cssi/SciSciGPT-SciSciNet huggingface dataset:
Variations in crosslink organization in formaldehyde‐modified cotton celluloses

Rates of decrease in crystallinity, as measured by x-ray crystallinity index, have been followed throughout periodate oxidations of cotton cellulose and formaldehyde-treated cotton celluloses. Depending upon the conditions under which the agent was introduced, a low level of formaldehyde crosslinks exerted small or large retardation on the rate of decrease of crystallinity index. The extents of decrystallization per unit of oxidation of cotton and crosslinked cotton celluloses are substantially smaller in the initial phase of oxidation than in the later stage, indicative of preferential oxidative attack in the early stage on chain segments of predominantly noncrystalline regions. Relative to unmodified cotton, crosslinked cotton celluloses are characterized by more extensive decrystallization per unit of oxidation in the early phase of oxidative attack (to approx. 40%). From these data, supplemented by electron micrographs and solubilities in cupriethylenediamine hydroxide, uniformity of distribution of crosslinks is shown to increase in this series of formaldehyde-modified cotton celluloses (at the same level of agent) in the order: form D cotton (nonaqueous treatment) < form W cotton (aqueous treatment) < form V cotton (vapor treatment). Effectiveness of crosslinking (i. e., composite of number of linkages, ratio of intermolecular to intramolecular bonds, low degree of polymerization in crosslink) is indicated to increase from form W to form D to form V cotton.
High drama on the high seas Peace versus war journalism framing of an Israeli/Palestinian-related incident

A review of the literature indicates a plethora of studies examining the coverage of Middle Eastern conflicts, but hardly any research has been explicitly framed as being developed from a peace/war...
The Role of Cost Allocations in the Acquisition and Use of Common Resources

. For a common resource, we suggest that the benefits of fixed cost allocations lie not in inducing optimal utilization of available capacity but in deciding how much capacity to acquire. In the presence of sequential information asymmetry between the owner and two symmetric users of the resource, we show that cost allocations form a part of the optimal incentive contract. We derive an optimal cost allocation scheme and provide an explicit link between the allocated costs under this scheme and the fixed costs of the resource. Resume. Selon les auteurs, pour une ressource commune, les avantages de la repartition des couts fixes resident non pas dans l'induction d'une utilisation optimale de la capacite disponible, mais dans la decision relative a la capacite devant etre acquise. En presence d'asymetrie de l'information sequentielle entre le proprietaire et deux utilisateurs symetriques de la ressource, les auteurs demontrent que la repartition des couts est un element qui entre dans le contrat d'interessement optimal. Ils derivent un plan optimal de repartition des couts et etablissent un lien explicite entre les couts repartis au moyen de ce plan et les couts fixes de la ressource.
Tyrosine Phosphorylation of Rod Cyclic Nucleotide-Gated Channels Switches Off Ca2+/Calmodulin Inhibition

Cyclic nucleotide-gated (CNG) ion channels are crucial for phototransduction in rod photoreceptors. Light triggers a biochemical cascade that reduces the concentration of cGMP in rods, closing CNG channels, which leads to membrane potential hyperpolarization and a decrease in the concentration of intracellular Ca2+. During light adaptation, the sensitivity of CNG channels to cGMP is decreased by Ca2+, which in conjunction with calmodulin (CaM), binds directly to CNG channels. The cGMP sensitivity of rod CNG channels is also reduced by phosphorylation of specific tyrosine residues in the three CNGA1 subunits and one CNGB1 subunit that comprise the rod channel. Here we show that phosphorylation prevents Ca2+/CaM inhibition. Experiments on native channels in rod outer segments and expressed channels in Xenopus oocytes show that Ca2+/CaM inhibition can be toggled off or on by promoting phosphorylation or dephosphorylation, respectively. Experiments in which the crucial tyrosine phosphorylation sites in CNGA1 and CNGB1 are replaced with phenylalanines show that residue Y498 in CNGA1 is the phosphorylation site responsible for regulating Ca2+/CaM inhibition. Ca2+/CaM inhibits the rod channel by binding to the N terminus of the CNGB1 subunit, causing it to uncouple from the C terminus of CNGA1. We propose that phosphorylation of CNGA1Y498, on the C terminus of CNGA1, triggers an equivalent uncoupling from the C terminus of CNGB1, thereby curtailing Ca2+/CaM inhibition. The control of CaM inhibition by CNG channel phosphorylation may be important for light adaptation and the regulation of phototransduction by IGF-1, a retinal paracrine factor that alters the tyrosine phosphorylation state of rod CNG channels.
Accuracy of double-contrast barium enema in diagnosing colorectal polyps and cancer

Summary CRC is a common malignancy, and reduced mortality can be achieved through detection and treatment of early cancers and by removal of colonic adenomas. Although current screening recommendations, especially in the average-risk individual, typically promote the use of FOBT and FS, a substantial minority of colonic cancers and many colonic adenomas are not detected by these methods. Modalities that examine the entire colon, such as the barium enema and colonoscopy, can detect most clinically important colorectal neoplasms; however, their additional costs and potential risks have limited their use as initial screening examinations. But recent changes in governmental policies regarding reimbursement for CRC screening and increasing emphasis on total colon examinations have altered these recommendations. This review on the accuracy of the DCBE has emphasized the detection of colonic polyps and cancers and has updated the changing role of this examination in screening patients at variable risk for CRC. The efficacy of the barium enema depends on many factors that radiologists must understand and control to perform accurate examinations. Current recommendations for CRC screening and approved reimbursement of the barium enema for that purpose provide a new impetus to radiologists to maintain and improve their skills in performing and interpreting this radiologic examination. The barium enema may have a future in the new millennium.
Phosphorus retention in calcareous soils and the effect of organic matter on its mobility

A survey of the interactions between phosphorus (P) species and the components of calcareous soils shows that both surface reactions and precipitation take place, especially in the presence of calcite and limestone. The principal products of these reactions are dicalcium phosphate and octacalcium phosphate, which may interconvert after formation. The role of calcium carbonate in P retention by calcareous soils is, however, significant only at relatively high P concentrations – non-carbonate clays play a more important part at lower concentrations. In the presence of iron oxide particles, occlusion of P frequently occurs in these bodies, especially with forms of the element that are pedogenic in origin. Progressive mineralization and immobilization, often biological in nature, are generally observed when P is added as a fertilizer. Manure serves both as a source of subsurface P and an effective mobilizing agent. Blockage of P sorption sites by organic acids, as well as complexation of exchangeable Al and Fe in the soil, are potential causes of this mobilization. Swine and chicken manure are especially rich P sources, largely due the practice of adding the element to the feed of nonruminants. Humic materials, both native and added, appear to increase recovery of Olsen P. In the presence of metal cations, strong complexes between inorganic P and humates are formed. The influence of humic soil amendments on P mobility warrants further investigation.
Modeling Ancient Population Structures and Movement in Linguistics

▪ Abstract Linguistic population structure is described in terms of language families. Geographical distributions of language families respond to climate, latitude, and economic factors. Characteristic shapes of phylogenetic descent trees for language families reflect particular types, rates, directionalities, and chronologies of spread. Languages move in predictable ways in particular geographical, economic, and social contexts. In this chapter, the linguistic prehistories of four continents are surveyed with regard to linguistic spreads, linguistic diversity, and language family origins.
Efficient and deterministic application deployment in component-based enterprise distributed real-time and embedded systems

Context: Component-based middleware, such as the Lightweight CORBA Component Model, is increasingly used to implement enterprise distributed real-time and embedded (DRE) systems. In addition to supporting the quality-of-service (QoS) requirements of individual DRE systems, component technologies must also support bounded latencies when effecting deployment changes to DRE systems in response to changing environmental conditions and operational requirements. Objective: The goals of this paper are to (1) study sources of inefficiencies and non-deterministic performance in deployment capabilities for DRE systems and (2) devise solutions to overcome these performance problems. Method: The paper makes two contributions to the study of the deployment and configuration of distributed component based applications. First, we analyze how conventional implementations of the OMG's Deployment and Configuration (D&C) specification for component-based systems can significantly degrade deployment latencies. Second, we describe architectural changes and performance optimizations implemented within the Locality-Enhanced Deployment and Configuration Engine (LE-DAnCE) implementation of the D&C specification to obtain efficient and deterministic deployment latencies. Results: We analyze the performance of LE-DAnCE in the context of component deployments on 10 nodes for a representative DRE system consisting of 1000 components and in a cluster environment with up to 100 nodes. Our results show LE-DAnCE's optimizations provide a bounded deployment latency of less than 2s for the 1000 component scenario with just a 4 percent jitter. Conclusion: The improvements contained in the LE-DAnCE infrastructure provide an efficient and scaleable standards-based deployment system for component-based enterprise DRE systems. In particular, deployment time parallelism can improve deployment latency significantly, both during pre-deployment analysis of the deployment plan and during the process of installing and activating components.
THERAPEUTIC DISTANT ORGAN EFFECTS OF REGIONAL HYPOTHERMIA DURING MESENTERIC ISCHEMIA-REPERFUSION INJURY

Introduction Mesenteric ischemia-reperfusion injury (IRI) leads to systemic inflammation and multiple organ failure in clinical and laboratory settings. We investigated the lung structural, functional, and genomic response to mesenteric IRI with and without regional intraischemic hypothermia (RIH) in rodents and hypothesized that RIH would protect the lung and preferentially modulate the distant organ transcriptome under these conditions. Methods Sprague-Dawley rats underwent sham laparotomy or superior mesenteric artery occlusion (SMAO) for 60 minutes with or without RIH. Gut temperature was maintained at 15°-20°C during SMAO, and systemic normothermia (37°C) was maintained throughout the study period. At 6 or 24 hours, lung tissue was collected for (1) histology, (2) myeloperoxidase activity, (3) bronchoalveolar lavage (BAL) fluid protein concentrations, (4) lung wet/dry ratios, and (5) total RNA isolation and hybridization to Illumina's Sentrix BeadChips (>22,000 probes) for gene expression profiling. Significantly affected genes (false discovery rate Results Mesenteric IRI-induced lung injury, as evidenced by leukocyte trafficking, alveolar hemorrhage, and increased BAL protein and wet/dry ratios, and activated a proinflammatory lung transcriptome compared with sham. In contrast, rats treated with RIH exhibited lung histology, BAL protein, and wet/dry ratios similar to sham. At 6 hours, GO analysis identified 232 hypothermia-suppressed genes related to inflammation, innate immune response, and cell adhesion, and 33 hypothermia-activated genes related to lipid and amine metabolism and defense response. Quantitative real-time polymerase chain reaction validated select array changes in top hypothermia-suppressed genes lipocalin-2 (lcn-2) and chemokine ligand 1 (CXCL-1), prominent genes associated with neutrophil activation and trafficking. Conclusions Therapeutic hypothermia during SMAO provides distant organ protection and preferentially modulates the IRI-activated transcriptome in the rat lung. This study identifies potential novel diagnostic and therapeutic targets of mesenteric IRI and provides a platform for further mechanistic study of hypothermic protection at the cellular and subcellular level.
Discussion on China's Accounting Standards about the Introduction and Embodiment of Assets and Liabilities

This paper starts from the concept of assets and liabilities and focuses on the embodiment in new accounting standards.It believes that regulators and practitioners should be combined with the construction of China's accounting standards and should be updated the accounting concept.
Analysis of surveillance of highly pathogenic avian influenza in occupational exposure crowd and environment in Baiyin City

Objective To learn the infection of avian influenza in occupational exposure crowd and pollution situation of avian influenza virus H5, H7, and H9 subtypes in external environment, to provide a scientific basis for avian influenza prevention. Methods Regions with developed poultry industry were selected as the monitoring sites, and environmental samples and serological samples of occupationally exposed populations were collected and detected. The serum samples were detected for H5, H7 avian influenza antibodies with horse blood serum samples inhibition(HI) and the external environment samples were detected with avian flu virus nucleic acid method. Results Out of the 290 external environment specimens,49 specimens were positive of avian influenza viral nucleic acid with positive rate of 16.90%, including 48 specimens of H9 positive and 1 specimen of H7 probable positive. There was statistical difference(P0.05) in positive rate between various time(χ2=21.655) and various samples(χ2=16.934), and no statistical difference in positive rate among monitoring sites(χ2=1.203, P0.05). H5 and H7 antibodies of 200 sera of occupationally exposed crowd were negative. Conclusions There is no case subclinically infected with avian influenza in the exposure crowds in Baiyin City, but avian influenza virus H9 subtype is widespread in external environment. Avian influenza virus exists in transshipment center such as poultry sales market and poultry farms. Quarantine system for poultry trading market should be improved and epidemic prevention in poultry farms should be strengthened.
Electroencephalograms and evoked potentials. Monitoring cerebral function in the neurosurgical intensive care unit.

Electroencephalograms and evoked potentials detect central nervosus system impairment in intensive care unit patients. They quantify and localize the impairment, and sometimes specify a likely cause. Monitoring electroencephalograms allows one to identify some complications early enough to initiate early intervention. Electroencephalograms are particularly able to detect nonconclusive seizures causing diminished mental status in some intensive care unit patients.
Moving Forward with the Responsibility to Protect:Using Political Inertia to Protect Civilians

First formulated in 2005, the Responsibility to Protect has emerged onto the international legal landscape. This doctrine recently was expressed in the 2011 United Nations-authorized humanitarian intervention in Libya. Despite this promising start, the doctrine—designed to protect civilians from violence caused by their government or violence which the government is powerless to stop—has done nothing for the civilians in Syria. This Note explores the history of the Responsibility to Protect, identifies its flaws, analyzes proposed reforms, and ends with a suggested revision to the doctrine. This suggested revision would allow the political inertia of states to work for, rather than against, civilians.
THE OUTER-SENSE THEORY

The form of outer sense Kant uses the word ‘sensibility’ for one's capacity for being in any sort of sensory state. He says that this capacity is exercised in two ways: as outer sense , it permits one to have sensory states which are seeings, hearings, feelings etc. of things other than oneself; as inner sense , it permits one to have sensory states which may relate to one's environment but may be just states of oneself. Thus, all sensory states are mediated by inner sense, and some by outer sense as well: notwithstanding one queer remark suggesting the contrary, the proper contrast is not between ‘outer’ and ‘inner’ but between ‘outer (and also inner)’ and ‘only inner’. As Kant says: Whatever the origin of our [sensory states], whether they are due to the influence of outer things, or are produced through inner causes,…they must all, as modifications of the mind, belong to inner sense. Our present concern is with outer sense. In all the variety of my sensory awareness of the world there is, according to Kant, the constant factor that every one of these states of awareness is the end-product of a transaction between my sensibility and some part of the world outside me. Wherever and whenever it occurs, whatever fragment of the varied world it confronts me with, any ‘outer’ sensory state is given to me by my sensibility in its function as outer sense.
Impact of Multisensory Environments on Behavior for People With Dementia: A Systematic Literature Review.

Purpose of the study Behavioral and psychological symptoms of dementia (BPSD) affect quality of life for people with dementia. Nonpharmacological interventions are the preferred first line of treatment, and it is theorized that BPSD are directly influenced by sensory imbalance and improved by sensory equilibrium. The purpose of this article is to investigate the evidence regarding the use of multisensory environments (MSEs) as treatment for BPSD. Design and methods A systematic literature review was performed using the PICO framework within PsycINFO, Web of Science, ERIC, PubMED, and Cinahl databases, as well as additional hand-searched documents. Included articles were published during 1990 to 2015 and report empirical studies of MSE BPSD interventions that include furniture, fixtures, and equipment to provide visual, auditory, tactile, and olfactory stimulation. Desired elements include ergonomic vibroacoustic furniture, bubble tubes, color-changing lights, and fiber optics. Results Twelve articles met the inclusion criteria for review. Evidence supports the positive impact of sensory stimulation as a nonpharmacological behavioral treatment for dementia. Many studies investigated both behavior and mood, and several investigated biomedical parameters including heart rate and cognition. Significant differences were not found in the between-group studies when MSE was compared with other one-to-one interventions. Results on long-term effects were mixed. Variations can be seen in terms of research methods, types of environmental interventions, duration, and specific characteristics of participants, thus confounding the reliability of findings. Implications Key findings and directions for future research are discussed including primary outcomes, study design, environmental intervention types, and relevant assessment tools.
Implementation of an electronic surveillance database for patients with colorectal cancer.

231Background: An electronic surveillance database was created to monitor patients for five years following curative treatment for colorectal cancer. The database serves as an alert system and data repository for imaging, serology, and colonoscopy surveillance tests preloaded for each patient in accordance with NCCN guidelines based upon TNM cancer staging. Methods: The chiefs of Surgery and Oncology defined end-user specifications for the Filemaker Pro database. Key features include preloaded tests based upon NCCN guidelines, expected date of completion, and exam results. The database also tracks tests overdue or ordered but not yet obtained. A new workflow consisting of a monthly report of new colorectal cases from Pathology and a meeting of surgical and oncology physicians and physician assistants to review the report, update the database with new patients, and identify patients due for follow-up was established. Results: 250 cases are currently being monitored. By 2019, the database is poised to be th...
Physiological Data Significant to Participation by Women in Physical Activities

(1939). Physiological Data Significant to Participation by Women in Physical Activities. Research Quarterly. American Association for Health, Physical Education and Recreation: Vol. 10, No. 1, pp. 10-23.
APPLICATION OF A NUCLEAR POLYHEDROSIS VIRUS OF NEODIPRION TAEDAE LINEARIS ROSS ON PINE: PERSISTENCE AND EFFECT OF TIMING ON LARVAL MORTALITY

The persistence of a nuclear polyhedrosis virus (NPV) of the loblolly pine sawfly, Neodiprion taedae linearis Ross, on loblolly pine, Pinus taedae L., and the larval mortality in sawfly colonies sprayed from the ground during the egg stage were determined. When sawfly colonies and surrounding foliage on pine were sprayed with NPV one week prior to egg hatch, larval mortality was lower than in colonies treated as first-instar and was similar to mortality in colonies treated as third-instar. Percent larval mortality was not increased by the addition of 3.0% Shade® + 0.1% Trition CS-7 to the NPV suspension sprayed. Application of NPV at monthly intervals prior to egg hatch to either sawfly egg colonies and surrounding foliage or only to the foliage surrounding colonies resulted in loss of much of the NPV activity during the first month. Application of NPV at the highest rate (107 PIB/ml) to the eggs and surrounding foliage was the only treatment to significantly increase mortality over the untreated check at...
Influence of micro–structure on erosion resistance of plasma sprayed 7YSZ thermal barrier coating under gas turbine operating conditions

Abstract This paper presents the results of an experimental investigation of the effect of topcoat micro-structure on the erosion resistance of air plasma sprayed 7 wt% YSZ thermal barrier coating (TBC) at high temperature. Two sets of air plasma sprayed YSZ TBCs of differing micro-structures (porosities of 12.9 ± 0.5% and 19.5 ± 1.2%) were tested in a high temperature erosion tunnel to simulate modern gas turbine engine's operating conditions. The tests were conducted over a range of temperatures between 537 °C and 980 °C, gas velocities between 122 m/s and 305 m/s, and impingement angles between 20° and 90°. The two types of erodent powders used in the erosion tests were nominal 27 µm white fused Alumina and nominal 15 µm A3 test dust. The results demonstrate reduced erosion resistance associated with increased porosity in the topcoat layer.
Simulation methodology and performance analysis of network coding based transport protocol in wireless big data networks

Abstract The Multi-Path, Multi-Hop (MPMH) communications have been extensively used in wireless network. It is especially suitable to big data transmissions due to its high throughput. To provide congestion and end-to-end reliability control, two types of transport layer protocols have been proposed in the literature: the TCP-based protocols and the rateless coding based protocols. However, the former is too conservative to explore the capacity of the MPMH networks, and the latter is too aggressive in filling up the communication capacity and performs poorly when dealing with congestions. To overcome their drawbacks, a novel network coding scheme, namely, Adjustable Batching Coding (ABC), was proposed by us, which uses redundancy coding to overcome random loss and uses retransmissions and window size shrink to relieve congestion. The stratified congestion control strategy makes the ABC scheme especially suitable for big data transmissions. However, there is no simulation platform built so far that can accurately test the performance of the network coding based transport protocols. We have built a modular, easy-to-customize simulation system based on an event-based programming method, which can simulate the ABC-based MPMH transport layer behaviors. Using the proposed simulator, the optimal parameters of the protocol can be fine-tuned, and the performance is superior to other transport layer protocols under the same settings. Furthermore, the proposed simulation methodology can be easily extended to other variants of MPMH communication systems by adjusting the ABC parameters.
Use of a Pediatric Syncope Unit Improves Diagnosis and Lowers Costs: A Hospital-Based Experience

Objectives To assess the effect of a dedicated pediatric syncope unit on the diagnostic and therapeutic management of children with suspected syncope. We also evaluated the effectiveness of the pediatric syncope unit model in decreasing unnecessary tests and hospitalizations, minimizing social costs, and improving diagnostic yield. Study design This single-center cohort observational, prospective study enrolled 2278 consecutive children referred to Bambino Gesu Children's Hospital from 2012 to 2017. Characteristics of the study population, number and type of admission examinations, and diagnostic findings before the pediatric syncope unit was implemented (2012-2013) and after the pediatric syncope unit was implemented (2014-2015 and 2016-2017) were compared. Results The proportion of undefined syncope, number of unnecessary diagnostic tests performed, and number of hospital stay days decreased significantly (P Conclusions Pediatric syncope unit organization with fast-tracking access more appropriate diagnostic tests is effective in terms of accuracy of diagnostic yield and reduction of costs.
'One Magisterium: How Nature Knows Through Us' by Seán Ó Nualláin – A Review

Review of Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Sean O Nuallain: One Magisterium: How Nature Knows through Us published by Cambridge Scholars Publishing Ltd (Sept 2014) /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;} /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin;}
Sea Ice Distribution and Ice Use by Indigenous Walrus Hunters on St. Lawrence Island, Alaska

The hunting success of St. Lawrence Island walrus hunters from Savoonga (Sivungaq) and Gambell (Sivuqaq) is studied in relation to weather and sea ice conditions for the period 1979–2008. Satellite remote-sensing data, including ice concentration fields from passive-microwave radiometer data, have been examined over the entire time series in conjunction with walrus harvest data from two community-level monitoring programs. Important information to aid with interpretation of these data sets was provided by the hunters themselves, in particular through a log of ice conditions and ice use by L. Apangalook, Sr., of Gambell. From these data, we determined which ice conditions (concentrations >0 and 6 km) provide the most favorable conditions for the walrus hunt. The research demonstrated that at the local level, though not necessarily at the region-wide scale, the sea ice concentration anomaly is a very good predictor of the number of favorable hunting days. With the exception of 2007 (and to a lesser extent, 2008), negative anomalies (less ice or earlier onset of ice retreat) coincided with more favorable (Savoonga) or near-average (Gambell) hunting conditions, controlled mostly by access to ice-associated walrus. Ice access and temporal variability differ significantly between Savoonga and Gambell; in contrast with northern Alaska communities, St. Lawrence hunters were able to maintain typical levels of harvest success during the recent record – low ice years of 2007 and 2008. We discuss the potential value of data such as assembled here in assessing vulnerability and adaptation of Arctic communities depending on marine-mammal harvests to climate variability and change.
Modulating the σ-Accepting Properties of an Antimony Z-type Ligand via Anion Abstraction: Remote-Controlled Reactivity of the Coordinated Platinum Atom

In search of ligand platforms, which can be used to remotely control the catalytic activity of a transition metal, we have investigated the coordination noninnocence of ambiphilic L2/Z-type ligands containing a trifluorostiborane unit as a Lewis acid. The known dichlorostiboranyl platinum complex (( o-(Ph2P)C6H4)2SbCl2)PtCl (1) reacts with TlF in the presence of acetonitrile (MeCN) and cyclohexyl isocyanide (CyNC) to afford the trifluorostiborane platinum complexes 2 ((( o-(Ph2P)C6H4)2SbF3)Pt-NCMe) and 3 ((( o-(Ph2P)C6H4)2SbF3)Pt-CNCy), respectively. Formation of these complexes, which results from a redistribution of the halide ligands about the dinuclear core, affects the nature of the Pt-Sb bond. The latter switches from covalent in 1 to polar covalent (or dative) in 2 and 3 where the trifluorostiborane moiety engages the platinum center in a Pt → Sb interaction. The polarity of the Pt-Sb bond can be modulated further by abstraction of an antimony-bound fluoride ligand using B(C6F5)3. These reactions afford the cationic complexes [(( o-(Ph2P)C6H4)2SbF2)Pt-NCMe]+ ([5]+) and [(( o-(Ph2P)C6H4)2SbF2)Pt-CNCy]+ ([6]+) which have been isolated as [BF(C6F5)3]- salts. These complexes possess a highly Lewis acidic difluorostibonium moiety, which exerts an intense draw on the electron density of the platinum center. As a result, the latter becomes significantly more electrophilic. In the case of [5]+, which contains a labile acetonitrile ligand, this increased electrophilicity translates into increased carbophilicity as reflected by the ability of this complex to promote enyne cyclization reactions. These results demonstrate that the coordination noninnocence of antimony Z-ligands can be used to adjust the catalytic activity of an adjoining metal center.
Cisplatin versus cetuximab with definitive concurrent radiotherapy for head and neck squamous cell carcinoma: An analysis of Veterans Health Affairs data.

BACKGROUND The addition of cisplatin or cetuximab to radiation therapy (RT) improves outcomes in comparison with RT alone in the nonoperative management of head and neck squamous cell carcinoma (HNSCC), but limited data exist for comparing these approaches. Using Veterans Health Affairs data, this study compared the outcomes of patients treated with RT plus cisplatin or cetuximab. METHODS Patients with stage III to IVb HNSCC who had been treated nonsurgically with RT and cisplatin or cetuximab from 2000 to 2016 within the Veterans Health Affairs system were identified. Patients were analyzed by the drug used in the first treatment cycle (intent to treat). Overall survival (OS) was compared by treatment group with Cox regression models, and propensity score (PS) methods were used to account for a treatment allocation bias. The risk of toxicities was determined, with logistic regression models fit into propensity-matched cohorts. RESULTS A total of 4520 patients were included in the analysis with a median follow-up of 3 years: 83% received cisplatin. Cisplatin patients were younger (P < .001) and had fewer comorbidities (P < .001). In an unmatched analysis, cetuximab was associated with inferior OS (P < .001). After PS matching, cetuximab treatment remained statistically significantly associated with inferior OS (1.7 vs 4.1 years; hazard ratio, 1.61; 95% confidence interval, 1.44-1.79; P < .001). These differences remained significant across all primary HNSCC subsites and in comparison with low- and high-dose cisplatin. CONCLUSIONS Cetuximab with RT yields inferior OS in comparison with cisplatin for the nonoperative management of stage III to IVb HNSCC. According to this study, cisplatin may be the most appropriate partner for RT in this setting.
Dinitrogen Coupling to a Terpyridine-Molybdenum Chromophore Is Switched on by Fermi Resonance

Summary The traditional view of a chemical change is inherently local and classical, and such a change relies on a mix of thermodynamic and kinetic parameters to control reactivity. Often, the thermodynamic stability of chemical bonds necessitates significant energy input for activation. One fundamental question is potentially transformative: can quantum mechanics enable selective bond activation? A possible approach involves strategic input of energy to reaction-specific vibrational levels. Toward this goal, our work describes the coupling of vibrational motions in a terpyridine-molybdenum complex hosting a nonreactive substrate—dinitrogen. Ultrafast coherence spectroscopies revealed a Fermi-resonance coupling mechanism connecting in-plane breathing motion of the light-harvesting terpyridines with the stretching motion of the spatially disparate dinitrogen bridge. Notably, the coupling is significantly enhanced in the photoexcited state. This Fermi resonance indicates an energy conduit that drives the two motions in sync and thereby amplifies vibrational energy exchange. Achieving selective bond activation by bridging vibrations could present a quantum-inspired design principle in synthetic chemistry.
Quantitative Imaging of Alpha-Emitting Therapeutic Radiopharmaceuticals

Targeted alpha therapy (TAT) is an active area of drug development as a highly specific and highly potent therapeutic modality that can be applied to many types of late-stage cancers. In order to properly evaluate its safety and efficacy, understanding biokinetics of alpha-emitting radiopharmaceuticals is essential. Quantitative imaging of alpha-emitting radiopharmaceuticals is often possible via imaging of gammas and positrons produced during complex decay chains of these radionuclides. Analysis of the complex decay chains for alpha-emitting radionuclides (Tb-149, At-211, Bi-212 (decayed from Pb-212), Bi-213, Ra-223, Ac-225, and Th-227) with relevance to imageable signals is attempted in this mini-review article. Gamma camera imaging, single-photon emission computed tomography, positron emission tomography, bremsstrahlung radiation imaging, Cerenkov luminescence imaging, and Compton cameras are briefly discussed as modalities for imaging alpha-emitting radiopharmaceuticals.
Editorial introduction: questioning inclusion in business, policy, and public values

While much of the scholarship on Responsible Innovation (RI) and Responsible Research and Innovation (RRI) has focused on work being done in university environments, this issue of the Journal of Re...
Method To Directly Measure and Actively Control a Single Nucleation-Crystal Growth Process

Nucleation and subsequent phase transitions exist broadly in nature and engineered processes, from ice formation to protein crystallization and beyond. The lack of capable methods to analyze and to control the dynamic heterogeneous process is a fundamental problem, and constitutes overwhelming technical challenges in synthesizing crystalline structures with designed/predictable properties. By actively controlling mass transport through a single nanopipette, the extent of supersaturation is adjusted kinetically in a confined space immediately outside the nanopore. Using protein insulin as prototype, the formation of a single atto-femto-liter droplet, subsequent nucleation inside and further growth of a single crystal, is monitored electrically and optically, and actively controlled by an external electrical field. The generalizable method, referred to as nanoAC for nanoscale active control, not just provides fundamental insights at unprecedented single entity resolution, it enables active in situ control o...
Geometry Tuning of an Electrically Small Antenna for Ionospheric Heating

A modification of a previously introduced electrically small antenna is presented with tuning methods for continuous band coverage for ionospheric heating (∼3–10 MHz). Consisting of a small loop antenna inductively coupled to a capacitively loaded loop (CLL), the design may be tuned ±50% of the center of the band by simply adjusting the capacitance of the CLL. Abandoning the use of lossy materials for tuning such as solid dielectrics or ferrites, the antenna is greater than 80% efficient across its tuning range. A tenth scale prototype with electromechanical geometry tuning is tested for frequency range and tuning capability especially at the low-frequency end where port reflection losses tend to dominate. Tuning of the small loop antenna-CLL coupling is used to mitigate this matching issue, which was demonstrated on the physical antenna model. Experimentally, a tuning range of 33.5–117.5 MHz is achieved with low reflection achievable across the range.
Gender Dynamics and Critical Reception: A Study of Early 20th-century Book Reviews from The New York Times

This paper focuses on book reviews at the turn-of-the century United States in order to underline fundamental compatibilities between large-scale, computational methods and book historical approaches. It analyzes a dataset of approximately 2,800 book reviews published in The New York Times between January 1, 1905 and December 31, 1925. Several machine learning scenarios are employed to investigate how the underlying reviews constructed gendered norms for reading and readership. Logistic regression models are trained and tested to evaluate how effectively lemma frequencies predict the perceived or presumed gender of an author under review. The paper discusses four different feature selection scenarios, as follows: (1) No terms removed, (2) Stop words removed, (3) Stop words, gender nouns, and titles removed, and (4) Stop words, gender nouns, titles, and common forenames removed. For each scenario, the top lemma coefficients are discussed and interpreted. Tracing the norms (gendered and gendering) of The New York Times Book Review in the early twentieth century demonstrates that even the summary-driven book reviews played an important role in mediating hierarchies of taste and distinction. Further, the paper seeks to demonstrate that cultural analytics methods can be used to investigate a range of research questions related to authorship, publishing, circulation, and reception.
Sedated Echocardiograms Better Characterize Branch Pulmonary Arteries Following Bidirectional Glenn Palliation with Minimal Risk of Adverse Events.

Patients post-bidirectional Glenn (BDG) operation are at risk of left and right pulmonary artery (LPA and RPA) hypoplasia. Transthoracic echocardiograms (TTE) in active children can miss essential elements of anatomy. Procedural sedation improves image quality but increases risk of adverse events. We hypothesized that echocardiograms performed with sedation in patients post-BDG would improve visualization of branch pulmonary arteries with minimal adverse events. Patients post-BDG between 2007–2016 were identified. Exclusion criteria were > 12 months of age, absence of complete TTE before discharge, death before discharge, conversion to shunt physiology, and prolonged post-operative course > 7 weeks. Of 254 post-BDG patients, 153 met inclusion/exclusion criteria. TTE reports were reviewed for visualization of LPA/RPA and hypoplasia of LPA/RPA. Blinded assessment of image quality was performed (scale of 1[poor] to 5[excellent]). Pertinent clinical data were recorded. Pearson’s chi-squared and Wilcoxon Rank Sum tests used for statistical analysis. The median age at surgery and hospital stay were 4.8 months and 10 days. Twenty-three patients underwent sedated TTE (15%). Sedated TTE significantly improved visualization of the RPA (100% vs 82%, p = 0.029) and LPA, though this did not reach statistical significance (100% vs 91%, p = 0.129). Sedated TTEs has significantly better image quality (median of 4 vs 3, p < 0.001). There were no serious adverse events due to sedation. Sedated TTE early post-BDG is safe, improves visualization of the RPA and LPA, and improves overall image quality. Routine sedated TTE in these patients should be considered. Implications for long-term outcome need to be further analyzed.
The genome of a nonphotosynthetic diatom provides insights into the metabolic shift to heterotrophy and constraints on the loss of photosynthesis

Abstract Although most of the tens of thousands of diatom species are obligate photoautotrophs, many mixotrophic species can also use extracellular organic carbon for growth, and a small number of obligate heterotrophs have lost photosynthesis entirely. We sequenced the genome of a nonphotosynthetic diatom, Nitzschia sp. strain Nitz4, to determine how carbon metabolism was altered in the wake of this rare and radical trophic shift in diatoms. Like other groups that have lost photosynthesis, the genomic consequences were most evident in the plastid genome, which is exceptionally AT-rich and missing photosynthesis-related genes. The relatively small (27 Mb) nuclear genome did not differ dramatically from photosynthetic diatoms in gene or intron density. Genome-based models suggest that central carbon metabolism, including a central role for the plastid, remains relatively intact in the absence of photosynthesis. All diatom plastids lack an oxidative pentose phosphate pathway (PPP), leaving photosynthesis as the main source of plastid NADPH. Consequently, nonphotosynthetic diatoms lack the primary source of NADPH required for essential biosynthetic pathways that remain in the plastid. Genomic models highlighted similarities between nonphotosynthetic diatoms and apicomplexan parasites for provisioning NADPH in their plastids. The ancestral absence of a plastid PPP might constrain loss of photosynthesis in diatoms compared to Archaeplastida, whose plastid PPP continues to produce reducing cofactors following loss of photosynthesis. Finally, Nitzschia possesses a complete β-ketoadipate pathway. Previously known only from fungi and bacteria, this pathway may allow mixotrophic and heterotrophic diatoms to obtain energy through the degradation of abundant plant-derived aromatic compounds.
Prognostic Factors for Pediatric Acute Encephalopathy Associated with Severe Brain Edema.

BACKGROUND AND OBJECTIVE Acute encephalopathy is a life-threatening brain dysfunction in children, often associated with a preceding infection and diffuse noninflammatory brain edema. At present, the role of decompressive craniectomy (DC) over the swollen area of the brain is unclear. The risk factors for predicting clinical deterioration also need clarification. METHODS A retrospective study of pediatric patients admitted between 2015 and 2019 with acute cerebral encephalopathy was carried out. Patients were classified according to: (1) the preceding pathogens, (2) the syndromic classification, and (3) the extent of brain edema. The syndromic classification is a relatively new classification of acute encephalopathy proposed in 2016 and divides patients into 3 groups: those with systemic inflammatory reactions or "cytokine storms" (group 1), those with status epilepticus but no cytokine storm (group 2), and others (group 3). Glasgow Outcome Scale (GOS) scores of 1-3 were defined as unfavorable, while a GOS score of 4 or 5 was defined as a favorable outcome in this study. DC was performed for select patients with life-threatening signs of brainstem compression. RESULTS Nineteen patients (mean age: 23.3 months) were included in the study, 8 (42.1%) of whom had an unfavorable outcome. There was no significant correlation between the types of pathogens and outcome. Unfavorable outcomes were observed in significantly more patients in group 1 (87.5%) than group 2 (14.3%) and group 3 (0%). There was a significant association between diffuse brain edema and unfavorable outcomes (72.7%). Neurosurgical DC was performed in 2 patients to alleviate life-threatening brainstem compression: one with a cytokine storm and diffuse bilateral brain edema, and the other with prolonged status epilepticus causing diffuse right-sided brain edema. The GOS score was 3 and 4, respectively. CONCLUSION The risk factors for clinical deterioration in pediatric acute encephalopathy were evaluated based on a variety of classifications, including the new syndromic classification. Laboratory features of cytokine storms and radiological evidence of diffuse brain edema were associated with unfavorable outcomes. The role of surgical decompression is still controversial and should be assessed on a case-by-case basis.
Discretionary Relief From Deportation: Replacing the Comparable-Grounds Approach to Former Immigration and Nationality Act Section 212(c)

Under section 212(c) of the former Immigration and Nationality Act, certain excludable individuals (individuals who may be prevented from entering the United States) could seek relief from exclusion and gain entrance at the discretion of the Attorney General. Over the course of several decades, a series of Supreme Court decisions expanded this discretionary relief to individuals who were deportable due to the commission of certain crimes. But this expansion created confusion: the Board of Immigration Appeals (BIA) had to grapple with the problem of determining exactly which deportable individuals could seek relief. The difficulty was that the grounds for deportation were different from the grounds for exclusion. In 1979, the BIA held that “section 212(c) applied only to those charges of deportability for which there was a comparable ground of inadmissibility.” Put another way, the question became: does the particular ground for deportation or removal have a statutory counterpart in the provisions for exclusion or inadmissibility? This case note examines the Supreme Court’s decision in Judulang v. Holder, 132 S.Ct. 476 (2011). It discusses the evolution of the BIA's comparable-grounds approach to determining eligibility for discretionary relief from deportation, the difficulties lawyers and judges face in light of this decision, and the possibilities upon remand.