cssi/SciSciGPT-SciSciNet huggingface dataset:
[3H]prostaglandin F2α membrane binding reexamined

Tritiated prostaglandin F2 alpha ([3H]PGF2 alpha) binding to bovine corpora luteal membranes has been reexamined from the viewpoint of eventual PGF2 alpha receptor purification. Several modifications of the literature on PGF2 alpha binding allow for a more stabilized [3H]PGF2 alpha PGF2 alpha receptor complex which should then facilitate the PGF2 alpha receptor purification. Of particular importance were: identification of protease inhibitors which protect [3H]PGF2 alpha binding and protease inhibitors which are detrimental to subsequent [3H]PGF2 alpha binding; the finding that EGTA treatment of tissue homogenates greatly protects subsequent [3H]PGF2 alpha binding; the observation that Mn(+)+ substitutes for Ca(+)+ and, in fact, among the divalent cations Mn(+)+ greater than Mg(+)+ greater than Ca(+)+ in facilitating [3H]PGF2 alpha binding where as Cd(+)+, Cu(+)+ and Zn(+)+ either have no effect or are detrimental to this binding; the lack of effect of ATP, GTP, GDP and cAMP or of kinase and phosphatase inhibitors and activators to alter binding of [3H]PGF2 alpha to isolated membranes; and the ease with which the [3H]PGF2 alpha-PGF2 alpha receptor complex can be removed from the membrane in spite of the receptor being an integral membrane protein. A new simple technique for separating protein bound [3H]PGF2 alpha (PGF2 alpha receptor-[3H]PGF2 alpha complexes) from free [3H]PGF2 alpha by use of hydroxyapatite (HAP) is introduced. This HAP method is of particular use in solubilized membrane preparations (but can also be used during PG radioimmunoassays to separate free PG from antibody bound PG). These changes were required to facilitate subsequent chromatographic steps leading to identification and purification of the PGF2 alpha receptor. (ABSTRACT TRUNCATED AT 250 WORDS)
Anaerobic microbial activities including hydrogen mediated acetogenesis within natural gas transmission lines

Microbially influenced corrosion (MIC) is being increasingly recognised as a serious problem. To investigate the role of MIC, radiotracer activity and lipid biomass measurements were performed on samples from offshore and on‐shore natural gas transmission systems. These measurements evaluated the biomass and metabolism of microbial communities residing inside transmission pipelines. Aqueous and nonaqueous hydrocarbon samples from liquid separators, sludge catchers and nodules attached to pipe walls were aseptically recovered and inoculated into anaerobic tubes for radiotracer time course experiments or preserved with chloroform‐methanol for total lipid analyses. MPN enrichments and phospholipid biomass determinations estimated microbial populations of 104—107 cells per gram in several samples. General microbial metabolism was demonstrated by [l‐14C]acetate incorporation into lipids and by [14C]CO2 production from [U‐14C]glucose. [14C]Acetate was slowly mineralised to 14CO2 without significant methane prod...
Effect of fenoldopam prodrug, SK&F R‐105058, on renal function in rats

Recent development of and studies on fenoldopam prodrugs have shown their prolonged hemodynamic effects. This study was carried out in order to examine the effect of a fenoldopam prodrug on renal function in rats. In the present study we administered SK&F R-105058, the 4′,7,8-tris-N-ethyl carbamate ester of R-fenoldopam, at a dose of 30 μg/kg/min intravenously to the anesthetized rats. This prodrug produced long-lasting increases in water and sodium excretion after termination of the 30-min drug infusion with minimum changes in hemodynamic parameters. The diuresis and natriuresis were attenuated in the presence of a selective DA1 receptor antagonist SCH 23390. Therefore, it is suggested that production of fenoldopam from its precursor drug SK&F R-105058 caused these prolonged renal effects, which were mediated via the activation of DA1 receptors located on renal tubules. © 1992 Wiley-Liss, Inc.
Comparison of verbal memory impairment rates in mild cognitive impairment

There are no accepted guidelines establishing the most sensitive neuropsychological methods to define memory impairment in mild cognitive impairment (MCI). We investigated whether similar impairment rates were observed between the Hopkins Verbal Learning Test-Revised (HVLT-R) and Logical Memory (LM) in 90 patients with amnestic or amnestic plus MCI. On HVLT-R delayed recall, 80% of participants performed in the MCI range compared to only 32.2% on LM II. The same pattern was seen for both amnestic and amnestic plus subtypes. Individuals impaired on HVLT-R delayed recall performed significantly worse on LM first recall and on delayed recall of LM Story A than those not impaired. MCI patients with executive dysfunction performed significantly worse than patients with no executive impairment on both LM I and HVLT-R Total Learning, but not for delayed recall of either measure. Future studies can address the longitudinal course of impairment on these measures.
An SVM-based approach for genotyping deletions and insertions with population sequence reads

Because of the low quality and large size of population sequence data, calling population structural variations (SVs) genotypes is still a challenging problem. In this paper, we propose an SVM-based approach for genotyping deletion and insertion polymorphisms with population sequence reads. The key idea of our approach is combining multiple sources of information contained in sequence data in calling genotypes. Results on both simulated and real data suggest that our approach works well.
A parallel architecture for meaning comparison

In this paper we present a fine grained parallel architecture that performs meaning comparison using vector cosine similarity (dot product). Meaning comparison assigns a similarity value to two objects (e.g. text documents) based on how similar their meanings (represented as two vectors) are to each other. The novelty of our design is the fine grained parallelism which is not exploited in available hardware based dot product processor designs and can not be achieved in traditional server class processors like the Intel Xeon. We compare the performance of our design against that of available hardware based dot product processors as well a server class processor using optimum software code performing the same computation. We show that our hardware design can achieve a speedup of 62,000 times compared to an available hardware design and a speedup of 8866 times with 33% (1.5 times) less power consumption, compared to software code running on Intel Xeon processor for 1024 basis vectors. Our design can significantly reduce the amount of servers required for similarity comparison in a distributed search engine. Thus it can enable reduction in energy consumption, investment, operational costs and floor area in search engine data centers. This design can also be deployed for other applications which require fast dot product computation.
Age at onset of Parkinson disease and apolipoprotein E genotypes.

Several lines of evidence suggest that the variable age at onset of Parkinson disease (PD) is likely influenced by genes. The apolipoprotein E (APOE) gene is associated with onset of Alzheimer disease, and possibly other neurodegenerative disorders. APOE has been investigated in relation to onset of PD, but results have been inconsistent. The aim of the present study was to determine if APOE genotypes are associated with onset age of PD, using a patient population large enough to assure sufficient power. We studied 521 unrelated Caucasian patients with idiopathic PD from movement disorder clinics in Oregon and Washington. Genotyping and statistical analyses were carried out using standard methods. Age at onset of PD was significantly earlier in patients with the varepsilon3varepsilon4/varepsilon4varepsilon4 genotype than in patients with the varepsilon3varepsilon3 genotype (56.1 +/- 10.9 vs. 59.6 +/- 11.0, P = 0.003). The significantly earlier onset of PD was not influenced by the possible effects of recruitment site, family history and gender. The effect of the varepsilon2varepsilon3 genotype on onset of PD differed between the two recruitment sites. There was a trend for earlier onset of PD in varepsilon2varepsilon3 patients than in varepsilon3varepsilon3 patients only in the Oregon sample. In conclusion, APOE is associated with age at onset of PD.
Vegan diets and hypothyroidism

Diets eliminating animal products have rarely been associated with hypothyroidism but may protect against autoimmune disease. Thus, we investigated whether risk of hypothyroidism was associated with vegetarian compared to omnivorous dietary patterns. The Adventist Health Study-2 was conducted among church members in North America who provided data in a self-administered questionnaire. Hypothyroidism was queried at baseline in 2002 and at follow-up to 2008. Diet was examined as a determinant of prevalent (n = 4237 of 65,981 [6.4%]) and incident cases (1184 of 41,212 [2.9%]) in multivariate logistic regression models, controlled for demographics and salt use. In the prevalence study, in addition to demographic characterstics, overweight and obesity increased the odds (OR 1.32, 95% CI: 1.22–1.42 and 1.78, 95% CI: 1.64–1.93, respectively). Vegan versus omnivorous diets tended to be associated with reduced risk (OR 0.89, 95% CI: 0.78–1.01, not statistically significant) while a lacto-ovo diet was associated with increased risk (OR 1.09, 95% CI: 1.01–1.18). In the incidence study, female gender, white ethnicity, higher education and BMI were predictors of hypothyroidism. Following a vegan diet tended to be protective (OR 0.78, 95% CI: 0.59–1.03, not statistically significant). In conclusion, a vegan diet tended to be associated with lower, not higher, risk of hypothyroid disease.
Duodenal web associated with malrotation and review of literature

Intestinal obstruction due to midgut malrotation in neonates is well known. The incidence of malrotation in newborns is around 1:500 and the symptomatic incidence is 1:6000 births. Duodenal web as a cause of intestinal obstruction is less common and is reported to be 1:10 000–1:40 000. Malrotation is known to be associated with other congenital obstructive anomalies including duodenal atresia, stenosis and duodenal web. But, intestinal obstruction due to malrotation associated with duodenal web has been reported only rarely with a few published cases in our literature review. We present a case of intestinal obstruction diagnosed in the prenatal period via sonogram. A plain X-ray of the abdomen after birth showed a distended duodenum with paucity of air distally suggesting duodenal obstruction. An exploratory laparotomy showed a duodenal web proximal to the sphincter of oddi. The patient also had an associated malrotation and underwent Ladd's procedure and appendectomy. The post-operative period was uneventful.
Ethnic differences in the nutrient intake adequacy of premenopausal US women: Results from the Third National Health Examination Survey

Abstract Objective To examine the adequacy of dietary intake of calcium; folate; and vitamins C, D, E, B-6, and B-12 in premenopausal US women of differing ethnicity. Design Analyses of single and duplicate 24-hour recalls were conducted to determine dietary intake during the Third National Health and Nutrition Examination Survey. Subjects Three thousand five hundred eighty-five randomly selected women aged 20 to 50 years from across the United States who were not pregnant or lactating were examined between 1988 and 1994. Statistical analyses Usual nutrient intake distributions were estimated using the Iowa State University method for adjustment of the distribution. The Estimated Average Requirement cut-point method was used to determine the proportion of women with inadequate intake for each nutrient in each ethnic group. Results More than 75% of women irrespective of ethnic group had usual intakes of calcium lower than the new Adequate Intake. More than 90% of the women had inadequate intakes of folate and vitamin E from food sources alone. More than half of smokers had inadequate intakes of vitamin C. Intakes of vitamins B-6 and B-12 were low in less than 10% of these women. Applications/Conclusions This article provides evidence that a high proportion of premenopausal US women are underconsuming a variety of nutrients. Dietary intakes alone are not currently adequate to meet the new recommended intakes. Nutritional supplement use is widespread and effective, but does not eliminate the concerns for at-risk populations. Awareness of the general inadequacies in intakes of vitamin E and folic acid at large, and in many women vitamin C as well, can help direct individual dietary recommendations and place the emphasis in group counseling on nutrients that are of widespread concern. In addition, foods rich in vitamins B-6 and of general nutritional benefit should be emphasized among African American women in the United States as a substantial proportion of this group is still showing inadequate intakes from foods. J Am Diet Assoc. 2003;103:1008-1014.
Moral reasoning strategies of orthopaedic surgery residents.

Background Little is known about the moral reasoning utilized by orthopaedic surgery residents when resolving moral dilemmas. Methods Sixty-three residents in an accredited program took the Defining Issues Test-2, an online examination designed to measure and analyze moral reasoning. Scores approximate how often residents utilize three schemas in their moral reasoning: personal interest, maintaining social norms, and postconventional. Scores were analyzed for differences among years of training, previous literature, and established norms. Results Approximately 9.5% of residents utilized personal interest heavily in their moral reasoning, 27% utilized maintaining norms, and 63.5% utilized postconventional reasoning. There were no significant differences between years of training. The fourth-year (R4) class recorded the highest utilization of principled reasoning, while the fifth-year (R5) class recorded the lowest. The range of principled reasoning scores narrowed from the first year (R1) to R5. The principled reasoning scores of residents were significantly lower than previously reported scores of professional degree-holders and medical students, and empirically lower than previously reported scores of orthopaedic attendings and medical students. Conclusions Residents utilized principled reasoning less frequently than expected for physicians. It remains unclear as to what factors contributed to high utilization of principled reasoning in the R4 class but low utilization in the R5 class. Our cross-sectional data suggest that each year of training homogenizes toward a class-specific utilization of principled reasoning. It remains unclear why residents utilized principled reasoning less than orthopaedic attendings, medical students, and other professional degree-holders.
Thyroid Transcription Factor 1 Is an Independent Prognostic Factor for Patients With Stage I Lung Adenocarcinoma

Purpose Thyroid transcription factor 1 (TTF1) is a transcription factor that regulates the expression of multiple genes involved in lung development. It is preferentially expressed in adenocarcinomas of the lung and has been investigated as a potential prognostic parameter in patients with lung cancer, with conflicting results. We quantitatively assessed TTF1 protein expression in two large and independent data sets to investigate the impact of TTF1 nuclear expression on patient survival. Patients and Methods Automated quantitative analysis, a fluorescent-based method for analysis of in situ protein expression, was used to assess a series of cell lines to find the threshold of detection of TTF1 expression. Then two independent cohorts (176 and 237 cases, respectively) were measured by the same technique, and TTF1 expression was correlated with survival. Results Tumors expressed TTF1 in 45% and 58% of the cases in each cohort. TTF1 was consistently expressed in adenocarcinomas (n 61 and 73; Spearman 0.313 and 0.4 for the first and second set, respectively; P .0001) independent of their differentiation and stage. Survival analysis showed that patients with stage I adenocarcinoma with TTF1 expression had a longer median overall survival than those without expression (n 43, 44.3 v 26.2 months, P .05 for the first cohort; n 87; 49.7 v 38.5 months, P .03 for the second cohort) Multivariate analysis revealed an independent lower risk of death for patients with stage I adenocarcinoma with TTF1-expressing tumors (hazard ratio 0.479, 95% CI, 0.235 to 0.977; P .043). Conclusion TTF1 expression defines a subgroup of patients with a favorable outcome and may be useful for prognostic stratification of patients with stage I lung adenocarcinoma. J Clin Oncol 27:271-278. © 2008 by American Society of Clinical Oncology
Outcome of respiratory syncytial virus infection and a cost–benefit analysis of prophylaxis

Objectives: To determine outcome and length of stay (LOS) for infants younger than 2 years of age admitted to hospital for respiratory syncytial virus (RSV) infection and to perform a cost–benefit analysis of prophylaxis with RSV γ-globulin (Respigam; CSL Laboratories, Melbourne, Victoria, Australia) and monoclonal antibody (Synagis; Abbott Australasia, Kurnell, NSW, Australia) in the Australian context. Methods: Retrospective outcome study using data from an Australian hospital and intensive care databases over a 30 month period encompassing three RSV seasons (1 May 1997–31 October 1999). Results: The mortality for RSV infection was very low, being 0.29% of all patients admitted to hospital and 0% in infants without co-existing disease. Only 11.4% of infants required admission to the intensive care unit (ICU). Respiratory syncytial virus infection was not associated with prolonged hospitalization; patients managed in the general wards had a mean length of stay (LOS) of 4.13 days with a median of 3.0 days, while those requiring intensive care had a mean LOS of 9.8 days (including 5.1 days in the ICU). Use of RSV prophylaxis would be expected to reduce the requirement for hospital admission; however, the cost of prophylaxis is conservatively estimated to be between 7.2- and 65.3-fold the money saved in hospital care, depending on the weight of the patient and choice of drug. Conclusions: Respiratory syncytial virus is a major cause of morbidity, but not mortality, in infants. In infants requiring hospitalization for this disease, the LOS is relatively short and the mortality extremely low. Use of prophylactic agents, which reduce the probability of hospital admission but have no effect on mortality, cannot be justified in the Australian context on cost–benefit grounds.
Revealing representational content with pattern-information fMRI—an introductory guide

Functional Magnetic Resonance Imaging Facility, National Institute of Mental Health, National Institutesof Health, Bethesda, MD, USAConventional statistical analysis methods for functional magnetic resonance imaging (fMRI) data are very successful at detectingbrain regions that are activated as a whole during specific mental activities. The overall activation of a region is usually takento indicate involvement of the region in the task. However, such activation analysis does not consider the multivoxel patternsof activity within a brain region. These patterns of activity, which are thought to reflect neuronal population codes, can beinvestigated by pattern-information analysis. In this framework, a region’s multivariate pattern information is taken to indicaterepresentational content. This tutorial introduction motivates pattern-information analysis, explains its underlying assumptions,introduces the most widespread methods in an intuitive way, and outlines the basic sequence of analysis steps.
Two-Dimensional Autonomous Microparticle Manipulation Strategies for Magnetic Microrobots in Fluidic Environments

This study develops autonomous manipulation strategies for a mobile untethered microrobot that operates on a 2-D surface in a fluidic environment. The microrobot, which is a permanent magnet, is under m in all dimensions and is actuated by oscillating external magnetic fields. Two types of manipulations are considered: 1) front pushing, where the microrobot pushes a micro-object by direct contact; and 2) side pushing, which can result in noncontact pushing, where the fluid flow fields that are generated by a translating microrobot are used to displace a micro-object. Physical models are provided to estimate the displacement of the micro-object due to the fluid motion. Model-based controllers to perform contact and noncontact manipulation are proposed, which iteratively correct emerging manipulation behaviors to improve performance. It is found that using a model-based solution as a feed-forward input, which is combined with a learning controller, can significantly improve micro-object pushing performance. Finally, we begin to address the problem to assemble two micro-objects together using the microrobot, which is only successful by using a side-pushing method.
Robust UAV Coordination Under Variable Communication Rates

This work considers autonomous coordinated maneuvering to accommodate tracking of a moving target with multiple UAVs. The maneuvering logic is implemented with guidance algorithms that consequently rely on communication between vehicles. Of concern is the robustness of the guidance laws with respect to variable input/output communication rates and data drop outs. To recover robustness, this work compares two observers to estimate location of remote UAVs during communication loss/silence. The flrst observer is derived as an analytic model. The second observer is based on a kinematic aircraft model that captures vehicle dynamics and limits. Results are demonstrated using hardware-quality ∞ight simulators running on a distributed network providing real time simulation.
Robinson* line-heat-source guarded hot plate apparatus

This paper presents a description of the line-heat-source guarded hot plate apparatus conceived by the late H. E. Robinson, the results of mathematical analyses of potential sources of uncertainty, and the design of an apparatus of this type being constructed at the National Bureau of Standards. This design utilizes a line source heater, from which heat diffuses laterally in the plate. Such a design does not produce a wholly uniform plate temperature, but does enable calculation of average plate surface, and edge, temperatures utilizing only a few temperature sensors.
Outcomes from an outpatient smoking-cessation clinic.

Study Objectives. To determine the success of an outpatient smoking-cessation clinic by assessing smoking abstinence rates and factors associated with lower abstinence rates. We also sought to determine whether smoking abstinence rates differed among various smoking-cessation products. Methods. Patients were referred by primary care providers to a pharmacist-managed smoking-cessation clinic. Patients received tailored behavioral counseling, educational materials, and drug therapy consisting of sustained-release (SR) bupropion; nicotine patch, inhaler, or nasal spray; or combination therapy. Patients were monitored by phone or clinic visit for 6 months, if possible. Outcomes assessed were abstinence (both point prevalence and continuous abstinence) and adverse effects. Patients lost to follow-up were assumed to be smoking. Results. Over 2 years, 198 patients were enrolled in the program. At the initial visit, 35.4% received the patch, 32.8% bupropion SR, 18.2% a combination of patch plus inhaler, 9.6% inhaler alone, and fewer than 5% other therapies. At 6 weeks, a statistically significant difference was observed in continuous abstinence rates between the nicotine patch versus bupropion SR groups (22.9% vs 7.7%, p=0.02) and between the combination patch-inhaler versus bupropion SR groups (25% vs 7.7%, p=0.02). However, this difference was not significant beyond the 6-week visit. A trend toward higher abstinence rates was noted at 6 weeks in the nicotine patch–inhaler versus the other treatment groups, possibly suggesting the need for more intense treatment regimens with combination therapy. Point prevalence abstinence rates after 12 weeks were 18.6%, 15.4%, 22.2% and 21.1% respectively, for the patch, bupropion SR, patch-inhaler, and inhaler alone treatment groups. The corresponding continuous abstinence rates were 10.0%, 3.1%, 11.1%, and 10.5%. Conclusion. Although statistically significant differences between products were noted at 6 weeks, no sustained difference in smoking abstinence rates was observed between products. At 6 months, point prevalence and continuous abstinence rates were small, but the decline in success noted over time and the limited overall success rates are consistent with rates for the United States. Our findings suggest that when smokers are assisted in quitting, initial contact as well as follow-up evaluation and monitoring must be intense and sustained to increase the likelihood of successful abstinence. Tobacco dependence is clearly a chronic condition warranting repeated treatment and monitoring until continuous abstinence is achieved.
Kinetics of Drug-Drug Interactions

Open any current medical journal and one is reminded that the coadministration of two or more drugs can either cause deleterious effects or lead to ineffective therapy. Those concerned with drug therapy are increasingly aware of this phenomenon but are confronted with the problem that a patient may be taking three, four, and, on occasion, even more drugs simultaneously. The computer will aid in the storage and retrieval of such information and act as a useful early warning signal, but prudent multiple drug therapy, if deemed necessary, can only be achieved with a better understanding of the nature and quantitative aspects of drug interactions. A drug interaction might broadly be defined as any reaction between one drug and another substance within or out of the body. In this review, the definition is restricted to events occurring within living systems with major emphasis on the alteration by one drug on the rate and extent of absorption, distribution, metabolism, and excretion of another. Prescott (1969) has called these “pharmacokinetic interactions” to distinguish them from the numerous interactions between drugs at their sites of action (Morrelli, 1970). This distinction is somewhat arbitrary as any or all possibilities can occur in vivo. The interaction may be direct, such as the competitive inhibition of drug metabolism and the displacement of a drug from binding sites, or it may be indirect. One example of the latter is the decreased renal clearance of acids, whose renal clearance is sensitive to urinary pH, produced when the urine is rendered alkaline using either the carbonic anhydrase inhibitor, acetazolamide, or sodium bicarbonate.
Time Interval From a Brain Insult to the Onset of Infantile Spasms

The temporal latency between an encephalopathic event and the onset of infantile spasms cannot be determined in the majority of symptomatic cases (e.g. genetic conditions, cerebral malformations). However, we can measure this interval when a previously normal infant sustains brain injury followed by infantile spasms. This information has implications for understanding the underlying pathophysiologic basis for infantile spasms and, also, is germane to allegations that a close temporal relationship between vaccination and the onset of this seizure disorder establishes causation. We identified 19 published cases with sufficient information. The interval between brain injury and the onset of infantile spasms ranged from 6 weeks to 11 months (mean = 5.1 months). A similar temporal latency occurs in children with perinatal cerebral infarction and infantile spasms. We conclude that infantile spasms do not occur acutely following an encephalopathic event. This interval of weeks to months is consistent with prior studies indicating temporal latency between brain injury and the onset of other types of epilepsy, as well as with the previously proposed developmental desynchronization hypothesis. The findings refute claims that a close temporal association between an immunization and the onset of infantile spasms establishes causation.
Examination of the behavioral effects of oral cannabidiol alone and in combination with smoked marijuana

Aims: To examine correlates of interpersonal relationship dysfunction among Veterans with concurrent Post Traumatic Stress Disorder (PTSD) and Substance Use Disorder (SUD). Methods: Participants (n=112) were treatment-seeking VeteranswhometDSM-IV-TR criteria for current PTSD and SUD (average age=41.2 years old, 91%male, 60.7%Army). Clinician-administered and self-report surveyswere used to collect baseline data as part of a larger study: the Mini-International Neuropsychiatric Interview, Clinician-Administered PTSD Scale, Addiction Severity Index, Lite version, Dyadic Adjustment Scale, Interpersonal Support Evaluation List, and Deployment Risk and Resilience Inventory. Results: Over half (56.3%, n=63) of the sample experienced divorce or separation from a partner during post-deployment. Veterans who did vs. did not experience post-deployment divorce or separation reported significantly higher rates of lifetime physical abuse (45.2% vs. 19.1%, p= .005), lifetime sexual abuse (29.0% vs. 10.6%, p= .03) and being physically injured by another person (65.1% vs. 38.8%, p= .006). Rates of lifetime emotional abuse (43.5% vs. 30.6%, NS) and past-month suicidal ideationwere similar across groups (59.7% vs. 51.0%, NS). Veterans who did vs. did not experience post-deployment divorce or separation smoked significantly more cigarettes per day (p= .03), endorsed more years of alcohol intoxication (p= .04), and reported a greater number of hospitalizations for medical problems (p= .03). Conclusions: The findings reveal high rates of relationship dysfunction following deployment in PTSD/SUD Veterans. In addition, high rates of physical and sexual abuse, as well as increased substance use were associated with post-deployment relationship dysfunction. The findings provide useful clinical information and may help inform the development of effective treatment interventions for Veterans with PTSD and SUD. Financial support: NIDA R01 DA030143 (SEB).
[6,6'-Bis(1,1-di-methyl-eth-yl)-4,4'-dimethyl-2,2'-methyl-enediphenolato-κ(2) O,O']di-chlorido-(9H-fluoren-9-ol-κO)titanium(IV)-fluorene-diethyl ether (1/0.5/1).

The title adduct, [TiCl2(C23H30O2)(C13H10O]·0.5C13H10·C4H10O, is a monomer with a trigonal–bypyramidal coordination sphere of the TiIV atom in which the ligand O atoms of the bidentate diphenolate anion are located in both apical and equatorial positions. Chloride ligands occupy the remaining two equatorial sites of the trigonal bypyramid with the fluoren-9-ol O atom occupying the other apical site. The hy­droxy group H atom of this latter group is hydrogen bonded to an O atom of a non-coordinating diethyl ether mol­ecule. The title compound also contains a further fluorene solvent mol­ecule, which lies across a centre of symmetry and which is equally disordered over an inversion centre.
Meteorological factors contributing to the interannual variability of midsummer surface ozone in Colorado, Utah, and other western U.S. states

We use daily maximum 8 h average surface O3 concentrations (MDA8) for July 1995–2013, meteorological variables from the National Center for Environmental Prediction/National Center for Atmospheric Research Reanalysis, the North American Regional Reanalysis, and output from regional chemistry-climate simulations to assess relationships between O3 and weather in the western U.S. We also explore relationships among July O3, satellite-derived NO2, and meteorology. A primary objective of this study is to identify an effective method for correcting the effects of meteorology on July MDA8. We find significant correlations between July MDA8 O3 and meteorological variables for sites in or near Denver, Colorado, and Salt Lake City, Utah. The highest correlations were for 500 hPa heights, surface temperatures, and 700 hPa temperatures and zonal winds. We conclude that increased 500 hPa heights lead to high July O3 in much of the western U.S., particularly in areas of elevated terrain near urban sources of NO2 and other O3 precursors. In addition to bringing warmer temperatures and fewer clouds, upper level ridges decrease winds and allow cyclic terrain-driven circulations to reduce transport away from sources. Because of strong, nearly linear responses of July MDA8 to 500 hPa heights, it is not reasonable to use uncorrected trends in peak O3 for assessments of the effectiveness of emissions controls for much of the western U.S. Robust linear regressions for July MDA8 and tropospheric NO2 with 500 hPa heights can be used to assess and correct trends in July MDA8 in the Intermountain West.
Nanotopographical Modulation of Cell Function through Nuclear Deformation.

Although nanotopography has been shown to be a potent modulator of cell behavior, it is unclear how the nanotopographical cue, through focal adhesions, affects the nucleus, eventually influencing cell phenotype and function. Thus, current methods to apply nanotopography to regulate cell behavior are basically empirical. We, herein, engineered nanotopographies of various shapes (gratings and pillars) and dimensions (feature size, spacing and height), and thoroughly investigated cell spreading, focal adhesion organization and nuclear deformation of human primary fibroblasts as the model cell grown on the nanotopographies. We examined the correlation between nuclear deformation and cell functions such as cell proliferation, transfection and extracellular matrix protein type I collagen production. It was found that the nanoscale gratings and pillars could facilitate focal adhesion elongation by providing anchoring sites, and the nanogratings could orient focal adhesions and nuclei along the nanograting direct...
How Does the NFL Rate the Passing Ability of Quarterbacks

(1993). How Does the NFL Rate the Passing Ability of Quarterbacks? The College Mathematics Journal: Vol. 24, No. 5, pp. 451-453.
Electrochemical and Spectroscopic Evidence on the One-Electron Reduction of U(VI) to U(V) on Magnetite

Reduction of U(VI) to U(IV) on mineral surfaces is often considered a one-step two-electron process. However, stabilized U(V), with no evidence of U(IV), found in recent studies indicates U(VI) can undergo a one-electron reduction to U(V) without further progression to U(IV). We investigated reduction pathways of uranium by reducing U(VI) electrochemically on a magnetite electrode at pH 3.4. Cyclic voltammetry confirms the one-electron reduction of U(VI) to U(V). Formation of nanosize uranium precipitates on the magnetite surface at reducing potentials and dissolution of the solids at oxidizing potentials are observed by in situ electrochemical atomic force microscopy. XPS analysis of the magnetite electrodes polarized in uranium solutions at voltages from −0.1 to −0.9 V (E0U(VI)/U(V)= −0.135 V vs Ag/AgCl) show the presence of only U(V) and U(VI). The sample with the highest U(V)/U(VI) ratio was prepared at −0.7 V, where the longest average U–Oaxial distance of 2.05 ± 0.01 A was evident in the same sample...
Adjust Fire Goal with UAV based on Dynamic Bayesian Network

Dynamic Bayesian Networks are a powerful methodology for representing and computing with uncertain problem of stochastic processes.We combine Hidden Markov Models with Bayesian Network to rearch photo gained by UAV,and build a battlefield dynamic model base on Dynamic Bayesian Networks.In the end,we use a Viterbi algorithm to inference and get the best estimate about hidden sequence.The next step,we can use Fuzzy inference to get number of area that should shoot first.The model can provide correct and useful information for commander so that he can separate important things from general and decide how to use shellfire better.
Design of uPSD-Based Temperature and Pressure Compensations for Flux Controller

The method of the temperature and pressure compensations for flux measurement and the system of uPSD-Based controller were described.The characteristic and the configuring of uPSD3212c were introduced,and the program chart was given.uPSD has the characteri stics of integration and firmwaring.
Dynamic cell–matrix interactions modulate microbial biofilm and tissue 3D microenvironments

Microbial biofilms and most eukaryotic tissues consist of cells embedded in a three-dimensional extracellular matrix. This matrix serves as a scaffold for cell adhesion and a dynamic milieu that provides varying chemical and physical signals to the cells. Besides a vast array of specific molecular components, an extracellular matrix can provide locally heterogeneous microenvironments differing in porosity/diffusion, stiffness, pH, oxygen and metabolites or nutrient levels. Mechanisms of matrix formation, mechanosensing, matrix remodeling, and modulation of cell-cell or cell-matrix interactions and dispersal are being revealed. This perspective article aims to identify such concepts from the fields of biofilm or eukaryotic matrix biology relevant to the other field to help stimulate new questions, approaches, and insights.
County planners’ perceptions of land-use planning tools for environmental hazard mitigation: : A survey in the U.S. Pacific states

Land-use planning tools have been extensively applied in the U.S. to achieve environmental sustainability and disaster resiliency for local communities. An important issue related to land-use planning tools is planners’ beliefs about the ways in which these tools differ from each other and, thus, how planners choose among these tools for environmental hazard mitigation. A web-based survey collected data from planners in counties (or boroughs) in the five U.S. Pacific states (where county land-use planning is limited to unincorporated areas). The results indicate that planners substantially, but not completely, agreed in their perceptions of planning tools, that planners’ perceptions of planning tools are minimally related to their personal characteristics and those of their jurisdictions, and that planners’ perceptions of planning tools are significantly correlated with the capacity of their planning agencies. Planners viewed effectiveness (a desirable attribute) as positively correlated with economic costs and other impediments (which are undesirable attributes) so they must make trade-offs among these attributes and choose the most appropriate tool when formulating a growth management strategy.
Tibia Shaft Fractures of the Distal Third Treated with Plate Fixation of Tibia and Fibula

This is a 28-year-old female who sustained a closed left distal tibial shaft fracture with an associated fibular fracture following a twisting injury to her leg. Initially the patient was placed in a long leg splint in the Emergency Department to stabilize her fractured tibia and fibula, with plans to conduct operative fixation. Upon presentation, the physical exam demonstrated that the patient was neurovascularly intact and did not have any evidence of compartment syndrome.
Soviet Perspectives and Policies toward Reactionary Regimes in the Developing World

In their assessments during the 1960s and 1970s of the state of affairs of Third World “revolutionary democracies” and nations that had taken the “non-capitalist road to development,” the Soviets employed a mode of analysis based on the “correlation of forces.” Given the seeming successes of these “revolutionary democracies” and the appearance of new ones, Moscow was clearly heartened by the apparent tilt in favor of the Soviets and of “progressive” humanity more generally. These apparently positive trends were reflected in Soviet perspectives and policies on the Third World, which focused confidently on such “progressive” regimes. Nonetheless, so-called “reactionary” regimes continued to be a thorn in the side of Soviet policy makers. This study offers a fresh examination of the Soviet analyses of, and policies towards three “reactionary” Third-World regimes: the military dictatorship in Brazil, the Pinochet dictatorship of Chile, and Iran during the reign of the Shah. The article reveals that Soviet decision makers and analysts identified the state sector as the central factor in the “progressive” development of the Third World. Hence the state sector became the focal point for their analyses and the touchstone for Soviet policies; the promotion of the state sector was regarded as a key to the Soviet objective of promoting the “genuine independence” of Third World countries from imperialist domination.
The Stener Lesion: Historical Perspective and Evolution of Diagnostic Criteria:

Background: In 1962, Bertil Stener first described the anatomy and treatment of the displaced ulnar collateral ligament of the metacarpophalangeal joint, later called the Stener lesion. Since Stene...
Theory from the Oster Laboratory Leaps Ahead of Experiment in Understanding Actin-Based Cellular Motility.

By the early 1990s, most biophysicists and cell biologists agreed that polymerization of actin filaments at the leading edge of a motile cell pushes the plasma membrane forward, creating a protrusion that extends the border of the cell (Fig. 1). For cells on a flat substrate, like a microscope slide, this leading edge is a relatively flat lamella less than 1 μm thick. To balance protrusion at the front end, contractility of the cytoplasm was believed to pull the rear of the cell forward toward attachments that form continuously behind the leading edge.
Improving WLAN-based indoor mobile positioning using sparsity

Growing demand for Indoor Localization and Navigation, and the increasing importance of Location Based Services (LBS) necessitates methods that can accurately estimate the position of mobile devices in environments where GPS does not work properly. In this paper, we propose a novel localization method that uses spatial sparsity to improve indoor mobile positioning. The simulation results show the high performance of the proposed method and its robustness to multipath conditions compared to other existing methods. The proposed method has less complexity, less cost and higher robustness to configuration changes compared to common methods such as RSS Fingerprinting approaches.
Sexual desire during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women's Health Study.

Abstract Aims: To describe levels of sexual desire across the menopausal transition (MT) and early postmenopause (PM), including effects of age, MT-related factors, health, stress, symptoms (hot flash, sleep, mood), and social opportunity factors. Methods: A subset of Seattle Midlife Women's Health Study (SMWHS) participants who provided data during the early reproductive, early and late menopausal transition stages, or postmenopause (n = 286), including menstrual calendars for staging the MT, annual health reports between 1990 and 2005, and morning urine samples assayed for estrone glucuronide (E1G), testosterone (T), and follicle-stimulating hormone (FSH) was included. Multilevel modeling using the R program was used to test factors related to sexual desire. Results: Women experienced a significant decrease in sexual desire during the late MT stage (p < 0.01) and early PM (p < 0.0001). Those with higher urinary E1G and T reported significantly higher levels of sexual desire, whereas those with higher FS...
Differential dynamic microscopy of bidisperse colloidal suspensions

Research tasks in microgravity include monitoring the dynamics of constituents of varying size and mobility in processes such as aggregation, phase separation, or self-assembly. We use differential dynamic microscopy, a method readily implemented with equipment available on the International Space Station, to simultaneously resolve the dynamics of particles of radius 50 nm and 1 μm in bidisperse aqueous suspensions. Whereas traditional dynamic light scattering fails to detect a signal from the larger particles at low concentrations, differential dynamic microscopy exhibits enhanced sensitivity in these conditions by accessing smaller wavevectors where scattering from the large particles is stronger. Interference patterns due to scattering from the large particles induce non-monotonic decay of the amplitude of the dynamic correlation function with the wavevector. We show that the position of the resulting minimum contains information on the vertical position of the particles. Together with the simple instrumental requirements, the enhanced sensitivity of differential dynamic microscopy makes it an appealing alternative to dynamic light scattering to characterize samples with complex dynamics.
Population health management: An independent physician organization approach

Purpose The role of clinical pharmacists and their impact on population health and value-based contracts within a multidisciplinary care management team are described. Summary The Greater Rochester Independent Practice Association (GRIPA) has promoted high-quality, value-based care since its foundation 20 years ago. One of several ways that GRIPA enables its physicians to succeed in shared-savings agreements is by providing a community-based multidisciplinary care management team. The multidisciplinary team’s primary goal is to help physicians manage the care of their most costly and complex patients. In addition, clinical pharmacists concentrate on lowering the amount of money spent on medications. The outcome goals for this team include (1) reducing hospitalizations, emergency room visits, and the use of unnecessary or inappropriate medications and (2) improving medication adherence and other measurable outcomes. Care management provided by clinical pharmacists for patients meeting GRIPA’s high-risk criteria (≥2 inpatient or ≥3 emergency room visits in the 12 months before care management engagement) between 2013 and August 2015 resulted in a 42% decrease in 30-day readmissions, a 45% decrease in hospital admissions, a 16% decrease in emergency room visits, and a 20% decrease in annual medical charges. Through individualized pharmacy reviews and a unique approach to managing high-cost drugs, the clinical pharmacists at GRIPA have been successful in reducing hospitalizations and emergency room visits as well as promoting appropriate use of medications while reducing pharmacy waste. Conclusion As part of a multidisciplinary team, clinical pharmacists are able to optimize medication use and engage patients and physicians to reduce medical and medication costs for contracted patients.
Virus Transformation as a Function of Age, Differentiation and Hereditary Factors

Neoplastic transformation of cell cultures has become a powerful tool to analyze the multiple steps involved in carcinogensis. Such in-vitro transformation of mammalian cells has been shown to occur after exposure to DNA- or RNA-oncogenic viruses, ionizing irradiation and chemical carcinogens (1–4). In most instances, dispersed monolayer cultures of freshly explanted cell strains or established cell lines have been used for such assays. Multiple parameters have been defined to assess in-vitro transformations (5). Much less precise information is available for cultures of differentiated cells or embryonal, fetal or neonatal organ cultures and their responses to carcinogenic stimuli. In particular, the interrelationship between the differentiated state of a target organ and susceptibility to carcinogenesis remains largely unexplored. Even the in-vitro responses of dispersed cells derived at various ages from the host deserve further attention if a correlation between potential target cells and host age is to be explained at the mechanistic level.
Can Boethics Escape from Biopolitics

The emergence of biopolitics and bioethics are closely related. They not only focus on ‘bio,’ life in a wide and abstract sense, but also reach beyond the individual subject and beyond theoretical rationality. But instead of developing as two related discourses, bioethics has in fact become the dominant manifestation of biopolitics itself. Bioethics has generated a political regime, a system of governance that administers, fosters and secures life as a form of ‘biopower,’ controlling the population and disciplining the individual. This emergence of biopower is closely linked to the ideology of neoliberalism since it emphasizes internal regulation by autonomous subjects rather than external force and pressure.