cssi/SciSciGPT-SciSciNet huggingface dataset:
Phonotactic and Prosodic Effects on Word Segmentation in Infants

This research examines the issue of speech segmentation in 9-month-old infants. Two cues known to carry probabilistic information about word boundaries were investigated: Phonotactic regularity and prosodic pattern. The stimuli used in four head turn preference experiments were bisyllabic CVC.CVC nonwords bearing primary stress in either the first or the second syllable (strong/weak vs. weak/strong). Stimuli also differed with respect to the phonotactic nature of their cross-syllabic C.C cluster. Clusters had either a low probability of occurring at a word juncture in fluent speech and a high probability of occurring inside of words ("within-word" clusters) or a high probability of occurring at a word juncture and a low probability of occurring inside of words ("between-word" clusters). Our results show that (1) 9-month-olds are sensitive to how phonotactic sequences typically align with word boundaries, (2) altering the stress pattern of the stimuli reverses infants' preference for phonotactic cluster types, (3) the prosodic cue to segmentation is more strongly relied upon than the phonotactic cue, and (4) a preference for high-probability between-word phonotactic sequences can be obtained either by placing stress on the second syllable of the stimuli or by inserting a pause between syllables. The implications of these results are discussed in light of an integrated multiple-cue approach to speech segmentation in infancy.
Partial replacement of concentrate by high quality hay for cows in early lactation.

Abstract The objective was to evaluate the effect of partial replacement of concentrate with high quality hay in the diet of lactating cows. Basal forage components were long alfalfa hay and corn silage. In Trial 1, 30 Holsteins in early lactation were fed concentrates containing a ground legume-grass hay at 0, 20, and 33%. There were no differences in intake of dry matter, yields of milk or milk components, and changes in body weight. Glucose, urea nitrogen, and free fatty acids in blood and volatile fatty acids in rumen contents differed. In trial 2, six Holstein and three Brown Swiss cows were blocked into three groups in a 19-day measurement of digestibility and rate of passage of feeds. Alfalfa-grass hay in either ground or chopped form replaced 0 and 20% of concentrate. In a marker meal, concentrate portion was stained with basic fuchsin and the long hay portion with crystal violet. There were no differences in apparent digestion coefficients from concentrate replacement or form of forage. There were no marked differences in retention time for the long hay component. Concentrate with 20% substitution of ground forage passed through the digestive tract more rapidly than 0% substitution or that containing 20% chopped forage.
Heterogeneity of Elastin Expression in Cutis Laxa Fibroblast Strains

Abstract Cutis laxa is a genetically heterogeneous connective tissue disease that occurs in both inherited and acquired forms. The most apparent defect is loose, redundant, nonresilient skin, but systemic connective tissue abnormalities exist, especially in conjunction with the early onset or autosomal recessive variety. The elastic fiber shows morphologic alterations. We studied dermal skin biopsies and cultured skin fibroblasts from 6 patients with congenital forms of cutis laxa in an effort to correlate alterations in elastin morphology and metabolism. In general, ultrastructural analysis revealed occasional variance in collagen fiber diameter, whereas elastic tissue varied in content, appearance, and the proportion and manner by which elastin and microfibrillar component associated. Fibroblast cell lines comprised of normal donors from a similar age group produced an average of 35 ± 10 × 10 3 tropoelastin molecular equivalents per cell per hour, as measured by an ELISA. Three of six cutis laxa cell strains were markedly (5–20-fold) reduced in tropoelastin production. Two of these cell strains had specifically reduced levels of tropoelastin production relative to total protein synthesis. Analysis of elastin specific messenger RNA levels indicated this reduced expression of tropoelastin was regulated at a pretranslational level. In other strains, diminished production of elastin did not appear to be the primary defect, underscoring the heterogeneous nature of cutis laxa at both the biochemical and ultrastructural levels.
Exchange rate volatility and fluctuations in the extensive margin of trade

Abstract The existing evidence for exporters׳ entry and exit in response to exchange rate movements is based on either low frequency data or a sample with large devaluations. Using quarterly data of U.S. bilateral trade with 99 countries, this study provides new evidence that the extensive margin of trade fluctuates over the business cycle. First, I show that the extensive margin of exports to the U.S. and the extensive margin of imports from the U.S. are more volatile than the output of almost all trading partners. Next, I find that fixing exchange rates with the U.S. dollar, having a free trade agreement with the U.S., and an increase in country size is significantly associated with the stability of the pattern of trade with the U.S.
Endothelial dysfunction and cardiovascular disease

The endothelium, by area alone, is one of the largest organs in the body comprised of up to trillion cells, weighing over 1 kg, and covering nearly 3 m2 in a 70 kg male.1,2 Moreover, it interacts with nearly every system in the body, and has been implicated in end organ diseases of systems such as neurologic, renal, hepatic, vascular, dermatologic, immunologic, and of course cardiac. The endothelium is a single vessel layer standing as the ultimate layer between blood and vascular supply to other tissues, and serving multiple purposes. The first and foremost is a hemostatic balance between thrombosis and anticoagulation via a careful series of checks and balances discussed below. Additionally, the endothelium regulates vascular tone, carefully balancing vasoconstriction and vasodilation to provide adequate perfusion pressure to target organs. Other functions include regulation of angiogenesis, wound healing, smooth muscle cell proliferation, fibrosis, and inflammation. Factors that adversely affect the endothelium include common cardiovascular risk factors such as tobacco use, obesity, age, hypertension, hyperlipidemia, physical inactivity, and poor dietary habits. Alternatively, factors that positively impact the function of the endothelium are, essentially, beneficial lifestyle habits opposite to those mentioned above such as increased physical activity, dietary habits which include anti-inflammatory and anti-oxidant foods, and some pharmaceutical agents such as L-Arginine. Presently there is no guideline directive – either pro or con – to routinely include endothelial function testing in cardiovascular disease (CVD) risk assessment.3–5
Distributed System for Coastal Infrastructure Modeling and Assessment

The client/server computer architecture of the Internet provides an efficient mechanism for implementing effective civil infrastructure monitoring and assessment applications. Systems functionality that is enabled by this important technology includes remote and real-time data acquisition, distributed model execution and control, multiuser access to and monitoring of decision support systems, and efficient systems expansion and maintenance. With the dramatic increase in available infrastructure data and the continued improvement in the reliability and robustness of these technologies, widespread design, implementation, and use of distributed infrastructure modeling systems will become common. This paper describes the design and development of a prototype infrastructure modeling system incorporating these technologies that has recently been implemented to help decision makers manage the coastal infrastructure of the Great Lakes.
Etomidate versus pentobarbital for sedation of children for head and neck CT imaging.

Objectives: We compare etomidate to pentobarbital for sedation of children for head and neck computed tomography imaging. Methods: We performed a prospective, randomized, double-blinded trial of patients aged 6 months to 6 years enrolled from the emergency department or radiology department at a large urban children's hospital. The primary outcome measure was sedation success rate. Results: A total of 61 patients were enrolled in the study (27 etomidate group, 34 pentobarbital group) at 2 different dosing regimens for etomidate. The final analysis group included 17 etomidate patients and 33 pentobarbital patients. The success rate for the etomidate group was 57% at total doses of up to 0.3 mg/kg (n = 7) and 76% at total doses of up to 0.4 mg/kg (n = 17), in contrast to a success rate of 97% for pentobarbital at a total dose of up to 5 mg/kg (n = 33). The success rate for pentobarbital was significantly greater than the final etomidate group (P = 0.04; difference in proportions 20.5%, 95% Cl 1.9% to 44.4%). Patients receiving etomidate had significantly shorter induction times (P = 0.02; difference of means 2.1 minutes, 95% CI 0.35 to 3.86), sedation times (P < 0.001; difference of means 31.3 minutes, 95% Cl 24.0 to 38.5), and total examination times (P < 0.001; difference of means 53.1 minutes, 95% Cl 40.8 to 65.3). Significantly more parents in the etomidate group perceived their child to be back to baseline by discharge from the hospital (P < 0.001; difference of proportions 60.7, 95% CI 29.1 to 92.4) and expressed fewer concerns about their child's behavior after discharge (P = 0.024; difference of proportions 28.6, 95% CI 6.5 to 50.7). Conclusions: At the dosing used in this study, pentobarbital is superior to etomidate when comparing success rates for sedation. However, among the successful sedations, the duration of sedation was shorter in the etomidate group than in the pentobarbital group. Pentobarbital is associated with more frequent side effects and parental concerns compared to etomidate.
Sampling of Particulate Materials: Theory and Practice

(1984). Sampling of Particulate Materials: Theory and Practice. Technometrics: Vol. 26, No. 3, pp. 293-294.
Effect of Testosterone Propionate on Protein Synthesis by Two-Dimensional Electrophoresis in Rat Ventral Prostate

Two-dimensional polyacrylamide gel electrophoresis has been used to map the pattern of protein synthesis in rat ventral prostate from both castrate and testosterone treated animals. Proteins were detected by fluorography of 35S-methionine incorporation. In the soluble or cytosol fraction, four major proteins that have molecular weights less than 25,000 and isoelectric points (pi) less than 6.0 and one that has a molecular weight above 30,000 and pi 6.6 are under androgen control. One of these proteins with molecular weight 12,000 and pi 5.4 also appears in the microsomal fraction. Using nonequilibrium pH gradient electrophoresis, soluble proteins of pi greater than 7.0 were investigated. One major protein of 20-25,000 daltons and pi 8.0 appears to be androgen dependent. The ventral prostate from castrate synthesizes proteins which are not detectable in androgen stimulated castrates.
Pricing Term Insurance in the Presence of a Family History of Breast or Ovarian Cancer

Abstract We estimate the increased mortality and term life insurance costs for women who have a family history of breast or ovarian cancer. Using data from the medical literature on age-specific and family history-specific incidence rates, we develop double-decrement models to evaluate the actuarial impact of breast cancer and ovarian cancer in the family. We also calculate the increased mortality and term insurance costs for women who test positive for the BRCA1 or BRCA2 gene mutation. We find that the type of affected relative and her age at onset of the disease are key underwriting factors. We find substantial mortality increases (up to 100%) for women with two relatives with cancer and women with a first-degree relative who developed cancer at an early age. Mortality increases for women with the BRCA gene mutation reach 150%. While some females with a family history of cancer can be accepted at standard rates, others may need to be quoted substandard rates, depending on the underwriting policy of the ...
Interspecies mitochondrial fusion between mouse and human mitochondria is rapid and efficient.

A detailed molecular understanding of mitochondrial fusion and fission in mammalian cells is rapidly emerging. In this report, we demonstrate for the first time cross-species mitochondrial fusion between distantly related species using green and red fluorescent proteins targeted to the mitochondrial matrix. We found that mouse mitochondria were able to efficiently fuse to unmodified mitochondria of human cells and that the contents of the mitochondrial matrix were completely mixed in less than 4 h. We also observed that mitochondria from the mtDNA-less (ρ0) mouse cells can homogeneously fuse to the mitochondria of human cells. We were, however, unable to maintain human mitochondrial DNA in the mouse cells. These results indicate that mitochondrial fusion proteins in mouse and human cells have enough functional homology to mediate efficient cross-species mitochondrial fusion, but mouse nuclear and human mitochondrial genomes have not retained functional compatibility with one another.
Regulatory T-cells in type 1 diabetes.

Type 1 diabetes is a T-cell-mediated autoimmune disease, resulting in destruction of the insulin-producing beta cells in the pancreas. Disease progression is thought to involve the action of T-cells, particularly those producing Th1-type cytokines. Given the complexity in understanding the precise etiology of autoimmune diseases, the diversity of autoantigens, and the variability that exists between individual patients, it might be very difficult to eliminate autoaggressive T-cell responses without resorting to generalized means of immunosuppression. However, recent evidence shows that autoimmune processes are composed not only of autoaggressive T-cell responses but also of autoreactive regulatory components. Enhancing regulatory T-cell responses, therefore, has become an area of intense focus as a means of treating autoimmune diseases like type 1 diabetes. This review will concentrate on two different types of regulatory T-cells, the naturally occurring (‘professional’) CD4+CD25+ T-cells and antigen-induced (‘adaptive’) CD4+ Th2-like regulatory T-cells. Copyright © 2004 John Wiley & Sons, Ltd.
Business Ethics and Business Education: A Report from a Regional State University

My central point is that the recent wave of interest in business ethics is an opportunity to review the whole enterprise of undergraduate business education. Business ethics, taught as if the students, faculty, curriculum and organization of the business school were important parts of the subject matter, is a way both to affirm the seriousness of ethical inquiry and to build an increased sense of collegial responsibility for the overall curriculum students are asked to undertake.
BlueFinder: estimate where a beach photo was taken

This paper describes a system to estimate geographical locations for beach photos. We develop an iterative method that not only trains visual classifiers but also discovers geographical clusters for beach regions. The results show that it is possible to recognize different beaches using visual information with reasonable accuracy, and our system works 27 times better than random guess for the geographical localization task.
The critical effective size for a genetically secure population

For practical reasons, managers and policy-makers have to make rapid decisions with limited information on the status of endangered species. Because of its relative ease of acquisition, the most common surrogate used to derive inferences about the risk of extinction is population size. This is not to say that population size is the best indicator of risk; other considerations, such as the recent rate of population decline, are of clear importance (Mace & Lande, 1991). A popular rule of thumb for the critical population size necessary for the maintenance of adequate genetic variance for adaptive evolution in quantitative traits, originally espoused by Franklin (1980) and Soule (1980), has been an effective population size ( N e ) of 500 individuals. More recent assessments, based on both empirical and theoretical developments, suggest that this number should be revised upwards to N e ≃1000–5000 (Lande, 1995 a ; Lynch, 1995; National Research Council, 1995; Burger & Lynch, 1997). Here we address the arguments of Franklin & Frankham (1998) that a critical N e ≃500–1000 is adequate for conservation purposes.
A double-strand break in a herpesvirus genome stimulates targeted homologous recombination with exogenous, cloned viral sequences.

Abstract A method is described for the highly efficient recovery of recombinant pseudorabies virions; the approach should be applicable to other herpesviruses. Pseudorabies virus (PRV) strain PRV509 contains a unique Eco RI site in its genome, largely replacing the glycoprotein gC gene. By digesting PRV509 DNA with Eco RI prior to cotransfection with plasmid DNA that harbored a cloned copy of gC , we isolated recombinant viruses containing the cloned gC allele at a frequency exceeding 75%. This represented up to a 37-fold increase over the use of intact viral DNA in cotransfection experiments, and may eliminate the need for phenotypic screening of recombinants. Closer analysis of the recombinant viruses revealed that genetic markers up to 1 kilobase pair apart could be recombined into the genome using the Eco RI-digested DNA. Overall, the increased frequency of recombinant viruses can be explained if homologous recombination at sites of double-strand breakage is a more efficient repair mechanism than the re-annealing and ligation of the break itself.
"I Finally Got Real Parents, and Now They're Gonna Die"—A Case Study of an Adolescent With Two HIV-Positive Parents

Although several authors have addressed the matter of how children are affected when an adult caretaker has AIDS, most have focused on younger children, ages 3 to 10, rather than on adolescents. Even fewer authors have addressed the specific ways in which adolescents of different ethnic and socioeconomic groups respond to having a parent who is HIV-positive, or has developed full-blown AIDS. This case study examines the various therapeutic strategies used in working with the family of an adolescent Hispanic male street gang member whose mother was HIV positive, and whose father had already developed AIDS.
Shock analysis: Three useful new relations

The behavior of collisionless hydromagnetic shocks in interplanetary space is considered analytically, with a focus on relations, implicit in the governing Rankine-Hugoniot equations, involving the magnetic field (B) and the plasma velocity (V). A moving reference frame aligned with the shock is employed, and expressions are derived which make it possible (1) to determine the speed of a shock of arbitrary orientation from upstream and downstream measurements of B and V; (2) to characterize the change in flow direction as the plasma crosses the shock in terms of the plasma beta, the Mach number, and the angle between the upstream field and the shock normal; and (3) to infer the third component of the upstream-downstream velocity jump from B and two-dimensional V measurements. These expressions are applied to ISEE-3 data on an interplanetary shock on April 5, 1979, and the results are presented in tables.
Meningeal myeloma deposits adversely impact the therapeutic index of an oncolytic VSV

Vesicular stomatitis virus (VSV) is neuropathogenic in rodents but can be attenuated 50-fold by engineering the mouse interferon-beta (IFN-β) gene into its genome. Intravenously administered VSVs encoding IFN-β have potent activity against subcutaneous tumors in the 5TGM1 mouse myeloma model, without attendant neurotoxicity. However, when 5TGM1 tumor cells were seeded intravenously, virus-treated mice with advanced myeloma developed clinical signs suggestive of meningoencephalitis. Co-administration of a known active antimyeloma agent did not prolong survival, further suggesting that deaths were due to viral toxicity, not tumor burden. Histological analysis revealed that systemically administered 5TGM1 cells seed to the CNS, forming meningeal tumor deposits, and that VSV infects and destroys these tumors. Death is presumably a consequence of meningeal damage and/or direct transmission of virus to adjacent neural tissue. In light of these studies, extreme caution is warranted in clinical testing of attenuated VSVs, particularly in patients with CNS tumor deposits.
Algorithms for Fast Large Scale Data Mining Using Logistic Regression

This paper proposes two new efficient algorithms to train logistic regression classifiers using very large data sets. Our algorithms will lower the upper bound time complexity that the existing algorithm in the literature has and our experiments confirm that our proposed algorithms significantly improve the execution time. For our data sets, which come from Microsoft's Web logs, the execution time was reduced up to 353 times as compared to the algorithm often referenced in the literature. The improvement will be even greater for larger data sets
Oncogenes in melanoma.

Transformation of normal melanocytes into melanoma cells is accomplished by the activation of growth stimulatory pathways, typically leading to cellular proliferation, and the inactivation of apoptotic and tumor suppressor pathways. Small molecule inhibitors of proteins in the growth stimulatory pathways are under active investigation, and their application to melanoma patients would represent a new treatement strategy to inhibit cell proliferation or induce cell death. We provide a general overview of the mechanisms of oncogene activation and the functions of oncogenes. Lastly, we review oncogenic events in melanoma.
The dimensionality of black nationalism and African-American political participation

This article examines the dimensionality of black nationalism and its relationship to African-American political participation, focusing specifically on blacks' electoral and non-electoral involvem...
The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila.

The Sno oncogene (Snoo or dSno in Drosophila) is a highly conserved protein and a well-established antagonist of Transforming Growth Factor-β signaling in overexpression assays. However, analyses of Sno mutants in flies and mice have proven enigmatic in revealing developmental roles for Sno proteins. Thus, to identify developmental roles for dSno we first reconciled conflicting data on the lethality of dSno mutations. Then we conducted analyses of wing development in dSno loss of function genotypes. These studies revealed ectopic margin bristles and ectopic campaniform sensilla in the anterior compartment of the wing blade suggesting that dSno functions to antagonize Wingless (Wg) signaling. A subsequent series of gain of function analyses yielded the opposite phenotype (loss of bristles and sensilla) and further suggested that dSno antagonizes Wg signal transduction in target cells. To date Sno family proteins have not been reported to influence the Wg pathway during development in any species. Overall our data suggest that dSno functions as a tissue-specific component of the Wg signaling pathway with modest antagonistic activity under normal conditions but capable of blocking significant levels of extraneous Wg, a role that may be conserved in vertebrates.
Effect of 8-azaguanine on antibody synthesis in vitro.

CREASER1 has shown that 8-azaguanine is strongly inhibitory to induced enzyme formation in bacteria, but less so to the formation of ‘constitutive’ enzyme. On the basis of these findings and other evidence1, Creaser suggested that induced enzyme formation might be mediated by unstable ribonucleic acid templates needing continuous resynthesis, while ‘constitutive’ enzyme formation might utilize more stable templates.
Discharge correlations between neurons in the nucleus parabrachialis medialis during sleep-waking states

Summary Spontaneous activity from simultaneously recorded pairs of neurons in the nucleus parabrachialis medialis (NPBM) was examined in unanesthetized, unrestrained cats during each sleep-waking state. Functional interconnections between pairs of neurons were studied with cross-correlation techniques. A total of neuronal pairs were studied, 38 of which were recorded on separate, but proximal electrodes, and two pairs of which were recorded on the same electrode. Of the 40 pairs of neurons examined, 22 showed short delay (
Valence instabilities as a source of actinide system inconsistencies

The results of low-temperature physical property measurements made on the early actinide elements (U,Np and Pu) show a variability or inconsistency between test specimens. Anomalies appear especially in α-Pu, in transport phenomena such as electrical resistivity, thermoelectric power and Hall effect. Results have a surprisingly great dependence on impurity content and this may be a clue to the source of inconsistencies. The variability in physical property results for α-Pu, shown through publications of different experimentalists, has been previously surveyed by this author.1,2
Initial development of a questionnaire evaluating perceived benefits and barriers to pediatric clinical trials participation.

Abstract Objective To evaluate perceived benefits and barriers to pediatric clinical trials participation to improve decision-making and enhance recruitment and retention among minority youth with chronic health conditions (sickle cell disease, asthma) and their caregivers. Methods A questionnaire was developed based on the social ecological model using input from medical experts and community-based public health organizations. Parallel caregiver, adolescent/young adult (AYA; 16–39 years old), and child (8–15 years old) versions were field tested. Patients and caregivers completed the questionnaire, which included demographic items, perceived life stress and social desirability measures. Results Exploratory factor analysis rendered a four-factor solution for the caregiver version (direct treatment benefit, mistrust of research/researchers, trust in healthcare team to engage in safe research, and opportunity cost) and the AYA version (mistrust/no direct benefit, safety, direct treatment benefit/practical considerations, and social support for research). Factor structures differed for SCD and asthma caregivers; results were equivocal for the child version. Summated subscales were not significantly associated with patient demographics or social desirability, but significant correlations with perceived life stress and prior participation in research were identified. Conclusions While the factor structure should be confirmed with larger samples, findings indicate potential benefit, perceived harm due to mistrust of researchers, and logistics are primary factors in decision-making about participation in pediatric clinical trials. By addressing these benefits/barriers through adjustments to recruitment and informed consent procedures, researchers may address misperceptions of research, improve decision-making, and increase recruitment and retention particularly for ethnic minority children with chronic health conditions.
The effect of para-Chlorophenylalanine on the intake of ethanol and saccharin solutions

Abstract The effects of para-chlorophenylalaline (PCPA) on the ingestive behavior of rats offered a choice between ethanol (3%) and water, saccharin (0.125%) and water, or water alone were examined. Following a baseline period three saline or PCPA injections, 80 mg/kg, were administered. Decreases in both ethanol and saccharin intakes were observed. Increases in water intake occured in the ethanol group without a change in total fluid intake. Increases in water intake did not occur in the saccharin group and these animals displayed decreases in total fluid intake. Water intake in the nonchoice group was unaffected. There were no changes in food intake associated with any of these effects. The data demonstrate that decreases in intakes following PCPA are not specific to ethanol solutions.
Seeing the Forest Through the Trees: Some Renewed Thinking on Dispositions Specific to Social Studies Education

Too often, social studies educators are asked to focus their design and enactment of learning experiences on the mastery of content knowledge, often at the expense of other aims and goals. In response to this problem, the authors of this article explore the reclamation of dispositions in social studies curriculum planning and teaching. First, he authors clarify what is meant by dispositions in the social studies. Then, by drawing on seminal works in the field, they ofter a taxonomy of social studies dispositions in order to assist pre-service and in-service teachers to consciously plan for dispositional development. Finally, the authors detail how these dispositions can be operationlized within a series of practical examples.
Attachment Styles and Ethical Behavior: Their Relationship and Significance in the Marketplace.

This paper compares the ethical standards reported by consumers and managers with different attachment styles (secure, preoccupied, fearful, or dismissing). We conducted two studies of consumer ethical beliefs and a third managerial survey. In Study 1, we used a questionnaire that we constructed, and in Study 2, we used the Muncy–Vitell Consumer Ethics Scale. The results in both the studies were consistent and showed that men reported a greater indifference to ethical transgressions than women. Based on the two studies, the results indicate that␣among male consumers, the dismissing participants reported the greatest overall indifference to ethical transgressions and the secure participants expressed the most ethical beliefs. The two intermediate groups did not differ significantly from each other. In Study 1, none of the women consumers reported a dismissing attachment style. Women with a secure style reported more ethical beliefs than those in the other two groups. However, the sample in Study 2 included dismissing women. The dismissing women reported the greatest overall indifference to ethical transgressions and the secure women expressed the most ethical beliefs. The illegal profit subscale described the most severe ethical transgressions, and for both men and women, the secure participants were less apt than the other participants to report a willingness to transgress. In Study 3, the Newstrom and Ruch (1975, MSU Business Topics, Winter, 31) Questionnaire was administered to 227 managers. All four attachment patterns were represented among the participants of both genders. In all cases, the participants with a dismissing attachment style showed the greatest readiness to transgress.
Does Experience Matter for Patterns of Expansion by U.S. Companies in Latin America and the Caribbean

We describe expansion patterns by U.S. companies in Latin America and the Caribbean (LAC) between 1980 and 2005 using a unique sample that utilizes country, industry and time-series information on firms’ investments. We build on previous research to explore the effect of experience on firms’ preference for equity commitment. Using the time series properties of our data, we examine the extent to which previous investments in the region influence firms’ expansion patterns. Our analysis includes the traditional determinants of entry mode choices such as firm-specific factors, market seeking factors, resource seeking factors, and country specific factors. Bivariate probit results indicate that companies with previous experience in the region are more likely to commit equity going forward and this also holds for more recent companies with greater growth opportunities.
Psychologic Aspects of Galactorrhea

During their diagnostic examination 60 galactorrheic women were interviewed and given psychologic tests to explore their responses to galactorrhea in general as well as in association with differing prolactinemic states. Normoprolactinemic and hyperprolactinemic patients were compared with each other and with 24 nursing mothers. Reactions to the galactorrhea itself were often marked, and the discharge tended to revive adolescent conflicts. Psychologic reactions sometimes reinforced breast manipulation, possibly maintaining the galactorrhea. the incidence of depression and diminished libido among the hyperprolactinemic patients was significantly greater than among the normoprolactinemic patients or the nursing mothers. Psychologic management should include educational measures as well as helping the patient to separate fact from fantasy.
Emerging drugs for the treatment of cocaine use disorder: a review of neurobiological targets and pharmacotherapy

Introduction: Cocaine use is a global public health concern of significant magnitude, negatively impacting both the individual as well as larger society. Despite numerous trials, the discovery of an effective medication for treatment of cocaine use disorder remains elusive.Areas covered: This article reviews the emerging pharmacotherapies for treatment of cocaine use disorder, focusing on those medications that are currently in Phase II or III human clinical trials. Articles reviewed were obtained through searches of PubMed, Ovid MEDLINE, Clinicaltrials.gov and the Pharmaprojects database.Expert opinion: Research into cocaine pharmacotherapy must continue to show innovation. Given that medications targeting single neurotransmitter systems have demonstrated little efficacy in treatment of cocaine use disorder, the recent focus on pharmacotherapeutic agents with multiple neurobiochemical targets represents an exciting shift in trial design and approach. Additionally, consideration of pharmacogenetics may be...
The Relationship Between Independence and Judicial Review in Post‐Communist Courts

Following the collapse of communist rule in Central and Eastern Europe and the former Soviet Union, constitutional designers codified rules establishing independent judiciaries. To what degree do these constitutional and statutory guarantees of independence reflect the actual behavior of courts? Our analysis demonstrates that official judicial power does not predict expressions of judicial review—overturning legislation in whole or in part. Rather, exogenous factors, including economic conditions, executive power, identity of the litigants and legal issues, influence the likelihood that courts will nullify laws. Our findings should caution both scholars and institutional designers. Both formal and informal factors create the parameters in which courts operate. Although courts have become more powerful institutions in the post-communist era, they face a diverse set of constraints on independent action.
Towards a "4I" approach to personalized healthcare

Personalized healthcare holds the promise of ensuring that every patient receives optimal wellness promotion and clinical care based upon his or her unique and multi-factorial phenotype, informed by the most up-to-date and contextually relevant science. However, achieving this vision requires the management, analysis, and delivery of complex data, information, and knowledge. While there are well-established frameworks that serve to inform the pursuit of basic science, clinical, and translational research in support of the operationalization of the personalized healthcare paradigm, equivalent constructs that may enable biomedical informatics innovation and practice aligned with such objectives are noticeably sparse. In response to this gap in knowledge, we propose such a framework for the advancement of biomedical informatics in order to address the fundamental information needs of the personalized healthcare domain. This framework, which we refer to as a “4I” approach, emphasizes the pursuit of research and practice that is information-centric, integrative, interactive, and innovative.
Copper deficiency in UCu5−xSn [x = 0.37 (1)]

The ternary inter­metallic title compound, known hitherto as UCu5Sn (uranium penta­copper stannide), crystallizes with the hexa­gonal CeNi5Sn structure type, and it has been presumed to be a fully stoichiometric phase, devoid of any disorder. However, the present single-crystal X-ray diffraction studies at 120 K, carried out with crystals grown from an Sn flux, suggest the existence of a previously unnoticed phase width of the title compound UCu5−xSn. All the atoms occupy special positions: U (\overline{6}m2, \overline{3}m.), Sn (3m.) and Cu (.m., 3m., and two positions with \overline{6}m2).
Effect of separate sampling on classification accuracy

Motivation: Measurements are commonly taken from two phenotypes to build a classifier, where the number of data points from each class is predetermined, not random. In this ‘separate sampling’ scenario, the data cannot be used to estimate the class prior probabilities. Moreover, predetermined class sizes can severely degrade classifier performance, even for large samples. Results: We employ simulations using both synthetic and real data to show the detrimental effect of separate sampling on a variety of classification rules. We establish propositions related to the effect on the expected classifier error owing to a sampling ratio different from the population class ratio. From these we derive a sample-based minimax sampling ratio and provide an algorithm for approximating it from the data. We also extend to arbitrary distributions the classical population-based Anderson linear discriminant analysis minimax sampling ratio derived from the discriminant form of the Bayes classifier. Availability: All the codes for synthetic data and real data examples are written in MATLAB. A function called mmratio, whose output is an approximation of the minimax sampling ratio of a given dataset, is also written in MATLAB. All the codes are available at: http://gsp.tamu.edu/
Models and Metrics to Enable Energy-Efficiency Optimizations

Power consumption and energy efficiency are important factors in the initial design and day-to-day management of computer systems. Researchers and system designers need benchmarks that characterize energy efficiency to evaluate systems and identify promising new technologies. To predict the effects of new designs and configurations, they also need accurate methods of modeling power consumption.
Geomorphology and ecology: Unifying themes for complex systems in biogeomorphology

The interaction of geomorphic and ecologic landscape components has been largely conceptualized as independent. In one direction, geomorphic processes and landforms shape the distribution of biota. Conversely, in the other direction, biota modify geomorphic processes and landforms. Increasingly, the interactions between geomorphic and ecological components are more circular and developmentally intertwined. In this paper, I integrate these two independent perspectives within the framework of complexity theory. I outline four themes that characterize complex systems in biogeomorphology: multiple causality and the concept of recursivity, the influence of organisms that function as ecosystem engineers, the expression of an ecological topology, and ecological memory. Implicit in all of these themes is the recognition that biogeomorphic systems are open and path dependent. They may exhibit a range of assembly states, from self-reinforcing stability domains to more transient configurations of organisms and environment.
Systemic Hemophilus Influenzae Disease in Children A 10-Year Retrospective Study of an Urban Hospital Population

A 10-year retrospective study of age-frequency, sites of infection, and pre-existing conditions in 297 children with Hemophilus influenzae (HI) disease seen at Grady Memorial Hospital from 1974 through 1984 is described. The majority of the patients were black (73%) and of lower socio-economic status and were less than 2 years of age. Manifestations of HI disease were similar to those described in reports from other centers, with meningitis being the most common (56.7%). Epiglottitis was much less common in the present study than is generally reported. The death rate of all patients was 1.8 percent. The results of this study indicate that HI disease continues to be a significant risk in children less than 2 years of age.
Erosion and landscape development decouple strontium and sulfur in the transition to dominance by atmospheric inputs

Weathering and leaching can progressively deplete the pools of soluble, rock-derived elements in soils and ecosystems over millennial time-scales, such that productivity increasingly relies on inputs from atmospheric deposition. This transition has been explored using strontium isotopes, which have been widely assumed to be a proxy for the provenance of other rock-derived elements. We compared rock versus atmospheric proportions of strontium to those for sulfur, a plant macronutrient, at several tropical forest sites in Hawaii and Costa Rica. Isotopic analyses reveal that sulfur is often decoupled from strontium in the transition to atmospheric dependence. Decoupling is likely the result of differences in chemical factors such as atmospheric input rates, mobility in the soil environment, and mineral weathering susceptibility. Strontium and sulfur decoupling appears to be accentuated by the physical process of erosion. Erosion rates are presumed to be high on the Osa Peninsula of Costa Rica, where the recent onset of rapid tectonic uplift has placed the landscape in a transient state. Decoupling is strong there, as erosion has rejuvenated the supply of rock-derived strontium but not sulfur. The landscape response to changes in tectonic uplift on the Osa Peninsula has produced decoupling at the landscape scale. Decoupling is more variable along a Hawaiian catena, presumably due to smaller scale variations in erosion rates and their influence on rejuvenation of rock-strontium inputs. These results illustrate how chemical and physical processes can interact to produce contrasting origins for different nutrient elements in soils and the ecosystems they support.
Phosphorylation of human tau protein by microtubule-associated kinases: GSK3beta and cdk5 are key participants.

Microtubules (MTs), primarily composed of alpha and beta tubulin polymers, must often work in concert with microtubule-associated proteins (MAPs) in order to modulate their functional demands. In a mature brain neuron, one of the key MAPs that resides primarily in the axonal compartment is the tau protein. Tau, in the adult human brain, is a set of six protein isoforms, whose binding affinity to MTs can be modulated by phosphorylation. In addition to the role that phosphorylation of tau plays in the "normal" physiology of neurons, hyperphosphorylated tau is the primary component of the fibrillary pathology in Alzheimer's disease (AD). Although many protein kinases are known to phosphorylate tau in vitro, the in vivo players contributing to the hyperphosphorylation of tau remain elusive. The experiments in this study attempt to define which protein kinases and protein phosphatases reside in the associated network of microtubules, thereby being strategically positioned to influence the phosphorylation of tau. Microtubule fractions are utilized to determine which of the microtubule-associated kinases most readily impacts the phosphorylation of tau at "AD-like" sites. Results from this study indicate that PKA, CK1, GSK3beta, and cdk5 associate with microtubules. Among the MT-associated kinases, GSK3beta and cdk5 most readily contribute to the ATP-induced "AD-like" phosphorylation of tau.
Ventricular rate control in chronic atrial fibrillation during daily activity and programmed exercise: a crossover open-label study of five drug regimens

Abstract OBJECTIVES We compared the effects of five pharmacologic regimens on the circadian rhythm and exercise-induced changes of ventricular rate (VR) in patients with chronic atrial fibrillation (CAF). BACKGROUND Systematic comparison of standardized drug regimens on 24 h VR control in CAF have not been reported. METHODS In 12 patients (11 male, 69 ± 6 yr) with CAF, the effects on VR by 5 standardized daily regimens: 1) 0.25 mg digoxin, 2) 240 mg diltiazem-CD, 3) 50 mg atenolol, 4) 0.25 mg digoxin + 240 mg diltiazem-CD, and 5) 0.25 mg digoxin + 50 mg atenolol; were studied after 2 week treatment assigned in random order. The VR data were analyzed by ANOVA with repeated measures. The circadian phase differences were evaluated by cosinor analysis. RESULTS The 24-h mean (±SD) values of VR (bpm) were − digoxin: 78.9 ± 16.3, diltiazem: 80.0 ± 15.5, atenolol: 75.9 ± 11.7, digoxin + diltiazem: 67.3 ± 14.1 and digoxin + atenolol: 65.0 ± 9.4. Circadian patterns were significant in each treatment group (p CONCLUSIONS This study indicates that digoxin and diltiazem, as single agents at the doses tested, are least effective for controlling ventricular rate in atrial fibrillation during daily activity. Digoxin + atenolol produced the most effective rate control reflecting a synergistic effect on the AV node. The data provides a basis for testing the effects of chronic suppression of diurnal fluctuations of VR on left atrial and ventricular function in CAF.
Sterol/steroid metabolism and absorption in a generalist and specialist caterpillar: Effects of dietary sterol/steroid structure, mixture and ratio

Abstract Insects cannot synthesize sterols de novo , so they typically require a dietary source. Cholesterol is the dominant sterol in most insects, but because plants contain only small amounts of cholesterol, plant-feeding insects generate most of their cholesterol by metabolizing plant sterols. Plants almost always contain mixtures of different sterols, but some are not readily metabolized to cholesterol. Here we explore, in two separate experiments, how dietary phytosterols and phytosteroids, in different mixtures, ratios, and amounts, affect insect herbivore sterol/steroid metabolism and absorption; we use two caterpillars species – one a generalist ( Heliothis virescens ), the other a specialist ( Manduca sexta ). In our first experiment caterpillars were reared on two tobacco lines – one expressing a typical phystosterol profile, the other expressing high amounts/ratios of stanols and 3-ketosteroids. Caterpillars reared on the control tobacco contained mostly cholesterol, but those reared on the modified tobacco had reduced amounts of cholesterol, and lower total sterol/steroid body profiles. In our second experiment, caterpillars were reared on artificial diets containing known amounts of cholesterol, stigmasterol, cholestanol and/or cholestanone, either singly or in various combinations and ratios. Cholesterol and stigmasterol-reared moths were mostly cholesterol, while cholestanol-reared moths were mostly cholestanol. Moth tissue cholesterol concentration tended to decrease as the ratio of dietary cholestanol and/or cholestanone increased. In both moths cholestanone was metabolized into cholestanol and epicholestanol. Interestingly, M. sexta generated much more cholestanol than epicholestanol, while H. virescens did the opposite. Finally, total tissue steroid levels were significantly reduced in moths reared on diets containing very high levels of cholestanol. We discuss how dietary sterol/steroid structural differences are important with respect to sterol/steroid metabolism and uptake, including species-specific differences.