cssi/SciSciGPT-SciSciNet huggingface dataset:
Abstract 1974: Consequence of the tumor-associated deletion of CHD1 on transcriptional output and tumor progression

CHD1 is a member of the super-family of chromatin modifier proteins, and is characterized by the presence of several chromo-domains as well as an ATP dependent helicase domain. A multitude of studies across several model systems have demonstrated that CHD1 functions as a transcriptional co-activator, responsible for efficient RNA polymerase II (RNA pol II) ejection from the transcriptional start site as well as maintenance of RNA pol II processivity across the gene body. This is accomplished largely though nucleosome remodeling ahead of RNA pol II, which efficiently reorganizes nucleosome position to allow for optimal RNA pol II function. Consequently, as CHD1 plays a critical role in transcriptional competency, tumor associated deletions and/or mutations of the CHD1 gene that compromise its function are rare. Interestingly, prostate cancer proves to be the exception, where the CHD1 locus is deleted with high frequency in primary disease. Tumors harboring homozygous deletion of CHD1 belong to a subclass of prostate cancer that are enriched for either SPOP or FOXA1 mutations, suggesting a prostate-specific, tumor suppressive role for CHD1 in this genomic context. Importantly, while the oncogenic functions of both FOXA1 and SPOP mutations have been largely defined, little is known as to how CHD1 loss contributes to tumor initiation or progression. Here, using 3D organoid cultures derived from GEM models of inducible CHD1 loss, prostate specific cells were found to have dramatically altered transcriptionally competency upon CHD1 depletion. These events were correlated with an aberrant, tumor-associated transcriptome, resulting in changes in morphology and growth. Furthermore, while genome wide assessment of CHD1 occupancy in human prostate cancer models uncovered an enrichment of CHD1 at sites of active transcription, loss of CHD1 did not dramatically affect expression of genes associated with tumor progression. Inversely, genomic loss of CHD1 was associated with changes in lineage dependent markers, suggesting that a major function of CHD1 is to regulate the differentiation state of prostate cells. Collectively, these data help to define the tumor suppressive role for CHD1 in prostate cancer tumorigenesis, and suggest that loss of CHD1 could alter the function of key transcriptional regulators associated with prostate cancer initiation and progression. Citation Format: Michael A. Augello, Mirjam Blattner-Johnson, Mark Rubin, Christopher Barbieri. Consequence of the tumor-associated deletion of CHD1 on transcriptional output and tumor progression. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1974.
Simple Wavelet Sets for Scalar Dilations in ℝ2

Wavelet sets for dilation by any scalar d > 1 in L2(ℝ2) are constructed that are finite unions of convex polygons. Such simple wavelet sets for dilation by 2 were widely conjectured to be impossible. The examples are built using the generalized scaling set technique of Baggett et al. [3]. Generalizations to other expansive dilations in L2(ℝ2) are discussed.
Readiness for Interprofessional Learning After Participation in an Obstetric Simulation

Abstract Purpose The importance of interprofessional education (IPE) is widely documented yet remains underutilized in clinical education. The purpose of this study is to determine student readiness for continued IPE after engaging in an obstetric simulation. Methodology A pre/postsurvey with a descriptive design was implemented. Results Students were very positive about IPE even before the simulation. Students who did not initially view IPE favorably had a significant increase in readiness for IPE after the simulation experience.
Integration of Math Jingles into Physiology Courses

Biology, especially physiology, includes quantitative relationships that explain key concepts, yet many biology students have poor math skills or math anxiety which might hinder their learning. We propose that students who are motivated to learn but are intimidated by math may benefit from in-class activities such as singing or listening to content-rich jingles that make the relevant math more accessible. Here we describe a three-part process by which we have used feedback from 231 students in four college physiology classes to develop math- related jingles suitable for use in similar classes. In Part 1, we report three classes’ overall reactions (>60% positive) to educational songs as reported in standard multiple-choice surveys, while noting the limitations of this approach. In Part 2, we mine open-ended survey comments for common themes among students’ reactions. Among music-related comments, we repeatedly find three main constructive suggestions: songs should be kept very short; connections between lecture material and songs must be obvious; and songs must be heard or sung more than once to be maximally helpful. In Part 3, we present seven mathematical physiology jingles (with URLs for online access) whose development was driven partly by insights from Part 2.
The roles of socializers in career choice decisions for high school students in rural central Appalachia: “Who's doing what?”

Students from low social economic status (SES) groups remain underrepresented in higher education and particularly in STEM fields. From existing literature, we know some of the barriers in promoting STEM careers among people in low SES groups include a lack of role models, understanding or misconceptions of STEM careers, and knowing about STEM career opportunities. The purpose of our research is to explore the potential influence of socializers on students as they make career choice decisions (primarily in science and engineering) from student's and educator's perspectives. We focused on students from Appalachia because they typically come from lower SES, are often first generation college (FGC) students, and are underrepresented in STEM fields, making their college and career choices particularly important to understand. We framed our research in Eccles' Expectancy Value Theory using data from an on-line informational questionnaire with educational stakeholders and in-person interviews with high school students from rural central Appalachia. Consistent with EVT, our findings reveal that students consider their parents and their educators as valuable socializers. Educators, however, value outreach activities provided by professionals to help students explore engineering career choices. This is consistent with a reported lack of confidence in ability to talk with students regarding engineering careers. By comparing the perspectives of students and educators, we begin to address the potential gaps of “who's doing what” with respect to assisting students as they navigate career choice decision making in high school.
Haloperidol undermining gastroparesis symptoms (HUGS) in the emergency department.

Abstract Background Gastroparesis associated nausea, vomiting & abdominal pain (GP N/V/AP) are common presentations to the emergency department (ED). Treatment is often limited to antiemetic, prokinetic, opioid, & nonopioid agents. Haloperidol (HP) has been shown to have analgesic & antiemetic properties. We sought to evaluate HP in the ED as an alternative treatment of GP N/V/AP. Methods Using an electronic medical record, 52 patients who presented to the ED w/GP N/V/AP secondary to diabetes mellitus and were treated w/HP were identified. Patients who received HP were compared to themselves w/the most recent previous encounter in which HP was not administered. ED length of stay (LOS), additional antiemetics/prokinetics administered, hospital LOS, and morphine equivalent doses of analgesia (ME) from each visit were recorded. Descriptive statistics, categorical (Chi Square Test or Z-Test for proportion) and continuous (Wilcoxon Signed Rank Test) comparisons were calculated. Statistical significance was considered for two tail p-values less than 0.05. Results A statistically significant reduction in ME (Median 6.75 [IQR 7.93] v 10.75 [IQR12]: p = 0.001) and reduced admissions for GP (5/52 v 14/52: p = 0.02) when HP was administered was observed. There were no statistically significant differences in ED or hospital LOS, and additional antiemetics administered between encounters in which HP was administered and not administered. No complications were identified in patients who received HP. Conclusions The rate of admission and ME was found to be significantly reduced in patients with GP secondary to diabetes mellitus who received HP. HP may represent an appropriate, effective, and safe alternative to traditional analgesia and antiemetic therapy in the ED management of GP associated N/V/AP.
An integral‐imaging‐based head‐mounted light field display using a tunable lens and aperture array

A head-mounted light field display based on integral imaging is considered as one of the promising methods that can render correct or nearly correct focus cues and address the well-known vergence-accommodation conflict problem in head-mounted displays. Despite its great potential, it still suffers some of the same limitations of conventional integral imaging-based displays such as low spatial resolution and crosstalk. In this paper, we present a prototype design using tunable lens and aperture array to render 3D scenes over a large depth range while maintaining high image quality and minimizing crosstalk. Experimental results verify and show that the proposed design could significantly improve the viewing experience.
The Justice of Unequal Pay in the UFC: An In-Depth Analysis of the Fighter's Antitrust Class Action Lawsuit Against the UFC and the Misplaced Support of the Proposed Muhammad Ali Expansion Act

Athletes always want more money, they all believe they deserve a bigger check and the athletes of the Ultimate Fighting Championship (“UFC”) are no different. Fighters of the most prominent mixed marital arts (MMA) promotion, the UFC, feel as though they are not being compensated adequately. Hardly a week passes when the sports media does not feature one of the UFC’s contenders or champions grumbling about lack of pay. Being that the UFC recently sold for a record 4 billion dollars, setting the record for largest sale in sports history, they may be right... Disgruntled fighters have turned to litigation and legislation for a remedy but, these courses of action will by provide no such relief. Several ex-UFC fighters have brought a class action antitrust lawsuit against the UFC. They claim the UFC has a monopoly of the sport and its athletes and using that monopoly power to restrain trade and stifle fighter pay. This article discusses the merits of that lawsuit by exposing the flaws in the plaintiff’s argument. The article then switches gears to discuss the proposed Muhammad Ali Expansion Act. Many fans and fighters favor this proposed expansion. This legislation would take the protections afforded to professional boxers and apply them to the athletes of the UFC. Unfortunately, the Muhammad Ali Act, as it stands, has been deficient in protecting boxers, and there is no reason to expect anything different for athletes of the UFC. A consistent theme exists throughout the article. The article emphasizes of how the UFC’s centralized control of the MMA market is a good thing for the sport and how disturbing the structure may injure the product. The article should convince the athletes to oppose or at least see the lack of viability of these routes and encourage them to work with the UFC to resolve these issues rather than being adversaries. While at the same time inspiring the UFC to work with the athletes to resolve these issues.
Representation Theory of Finite Groups

This chapter is on the representation theory of finite groups. For further details, we refer the reader to [17]. Throughout, G is a finite group of cardinality n and K is algebraically closed of characteristic 0, or of characteristic p where p does not divide n.
Leadership Among School Children in a Catholic School: A Courageous Dance of Love

This chapter presents a set of reflections on leadership in Catholic schools. It uses the metaphor of a courageous dance of love. It is argued that what makes Catholic School Leadership different is wrapped up with a willingness to use the word love to frame the discussion about Catholic education. To explain the distinctive characteristics of Catholic School Leadership a concept drawn from Jesuit educational ideas, that of the magis or ‘more’ of a Catholic education. It is in this respect that concept of ‘agape’ can be used to characterise Catholic schools leadership. It is proposed that Catholic School Leadership is ultimately about loving leadership in action.
Spin Tunneling in Magnetic Molecules That Have Full or Partial Mechanical Freedom

While most of the research on spin tunneling in molecules has focused on crystals of molecular magnets, future experiments may involve molecules loosely attached to a substrate, as well as free magnetic molecules. What would be the effect of the mechanical freedom on spin tunneling? Exact solutions for this set of problems have been recently obtained. They involve anomalous commutation relations for spin and rotational angular momentum in the rotating frame of reference. Application of these findings to magnetic molecules points towards important effect of the mechanical freedom on spin tunneling. In a free molecule the tunneling is prohibited unless the molecule is sufficiently heavy and the tunnel splitting is large.
The Application of Phonological Universals in Speech Pathology

Publisher Summary This chapter discusses the application of phonological universals in speech pathology. An examination of the phonologies of the languages of the world permits some generalizations. These generalizations are good candidates for phonological universals, that is, cross-language regularities in the behavior or patterning of speech sounds. A sound pattern need not be exceptionless or manifest in every human language to count as a universal. It is assumed, however, that the causes of these patterns are universal in an absolute sense and are potentially manifest in every human language in every human speaker. However, their actual realization may vary from language to language because of language-specific factors—for example, historical, psychological, and cultural.
A symmetric view of utilities and probabilities

Motivated by the need to reason about utilities, and inspired by the success of bayesian networks in representing and reasoning about probabilities, we introduce the notion of utility distributions, in which utilities have the structure of probabilities. We furthermore define the notion of a bi-distribution, a structure that includes in a symmetric fashion both a probability distribution and autility distribution. We give several examples of bi-distributions. We also show that every state space with standard probability distribution and utility function can be embedded in a bi-distribution, and provide bounds on the size requirements of this bi-distribution. Finally, we suggest a reinterpretation of the von-Neumann and Morgenstern theorem in light of this new model.
Efficient 15N-13C Polarization Transfer by Third-Spin-Assisted Pulsed Cross-Polarization Magic-Angle-Spinning NMR for Protein Structure Determination.

We introduce a pulsed third-spin-assisted recoupling experiment that produces high-intensity long-range 15N–13C cross peaks using low radiofrequency (rf) energy. This Proton-Enhanced Rotor-echo Short-Pulse IRradiATION Cross-Polarization (PERSPIRATIONCP) pulse sequence operates with the same principle as the Proton-Assisted Insensitive-Nuclei Cross-Polarization (PAINCP) experiment but uses only a fraction of the rf energy by replacing continuous-wave 13C and 15N irradiation with rotor-echo 90° pulses. Using formyl-Met–Leu–Phe (f-MLF) and β1 immunoglobulin binding domain of protein G (GB1) as model proteins, we demonstrate experimentally how PERSPIRATIONCP polarization transfer depends on the CP contact time, rf power, pulse flip angle, and 13C carrier frequency and compare the PERSPIRATIONCP performance with the performances of PAINCP, RESPIRATIONCP, and SPECIFICCP for measuring 15N–13C cross peaks. PERSPIRATIONCP achieves long-range 15N–13C transfer and yields higher cross peak-intensities than that of th...
Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals

The hepatitis B virus (HBV) capsid or core protein (Cp) can self-assemble to form an icosahedral capsid. It is now being pursued as a target for small-molecule antivirals that enhance the rate and extent of its assembly to yield empty and/or aberrant capsids. These small molecules are thus called core protein allosteric modulators (CpAMs). We sought to understand the physical basis of CpAM-resistant mutants and how CpAMs might overcome them. We examined the effects of two closely related CpAMs, HAP12 and HAP13, which differ by a single atom but have drastically different antiviral activities, on the assembly of wild-type Cp and three T109 mutants (T109M, T109I, and T109S) that display a range of resistances. The T109 side chain forms part of the mouth of the CpAM binding pocket. A T109 mutant that has substantial resistance even to a highly active CpAM strongly promotes normal assembly. Conversely, a mutant that weakens assembly is more susceptible to CpAMs. In crystal and cryo-electron microscopy (cryo-EM) structures of T=4 capsids with bound CpAMs, the CpAMs preferentially fit into two of four quasi-equivalent sites. In these static representations of capsid structures, T109 does not interact with the neighboring subunit. However, all-atom molecular dynamics simulations of an intact capsid show that T109 of one of the four classes of CpAM site has a hydrophobic contact with the neighboring subunit at least 40% of the time, providing a physical explanation for the mutation's ability to affect capsid stability, assembly, and sensitivity to CpAMs.IMPORTANCE The HBV core protein and its assembly into capsids have become important targets for development of core protein allosteric modulators (CpAMs) as antivirals. Naturally occurring T109 mutants have been shown to be resistant to some of these CpAMs. We found that mutation of T109 led to changes in capsid stability and recapitulated resistance to a weak CpAM, but much less so than to a strong CpAM. Examination of HBV capsid structures, determined by cryo-EM and crystallography, could not explain how T109 mutations change capsid stability and resistance. However, by mining data from a microsecond-long all-atom molecular dynamics simulation, we found that the capsid was extraordinarily flexible and that T109 can impede entry to the CpAM binding site. In short, HBV capsids are incredibly dynamic and molecular mobility must be considered in discussions of antiviral mechanisms.
Ethnocentric Attitudes of American and International Students: Assessing the Impact of Collaboration

To compensate for measurement issues in previous studies and to further test the utility of the social contact hypothesis, this mixed-methods study compared ethnocentric attitudes of American and i...
Research on Dispatching Automation System Automatic Recognition Technology Based on Fuzzy Pattern Recognition Algorithm

W288 the development of automation, the dispatching automation system need to handle a large amount of messy signals. It is significant to ensure system stability by recognizing and classifying signals quickly and accurately. This paper introduces a learning algorithm based on the feature weight of CFuzziness function, which could solve dimension disaster problem of fuzzy C mean algorithm. By minimizing the function CFuzziness with the gradient descent algorithm, a proper weight value can be given to each feature, and the weighted fuzzy C mean algorithm is obtained. The results show that the clustering results of weighted fuzzy C mean algorithm are superior to the fuzzy C mean algorithm.
The role of narratives in human-environmental relations: an essay on elaborating win-win solutions to climate change and sustainability

In the context of sustainability and devising win-win solutions to socio-environmental challenges, this paper discusses various aspects of the fundamental role narratives play in grounding our values and institutions, impacting on our decisions and actions, and slowing down or accelerating change. Narratives are created to integrate particular events or trends in the worldview of the societies experiencing them. They anchor a linear story or timeline to underlying multidimensional “Gestalts” that characterize the society involved. Depending on the particular context involved, narratives can therefore “fix” existing assumptions, attitudes, and opinions, or they can open the way for change. When different narratives are conflated, results may emerge that have not been expected—as in the case of different perspectives on the relationship between humans and their environment. Narratives and the values they represent are articulated in the networks that each individual or group is part of. As such, they are at the root of the “imagined futures” that, according to Beckert, drive our societies’ economies. Changing narratives and thus changing imagined futures can transform ideas, attitudes, and institutions and are thus essential to effectuate societal change.
Analysis and Design of Coupled Inductive Bridges for Magnetic Sensing Applications

This paper presents the analysis and design of a novel magnetic sensor. We study the underlying physics of inductance shift sensors as a special case of the broader family of magnetic energy deviation sensors. The result is a quantitative definition of performance metrics with all assumptions and approximations explicitly stated. This analysis is then used to design a modified ac Wheatstone bridge that uses two inductor-pairs in a cross-coupled configuration, to half its size and double its transducer gain while maintaining a fully differential structure with a matched frequency response. A proof-of-concept sensor was fabricated with peripheral circuitry in a 65-nm bulk CMOS process to operate between 770 and 1450 MHz with an effective sensing area of 200 $\mu \text{m}\,\,\times $ 200 $\mu \text{m}$ . The new bridge sensor is fully characterized at a frequency of 770 MHz and demonstrates a reliable and continuous detection of 4.5- $\mu \text{m}$ iron-oxide magnetic beads over time periods longer than 30 min, appreciably longer than previously reported works.
Evaluation of 2-thiothiazolidine-4-carboxylic Acid, a Common Metabolite of Isothiocyanates as a Potential Biomarker of Cruciferous Vegetable Intake (P06-017-19)

Cruciferous vegetable consumption is associated with favorable health outcomes that are attributed to bioreactivity of isothiocyanates. These compounds exert effects that contribute to prevention of disease, in large part through attenuation of inflammation and oxidative stress. However, much about isothiocyanate metabolites and their role as biomarkers of crucifer intake remain unknown. In a clinical trial, we tested the utility and limitations of 2-thiothiazolidine-4-carboxylic acid (TTCA), an isothiocyanate-derived metabolite, as a urinary biomarker of broccoli beverage intake in a randomized crossover clinical trial where 50 participants consumed either a glucoraphanin-rich (GRR) or sulforaphane-rich (SFR) beverage. Compared to run-in and wash-out periods, we observed significantly higher urinary TTCA after broccoli beverage consumption. Measurements also showed that TTCA was present in beverage powders and in all tested cruciferous vegetables. GRR resulted in excretion of ∼87% of the ingested TTCA while SFR resulted in excretion of ∼176%. Elevated urinary TTCA was also observed in rats administered 100 µmol/kg sulforaphane (SFN). Unlike SFN, TTCA did not activate nuclear factor-like 2 (Nrf2)-mediated cytoprotective signaling. Collectively, TTCA appears to be a common isothiocyanate-derived metabolite that has the capacity to be utilized as a biomarker of cruciferous vegetables that would be beneficial for objective and quantitative tracking of intake in studies. Breast Cancer Research Foundation, NIH R35CA197222, R21AI122071, R01GM125944, R01DK112854, AHA17GRN33660955 and Chinese Medicine Science and Technology Research Foundation, Shandong Academy for Chinese Medicine 2015–317.
“Singultus” uncloaking potentially fatal vascular dissections

Aortic dissection (AD) is a serious condition in which the intimal layer of aorta tears and blood surges in between the intimal and medial layers of aorta causing it to separate (dissect). It usual...
Perceptions of the possible health and economic impacts of Seattle's sugary beverage tax.

Taxes on sugary beverages are an emerging strategy to improve health by reducing consumption and raising revenues to support community wellbeing. However, taxes may have unintended consequences, and perceptions of these consequences may affect attitudes towards this policy. In June 2017, the Seattle City Council passed an ordinance imposing a tax on sugary beverages, effective January 1, 2018. Between October and December 2017, we recruited 851 adults in Seattle to complete a survey (telephone or online) about support for the tax and their perceptions of tax-related health and economic impacts. We first analyzed data for the full sample. We then tested for differences in participants’ responses by household income level (< 260% Federal Poverty Level [FPL], ≥ 260% FPL) and across race/ethnicities using chi-square tests. Analyses used population weights and adjusted for multiple comparisons, using the Holm-Bonferroni Sequential Correction (p < 0.01). A majority of participants supported the sugary beverage tax (59%; 95% Confidence Interval [CI]: 55, 63%) and believed that the tax would improve public health (56%; CI: 52, 60%). Most participants believed that the tax would not negatively affect small businesses (52%; CI: 48, 56%) nor result in job loss (66%; CI: 62, 70%). Most participants also perceived that the tax would not negatively impact their own finances (79%; CI: 75, 82%). However, fewer lower-income (48%; CI: 42, 53%), versus higher-income participants (61%; CI: 55, 66%), perceived that the tax would improve public health, would not result in job loss (lower-income: 58%; CI: 53, 64%; higher-income: 71%; CI: 66, 75%) and would not negatively affect their own finances (lower-income: 68%; CI: 62, 73%; higher-income: 85%; CI: 81, 88%). Compared to non-Hispanic Whites, (82%; CI: 79, 86%), a smaller proportion of non-Hispanic Blacks (63%; 95% CI: 48, 75%), and Hispanics (67%; 95% CI: 51, 79%), perceived that the tax would have negative consequences for their own family finances. A majority of respondents supported the sugary beverage tax in Seattle. Lower-income participants were more concerned about potential financial consequences. Further evaluation of the extent to which unintended consequences occur is needed.
Advantages, Problems, and Growth Opportunities for Consumer Cooperatives: Consumer Attitudes vs. Co-OP Managers’ Opinions

This paper examines the attitudes of the consuming public as well as the opinions of co-op management concerning current practices and the future growth potential of co-ops. Results indicated that significant differences occurred between co-op managers and consumers concerning their opinions on advantages, problems, and opportunities for growth of co-ops.
Traffic conflicts as crash surrogates

Abstract A traffic conflict is defined as etiologically connected to a crash through a failure that causes the conflict, and the inevitability of crash if a correction is not made. Other definitions of conflict proposed over the years include the presence of failure-free aggressive behaviors. The proposed modification strengthens the causal relationship between conflict and crash as understood in the light of counterfactual analysis and Pearl's work on causality. Measures of crash nearness discussed in this chapter include time to collision, instantaneous time to collision, and post-encroachment time. A small separation between road users moving along conflicting paths and the necessity of an evasive maneuver are conditions for a traffic event to be a conflict.
Management of Induced Hypothermia in the Intensive Care Unit

The use of hypothermia as a therapeutic modality for preventing secondary brain damage in traumatic brain injury, global brain ischemia, and stroke remains controversial. However, hypothermia has been shown to help in control of raised intracranial pressure after traumatic brain injury in multiple centers. In this chapter we describe the management of induced hypothermia in the traumatic brain-injured patient in the intensive care unit. Several ways of inducing hypothermia in the severely head-injured patient are discussed. Risks and benefits of hypothermia in general, as well as in relation to the method used to induce the hypothermia, are discussed. Furthermore, the required monitoring that is necessary to detect and reduce potential harmful side effects induced by the hypothermia is described. Duration and the rewarming period are discussed. The need for new trials in which different devices are tested against one another are necessary to further evaluate their usefulness in the intensive care unit setting. Also, the effect on final outcome of the different methods should be evaluated. Finally, future directions for the application of hypothermia in brain protection are suggested.
"EVERY WORD YOU JUST SAID IS WRONG": ONLINE RAGE AND INCLUSIVITY IN DISNEY FRANCHISE FANDOM

The months leading up to the release of Disney franchise films The Last Jedi (December 2017) and Black Panther (February 2018) were marked by speculation, concern, and fervor in equal measures from the established fan communities of Star Wars and Marvel. Both franchises have been associated with toxic geek masculinity, a performed, communal hypermasculinity marked by exclusionary practices and rhetoric (Salter & Blodgett, 2017). By centering either non-white or non-male characters as leads in roles traditionally dominated by cisgender white men, both films became centers for toxic discourse and targeted campaigns aimed at disrupting their commercial success. In this paper, we will situate these case studies as emblematic of the changing discourse of geek fandom spaces, and its intersections with white supremacy and misogyny.
The Spine Physical Examination Using Telemedicine: Strategies and Best Practices.

Study Design:Technical note.Objectives:To provide spine surgeons new to telemedicine with a structured physical examination technique based on manual motor testing principles.Methods:Expert experie...
TESTING ECONOMIC MODELS OF DISCRIMINATION IN CRIMINAL JUSTICE

In this paper I derive several straightforward restrictions imposed by the Becker model of discrimination in the highway search and pre-trial release contexts. I explain how these restrictions may be tested using real-world data at the decision level (e.g., whether to search or whether to release a defendant). I then apply one of these restrictions to Florida data used in Anwar & Fang's (2006) influential study and more recent data from Harris County, Texas, provided by the Stanford Open Policing Project. The Florida data pass the restriction, but the Harris County data do not, with obvious implications for the appropriateness of the Becker model in each context. Further, data from both locations powerfully reject the prediction, from Knowles, Persico & Todd's (2001, KPT) two-sided model, that drivers will carry contraband at identical rates. Next I apply the Becker model restrictions to published estimates from Arnold, Dobbie & Yang's (2018) influential study of racial discrimination and pre-trial release. Their published estimates starkly violate the Becker model's restrictions, regardless of whether these are viewed as flowing from animus or inaccurate stereotyping. It is unclear whether the culprit is econometric assumptions, a failure of the Becker model, or both. These findings suggest the importance of specifi cation testing when we attempt to measure racial discrimination. They also suggest the need to consider alternatives to the workhorse Becker model, although doing so is beyond the scope of this paper.
Connecting Native Students to STEM Research Using Virtual Archaeology: A Case Study from the Water Heritage Anthropological Project

Universities struggle to provide meaningful education and mentorship to Native American students, especially in STEM fields such as archaeology and geography. The Native American Summer Mentorship Program (NASMP) at Utah State University is designed to address Native student retention and representation, and it fosters collaboration between mentors and mentees. In spring 2020, as university instruction went online due to the COVID-19 pandemic, NASMP mentors were faced with adapting hands-on activities and face-to-face interaction to an online format. Using our Water Heritage Anthropological Project as a case study, we show how virtual archaeological, archival, spatial, and anthropological labs can be adapted for online delivery. This approach may be especially useful for reaching students in rural settings but also for engaging students in virtual or remote research in the field sciences.
Live Coding: A Review of the Literature

One of the goals of computing education research is to document the potential strengths and weaknesses of contemporary teaching methods in computing. Live coding has recently gained attention as one of the best practices for teaching programming. To offer a more comprehensive understanding of the existing body of research about live coding, we reviewed papers in computing education research that investigated the value of live coding in an educational setting. We categorized each paper based on (1) how it defines live coding, (2) whether its version of live coding could be considered active learning, (3) the type of study conducted, (4) types of data collected and the data analysis methods used, (5) evidence provided for the effectiveness of live coding, (6) reported benefits and drawbacks of live coding, and (7) reported theoretical frameworks used to explain the basis, effects or goals of live coding. We found that although live coding has been recommended as one of the best practices for teaching programming, there is a lack of empirical evidence to support claims about the effectiveness of live coding on student learning. Finally, we discuss the implications of our findings and suggest future research directions that could develop a more holistic understanding of this pedagogical technique.
Scoring Running Records: Complexities and affordances:

Running Records are thought to be an excellent formative assessment tool because they generate results that educators can use to make their teaching more responsive. Despite the technical nature of...
Risk Evaluation of Unbound Pavement Layers to Extreme Weather Events Using Remote Sensing

The resilience of transportation infrastructure during and after extreme weather events, such as flash floods, sea-level rise, and hurricanes, is critical. A disruption in transportation and road networks during and after such events can delay emergency services and may disrupt the evacuation process. Studying the resilience of the transportation networks with a comprehensive data source can enhance the resiliency of infrastructure and assess the risks associated with a natural disaster. In this study, open-source satellite observations were used to investigate the impact of Hurricane Harvey on the performance of the pavement network in the State of Texas in 2017. Using volumetric moisture content, the environmental stress factor was calculated before, during, and after the hurricane to estimate the changes in the strength of geomaterial pavement layers. A preliminary risk assessment parameter was developed to evaluate and compare the resiliency of roads in the network. The results of this study can be further extended to other coastal regions with the incorporation of more in situ data and an extended version of the risk factor.
Leak: Why Mark Felt Became Deep Throat. By Max Holland. (Lawrence, KS: University Press of Kansas, 2012. Pp. xiii, 285. $29.95.)

The author, an independent journalist, tells several stories in this volume. For Watergate buffs, he offers a minutely detailed account of the Federal Bureau of Investigation's (FBI) investigation ...
The origins of maize genetics

Early geneticists, and generations since, have been drawn to maize to study basic questions, its curious phenomena and its practical applications. Part of the allure of this unique crop plant lies in the collegiality of the Maize Genetics Cooperation, extending all the way from the 'roaring twenties' of genetics to today.
The significance of blood cultures positive for emerging saprophytic moulds in cancer patients.

ABSTRACT The significance of blood cultures positive for emerging saprophytic moulds (e.g., Scedosporium apiospermum, Scedosporium prolificans, Paecilomyces spp.) was evaluated in 30 cancer patients (1996–2002). Diagnostic criteria proposed previously for evaluation of aspergillaemia were used. Blood cultures positive for emerging saprophytic moulds represented 1% of all positive fungal cultures. One case of catheter-related fungaemia was excluded. The remaining 29 cases consisted of true ( n = 5), probable ( n = 1), indeterminate ( n = 7) fungaemia, and contamination ( n = 16). True fungaemia was seen only in leukaemia patients and allogeneic bone marrow transplant recipients. S. apiospermum and S. prolificans were the commonest causes of true fungaemia.
Oculoplastic Surgery: review 2

A useful new text had been added to the compendium of the oculoplastics library with the publication of this volume. The author’s intent, as stated in the preface, was to provide a pragmatic approach to diagnosis and management of patients with a myriad of oculoplastic, orbital, and lacrimal conditions. This book accomplishes the goal of broadly covering many salient topics within the field of oculoplastics. The author divides the book into …
Current Disease and Epidemiologic Problems: What’s Hot?

Included among the many current world problems are viral diseases of considerable significance and threat. This talk could not possible cover them all but will discuss the emergence of Middle East respiratory syndrome in Saudi Arabia and nearby countries, ebolavirus hemorrhagic fever in West Africa, chikungunya in the Western Hemisphere, and the re-emergence of poliomyelitis.
Induction of CD44 cleavage in articular chondrocytes

Objective The hyaluronan receptor CD44 provides chondrocytes with a mechanism for sensing and responding to changes in the extracellular matrix. The purpose of this study was to document the fragmentation and loss of CD44 and to determine the likely mechanisms involved.
Scaling flow path processes to fluvial landscapes: An integrated field and model assessment of temperature and dissolved oxygen dynamics in a river‐floodplain‐aquifer system

[1] Biogeochemical cycling within river ecosystems is strongly influenced by geomorphic and hydrologic dynamics. To scale point observations of temperature and dissolved oxygen (DO) to a hydrologically complex and dynamic three-dimensional river-floodplain-aquifer system, we integrated empirical models of temperature and biotic oxygen utilization with a recently published hydrogeomorphic model. The hydrogeomorphic model simulates channel flow, floodplain inundation, and surface-subsurface water exchange on the 16 km2 Nyack Floodplain, Middle Fork Flathead River, Montana, USA. Model results were compared to observed data sets of DO to test the hypothesis that complexity in spatiotemporal patterns of biogeochemistry emerges from a comparatively simple representation of biogeochemical processes operating within a multidimensional hydrologic system. The model explained 58% of the variance in 820 DO measurements that spanned the study site longitudinally, laterally, vertically, and across river discharge conditions and seasons. We also used model results to illustrate spatial and temporal trends of temperature and DO dynamics within the shallow alluvial aquifer, which is an extensive hyporheic zone because subsurface alluvial flow paths are recharged primarily by channel water. Our results underscore the importance of geomorphic, hydrologic, and temperature dynamics in driving river ecosystem processes, and they demonstrate how a realistic representation of a river's physical template, combined with simple biogeochemical models, can explain complex patterns of solute availability.
Paleointensity of the Earth's magnetic field using SQUID microscopy

Knowledge of the paleointensity of magnetic fields is valuable for our understanding of the origin and evolution of planetary dynamos and the history of planetary interiors. Until recently, quantitative paleomagnetic and paleointensity analyses were limited to magnetometry of bulk samples. The most sensitive of these moment magnetometers use superconducting quantum interference devices (SQUIDs), which measure the net moment of samples typically millimeters to centimeters in size with sensitivities of 10 −9 Am 2 . Recently, SQUIDs have been adapted to map the fine-scale magnetic fields of geological thin sections with unprecedented spatial resolutions of better than 100 μm and moment sensitivities better than 10 −15 Am 2 . Here we present a detailed study of the magnetization within basalts from the Hawaii Scientific Drilling Project using SQUID microscopy and moment magnetometry in combination with borehole magnetometry, petrographic and geologic data. We demonstrate how SQUID microscopy can be used to measure the paleointensity of the Earth's field which magnetized these basalts during the last 500 ky. These experiments are the first time alternating field demagnetization and paleointensity experiments have been conducted on natural remanent magnetization using submillimeter magnetic imaging techniques. Our high resolution field maps enable us to make thousands of paleointensity measurements on a single thin section which can be correlated with the minerals, petrologic textures, and alteration zones within the samples. © 2007 Elsevier B.V. All rights reserved.
Effect of degree of encapsulation upon virulence of Cryptococcus neoformans.

SummaryThinly encapsulated Cryptococcus neoformans cells were equally as virulent for white Swiss mice as thickly encapsulated cells of the same strain. Yeast cells initially possessing thin capsules promptly developed thick ones upon intracerebral injection into mice, and upon subculture to synthetic capsule medium. Both types of cells produced hydrocephalus to an equal degree. Degree of encapsulation is not a factor in virulence of Cryptococcus neoformans for white Swiss mice.
The market for illicit monopoly: Its implication for social welfare

In this paper, the market for illicit monopoly was formulated and the corresponding measure of the social cost of any observed monopoly was derived. It was shown that if the potential for successful monopoly is known (although not necessarily with certainty), if the property rights to monopoly profits are defined ex-ante, and if the analysis is viewed ex-ante to the existence of monopoly, then the social cost of any observed monopoly is the Harberger triangle plus some portion of monopoly profits. If it is attained unexpectedly and costlessly or if the economic analysis is performed after the existence of the monopoly, then the social cost of monopoly is largely confined to the Harberger triangle.
Use of treated mine water for rainbow trout (Oncorhynchus mykiss) culture: a production scale assessment

Abstract In previous proof-of-concept work, it was shown that the use of treated coal mine water for rainbow trout ( Oncorhynchus mykiss ) culture in a cage was technically feasible, though only a 50-fish bioassay was grown and no work on production-related issues was conducted. To further advance the use of treated mine water, an under-utilized water resource throughout Mid Appalachia, work was conducted to assess the effects of using treated coal mine water for the intensive production of rainbow trout in a flow-through system. During this study, comprehensive water quality data were collected to supplement fish weight and length data taken during routine monthly sampling events. The 8000 fish grew well in the raceway system over the 9 months of production, where a feed conversion ratio of 1.4 and a condition factor of 5.1 × 10 −4 were measured with stocking and harvest densities of 26.4 and 50.2 kg/m 3 , respectively. Further, total net production was 3275 kg (7220 lb) with 98.6% survival. Throughout the study, dissolved ion concentrations (Fe, Al, Mg, Ca, and SO 4 ) often exceeded recommended tolerance limits. Further, elevated ammonia nitrogen concentrations generated from a component of the mine water-treatment process were identified as a potential limiting factor for aquaculture development. However, when the non-ideal effects of high ionic strength and the speciation of dissolved metal–ligand complexes were taken into account, the concentrations of free metal ions were within recommended tolerance limits.
The Effects of Organizational Restructuring on Frames of Reference and Cooperation

Organizational researchers have distinguished between first order change (improvements within already acceptedframeworks) and second order change (discontinuous shifts in frameworks). These types of change, when assessed quantitatively, have been labeled "alpha" and "'gamma" change. The study reported in this paper investigated an organizational restructuring attempt to achieve a first order (alpha) increase in cooperation and a second order (gamma) change in organization members' understanding of factors associated with importance in the organization. The restructuring process studied was an internal merger in a religious order. Results of confirmatory factor analysis indicated that both types of change occurred.
A locally conservative stress recovery technique for continuous Galerkin FEM in linear elasticity

Abstract The standard continuous Galerkin finite element method (FEM) is a versatile and well understood method for solving partial differential equations. However, one shortcoming of the method is lack of continuity of derivatives of the approximate solution at element boundaries. This leads to undesirable consequences for a variety of problems such as a lack of local conservation. A two-step postprocessing technique is developed in order to obtain a local conservation from the standard continuous Galerkin FEM on a vertex centered dual mesh relative to the finite element mesh when applied to displacement based linear elasticity. The postprocessing requires an auxiliary fully Neumann problem to be solved on each finite element where local problems are independent of each other and involve solving two small linear algebra systems whose sizes are 3-by-3 when using linear finite elements on a triangular mesh for displacement based linear elasticity. The postprocessed stresses then satisfy local conservation on the dual mesh. An a priori error analysis and numerical simulations are provided.
Euryhaline adaptations in the fat sleeper, Dormitator maculatus

Salinity tolerances and plasma osmotic concentrations were determined in the fat sleeper, Dormitator maculatus, a common species in estuarine and coastal fresh waters along the Atlantic and Caribbean coasts of North, Central and South America. Analyses followed sequential laboratory acclimations to a series of ambient salinities at a constant temperature of 20 ± 1° C and photoperiod of 12L: 12D. These fish tolerated a range of ambient salinities from fresh water through a salinity of 75‰. Plasma osmotic concentrations were regulated at an essentially constant level in the salinity range from fresh water through a salinity of 50‰, beyond which plasma concentrations trended upward with increased ambient salinity. We conclude that D. maculatus, while truly euryhaline, docs not show the extreme euryhalme capabilities of several teleost fishes that are ‘full-time’ estuarine inhabitants.