cssi/SciSciGPT-SciSciNet huggingface dataset:
A Calm and Happy Keeper of the Keys: The Impact of ACA Views, Relations With Coworkers, and Policy Views on the Job Stress and Job Satisfaction of Correctional Staff

Job stress and job satisfaction have both received a considerable amount of attention among studies of organizations in general, and correctional organizations are no exception. Although many work-related factors have been used to explain these two concepts, several important areas have been excluded. The current study builds on existing research by examining job stress and job satisfaction and how they are affected by American Correctional Association (ACA) standards, relations with coworkers, and prison policies. Using survey data collected from a large county correctional system in Orlando, Florida, the findings suggest that ACA views, relations with coworkers, and institutional policies all have significant effects on job stress and satisfaction of correctional staff. The authors also find that these three work environment variables have a far greater magnitude of effects than do the personal characteristics of employees.
Changes in Egg White During Incubation of the Fertile Egg

Abstract Fertile, Single Comb White Leghorn hatching eggs were obtained from the K.S.U. poultry farm and incubated at 37.8 ± 0.3° C. and 55–60% relative humidity. Eggs were taken from the incubator daily, candled to insure embryonic development, and quick frozen. The frozen eggs were sectioned and egg white collected carefully to avoid contamination with yolk material, embryonic tissue or blood. Albumen from incubated eggs was examined for changes in pH, free amino acid content, glucose, and sulfhydryl content. Albumen samples were subjected to polyacryamide gel electrophoresis and tested for lysozyme and conalbumin activity. Egg white from incubated eggs increased in free amino acids. Egg white pH at first increased, then decreased with incubation time. No change in sulfhydryl content was observed. Glucose content decreased rapidly after 3 days’ incubation. Electrophoretic analysis indicated severe alterations in egg white proteins during embryogenesis. Assays for lysozyme indicated a complete loss of enzymatic activity by the seventeenth day of incubation. Conalbumin, as determined by chromogenic iron-binding, decreased gradually and was nearly absent after seventeen days.
The Purdue Interest Questionnaire: helping engineering and technology students make career decisions

The authors focus on identifying and contrasting Purdue Interest Questionnaire (PIQ) interest patterns. Interests are identified and contrasted between parallel specialities within science, engineering, technology, and managerial areas. Helping students identify and understand their technical interests relative to career fields enables the individual to make more meaningful educational and career decisions. >
Induced anger as a reciprocal inhibitor of fear

Abstract The concept of ‘reciprocal inhibition’ underlies a growing number of clinical techniques used in removal of specific fears. This paper describes the successful treatment of fears using artificially induced anger as the counterconditioning agent. It has been found in a limited number of cases that once the artificial induction of anger has been taught it can become available for immediate use by the patient at any time and may be of sufficient strength to counteract a high degree of fear. Three illustrative cases are presented and problems encountered noted.
Recent Advances in the Management of Cryptococcal Meningitis in Patients with AIDS

The optimum regimen for the treatment of cryptococcal meningitis in patients with AIDS is still not totally clear. The triazoles fluconazole and itraconazole are associated with response rates of 50%-60%. Amphotericin B appears to be associated with a more rapid clearance of organisms, and there are some data suggesting that initial therapy with amphotericin B is preferable to that with triazoles; however, this finding has not been definitively shown in large comparative trials. Results of a recently completed large trial suggested that initial treatment with amphotericin B followed by triazole therapy is associated with an acute mortality rate (approximately 6%) that is substantially less than that in previous studies. Relapse is common (20%-60% of cases) if the patient does not receive chronic suppressive therapy. The drug of choice for maintenance therapy is fluconazole (200 mg/d). A recent trial showed that fluconazole was superior to itraconazole (200 mg/d) as suppressive therapy. Prophylactic use of fluconazole (200 mg/d) significantly decreases the incidence of cryptococcosis and mucosal candidiasis, especially in patients with CD4 cell counts of < 50/mm3. However, because of the lack of a survival benefit and the risk of the selection effect on fluconazole-resistant Candida, it is difficult to make the recommendation of routine prophylaxis with fluconazole for all patients with AIDS; the decision to use prophylaxis should be based on more selective criteria.
A Comparison of Communication Using the Apple iPad and a Picture-based System

Augmentative and alternative communication (AAC) interventions have been shown to improve both communication and social skills in children and youth with autism spectrum disorders and other developmental disabilities. AAC applications have become available for personal devices such as cell phones, MP3 Players, and personal computer tablets. It is critical that these new forms of AAC are explored and evaluated. The purpose of this study was to investigate the utility of the Apple iPad™ as a communication device by comparing its use to a communication system using picture cards. Five elementary students with autism spectrum disorders and developmental disabilities who used a picture card system participated in the study. The results were mixed; communication behaviors either increased when using the iPad or remained the same as when using picture cards. The implications of these findings are discussed.
The Act of Looking: Wofgang Iser's Literary Theory and Meaning Making in the Visual Arts

In his account about reading novels, Wolfgang Iser argued that the work of art is not the text itself but the experience that emerges as a reader interacts with the text. Yet, he clarified that the aesthetic object is not based only on the subjective input of the reader but also determined by specific signs that a text presents. This article draws from Iser's theories to examine the process through which five teenagers discover meaning in an abstract sculpture by artist Isamu Noguchi. The author shows how the young viewers arrived at a series of readings that were elicited by the qualities of the work and that built upon each other in a sort of snowballing process. The article also illustrates how the sort of meaning that an artwork can yield stretches throughout the whole experience and can therefore not be translated into a discursive statement.
Radiofrequency Ablation Followed by Conventional Radiotherapy for Medically Inoperable Stage I Non-small Cell Lung Cancer

Purpose The standard treatment of stage I non-small cell lung cancer (NSCLC) is surgical resection. Some patients are poor surgical candidates due to severe comorbid medical conditions. Radiotherapy alone has historically been used in this patient population with limited success. Radiofrequency ablation (RFA) is an image-guided, thermally mediated ablative technique recently applied to lung tumors. Combination therapy with both these treatments has not been previously performed. We report our experience with combined CT-guided RFA and conventional radiotherapy in 24 medically inoperable patients with a minimum of 2-year study follow-up in surviving patients. Patients and methods Twenty-four consecutive, medically inoperable patients with biopsy-proven, stage I NSCLC were treated with CT-guided RFA followed by radiotherapy to a dose of 66 Gy. RFA was performed with a single or cluster cool-tip F electrode; 21 patients were staged before therapy using fluorodeoxyglucose-positron emission tomography. Results There were 14 women and 10 men (median age, 76 years; range, 58 to 85 years). The histologic subtypes were squamous cell (n = 13), adenocarcinoma (n = 5), and undifferentiated (n = 6). All patients received RFA followed by three-dimensional conformal radiotherapy. There were no treatment-related deaths or grade 3/4 toxicities. Pneumothorax requiring chest tubes developed in three patients (12.5%). At a mean follow-up period of 26.7 months (range, 6 to 65 months), 14 patients (58.3%) died, with cumulative survival rates of 50% and 39% at the end of 2 years and 5 years, respectively. Ten of the deaths were cancer related. Two patients had local recurrence (8.3%), while nine patients had systemic metastatic disease. Three patients died of respiratory failure with no evidence of active disease, and one patient died of a cerebrovascular accident at 18-month follow-up. Pleural effusions developed after treatment in six patients (25%), which proved to be malignant in one patient. Conclusion RFA followed by conventional radiotherapy is feasible in this population of medically inoperable stage I NSCLC patients. Procedural complication rates are low, and no additional major toxicities were seen despite the addition of RFA. Local control and survival rates appear to be better than with radiotherapy alone.
Model-guided luminance range enhancement in mixed reality

Mixed Reality (MR) applications tend to focus on the accuracy of registration between the virtual and real objects of a scene, while paying relatively little attention to the representation of the luminance range in the merged video output. In this paper, we propose a means to partially address this deficiency by introducing Enhanced Dynamic Range Video, a technique based on differing brightness settings for each eye of a video see-through head mounted display (HMD). First, we construct a Video-Driven Time-Stamped Ball Cloud (VDTSBC), which serves as a guideline and a means to store temporal color information for stereo image registration. Second, with the assistance of the VDTSBC, we register each pair of stereo images, taking into account confounding issues of occlusion occurring within one eye but not the other. Finally, we apply luminance enhancement on the registered image pairs to generate an Enhanced Dynamic Range Video.
A unique role for the host ESCRT proteins in replication of Tomato bushy stunt virus.

Plus-stranded RNA viruses replicate in infected cells by assembling viral replicase complexes consisting of viral- and host-coded proteins. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host revealed the involvement of seven ESCRT (endosomal sorting complexes required for transport) proteins in viral replication. In this paper, we show that the expression of dominant negative Vps23p, Vps24p, Snf7p, and Vps4p ESCRT factors inhibited virus replication in the plant host, suggesting that tombusviruses co-opt selected ESCRT proteins for the assembly of the viral replicase complex. We also show that TBSV p33 replication protein interacts with Vps23p ESCRT-I and Bro1p accessory ESCRT factors. The interaction with p33 leads to the recruitment of Vps23p to the peroxisomes, the sites of TBSV replication. The viral replicase showed reduced activity and the minus-stranded viral RNA in the replicase became more accessible to ribonuclease when derived from vps23Δ or vps24Δ yeast, suggesting that the protection of the viral RNA is compromised within the replicase complex assembled in the absence of ESCRT proteins. The recruitment of ESCRT proteins is needed for the precise assembly of the replicase complex, which might help the virus evade recognition by the host defense surveillance system and/or prevent viral RNA destruction by the gene silencing machinery.
Incremental and Decremental Least Squares Support Vector Machine and Its Application to Drug Design

The least squares support vector machine (LS-SVM) has shown to exhibit excellent classification performance in many applications. In this paper, we propose an incremental and decremental LS-SVM based on updating and downdating the QR decomposition. It can efficiently compute the updated solution when data points are appended or removed. The experiment results illustrated that the proposed incremental algorithm efficiently produces the same solutions as those obtained by LS-SVM which recomputes the solution all over even for small changes in the data. For drug design, the results of each biochemistry laboratory test on a new compound can be iteratively included in the training set. This procedure can further improve precision in order to select the next best predicted organic compound. Instead of retraining entire data points, it is much efficient to update solution by incremental LS-SVM.
Long head of the biceps pathology as a cause of anterior shoulder pain after shoulder arthroplasty.

The use of shoulder arthroplasty has been increasing over the last decade, with nearly 20,000 shoulder arthroplasties being performed each year. Although many patients have excellent results, there exists a subset of patients in whom anterior catching shoulder pain develops after arthroplasty. The purpose of this study was to examine this group of patients and explore treatment options and outcomes for this condition. We undertook a review of 8 shoulders in 7 patients who were treated for anterior shoulder pain radiating into the biceps muscle after shoulder arthroplasty. Three patients had a hemiarthroplasty for fracture, and five had a total shoulder arthroplasty. All patients had anterior shoulder pain with physical examination findings consistent with biceps tendon pathology. Definitive diagnosis and treatment consisted of either arthroscopy, in 7 of 8 shoulders, or an open procedure, in 1 of 8 shoulders. The range of motion improved in all shoulders. The hemiarthroplasty group showed an increase in flexion of 36° (range, 68°–104°), external rotation of 23° (range, 11°–34°), and internal rotation to L4. The total shoulder group demonstrated an increase in flexion of 50° (range, 66°–166°), external rotation of 27° (range, 22°–39°), and internal rotation to L3. The Hospital for Special Surgery score improved in all shoulders, with all patients being satisfied with their final outcome. Pain scores improved from a mean of 6.9 (range, 4–9) preoperatively to 1.4 (range, 0.5–2) postoperatively on a scale of 1 to 10, with 10 indicating the most pain. The role of the biceps tendon in the pathology of anterior shoulder pain after shoulder arthroplasty appears to be consistent with fibrosis and inflammation. Initial results, achieved with arthroscopic debridement or tenodesis, were encouraging.
Ice concentration and distribution near the south pole of Mars: Synthesis of odyssey and global surveyor analyses

[1] Mars Odyssey Gamma-Ray Spectrometer (GRS) neutron spectrometer data are analyzed to determine the concentration and boundary of buried water ice near the south pole. The measurements are consistent with a circumpolar layer of average ice concentration from 35 to 100% by weight and superposed dust with thickness density product 30 to 40 g/cm2. The region of buried water ice extends from near the south pole to latitudes 48S to 58S. The equatorward boundary of the ice-rich region compares favorably with the boundary of an ice-rich dust mantle inferred from Mars Orbiter Laser Altimeter data and the locations of dissected terrain inferred from Mars Orbiter Camera images. The ice-rich mantle is identified as the source of enhanced hydrogen sensed by the neutron spectrometer.
A Contractualist Reading of Kant's Proof of the Formula of Humanity

Kant offers the following argument for the formula of humanity (FH): Each rational agent necessarily conceives of her own rational nature as an end in itself and does so on the same grounds as every other rational agent, so all rational agents must conceive of one another's rational nature as an end in itself. As it stands, the argument appears to be question-begging and fallacious. Drawing on resources from the formula of universal law (FUL) and Kant's claims about the primacy of duties to oneself, I propose a contractualist reconstruction of this puzzling line of reasoning.
Evidence of conformational selection driving the formation of ligand binding sites in protein-protein interfaces.

Many protein-protein interactions (PPIs) are compelling targets for drug discovery, and in a number of cases can be disrupted by small molecules. The main goal of this study is to examine the mechanism of binding site formation in the interface region of proteins that are PPI targets by comparing ligand-free and ligand-bound structures. To avoid any potential bias, we focus on ensembles of ligand-free protein conformations obtained by nuclear magnetic resonance (NMR) techniques and deposited in the Protein Data Bank, rather than on ensembles specifically generated for this study. The measures used for structure comparison are based on detecting binding hot spots, i.e., protein regions that are major contributors to the binding free energy. The main tool of the analysis is computational solvent mapping, which explores the surface of proteins by docking a large number of small “probe” molecules. Although we consider conformational ensembles obtained by NMR techniques, the analysis is independent of the method used for generating the structures. Finding the energetically most important regions, mapping can identify binding site residues using ligand-free models based on NMR data. In addition, the method selects conformations that are similar to some peptide-bound or ligand-bound structure in terms of the properties of the binding site. This agrees with the conformational selection model of molecular recognition, which assumes such pre-existing conformations. The analysis also shows the maximum level of similarity between unbound and bound states that is achieved without any influence from a ligand. Further shift toward the bound structure assumes protein-peptide or protein-ligand interactions, either selecting higher energy conformations that are not part of the NMR ensemble, or leading to induced fit. Thus, forming the sites in protein-protein interfaces that bind peptides and can be targeted by small ligands always includes conformational selection, although other recognition mechanisms may also be involved.
Evolution and decoherence in finite level systems

Abstract Forms of dynamics of open finite level systems is formulated. We give a presentation of stochastic dynamics of such systems in terms of maps. Completely positive maps are classified and parametrized. If the system is coupled to a companion system, the contraction of the unitary evolution of the combined system leads to a completely positive map of the system density matrix. The inverse problem of embedding a stochastic map in a unitary map of the combined system is posed and solved. This construction is not unique. Dephasing and decoherence stem from the same mechanism. The decoherence induced may be viewed in terms of the distance between the diagonal forms of the initial density matrix and the final: D =∑ i | λ ′ i − λ i |. The unitary factor of the evolution does not contribute to the decoherence so defined. A model is given for the stochastic evolution of a qubit coupled to a qubit. This yields a completely positive map for the original qubit. A triangle inequality constraint obtains for the three relaxation times; and it is due to the complete positivity of the map. Some comments are made about bipartite entangled systems in relation to maps.
Prognostics for advanced compressor health monitoring

Axial flow compressors are subjected to demands for ever-increasing levels of pressure ratio at a compression efficiency that augments the overall cycle efficiency. However, unstable flow may develop in the compressor, which can lead to a stall or surge and subsequently to gas turbine failure resulting in significant downtime and cost to repair. To protect against these potential aerodynamic instabilities, compressors are typically operated with a stall margin. This means operating the compressor at less than peak pressure rise which results in a reduction in operating efficiency and performance. Therefore, it is desirable to have a reliable method to determine the state of a compressor by detecting the onset of a damaging event prior to its occurrence. In this paper, we propose a health monitoring scheme that gathers and combines the results of different diagnostic tools to maximize the advantages of each one while at the same time minimizing their disadvantages. This fusion scheme produces results that are better than the best result by any one tool used. In part this is achieved because redundant information is available that when combined correctly improves the estimate of the better tool and compensates for the shortcomings of the less capable tool. We discuss the usage of diagnostic information fusion for a compressor event coupled with proactive control techniques to support improved compressor performance while at the same time avoid the increased damage risk due to stall margin reduction. Discretized time to failure windows provide event prediction in a prognostic sense.
A longitudinal examination of re-employment quality on internalizing symptoms and job-search intentions.

Underemployed workers—those receiving less pay, working fewer hours, or using fewer skills than they would prefer—appear to experience negative mental health outcomes similar to the unemployed. Prior cross-sectional research provides mixed empirical evidence for this conclusion, however. The current study sought to clarify the impact of underemployment longitudinally, assessing mental health five times over eight months following job loss. In addition to the commonly used indicators of underemployment, we designed a measure of cognitive complexity using the Occupational Information Network (O*NET), an extensive government database used to organize and categorize occupational information. Replicating past research, we found concurrent associations between all indexes of re-employment job quality and internalizing symptoms in the period immediately after re-employment. However, when controlling for quality of prior employment, all indicators except our measure for cognitive complexity became non-significant. As participants transitioned from unemployment to re-employment, only reductions in cognitive complexity were associated with sustained general internalizing symptoms. We also found that although changes in cognitive complexity had an immediate impact on the well-being of the recently re-employed, only the number of available weekly hours (full-time vs. part-time status) was relevant 6-12 weeks later. Our longitudinal model thus provides significant nuance to the current understanding of underemployment and mental health.
Afternoons in Asia Minor, Beyoglu at Night

early on in my stay because of daily news reports concerning the recent assassina-­ tion at the Council of State in Ankara of a Turkish judge who had refused to relax the rules on the wearing of headscarves. No sooner had I settled in the city in the latter part of May than I witnessed a demonstration by Turkish lawyers on Istiklal Caddesi, in the Beyoglu district near my hotel. A statement was read by the head of the Istanbul Bar who said, “I call on all people and institutions that are partly responsible for the attack to respect all the institutions of the republic and obey the judicial rulings.” Based on my observation, it was also true that the vast majority of women walking day or night around lively Beyoglu, home to numerous restaurants, shops, galleries, theatres, foreign embassies, and cultural centers, were not wearing headscarves.
Web services security configuration in a service-oriented architecture

Security is one of the major concerns when developing mission-critical business applications, and this concern motivated the Web Services Security specifications. However, the existing tools to configure the security properties of Web Services give a technology-oriented view; only assisting in choosing data to encrypt and the encryption algorithms to use. A user must manually bridge the gap between the security requirements and the configuration, which could cause extra configuration costs and lead to potential misconfiguration hazards. To ease this situation, we came up with refining security requirements from business to technology, leveraging the concepts of Service-Oriented Architecture (SOA) and Model-Driven Architecture (MDA). Security requirements are gradually transformed to more detailed ones or countermeasures by bridging the gap between them by using best practice patterns.
Corrective osteotomy for pes varus in the Dachshund

Five dachshunds were treated for a distal varus deformity of one tibia. Angulations of 20 degrees to 30 degrees resulted from shortening of the medial tibial length with the maximum curvature at the distal metaphysis. Comparison with the contralateral limbs was required to determine the amount of correction necessary for functional and cosmetic results. Open wedge osteotomies stabilized with a modified type II external fixator resulted in correction of the deformities, early return of limb function, and healing of the osteotomies.
A revised staging system for breast cancer.

: The sixth edition of the American Joint Committee on Cancer (AJCC) staging system for invasive and in situ breast cancer has significant implications for the maximization of patient care. These evidence-based standards now reflect current standards of care and practice. Guidelines for a more uniform and accurate primary tumor analysis, including grade, size, and histologic classification are now provided, as well as standards for diagnosis and handling of microinvasion, multiple ipsilateral or contralateral carcinomas, and inflammatory carcinomas. The reporting of nodal metastasis has been refined and the characterization of metastatic disease has been revised. These revised guidelines should now be used for patient categorization, data gathering, and clinical categorization. National adaptation of these changes should greatly facilitate inter- and intrainstitutional standardization and data gathering.
First Record of Amblyomma auricularium (Acari: Ixodidae) in the United States

Amblyomma auricularium (Conil) was collected from an armadillo in Glades County, FL. Two females and 11 males were collected. This is the first record of this species in the United States.
Varicose Veins: Venous Wall Changes, Inflammation, and Matrix Metalloproteinases

Varicose veins are superficial vessels that are abnormally twisted, lengthened, or dilated, and they are usually caused by inefficient or defective valves within the vein. Varicose veins are part of the spectrum of chronic venous diseases (CVDs), which affect millions of people throughout Western populations [1]. There is significant evidence in the literature that wall dysfunction consisting of alterations in the endothelium and smooth muscle cells (SMCs) are a principal cause for varicose veins [2]. In addition, matrix metalloproteinases (MMPs) are present in varicose veins and can be found in the endothelium, smooth muscle, and adventitial layers of the vein wall [3]. However, it is unclear whether the presence of MMPs is a result of chronic inflammation and venous wall remodeling or whether MMPs actually functional in veins, causing biochemical changes in the venous wall, leading to early dilation and chronic irreversible changes typified by varicose veins [2]. Furthermore, the role of venous wall dysfunction appears to precede valve dysfunction, is linked to MMPs [2], and is tightly regulated by hypoxia inducible factor.
Articulate forgiveness and normative constraints

Philosophers writing on forgiveness typically defend the Resentment Theory of Forgiveness, the view that forgiveness is (or crucially implicates) the overcoming of resentment. Rarely is much more said about the nature of resentment or how it is overcome when one forgives. Pamela Hieronymi, however, has advanced detailed accounts both of the nature of resentment and how one overcomes resentment when one forgives. In this paper, I argue that Hieronymi’s account of the nature of forgiveness is committed to two implausible claims about the norms bearing on forgiveness. Her account is highly instructive, however, for it brings into relief how certain intuitive views about the norms of forgiveness should be used to constrain our theories about its nature. I conclude by defending this methodological proposal.
The Impact of Inflation on Home Prices and the Valuation of Housing Characteristics Across the Price Distribution

Applying quantile regression to over 136,000 single-family home sales in the Jacksonville, Florida area for the period 1990 to 2006, this study shows that the valuation of housing characteristics d...
Striving for Response Accuracy: Experiments in New Interviewing Techniques:

A dual program analyzed response invalidity and experimented with interviewing techniques designed to improve reporting. Respondent perceptions, interviewer behavior, and the relation of invalidity...
Abstract 825: Molecular mechanisms of regulation of cytochrome P4501A enzymes by 3-methylcholanthrene (MC) in micein vivo

3-Methylcholanthrene (MC) is one of the most potent polycyclic aromatic hydrocarbons (PAHs) present in cigarette smoke, diesel exhausts, and charcoal broiled meats, etc. Cytochrome P450 (CYP)1A enzymes play key roles in the activation of PAHs to carcinogenic metabolites. We previously showed persistent induction of CYP1A enzymes by MC in vivo. In this study, we tested the hypothesis that MC elicits persistent induction of CYP1A1 in vivo by sustained transcriptional activation of the CYP1A1 promoter. Thirty two C57B6 (WT) mice were divided into two groups. Group I was treated with vehicle corn oil (CO) (8ml/kg) and group II was treated with a single dose of MC (100 μmol/kg), i.p. Four animals from each group were sacrificed at 6, 12, 24, and 48 h after MC withdrawal. The mRNA levels, protein content and enzyme activities of CYP1A1 were determined by real-time PCR, Western blotting, and fluorimetry, respectively at different time points. In addition, the binding of MC-AHR-AHR nuclear translocator (ARNT) to the AHREs on the CYP1A1 promoter region were determined by chromatin immunoprecipitation (ChIP) assay. The translocation of AHR was also analyzed by immunofluorescence. The ChIP experiments indicated that transcriptional activation of CYP1A1 was most pronounced at 6 h, followed by 12 h, but declined at later time points. On the other hand, the expression of CYP1A1 at the mRNA, protein and enzyme levels persisted for up to 48 h both in lung and liver tissues. These results suggest that transcriptional activation of CYP1A1 at 6-12 h is sufficient to result in sustained induction of CYP1A mRNA and protein expression for up to 48 h. Isolation of the immunoprecipitated promoter fragment (containing the xenobiotic response elements), which binds to the MC-AHR complex, followed by 32P-postlabeling revealed the formation of MC-DNA adducts, suggesting that DNA adducts are sequence-specific and target the CYP1A1 promoter. Our results suggest that DNA adducts might play a role in regulation of CYP1A1 by MC, a phenomenon that may be of relevance to PAH-mediated carcinogenesis. Citation Format: Bhagavatula Moorthy, Jiang Weiwu, Lihua Wang, Chun Chu, Sudha R. Kondraganti, Paramahamsa Maturu. Molecular mechanisms of regulation of cytochrome P4501A enzymes by 3-methylcholanthrene (MC) in mice in vivo. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 825. doi:10.1158/1538-7445.AM2015-825
Cytolysis in agar of thymus cells by antibody-forming cells.

SummaryRat thymus cells were used as target cells in Jerne agar plaque technique to detect and enumerate antibody-forming cells of mouse stimulated with this antigen. 51Cr-labeled rat thymus cells were also used in these experiments to carry out plaque assay autoradiographically. The techniques demonstrated complement-dependent cytolytic plaques caused by antibodies released from immune mouse spleen cells and could be used to investigate kinetics of antibody-forming cells.
Convergence in Mean and Lebesgue Integration

(1937). Convergence in Mean and Lebesgue Integration. The American Mathematical Monthly: Vol. 44, No. 1, pp. 4-14.
AN INVESTIGATION OF THE RESPONSE OF THE SPOUSE TO CHRONIC PAIN BEHAVIOR

A study was conducted to assess the responses of spouses to chronic pain behavior. In this study, spouses watched videotapes of "painful" and "neutral" facial expressions emitted both by their mates, hospitalized chronic pain patients, and by a number of performers. Skin conductance and heart rate to each of these displays were monitored and spouses also rated the perceived pain intensity of each display. Spouses showed greater increases in skin conductance to painful than to neutral facial displays, whether emitted by performers or by patients. Additionally, spouses reporting relatively high levels of marital satisfaction showed greater increases in skin conductance to the painful displays of their mates than did relatively unsatisfied spouses, while both groups gave similar ratings to these same displays. Implications of these data for the development of psychiatric and psychosomatic difficulties in responses of chronically ill patients are discussed.
POLGI Mutations in Infantile Hepatocerebral Syndromes

Nine patients, 2 sibling pairs and 5 singleton cases, with POLGI mutations associated with infantile fatal encephalopathy and hepatopathy, 8 having typical Alpers’ syndrome (Alpers’ hepatopathic poliodystrophy) and one a severe floppy infant syndrome with hepatic failure, are reported from the National Institute of Neurology, Milano; Meyer Children’s Hospital, Florence; University of Verona; University Hospital, Monza, Italy; and University Children’s Hospital, Hamburg, Germany.
Autonomous Navigation of a Quadrotor in Indoor Environments for Surveillance and Reconnaissance

This paper presents the research on the development of an autonomous quadrotor with the ability to navigate indoor environments and simultaneously map them. The system utilizes Simultaneous Localization and Mapping (SLAM) as its mapping technique by using a 3-Dimensional camera. The program utilized with the camera is SCENECT, open source software based on the laser scan software SCENE by FARO. A 3-D depth map is constructed by the infrared monochrome camera’s reception of reflected infrared signals that are produced by the infrared projector. Chromatic and 3-D depth images are obtained simultaneously with the object’s features by using the RGB camera. Ultrasonic rangefinders are implemented into the system for obstacle detection.
Abstract 513: Role of Heparanase in Atherosclerotic Plaque Formation

Little is know about the role of enzymatic regulation of glycosaminoglycans in the formation of atherosclerotic plaques. Heparanase is the only known mammalian enzyme that degrades the glycosaminoglycan heparan sulfate. We tested the hypothesis that heparanase could regulate atherogenesis and atherosclerotic plaque severity. We transduced human endothelial cells with lentiviruses expressing one of four different constructs expressing shRNA targeted to heparanase or a scrambled control sequence. These shRNA knocked down the expression of heparanase to 30-50% of wild type expression levels. These lines were selected using puromycin and confirmed for gene modulation using immunostaining and western blotting for heparanase. The ability to uptake lipids was tested using fluorescently labeled, oxidized low-density lipoprotein (OxLDL). We found that cells expressing 30% of the heparanase protein in wild type cells had increased uptake of OxLDL in comparison to wild type cells (1.8+0.1 versus 1.00+0.07 of normali...
Financial Weapons of War

A new type of warfare is upon us. In this new mode of war, finance is the most powerful weapon, bullets are not fired, financial institutions are the targets, and almost everyone is at risk. Instead of smart bombs, improvised explosives, and unmanned drones –– economic sanctions, financial restrictions, and cyber programs are the weapons of choice. This is the reality of modern financial warfare.This Article offers an early examination of this new mode of war. It explores the new financial theater of war, analyzes the modern arsenal of financial weapons, highlights emerging legal tensions, and proposes key recommendations for current and future financial warfare. The Article begins with a general survey of the modern financial infrastructure, the emerging battlefield of modern warfare. Next, it provides a more detailed inventory of the financial weapons of war. It accounts for traditional weapons like economic sanctions, anti-money laundering regulations, and banking restrictions, as well as cyber weapons like distributed denial-of-service attacks, data manipulation hacks, and destructive intrusions. It also explains how these weapons are used in current conflicts with Al Qaeda, Iran, ISIS, North Korea, Russia, and Syria. The Article then contends with new tensions relating to financial hostilities, cyberattacks, and non-state actors posed by financial warfare for longstanding legal doctrines. Finally, it recommends innovative cybersecurity incentives, advanced technological stress tests, and comprehensive financial war games as three pragmatic proposals that should be undertaken in response to modern financial warfare while larger issues are still being deliberated by global policymakers. Ultimately, this Article provides an early framework for thinking and acting anew about modern financial warfare and the financial weapons of war.
Estimating index of refraction for material identification in comparison to existing temperature emissivity separation algorithms

As off-nadir viewing platforms become increasingly prevalent in remote sensing, material identification techniques must be robust to changing viewing geometries. Current identification strategies generally rely on estimating reflectivity or emissivity, both of which vary with viewing angle. Presented here is a technique, leveraging polarimetric and hyperspectral imaging (P-HSI), to estimate index of refraction which is invariant to viewing geometry. Results from a quartz window show that index of refraction can be retrieved to within 0.08 rms error from 875-1250 cm -1 for an amorphous material. Results from a silicon carbide (SiC) wafer, which has much sharper features than quartz glass, show the index of refraction can be retrieved to within 0.07 rms error. The results from each of these datasets show an improvement when compared with a maximum smoothness TES algorithm.
Influence of ppGalNAc-T10 on Biological Properties of Colon Cancer Cell Line LoVo

To probe how polypeptide: N-acetylgalactosaminyltransferase 10(ppGalNAc-T10) affects colon cancer cell line LoVo.PcDNA3.1-T10-ORF,pcDNA3.1-T10-antisense and vacuity carrier pcDNA3.1 were separately transfected into LoVo.Western blot was used to detect expression status of ppGalNAc-T10.The proliferation of LoVo affected by ppGalNAc-T10 was detected through CCK8,the change of motility detected by wound healing experiment and invasion by transwell experiment.The protein expression status detected by Western blot method showed difference.With the increase of expression of ppGalNAc-T10,the cell growth was depressed and the ability of motility and invasion declined.However,the LoVo transfected pcD-NA-T10-antisense's cell growth was increased,and so did the ability of motility and invasion.It is possible that the tune-up and tune-down of ppGalNAc-T10 have some influence on biological properties of colon tumor.
Can there be a meaningful participation of Croat expatriates in Croatian science

The author discusses the possible role for Croat expatriate scientific community in Croatian science. He argues that proper leadership could engage Croatian expatriate scientific community in supporting the foundation of a multidisciplinary science institute in Split, Croatia. The institute could play a key role in regional economic development focused on health, energy, and environment. Establishment and maintenance of a program of such magnitude requires a diminished and more flexible role of the government and introduction of the private sector in a government-private partnership. Development of necessary attitudes and economic base will take time.
Pediatric behavioral dentistry.

Une modification du comportement en ce qui concerne l'hygiene dentaire previendrait une grande part des problemes dentaires actuels. L'article propose un apercu de programmes educatifs, issus de la collaboration entre dentistes et psychologues du comportement, ayant pour but de renforcer l'apprentissage comportemental en matiere de sante et de modifier les representations negatives associees a la visite chez le dentiste
Differential effect of clozapine on weight: a controlled study.

Objective : This study examined whether clozapine induces more weight gain than haloperidol and whether weight gain is related to clinical improvement. Method : The weight and symptoms of 39 outpatients with schizophrenia who were randomly assigned to double-blind treatment with either clozapine or haloperidol were assessed. The weight and symptoms of 33 of the patients who chose to take clozapine during a 1-year follow-up after the study ended were also assessed. Results : The patients treated with clozapine gained significantly more weight over baseline (7%) than the haloperidol-treated patients (1%). Weight gain was not significantly correlated with improvements in either positive or negative symptoms. Fifty-eight percent of the patients followed for 1 year gained at least 10% over their baseline weight. Conclusions : Weight gain is an important side effect of clozapine and is unrelated to the drug's differential antipsychotic efficacy.
A moderate rationalism

INTRODUCTION The argument of the previous chapters leads to the striking or perhaps even startling conclusion that empiricist positions on a priori justification and knowledge, despite their apparent dominance throughout most of the twentieth century, are epistemological dead ends: the moderate empiricist attempt to reconcile a priori justification with empiricism by invoking the concept of analyticity does not succeed, indeed does not really get off the ground; and the radical empiricist attempt to dispense entirely with such justification ends in a nearly total skepticism. The indicated conclusion is that a viable non-skeptical epistemology, rather than downgrading or rejecting a priori insight, must accept it more or less at face value as a genuine and autonomous source of epistemic justification and knowledge. This is the main thesis of epistemological rationalism and also the central thesis of the present book. Obviously, however, such a result can be no more than tentative until the rationalist view has been explored more fully and shown to be defensible. For even if the objections to the two positive empiricist views are indeed decisive, as claimed here, the possibility remains that the negative empiricist claim is correct: that a priori justification as understood by the rationalist simply does not exist.
Mendelian Disorders of RANKL/OPG/RANK Signaling

Identification of the RANKL/OPG/RANK signaling pathway as the principal regulator of osteoclast (OC) formation and action began with the discoveries of new members of the tumor necrosis factor (TNF) superfamily (RANKL, OPG, and RANK). Subsequently, genetically altered mice revealed the importance of these molecules for bone biology and helped to show that binding of RANKL to RANK promotes osteoclastogenesis and increases skeletal remodeling, whereas coupling of RANKL to OPG inhibits these processes. The significance of this pathway for humans was then demonstrated by the discoveries that mutations in the genes that encode RANK ( TNFRSF11A ), OPG ( TNFRSF11B ), and RANKL ( TNFSF11 ) explain: (1) several rare mendelian disorders (familial expansile osteolysis, early-onset Paget’s disease of bone, expansile skeletal hyperphosphatasia, and juvenile Paget’s disease) that resemble classic late-onset Paget’s disease of bone featuring enhanced osteoclastogenesis; or (2) forms of osteopetrosis featuring impaired OC formation. This chapter reviews the disease features and genetic bases for these instructive disorders of skeletal biology.
Digital signal processing system design: using LabVIEW and TMS320C6000

LabVIEW, developed by National Instruments, is a graphical programming environment suited for high-level or system-level design. It allows the integration of different signal processing components or subsystems within a graphical framework. This paper introduces a LabVIEW-based book being written for the purpose of furnishing a textbook for DSP laboratory courses offered at many engineering schools. Two examples, namely signal filtering and DTMF receiver, are presented to show how DSP systems are designed using the LabVIEW graphical programming environment. In addition, the book presents the way to implement any desired component(s) of a DSP system on Texas Instruments C6x DSK boards. It is shown how the real-time data exchange feature of the TI Code Composer Studio allows users to establish a communication link between a host PC running LabVIEW and a C6x DSK board.
Outcome of Dana-Farber Cancer Institute (DFCI) Consortium Protocol 95–01 for Children with Newly Diagnosed Acute Lymphoblastic Leukemia (ALL).

DFCI Consortium Protocol 95–01 was designed to minimize therapy-related morbidity for children with newly diagnosed ALL without compromising efficacy. Patients were considered high risk (HR) if they met any of the following criteria: 1) white blood cell count (WBC) ≥ 50,000/microliter, 2) age between
Expanding Lipidome Coverage Using LC-MS/MS Data-Dependent Acquisition with Automated Exclusion List Generation

Untargeted omics analyses aim to comprehensively characterize biomolecules within a biological system. Changes in the presence or quantity of these biomolecules can indicate important biological perturbations, such as those caused by disease. With current technological advancements, the entire genome can now be sequenced; however, in the burgeoning fields of lipidomics, only a subset of lipids can be identified. The recent emergence of high resolution tandem mass spectrometry (HR-MS/MS), in combination with ultra-high performance liquid chromatography, has resulted in an increased coverage of the lipidome. Nevertheless, identifications from MS/MS are generally limited by the number of precursors that can be selected for fragmentation during chromatographic elution. Therefore, we developed the software IE-Omics to automate iterative exclusion (IE), where selected precursors using data-dependent topN analyses are excluded in sequential injections. In each sequential injection, unique precursors are fragmented until HR-MS/MS spectra of all ions above a user-defined intensity threshold are acquired. IE-Omics was applied to lipidomic analyses in Red Cross plasma and substantia nigra tissue. Coverage of the lipidome was drastically improved using IE. When applying IE-Omics to Red Cross plasma and substantia nigra lipid extracts in positive ion mode, 69% and 40% more molecular identifications were obtained, respectively. In addition, applying IE-Omics to a lipidomics workflow increased the coverage of trace species, including odd-chained and short-chained diacylglycerides and oxidized lipid species. By increasing the coverage of the lipidome, applying IE to a lipidomics workflow increases the probability of finding biomarkers and provides additional information for determining etiology of disease. Graphical Abstract ᅟ.