo market to asset price fluctuations leads to procyclical bank leverage, which aggravates asset price cycles driven by the supply-led credit expansion and collapse. It is also found that as the procyclicality of bank leverage becomes stronger the financial cycles also get more intense and severe.
Therapeutic challenges in the treatment of systemic inflammatory disease in pregnancy.

BackgroundGranulomatosis with polyangiitis and Behcet’s disease can occur during pregnancy and may be treated by ophthalmologists, rheumatologists, and obstetricians. We hypothesized that specialty...
Boundaries, Gatekeeping, and Oppression Within Science Education Research

I employ an arts-based method to express my concerns and frustrations about the field of science education research. I draw primarily upon experiences I had as a graduate student, when the stifling pressure to conform nearly ended my academic career before it began. Through poetry, I hope to raise questions, surface issues, and highlight voices. In so doing, I also invite others in to create space for their own concerns, tensions, and wonderings about the field. Throughout, I raise questions about how we engage in social justice work in light of the gatekeeping represented in the poem.
Square wave voltammetry for real time analysis of minor metal ion concentrations in molten salt reactor fuel

Abstract Molten salt mixtures containing LiCl-KCl-UCl3-CeCl3 were used as surrogates for molten salt reactor fuel in a study of electrochemical concentration analysis. Current responses to low concentration CeCl3 (0.5 wt% Ce) in molten eutectic LiCl-KCl with high concentration UCl3 (5 and 10 wt% U) were measured using cyclic voltammetry (CV) and square wave voltammetry (SWV). CV peaks associated with CeCl3 were impossible to quantify because of dominant reducing current contribution from UCl3. SWV results featured peaks from UCl4, UCl3, and CeCl3 with minimal baseline interference. A potential hold at −1.5 V for 100 s was effective at cleaning the working electrode in between each SWV scan, which enabled generating reproducible (with ±1.10% average error) peak current results for CeCl3 over a period of 2 h. The peak current density for CeCl3 increased by 8.3% from doubling the U concentration from 5 to 10 wt%, thus indicating that this method is promising for measuring minor metal ion concentrations in molten salt reactor fuel with high U concentrations.
Should We Call You Mom and Dad? Caregiver Preferences and Pediatric Physician and Nurse Manner in Greetings

OBJECTIVES: In this study, we evaluated whether caregivers preferred to be called “Mom” and “Dad” or by name in the inpatient pediatric setting and how often caregivers reported that residents, attending physicians, and nurses greeted them as they preferred. METHODS: We measured caregivers’ greeting preferences and perceptions of how residents, attending physicians, and nurses greeted them by surveying caregivers on 1 unit at a large urban children’s hospital from October 2017 to April 2018. The 27-item survey consisted of multiple choice, Likert scale, and demographic measures. A member of the study team enrolled caregivers at the patient’s bedside to complete the written survey anonymously. RESULTS: A total of 114 caregivers completed the survey (51% of 223 enrolled caregivers); 63% (95% confidence interval [CI] 53%–74%) of mothers and 57% (95% CI 36%–77%) of fathers preferred to be greeted as Mom and Dad, respectively; the rest preferred greetings by name. Caregiver preferences did not significantly vary on the basis of relationship to the child (mother or father), age, race, or education level (P > .05). Caregivers reported that 48% (95% CI 35%–62%) of residents, 43% (95% CI 29%–57%) of attending physicians, and 63% (95% CI 49%–75%) of nurses always or usually addressed them as they preferred. CONCLUSIONS: Approximately half of mothers and fathers preferred to be called Mom and Dad, respectively, whereas the rest preferred to be greeted by name. Caregiver preferences did not differ on the basis of demographics. Caregivers reported that residents, attending physicians, and nurses were inconsistent in following their greeting preferences.
Stock Forecasting Using M-Band Wavelet-Based SVR and RNN-LSTMs Models

The task of predicting future stock values has always been one that is heavily desired albeit very difficult. This difficulty arises from stocks with non-stationary behavior, and without any explicit form. Hence, predictions are best made through analysis of financial stock data. To handle big data sets, current convention involves the use of the Moving Average. However, by utilizing the Wavelet Transform in place of the Moving Average to denoise stock signals, financial data can be smoothened and more accurately broken down. This newly transformed, denoised, and more stable stock data can be followed up by non-parametric statistical methods, such as Support Vector Regression (SVR) and Recurrent Neural Network (RNN) based Long Short-Term Memory (LSTM) networks to predict future stock prices. Through the implementation of these methods, one is left with a more accurate stock forecast, and in turn, increasing profits.
Effect of Inspiratory Muscle Training with Elastic Taping on Forced vital capacity and Sway Area in Stroke Patients

Purpose: The purpose of this study was to evaluate the forced vital capacity and sway area of respiratory muscles taping with threshold inspiratory muscles training for 1 week. Methods: Nineteen stroke patients were divided into two groups: experimental group (respiratory muscles taping with threshold inspira tory muscles training, n=10) and control group (threshold inspiratory muscles training, n=9). Forced vital capacity tests were performed using a spirometer. The instrument records the forced vital capacity (FVC). COP excursion test was performed using Zebris. The instru ment records the sway area. All tests were measured before and after intervention. Results: The experimental group and control group showed significant increase in FVC (p 0.05). Conclusion: Threshold inspiratory muscles training is an effective intervention for improving FVC. Threshold inspiratory muscles training with respiratory taping is an effective intervention for improving FVC and sway area. Threshold inspiratory muscles training with respira tory taping can improve balance ability.
Genotype-guided hydralazine therapy

Background Despite its approval in 1953, hydralazine hydrochloride continues to be used in the management of resistant hypertension, a condition frequently managed by nephrologists and other clinicians. Hydralazine hydrochloride undergoes metabolism by the N-acetyltransferase 2 (NAT2) enzyme. NAT2 is highly polymorphic as approximately 50% of the general population are slow acetylators. In this review, we first evaluate the link between NAT2 genotype and phenotype. We then assess the evidence available for genotype-guided therapy of hydralazine, specifically addressing associations of NAT2 acetylator status with hydralazine pharmacokinetics, antihypertensive efficacy, and toxicity. Summary There is a critical need to use hydralazine in some patients with resistant hypertension. Available evidence supports a significant link between genotype and NAT2 enzyme activity as 29 studies were identified with an overall concordance between genotype and phenotype of 92%. The literature also supports an association between acetylator status and hydralazine concentration, as fourteen of fifteen identified studies revealed significant relationships with a consistent direction of effect. Although fewer studies are available to directly link acetylator status with hydralazine antihypertensive efficacy, the evidence from this smaller set of studies is significant in 7 of 9 studies identified. Finally, 5 studies were identified which support the association of acetylator status with hydralazine-induced lupus. Clinicians should maintain vigilance when prescribing maximum doses of hydralazine. Key Messages: NAT2 slow acetylator status predicts increased hydralazine levels, which may lead to increased efficacy and adverse effects. Caution should be exercised in slow acetylators with total daily hydralazine doses of 200 mg or more. Fast acetylators are at risk for inefficacy at lower doses of hydralazine. With appropriate guidance on the usage of NAT2 genotype, clinicians can adopt a personalized approach to hydralazine dosing and prescription, enabling more efficient and safe treatment of resistant hypertension.
[Epidemiological characteristics and measures of prevention and control of imported COVID-19 cases in early phase in Shanghai]

Objective: To analyze the epidemiological characteristics of imported COVID-19 cases in early phase in Shanghai, introduce measures and provide reference for prevention and control of imported COVID-19 cases. Methods: Data of imported COVID-19 cases in Shanghai reported as of 30 March, 2020 were obtained from National Notifiable Disease Report System of China CDC and field epidemiological investigation reports by CDCs in Shanghai. The information about measures of prevention and control was collected from official websites and platforms of the governments. Data cleaning and statistical analysis were performed with softwares of EpiData 3.1, Excel 2019 and SAS 9.4. Results: A total of 171 imported COVID-19 cases had been reported as of 30 March, 2020 in Shanghai, including 170 confirmed cases and 1 asymptomatic infection case. Among them, cases of Chinese nationality accounted for 71.3% (122/171) and cases of foreign nationality accounted for 28.7% (49/171). The median age of the cases was 23 years (P(25), P(75): 18, 35 years), and the male to female ratio of the cases was 1.3∶1. Students accounted for 56.6% (97/171). About 45.6% (78/171) of the cases fell ill before arriving in Shanghai. The cases with mild or common clinical manifestation accounted for 96.5% (165/171) and no significant difference in clinical type was observed between overseas Chinese cases and foreign cases. The epidemic curve by diagnosis date reached peak on March 24, and the number of the cases gradually declined due to the closed-loop management process of joint port prevention and control mechanism. The 171 imported COVID-19 cases were mainly from 24 countries and regions, including the United Kingdom (64 cases, 37.3%), the United States (32 cases, 18.6%), France (19 cases, 11.0%) and Italy (16 cases, 9.4%). About 40.4% of the cases (69/171) planned to continue travelling to 21 other provinces and municipalities in China. Customs quarantine and community observation/detection points identified 43.9% (75/171) cases and 31.0% (53/171) cases, respectively. Conclusions: The imported COVID-19 cases in early phase in Shanghai were mainly young population and students accounted for high proportion. The imported risk of COVID-19 was consistent with the severity of the epidemic in foreign countries. The closed-loop management model of the joint port prevention and control mechanism plays an important role in the identification and management of the imported COVID-19 cases.
Obstetrician-gynecologist perceptions and utilization of prescription drug monitoring programs: A survey study.

ABSTRACT Query of Prescription Drug Monitoring Programs (PDMPs) is recommended before prescribing opioids by the US Centers for Disease Control and Prevention, to inform clinical practice and aid diversion prevention. Many states mandate prescriber PDMP use; however, little is known about PDMP perception of utility and use among Obstetricians-Gynecologists (OB/GYN), who are the primary provider for most women during pregnancy.This study examined OB/GYN perceptions and utilization of their state PDMP.Survey items were developed by expert consensus. A voluntary anonymous survey was emailed to a random sample of 5000 OB/GYNs (adjusted participants n = 1470, minus unread/refusals). Responses were stratified by state policy environment, where response frequency distributions were compared for OB/GYNs practicing in states with mandatory vs voluntary PDMP query.Adjusted response rate was 27% (n = 397). Most OB/GYNs (78%) were registered with their PDMP. The majority agreed that "…mandating physician use of the PDMP was a good idea" (51.4% mandatory state vs 58.3% voluntary state). Respondents in mandatory states reported that the primary purpose of the PDMP was "to allow the physician to verify medications that the patient is being prescribed" less frequently than those in voluntary states (38.3% vs 52.8%). Several report speaking with patients about controlled substance prescriptions after viewing PDMP reports (27.8% in mandatory vs 26.3% in voluntary states). In qualitative responses, reported frustration with PDMPs was evident.OB/GYNs are diverse in their perceptions regarding the utility and purpose of PDMPs. Tailored education is needed regarding clinical utility of PDMPs for OB/GYN practice.
Multi-scale convolutional neural networks for the prediction of human-virus protein interactions

Allowing the prediction of human-virus protein-protein interactions (PPI), our algorithm is based on a Siamese Convolutional Neural Network architecture (CNN), accounting for pre-acquired protein evolutionary profiles (i e PSSM) as input In combinations with a multilayer perceptron, we evaluate our model on a variety of human-virus PPI datasets and compare its results with traditional machine learning frameworks, a deep learning architecture and several other human-virus PPI prediction methods, showing superior performance Furthermore, we propose two transfer learning methods, allowing the reliable prediction of interactions in cross-viral settings, where we train our system with PPIs in a source human-virus domain and predict interactions in a target human-virus domain Notable, we observed that our transfer learning approaches allowed the reliable prediction of PPIs in relatively less investigated human-virus domains, such as Dengue, Zika and SARS-CoV-2 © 2021 by SCITEPRESS - Science and Technology Publications, Lda
Diversity of structures and functions of oxo-bridged non-heme diiron proteins

Oxo-bridged diiron proteins are a distinct class of non-heme iron proteins. Their active sites are composed of two irons that are coordinated by amino acid side chains, and a bridging oxygen that interacts with each iron. These proteins are members of the ferritin superfamily and share the structural feature of a four α-helix bundle that provides the residues that coordinate the irons. The different proteins also display a wide range of structures and functions. A prototype of this family is hemerythrin, which functions as an oxygen transporter. Several other hemerythrin-like proteins have been described with a diversity of functions including oxygen and iron sensing, and catalytic activities. Rubrerythrins react with hydrogen peroxide and rubrerythrin-like proteins possess a rubredoxin domain, in addition to the oxo-bridged diiron center. Other redox enzymes with oxo-bridged irons include flavodiiron proteins that act as O2 or NO reductases, ribonucleotide reductase and methane monooxygenase. Ferritins have an oxo-bridged diiron in the ferroxidase center of the protein, which plays a role in the iron storage function of these proteins. There are also bacterial ferritins that exhibit catalytic activities. The structures and functions of this broad class of oxo-bridged diiron proteins are described and compared in this review.
Connecting Corresponding Identities across Communities

One of the most interesting challenges in the area of social computing and social media analysis is the so-called community analysis. A well known barrier in cross-community (multiple website) analysis is the disconnectedness of these websites. In this paper, our aim is to provide evidence on the existence of a mapping among identities across multiple communities, providing a method for connecting these websites. Our studies have shown that simple, yet effective approaches, which leverage social media’s collective patterns can be utilized to find such a mapping. The employed methods successfully reveal this mapping with 66% accuracy.
Deuterium-labeled Steroids for Study in Humans I. ESTROGEN PRODUCTION RATES IN NORMAL PREGNANCY

Deuterium-labeled 1,3,5(10)-estratriene-3,17 β-diol was used for the estimation of estrogen production rates during normal pregnancy. The results for three patients are concordant with the available reports in the literature. Isotope dilution data were obtained by gas chromatography-mass spectrometry. The steroids were monitored by conventional scanning of the molecular weight range at 20 e.v. or 70 e.v. and at selected m/e values at 20 e.v. by the use of an accelerating voltage alternator.
A scalable decoder architecture for linear congruential LDPC codes

Maximal length linear congruential sequence (MLLCS) based LDPC codes have the advantage that the LDPC code graph can be generated at the receiver without having to explicity store the graph. Hence, these codes are advantageous when the same hardware needs to be used for different sets of rates and lengths. In this paper, we reveal an inherent structure in these codes that facilitates parallel implementation of the decoding algorithm. Based on this, we present an architecture for the MLLCS-LDPC decoder that facilitates parallel scalable implementation and joint code-decoder design.
The Pediatric Pneumogram: A New Method for Detecting and Quantitating Apnea in Infants

A clinically useful diagnostic method has been developed for detecting and quantitating periods of apnea in pediatric patients. This procedure, called the pediatric pneumogram, permits the continuous recording on magnetic tape, for periods of up to 13 hours, of the respiratory pattern of infants utilizing an impedance technique. This test has been employed successfully in a variety of infants to evaluate respiratory activity and has permitted the objective documentation of apneic and cyanotic episodes, as well as an assessment of the effectiveness of therapy.