cssi/SciSciGPT-SciSciNet huggingface dataset:
Pulmonary function in morbid obesity.

SUMMARY Morbid obesity is not infrequently associated with severe respiratory impairment. In our experience approximately 10 per cent of morbidly obese patients who underwent gastric surgery had severe respiratory impairment. Respiratory insufficiency of obesity can be divided into two primary breathing disorders: the obstructive sleep apnea syndrome (SAS) and the obesity hypoventilation syndrome (OHS). In its most severe form, when both SAS and OHS are present, it is called the Pickwickian syndrome. In our series 59 morbidly obese patients with respiratory insufficiency secondary to obesity underwent gastric surgery for weight reduction. Fourteen had OHS, 19 had SAS and 26 had both. Of these, two patients died of postoperative complications and one died at five weeks with an inconclusive autopsy, totalling an operative mortality rate of 3.4 per cent and a total mortality of 5.1 per cent. In our overall experience morbidly obese patients lost 67 per cent of excess weight after gastric procedures. In conclusion, surgically induced weight loss will markedly improve or correct respiratory insufficiency secondary to obesity. It will improve arterial oxygenation, minimize CO2 retention, expand lung volumes, correct polycythemia, and reduce apnea frequency. The magnitude of changes in these variables is clinically significant. Therefore, respiratory insufficiency of obesity should be considered a major indication for an aggressive approach to weight reduction. The jejunoileal bypass and unbanded gastroplasty operations have an unacceptable incidence of complications or failure, respectively. There is a high degree of recidivism following dietary programs. Sweets eaters will not do well with a gastroplasty procedure.31 Gastric bypass for individuals addicted to sweets or the vertical banded gastroplasty for “gorgers” are currently our procedures of choice and are associated with the average loss of two thirds of excess weight and correction of breathing problems associated with morbid obesity.
SEARCH-EFFECTIVENESS MEASURES FOR SYMBOLIC MUSIC QUERIES IN VERY LARGE DATABASES

In the interest of establishing robust benchmarks for search efficiency, we conducted a series of tests on symbolic databases of musical incipits and themes taken from several diverse kinds of repertories. The results we report differ from existing studies in four respects: (1) the data quantity is much larger (c. 100,000 entries in all); (2) the levels of melodic precision are more refined; (3) anchored and unanchored searches were differentiated; and (4) results from combination pitchand-rhythm searches were compared with those for pitch-only searches.
Conditional cooperation in network public goods experiments

Abstract This study investigates the pattern of contribution decisions in a network public goods game. In this game, each player’s payoff depends only on his own contribution and the contributions of his immediate neighbors in a circle network. As in the standard public goods game, we find substantial heterogeneity in behavior across subjects, including both unconditional free-riding and full cooperation, as well as conditional cooperation. We first examine the impact of different information conditions on conditional cooperation. At the aggregate level, we find that players who observe average payoff information about others contribute significantly less than those who observe average contribution information. We then investigate the extent to which conditional cooperators facilitate the spread of cooperation and free-riding behavior across the network. In groups with a single free-rider type, we show that individual contributions decay faster for players who are closer in the network to the free rider. On the other hand, in groups with a single unconditional full contributor type, players do not respond by converging to full cooperation. Instead, we find that proximity to the unconditional full contributor seems only to mitigate (or delay) the typical decline in contributions over time. These contrasting effects are consistent with the widespread claim that conditional cooperation is imperfect, or exhibits a self-serving bias.
DESENVOLVIMENTO DE SISTEMA PARA CÁLCULO DE ADUBAÇÃO ORGÂNICA DE HORTALIÇAS

Sistema web, responsavel pelo calculo de adubacao orgânica de hortalicas por meio da analise de solo, analise de composto e necessidade de cada cultura, visando quantificar e suprir suas necessidades nutricionais (N, P, K, Ca e Mg) e tambem aumentar a eficiencia e viabilidade do uso do calculo de aducao. Foi desenvolvido usando conhecimentos especificos referentes as principais culturas hortalicas, atendendo as demandas de nutrientes. As informacoes referentes ao cultivo e calculos foram baseadas na literatura, como artigos, livros e receituarios de instituicoes de credibilidade. Buscando uma ferramenta de simples manuseio para uso dos produtores, onde com o processo de execucao dos calculos preencherao uma base de dados onde serao salvos. O desenvolvimento do sistema teve como objetivo solucionar um problema de praticidade, por muitas vezes os produtores acabam nao tendo acesso as devidas informacoes, referentes a adubacao orgânica, ocasionando perdas na producao.
Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia

Acupuncture is an alternative treatment for wide spectrum chronic pain. However, its validity remains controversial due to the disputed efficacy assessed in various clinical studies. Moreover, variability amongst individuals complicates the predictability of outcome, which impedes the integration of acupuncture into mainstream pain management programs. In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine A1 receptor activation at the acupuncture point, we here report that in acute and chronic animal pain models, oral intake of caffeine, a potent adenosine receptor antagonist, interferes with acupuncture analgesia, even at a low dose. Local administration of caffeine at the acupuncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caffeine. Such interference was reversible, as caffeine withdrawal fully restored the efficacy of acupuncture by the next day, and long-term exposure to caffeine did not alter A1 receptor expression at the acupuncture point. Combined, these data indicate that a trace amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffeine consumption during acupuncture may improve pain management outcomes.
The pursuit of college for all: Ends and means in ‘no excuses’ charter schools:

In recent years, ‘No Excuses’ charter schools have been hailed as a promising solution to closing the ‘achievement gap’ between low-income students of color and their high-income White peers. These...
Abstract 666: CD37 tetraspanin as a novel biomarker for PD-1 blockade in diffuse large B-cell lymphoma

PD-1 immune checkpoint blockade reconstituting antitumor immunity has changed the cancer treatment paradigm. PD-1 blockade has been successful in many types of solid tumors and Hodgkin lymphoma, but not yet for diffuse large B cell lymphoma (DLBCL), the most common aggressive B-cell lymphoma. We found several biomarkers including loss of CD37 tetraspanin expression in DLBCL correlated with increased PD-1 expression suggesting potential sensitivity of these DLBCL subsets to PD-1 blockade. CD37 (TSPAN26) is a member of the tetraspanin superfamily, widely expressed on normal and malignant mature B-cells and downregulated in plasma cells. It has been documented that CD37 plays important roles in T-cell-B-cell interactions, B-cell humoral response triggered by B-cell receptor cross-linking, and a balance between immune responses and tolerance. Interestingly, in a large cohort of DLBCL patients, we found that loss of CD37 expression in DLBCL predicts strikingly decreased overall and progression-free survival rates, and that PDCD1 gene expression was upregulated in CD37-negative activated B-cell-like (ABC) DLBCL by gene expression profiling, whereas the costimulatory molecule ICOSLG was upregulated in CD37+ germinal center B-cell-like (GCB) DLBCL. Using the new fluorescent multiplex technology, we further measured PD-1 and PD-L1 expression at the protein level on lymphoma cells and immune cells in the tumor microenvironment, and found that PD-1 protein levels were increased on both cytotoxic and helper T-cells infiltrating in CD37-negative DLBCL either of GCB or ABC subtype. These novel discoveries suggest that CD37 is important for sustained antitumor adaptive immunity, that immune dysregulation plays an important role for poor clinical outcomes in DLBCL, and that CD37-negative DLBCL may be sensitive to PD-1 blockade. In summary, loss of a CD37 tetraspanin was found to correlate with PD-1 overexpression in DLBCL clinical samples, and CD37 may serve as a novel biomarker for anti-PD-1 immunotherapy clinical trials in DLBCL. Note: This abstract was not presented at the meeting. Citation Format: Zijun Y. Xu-Monette, Ken H. Young. CD37 tetraspanin as a novel biomarker for PD-1 blockade in diffuse large B-cell lymphoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 666. doi:10.1158/1538-7445.AM2017-666
FDA Benefit‐Risk Assessment of Osimertinib for the Treatment of Metastatic Non‐Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor T790M Mutation

On March 30, 2017, the U.S. Food and Drug Administration (FDA) approved osimertinib for the treatment of patients with metastatic, epidermal growth factor receptor (EGFR) T790M mutation-positive, non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, whose disease has progressed following EGFR tyrosine kinase inhibitor (TKI) therapy. Approval was based on demonstration of a statistically significant difference in the primary endpoint of progression-free survival (PFS) when comparing osimertinib with chemotherapy in an international, multicenter, open-label, randomized trial (AURA3). In this confirmatory trial, which enrolled 419 patients, the PFS hazard ratio for osimertinib compared with chemotherapy per investigator assessment was 0.30 (95% confidence interval 0.23-0.41), p 20%) in patients treated with osimertinib were diarrhea, rash, dry skin, nail toxicity, and fatigue. Herein, we review the benefit-risk assessment of osimertinib that led to regular approval, for patients with metastatic NSCLC harboring EGFR TKI whose disease has progressed on or after EGFR TKI therapy. Implications for practice Osimertinib administered to metastatic non-small cell lung cancer (NSCLC) patients harboring an EGFR T790M mutation, who have progressed on or following EGFR TKI therapy, demonstrated a substantial improvement over platinum-based doublet chemotherapy as well as durable intracranial responses. The ability to test for the T790M mutation in plasma using the FDA-approved cobas EGFR Mutation Test v2 (Roche, Basel, Switzerland) identifies patients with NSCLC tumors not amenable to biopsy. Since a 40% false-negative rate has been observed with the circulating tumor DNA test, re-evaluation of the feasibility of tissue biopsy is recommended to identify patients with a false-negative plasma test result who may benefit from osimertinib.
Is Andy Warhol Marianne Moore? Celebrity, Celibacy and Subversion

At first blush, Moore and Warhol associate to different realms in 1950s New York. But these two emigrants from the Pennsylvania interior (1918 and 1949, respectively), both active transformers of the art world and of gender and sex norms, resonate. This essay explores the anomalous similarity of their personal lives (both lifelong bachelors lived with their mothers for decades in New York and created their own iconic personae), and the linked evolution of their meaning-making in the postwar scene (both produced art that explores celebrity culture from within and critiques high/low hierarchies). Their joint appearance in the December 1954 issue of Vogue provides the point of departure into a reading of Moore’s poem “Rosemary.”
Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure

We compared sepsis "time zero" and Centers for Medicare and Medicaid Services (CMS) SEP-1 pass rates among 3 abstractors in 3 hospitals. Abstractors agreed on time zero in 29 of 80 (36%) cases. Perceived pass rates ranged from 9 of 80 cases (11%) to 19 of 80 cases (23%). Variability in time zero and perceived pass rates limits the utility of SEP-1 for measuring quality.
Methane ignition by frictional impact heating

Abstract As part of a program conducted by the Bureau of Mines to reduce the explosion hazard in coal mines, a study was made of the frictional ignition source that can develop to cause the ignition of methane when a coal mining machine encounters rock strata or hard inclusions. Such impacts between metal and rock reproduced by a laboratory machine caused a number of ignitions. A model is proposed that considers the mechanisms of energy dissipation during tangential impact. The total energy calculated from the model agrees well with the impact energy measured with the laboratory machine. Calculations show that during severe tangential impact in which a smear of molten metal is deposited on the rock, most of the impact energy is converted into heat at the interface while only about 1% of the energy goes into rock removal. The hot smear on the rock has the potential for igniting methane. The variables that affect the temperature, lifetime, and area of the hot smear are considered from the model. The cooling curve of a typical impact zone is calculated from the model and compares favorably with experimental findings. Calculations from the model show the hot area to increase linearly with impact speed; this agrees with the experimental results of the increasing ignition probability with increasing speed. The model is used to predict the effect of the heat of oxidation, heat of formation, dimensions of the tool, and dimensions of the rock on the ignition of methane.
Target Resolution Properties of the Multi-Tone Sinusoidal Frequency Modulatedwaveform

The mainlobe width of a waveform’s Ambiguity Function (AF) determines its ability to resolve multiple closely spaced targets in time-delay (range) and Doppler (range-rate). The contour of the AF’s mainlobe is well approximated by a coupled ellipse known as the Ellipse Of Ambiguity (EOA) whose parameters can be directly calculated in closed form if the waveform’s modulation function is known. The Multi-Tone Sinusoidal Frequency Modulated (MTSFM) waveform possesses a modulation function that is represented using a Fourier series expansion. These Fourier coefficients act as a set of tunable parameters that can be adjusted to synthesize waveforms with desired properties. This paper derives closed form expressions for the EOA parameters of the MTSFM and demonstrates their mainlobe characteristics via simulation.
Injection current in ferroelectric group-IV monochalcogenide monolayers

We study the injection current response tensor (also known as circular photogalvanic effect or ballistic current) in ferrolectric monolayer GeS, GeSe, SnS, and SnSe. We find that the injection current is perpendicular to the spontaneous in-plane polarization and could reach peak (bulk) values of the order of ${10}^{10}\phantom{\rule{4pt}{0ex}}\mathrm{A}\phantom{\rule{0.16em}{0ex}}{\mathrm{V}}^{\ensuremath{-}2}\phantom{\rule{0.16em}{0ex}}{\mathrm{s}}^{\ensuremath{-}1}$ in the visible spectrum. The magnitude of the injection current is the largest reported in the literature to date for a two dimensional material. To rationalize the large injection current, we correlate the injection current spectrum with the joint density of states, electric polarization, strain, etc. We find that various factors such as anisotropy, in-plane polarization and wave function delocalization are important in determining the injection current tensor in these materials. We also find that compression along the polar axis can increase the injection current (or change its sign), and hence strain can be an effective control knob for their nonlinear optical response. Conversely, the injection current can be a sensitive probe of the crystal structure.
Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome

Decreased corneal innervation is frequent in patients with Sjogren Syndrome (SS). To investigate the density and morphology of the intraepithelial corneal nerves (ICNs), corneal sensitivity, epithelial cell proliferation, and changes in mRNA expression of genes that are involved in autophagy and axon targeting and extension were assessed using the IL-2 receptor alpha chain (CD25 null) model of SS. ICN density and thickness in male and female wt and CD25 null corneas were assessed at 4, 6, 8, and 10/11 wk of age. Cell proliferation was assessed using ki67. Mechanical corneal sensitivity was measured. Quantitative PCR was performed to quantify expression of beclin 1, LC3, Lamp-1, Lamp-2, CXCL-1, BDNF, NTN1, DCC, Unc5b1, Efna4, Efna5, Rgma, and p21 in corneal epithelial mRNA. A significant reduction in corneal axon density and mechanical sensitivity were observed, which negatively correlate with epithelial cell proliferation. CD25 null mice have increased expression of genes regulating autophagy (beclin-1, LC3, LAMP-1, LAMP-2, CXCL1, and BDNF) and no change was observed in genes that were related to axonal targeting and extension. Decreased anatomic corneal innervation in the CD25 null SS model is accompanied by reduced corneal sensitivity, increased corneal epithelial cell proliferation, and increased expression of genes regulating phagocytosis and autophagy.
Conceptual modifications of coal preparation plants to minimize potential environmental issues associated with coal waste disposal

Abstract An environmental concern at coal preparation operations is the release of elements resulting from the oxidation or dissolution of certain minerals contained in the process waste streams. Using a standard conductivity test, the electrical conductivity (EC) of water samples obtained from mixing with various particle size and density fractions of a given plant waste material were measured as an indicator of total dissolved solids. The net neutralization potential (NNP) of the fractions were also measured to predict the pH of the supernatant upon disposal. As a result, the particle size and density fractions contributing to high EC levels were identified with the objective of potentially extracting and isolating these fractions which can significantly reduce the negative environmental impacts. The results showed that the EC generated from coarse refuse streams were significantly higher than the values obtained from fine refuse streams. Based on the NNP values, the coarse refuse stream generates highly acidic pH, while the fine refuse in contact with water produces circumneutral pH. Furthermore, the high specific gravity (>2.68) fractions which comprised less than 10% of the coal waste streams were found to be the primary source of elevated EC levels. The remaining fractions were found to be of minimal environmental concern. Based on the obtained results, modifications to the coal preparation plants were proposed to minimize the environmental concerns of coal waste disposal. Modifications include pyrite removal from the spiral refuse and desulfurization of flotation feed and sieve bend underflow streams using low-cost mineral spiral circuitry. After the segregation, the pyrite (high density) fraction, which encompasses around 1% of the coarse and fine refuse streams, will be isolated/encapsulated and the fine refuse stream dewatered and co-disposed with the coarse refuse stream. The proposed modifications to the processing and disposal practices not only minimize the generation of acid mine drainage thereby reducing the release of trace elements and EC of the discharged water, but also enhances the recovery and quality of the final clean coal product.
Fluorogenic Photoaffinity Labeling of Proteins in Living Cells

Genetically encoded fluorescent proteins or small-molecule probes that recognize specific protein binding partners can be used to label proteins to study their localization and function with fluorescence microscopy. However, these approaches are limited in signal-to-background resolution and the ability to temporally control labeling. Herein, we describe a covalent protein labeling technique using a fluorogenic malachite green probe functionalized with a photoreactive cross-linker. This enables a controlled covalent attachment to a genetically encodable fluorogen activating protein (FAP) with low background signal. We demonstrate covalent labeling of a protein in vitro as well as in live mammalian cells. This method is straightforward, displays high labeling specificity, and results in improved signal-to-background ratios in photoaffinity labeling of target proteins. Additionally, this probe provides temporal control over reactivity, enabling future applications in real-time monitoring of cellular events.
Many-body localization in spin chains with long-range transverse interactions: Scaling of critical disorder with system size

We investigate many-body localization in the chain of interacting spins with a transverse power-law interaction, ${J}_{0}/{r}^{\ensuremath{\alpha}}$, and random on-site potentials, ${\ensuremath{\phi}}_{i}\ensuremath{\in}\left(\ensuremath{-}W/2,W/2\right)$, in the long-range limit, $\ensuremath{\alpha}l3/2$, which has been recently examined experimentally on trapped ions. The many-body localization threshold is characterized by the critical disordering, ${W}_{c}$, which separates localized ($Wg{W}_{c}$) and chaotic ($Wl{W}_{c}$) phases. Using the analysis of the instability of localized states with respect to resonant interactions complemented by numerical finite-size scaling, we show that the critical disordering scales with the number of spins, $N$, as ${W}_{c}\ensuremath{\approx}[1.37{J}_{0}/(4/3\ensuremath{-}\ensuremath{\alpha})]{N}^{4/3\ensuremath{-}\ensuremath{\alpha}}lnN$ for $0l\ensuremath{\alpha}\ensuremath{\le}1$, and as ${W}_{c}\ensuremath{\approx}[{J}_{0}/(1\ensuremath{-}2\ensuremath{\alpha}/3)]{N}^{1\ensuremath{-}2\ensuremath{\alpha}/3}{ln}^{2/3}N$ for $1l\ensuremath{\alpha}l3/2$, while the transition width scales as ${\ensuremath{\sigma}}_{W}\ensuremath{\propto}{W}_{c}/N$. We use this result to predict the spin long-term evolution for a very large number of spins ($N=50$), inaccessible for exact diagonalization, and to suggest the rescaling of hopping interaction with the system size to attain the localization transition at finite disordering in the thermodynamic limit of infinite number of spins.
LearnX: A Hybrid Deterministic-Statistical Defect Diagnosis Methodology

Software-based diagnosis analyzes the observed response of a failing circuit to pinpoint potential defect locations and deduce their respective behaviors. It plays a crucial role in finding the root cause of failure, and subsequently facilitates yield analysis, learning and optimization. This paper describes a two-phase, physically-aware diagnosis methodology called LearnX to improve the quality of diagnosis, and in turn the quality of design, test and manufacturing. The first phase attempts to diagnose a defect that manifests as a well-established fault behavior (e.g., stuck or bridge fault models). The second phase uses machine learning to build a model (separate for each defect type) that learns the characteristics of defect candidates to distinguish correct candidates from incorrect ones. Results from 30,000 fault injection experiments indicate that LearnX returns an ideal diagnosis result (i.e., a single candidate correctly representing the injected fault) for 73.2% of faulty circuits, which is 86.6% higher than state-of-the-art commercial diagnosis. Silicon experiments further demonstrate the value of LearnX.
Online Learning for Markov Decision Processes in Nonstationary Environments: A Dynamic Regret Analysis

In an online Markov decision process (MDP) with time-varying reward functions, a decision maker has to take an action before knowing the current reward function at each time step. This problem has received many research interests because of its wide range of applications. The literature usually focuses on static regret analysis by comparing the total reward of the optimal offline stationary policy and that of the online policies. This paper studies a different measure, dynamic regret, which is the reward difference between the optimal offline (possibly nonstationary) policies and the online policies. The measure suits better the time-varying environment. To obtain a meaningful regret analysis, we introduce a notion of total variation for the time-varying reward functions and bound the dynamic regret using the total variation. We propose an online algorithm, Follow the Weighted Leader (FWL), and prove that its dynamic regret can be upper bounded by the total variation. We also prove a lower bound of dynamic regrets for any online algorithm. The lower bound matches the upper bound of FWL, demonstrating the optimality of the algorithm. Finally, we show via simulation that our algorithm FWL significantly outperforms the existing algorithms in literature.
Long-term impacts of the CARE program on teachers' self-reported social and emotional competence and well-being

Abstract Teacher stress is at an all-time high, negatively impacting the quality of education and student outcomes. In recent years, mindfulness-based interventions have been shown to promote well-being and reduce stress among healthy adults. In particular, mindfulness-based interventions enhance emotion regulation and reduce psychological distress. One such program specifically designed to address teacher stress is Cultivating Awareness and Resilience in Education (CARE). The present study examined teachers' self-reported data collected at three time points over two consecutive school years as part of a randomized controlled trial of CARE. The study involved 224 teachers in 36 elementary schools in high poverty areas of New York City. Teachers were randomly assigned within schools to receive CARE or to a waitlist control group. This study builds on previous experimental evidence of the impacts of CARE on teacher self-reported outcomes for this sample of teachers within one school year (Jennings et al., 2017). Results indicate that at the third assessment point (9.5 months after participating in the program), CARE teachers showed continued significant decreases in psychological distress, reductions in ache-related physical distress, continued significant increases in emotion regulation and some dimensions of mindfulness. Findings indicate that teachers who participated in mindfulness-based professional development through CARE reported both sustained and new benefits regarding their well-being at a follow-up assessment almost one-year post-intervention compared to teachers in the control condition. Implications for further research and policy are discussed.
An Even Playing Field: The Goal of Gender Equity in World Cup Soccer

The United States Women’s National Soccer Team has dominated the sport since the inaugural Women’s World Cup in 1991. Despite its success on the field, however, the team has had a contentious relationship over the last three decades with the United States Soccer Federation, the sport’s governing body in the United States. The ongoing discord between the Women’s National Team and the U.S. Soccer Federation culminated in March 2019, when twenty-eight players from the team filed a lawsuit alleging that the Federation had violated the Equal Pay Act by paying them less than it paid members of the Men’s National Team. This Article traces the history of strife between the Women’s National Team and the U.S. Soccer Federation. The troubled relationship is a result of the mismatch between the team’s superior results but lower pay compared to the Men’s National Team. This mismatch has its roots in competing legal and societal forces. On the one hand, Title IX caused an explosion in the participation rate for women’s soccer in the United States, which has led to the Women’s National Team’s unprecedented success. On the other hand, with the exception of the World Cup finals every four years, the viewership market for women’s soccer remains much smaller than the market for men’s soccer, which has resulted in lower revenue generation by the Women’s National Team compared to the far less successful Men’s National Team. After explaining the history and cause of the turmoil between the Women’s National Team and the U.S. Soccer Federation, this Article analyzes the merits of the players’ Equal Pay Act claim. The Article contends that the Federation has the stronger position on the merits of the claim, but further argues that the Federation should renegotiate the Women’s National Team’s collective bargaining agreement in light of the Federation’s mission of “gender equality.” The Article proposes specific principles that might guide that renegotiation and lead to a successful resolution of the long-standing tensions between the Women’s National Team and the U.S. Soccer Federation.
Household chaos, family routines, and young child movement behaviors in the U.S. during the COVID-19 outbreak: a cross-sectional study.

The home environment is an important facilitator of young child movement behaviors, including physical activity (PA), sleep, and screen-time. Household chaos, characterized by crowding, noise, and disorder in the home, may hinder efforts to obtain adequate amounts of movement behaviors. The COVID-19 outbreak impacted many families, and social distancing during this time may create conditions for more household chaos. Family routines can help establish order in the home and encourage an appropriate balance of movement behaviors, such as less screen-time and more sleep. The purpose of this study was to evaluate the association between household chaos and young child movement behaviors during the COVID-19 outbreak in the United States, and the role of family routines in this relationship. A national online survey including 1836 mothers of preschoolers (3.0–5.9 years) was conducted during May 2020. Mothers reported demographic characteristics, household chaos, family routines, and the preschooler’s movement behaviors during the outbreak. Mothers completed a household chaos questionnaire and were grouped into chaos categories (low, moderate/low, moderate/high, and high) for analysis. Linear regression was used to assess the association between chaos category, family routines, and movement behaviors with adjustment for covariates. Mothers were 35.9 ± 4.1 years of age, middle income (47.8%), and preschoolers were 3.8 ± 0.8 years of age. Most mothers reported their preschooler was less physically active (38.9%), slept the same amount of time (52.1%), and increased their screen-time (74.0%) after the COVID-19 outbreak. Preschoolers in the high chaos households performed less total PA (β = − 0.36 days/week, 95% CI:-0.62 to − 0.09, p = 0.008), slept less (β = − 0.42 h, 95% CI:-0.59 to − 0.25, p = 0.001) and had more screen-time (β = 0.69 h, 95% CI:0.45 to 0.92, p = 0.001) compared to those in low chaos households. In most chaos categories, having a bed-time ritual was related to more child sleep, and mothers who viewed routines as “less/not important” reported more preschooler screen-time compared to mothers who viewed routines as “very important”. Promoting bed-time rituals and prioritizing routines, even somewhat, may be related to an improved balance of child movement behaviors. Innovative measures are needed to support families during periods of disruption such as that experienced in the COVID-19 pandemic.
Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression

During early embryogenesis, the vertebrate embryo extends from anterior to posterior because of the progressive addition of cells from a posteriorly localized neuromesodermal progenitor (NMp) population. An autoregulatory loop between Wnt and Brachyury/Tbxt is required for NMps to retain mesodermal potential and, hence, normal axis development. We recently showed that Hox13 genes help to support body axis formation and to maintain the autoregulatory loop, although the direct Hox13 target genes were unknown. Here, using a new method for identifying in vivo transcription factor-binding sites, we identified more than 500 potential Hox13 target genes in zebrafish. Importantly, we found two highly conserved Hox13-binding elements far from the tbxta transcription start site that also contain a conserved Tcf7/Lef1 (Wnt response) site. We show that the proximal of the two elements is sufficient to confer somitogenesis-stage expression to a tbxta promoter that, on its own, only drives NMp expression during gastrulation. Importantly, elimination of this proximal element produces shortened embryos due to aberrant formation of the most posterior somites. Our study provides a potential direct connection between Hox13 and regulation of the Wnt/Brachyury loop.
Hypertensive encephalopathy

The term hypertensive encephalopathy should be reserved for patients with diffuse cerebral effects of precipitous and sustained rises in blood pressure that reverse when blood pressure is lowered and are not due to infarction or hemorrhage. The definitive diagnosis of this syndrome depends on accurate exclusion of other causes that may be associated with elevated blood pressure and neurologic deficits. Treatment is aimed at preventing or limiting target organ (brain) damage. Therapy should be individualized but centered on reducing the mean arterial blood pressure within a period of minutes to 2 hours, by no more than 20% to 25% or to a diastolic blood pressure of 100 to 110 mm Hg (whichever is higher), using short-acting intravenous agents. Oral or sublingual agents should generally be avoided in hypertensive encephalopathy because they are more likely to cause precipitous falls in blood pressure.
Study of the reactions 118Sn(d, t) and 98Mo(d, t): (I). Spectroscopy of 117Sn and 97Mo

Abstract The vector analyzing power and differential cross section have been measured at a deuteron energy of 12.0 MeV for 118 Sn ( d , t ) transitions to six states of 117Sn (Ex = 0.0, 0.16, 0.31, 0.71, 1.02 and 1.18 MeV), for 98 Mo ( d , t ) transitions to eight states of 97Mo (Ex = 0.0, 0.68, 0.72, 0.89, 1.12, 1.28, 2.39 and 2.52 MeV), and for 118 Sn ( d , d ) and 98 Mo ( d , d ) . Deuteron optical model potentials were obtained from analysis of the elastic scattering measurements, and were used in a DWBA analysis of the ( d , t ) results. Comparison of the measurements and DWBA predictions for σ(θ) and for iT11(θ) allows unambiguous determination of tln and jn for all 118Sn(d, t) and most 98Mo(d, t) transitions. Differences in the triton energy relative to the Coulomb barrier cause marked qualitative differences in the measured cross sections and analyzing powers between 118 Sn ( d , t ) and 98 Mo ( d , t ) transitions of the same ln and jn.
Enhanced coupling in Si 3 N 4 slot-mode optomechanical crystals via stress tuning

We demonstrate Si 3 N 4 slot-mode optomechanical crystals with optical Qs up to 1.65 × 105 and mechanical frequencies around 3.4 GHz. Tensile stress tunes gap widths down to 24 nm, enhancing coupling and enabling radiation-pressure-driven self-oscillation.
Analysis of the proteoglycans synthesized by human bone cells in vitro.

Proteoglycans were isolated by ion-exchange chromatography from the extracted cell layer and culture medium of human bone cell cultures following incubation in the presence of [35S]sulfate and [3H]leucine. On sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), the synthesized proteoglycans consisted of at least five polydisperse species having median apparent Mr = 600,000, 400,000, 270,000, 135,000 and 40,000. When chromatographed further on octyl-Sepharose CL-4B, the proteoglycans of the cell layer resolved into three peaks. The unbound fraction (peak cell layer-I) contained a 40,000 species consisting of a single glycosaminoglycan chain with or without peptide. Peak cell layer-II contained three sulfated species on electrophoresis: a 600,000 species uniformly distributed across the peak, a 135,000 species enriched in the ascending limb (similar to bone PG-I as described previously), and a 270,000 species (similar to bone PG-I) enriched in the descending limb. Peak cell layer-III, eluting at 0.2% Triton X-100, was highly enriched in a 400,000 proteoglycan component. When media proteoglycans were chromatographed on octyl-Sepharose, two labeled peaks were found. Peak medium-I (unbound) contained a species exhibiting electrophoretic mobility similar to that of the 400,000 species present in peak cell layer-III. Peak II of the culture medium (medium-II) was apparently identical to that of peak cell layer-II, containing the 600,000, 270,000 and 135,000 species. No appreciable 40,000 species was observed in the medium. Treatment of the 600,000 species with either chondroitinase ABC or ACII generated a core protein preparation with bands of 390,000 and 340,000 on SDS gels. Neither the intact nor the chondroitinase ABC-treated 600,000 species was immunoprecipitated by a purified, polyclonal antiserum raised against the core protein of the large chondroitin sulfate proteoglycan of human articular cartilage. Treatment of the 270,000 and 135,000 proteoglycans with chondroitinase ABC, but not ACII, generated a core protein preparation with bands of 52,000 and 49,000 on SDS gels, indicating that they were dermatan sulfate-containing species. The 400,000 species contained both heparan sulfate and chondroitin sulfate, in approximately a 3:1 labeling ratio. This species changed in electrophoretic mobility following treatment with chondroitinase ABC, heparatinase, or both enzymes in combination, which suggested that it may be a hybrid proteoglycan (i.e. both types of glycosaminoglycan chain on the same core protein).(ABSTRACT TRUNCATED AT 400 WORDS)
Scaling properties of neuronal avalanches are consistent with critical dynamics

Complex systems, when poised near a critical point of a phase transition between order and disorder, exhibit a dynamics comprising a scale-free mixture of order and disorder which is universal, i.e. system-independent (1-5). It allows systems at criticality to adapt swiftly to environmental changes (i.e., high susceptibility) as well as to flexibly process and store information. These unique properties prompted the conjecture that the brain might operate at criticality (1), a view supported by the recent description of neuronal avalanches in cortex in vitro (6-8), in anesthetized rats (9) and awake primates (10), and in neuronal models (11-16). Despite the attractiveness of this idea, its validity is hampered by the fact that its theoretical underpinning relies solely on the replication of sizes and durations of avalanches, which reflect only a portion of the rich dynamics found at criticality. Here we show experimentally five fundamental properties of avalanches consistent with criticality: (1) a separation of time scales, in which the power law probability density of avalanches sizes s, P(s) and the lifetime distribution of avalanches are invariant to slow, external driving; (2) stationary P(s) over time; (3) the avalanche probabilities preceding and following main avalanches obey Omori law (17, 18) for earthquakes; (4) the average size of avalanches following a main avalanche decays as a power law; (5) the spatial spread of avalanches has a fractal dimension and obeys finite-size scaling. Thus, neuronal avalanches are a robust manifestation of criticality in the brain.
Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle

Mixed lineage leukemias (MLLs) are histone H3 at lysine 4 (H3K4)-specific methylases that play a critical role in regulating gene expression in humans. As chromatin condensation, relaxation and differential gene expression are keys to correct cell cycle progression, we analyzed the dynamic association of MLL and H3K4 trimethylation at different stages of the cell cycle. Interestingly, MLL1, which is normally associated with transcriptionally active chromatins (G1 phase), dissociates from condensed mitotic chromatin and returns at the end of telophase when the nucleus starts to relax. In contrast, H3K4 trimethylation mark, which is also normally associated with euchromatins (in G1), remains associated, even with condensed chromatin, throughout the cell cycle. The global levels of MLL1 and H3K4 trimethylation are not affected during the cell cycle, and H3Ser28 phosphorylation is only observed during mitosis. Interestingly, MLL target homeobox-containing (Hox) genes (HoxA5, HoxA7 and HoxA10) are differentially expressed during the cell cycle, and the recruitment of MLL1 and H3K4 trimethylation levels are modulated in the promoter of these Hox genes as a function of their expression. In addition, down-regulation of MLL1 results in cell cycle arrest at the G2/M phase. The fluctuation of H3K4 trimethylation marks at specific promoters, but not at the global level, indicates that H3K4 trimethylation marks that are present in the G1 phase may not be the same as the marks in other phases of the cell cycle; rather, old marks are removed and new marks are introduced. In conclusion, our studies demonstrate that MLL1 and H3K4 methylation have distinct dynamics during the cell cycle and play critical roles in the differential expression of Hox genes associated with cell cycle regulation.
Rapid integration and testing of business solutions

Rapid application development (RAD) methodology is increasingly being used by software development units across BT as a means of delivering maximum functionality in the shortest time thereby allowing the company to respond quickly to new business opportunities. DSDM (Dynamic Systems Development Method) has emerged as the UK and international standard for RAD and is currently being used by a number of development units within BT. For a number of reasons, some of the fundamental tenets of DSDM are proving difficult to use for small to medium size multimedia and business solution projects. This paper looks at how the Advanced Service Management Unit of BT‘s Systems Integration Department has responded to this situation and formulated a hybrid approach to testing known as ‘SI-Rapid‘.
Honest-Services Fraud: The Supreme Court Defuses the Government's Weapon of Mass Discretion in Skilling v. United States

For over two decades federal prosecutors wielded a weapon of mass discretion in their fight against corruption: the honest-services fraud statute. Although prosecutors welcomed the statute's ambiguous text, judges, defendants, and scholars struggled to answer a number of difficult constitutional questions arising from the honest-services fraud theory. In 2010, the Supreme Court used Skilling v. United States - a case that chronicles the events that led to the epic collapse of former energy giant Enron - to defuse the Government’s “weapon of mass discretion” by limiting honest-services fraud to schemes involving bribery or kickbacks, thereby excluding more subtle forms of dishonesty, such as undisclosed self-dealing, from falling within the statute's reach. This Comment discusses the case’s impact on the fallen Enron CEO’s fight for freedom, in addition to its impact on two other petitioners who successfully challenged the honest-services fraud statute in 2010. I also examine the rights of the defendants whose convictions or plea agreements were premised on an application of the statute now declared unconstitutional, as well as analyze the decision’s impact on pending and future cases of honest-services fraud. Finally, I explain why Congress will likely supersede Skilling by amending § 1346 to expressly criminalize schemes involving an individual’s failure to disclose their self-dealing; analyze the proposed “Honest Services Restoration Act” (HSRA), which was drafted to accomplish this goal; and conclude that, although not perfect, the proposed language contained in the HSRA adequately addresses the major constitutional concerns surrounding the use of honest-services fraud to prosecute undisclosed self-dealing.
Reconstructing 7000 years of North Atlantic hurricane variability using deep-sea sediment cores from the western Great Bahama Bank

Q1 (ENSO)) show abrupt changes around 6000 yrs B.P., but most coastal sedimentary records do not span this time period. Establishing longer records is essential for understanding mid-Holocene patterns of storminess and their climatic drivers, which will lead to better forecasting of how climate change over the next century may affect tropical cyclone frequency and intensity. Storms are thought to be an important mechanism for transporting coarse sediment from shallow carbonate platforms to the deep-sea, and bank-edge sediments may offer an unexplored archive of long-term hurricane activity. Here, we develop this new approach, reconstructing more than 7000 years of North Atlantic hurricane variability using coarse-grained deposits in sediment cores from the leeward margin of the Great Bahama Bank. High energy event layers within the resulting archive are (1) broadly correlated throughout an offbank transect of multi-cores, (2) closely matched with historic hurricane events, and (3) synchronous with previous intervals of heightened North Atlantic hurricane activity in overwash reconstructions from Puerto Rico and elsewhere in the Bahamas. Lower storm frequency prior to 4400 yrs B.P. in our records suggests that precession and increased NH summer insolation may have greatly limited hurricane potential intensity, outweighing weakened ENSO and a stronger West African Monsoon—factors thought to be favorable for hurricane development.
In vivo response to an implanted shape memory polyurethane foam in a porcine aneurysm model

Cerebral aneurysms treated by traditional endovascular methods using platinum coils have a tendency to be unstable, either due to chronic inflammation, compaction of coils, or growth of the aneurysm. We propose to use alternate filling methods for the treatment of intracranial aneurysms using polyurethane-based shape memory polymer (SMP) foams. SMP polyurethane foams were surgically implanted in a porcine aneurysm model to determine biocompatibility, localized thrombogenicity, and their ability to serve as a stable filler material within an aneurysm. The degree of healing was evaluated via gross observation, histopathology, and low vacuum scanning electron microscopy imaging after 0, 30, and 90 days. Clotting was initiated within the SMP foam at time 0 (<1 h exposure to blood before euthanization), partial healing was observed at 30 days, and almost complete healing had occurred at 90 days in vivo, with minimal inflammatory response.