cssi/SciSciGPT-SciSciNet huggingface dataset:
Two populations of guinea pig erythrocyte-rosetting cells in the cat: evidence for their T-helper function in mitogen-induced synthesis of Ig and interleukin-2.

Abstract Studies in our laboratory have shown that T-helper (T-H) and T-suppressor (T-S) cells in cat peripheral blood leukocytes (PBL) rosette with guinea pig (GP) and gerbil (G) erythrocytes (E), respectively. Removal of GE-rosetting cells leads to an enhanced (two- to threefold) synthesis of Ig in a pokeweed mitogen (PWM)-driven system as measured by plaque-forming cells (PFC) to protein A-coated sheep RBC, while depletion of GPE-rosetting cells yields a PFC response only 10–15% of the control. Surprisingly, removal of both GE- and GPE-rosetting cells gave a response equivalent to 40–100% of the control PBL. Analysis of the mixed GE/GPE rosette depleted cultures revealed the reappearance of GPE- but not GE-rosetting cells, reaching maximum values within 12–18 hr after in vitro culture. Cultures of control PBL and those following the mixed rosette depletion showed two populations of GPE-rosetting cells; the GPE-1 cells, present on Day 0 before culture, and the GPE-2 cells, those appearing on Day 1. Addition of cycloheximide prevented development of the GPE receptor while colchicine and mitomycin C were without effect. The development of PFC after the mixed GE/GPE rosette depletion was interpreted as being due to the GPE-2 cells functioning as T-H cells in the absence of any T-S (GE-rosetting) cells. This thesis was supported by showing a marked decrease in the PWM-induced Ig response when both the GPE-1 and GPE-2 populations were removed on Day 1. Additional evidence for functional T-H cells in the GPE-rosetting population was obtained by analyzing interleukin-2 (IL-2) production. Removal of the GPE-rosetting cells (GPE-1 and/or GPE-2) from PBL led to a marked decrease in Con A-induced IL-2 synthesis while removal of the GE-rosetting cells yielded a normal or slightly greater than normal response.
A Sex Difference in Mental Rotation in Infants: Convergent Evidence

Quinn and Liben (2008) reported a sex difference on a mental rotation task in which 3- to 4-month-olds were familiarized with a shape in different rotations and then tested with a novel rotation of the familiar shape and its mirror image. As a group, males but not females showed a significant preference for the mirror image, a pattern paralleled at the individual level (with most males but less than half the females showing the preference). Experiment 1 examined a possible explanation for this performance difference, namely, that females were more sensitive to the angular differences in the familiarized shape. Three- to 4-month-olds were given a discrimination task involving familiarization with a shape at a given rotation and preference testing with the shape in the familiarized versus a novel rotation. Females and males preferred the novel rotation, with no sex difference observed. This finding did not provide support for the suggestion that the sex difference in mental rotation is explained by differential sensitivity to angular rotation. Experiment 2 revealed that the sex difference in mental rotation is observed in 6- to 7-month-olds and 9- to 10-month-olds, suggesting that a sex difference in mental rotation is present at multiple ages during infancy.
Targeting adenovirus to CD80 and CD86 receptors increases gene transfer efficiency to malignant glioma cells.

Object Gene therapy protocols for malignant gliomas utilize adenoviral vectors that rely almost exclusively on the adenovirus serotype 5 (Ad5) backbone. The authors have previously shown that chimeric vectors that bind to the Ad3 receptor, or CD46, increase the transduction efficiency of malignant brain tumors. In light of the debate regarding the efficacy of CD46 compared with CD80/CD86 in binding Ad3 virions, the authors now examine the expression and transduction efficiency of Ad5/3 chimeras that bind via CD80/CD86. Methods The authors first analyzed CD80/CD86 expression in glioma cell lines. They then used three replication-defective vectors containing a luciferase reporter gene: Ad5/3 (containing the tail and shaft domain of Ad5 and the knob domain of Ad3); Ad3/5 (containing the tail of Ad5, shaft of Ad3, and knob of Ad5); and Ad3/3 (containing the tail of Ad5, shaft of Ad3, and knob of Ad3). These vectors were analyzed both in vitro and in vivo against malignant glioma cells. To examine further the ...
Intravenous azathioprine in severe ulcerative colitis: a pilot study.

Abstract OBJECTIVE: Azathioprine use in acute ulcerative colitis has been limited by its perceived long onset of action. The aim of this study was to determine the safety and clinical effect of an i.v. loading dose of azathioprine in the setting of severe steroid refractory ulcerative colitis. METHODS: Nine hospitalized patients with severe steroid refractory ulcerative colitis were enrolled. Patients 1–3 received 20 mg/kg i.v. azathioprine over 36 h. Patients 4–6 received 40 mg/kg i.v. azathioprine over 36 h. Patients 7–9 received 40 mg/kg i.v. azathioprine as three 8-h infusions over 3 days. Clinical remission was defined as steroid withdrawal and an Ulcerative Colitis Disease Activity Index score of 0. The Inflammatory Bowel Disease Questionnaire was obtained at each visit. White blood cell concentrations and erthyrocyte concentrations of 6-thioguanine were obtained. RESULTS: Five of nine patients (56%) had a response and avoided colectomy. Three of nine patients (33%) met the definition for clinical remission. Response was seen within 4 wk. The mean 6-thioguanine concentration for those five patients at 12 wk after infusion was 148.2 pmol/8 × 10 8 . Two patients had transient leukopenia and one had transient hepatotoxicity. CONCLUSIONS: Intravenous azathioprine appears to be safe and of clinical benefit in inducing response and avoiding colectomy in severe steroid refractory ulcerative colitis. Data from an i.v. azathioprine trial in Crohn’s disease suggests oral dosing alone may obtain the same results. The role of oral dosing alone in severe ulcerative colitis and the role of azathioprine metabolite levels in monitoring efficacy should be investigated further.
Colonoscopy in radiation colitis

Colonoscopy in 13 patients with stenosis or hemorrhage after radiation therapy is correlated with clinical and radiographic features. The authors found colonoscopy helpful in delineating the diagnosis and in guiding treatment.
Data handling strategies for high throughput pyrosequencers

Background New high throughput pyrosequencers such as the 454 Life Sciences GS 20 are capable of massively parallelizing DNA sequencing providing an unprecedented rate of output data as well as potentially reducing costs. However, these new pyrosequencers bear a different error profile and provide shorter reads than those of a more traditional Sanger sequencer. These facts pose new challenges regarding how the data are handled and analyzed, in addition, the steep increase in the sequencers throughput calls for much computation power at a low cost.
Iron Loading into Ferritin by an Intracellular Ferroxidase

Abstract An intracellular, membrane-bound enzyme exhibiting both p -phenylenediamine oxidase activity and ferrous iron oxidase activity was isolated with the plasma membrane fraction of horse heart and studied for its ability to load iron into ferritin. The ferroxidase activity of the tissue oxidase was stimulated approximately twofold by horse spleen apoferritin, and the iron was loaded into ferritin. The loading of iron into ferritin by the tissue oxidase was inhibited by anti-horse serum ceruloplasmin antibody. The stoichiometry of iron oxidation and oxygen consumption during iron loading into ferritin by the tissue-derived oxidase and serum ceruloplasmin were 3.6 ± 0.2 and 3.9 ± 0.2, respectively. These data provide evidence that an enzyme analogous to ceruloplasmin is present on the plasma membrane of horse heart and that this ferroxidase is capable of catalyzing the loading of iron into ferritin. The implications of these data on the present models for the uptake and storage of iron by cells are discussed.
Optimization of grating depth and layer thicknesses for DFB lasers

The novel concept of K-stabilizing layer is reported for the first time. The coupling coefficient (K) which determines the characteristics of distributed feedback laser diodes (DFB LDs) has been controlled by optimizing the grating depth and layer thicknesses. The coupling coefficient is less dependent on the variations of grating depth and layer thicknesses if an optimized K- stabilizing layer (lower index material like InP) is inserted between the active layer and the guide layer. The controllability of the coupling coefficient has been demonstrated by the standard deviation of the lasing wavelength and the threshold current across a wafer, 0.74 nm and 2.67 mA, respectively.
Safety-net hospitals more likely than other hospitals to fare poorly under Medicare's value-based purchasing.

Medicare’s value-based purchasing (VBP) program potentially puts safety-net hospitals at a financial disadvantage compared to other hospitals. In 2014, the second year of the program, patient mortality measures were added to the VBP program’s algorithm for assigning penalties and rewards. We examined whether the inclusion of mortality measures in the second year of the program had a disproportionate impact on safety-net hospitals nationally. We found that safety-net hospitals were more likely than other hospitals to be penalized under the VBP program as a result of their poorer performance on process and patient experience scores. In 2014, 63 percent of safety-net hospitals versus 51 percent of all other sample hospitals received payment rate reductions under the program. However, safety-net hospitals’ performance on mortality measures was comparable to that of other hospitals, with an average VBP survival score of thirty-two versus thirty-one among other hospitals. Although safety-net hospitals are still...
Efficient formation of au nanoparticles and Fe 2 O 3 /Au@SiO 2 nanocomposite: Effect of functional alkoxysilanes

Glycidoxypropyltrimethoxysilane (GPTMS) was employed, for the first time, as a new sonochemical promoter for the synthesis of gold nanoparticles (NPs) as well as γ-Fe 2 O 3 /Au@SiO 2 nanocomposites. In either case, GPTMS shows higher efficiency at reduction rate of Au(III) than conventional radial scavengers (alcohols), which is likely attributed to a cascade to generate 4-folds higher amount of alcoholic products during hydrolysis. Gold NPs were successfully attached to the surface of γ-Fe 2 O 3 cores during the process of nucleation and growth of gold NPs, forming gold islands. The ratio of γ-Fe 2 O 3 /Au was estimated to be 4.0, which is ∼3-folds higher than that obtained from a two-step conjugation procedure of γ-Fe 2 O 3 /thiol-silane/Au. The effect of other frequently used silane reagents was also investigated. A relatively lower ratio of Au/γ-Fe 2 O 3 was obtained by using tetraethyl orthosilicate or PEG-silane, while such reduction reaction was remarkably quenched by amine- or thiol-silane reagents. The mechanism of quenching was depicted.
Permeability of dense (homogeneous) cellulose acetate membranes to methane, carbon dioxide, and their mixtures at elevated pressures

Mean permeability coefficients for CH 4 and CO 2 (P CH4 and P CO2 ) in cellulose acetate (CA, DS = 2.45) were determined at 35°C (95°F) and at pressures up to about 54 atm (800 psia). The measurements were made with pure CH 4 and CO 2 as well as with CH 4 /CO 2 mixtures containing 9.7, 24.0, and 46.1 mol % CO 2 . In the measurements with the pure gases, P CH4 was found to decrease with increasing pressure, as expected from the dual-mode sorption model. By contrast, P CO2 passes through a minimum and then increases with increasing pressure, probably due to the plasticization (swelling) of CA by CO 2 . The values of P CH4 and P CO2 determined with the mixtures containing 9.7 and 24.0 mol % CO 2 decrease with increasing total pressure ; this behavior is adequately described by the extended dual-mode sorption model for mixtures. By contrast, the values of P CH4 and P CO2 obtained with the mixture containing 46.1 mol % CO 2 pass through a minimum and then increase as the total pressure is raised, probably also due to the plasticization of CA by CO 2 . The CO 2 /CH 4 selectivity (=P CO2 /P CH4 ) of the CA membranes decreases with increasing total pressure and, at constant pressure, decreases with increasing CO 2 concentration in the feed mixture. The effects of exposing the CA membranes to high-pressure CO 2 prior to the permeability measurements (conditioning effects) on P CH4 and P CO2 have also been studied.
Response to ‘Interspinous bursitis is common in polymyalgia rheumatica, but is not associated with spinal pain’

In a recent contribution to this journal,Camellino and colleagues [1] reported that asymptomatic inflammation of the interspinous bursas is a common occurrence in patients with polymyalgia rheumatica. Thus, they confirm the findings of three other studies which found florid inflammation (which was felt to be symptomatic) at these sites between the spinous processes of adjacent vertebrae. Why would this be so when bursitis at more accessible locations is not recognized as a part of this syndrome? One possible explanation might be found in the proximity of each interspinous bursa to its adjacent ligamentum flavum [2]. If the fundamental process is an auto-immune response to elastic tissue, then this most elastic of all anatomical structures would be an appropriate target and a 'sympathetic effusion' might be expected in adjacent tissues such as the interspinous bursas. A similar situation could explain the characteristic synovitis of large joints in polymyalgia. There, scanning techniques demonstrate an unequivocal inflammatory cause for the joint pain and stiffness, but the effusions are small, synovial fluid findings are unimpressive, and the synovitis is not destructive. This, too, could represent an immune response to aging elastic tissue of the joint capsule with the synovitis being secondary. Possible elastic antigenicity is not a new idea in giant cell arteritis [3]. Localization of inflammatory cells around the internal elastic laminas of temporal artery biopsies was prominent from the first recognition of this entity and remains so today [4]. Apparent elastic fragments within giant cells, immunoglobulin deposits adjacent to the internal elastic lamina, proliferative responses of lymphocytes to arterial tissue in vitro, and a striking response of mononuclear cells to elastin peptides all lend support to this idea, although none of these findings have been replicated convincingly [5]. Polymyalgia rheumatica can be excruciating, giant cell arteritis can be lethal, and both conditions respond dramatically to appropriate therapy. Yet their diagnosis can be difficult, and their common link has not been found. Confirmation of elastic antigenicity would provide much-needed understanding of the basic pathophysiology and could thereby facilitate both diagnosis and management. Does not someone want to take another look at the possibility that these findings and concepts may be held together with an elastic band?
Changes in Reproductive Traits Associated with Selection for Packed Erythrocyte Volume in Japanese Quail

Abstract During the separation of lines for high and low packed erythrocyte volume (PCV) of Japanese quail fed Fe, Cu adequate or Fe, Cu deficient diets, differences in egg production rate, fertility and hatchability developed but there were no changes noted in body weight. Lowered egg production appeared to be associated with selection for lowered PCV, but was not a direct effect of PCV level. Concomitant changes in fertility and hatchability were noted under both the Fe-Cu adequate and Fe-Cu deficient dietary environments. A decreased fertility and hatchability of low PCV lines compared to their respective high lines was observed. Reciprocal crosses of the high and low PCV lines indicated heterosis for body weight and hatchability, and apparent paternal effect for body weight and an apparent maternal effect for hatchability.
Chronic abdominal pain and upper gastrointestinal bleeding due to duodenal perforation caused by migrated inferior vena cava filter: A case report

The authors describe an unusual case of a 41-year-old man presenting with chronic abdominal pain and gastrointestinal bleeding caused by a migrated inferior vena cava filter eroding into the duodenum.
Curved MEMS resonators yield infrasonic resonant frequencies on single-chip in simulation study

This paper is motivated by the challenge to develop mechanical resonators with fundamental resonant frequencies in the infrasonic range 1-20 Hz that fit onto a single-chip module. In this paper, we present preliminary findings based on finite element modeling (FEM) analysis of designs prepared for fabrication based on SUMMiT VTM surface micromachining technology using curve-shaped beams clamped at both ends. Circular shapes considered are a flat-horseshoe shape (thickness is transverse to plane of substrate) and a split-ring shape (width is transverse to plane of substrate). For the FEM simulation study, we considered a single-chip module space size of 6mm diameter and resonators with 1 μm beam thickness. Designs are considered with and without added mass. We find that an order of magnitude reduction in the 1st mode resonant frequency is achievable by curving beams into a space of fixed size. The simulation results show that infrasonic resonant frequencies 2-20 Hz are achievable by curve-shaped resonators with “added mass” with 1 μm beam thickness for single-chip 6mm-diameter size.
Jean-Paul Sartre and the philosophy of négritude: Race, self, and society

In this article, Jean-Paul Sartre’s relationship to the negritude movement and black intellectuals in Paris between the 1940s and the 1960s is examined in sociological and historical context. Sartre’s version of negritude, developed in his 1948 treatise “Orphee noir” prefacing Leopold Senghor’s collection of African and Malagasy poetry, is analyzed in terms of its role in shaping the discourses and debates surrounding negritude and the relationship of black intellectuals to the rest of French society. Sartre’s phenomenological theories of race, juxtaposing dominant and subaltern ideologies, are contrasted with his dialectic of negritude. The antinegritude movement of the late 1960s is also considered with reference to Sartre’s theories and inspiration. During this period, the relationship that Sartre established with Martinican intellectual and revolutionary Frantz Fanon helped to place Sartre into prominence as an activist and a theorist of decolonization and Third World politics. Sartre’s theories of race, self, and society were integral to both his early and later works and warrant review as approaches to the sociology of culture and sources of reflection for contemporary postcolonial studies.
Evolution of salt structures during burial of salt sheets on the slope, northern Gulf of Mexico

Abstract Shallow buried, allochthonous salt sheets are the dominant type of salt structure along the lower slope of the northern Gulf of Mexico. Trailing (landward) margins of the sheets are buried during continental margin progradation, while their leading edges advance basinward under thin cover. During burial a series of daughter structures, including stocks, massifs and remnant structures, evolved as the sheet was segmented by extension and differential loading. During extension, fault-bound basins on the upper surface of the sheet initiated the growth of salt rollers. Some rollers matured into stocks and massifs as sediment accumulated rapidly in circular salt withdrawal basins that were localized over the initial fault-bound basins. Lateral extension is a key mechanism in initiating salt structural evolution; however, simple vertical subsidence of sediments is the primary displacement mechanism. Where the salt is completely displaced, a salt weld discontinuity identifies its former stratigraphic position. A variety of structures in the eastern Green Canyon Area have been identified overlying a Neogene salt weld, including remnant salt structures, mature stocks, massifs and sedimentary structures such as turtle structure anticlines.
Misorientation texture development during grain growth. Part II: Theory

A critical event model for the evolution of number- and area-weighted misorientation distribution functions (MDFs) during grain growth is proposed. Predictions from the model are compared to number- and area-weighted MDFs measured in Monte Carlo simulations with anisotropic interfacial properties and several initial orientation distributions, as well as a dense polycrystalline magnesia sample. The steady-state equation of our model appears to be a good fit to all data. The relation between the grain boundary energy and the normalized average boundary area is discussed in the context of triple junction dynamics.
Rate adaptation and base station reconfiguration for battery efficient video download

With increasing usage of mobile devices to watch mobile video, the battery consumption of mobile devices will be dominated by video delivery and playback. In this paper, we develop battery efficient video delivery techniques that vary video transmission rate dynamically depending on battery and buffer levels of the mobile device, the channel conditions experienced, and video quality requirements while maximizing battery life and ensuring user experience. The proposed dynamic video rate adaptation techniques enable the base station to adapt the Multi Input Multi Output (MIMO) transceiver configurations to reduce battery current required by MIMO components on the mobile device. The proposed techniques also make the base station stop video transmission opportunistically, thereby eliminating the battery load imposed by the mobile MIMO components. Experiments conducted under various network conditions for various video download profiles show that more than 50% improvement in battery lifetime is possible in comparison to conventional video download techniques not aware of battery.
Characterization of 20 highly variable tetranucleotide microsatellite loci for bull trout (Salvelinus confluentus) and cross-amplification in other Salvelinus species

We describe the isolation and development of 20 polymorphic tetranucleotide microsatellite loci for bull trout ( Salvelinus confluentus ). In a sample of 76 fish, we observed between four and 23 alleles per locus. These loci show greater levels of genetic diversity than other loci previously examined in bull trout. Seventeen of these loci were also polymorphic in at least one of the following species: Salvelinus alpinus, Salvelinus malma, Salvelinus namaycush and Salvelinus fontinalis . These loci will aid in our understanding of the molecular ecology of bull trout and other char.
Response of Deutectomized Chicks to Dietary Fat Supplementation

Abstract THE EGG YOLK contains approximately 6-7 grams of fat, most of which is intact in the yolk sac in the abdominal cavity of the chick at hatching. Three experiments were conducted to determine the effect of removal of the yolk sac (deutectomy) from the chick at hatching time, upon the chick’s growth response t o dietary corn oil supplementation, and upon the level of liver lipids. EXPERIMENTAL Athens-Canadian randombred chicks were used in this work. Fertile eggs were obtained from the flock at the Southern Regional Poultry Breeding Project and incubated. The chicks that were deutectomized were operated on within 12 hours after hatching. This was accomplished by a 1/8 to 1/4 inch incision at the umbilical site, through which the intact yolk sac and its contents were teased. The connecting cord was cauterized and one suture used to close the incision. The basal diet used in these studies was …
Traveling-wave amplifiers with prescribed frequency response

Microwave transistor amplifier combinations that have controlled frequency response over a specified bandwidth were designed. Theoretical analysis of such an amplifier with an arbitrary number of sections is presented. The response of the amplifier is controlled by tapering the frequency selectivity or Q of each section of the amplifier. To verify the theory, a three-section amplifier with maximally flat time delay response was designed, constructed, and evaluated. Existing traveling-wave amplifiers were modeled as lossy transmission lines. Although the amplifiers were relatively broadband, a prescribed frequency response was not achieved, and each transistor did not receive an equal portion of the signal power. Resistive elements were required for impedance matching at the input and output. The design seeks to improve on previous techniques by trading bandwidth for controlled gain. By making the transmission line that connects the amplifier sections nonuniform, the frequency response was controlled over the design bandwidth. The designs can easily be implemented using familiar components. >
Clinical Implications of Current Developments in Genitourinary Pathology

Context.—Several developments in genitourinary pathology are likely to change our understanding and management of some genitourinary cancers considerably. Objective.—To review 5 stories in genitour...
THetA: inferring intra-tumor heterogeneity from high-throughput DNA sequencing data

Tumor samples are typically heterogeneous, containing admixture by normal, non-cancerous cells and one or more subpopulations of cancerous cells. Whole-genome sequencing of a tumor sample yields reads from this mixture, but does not directly reveal the cell of origin for each read. We introduce THetA (Tumor Heterogeneity Analysis), an algorithm that infers the most likely collection of genomes and their proportions in a sample, for the case where copy number aberrations distinguish subpopulations. THetA successfully estimates normal admixture and recovers clonal and subclonal copy number aberrations in real and simulated sequencing data. THetA is available at http://compbio.cs.brown.edu/software/
Toward understanding soft faults in high performance cluster networks

Fault management in high performance cluster networks has been focused on the notion of hard faults (i.e., link or node failures). Network degradations that negatively impact performance but do not result in failures often go unnoticed. In this paper, we classify such degradations as soft faults. In addition, we identify consistent performance as an important requirement in cluster networks. Using this service requirement, we describe a comprehensive strategy for cluster fault management.
Preservation of Accessory Pudendal Arteries During Radical Retropubic Prostatectomy: Surgical Technique and Results

Abstract Introduction Our institution previously described a surgical technique for preservation of accessory pudendal arteries at radical retropubic prostatectomy. Since then, we have expanded our experience. We now report our refinements in the surgical technique, illustrated with video, and the influence of accessory artery preservation on the recovery of sexual function after radical retropubic prostatectomy (RRP). Technical considerations Between 1987 and 2003, 2399 potent men underwent RRP. Of the 2399 men, 84 (4%) were identified with accessory pudendal arteries. Of the 84 men, 52, who underwent bilateral nerve-sparing surgery, were available for evaluation. We identified a control population, without accessory pudendal arteries, who were matched for age, stage, and neurovascular bundle status. Potency was defined as the ability to achieve unassisted intercourse with or without the use of sildenafil. In a Cox proportional hazards model, the effect of artery preservation increased the likelihood of potency more than twofold (relative risk 2.65; 95% confidence interval 1.11 to 6.32; P = 0.028). Kaplan-Meier analysis showed a significantly shorter median time to regain potency among those with artery preservation, 6 versus 12 months ( P = 0.020). Conclusions Preservation of accessory pudendal arteries may favorably influence the recovery of sexual function and interval to recovery after RRP.
Novel Therapeutic Approaches in Regenerative Medicine—Adult Tissue-Derived Very Small Embryonic-like Stem Cells and Harnessing Paracrine Signals of Adult Stem Cells

The regenerative medicine is searching for proper stem cells that could be employed for therapy to regenerate damaged solid organs (e.g., heart, Brain, or liver). It is striking that, for a variety of adult tissue-derived cells currently employed in experimental animal and clinical models (e.g., bone marrow or mobilized peripheral blood-derived CD34+ or CD133+ stem cells, mesenchymal stem cells), the observed final outcomes are often similar. This fact and the lack of convincing documentation for significant donor-recipient chimerism in organs (e.g., heart, liver, brain) in most of the patients treated with adult stem cells indicates that a mechanism other than transdifferentiation of stem cells infused systemically into peripheral blood or injected directly into damaged organs may play an important role in those cases where an obvious beneficial effect of stem cell therapy is observed. In this review, we will discuss the potential contribution of rare pluripotent/multipotent stem cells present in cell preparations (e.g., bone marrow, umbilical cord blood, mobilized peripheral blood) as well as a paracrine role of growth factors, cytokines, chemokines, bioactive lipids, and microvesicles (MVs) released from adult cells employed as cellular therapeutics in regenerative medicine.
Design and implementation of high performance dynamic 64-bit parallel adder with enhanced testability

This paper presents a fast, low power, binary carry look-ahead 64-bit dynamic parallel adder architecture for a high frequency microprocessor. The adder core is composed of several basic building blocks and feedback reset chain blocks implemented in self-resetting CMOS (SRCMOS) circuits. All circuits are design with enhanced testability. A new tool, SPA (SRCMOS Pulse Analyzer) is developed for dynamic and static checks. The nominal propagation delay and power dissipation of the adder are measured to be 1.5 ns (at 22 C with Vdd=2.5 V) and 300 mW. The adder core size is 1.6 mm/spl times/0.275 mm. The process that the design is based upon in a 0.5 /spl mu/m IBM CMOS5X technology with 0.25 /spl mu/m effective channel length and 5 layers of metal. The circuit techniques are ready to be migrated to sub-nanosecond microprocessor design.
MOS Translinear Principle for All Inversion Levels

In this brief, we derive a translinear principle for alternating loops of saturated MOS transistors that is valid at all levels of inversion starting from a simplified version of the Enz-Krummanacher-Vittoz model of the MOS transistor. This generalized translinear principle reduces to the conventional one when all transistors in a translinear loop are biased in weak inversion and it reduces to the voltage-translinear principle when all transistors in the loop are biased in strong inversion. We show experimental measurements from an alternating loop of four nMOS transistors that was fabricated in a 0.5-mum CMOS process through MOSIS to corroborate the generalized translinear principle. Finally, we discuss some potential applications of the principle.
DIME: portable software for irregular meshes for parallel or sequential computer

A programming environment for instructured triangular meshes has been written. The resulting software, DIME (distributed irregular mesh environment), is responsible for the mesh structure, and a separate application code runs a particular type of simulation on the mesh. DIME keeps track of the mesh structure, allowing mesh creation, reading and writing meshes to disk, and graphics. Adaptive refinement and certain topological changes to the mesh are included. It hides the parallelism from the application code and splits the mesh among the processors in an efficient way. The application code is responsible for attaching data to the elements and nodes of the mesh and for manipulating and computing with these data and the data from its mesh neighborhood. DIME is designed to be portable between different MIMD (multiple-instruction, multiple-data) parallel machines and also to run on any UNIX machine, treating this as a parallel machine with just one processor. >
CONSTITUTIONAL AND CONFIGURATIONAL ASPECTS OF THE THERMAL REORGANIZATION OF 1-CYANO-2-VINYLCYCLOBUTANE (I)

Kinetics and Arrhenius parameters have been determined for three processes: automerization, ring expansion and cycloreversion, occurring in the thermal reorganization of racemic cis and trans-I. Through the reorganization of optically active materials, automerization is trisected into enantiomerization and two epimeric diastereomerizations, and ring expansion is dissected into processes leading to enantiomeric 4-cyanocyclohexenes (II). Evidence pointing to concertedness being undiscernible, the system of reorganizations is classified as not obviously concerted and discussed in terms of relative propensities of groups to rotate internally. Comparison with similar cyclopropane systems reveals no qualitative differences (beyond cycloreversion) and only one substantial quantitative difference; that is, an enhanced tendency in the cyclobutane toward ring expansion.
Database Support for Discovering Patterns in Large Datasets Collected from Multiple Sensors

A large number of applications require mining high rate data streams. An important challenge in dealing with such data intensive applications is fast data change rate that requires improved analysis, new algorithms, tools and techniques. Our purpose for this work is to examine how to integrate collecting data streams from multiple sensors in order to discover new patterns and minimize the number of incorrect alarms. We present a framework for mining patterns from data streams and discuss practical applications.
A fuzzy velocity controller for DC drives

An investigation into the development of a fuzzy velocity controller for DC motor drives is presented. The controller development is based on a verbal performance objective which is intended to minimize the response time following a step change in load torque. This performance objective has been translated into separate fuzzy controllers for high and low inductance machines. The authors present the conceptual foundation for the fuzzy control, as well as details of the development of the fuzzy control implementation. Two classes of machines are identified, and simulation results are presented for both. A laboratory implementation has been developed for a two-horsepower, permanent-magnet machine using graphical programming on a 486 computer for the fuzzy control implementation. The initial results of this implementation show the effectiveness of the control. >
Decomposing Data-Centric Storage Query Hot-Spots in Sensor Networks

Arising when a large percentage of queries is accessing data stored in few sensor nodes, query hot-spots reduce the quality of data (QoD) and the lifetime of the sensor network. All current in-network data-centric storage (IN-DCS) schemes fail to deal with query hot-spots resulting from skewed query loads as well as skewed sensor deployments. In this paper, we present two algorithms to locally detect and decompose query hot-spots, namely zone partitioning (ZP) and zone partial replication (ZPR). We build both algorithms on top of the DIM scheme, which has been shown to exhibit the best performance among all INDCS schemes. Experimental evaluation illustrates the efficiency of ZP/ZPR in decomposing query hot-spots while increasing QoD as well as energy savings by balancing energy consumption among sensor nodes.
Asymptotic Synchronization of a Leader-Follower Network of Uncertain Euler-Lagrange Systems

This paper investigates the synchronization of a network of Euler-Lagrange systems with leader tracking. The Euler-Lagrange systems are heterogeneous and uncertain and contain bounded, exogenous disturbances. The network leader has a time-varying trajectory which is known to only a subset of the follower agents. A robust integral sign of the error-based decentralized control law is developed to yield semiglobal asymptotic agent synchronization and leader tracking.
Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy.

Cubilin is a 460-kDa multipurpose, multidomain receptor that contains an NH2-terminal 110-residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch (represen...
Selective Withdrawal Criteria of Stratified Fluids

A general criterion for the presence or absence of selective withdrawal in a fluid or arbitrary stratification due to a line sink in a channel is presented. Several examples are given. The criterion is based on whether the speed of upstream propagating columnar disturbances is greater or less than the initial uniform velocity induced by the line sink. The result is then extended to topographical influence in the form of a lateral contraction of the channel walls. Experiments were conducted and they verified the conclusions for the lateral contraction. The use of lateral contractions to insure uniform flow in a stratified channel or reservoir is indicated.
Prospective assessment of cost, morbidity, and survival associated with lymphadenectomy in low-risk endometrial cancer.

5004 Background: Since 1999, patients with low-risk endometrial cancer (EC) as defined by the Mayo criteria have preferably not undergone lymphadenectomy (LND) at our institution. We assess surviva...
Kalmár and Péter: Undecidability as a Consequence of Incompleteness

Laszlo Kalmar and Peter Rozsa “proved that the existence of (...) undecidable problems follows from Godel’s Theorem on relatively undecidable problems” ([6], p. vii). Unfortunately, the only available document of their joint work is Kalmar’s sketch of the proof in his [3]. In the following, I assemble a paper from Kalmar’s manuscripts on this issue.
The use of indocyanine green videoangiography to optimize the dural opening for intracranial parasagittal lesions.

BACKGROUND We describe our clinical experience with the use of indocyanine green (ICG) videoangiography to delineate the locations of the cortical draining veins before dural opening in 3 cases of parasagittal lesions. With this technique, the veins are marked through the dura, and then the dura can be opened precisely to avoid cortical venous injury. OBJECTIVE To demonstrate in a clinical series the adjunct use of intraoperative ICG angiography to optimize the dural opening for parasagittal lesions. METHODS We describe 3 cases of parasagittal lesions, 2 meningiomas, and 1 arteriovenous malformation treated using the described technique. RESULTS Once the dura had been exposed, ICG at a dose of 0.25 mg/kg was injected into the patient's peripheral vein as a bolus. When the dye reached the illuminated field of interest, ICG fluorescence was induced by the use of a light source with a wave-length ICG absorption band. Thereafter, the dural cortical veins were marked through the dura and precisely opened, avoiding cortical venous injury. CONCLUSION Indocyanine green video angiography is a safe, fast, inexpensive, and accurate investigation that allows the surgeon to strategically plan and protect important parasagittal dural venous drainage during craniotomy.
Millimeter-Sized Suspended Plasmonic Nanohole Arrays for Surface-Tension-Driven Flow-Through SERS

We present metallic nanohole arrays fabricated on suspended membranes as an optofluidic substrate. Millimeter-sized suspended nanohole arrays were fabricated using nanoimprint lithography. We demonstrate refractive-index-based tuning of the optical spectra using a sucrose solution for the optimization of SERS signal intensity, leading to a Raman enhancement factor of 107. Furthermore, compared to dead-ended nanohole arrays, suspended nanohole arrays capable of flow-through detection increased the measured SERS signal intensity by 50 times. For directed transport of analytes, we present a novel methodology utilizing surface tension to generate spontaneous flow through the nanoholes with flow rates of 1 μL/min, obviating the need for external pumps or microfluidic interconnects. Using this method for SERS, we obtained a 50 times higher signal as compared to diffusion-limited transport and could detect 100 pM 4-mercaptopyridine. The suspended nanohole substrates presented herein possess a uniform and reprodu...
Marital Histories and Heavy Alcohol Use among Older Adults

We develop a gendered marital biography approach—which emphasizes the accumulating gendered experiences of singlehood, marriage, marital dissolution, and remarriage—to examine the relationship between marital statuses and transitions and heavy alcohol use. We test this approach using individual-level (n = 10,457) and couple-level (n = 2,170) longitudinal data from the Health and Retirement Study, and individual-level (n = 46) and couple-level (n = 42) in-depth interview data. Quantitative results show that marriage, including remarriage, reduces men’s but increases women’s drinking relative to being never married and previously married, whereas divorce increases men’s but decrease women’s drinking, with some variation by age. Our qualitative findings reveal that social control and convergence processes underlie quantitative results. We call attention to how men’s and women’s heavy drinking trajectories stop, start, and change direction as individuals move through their distinctive marital biography.
Stability of Carbon Interphases and Their Effect on the Deformation of Fiber Reinforced Ceramic Matrix Composites

Time-dependent deformation behavior, in bending, of notched ceramic matrix composite samples was investigated at elevated temperatures under varying pO2. Materials studied consisted of a chemical vapor infiltrated (CVI) β-SiC matrix reinforced with Nicalon® SiC fibers with a 1μm C interphase. From these results, activation energies for composite deformation were obtained as a function of oxygen partial pressure. Finally Thermo-Gravimetric experiments were conducted to obtain the oxidation kinetics of the C interphase. The activation energy for oxidation was correlated to the activation energy for damage evolution.
Cancer Fatalism and Preferred Sources of Cancer Information: an Assessment Using 2012 HINTS Data

Cancer fatalism is associated with lower participation in cancer screening, nonadherence to cancer screening guidelines, and avoidance of medical care. Few studies, however, have examined the relationship between cancer fatalism and health information seeking. The purpose of this study was to examine the relationship between endorsement of fatalistic beliefs regarding cancer and preferred sources of cancer information. We analyzed data from the Health Information National Trends Survey 4 Cycle 2, which were collected in late 2012 and early 2013 (N = 3630). When weighted, the data are representative of the non-institutionalized US population aged 18 or older. In bivariate and multivariate analyses, we assessed three cancer fatalism beliefs as predictors of preferred use of healthcare provider versus preferred use of the Internet for cancer information. Results indicate the majority of US adults endorse one or more fatalistic beliefs about cancer. Unadjusted results indicate endorsing the fatalistic belief that "there's not much you can do to lower your chances of getting cancer" was significantly associated with lower odds of preferring the Internet (versus healthcare providers) as the source of cancer information (OR: 0.70; CI: 0.50, 0.98). In the adjusted model, however, none of the three cancer fatalism measures were significantly associated with preferred source of cancer information. In conclusion, fatalistic beliefs about cancer are common, and further research is warranted to understand cancer fatalism and whether and how it may impact health information-seeking behaviors.
Quantifying gene expression: the importance of being subtle

Gene expression is regulated at both the mRNA and protein level through on‐off switches and fine‐tuned control. In their recent study, Edfors et al (2016) use highly accurate, targeted proteomics methods and examine to what extent the amount of protein produced per mRNA transcript varies across different tissues. They find that the bulk part of protein concentrations is set at a per‐gene level: This relationship, the protein/mRNA ratio, is constant across cell types and tissues, but varies by several orders of magnitude across genes. Mol Syst Biol. (2016) 12: 885
Social Structure and Life History of Bottlenose Dolphins Near Sarasota Bay, Florida: Insights from Four Decades and Five Generations

Studies of social ecology can benefit from long-term observations, as these provide researchers with opportunities to distinguish between the relative contributions of life history, demographics, and ecological pressures to the development of social patterns. Long-term study can provide the means of interpreting changes in stable social patterns relative to changes in environmental factors or availability of members of specific age-sex classes. The strength of social patterns can be measured by their persistence from one generation to the next, and as individuals pass life history milestones.
Forms of the Grotesque in The Juniper Tree

This essay argues for the multifold relevance of the Bakhtinian grotesque to the Brothers Grimm tale The Juniper Tree . The woman’s pregnancy, described in relation to nature’s life-death cycle, represents both the grotesque on the individual body and its its larger role in the rebirth that it advances. The mother dies after giving birth. The father remarries an abusive woman who decapitates and cooks his son in a stew, which the father unknowingly eats. The tale highlights the carnivalesque song, “My Mother Slew Me, My Father Ate Me,” sung by a bird born from the tree where the son’s bones are buried. The tale’s interpolations of prose and verse become central to its depictions of Romantic moral development. The song functions as a cris de Paris to create a marketplace that advances dialogue. The performance further illuminates the grotesque and guides the narrative until justice is restored.
Confidential and authenticated communications in a large fixed-wing UAV swarm

Large Unmanned Aerial Vehicle (UAV) swarms are a nascent technology promising useful military and civilian solutions to logistical problems. Securing data communications within the swarm is essential to accomplishing swarm objectives. The Naval Postgraduate School has successfully demonstrated the launch, flight and landing of 50 UAVs. The communications architecture to support a UAV swarm is unique. This paper details the practical challenges of creating a secure communications channel in the swarm. The Advanced Encryption Standard (AES) was chosen as one of the encryption algorithms for testing as it is authorized by the National Security Agency (NSA). Various modes of AES, including Galois/Counter Mode (GCM) and Counter with Cipher Block Chaining Message Authentication Code (CCM), were analyzed within the swarm architecture. The impact of these authenticated encryption algorithms on network capacity and processor performance is presented. In addition to AES, ChaCha20-Poly1305, another type of authenticated encryption scheme was studied. It was found to be the better solution for securing the swarm if classified data is not being handled or created.
Sonographically Guided Iliopsoas Injection

Diagnostic or therapeutic injection/aspiration of iliopsoas (IP) bursa, anterior hip pain syndromes, snapping hip syndrome, and post-arthroplasty hip pain.