cssi/SciSciGPT-SciSciNet huggingface dataset:
A fast algorithm for identifying good buffer insertion candidate locations

Van Ginneken's algorithm [18] for performing buffer insertion is a classic in the field, since it optimally solves the problem subject to a set of fixed buffer insertion candidate locations for a given Steiner topology. The generation of these candidate locations is typically performed by dividing the routed wires into small uniformly sized pieces [1]. However, certain regions of the layout are generally more attractive to place buffers than others, e.g., sparse regions are preferred to dense ones. This work presents a fast, shortest path based algorithm to identify good candidate buffer insertion locations to be passed to van Ginneken's algorithm. Our experiments show that the buffers inserted significantly improve the overall design density with virtually no impact on either CPU time or buffered net delays.
Research on the Peripheral Sound Visualization Using the Improved Ripple Mode

In this paper, we proposed a peripheral sound visualization method based on improved ripple mode for the deaf. In proposed mode, we designed the processes of transforming sound intensity and exterminating the locations of sound sources. We used power spectrum function to determine the sound intensity. ARTI neural network was subtly applied to identify which kind of the real-time input sound signals and to display the locations of the sound sources. We present the software that aids the development of peripheral displays and four sample peripheral displays are used to demonstrate our toolkit’s capabilities. The results show that the proposed ripple mode correctly showed the information of combination of the sound intensity and location of the sound source and ART1 neural network made accurate identifications for input audio signals. Moreover, we found that participants in the research were more likely to achieve more information of locations of sound sources.
Partial parallel interference cancellation for CDMA systems employing antenna arrays

A new method for partial interference cancellation in base station receivers that are equipped with antenna arrays is developed for code division multiple access systems. We show that the partial cancellation method has better performance if we cancel the interference caused by other users according to their detected information reliability using different weight coefficients. The values of partial weight coefficients are obtained by solving an optimization problem that attempts to remove other users' contributions from the signal going to the next stage for the desired user. It is shown that the present space-time multiuser detection technique outperforms the complete parallel interference cancellation method where the increase in the receiver complexity is negligible.
The orange carotenoid protein of Synechocystis PCC 6803

Abstract A water soluble protein with the carotenoid 3′-hydroxyequinenone bound to it has been purified from the cyanobacterium Synechocystis PCC 6803. Based on partial amino acid sequencing of the protein, oligonucleotides were synthesized and used as primers for PCR to obtain a substantial fragment of the gene. This DNA was sequenced and the sequence data and the size of the protein indicate that the protein is encoded by gene slr 1963 in the Kazusa DNA sequence data bank containing the Synechocystis 6803 genome. This protein is very similar to 3′-hydroxyechinenone proteins found in several other cyanobacteria but it shows very little resemblance in its amino acid or gene sequence to other carotenoid binding proteins. The protein binds 1–2 molecules of 3′-hydroxyechinenone and is slowly cleaved by proteases in the cell extract to give a molecule of approximately half the original mass which retains the carotenoid and which shows a striking change in color.
High Electric Fields in II-VI Materials.

Conventional electrophotographic processes operate with blocking contacts. This limits the available gain at low fields: one electron discharged per absorbed photon, at the most, during the photoconductive step of the process. A straightforward way to increase the gain is to increase the applied field until carriers multiply by impact ionization during their transit through the material. This requires high electric fields of order 106 V/cm, and in such high fields there is inevitably an increase in the dark current. In this competition between dark current and multiplication the irreducible source of increased dark current is Zener tunneling of carriers from valence band to conduction band. Examination of the form of current-voltage relations for tunneling and impact ionization shows that specimen dimensions have an important effect in shifting the balance in favor of multiplication. The multiplication properties have recently been studied for three II–VI materials with high band-gaps: ZnSe, CdS, and ZnO. High fields are produced with electrolyte blocking contacts to n type conducting crystals. Multiplication is seen in fields around 106 V/cm in ZnSe and ZnO, but not in CdS where the ultimate breakdown is by tunneling. Since the band gaps and low field mobilities are almost the same for ZnSe and CdS, this difference indicates that rather subtle features can be decisive in determining whether or not impact ionization takes place. Measurements have been made of charging and discharging of the free surface on ZnO single crystals. High fields can be achieved under these conditions, and there is tentative evidence that electron multiplication can contribute to the discharge.
Blame Attributions of Victims and Perpetrators Effects of Victim Gender, Perpetrator Gender, and Relationship

Although research has been conducted on rape myth acceptance (RMA) and other factors associated with attribution formation, researchers have not yet determined how the combination of such factors simultaneously affects levels of victim blame and perpetrator blame. The current investigation recruited 221 students from an all-women’s college to examine differences in blame attributions across RMA, victim gender, and perpetrator gender, and the relationship between the two parties (i.e., stranger vs. acquaintance). Results suggested that RMA, victim gender, and perpetrator gender account for a significant amount of variance in blame attributions for both victims and perpetrators. In sum, victim blame with female perpetrators was relatively consistent across levels of RMA, but increased substantially for male perpetrators as individuals endorsed higher levels of RMA. Perpetrator blame, however, was highest with male perpetrators when individuals endorsed low levels of RMA and lowest for male perpetrators when...
Cerebellar role in Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disorder associated with motor and cognitive impairments. The mechanisms underlying the pathophysiology and treatments have traditionally focused on basal ganglia-thalamo-cortical pathways due to striatal dopamine loss, but more recent evidence has highlighted the role of the cerebellum. In this Neuro Forum article, I review evidence from neuroimaging and noninvasive brain stimulation that demonstrates altered cerebellar activity in PD may be both a pathophysiological and compensatory mechanism depending on dopaminergic medication and symptoms.
Structured languages

A design process is a highly creative undertaking that has been generally guided by personal experiences and gross rules of design. This fact has been made explicit and at present the essence of the process of design is under investigation. This important problem is receiving attention in Computer Science. In particular, disciplined program design and development is the center of much discussion.
The Role of Photography in the Protection, Identification, and Recovery of Cultural Heritage

This article seeks to contribute to the study surrounding documentation and the illicit trade in cultural property by examining the uses of photography by the international community. Popular and academic literature, news reports, and online databases reveal three primary and interconnected relationships that exist between photography and the trade of cultural heritage. This article presents photography as, first, an aid for the protection and identification of cultural heritage and, second, as a form of evidence to support an ownership claim by a country calling for repatriation.
Laparoscopic cannulation of an accessory hepatic duct: a case report.

ABSTRACT Anomalies of the cystic duct are commonly encountered by the operating surgeon. Accessory hepatic ducts directly entering the gallbladder are among the most difficult of these to identify. Because of magnification, laparoscopy provides oftentimes superior visualization of the biliary tree. Herein, we describe a case in which an accessory hepatic duct was identified, cannulated, and evaluated with cholangiography enabling appropriate operative treatment.
Emerging perspectives on transforming the healthcare system: key conceptual issues.

BackgroundDespite reform efforts, today's healthcare system faces multiple challenges. Limitations of the current system result in major gaps between evidence and practice, suboptimal quality, inequitable patterns of utilization, inadequate safety and reliability, and unsustainable cost increases. F
Novel cancer stem cell therapy on the horizon.

Commentary to:7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: A novel compound capable of inducing cell death in epithelial ovarian cancer stem cellsJamie M. Green, Ayesha B. Alvero, Fortune Kohen, Gil Mor
Analysis of K-ras, N-ras, H-ras, and p53 in Lung Neuroendocrine Neoplasms

This study screened 11 samples of typical carcinoid (TC), 4 samples of atypical carcinoid (AC), 1 sample of large cell neuroendocrine carcinoma (LCNEC), and four metastases for point mutations in exons 5 to 8 of the p53 gene, and exons 1 and 2 of the K-ras. H-ras, and N-ras genes using polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) and direct sequencing and by immunohistochemistry for p53. Exon 1 of K-ras was mutated in two samples of low-grade AC and a metastasis from one of these tumors (GAT12 and AGT12, respectively). No mutations in N-ras or H-ras were found. Mutations in exons 5 and 8 of the p53 gene were identified in a high-grade AC and a LCNEC. Positive immunostaining for p53 was present in three samples, with only one genotypic mutation shown (LCNEC). In conclusion, point mutations of the p53 gene were infrequent in these pulmonary neuroendocrine tumors, did not correlate in all samples with immunostaining, and were associated with the higher-grade tumors. Second, the presence of K-ras mutations seems to be associated with the higher-grade carcinomas. Third, N-ras and H-ras mutations were not found with these pulmonary neuroendocrine tumors.
Lasing without inversion experiments and theory

Quantum coherence and correlations in atomic systems have many interesting and potentially useful consequences, such as cancellation of absorption, lasing without inversion, and enhancement of the index of refraction without absorption.
Physical vapor deposited AlN as scalable and reliable interconnect etch-stop ≤ 10nm node

Physical vapor deposited (PVD) AlN is introduced as a novel interconnect etch-stop layer. Superior dielectric etch selectivity is demonstrated over conventional silicon-based etch-stops, due to minimized impurity and high film density provided by PVD. This enables reduction of etch stop thickness, resulting in 5% capacitance reduction at 10nm node dimensions. Interface control and film treatments are optimized to improve reliability. PVD AlN is compatible with selective Co capping layer for electro-migration improvements. Control of film doping extends the film beyond 10nm technology node.
Abstract 178: Effects of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline in Experimental Autoimmune Mocarditis

Background: Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP), a naturally occurring tetrapeptide, prevents autoimmune cardiac dysfunction and remodeling. The mechanism by which this occurs remains unknown. Experimental autoimmune myocarditis (EAM), a T cell-mediated autoimmune disease, is a model of autoimmune cardiac injury. Cytokines and adhesion molecules are necessary for the development of EAM. We hypothesized that Ac-SDKP prevents autoimmune cardiac injury by reducing T cell response, pro-inflammatory cytokines and adhesion molecules. Methods and results: EAM was induced by immunization of rats with porcine cardiac myosin, followed by s.c. infusion of vehicle or Ac-SDKP (800 μg.kg-1.d-1) via osmotic minipumps. By 3 weeks post-immunization, we evaluated cell-mediated immunity by delayed-type hypersensitivity, myocardial T helper infiltration by immunohistochemistry and both cytokines and adhesion molecules were measured with a proteomic array kit. Ac-SDKP prevented increases in 1) Delayed-type sensitivity (EAM, 0.35±0.06 vs EAM + Ac-SDKP, 0.16±0.01** mm), 2) infiltration by T helper cells (148±20 vs 97±17*** CD4 cells/mm2), 3) pro-inflammatory cytokines [Tumor necrosis factor-α (0.98±0.20 vs 0.17±0.03** A.U.); Interleukin (IL)-1β (13.7±2.9 vs 0.29±0.07*** A.U.); IP-10, a T helper type 1 chemokine (1.54±0.23 vs 0.30±0.08*); IL-17, a T helper type 17 cytokine (1.9±0.3 vs 0.8±0.3* A.U.)] and 4) Cell adhesion molecules [L-selectin (42.4±4.8 vs 9.1±1.9***) and Intercellular adhesion molecule 1 (54.1±3.1 vs 19.1±2.8***)]. Conclusion: Prevention of autoimmune cardiac injury by Ac-SDKP is correlated by decreased cell-mediated immunity. The protective effects of Ac-SDKP are likely mediated by reduction of T cell infiltration, pro-inflammatory cytokines and cell adhesion molecules. *p
Profit Sharing: A Contracting Solution to Harness the Wisdom of the Crowd

When a group of investors with dispersed private information jointly invest in a risky project, how should they divide the project payoff? The typical approach with common stocks rewards investors in proportion to their initial investment, but is it really optimal? Answers to these questions have implications for many business activities in our information age, including the efficacy of the emerging practice of security-based crowdfunding in harnessing the "wisdom of the crowd." This paper shows that simple profit-sharing contracts with decentralized decision making could first best coordinate individuals' investment choices, and hence optimally utilize the group's collective wisdom. This result connects the traditional diversification insight underpinning portfolio theory to investment under private information.
Cabozantinib (C), erlotinib (E) or the combination (E+C) as second- or third-line therapy in patients with EGFR wild-type (wt) non-small cell lung cancer (NSCLC): A randomized phase 2 trial of the ECOG-ACRIN Cancer Research Group (E1512).

8003 Background: Cabozantinib (C) is a small molecule inhibitor of multiple receptor tyrosine kinases, including MET, VEGFR2 & RET. MET is involved in tumor differentiation & VEGFR2 is a mediator of angiogenesis. Erlotinib (E) is FDA approved for the treatment of NSCLC. Methods: The primary objective of this randomized phase II study was to compare progression-free survival (PFS) of patients (pts) treated with E vs. C, & E vs E+C; each comparison had 91% power to detect a PFS hazard ratio (HR) of 0.5 with a 1-sided 0.10-level test stratified on prior number of therapies & ECOG PS. Secondary objectives included overall survival (OS), RECIST 1.1 response & CTCAE v4 toxicity. Pts were selected with previously treated (1-2 regimens) metastatic non-squamous EGFR wt NSCLC. Submission of archival tissue for central MET IHC testing was required. Oral daily dosing was: E-150 mg; C-60 mg; E+C-150 mg E, 40 mg C. Imaging was performed every 8 weeks. Pts optionally crossed over to E+C following progression on E or C. ...
IC-processed electrostatic micro-motors

The authors describe the design, fabrication, and operation of several micromotors that have been produced using integrated-circuit processing. Both rotors and stators for these motors, which are driven by electrostatic forces, are formed from 1.0-1.5- mu m-thick polycrystalline silicon. The diameters of the rotors in the motors tested are between 60 and 120 mu m. Motors with several friction-reducing designs have been fabricated using phosphosilicate glass (PSG) as a sacrificial material and either one or three polysilicon depositions. Examples of stepping and three-phase synchronous drive micromotors are described. Typical drive voltages for present designs exceed 100 V. Manually switched motors have tested at speeds up to 12 r.p.m. Synchronous motors have been driven at speeds to 500 r.p.m. >
Civil versus Military Administration: The Interior Department's Position on U.S. Pacific Territories, 1945-1947

Between 1945 and 1947, the United States set out to, and largely succeeded in, creating an exclusive strategic sphere in the Pacific Basin. Concerned about a potentially resurgent Japan and an increasingly threatening Soviet Union, the United States was determined to turn the Pacific Ocean into an "American lake." The United States, however, had to ensure these measures did not appear to be imperialistic. Accordingly, the War, Navy, State, and Interior Departments debated with each other about how to create the American lake effect without the United States being branded a colonial power. The Interior Department thought that it had the answer. Because of its history of territorial administration, Interior was convinced that it was best suited to Pacific Island civil administration. Its ideas would lead to Pacific Islands that became more thoroughly colonized and Americanized by the 1990s than anyone in the 1940s probably ever hoped was possible.
Electronic Alerts Improve Immunization Rates in Two-month-old Premature Infants Hospitalized in the Neonatal Intensive Care Unit

Objective: To determine if an electronic alert improves 2 month immunization rates in infants remaining hospitalized in the neonatal intensive care unit. Methods: Institutional Review Board-approved retrospective chart review of 261 infants with birth weights <2 kg and still hospitalized at ≥ 58 days. Charts were reviewed between 2009 and 2013, before and after the 2011 electronic alert was instituted in the electronic medical record from days 56 to 67 to remind providers that immunizations were due. Order and administration dates of two-month vaccine components (Diphtheria, Haemophilus influenza B, Hepatitis B, Pertussis, Pneumococcal, Polio, Tetanus) were determined, and infants were considered fully immunized, partially immunized, or unimmunized by day 90 or discharge, whichever came first. Results: After the alert, the timing of vaccine orders decreased from day 67 to day 61 (p<0.0001) and vaccine administration decreased from day 71 to day 64 (p<0.0001). Missing vaccine orders decreased from 14% [17/121] to 3% [4/140] (p=0.001) with missing administrations decreasing from 21% [26/121] to 4% [6/140] (p<0.0001). Fully immunized rates increased from 71% [86/121] to 94% [132/140] (p<0.0001). Conclusions: A significant improvement in immunization rates in two-month-old infants in the neonatal intensive care unit occurred by 90 days after implementing an alert in the electronic medical record.
The Evolution of Human Co-operation: Ritual and Social Complexity in Stateless Societies

How do people living in small groups without money, markets, police and rigid social classes develop norms of economic and social cooperation that are sustainable over time? This book addresses this fundamental question and explains the origin, structure and spread of stateless societies. Using insights from game theory, ethnography and archaeology, Stanish shows how ritual - broadly defined - is the key. Ritual practices encode elaborate rules of behavior and are ingenious mechanisms of organizing society in the absence of coercive states. As well as asking why and how people choose to co-operate, Stanish also provides the theoretical framework to understand this collective action problem. He goes on to highlight the evolution of cooperation with ethnographic and archaeological data from around of the world. Merging evolutionary game theory concepts with cultural evolutionary theory, this book will appeal to those seeking a transdisciplinary approach to one of the greatest problems in human evolution.
East Meets West: The Cultural History of Television in Bulgaria

This study provides a glimpse into the cultural history of the popular medium of television for the period 1944-2016. Seeking a more nuanced and more evolved understanding of the role of the television in Bulgaria during socialist and in post-socialist times, this essay argues for a ‘situated’ reading of these historical developments, theorising that socialist and post-socialist television are indeed defined by disparate, yet equally influential and dynamic, cultural and political processes. From the ‘golden age’ of communist-era television, during which TV was hailed as a main force for mobilisation, education and entertainment, we will trace the ‘boom’ in commercial TV channels at the offset of the transition, with its often-questionable quality, leading to the emergence of several serious contenders on the broadcasting scene, both in terms of their financial value and in terms of their power over public opinion.
Phase-resolved spectroscopy of the low-mass X-ray binary V801 Ara

We present phase-resolved optical spectra of the low mass X-ray binary system V801 Ara. The spectra, obtained in 2014 with IMACS on the Magellan/Baade telescope at Las Campanas Observatory, cover the full binary orbit of 3.8 hours. They contain strong emission features allowing us to map the emission of HAlpha, HBeta, He II 4686, and the Bowen blend at 4640. The radial velocity curves of the Bowen blend shows significantly stronger modulation at the orbital period than HAlpha as expected for the former originating on the secondary with the latter consistent with emission dominated by the disk. Our tomograms of HAlpha and HBeta are the most detailed studies of these lines for V801 to date and they clearly detect the accretion disk. The HBeta emission extends to higher velocities than HAlpha, suggesting emission from closer to the neutron star and differentiating temperature variance in the accretion disk for the first time. The center of the accretion disk appears offset from the center-of-mass of the neutron star as has been seen in several other X-ray binaries. This is often interpreted to imply disk eccentricity. Our tomograms do not show strong evidence for a hot spot at the point where the accretion stream hits the disk. This could imply a reduced accretion rate or could be due to the spot being drowned out by bright accretion flow around it. There is enhanced emission further along the disk, however, which implies gas stream interaction downstream of the hot spot.
The Age of Trolleys

Trolleys were the bridging technology between the horse-drawn streetcar and the motor bus. The former operated into the 1890s in abundance, with one straggler lasting as long as 1917. The latter became a major part of the public transportation system through the 1930s and 1940s.
An Empirical Examination of Effective Practices for Teaching Board Game Play to Young Children.

We examined an intervention package using peer modeling, systematic prompting, and contingent reinforcement to increase the frequency and complexity of board game play and social behaviors in young children with disabilities. Four children with or at risk for disabilities participated with their typically developing peers. Results indicated a strong functional relation given the magnitude of change across conditions and participants and robust study rigor. Minor individual adaptations were used for two of the four participants. Overall, the study extends the research on board game play interventions with young children by demonstrating the effectiveness of an intervention that was successful for a diverse sample of preschool children with or at risk for disabilities and their peers.
Primary hepatic peripheral T-cell lymphoma associated with Epstein-Barr viral infection

Primary hepatic peripheral T-cell lymphoma (H-PTCL) is one of the rarest forms of non-Hodgkin lymphoma. We report a patient who presented with worsening jaundice, abdominal pain, and vomiting. Laboratory values were significant for elevated total bilirubin, alkaline phosphatase, and liver aminotransferases. Following a liver biopsy, histopathology revealed several large dense clusters of atypical T-lymphocytes which were CD2+, CD3+, CD5+, CD7-, CD4+, CD8-, CD56-, CD57-, CD30+ by immunohistochemistry. The proliferation index was approximately 70% by labeling for ki67/mib1. The above histological profile was consistent with peripheral T-cell lymphoma of the liver. Epstein-Barr viral serology indicated a remote infection, a likely risk factor for PTCL. Bone marrow biopsy was negative for malignancy, further supporting hepatic origin.
Impact of Chronic Obstructive Pulmonary Disease on Postoperative Complication Rates, Ambulation, and Length of Hospital Stay After Elective Spinal Fusion (≥3 Levels) in Elderly Spine Deformity Patients.

Objective To investigate the impact that chronic obstructive pulmonary disease (COPD) has on postoperative complication rates, ambulation, and hospital length of stay for elderly spinal deformity patients after elective spinal fusion (≥3 levels). Methods The medical records of 559 elderly (≥60 years old) spine deformity patients undergoing elective spinal fusion (≥3 levels) at a major academic institution from 2005 to 2015 were reviewed. We identified 60 patients with COPD (10.7%) and 499 patients without COPD (89.3%). Patient demographics, comorbidities, postoperative complications, ambulatory status, and readmission rates were collected. The primary outcomes investigated in this study were complication rates and length of hospital stay. Results Demographics and comorbidities were similar between groups, with a difference in proportion of smokers (COPD group: 25.0% vs. no COPD group: 9.6%, P = 0.0004). The median number of fusion levels (P = 0.840), operative time (P = 0.842), estimated blood loss (P = 0.336), and incidences of durotomy (P = 0.258) was similar between both cohorts. The COPD cohort experienced a higher rate of postoperative fever (10.0% vs. 3.0%, P = 0.007) and pneumonia (5.0% vs. 0.4%, P = 0.0004), respectively. There was a significant difference in the number of feet walked on the first day of ambulation after surgery (COPD group: 58.6 ± 78.4 vs. no COPD group: 84.0 ± 102.8, P = 0.040). Length of hospital stay was significantly longer in the COPD cohort than the no COPD cohort (7.7 ± 6.4 vs. 6.0 ± 4.0 days, respectively; P = 0.0498). Conclusions Our study demonstrates that elderly patients with COPD have increased lengths of stay and higher rates of postoperative pneumonia after spinal fusion. This determination identifies a potentially modifiable risk factor for increased utilization of health care resources.
Integrating Concurrent Engineering and CIM into a Manufacturing Engineering Technology Program

Publisher Summary Concurrent engineering or simultaneous engineering, computer integrated manufacturing (CIM) and design for manufacturability (DFM) principles have been integrated into the philosophical approach of major manufacturing firms in the United States. CIM continues to play a key role in modern manufacturing methods. This chapter focuses on the accomplishments to incorporate concurrent engineering, CIM and DFM into the program and on the changes that are currently being made into the program to guarantee the total integration challenge. Solids modeling and rendering has become very popular in industry both in industrial design and engineering because it enhances visualization of the problem at hand. Engineering technologists are often called upon in industry to solve practical problems in manufacturing processes, plan production processes, design manufacturing tooling and fixturing, specify and develop quality assurance plans, develop materials handling and processing procedures, develop and implement automation processes, plan manufacturing procedures, and design test sequences.
INFLUENZA IMMUNOPROPHYLAXIS AFTER 30 YEARS' EXPERIENCE

The summary report of the Secretary's Conference on Influenza, held July 26, 1978, states that “As a broad generalization, influenza vaccine can be expected to prevent infection and disease for 1-2 years after vaccination in about 7 of 10 people who receive it.” The key word is “generalization.” After 30 years, questions still persist about the efficacy of inactivated vaccines under certain conditions and in certain populations for whom the vaccine is recommended, particularly the elderly. Many questions related to efficacy stem from the inate antigenic and biologic variability of influenza viruses and the variable susceptibility of host populations. Other questions relate to the validity of the vaccine trial itself and the methods used to evaluate efficacy. In vaccine formulation emphasis has been placed on minimal dosages because of cost and undesirable toxic reactions. Newly emerging technology makes it possible to consider vaccines of significantly greater concentrations which may provide answers to many of the questions on vaccine efficacy.
Conclusion: From Social Indexes to Imagined Ones

To apprehend mental Indexes several revolutions of indexical sign use must have been attained.
Proceedings of the 3rd ACM workshop on Cloud computing security workshop

Cloud computing has clearly established itself as a crucial element in the information-technology landscape of today. This means that people are affected not only by the features and benefits of this new computing model, but also by any problems. Concerns about cloud computing security exist due to its new untested deployment models, novel trust and adversarial relations, and new vulnerabilities. The Cloud Computing Security Workshop (CCSW) aims to bring together researchers and practitioners working in all security aspects of cloud-centric and outsourced computing. Now in its 3rd instance, and co-located with the 18th ACM Conference on Computer and Communications Security (CCS), CCSW has established itself as the premier scientific forum for research in cloud computing security. In response to the call for papers, the international program committee received 45 contributions of high quality. Given the constraints of a one-day workshop, the program committee decided to accept 13 contributions, among them eight long research papers, three short research papers, and two position papers. The program of the workshop was complemented by three keynote lectures from renowned security experts: Tim Brown, SVP Chief Security Architect & Distinguished Engineer (CA Technologies, Security Business); Charlie Kaufman, Security Architect, Windows Azure (Microsoft); and John Manferdelli, Senior Principal Engineer and co-lead of the Intel Science and Technology Center for Secure Computing (Intel).
Shoulder Joint Pain

Owing to an extensive range of motion, the stability of the shoulder joint depends heavily on important ligament and muscular attachments. Overuse or acute injuries to any of these structures predisposes to the pathologic conditions of shoulder pain and instability. Isolation of anatomic structures through physical exam is crucial to develop a differential diagnosis and treatment plan.
Electronic Records Management in Romania: More Electronic-, Less Records-Management

The management of electronic records and documents seems to be very developed in Romania. Mostly under UE financing, a lot of institutions implemented modern systems and digitized legacy paper records. Pertinent pieces of legislation were adopted (time-stamp, electronic signature and even an electronic archiving act) and this might create an image of proper regulated environment. But a closer look to the facts shows that proper electronic records management lacks almost completely. The paper will look into details about the way modern archives are prepared for the future.
Exploration of a Marital Typology: Implications for Marital Functioning in a Multi-Ethnic Sample.

Marital conflict is associated with multiple negative outcomes for couples, including marital dissatisfaction and divorce. Little research, however, has examined conflict in Hispanic/Latino couples or its association with marital satisfaction, which creates an unfortunate knowledge gap for clinicians working with diverse client groups. The present study sought to examine both marital conflict and satisfaction using a sample of 231 European American (EA; n = 108) and Hispanic/Latino (H/L; n = 123) couples. Through observational coding, couples were placed into four groups based on their type of conflict management strategies: Harmonious, Withdrawn, Conflictual-Expressive, or Conflictual-Hostile. For both ethnic groups, couples in the Harmonious group were nondistressed and couples in the Conflictual-Hostile group were in the distressed range of marital satisfaction. Cross-ethnic differences emerged. EA couples experienced distress when both hostile (Conflictual-Hostile) and nonhostile conflict (Conflictual-Expressive) communication types were observed, while only hostile conflict was associated with distress for the H/L group. H/L couples reported similar levels of satisfaction in both the Harmonious and Conflictual-Expressive groups. H/L couples also fell within the distressed range when withdrawn communication patterns were observed; however, this was not the case for EA couples. These differences suggest that both types of conflict are associated with marital distress for EA couples, whereas hostile conflict and withdrawn behavior appear to be more negatively associated with marital satisfaction in H/L couples. Results provide support for the use of an observational coding system with H/L and EA couples and also suggest the importance of understanding how differences in expressions of conflict across ethnicities may relate to marital satisfaction.
EduGit: Toward a Platform for Publishing and Adopting Course Content

In light of the continued dearth of an online Community of Practice for the collaborative development and distribution of educational materials for Human Computer Interaction, we propose EduGit. EduGit is a web application that serves as a platform for publishing, adopting, and collaboratively authoring educational resources. The system facilitates and incentivizes publishing and adoption of course materials through interactions with existing learning management systems and estimates impact through aggregate material adoption and usage statistics.
Surveillance on the incidence of acute coronary events in the permanent residents aged 25 years and more from 2010 to 2012 in Zhejiang province

Objective To survey the incidence of acute coronary events(nonfatal acute myocardial infarction and death from coronary heart disease), and analyze the trend and distribution characteristics in permanent residents aged 25 years and more across 30 surveillance regions of Zhejiang province from 2010 to 2012. Methods Through databases matching and duplicate checking, this study incorporated the register module of coronary disease and the cause of death register module in Zhejiang provincial information system for chronic non-communicable diseases surveillance and management. The distribution of incidence was calculated across gender, age groups, regions and times. Results A total of 31 872 person-time acute coronary events were identified. The gender- and age-standardized mean annual incidence was 81.56 per 100 000 people in overall population, with 94.33 in males and 68.27 in females. Age-standardized incidence was 87.90 and 77.36 per 100 000 people in urban and rural area, respectively. Urban area had higher incidence rate than rural in each of the three years, and had obvious trend of increasing (P<0.001) compared with rural area (P=0.331). Incidence rate also increased significantly with age (P<0.001). In addition, compared with women, men had higher incidence in each age group (all P<0.001). The incidence rate increased rapidly in population older than 75 years old. The highest incidence was observed in age group ≥85 years old, with 2 371.67 and 1 873.92 per 100 000 in males and females, respectively. Apparent seasonal trend was observed for acute coronary events, which was low in summer and high in winter. Conclusions Quantity and incidence for acute coronary events in residents aged 25 years and more of Zhejiang surveillance regions increased during 2010 to 2012. Male had higher incidence than female, and the incidence in urban areas was higher compared with rural areas. Residents older than 75 years old were high risk population of events, and winter was the high-occurrence season. Key words: Coronary disease; Incidence; Epidemiologic studies
Polarization-Independent Perfect Optical Metamaterial Absorber as a Glucose Sensor in Food Industry Applications

Perfect optical metamaterial absorbers (POMMA) utilize intrinsic loss, with the aid of appropriate structural design, to achieve near unity absorption at a certain wavelength. In all the reported absorbers, the absorption occurs only at a single wavelength or dual/multi-band wavelengths where plasmon resonances are ex-cited in the nanostructure. Here we not only show a single-band perfect absorber but also demonstrate that our proposed design has the ability to be multi-band absorber at the same structure. Furthermore, we numerically demonstrate the proposed POMMA can be utilized as a glucose sensor for refractive index sensing which has more than 225 nm/RIU sensitivity at the infrared frequency regime which is good value. Its polarization-independent absorbance is about 100% at normal incidence for both TE and TM polarization modes. The proposed optical glucose sensor offers great potential to maintain the performance of localized surface plasmon (LSP) sensors in nanostructures in food industry applications.
Early breast development in overweight girls: does estrogen made by adipose tissue play a role?

Girls who are overweight/obese (OB) develop breast tissue but do not undergo menarche (the first menstrual period) significantly earlier than girls of normal weight (NW). It has been proposed that estrogen synthesized by adipose tissue may be contributory, yet OB do not have higher serum estrogen levels than NW matched on breast stage. We hypothesized that estrogen synthesized locally, in mammary fat, may contribute to breast development. This hypothesis would predict that breast development would be more advanced than other estrogen-sensitive tissues as a function of obesity and body fat. Eighty premenarchal girls (26 OB, 54 NW), aged 8.2–14.7 years, underwent dual-energy x-ray absorptiometry to calculate percent body fat (%BF), Tanner staging of the breast, breast ultrasound for morphological staging, trans-abdominal pelvic ultrasound, hand x-ray (bone age, BA), a blood test for reproductive hormones, and urine collection to determine the vaginal maturation index (VMI), an index of estrogen exposure in urogenital epithelial cells. When controlling for breast morphological stage determined by ultrasound, %BF was not associated with serum estrogen or gonadotropin (LH and FSH) levels or with indices of systemic estrogen action (uterine volume, endometrial thickness, BA advancement, and VMI). Tanner breast stage did not correlate with breast morphological stage and led to misclassification of chest fatty tissue as breast tissue in some OB. These studies do not support the hypothesis that estrogen derived from total body fat or local (mammary) fat contributes to breast development in OB girls.
Hidden Realities and the Language of the Prophets of Science

The cosmological narrative, based on scientific theories, reaches deep into the fabric of the modern world. From university lecture halls to movie theatres, from astronomical observatories on isolated mountain tops to public talks, “Prophets of Science” captivate the imagination of millions. The following essay is aimed at describing the social dimension, distribution and consequences of scientific knowledge. To accomplish this goal, I will compare the mythological lore present in the Amazon Basin and the scientific worldview of the industrialized West. Such juxtaposition is focused on western science, where references to another knowledge system are used to enrich the overall argument and as a catalyst of effective self-reflection on modern society. In the course of the essay, I intend to communicate the heterogeneity of both Amazonian and Western societies. The specific examples will be aimed at underscoring the contexts and mechanisms of knowledge distribution, rather than the content. In the first part, I will discuss the role of metaphor in scientific discourse. Subsequently, I will describe variations in lay and expert interpretations of knowledge. The essay will be concluded with an overview of the literature interpreting science as mythology.
Abstract A51: Advances in the etiology and therapeutics of a lethal childhood cancer, fibrolamellar hepatocellular carcinoma

Introduction: Fibrolamellar hepatocellular carcinoma (FLC) is a liver cancer affecting adolescents and young adults without underlying liver disease. Patients with FLC are often diagnosed with advanced-stage disease and have a poor 5-year survival. Recently we have made advances in both understanding the etiology of FLC as well as developing therapeutics. We have found that the bulk of the genome lacks recurrent single-nucleotide or structural variants (inversions, amplifications) with the exception of a deletion in one copy of chromosome 19. This results in a fusion of the first exon of the heat shock protein, DNAJB1, with the 2nd through 10th exons of PRKACA, the catalytic subunit of protein kinase A. Expression of this fusion in the livers of mice, either by CRISPR or transposon, is sufficient to phenocopy the disease. The kinase activity of the fusion protein is essential for transformation, but equivalent expression of the native kinase is not sufficient. Results: Etiology: We have tested the ability of the native kinase and fusion oncokinase to phosphorylate potential substrates in human liver. We have found a discrete set of substrates that are phosphorylated in human liver for which we are now testing, which are critical for the pathogenesis of this cancer. Therapeutics: We have purified the fusion oncokinase without a tag and used a high-throughput screen to find inhibitors. We have found inhibitors in the nanomolar range for which we are using structural analysis to inform our medicinal chemistry. Additionally, we have developed several “never-in-plastic” patient-derived xenograft (PDX) models that retain expression of the driver, histology, transcriptome, and proteome of the original human tumor. We have also screened for compounds that induce tumor cell death and tumor regression in FLC PDXs. Conclusion: Subtle changes in the kinase substrate profile of the fusion kinase provide new leads for therapeutics for FLC. The ability to find inhibitors of the kinase in the nanomolar range, as well as the ability to screen for inhibitors of the PDX, offers the first hope for treatment against this lethal tumor. Citation Format: Gadi Lalazar, Melissa Jarmel, Ruisi Wang, Michael Tomasini, David Requena, Denise Ng, Sanford M. Simon. Advances in the etiology and therapeutics of a lethal childhood cancer, fibrolamellar hepatocellular carcinoma [abstract]. In: Proceedings of the AACR Special Conference on the Advances in Pediatric Cancer Research; 2019 Sep 17-20; Montreal, QC, Canada. Philadelphia (PA): AACR; Cancer Res 2020;80(14 Suppl):Abstract nr A51.
Integrated omics networks reveal the temporal signaling events of brassinosteroid response in Arabidopsis

Brassinosteroids (BRs) are plant steroid hormones that are known to regulate cell division and stress response. We used a systems biology approach to integrate multi-omic datasets and unravel the molecular signaling events of BR response in Arabidopsis. We profiled the levels of 32,549 transcripts, 9,035 protein groups, and 26,950 phosphorylation sites from Arabidopsis seedlings treated with brassinolide (BL, most active BR) for six different lengths of time. We then constructed a network inference pipeline called Spatiotemporal Clustering and Inference of Omics Networks (SC-ION) that was able to integrate these multi-omic data into one, cohesive regulatory network. Our network illustrates the signaling cascade of BR response, starting with kinase-substrate phosphorylation and ending with transcriptional regulation. We used our network predictions to identify putative, relevant phosphorylation sites on the TF BRI1-EMS-SUPPRESSOR 1 (BES1); the importance of which we experimentally validated. Additionally, we identified an uncharacterized TF, which we named BRONTOSAURUS (BRON), that regulates cell division. Further, we show that bron mutant roots are hypersensitive to BL. Together, this work demonstrates the power of integrative network analysis applied to multiomic data and provides fundamental insights into the molecular signaling events occurring during BR response.
Scalable Production of Graphene Nanoplatelets for Energy Storage

The difficulty of scaling up the production of high-quality graphene nanoplatelets remains a major challenge for the graphene community and inhibits commercialization across a variety of market seg...
Dependence of Nonlinear Response and Magnon Scattering on Damping

A previous theoretical model of 3-magnon scattering is connected to experimentally measured characteristics, such as the damping constant α and the power threshold, through a realistic micromagnetic simulation. Both the critical magnon amplitude and relaxation rate are determined to be proportional to α which implies that the power threshold scales sensitively as α4. In addition, the scattered magnons are found to form two sets of symmetric wavevector k ≠ 0 magnon pairs, which are focused over a small range of angles and robust for a wide power range. Our results increase understanding of the model with respect to experimental and engineering aspects, and reduce the trial and error approach to application design.