The relationship between African-American women's health discussion networks & HIV risk behaviors

s / Drug and Alcohol Dependence 156 (2015) e102–e182 e167 Methods: Healthy volunteers (18–50 yrs), stratified by CYP2D6 phenotype (extensive (EMs) vs poor (PMs)metabolizers) after an 8h debrisoquine urinary recovery ratio test, underwent five sessions inwhichMA (10 and15mg), caffeine (500mg), codeine (120mg) or placebo was administered in random order. Subjective and cardiovascular measures were obtained preand at 30, 60, 90, 120, 180, 240, 300 and 360min post-drug. For eachmeasure, AUCwas generated within each session. Data were entered separately for placebo and each drug into mixed models ANOVA with CYP2D6 phenotype and dose (e.g., placebo, MA10, MA15; placebo, caffeine; placebo, codeine) as factors. Results: Thus far, 5 EMs and 2 PMs at CYP2D6 have completed all sessions and 2 PM are actively participating. Preliminary AUC change fromplacebo data showed severalmain effects forMA, such thatMA at 15mg increased ratings of arousal (t=2.71, p<0.03) and vigor (t=2.33, p<0.05) on the POMS and systolic (t=2.30, p<0.05) and diastolic (t=2.86, p<0.02) blood pressure relative to placebo regardless ofmetabolizer status.MA-induced ratings of on theMBG subscale of the ARCI relative to placebo were significantly greater for EMs than PMs (t=2.92, p<0.02). No significant main effects or interactions have occurred with caffeine or codeine. Conclusions: These preliminary results suggest that MAinduced euphoric-like effects may differ depending on CYP2D6 phenotype. The lack of caffeineor codeine-induced main effects or interactions may be due to the doses not being high enough. Financial support: Supported by R21DA031837. http://dx.doi.org/10.1016/j.drugalcdep.2015.07.453 The relationship between African-American women’s health discussion networks & HIV risk behaviors Carrie B. Oser1, Kate Eddens1, Erin Pullen1, Brea Perry2, Richard Crosby1 1 Univ of Kentucky, Lexington, KY, United States 2 Indiana University, Bloomington, IN, United States Aims: HIV is an epidemic in the African American community, where personal relationships are salient and can influence health behaviors. Yet, there is limited research examining egocentric social networks and African American women’s HIV risk behaviors. This study examines the relationship between African American women’s health discussion networks (size, composition, strength, and function) and HIV risk behaviors. Methods: Using data from the Black Women in the Study of Epidemics (B-WISE, n=344), multivariate models investigated associations between characteristics of health discussion networks and two risk behaviors: a positive drug screen and unprotected vaginal sex. Results:Theaverageparticipantwas single, 35yearsold, and the number of health discussion networkmembers ranged from 0 to 5, with 22% having no one to talk to about their health (mean=1.39, S.D. = 1.10). African American women were less likely to use drugs when they reported larger (AOR= .71; 95% CI: .55–.92) or closer (AOR= .79; 95% CI: .68–.92) networks, as well as those comprised of people who provided a variety of support functions including instrumental (AOR= .52; 95% CI: .31–.88) or financial (AOR= .59; 95% CI: .34–.99) support, health information (AOR= .44; 95% CI: .25–.78), and discussing health (AOR= .51; 95% CI: .28–.90). In contrast, health discussion network variableswere not associatedwith unprotected sex. Conclusions: It is concerning that almost one-quarter ofwomen had no one to talk to about their health considering that larger, closer-knit, and more supportive networks are protective against drug use for African American women. Risky sexual behaviors are challenging to change, which is problematic as most new HIV infectionsamongAfricanAmericanwomenareacquiredviaheterosexual contact. Future research should examine the characteristics of African American women’s health discussion networks as predictors of drug treatment and include health discussion networks in HIV interventions. Financial support: This research is funded by NIDA (R01DA022967 and K02-DA35116, PI: Oser). http://dx.doi.org/10.1016/j.drugalcdep.2015.07.454 Drug use and injection practices in Tajikistan: Qualitative study in Kulob and Khorog David Otiashvili 1, Alisher Latypov2, Umedjon Ibragimov3, Irma Kirtadze1, William Zule4 1 Addiction Research Center, Alternative Georgia, Tbilisi, Georgia 2 Management Sciences for Health, Leadership, Management and Governance, Kiev, Ukraine 3 Laney Graduate School, Emory University, Atlanta, GA, United States 4 RTI International, Research Triangle Park, NC,