cssi/SciSciGPT-SciSciNet huggingface dataset:
Preliminary Investigation of Effects of Seawater pH on Early Development of Limulus polyphemus

Estuarine organisms are exposed to periodic strong fluctuations in seawater pH driven by natural O2/CO2 biogeochemical cycles. The average pH of ocean surface waters has decreased by about 0.1 units from 8.2 to 8.1, since the beginning of the industrial revolution. This phenomenon, dubbed ocean acidification, may be exacerbated into the future by increasing atmospheric CO2 from fossil fuel combustion and associated land use changes. The direct biological effect of ocean acidification is not well understood and may vary among organisms. In a preliminary investigation to detect the sensitivity of Limulus polyphemus to pH changes, sets of 100 fertilized eggs were exposed to five isolated systems with pH values ranging from 6.0 to 8.0 for 4 weeks. This preliminary investigation chronicled the effects of pH on larval and/or juvenile carapace length and the development to the post-larval juvenile stage over time. Trends in carapace length (without telson) for larva and juveniles (with telson), measured by scanning electron microscopy (SEM), were positively correlated to pH within the experimental range. The long-term consequences of ocean acidification on early stage horseshoe crab development are unknown, and this work prompts further investigation.
Nonpolar GaN films on high-index silicon: Lattice matching by design

We explore theoretically the possibility of growing GaN films in a nonpolar orientation on planar high-index Si($hhk$) substrates. Candidate substrates were identified by requiring that they are well lattice matched, on a length scale of several unit cells, to GaN in the nonpolar $m$-plane orientation. These candidate orientations were then used to construct atomistic models of the GaN/Si($hhk$) interface. Using density functional theory, we then computed the formation energies of these nonpolar interfaces and compared them to those of competing polar interfaces. We find that Si(112) and Si(113) offer potentially favorable substrates for the growth of nonpolar $m$-plane GaN.
Validation of KCa3.1 Channel Nifedipine Interaction Site Predicted by Rosetta Modeling Method

Calcium-activated potassium channels, including the intermediate-conductance KCa3.1 channel and the related small-conductance KCa2 channels, monitor and regulate intracellular calcium and are ideal pharmacological targets for immunosuppression, fibroproliferative disorders, hypertension and various neurological diseases. However, the development of drugs specifically for these medically relevant channels faces serious challenges because there is no available crystal structure that could be used for structure-assisted drug design. We used the Kv1.2-Kv2.1 channel structure (pdb id: 2R9R) as a template to generate a homology model of the KCa3.1 channel transmembrane region using the Rosetta modeling method. Docking of small molecules that are known to block KCa3.1 channel currents using Rosetta generated structural models of channel - drug complexes that can be validated using experimental approaches. Here we report the validation of the binding sites for the dihydropyridine nifedipine predicted by Rosetta's lowest energy stimulation of the KCa3.1 channel complex. We used a combination of site-directed mutagenesis and electrophysiological patch-clamp recording to test the identified amino acid residues located between the pore lining S5 and S6 segment. Blocking of the KCa3.1 channel by nifedipine was reduced by altering the side chains at positions L209, T212 and V278 to either alanine or valine, with T212 the most affected residue. Bulkier side-chain change to phenylalanine confirmed T212 as the main interacting site for nifedipine without compromising the channel's affinity for TRAM-34. Thus, by correctly identified the interaction of the dihydropyridine nifedipine with the KCa3.1 channel complex, Rosetta models can be used to understand the molecular mechanism of action of KCa channel blockers and gating modulators and assist with drug design efforts.
CMB dipoles and other low-order multipoles in the quasispherical Szekeres model

Several authors have previously shown that a Gpc-scale void based on the spherically symmetric Lema\^{\i}tre-Tolman-Bondi (LTB) model can provide a good fit to certain cosmological data, including the SNIa data, but it is only consistent with the observed CMB dipole if we are located very close to the center, in violation of the Copernican principle. In this work we investigate the more general quasispherical Szekeres model, which does not include spherical symmetry, in order to determine whether this option may be less constricting. We find that the observer is still constrained to a small region, but it is not as geometrically ``special'' as the center of a LTB void. Furthermore, whereas the quadrupole and octupole near the center of a LTB void are necessarily small, certain Szekeres models can include a significant quadrupole while still being consistent with the observed dipole, hinting that Szekeres models may be able to give an explanation for the observed quadrupole/octupole anomalies.
Analysis of Phycobilisome and Photosystem I Complexes of Cyanobacteria

Phycobilisomes (PBS) are supramolecular, multiprotein complexes which function as the light-harvesting antennae for Photosystem II (PS II) in the cyanobacteria, the chloroplasts of red algae, and the cyanelles of phylogenetically ambiguous flagellates such asCyanophora paradoxa (1). PBS occur as highly ordered arrays on the stromal surfaces of the thylakoids; each is believed to interact with two or more PS II reaction centers. PBS are predominantly composed of phycobiliproteins, a family of water-soluble proteins that carry linear tetrapyrrole chromophores (phycobilins; see 2). Each phycobiliprotein consists of two dissimilar subunits, denoted α and β, each of which carries 1–4 chromophores. The fundamental structural unit of the phycobiliproteins is the (αβ)3 trimer, a torroidal molecule about 11 nm indiameter and 3–3.5 nm in thickness with a central cavity about 3.5 nm in diameter (3, 4). Face-to-face stacking of two trimers produces (αβ)6 hexamers which are 11 × 6 nm. The assembly of larger substructures and PBS themselves requires the participation of a second class of proteins, the so-called “linker polypeptides,” which are absolutely required for the assembly of higher order structures (see below; also see 1, 2). The linker polypeptides probably fill the central cavity of the phycobiliprotein torroids and participate in the tail-to-tail joining of pairs of hexamers.
Zen Formulation of the Social Good

Ethicists often address the question of the social ‘good’ in terms of justice. Zen Buddhists, however, have never set forth a systematic formulation of justice. Perhaps this is not surprising, given that the concept originated in the West and hence is foreign to the tradition. To some Zen Buddhists the idea of ‘justice’ is not simply foreign but also contrary to the spirit of Zen. Treating justice in terms of judgment and punishment, Abe Masao writes: … the notion of justice is a double-edged sword. On the one hand, it sharply judges which is right and which is wrong. On the other hand, the judgment based on justice will naturally cause a counter-judgment as a reaction from the side thus judged. Accordingly, we may fall into endless conflict and struggle between the judge and the judged.1 In place of justice in this sense, Abe advocates prajnā as a recognition of everyone and everything in its nonsubstantial distinctiveness or ‘suchness’. From his perspective, justice and wisdom lead to very different ethical stances in society. To Abe, justice, ‘when carried to its final conclusion, often results in punishment, conflict, revenge and even war, whereas wisdom entails rapprochement, conciliation, harmony and peace’.2
Mesoscale modulation of air-sea CO2 flux in Drake Passage

We investigate the role of mesoscale eddies in modulating air-sea CO2 flux and associated biogeochemical fields in Drake Passage using in situ observations and an eddy-resolving numerical model. Both observations and model show a negative correlation between temperature and partial pressure of CO2 (pCO2) anomalies at the sea surface in austral summer, indicating that warm/cold anticyclonic/cyclonic eddies take up more/less CO2. In austral winter, in contrast, relationships are reversed: warm/cold anticyclonic/cyclonic eddies are characterized by a positive/negative pCO2 anomaly and more/less CO2 outgassing. It is argued that DIC-driven effects on pCO2 are greater than temperature effects in austral summer, leading to a negative correlation. In austral winter, however, the reverse is true. An eddy-centric analysis of the model solution reveals that nitrate and iron respond differently to the same vertical mixing: vertical mixing has a greater impact on iron because its normalized vertical gradient at the base of the surface mixed layer is an order of magnitude greater than that of nitrate. This article is protected by copyright. All rights reserved.
Abstract 994: Cardioprotection Against Myocardial Infarction by Ischemic Pre- and Post-Conditioning are Both Completely Abrogated by Acute Hyperglycemia

Introduction: Acute hyperglycemia (HG) is associated with larger infarct size, impaired cardiac function and increased mortality, independent of diabetes. We hypothesized that the cardioprotective effects of both ischemic pre- and post-conditioning (pre-C & post-C) would be impacted by acute HG. Methods: A total of 37 C57BL/6 mice were assigned to 6 groups. All mice underwent 40 min of LAD occlusion followed by 60 min of reperfusion. Acute HG (~400 mg/dl) was induced in 3 groups with an IP injection of dextrose (2g/kg body weight) given 40 min prior to the start of index ischemia. The ischemic pre-C protocol (2 groups) was 2 cycles of 5 min ischemia and 5 min reperfusion prior to index ischemia. The post-C protocol (2 groups) was 3 cycles of 5 sec reperfusion and 5 sec ischemia following index ischemia. Results: Risk region (RR, % of LV) as determined by Phthalo blue staining was similar among study groups (Fig, p = NS). In euglycemic control mice, infarct size (by TTC staining) without cardioprotection was 51.6 ± 2.0 % of RR (Fig). Early pre-C reduced infarct size to 25.5 ± 3.7 (a 50% reduction, p Conclusion: Acute hyperglycemia in non-diabetic mice completely abolishes the cardioprotective effects of both ischemic pre-C and post-C against myocardial infarction.
Corpus Luteum Rescue in Nonhuman Primates and Women

The primate corpus luteum undergoes a process at the end of a nonfertile menstrual cycle termed luteolysis, which involves considerable structural and functional changes that lead to a loss in the ability to produce the steroid hormone progesterone. Because progesterone is critical for events involved in embryo implantation and sustaining pregnancy, the survival and continued function of the corpus luteum are required throughout the first weeks of pregnancy, after which the placenta becomes responsible for the maintenance of gestation. Extension of the functional lifespan of the primate corpus luteum is achieved through the secretion of chorionic gonadotropin (CG) from the conceptus. CG signals through the luteinizing hormone–chorionic gonadotropin receptor (LHCGR) located on luteal cells to override the cellular and molecular events that are responsible for the demise of the corpus luteum during nonfertile cycles. Thus, in this chapter, the source of various CG forms and the regulation of their production, as well as the mechanisms through which LHCGR signaling regulates cellular activities in the primate corpus luteum during early pregnancy are reviewed. Also, current and possible uses of hCG forms for diagnosis and treatment of infertility and pregnancy disorders are considered.
The Consonantal Alternations in the Slavic Declensions

(1960). The Consonantal Alternations in the Slavic Declensions. WORD: Vol. 16, No. 2, pp. 183-203.
Efficacy of personalized models in discriminating high cognitive demand conditions using text-based interactions

Although high cognitive demand conditions can impair psychological, physical, and behavioral processes without appropriate management, current measurement methods are too cumbersome for continuous monitoring of cognitive demand, and do not account for individual differences. This research uses keystroke and linguistic markers of typed text to construct individualized models of cognitive demand response to discriminate high and low cognitive demand conditions, the results of which can have implications for design of cognitive demand monitoring systems for personalized health management. We constructed within-subject models of cognitive demand response for nine participants and one between-subjects model based on 20 participants. The AUCs for personalized models ranged from 0.679 to 0.953 (Mean=0.826, SD=0.085), significantly higher than chance (p<0.0001) and the 0.714 AUC for the generic model (p=0.002). Although the features in each model were different, the most common features across models are rate of negative emotion, lexical diversity, rate of words over six letters, and word count. These results confirm significant individual differences in cognitive demand response and suggest that those developing measurement methods used in a monitoring system should consider adaptation to individual characteristics. Our research operationalizes the effects of cognitive demand on HCI and contributes a unique combination of text and keystroke features used to detect high cognitive demand situations. An unobtrusive approach is proposed for classifying high cognitive demand conditions using typing and language features.Individualized models of high cognitive demand response are significantly more accurate than a generic model.Individualized models show significant interpersonal differences in the response to high cognitive demand.
Widom Lines in Binary Mixtures of Supercritical Fluids

Recent experiments on pure fluids have identified distinct liquid-like and gas-like regimes even under supercritical conditions. The supercritical liquid-gas transition is marked by maxima in response functions that define a line emanating from the critical point, referred to as Widom line. However, the structure of analogous state transitions in mixtures of supercritical fluids has not been determined, and it is not clear whether a Widom line can be identified for binary mixtures. Here, we present first evidence for the existence of multiple Widom lines in binary mixtures from molecular dynamics simulations. By considering mixtures of noble gases, we show that, depending on the phase behavior, mixtures transition from a liquid-like to a gas-like regime via distinctly different pathways, leading to phase relationships of surprising complexity and variety. Specifically, we show that miscible binary mixtures have behavior analogous to a pure fluid and the supercritical state space is characterized by a single liquid-gas transition. In contrast, immiscible binary mixture undergo a phase separation in which the clusters transition separately at different temperatures, resulting in multiple distinct Widom lines. The presence of this unique transition behavior emphasizes the complexity of the supercritical state to be expected in high-order mixtures of practical relevance.
Distinct Trajectories of Fatigue and Sleep Disturbance in Women Receiving Chemotherapy for Breast Cancer.

Purpose/objectives To examine self-reported severity of fatigue and disturbed sleep experienced daily by women with breast cancer during multiple cycles of chemotherapy, exploring potential classes of women experiencing similar symptom trajectories. . Design In a secondary analysis, classes of women experiencing similar patterns of fatigue and disturbed sleep were identified. . Setting Oncology clinics in the United States. . Sample 166 women with breast cancer receiving chemotherapy. . Methods Severity scores were self-reported daily using an automated system. Classes of fatigue and disturbed sleep severity were identified using latent growth mixture modeling. . Main research variables Fatigue, disturbed sleep, age, stage of disease, education, employment, marital status, chemotherapy regimen, hours lying down, and missed work. . Findings Three fatigue classes were identified. Conclusions Patterns of symptom trajectories for fatigue and disturbed sleep were distinguished by baseline symptom severity. . Implications for nursing Identification of women at risk for fatigue and disturbed sleep may allow clinicians to intensify symptom management.
A Practical Method of Sterility Monitoring of IV Admixtures and a Method of Implementing a Routine Sterility Monitoring Program

A practical procedure for sterility testing of intravenous admixtures contained in plastic bags using membrane filtration was developed. This technique was then evaluated in a pilot study involving...
Peptide and Recombinant Allergen Vaccines for Food Allergy

Food allergy is a significant public health problem, with no suitable treatments available for patients. Currently, patients are limited to avoidance and the use of readily available emergency medications. Immunotherapy is an appealing therapeutic strategy for inducing tolerance. Studies with whole native allergens have demonstrated the efficacy of immunotherapy for food allergy; however, the risk of IgE-mediated reactions with such treatment is significant. Advances in molecular biology techniques, including purification, sequencing, and cloning, have allowed researchers to identify specific allergen components and T cell binding epitopes. Support for the use of recombinant and peptide vaccines for food allergy comes from prior studies involving aeroallergens and hymenoptera venom. By manipulating allergen structure and IgE binding, allergenicity can be reduced, thereby reducing systemic reactions, making recombinant and peptide vaccines a safe and effective form of immunotherapy. Pre-clinical studies using in vitro and murine models demonstrated a more tolerant state following the use of these therapies. Studies with human subjects will be necessary to characterize the effects of recombinant and peptide food allergy vaccines and to demonstrate a safe treatment option for patients.
Recording to Measure Effectiveness

It is recommended that practitioners test an approach that emphasizes brevity in presentation, concreteness in planning, and evidence of treatment
Repair of Eyelid Defects with the Orbicularis Oculi Mobilization Technique: Naugle-Levine Procedure

Full-thickness large (>50%) defects of the upper and lower eyelids are challenging to reconstruct. The blood supply from advanced orbicularis oculi muscle flap allows for the utilization of both a skin graft and a posterior lamellar graft when desirable. The repair of eyelid defects incorporating orbicularis mobilization is particularly useful in patients who are monocular and in those patients who wish to avoid occlusion of the visual axis created by an eyelid sharing procedure. Herein, we describe the technique.
Ruthenate and cuprate high-Tc superconductivity

The onset of superconductivity is ≈49 K in Cu-doped (but cuprate-plane-free) Sr2YRuO6, almost the same as the ≈45 K onsets in GdSr2Cu2RuO8 and in R2 − z Ce z Sr2Cu2RuO10 (for R = Gd or Eu), implying that the superconductivity in all four compounds originates in the SrO layers, not in the cuprate-planes. Muon studies show that the superconducting condensate in YBa2Cu3O7 is either s-wave or extended s-wave, not d-wave, confirming earlier work.
Some Minimax Theorems and Applications to Nonlinear Partial Differential Equations

Publisher Summary This chapter reviews some existence theorems for critical points of a real-valued function on a real Banach space and to apply these results to elliptic and hyperbolic partial differential equations. The abstract results on critical points are obtained using minimax arguments. Applications to elliptic equations are thereafter provided for the same. A new proof is given for a recent result of Ahmad et al ., as well as some variants of their result. The work on abstract results on critical points is applied to hyperbolic problems.
Multielement analysis of housewares and other food-related items by a 241Am radioisotope X-ray fluorescence transportable spectrometer and handheld analyzers.

Radioisotopic X-ray fluorescence spectrometry (RXRFS) performed with an analyzer based on a 241 Am excitation source was investigated as a potential field method for screening housewares for the presence of toxic elements. A compact system based on commercially available detection and multichannel analyzer components was used to measure surface concentrations of Au, Ba, Bi, Cd, Ce, Co, Cs, Cu, Fe, La, Pb, Sb, Sn, Sr, Zn, and Zr in a wide variety of housewares and other food-related items. Certified reference material solders, glasses, and paint films and well-characterized oven-fired test tile glazes, solders, and metal can seams were analyzed to determine element sensitivities and analytical limits and to demonstrate the accuracy of the instrument. With analysis times of 3-5 min, the analyzer demonstrated 3σ limits of detection of ≤100 μg/cm 2 for elements with Z = 40-65 and Z > 70. Very good accuracy was demonstrated for glaze and thin-sample analyses, whereas analysis was possible for solders and metal can seams with greater uncertainties (20-40%). Two commercially available handheld RXRFS analyzers, evaluated as part of the study, yielded results that agreed well with those obtained with the 241 Am-based RXRFS system.
Sex Offending Behavior

Sex offending behavior in persons with intellectual disabilities (ID) is a serious problem with significant consequences for the victims, offenders, and their social communities (Barron, Hassiots, & Banes, 2002; Nezu, Nezu, & Dudek, 1998). A growing awareness of such problems in people with ID, as well as heightened societal and cultural sensitivity to the occurrence of sex offenses, requires effective solutions with regard to assessment and treatment.
Could Social Bots Pose a Threat to Public Health

The article focuses on the potential threat social bots, or automatic social media accounts utilizing artificial intelligence to promote specific products or ideas on social media, pose to public health. It comments on the relative lack of studies on social bots and mentions articles on the promotion of electronic cigarettes by social bots. It mentions proposed legislation in California that would require social bots to be easily identified and linked to a specific human user.
Will I Stay Married? Exploring Predictors of Expectations to Divorce in Unmarried Young Adults.

Expectations that one may eventually divorce may predict behavior in young adulthood and beyond, but studies that have looked at individuals’ assessments of their divorce likelihood have been limit...
On relationship between curve numbers and phi indices

Abstract The curve number and phi (φ)-index models each provide a simple one-parameter relationship between storm-event rainfall and runoff. It is shown that the curve number and φ-index models can both be used to segregate the rainfall hyetograph into initial abstraction, retention, and runoff amounts. However, the principal advantages of the φ-index model are that both rainfall distribution and duration can be explicitly taken into account in calculating runoff, and the φ index is more physically based than the curve number. The quantitative relationship between the curve number and the φ index is presented and validated with field measurements. Knowing the relationship between the curve number and the φ index is useful in that it facilitates using the extensive database of curve numbers in the more realistic φ-index model in calculating a runoff hydrograph from a given rainfall hyetograph. It is demonstrated that conventional adjustments to curve numbers can be largely explained by variations in storm duration, which suggests that variable rainfall duration can possibly be an essential factor in accounting for deviations from the median curve number of a catchment.
The relationship between pharmacy students' beliefs about medications and their academic achievement in a pharmacy practice counseling course.

Abstract Introduction Pharmacists’ beliefs about medications have been identified as a potential factor in how patients are counseled. However, no studies have assessed this relationship. Methods Third year pharmacy students were surveyed using previously validated questionnaires about medication beliefs, including the BMQ-General (General-Overuse and General-Harm subscales), Benefit, and Perceived Sensitivity to Medications (Sensitive Soma) scales; each is rated on a five-point Likert scale (higher scores represent stronger feelings). Belief profiles were created using two-step cluster analysis. Students also reported demographics and prior work in a pharmacy. Grades from simulated counseling sessions were collected via school records. Student t-test and multivariate linear regression were used to compare beliefs with grades. Results Among the 66 responders (84.5% response rate), 54.5% were female, 80.3% white, and 77.3% non-Hispanic; 84.8% reported prior work in a pharmacy. Overall mean (SD) belief scores were General-Overuse 3.12 (0.76), General-Harm 1.83 (0.53), Benefit 3.99 (0.55), and Sensitive Soma 2.37 (0.82). Cluster analyses revealed two beliefs profiles: negative profile (more feelings of overuse, harm, and sensitivity to medications) and positive profile (less feelings of overuse, harm, and sensitivity to medications). Students with positive belief profiles were graded higher by faculty compared to students with negative belief profiles (90.0 vs. 87.2, p = 0.014). Findings remained in a multivariate regression controlling for gender and prior work in a pharmacy. Conclusions Findings from this study demonstrate the need for greater understanding about the relationship between pharmacists’ beliefs about medications and patient counseling.
Using CFD simulations to develop an upward airflow displacement ventilation system for manure-belt layer houses to improve the indoor environment

Heat stress and disease outbreak result in significant losses in large-scale egg productions. New ventilation systems are needed for large-scale layer production facilities to provide safe and uniform indoor environment, especially in the changing climate of global warming. This study developed a new ventilation system, upward airflow displacement ventilation (UADV) system, which allows fresh air to enter a layer house through air ducts located at the bottom of the cages, move upward by thermal buoyancy caused by hens and static pressure differences caused by exhaust fans, and ultimately exit the house through the fans installed on the roof. The performance of the UADV system was evaluated in comparison with a typical tunnel ventilation (TV) system in terms of air-exchange effectiveness, thermal environment, and airborne pathogen dispersal in both summer and winter using a validated Computational Fluid Dynamics (CFD) model. The results showed that the UADV system resulted in 46%–129% greater air-exchange effectiveness within the cages and provided a more homogeneous thermal environment with 9.4% less heat stress in summer and 68% less cold stress in winter compared with the TV system. In addition, transport of pathogens was largely inhibited in the UADV system compared with the TV system due to upward airflow and minimum air mixing across the cages. When coupled with sensible cooling of supply air, UADV system can further improve the thermal environment with a much lower ventilation rate under extremely hot and humid weather conditions. However, higher ventilation rates were more effective for reducing potential pathogen dispersal.
Diplomats, Settlers and Travellers

Covering 1820–1830, the chapter focuses on trade and ties between the British government led by George Canning and Bernardino Rivadavia, the leading figure in Buenos Aires. Commercial contact and migration grew rapidly leading to the treaty of 1825 providing British settlers with special rights and protection. Soon after, war between Buenos Aires and Brazil led to the blockade of Buenos Aires that destroyed trade and good relations. The chapter relates early efforts to set up a British protectorate in the Rio de la Plata, and the experiences of British travellers attempting to develop mines in the Andes. It draws on numerous eye-witness accounts of British attempts to form agrarian colonies and of the economic and political collapse of the late 1820s.
Metasearch accuracy for letters and symbols: do our intuitions match empirical reality?

The “familiarity effect” (Shen and Reingold, Perception & Psychophysics 63(3):464–475, 2001) is a phenomenon in which unfamiliar symbols perceptually “pop-out” when placed among familiar symbols (e.g., letters). In contrast, searching for familiar symbols among unfamiliar symbols is more challenging. Failure to account for effects such as these when predicting search performance could lead to overconfidence and error. This study investigated metacognitive awareness of the familiarity effect by asking participants to rate the speed and accuracy of search before they searched for either letter or symbol targets among letter or symbol distractors. Feature overlap between target and distractor and target presence or absence were also manipulated to provide concurrent cues to task difficulty. This study examined metacognitive awareness of the “familiarity effect,” and extended the findings from an earlier metasearch study (Redford et al., Memory and Cognition 39:1534–1545, 2011). Metacognition was accurate with respect to the familiarity effect. However, participants incorrectly predicted that they would detect a target’s absence faster than its presence. These findings suggest that people have metacognitive awareness for some aspects of visual search, even when patterns of search performance are complex and potentially counterintuitive. However, limitations exist in our metacognitive awareness of visual search. The results are discussed in relation to Koriat’s cue utilization framework and heuristic-based metacognition.
Simple non-galvanic flip-chip integration method for hybrid quantum systems

A challenge faced by experimenters exploring hybrid quantum systems is how to integrate and interconnect different materials and different substrates in a quantum-coherent fashion. Here, we present a simple and inexpensive flip-chip bonding process, suitable for integrating hybrid quantum devices on chips from different substrates. The process only requires equipment and materials used routinely for contact photolithography, and it is possible to undo the bonding and reuse the chips. The technique requires minimal compressive force, so it is compatible with a wide range of different substrates. Unlike indium-based bonding, this process does not establish a galvanic connection between the two chips, but as we show, in some situations this is not necessary. We demonstrate the technique using lithographically patterned quarter-wave coplanar waveguide resonators, fabricated on one chip, and couple these inductively to a transmission line patterned lithographically on a separate chip. The two chips have a vertical interchip gap of about 7 μm, and we can repeatedly achieve lateral alignments of better than 2 μm. We measure electromagnetic resonances with low-power (∼1 photon) internal quality factors Qi around 5 × 105, comparable to single-chip performances, with as-designed coupling quality factors Qc ranging from 2 × 102 to 5 × 105.
Range Image Segmentation

The output of a range image sensor is the scene surface geometry in sampled form. It is most commonly represented as an image that is, a two-dimensional array of pixels, each pixel conveying the range of a sampled point on the surface from a reference point. This representation, though voluminous, conveys very little geometric or semantic information about the visible surfaces in the scene. The role of segmentation is to extract geometric primitives relevant to higher level cognitive processes from the pixel-level representation of a range image. The segmentation process partitions a range image into geometric primitives so that all the image pixels are grouped into clusters with a common geometric representation or property.
An Autonomous Loop-Closure Approach for Simultaneous Exploration and Coverage of Unknown Infrastructure Using MAVs

The recent proliferation of low-cost Micro Aerial Vehicles (MAV) offers an attractive means for inspecting critical infrastructure autonomously. However, to enable such autonomous tasks requires a precise spatial model of the structure and operational area, typically constructed using sensor measurements obtained from the environment. To facilitate autonomous inspection capabilities, we address the problem of autonomous MAV exploration and coverage of an unknown structure to acquire the spatial information necessary for the development of a high-fidelity 3D model of the structure. Key to this problem is to not only cover the entire structure to acquire a complete set of spatial measurements, but also to minimize accumulative data errors during the exploration through direct planning of loop closures. We introduce a real-time waypoint planning approach to guide MAV motions to achieve complete exploration, coverage, and loop closure while respecting limited onboard resources.
How to Overcome the Valley of Death from Basic Science to Clinical Trials

In a laboratory setting, regenerative medicine has proven its potential to revolutionize modern medicine. The translational science model is designed to drive scientific discoveries out of the laboratory and into routine clinical practice from ‘the bench to the bedside.’ However, the reality of this process is that most innovations fail to achieve their desired clinical impact. Each step of translational process faces a unique set of barriers that require a significant amount of time, effort, and money to overcome. Despite these challenges, successful innovations have the potential to impact the lives of patients worldwide. With the appropriate knowledge and planning, the translational scientist can successfully bridge the gap between the basic scientist and the clinician, converting scientific breakthroughs into novel treatments and therapies for patients.
Impact of the Oncology Care Model (OCM) on pain management: A retrospective cohort analysis.

86Background: Pain is a common symptom among patients with cancer and impacts performance status and quality of life. The OCM was implemented at Rutgers Cancer Institute of New Jersey (RCINJ) in Ju...
Predictors of parenting attitudes in an at-risk sample: Results from the LONGSCAN study.

Abstract Background Associations between parenting attitudes and behavior and children’s adjustment are well-established, including links between negative parenting beliefs and increased risk for child maltreatment and poorer child functioning. Considerably less is known regarding what factors may correspond with parenting attitudes, particularly among at-risk samples. In line with theoretical models of the determinants of parenting, the aim of the study was to investigate correlates of parenting attitudes among child, caregiver, family, and neighborhood factors. Participants and settings/methods The study included 1071 4-year-old children (48.8 % female; 55.7 % Black) and their caregivers from the Longitudinal Studies in Child Abuse and Neglect (LONGSCAN) study. Results Numerous factors were consistently related to more positive parenting attitudes (i.e., more appropriate parenting expectations, greater empathy, and valuing non-physical punishment), including greater educational attainment, caregiver history of child sexual and physical abuse, lower levels of children’s internalizing symptoms, greater family income, and lower levels of psychological aggression. Lower levels of caregiver depressive symptoms, greater number of maltreatment allegations, use of nonviolent discipline, and less severity of stressful life events were tied to more adaptive parenting attitudes in one or two domains. Conclusions Caregiver, child, familial, and environmental factors, as well as child maltreatment, may be important in determining parenting attitudes. Identification of the drivers of parenting attitudes may aid identification and intervention efforts with high-risk samples of caregivers to help improve parenting outcomes.
Management of Cutibacterium acnes and total shoulder arthroplasty: has consensus been achieved?

Abstract Background Periprosthetic shoulder infection remains a difficult complication to identify and treat. In efforts to improve provide clarity, a subgroup of the Second International Consensus Meeting on Musculoskeletal Infection (ICM) generated over 70 recommendations. To understand the current treatment practices and impact of the ICM's work, a survey of shoulder arthroplasty providers was performed. Methods A 22-question survey, consisting of questions based upon the ICM consensus statement and the clinical experience of these authors, was distributed to all active members of the American Shoulder and Elbow Surgeons. Questions regarded the work-up, diagnosis, and treatment of periprosthetic shoulder infection—with specific attention to Cutibacterium acnes. Results One hundred fifty-nine members completed the survey (16%; 159/990) between August 8 and October 18, 2019. Only two-thirds of respondents reported utilizing the definition of periprosthetic shoulder infection proposed by the ICM subgroup. The survey results and associated literature review provided here demonstrate continued discordance regarding the diagnostic work-up and treatment of periprosthetic shoulder infection. Conclusion It is imperative that the shoulder arthroplasty community adopts a uniform definition for periprosthetic shoulder infection as well as a multispecialty team-based approach to improve patient care and better focus future research. Level of Evidence Level IV; Survey Study; Case Series
Notes on species of some genera of Rosaceae, China

In the course of preparing an account of some genera in the Rosaceae for the Flora of China, some species have been taxonomically revised based on herbarium materials(particularly type specimens), and on the literature concerned. Some new combinations have been made and two varieties have been described as new.
Metabolism of the Selective Matrix Metalloproteinase-9 Inhibitor (R)-ND-336.

(R)-ND-336—designated as compound (R)-5—is a highly selective inhibitor of matrix metalloproteinase (MMP)-9 with efficacy in accelerating diabetic wound healing in murine models. (R)-ND-336 belongs...
Urban food sharing: Rules, tools and networks, by Anna R. Davies: Bristol, England, Policy Press, 2019

Likely for all of human civilization, the act of sharing food with others has been instrumental in the development of complex social relationships and customs, not to mention the basic survival of ...
Pediatric Epilepsy Surgery in Focal and Generalized Epilepsy: Current Trends and Recent Advancements

For a subset of children with medically intractable epilepsy, surgery may provide the best chances of seizure freedom. Whereas the indications for epilepsy surgery are commonly thought to be limited to patients with focal epileptogenic foci, modern imaging and surgical interventions frequently permit successful surgical treatment of generalized epilepsy. Resection continues to be the only potentially curative intervention; however, the advent of various neuromodulation interventions provides an effective palliative strategy for generalized or persistent seizures. Although the risks and benefits vary greatly by type and extent of intervention, the seizure outcomes appear to be uniformly favorable. Advances in both resective and nonresective surgical interventions provide promise for improved seizure freedom, function, and quality of life. This review summarizes the current trends and recent advancements in pediatric epilepsy surgery from diagnostic workup and indications through surgical interventions and postoperative outcomes.
How Stephen Mather Sold the Park Service Idea

(1971). How Stephen Mather Sold the Park Service Idea. Environmental Education: Vol. 2, No. 4, pp. 21-24.
Sensory Neuromodulators in Disorders with Delayed Gastric Emptying

There is considerable overlap in clinical presentation between functional dyspeptic and vomiting syndromes associated with inherent delay in gastric emptying and neuromuscular dysfunction of gastric emptying mechanisms resulting in true gastroparesis. Symptomatic foregut disorders with delayed gastric emptying may respond to treatment with sensory neuromodulators. Tricyclic antidepressants are the agents used most often, and as many as three quarters of patients may demonstrate moderate symptom improvement. Systematic, large clinical trials using these agents do not exist, however, and much of the experience has been extracted from the use of sensory neuromodulators in overlapping functional syndromes. In this chapter, the role of sensory modulators in managing foregut symptoms is discussed, side effects are characterized, and guidelines for use are detailed.
Health-related Services in Multilateral and Preferential Trade Arrangements in Asia and the Pacific

In many developing countries, the health-care sector is under-developed, lacking basic infrastructure and human capital, and attracting little attention from investors and policymakers. While encouraging globalization and trade may aggravate those problems and create additional costs in some circumstances, trade liberalization and deeper integration into the global economy could also provide opportunities and resources to address those problems more effectively. This paper contributes to the debate by reporting on the status of liberalization achieved in the health services sector by members of ESCAP through their regional and multilateral trade liberalization commitments.
A Quantitative Methodological for Evaluating Approval Plan Performance

An analytic methodology for examining approval returns is developed to determine if exclusion by subject code is desirable. Publisher exclusion is discussed. The correspondence between vendor-assigned codes and Library of Congress call numbers is evaluated and the concept of "fair share" of books allotted to various departments is looked at. Vendor generated sales/returns reports may not provide adequate detail for analysis of acquisitions patterns. Support is lent to the suggestion made in earlier studies that approval plans do not work well for sci/tech areas.
The design of beam pickup and kickers

The behavior of beam pickup and kickers subjected to the electromagnetic fields of relativistic charged particles is examined. The concept of image currents is explained. The frequency domain response of a simple stripline pickup is derived and the behavior of kickers is explained through Lorentz reciprocity.
A Biomechanical Analysis of the Contributing Factors to Increases in Vertical Jump Height Following Exercise with Weighted Vests

Background and objectives: It has been shown that a bout of jumping exercise with weighted vests increases the subsequent countermovement jump height. However, it is not clear whether the improvement in jump height is due to the enhancement of joint power or due to other mechanisms such as neural adaptations. Methods: To investigate this dichotomy, we tested the acute neuromechanical changes following a preloaded exercise protocol (3 sets of 5 consecutive CMJs with a weighed vest equal to 15% of the body mass of the participant) that successfully increased the subsequent jump height. On average, jump height increased 1.52 cm (5.4%) after this exercise as compared to CMJs prior to the exercise protocol. Results: A significant decrease in the time from the start of the movement to take off (pre-take off duration) was observed. This decrease was exclusively caused by exercising with a weighted vest, since such a change was not observed in the control sessions in which participants exercised without the weighted vest. Our data showed that jumpers leave the ground with some degrees of knee flexion and upon exercising with weighted vest this amount of flexion increased and hence an increase in the jump height. However, no significant changes in peak values of lower limb joint angle, velocity, moment and power were observed. Conclusion: It is suggested that for designing weighted vest exercise protocols with the aim of increasing jump height, the idea of modifying the timing of the movement should be considered as a cause of the enhancement. This novel idea adds another mechanism for increasing the jump height following weighted vest exercise, along with the general belief of muscle potentiation. .
Insertion of the human immunodeficiency virus CD4 receptor into the envelope of vesicular stomatitis virus particles.

Abstract Enveloped virus particles carrying the human immunodeficiency virus (HIV) CD4 receptor may potentially be employed in a targeted antiviral approach. The mechanisms for efficient insertion and the requirements for the functionality of foreign glycoproteins within viral envelopes, however, have not been elucidated. Conditions for efficient insertion of foreign glycoproteins into the vesicular stomatitis virus (VSV) envelope were first established by inserting the wild-type envelope glycoprotein (G) of VSV expressed by a vaccinia virus recombinant. To determine whether the transmembrane and cytoplasmic portions of the VSV G protein were required for insertion of the HIV receptor, a chimeric CD4/G glycoprotein gene was constructed and a vaccinia virus recombinant which expresses the fused CD4/G gene was isolated. The chimeric CD4/G protein was functional as shown in a syncytium-forming assay in HeLa cells as demonstrated by coexpression with a vaccinia virus recombinant expressing the HIV envelope protein. The CD4/G protein was efficiently inserted into the envelope of VSV, and the virus particles retained their infectivity even after specific immunoprecipitation experiments with monoclonal anti-CD4 antibodies. Expression of the normal CD4 protein also led to insertion of the receptor into the envelope of VSV particles. The efficiency of CD4 insertion was similar to that of CD4/G, with approximately 60 molecules of CD4/G or CD4 per virus particle compared with 1,200 molecules of VSV G protein. Considering that (i) the amount of VSV G protein in the cell extract was fivefold higher than for either CD4 or CD4/G and (ii) VSV G protein is inserted as a trimer (CD4 is a monomer), the insertion of VSV G protein was not significantly preferred over CD4 or CD4/G, if at all. We conclude that the efficiency of CD4 or CD4/G insertion appears dependent on the concentration of the glycoprotein rather than on specific selection of these glycoproteins during viral assembly.
Endoplasmic Reticulum-Associated Degradation (ERAD) of Misfolded Glycoproteins and Mutant P23H Rhodopsin in Photoreceptor Cells

Membrane proteins, such as rhodopsin, often undergo N-linked glycosylation after translocation into the endoplasmic reticulum (ER). N-linked glycans are markers for correct protein folding, protein quality control, transport, and recognition by the ER-associated degradation (ERAD) machinery. The ER contains many resident proteins that promote correct folding of newly synthesized proteins and prevent inappropriate aggregation of protein-folding intermediates. The quality control mechanisms of the ER guarantee that only correctly folded proteins exit the ER and progress through the secretory pathway. Here, we review the ERAD pathway for glycoproteins and discuss recent reports linking ERAD to the development of retinitis pigmentosa arising from misfolded rhodopsin.