cssi/SciSciGPT-SciSciNet huggingface dataset:
Global Rates and Prevalence of Urogenital Mycoplasmosis: Assembly of a Dataset from Peer-Reviewed Literature *

Rates of urogenital mycoplasmosis associated with Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum have been reported numerous times, and frequently show a wide range of findings. Differing diagnostic techniques, population targeting, temporal and spatial data collection, and coincident infections make the conclusions from these analyses difficult to compare. We generated a single data set including the infection rate, geographic location, year, study population, diagnostic method, and clinical signs for these organisms by performing literature searches with the species names and compiling the findings. Studies focusing on basic research or reporting clinical surveys where these criteria were not reported were excluded. A statistical analysis of the dataset parameters found that: diagnostic method does not significantly correlate with positive specimen rate but does correlate with the year of publication, and the number of publications correlated significantly with year, indicating that this topic is of growing interest. Further analysis indicated that Ureaplasma species infection rate is significantly higher in pregnant women across all studies. Associations with distinct clinical presentation could not be made on datasets assembled across studies due to the number of confounding variables presented in each. The generated data set represents a large amount of temporal, geographic, and clinical data that can be utilized in future communications.
A World of Goods

Contemporary moral philosophers often divide moral theories into three mair types: consequentialism (of which utilitarianism is the most famous and popular example), deontology (closely associated with the ethics of Immanuel Kant), and virtue ethics (a more amorphous category, associated with Aristotle's ethical writings). In Finite and Infinite Goods, Robert Merrihew Adams presents an ethical framework that fits none of these categories. It is founded on a fundamental commitment to the idea that there is a Transcendent Good, to be understood philosophically in realist, non-naturalist terms. As I prefer to put it, Adams starts with a conviction that we live in a World of Goods. In developing and elaborating a perspective on ethics built around this conviction, Adams shows his appreciation of the traditions to which his ethical framework is an alternative, his sensitivity to human psychology, and his embrace of a diversity of values. The result is one of the most original and profound books on ethics I have seen in decades. Because his framework is theistic, and because Adams is known to have a divine command view of obligation, nonreligious philosophers might assume that it is not worth their time to read so long and tightly argued a book as this. Perhaps the avowed links of his ethical views to those of Plato will not do much for his popularity either. But it would be a great mistake for serious moral philosophers to pass this book by.
Lateral tire force estimation with unknown input observer

This paper presents the development of a lateral tire force estimation algorithm. Rather than using highly nonlinear tire-road friction models, the unknown input observer combined with the yaw rate measurement is proposed to estimate the yaw moment generated by the lateral tire forces with respect to those selected reference points. Two types of unknown input observers are designed for this purpose in the study. Finally, the estimation of the sum of the lateral tire forces of two front wheels and two rear wheels are obtained from these estimated yaw moment signals through a simplified kinematic model.Copyright © 2012 by ASME and General Motors
Sparse random distribution of noninteracting small chiral spheres in a chiral host medium

ABSTRACT Considered here are the effective medium properties of a chiral composite made of adilute concentration of small non-interacting chiral spheres, randomly suspended in a chiral host medium. Volume integral equations to determine the scattering characteristics of an inhomogeneous chiral scatterer are given. These equations are utilized to derive the electromagnetic polarizabilities of a small, homogeneous, chiral sphere embedded in a homogeneous chiral host medium. Finally, from the polarizabilities, the effective properties of the chiral-chiral composite are obtained.1. INTRODUCTIONThe discovery of optical activity in substances of organic origin in the early part of thelast century had several major consequences. First, the phenomenon was extensively utilized to characterize organic molecules; second, it was responsible in part for theelucidation of the true nature of light; and finally, it led to quantum-mechanical investigations of atoms and molecules. But, only recently has considerable interest been
Genomic Data in the Electronic Medical Record Perspectives From a Biobank Community Advisory Board

A proof of principle pharmacogenomic translational study was used as a case example to explore Biobank Community Advisory Board (CAB) member views about placing genomic information into the medical record and to establish how CAB input could affect research design. CAB members expressed enthusiasm for the potential benefit of the research discussed, yet voiced concerns regarding the recruitment and consent materials. They discussed the value of genomic research and its clinical utility; the risk of genetic discrimination; and personal ownership of genomic data. Members distinguished between indirect benefits to future generations and individual risk to research participants. Feedback was used to revise the recruitment and consent materials. Results highlight tensions reported between the public’s support for genomic research and concerns with genomic information in the medical record and its use in medical decision-making.
A preliminary watershed scale soil quality assessment in north central Iowa, USA

Abstract Soil quality assessment has been recognized as an important step toward understanding the long-term effects of conservation practices within agricultural watersheds. Our objective was to assess soil quality within the South Fork watershed of the Iowa River using various indicators and assessment approaches. Soil samples were collected during 2003 and 2004 from 29 areas of 32 ha (80 acres) each along two transects traversing the watershed. Soil pH, Mehlich III extractable P, K, Ca and Mg, electrical conductivity (EC), total organic carbon (TOC), and total N (TN) were measured. The Soil Management Assessment Framework (SMAF) was used to compute a soil quality index (SQI), while soil loss, the soil tillage intensity rating (STIR), N-leaching potential, and soil conditioning index (SCI) were determined for each sampling area using the 2003 version of the Revised Soil Loss Equation (RUSLE2). Overall, there were no soil fertility limitations within the watershed based on an average pH of 6.96 and extractable P and K levels of 36 and 162 mg kg −1 , respectively. Soil loss, STIR, N-leaching, and SCI averaged 1.13 Mg ha −1 , 68, 3, and 0.4, respectively. The SMAF analysis indicated soils within the watershed were functioning at 87% of their full potential. The lowest indicator score was associated with TOC (0.60) because the average value was only 28.4 g kg −1 . The SCI and SQI indices were positively correlated although since it used measured data, the SMAF appears to provide more information about the effects of management practices within the watershed. Soils in upper landscape positions had lower TOC and C:N ratios indicating an increased risks for both erosion and for nitrate leaching. Management of soils on hilltops may be the most effective way to minimize N and P losses within the watershed.
Phencyclidine-like discriminative stimulus properties of opioids in the squirrel monkey

The opioids SKF 10047, dl-cyclazocine, and dextrorphan have been shown to have phencyclidine (PCP)-like discriminative stimulus properties in the rat. In order to extend the generality of this observation, the stimulus effects of these and other opioids were evaluated in squirrel monkeys trained to discriminate between IM injections of saline and 0.25 mg/kg of PCP in a two-choice discrete-trial avoidance paradigm. Stimulus control of behavior was characterized by the reliable completion of at least 22 trials of a 25-trial session on the appropriate choice lever after an injection of saline or PCP. In tests of stimulus generalization, SKF 10047, d-cyclazocine, dextrorphan, normetazocine, dl-cyclazocine, l-cyclazocine, and dextromethorphan occasioned dose-related increases in PCP-appropriate responding. The first four of these compounds and, under some conditions, l- and dl-cyclazocine, produced stimulus control of behavior comparable to that produced by the PCP training dose. Six other opioids occasioned responding only on the saline-appropriate lever: ethylketocyclazocine, ketocyclazocine, levorphanol, levallorphan, pentazocine, naltrexone. Naltrexone (1.0 or 4.0 mg/kg) attenuated slightly the PCP-like stimulus effects of SKF 10047 and dextrorphan, but increased PCP-appropriate responding with l- and dl-cyclazocine and levorphanol by enabling higher doses of these drugs to be tested without disruption of responding. The PCP-like stimulus effects of certain opioids appear to be mediated at neuronal substrates acted upon by PCP rather than at sites typically associated with opiate activity. These neuronal sites of action common to opioids and PCP may correspond to the sigma “opiate” receptor.
IN VITRO ANALYSIS OF FUROSEMIDE DISPOSITION DURING NEONATAL EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) † 456

IN VITRO ANALYSIS OF FUROSEMIDE DISPOSITION DURING NEONATAL EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) † 456
A simple proof of the LeChatelier-Samuelson principle and the theory of cost and production

Abstract We provide a simple proof of a version of the so-called strong LeChatelier-Samuelson principle particularly suitable for the application to the theory of cost and production. We will illustrate its usefulness and fundamental nature in the case of the classical theory of cost and production.
Differential predation by Coleomegilla maculata on Colorado potato beetle strains that vary in growth on tomato

This study tests the hypothesis that the generalist predator Coleomegilla maculata DeGeer causes differential mortality of Colorado potato beetle, Leptinotarsa decemlineata (Say), larvae differing in their degree of genetic adaptation to tomato (Lycopersicon esculentum Mill.) as a host plant. Results of a series of laboratory experiments demonstrate that adult C. maculata can cause higher mortality to nonadapted than adapted Colorado potato beetle larvae. The extent of differential mortality caused by C. maculata depended on age of potato beetle larvae; presence of potato beetle eggs; whether or not the predator had a choice among prey items; and, in choice situations, the ratio of adapted to nonadapted potato beetle larvae. Although adult C. maculata have the potential to prey differentially on tomato-adapted and nonadapted Colorado potato beetle larvae in mixed populations, the magnitude of differential predation in a natural setting could be highly variable.
Influence of jealousy on male and female college daters

Jealousy within a relationship tends to diminish the relationship and might ultimately lead to its loss. The present study was concerned with the influence of jealousy on male and female college daters. It centered on the effect of jealousy on the jealous dating partner. It focused on how the partner felt as he or she was experiencing the jealousy toward the other person. The results indicated the effect of jealousy on the male and female dating partners tended to be associated with feelings of loss of affection, rejection, insecurity, anxiety, semantics, insincerity, inadequacy, low self-esteem, suspicion, and rivalry.
Raman spectroscopy for the detection of cancers and precancers

Optical spectroscopy has been extensively studied as a potential in vivo diagnostic tool that can provide information about both the chemical and morphologic structure of tissue in near real time. Most in vivo studies have concentrated on elastic scattering and fluorescence spectroscopies since these signals can be obtained with a good signal-to-noise ratio quickly. However, Raman spectroscopy, an inelastic scattering process, provides a wealth of spectrally narrow features that can be related to the specific molecular structure of the sample. Because of these advantages, Raman spectroscopy has been used to study static and dynamic properties of biologically important molecules in solution, in single living cells, in cell cultures, and more recently, in tissues. This article reviews recent developments in the attempt to develop diagnostic techniques for precancers and cancers, based on Raman spectroscopy. The article surveys important transformations that occur as tissues progress from normal to precancer and cancerous stages. We briefly review the extensive literature that summarizes the features and interpretation of Raman spectra of these molecules in solution, and in progressively more complex biological systems. Finally, spectra obtained from intact tissues are comprehensively reviewed and discussed in terms of the molecular and microscopic literature to develop a framework for analyzing Raman signals to yield information about the molecular changes that occur with neoplasia. The article concludes with our perspective on the potential role of Raman spectroscopy in diagnosing precancer and cancerous tissues.
The Effects of a Gonadotropin-Releasing Hormone Antagonist on Androgen-Binding Protein Distribution and Other Parameters in the Adult Male Rat*

The effects of gonadotropins and gonadal steroids on androgen-binding protein (ABP) production and its distribution among the epididymis, seminiferous tubule fluid (STF), testicular interstitial fluid (TIF), and blood were studied in 300-g adult male Sprague-Dawley rats. The rats either received no treatment or their pituitary function was suppressed by administration of the GnRH antagonist [AcD2Nal,D4ClDPhe2,D3Pal3,Arg5,DGlu6 (AA),D-Ala10]LHRH (antagonist). Other groups of rats were treated with hCG, FSH, FSH plus hCG, testosterone, or estradiol, alone or together with antagonist. Treatment was conducted for 30 days, after which time, ABP was detected by its ability to bind [3H]5 alpha-dihydrotestosterone. Transport of ABP from the testis to the epididymis was inhibited by antagonist administration. Simultaneous treatment with antagonist and hCG, or antagonist and hCG plus FSH prevented antagonist-induced inhibition of ABP transport. Neither FSH, testosterone, nor estradiol alone was effective in this process. Inhibition of ABP transport to the epididymis was accompanied by its accumulation within the testis. Treatment with antagonist and FSH resulted in a 4.5-fold increase in the concentration of ABP in TIF, but had little effect on the amount of ABP in STF, indicating selective secretion of ABP from the basal surface of the Sertoli cells. Treatment with antagonist alone, antagonist together with testosterone or estradiol, or estradiol alone resulted in increased concentrations of ABP in both TIF and STF, but the increase in TIF was proportionately greater. Treatment with hCG or FSH plus hCG alone or with antagonist not only facilitated ABP transport to the epididymis, but also increased TIF levels of ABP above control values. The former treatment resulted in increased concentrations of testosterone in TIF, but not in STF. Both treatments resulted in testosterone levels in both compartments that were higher than those in animals treated with antagonist alone. No treatment had a statistically significant effect on blood levels of ABP. About 50% of ABP synthesis appears to be constitutive, i.e. is not regulated by hormones. Although ABP production continues in the presence of antagonist, its transport to the epididymis is halted, indicating that epididymal transport of ABP is a hormone-dependent process. It is likely that elevated intratesticular levels of testosterone or FSH and testosterone acting in concert regulate epididymal transport of ABP.
Diphenylbarbituric Acid: Its Effects on Neuromuscular and Spinal Cord Function in the Cat

In studies of neuromuscular function in the cat soleus muscle, diphenylbarbituric acid (DPB; 10-80 mg/kg i.v.) depressed both the degree and the duration of posttetanic potentiation (PTP) in a dose-dependent manner. At doses of greater than 20 mg/kg, twitch strength was increased in both indirectly stimulated and directly stimulated chronically denervated preparations, indicating a direct effect of DPB on muscle. In the spinal cord, DPB (10-60 mg/kg) depressed both monosynaptic (2N) and polysynaptic discharges, with flexor and extensor reflexes being similarly affected. In addition, DPB was not selective for isolated 2N as compared with posttetanically potentiated monosynaptic responses. Thus, in its actions on neuromuscular function DPB resembles phenytoin; in the spinal cord the drug resembles phenobarbital. The data suggest that the capacity of a drug to curb high-frequency repetitive discharges is more important than curbing recruitment as exhibited by PTP of the 2N reflex.
A sensitive method to detect defined peptide among those eluted from murine MHC class II molecules.

Abstract We developed a sensitive competitive inhibition radioimmunoassay able to trace pmoles of a defined peptide eluted from major histocompatibility complex (MHC) class II molecules that were subsequently fractionated by RP-HPLC. In this assay we used a model synthetic peptide corresponding to amino acid residues 110–120 from the hemagglutinin (HA) of PR8 influenza virus, and affinity purified rabbit antibodies specific for this peptide. The HA110–120 peptide binds to I-E d class II molecules on the surface of APCs and is recognized by specific CD4 + T helper cells. 2PK3 B lymphoma cells (H-2 d ) were pulsed with HA110–120 peptide or PR8 virus, lysed, the MHC class II molecules extracted, and bound peptides eluted. After separation by RP-HPLC, the fractions were tested for inhibition of the binding of rabbit anti-HA110–120 antibodies to peptide coated microtiter plates. A significant inhibitory activity was observed with one peak when the cells were pulsed with HA110–120 peptide and two peaks when pulsed with PR8 virus. The inhibitory activity was correlated with the presence of HA110–120 peptide as demonstrated by peptide sequencing. The assay is reproducible and sensitive to 1 pmol of antigenic peptide. This assay can be useful to identify microbial peptides with defined structure and antigenicity among the multiple peptides bound to class II molecules.
Receptor for advanced glycation endproducts (RAGE) and the complications of diabetes.

Receptor for Advanced Glycation Endproducts (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface molecules with a diverse repertoire of ligands. These ligands include products of nonenzymatic glycation, the Advanced Glycation Endproducts (AGEs, enriched in the diabetic milieu), members of the S100/calgranulin family of proinflammatory mediators, β-sheet fibrillar structures (characteristic of amyloid) and amphoterin (present at high levels in the tumor bed). Ligation of RAGE by its ligands upregulates expression of the receptor and triggers an ascending spiral of cellular perturbation due to sustained RAGE-mediated cellular activation. For example, in the setting of diabetes, a vascular environment rich in AGEs and S100/calgranulins accelerates atherogenesis in murine models, and this can be blocked by intercepting the interaction of ligands with RAGE. While RAGE is certainly not the cause of diabetes, it functions as a progression factor driving cellular dysfunction underlying the development of diabetic complications as the microenvironment becomes enriched in its ligands. Though further studies will be required to determine the importance of RAGE-mediated cellular activation to human chronic diseases, it represents a novel receptor-ligand system potentially impacting on a range of pathophysiologic conditions.
Different expression patterns of p27KIP1 and p57KIP2 proteins in benign and malignant melanocytic neoplasms and in cultured human melanocytes

Background The p27(KIP1) and p57(KIP2) proteins belong to the CIP/KIP family of cyclin-dependent kinase inhibitors involved in the growth arrest and cellular senescence. High levels of p27(KIP1) unexpectedly have been detected in invasive malignant melanomas (MM), whereas the role of p57(KIP2) in melanocytic lesions is unknown. We therefore chose to study the expression of p27(KIP1) and p57(KIP2) in melanocytic neoplasms. Design The expression of p27(KIP1) and p57(KIP2) were examined by immunohistochemistry in 40 melanocytic neoplasms and by Western blot analysis in cultured human melanocytes. Results Expression of both nuclear p27(KIP1) and p57(KIP2) (> 10% of cells with nuclear labeling) was observed in most cases with non-proliferating melanocytes (8/10, benign nevi and 9/10 DN, dysplastic nevi), but in only a few cases containing proliferating melanocytes (3/11 RN, recurrent nevi and 2/9 MM, melanoma) (p Conclusion The difference in expression patterns of p27(KIP1) and p57(KIP2) in proliferating and senescent melanocytes suggests the interplay between these proteins may play a functional role in melanocytic tumorigenesis.
Real-time orthogonal mode scanning of the heart. I. System design.

A necessary precursor to real-time three-dimensional echocardiographic imaging is the ability to obtain multiple planes of acoustic data simultaneously. A new ultrasound imaging technique facilitates the display of two real-time orthogonal B-mode images (O-mode). The O-mode technique uses a novel two-dimensional transducer and system processor to interrogate the two perpendicular planes simultaneously, yielding sector arcs that share one origin. It permits simultaneous display of two sector arcs on a single monitor either side by side or in a two-dimensional projection designed to convey the three-dimensional nature of the acoustic data. Clinical results from the first 50 patients undergoing 0-mode evaluation indicate that image quality in the two simultaneously obtained planes is equal to that of a single plane when the system is operating in its conventional format. These data confirm the feasibility of real-time multiplane imaging. The system design offers the potential for the future addition of more simultaneous planes and, thus, the possibility of real-time three-dimensional ultrasound imaging.
Planar sliding with dry friction Part 1. Limit surface and moment function

Abstract We present two geometric descriptions of the net frictional force and moment between a rigid body and a planar surface on which it slides. The limit surface, from classical plasticity theory, is the surface in load space which bounds the set of all possible frictional forces and moments that can be sustained by the frictional interface. Zhukovskii's moment function (N.E. Zhukovskii, Collected Works, Vol. 1, Gostekhizdat, Moscow, 1948, pp. 339–354) is the net frictional moment about the body's instantaneous center of rotation as a function of its location. Both of these descriptions implicitly contain the full relation between slip motion and frictional load. While Zhukovskii's moment function applies only to ordinary isotropic Coulomb friction, the limit surface applies to a wider class of friction laws that includes, for example, contact mediated by massless rigid wheels. Both the limit surface and the moment function can be used to deduce results concerning the motion of sliding rigid bodies.
System for interactive management of aerial imaging campaigns

We present a system to enable real time management of interchangeable imaging platforms aboard commodity unmanned aerial vehicles (UAVs) to improve interactivity during aerial imaging campaigns. We argue that this improvement in interactivity enables powerful immediate-mode inspection by the ground operator, and implements a more intuitive, flexible, and ultimately useful control interface to aerial imaging systems.
MIS research directions: a survey of researchers' views

Several studies have addressed important issues for MIS research, but until now no empirical studies have been conducted to assess how MIS researchers themselves view the relatively new field. This survey of 397 MIS researchers revealed preferences for research methods and current areas of concentration, current studies being conducted, publication history, and other factors of interest. It found the subjects' assessment of the quality of MIS research relatively low and that they feel there is an over-emphasis on transient topics, rather than on topics of lasting significance. There is continuing evidence of fragmentation in the field. Few MIS researchers appear to rely on research frameworks. However, there is overall optimism that the quality of MIS research has been improving, and will continue to improve in the future. Implications for the future of MIS research are then discussed.
A Comparison of General and Specific Instructions to Promote Task Engagement and Completion by a Young Man with Asperger Syndrome

Previous research has suggested that the topography of instructions (general vs. specific) may influence the likelihood that young children comply with instructions. The purpose of the current study was to compare the rates of task completion of a young man diagnosed with Asperger syndrome when provided with general and specific instructions pertaining to the task. The results showed that specific instructions occasioned higher levels of task completion, even when no differential reinforcement contingencies were in place.
Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies

Summary Of the twenty-three employees at a pharmaceutical plant manufacturing a new product containing papain, twelve had respiratory symptoms of cough, wheezing, dyspnoea, or chest paint. Most were studied with in-depth interviews by a doctor, extensive pulmonary function tests, and imnunoserological tests for IgE and precipitating antibodies specific for papain, as well as total IgE levels and IgE antibodies to common natural allergens. There were significant correlates (all P values <0.05) between the presence of specific IgE antibodies to papain and decreases of FEV1, FEF75–85, RV, and response to bronchodilators as percentage change from baseline for all spirographic flow rates. Atopic workers developed pulmonary symptoms and antipapain antibodies significantly sooner after papain exposure than did the others. Duration of exposure had no effect on symptomatology, pulmonary function, or immunological response. However, those judged to have the greatest amount of dust exposure per work-day had significantly more pulmonary symptoms (P < 0.005). Papain produced lung diseases by acting as an inhalant allergen rather than a proteolytic enzyme, Papain is a potent sensitizer in humans for the production of respiratory disease. The pulmonary reactions, based on physiological data, seem to involve small airways, alveolar, and interstitial lung tissue in an inflammatory rather than destructive manner, and thus resemble bronchitis and interstitial lung disease rather than pulmonary emphysema or typical bronchial asthma.
Reindeer dairying in the Soviet Union

Reindeer milk is used by native peoples throughout the Soviet North. This article describes how different groups use, or have in the past used, the milk in raw and processed form. After summarizing the properties of reindeer milk, it outlines a neglected chapter in the history of domesticated animals: the attempt in the 1930s to set up a commercial reindeer dairy industry in the USSR. Lastly, it analyzes the decline of reindeer milking among peoples of the Soviet north in this century.
Scenarios, Real Options and Integrated Risk Management

Abstract In the 1970s, scenario planning gained prominence as a strategic management tool. Scenario planning encourages managers to envision plausible future states of the world and consider how to take advantage of opportunities and avoid potential threats. In the last decade, finance researchers have developed real option analysis as a way to value investments under uncertainty. Scenario planning and real option analysis have complementary strengths and weaknesses as tools for managers making strategic investment decisions under uncertainty. We combine these two approaches in an integrated risk management process. This process involves scenario development, exposure identification, formulating risk management responses, and implementation steps. We advocate a corporate-level perspective on managing risk that takes into consideration the full range of exposures across a firm’s portfolio of businesses. In contrast with the predominant emphasis on quantitative analysis in the real option literature, this study illustrates qualitative assessment of real options.
Antioxidant Protection of Bulk Fish Oils by Dispersed Sugars and Polyhydric Alcohols

Selected sugars (fructose, sucrose, or raffinose) and polyhydric alcohols (sorbitol or mannitol) were equilibrated directly with bulk fish oil (10% by weight, excess) and exposed to fluorescent lighting (2550 Lx) for 24 h at 5 °C. Data for room temperature-equilibrated samples revealed that polyols functioned as antioxidants in fish oil. Increased times and temperatures of equilibration (to 90−110 °C, 1−2 mmHg, to 2 h) greatly enhanced the antioxidant activity of polyols in fish oil exposed to light. Under accelerated oxidation conditions (60 °C) in the dark, dispersed sorbitol in bulk fish oil greatly suppressed the peroxide value, primarily by chelating transition metals, while fructose showed a limited antioxidant activity. Sugars with a lower molecular weight and smaller numbers of equatorial OH groups exhibited a higher rate of permeation of sugars into fish oil triacylglycerols and hence rendered greater antioxidant activities. The treatment of bulk fish oils with polyols and then using the oils in ...
Triggering of the Alaskan Earthquake of March 28, 1964, and Major Aftershocks by Low Ocean Tide Loads

Triggering of the Alaskan Earthquake of March 28, 1964, and Major Aftershocks by Low Ocean Tide Loads
Nonfuming Carbonaceous Mix For Constructing Seams and Linings Of Metallurgical Vessels

A carbonaceous seam mix applicable at room temperature was developed for the seams between carbon blocks of Hall smelting cell bottoms. It consists of calcined anthracite, coke-oven pitch, and a small amount of solvent. When applied at temperatures below 60°C, the evolution of fumes is sharply reduced, compared with hot mixes used previously. Three other applications for the mix in metallurgical vessels have since been developed: monolithic lining for Hall smelting cells, lining for the ferrosilicon ladles in the Magnetherm Process for producing magnesium, and for supporting the graphite electrodes in Acheson furnaces for silicon carbide manufacture.
Stochastic modeling of flow and transport in deep-well injection disposal systems

Abstract The migration of deep-well injected waste in heterogeneous confining layers is evaluated using numerical simulation. Of primary concern is the migration potential through permeable sand paths between less permeable shale. The configuration of the predominantly shale confining layers was defined by Monte Carlo techniques assuming a binary random structure composed of pure sand and pure shale. Three-dimensional flow simulations using Modflow , a finite difference model, indicated that essentially continuous sand paths and unacceptably rapid transport might exist through confining layers with an average shale fractions of less than about 0.65 and that two and three dimensional flow simulations were essentially equivalent for high (>0.6-0.7) or low (
Energetics of the intrinsic foot muscles in plantar fasciitis

Intrinsic foot muscles and the plantar fascia provide mechanical support for the medial longitudinal arch in gait [1]. In an injury to the plantar fascia (i.e. plantar fasciitis), there may be an increase in load on the intrinsic foot muscles resulting in increased metabolic demand. Phosphorus magnetic resonance spectroscopy (31P MRS) has shown that the ratio of inorganic phosphate to phosphocreatine ([Pi]/[PCr]) within a muscle increases proportionately with muscle work at low to moderate levels [2]. The purpose of this study was to determine whether walking elicits a relatively higher increase in activity of the intrinsic foot muscles of feet with plantar fasciitis relative to healthy feet.
DYNAMICS OF THERMAL MOTIONS WITHIN A LARGE CATALYTIC RNA INVESTIGATED BY CROSS-LINKING WITH THIOL-DISULFIDE INTERCHANGE

Conformational dynamics have been studied in proteins, but the extent of thermal motion within large compact RNA molecules, including ribozymes, has not been systematically explored. Methods are de...
Application of a control‐law nonlinearity measure to the chemical reactor analysis

The optimal control structure has been introduced as a design tool to measure the control-law nonlinearity of a given process design. In this context, control-law nonlinearity is the optimal degree of nonlinear compensation in the controller, a system property distinct from open-loop nonlinearity and determined by a performance objective and the region of operation as well as the nature of the open-loop system. This approach is extended to the analysis of multivariable systems with output feedback through the application of an extended Kalman filter. Coherence estimation is used as a practical method to measure continuous, open-loop multivariable system nonlinearity. The CSTR with van de Vusse kinetics, a system that features output feedback and a controllaw nonlinearity that changes with operating points, is analyzed. The optimal control structure approach with coherence estimation correctly indicates changes in the controllaw linearity between different operating points and changes as the regions of operation change around a particular operating point.
Nonparametric factorial analysis of daily weigh-in-motion traffic : implications for the ozone weekend effect in Southern California

Abstract The Ozone Weekend Effect (OWE) has become increasingly more frequent and widespread in southern California since the mid-1970s. Although a number of hypotheses have been suggested to explain the effect, there remains uncertainty associated with the root factors contributing to elevated weekend ozone concentrations. Targeting the time window of the 1997 Southern California Ozone Study (SCOS97), this paper examines traffic activity data for 14 vehicle classes at 27 weigh-in-motion (WIM) stations in southern California. Nonparametric factorial analyses of light-duty vehicle (LDV) and heavy-duty truck (HDT) traffic volumes indicate significant differences in daily volumes by day of week and between the weekly patterns of daily LDV and HDT volumes. Across WIM stations, the daily LDV volume was highest on Friday and decreased by 10% on weekends compared to that on midweek days. In contrast, daily HDT volumes showed dramatic weekend drops of 53% on Saturday and 64% on Sunday. As a result, LDV to HDT ratios increased by 145% on weekends. Nonparametric tests also suggest that weekly traffic patterns varied significantly between WIM stations located close to (central) and far from (peripheral) the Los Angeles Metro area. Weekend increases in LDV/HDT ratios were more pronounced at central WIM sites due to greater weekend declines of HDT relative to LDV traffic. The implications of these weekly traffic patterns for the OWE in southern California were investigated by estimating daily WIM traffic on-road running exhaust emissions of total organic gas (TOG) and oxides of nitrogen (NOx) using EMFAC2002 emission factors. The results support the California Air Resource Board's (CARB's) NOx reduction hypothesis that greater weekend NOx reductions relative to volatile organic compound (VOC) emissions, in combinations with the VOC-limited ozone system, contribute to the OWE observed in the region. The results from this study can be used to develop weekend on-road mobile emission inventories for the purpose of air quality modeling.
Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycle.

We have previously found that the ovarian steroid background determines the efficiency of the endothelin-mediated autocrine feedback regulation of prolactin (PRL) secretion. In this study, we investigated the role of endogenous endothelins in regulating PRL secretion during the estrous cycle. Adult female rats representing different stages of the 4-d cycle were sacrificed by decapitation, and the anterior pituitary cells were enzymatically dispersed using collagenase and hyaluronidase. PRL secretion of individual lactotrophs was measured in a PRL-specific reverse hemolytic plaque assay, and the influence of endogenous endothelins on PRL secretion was assessed by applying the selective ETA receptor antagonist peptide, BQ123. Blocking the endothelin-mediated autocrine feedback resulted in an increase in PRL secretion when cells were obtained at proestrus, estrus, and diestrus-1, whereas PRL secretion was decreased at diestrus-2 by ETA receptor blockade. These observations suggest that endogenous endothelins are predominantly inhibitory during proestrus, estrus, and diestrus-1, whereas at diestrus-2 their influence on PRL secretion in stimulatory. Whereas the bell-shaped concentration-response curves with BQ123 at proestrus and diestrus-1 may indicate a transition state in which endogenous endothelins can be both stimulatory and inhibitory, at estrus the influence of endogenous endothelins is unequivocally inhibitory in nature. We propose that intensification of the endogenous endothelin-mediated negative feedback at estrus may play a role in restraining PRL secretion following the estradiol-induced proestrous PRL surge.
Novel form of photonic crystals for bioimaging contrast enhancement

We report here a diatom frustule-based photonic structure acting as an efficient near infrared contrast agent. The frustule of diatom Pinnularia sp. consists of two valves with same exquisite fine 2D periodicity at the submicron scale, similar to a 2D photonic crystal. Decoration of diatom frustules with higher refractive index materials leads to a refractive indices contrast increase between the array of pores and the frame. Our calculation and measurements show that magnetite nanoparticle-decorated diatom frustules have a wide pseudo photonic band gap in near infrared range, resulting in a strong near infrared reflection. It allows the magnetite nanoparticle-decorated diatom frustules to be imaged with a high optical coherence tomography contrast.
Selective Neovascularization of the Retinal Pigment Epithelium in Rat Photoreceptor Degeneration in vivo

Photoreceptor cell degeneration in rodents from a variety of causes results in neovascularization of the retinal pigment epithelium as a late stage phenomenon. Even though the vessels within the pigment epithelium arise from the retinal circulation, they can manifest the choroidal endothelial cell phenotype of fenestrated endothelial cells. In order to study the detailed cellular events which result in incorporation of retinal vessels within the retinal pigment epithelium, a morphological and morphometric analysis of the RPE and vasculature was performed in rats. Urethane, given subcutaneously to newborn rats, results in a photoreceptor degeneration but does not affect the RPE, choroid or inner retinal layers. Retinas were studied from rats of 8 to 24 weeks of age, the time period when vascularization of the RPE occurs. Loss of retinal vessels is first seen at 12 weeks, primarily in substantial dropout of vessel profiles in the outer plexiform layer (OPL) vessel bed. There is a gradient of loss from the OPL bed to the nerve fiber layer (NFL) bed and from the central to peripheral region. Total vessel density of the experimental retinas is greater than controls at 8 and 12 weeks. This occurs because there is marked loss of retinal thickness, due to photoreceptor degeneration, without a comparable loss of vessel profiles. The total retinal vessel density decreases from 8 to 20 weeks, and appears to stabilize at 20 and 24 weeks. Analysis of the separate vessel beds shows that this apparent stabilization is due to continued loss of vessels within the sensory retina, and increased presence of vascular profiles within the RPE. Total absence of the photoreceptor cell is necessary for incorporation of vessels within the RPE. Since new vessel profiles develop in the RPE but not the adjacent sensory retina, we speculate that the RPE may stimulate neovascularization of the RPE. A model of the cellular events leading to RPE neovascularization is proposed.
In VitroReconstitution and Analysis of Mononucleosomes Containing Defined DNAs and Proteins

Abstract Increasingly, biochemical analyses of processes that occur within eukaryotic nuclei such as transcription and replication require the construction of specific chromatin substrates. Nucleosome complexes reconstituted in vitro have been key elements in a variety of recent studies of polymerase progression and trans -acting factor binding activities. Reconstituted complexes can be easily constructed from purified components in quantities suitable for biochemical and biophysical studies. In addition, reconstituted mononucleosome complexes exhibit native biochemical and biophysical properties but necessarily contain much less heterogeneity with regard to both protein and DNA components than bulk complexes isolated from natural sources. This review details the protocols for reconstitution of model mononucleosome complexes that contain unique DNA sequences and specifically tailored core histone proteins and describes common pitfalls associated with these procedures.
α-Defensins in Enteric Innate Immunity: FUNCTIONAL PANETH CELL α-DEFENSINS IN MOUSE COLONIC LUMEN*

Paneth cells are a secretory epithelial lineage that release dense core granules rich in host defense peptides and proteins from the base of small intestinal crypts. Enteric α-defensins, termed cryptdins (Crps) in mice, are highly abundant in Paneth cell secretions and inherently resistant to proteolysis. Accordingly, we tested the hypothesis that enteric α-defensins of Paneth cell origin persist in a functional state in the mouse large bowel lumen. To test this idea, putative Crps purified from mouse distal colonic lumen were characterized biochemically and assayed in vitro for bactericidal peptide activities. The peptides comigrated with cryptdin control peptides in acid-urea-PAGE and SDS-PAGE, providing identification as putative Crps. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry experiments showed that the molecular masses of the putative α-defensins matched those of the six most abundant known Crps, as well as N-terminally truncated forms of each, and that the peptides contain six Cys residues, consistent with identities as α-defensins. N-terminal sequencing definitively revealed peptides with N termini corresponding to full-length, (des-Leu)-truncated, and (des-Leu-Arg)-truncated N termini of Crps 1–4 and 6. Crps from mouse large bowel lumen were bactericidal in the low micromolar range. Thus, Paneth cell α-defensins secreted into the small intestinal lumen persist as intact and functional forms throughout the intestinal tract, suggesting that the peptides may mediate enteric innate immunity in the colonic lumen, far from their upstream point of secretion in small intestinal crypts.
Homogeneous Riccati equations versus quadratic inequalities

It is proved that, under certain hypotheses, the existence of hermitian solutions of a homogenized algebraic Riccati equation of continuous type is guaranteed if the corresponding quadratic inequality admits a hermitian solution. Both finite-dimensional (matrices) and infinite-dimensional (Hilbert space operators) Riccati equations are considered.
AFTEREFFECTS OF DELAYED AUDITORY FEEDBACK.

This experiment was designed to test whether there are aftereffects on speech to delayed auditory feedback and whether the aftereffects, if any, are a function of the severity of disruption of speech under the feedback condition. Fifty-seven Ss, divided into three equal groups, were exposed to various combinations of delay time and intensity of feedback. Comparisons of pre- and post-sidetone responses revealed no evidence of aftereffects on speech. No relationship to induced severity of speech disruption was found.
Quantitative aspects of the eccentric cell dendrite of the lateral eye of Limulus.

Eccentric cell dendrites (ECD) from ommatidia of lateral eyes ofLimulus polyphemus were examined. The number of mitochondrial profiles per transverse section (N), the ‘level’ of the section as measured from the distal tip of the dendrite, and the cross-sectional area of the dendrite (A) were measured and it was found thatN=kA1.5. Microvilli of the ECD were traced by means of serial sections; also microvilli attributable to the ECD were counted and their lengths measured. It was concluded that the dendritic surface area is between 10 and 50 times greater than that of a smooth dendrite.
One role or two?: The function of psychological separation in role conflict.

Student athletes vary in how much they view their academic and athletic role identities as separate from and interfering with each other. The authors investigated the relation of these perceptions to psychological well-being in 200 intercollegiate athletes. Measures included role separation, interference, identity, and well-being. Correlations indicated that interference related negatively to well-being, whereas viewing the roles as distinct related positively to well-being. Regression analyses of demographic and role identity variables also showed a positive association between role separation and well-being, and a significant Separation x Interference interaction. Specifically, role interference was negatively related to well-being for those who viewed the two roles as distinct but unrelated for those who did not. The buffering effects of role separation are discussed.
A cross-seasonal comparison of active and total bacterial community composition in Arctic tundra soil using bromodeoxyuridine labeling

Arctic soil microorganisms remain active at ecologically relevant rates in frozen soils. We used bromodeoxyuridine (BrdU) labeling and terminal restriction fragment length polymorphism (T-RFLP) analysis of 16S rRNA gene amplicons to examine active bacterial communities in two Alaskan tundra soils collected in summer and winter of 2005. Active community T-RFLP profiles were compared to total community profiles to determine if active bacteria were a subset of the total community. In shrub soils, active bacteria communities differed in composition between summer and winter, and winter-active bacterial taxa were not detected in the total community, suggesting that they are likely rare within the overall community. In contrast, tussock tundra soil contained more bacterial taxa that were active in both summer and winter and also represented a large portion of the total community. Using in silico digest of a sequence library from this site, we attempted to identify the dominant organisms in our samples. Our previous research suggested that the total microbial community was stable throughout the year, but this new study suggests that the active community is more dynamic seasonally. In general, only a subset of the total community was growing at a given time. This temporal niche partitioning may contribute to the high diversity of microbial communities in soils. Understanding which taxa contribute to microbial function under different conditions is the next frontier in microbial ecology and linking composition to biogeochemical cycling.