cssi/SciSciGPT-SciSciNet huggingface dataset:
Trajectory Generation with Player Modeling

The ability to perform tasks similarly to how a specific human would perform them is valuable in future automation efforts across several areas. This paper presents a \(k\)-nearest neighbor trajectory generation methodology that creates trajectories similar to those of a given user in the Space Navigator environment using cluster-based player modeling. This method improves on past efforts by generating trajectories as whole entities rather than creating them point-by-point. Additionally, the player modeling approach improves on past human trajectory modeling efforts by achieving similarity to specific human players rather than general human-like game-play. Results demonstrate that player modeling significantly improves the ability of a trajectory generation system to imitate a given user’s actual performance.
Hyperplastic callus formation in osteogenesis imperfecta simulating osteosarcoma.

Massive callus formation following fracture in osteogenesis imperfecta may on rare occasions be so exuberant as to produce a clinical picture indistinguishable from osteogenic sarcoma. Recent case reports of proved sarcomatous change in two cases of osteogenesis imperfecta reaffirm the necessity for accurate diagnosis. Twenty-three reported cases of massive callus formation without sarcoma are reviewed and two cases are added. The only abnormal laboratory values even in advanced cases are elevated sedimentation rate and elevated serum alkaline phosphatase. Radiation therapy afforded rapid symptomatic relief in one patient and in the other it was given early in the process and seemed to halt further exuberant callus formation. Reconstructive surgery may be useful. It was carried out twice in one patient without eliciting abundant callus formation. Biopsy be necessary on occasion. The importance of accurate diagnosis is stressed since, in the twenty-one cases reported in the literature, nine amputations were advised and three were actually performed for what were later proved to be benign conditions.
BISQUE: locus- and variant-specific conversion of genomic, transcriptomic and proteomic database identifiers

UNLABELLED Biological sequence databases are integral to efforts to characterize and understand biological molecules and share biological data. However, when analyzing these data, scientists are often left holding disparate biological currency-molecular identifiers from different databases. For downstream applications that require converting the identifiers themselves, there are many resources available, but analyzing associated loci and variants can be cumbersome if data is not given in a form amenable to particular analyses. Here we present BISQUE, a web server and customizable command-line tool for converting molecular identifiers and their contained loci and variants between different database conventions. BISQUE uses a graph traversal algorithm to generalize the conversion process for residues in the human genome, genes, transcripts and proteins, allowing for conversion across classes of molecules and in all directions through an intuitive web interface and a URL-based web service. AVAILABILITY AND IMPLEMENTATION BISQUE is freely available via the web using any major web browser (http://bisque.yulab.org/). Source code is available in a public GitHub repository (https://github.com/hyulab/BISQUE). CONTACT haiyuan.yu@cornell.edu SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
On the Optimal Design of Hierarchical Organizations

In economic literature the suitability of relative performance evaluation for achieving better solutions to multiple agent problems is widely known. Most incentive mechanisms of this type implement ‘competitive’ equilibria in the subgames played by the agents. A widely ignored alternative is to tolerate coordinated decision making instead. We term this kind of organizational design ‘cooperation’. By allowing cooperation the principal may achieve higher payoffs than in the competitive case. The principal should therefore consider granting cooperation. In addition, he has to determine the permission’s extent. Perhaps, certain restrictions are given by strategic planning decisions. Or, more ambitious, one may ask what mixture of cooperation and competition predominates from the incentive point of view. Following the second approach, agency theory may contribute new insights into decisions due to organizational design.
Correlates of Integrated Marketing Communications

ABSTRACT The objective of this research was to identify factors that are significantly related to the degree of integration of a company9s marketing communications activities. A three-item scale was developed to measure integrated marketing communications in a cross-sectional sample of senior marketing managers in U.S. companies. Results show that firms whose marketing communications programs tend to be integrated are also likely to be small, consumer-focused, service-oriented companies. They are also more common in manufacturing, agriculture, forestry, and mining industries. Managers in firms with greater integration also tend to be more experienced, and their products or services are more likely to be experiencing market share growth. Implications of these findings for marketing communications managers and researchers are then discussed.
Symposium on reproduction of arthropods of medical and veterinary importance. I. Insect gametogenesis.

In higher insects both the male and female gametocytes undergo cycles of mitoses accompanied by incomplete cytokinesis. This results in clusters of sister cells joined to one another by systems of canals. The final number of joined “cystocytes” is constant for a given species and sex. Subsequently all male cystocytes, but only 1 female cystocyte in a cluster complete meiosis. The remaining female cystocytes grow and transfer cytoplasmic components through the canal system to the oocyte. Endomitosis in these “nurse cells” serves to multiply the cistrons that transcribe the components of the ribosomes which are assembled and then stored in the ooplasm in vast numbers. In the nuclei of oocytes and spermatocytes only 1 chromosomal replication cycle takes place, and this is generally followed by the assembly of synaptonemal complexes. Crossingover occurs, and the chiasmata which result keep the bivalents intact until the first meiotic division. The meiotic divisions of the oocyte are unique in that they occur in the absence of centrioles. The fertilizing sperm brings in a centriole, and this generates the centrioles required for subsequent cleavages. In Drosophila melanogaster studies of aberrant forms of gametogenesis in insects possessing mutant genes that markedly influence their fertility provide insights into the genetic control of these phenomena.
Presence of the calf affects secretion of prolactin in cows.

SummaryProlactin in sera of four cows subjected to 30 min of continuous milking increased from 28 ± 9 ng/ml before milking to a peak of 290 ± 29 ng/ml at 20 min, and averaged 229 ± 32 ng/ml at 30 min. In comparison with 25 cows maintained in the absence of their offspring on Day 2 postpartum, 23 cows maintained immediately adjacent to their calves (suckling not permitted) decreased basal-, milking-, and TRH-induced release of prolactin by 68, 69, and 29%, respectively, on Days 3 to 5 postpartum. We conclude that direct tactile stimulation of teats maintains increased secretion of prolactin, whereas presence of the calf immediately adjacent to their mothers but without suckling, does not stimulate secretion of prolactin. Indeed, the presence of the calf may be inhibitory to the secretion of prolactin in lactating cows.
Application value of combined detection of serum total bile acid and liver function enzymes in clinical diagnosis of liver diseases

Objective To explore the application value of combined detection of serum total bile acid and liver function enzymes in clinical diagnosis of liver diseases. Methods There were 120 patients with liver disease treated patients(including 30 cases, 50 cases of acute hepatitis, cirrhosis and hepatocellular carcinoma in 40 cases) and 40 cases of healthy as control group from June 2012 to September 2013 in our hospital, the serum TBA and liver function enzymes were detected in each group were compared, concentration index. Results In acute hepatitis group, liver cirrhosis group and liver cancer group and healthy group, serum TBA, ALT, AST, GGT and ALP level was significantly higher; acute liver inflammatory group had the highest TBA level, liver cirrhosis group, hepatic carcinoma group were lower than TBA level in acute hepatitis group(P0.05). Conclusion The combined detection of serum total bile acid and liver function enzymes in clinical practice for the understanding and diagnosis of liver disease have a certain significance, so it is worthy of clinical popularization.
Aggressive Treatment of Metastatic Renal Cancer

AbstractRadical nephrectomy and excision of metastases were performed in 21 patients with metastatic renal cell carcinoma. Followup was 12 years. Eight patients had metastases at the time of diagnosis and survived an average of 54 months, with 50 per cent alive 5 years postoperatively. Metastases developed after nephrectomy for localized disease in 13 patients. After extirpation of the secondary lesions these 13 patients survived an average of 38 months and 25 per cent were alive at 5 years. Survival varied with the length of time free of disease. Patients in whom metastases developed later than 2 years after nephrectomy survived 55 months compared to only 22 months for those in whom metastases developed earlier. Survival also was influenced by tumor aggressiveness (reflected by prognostic index number) and completeness of surgical excision of the secondary lesion.
Second-trimester markers of fetal size in schizophrenia: a study of monozygotic twins.

OBJECTIVE: Since the second prenatal trimester is the critical period of massive neural cell migration to the cortex, and fingertip dermal cells migrate to form ridges during this same period, the authors sought to determine whether there are differences in fingertip ridge count in pairs of monozygotic twins discordant for schizophrenia, possibly indicating that a prenatal anatomical insult affected the twins differently. METHOD: The fingertip dermal ridges of 30 pairs of monozygotic twins (23 pairs in which the twins were discordant for schizophrenia and seven pairs in which both twins were normal) were counted by two persons trained in anthropometric research. Intrapair differences in the counts were then measured, and the differences among the pairs of normal twins were compared with the differences among the pairs discordant for schizophrenia. RESULTS: The twins discordant for schizophrenia had significantly greater absolute intrapair differences in total finger ridge count and significantly greater percent intrapair differences than the normal twins; i.e., their fingerprints were significantly less "twin-like." CONCLUSIONS: The study suggests that various second-trimester prenatal disturbances in the epigenesis of one twin in a pair discordant for schizophrenia may be related to the fact that only one of the twins expresses his or her genetic predisposition toward schizophrenia. This is consistent with a "two-strike" etiology of schizophrenia: a genetic diathesis plus a second-trimester environmental stressor.
Working within the System: The Effects of Standardized Testing on Education Outreach and Community Writing

This snapshot describes and reflects upon two case studies community writing projects between Emerson College and Boston Public Schools. E merson College students were asked to tutor 10th grade BPS students for the English Language Arts portion of the state standardized assessment. Through both quantitative results and qualitative reflection, this paper suggests that a pproaching such standardized tests as a distinct genre of writing can not only help students to gain awareness for multiple genres, but also to recognize their own writing as an empowered and meaningful political form of social action. Keywords: community writing, public education, tutoring, standardized tests, genre
Mild Pro-Inflammatory State and Anemia in Older Persons.

Aging is characterized by a progressive dysregulation of homeostatic equilibrium. Inflammation is perhaps the most studied aspect of such homeostatic dysregulation, particularly in the context of anemia. Older persons and even “extremely healthy” older individuals are often affected by a mild pro-inflammatory state marked by high levels of pro-inflammatory markers, such as IL-6 and C-reactive protein (CRP). Patients with overt inflammatory diseases tend to develop anemia, usually of mild severity. Four mechanisms by which inflammation may affect anemia have been hypothesized: inhibition of proliferation and differentiation of erythroid precursors by inflammatory cytokines and/or downregulation of the EPO biological response; blunted EPO production; upregulation of hepcidin synthesis and consequent impairment of intestinal absorption and iron recycling; and reduced erythrocyte survival, not fully compensated by increased erythropoiesis. Studies have shown that the pro-inflammatory state of aging inflammation is associated with EPO levels higher than expected in non-anemic individuals and lower than expected in anemic individuals, suggesting the existence of a pre-anemic state where EPO resistance is compensated by increased EPO levels. Only when this compensatory mechanism fails does anemia become clinically evident. Consistent with this hypothesis, individuals with high EPO and high levels of inflammatory markers are at high risk of developing anemia. The mediating role of hepcidin in the pathogenesis of anemia of inflammation is suggested by an extensive literature. By interacting with the unique iron transporter, ferroportin, hepcidin controls iron intestinal absorption and mobilization from hepatocytes and macrophages, thereby causing low serum iron and ineffective erythropoiesis. Patients affected by disease characterized by overt inflammation, such as rheumatoid arthritis, abscess, and sepsis, show increased hepcidin urinary excretion. There is some evidence that the mild-pro-inflammatory state of aging does not cause hepcidin upregulation, although it is associated with low serum iron, lower transferrin saturation, and higher ferritin concentration. Thus, the iron lowering effect of moderate inflammation may be mediated by some still-unknown mechanism other than hepcidin. Studies are needed to test the hypothesis that the mild inflammation affects erythrocyte lifespan.
Integrated 3D printing and corona poling process of PVDF piezoelectric films for pressure sensor application

This paper presents a novel process to fabricate piezoelectric films from polyvinylidene fluoride (PVDF) polymer using integrated fused deposition modeling (FDM) 3D printing and corona poling technique. Corona poling is one of many effective poling processes that has received attention to activate PVDF as a piezoelectric responsive material. The corona poling process occurs when a PVDF polymer is exposed to a high electric field created and controlled through an electrically charged needle and a grid electrode under heating environment. FDM 3D printing has seen extensive progress in fabricating thermoplastic materials and structures, including PVDF. However, post processing techniques such as poling is needed to align the dipoles in order to gain piezoelectric properties. To further simplify the piezoelectric sensors and structures fabrication process, this paper proposes an integrated 3D printing process with corona poling to fabricate piezoelectric PVDF sensors without post poling process. This proposed process, named 'Integrated 3D Printing and Corona poling process' (IPC), uses the 3D printer's nozzle and heating bed as anode and cathode, respectively, to create poling electric fields in a controlled heating environment. The nozzle travels along the programmed path with fixed distance between nozzle tip and sample's top surface. Simultaneously, the electric field between the nozzle and bottom heating pad promotes the alignment of dipole moment of PVDF molecular chains. The crystalline phase transformation and output current generated by printed samples under different electric fields in this process were characterized by a Fourier transform infrared spectroscopy and through fatigue load frame. It is demonstrated that piezoelectric PVDF films with enhanced β-phase percentage can be fabricated using the IPC process. In addition, mechanical properties of printed PVDF was investigated by tensile testing. It is expected to expand the use of additive manufacturing to fabricate piezoelectric PVDF-based devices for applications such as sensing and energy harvesting.
Recurrent Tumors Referred for Mohs Micrographic Surgery: A 12-Year Experience at a Single Academic Center.

BACKGROUND Mohs micrographic surgery (MMS) is used for treatment of primary and recurrent tumors. Compared with primary tumors, recurrent tumors are often more aggressive. OBJECTIVE To understand differing characteristics between primary versus recurrent tumors treated by MMS. MATERIALS AND METHODS The authors conducted a retrospective review of a 12-year period at 1 academic center. Recurrent tumors were defined as recurrent if previously treated with cryotherapy, topical chemotherapeutics, electrodesiccation and curettage, or excision. Statistical analysis was conducted with p ≤ .05 considered significant. RESULTS A total of 17,971 cases were reviewed, of which 10.5% represented recurrent tumors. Recurrent tumors occurred more commonly in men (ratio 2.2:1). They presented in older individuals (p < .01) and occurred more commonly on the scalp (p < .0001), neck (p < .0001), and trunk (p < .0001). Primary tumors were more commonly located on the periocular (p < .0001), nose (p < .0001), and perioral areas (p < .0001). Squamous cell carcinoma more commonly presented as primary tumors (p = .02) while squamous cell carcinoma in situ more commonly presented as recurrent tumors (p < .001). CONCLUSION Distinct characteristics separate primary and recurrent tumors treated by MMS. Primary tumors were more commonly located in Area H, compared with recurrent tumors, which were more commonly located in Area M. This suggests appropriate usage of MMS based on appropriate use criteria.
Cholinesterase Inhibitors Do More than Inhibit Cholinesterase

The cholinergic system plays an important role in learning and memory processes. The crucial role of acetylcholine (ACh) is supported by three lines of evidence. The first line is the effects of pharmacological manipulation using agonists or antagonists at both nicotinic and muscarinic receptors (Decker and McGaugh, 1991; Murray and Fibiger, 1985; Mandel and Thal, 1988; Mandel et al., 1989; Drachman and Leavitt, 1974; Drachman, 1982; Flicker et al., 1992; Vanderwolf et al., 1990; Wesnes et al., 1990). Second is the fact that adverse effects of lesioning cholinergic nuclei are ameliorated by intracerebral transplantation of fetal cholinergic cells or genetically modified tissue (Alkon et al., 1991; Dekker et al., 1991; Page et al., 1991; Berger- Sweeney et al., 1994; Dunnett et al., 1985; Gage and Bjorklund, 1986; Nilsson et al., 1987). The third is the fact that deficits in cholinergic cortical innervation and decreases in nicotinic receptors are seen in humans during aging and Alzheimer’s disease (AD) (Perry et al., 1978; Whitehouse et al., 1982; Bartus et al., 1982; Giacobini et al., 1989; Schroder et al., 1995). Results from these investigations are consistent with the concept that cholinergic function is required for learning and memory. A recent article of Winkler et al. (1995) demonstrates that cerebral ACh is not only necessary for cognitive behavior in the rat but its presence and function within the neocortex is also sufficient to improve learning deficits and restore memory in experimental animals following severe damage to the nucleus basalis of Meynert.
Prosocial Television, Preschool Children’s Moral Judgments, and Moral Reasoning: The Role of Social Moral Intuitions and Perspective-Taking:

Children’s prosocial television shows include moral lessons in their narratives, but research suggests that children struggle to comprehend and transfer these lessons to other situations. The social intuitionist model of moral judgment, however, argues that dimensions of morality can be made more salient through environmental exposure. Using data collected from 101 parent-child dyads (children ages 4.5-6.5), we explore if children’s existing moral intuitions about fairness and care may be made salient following exposure to moral lessons in a children’s television show, and if parent presence and mediation aid this process. Results demonstrate that, compared with children in the control group, children who viewed the moral message either alone or with a parent experienced improvements in perspective-taking, which in turn influenced their moral judgments and moral reasoning. Thus, children’s morality can be positively influenced by prosocial television exposure via promoting perspective-taking, fairness, an...
Examining factors influencing food tourist intentions to consume local cuisine

Food tourism is an activity which has grown in popularity. While it encompasses different activities, consuming local cuisine appears to be particularly popular. Yet, there is a lack of research measuring food tourist behavior using advanced social psychology theory. This study used an extended model of goal-directed behavior to understand food tourist desires and intentions to consume local cuisine. Data were collected at six restaurants in the Southeastern USA and 430 responses were obtained. Anticipated positive emotions and self-identity had the strongest influences on desire. Frequency of past behavior had the strongest influence on intentions. Implications are discussed in detail.
Concluding Remarks: LISA Meetings, Past and Present

A short history of how the Library and Information Services in Astronomy (LISA) conference came into existence is given, with some remarks about the character of each meeting. Memorable moments of the conference just held are mentioned. The author’s thoughts on the future of LISA is briefly discussed. 1. Beginning of the LISA Meetings Perhaps a history of how the Library and Information Services in Astronomy (LISA) conferences began will be of interest. As my husband, Thomas Corbin, is an astronomer who spent his career at the U.S. Naval Observatory (USNO), I would sometimes attend conferences with him. In 1982, we attended the IAU General Assembly in Patras, Greece. I had asked if I might make a brief presentation to Commission 5 (Astronomical Data and Documentation) concerning astronomical libraries. The president of the Commission graciously agreed, and I discussed various projects of interest to astronomy libraries. I also suggested that it would be useful to have an international meeting of astronomy librarians, perhaps arranged and sponsored by Commission 5. The group supported the idea of such a meeting, and over the next few years I continued to discuss such a meeting with my colleagues and with Gart Westerhout, then Scientific Director of the U.S. Naval Observatory, also a member of Commission 5. He thought such a meeting was a good idea and agreed to keep the idea in front of Commission 5. My husband and I did not attend the IAU General Assembly in Delhi, India in 1985, but I suggested that Dr. Westerhout discuss the proposed meeting with Commission 5. Robyn Shobbrook, then librarian at the Anglo-Australian Observatory, was also in Delhi and represented astronomy libraries. Dr. Westerhout returned from India and reported that Commission 5 warmly welcomed such a meeting and would ask for financial support from the IAU. He also reported that he had volunteered the USNO to act as host for the conference and volunteered the librarian, myself, to do the planning! I had never been involved with conference planning in any way, but with help from many colleagues, especially Sarah Stevens-Rayburn, Space Telescope Science Institute (STScI), Ellen Bouton, National Radio Astronomy Observatory (NRAO), Adelaide del Frate, Coordinator of NASA libraries, and staff members at the Naval Observatory, we planned the conference.
Neoplastic Transformation Systems — Their Use in Studying Carcinogenesis

The cellular systems to study neoplasia essentially stem from two sources. One is the observation that one can induce alterations in cellular phenotype in a culture of cells infected with tumorigenic DNA viruses (1). The second is the finding of Berwald and Sachs in 1963 (2,3) that early passage Syrian hamster embryo cells exhibited clonal morphology not seen in untreated cultures following exposure to a chemical carcinogen. While the work of Earle and his associates (4) beginning in the nineteen thirties had demonstrated changes in cell cultures treated with carcinogens, it was the protocol and results reported in 1963 (2,3) that provided a means to obtain quantitative and reproducible findings of morphological transformation of mammalian cells induced by chemical carcinogens. Over the past two decades a considerable variety of systems have been described to study neo-plastic transformation. Of these, several have been shown to have value as bioassays for the identification of carcinogens. The properties as well as the advantages and disadvantages of these assays have been reviewed in depth recently along with a presentation of the available data base on tested chemicals (5–9). Table 1 lists these assay types along with some basic characteristics.
Philosophy of Language and Philosophy of Science

For over a hundred years, one of the dominant tendencies in the philosophy of science has been verificationism: that is, the doctrine that to know the meaning of a scientific proposition (or of any proposition, according to most verificationists) is to know what would be evidence for that proposition. Historically, verificationism has been closely connected with positivism: that is, at least originally, the view that all that science really does is to describe regularities in human experience. Taken together, these two views seem close to idealism. However, many twentieth century verificationists have wanted to replace the reference to experience in the older formulations of these doctrines with a reference to “ observable things ” and “ observable properties ”. According to this more recent view, scientific statements about the color of flowers or the eating habits of bears are to be taken at face value as referring to flowers and bears; but scientific statements about such “ unobservables ” as electrons are not to be taken as referring to electrons, but rather as referring to meter readings and the observable results of cloud chamber experiments. It is not surprising that philosophers who took this tack found themselves in a certain degree of sympathy with psychological behaviorism. Just as they wanted to “ reduce ” statements about such unobservables as electrons to statements about “ public observables ” such as meter readings, so they wanted to reduce statements about phenomena which, whatever their private status, were publicly unobservable, such as a person’s sensations or emotions, to statements about such public observables as bodily behaviors.
The Contributions of Conversation Analysis and Interactional Linguistics to a Usage-Based Understanding of Language: Expanding the Transdisciplinary Framework

A key insight of a transdisciplinary perspective on second language acquisition (SLA) as articulated by the Douglas Fir Group (2016) is its usage-based understanding of language. Evidence on the fundamental role that usage plays in shaping individual language knowledge is no doubt compelling. However, while the force of social interaction in shaping language knowledge is acknowledged, missing are specifications of the jointly constructed actions and courses of action comprising social contexts of use. Also missing is a reconsideration of key SLA concepts engendered by a usage-based understanding of language. The intent of this paper is to redress these limitations. First, I summarize the research programs of conversation analysis and interactional linguistics, which take as their central task the specifications of the jointly constructed actions and courses of action comprising social contexts and thus significantly enhance a usage-based understanding of language. Then, arguing that more suitable conceptual tools are needed to better capture current understandings of language knowledge and objects of L2 learning, I offer repertoire, semiotic resources, and register as alternative terms to competence and grammar. I conclude with a proposal for a Conversation Analysis/Interactional Linguistics-based research program for further advancing understandings of SLA and transforming understandings of L2 pedagogy.
Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa-induced sepsis pig model.

In a highly translational acute sepsis model, presented data suggest that jejunal mucosal protein metabolism is diminished in acute sepsis, even if the origin of the sepsis is not located in the gu...
Immune-related adverse events in advanced NSCLC treated with immunotherapy alone or concurrent chemotherapy and immunotherapy.

83Background: Concurrent chemotherapy (CTX) with checkpoint inhibitors (CPI) has become a new standard of care for treatment naive stage IV non-small cell lung cancer (NSCLC). Little is known about...
Consistent principles for particle identification by pulse shape discriminating systems

Identifying particles that interact in materials that exhibit pulse-shape discrimination (PSD) is a statistical classifier problem. The field of statistical classifiers provides a toolkit of elements and principles that PSD can employ and re-use regardless of the detector material and read-out. Journals have published a myriad of PSD papers over the decades featuring useful components and concepts for implementing and/or improving particle identification. This paper categorizes and assembles PSD methods into one consistent taxonomy. Among the essential elements to consider when building a classifier, one encounters features, pre-processed and reduced features, labels, contamination, coverage, the model, the classifier, optimization and performance metrics, training, testing, scoring, performance trade curves, and thresholding.
Investigating uneven recovery of repatriated bobcats (Lynx rufus) in a mined landscape: space use, habitat use and condition in coal country

Abstract Context Bobcats (Lynx rufus) were extirpated from Ohio, USA, during the mid-1800s. Genetic evidence indicates that they recolonised from neighbouring states. Initial re-establishment occurred almost simultaneously in two spatially distinct areas of a coal-mined landscape in the 1980s. Relative population growth was apparently higher in the eastern than in the southern area. Aims Understanding the reasons for the disparity in population dynamics and sustainability is essential for proper bobcat management. It also addresses substantial knowledge gaps in vertebrate carnivore ecology on mined land. We hypothesised that the characteristics of mined land in the eastern Ohio area provided bobcats with greater resources, enabling a more rapid recovery. Methods We trapped bobcats and took body measurements and weights to determine condition indices. We attached GPS radio-collars and used locations to determine annual home-range and core-area sizes, home-range and core-area overlap, and habitat selection using remotely sensed land cover data and mine permit records. We compared factors between the two bobcat population areas. Key results Body condition indices were higher, and home ranges and core areas of males and females were smaller, for eastern Ohio bobcats. Home-range overlap did not differ for any dyad type. Selection of mined land by habitat type differed at the home-range level, with eastern bobcats selecting more mined habitats and southern bobcats showing an opposite tendency. Conclusions An interaction may exist between landscape features of former surface mines and bobcat recovery. Results suggest more favourable habitat conditions in the eastern area, which featured more mined land and more older, less regulated mines, than in the southern area. These conditions may support a higher bobcat reproductive success. Implications The first bobcat harvest season in Ohio is under development by authorities. We recommend the regulation of eastern and southern Ohio as separate bobcat management units; the southern population should remain protected, and the eastern population should be managed conservatively as a source population to further colonise southern Ohio. Our data suggest that surface-mined land can be conducive to the restoration and conservation of species.
Turbulent Heat-Transfer Enhancement in Boundary Layers Exposed to Free-Stream Turbulence

Direct numerical simulations (DNS) are performed to study the effect of free-stream vortical forcing on a thermal turbulent boundary layer. In presence of external perturbations, the heat-transfer rate from the wall is increased relative to the unforced case. An explanation is provided, and starts from the free-stream forcing which enhances the Reynolds stresses inside the boundary layer, and in particular the wall-normal component. As a result, the wall-normal heat flux is also increased, which has the dual effect of distorting the base temperature profile and enhancing the production of scalar variance; both contribute to the increase in the wall heat-transfer rate. In addition, the flow sustains higher thermal fluctuations, even though the free-stream forcing is only vortical, and not thermal. These changes are accompanied by modification of the spectra of the thermal field in the outer region of the boundary layer, where large-scale thermal structures are formed in response to the large-scale velocity motions. In the near-wall region, the thermal structures are modulated by the outer hydrodynamic field and are strengthened relative to the unforced flow.
Physical environment virtualization for human activities recognition

Human activity recognition research relies heavily on extensive datasets to verify and validate performance of activity recognition algorithms. However, obtaining real datasets are expensive and highly time consuming. A physics-based virtual simulation can accelerate the development of context based human activity recognition algorithms and techniques by generating relevant training and testing videos simulating diverse operational scenarios. In this paper, we discuss in detail the requisite capabilities of a virtual environment to aid as a test bed for evaluating and enhancing activity recognition algorithms. To demonstrate the numerous advantages of virtual environment development, a newly developed virtual environment simulation modeling (VESM) environment is presented here to generate calibrated multisource imagery datasets suitable for development and testing of recognition algorithms for context-based human activities. The VESM environment serves as a versatile test bed to generate a vast amount of realistic data for training and testing of sensor processing algorithms. To demonstrate the effectiveness of VESM environment, we present various simulated scenarios and processed results to infer proper semantic annotations from the high fidelity imagery data for human-vehicle activity recognition under different operational contexts.
Provocations of Virtue: Rhetoric, Ethics, and the Teaching of Writing: John Duffy. Provocations of Virtue: Rhetoric, Ethics, and the Teaching of Writing. Logan, UT: Utah State University Press, 2019. 172 pages. $22.95 paperback.

“The term virtue,” John Duffy notes wryly in his recent book, “is not exactly trending”—yet perhaps it should be (14). Virtue, as Duffy, John Gallagher, and Steve Holmes suggest in the introduction...
Phase field disconnections: A continuum method for disconnection-mediated grain boundary motion

Abstract Grain boundary (GB) migration is a key mechanism underlying such phenomena as recrystallization, solidification, and severe plastic deformation. Mounting evidence suggests that the motion of many grain boundaries is mediated through disconnections. Disconnections have been observed and characterized in experiment and atomistic simulation, but have yet to be motivated mechanistically. This work presents a continuum phase field model in which disconnections arise naturally as the result of GB energy nonconvexity, the minimum dissipation potential model for GB migration, and the prescribed coupling factor. The model is applied to a Σ13 copper symmetric tilt grain boundary, and disconnection-mediated migration is observed.
Bone Interface Modulates Drug Resistance in Breast Cancer Bone Metastasis

Metastatic breast cancer cells on arriving at bone site interact with the bone cells to influence their growth, proliferation, and chemoresistance. There are currently no effective therapeutics available in the clinic for bone metastases. Many existing anti-cancer therapeutics are ineffective at the metastatic bone site due to a lack of accurate models of breast cancer bone metastasis for drug screening. Here, we report the development of an effective in vitro model using osteogenically differentiated human mesenchymal stem cells (MSCs) and human breast cancer cells on 3D nanoclay scaffolds as a testbed for screening drugs. Our results demonstrate that breast cancer cells grown in 3D bone-mimetic scaffolds exhibited altered physiological and biochemical properties, including tumoroids formation, elevated levels of cytokine such as IL-6, and its downstream effector-mediated inhibition of apoptosis and upregulation of multidrug transporters proteins, leading to drug resistance against paclitaxel. Most importantly, Signal Transducer and Activator of Transcription 3 (STAT3), a potential biomarker for chemoresistance in many cancers, was activated in the 3D breast cancer bone metastasis model. Thus, our data suggest that 3D bone-mimetic nanoclay scaffolds-based in vitro tumor model is a promising testbed for screening new therapeutics for breast cancer bone metastasis where bone interface governs drug resistance in breast cancer cells.
A Sign of Trust? The value of source attribution in accolade claims

Organizations that have received an accolade or honor often share this information with current or prospective customers, either in a digital (i.e., on their website, social media, etc.) or physical (i.e., on-premise signs, outdoor signs, etc.) format. When publicizing their achievement, marketers must make decisions related to source attribution—that is, how much detail to provide and how prominently (if at all) to mention the thirdparty entity that bestowed the accolade upon them. This is an important question, particularly with respect to physical signs where informational complexity is often detrimental and visual clarity is paramount. In this research, I examine whether source attribution in signage materially affects consumer evaluations and behavioral intentions. Across three studies, I find converging evidence that source attribution in accolade claims does in fact bolster evaluations and behavioral intentions, even in the context of physical signage when consumers are likely to be engaged in heuristic processing. Furthermore, I provide evidence that these more positive judgments arise because attribution increases perceived credibility of the organization receiving the accolade.
Investigating the impact of driving automation systems on distracted driving behaviors.

Abstract Driving automation systems (e.g., SAE Level 2) ultimately aim to enhance the comfort and safety of drivers. At present, these systems are able to control some portions of the driving task (e.g., braking, steering) for extended time periods, giving drivers the opportunity to disengage from the responsibilities associated with driving. In this study, data derived from two naturalistic driving studies involving automation-equipped vehicles were analyzed to evaluate driver behaviors with respect to driving automation system use, specifically distraction-related factors (i.e., secondary task engagement, eye-glance behavior, and drowsiness). The results indicate that when drivers had prior experience using driving automation systems, they were almost two times as likely to participate in distracted driving behaviors when the systems were active than during manual driving. Drivers with less experience and familiarity with driving automation systems were less likely to drive distracted when the systems were active; however, these drivers tended to be somewhat drowsy when driving with systems activated. The results provide important insights into different operational phases of driving automation system use (i.e., learning/unfamiliar vs experienced users), whereby experience results in overtrust and overreliance on the advanced technologies, which subsequently may negate some of the safety benefits of these systems. Thus, while the safety benefits of driving automation systems are evident, it is imperative to better understand the impact these advanced technologies may have on driver behavior and performance in order to evaluate and address any unintended consequences associated with system use.
Comprehensive Analysis of Products and the Development of a Quantitative Mechanism for the OH Radical-Initiated Oxidation of 1-Alkenes in the Presence of NOx.

The reactions of 1-tetradecene and 1-pentadecene, the C14 and C15 linear 1-alkenes, with OH radicals in the presence of NOx were investigated in a series of environmental chamber experiments. Particle-phase β-hydroxynitrates, dihydroxynitrates, dihydroxycarbonyls, and 1,4-hydroxynitrates and gas-phase aldehydes were sampled and then identified and quantified using a suite of offline analytical techniques that included derivatization, gas and liquid chromatography, and multiple types of mass spectrometry. Measured molar yields of products formed by OH radical addition to the C═C double bond, including β-hydroxynitrates, dihydroxynitrates, dihydroxycarbonyls (which have not been previously directly quantified with high accuracy), and aldehydes were 0.125 ± 0.01, 0.048 ± 0.005, 0.240 ± 0.04, and 0.268 ± 0.03 (0.264 ± 0.02 and 0.271 ± 0.04 for the formaldehyde and tridecanal/tetradecanal co-products of β-hydroxyalkoxy radical decomposition), respectively. These values give a total molar yield of 0.681 ± 0.05, which agrees very well with the results of kinetics measurements that indicate that the fraction of reaction that occurs by OH radical addition is 0.70. The yields were used to calculate branching ratios for all OH radical addition pathways, including a value of 0.18 for the formation of dihydroxynitrates from the reaction of dihydroxyperoxy radicals with NO and values of 0.47 and 0.53 for β-hydroxyalkoxy radical decomposition and isomerization. The results were used with literature data on the yields of aldehydes measured for similar reactions of smaller alkenes, a model for the effect of carbon number on branching ratios for organic nitrate formation, and a mechanism for H atom abstraction derived from studies of linear alkanes to achieve a complete, quantitative gas-phase reaction mechanism for 1-alkenes. The results should also be useful for constructing mechanisms for more complex reactions of volatile organic compounds.
Recurrent Renal Allograft Torsion After Simultaneous Kidney and Pancreas Transplantation: Is it Still Possible to Salvage the Graft? A Case Report

ABSTRACT Background Kidney allograft torsion (KAT) is defined as a rotation of the renal allograft around its vascular pedicle. It is a rare complication with high rate of graft loss. The nonspecific presentation and inability to provide a definitive diagnosis by imaging, mainly in cases of partial torsion, often delay the diagnosis and treatment. We report a case of recurrent complete torsion of the renal allograft after simultaneous kidney and pancreas transplantation, requiring 2 emergency exploratory laparotomies. Case report A 38-year-old woman with a history of intraperitoneal simultaneous kidney and pancreas transplantation underwent 2 separate emergency exploratory laparotomies secondary to complete renal allograft torsion, respectively, 7 and 11 months after the transplant. In both episodes, no adhesions were encountered. During the first operation, nephropexy was performed. During the second operation, an abdominal wall mesh was placed and fixed to the abdominal wall. Acute kidney injury related to KAT recovered in both occasions with a creatinine of 1.3 mg/dL at 4 months follow-up. Conclusions Renal torsion always should be suspected in intraperitoneally placed kidneys presenting with nonspecific symptoms, abdominal pain, oliguria, and worsening kidney function. Surgical exploration should be considered to salvage the renal graft. This case illustrates the reversibility of a severe injury related to this vascular complication with an adequate return to baseline kidney function even when diagnosis and surgical treatment of KAT might be delayed secondary to its misleading clinical presentation.
Intensive symptom control of opioid-refractory dyspnea in congestive heart failure: Role of milrinone in the palliative care unit.

Objective We describe an exemplary case of congestive heart failure (CHF) symptoms controlled with milrinone. We also analyze the benefits and risks of milrinone administration in an unmonitored setting. Method We describe the case of a patient with refractory leukemia and end-stage CHF who developed severe dyspnea after discontinuation of milrinone. At that point, despite starting opioids, she had been severely dyspneic and anxious, requiring admission to the palliative care unit (PCU) for symptom control. After negotiation with hospital administrators, milrinone was administered in an unmonitored setting such as the PCU. A multidisciplinary team approach was also provided. Results Milrinone produced a dramatic improvement in the patient's symptom scores and performance status. The patient was eventually discharged to home hospice on a milrinone infusion with excellent symptom control. Significance of results This case suggests that milrinone may be of benefit for short-term inpatient administration for dyspnea management, even in unmonitored settings and consequently during hospice in do-not-resuscitate (DNR) patients. This strategy may reduce costs and readmissions to the hospital related to end-stage CHF.
Transparency induced by coupling of intersubband plasmons in a quantum well

Coupling of intersubband plasmons associated with two cascading transitions in a quantum well has been studied. It is shown that the coupling can lead to the disappearance of the lower resonance amidst an anti‐crossing behavior. Such spectral anomalies are of collective and resonant nature and provide the first example of Coulomb interaction induced transparency. The results from a microscopic theory are confirmed by an analytical model.
Simulations and Parameter Variation Studies of Heavy Gas Dispersion Using the Slab Model — Condensed

We are employing the SLAB model in ongoing studies of the atmo-spheric dispersion of heavy gases. SLAB computer simulations of four of the Burro series large-scale 40-m3 liquefied natural gas (LNG) spill experiments at China Lake, California [1] have been successful in predicting distances to the lower flammability limit (LFL) [2]. We have used this model in simulations of three of the Coyote series of experiments [3] as well as in parameter variation and sensitivity studies [4] and improved simulations of some of the Burro tests. The parameters studied include source rate, wind speed, atmospheric stability, type of source gas, and source duration, as well as the parameters important to certain physics submodels.