cssi/SciSciGPT-SciSciNet huggingface dataset:
Cold pressor test as a marker for the detection of early stage coronary atherosclerosis.

n 7 7 Age (years) 49.66T5.63 51.86T4.03 Sex (male/female) 7/0 7/0 Dyslipidemia, n 5 5 Smoking, n 4 4 Hypertension, n 3 3 Family history, n 3 3 BMI (kg/m) 26.6T1.28 27.3T1.94 Cholesterol (mg/ml) 182.33T16.47 204.0T18.8 Triglycerides (mg/ml) 155.2T20.6 135.2T25.9 HDL (mg/ml) 46.75T8.40 32.00T2.38 Medication Statins 5 5 ACEi 2 2 ARB 1 1 Diuretics 1 0 Endothelial function is suggested to play a key role in the pathophysiology of coronary artery disease [1]. Invasive and non-invasive techniques have been introduced to evaluate endothelium dependent dilatation in response to pharmacological and physical stimuli [2]. Cold pressure test is a useful approach to assess endothelium dependent dilatation [2]. It causes an increased blood pressure and heart rate, inducing NO-mediated vasorelaxation in healthy and vasoconstriction in atherosclerotic arteries [3,4], an effect similar to that seen in response to intraarterial acetylcholine infusion. The purpose of this study was to investigate the sensitivity of reactive hyperaemia and cold pressor testing in peripheral vascular bed to detect patients at the early stage of the coronary atherosclerosis. The protocol of the study was approved by the Ethics Committee and all subjects gave an informed consent. Seven male patients with early stage, newly diagnosed atheromatous arteries (with coronary stenosis <50% in angiography) and seven matched controls with no coronary artery stenosis in angiography were enrolled in the study (Table 1). Forearm blood flow was measured by gaugestrain plethysmography, as we have previously described [2]. All measurements were performed before the angiography, while medication was discontinued for 12 h before the study. The protocol is presented in Fig. 1. Forearm vasodilatory response to reactive hyperemia (RH%) was expressed as the
Addition of Purified Prostate Specific Antigen to Serum from Female Subjects: Studies on the Relative Inhibition by alpha 2-Macroglobulin and alpha 1-Antichymotrypsin

AbstractPurpose: Two forms of prostate specific antigen (PSA), 1 complexed to alpha 1-antichymotrypsin and the other a free PSA, are recognized by current commercially available immunoassays. A third form of PSA complexed to alpha 2-macroglobulin also is present in the serum. To study these 3 different molecular forms of PSA in vivo, we simulated leakage of PSA from the prostate into the serum in vitro.Materials and Methods: Purified seminal fluid PSA was incubated with fresh sera from female subjects at different concentrations. Following gel filtration chromatography, the 3 forms of PSA were studied by immunoassays and Western blot analysis.Results: Using a commercial immunoassay, 60 percent of immunoreactivity of seminal fluid PSA was lost after incubation with sera from female subjects. Western blot analysis showed that most of this loss in PSA signal was caused by complexation to alpha 2-macroglobulin. Minimal, if any, complexation to alpha 1-antichymotrypsin occurred even when excess alpha 1-antichy...
Plasma Reduction of Silver Compounds for Fabrication of Surface-Enhanced Raman Scattering Substrates

Several silver compounds were reduced by low-pressure air plasma to produce porous nanostructured surfaces as surface-enhanced Raman scattering (SERS) substrates. This method is advantageous because substrates are easy to prepare and the silver metal surface is inherently clean without spectroscopic background. Silver compounds were melted into 1–2 mm slugs on quartz slides and plasma treated for different lengths of time. Silver chloride was found to be the best compound to make reproducible and stable SERS substrates. SERS activity of the substrates was tested using L-tryptophan, 4-mercaptobenzoic acid, and adenine.
Nonlinear mappings of monotone type in Banach spaces

Abstract A new class of (nonlinear) operators of monotone type is introduced: a mapping T from the real Banach space X into the set 2 X ∗ of all subsets of the conjugate space X ∗ is said to be generalized pseudo-monotone if for any sequence { u j } in the effective domain of T with u j ⤳u in X and any corresponding sequence w j ⤳w in X ∗ , w j ϵ Tu j , for which lim sup( w j − w , u j − u ) ⩽ 0, it follows that w ϵ Tu and ( w j , u j ) → ( w , u ). It is shown that most of the known mappings of monotone type are generalized pseudo-monotone, as, for example, maximal monotone and pseudo-monotone mappings. The class of generalized pseudo-monotone mappings is then investigated in detail. An important part of that study is devoted to the discussion of the range of a generalized pseudo-monotone mapping.
Environmental conditions and their impact on immunocompetence and pathogen susceptibility of the Caribbean termite Nasutitermes acajutlae

1. Little is known about interactions between environmental conditions surrounding insects and their immune responses. 2. The environment in and around termite colonies, including temperature, relative humidity, soil pH, and light was analysed using principal components analysis (PCA). 3. The relationship between these abiotic parameters and two aspects of termite immunity (phenoloxidase activity and lipid content) was examined in field-caught workers of Nasutitermes acajutlae Holmgren. Finally, termites from warm/dry and cool/moist habitats were exposed to Metarhizium anisopliae to determine their susceptibility to mycosis. 4. PCA indicated that environmental components external to the nest [ambient temperature, ambient relative humidity (RH), soil temperature and light] comprised the majority (PC1 = 37.5%) of variation. Internal variables (nest temperature and RH) and nest volume accounted for 19.6% (PC2) of the variation with pH comprising 12.9% (PC3). 5. AIC and regression models suggested that ambient temperature was most strongly and positively associated with immune variables and that relative humidity may also play a role. Termites from warm/dry colonies were less susceptible to M. anisopliae than termites from cool/moist colonies. 6. Thus, termites nesting in warmer habitats may exhibit increased immune-related measures and reduced susceptibility to mycosis compared with termites from cooler habitats.
Superharmonic injection locked oscillators as low power frequency dividers

Superharmonic injection locking is investigated in a new theoretical approach. Low power frequency dividers are designed using injection locked oscillators with cascode transistors. The Rockwell 0.5 /spl mu/m CMOS process is used to design a 3 mW injection locked frequency divider in the 1800 MHz frequency range. A 200 MHz maximum locking range is achieved in simulations. 2SC3302 Toshiba NPN transistors are also used to build a 1.75 mW injection locked frequency divider in the 800 MHz frequency range to verify the theory.
Channel formation by flow stripping: large‐scale scour features along the Monterey East Channel and their relation to sediment waves

The Monterey East system is formed by large-scale sediment waves deposited as a result of flows stripped from the deeply incised Monterey fan valley (Monterey Channel) at the apex of the Shepard Meander. The system is dissected by a linear series of steps that take the form of scour-shaped depressions ranging from 3·5 to 4·5 km in width, 3 to 6 km in length and from 80 to 200 m in depth. These giant scours are aligned downstream from a breech in the levee on the southern side of the Shepard Meander. The floor of the breech is only 150 m above the floor of the Monterey fan valley but more than 100 m below the levee crests resulting in significant flow stripping. Numerical modeling suggests that the steps in the Monterey East system were created by Froude-supercritical turbidity currents stripped from the main flow in the Monterey channel itself. Froude-supercritical flow over an erodible bed can be subject to an instability that gives rise to the formation of cyclic steps, i.e. trains of upstream-migrating steps bounded upstream and downstream by hydraulic jumps in the flow above them. The flow that creates these steps may be net-erosional or net-depositional. In the former case it gives rise to trains of scours such as those in the Monterey East system, and in the latter case it gives rise to the familiar trains of upstream-migrating sediment waves commonly seen on submarine levees. The Monterey East system provides a unique opportunity to introduce the concept of cyclic steps in the submarine environment to study processes that might result in channel initiation on modern submarine fans.
Anchoring Relationships at Work: Mentors as Buffers to Ambient Racial Discrimination

Our study tested the “mentors as buffers hypothesis,” which holds that the presence of a mentor can buffer employees from the detrimental effects of a discriminatory workplace. Using a sample of 3,813 workers, we found that mentors can buffer employees from the negative effects of ambient racial discrimination. However, we also found that the type of mentor and the quality of the relationship mattered. Employees who witnessed or were exposed to racial discrimination at work had less organizational commitment than those not exposed, but those with informal mentors or high quality formal relationships experienced less loss of commitment than those lacking a mentor. Mentors may also be uniquely situated to buffer employees from the negative effects of a discriminatory workplace; buffering effects were not found for supportive supervisors or coworkers. These findings suggest that mentoring may be a unique anchoring relationship that helps employees maintain their commitment in the face of workplace discrimina...
Active learning in the online environment: The integration of student-generated audio files

Educators have integrated instructor-produced audio files in a variety of settings and environments for purposes such as content presentation, lecture reviews, student feedback, and so forth. Few i...
Visions of the Emerald City: Modernity, Tradition, and the Formation of Porfirian Oaxaca, Mexico – By Mark Overmeyer‐Velázquez

The dictatorship of General Porfirio Diaz [1877–1911] in Mexico sought to modernize the nation's economy and society. In Visions of the Emerald City, Mark Overmeyer‐Velazquez argues that profound t...
Discrete Advanced Guidance for High Order Acceleration Constrained Missile

An explicit closed form formula of a discrete guidance law for a linear, time-invariant, high-order and acceleration-constrained missile is presented. The formula is given in terms of the missile transfer function and acceleration constraint, and responses to initial conditions.
Introduction to the Special Issue: Posttraumatic Stress Related to Pediatric Illness and Injury

doi:10.1093/jpepsy/jsj052 Advance Access publication August 3, 2005 Journal of Pediatric Psychology vol. 31 no. 4 © The Author 2005. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oupjournals.org Introduction to the Special Issue: Posttraumatic Stress Related to Pediatric Illness and Injury
Synthesis and Assessment of CO-Release Capacity of Manganese Carbonyl Complexes Derived from Rigid α-Diimine ­Ligands of Varied Complexity

Four manganese carbonyl complexes of the type [MnBr(CO)3(NN)] (NN = α-diimine ligands): namely [MnBr(CO)3(bpy)] (1), [MnBr(CO)3(phen)] (2), [MnBr(CO)3(dafo)] (3), and [MnBr(CO)3(pyzphen)] (4) (where bpy = bipyridine, phen = 1,10-phenanthroline, dafo = 4,5-diazafluoren-9-one, and pyzphen = pyrazino[2,3-f][1,10]-phenanthroline) have been synthesized and structurally characterized. These four complexes, each containing the fac-[Mn(CO)3] motif, release CO upon illumination with low-power visible and UV light. The CO release rates and the absorption maxima of the complexes are, however, very similar, despite the systematic increase in structural complexity in the rigid α-diimine ligand frameworks. This contrasts strongly with manganese carbonyl complexes derived from α-diimine ligands in which at least one of the imine functions is not part of a rigid ring system. The results of this study should provide help in the future design of ligand frameworks suitable for the syntheses of photoCORMs to deliver CO to biological targets under the control of light.
Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma

The Hedgehog (Hh) signaling pathway is aberrantly activated in a wide variety of human cancers, and recent clinical studies have demonstrated that pathway inhibitors are effective in advanced basal cell carcinoma (BCC). The majority of these agents have been designed to target SMOOTHENED (SMO), a transmembrane regulator of Hh signaling, but subsequent mutations in SMO have been found to generate drug resistance. In other cancers, oncogenic events that bypass SMO may activate canonical Hh signaling, and SMO antagonists have not demonstrated significant activity in several diseases. Therefore, alternative strategies targeting the Hh pathway downstream of SMO may have clinical utility. Liver X Receptors (LXRs) regulate cholesterol and fatty acid homeostasis, and LXR activation can inhibit the Hh pathway in normal mouse embryonic fibroblasts. We examined the effects of LXR activation on Hh signaling in human multiple myeloma (MM) cells and found that LXR agonists inhibited Hh pathway activity and clonogenic tumor growth in vitro. LXR activation also inhibited putative MM cancer stem cells in vivo leading to the loss of tumor initiating and self-renewal potential. Finally, Hh signaling was inhibited downstream of SMO, suggesting that LXR agonists may represent a novel strategy to target pathogenic Hh signaling as well as treat MM.
On the Finite-Sample Accuracy of Nonparametric Resampling Algorithms for Economic Time Series

In recent years, there has been increasing interest in nonparametric bootstrap inference for economic time series. Nonparametric resampling techniques help protect against overly optimistic inference in time series models of unknown structure. They are particularly useful for evaluating the fit of dynamic economic models in terms of their spectra, impulse responses, and related statistics, because they do not require a correctly specified economic model. Notwithstanding the potential advantages of nonparametric bootstrap methods, their reliability in small samples is questionable. In this paper, we provide a benchmark for the relative accuracy of several nonparametric resampling algorithms based on ARMA representations of four macroeconomic time series. For each algorithm, we evaluate the effective coverage accuracy of impulse response and spectral density bootstrap confidence intervals for standard sample sizes. We find that the autoregressive sieve approach based on the encompassing model is most accurate. However, care must be exercised in selecting the lag order of the autoregressive approximation.
The Effect of Phenothiazine upon Thyroid Function in Dairy Animals as shown by Radioiodine

Summary Commercial phenothiazine, when administered at the rate of 2g. per day to dairy heifers, reduced the uptake of I 131 but did not induce hypothyroidism, as shown by the release rates of thyroid hormone from the gland. Thus at the dosage administered phenothiazine does not act as a goitrogenic agent.
On the orbits of an orthogonal group action

Let G be the Lie group SO(n,R)× SO(n,R) and let V be the vector space of n× n real matrices. An action of G on V is given by (g, h).v := g−1vh, (g, h) ∈ G, v ∈ V . We consider the orbits of this group action and demonstrate a cross-section to the orbits. We then determine the stabilizer for a typical element in this crosssection and completely describe the fundamental group of an orbit of maximal dimension.
Defect Chemistry of Donor‐Doped BaTiO3

Donor additions to BaTiO3 up to a few tenths atom percent are compensated by electrons and the resulting electrical conductivity is independent of temperature and Po2 at 700° to 1000°C. The conductivities are impurity-insensitive at very low Poz and high temperature where reduction is the major source of defects. Variation in the site occupation ratio (A/B in ABO3 has a small effect on the conductivities for donor additions in the 100 ppm range. Nb is more effective as a donor than is Al as an acceptor, and Nb can compensate approximately 2½ times as much Al on an atomic basis.
Overcoming socio-economic barriers to conservation subdivisions: A case-study of four successful communities

a b s t r a c t Conservation subdivisions have emerged as an option to conserve open space, protect water quality and wildlife habitat, and maintain scenic views without compromising property rights. Despite eco- nomic and ecological advantages over traditional subdivisions, conservation subdivisions remain rare. We used a mixed-method study combining a survey of 246 people who attended conservation subdivision workshops with a qualitative case study of four communities that successfully developed conservation subdivisions to identify potential barriers to conservation subdivisions and strategies to overcome those barriers. A principal component analysis based on survey respondent rankings grouped barriers into: resistance to change among stakeholders, concerns about differences between traditional subdivisions and conservation subdivisions, concerns about consumer demand, and misperceptions about construc- tion costs. Survey respondents indicated the top barrier to completion of conservation subdivisions was lack of incentives for developers. The case study communities overcame resistance from developers and landowners through educational efforts including informal meetings, charrettes, and workshops focus- ing on the environmental and economic benefits of conservation subdivisions. The communities had support from elected officials, and planning staff devoted necessary resources to rewrite ordinances, review sketch plans, and perform site visits. To overcome barriers to conservation subdivisions, commu- nities could provide incentives including density bonuses and expedited approval processes. Encouraging participation in workshops and design charrettes for proposed developments may alleviate concerns of landowners who perceive a loss of property rights from new regulations and aid in the acceptance of conservation subdivisions. © 2012 Elsevier B.V. All rights reserved.
Random pattern testability of memory address logic

An analytical method is described for determining the random pattern testability of faults in combinational logic feeding the address inputs of embedded memories. Difference information from replicated copies of embedding logic is used to determine the probability of detecting any fault in the upstream of either a read or write port address decoder. The method can be used with minor extensions to existing detection probability tools such as the cutting algorithm.
Health Monitoring of the Aircraft Structure during a Full Scale Fatigue Test with Use of an Active Piezoelectric Sensor Network

The paper presents an approach to develop a system for fatigue crack growth monitoring and early damage detection in the PZL – 130 ORLIK TC II turbo-prop military trainer aircraft structure. The system functioning is based on elastic waves propagation excited in the structure by piezoelectric PZT transducers. In the paper, a built block approach for the system design, signal processing as well as damage detection is presented. Description of damage detection capabilities are delivered in the paper and some issues concerning the proposed signal processing methods and their application to crack growth estimation models are discussed. Selected preliminary results obtained during the Full Scale Fatigue Test thus far are also presented.
Leveraging Identity-Based Cryptography for Node ID Assignment in Structured P2P Systems

Structured peer-to-peer systems have grown enormously because of their scalability, efficiency and reliability. These systems assign a unique identifier to each user and object. However, current assignment schemes allow an adversary to carefully select user IDs and/or simultaneously obtain many pseudo-identities-leading ultimately to an ability to disrupt the P2P system in very targeted (and dangerous) ways. In this paper, we propose novel ID assignment protocols based on identity-based cryptography. This approach permits the acquisition of node IDs to be tightly regulated without many of the complexities and costs associated with traditional certificate solutions. We broadly consider the security requirements of ID assignment and present three protocols representing distinct threat and trust models. A detailed empirical study of the protocols is given. Our analysis shows that the cost of our identity-based protocols is nominal, and that the associated identity services can scale to millions of users using a limited number of servers.
Breeding Ecology of Greater Prairie-chickens (Tympanuchus cupido) in Relation to Prairie Landscape Configuration

Abstract To better understand the role of prairie landscape configuration on the population dynamics and conservation of greater prairie-chickens, we compared population trends and breeding ecology of prairie-chickens in prairie mosaic and contiguous prairie landscapes in southwestern Missouri. Over 27 yr, the contiguous prairie landscape supported a stable population, whereas the prairie-chicken population in the prairie mosaic landscape declined. In 1986 and 1987, less than one-third of greater prairie-chicken nests occurred in native prairie habitats in the prairie mosaic landscape, but 90% of nests in the contiguous prairie area were in native prairie. Greater prairie-chicken nests established in agricultural habitats had substantially lower nest success than nests in native prairie or mixed native-exotic grass pastures. Nest success was higher in the contiguous prairie landscape than in the prairie mosaic area in 1 of 2 yr. Habitat use by broods differed between the areas: in the contiguous prairie l...
Flow Visualization of the Motions of Elastomers and Molten Plastics in an Internal Mixer

Abstract A basic study of flow visualization of motions of elastomers in a model internal mixer with Banbury rotors has been presented. The behavior of butadienestyrene copolymers (SBR), cis-polybutadiene (BR), natural rubber (NR), and various molten plastics has been investigated. The SBR's and BR behave similarly, exhibiting tearing when stretched by the moving rotor tip away from the bridge in the mixer. This results in large stagnant regions between the bridge and ram in the mixer. The NR does not tear but stretches out when the rotor tip pulls it around the rotor circumference. At low fill factors, the NR bands about the rotors. Studies of molten plastics including low density, high density polyethylene and polystyrene are also reported. Longitudinal motions of rubber on the rotors have been investigated.
Frito-Lay North America: The Making of a Net Zero Snack Chip

Implementing a sustainability strategy requires firms to consider economic, strategic, environmental, and community perspectives. Suitable for MBA, undergraduate, and executive learners, this sustainability case covers innovation, intrapreneurship, and strategy. An Excel carbon footprint analysis exercise (UVA-S-ENT-0112) accompanies the case; a technical note entitled, "Corporate Greenhouse Accounting: Carbon Footprint Analysis" (UVA-ENT-0113) is an effective complement. Frito-Lay’s Arizona facility pilots a program to take its snack chip manufacturing off the grid. Decision makers discuss operating, financial, marketing, and corporate strategy as the facility calculates its carbon footprint, converts to non-fossil-fuel energy sources, and stops relying on the scarce local water supply.
Dreaming of Robots: An Interview About Robots with Bruce Sterling

In past times, not only today, human beings have dreamed of “human-machine” hybrids, which, or who, could help, hurt, collaborate with, and/or challenge us.
Compositional changes in

The compositional changes in Al-Li-(Mg)-(Cu) alloys induced by oxidation at high temperature (450 °C to 570 °C) were investigated by secondary ion mass spectrometry (SIMS). It was found that the alloy surface beneath the oxide layer was depleted in both Li and Mg as a consequence of the selective oxidation of these elements, whereas Cu concentration was nearly constant or slightly increased in the affected zone. The measured-concentration profiles of Li and Mg were modeled using a diffusion equation to obtain diffusion data for the alloys. The depletion profiles also provided information regarding the interfacial-alloy composition and the depletion depth. The effect of alloying elements on the oxidation and depletion behavior is discussed. Secondary ion mass spectrometry data were quantified using the relative sensitivity factor method, and the quantification procedure is described in detail.
Molecular physiology of renal ClC chloride channels/transporters.

Purpose of reviewRecent findings relevant to the renal ClC chloride channels/transporters are reviewed with a focus on structure–function relationships, regulation of trafficking, role in blood pressure control, and pharmacology.Recent findingsThe ClC proteins include plasma membrane Cl− channels an
The Regulation of Hematopoietic Growth Factor Production from Cord Mononuclear Cells and Its Effect on Newborn Rat Hematopoiesis

Newborns are characterized by significant developmental immaturities in hematopoiesis and phagocytic immunity. Defects in myelopoiesis and thrombopoiesis predispose newborns to peripheral cytopenia...
Sports-Related Posttraumatic Migraine

Symptoms and neurocognitive functioning were compared in athletes with no headache (non-HA group), athletes complaining of HA (HA group), and athletes with posttraumatic migraine (PTM group), in a study of 261 high school and college athletes (mean age, 16.36+/-2.6 years) at University of Pittsburgh Medical Center; University of North Carolina, Chapel Hill; and Florida Neuroscience Institute, Orlando.
Clinician effectiveness in assessing fitness to drive of medically at-risk older adults

OBJECTIVES: To model the relative contributions of driver data and clinical judgments to clinical ratings of driver capability for a state licensing authority and to compare ratings with on-road test results. DESIGN: Retrospective, logistic regression. SETTING: Missouri Driver License Bureau. PARTICIPANTS: Adults aged 60 and older (N = 652; 52% male) evaluated by a physician of their choosing and a portion subsequently road tested (n = 286). MEASUREMENTS: Clinical data from an evidence-based physician statement (Form 1528). A three-level rating (likely capable, unclear, not capable) was collapsed into two outcomes (0 likely capable; 1 unclear, not capable) as the dependent variable. Independent variables (predictors) were age, sex, driving exposure, recent crash or police action, number of medical conditions, medication side effects, driver insight, and disease functional severity rating for driving. RESULTS: Three variables in the model (Nagelkerke coefficient of determination = 0.64; P CONCLUSION: Judgments of disease severity, decrements in driver insight, and older age influenced clinician ratings of driving capability. Correspondence of physician ratings to on-road test outcomes was imperfect, highlighting the complexities in translation of clinical judgments to on-road performance. Both means of assessment have important and additive roles in driver licensing.© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society. Language: en
The Hemodynamic Hole

This case discusses multiple cumulative pharmacodynamic interactions between general and neuraxial anesthetics, angiotensin converting enzyme inhibitors and angiotensin receptor blockers, resulting in significant intraoperative hypotension.
An Amino Acid Code for the Rational Design and Investigation of Protein Packing Structure using the knob-socket Model

The applications of protein design are limited by the ability to determine a protein's fold and function based solely on a given amino acid sequence. The novel knob-socket model accurately classifies protein tertiary packing structure and provides a code that aims to accurately describe the packing interactions of side-chain residues. It is able to classify protein structure based on distinct amino acid side-chain preferences, which then predict the knob-socket arrangement of the packed protein. From the frequency of appearance in known structures, the knob-socket model provides the basis for prediction of stabilizing and destabilizing mutations. This model was used to design a 27 amino acid sequence, KSalpha1.1, which has been shown to fold into a stable alpha-helix configuration and that oligomerizes. The effects of helix stability are characterized with CD spectroscopy and oligomerization with NMR. Using known correlations of amino acid composition to alpha-helix propensity from the knob-socket model specific amino acids in the KSalpha1.1 sequence are changed to predictively strengthened or weakened packing stability. Current work involves purification and characterization of these mutations in the KSalpha1.1 protein to demonstrate the accuracy of the knob-socket model for protein design. The results provide further proof of knob-socket's ability to correctly model the packing in protein structure and serve as a fundamental descriptor of higher order protein structure.
Corporeality and cultural rhetoric: A site for rhetoric's future

Instead of taking each essay on its own terms in fashioning a response, I will, in what follows, advance an argument with respect to the central question I see emerging from these essays: If rhetoric is to re‐fashion itself in responding to a culturally diverse world, what kind of theoretical orientation might it find as its “site” from which to appraise rhetoric?
Case 4: Two Black Eschars in a 6-year-old Girl

1. Zachary Graff, MD* 2. Geronimo Mendoza, MD* 3. Apurv Barche, MD* 4. Curtis Turner, MD* 1. *Texas Tech University Health Sciences Center School of Medicine, Amarillo, TX. A previously healthy 6-year-old Hispanic girl presents with a 4-week history of a left lower back skin lesion and a 1-week history of a left forearm lesion. Both lesions progressed from an initial red bump to ulceration with overlying black crust. The lesions are mildly itchy and not painful. She denies fever, weight loss, night sweats, lymphadenopathy, and cough. She has no history of trauma, international travel, tuberculosis exposure, pet bites or scratches, or exposure to animal hides. There is no family history of cancer. Social history is notable for her father working at a dairy farm. Physical examination reveals a temperature of 36.2°C (97.2°F), with other vital signs within normal limits. The girl is smiling and cooperative. Examination of the skin reveals a nontender 2.5 × 2-cm sharply defined ulcer with overlying black eschar on the left lower back with edematous and erythematous borders (Fig 1) and a similar 1-cm lesion on the left forearm (Fig 2). There is no clinically significant lymphadenopathy or hepatosplenomegaly. The remainder of the examination yields normal results. Figure 1. A 2.5 × 2.0-cm sharply defined ulcer with overlying black eschar on the left lower back with edematous and erythematous borders. Figure 2. A …
Implementing an Advance Care Planning Intervention in Community Settings with Older Latinos: A Feasibility Study

Abstract Background: Older Latinos with serious medical conditions such as cancer and other chronic diseases lack information about advance care planning (ACP). ACP Intervention (ACP-I Plan) was designed for informational and communication needs of older Latinos to improve communication and advance directives (ADs). Objective: To determine the feasibility of implementing ACP-I Plan among seriously ill, older Latinos (≥50 years) in Southern New Mexico with one or more chronic diseases (e.g., cancer, heart disease, renal/liver failure, stroke, hypertension, diabetes, chronic obstructive pulmonary disease, and HIV/AIDS). Design: We conducted a prospective, pretest/post-test, two-group, randomized, community-based pilot trial by using mixed data collection methods. Setting/Subjects: Older Latino/Hispanic participants were recruited from community-based settings in Southern New Mexico. Methods: All participants received ACP education, whereas the intervention group added: (1) emotional support addressing psych...
Ultrafast room-temperature single photon source with plasmonic nanocavities

A single quantum dot coupled to a metallic cavity acts as a directional, efficient, and ultrafast single photon source with a spontaneous emission lifetime of 13 ps, corresponding to a Purcell factor of 540.
Reentrant metallic behavior in the Weyl semimetal NbP

We report the occurrence of reentrant metallic behavior in the Weyl semimetal NbP. When the applied magnetic field $H$ is above a critical value ${H}_{\mathrm{c}}$, a reentrance appears as a peak in the temperature-dependent resistivity ${\ensuremath{\rho}}_{xx}(T)$ at $T={T}_{\mathrm{p}}$, similar to that observed in graphite where it was attributed to local superconductivity. The ${T}_{\mathrm{p}}(H)$ relationship follows a power-law dependence ${T}_{p}\phantom{\rule{0.28em}{0ex}}\ensuremath{\sim}{(H\ensuremath{-}{H}_{c})}^{1/\ensuremath{\nu}}$ where \ensuremath{\nu} can be derived from the temperature dependence of the zero-field resistivity ${\ensuremath{\rho}}_{0}(T)\ensuremath{\sim}{T}^{\ensuremath{\nu}}$. From concurrent measurements of the transverse ${\ensuremath{\rho}}_{xx}(T)$ and Hall ${\ensuremath{\rho}}_{xy}(T)$ magnetoresistivities, we reveal a clear correlation between the rapidly increasing ${\ensuremath{\rho}}_{xy}(T)$ and the occurrence of a peak in the ${\ensuremath{\rho}}_{xx}(T)$ curve. Quantitative analysis indicates that the reentrant metallic behavior arises from the competition of the magnetoconductivity ${\ensuremath{\sigma}}_{xx}(T)$ with an additional component $\mathrm{\ensuremath{\Delta}}{\ensuremath{\sigma}}_{xx}(T)={\ensuremath{\kappa}}_{H}{\ensuremath{\sigma}}_{xx}(T)$ where ${\ensuremath{\kappa}}_{H}={[{\ensuremath{\rho}}_{xy}(T)/{\ensuremath{\rho}}_{xx}(T)]}^{2}$ is the Hall factor. We find that the Hall factor (${\ensuremath{\kappa}}_{H}\ensuremath{\approx}0.4$) at peak temperature ${T}_{\mathrm{p}}$ is nearly field independent, leading to the observed ${T}_{p}(H)$ relationship. Furthermore, the reentrant metallic behavior in ${\ensuremath{\rho}}_{xx}(T)$ also is reflected in the behavior of ${\ensuremath{\rho}}_{xx}(H)$ that ranges from nonsaturating at $Tg70\phantom{\rule{0.16em}{0ex}}\mathrm{K}$ to saturation at liquid-helium temperatures. The latter can be explained with the magnetic field dependence of the Hall factor ${\ensuremath{\kappa}}_{H}(H)$. Our paper demonstrates that a semiclassical theory can account for the ``anomalies'' in the magnetotransport phenomena of NbP without invoking an exotic mechanism.
Medical renal diseases are frequent but often unrecognized in adult autopsies

Kidney diseases affect many hospitalized patients and contribute to morbidity and mortality. Therefore, kidney disease should be prevalent, but the frequency and spectrum of medical renal pathology in autopsy specimens has not been well documented. We sought to determine the spectrum of medical renal pathology in adult autopsy specimens and the frequency of overlooked diagnoses. We reviewed the hematoxylin- and eosin-stained kidney sections from 140 adult autopsies performed at a large teaching hospital over a 2-year period. Fifty-eight cases (41%) had findings warranting further analysis, including alterations in glomerular matrix and/or cellularity, atypical or pigmented casts, thrombi, tubulointerstitial or vascular inflammation, or deposition of amorphous material. After additional studies and clinical correlation, the pathologic changes in 43 cases (31%) were categorized as follows: diabetic nephropathy, bile cast nephropathy, thrombotic microangiopathy, infection-related glomerulonephritis, focal necrotizing/crescentic glomerulonephritis, oxalate nephropathy, light-chain cast nephropathy, amyloidosis, urate nephropathy, hemosiderosis, antineutrophil cytoplasmic antibody-associated vasculitis, polyoma virus nephropathy, atheroembolic disease, and nephrocalcinosis. These diagnoses were not reported in 26 (60%) cases during the initial autopsy evaluation. This study demonstrates that medical renal diseases are common in autopsy cases, but significant diagnoses can be easily overlooked. Autopsy kidney specimens are a rich source of renal pathology and their evaluation should be emphasized in anatomic pathology residency training. Ultimately, our understanding of how kidney disease contributes to morbidity and mortality will benefit from accurate recognition of renal pathology in autopsy specimens.
Dose Accuracy, Injection Force, and Usability Assessment of a New Half-Unit, Prefilled Insulin Pen:

Background:This study examines the utility of the first prefilled, rapid-acting insulin pen that can be dialed in half-unit increments. Dose accuracy and injection force were examined through a ser...
Ethical Healthcare Agents

We have combined a bottom-up casuistry approach with a top-down implementation of an ethical theory to develop a system that uses machine-learning to abstract relationships between prima facie ethical duties from cases of particular types of ethical dilemmas where ethicists are in agreement as to the correct action. This system has discovered a novel ethical principle that governs decisions in a particular type of dilemma that involves three potentially conflicting prima facie duties. We describe two prototype systems in the domain of healthcare that use this principle, one that advises human beings as to the ethically correct action in specific cases of this type of dilemma and the other that uses this principle to guide its own behavior, making it what we believe may be the first explicit ethical agent.
Therapeutic Effectiveness of Neuraminidase-Treated Allogeneic Myeloblasts as Immunogen in Acute Myelocytic Leukemia

Our chemoimmunotherapy study shows significantly longer remission and survival in acute myelocytic leukemia (AML) patients who have been immunized with neuraminidase-treated allogeneic myeloblasts as compared to patients who received chemotherapy alone or neuraminidase-treated myeloblasts plus MER. MER impairs the immunotherapeutic effectiveness of neuraminidase-treated allogeneic myeloblasts in AML patients. The in vivo and in vitro immunologic status in each arm of the protocol correlate well with the duration of remission and survival of the patient.
Localized to Itinerant Electronic Transitions in Perovskite-Related Structures

Experiments on several perovskite-related transition-metal oxides at the cross-over from localized to itinerant electronic behavior reveal strong electron coupling not only to static, but also to dynamic oxygen displacements. A discontinuous change in the mean kinetic energy of the electrons results in a first-order transition at the cross-over and a breakdown of the Brinkman-Rice strong-correlation model before long-range magnetic order is stabilized. The superconductive copper oxides appear to stabilize a distinguishable thermodynamic state below a T l ≈ 300 K where a multicenter polaron gas condenses into a polaron liquid that progressively orders into mobile stripes as the temperature is lowered to Tc. It is suggested that itinerant vibronic states are formed as a result of coupling of itinerant electrons to dynamic oxygen displacements along the Cu-O bond axes in the mobile stripes. Such vibronic states would be responsible for a remarkable transfer of spectral weight to states propagating parallel to the bond axes. The transfer of spectral weight is responsible for the anisotropy of the superconductive gap and an enhancement of the thermoelectric power in the interval Tc < T < T l that is uniquely associated with the high- Tc superconductive phenomenon.
Change in the Psychological Adjustment of Children with Cystic Fibrosis or Sickle Cell Disease and Their Mothers

Objectives: This study has three interrelated objectives: (1) to track the adjustment of children and adolescents with sickle cell disease (SCD) or cystic fibrosis (CF) and their mothers through a third assessment point 2 years after the initial assessment; (2) to determine whether the adaptational processes of the transactional stress and coping model associated with adjustment at the initial assessment continue to be associated with adjustment 2 years later; and (3) to determine whether the pattern of association of adaptational processes with adjustments differs by illness subgroup. Methods: The study samples included 59 children with CF and 50 children with SCD and their mothers. Measures were obtained on maternal adjustment and appraisals of daily and illness stress, coping methods, and family functioning. Child measures included child-reported and mother-reported child adjustment and child perceptions of self-worth and health locus of control and pain coping methods. Results: Consistency in adjustment classification was only 31–32% for child self-report, 66% for mother-reported child behavior problems, and 56–77% for mother self-reported adjustment for the CF and SCD groups, respectively. Support was provided for the association of adaptational processes with maternal adjustment and with the adjustment of children with SCD but not for children with CF. Conclusion: The stability of adjustment has implications for prevention and treatment intervention and subsequent research steps. Intervention efforts should be focused on the relatively small subgroups of children with chronic illnesses and their mothers with consistently poor adjustment.
Energy and Energy Safety in the Operating Room

Since Cushing and Bovie introduced the use of the electricity to facilitate coagulation in 1926 [1], the use of energy has become a vital component of modern-day operating. This is particularly true in laparoscopic surgery, where our quest to eliminate incisions, while improving efficiency, has led to the development of a variety of energy devices that can seal and divide tissue.
STRUCTURE AND FUNCTIONS OF ARTHROPOD PROTEASOMES

Recent work on structural/functional relationships in arthropod proteasomes is reviewed. Taking advantage of our ability to induce a stable, proteolytically-active conformation of the lobster proteasome, the structures of basal and heat-activated complexes were probed with exogenous proteases. Increased sensitivity to chymotrypsin and trypsin showed that heat activation induced a more 'open' conformation, allowing entry of large substrates into the catalytic chamber. In Drosophila, the effects of two developmental mutant alleles (DTS-7 and DTS-5) encoding proteasome subunits (Z and C5, respectively) on the subunit composition and catalytic activities of the enzyme were examined. Both qualitative and quantitative differences in compositions between wild-type (+/+) and heterozygotes (+/DTS) indicated that incorporation of mutant subunits alters post-translational modifications of the complex. Catalytic activities, however, were similar, which suggests that the developmental defect involves other proteasome properties, such as intracellular localization and/or interactions with endogenous regulators. A hypothetical model in which DTS subunits act as poison subunits is presented.
Four independent predictors of postoperative seizures after meningioma surgery: a meta-analysis

Background Postoperative seizures after surgical resection of intracranial meningiomas will negatively affect the quality of life of patients. The aim of the present meta-analysis was to pool the current data and identify the independent predictors of postoperative seizures to better guide postoperative surveillance. Methods Searches of 4 electronic databases from inception to February 2019 were conducted using the preferred reporting items for systematic reviews and meta-analyses guidelines. We identified 430 reports for screening. The hazard ratios (HRs) of the preoperative and postoperative parameters from ≥3 separate multivariate regression analyses were pooled using a meta-analysis of the proportions. Results Of the 430 reports, 12 satisfied the criteria for inclusion in the present study. The pooled population of 5681 patients with meningioma had a median age of 56 years (range, 50–61) and a median proportion of World Health Organization grade I of 91% (range, 66–100). From these data, 4 statistically significant, independent predictors of postoperative seizures were identified: 1) preoperative seizure history (HR, 3.53; P Conclusions We identified 4 significant independent predictors of postoperative seizures after meningioma resection. These parameters should be considered in the follow-up of these patients to ensure optimal seizure surveillance, although ultimate validation by prospective studies is still required.
Nativity, Neighborhoods, and Body Composition in the Sacramento Area Latino Study on Aging

BACKGROUND AND OBJECTIVES Globally, obesity influences the risk of many major chronic diseases. Our study examines the association between individual nativity and neighborhood level concentration of immigrants with 10-year changes in weight, body mass index (BMI), and waist circumference (WC) among older Latinos. RESEARCH DESIGN AND METHODS The Sacramento Area Latino Study on Aging (SALSA) is a population-based prospective study of community-dwelling older adults of Mexican origin (baseline ages 58-101 years). The primary outcome was repeated measures of weight over a 10-year period for 1,628 respondents. Nativity was defined by participants' reported place of birth (US-born or Latin American foreign born). Neighborhood immigrant concentration was measured as the percentage of foreign born at census tract level (2000 US Census). We used linear mixed models with repeated measures of weight, height, BMI, and WC as dependent variables (level 1), clustered within individuals (level 2) and neighborhood migrant concentration (level 3). RESULTS Foreign born (FB) respondents had lower baseline weight than the US-born (mean, 160 vs. 171 lbs, p < .0001). Over time, weight differences between the FB and the US-born decreased by 1.7 lbs/5 years as US-born weight decreased more rapidly. We observed a significant interaction between individual nativity and neighborhood immigrant concentration (p = .012). We found similar patterns for BMI, but did not find statistically significant differences in WC trajectories. DISCUSSION AND IMPLICATIONS Our study observed significant differences by foreign born vs. US nativity in baseline weight/BMI and in their trajectories over time. Additionally, we found weight/BMI differences in neighborhood immigrant concentration for the FB, but not for the US-born.
Fluorescence In Situ Hybridization for the X and Y Chromosome Centromeres Helps Differentiate Between Gestational and Nongestational Choriocarcinoma in Clinically Ambiguous Cases

Context.— Gestational choriocarcinoma usually presents during the reproductive years, typically within 1 year of pregnancy, although presentation remote from pregnancy also occurs and may cause con...