cssi/SciSciGPT-SciSciNet huggingface dataset:
Imaging embryonic development with ultrashort pulse microscopy

We report the application of ultrashort pulse microscopy (UPM) for integrated imaging of embryonic development at the tissue, cell, and molecular length scales. The UPM is a multimodal imaging platform that utilizes the broad-power spectrum and high-peak power of 10-fs pulses to render two-photon excited signals and the short coherence gate of such pulses to render optical coherence signals. We show that ultrashort pulses efficiently excite cellular autofluorescence in developing zebrafish embryos such that tissues are readily visualized and individual cells can be monitored, providing a potential method for label-free cell tracking. We also show the ability of ultrashort pulses, without tuning, to excite a broad spectrum of fluorescent protein variants for tracking genetically labeled cell lineages in live embryos, with no apparent damage to the embryos. Molecular information at the mRNA transcript level can also be obtained from embryos that have been stained to reveal the localization of the expression of a gene using NBT/BCIP, which we show can be detected with three-dimensional resolution using a combination of two-photon and optical coherence signals. From this demonstration, we conclude that UPM is an efficient and a powerful tool for elucidating the dynamic multiparameter and multiscale mechanisms of embryonic development.
The Limits of the Homogeneity Model Segregation and Civic Engagement in Latino Communities

Until recently, Latinos generally were well integrated geographically and did not live in concentrated Latino neighborhoods. That is changing. Latinos now are more likely than ever before to live in isolated Latino areas. If this trend continues, Latinos soon will surpass African Americans as the most segregated minority group in the United States. For decades, political scientists, sociologists, and historians have tracked the perils of residential segregation in the African American community, but the consequences of segregation for Latinos in the United States are far from clear. Using the Social Capital Benchmark 2000 survey, this article investigates the civic consequences of segregation. The data suggest that living in a segregated area decreases the likelihood that Latinos participate in community-building activities. These findings directly challenge previous research that purports to find benefits from living in racially homogeneous areas.
An appetitively motivated single-trial learning task for mice.

A maze consisting of 6 successive brightness discriminations was developed as a single-trial appetitive learning task for mice Error and latency measures indicated that significant learning occurred as a result of the single-exposure trial. The utility of this task for assessing treatments altering learning and memory processes was discussed.
Limitations of Structural Allograft in Revision Total Knee Arthroplasty

Management of large bone defects in total knee arthroplasty (TKA) usually has involved modular prostheses with metal augments, structural allografts, and megaprostheses. We retrospectively reviewed the outcome of treatment of major bone defects for 74 patients (79 knees) who had revision TKAs with structural allografts; nine patients were lost to followup before 5 years, leaving 65 patients (70 knees, or 88%) followed for a minimum of 5 years or until revision or death. Medical records, radiographs, patient surveys, and correspondence were used for all data. Sixteen patients (22.8%) had failed reconstructions and underwent additional revision surgery; eight of the 16 were secondary to allograft failure, three were secondary to failure of a component not supported by allograft, and five were secondary to infection. In patients not requiring revision surgery, the Knee Society score improved from 49 preoperatively to 87 postoperatively. We observed revision-free survival of 80.7% (95% confidence interval, 71.7–90.8) at 5 years and 75.9% (95% confidence interval, 65.6–87.8) at 10 years. Our data support the selective use of structural allograft for large cavitary defects encountered during TKA. However, the rates of complications and reoperations suggest efforts to improve results or develop more durable alternative methods are warranted for these challenging reconstructions. Level of Evidence: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
Modelling the AFIT random noise radar

The ultrawideband, random, continuous waveform generated by the Air Force Institute of Technology (AFIT) random noise radar (RNR) results in a sensing capability that is electromagnetically compatible with other radio frequency systems and has a low probability of intercept. The RNR, originally designed for through-the-wall imaging, has the distinct sensor characteristics required for collision avoidance in an autonomous vehicle. However, the hardware has not been designed for such an application. To facilitate trade-off analyses, a software model has been developed, emulating system performance and allowing the radar engineer to predict performance changes resulting from hardware modifications. This paper presents the software model construct of the AFIT RNR and provides a comparison between the simulated and measured results. (6 pages)
Relationships and Unethical Behavior: A Social Network Perspective

Recent models of unethical behavior have begun to examine the combination of characteristics of individuals, issues, and organizations. We extend this examination by addressing a largely ignored perspective that focuses on the relationships among actors. Drawing on social network analysis, we generate propositions concerning types of relationships (strength, multiplexity, asymmetry, and status) and the structure of relationships (structural holes, centrality, and density). We also consider the combination of the type and structure of relationships and how this embeddedness perspective relates to social contagion and conspiracies.
Lymphocyte‐depleted Hodgkin's disease: Diagnostic challenges by fine‐needle aspiration

The diagnosis of Hodgkin's disease by fine-needle aspiration (FNA) can be problematic. A case of Hodgkin's disease, lymphocyte depleted subtype, sample by FNA biopsy is presented. We describe the cytomorphologic features present in this unusual subtype of Hodgkin's disease and discuss the differential diagnosis. Immunohistochemical and morphologic findings of a subsequent biopsy specimen supported the diagnosis. Although FNA is an increasingly used diagnostic modality to evaluate tumors including malignant lymphomas, Hodgkin's disease remains, as in this case, a difficult diagnosis by FNA.
A modified cognitive-behavioral approach to group therapy with the elderly

Group approaches to treatment subsume a wide variety of techniques. The present article describes a modified cognitive behavioral approach as developed by the author for certain groups of elderly clients. This modified approach incorporates principles of cognitive behavioral therapy in combination with humanistic, and developmental perspectives, while leaving room for addressing psychodynamic issues if desired. It is suggested that such an approach is of value where structured group techniques are called for.
Team for volcano mission

NASA and a university research team are joining forces this month to mount what could become one of the most significant research missions ever undertaken to understand how volcanos affect the earth's atmosphere, weather, and climate, and their target is Mount St. Helens. The mission will use a NASA applications satellite, an aircraft crammed with the latest in laser and electronic remote—and near-sensing technologies, and the expertise of scientists from two NASA centers—Langley Research Center, Hampton, Virginia, and Wallops Island Flight Center, Wallops Island, Virginia. The university research team will have investigators from Drexel University in Philadelphia; the Universities of Maryland, Arizona, and Alaska; Dartmouth College, Hanover, New Hampshire; Michigan Technological University, Houghton; and the Oregon Graduate Center.
Advances in dehydration of foods

Food dehydration is still one of the most relevant and challenging unit operations in food processing, although the art of food preservation through the partial removal of water content dates back several centuries. This article provides essential information on the fundamental, including psychrometry, and applied engineering aspects of food dehydration with up-to-date available commercial applications. The evolution of drying technology, divided into four generations, is thoroughly reviewed, from tray drying to the combination of some drying technologies (the hurdle technology approach in drying) in order to optimize the process in terms of final food quality and energy consumption. The study of each generation covered numerous examples of different dryers, including their principles of operation, basic configurations and most common applications, as well as their main advantages and disadvantages.
Identification of a novel intertypic recombinant species D human adenovirus in a pediatric stem cell transplant recipient.

Background Human adenoviruses (HAdV) are known opportunistic pathogens in hematopoietic stem cell transplant (SCT) recipients. The detection of HAdV infection in children after SCT has been implicated as a determinant of poor outcome but specific associations between HAdV species or individual HAdV types and disease are poorly understood.
Steady-State Analysis of Phase-Locked Loops Using Binary Phase Detector

Phase-locked loops (PLLs) using binary phase detectors (BPDs) are modeled and analyzed in this paper. Steady-state behavior for PLLs based on BPDs (BPLs) using first- and second- order loop filters is characterized using transient waveform equations. It is shown that BPLL has a range of oscillation modes in steady state when there is no input jitter. The BPLL is most likely to operate at the most stable oscillation mode (MSOM) under the disturbance of random input jitter. The MSOM is determined by evaluating the relative stability of all the modes. The expected value of the output jitter amplitude is derived and its dependence on the loop parameters is analyzed.
RNase P in Research and Therapy

Fooling the catalytic RNA subunit into recognizing nonnatural substrates may have important implications for biotech
The influence of inorganic phosphate on photosynthesis in intact chloroplasts from Mesembryanthemum crystallinum L. plants exhibiting C3 photosynthesis or crassulacean acid metabolism.

Intact chloroplasts were obtained from mesophyll protoplasts isolated from Mesembryanthemum crystallinum in the C3 or Crassulacean acid metabolism (CAM) photosynthetic mode, and examined for the influence of inorganic phosphate (Pi) on aspects of bicarbonate-dependent O2 evolution and CO2 fixation. While the chloroplasts from both modes responded similarly to varying Pi, some features appear typical of chloroplasts from species capable of CAM, including a relatively high capacity for photosynthesis in the absence of Pi, a short induction period, and resistance to inhibition of photosynthesis by high levels of Pi. In the absence of Pi the chloroplasts retained 75–85% of the 14CO2 fixed and the total export of dihydroxyacetone phosphate was low compared with the rate of photosynthesis. In CAM plants the ability to conduct photosynthesis and retain most of the fixed carbon in the chloroplasts at low external Pi concentrations may enable storage of carbohydrates which are essential for providing a carbon source for the nocturnal synthesis of malic acid. At high external Pi concentrations (e.g. 10 25 mM), the amount of total dihydroxyacetone phosphate exported to the assay medium relative to the rate of photosynthesis was high while the products of 14CO2 fixation were largely retained in the chloroplasts which indicates starch degradation is occurring at high Pi levels. Starch degradation normally occurs in CAM plants in the dark; high levels of Pi may induce starch degradation in the light which has the effect of limiting export of the immediate products of photosynthesis and thus the degree of Pi inhibition of photosynthesis with the isolated chloroplast.
U.S.-Listed Foreign Companies' Choice of a U.S.-Based versus Home Country-Based Big N Principal Auditor and the Effect on Audit Fees and Earnings Quality

SYNOPSIS: We examine why U.S.-listed foreign companies choose to have a U.S.-based (rather than home country-based) Big N firm as their principal auditor for SEC reporting purposes and the effects...
Reactions of Laser-Ablated Osmium and Ruthenium Atoms with Nitric Oxide in Neon and Argon. Matrix Infrared Spectra and Density Functional Calculations of Os(NO)1-3, Ru(NO)1-3, NOsO, NRuO, OsNO+ and RuNO+

Laser-ablated osmium and ruthenium are reacted with nitric oxide and the products are isolated in solid neon and argon. The primary products in both neon and argon are the nitrosyl complexes M(NO)1-3. Sharp, weak bands due to the mononitrosyl cations are also observed. The insertion products NMO observed for both metals differ in their stability relative to MNO; NOsO is more stable than OsNO whereas the reverse is the case for RuNO and NRuO. Density functional theory (DFT) calculations effectively reproduce the experimental observations and predict frequencies of chemically useful accuracy. The calculated isotopic ratios are also in very good agreement with experiment, showing that DFT correctly describes the normal modes in these molecules.
Posttraumatic stress disorder: Characteristics and pharmacological response in the veteran population

Abstract A retrospective chart review was conducted on all patients with the primary diagnosis of posttraumatic stress disorder (PTSD) admitted over a one-year period to a Veterans Administration Medical Center. The data base consisted of 14 Vietnam veterans and one World War II veteran. The purpose of the review was to compare the symptom profile of combat veterans to the established DSM III criteria for PTSD and to evaluate the efficacy of pharmacotherapy. The veterans' symptomatology was much more complex than described in DSM III and the currently employed drug therapy appears to be generally inadequate in treating combat-related PTSD.
Pseudo-Meigs' syndrome associated with malignant struma ovarii: a case report.

Abstract Background . Malignant struma ovarii is a rare tumor, consisting of a struma ovarii with malignant transformation. The association of a malignant struma ovarii with pseudo-Meigs' syndrome and elevated Ca-125 levels has been never reported. Case . A 66-year-old woman presented with monolateral ovarian mass, ascites, hydrothorax, and elevated Ca-125 levels. Optimal medical staging was performed. Definitive histological examination revealed a malignant struma ovarii. The immediate and complete resolution of symptoms and rapid decline of both Ca-125 and thyroglobulin levels to normal value were achieved post-operatively. After counseling, strict follow-up was planned, and no adjuvant therapy was administered. Conclusion . We report the first case of pseudo-Meigs' syndrome associated with malignant struma ovarii and elevated Ca-125 levels. The choice of not performing adjuvant therapy is feasible after optimal surgery and adequate staging procedure given to the usually clinical benign course and the low incidence of metastases in malignant struma ovarii. Careful patient counseling is required.
Origin and Evolution of the Diatomyidae, with Clues to Paleoecology from the Fossil Record

Abstract The Diatomyidae (Rodentia, Mammalia) are a group of medium to large rodents restricted to southern and eastern Asia. The skull, characterized by hystricomorphous musculature, a 4/4 cheek tooth formula, a sciurognathous jaw, and other features, places the Diatomyidae in a phylogenetic position near, but not within, Hystricognathi. Like living Ctenodactylidae, they are a product of the early radiation of Rodentia that includes, ultimately, the hystricognaths. The oldest fossil Diatomyidae occur in Oligocene terrestrial sediments of the Indian subcontinent. Younger sediments in Pakistan near the Oligocene/Miocene boundary produce a quite different diatomyid that presents unique, derived conditions, and demonstrates early diversification of the family. This diatomyid, described here as Marymus dalanae, new genus and species, has cuspate anterior cheek tooth morphology interpreted as specialized, possibly for predation on invertebrates. All early diatomyids are relatively abundant components of their ...
Brain Natriuretic Peptide and Cardiac Resynchronization Therapy in Patients With Mildly Symptomatic Heart Failure

Background— There are limited data on the prognostic implications of brain natriuretic peptide (BNP) assessment in patients with mildly symptomatic heart failure (HF) who receive cardiac resynchronization therapy with a defibrillator (CRT-D). Methods and Results— The effect of elevated baseline and 1-year BNP levels (dichotomized at the upper tertile BNP of 120 pg/mL) on the risk of HF or death was assessed among the cohort of 1197 patients with baseline BNP data enrolled in MADIT (Multicenter Automated Defibrillator Implantation Trial)-CRT. Elevated baseline BNP was associated with a significant 68% ( P =0.007) and 58% ( P =0.02) increase in the risk of HF or death among MADIT-CRT patients allocated to CRT-D and implantable cardioverter defibrillator-only therapy, respectively. At 1 year of follow-up, patients allocated to CRT-D displayed significantly greater reductions in BNP (26% reduction) levels compared with implantable cardioverter defibrillator-only patients (8% increase; P =0.005). Patients with CRT-D in whom 1-year BNP levels were reduced or remained low experienced a significantly lower risk of subsequent HF or death as compared with patients in whom 1-year BNP levels were high. Similarly, the echocardiographic response to CRT-D was highest among those who maintained low BNP levels or in whom BNP level at 1-year was reduced. Conclusions— Our findings suggest that assessment of baseline and follow-up BNP provides important prognostic implications in patients with mildly symptomatic HF who receive CRT. Clinical Trial Registration— URL: . Unique identifier: [NCT00180271][1]. [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00180271&atom=%2Fcirchf%2F6%2F5%2F998.atom
Per capita community-level effects of an invasive grass, Microstegium vimineum, on vegetation in mesic forests in northern Mississippi (USA)

Quantifying per capita impacts of invasive species on resident communities requires integrating regression analyses with experiments under natural conditions. Using multivariate and univariate approaches, I regressed the abundance of 105 resident species of groundcover plants and tree seedlings against the abundance and height of an invasive grass, Microstegium vimineum, within 117 plots in four mesic floodplain forests in Mississippi (USA). Microstegium vimineum was most productive (i.e., tallest and most abundant) in canopy gaps in floodplains, and a significant amount of variation in resident species composition was directly explained by canopy gaps and stand age. The relatively small (but statistically significant) percentage of variation in resident species composition (1.8%) explained by M. vimineum in the multivariate analysis was attributable to significant relationships with a few common species. Most of these were negative relationships with shady mesic forest indicators. Most positive relationships were with infrequent disturbance indicators and with species with growth phenologies that differed from that of M. vimineum. Results of field competition experiments with the three most common species to show significant relationships with M. vimineum revealed asymmetric competitive effects of M. vimineum on Chasmanthium laxum and positive responses of Quercus alba seedlings and Leersia virginica adults to the removal of M. vimineum in one growing season. Results of this study suggest that negative per capita community-level effects of M. vimineum are likely to be greater in shady forests than in open floodplain forests due to the relative paucity of vulnerable species in the latter.
The impact of social groups on the capacity of wireless networks

The capacity of a wireless network with n nodes is studied when nodes communicate with one another in the context of social groups. Each node is assumed to have at least one local contact in each of the four directions of the plane in which the wireless network operates, and q(n) independent long-range social contacts forming its social group, one of which it selects randomly as its destination. The distance between source and the members of its social group follows a power-law distribution with parameter α, and communication between any two nodes takes place only within the physical transmission range; hence, source-destination communication takes place over multi-hop paths. The order capacity of such a composite network is derived as a function of the number of nodes (n), the social-group concentration (α), and the size of social groups (q(n)). It is shown that the maximum order capacity is attained when α ≥ 3, which makes social groups localized geographically, and that a wireless network can be scale-free when social groups are localized and independent of the number of nodes in the network, i.e., q(n) is independent of n.
Noise selection approach to image restoration

This paper deals with a restoration (both denoising and deblurring) method. For instance in the case of denoising, this latter is only a small modification from the usual wavelet thresholding. However, it has the significant advantage to allow the use of several bases in such a way that we select what is considered as information by a basis or another basis or another basis, and so on for as many bases as we want. The computational cost of the method is mainly the computation of the coordinates of the signal (or image) in the bases.© (2001) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
The Effects of Outpatient Geriatric Evaluation and Management on Caregiver Burden

This study investigated the effects of outpatient geriatric evaluation and management (GEM) on informal caregivers' sense of burden. We randomized 568 high-risk, community-dwelling older adults to receive either GEM or usual care for 6 months. At baseline and one year later, we assessed the burden experienced by their informal caregivers (N = 88). Compared with caregivers of participants in the usual care group, caregivers of participants in the GEM group were less than half as likely to report increased burden during the one-year follow-up period (16.7% vs 38.5%, p = .034). The findings suggest that GEM helps protect the informal caregivers of high-risk older people from the increases in burden that often accompany advancing age.
Tunable all-optical wavelength conversion and wavelength multicasting using orthogonally-polarized fiber FWM

We demonstrate novel tunable all-optical wavelength conversion and wavelength multicasting using orthogonally-polarized fiber FWM in highly-nonlinear fiber. Less then 0.5 dB power penalty with >25 nm tuning range 3-to-3-multicasting is shown for a 10 Gb/s NRZ system.
The NLC positron source

A baseline design for the NLC positron source based on the existing SLC positron system is described. The proposed NLC source consists of a dedicated S-band electron accelerator, a conventional positron production and capture system utilizing a high-Z target and an adiabatic matching device, and an L-band positron linac. The invariant transverse acceptance of the capture system is 0.06 m/spl middot/rad, ensuring an adequate positron beam intensity for the NLC.
Untreated Type 2 Diabetes and Its Complications Are Associated With Subcortical Infarctions

Abstract Objective – To investigate the association of type 2 diabetes with subcortical infarctions. Research design and methods – We investigated the association in subjects with type 2 diabetes (cases; n = 93) and without type 2 diabetes (controls; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging. Results – The frequency of subcortical infarctions was 39% in cases and 29% in controls (odds ratio [OR] 1.59; 95% confidence interval [CI] 0.91–2.75). The association was stronger in cases without treatment (OR 2.60; 95% CI 1.11–6.08) and in cases with diabetes-related complications (OR 1.96; 95% CI 1.02–3.74) compared to controls. Conclusions – These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.
Doppler component analysis of the suburban vehicle-to-vehicle DSRC propagation channel at 5.9 GHz

This study presents Doppler component analysis of the mobile vehicle-to-vehicle propagation channel at 5.9 GHz. The measurements were conducted via a VANET field implementation under realistic suburban driving conditions in Pittsburgh, Pennsylvania. Different components in the observed spectrum were analyzed with vehicle speeds and compared with theoretical mobile-to-mobile scenarios. Intuitive understandings are also provided based on our analysis from on-road measurements.
Criterion A, Peritraumatic Emotions, and Posttraumatic Stress Disorder

The present study partially replicates and then expands on the work of Boals and Schuettler (2009) by evaluating the relationship between Criterion A, peritraumatic emotions, and posttraumatic stre...
Specific Resistance of Body Tissues

The resistive properties of various tissues surrounding the heart were investigated in a number of living dogs. Alternating currents of a frequency varying between 10 and 10,000 c.p.s. have been used for this purpose. Technical problems associated with such measurements are analyzed. The results show that the resistive properties of most tissues are comparable and that the resistivity decreases slowly as the frequency increases.
Performance of hybrid methods for large-scale unconstrained optimization as applied to models of proteins.

Energy minimization plays an important role in structure determination and analysis of proteins, peptides, and other organic molecules; therefore, development of efficient minimization algorithms is important. Recently, Morales and Nocedal developed hybrid methods for large-scale unconstrained optimization that interlace iterations of the limited-memory BFGS method (L-BFGS) and the Hessian-free Newton method (Computat Opt Appl 2002, 21, 143-154). We test the performance of this approach as compared to those of the L-BFGS algorithm of Liu and Nocedal and the truncated Newton (TN) with automatic preconditioner of Nash, as applied to the protein bovine pancreatic trypsin inhibitor (BPTI) and a loop of the protein ribonuclease A. These systems are described by the all-atom AMBER force field with a dielectric constant 1 and a distance-dependent dielectric function 2r, where r is the distance between two atoms. It is shown that for the optimal parameters the hybrid approach is typically two times more efficient in terms of CPU time and function/gradient calculations than the two other methods. The advantage of the hybrid approach increases as the electrostatic interactions become stronger, that is, in going from 2r to 1, which leads to a more rugged and probably more nonlinear potential energy surface. However, no general rule that defines the optimal parameters has been found and their determination requires a relatively large number of trial-and-error calculations for each problem.
Electron-microscopic analysis of synaptic input from the perigeniculate nucleus to the A-laminae of the lateral geniculate nucleus in cats.

The perigeniculate nucleus of carnivores is thought to be a part of the thalamic reticular nucleus related to visual centers of the thalamus. Physiological studies show that perigeniculate neurons, which are primarily GABAergic, provide feedback inhibition onto neurons in the lateral geniculate nucleus. However, little is known about the anatomical organization of this feedback pathway. To address this, we used two complementary tracing methods to label perigeniculate axons for electron microscopic study in the geniculate A-laminae: intracellular injection of horseradish peroxidase (HRP) to fill an individual perigeniculate cell and its axon; and anterograde transport of Phaseolus vulgaris leucoagglutinin to label a population of perigeniculate axons. Labeled perigeniculate terminals display features of F1 terminals in the geniculate neuropil: they are small, contain dark mitochondria, and form symmetric synaptic contacts. We found that most of the perigeniculate terminals (greater than 90%) contact geniculate cell dendrites in regions that also receive a rich innervation from terminals deriving from visual cortex (e.g., "cortico-recipient" dendrites). The remainder of the perigeniculate synapses (10%) contacted dendrites in regions that also received direct retinal input (e.g., "retino-recipient" dendrites). Serial reconstruction of segments of dendrites postsynaptic to perigeniculate terminals suggests that these terminals contact both classes of relay cell in the A-laminae (X and Y), although our preliminary conclusion is that an individual perigeniculate cell contacts only one class. Finally, our quantitative comparison between labeled perigeniculate terminals and unlabeled F1 terminals indicates that these perigeniculate terminals form a distinct subset of F1 terminals. We quantitatively compared the labeled perigeniculate terminals to unlabeled F1 terminals. Although the parameters of the perigeniculate terminals fell entirely within the range of those for the unlabeled F1 terminals, as populations, we found consistent differences between these two groups. We thus conclude that, as populations, other sources of F1 terminals are morphologically distinct from perigeniculate terminals and innervate different targets.
INTRADAY CHANGES IN TARGET FIRMS' SHARE PRICE AND BID‐ASK QUOTES AROUND TAKEOVER ANNOUNCEMENTS

This paper documents changes in share prices, bid-ask spreads, and quote sizes for target firms during the day a takeover proposal is announced. The mean 21.2 percent announcement-day return consists primarily of a 19.5 percent return at the announcement. There is little evidence that spreads increase before the announcement, except when trading is suspended because of an order imbalance. Quote sizes show some sign of decreasing just before the announcement. The quoted bid-ask spread and size increase immediately after the announcement, but spreads quickly return to normal.
The Sublime as a Source of Light in the Works of Nicolas Boileau

Nicolas Despreaux, better known as Boileau is by far the greatest rhetorician France has ever produced. Like his Greek and Latin predecessors, Aristotle and Horace, he managed to impose on his contemporaries the aesthetic rules that he believed should be applied to every genre that existed in literature. In his Art Poetique (1674) which is itself a perfect model of how poetry should be composed, Boileau imposed himself as a critic of infallible taste. He did not hesitate to condemn the works of writers who used pompous and extravagant language such as the members of the “precious” school of thought. At the same time he had the taste and the sensitivity which enabled him to recognize the genius of such great authors as Corneille, Moliere, La Fontaine and Racine. More than three hundred years after he died, Boileau is still admired today as a man of impeccable taste. Except for scholars who specialize in 17th century French literature, the authors he condemned for their poor artistic achievements are totally unknown today but those he lavished with praise are still beloved in France and throughout the world.
Computational drug repositioning based on side-effects mined from social media

Drug repositioning methods attempt to identify novel therapeutic indications for marketed drugs. Strategies include the use of side-effects to assign new disease indications, based on the premise that both therapeutic effects and side-effects are measurable physiological changes resulting from drug intervention. Drugs with similar side-effects might share a common mechanism of action linking side-effects with disease treatment, or may serve as a treatment by “rescuing” a disease phenotype on the basis of their side-effects; therefore it may be possible to infer new indications based on the similarity of side-effect profiles. While existing methods leverage side-effect data from clinical studies and drug labels, evidence suggests this information is often incomplete due to under-reporting. Here, we describe a novel computational method that uses side-effect data mined from social media to generate a sparse undirected graphical model using inverse covariance estimation with l1-norm regularization. Results show that known indications are well recovered while current trial indications can also be identified, suggesting that sparse graphical models generated using side-effect data mined from social media may be useful for computational drug repositioning. Subjects Bioinformatics, Data Mining and Machine Learning, Computational Biology, Social Computing
Serine and Aspartic Acid Metabolism in Leukemic Leukocytes: Correlation to Effectiveness of Therapy

Leukocytes from patients with acute granulocytic leukemia (AGL), acute monocytic leukemia (AMoL) and blastic crisis of chronic granulocytic leukemia (BC) were incubated with serine-U-C14 or aspartic acid-U-C14. The metabolism was followed by determination of radioactivity of CO2, lipids, proteins, organic acids, and nucleotides. Leukemic leukocytes in AGL, AMoL, and BC exhibit high serine utilization compared to lymphocytic leukemias. Significant changes in the metabolic pattern of the leukocytes from patients with chronic granulocytic leukemia (CGL) preceded the onset of blastic crisis. Serine utilization remained abnormal in two patients with AGL after complete remission was achieved. Low conversion of serine to CO2 in AMoL was associated with achievement of complete remission and long survival time. Aspartic acid was most actively metabolized by leukemic cells in BC. The results of these studies indicate that the metabolic pattern of serine and aspartic acid varies with the type of leukemic cell. There is evidence that mature polymorphonuclear (PMN) leukocytes in the blood of leukemic patients may possess an abnormal metabolism.
Adversarial Feature Selection

This work introduces adversarial feature selection, a game between a feature selection agent and its adversary. The adversarial approach is drawn from existing work on adversarial classification. The feature selection algorithm selects a subset of features from the original set based on their utility towards classification accuracy. A cost is incurred based on features selected. The adversary modifies features with less utility as ones with higher utility. In this way, the adversary profits if the feature selector selects these features at increased costs. A base feature selection algorithm is used to generate cost values for features. The problem is formalized and a corresponding model of the algorithm is discussed and evaluated.
Self-emission glucose monitoring system with single chip guided-mode resonance filters

In this study, we designed and simulated an array of bandpass filters as a spectral separator for mid-infrared self-emission noninvasive glucose monitoring, using the human body as the background radiation emitter. The filters were based on the guided-mode resonance (GMR) effect. The human body is a good black body radiator that provides a stable temperature and continuous radiation energy in the mid-infrared range. We can thus use self-emission from the human body to measure certain fingerprint peaks of glucose spectrum between 8 μm to 10 μm, which allows estimation of glucose concentration. The GMR filter set includes at least four filters on one chip fabricated at the same time. By using fixed thicknesses and the same thin-film material for all the filters on the chip, a structure period adjustment alone can theoretically achieve multiple bandpass filters between the glucose fingerprint ranges - and achieve these coplanar filters on a single chip. By using all CMOS-compatible materials, COMSOL simulations show that a series of peaks with transmittances up to 70% and bandwidths of around 200nm can be achieved. This filter set can be fabricated with just a few thin layers that can simplify the typical thin-film deposition process. The proposed GMR filter array can then be combined with a thermometer array to achieve the non-invasive glucose monitoring. We compare the results obtained with the first version of the fabricated filter set with the measurements of Fourier transform infrared (FT-IR) spectroscopy.
White light triangulation sensor for flexible inspection system

A triangulation sensor containing two light sources with different wavelength and individual slit has been developed. Differential technique is applied to improve spatial resolution as performing height reconstruction of a specimen. The system can measure up to 7 mm with accuracy up to 1.144 um. Robotic arm with multiple degrees of freedom can be employed as the motion platform to increase flexibility of inspection.
Full waveform based microseismic source mechanism studies in the Barnett shale using dual array data

Summary Microseismic source mechanisms have potential value for understanding the reservoir, natural fractures, stress state, and fracturing mechanisms. In its general form, the microseismic source model is represented by a symmetric moment tensor having six independent components. Difficulties arise when attempting to invert for the complete moment tensor from a single well dataset. In this paper, a full-waveform inversion approach for inverting the complete moment tensor is discussed using a dual-array dataset from a hydraulic fracturing stimulation in the Barnett shale at Fort Worth Basin. The primary information derived consists of the fault-plane solution (i.e. strike, dip and rake), the slip direction, and the seismic moment. The derived source mechanisms are compared with previous fracture studies in the same field. The results are provided to demonstrate that the full waveform based complete moment tensor inversion can be used to extract useful microseismic source information to further understand the reservoir and the fracturing process.
Book Review of Thomas O. Mcgarity, Freedom to Harm: The Lasting Legacy of the Laissez-Faire Revival

This article reviews Thomas O. McGarity’s book, Freedom to Harm: The Lasting Legacy of the Laissez-Faire Revival (Yale University Press, 2013). McGarity’s work describes an aggressive 30 year effort by conservative academics, wealthy right-wing funders, conservative think tanks and anti-government “public interest groups” to undermine or eliminate governmental institutions and laws designed to curb recklessly irresponsible business practices. It also offers suggestions for striking a new social bargain that will undo the damage done to American regulatory and civil justice systems by what McGarity refers to as the laissez faire revival. This review summarizes key aspects of McGarity’s work and critiques his findings and prescriptions.
Study of NKA-9 Resin Adsorption to Bilirubinic in Hematoplasma and Biocompatibility

NKA-9 resin adsorption effect to hematoplasma bilirubin and biocompatibility were investigated.Hematoplasma of serious Icteric disease aegers were perfused by exchanging transfusion in the packed NKA-9 resin under quiet state and perfusion state.Better adsorption time and the number of adsorption columns used to treat Icterus neonatorum disease were ascertained after detecting the adsorption rate at different time and different bilirubinic concentration,respectively.Three level perpendicular experiments were designed under the conditions of the diameter of adsorption column,the flow rate of perfusion and the temperature,better adsorption conditions were explored.Finally the change quantities of the other ingredients of hematoplasma were detected and the biocompatibility experiment was done.The results show that the adsorption rate of NKA-9 resin to bilirubin under quiet state and perfusion state are 36%~45%and 70%~90%,respectively.The better adsorbing time is 40 min,the ratio of diameter and volume of adsorption column is 0.20~2 cm,the flow rate of perfusion is 100.56 cm/h,temperature is 25℃.The adsorption rate of NKA-9 to Bilirubin in hematoplasma is close to 95% under better conditions.NKA-9 resin has high adsorption rate to bilirubin and better blood compatibility and biocompatibility,which indicated that it could be as absorbent for treating Icterus neonatorum disease by clinical hemoperfusion.
Pathogenic identification and genotype analysis of an hand-foot-mouth disease epidemic caused by coxsackievirus B4

Objective:To identify the pathogen that caused the outbreak of HFMD epidemic,and to find out the genetic character of the pathogen.Methods: After pan-enterovirus PCR primers positive-detected but EV71 and CoxA16 negative-detected specimens were screened by Real-time PCR kit,ten positive specimens were subject to two-step RT-PCR using our designed long range PCR universal primers.After sequencing of the PCR products,the sequence homology search was done on GenBank to determine which serotype they belong,and further the molecular phylogeny tree was constructed to determine which genotype the enterovirus belong.Results: 19 of the total 34 specimens were pan-enterovirus positive-detected but EV71 and CoxA16 negative-detected by realtime PCR.The 10 positive specimens were subject to VP1 sequencing,and classified to coxsackievirus B4 by homology search.And the phylogeny analysis with other coxsackievirus B4 indicated that the isolated coxsackievirus B4 should be classified to the VIII genotype of Coxsackievirus B4.Conclusion: The pathogen of this epidemic of Hand-Foot-Mouth Disease were determined as the VIII genotype of Coxsackievirus B4.
Ecotoxicological effects of artificial smokes on a terrestrial microcosm.

Single-Species-Tests do not allow assessment of environmental effects on an entire ecosystem since ecosystems have properties which indicate that the whole system is greater than the sum of its parts. Monitoring the effects of stressors should include the aspects of structure and function, e.g. the composition of the biological community, the quantiy and distribution of abiotic materials, biological energy flow and biogeochemical cycles (Giesy and Odum 1980).
Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe

Analysis of complex mixtures of proteins by hydrogen exchange (HX) mass spectrometry (MS) is limited by one’s ability to resolve the protein(s) of interest from the proteins that are not of interest. One strategy for overcoming this problem is to tag the target protein(s) to allow for rapid removal from the mixture for subsequent analysis. Here we illustrate a new solution involving fluorous conjugation of a retrievable probe. The appended fluorous tag allows for facile immobilization on a fluorous surface. When a target protein is passed over the immobilized probe molecule, it can be efficiently captured and then exposed to a flowing stream of deuterated buffer for hydrogen exchange. The utility of this method is illustrated for a model system of the Elongin BC protein complex bound to a peptide from HIV Vif. Efficient capture is demonstrated, and deuteration when immobilized was identical to deuteration in conventional solution-phase hydrogen exchange MS. Protein captured from a crude bacterial cell lys...
Formal Total Synthesis of Echinopines A and B via Cr(0)-Promoted [6π + 2π] Cycloaddition

A concise formal synthesis of echinopines A and B is reported. The key [5.5.7] tricyclic intermediate, which has been previously used for the synthesis of echinopine A and B, was assembled using Cr(0)-promoted photochemical [6π + 2π] cycloaddition followed by a radical cyclization step.
The clinical interview

This chapter describes the major phases of the clinical interview conducted during neuropsychological evaluation, which include introducing the purpose and nature of the evaluation to the patient and establishing initial rapport; obtaining the history of concerns that motivated the evaluation; reviewing the patient's medical, educational, social, and family history; and concluding the interview and transitioning to formal testing. Establishing rapport with patients is critical for increasing the likelihood that they will benefit from any psychological service, either assessment or psychotherapy. This is particularly important in the neuropsychological evaluation of older individuals, many of whom have significant anxiety about developing debilitating neurodegenerative disorders or may be resistant to evaluation because they have felt pressured into receiving evaluation. The review of the background records is the initial step in gathering information about the patient's concerns and those of the family, and these records may provide a rich source of information and form the basis of initial hypotheses concerning the source of the patient's difficulties. After the patient and family have expressed their concerns, a more structured interview is conducted to check on a wider range of possible symptoms and to obtain a more detailed history. After the inquiry concerning behavioral changes, the patient's medical, educational, occupational, and family history are reviewed. This review provides a more general context within which the meaning and etiology of the behavioral changes can be understood and interpreted.
CoFeRh alloys: Part 1. Electrodeposition of Rh and nonmagnetic CoFeRh alloy

Abstract The electrochemical behavior of Rh(III) species in CoFe solution containing RhCl 3 , NH 4 Cl, H 3 BO 3 , CoSO 4 , FeSO 4 , saccharin, and NaLS (Na lauryl sulfate) has been investigated. The electrochemistry of Rh(III) species is influenced by each of the compounds present in CoFe plating solution, but especially by addition of saccharin and H 3 BO 3 to the RhCl 3 -NH 4 Cl solution. The nucleation and growth of Rh on GC (glassy carbon), Ru, and Cu electrodes from NH 4 Cl solution was studied using the potentiostatic current-transient methods. The results support a predominantly progressive nucleation of Rh on all three-electrode surfaces. The nucleation kinetic parameters ANo (steady state nucleation rate) and Ns (saturation nuclear number density) were found to vary with potential and are electrode-dependent in order: GC > Ru∼Cu. The electrodeposited Rh films obtained from NH 4 Cl solution and nonmagnetic CoFeRh film obtained from CoFe solution were characterized in terms of the following properties: morphology, surface roughness, crystal structure and chemical composition. The origin of light elements found in Rh and CoFeRh films (O, Cl, S, C, N) was discussed.
Mu2e Transport Solenoid Cold-Mass Alignment Issues

The muon-to-electron conversion experiment (Mu2e) at Fermilab is designed to explore charged lepton flavor violation. It is composed of three large superconducting solenoids: the production solenoid, the transport solenoid (TS), and the detector solenoid. The TS is formed by two magnets: TS upstream and TS downstream. Each has its own cryostat and power supply. Tolerance sensitivity studies of the position and angular alignment of each coil in this magnet system were performed in the past with the objective to demonstrate that the magnet design meets all the field requirements. The alignment of the cold masses is critical to maximize the transmission of muons and to avoid possible backgrounds that would reduce the sensitivity of the experiment. Each TS magnet cold mass can be individually aligned. In this paper, we discuss the implications of the alignment of the TS cold masses in terms of the displacement of the magnetic center. Consideration of the practical mechanical limits is also presented.
Faculty–library collaborations in digital history: A case study of the travel journal of Cornelius B. Gold

In this article, the authors present a case study on a teaching and learning initiative in digital humanities at Connecticut College. The article outlines a project in which students in a midlevel ...