cssi/SciSciGPT-SciSciNet huggingface dataset:
Duplications in Caenorhabditis elegans.

ABSTRACT Thirteen chromosomal duplications, all unlinked to their linkage group of origin, have been identified following X-irradiation. Ten are X -chromosome duplications, of which six are half-translocations on three autosomomal linkage groups and four are free fragments. Five of the half-translocations are homozygous fertile and two are recognizable cytologically as chromosome satellites, both of which show some mitotic instability. The free- X duplications show varying tendencies for loss. Three appear not to overlap in extent previously identified free- X duplications. The fourth carries genes from linkage group V , as well as X . Three duplications of a portion of linkage group II were identified and found to be free and quite stable in hyperploids. Some of the free duplications tend to disjoin from the X chromosome in males. New X -chromosome map data are presented.
The Roles of Sex, Empathy, and Credibility in Out-of-Class Communication Between Faculty and Students

As the process of education extends beyond the formal classroom, this article focuses on out-of-class (OOC) communication between faculty and students. A study exploring the roles of student sex and instructor sex, as well as student perceptions of instructor empathy and credibility in OOC was conducted. The results of the study indicate that empathy, credibility and sex of student and instructor all influence the amount and kinds of OOC communication that occur. As ratings of instructor empathy and credibility rise, students are more likely to engage in OOC communication, and this pattern is particularly pronounced for female students. Also, a same-sex preference for OOC communication was found. Implications and directions for further research are included.
The association between knowledge and attitudes about genetic testing for cancer risk in the United States.

Attitudes about genetic testing are likely to be an important determinant of uptake of predictive genetic tests among the general public. Several prior studies have suggested that positive attitudes about genetic testing may be inversely related to knowledge about genetic testing. We conducted a random-digit-dialing (RDD) telephone survey of 961 adults in the continental United States to determine the associations among knowledge of, attitudes about, and perceptions of eligibility for genetic testing for cancer risk. Knowledge about genetic testing for cancer risk was generally high, with a mean accuracy score of 72%. Attitudes about genetic testing for cancer risk were also generally positive, with 87% of respondents reporting genetic testing for cancer risk would be used to help doctors manage their health care and 85% to help scientists find cures for diseases. In contrast, 58% of respondents thought genetic testing for cancer risk would be used to prevent them from getting health insurance and 31% to allow the government to label groups as inferior. Twenty-nine percent of respondents thought they were currently eligible for testing. After adjustment for sociodemographic characteristics and family cancer history, higher knowledge was correlated with more positive attitudes about testing, but not with negative attitudes or perceptions of testing eligibility. Family history was positively associated with perceptions of eligibility (OR 3.49, 95%CI 2.36–5.18), and higher levels of education were inversely associated with perceptions of eligibility (OR 0.55, 95%CI 0.32–0.94 for comparison of college or higher vs. less than high school). These results suggest that most members of the general public are knowledgeable and have positive attitudes about genetic testing for cancer risk and that greater knowledge is correlated with more positive attitudes about the benefits of testing.
Cardiac and peripheral vascular effects of digitalis in clinical cardiogenic shock

Abstract The hemodynamic effects of cardiac glycosides were studied in 13 patients with cardiogenic shock. Intravenous administration of ouabain, deslanoside, or digoxin produced a prompt pressor effect which was characterized by increases in systemic vascular resistance and tension time index and no change or increase in right atrial pressure (RAP) and left ventricular enddiastolic pressure (LVEDP). Acute pulmonary edema developed during this period in one patient. During the later phase, 15 to 60 minutes after infusion of digitalis, there were increases in the maximum rate of rise of left ventricular pressure (LV dp dt ), mean systolic ejection rate, and left ventricular stroke work usually with a fall in RAP or LVEDP. Despite the evidence of improved myocardial function, cardiac output (CO) was not significantly increased and was always lower than that attained during infusion of isoproterenol. It is concluded that digitalis is not very effective by itself in restoring blood flow in cardiogenic shock and that the early peripheral vasoconstrictor effect following intravenous administration may be deleterious in some patients.
The Role of Radiation Therapy in the Management of Dermatofibrosarcoma Protuberans

Abstract Purpose: To evaluate the outcome for dermatofibrosarcoma protuberans treated with conservation surgery and radiation therapy. Methods and Materials: A retrospective review was performed of 19 consecutive patients with pathologically confirmed dermatofibrosarcoma protuberans who received radiation as an adjuvant to surgical resection. Results: The patients ages ranged from 19–76 years (median, 40 years); 12 were men. Lesions were located on the trunk in 8, in the head and neck area in 7, and in an extremity in 4. Tumor size ranged from 1.2 to 15 cm (median, 4 cm). Ten patients had at least 1 prior recurrence following earlier resection. Two patients received preoperative radiation to 50 Gy in 5 weeks. Sixteen patients underwent resection followed by radiation (6 of these had positive resection margins). In another patient, the tumor regrew rapidly after resection and definitive radiation was delivered for gross disease. The 6 patients with positive microscopic margins received a median dose of 60 Gy, as did the 10 with negative margins. The 1 patient with gross disease received 65 Gy. At a median follow-up of 6 years, the only patient to develop local recurrence was treated with definitive radiotherapy for gross disease. Actuarial local control was 95% at 10 years. Conclusion: Dermatofibrosarcoma protuberans is a radioresponsive tumor and radiation to doses of 50–60 Gy should be considered as an adjuvant to resection if margins are positive. Combined conservation resection and postoperative radiation should also be considered for situations where adequate wide excision alone would result in major cosmetic or functional deficits.
Integrated strain sensor for micromachined terahertz on-wafer probe

This paper introduces an improved method for monitoring and controlling the contact condition of terahertz on-wafer probes. This method enables accurate contact force measurement without modification to the standard probe station. Repeatable probe contact force is crucial for RF measurement repeatability and can be achieved by properly monitoring and controlling the strain generated at designated positions on the terahertz probe due to probe deformation induced by contacting the test substrate. A WR-1.5 (500 GHz-750 GHz) probe with integrated strain sensor is developed and tested. Measurement results of the WR-1.5 probe using 11 mN contact force controlled separately by load cell and strain sensor are presented.
Soot blowing optimization system and application to oil-fired boiler

The paper presents a method for the soot blowing optimization and its pilot application to the oil fired boiler of a power plant. The important monitored parameter of each steam generator is the thermal efficiency or the heat rate. These parameters are influenced by many factors, including for example the boiler design, control strategy, fuel quality, operating conditions, etc. The quality of the heat transfer between the flue gas and steam (water, water/steam mixture) is affected by soot, ash, and slag deposit (fouling) on the individual heat exchange surfaces. To avoid the negative effect of fouling, it is necessarily to clear the surfaces periodically. The objective of the soot blowing optimization system is to optimize this cycle and to provide recommendation to the plant operator. Proposed sootblowing optimization system monitors the process variables, estimates the fouling status of heat exchange surfaces, evaluates impact on economy and triggers the sootblowing sequence.
Recombination and migration of Cryphonectria hypovirus 1 as inferred from gene genealogies and the coalescent

Genealogy-based methods were used to estimate migration of the fungal virus Cryphonectria hypovirus 1 between vegetative compatibility types of the host fungus, Cryphonectria parasitica, as a means of estimating horizontal transmission within two host populations. Vegetative incompatibility is a self/non-self recognition system that inhibits virus transmission under laboratory conditions but its effect on transmission in nature has not been clearly demonstrated. Recombination within and among different loci in the virus genome restricted the genealogical analyses to haplotypes with common mutation and recombinational histories. The existence of recombination necessitated that we also use genealogical approaches that can take advantage of both the mutation and recombinational histories of the sample. Virus migration between populations was significantly restricted. In contrast, estimates of migration between vegetative compatibility types were relatively high within populations despite previous evidence that transmission in the laboratory was restricted. The discordance between laboratory estimates and migration estimates from natural populations highlights the challenges in estimating pathogen transmission rates. Genealogical analyses inferred migration patterns throughout the entire coalescent history of one viral region in natural populations and not just recent patterns of migration or laboratory transmission. This application of genealogical analyses provides markedly stronger inferences on overall transmission rates than laboratory estimates do.
Thermodynamics of proton dissociations from aqueous threonine and isoleucine at temperatures from (278.15 to 393.15) K, molalities from (0.01 to 1.0) mol kg- 1, and at the pressure 0.35 MPa : Apparent molar heat capacities and apparent molar volumes of zwitterionic, protonated cationic, and deprotonated anionic forms

We have measured the densities of aqueous solutions of isoleucine, threonine, and equimolal solutions of these two amino acids with HCl and with NaOH at temperatures 278.15 ⩽ T /K ⩽ 368.15, at molalities 0.01 ⩽ m /mol · kg −1 ⩽ 1.0, and at the pressure 0.35 MPa using a vibrating tube densimeter. We have also measured the heat capacities of these solutions at 278.15 ⩽ T /K ⩽ 393.15 and at the same m and p using a twin fixed-cell differential temperature-scanning calorimeter. We used the densities to calculate apparent molar volumes V ϕ and the heat capacities to calculate apparent molar heat capacities C p , ϕ for these solutions. We used our results and values from the literature for V ϕ ( T , m ) and C p , ϕ ( T , m ) for HCl(aq), NaOH(aq), and NaCl(aq) and the molar heat capacity change Δ r C p ,m ( T , m ) for ionization of water to calculate parameters for Δ r C p ,m ( T , m ) for the two proton dissociations from each of the protonated aqueous cationic amino acids. We used Young’s Rule and integrated these results iteratively to account for the effects of equilibrium speciation and chemical relaxation on V ϕ ( T , m ) and C p , ϕ ( T , m ). This procedure gave parameters for V ϕ ( T , m ) and C p , ϕ ( T , m ) for threoninium and isoleucinium chloride and for sodium threoninate and isoleucinate which modeled our observed results within experimental uncertainties. We report values for Δ r C p ,m , Δ r H m , pQ a , Δ r S m , and Δ r V m for the first and second proton dissociations from protonated aqueous threonine and isoleucine as functions of T and m .
Patterns of E74A RNA and protein expression at the onset of metamorphosis in Drosophila

Metamorphosis in Drosophila is triggered by a pulse of the steroid hormone ecdysone at the end of larval development. Ecdysone initiates a genetic hierarchy that can be visualized as a series of puffs in the larval salivary gland polytene chromosomes. The E74 gene is responsible for the early ecdysone-inducible puff at position 74EF and encodes two related DNA-binding proteins which appear to play a regulatory role in the hierarchy. Here we describe the spatial and temporal patterns of E74A RNA and protein expression at the onset of metamorphosis. We use in situ hybridization, antibody stains, and western and northern blot analyses to follow E74A expression from its initial appearance as nascent transcripts on the polytene chromosomes, to spliced mRNA, to post-translationally modified nuclear E74A protein. E74A is expressed in a wide variety of late-third instar tissues, suggesting that it plays a broad pleiotropic role in response to the hormone. In early prepupae, when the overall levels of E74A mRNA are decreasing, relatively high levels of E74A RNA persist in the gut, peripodial membranes of the imaginal discs, and proliferation centers of the brain. The spatial distribution of nuclear E74A protein correlates with the RNA distribution with the single exception that no E74A protein can be detected in the proliferation centers of the brain. There is also a temporal discrepancy between E74A mRNA and protein accumulation. The peak of E74A protein induced by the late larval ecdysone pulse follows the peak of E74A mRNA by approximately 2 h. This delay is not seen in 10 h prepupae, when the next pulse of ecdysone induces the simultaneous expression of E74A mRNA and protein. We discuss possible mechanisms for post-transcriptional regulation of E74A expression and suggest that the unusually long and complex 5′ leader in the E74A mRNA may regulate its translation.
Determination of Serum Albumin with the "SMA 12/60" by a Bromcresol Green Dye-Binding Method

A bromcresol green (BCG) method for serum albumin has been adapted to the Technicon "SMA 12/60." Sensitivity and linearity critically depend on the concentrations of BCG and surfactant ("Brij-35"). With appropriate concentrations, linearity to 6.0 g/dl is achieved. Interaction is 2-3%. Standard deviations for quality control pools of 2.0 and 4.7 g/dl during three months of routine service were 0.06 and 0.11 g/dl. Values agree well with values determined by the Du Pont "ACA" (bias = 0.047 g/dl, SD = 0.191 g/dl, t = 1.746, r = 0.975, n = 53), by a modified Beckman "DSA" method in which BCG is also used (bias = 0.006, SD = 0.164, t = 0.398, r = 0.976, n = 115), and by electrophoresis on cellulose acetate (bias = 0.028, SD = 0.203, t = 1.006, r = 0.961, n = 54). Blank errors for hemolyzed samples (plasma hemoglobin up to 350 mg/dl), icteric samples (bilirubin up to 30 mg/dl), and lipemic samples (triglycerides up to 500 mg/dl) are 0.2 g/dl or less when the blank channel is not used. Normal range is estimated to be 3.5 to 4.8 g/dl (n = 145; 2.5 and 97.5 percentiles).
Moduli spaces of sheaves on K3 surfaces

Abstract In this survey article we describe moduli spaces of simple, stable, and semistable sheaves on K3 surfaces, following the work of Mukai, O’Grady, Huybrechts, Yoshioka, and others. We also describe some recent developments, including applications to the study of Chow rings of K3 surfaces, determination of the ample and nef cones of irreducible holomorphic symplectic manifolds, and moduli spaces of Bridgeland stable complexes of sheaves.
Relationship of Seasonal Activity of Dermacentor albipictus (Acarina: Ixodidae) to Photoperiod: a Laboratory Study

The adult, egg, and larva of the winter tick, Dermacentor albipictus (Packard), were held at 27°C with 0, 8, 12, or 16 hr of light per 24 hours to determine the photosensitive stage. The rate of attachment was used as the criterion of diapause larvae. Exposure of eggs to short days was conducive to nondiapause larvae until the larvae were as much as 5 weeks old. Exposure of larvae to long days induced diapause; exposure to short days inhibited diapause. The relationship between larval age and diapause was highly significant because the rate of attachment of older larvae was higher. Larval diapause began to terminate spontaneously after 11 weeks in all photoperiods. The mechanism of diapause and its relationship to the sensitivity of D. albipictus to light are therefore primary factors affecting the seasonal activity of this species.
Deformation mechanisms in commercial TI-5Al-2.5 Sn (0.5 At. pct Oeq) alloy at intermediate and high temperatures (0.3-0.6 tm)

The plastic flow of the commercial α-alloy Ti 5A1-2.5 Sn (0.5 at. pct Oeq) of 11 to 19 μm grain size was investigated in tension over the temperature range of 600 to 117.3 K (CPH structure) and strain rates of 3x10-5 to 3 per s employing both constant strain rate and strain rate cycling tests. Dynamic strain aging (due to substitutional solutes) occurred in the temperature range of 600 to 850 K (0.31 to 0.44T m)with an activation energy of 22.5 KcalJmole (94.1 KjJmol) derived from the start of serrations in the stress-strain curves. At temperatures above 850 K (0.46 to 0.60T m), the deformation could be described by Dorn’s general equation for diffusion controlled mechanisms with an activation energy of 50 KcalJmole (209 KJJmol).
Bulk Transport and Interfacial Transfer Dynamics of Photogenerated Carriers in CdSe Quantum Dot Solid Electrodes

Practical solar-to-fuel conversion applications of quantum-confined semiconductor crystals require their integration into electrodes. We show that photogenerated electrons in quantum dot solid electrodes can be transported to the aqueous interface to reduce methyl viologen with 100% quantum efficiency and an effective time constant of 12 ± 2 ps. The charge separated state had a half-life of 200 ± 10 ns, limited by hole transport within the solid.
Exploring Eating and Activity Behaviors with Parent–Child Dyads Using Event History Calendars

Despite advances in science, the prevalence of childhood obesity persists and outcomes remain inconsistent. An event history calendar (EHC) is a tool to facilitate understanding of family life dynamics influencing eating and activity choices. This tool uses reflection to assess temporally linked behavior in the context of life events so that choices related to eating and activity are more explicit. Fourteen parent-child (6-14 years) dyads completed an EHC and interview 2 months following a healthy eating/activity intervention. Phenomenological analysis revealed themes including "awareness" of activity/eating behaviors, "healthy lessons," "family time," and "barriers" to change. The EHC facilitated participant communication and understanding by making connections between behaviors, habits, and events in family context, so that eating and activity behaviors could be realistically reviewed. This tool has potential to guide development of individualized interventions through barrier identification and goal establishment in research and clinical settings to help counteract childhood obesity over time.
How do you do it

tounding display of affection at the service. Shaking her head, her eyes filled with tears, she said, "I don't know how you do what you do." "How do you do it?" is something that, I suspect, all of us in the healthcare professions have heard at one time or another. How many of our friends and family simply cannot fathom the horror of traumas that we see daily as part of our "normal" routine, our familiarity with diseases like cancer and mental illness that they find impossible to imagine? But this time, the questioner was not an uninitiated lay person; she is a skilled nurse with many years of emergencydepartment experience. Her comment-referring to the fact that my caseload consists heavily of people with AIDS-came from knowing that I had lost, within three weeks of each other, my life partner and my best friend to AIDS, and that, as a gay man, I could hardly count the number of friends and acquaintances this monster illness had taken away. I was surprised to find my response taking me back to college nearly 20 years ago and to something Jean-Paul Sartre wrote on the subject of the Nazi occupation of France. Sartre argued that the French people "were never more free than under the German Occupation." So completely devastated were their lives, he believed, that their every action-indeed, their every thoughtwas raised to the level of a battle between freedom and acquiescence, between life and death. Wrote Sartre,
Utilization of Lunar Resources for Human Mars Missions

Proposed human missions to Mars require a large initial mass in low Earth orbit (IMLEO). Delivering this mass to orbit requires several launches of a heavy lift launch vehicle, such as the previously proposed Ares V, or many launches of a smaller vehicle and significant on-orbit assembly. A significant fraction of the launch mass is propellant for the in-space propulsion system. Removing the propellant mass from the launch manifest has the potential to significantly reduce the number of launches required for a Mars mission. One proposed method for replacing the launched propellant is to utilize propellant manufactured from lunar resources. If it is possible to produce the oxygen required from lunar regolith, and deliver it to the Mars transfer vehicles (MTV) in an economical manner, dramatic cost savings for the overall architecture could be realized. This study examined the requirements for the manufacture and transport of oxygen from lunar regolith for the fueling of a hydrogen-oxygen MTV. The goal of the study was to determine what combination of architectural elements best facilitates the use of lunar derived resources for production of propellant for the MTV. The relevant surface and transportation systems were modeled, with several different architectures considered under a variety of assumptions. These various architectures were compared to two baselines: the nuclear thermal rocket driven MTVs from the Mars Design References Architecture 5.0, and a chemical propulsion baseline modeled using this study’s tools, with all of the propellant launched from the Earth’s surface. The bases for comparison included the estimated cost of the architectures, the reliability of the architectural elements, and the total launch manifest required for a multi-mission campaign. It was found that under an optimistic set of assumptions, one architecture outperformed both baselines, while three In-Situ Resource Utilization (ISRU) architectures outperformed the nuclear baseline.
The Inescapably Empirical Foundation of the Common Law of Corporations

Common law adjudication has always involved the formulation of legal standards by judges based on assumptions about how the world works. In this essay, which was delivered as the keynote address for the Second Annual Law and Business Program Conference at Vanderbilt University Law School, the author focuses on the importance of empirical facts in the evolution of the common law of corporations. Using doctrinal examples drawn from recent cases, the essay demonstrates that many important standards in corporate law rest on factual intuitions that are not case-specific, but which instead involve more general understandings about how human beings behave in various market and institutional settings. As a result, the author argues that it is more, rather than less, important for corporate law judges to seek to acquire knowledge about real-world behavior, to expose their reasoning openly, and to be willing to change course if experience and evolutions in the commercial world suggest that modifications in prior doctrine are warranted.
Where/How Does Marketing Fit? What Is Marketing’s Place in the Firm and Within the Family of Business Disciplines?

In the early 1980s, the Academy of Management Review commissioned a set of articles to assess the contributions of various business disciplines to strategic management. These assessments included evaluations of contributions from industrial organization (Porter 1981), administrative behavior (Jemison 1981), and marketing (Biggadike 1981). Biggadike’s conclusions, judged marketing to be theoretically thin, giving him little hope for change in the future.
Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer.

Background Patients with locally advanced esophageal cancer who are treated with trimodality therapy have a high recurrence rate. Preclinical evidence suggests that inhibition of cyclooxygenase 2 (COX2) increases the effectiveness of chemoradiation, and observational studies in humans suggest that COX-2 inhibition may reduce esophageal cancer risk. This trial tested the safety and efficacy of combining a COX2 inhibitor, celecoxib, with neoadjuvant irinotecan/cisplatin chemoradiation.
Immunoglobulin G4-related sclerosing disease of the paranasal sinuses: A case report and literature review.

ObjectiveImmunoglobulin G4 (IgG4) related sclerosing disease (RSD) of the paranasal sinuses is a rare lesion of dense lymphoplasmacytic tissue, with a high proportion of IgG4+ plasma cells. We pres...
Tom and Nicole, A Couple in Distress

SUMMARY This paper examines the movie Eyes Wide Shut from a couples therapy standpoint. ft attempts to analyze the wife's motivation in describing to her husband both her adulterous fantasy and a dream in which she has multiple sexual partners. The paper also analyzes the husband's acting out after hearing her fantasy. The paper looks at this material in terms of Freud's unconscious dream mechanisms, condensation, displacement and symbolization, and the meaning of manifest and latent content in the understanding of dreams.
Infinite dimensional regime-switching stochastic approximation algorithms

We analyze a type of stochastic approximation algorithms with regime switching modulated by a discrete Markov chain having countable state spaces and two-time-timescale construction. In the algorithm, the increments of a sequence of occupation measures are updated using constant step size iterates. We show that least squares estimates of the tracking errors can be developed. Under the assumption that the adaptation rates have the same magnitude as that of times-different parameter, we prove the continuous-time interpolation from the iterates converges weakly to a system of ordinary differential equations with regime switching. In addition, we demonstrate that the suitably scaled sequence of the tracking errors converges to a system of switching diffusions.
Logical and Philosophical Foundations of Experimental Research in the Social Sciences

Abstract: This chapter outlines the logical and philosophical underpinnings of contemporary experimental research in the social sciences. After explicating the fundamental principles of experimental design and analysis as established by John Stewart Mill and Ronald A. Fisher, I examine modern critiques of the experimental method and show how these are flawed. Along the way, I consider how scientists think about causality, issues of internal and external validity, empirical versus theoretical experimentation, and the many varieties of experimental design.
Electronic structure of CuTeO4 and its relationship to cuprates

Based on first-principles calculations, the electronic structure of ${\mathrm{CuTeO}}_{4}$ is discussed in the context of superconducting cuprates. Despite some significant crystallographic differences, we find that ${\mathrm{CuTeO}}_{4}$ is similar to these cuprates, exhibiting a quasi-two-dimensional electronic structure that involves hybridized Cu-$d$ and O-$p$ states in the vicinity of the Fermi level, along with an antiferromagnetic insulating ground state. Hole-doping this material by substituting ${\mathrm{Te}}^{6+}$ with ${\mathrm{Sb}}^{5+}$ would be of significant interest.
Children Adopt the Traits of Characters in a Narrative

Adults adopt the traits of characters in narratives, but little is known about whether children do so. In Study 1, 7- and 10-year-olds ( ) heard a 2.5-minute recording about a professor or cheerleader. Reporting higher engagement in the professor narrative related to more time playing with an analytical toy (a Rubik’s cube), whereas reporting higher engagement in the cheerleader narrative related to less time playing with Rubik’s cube. However, although children were randomly assigned to a narrative, within condition children may have had preexisting personality differences causing them both to become more engaged in that narrative and also to behave more like that character afterwards. To control for this possibility, in Study 2 children ( ) were given perspective-taking or objective instructions. Interestingly, both instructions created higher engagement than in Study 1, resulting in main effects of narrative. Children in the professor condition, compared to those in the cheerleader condition, spent more time playing with Rubik’s cube and self-reported higher levels of professor-relevant characteristics (e.g., smart, good at teaching). These studies show that, by the elementary school years and particularly when highly engaged in a narrative, children adopt the traits of a narrative’s central character.
Concomitant Left Atrial Myxoma and Patent Foramen Ovale: Is It an Evolutional Synergy for a Cerebrovascular Event?

We report a case of a 48-year-old female who presented initially with an abrupt onset of left facial and hand numbness after her routine yoga with no associated syncope, palpitation, chest pain or dyspnea. She consulted her primary care physician and recommended hospital care for possible stroke. On the day of admission, she complained of left facial and hand hemiparesthesia. Cranial imaging and angiography were unremarkable but echocardiography and cardiac computed tomography revealed left atrial mass. She underwent resection of the left atrial mass with an incidental finding of patent foramen ovale intraoperatively. The left atrial mass was confirmed to be an atrial myxoma. Patient’s neurologic complaints resolved towards the end of her hospital course. She was discharged stable with no recurrence of neurologic symptoms on health maintenance evaluation. Cardiol Res. 2017;8(1):26-29 doi: https://doi.org/10.14740/cr522w
Stability of 30 Fatty Acids in Serum Stored at -20 °C for up to 5 Years.

To the Editor: Stability studies have shown that fatty acids in serum cholesteryl ester (CE),1 triglyceride (TG), and phospholipid (PL) fractions stored at −80 °C are stable for up to 10 years (1); but data on the stability of unfractionated serum fatty acids stored at −80 °C or −20 °C are lacking. Polyunsaturated fatty acids (PUFAs), which are highly sensitive to oxidative degradation, were decreased by 14%–46% in plasma CE, TG, and PL fractions stored for 3 years at −20 °C (2). Butylated hydroxytoluene (BHT) has been tested as an antioxidant to prevent fatty acid degradation. Fatty acids in …
Resolution of vocal fold immobility in preterm infants

Abstract Introduction Vocal fold immobility (VFI) is an important sequela of preterm birth due to patent ductus arteriosus (PDA) ligation and invasive ventilation. A minority of these patients experience VFI resolution. The purpose of this study is to determine factors associated with VFI resolution in preterm infants. Methods This is a case control study of preterm ( Results Of 71 patients with VFI and adequate follow-up, 17 (23.9%) experienced resolution. Median (range) follow-up was 25.7 (0.4–91.3) months and time to resolution 4.4 (0.4–38.8) months. Compared to the ongoing-VFI cohort, those who experienced resolution had higher median gestational age (31 vs 25 weeks, p = 0.006) and birth weight (1550 vs 765 g, p = 0.02), and lower likelihood of undergoing PDA ligation (47.1% vs 77.8%, p = 0.02). On multivariate analysis, history of PDA ligation remained independently associated with a lower likelihood of VFI resolution (p = 0.02, OR 0.2, 95% CI 0.1–0.8). Among PDA ligation patients, birth weight >1000 g was more common in the resolution cohort compared to the ongoing-VFI cohort (62.5% vs 24.4%, p = 0.047). Conclusion While lower birth weight and gestational age are known risk factors for VFI following PDA ligation, in this study, these factors were also associated with a decreased likelihood of VFI resolution. Furthermore, PDA ligation appears to be a risk for both the development and persistence of VFI. This evidence should inform prognosis and intervention decisions for preterm infants with VFI.
Multi-Dimensional Infrastructure Resilience Modeling: An Application to Hurricane-Prone Electric Power Distribution Systems

Despite the scientific consensus on the multivariate nature of resilience, the majority of the existing approaches either focus on modeling a single dimension of resilience, or model its various dimensions separately. In this paper, we propose leveraging one of the most recent advances in statistical machine learning to characterize the multivariate inoperability of an electric power distribution system as a non-linear function of the system’s topology, hurricane hazard characteristics, and the service area’s climate and topography. The model can then be used as a predictive tool to assess various investment strategies for enhancing the multivariate resilience of the system. The results established the number of customers served, tree-trimming frequency, hurricane intensity, land-cover types, and soil moisture as the key predictors of the distribution system’s multivariate inoperability. The variable influence heat-map helped identify the clusters of predictors that jointly influence one or more measures of inoperability. Moreover, the partial dependence plots were leveraged to examine the non-linear relationships between the focal predictors and the various measures of hurricane impact. The estimated multivariate inoperability model was then used to assess resilience enhancement strategies. The proposed approach can help infrastructure managers and urban planners to approximate the multivariate resilience of infrastructure holistically, predict the system’s resilience under various stochastic perturbation regimes, and identify effective strategies to improve the overall resilience of the system.
Liquid Silicon-Monona: A Reconfigurable Memory-Oriented Computing Fabric with Scalable Multi-Context Support

With the recent trend of promoting Field-Programmable Gate Arrays (FPGAs) to first-class citizens in accelerating compute-intensive applications in networking, cloud services and artificial intelligence, FPGAs face two major challenges in sustaining competitive advantages in performance and energy efficiency for diverse cloud workloads: 1) limited configuration capability for supporting light-weight computations/on-chip data storage to accelerate emerging search-/data-intensive applications. 2) lack of architectural support to hide reconfiguration overhead for assisting virtualization in a cloud computing environment. In this paper, we propose a reconfigurable memory-oriented computing fabric, namely Liquid Silicon-Monona (L-Si), enabled by emerging nonvolatile memory technology i.e. RRAM, to address these two challenges. Specifically, L-Si addresses the first challenge by virtue of a new architecture comprising a 2D array of physically identical but functionally-configurable building blocks. It, for the first time, extends the configuration capabilities of existing FPGAs from computation to the whole spectrum ranging from computation to data storage. It allows users to better customize hardware by flexibly partitioning hardware resources between computation and memory, greatly benefiting emerging search- and data-intensive applications. To address the second challenge, L-Si provides scalable multi-context architectural support to minimize reconfiguration overhead for assisting virtualization. In addition, we provide compiler support to facilitate the programming of applications written in high-level programming languages (e.g. OpenCL) and frameworks (e.g. TensorFlow, MapReduce) while fully exploiting the unique architectural capability of L-Si. Our evaluation results show L-Si achieves 99.6% area reduction, 1.43× throughput improvement and 94.0% power reduction on search-intensive benchmarks, as compared with the FPGA baseline. For neural network benchmarks, on average, L-Si achieves 52.3× speedup, 113.9× energy reduction and 81% area reduction over the FPGA baseline. In addition, the multi-context architecture of L-Si reduces the context switching time to - 10ns, compared with an off-the-shelf FPGA (∼100ms), greatly facilitating virtualization.
The Role of Hemocytes in Melanotic Tumor Formation

The diseases of insects may be grouped in two main categories: those in which the pathological syndrome is generated by the presence of an inf ect ive agent, and those in which a genetic defect underlies the pathological condition. Hemocytes are involved in combating deleterious effects in both cases. In the case of infection we can be certain that the hemocytes are reacting to stimuli emitted by the presence of the infective agent. Cell-mediated defense responses of insects to foreign bodies in the hemocoel include phagocytosis and nodule formation by the hemocytes (Salt, 1970). Similar types of behavior are exhibited by hemocytes in some genetic diseases (Oftedal, 1953). However, in the latter cases, analysis of the pathological syndrome is complicated by the dif ficulty in determining whether the genetic lesion directly affects the hemocytes or the hemocytes are reacting to gene-conditioned disorders elsewhere in the body.
Treatment of adult acute myeloblastic leukemia.

The introduction of combination chemotherapy in the treatment of adult acute leukemia has had a profound impact on the response and duration of survival of patients with adult acute myeloblastic leukemia. In the past decade, the combination of cytosine arabinoside with an anthracycline antibiotic, either daunorubicin, adriamycin, or rubidazone, has been responsible to a large degree for the success.
Building a conversational simstudent

SimStudent, an intelligent-agent architecture that generates a cognitive model from worked-out examples, currently interacts with human subjects only in a limited capacity. In our application, SimStudent attempts to solve algebra equations, querying the user about the correctness of each step as it solves, and the user explains the step in natural language. Based on that input, SimStudent can choose to ask further questions that prompt the user to think harder about the problem in an attempt to elicit deeper responses. We show how text classification techniques can be used to train models that can distinguish between different categories of student feedback to SimStudent, and how this enables interaction with SimStudent in a pilot study.
Effectiveness of altering serum cholesterol levels without drugs.

Drug therapy with statins and other agents can result in dramatic lipid-lowering effects. Despite the wealth of data supporting the beneficial effects of pharmacologic therapy on cardiovascular ris...
Problem-Oriented Approach to Diagnosis and Treatment in Liaison Psychiatry

The problem-oriented approach to diagnosis and treatment of biopsychosocial disturbances is an extension of the experience with problem-oriented records. These were originally introduced for the sake of record-keeping among medical patients in general hospitals and then adapted for use in psychiatry. They can also be very useful in liaison work.
Beyond the Cap Rate: Valuation of Multifamily Properties

Estimating the value of multifamily properties and other commercial real estate properties is an important but difficult task for real estate investors and researchers. The commonly used capitalization rate model, which involves the estimation of capitalization rates, has limitations in practice, especially during periods of financial stress. This paper proposes a new property valuation methodology that directly estimates the value of multifamily properties by accounting for both market trends and property operating performance. Our results show that this new model significantly improves the valuation of multifamily properties, particularly distressed properties. This methodology can also be applied to the valuation of other commercial real estate properties.
Showcasing Optimization Model for Hyperconnected Showcasing Centers

Abstract Although the rise of e-commerce encourages the customers to order online and get the products shipped from the warehouse, for high value goods they still want to experience the product in person to gain confidence in their purchase. Furthermore, with the Physical Internet and highly efficient, interconnected networks, goods can be delivered fast and reliably, enabling the showcasing model to be an integral part of the supply chain. Goods do not need be stored in retail shops anymore as they can be shipped from available connected sources. Such changes accentuate the role of showcasing, and a decision support system to optimize the showcase that best meet customer’s expectation is needed. We thus propose a model for measuring and optimizing the showcasing value for a retailer, specifically focusing on recreational vehicle dealerships as an illustrative example. Even when the exact desired features are not available, the customer can gain partial confidence from similar features. We first introduce the concept of showcasing value. The showcasing optimization problem is then formulated as a mixed integer programming problem, where the objective function maximizes the sum of showcase representation value for all features in the showroom, given the feature demand shares and the weight of the feature categories. Computational experiments are conducted with data from the industry, focusing on dealerships in a region in United Sates. Our results indicate that a significant increase in the showcasing value can be achieved through an optimized showcase with little or no extra budget.
Rate Estimation and Identification of COVID-19 Infections: Towards Rational Policy Making During Early and Late Stages of Epidemics

Pandemics have a profound impact on our world, causing loss of life, affecting our culture and historically shaping our genetics. The response to a pandemic requires both resilience and imagination. It has been clearly documented that obtaining an accurate estimate and trends of the actual infection rate and mortality risk are very important for policy makers and medical professionals. One cannot estimate mortality rates without an accurate assessment of the number of infected individuals in the population. This need is also aligned with identifying the infected individuals so they can be properly treated, monitored and tracked. However, accurate estimation of the infection rate, locally, geographically and nationally is important independently. These infection rate estimates can guide policy makers at both state, national or world level to achieve a better management of risk to society. The decisions facing policy makers are very different during early stages of an emerging epidemic where the infection rate is low, middle stages where the rate is rapidly climbing, and later stages where the epidemic curve has flattened to a low and relatively sustainable rate. In this paper we provide relatively efficient pooling methods to both estimate infection rates and identify infected individuals for populations with low infection rates. These estimates may provide significant cost reductions for testing in rural communities, third world countries and other situations where the cost of testing is expensive or testing is not widely available. As we prepare for the second wave of the pandemic this line of work may provide new solutions for both the biomedical community and policy makers at all levels.
Association between longest-held occupation and Social Security Disability Insurance benefits receipt.

INTRODUCTION The cost of the Social Security Disability Insurance (DI) program has increased over time though recent reports showed that disability incidence and prevalence rates have started declining. We explored whether occupation was one of the risk factors for the rising number of disabled workers who received DI benefits during 1992-2016. METHODS We used a cohort of 16 196 Health and Retirement Survey respondents between the age of 51 and 64 years who were followed from their date of entry until they received DI benefits, died, reached full retirement age, or reached the end of the follow-up period (2016). We used the extended stratified Cox proportional hazard model. Because one-third of the respondents in our cohort did not report their longest-held occupation, we used a multiple-imputation method. RESULTS The hazard of receiving DI benefits was 51%, 78%, 81%, and 85% higher among workers with longest-held occupations in sales, mechanics and repair, protective services, and personal services, respectively than among workers with longest-held occupations in the reference managerial occupation. The hazard of receiving DI benefits was more than double among workers with longest-held occupations in the construction trade and extractors, transportation operation, machine operators, handlers, and food preparation than among workers with the longest-held occupation in the reference managerial occupation. CONCLUSION Improving the overall working conditions in these occupations would help reduce worker suffering and the number of applicants for DI benefits, thereby reducing the burden of workplace injury and illness on the DI program.
Specifying and Mitigating Thermal Stress Effects on Cognition During Personal Protective Equipment Use.

ObjectiveTo report present understanding concerning selected task and environmental factors influencing the changing performance capacity associated with use of personal protective equipment (PPE)....
Constraints to Arizona agriculture and possible alternatives

In Arizona, groundwater belongs to the owner of the land overlying the aquifer. To ensure adequate municipal groundwater supplies, the City of Tucson has been purchasing and retiring farmlands. While this is an effective technique, it has a significant impact on the economy of the area. One possible alternative to retiring farmlands and to cultivation of high-water-use crops is the cultivation of arid-adapted vegetation with economic potential. Jojoba (Simmondsia chinensis) is a shrub native to the Sonoran Desert that appears to be an economically-viable arid lands crop. Jojoba oil, extracted from the seed, is a unique, unsaturated oil composed of non-glyceride esters consisting almost entirely of straight-chain acids and alcohols. Such oils are difficult to synthesize in commercial quantities, and the only other known natural source is the sperm whale, an endangered species. Water requirements for jojoba production are approximately 4600 m3 per hectare compared with traditional crops grown in the area with average requirements of 12,315 m3 per hectare or more.