cssi/SciSciGPT-SciSciNet huggingface dataset:
Income of the Elderly Population: 2001

This paper examines the income of the elderly population in the United States by reviewing data from the U.S. Census Bureau's Current Population Survey. The PDF for the above title, published in the June 2003 issue of EBRI Notes, also contains the fulltext of another June 2003 EBRI Notes article abstracted on SSRN: "National Health Spending Up 8.7 Percent Between 2000-2001; Spending for Health Care Will Continue to Grow."
Frequency Domain Characterization of Mass Air Flow Sensors

This paper presents a frequency domain approach to the experimental definition of the sensor dynamic response. The resulting sensor model is easy to implement and to interpret. It is useful both to the sensor engineer for sensor design and understanding, and to the power-train system engineer for engine control system design and analysis
Myelotoxicity and Dose Intensity of Chemotherapy: Reporting Practices From Randomized Clinical Trials

Delivery of cancer chemotherapy is often limited by myelotoxicity, primarily neutropenia. As part of an effort to create a model to predict the risk of chemotherapy-induced neutropenia, we reviewed the reports of randomized clinical trials with more than 50 patients per arm in early-stage breast cancer (ESBC) and non-Hodgkin's lymphoma (NHL) published between 1990 and 2000. We observed that no hematologic toxicity data were reported in 39% and 34% of the ESBC and NHLtrials, respectively. The remaining trials reported on hematologic toxicity in 16 different ways. When reported, rates of neutropenia, leukopenia, and hematotoxicity varied widely with the same and similar chemotherapy regimens. Dose-intensity data were not reported in 39% and 54% of ESBC and NHL trials, respectively. The majority of the remaining studies reported incomplete dose-intensity data such as percentages of patients completing all cycles or receiving a given percentage of planned dose intensity. Only 28% reported the mean or median relative dose intensity received by patients. Based on this review, we conclude that current practices for reporting chemotherapy treatments are inadequate for describing the risk of chemotherapy to patients or for quantitatively assessing the risk of treatment alternatives. We recommend that standard procedures for documenting and reporting hematologic toxicity and dose intensity in cancer chemotherapy trials be required for publication of chemotherapy trials.
Age Bias in the Evaluation of Achievement: What Determines?

This study hypothesized that there would be no sex or age biases in judged quality of a newspaper article previously rated sex- and age-neutral as to likelihood of authorship and readership. Undergraduates (53 males, 73 females) read a biographical resume varying author age and sex and either a well-written or poorly-written version of an article on gardening. A 2 (stimulus age) x 2 (stimulus sex) x 2 (article quality) factorial multivariate analysis of variance found only a significant main effect of article quality and, as predicted, no effects of stimulus age or sex upon article evaluation or authorship expectancy.
Develop Scientifically and Strengthen Construction to Establish a First-class University of Finance and Economics

The scientific view of development is the leading thought for the universities and colleges to develop scientifically,to strengthen construction,and to improve the education level.So the universities of finance and eco- nomics ought to establish themselves into first-class by probing into the management style,improving the research level,improving the teaching quality of undergraduate course and by establish a first-class faculty.
Artificial Zinc Finger Nucleases for DNA Cloning

DNA cloning is fundamental for modern cell research and biotechnology. Various restriction enzymes have been isolated, characterized, and purified to facilitate the digestion and ligation of DNA molecules of different origins. Nevertheless, the very small numbers of enzymes capable of digesting novel and long DNA sequences and the tedious and nearly impossible task of re-engineering existing enzymes with novel specificities greatly limit the use of restriction enzymes for the construction of complex and long DNA molecules. Zinc finger nucleases (ZFNs) - hybrid restriction enzymes that can be tailor made for the digestion of both native and artificial DNA sequences - offer a unique opportunity for expanding the repertoire of restriction enzymes useful for various DNA cloning tasks. Here we present protocols for the assembly, expression, and purification of cloning-grade ZFNs and their use for DNA cloning. We focus our discussion on the assembly of a dual-cassette plant transformation vector, as an example of a task that is nearly impossible to perform using the current collection of naturally occurring and recombinant 6-8 bp long restriction enzymes.
Bourgeois Radicals: “The White Man’s Burden Has Not Been Very Heavy”

No country like the Union of South Africa can be recognized as capable of exercising a colonial mandate. – NAACP Colonial Conference, 1945 The NAACP’s postwar agenda was firmly established at the April 1945 Colonial Conference. That meeting, in many ways, generated the Association’s road map to colonial liberation: South Africa (South West Africa); Italy (Libya, Eritrea, Somalia); the Netherlands (Indonesia); France (Morocco and Tunisia); and Britain (Kenya). With a strategy similar to the methodical case-by-case approach it had used to expose the sham of separate but equal, the NAACP recognized that the way each colony was governed presented a prime opportunity to strategically undermine and delegitimize the rationales that had, for too long, transformed the brutality of white supremacy into the narrative of benevolent colonial rule. South West Africa (current day Namibia), in particular, was a testament to how far the myth of the “white man’s burden” had fallen short. The colony had been a mandate under the old League of Nations system and, as such, was a “sacred trust of civilization” administered, in this case, by South Africa. That jarring juxtaposition – a sacred trust held by a racially repressive regime – led the NAACP to emphasize two key principles that were essential for challenging the viability of colonialism in a world birthed by the Atlantic and UN Charters.
Facebook Privacy Attitudes: A Comparison of Two Minority Groups

Because of Facebook’s ubiquitous nature, users who fail to properly configure their Facebook account privacy settings could be unintentionally revealing personal information to millions of people. This study analyzes data collected from African American and Hispanic college students regarding Facebook privacy setting attitudes and use. The findings indicate African American students have been members of Facebook longer and have more “Friends” than Hispanic students. Both ethnic groups spend about the same amount of time on Facebook during each session, although Hispanics log on more frequently. Virtually all the students claim awareness and use Facebook privacy settings. Hispanics have more restrictive Facebook privacy settings than African Americans. Neither ethnic group trusts Facebook to protect privacy, but African Africans show less concern while Hispanics indicate greater worry about Facebook privacy and data security. Both ethnic groups are more concerned about Internet privacy than Facebook privacy, Hispanics significantly more so.
Growth of Indicator, Pathogenic and Psychrotrophic Bacteria in Mechanically Separated Beef, Lean Ground Beef and Beef Bone Marrow1

Growth of Escherichia coli , Salmonella anatum , Staphylococcus aureus , Clostridium perfringens and naturally occurring psychrotrophs in mechanically separated beef (MSB), lean ground beef (LGB) and beef bone marrow (BBM) was studied. Six good grade steers were slaughtered and samples of MSB, LGB and BBM were prepared under proper sanitary care. Six hundred grams of each sample were collected; 100 g were used for chemical analysis. The remaining 500 g were divided into 10-g portions, each mixed with 10 ml of water and either frozen to -20°C or used immediately for bacteriological analysis. For growth studies, samples were inoculated with E. coli or one of the pathogens, incubated at 37°C up to 24 h and enumerated for colony forming units (CFU) on specific selective agar plates. During the first 8 h of incubation, E. coli and S. anatum multiplied rapidly in MSB and LGB but rather slowly in BBM. By 24 h, both species had multiplied to the same population level. Initial growth of S. aureus was rapid in MSB and LGB, but by 24 h its number was higher in LGB than in MSB or BBM. C. perfringens grew faster in LGB and slower in BBM during the 24-h period. Growth of psychrotrophs was determined by incubating the materials at 10, 7 and 3°C up to 10 d. The psychrotrophs grew fastest in MSB and slowest in LGB at all three temperatures, especially at 3°C. Rapid growth of various bacteria in MSB should be considered in its production, storage and subsequent use.
Charged current neutrino interactions in hot and dense matter

We derive the charged current absorption rate of electron and antielectron neutrinos in dense matter using a fully relativistic approach valid at arbitrary matter degeneracy. We include mean field energy shifts due to nuclear interactions and the corrections due to weak magnetism. The rates are derived both from the familiar Fermi's golden rule and from the techniques of finite temperature field theory, and are shown to be equivalent. In various limits, these results can also be used to calculate neutral current opacities. We find that some pieces of the response have been left out in previous derivations and their contribution at high density can be significant. Useful formulas and detailed derivations are presented and we provide a new open-source implementation of these opacities for use in radiation hydrodynamic simulations of core-collapse supernovae and neutron star mergers.
Analysis of intraosseous blood samples using an EPOC point of care analyzer during resuscitation.

Abstract Background In the early phases of resuscitation in a critically ill patient, especially those in cardiac arrest, intravenous (IV) access can be difficult to obtain. Intraosseous (IO) access is often used in these critical situations to allow medication administration. When no IV access is available, it is difficult to obtain blood for point of care analysis, yet this information can be crucial in directing the resuscitation. We hypothesized that IO samples may be used with a point of care device to obtain useful information when seconds really do matter. Methods Patients presenting to the emergency department requiring resuscitation and IO placement were prospectively enrolled in a convenience sample. 17 patients were enrolled. IO and IV samples obtained within five minutes of one another were analyzed using separate EPOC® point of care analyzers. Analytes were compared using Bland Altman Plots and intraclass correlation coefficients. Results In this analysis of convenience sampled critically ill patients, the EPOC® point of care analyzer provided results from IO samples. IO and IV samples were most comparable for pH, bicarbonate, sodium and base excess, and potentially for lactic acid; single outliers for bicarbonate, sodium and base excess were observed. Intraclass correlation coefficients were excellent for sodium and reasonable for pH, pO2, bicarbonate, and glucose. Correlations for other variables measured by the EPOC® analyzer were not as robust. Conclusion IO samples can be used with a bedside point of care analyzer to rapidly obtain certain laboratory information during resuscitations when IV access is difficult.
Comparison of electrospun and solvent cast polylactic acid (PLA)/poly(vinyl alcohol) (PVA) inserts as potential ocular drug delivery vehicles.

Abstract Purpose The purpose of this work was to develop, characterize and compare electrospun nanofiber inserts (ENIs) and solvent cast polymeric inserts (SCIs) for ocular drug delivery. Methods ENI and SCI of 1%, 5% and 10% w/w dexamethasone were fabricated using a blend of poly-lactic acid (PLA) and poly-vinyl alcohol (PVA). Inserts were characterized for morphology, thickness, pH, drug content, drug crystallinity, in vitro drug release, sterility, dimethylformamide (DMF) and chloroform content, and cytotoxicity. Results The thickness of 1%, 5%, and 10% dexamethasone-loaded ENIs were found to be 50 μm, 62.5 μm, and 93.3 μm, respectively, with good folding endurance. SCIs were brittle, with thickness values > 200 μm. Drug release rates from 1%, 5% and 10% ENIs were found to be 0.62 μg/h, 1.46 μg/h, and 2.30 μg/h, respectively, while those from SCIs were erratic. DMF content in ENIs and SCIs were 0.007% w/w and 0.123% w/w, respectively, while chloroform was not detected. No cytotoxicity was observed from ENIs in cultured bovine corneal endothelial cells for up to 24 h. Conclusion We conclude that ENIs are better than SCIs and could be utilized as a potential delivery system for treating anterior segment ocular diseases.
Clinical Decision-Making in Patients with Variant of Uncertain Significance in BRCA1 or BRCA2 Genes.

How diagnosis with a variant of uncertain significance (VUS) in a BRCA gene impacts clinical decision-making is not well known. We queried for all patients attending Mayo Clinic Rochester from 2004 to 2016 who tested positive for BRCA1 or BRCA2 VUS and reviewed patient management choices. Groups were compared by using Wilcoxon rank-sum and Chi-square tests. We identified 97 patients (95 females, 2 males) with BRCA VUS. For patients without cancer history (n = 20), 80% had a mother or sister with breast cancer, and median Tyrer-Cuzick (IBIS) lifetime breast cancer risk score was 27% (range 16–62%). Management included bilateral prophylactic mastectomy (BPM) in 39%, where choice for BPM was significantly associated with IBIS score (median 32 vs. 24%, p = 0.02) and first-degree family history of breast cancer (100 vs. 64%, p = 0.03) but not Gail score or total number of family members with cancer. For patients with breast cancer who had known VUS status prior to surgery (n = 9), the rate of contralateral prophylactic mastectomy (CPM) was 22% compared with 25% without known VUS and 83% with known BRCA pathogenic mutation. In 21 of 97 (22%) patients, the BRCA VUS has been reclassified (95% benign, 5% deleterious). BRCA VUS carriers with cancer elected surgical choices similar to average-risk breast cancer patients. However, VUS carriers without cancer had high rates of BPM, associated with first-degree family history and IBIS score. Over time, a significant proportion of BRCA VUS were reclassified, illustrating the importance of appropriate counseling regarding VUS.
Co-MEAL: Cost-Optimal Multi-Expert Active Learning Architecture for Mobile Health Monitoring

Mobile health monitoring plays a central role in a variety of health-care applications. Using mobile technology, health-care providers can access clinical information and communicate with subjects in real-time. Due to the sensitive nature of health-care applications, these systems need to process physiological signals highly accurately. However, as mobile devices are employed in dynamic environments, the accuracy of a machine learning model drops whenever a change in configuration of the system occurs. Therefore, data mining and machine learning techniques that specifically address challenges associated with dynamic environments (e.g. different users, signal heterogeneity) are needed. In this paper, using active learning as an organizing principle, we propose a cost-optimal multiple-expert architecture to adapt a machine learning model (e.g. classifier) developed in a given context to a new context or configuration. More specifically, in our architecture, a system's machine learning model learns from experts available to the system (e.g. another mobile device, human annotator) while minimizing the cost of data labeling. Our architecture also exploits collaboration between experts to enrich their knowledge which in turn decreases both cost and uncertainty of data labeling in future steps. We demonstrate the efficacy of the architecture using a publicly available dataset on human activity. We show that the accuracy of activity recognition reaches over 85% by labeling only 15% of unlabeled data. At the same time, the number of queries from human expert is reduced by up to 82%.
Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3.

Purpose To elucidate functions of wild-type myocilin, a secreted glycoprotein associated with glaucoma. Methods Lysates of mouse eyes were used for immunoprecipitation with affinity-purified antibodies against mouse myocilin. Shotgun proteomic analysis was used for the identification of proteins interacting with myocilin. Colocalization of myocilin and tissue inhibitor of metalloproteinases 3 (TIMP3) in different eye structures was investigated by a multiplex fluorescent in situ hybridization and immunofluorescent labeling with subsequent confocal microscopy. Matrix metalloproteinase 2 (MMP2) activity assay was used to test effects of myocilin on TIMP3 inhibitory action. Results TIMP3 was identified by a shotgun proteomic analysis as a protein that was coimmunoprecipitated with myocilin from eye lysates of wild-type and transgenic mice expressing elevated levels of mouse myocilin but not from lysates of transgenic mice expressing mutated mouse myocilin. Interaction of myocilin and TIMP3 was confirmed by coimmunoprecipitation of myocilin and TIMP3 from HEK293 cells transiently transfected with cDNAs encoding these proteins. The olfactomedin domain of myocilin is essential for interaction with TIMP3. In the eye, the main sites of myocilin and TIMP3 colocalization are the trabecular meshwork, sclera, and choroid. Using purified proteins, it has been shown that myocilin markedly enhanced the inhibitory activity of TIMP3 toward MMP2. Conclusions Myocilin may serve as a modulator of TIMP3 activity via interactions with the myocilin olfactomedin domain. Our data imply that in the case of MYOCILIN null or some glaucoma-causing mutations, inhibitory activity of TIMP3 toward MMP2 might be reduced, mimicking deleterious mutations in the TIMP3 gene.
Chapter 1 – Getting Started in Python

This chapter introduces the reader to the basics of programming in Python version 3. Starting from a Hello World example, the concepts of comments, errors, and code indentation in Python are introduced. The manipulation of numerical values in Python is then demonstrated, including complex arithmetic. The concept of strings is used to introduce the notion of operator overloading. The reader is then shown how to accept keyboard input into a Python program. The chapter concludes with a discussion of branching and iteration in Python with examples.
MEBook: Multimedia Social Greetings Intervention for Children with Autism Spectrum Disorders

Autism spectrum disorder (ASD) is a developmental disorder that impairs the development of social and communication skills. There is evidence that children with ASD prefer images of self over others [1] . These studies may explain the effectiveness of video self-modeling (VSM), an evidence-based ASD intervention in which one learns by watching oneself on video performing a target behavior. VSM content is difficult to create as target behaviors are sporadic. In this paper, we propose the MEBook system which uses a Kinect sensor to inject self-images into a gesture-based social narrative to teach children with ASD proper greeting behaviors. MEBook consists of two components. The first component is a social narrative. A social narrative is an animated story about the main character meeting and greeting different cartoon characters in a particular setting. Self-modeling is achieved by first replacing the main characters face with an image of the learner, and then animating the learner's body and voice to match the narration. The second component is a positive reinforcement practice session in which the subject is prompted to greet different cartoon characters. Through depth-based body posture tracking, proper greeting behaviors are recognized and immediately reinforced with praise and visual confetti. Novel computational multimedia tools are proposed to turn video recordings of successful attempts into VSM content, thereby alleviating the tedious production process. A multiple-baseline single subject pilot study has been conducted and the preliminary results show that MEBook is potentially effective in teaching greeting behaviors to children with ASD.
Processional Barques from the Tomb of Tutankhamun (KV62)

Ancient Egyptian processional (portable) barques took various forms, not all of which included shrines for cult images. Some of the model boats found in Tutankhamun’s tomb resemble and were probably originally shrineless processional barques used in festivals, rather than funerary models of solar barques in the usual sense.
Charge splitters and charge transport junctions based on guanine quadruplexes

Self-assembling circuit elements, such as current splitters or combiners at the molecular scale, require the design of building blocks with three or more terminals. A promising material for such building blocks is DNA, wherein multiple strands can self-assemble into multi-ended junctions, and nucleobase stacks can transport charge over long distances. However, nucleobase stacking is often disrupted at junction points, hindering electric charge transport between the two terminals of the junction. Here, we show that a guanine-quadruplex (G4) motif can be used as a connector element for a multi-ended DNA junction. By attaching specific terminal groups to the motif, we demonstrate that charges can enter the structure from one terminal at one end of a three-way G4 motif, and can exit from one of two terminals at the other end with minimal carrier transport attenuation. Moreover, we study four-way G4 junction structures by performing theoretical calculations to assist in the design and optimization of these connectors. Guanine-quadruplex motifs form multi-ended DNA junctions that transport electrical charges with minimal losses.
Associations Between Maternal Gatekeeping and Fathers’ Parenting Quality

High-quality father involvement in childrearing is associated with positive child outcomes. Yet, variability between fathers in parenting quality remains. The present study examined associations between maternal gatekeeping and fathers’ observed parenting quality in 182 dual-earner families who transitioned to parenthood in 2008–2009. Maternal gatekeeping, or beliefs and behaviors that may serve to discourage (gate close) or encourage (gate open) father involvement in childrearing, was measured using fathers’ reports at 3- and 9-months postpartum. Fathers’ parenting quality was assessed during a brief observational task at 3- and 9-months postpartum. A cross-lagged structural equation model, which included repeated measures of maternal gate closing, gate opening, and fathers’ parenting quality (i.e., sensitivity, detachment, and positive regard) at 3- and 9-months postpartum, revealed associations between maternal gatekeeping and fathers’ parenting quality. In particular, fathers who experienced greater gate closing at 3-months postpartum showed greater relative declines in parenting quality at 9-months postpartum. Of note, maternal gate opening at 3-months postpartum was not associated with fathers’ parenting quality at 9-months postpartum. Additionally, paths from fathers’ parenting quality at 3-months postpartum to maternal gatekeeping at 9-months postpartum were not significant. This is the first study to examine longitudinal associations between maternal gatekeeping and fathers’ parenting quality.
Targeting the Effect Site with a Computer Controlled Infusion Pump

Over the last decade computer controlled infusions have been used to rapidly achieve and maintain constant plasma drug concentrations for drugs having pharmacokinetics characterized by polyexponential disposition functions. For most drugs the plasma is not the site of drug effect. Thus, targeting the plasma drug concentration may not be a rational approach to optimal drug therapy. Drawing on previously described effect site models, an algorithm is developed for computer controlled infusion pumps to target the apparent concentration at the site of drug effect, rather than the concentration in the plasma. Simulations are based on the pharmacokinetics and plasma-effect site equilibration delay that have been reported for fentanyl, an intravenous opioid commonly used in anesthetic practice.
Use of Ontologies in Software Engineering.

This paper surveys the role ontologies might play in the whole software development life cycle. Use of ontologies in each phase of software development yields competitive advantage over traditional approach enabling greater information sharing and reuse. In this survey paper, we present a concise description of various ontology-based approaches in Software Engineering ordered by their position in the Software Engineering life cycle. We also report ontology editor tool Protege as part of our survey.
Autoradiography with the Electron Microscope: Experimental Techniques and Considerations Using Plant Tissues

Considerable interest in autoradiography has been stimulated by the development of this technique for electron microscopy. However, the subsequent upsurge in enthusiasm has often resulted in overconfidence in the technique and sometimes an unfortunate lack of discrimination in the interpretation of its results. This has led to a profound and often justified scepticism among many more discerning workers who recognize the severe limitations of the methods used today. Autoradiography is not a panacea which will make possible the identification of any stray cytoplasmic vesicle or inclusion; like any other scientific method it can only yield valuable results when its limitations are clearly recognized, stated and evaluated where possible. More recently, several elegant and important autoradiographic experiments have been published illustrating these limitations and methods of evaluating them (see Section 6.15).
Enhancing immunotherapy of STING agonist for lymphoma in preclinical models

Direct activation of tumor infiltrating antigen-presenting cells (APCs) by intratumoral injection of STING agonists (STINGa) leads to regression of the treated lymphoma tumor. Because STING activation induces apoptosis in lymphoma cells in vitro, we distinguished between the direct therapeutic vs the indirect immunotherapeutic properties of STINGa in vivo. Employing wild-type or STING knockout hosts bearing either wild-type or STING knockout tumor cells, we demonstrated that local tumor regression is totally dependent on STING expression by the host and is therefore immune mediated. However, distant untreated tumors are weakly affected after injection of STINGa to a single tumor site. Therefore, using the STINGa currently being tested in clinical trials, we screened for immunomodulatory agents that could synergize with the STING pathway to induce a systemic antitumor immune response and regression of distant tumors. We combined the STINGa with agents that improve APC or T-cell function. We found that modulation of both APCs and T cells can enhance control of distant lymphoma tumors by STINGa. In particular, adding an anti-GITR antibody induced lymphocyte expansion in the lymph node draining the treated site followed by increased T-cell infiltration in the distant tumor. Furthermore, more of these CD8 T cells at the distant site expressed PD-1. Therefore, blockade of PD-1 further enhanced tumor control at the distant site, leading to cure in 50% of the mice. These preclinical data provide the rationale for testing local injection of STINGa followed by agonistic anti-GITR and anti-PD-1 antibodies as immunotherapy for human lymphoma.
Optimizing the use of trimethoprim-sulfamethoxazole for prevention of PCP and opportunistic infections in allogeneic hematopoietic cell transplant recipients.

138Background: Trimethoprim-sulfamethoxazole (TMP-SMX) is preferred for prevention of Pneumocystis pneumonia (PCP), toxoplasmosis and other opportunistic infections after allogeneic hematopoietic c...
Mathematical Analysis of the Jin-Neelin Model of El Niño-Southern-Oscillation

The Jin-Neelin model for the El Nino–Southern Oscillation (ENSO for short) is considered for which the authors establish existence and uniqueness of global solutions in time over an unbounded channel domain. The result is proved for initial data and forcing that are sufficiently small. The smallness conditions involve in particular key physical parameters of the model such as those that control the travel time of the equatorial waves and the strength of feedback due to vertical-shear currents and upwelling; central mechanisms in ENSO dynamics. From the mathematical view point, the system appears as the coupling of a linear shallow water system and a nonlinear heat equation. Because of the very different nature of the two components of the system, the authors find it convenient to prove the existence of solution by semi-discretization in time and utilization of a fractional step scheme. The main idea consists of handling the coupling between the oceanic and temperature components by dividing the time interval into small sub-intervals of length k and on each sub-interval to solve successively the oceanic component, using the temperature T calculated on the previous sub-interval, to then solve the sea-surface temperature (SST for short) equation on the current sub-interval. The passage to the limit as k tends to zero is ensured via a priori estimates derived under the aforementioned smallness conditions.
Operators on Graphs

This chapter gives a brief introduction to the spectral theory of graphs. The primary focus is on quantum graphs consisting of the Laplacian operator acting on a metric graph.
New integrable (2+1)-dimensional sine-Gordon equations with constant and time-dependent coefficients: Multiple optical kink wave solutions

Abstract This work studies new integrable (2+1)-dimensional sine-Gordon equations, the first is characterized with constant coefficients, while the other is defined with time-dependent coefficients. We show that the first equation passes the Painleve test for complete integrability. We also study the compatibility conditions that ensure the integrability of the second model with time-dependent coefficients. We show that the dispersion relations of the two equations are distinct, whereas the phase shifts are identical. We apply the simplified Hirota's method where multiple optical kink wave solutions will be reported for each equation.
A phase Ib study of endogenous SLC45A2-specific cytotoxic T cells for the treatment of patients with metastatic uveal melanoma.

TPS10086Background: Overall survival (OS) for patients (pts) with advanced uveal melanoma (UM) is poor with a median survival of approximately 12 months. Roughly half of all pts with UM will develo...
Counter incision is a safe and effective method for alternative reservoir placement during inflatable penile prosthesis surgery.

Background Alternative reservoir placement is increasingly popular during inflatable penile prosthesis (IPP) surgery to prevent intraperitoneal positioning, bowel, bladder, or vascular injury in patients with prior pelvic surgeries. Counter incision (CI) can be used for submuscular reservoir placement in high risk patients, however series exploring the safety remain limited. Methods A database of IPP surgeries was queried for use of a CI during reservoir placement to compare 90-day clinical outcomes in a retrospective case-control study. Primary outcome was device infections, with secondary outcomes including reservoir herniation, hematoma, device malfunction rates, and operative times. Groups were compared using Kruskal-Wallis and Chi-Squared tests, with multivariate logistic regression models to identify predictors of infectious complications. Results A total of 534 cases met criteria, of which 51 (9.6%) used a CI for reservoir placement. The CI cohort included significantly more removal and replacements, 45.1% vs. 20.9% (P<0.001). Thirty-one CI patients (61.0%) had undergone prior prostatectomy compared to 134 (27.7%) non-CI patients (P=0.001). The most common reasons for CI were prior prostatectomy and inguinal hernia repair. Median operative time was 17 minutes longer in the CI group (74 vs. 57 minutes, P<0.001). Device infection rates were similar (2.0% vs. 4.1%, P=0.71), as were rates of hematoma (5.9% vs. 2.7%, P=0.19), and device malfunction (0.0% vs. 1.4% P=1.00). Conclusions Complication rates were similar between CI and non-CI cohorts, even in a subset where approximately half the cases were removal and replacements. For physicians not comfortable with alternative placement through a penoscrotal or infrapubic incision, this offers a reasonable alternative and permits use of three-piece devices in patients with a hostile pelvis.
Evaluation of the distance between the root apices of the upper first molars and the hard palate in an Eastern Mediterranean population: A retrospective study

Summary Objective The aims of this retrospective study were, first to evaluate the distance between the root apices of the upper first molars and the palatal plane (PP), and second to determine the validity (accuracy) of the use of cephalometric radiographs or panoramic X-rays compared to cone beam computed tomography (CBCT) in determining this distance. Material and methods The distance was calculated from the root apices of the first molars to PP, on the cephalometric radiographs of 204 subjects and then 57 measurements were compared to those obtained on panoramic X-rays and CBCT images, in order to find a statistically significant difference according to age, sex, side, vertical and sagittal skeletal patterns, and to determine if 2D radiographs are suitable for this task. Results The distance increased significantly in subjects after 20 years of age and in hyperdivergent patients, but was not influenced by sex, side or anteroposterior position of the mandible. No statistical significance was found between the calculated measurements on cephalometric and CBCT radiographs, but both were different from those taken on panoramic X-rays. Conclusions Cephalometric radiographs are reliable in the assessment of the distance between the roots of the upper molars and the PP. In hyperdivergent and adult patients, posterior teeth have enough space between their roots and the upper limit of the hard palate to undergo intrusion mechanics using miniscrews, but care must be taken while planning and managing these movements in order to minimize the unwanted side effects.
MPN-383: GLI1 Promotes the Pro-Fibrotic Function of Monocyte-Derived Fibrocytes in Myelofibrosis

Primary myelofibrosis (MF), post-polycythemia vera (PV) MF, and post-essential thrombocytosis MF are myeloproliferative neoplasms (MPNs) characterized by progressive bone marrow (BM) fibrosis. A recent study suggested that glioma-associated oncogene-1 (GLI1), a downstream effector of the embryonic Hedgehog pathway, is implicated in the pathogenesis of BM fibrosis in MF. Because we and other investigators have found that monocyte-derived fibrocytes, rather than mesenchymal stromal cells (MSCs), induce BM fibrosis in MF, we sought to determine the role of GLI1 in MF fibrocytes. To do this, we analyzed BM biopsy sections of patients with MF using multiplex fluorescence immunohistochemistry and detected high levels of GLI1 in CD45+/CD68+/procollagen I+ fibrocytes and low levels of GLI1 in CD90+/CD105+ MSCs (P=0.009 and P=0.002, respectively). Using immunostaining, RNA in situ hybridization, gene expression, and western immunoblotting analyses of cultured BM fibrocytes or MSCs, we observed significantly higher levels of GLI1 and GLI1-induced matrix metalloproteases (MMP) 2 and 9 in MF fibrocytes than in MF MSCs or normal BM-derived fibrocytes (P
Anisotropic Nested Hollow-core Fiber Designs

A new type of anisotropic nested hollow-core anti-resonant fiber is proposed which has propagation loss of <0.11 dB/km with wide-band transmission window, and truly single-mode behavior that have all favorable properties for future optical communication. © 2021 The Author(s)
Non-Traumatic Spontaneous Spinal Subdural Hematoma in a Patient with Non-Valvular Atrial Fibrillation During Treatment with Rivaroxaban

Background Spontaneous spinal subdural hematoma (SSDH) is a rare but disabling condition, accounting for only 4.1% of all intraspinal hematomas. Risk factors include arteriovenous malformations, coagulopathy, therapeutic anticoagulation, underlying neoplasms, or following spinal puncture. Vitamin K antagonists, antiplatelet agents, and heparinoids have been associated with SSDHs in prior reports. To the best of our knowledge, no cases have reported this association with the factor Xa inhibitor, rivaroxaban, and SSDHs. Case report We report the case of a 69-year-old Honduran man with a 5-year history of symptomatic palpitations due to non-valvular atrial fibrillation. He was initially refractory to pharmacologic therapy. He underwent cardioversion in February 2014. After cardioversion, he remained asymptomatic on flecainide. He was anticoagulated on rivaroxaban 20 mg daily without incident since early 2013 until presentation in August 2014. He presented with sudden onset of excruciating upper and lower back pain after minimal movement. This was immediately followed by bilateral lower extremity paresis rapidly progressing to paraplegia with bowel and bladder dysfunction over 15 minutes. Magnetic resonance imaging demonstrated an acute spinal subdural hematoma extending from T3 inferiorly to the conus medullaris. Six months after undergoing cervical and lumbar drainage procedures, he has not recovered bowel, bladder, or lower extremity neurologic function. Conclusions Non-traumatic spontaneous spinal subdural hematoma is a rare neurological emergency that may occur during the use of rivaroxaban in patients with non-valvular atrial fibrillation. Physicians should suspect SSDH in patients on rivaroxaban with acute onset of severe back pain and neurologic symptoms to improve the odds of a favorable outcome.
Involutive property of resolutions of differential operators

Let E and E′ be C ∞ vector bundles over a C ∞ manifold M. Denote by Γ(E) (resp. by Γ(E′) the vector space of C ∞ cross-sections of E (resp. of E′) over M. Take a linear differential operator of the first order D: Γ(E) → Γ(E′) induced by a vector bundle mapping σ(D): jl (E) ′ E′, where Jk (E) denotes the vector bundle of k-jets of cross-sections of E.
NAMD: A Case Study in Multilingual Parallel Programming

Parallel languages are tools for constructing efficient application programs, while reducing the required labor. In this light, using the most appropriate tool for each component of a complex system seems natural, resulting in multi-paradigm multilingual programming. The Converse system developed at Illinois addresses the issues involved in supporting multilingual applications. This paper describes the development of a large parallel application in Computational Biophysics from the point of view of multilingual programming. NAMD, a molecular dynamics program, is implemented using three different “paradigms”: Parallel message-driven objects, Message-Passing, and Multithreading. The issues faced in implementing such a system, and the advantages of multilingual approach are discussed. NAMD is already operational on many parallel machines. Some preliminary performance results are presented and the lessons learned from this experience are discussed.
Theory of earthquakes

The scale independent inclusion theory of rock failure developed in Part I is applied to the problem of crustal earthquakes and, in particular, to the problem of premonitory phenomena reported to precede such earthquakes. Several well-known premonitory effects such as anomalous variation in the ratio of longitudinal (V p ) and shear (V s ) seismic velocities, V P /V S , tilt, regional and local crustal movements and stress axis rotation, to mention a few, are shown to be a natural consequence of the physical processes leading to failure in dry rock. The effects of fluids on failure in the focal region of a potential earthquake are considered in terms of the scale independent inclusion theory.
Stratigraphy and Taphonomy of Grizzly Buttes, Bridger Formation, and the Middle Eocene of Wyoming

For over a century the Bridger Formation of southwestern Wyoming has yielded fossils of many important middle Eocene vertebrate taxa. This formation is of particular interest to the study of ancient primates because their remains are plentiful. In fact, the first fossil primates described from the Western Hemisphere, Omomys carteri and Notharctus tenebrosus were found here (Leidy, 1869, Leidy, 1870). Arguably, the premier fossil collecting locale within the Green River Basin is an area known as Grizzly Buttes (Figure 1). Although the place name has disappeared from official maps and the local lexicon (West, 1990), it is well established in the paleontological literature. The area has a rich history. Both O. C. Marsh and E. D. Cope collected from these outcrops in the 1870′s extending their professional rivalry to the description of Bridgerian mammals (Wheeler, 1961). The area is figured by H. F. Osborn (1910) as the “famous” locality of Grizzly Buttes.
Implementation without commitment in moral hazard environments

I define a solution concept for strategic form games called interdependent-choice equilibrium. It is an extension of correlated equi- librium, in which the mediator is able to choose the timing of his signals and observe the actions taken by the players. The set of interdependent- choice equilibria is nonempty and is given by a finite set of affine inequal- ities. It characterizes all the outcomes that can be implemented in single shot interactions without the use of binding contracts or any other form of delegation. The results can also be interpreted as robust predictions for environments in which the rules of the game (e.g. order of play and information structure) are unknown.
Perspective on metal-mediated polar monomer/alkene copolymerization

Abstract A major unsolved problem in polymer synthesis is the design of efficient metal-mediated systems for the copolymerization of alkenes with polar vinyl monomers, such as acrylates and methacrylates. There are several reasons for the absence of efficient transition metal-based insertion copolymerization catalysts. First, following insertion, the ester group of the acrylate coordinates to the metal thereby hindering subsequent monomer coordination. A second reason stems from the preferred 2,1-insertion of acrylates into metal–carbon bonds resulting in the placement of the ester group on the α-carbon. This makes the metal–alkyl species particularly prone to homolysis because of the enhanced stability of the resultant alkyl radical, one that is essentially the same as the propagating species in radical-initiated acrylate polymerization. In this perspective we focus on this issue of facile metal–carbon bond homolysis, especially following acrylate insertion, using examples from our own work. We suggest ways to circumvent these issues, for example forcing 1,2-insertion by imposing steric crowding at the metal. Finally, we discuss the danger of relying on radical traps as probes for polymerization mechanism. Radical traps can react with metal-hydrides and attenuate metal-centered nonradical reactions. However, even when radical traps fail to stop an observed polymerization, it may be wrong to conclude that a nonradical mechanism is at work since the traps can be destroyed under certain reaction conditions.
Recurrent Nested Stromal Epithelial Tumor of the Liver with Extrahepatic Metastasis: Case Report and Review of Literature

Nested stromal epithelial tumor is a recently described primary neoplasm of the liver. This tumor is characterized by well-demarcated nests of spindle and epithelioid cells with occasional calcification and bone formation. An association between these tumors and Cushing syndrome has been described. Herein we report a case of a recurrent nested stromal epithelial tumor of the liver in a 17-year-old female with aggressive clinical behavior and an extrahepatic lymph node metastasis. Also, we provide the first detailed clinical, histologic, immunohistochemical, and cytogenetic comparison of the original and recurrent tumors. Initially, the patient presented with Cushingoid symptoms and epigastric pain, radiating to her back. A computed tomographic (CT) scan revealed a large lesion in the liver. After a partial hepatectomy, the Cushingoid features were resolved. A year later, a CT scan revealed multiple lesions within the liver, and positron emission tomographic/CT imaging showed a hypermetabolic lymph node. The patient underwent a cadaveric liver transplant. Histologically, both the original and recurrent tumors had similar characteristics, with different immunoreactivity, correlating with the absence of systemic hormonal symptoms. Electron microscopy of the original neoplasm revealed an abundance of rough cytoplasmic reticulum and mitochondria. No evidence of endocrine differentiation was found. Cytogenetics of the primary tumor was complex with an abnormal hypotriploid karyotype. Our data indicate that patients with nested stromal epithelial tumor of the liver must be carefully followed with imaging to detect hepatic recurrence and extrahepatic metastases.
Solid state coordination chemistry of oxovanadium phosphates: hydrothermal syntheses and structures of the network and chain phosphate phases [{Cu(bpy)}2(VO)3(PO4)2(HPO4)2]·2H2O and [{Cu(terpy)}2(VO2)3(PO4)(HPO4)2]

The hydrothermal reactions of Cu2O, the appropriate polypyridine ligand, Na3VO4, H3PO4 and H2O at 200 °C yield the two-dimensional material [{Cu(bpy)}2(VO)3- (PO4)2(HPO4)2]·2H2 O and the one-dimensional phosphate [{Cu(terpy)}2(VO2)3(PO4 )(HPO4)2], examples of the structure-directing role of secondary metal–ligand subunits on the architectures of vanadium phosphates.
Local Support for Alcohol Control Policies and Perceptions of Neighborhood Issues in Two College Communities.

ABSTRACTBackground: Although valuable, national opinion surveys on alcohol policy may be less informative for policy development at the local level. Using samples of adult residents in 2 college communities, the present study: (1) measured public support for local alcohol control policies to stem underage drinking and alcohol overservice in on-premise outlets, (2) assessed residents’ opinions regarding neighborhood problems, and (3) identified factors associated with strong policy support. Methods: We administered random-sample telephone surveys to residents aged 21 years and older in college communities located in Community 1 (N = 501; mean age = 57.4 years, SD = 14.7) and Community 2 (N = 505; mean age = 56.0 years, SD = 15.2). The response rates were typical of telephone surveys (Community 1: 33.5%; Community 2: 29.9%). We assessed support for 16 alcohol control policies and the occurrence of specific types of neighborhood incidents (e.g., witnessing intoxicated people). We used multiple regression ana...