cssi/SciSciGPT-SciSciNet huggingface dataset:
Global Mental Health Needs, Services, Barriers, and Challenges

Mental health problems represent 5 of the 10 leading causes of disability in the world and affect as many as 500 million people. The direct and indirect burden of mental health problems is great. Limited resources are devoted to mental health care, and there are many barriers to receiving it. Stigma, human rights violations, war, and migration contribute to the problem. We need to do much more to address this critical issue.
Dynamic classifier combination using neural network

There is an increasing trend in recent OCR research to improve recognition performance by combining several complementary algorithms. Numerous successful applications of classifier combination have been described in the literature. However, most of the combination algorithms neglect the fact that classifier performances are dependent on various pattern and image characteristics. More effective combination can be achieved if that dependency information is used to dynamically combine classifiers. Two types of dynamic selections are distinguished. The postconditioned selection seeks better approximation to unconditioned classifier output distribution. The preconditioned selection captures the variations in the density function of classifier outputs conditioned on the inputs. Although both types of selections have the potential to improve combination performance, we argue that preconditioned selections have lower error bounds than postconditioned selections. The difficulties of applying preconditioned selections are identifying characteristic variables and estimating their effects on classifier outputs. A solution using neural network to achieve preconditioned selection is suggested. Two examples on handprinted digit recognition are used to illustrate the potential gain.© (1995) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Testicular Cancer and Genetics Knowledge Among Familial Testicular Cancer Family Members

Purpose It was our aim to determine baseline levels of testicular cancer and genetics knowledge among members of families with Familial Testicular Cancer (FTC).
Trophic Control of Production in a Rocky Intertidal Community

In the low intertidal zone at Tatoosh Island, Washington, United States, minimal estimates of primary production can vary from 0 to an average of 86 kilograms of wet mass per square meter per year when the grazing assemblage is manipulated. Highly productive annual kelps (Laminariales) replace less productive perennial species when macroscopic grazers are reduced or absent, resulting in monodominant assemblages of Alaria marginata. Experiments were repeated in seven consecutive years. Increased species richness makes no significant additional contribution to annual production. Rather, a competitively superior species is favored when its enemies are reduced, suggesting that terrestrial perspectives on the role of biodiversity that are developed without considering consumers may not be general.
Effect of total body x-irradiation on some enzymes of rat tissues.

Abstract Rats were subjected to 600 roentgens of total body x-irradiation, and changes in enzyme activities and oxygen uptake were studied for a 12-day period. Changes were observed in liver catalase, xanthine oxidase, ribonuclease, and serum lipase. No significant alterations were observed in oxygen uptake of liver and kidney, or in choline oxidase, lipase, and cathepsin activity of liver.
Using Social Psychology to Motivate Contributions to Online Communities

Under-contribution is a problem for many online communities. Social psychology theories of social loafing and goal-setting can lead to mid-level design goals to address this problem. We tested design principles derived from these theories in four field experiments involving members of an online movie recommender community. In each of the experiments participated were given different explanations for the value of their contributions. As predicted by theory, individuals contributed when they were reminded of their uniqueness and when they were given specific and challenging goals. However, other predictions were disconfirmed. For example, in one experiment, participants given group goals contributed more than those given individual goals. The article ends with suggestions and challenges for mining design implications from social science theories.
Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

How insulin binds to and activates the insulin receptor has long been the subject of speculation. Of particular interest are invariant phenylalanine residues at consecutive positions in the B chain (residues B24 and B25). Sites of mutation causing diabetes mellitus, these residues occupy opposite structural environments: PheB25 projects from the surface of insulin, whereas PheB24 packs against the core. Despite these differences, site-specific cross-linking suggests that each contacts the insulin receptor. Photoactivatable derivatives of insulin containing respective p-azidophenylalanine substitutions at positions B24 and B25 were synthesized in an engineered monomer (DKP-insulin). On ultraviolet irradiation each derivative cross-links efficiently to the receptor. Packing of PheB24 at the receptor interface (rather than against the core of the hormone) may require a conformational change in the B chain. Sites of cross-linking in the receptor were mapped to domains by Western blot. Remarkably, whereas B25...
A Follower of Jean Pucelle in England

The name of Jean Pucelle has come to symbolize the introduction of the arte nuovo of Giotto and Duccio into northern European painting. In the words of Erwin Panofsky, “if any major event in the history of art can be credited to one individual, the initiation of this process must be ascribed to an artist to whom I shall continue to refer by the traditional appellation of Jean Pucelle, active at Paris from ca. 1320.”1 Whether “Jean Pucelle” in fact identifies a single or a composite artistic personality remains uncertain. Nevertheless, a general conception of the Pucelle style has been developed on the basis of the three manuscripts of the 1320's that are connected with this name: the Belleville Breviary, the Hours of Jeanne d'Evreux and the Billyng Bible.2 Whatever part Jean Pucelle himself had in these three works, as a group they present a number of features that may be called proto-Renaissance: sculpturally modeled figures; three-dimensional treatment of space; and a new form of psychological expression.3
PHOTOCHEMICAL REACTIONS OF THYMINE, URACIL, URIDINE, CYTOSINE AND BROMOURACIL IN FROZEN SOLUTION AND IN DRIED FILMS*

(Received 24 May, 1963) Abstract-The photochemistry of uracil, uridine, cytosine, thymine and broinouracil has been investigated in frozen aqueous solution and in dried films. Essentially the same photo- products were obtained in the two conditions; however, the yield of photoproducts was considerably greater in frozen solution. Uracil forms a dimer which can exist in two forms. Some kinetic data are presented for the interconversion of these two forms, The mixed diiiier of thymine and uracil can also exist in two forms. Uridine forms only one acid stable photo- product and does not appear to form mixed photoproducts under the conditions used. Two new photoproducts of thymine other than the dimer are described. Cytosine was at first considered to be completely inert hut using more sensitive detecting equipment it has recently been found to form uracil dinier as a result of dinierization and deamination. The most remarkable response was shown by bromouracil. When irradiated by itself it formed no photoproducts but when irradiated in the presence of uracil, uridine, cytosine or NaOH it formed many photoproducts. Most of these products were devoid of bromide, but two still contained bromine. One of these has been identified as the mixed dimer of uracil and bromouracil while the other has been tentatively identified as the dimer of bromouracil. Dimers of thymine or bromouracil were not formed by X-rays. IN 1928 GATES(~O) pointed out the probable relation between the bactericidal effectiveness of the various wave lengths of ultraviolet light (u.v.) and the absorption of U.V. by deoxy- ribonucleic acid (DNA), but it was not until some twenty-one years later that a photo- chemical reaction of the pyrimidines was described that appeared to be of biological importance. In 1949 Sinsheimer and Hastings(20) reported the reversible photochemical alteration of uracil and cytidylic acid. It was ultimately shown by Moore(16) that this reaction, which involves the reversible hydration of the 5-6 double bond of uracil, yields (j-hydroxy, 5-hydro uracil. In 1960, Beukers and Berendd2) reported that the irradiation of thymine in frozen solution resulted in the formation of a thymine dimer. This dinier was also found in DNA when irradiated in vitrd6) and in the DNA of bacteria when irradiated i?r V~VO(~~). We had been studying the radiation sensitizing effect of the in- corporation of base analogs, such as 5-bromo~racil('~* 14), into DNA. It seemed of interest
Species-specificity of temporal processing in the auditory midbrain of gray treefrogs: interval-counting neurons

Interval-counting neurons (ICNs) respond after a threshold number of sound pulses have occurred with specific intervals; a single aberrant interval can reset the counting process. Female gray treefrogs, Hyla chrysoscelis and H. versicolor, discriminate against synthetic ‘calls’ possessing a single interpulse interval 2–3 three times the optimal value, suggesting that ICNs are important for call recognition. The calls of H. versicolor consist of pulses that are longer in duration, rise more slowly in amplitude and are repeated at a slower rate than those of H. chrysoscelis. Results of recordings from midbrain auditory neurons in these species include: (1) ICNs were found in both species and their temporal selectivity appeared to result from interplay between excitation and inhibition; (2) band-pass cells in H. versicolor were tuned to slower pulse rates than those in H. chrysoscelis; (3) ICNs that were selective for slow-rise pulse shape were found almost exclusively in H. versicolor, but fast-rise-selective neurons were found in both species, and (4) band-suppression ICNs in H. versicolor showed response minima at higher pulse rates than those in H. chrysoscelis. Selectivity of midbrain ICNs for pulse rise time and repetition rate thus correlate well with discriminatory abilities of these species that promote reproductive isolation.
Synthesis and linear and nonlinear absorption properties of dendronised ruthenium(II) phthalocyanine and naphthalocyanine

Ruthenium phthalocyanines and naphthalocyanines with axial dendronised pyridine ligands show high solubility in a variety of solvents, and exhibit solid-state absorption spectra that are comparable to those obtained in dilute solution, making them interesting candidates for optical limiting in the visible.
Synthesis of ABA Triblock Copolymers via Acyclic Diene Metathesis Polymerization and Living Polymerization of α-Amino Acid-N-Carboxyanhydrides

The synthesis of poly(γ-benzyl-l-glutamate)-b-polyoctenamer-b-poly(γ-benzyl-l-glutamate) (13) and poly(γ-benzyl-l-glutamate)-b-polyethylene-b-poly(γ-benzyl-l-glutamate) (14) triblock copolymers is described. α,ω-Bisamino-terminated polyoctenamer (5) was used to prepare a difunctional macroinitiator (12) used for the living polymerization of γ-benzyl-l-glutamic acid−N-carboxyanhydride (Glu−NCA) to form the triblock copolymers. 5 was synthesized by acyclic diene metathesis polymerization of 1,9-decadiene (1) in the presence of 11-phthalimido-1-undecene (2) and Grubbs' metathesis catalyst, RuCl2(CHPh)(PCy3)2 (3). Deprotection of the resulting phthalimide end-functionalized polymers (4) was performed, leading to difunctional 5 with number-average functionalities close to two. These methods allow the controlled preparation of polypeptide/(hydrocarbon polymer) block architectures with good control over the chain lengths of both domains and without formation of homopolypeptide contaminants.
Higher order approximations to the natural convection flow over a uniform flux vertical surface

Abstract Perturbation analysis of higher order boundary-layer effects for convection flow over a semi-infinite vertical uniform flux surface is presented. Using asymptotic matching technique, three term inner and outer expansions have been obtained. Eigenvalues and their eigenfunctions associated with the inner expansions have also been investigated and it has been shown that their contribution to these three term expansions is identically zero. The numerical results for Pr = 0.733 and 6.7 show that the higher order corrections to the local temperature difference and the local skin friction are negative but are positive to the local Nusselt number. Considerations of global momentum and buoyancy indicate an indeterminacy of O(1) in the expression for total drag.
Image processing in a general purpose microcomputer

SUMMARY Video images from light and electron microscopes can be acquired in ‘digital’ form within a personal computer, using standard peripherals and interfaces. In addition to providing for measurement of such images (counting of features by size class, integration of density, etc.) the stored image can be processed in a variety of ways. Using techniques known in the image processing field but only recently practical in such small computers, smoothing of the grey-scale information, sharpening of edges, extraction of texture information, directional derivatives, and shifts of grey scale can be applied. Combination of images with previous ones stored on disk is especially useful for electron and X-ray images from SEM. The system described carried out all operations in software, typically requiring times of 1–20 s per image which should be practical in many microscopy laboratories.
Identification of the chemical difference between chromatographic components of ribonuclease

Abstract Differences in the isoionic points and titration curves of two chromatographic components of crystalline ribonuclease can be ascribed quantitatively to a difference of one in the number of free carboxyl groups. Other quantitative properties of the components agree so closely that it is probable that no other difference between the components exists.
NORMAL VALUES FOR VENTILATORY FUNCTION IN RHODESIAN AFRICANS

Abstract Forced vital capacity, forced expiratory volume in 1 sec and peak expiratory flow were measured in 141 African men and 102 African women aged 20 and above. Prediction formulae relating each measurement to height and age were drawn up and are presented. Rhodesian Africans have lower values for these measurements than subjects in some European and North American series, but broadly similar values to those of Africans elsewhere.
FUV and EUV spectrographs: Development in the 1980s for astronomy in the 1990s

This is a review of the rapid developments of the technology for spectrographs to support the unique and difficult requirements of FUV and EUV astronomy. During the 1980's a variety of novel techniques have been incorporated into instrument designs that will collect data in the 1990's. This review summarizes the progress these spectrographs will allow, highlights the challenges that FUV and EUV astronomy will present for the following generation of observatory design, and discusses some of the possible routes to overcoming those challenges.
Procedural Justice and Culture

Abstract The past fifteen years have seen the development of a considerable research literature on the social psychology of procedural justice (see Lind & Tyler, 1988, for a review). Procedural justice research reveals some serious shortcomings in the exchange theories that have traditionally dominated Western analyses of the social psychology of groups, and in so doing, the procedural justice literature has important ramifications for cross–cultural psychology. Results from a number of studies conducted in the United States and Western Europe show that individualistic, self–interest based models of human behaviour are insufficient to explain procedural justice phenomena. Instead, procedural justice effects frequently reveal strong group–oriented concerns and motivations even in cultural contexts generally thought to be characterized by individualistic orientations. The research literature also shows that if a group's procedures are judged to be fair, people are more likely to show group–oriented behaviou...
High-power single mode operation of hybrid ion-implanted/selectively-oxidized VCSELs

We first present numerical simulations that quantify this approach by predicting lateral mode discrimination for different sized gain apertures. These calculations are experimentally confirmed by the fabrication and testing of 850 nm VCSELs employing hybrid ion implantation/selective oxidation that produce a single-mode output of more than 5 mW. We performed VCSEL simulations using a 2D axisymmetric finite-difference code that solves for cavity eigenmodes including both mode shape and energy loss rate for a realistic VCSEL structure that includes gain and loss in the quantum well(s). We chose a VCSEL comprised of a 1-/spl Lambda/ cavity containing a single 100 A quantum well with 34 DBR pairs.
Inquiry-Based Environments for the Inclusion of Students With Exceptional Learning Needs

A qualitative study of children's museums' successful inquiry-based learning environments is described, focusing on four students with various exceptional learning needs. Benefits for the students in terms of scaffolded instruction, meaningful and contextualized activities, self-regulated learning, the establishment of learning communities, play, and parental involvement are noted. A discussion of the generalization of learning to the classroom and of positive attitudes and children's museums as inclusive, supplemental environments is included. Implications for future practice involve school—museum partnerships and individualized programming for all learners.
Ideologies of Attachment in the Story of Naboth's Vineyard

According to 1 Kings 21:1–16, Ahab sought to purchase the vineyard of Naboth, which adjoined the royal estate in Jezreel. Although Ahab offered a fair price or replacement land, Naboth declined: “Y...
Modeling the Dynamics of Transaction Prices on the NYSE in a Bayesian State-Space Filtering Framework

Traditional models for the dynamics of stock prices are discrete-time, univariate and cross-sectional time series based on monthly, weekly, and daily data with continuous-valued sample spaces. With intraday data at the transaction level, these models are inappropriate. We can no longer assume that prices change in a continuous fashion. Instead prices trade at discrete increments of monetary value, a tick, which is $0,125 for the New York Stock Exchange (NYSE). Also, stocks trade at unequally-spaced intervals of time which can vary considerably over the trading day.
Political Parties and the Recruitment of Women to State Legislatures

This article analyzes the role of political parties in shaping women's representation across the U.S. states. Using data from 1971 to 1999, I analyze several hypotheses about how party affects women's recruitment to the lower houses of state legislatures. I argue that the incentive structure facing potential women candidates is somewhat different for Democratic and Republican women. The social eligibility pool, legislative professionalism, and partisan composition of the legislature affect women's representation differently by party. Rather than assuming a single path for women to elective office, this research implies that it is necessary to disaggregate women by party in order to understand the pattern of where women run for and hold state legislative office.
Transaction based pre-to-post silicon validation

Intel's move towards the SoC paradigm comes with a compelling requirement for shorter time-to-market. To address that, we need to make both pre and post silicon validation more efficient. In this paper we focus on post-si functional validation, which consumes an increasing share of the overall product development timeline. We present a coherent Pre-to-Post workflow that aims to improve productivity of post-si validation and debug by proper investment in design for debug / validation (DFx) and in test development during pre-si stages. In this workflow, a central transactions and events definition repository serves as the backbone across pre-Si and post-Si activities. The transaction spec guides DFx work in pre-Si as well as test suite preparation in order to make the post-Si validation work productive. Usage of micro-architectural events and transactions raises the level of abstraction, and can help in getting better productivy, manageability, reusability, and less error prone Post-Si validation work.
Ventricular Arterial Stiffening: Integrating the Pathophysiology

Vascular stiffening of the large arteries is a common feature of aging and is exacerbated by many common disorders such as hypertension, diabetes, and renal disease. This change influences the phasic mechanical stresses imposed on the blood vessels that in turn is important to regulating smooth muscle tone, endothelial function, and vascular health. In addition, the heart typically adapts to confront higher and later systolic loads by both hypertrophy and ventricular systolic stiffening. This creates altered coupling between heart and vessel that importantly affects cardiovascular reserve function. In this overview, I discuss the notion of a coupling disease in which stiffness of both heart and arteries interact to limit performance and generate clinical symptoms. This involves changes in the mechanical interaction of both systems, changes in signaling within the arteries themselves, and alterations in coronary flow regulation. Lastly, I briefly review recent development in de-stiffening strategies that may pave the way to treat this syndrome and its clinical manifestations.
Maternal addiction, child maladjustment and socio-demographic risks: implications for parenting behaviors.

Aims. In this study we examined three parenting dimensions (involvement, autonomy, and limit-setting) and three potential determinants (maternal addiction, low SES and its correlates, and mothers' perceptions of their children's maladjustment) in order to disentangle features of parenting that are uniquely related to maternal addiction from those related to contextual determinants. We also examined conditional effects of low SES and its correlates on parenting. Design. Based on a literature review and predictions arising from an ecological model of parenting, we expected that maternal addiction would be related with problems in parental involvement, but that the other parenting dimensions would be related with mothers' perceptions of children's maladjustment and low SES. Accordingly, we examined variance in each parenting dimensions accounted for by each of the three determinants, respectively. Participants. Subjects included 120 (69 opiate-addicted and 51 SES-matched comparison) mothers with children under 16 years of age. Measurements. Children's maladaptive behavior was assessed with the Behavioral Assessment System for Children, and parental adjustment with the Parent Child Relationship Inventory. Findings. Direct effect predictions were confirmed and two conditional effects involving single status and family size were also found. Conclusions. Although many parenting problems have previously been attributed to maternal addiction, only parental involvement is directly related to being an addict; other parenting dimensions may be better explained by contextual factors.
Life-Closing Spirituality and the Philosophic Assumptions of the Roy Adaptation Model

Secondary analysis of data from a previous study that referenced spirituality was coded, categorized, and grouped into themes. Life-closing spirituality for 44 (45.4%) of 97 total participants was shaped by a core theme of believing that was central to dying persons. Believing was linked to six other themes: comforting, releasing, connecting, giving, reframing, and requesting. These themes supported the philosophic assumptions and principles of humanism and veritivity as defined in the Roy adaptation model.
Kentucky Wealth at the End of the Eighteenth Century

The Kentucky tax lists from 1800 to 1860 permit a study of both the trend in per capita wealth and the change in the relative distribution of wealth in this strategic state from the time of its inception to the Civil War. Real wealth per capita is judged to have increased 2.4 percent a year from 1800 to 1840, and 2.8 percent from 1840 to 1860. Relative inequality remained roughly constant, with the Gini coefficient .80 in both 1800 and 1860 for adult free males. The number of properties held by various individuals was surprisingly unequal in distribution in 1800 and 1820.
Ocular trauma resulting in enucleation: a 12-year experience from a large regional institution

PURPOSE: To review the frequency and cause of traumatic enucleation at the University of Wisconsin. METHODS: A 12-year retrospective chart review (2000-2012) from the University of Wisconsin Hospital and Clinics of patients who underwent enucleation following ocular trauma with specimens submitted to the University of Wisconsin Eye Pathology Laboratory. RESULTS: A total of 188 eyes enucleated following ocular trauma were identified between 2000 and 2012. One hundred eleven (59%) cases had an identifiable mechanism of injury recorded in the medical record and were included in the final analysis. The overall median patient age was 41 years with 83.8% male. Assault was the most common reason for enucleation (n=30, 27.0%) of which 15 (13.5%) cases were related to gunshot wounds. Other causes included outdoor or recreational activities (n = 20, 18.0%), fall (n = 14, 12.6%), non-motor vehicle accidents (n = 6, 5.5%), motor vehicle accidents (n = 15, 13.5%), work-related injury (n = 15, 13.5%), and sports-related injury (n = 11, 10%). CONCLUSION: Assault is the most common cause of traumatic ocular injury leading to enucleation. Gunshot and stab wounds were responsible for the majority of these cases. Men were much more likely to undergo enucleation due to ocular trauma with the exception being that caused by falls, where the rate was nearly equal between men and women. Language: en
Technology development for natural product biosynthesis in Saccharomyces cerevisiae

The explosion of genomic sequence data and the significant advancements in synthetic biology have led to the development of new technologies for natural products discovery and production. Using powerful genetic tools, the yeast Saccharomyces cerevisiae has been engineered as a production host for natural product pathways from bacterial, fungal, and plant species. With an expanding library of characterized genetic parts, biosynthetic pathways can be refactored for optimized expression in yeast. New engineering strategies have enabled the increased production of valuable secondary metabolites by tuning metabolic pathways. Improvements in high-throughput screening methods have facilitated the rapid identification of variants with improved biosynthetic capabilities. In this review, we focus on the molecular tools and engineering strategies that have recently empowered heterologous natural product biosynthesis.
Tunable 44 mJ, 290 nm UV source based on solid state dye laser technology and CLBO harmonic generation

Tunable UV in the range 284-294 nm was obtained with up to 15% absolute conversion efficiency from a 532 nm Nd:YAG pumped high-brightness solid state dye laser, frequency doubled in CLBO.
Modeling and analysis of propulsion in the multiflagellated micoorganism Giardia lamblia

The goal of this work was to analyze the propulsion of multiflagellated microorganisms, and to draw insight to the underlying physics and biology of the movement. Giardia lamblia was chosen as the model organism due to its unique ability to mechanically attach to various surfaces, its rapid movement, and its fine control over steering and navigation. In this work, a mechanics model was utilized to study the mechanics and propulsive contribution of the ventral and anterior flagella in Giardia. It was discovered that energy is supplied mainly at the proximal portion of these flagella, supporting the hypothesis that a decreasing adenosine triphosphate (ATP) gradient along the length of the flagella would not affect the motion observed. Similarly, the elasticity of the flagella allows the energy input at the proximal portion to be transferred to the distal portion, where the majority of thrust is generated. Specifically, we found that the ventral flagella are the driving force for planar propulsion and turning, while the anterior flagella are used for steering and control.
Laser surgery for benign laryngeal disease. Conservation and ergonomics.

In surgery, the era of tissue conservation and advanced engineering ergonomics has arrived. As a surgical tool, lasers will undergo extensive development. The most precise of surgical tools, its ability to focus to spots equal to its wavelength will permit intracellular surgery. A new technology must be mastered by the operator, who must have a solid foundation in laser physics. The small spot size possible with the new laser laryngoscopy coupler introduces one more refinement in the growing trend toward “conservational” surgery of the larynx for both benign and malignant laryngeal disease.
Studies of amyloid beta-protein precursor expression in Alzheimer's disease.

The generation of the beta/A4 peptide and its accumulation into insoluble amyloid deposits represent key events in the neuropathologic process of Alzheimer's disease (AD). This posit has gained further support from recent reports that beta/A4 is directly responsible for the death of neurons. Potential therapies for AD aimed at abating the production of beta/A4 will require the basic knowledge of where it comes from. The 4.2-kD peptide is derived from a much larger amyloid precursor protein (APP) encoded by a gene that produces multiple transcripts. Employing in situ hybridization with biotinylated oligonucleotide probes, we set out to define which forms of the precursor are synthesized in affected regions of AD brain (e.g., hippocampal formation) and to determine the cell populations responsible for their manufacture.
On evaluating the use of Zachman framework in computer science and information systems classes

Enterprise Architecture (EA) is concerned with how an organization's assets are to be utilized to obtain a set of desired information technology outcomes. The Zachman Framework (ZF) has started the studies in EA. ZF provides an effective meta-model for large scale information systems by means of a set of architectures. ZF has essentially become an indispensable component of any Information Systems (IS) related field. While ZF has been pervasively used in the private and public sectors, to the best of our knowledge, it has found almost no place, other than only one limited application, in computing classrooms, as reported in the literature. In this paper, we report the first proposal to make use of the ZF in many Computer Science (CS) and IS courses. We describe how we have incorporated it in a database class at a 4-year institution and forensics and network intrusion classes at a community college. We present assessment results showing promising results for improved student learning based student self-reported responses. Pedagogically, our application is grounded in the Gagnes Conditions of Learning, the Instructional Design Theory, and a goal-oriented methodology.
Insurance Type and Solid Organ Transplantation Outcomes: A Historical Perspective on How Medicaid Expansion Might Impact Transplantation Outcomes

Background The number of Medicaid beneficiaries has increased under the Affordable Care Act, improving access to solid organ transplantation in this disadvantaged patient cohort. It is unclear what impact Medicaid expansion will have on transplantation outcomes. We performed a retrospective cohort analysis to measure the frequency and variation in Medicaid transplantation and post-transplantation survival in Medicaid patients. Study Design Adult heart, lung, liver, and renal transplant recipients between 2002 and 2011 (n = 169,194) reported to the Scientific Registry of Transplant Recipients were identified. Transplant recipients were classified based on insurance status (private, Medicare or Medicaid). Outcomes measures included 5-year post-transplantation survival, summarized using Kaplan-Meier curves and compared with log-rank tests. Organ-specific Cox proportional hazards models were used to adjust for donor and recipient factors. Results Medicaid patients comprised 8.6% of all organ transplant recipients. Fewer transplantations were performed than expected among Medicaid beneficiaries for all organs except liver (liver: observed to expected ratio = 1.21; 95% CI, 0.68–1.90; heart: observed to expected ratio = 0.89; 95% CI, 0.44–1.49; lung: observed to expected ratio = 0.57; 95% CI, 0.22–1.06; renal: observed to expected ratio = 0.32; 95% CI, 0.08–0.72). Medicaid transplant recipients were listed with more severe organ failure and experienced shorter transplant wait times. Post-transplantation survival was lower in Medicaid patients compared with private insurance for all organs. Post-transplantation survival in Medicaid patients was similar to Medicare patients for heart, liver, and renal but lower in lung. Conclusions Medicaid organ transplant beneficiaries had significantly lower survival compared with privately insured beneficiaries. The more severe organ failure among Medicaid beneficiaries at the time of listing, suggested a pattern of late referral, which might account for worse outcomes. Implementation of the Affordable Care Act gives the opportunity to develop the necessary infrastructure to ensure timely transplantation referrals and improve long-term outcomes in this vulnerable population.
A Comparison of the Academic Grades and Intelligence Scores of Participants and Nonparticipants in Intramural Athletics at the University of Kentucky

(1938). A Comparison of the Academic Grades and Intelligence Scores of Participants and Nonparticipants in Intramural Athletics at the University of Kentucky. Research Quarterly. American Association for Health and Physical Education: Vol. 9, No. 1, pp. 94-99.
Computational Prediction of c-MYC Binding and Action by Integration of Multiple Data Sources.

Abstract c-MYC is an important proto-oncogene. Its actions are mediated by sequence specific binding of the c-MYC protein to genomic DNA. While many c-MYC recognition sites can be identified in c-MYC responsive genes, many others are associated with genes showing no c-MYC response. It is not yet known how the cell determines which of the many c-MYC recognition sites are biologically active and directly bind c-MYC protein to regulate gene expression. We have developed a computational model that predict c-MYC binding and functional activation as distinct processes. Our model integrates four types of evidence to predict functional c-MYC targets: genomic sequence, MYC binding, gene expression and gene function annotations. First, a Bayesian network classifier is used to predict c-MYC recognition sites likely to exhibit high occupancy binding in chromatin immunoprecipitation studies using several types of sequence information, including predicted DNA methylation using a computational model to estimate the likelihood of genomic DNA methylation. In the second step, the DNA binding probability of MYC is combined with the gene expression information from 9 independent microarray datasets in multiple tissues and the gene function annotations in Gene Ontology to predict the c-MYC targets. The prediction results were compared with the c-MYC targets in public MYC target database [ www.myccancergene.org ], which collected the c-MYC targets identified in biomedical literatures. In total, we predicted 599 likely c-MYC genes on human genome, of which 73 have been reported to be both bound and regulated by MYC, 83 are bound by MYC in vivo and another 93 are MYC regulated. The approach thus successfully identified many known c-MYC targets as well as suggesting many novel sites including many sites that are remote from the transcription start site. Our findings suggest that to identify c-MYC genomic targets, any study based on single high throughput dataset is likely to be insufficient. Using multiple gene expression datasets helps to improve the sensitivity and integration of different data sources helps to improve the specificity. Summary of c-MYC Targets Prediction Microarray Dataset Data Source (Citation) Tissue Predicted Targets Binding&Regulation Reported Only Binding Reported Only Regulation Reported 1 PMID: 15778709 B Cell 421 61 60 56 2 PMID: 12086878 Prostate Cancer 428 56 65 76 3 PMID: 14722351 Prostate Cancer 50 4 7 13 4 PMID: 15254046 Prostate Cancer 66 19 8 14 5 PMID: 12747878 Breast Cancer 17 1 3 5 6 PMID: 11707567 Lung Cancer 295 51 42 59 7 PMID: 15820940 CML 8 1 1 2 8 PMID: 12704389 ALL 222 45 32 46 9 PMID: 11731795 ALL / MLL / AML 22 6 1 6 Total 599 73 83 93
Influence of team identification, game outcome, and game process on sport consumers’ happiness

Abstract The purpose of the study is to examine the relative effects of game process (i.e., boring versus exciting) and outcome (i.e., losing versus winning) on sport consumers’ happiness depending on their level of team identification. The authors investigated how sport consumers’ levels of happiness are different after recalling (Study 1) and imagining (Study 2) a game when the positivity of the game process and the outcome contradict each other. Results indicate that sport consumers with high team identification exhibited greater degrees of happiness after recalling and imagining a boring win game compared to an exciting loss game. Meanwhile, sport consumers with low team identification exhibited similar degrees of happiness between a boring win game and an exciting loss game.
A review of localized juvenile periodontitis (LJP): Part I. Clinical features, epidemiology, etiology, and pathogenesis.

Abstract Localized juvenile periodontitis (LJP) is not commonly encountered in dental practice. Yet, when it is encountered, prompt and effective therapy is required to combat the severity of disease and its rapid progression. Failure to understand its diagnosis and etiology leads to failures in management of LJP. The clinical features, etiology, and pathogenesis of LJP are reviewed to provide the clinician with a sufficient understanding to appropriately manage or refer LJP patients.
A new method to identify threshold logic functions

An Integer Linear Programming based method to identify current mode threshold logic functions is presented. The approach minimizes the transistor count and benefits from a generalized definition of threshold logic functions. Process variations are taken into consideration. Experimental results show that many more functions can be implemented with predetermined hardware overhead, and the hardware requirement of a large percentage of existing threshold functions is reduced.
Coronary Artery Disease in Patients With Out-of-Hospital Refractory Ventricular Fibrillation Cardiac Arrest

Abstract Background The prevalence of coronary artery disease (CAD) among patients with refractory out-of-hospital (OH) ventricular fibrillation (VF)/ventricular tachycardia (VT) cardiac arrest is unknown. Objectives The goal of this study was to describe the prevalence and complexity of CAD and report survival to hospital discharge in patients experiencing refractory VF/VT cardiac arrest treated with a novel protocol of early transport to a cardiac catheterization laboratory (CCL) for extracorporeal life support (ECLS) and revascularization. Methods Between December 1, 2015, and December 1, 2016, consecutive adult patients with refractory OH VF/VT cardiac arrest requiring ongoing cardiopulmonary resuscitation were transported by emergency medical services to the CCL. ECLS, coronary angiography, and percutaneous coronary intervention were performed, as appropriate. Functionally favorable survival to hospital discharge (Cerebral Performance Category 1 or 2) was determined. Outcomes in a historical comparison group were also evaluated. Results Sixty-two (86%) of 72 transported patients met emergency medical services transport criteria. Fifty-five (89%) of the 62 patients met criteria for continuing resuscitation on CCL arrival; 5 had return of spontaneous circulation, 50 received ECLS, and all 55 received coronary angiography. Forty-six (84%) of 55 patients had significant CAD, 35 (64%) of 55 had acute thrombotic lesions, and 46 (84%) of 55 had percutaneous coronary intervention with 2.7 ± 2.0 stents deployed per patient. The mean SYNTAX score was 29.4 ± 13.9. Twenty-six (42%) of 62 patients were discharged alive with Cerebral Performance Category 1 or 2 versus 26 (15.3%) of 170 in the historical comparison group (odds ratio: 4.0; 95% confidence interval: 2.08 to 7.7; p Conclusions Complex but treatable CAD was prevalent in patients with refractory OH VF/VT cardiac arrest who also met criteria for continuing resuscitation in the CCL. A systems approach using ECLS and reperfusion seemed to improve functionally favorable survival.
The U.S. Department of State’s Mental Health Services: A Model for Integrated Care

Since it was established in 1979, the U.S. Department of State’s mental health service has functioned as a unique program of care for U.S. diplomats and their family members, currently encompassing more than 250 U.S. embassies and consulates worldwide. Such an approach has allowed for rapid delivery of high-quality care in collaboration with regional medical officers, nurse practitioners, physician assistants, nurses, and local assets. Data from the past three decades indicate that the program has had low rates of medical evacuation and repatriation and low rates of mortality. Building from its roots in disaster and crisis response, the program now offers integrated mental health care in a geographically distributed, worldwide program to address the general medical and behavioral health needs of an expanding U.S. diplomatic presence in increasingly remote, challenging, and dangerous environments.
Predators of the tarnished plant bug, Lygus lineolaris (Heteroptera: Miridae): laboratory evaluations.

Twenty-five arthropod species, field-collected from habitats adjacent to cotton in Mississippi, were evaluated in laboratory arenas for their potential as late-season predators of the tarnished pla...
What to do About Unilateral Refusals to License

There are well-known circumstances under which unilateral refusals to license will cause harm to competition, that is, will lower consumer welfare. However, when the strategy is profitable, refusals to license also increase the returns to intellectual property, and thus limitations on them will reduce the incentives for firms to invest in innovation. The optimal balance between innovation incentives and protection against static monopoly harm is not knowable to any reasonable degree of precision. Economists may be able to identify some special cases in which the desired rule is unambiguously knowable, but these cases will be few. Given a policy or legal rule, economists can help interpret and apply the rule. Analysis of recent legal statements on the treatment of refusals to license shows that some of the current confusion and frustration in this area can be attributed to failure to formulate the rules in terms of the economic purposes of the underlying statutes. Some attempts to delineate a boundary between cases in which intellectual property protection is absolute and those in which antitrust restrictions may be imposed are based on logical or semantic distinctions that are not related to the economic issues. These attempts will fail to resolve the confusion.
Mindfulness and the cultural psychology of personhood: Challenges of self, other, and moral orientation in Haiti:

The global spread of mindfulness-based interventions raises some interesting questions regarding the universality and translatibility of key ideas and practices of mindfulness. Based on ethnographi...
Longitudinal relationship between onset of physical symptoms and functional impairment.

Patients with chronic physical symptoms (e.g., chronic pain) often have significant functional impairment (i.e., disability). The fear avoidance model is the dominant theoretical model of how the relationship between chronic physical symptoms and functional impairment develops and proposes a cyclical/bidirectional relationship. There has never been a definitive test of the proposed bi-directional relationship. The current study followed 767 Operation Enduring Freedom/Operation Iraqi Freedom soldiers from pre-deployment, when they were relatively healthy, to 1 year after deployment, when it was anticipated that symptoms would increase or develop. Over the four assessment time points, physical symptom severity consistently predicted worse functional impairment at the subsequent time point. Functional impairment did not show a consistent relationship with worsening of physical symptom severity. These findings suggest that changes to functional impairment do not have a short-term impact on physical symptom severity.
Distribution of m6A in mRNA and its Possible Biological Role

Methylation of cellular and viral mRNA is a common post-transcriptional event whose function is not well understood. Although a role for 5′ terminal methylated cap structures in translation and mRNA stability has been demonstrated (Both et al., 1975), the function of internal methylation of specific adenine residues, to form N6-methyladenosine (m6A), is not clear. It has been suggested that m6A serves some nuclear role in precursor processing and/or transport (Camper et al., 1984) although m6A is not universally found in eukaryotic messages (Perry and Scherrer, 1975; Surrey and Nemer, 1976). The postulated nuclear role for m6A correlates positively with its presence in viral RNAs which spend a portion of their replicative cycle within the nucleus. Internal m6As are found in both cellular and viral mRNAs within the consensus sequence, AG m6AC, (Dimock and Stoltzfus, 1979; Wei et al., 1976) and it has been suggested that these residues may be involved in mRNA precursor splicing (Aloni et al., 1979; Canaani et al., 1979; Chen-Kiang et al ; 1979).
The inflammatory response in focal cerebral ischemia

Inflammation is the reaction of vascularized living tissue to local injury. Local injury is caused by invading microorganisms, radiation, chemical injuries or ischemia. The inflammatory response serves to destroy or contain the infectious or noxious agent and to trigger a series of complex events that repair or replace the damaged tissue. The inflammatory response of any disease, whether it be infectious or ischemic, is highly controlled and any exacerbation of the response can actually harm the organism. Uncontrolled inflammatory reactions can cause chronic disease or death, as illustrated by rheumatoid arthritis or life-threatening hypersensitivity reactions. Occlusion of an artery in the brain causes cerebral ischemic which provokes a well coordinated inflammatory response. The inflammatory response is hypothesized to limit or contain hypoxic damage to a small area. However, as in other inflammatory diseases, the inflammatory response to cerebral ischemia promotes secondary injury to surrounding viable cerebral tissue commonly referred to as the penumbra. This secondary injury or response occurs because of molecular adhesive events, platelet activation, fibrin deposition and cytokine production which occur early after ischemia and reperfusion [1>–5].