cssi/SciSciGPT-SciSciNet huggingface dataset:
Sharp spectral bounds of several graph parameters using eigenvector norms

Abstract We investigate the role of the 1- and ∞-norms of eigenvectors in spectral graph theory. In particular, we produce several randomized algorithms which show that various graph-theoretic parameters can be tightly bounded by the eigenvalues as well as norms of the corresponding eigenvectors. Further, in some cases, these inequalities can determine the parameters exactly. Our results include: a spectral bound for the densest subgraph problem, an adapted “converse” to the Expander Mixing Lemma, and an adapted spectral approach to the maximum cut problem.
Emerging adulthood themes and hookah use among college students in Southern California.

Abstract Introduction Hookah (or waterpipe) use is increasing worldwide with implications for public health. Emerging adults (ages 18 to 25) have a higher risk for hookah use relative to younger and older groups. While research on the correlates of hookah use among emerging adults begins to accumulate, it may be useful to examine how transition-to-adulthood themes, or specific thoughts and feelings regarding emerging adulthood, are associated with hookah use. This study determined which transition-to-adulthood themes were associated with hookah use to understand the risk and protective factors for this tobacco-related behavior. Methods Participants (n = 555; 79% female; mean age 22) completed surveys on demographic characteristics, transition-to-adulthood themes, hookah, and cigarette use. Results Past-month hookah use was more common than past-month cigarette use (16% versus 12%). In logistic regression analyses, participants who felt emerging adulthood was a time of experimentation/possibility were more likely to report hookah use. However, transition-to-adulthood themes were not statistically significantly related to cigarette use. Conclusions The profile for hookah use may differ from that of cigarettes among emerging adults. Themes of experimentation/possibility should be addressed in prevention programs on college campuses and popular recreational spots where emerging adults congregate. These findings can inform future studies of risk and protective factors for hookah use among emerging adults.
Who Owns This Article? Applying Copyright’s Work-Made-for-Hire Doctrine to Librarians’ Scholarship

The Copyright Act of 1976 provides that works—including scholarship—written within the scope of employment belong to employers. But copyright law and actual practices widely diverge. The academic community generally allows librarians to claim ownership of their writing, even when that ignores copyright law. Mr. Hellyer supports copyright ownership by librarians, and calls for the law and common practices to be harmonized.
Free Exercise and the Resurgence of the Religious Freedom Restoration Act

This article considers the development of protections of the Free Exercise of Religion, initially under the First Amendment, and later, following Congress’s discontent with the Supreme Court’s deci...
Innovations in Public Health Law: Exploring New Strategies

In 2012, faculty and students from the Beazley Institute for Health Law and Policy at the Loyola University Chicago School of Law and the Public Health Law and Policy Program at the Sandra Day O’Connor College of Law at Arizona State University began collaboration on a Special Edition of the Annals of Health Law focusing specifically on innovations in public health law and policy. Building on the two programs’ unique strengths, this Special Edition represents our dual programs’ commitment to align in the production of outstanding scholarship to advance the field of public health law.
Study of current control strategy of STATCOM based on LCL filter under distorted grid conditions

In order to improve the filtering performance of the system with small inductor, LCL filter is selected as the output filter of distribution static synchronous compensator(D-STATCOM). LCL filter is a three-order system, the resonant peak may result in the instability of system. State-feedback control based on virtual impedance is proposed to suppress the resonant peak, which reduces system losses compared with passive damping. The grid voltage harmonics result in the distortion of compensation current, which makes the compensation current not track its reference. A multi-resonance proportional resonant. (PR) regulator is proposed to increase the grid input impedance at a specific frequency, which rejects the disturbance of grid harmonics and improves the current tracking performance. Simulation and experimental results prove the validity of this method.
Painful Pseudotendon of the Flexor Carpi Radialis Tendon: A Literature Review and Case Report.

Background: Flexor tendon ruptures in the wrist are uncommon. Flexor carpi radialis (FCR) tendon rupture can occur in rheumatoid patients, following cortisone injection for tenosynovitis, and follo...
Youth Access to School Salad Bars in the United States—2011 to 2014:

Purpose:To examine differences in students’ access to school salad bars across sociodemographic groups and changes in availability over time.Design:Nonexperimental.Setting:Nationally representative...
Redefining the Food component of U.S. foreign policy

The Rural Urban Food Systems (RUFoS) project is a two-part technical project, sponsored by the Office of Global Food Security at the U.S. Department of State (SGFS), which aims to evaluate different strategies for integrating urban food security into United States global food security foreign policy, and develop a methodology for choosing an appropriate test site for the RUFoS concept. This project is conducted for the SGFS under the State Department's Diplomacy Lab program. The project will compare and rank rural, urban, and RUFoS-focused initiatives based on the criteria of food security, livelihoods, sustainability, and value chains. The ultimate ranking will help determine which food system policies and strategies most successfully alleviate poverty and food insecurity along the continuum of settlements from rural villages to urban centers, while building capacity for improved and sustainable livelihoods. Five countries - Ethiopia, Zambia, South Africa, Nepal, and Cambodia - were selected for evaluation of food security strategies in different local contexts. Through our analysis, we concluded that the RUFoS strategy has the greatest potential for positive impact on food security as it improves livelihoods and food security across the entire rural-urban continuum. Next, at the request of the client, we evaluated countries and subsequent cities in Southeast Asia and Sub-Saharan Africa to create a methodology for identifying an optimal RUFoS test site. We recommend that United States Global Food Security policy pursue the RUFoS strategy and implement it using the methodology we developed to select the test country and city.
NCCTG N1174: Phase I/comparative randomized phase (Ph) II trial of TRC105 plus bevacizumab versus bevacizumab in recurrent glioblastoma (GBM) (Alliance).

2023Background: TRC105 is a humanized antibody targeting CD105 (endoglin), a member of the TGFβ receptor superfamily. CD105 is expressed in glioma stem cells and circulating endothelial cells (CECs...
Absence and ‘presence’: el-Hadhra and the cultural politics of staging Sufi music in Tunisia

ABSTRACTSufisms in North Africa are both esoteric and exoteric; that is, they harbour hidden forms of knowledge and experience known only to initiates but perform them regularly in rituals that are public or semi-public, making them accessible to all. When musics of these rituals are brought onto the concert stage, then, they pose analytical challenges to binaries such as spectatorship/participation, loss/renewal and authenticity/inauthenticity. In Tunisia, the staging of Sufi music has been monopolised for decades by a staged spectacle called el-Hadhra, which, along with its offshoots and competitors, proceeds according to a modular logic of culture in which music, dance, trance and other aspects of ritual are approached as separable, extractable and available for recombination in a plug-and-play manner. This paper unpacks the implications of this logic of modularity through a close reading of el-Hadhra that focuses on strategies of minimising and maximising the ‘contextual gap’ between ritual and stage ...
Bone Tissue Engineering: Clinical Challenges and Emergent Advances in Orthopedic and Craniofacial Surgery

Abstract Bone tissue engineering is concerned with creating implantable bone substitutes for critical skeletal defects that cannot heal on their own. These defects are common clinical scenarios in orthopedics and craniofacial surgery, for the treatment of bone loss due to trauma, infection, and tumor resection. In the conventional tissue-engineering paradigm, combinations of cells and bioactive molecules are seeded onto three-dimensional biomaterial scaffolds to create an implantable ‘osteogenic’ implant. To date and despite numerous exciting advances in preclinical models, regulatory approval barriers, business challenges, and related intellectual property lifecycle issues have impeded clinical translation from the bench to the bedside. Despite these hurdles, there are clinical case reports of ingenious reconstructions of challenging diaphyseal and craniofacial defects that borrow from first principles of conventional tissue engineering, but circumvent the regulatory process via ‘off-label’ use of several approved products at the point-of-care. While placebo-controlled, prospective clinical studies of efficacy and safety still needs to be pursued for bone tissue engineering, these point-of-care innovations usher in the era of personalized regenerative medicine, and may serve as the bridge to wide clinical translatability and adoption of bone tissue-engineering approaches and products. Novel molecules that regenerate bone in clinically relevant defects are being developed and, when successfully launched, will act as bone healing agents.
High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells.

Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic receptor involved in the uptake of a variety of molecules, such as apoE, α2-macroglobulin, and the amyloid β peptide (Aβ), for either transcellular transport, protein trafficking or lysosomal degradation. The LRP1 gene can be transcribed upon activation of peroxisome proliferator receptor activated-γ (PPARγ) by the potent PPARγ agonist, rosiglitazone (RGZ). In previous studies, RGZ was shown to upregulate LRP1 levels in concentrations between 0.1 and 5 μM in HepG2 cells. In this study, we sought to replicate previous studies and to investigate the molecular mechanism by which high concentrations of RGZ reduce LRP1 levels in HepG2 cells. Our data confirmed that transcriptional activation of LRP1 occurred in response to RGZ at 3 and 10 μM, in agreement with the study reported by Moon and collaborators. On the other hand, we found that high concentrations of RGZ decreased both mRNA and protein levels of LRP1. Mechanistically, transcriptional dysregulation of LRP1 was affected by the downregulation of PPARγ in a time- and concentration-dependent manner. However, downregulation of PPARγ was responsible for only 40% of the LRP1 reduction and thereby the remaining loss of LRP1 (60%) was found to be through degradation in the lysosomal system. In conclusion, our findings demonstrate the mechanisms by which high concentrations of RGZ caused LRP1 levels to be reduced in HepG2 cells. Taken together, this data will be helpful to better explain the pharmacological modulation of this pivotal membrane receptor by PPARγ agonists. Keywords: LRP1, rosiglitazone, PPARγ, protein degradation, lysosomal degradation, Bafilomycin A1.
Unpacking barriers to healthy lifestyles from the perspective of youth with disabilities and their parents.

ABSTRACTAdolescents and young adults with disabilities experience several health inequalities and challenges in maintaining healthy lifestyles. As a group, individuals with disabilities experience ...
Fast Multi-image Matching via Density-Based Clustering

We consider the problem of finding consistent matches across multiple images. Current state-of-the-art solutions use constraints on cycles of matches together with convex optimization, leading to computationally intensive iterative algorithms. In this paper, we instead propose a clustering-based formulation: we first rigorously show its equivalence with traditional approaches, and then propose QuickMatch, a novel algorithm that identifies multi-image matches from a density function in feature space. Specifically, QuickMatch uses the density estimate to order the points in a tree, and then extracts the matches by breaking this tree using feature distances and measures of distinctiveness. Our algorithm outperforms previous state-of-the-art methods (such as MatchALS) in accuracy, and it is significantly faster (up to 62 times faster on some benchmarks), and can scale to large datasets (with more than twenty thousands features).
Prevalence of Nephrolithiasis in Patients with Chronic Liver Disease: A Case-Control Study.

Background and aims Nephrolithiasis is known to be associated with several systemic diseases including chronic kidney disease and renal failure, which can also occur as a complication of chronic liver disease (CLD). This study aimed to assess the prevalence of nephrolithiasis in patients with CLD. Methods A short survey was completed by 198 patients with CLD and 322 controls matched by age, sex, and state of residence. A primary diagnosis of liver disease was confirmed with health record review. Results The median age of the liver disease group was 63 years and 128 (65%) were male; the median age of the control group was 63 and 199 (63%) were male. Body mass index was higher in the liver disease group (27.8 vs 26.7, P Conclusions In this case–control, survey-based study, the prevalence of nephrolithiasis was 2 times higher in patients with CLD.
Developing HALM Teaching Competencies in PETE Teacher Candidates

The lifetime activities approach, which grew out of the lifetime physical activity model, has informed the practice of one physical education teacher education (PETE) program as it prepares teacher candidates to teach K–12 students about the importance of health, health-related fitness, and physical activity. Health-enhancing behaviors such as healthy eating habits, using stress management techniques, and healthy sleep behaviors are also introduced to students. This article describes activities that are presented to help PETE teacher candidates develop healthy and active lifestyle management (HALM) teaching competencies. Two HALM teaching competencies (one-minute HALM tips and object lessons) are defined, and a description of where they appear in the curriculum and how they are assessed after field teaching of K–12 students is provided.
Evaluating dendritic cells as an in vitro screening tool for immunotherapeutic formulations

Abstract Immunotherapy approaches targeting dendritic cells (DCs) are being studied as treatment options in cancer. This project focused on utilizing DCs as a valuable in vitro screening tool for efficacious microparticle formulations containing tumor associated antigens (TAAs) and adjuvants as immunotherapy alternatives. The innate immune system, including DCs, distinctly responds to the particulate matter and adjuvants in these formulations which stimulates the adaptive immune system to eliminate resident cancer cells. We formulated microparticles (MPs) co-loaded with TAAs along with the adjuvants, AddaVax™ and Imiquimod, and measured their effect on DCs in eliciting a cell-mediated immune response towards tumors. The MP zeta potential was measured as −24.0 mV and −26.5 mV for blank and TAA/adjuvant co-loaded microparticles, and the average particle size was 671.2 nm and 854.4 nm respectively. We determined that nitric oxide (NO) secretion was significantly higher in the adjuvant MP treated DCs group and was dose dependent with 1 mg/mL demonstrating the highest secretion levels. TNF-α release was highest in AddaVax™/TAA and Imiquimod/TAA MPs treated DCs, while IL-6 secretion was highest from Imiquimod/TAA MPs as well as from combined AddaVax™/TAA and Imiquimod/TAA MPs. Overall, the cell surface marker expressions of CD80, CD86, CD40, CD54, MHC-I and MHC-II levels were highest with combined AddaVax™/TAA and Imiquimod/TAA MPs. The results of our experiments suggest that a combination of adjuvants targeting different DC receptors loaded with TAA MPs creates an efficient delivery system to T-cells that could improve adaptive immune responses. Our studies also confirm that DCs are potent innate immune cells that can be used successfully as an in vitro tool to screen novel delivery formulations focused on immunotherapy.
Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death

The tumor suppressor protein p53 is central to the cellular stress response and may be a predictive biomarker for cancer treatments. Upon stress, wildtype p53 accumulates in the nucleus where it enforces cellular responses, including cell cycle arrest and cell death. p53 is so dominant in its effects, that p53 enforcement - or - restoration therapy is being studied for anti-cancer therapy. Two mechanistically distinct small molecules that act via p53 are the selective inhibitor of nuclear export, selinexor, and MDM2 inhibitor, nutlin-3a. Here, individual cells are studied to define cell cycle response signatures, which captures the variability of responses and includes the impact of loss of p53 expression on cell fates. The individual responses are then used to build the population level response. Matched cell lines with and without p53 expression indicate that while loss-of-function results in altered cell cycle signatures to selinexor treatment, it does not diminish overall cell loss. On the contrary, response to single-agent nutlin-3a shows a strong p53-dependence. Upon treatment with both selinexor and nutlin-3a there are combination effects in at least some cell lines - even when p53 is absent. Collectively, the findings indicate that p53 does act downstream of selinexor and nutlin-3a, and that p53 expression is dispensable for selinexor to cause cell death, but nutlin-3a response is more p53-dependent. Thus, TP53 disruption and lack of expression may not predict poor cell response to selinexor, and selinexor's mechanism of action potentially provides for strong efficacy regardless of p53 function.
Intrawound vancomycin in primary hip and knee arthroplasty: a safe and cost-effective means to decrease early periprosthetic joint infection.

Abstract Background Periprosthetic joint infection (PJI) is a devastating complication after hip and knee arthroplasty. Intrawound vancomycin has been described extensively in the spine literature; however, information regarding use in arthroplasty is limited. We investigate the efficacy and safety of intrawound vancomycin in arthroplasty surgery. Methods All primary total hip and knee arthroplasty cases (n = 460) performed by a single surgeon from April 2016 to October 2017 were reviewed. Starting in October 2016, intrawound vancomycin was used in all total joints. Baseline characteristics, infection rates, 90-day readmission, and other complications were compared between untreated subjects and those who received intrawound vancomycin. In addition, cost data were considered. Mean follow-up durations for the control and vancomycin groups were 11.3 and 7.7 months, respectively. Results Baseline characteristics and comorbidities were similar for the control (n = 112) and vancomycin groups (n = 348). The vancomycin cohort demonstrated decreased both overall infection rate (0.57% vs 2.7%; P = .031) and PJI rate (0.29% vs 2.7%; P = .009) compared with the untreated group. There was no statistical difference in incidence of ototoxicity or acute kidney injury. Although there was no difference in overall 90-day readmission rate, the vancomycin subset demonstrated lower readmission rate due to infection (0.57% vs 2.7%; P = .031). Based on the cost of vancomycin powder and calculated number needed to treat (NNT = 47.5), the cost to prevent 1 infection with the addition of intrawound vancomycin was $816. Conclusions These findings suggest that intrawound vancomycin may be a safe, cost-effective means that shows promise in reducing PJI in early follow-up. Future prospective studies are warranted.
Every patient should be enabled to stop the line

When Taiichi Ohno introduced ‘Stop the Line’ manufacturing, people were sceptical.1 2 Each assembly line worker was entrusted with the responsibility to push a red button to stop the line if she/he noticed something wrong. The idea was to catch problems early, before they got out of control. But the approach seemed at odds with production goals, namely keeping assembly lines running at full speed. Why not have managers, more trained in production, oversee the line and make fewer stops? Ohno’s idea seemed too risky to some managers, who resisted. Indeed, managers who implemented Stop the Line experienced a productivity drop. Investigating and fixing problems took time. But soon, things flipped. The teams using Stop the Line were faster and more reliable than those that did not and Stop the Line manufacturing became a standard Toyota approach. When patients enter the hospital, they entrust clinicians to push a red button if they sense something wrong. But patients themselves, increasingly championed as ‘members of the team’ and ‘co-producers’ of health, are not always given a button nor taught how to use it.3–5 Patients and families—vigilant stakeholders—hold unique knowledge and can make important contributions to patient safety, having repeatedly demonstrated the ability to identify problems in care, including ones missed by clinicians.6–11 Parents, like James Titcombe, whose son died 9 days after birth from a delayed sepsis diagnosis, are often the first to detect important clues in their child’s course.12–14 Patients like Serena Williams, who correctly suspected a postpartum pulmonary embolism but was initially unheeded by her care team, may be the first to know something is wrong.15 In this issue of BMJ Quality & Safety , Fisher and colleagues16 studied patients’ speaking up to enable organisational learning. Adding a new question to the Hospital Consumer …
Smartphone colorimetric detection of calcium and magnesium in water samples using a flow injection system.

Abstract Water hardness has implications for both human health and industry. The main components that make water hard are calcium and magnesium. The magnesium in hard water may provide a moderate health benefit, but calcium can cause serious problems in industrial processes. This paper presents a rapid-response, reliable and convenient device developed to measure calcium and magnesium ion concentrations continuously in water samples by using a smartphone analysis of colorness change. The ion detection is based on phase extraction equilibria in a specific ion-exchange substance membrane that contains an ionophore (selectively binding to specific ions), a chromoionophore (a lipophilic pH indicator), an ionic salt (a cation exchanger), a polymer (PVC) and a plasticizer. The device is built on a PDMS fluidic layer with six parallel detection chambers that allows the water samples to flow through at a specific rate to these chambers. An Android smartphone App was developed to acquire the color images after the ions exchange across the membrane, and the analysis of target ion concentration can be realized by the pre-loaded calibration curves. The results show that the colorimetric sensor is capable of determining Ca2+ concentration in an acetate buffer solution (pH = 5.3) and total hardness in a Tris-HCl buffer solution (pH = 7.2), covering the range of normal water hardness (from soft to very hard). The measurements on real samples were analyzed by both Image J and the App and were compared with results from a commercial hardness kit and inductively coupled plasma mass spectrometry (ICP-MS), demonstrating the accuracy and precision of our colorimetric sensor compared to a commercial sensor. This cost-effective device and automatic analytical smartphone app can be combined easily as a ready-to-go sensor for monitoring Ca2+ and Mg2+ continuously and simultaneously, which is convenient for use in resource-limited areas.
X-Ray Doppler Imaging of 44i Bootis with Chandra

Chandra High-Energy Transmission Grating observations of the bright eclipsing contact binary 44i Bootis show X-ray line profiles that are Doppler-shifted by orbital motions. The X-ray emission spectrum contains a multitude of lines superposed on a weak continuum, with strong lines of O VIII, Ne X, Fe XVII, and Mg XII. The profiles of these lines from the total observed spectrum show Doppler-broadened widths of ~550 km s-1. Line centroids vary with orbital phase, indicating velocity changes of greater than 180 km s-1. The first-order light curve shows significant variability but no clear evidence for either primary or secondary eclipses. Flares are observed for all spectral ranges; additionally, the light curve constructed near the peak of the emission measure distribution [Te = × 106 K] shows quiescent variability as well as flares. The phase dependences of line profiles and light curves together imply that at least half of the emission is localized at high latitude. A simple model with two regions on the primary star at relatively high latitude reproduces the observed line profile shifts and quiescent light curve. These first clear X-ray Doppler shifts of stellar coronal material illustrate the power of Chandra.
Music Teacher Rankings of Selected Core Teaching Practices

There is a decades-long history of music education researchers examining characteristics and skills associated with effective teaching and assessing how preservice music teachers develop those comp...
Improving relationship quality in group care settings: The impact of implementing the CARE model

Abstract The current study examined the effects of implementing a new program model on the quality of relationships between direct care providers and residents in group care agencies. Children and Residential Experiences (CARE), an organization-wide program model that involves a range of structural change and staff-development activities, was implemented in 13 group care agencies in one Southeastern state. CARE implementation lasted three years and involved the application of six evidence-informed principles throughout the organization in order to create more therapeutic environments and improve the quality of care for children. We used a stepped-wedge design in which one cohort of agencies began CARE immediately and a second cohort waited 12 months before beginning, allowing them to serve as a comparison group during the waiting period. Children in each agency were surveyed annually about the perceived quality of their relationships with staff using a new instrument developed for this study. Results of a linear mixed model indicated that after accounting for clustering at the agency and cottage levels and controlling for several important covariates, child perceptions of relationship quality increased significantly in the three years after CARE implementation began. The strength of the CARE effect was stronger for residents with several previous placements, but did not differ by age, gender, race, length of stay, DSS referral, or problem behavior. Results provide evidence that supports the effectiveness of CARE as an intervention to help group care agencies improve the quality of children's daily interactions with caregiving staff, a critical aspect of their experience while living in care. The process requires a long-term commitment and an organization-wide focus on serving the best interests of children.
New Instrumental Methods: Summary of the Panel Discussion

The panel discussion on new instrumental methods added an important appendix to the material presented in the other sessions of the Institute. Highlighted in the discussion were three topics experiencing particularly rapid growth including ion cyclotron resonance (ICR) spectroscopy, the selected ion flow tube (SIFT), and beam methods. I am indebted to Drs. Melvin Comisarow, John Eyler, Gerard Mauclaire, Nigel Adams, Norman Twiddy, Martin Jarrold, David Hirst, and Ron Gentry for providing abstracts used in preparing this summary.
Triweekly carboplatin alone in the treatment of oropharyngeal carcinoma with definitive concurrent chemoradiation: Outcomes of 120 unselected patients and a comparison to the RTOG 0129 regimen results.

e16031 Background: In 2002, due to the significant toxicities associated with triweekly high-dose cisplatin, we decided to routinely use triweekly carboplatin in the treatment of locally advanced h...
WHERE CHA2DS2-VASC FAILS: THROMBOEMBOLIC RISK WITH ATRIAL FIBRILLATION IN PREGNANCY

Atrial fibrillation (AF) is the most common arrhythmia of pregnancy. While CHA2DS2-VASc is the standard commonly used to assess thromboembolic (TE) risk, the calculator falls short in pregnancy as it does not address the increased thrombophilia of pregnancy. Thus, assessing TE risk in patients
Enhanced Cancer Models Database (caMOD) accommodates more species and provides pre-clinical trials information

788 The Cancer Models Database (caMOD) is a web-based resource that provides information about animal models for human cancers. Key capabilities are Submission, Search, and System Administration. The application can be accessed at http://cancermodels.nci.nih.gov. With version 2.3, caMOD customizes the application for models in a variety of species beyond mouse models. caMOD 2.3 supports the submission of zebrafish and rat models. Depending on the selected species, the application uses species-specific vocabularies for anatomy and disease throughout the application. Links to the Zebrafish Model Organism Database (http://www.zfin.org) and to the Rat Genome Database (http://rgd.mcw.edu/) allow the user to retrieve information about the modified alleles. Links to the above mentioned resources have also been added to the publication listings. Data about other species can be submitted to caMOD, but no vocabularies for anatomical or diagnostic terms are provided at this time. caMOD 2.3 further expands the use of vocabularies provided by NCI Thesaurus (http://nciterms.nci.nih.gov) by introducing the staining method vocabulary to the imaging portion of the application. The most recent release of caMOD connects the cancer models database with caELMIR, the Cancer Electronic Laboratory Management Information Resource (http://caelmir.compmed.ucdavis.edu/caelmir/). Users can retrieve data generated from preclinical trials and review information on the study, experiment, and individual animal level. Funded by NCI Contract N01-CO-1240
"It feels like home": Transgender youth in the Midwest and conceptualizations of community climate.

Community climate toward sexual and gender minority (SGM) youth is associated with higher rates of victimization and poorer health and wellbeing-related outcomes such as depression and suicidal ideation. However, this field of research has underemphasized the experiences of transgender youth, particularly within the Midwestern context which is marked by vast rurality and characterized as sociopolitically conservative. Using qualitative and community-based methods, this study identified factors that impact community climate from the perspective of transgender youth (n = 19) in the Midwest and situated them within the Ecological Systems Theory (EST). Thematic analysis of interviews revealed four themes: resources, visibility, policies, and ideologies. Themes often crossed levels within the EST, indicating the complexity and interrelated nature of climate across local, regional, and national contexts. Implications for theory, research, and practice are discussed.
Interesting PET/CT cases with unusual findings

1197 Introduction: In this educational poster, we present three F-18 FDG (Fluorodeoxyglucose) PET/CT cases with interesting findings. First two patients had unusual presentation of diffuse large B cell lymphoma. Third patient had FDG avid lipomatous hypertrophy of interatrial septum. Findings:First Case: 51 year old man initially presented with cough, Gastroesophageal Reflux and progressive symptoms of jaundice and fatigue. He was admitted to the hospital with febrile neutropenia and CT scan showed splenomegaly as well as lymphadenopathy above and below the diaphragm. Neck mass biopsy confirmed diagnosis of diffuse B-cell lymphoma. Staging PET-CT demonstrated diffuse intense FDG uptake in the enlarged liver, heterogenous uptake in the enlarged spleen along with avid lymphadenopathy. Second Case: 44 year old woman initially presenting with unintentional weight loss, fatigue and vaginal bleeding. Bone marrow biopsy revealed high grade diffuse B-cell lymphoma. PET-CT demonstrated diffuse intense radiotracer uptake within the kidneys, spleen, uterus, lower genital tract and bone marrow. The spleen and kidneys were also enlarged. Patient was started on systemic chemotherapy and post-treatment PET-CT demonstrated very good response to therapy with resolution of abnormal metabolic activity. Third Case: 67 year old woman with history of tobacco use presented with squamous cell carcinoma of the tongue. Staging PET-CT demonstrated intense focal uptake in the tongue as well as incidental finding of lipomatous hypertrophy of the interatrial septum. These findings were also seen on the diagnostic Chest CT.
Management strategies for Alternaria leaf blight on American ginseng

Abstract Cultivated American ginseng (Panax quinquifolius) is a perennial herb valued as a traditional Chinese medicine. The crop is commercially produced under polypropylene shade cloth, creating a climate favorable for leaf blight caused by Alternaria panax; frequent fungicide applications are required annually to protect yields of the root and seed. Our objective was to improve Alternaria leaf blight tactic by identifying effective products and application intervals using a calendar or the TOM-CAST disease forecaster. Product efficacy trials were conducted at two sites over two years and included 14 products and an untreated control. The fungicides pyraclostrobin and azoxystrobin + difenoconazole were consistently effective in limiting leaf blight compared to the untreated control. Fluxapyroxad + pyraclostrobin was also effective both years across both sites with one exception. Mancozeb, fluazinam, chlorothalonil, difenoconazole, and penthiopyrad were effective when disease pressure was not severe. Applications of pyraclostrobin or mancozeb resulted in a higher seedhead yield than the untreated control. The TOM-CAST disease forecaster, with spray thresholds of 10 or 15 disease severity values (DSVs) was tested at four field sites for each of two years and compared to fungicides applied every 7 or 10 days or not applied (untreated control). All treatments at three of the four sites limited disease severity compared to the untreated control in both years. According to the area under the disease progress curve (AUDPC) data, fungicide treatment programs in 2013 were similar and better than the untreated control. The AUDPC data from 2014 indicated that the 7-day application treatments had fewer diseased plants than the untreated control at all sites; the TOM-CAST 10 and 15 DSV treatments limited disease compared to the untreated control at three of the four sites. The TOM-CAST 10 DSV treatment yielded similarly to the 10-day treatment at one site for both fresh and dried root; the TOM-CAST 10 and 15 DSV treatment yields were similar. At a second site, fresh and dried root yields were similar for the 7-day and TOM-CAST 10 DSV treatments; 10-day and TOM-CAST 15 DSV treatments were similar. TOM-CAST 10 DSV may provide a balance between reducing fungicide applications while protecting valuable ginseng root yields.
Rate-Distance Tradeoffs for List-Decodable Insertion-Deletion Codes.

This paper presents general bounds on the highest achievable rate for list-decodable insertion-deletion codes. In particular, we give novel outer and inner bounds for the highest achievable communication rate of any insertion-deletion code that can be list-decoded from any $\gamma$ fraction of insertions and any $\delta$ fraction of deletions. Our bounds simultaneously generalize the known bounds for the previously studied special cases of insertion-only, deletion-only, and zero-rate and correct other bounds reported for the general case.
Outcomes of a higher calorie inpatient refeeding protocol in Asian adolescents with anorexia nervosa.

OBJECTIVE This study aims to compare the outcomes of higher calorie refeeding (HCR) and a lower calorie refeeding (LCR) methods among a diverse sample of young Asian adolescents admitted to a tertiary institution in Asia for management of anorexia nervosa (AN). METHOD This is a retrospective case control study of Asian adolescents who were managed using an inpatient HCR protocol (2016-2017) and an LCR protocol (2010-2014). Baseline characteristics, daily change in percent median body mass index (%mBMI), and rates of refeeding hypophosphatemia were analyzed between groups. RESULTS A total of 125 adolescents with AN were analyzed with 61 (52%) patients in the HCR group. Mean age was 14.0 years (SD =1.5) and mean presenting %mBMI was 73.2 (SD =6.9) with mean length of stay of 11.9 days (SD = 6.6). Patients in the HCR group had significantly increased rate of change of %mBMI (M = 0.39, SD = 0.31) than patients in the LCR group (M = 0.12, SD = 0.43) (p < .001). There was an increased rate of mild hypophosphatemia in the HCR group (HCR: 46%, LCR: 22%, p = .007) but no difference in rates of moderate hypophosphatemia and no cases of severe hypophosphataemia. Lower presenting %mBMI significantly predicted the phosphate levels (p = .004). DISCUSSION In a sample of Asian adolescents with AN, use of an HCR protocol was associated with improved rate of inpatient weight gain. There was increased risk of mild hypophosphataemia, but not moderate to severe hypophosphataemia, suggesting that an HCR protocol can be used safely with close monitoring of phosphate levels.
Still-restrictive equality in shared school governance: Black parents’ engagement experiences and the persistence of white supremacy in a liberal public school district

This paper draws from a critical race multicase study of Black parents’ school engagement experiences in a liberal U.S. public school district, focusing here on 12 mothers and fathers who participa...
Modeling the cost-effectiveness of adjuvant osimertinib in resected EGFR-mutant non-small cell lung cancer patients.

8527Background: Adjuvant Osimertinib (Osi) was recently approved for resected EGFR-mutant non-small cell lung cancer (NSCLC) based on disease free survival (DFS) benefits from the ADAURA trial. Pri...
Global Cooperation Over Great Power Competition in Afghanistan

Like much of the world’s political discourse, debate about Afghanistan is stuck in a fast-disappearing past. The coronavirus pandemic exposes the fatuity of the U.S. administration’s elevation of “great power competition” as a goal to be pursued rather than an obstacle to be overcome for the sake of the cooperation we need to save our lives. The adoption of great power competition as the lodestar of US foreign policy also creates hurdles for the task of stabilizing Afghanistan, which requires international cooperation.
Automatic adaptive wireless demodulator using incremental learning in real time

In wireless communication systems, a received signal is corrupted by various means, such as noise, multi-path fading, and defects in hardware. To properly demodulate the signal and recover information, complex systems are used. This typically consists of a series of filtering, corrections, timing recovery, and finally demodulation. Furthermore, the approaches for each stage are application specific. Deep learning (DL) can be applied to create an automatic demodulator, independent of modulation type, with no preprocessing, replacing the complex traditional system. However, these systems can only handle scenarios that are incorporated at the initial training stage. If new modulation types are encountered, the system must be re-trained to adapt. Traditional DL systems require the entire original dataset to retain old information, which increases storage requirements and training time. To increase adaptability, we incorporate incremental learning (IL) into a DL demodulator. Incremental learning attempts to overcome these issues, allowing a system to train on only new information. We apply IL to learn to demodulate new modulation types, not initially introduced to this system. We demonstrate this system in the field through the use of software defined radio. The system is subjected to unknown modulation types, and shown to adapt in real-time and over-the-air in an unsupervised environment.
A Study of Lipscomb University Students' Internet Use and Involvement in Extracurricular Activities.

The purpose of this study was to analyze Lipscomb University students' Internet use and involvement in extracurricular activities. A survey of students at Lipscomb University was conducted. As confirmed by the data the research was able to determine that the type of extracurricular activity a student participates in most often is related to the quantity of extracurricular activities they participate in during a typical week. The data also confirmed that the type of extracurricular activity a student participates in most often is related to the amount of time the student spends participating in extracurricular activities during a typical week. The data from the research were insufficient in providing a model that could be used to predict the quantity of extracurricular activities they would participate in during a typical week based on their Internet use. The data were also incapable of building a model that can be used to predict the amount of time per week a student participates in extracurricular activities based on his or her Internet use. Therefore, the data from the research project indicated that students' Internet use does not significantly impact the amount of time spent in extracurricular activities per week or quantity of extracurricular activities per week of students at Lipscomb University. The results of the study led to the author's theory of iStudent Development and iStudent Involvement.
The Relationship Between Work-Life Policies and Practices and Employee Loyalty: A Life Course Perspective

Using a representative sample of 3,381 American workers, this study investigates relationships among work/life policies, informal support, and employee loyalty over the life course (defined by age and parental status and age of youngest child). The central thesis is that our understanding of the impact of work/life policies on employee loyalty will be enriched by consideration of the non-work and work contexts that influence employee attitudes and behavior. The relationship between employee child care policies and loyalty varies for women and men at different stages of parenthood. Flexible-time policies have a consistent, positive association with employee loyalty with some variation based on life stage. Informal support (via supervisors and co-workers) has the greatest positive relationship with employee loyalty.
Nonlinear wave propagation through a random medium and soliton tunneling

We have studied the propagation of non-linear waves across a random medium, using the nonlinear Schrodinger equation with a random potential as a model. By simulating a scattering experiment, we show that non-linearity leads to an improvement of the transmission only when it contributes to create pulses. The propagation properties of these pulses can be described by an equivalent particle theory. Numerical experiments show that this is an approximation: two situations are presented depending on the two ratios of the amplitude and velocity to the perturbation. Concluding remarks link the time-dependent and time-independent regimes.
Neurotensin and Substance P

Publisher Summary This chapter focuses on the peptides, neurotensin (NT) and substance P (SP), and addresses the literature that relates to the potential roles of NT and substance P as hormones or paracrine agents in the gastrointestinal tract. NT is a tridecapeptide with the amino acid sequence: Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu. NT-containing cells appear first in the duodenum in the embryo although in the adult they are largely found in the distal small intestine. Neurotensin has been found in a subpopulation of epithelial cells, called N cells, scattered throughout the intestinal epithelium. The chapter discusses the presence of NT in nerve fibers, tissue determination by radioimmunoassay (RIA) and high-performance liquid chromatographic (HPLC), metabolism of NT released from the intestine, and biological effects of NT on gastrointestinal tissues. SP is an undecapeptide with the amino acid sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2. This sequence is clearly related to those of a number of nonmammalian peptides and to those of the mammalian decapeptides neurokinin α and neurokinin β.
Primary sclerosing cholangitis with normal serum alkaline phosphatase activity

We report 12 cases of primary sclerosing cholangitis (confirmed by cholangiography) in which the serum alkaline phosphatase activity was normal. The enzyme activity remained normal during follow-up in 7 cases and fluctuated in 5 cases (it returned to normal in 4). The presence of advanced histologic stage (fibrosis/cirrhosis) with marked cholangiographic changes in 4 patients establishes that cirrhotic-stage primary sclerosing cholangitis can occur without a concomitant increase in serum alkaline phosphatase activity. Therefore, primary sclerosing cholangitis may exist in an occult state without symptoms or increase in serum alkaline phosphatase activity. Our findings suggest that primary sclerosing cholangitis may be more prevalent than realized, especially in patients who have inflammatory bowel disease. A normal value for serum alkaline phosphatase activity should not preclude further investigation for primary sclerosing cholangitis in patients with inflammatory bowel disease when symptoms or signs suggest liver disease.