cssi/SciSciGPT-SciSciNet huggingface dataset:
Capacity for Statewide Implementation of Positive Behavior Supports A Needs Assessment Strategy

This article describes an assessment process of the statewide capacity for integrating positive behavior supports (PBS) into the policies and practices of service delivery systems that provide support for individuals with developmental disabilities who present challenging behaviors. A multicomponent needs assessment process was conducted to determine the capacity of systems in the Commonwealth of Virginia that provide services to individuals who present challenging behaviors. The process was designed to use a seven-step procedure incorporating qualitative and quantitative data collection strategies. Three interrelated studies were conducted to assess the use of PBS and PBS-related training needs across Virginia's service delivery systems (i.e., early intervention, school, and adult). Results of these studies indicate a need for comprehensive training, refresher training, and improved collaboration among providers across Virginia's service delivery systems.
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro. Remarkably, the site of p53 that is acetylated by its coactivator, p300, resides in a C-terminal domain known to be critical for the regulation of p53 DNA binding. Furthermore, the acetylation of p53 can dramatically stimulate its sequence-specific DNA-binding activity, possibly as a result of an acetylation-induced conformational change. These observations clearly indicate a novel pathway for p53 activation and, importantly, provide an example of an acetylation-mediated change in the function of a nonhistone regulatory protein. These results have significant implications regarding the molecular mechanisms of various acetyltransferase-containing transcriptional coactivators whose primary targets have been presumed to be histones.
The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin-sensitive pathways

Somatostatin exerts multiple effects throughout the body by binding to specific somatostatin receptors. Two classes of somatostatin receptors, SRIF1 and SRIF2, have been distinguished biochemically and pharmacologically. Two cDNAs have been recently isolated that encode somatostatin receptors 1 and 2 (SSTR1 and SSTR2, respectively). The pharmacological characteristics of receptors expressing these cDNAs resemble those of the SRIF2 and SRIF1 classes of somatostatin receptors, respectively. We stably expressed the rat homologs of both receptors in Chinese hamster ovary (CHO) cells (type K1). These transfected cell lines recognized the endogenous ligands SS14 and SS28 with high affinity, whereas the synthetic analog MK678 identified only SSTR2. In preparations of CHO-SSTR1 or CHO-SSTR2 cells, SS14 and SS28 inhibited forskolin-stimulated adenylyl cyclase activity by approximately 35%, with ED50 values in the nanomolar range. The adenylyl cyclase inhibition was dependent upon the guanine nucleotide GTP and cou...
discourse genres in a theory of practice

In order to analyze language use within a theory of social practice, it is necessary to develop a coherent approach to speech genres. This paper contributes to such an approach, by treating genres as elements of linguistic habitus, consisting of stylistic, thematic, and indexical schemata on which actors improvise in the course of linguistic production. The empirical focus is “official” Maya language documents produced in 16th-century colonial Yucatan. The rise of novel discourse genres in colonial society was part of the emergence of new, hybrid forms of action. [Mesoamerica, Maya, discourse analysis, social practice]
Effect of Untreated Surface Disbonds on Performance of FRP-Retrofitted Concrete Beams

Retrofitting concrete structures with externally bonded fiber-reinforced polymer (FRP) laminates has become an increasingly common practice. Disbonds at the concrete-FRP interface, if left untreated, may adversely affect the performance of the retrofitted system. Disbonds in the form of surface voids and cracks are the subject of this paper. Voids may occur due to poor compaction or defective formwork, or in the form of air entrapment between resin and FRP laminate during application. Cracks, on the other hand, generally result from loading. This study is comprised of a detailed experimental program and a nonlinear finite-element analysis. In the experiments, surface cracks were simulated by cutting slits in concrete, herein termed as surface cuts. The study shows that leaving surface disbonds untreated, within the considered range of disbond variables, does not have a significant impact on the overall structural performance. A threshold of 12.7 mm for void diameter was deemed conservative for structural ...
Autonomic nervous system function among individuals with acute musculoskeletal injury.

Objective To determine differences in peripheral and cardiovascular autonomic function between individuals with acute musculoskeletal injury ( Methods Autonomic cardiovascular modulation, baroreceptor sensitivity, skin conductance, and peripheral skin temperature were obtained in 6 subjects with acute musculoskeletal injury and 6 age- and sex-matched controls. Power spectral analysis was performed on both beat-to-beat R-R intervals and continuous systolic blood pressure (SBP) peaks. Baroreceptor sensitivity was derived using both heart rate and blood pressure spectral analysis components. Results The SD of R-R intervals was significantly different for the acute injury group relative to controls (49.8 ± 10.5 vs 76.8 ± 12.7 ms; P 2 /Hz, and 3.87 ± 1.04 vs 2.19 ± 0.3 mhos; P P r = 0.75; P Conclusions These findings suggest that interaction between cutaneous and vasomotor sympathetic neurons in response to acute musculoskeletal injury, reflected as increased afferent input from sensitized nociceptors and other sensory neurons, results in alterations in autonomic function.
Nucleotide-Dependent Movements of the Kinesin Motor Domain Predicted by Simulated Annealing

The structure of an ATP-bound kinesin motor domain is predicted and conformational differences relative to the known ADP-bound form of the protein are identified. The differences should be attributed to force-producing ATP hydrolysis. Candidate ATP-kinesin structures were obtained by simulated annealing, by placement of the ATP gamma-phosphate in the crystal structure of ADP-kinesin, and by interatomic distance constraints. The choice of such constraints was based on mutagenesis experiments, which identified Gly-234 as one of the gamma-phosphate sensing residues, as well as on structural comparison of kinesin with the homologous nonclaret disjunctional (ncd) motor and with G-proteins. The prediction of nucleotide-dependent conformational differences reveals an allosteric coupling between the nucleotide pocket and the microtubule binding site of kinesin. Interactions of ATP with Gly-234 and Ser-202 trigger structural changes in the motor domain, the nucleotide acting as an allosteric modifier of kinesin's microtubule-binding state. We suggest that in the presence of ATP kinesin's putative microtubule binding regions L8, L12, L11, alpha4, alpha5, and alpha6 form a face complementary in shape to the microtubule surface; in the presence of ADP, the microtubule binding face adopts a more convex shape relative to the ATP-bound form, reducing kinesin's affinity to the microtubule.
Validation of Spot screening device for amblyopia risk factors

Purpose To validate the Spot Vision Screener, a handheld digital screening device that evaluates children for amblyopia risk factors as defined by 2013 criteria of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS), in the setting of a controlled pediatric ophthalmology clinic. Methods During a 3-month period, children 2-9 years of age were screened using Spot in a pediatric ophthalmology clinic before receiving a gold standard eye examination. Gold standard examinations were evaluated using the 2013 AAPOS Vision Screening Committee guidelines and compared with results from Spot, which were evaluated using two different manufacturer referral criteria: v1.0.3 and v1.1.51. The specificity and sensitivity for each set of referral criteria to detect both amblyopia risk factors and amblyopia were calculated. Results A total of 233 children were included. Of these, 155 were successfully screened and analyzed according to two different referral criteria. Spot screeing revealed ambyopia risk factors in 109 patients; examination confirmed amblyopia in 64. Using the original manufacturer's criteria (v1.0.3), Spot was 89% sensitive and 71% specific in detecting amblyopia risk factors. The updated referral criteria (v1.1.51) were applied to the same 155 patients, and specificity improved to 88% ( P P Conclusions The Spot-v1.0.3 had high sensitivity but overreferred for suspected myopia and strabismus; Spot-v1.1.51 maintained high sensitivity and improved specificity. The original referral criteria has a high sensitivity to detect amblyopia risk factors but low specificty; v1.1.51 criteria increases specificity with minimal impact on sensitivity.
Perceived importance of occupations by adolescents with and without learning disabilities.

A study of the perceived importance of 23 occupations by 65 adolescents with learning disabilities and 85 adolescents without learning disabilities revealed that occupations were ranked similarly by the two groups (Rho = .76). Analysis of the groups' rank order indicated diversity of students' perceptions about the importance of various occupations.
Uses and Misuses of Bronfenbrenner's Bioecological Theory of Human Development

This paper evaluates the application of Bronfenbrenner's bioecological theory as it is represented in empirical work on families and their relationships. We describe the “mature” form of bioecological theory of the mid-1990s and beyond, with its focus on proximal processes at the center of the Process-Person-Context-Time model. We then examine 25 papers published since 2001, all explicitly described as being based on Bronfenbrenner's theory, and show that all but 4 rely on outmoded versions of the theory, resulting in conceptual confusion and inadequate testing of the theory.
Inherent rule variability in consumer choice: Changing rules for change's sake

The present research demonstrates that consumers tend to vary their use of decision rules independent of option and set characteristics. In five experiments, increased choice of a particular option (e.g., lower price, brand name, or compromise option) was associated with relatively decreased choice of that same (generic) option on occasions that followed. Results indicate that this inherent rule variability is not an effect of background contrast but instead relates to consumers' favorable valuation of decision change itself. This research implies that the idea of contingent decision making applies not only to decision outcomes but also to decision processes.
A fractionally spaced linear receive equalizer with voltage-to-time conversion

Based on voltage-to-time conversion technique, a pseudo-differential two-way-interleaved adaptive linear receive equalizer with two 2x-oversampled feed-forward taps has been designed in a 90 nm CMOS process. It integrates equalization and phase interpolation functions into one unit to simultaneously address inter-symbol-interference (ISI) cancellation and phase synchronization in a link receiver. It operates at 4 Gbps with 8 mW power consumption, and linearity of 4.3 effective bits at 1.2 V supply.
An analysis of police responses to gangs in Chicago

In response to Chicago’s well‐documented gang problem, the Chicago Police Department (CPD) established its first specialized gang unit in 1967. In the ensuing decades, the CPD reorganized its core gang unit several times and expanded its anti‐gang response through numerous supporting restructuring efforts. The Chicago experience indicates that reorganization can positively and negatively influence the relative effectiveness of the police response to gangs. As such, the lessons for police departments are twofold: be careful when restructuring, particularly when adapting for reasons not tied to the actual gang problem; but reorganize whenever necessary to address rising gang violence.
Intershield geochemical differences among Hawaiian volcanoes: implications for source compositions, melting process and magma ascent paths

As Hawaiian volcanoes develop, their lavas systematically change in composition and isotopic ratios of Sr, Nd and Pb. These trends provide important constraints for understanding plume-related volcanism as a volcano migrates away from the hotspot. There are also geochemical differences between Hawaiian shields. In particular, lavas from adjacent shields such as Kilauea and Mauna Loa on Hawaii and Koolau and Waianae on Oahu have significant differences in abundances of some major and incompatible elements and isotopic ratios of Sr, Nd and Pb. Some incompatible element abundance ratios, such as Zr/Nb and Sr/Nb, are correlated with intershield differences in Sr and Nd isotope ratios, but these isotopic ratios are not correlated with intershield differences in major element composition, or even parent/daughter abundance ratios such as Rb/Sr and Sm/Nd. Moreover, at Kilauea and Mauna Loa the intershield differences have apparently persisted for a relatively long time, perhaps 100 ka. These intershield geochemical differences provide important constraints on plume volcanism. Specifically, (i) each volcano must have distinct magma ascent paths from the region of melt segregation; (ii) the 25-50 km distance between adjacent, but geochemically distinct, shields requires that the sources vary on a similar scale, and that the melt production region is similarly restricted. The absence of correlations between lava compositions and radiogenic isotope ratios provides evidence for significant differences in melting process such as each shield forming by a different mean extent of melting with melt segregation at different mean pressures. Two types of models are consistent with the intershield geochemical differences: (i) a relatively large radius, ca. 40 km, plume conduit with a systematic spatial distribution of geochemical heterogeneities; or (ii) a small radius, less than 20 km, plume conduit composed of geochemically distinct diapirs. Because relatively small radius diapirs of limited vertical extent are too small to create the large Hawaiian shields, a possible alternative is a continuous conduit containing solitary waves which transport geochemically distinct packets of material.
Economic Development and Public Education: Strategies and Standards

Public discussion of public school reform has been animated by a popular presumption that public education is a key to economic development. The popular model further presumes that a direct and simple mechanism connects education and development. Review of a rapidly accumulating literature indicates that there is a strong connection, but the mechanisms are many and complex rather than few and simple. Three basic development strategies are identified and corresponding educational standards are defined as a way of simplifying a growing complexity confronting public decision makers. The strategy-standard pairs are termed the shifting foundation, high-performance applications, and innovation process.
The opioid renewal clinic: a primary care, managed approach to opioid therapy in chronic pain patients at risk for substance abuse.

Objective. To measure the impact of a structured opioid renewal program for chronic pain run by a nurse practitioner (NP) and clinical pharmacist in a primary care setting. Patients and Setting. Patients with chronic noncancer pain managed with opioid therapy in a primary care clinic staffed by 19 providers serving 50,000 patients at an urban academic Veterans hospital. Design. Naturalistic prospective outcome study. Intervention. Based on published opioid prescribing guidelines and focus groups with primary care providers (PCPs), a structured program, the Opioid Renewal Clinic (ORC), was designed to support PCPs managing patients with chronic noncancer pain requiring opioids. After training in the use of opioid treatment agreements (OTAs) and random urine drug testing (UDT), PCPs worked with a pharmacist-run prescription management clinic supported by an onsite pain NP who was backed by a multi-specialty Pain Team. After 2 years, the program was evaluated for its impact on PCP practice and satisfaction, patient adherence, and pharmacy cost. Results. A total of 335 patients were referred to the ORC. Of the 171 (51%) with documented aberrant behaviors, 77 (45%) adhered to the OTA and resolved their aberrant behaviors, 65 (38%) self-discharged, 22 (13%) were referred for addiction treatment, and seven (4%) with consistently negative UDT were weaned from opioids. The 164 (49%) who were referred for complexity including history of substance abuse or need for opioid rotation or titration, with no documented aberrant drug-related behaviors, continued to adhere to the OTA. Use of UDT and OTAs by PCPs increased. Significant pharmacy cost savings were demonstrated. Conclusion. An NP/clinical pharmacist-run clinic, supported by a multi-specialty team, can successfully support a primary care practice in managing opioids in complex chronic pain patients.
Cloudy with a Chance of Cost Savings

Cloud-based hosting is claimed to possess many advantages over traditional in-house (on-premise) hosting such as better scalability, ease of management, and cost savings. It is not difficult to understand how cloud-based hosting can be used to address some of the existing limitations and extend the capabilities of many types of applications. However, one of the most important questions is whether cloud-based hosting will be economically feasible for my application if migrated into the cloud. It is not straightforward to answer this question because it is not clear how my application will benefit from the claimed advantages, and, in turn, be able to convert them into tangible cost savings. Within cloud-based hosting offerings, there is a wide range of hosting options one can choose from, each impacting the cost in a different way. Answering these questions requires an in-depth understanding of the cost implications of all the possible choices specific to my circumstances. In this study, we identify a diverse set of key factors affecting the costs of deployment choices. Using benchmarks representing two different applications (TPC-W and TPC-E) we investigate the evolution of costs for different deployment choices. We consider important application characteristics such as workload intensity, growth rate, traffic size, storage, and software license to understand their impact on the overall costs. We also discuss the impact of workload variance and cloud elasticity, and certain cost factors that are subjective in nature.
Wind Speed Dependence of Single-Site Wave-Height Retrievals from High-Frequency Radars

Abstract Wave-height observations derived from single-site high-frequency (HF) radar backscattered Doppler spectra are generally recognized to be less accurate than overlapping radar techniques but can provide significantly larger sampling regions. The larger available wave-sampling region may have important implications for observing system design. Comparison of HF radar–derived wave heights with acoustic Doppler profiler and buoy data revealed that the scale separation between the Bragg scattering waves and the peak energy-containing waves may contribute to errors in the single-site estimates in light-to-moderate winds. A wave-height correction factor was developed that explicitly considers this scale separation and eliminates the trend of increasing errors with increasing wind speed.
New artificial neural net models: basic theory and characteristics

Models for feedback artificial neural nets (ANNs) which are shown to have qualitatively the same dynamic properties as gradient continuous-time feedback neural nets are presented. These models are based on biological neural nets where neurons have dendrodendritic connections i.e. where connections among neurons occur via dendrites only. These models have the maximum number of connections equal to n (n+1)/2, where n is the number of neurons. The synaptic weights are naturally symmetric. One model uses nonlinear weights are naturally symmetric. One model uses nonlinear floating MOSFET transistors for its dendritic connection, where its conductance is controlled via the gate voltage. This last model lends itself naturally to analog all-MOS VLSI implementation. >
An evaluation of statistical spam filtering techniques

This paper evaluates five supervised learning methods in the context of statistical spam filtering. We study the impact of different feature pruning methods and feature set sizes on each learner's performance using cost-sensitive measures. It is observed that the significance of feature selection varies greatly from classifier to classifier. In particular, we found support vector machine, AdaBoost, and maximum entropy model are top performers in this evaluation, sharing similar characteristics: not sensitive to feature selection strategy, easily scalable to very high feature dimension, and good performances across different datasets. In contrast, naive Bayes, a commonly used classifier in spam filtering, is found to be sensitive to feature selection methods on small feature set, and fails to function well in scenarios where false positives are penalized heavily. The experiments also suggest that aggressive feature pruning should be avoided when building filters to be used in applications where legitimate mails are assigned a cost much higher than spams (such as λ = 999), so as to maintain a better-than-baseline performance. An interesting finding is the effect of mail headers on spam filtering, which is often ignored in previous studies. Experiments show that classifiers using features from message header alone can achieve comparable or better performance than filters utilizing body features only. This implies that message headers can be reliable and powerfully discriminative feature sources for spam filtering.
Surface chlorophyll concentrations in relation to the Antarctic Polar Front: seasonal and spatial patterns from satellite observations

Satellite ocean color data from the Sea Viewing Wide Field of View Sensor (SeaWiFS) are used to investigate phytoplankton bloom dynamics at the Antarctic Polar Front (PF). Satellite sea surface temperature (SST) data are used to map the location of the PF at weekly timescales. Elevated chlorophyll within the PF often appears as a narrow band that occupies only a portion of the SST gradient across the PF. Phytoplankton blooms within the PF occur most frequently during the month of December and are unevenly distributed within the Southern Ocean. Elevated chlorophyll concentrations at the PF are most frequently observed where the current is interacting with large topographic features. Mesoscale physical processes, including meander-induced upwelling and increased eddy mixing, where the PF encounters large topographic features likely leads to increased nutrient flux to surface waters in these regions. The highest mean chlorophyll values associated with the PF occur where the front comes into contact with relatively shallow waters along the North Scotia Ridge and at Kerguelen Plateau. Iron input from sedimentary sources likely plays an important role in these regions. Over seasonal timescales it appears likely that light-limitation prevents phytoplankton blooms at the PF during winter and spring months. PF blooms are observed most commonly during December when surface radiation peaks and mixed layer depths are rapidly shoaling. Even during December, when the light regime would seem to be favorable, PF blooms are largely restricted to regions where enhanced nutrient fluxes to surface waters due to frontal dynamics are likely. During late summer, nutrient limitation due to depletion of iron and possibly silicate largely prevent blooms at the PF. In the fall, deepening mixed layers would provide some relief from nutrient limitation but likely lead again to light-limitation of growth rates and the prevention of blooms. D 2002 Elsevier Science B.V. All rights reserved.
Polymer Networks with Grafted Cell Adhesion Peptides for Highly Biospecific Cell Adhesive Substrates

Polymer networks of poly(ethylene glycol) (PEG) in densely cross-linked matrices of acrylic acid (AA) and trimethylolpropane triacrylate were synthesized as biospecific cell adhesive substrates. Networks grafted with synthetic adhesion peptides produced substrates to investigate long-term, receptor-mediated cell/surface interactions, without nonspecific protein adsorption producing spurious adhesion signals. PEG rendered the networks very resistant to cell adhesion in vitro, and AA provided reactive carboxyl moieties for N-terminal grafting of peptides. Networks with higher mass fractions of AA had greater background cell adhesion, which diminished with higher mass fractions of PEG such that complete resistance to cell adhesion could be obtained. Networks grafted with inactive control peptides (GRGES or no peptide) remained completely cell nonadhesive in the presence of serum or even when preincubated with adhesion proteins, while networks grafted with bioadhesive peptides (GRGDS, GYIGSRY, or GREDVY) supported morphologically complete fibroblast adhesion. The amount of AA in the network readily controlled the amount of incorporated peptide. These networks may be suitable as analytical tools specifically to investigate long-term cell/substrate interactions in the presence of serum, yet without non-specific protein adsorption producing adhesion signals other than those immobilized for study. [on SciFinder (R)]
Collagen mimetic peptides: progress towards functional applications

Traditionally, collagen mimetic peptides (CMPs) have been used for elucidating the structure of the collagen triple helix and the factors responsible for its stabilization. The wealth of fundamental knowledge on collagen structure and cell–extracellular matrix (ECM) interactions accumulated over the past few decades has led to a recent burst of research exploring the potential of CMPs to recreate the higher order assembly and biological function of natural collagens for biomedical applications. Although a large portion of such research is still at an early stage, the collagen triple helix has become a promising structural motif for engineering self-assembled, hierarchical constructs similar to natural tissue scaffolds which are expected to exhibit unique or enhanced biological activities. This paper reviews recent progress in the field of collagen mimetic peptides that bears both direct and indirect implications to engineering collagen-like materials for potential biomedical use. Various CMPs and collagen-like proteins that mimic either structural or functional characteristics of natural collagens are discussed with particular emphasis on providing helpful information to bioengineers and biomaterials scientists interested in collagen engineering.
The effect of changes in health beliefs among African-American and rural white church congregants enrolled in an obesity intervention : a qualitative evaluation.

Church interventions can reduce obesity disparities by empowering participants with knowledge and skills within an established community. The purpose of this study was to evaluate the Biomedical/Obesity Reduction Trial (BMORe) and investigate changes in health beliefs among obese adult participants. Ten pre-/post-intervention focus groups applying the Health Belief Model conducted in two African-American churches in Tennessee (n = 20) and South Carolina (n = 20), and one rural Appalachian church in Kentucky (n = 21). Two independent coders using NVivo analyzed transcribed audio data and notes. Participants' health status of being overweight/obese and having comorbidities of diabetes and high blood pressure motivated enrollment in BMORe. Initially participants voiced low self-efficacy in cooking healthy and reading food labels. BMORe made participants feel "empowered" after 12 weeks compared to initially feeling "out of control" with their weight. Participants reported improvements in emotional health, quality of life, and fewer medications. During post-intervention focus groups, participants reported increased self-efficacy through family support, sharing healthy eating strategies, and having accountability partners. Solidarity and common understanding among BMORe participants led focus group attendees to comment how their peers motivated them to stay in the program for 12 weeks. Long-term barriers include keeping the weight off by maintaining habits of exercise and healthy eating. Implementation of pre-/post-intervention focus groups is an innovative approach to evaluate an obesity intervention and track how changes in health beliefs facilitated behavior change. This novel approach shows promise for behavioral interventions that rely on participant engagement for sustained effectiveness.
Some Classical Interpolation Problems

In this chapter we will use the commutant lifting theorem with the functional model S(m) to solve the Caratheodory, Nevanlinna-Pick, and Hermite-Fejer interpolation problems. Besides this we will present the natural connection between Hermite-Fejer interpolation theory and contractive Hankel operators with rational symbols. In particular, we will solve the Nehari H∞ optimization problem for rational symbols by Hermite-Fejer interpolation. Also we will show how the Hankel operator in the Nehari optimization problem can be used in Hermite-Fejer interpolation. Furthermore we will present state space realization methods for solving the Nehari H∞ optimization problem with rational symbols Finally, we present a Schur-Cohn test based on Hankel operators, and give a geometric interpretation of the norm of Hankel operators with rigid rational symbols.
Bio-inspired fluidic thermal angular accelerometer

This paper reports on a bio-inspired angular accelerometer based on a two-mask microfluidic process using a PDMS mold. The sensor is inspired by the semicircular canals in mammalian vestibular systems and pairs a fluid-filled microtorus with a thermal detection principle based on thermal convection. With inherent linear acceleration insensitivity, the sensor features a sensitivity of 29.8μV/deg/s2=1.7mV/rad/s2, a dynamic range of 14,000deg/s2 and a detection limit of ∼20deg/s2
The Courtship and Copulation of Pasimachus punctulatus Haldemann (Coleoptera: Carabidae)

On July 9, 1957, while collecting at night with a headlamp in a ridge-top oak-hickory forest in Hocking County, Ohio, I observed the courtship and copulation of the large ground beetle, Pasimachus punctulatus Haldemann. Owing to the paucity of records concerning such observations and the increasing significance of behavior patterns associated with reproduction in insects—in species recognition as well as in evolutionary and comparative studies—the information seems worth recording.
Italian Echoes in Albert Camus: Two Notes on La Chute I. Dante in Amsterdam

(1958). Italian Echoes in Albert Camus: Two Notes on La Chute I. Dante in Amsterdam. Symposium: A Quarterly Journal in Modern Literatures: Vol. 12, No. 1-2, pp. 65-79.
Biliary excretion of vincristine

A patient with pancreatic carcinoma and a choledochal T tube was given tritiated vincristine sulfate ([3H]-VCR) intravenously. Peak biliary excretion occurred in 2 to 4 hr and this sample contained 9.7% of the injected radioactivity. The first 24-hr bile sample contained 21.7% of the dose and 76.4% of the cumulative 72-hr biliary excretion. During a 3-day period of observation, 4.2%, 45.6%, and 49.6% of the excreted radiolabel was present in the feces, urine, and bile, respectively. Products of VCR metabolism and decomposition appeared in the bile rapidly; only 46.5% of the drug was present in the parent form in the 2-hr collection. Since significant amounts of these products were also identified in control specimens of bile, blood, plasma, and buffer alone after brief periods of incubation, the origin and nature of the species appearing in the bile remain unclear. Observing the fecal route to be the major source of elimination of radiolabel following intravenous injection of [3H]-VCR in our patients previously, we now conclude the biliary system to be the principal route of excretion of VCR and its products. Hepatic dysfunction might therefore alter elimination kinetics and increase the exposure to VCR and its products which might augment toxicity and require dose modification.
High-Efficiency Thermoelectrics with Functionalized Graphene

Graphene superlattices made with chemical functionalization offer the possibility of tuning both the thermal and electronic properties via nanopatterning of the graphene surface. Using classical and quantum mechanical calculations, we predict that suitable chemical functionalization of graphene can introduce peaks in the density of states at the band edge that result in a large enhancement in the Seebeck coefficient, leading to an increase in the room-temperature power factor of a factor of 2 compared to pristine graphene, despite the degraded electrical conductivity. Furthermore, the presence of patterns on graphene reduces the thermal conductivity, which when taken together leads to an increase in the figure of merit for functionalized graphene by up to 2 orders of magnitude over that of pristine graphene, reaching its maximum ZT ∼ 3 at room temperature according to our calculations. These results suggest that appropriate chemical functionalization could lead to efficient graphene-based thermoelectric m...
Heterogeneous Effects of Child Development Accounts on Savings for Children’s Education

ABSTRACTWe examine effects of Child Development Accounts on savings for postsecondary education in a statewide experiment (N = 2,677), which automatically opened state-owned college savings accounts for treatment-group children, and encouraged their caregivers to open and save in participant-owned college savings accounts. The experiment achieves universal participation for children in the treatment group; almost all treatment-group children hold an account with more than $1,000 in college assets. Treatment participants we expect would hold their own participant-owned accounts without the intervention have $395 more in savings than their counterparts in the control group; those who are motivated by the intervention to hold a participant-owned account have mean deposits of $888. Those who are motivated by the intervention to save have mean deposits of $1,826. The intervention reduces the socioeconomic disparity in asset accumulation for children. The program has the potential to promote asset building for ...
Ultrasound‐guided subcostal transversus abdominis plane blocks with liposomal bupivacaine vs. non‐liposomal bupivacaine for postoperative pain control after laparoscopic hand‐assisted donor nephrectomy: a prospective randomised observer‐blinded study

We compared the effect of subcostal transversus abdominis plane (TAP) block with liposomal bupivacaine to TAP block with non-liposomal bupivacaine on postoperative maximal pain scores in patients undergoing donor nephrectomy. Sixty patients were prospectively randomly assigned to receive ultrasound-guided bilateral TAPs with either 1.3% liposomal bupivacaine and normal saline or 0.25% non-liposomal bupivacaine with adrenaline. There was a significant decrease in maximal pain scores in the liposomal bupivacaine TAP group when compared with the non-liposomal bupivacaine group median (IQR [range]), 24-48 h after injection, 5 (3.0-5.2 [0-10]) vs. 6 (4.5-7.0 [1--9]) p = 0.009; 48-72 h after injection, 3 (2.0-5.0 [0-8]) vs. 5 (3.0-7.0 [0-10]) p = 0.02; and in opioid use 48-72 h after injection, mean (SD) μg equivalents of fentanyl 105 (97) vs. 182 (162) p = 0.03. Liposomal bupivacaine via subcostal TAP infiltration provided superior analgesia up to 72 h after injection when compared with non-liposomal bupivacaine.
1.05 – Classification of Estuarine Circulation

In the absence of the Earth’s rotation effects, estuarine circulation represents the interaction among the contributions from gravitational circulation, tidal residual circulation, and circulation driven by tidally asymmetric vertical mixing. In turn, gravitational circulation is driven by river discharge and density gradients. Gravitational circulation tends to be dominant in many estuaries and can be classified according to the basin’s morphology or origin, to its water balance, or to the competition between tidal forcing and river discharge. Such classification as well as the circumstances under which the residual circulation induced by tidal flows and tidally asymmetric mixing are discussed in this chapter.
A high density high performance 180 nm generation Etox/sup TM/ flash memory technology

A 180 nm-generation flash memory technology has been developed, optimized for small cell size, high performance low voltage operation and multi-level-cell and embedded logic capability. Memory cell scaling utilizes scaled trench isolation, self-aligned floating gates, cobalt salicided complementary poly gates, unlanded contacts and traditional dielectric and junction scaling. Low voltage performance is achieved with the inclusion of logic compatible NMOS and PMOS transistors, a triple well and 3 layers of metal interconnect. 16 Mbit flash memories with 0.38 /spl mu/m/sup 2/ cell size have been built on this technology as a yield and reliability test vehicle.
Bilateral atypical femur fractures without bisphosphonate exposure

Atypical femur fractures have common radiographic features that set them apart from more typical higher-energy subtrochanteric femur fractures. They are noncomminuted, transverse fractures with medial spiking of the femoral cortex and increased lateral cortical thickness. These fractures have been associated in the literature with the use of bisphosphonate medications. This case describes bilateral atypical femur fractures in a patient with a medical history devoid of bisphosphonate use. We present his history, co-morbidities, and subsequent treatment. From this case, we call attention to bisphosphonate use as not the only cause of subtrochanteric femur fractures with atypical features and highlight that some patients may sustain these injuries even bilaterally without use of the medications. In addition, it is important to identify this fracture type and obtain imaging of the contralateral femur to facilitate prophylactic treatment if needed.
The Health Care Job Engine: Where Do They Come From and What Do They Say About Our Future?:

Health care has been cited as a job engine for the U.S. economy. This study used the Current Population Survey to examine the sector and occupation shifts that underlie this growth trend. Health care has had a cyclical relationship with retail trade, leisure and hospitality, education, and professional services. The entering workforce has been increasingly taking on low-skilled occupations. The exiting workforce has not been necessarily retiring or going back to school, but appeared to be leaving without a job, with potentially more child care duties, and with high rates of disability and poverty levels. This study also found that the number of workers staying in health care has been slowly declining over time. As the United States moves toward team-based care, more attention should be paid to the needs of the lower skilled workers to reduce turnover and ensure delivery of quality care.
1894 Morgan’s Canon

Do not over-credit animals with human-like capacities, look for the simplest possible explanations for animal behavior.
Children with autism spectrum disorder who improve with fever: Insights from the Simons Simplex Collection.

Literature indicates that some children with ASD may show behavioral improvements during fever; however, little is known about the behavioral profiles of these children. This study aims to (a) investigate the subset of children who show parent-reported behavioral improvements associated with fever and (b) compare the demographic, behavioral, and genetic characteristics of this subset of children to children whose parents report no change during fever. Parents of 2,152 children from the Simons Simplex Collection provided information about whether and in which areas their child improved during fever. Children were randomly assigned into discovery or replication samples. In discovery analyses, children who reportedly improved with fever (Improve Group) were compared to those who reportedly did not improve (No Improve Group) on demographics, medical history, ASD symptoms, adaptive skills, and presence of de novo ASD-associated mutations. Significant and marginal results from discovery analyses were tested in the replication sample. Parent reports of 17% of children indicated improvements during fever across a range of domains. Discovery and replication analyses revealed that the Improve Group had significantly lower non-verbal cognitive skills (NVIQ) and language levels and more repetitive behaviors. Groups did not differ on demographic variables, parent-report of current ASD symptoms or the presence of de novo mutations. Understanding the profiles of children who improve during episodes of fever may provide insights into innovative treatments for ASD. Autism Res 2018, 11: 175-184. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay summary This study explored characteristics of children with ASD who are reported to improve during fever. Parents of 17% of children with ASD report improvements across a range of domains during fever including cognition, communication, repetitive behaviors, social interaction, and behavior. Children who are reported to improve during fever have significantly lower non-verbal cognitive skills and language levels and more repetitive behaviors. Understanding the profiles of children who improve during episodes of fever may provide insights into new treatments for ASD.
Ctenophore relationships and their placement as the sister group to all other animals

Ctenophora, comprising approximately 200 described species, is an important lineage for understanding metazoan evolution and is of great ecological and economic importance. Ctenophore diversity includes species with unique colloblasts used for prey capture, smooth and striated muscles, benthic and pelagic lifestyles, and locomotion with ciliated paddles or muscular propulsion. However, the ancestral states of traits are debated and relationships among many lineages are unresolved. Here, using 27 newly sequenced ctenophore transcriptomes, publicly available data and methods to control systematic error, we establish the placement of Ctenophora as the sister group to all other animals and refine the phylogenetic relationships within ctenophores. Molecular clock analyses suggest modern ctenophore diversity originated approximately 350 million years ago ± 88 million years, conflicting with previous hypotheses, which suggest it originated approximately 65 million years ago. We recover Euplokamis dunlapae—a species with striated muscles—as the sister lineage to other sampled ctenophores. Ancestral state reconstruction shows that the most recent common ancestor of extant ctenophores was pelagic, possessed tentacles, was bioluminescent and did not have separate sexes. Our results imply at least two transitions from a pelagic to benthic lifestyle within Ctenophora, suggesting that such transitions were more common in animal diversification than previously thought. Newly sequenced transcriptomes are combined with existing data to establish Ctenophora as the sister group to all other animals and suggest a radiation around 350 Ma as well as multiple transitions from a pelagic to a benthic lifestyle.
Transcranial Doppler and Lower Extremity Function in Older Adults: Einstein Aging Study.

Objectives To determine whether transcranial Doppler ultrasound (TCD) measures of mean blood flow velocity (MBFV) in the major cerebral arteries are associated with measures of lower extremity function in community-dwelling older adults. Design Cross-sectional study. Setting Community sample. Participants Individuals aged 70 and older (mean 79.5, 54% female) without dementia participating in the Einstein Aging Study (N = 200). Measurements All participants underwent TCD assessments and tests of lower extremity function at an annual clinic visit. Average MBFV for anterior (left and right anterior and middle cerebral arteries (MCAs)) and posterior (vertebral (VA) and basilar (BA) artery) circulation was measured using a standardized TCD protocol. Lower extremity function was characterized according to gait speed (cm/s) measured using an instrumented walkway, balance according to unipedal stance time (UPST, seconds), and lower extremity strength according to timed repeated chair rise (seconds). Results Multiple regression models adjusted for age, sex, race, education, and medical comorbidities showed that lower MBFV in the MCA was associated with slower gait speed and chair rise time but not with UPST. Ordinal regression models showed that lower MBFV in the VA and BA is associated with shorter UPST. Conclusion Low MBFV in the anterior and posterior cerebral circulation was associated with worse lower extremity function and balance in older adults. This might be indicative of the importance of age-related changes in cerebral hemodynamics in the function of brain regions involved in specific aspects of physical performance.
Grinding processes for polymer matrix composites

Abstract: The chapter begins by providing some of the current applications of grinding of fiber-reinforced polymeric composites, and explains the reasons for the difficulty of using composites as machine components. The problems encountered during the grinding of composites are explained, and the different approaches for addressing these problems are discussed. The various variables affecting the operation are explained in detail. References and further sources of information and advice are also given.
Multivariate Data Glyphs: Principles and Practice

In the context of data visualization, a glyph is a visual representation of a piece of data where the attributes of a graphical entity are dictated by one or more attributes of a data record. For example, the width and height of a box could be determined by a student’s score on the midterm and final exam for a course, while the box’s color might indicate the genderof the student.Thedefinitionabove is ratherbroad, as it can cover such visual elements as the markers in a scatterplot, the bars of a histogram, or even an entire line plot. However, a narrower definition would not be sufficient to capture the wide range of data visualization techniques that have been developed over the centuries that are termed glyphs.
Reef-Associated Macroinvertebrates of the SE Gulf

In many ways the Southeastern region of the Gulf is a uniquely difficult area physiologically for macroinvertebrates to flourish in because of the extreme conditions of sea temperature and salinity that prevail in these predominantly shallow waters, particularly during the summer months. For this and other reasons linked to the Gulf’s recent geological history, the biodiversity of the macrobenthic biota in the Gulf is considered by most to be relatively low compared with that existing outside the Strait of Hormuz in the north-western Indian Ocean (Sheppard et al. 1992; Khan et al. 2002).