cssi/SciSciGPT-SciSciNet huggingface dataset:
A Piece-Wise Linear Model for Approximating LMP-Load Curve based on Critical Load Levels

In deregulated power markets, it is of high interest to have a mathematical representation of the LMP- Load curve for the purpose of various analytical studies such as probabilistic LMP analysis. However, LMP versus Load curve may present various linear and nonlinear patterns, and appears challenging to develop a simple and unified form of mathematical model to capture those patterns observed in the LMP-Load curve. Studies have shown that the LMP-Load curve presents change of patterns at Critical Load Levels (CLLs) where step changes of LMP occur. By utilizing the concept of CLLs, this paper proposes a method to divide a LMP-Load curve into segments, and employ linear curve-fitting to obtain a piece-wise linear model to represent the actual LMP-Load curve. Through accurately identified break points of the curve, the proposed method can very closely approximate the actual curve, which traditional curve fitting methods would fail to do. The method has been tested on a revised IEEE 118-bus system. The resulting piece-wise linear model has been verified to be an exceptionally accurate model to represent the actual LMP-Load curve. Various patterns of the curve have been captured and closely represented by the piece-wise linear approximation model.
"The Responsibility to Learn": an Investigation into the Language Ideologies of Young Women Speakers of Chinuk Wawa

Chinuk Wawa is a language indigenous to the Pacific Northwest of the United States. Despite its status as an endangered language, Chinuk Wawa is being actively revitalized and developing more speakers as the initiative continues. The purpose of this inquiry is to demonstrate the complexity of language ideologies held in the Chinuk Wawa revitalization community, in particular that of young women (18-30 years old), whose participation is vital to the revitalization effort. This study revealed several themes in the language ideology of these Chinuk Wawa users: identity, authenticity, and responsibility. Identifying these themes contributes to further understanding the language’s prospects and encourages further research on language ideology within the Chinuk Wawa community. Running head: YOUNG WOMEN SPEAKERS OF CHINUK WAWA 3
Polysomnography in Rett Syndrome

Respiratory patterns, awake and asleep, were investigated by polysomnography in 30 female patients with Rett syndrome and compared with 30 controls at the Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, and the Department of Neurology, Kennedy Krieger Institute, Baltimore, MD.
Technological change in US coal mining: issues and evidence

Evolution de 1974 a 1983 des depenses de R et D dans l'industrie charbonniere aux Etats-Unis. Evolution de 1960 a 1980 de la productivite de la main-d'œuvre dans les exploitations souterraines et les mines a ciel ouvert
A physical SiGe-base HBT model for circuit simulation and design

A physical compact model for the SiGe-base HBT is presented. The model, implemented in SPICE2, accounts for the carrier transport in the heterostructural base, including explicit dependences on nonuniform doping density as well as energy gap. The model is verified based on HBTs from an aggressive SiGe-base technology, and device and circuit simulations are discussed, giving insight regarding optimal design of the technology. >
Phase II Trial of WT1 Analog Peptide Vaccine in Patients with Acute Myeloid Leukemia (AML) in Complete Remission (CR)

Abstract 3624 WT1 is a transcription factor which has been implicated in leukemogenesis and has been used as a marker of minimal residual disease (MRD). We previously demonstrated the feasibility of vaccinating AML patients in CR with a multivalent WT1 peptide vaccine and inducing immune responses. In an effort to further explore the safety and efficacy of this approach, we are conducting a Phase II study in which the vaccine is administered to AML patients in first CR and who completed all planned postremission chemotherapy. Eligible patients had WT1 transcript detectable by RT-PCR. The vaccine consisted of 4 native and derived WT1 peptides administered with the immune adjuvants Montanide and GM-CSF. Patients received 6 vaccinations over 10 weeks. Early toxicity was assessed at weeks 2 and 4. Immune responses were evaluated at week 12 by CD4+ T cell proliferation, CD3+ T cell interferon-g interferon release (ELISPOT) and WT1 peptide tetramer staining. Patients who were clinically stable and without disease recurrence could continue with up to 6 more vaccinations administered approximately every month. To date, 12 patients have been accrued to the study (6-M, 6-F; median age – 66 years, range 26–73 years). Cytogenetic subtypes varied among the study patients (Favorable-3, Intermediate-5, Unfavorable-4). The median time to vaccination after achieving CR was 7.5 months (range: 3–22 months). One patient was removed early because of relapse prior to receiving the first vaccination. Four patients have received at least 6 vaccines and 2 others have completed 12 vaccinations. Eight patients are alive without evidence of disease. One of these patients has an HLA-A02 subtype and was found to have developed T cells reactive with WT1-A (native peptide) HLA tetramers following 6 vaccinations which persisted (at a lower level) until after the 12th vaccination. Three patients relapsed during vaccination (after 1, 5 and 11 vaccines) and 2 of the 3 have died. Two of the relapsed patients who had sample available for immunologic evaluation, did not develop a CD4+ response to any of the peptides tested. Two other patients discontinued vaccination because of toxicity (hypersensitivity/pain with GM-CSF administration). Both remain in CR. No episodes of anaphylaxis or generalized urticaria were observed. Neither median disease free survival nor overall survival has been reached in this small cohort of patients. These preliminary findings demonstrate that the WT1 peptide vaccine is relatively well tolerated and has immunologic activity. Trial accrual is ongoing and further follow-up is required before any beneficial effect on outcome can be determined. Disclosures: Scheinberg: Formula Pharma: WT1 Vaccine inventor, Patent held by MSKCC and Licensed to Formula Pharma, WT1 Vaccine inventor, Patent held by MSKCC and Licensed to Formula Pharma Patents & Royalties.
Optimal component sizing in a two-reservoir passive energy harvesting system

We utilize particle swarm optimization to reduce the size of the energy management components in an energy harvesting system, allowing us to eliminate the need for voltage regulators or DC-DC converters without affecting system performance. Prior literature on optimal power management in microelectronics [1, 2] has relied on engineering estimates or exhaustive parameter searches to optimize system design. No prior literature has considered the optimal design of a device with only passive components [3]. By using particle swarm optimization, we demonstrate a 55% reduction in device size relative to conventional engineering calculations of an optimal device design.
Designing Application Permission Models that Meet User Expectations

How should applications legitimately requiring access to sensitive resources to carry out their functionality be granted access to those resources? The answer to this question depends on users. This article introduces user-driven access control, an alternate permission model that adheres to the principle of least privilege while reducing the burden on users to make explicit permission decisions.
The Influences of Parent and Peer Attachment on Bullying

Individuals with secure attachments to parents and peers are less likely to be bullies and victims of bullying. The current study examined the interplay between gender, parent attachment, and peer attachment as factors related to roles (bullying involvement, defending a victim, and outsider) during bullying. One-hundred forty-eight adolescents (M age = 15.68) completed surveys about parent and peer attachment and roles during bullying. Findings indicated that females were less likely than males to be involved in bullying and were more likely than males to defend a victim or be an outsider (ps .05). However, this was only true for males (p < .01). These results indicate that having a secure attachment to peers may be a potential protective factor against bullying involvement for males with insecure attachments to parents. Future research should examine the possible mechanisms involved in the association between attachment and bullying, such as empathy, aggression, or social information processing.
Improving on-farm water use efficiency: Role of collective action in irrigation management

Abstract Do better performing water user associations improve on-farm water management? Using data from Pakistan, we find that better water user association performance in a community is associated with higher water use efficiency of member farmers. Mean on-farm water use efficiency is higher for farmers belonging to communities that more broadly participated in watercourse maintenance, voted to elect their representatives in upper-tier management, participated in water charge collection, and were involved in dispute resolution. While these results provide a sanguine view of the outcome of devolution of irrigation management for water management success, we argue that this may not be interpreted as impacts of water user association performance. Results suggest that underlying community characteristics and/or social interactions may be driving both the performance of water user associations and on-farm water use efficiency.
Agile and other trends in software engineering

Successfully developing and delivering multi-year, multi-person software projects remains a highly challenging task. Software engineering researchers have spent considerable energy investigating ways to improve this situation by developing various processes, techniques, and tools over the last five decades. Understanding trends in the current state of the practice is crucial to identifying the challenges that software engineers face today, the changes their organizations are tackling, and how these challenges and changes impact industrial software production. This paper reports survey results from 99 software engineering developers and managers regarding their choice of process, technique, and tools, as well as their impressions as to the contributing factors towards project success or failure. In particular, the paper includes a focus on trends in adoption of agile practices. The data reinforces some known challenge areas such as the need for more effective communication. It also shows that there is a clear trend towards agile adoption across organizations, albeit traditional processes are still firmly entrenched in some areas. Scrum is the most common agile process in use, but it often gets adapted differently by different organizations, each according to their need. On the other hand, extreme programming was found to be almost non-existent in practice. The data also reveals that inadequate or unclear requirements are still the major problem that dogs the software industry. Similarly, a lack of rigorous time and cost estimation is commonplace. Together these two alone may explain the staggeringly high rate of software failures and delays. Finally, tool usage in industry varies quite widely; but there are certain areas (such as version control and unit testing) witnessing almost universal tool adoption.
High Performance Communication on Reconfigurable Clusters

FPGA clusters with the FPGAs directly linked through their Multi-Gigabit Transceivers (MGT) have a proven advantage over other commodity architectures for communication-bound applications. To date, however, communication infrastructure for such clusters has generally taken one of two approaches: nearest neighbor only, which is fast but has limited utility, and processor-based, which is general, but relatively slow. What is needed is for communication microarchitecture of these systems to be systematically explored, as has been done for HPC clusters and for Networks on Chip (NoC) on both FPGAs and ASICs. Our first contribution is finding that the properties of clusters of tightly coupled FPGAs substantially influence the router design space. We create a candidate router and generalize it so that it is parameterized by routing algorithm, arbitration policy, and virtual channels (VC). We have created a cycle-accurate simulator validated on a four-FPGA system. We evaluate the design space with respect to a number of standard communication patterns and packet sizes. These results enable selection of the appropriate router for any resource budget. We find that the optimality of the router design varies significantly with workloads. We present a framework that helps to determine appropriate parameters based on different applications and generate the HDL design. We observe that for a 512 FPGA cluster, compared with the router configuration with the best average performance, application-aware router selection can lead to substantial improvement in performance or reduction in area.
Application-driven dynamic power management for self-powered vigilant monitoring

While body sensor networks (BSNs) have proven to be a feasible solution for long-term vigilant health monitoring, limited battery life remains one of the main factors that has impeded their widespread adoption. Energy harvesting technologies bring an opportunity to address this issue by enabling the development of self-powered BSNs. However, the dynamic nature of energy harvesting sources poses a challenge to self-powered vigilance. In this paper, an application-driven dynamic power management (DPM) method for self-powered BSNs is presented that optimally adapts system operation to energy availability while meeting application requirements for vigilant monitoring. Vigilant Atrial Fibrillation (AF) monitoring is investigated as an example case study, and a simulation using real-world energy harvesting profiles is executed to validate the model and the optimal solution.
Ergebnisse der Umfrage

Welche Methoden und Werkzeuge werden aktuell in Unternehmen eingesetzt, um die Prozessleistung zu uberwachen und die Entscheidungs‐ und Reaktionsfahigkeit in den Geschaftsprozessen zu erhohen? Und vor welchem Hintergrund geschieht dies? Diese Fragen standen im Mittelpunkt einer Online‐Befragung, die im Rahmen dieser Studie im Fruhjahr 2015 durchgefuhrt wurde.
Stability improvement of microgrids using a novel reduced UPFC structure via nonlinear optimal control

A reduced Unified Power Flow Controller (UPFC) structure is proposed to enhance transient stability of small-scale micro grids. The micro grid utilizes Photovoltaic (PV) unit as the Distributed Generation (DG) unit that is connected to the grid through dc-dc buck converter and inverter. The dc-dc converter provides a constant dc voltage at the output that is connected to the inverter. The inverter generates the proper ac voltage according to the system requirements to feed the gird. The reduced UPFC model exploits dc link of the DG unit to generate appropriate series voltage and inject it to the power line to enhance transient stability. It employs the nonlinear discrete-time Hamilton-Jacobi-Bellman (HJB) optimal control to ensure that the stability of the system is realized through minimum cost for the system. A Neural Network (NN) is used to approximate the cost function based on the weighted residual method. In order to verify efficiency of the proposed model and control scheme, the DG unit and proposed UPFC structure are tested in simulations and experiments. The results shows effective performance of the proposed approach in damping oscillations in the system.
The Riemann Mapping Theorem

In his Gottingen dissertation of 1851 Bernard Riemann enunciated (p. 40 of his Werke) and attempted to prove the famous theorem that now bears his name: Theorem 9.1 Every simply-connected region other than ℂ itself is conformal to an open disk.
High Temperature Reactions and Microstructures in the Al2O3-AlN System

The potential utilization of nitride and oxynitride ceramics in high and low temperature structural engineering systems has focused much interest on these materials. These new efforts have revealed many problems concerned with the formation, stability and sintering of single or multi-phase materials based on compositions in these systems. One of the keys to producing materials with controlled micro structures and optimized properties is an understanding of the phase equilibria. In particular, the phase diagram should include liquid and vapour phases if they occur.
The Role of Pseudomonas Aeruginosa in Community Acquired Pneumonia

Community-acquired pneumonia (CAP) affects 3 to 4 million patients annually in the United States, and accounts for > 600,000 hospitalizations (1,2). HoweverPseudomonas aeruginosais a rare cause of CAP, implicated in fewer than 2% of cases. The vast majority of cases are caused by Streptococcus pneumoniae Hemophilus influenzae, and atypical pathogens (Legionella sppMycoplasma pneumoniae and Chlamydia pneumoniae)(1,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20). Enteric gram-negative bacteria occur in 2-9% of CAP requiring hospitalization, but almost exclusively affect patients with comorbidities. SimilarlyP. aeruginosavirtually never causes CAP in young, previously healthy adults, but may cause CAP in patients with specific risk factors or significant underlying disease(s) (see Table I).
Approach Selection: Multiple Anterior Lumbar Interbody Fusion to Recreate Lumbar Lordosis Versus Pedicle Subtraction Osteotomy: When, Why, How?

Restoration of physiologic lumbar lordosis is a fundamental principle of spinal deformity surgery. Techniques using multilevel anterior lumbar interbody fusion or pedicle subtraction osteotomy (PSO) are described. Multilevel anterior lumbar interbody fusion provides a gradual multilevel correction and avoids the morbidity associated with PSO but necessitates familiarity with the anterior approach or an approach surgeon. PSO provides a large angular correction at a single level, requires only one approach, and allows for simultaneous multiplanar correction and open posterior decompression. This article provides guidance on the appropriate use of each technique for restoration of lumbar lordosis in patients with degenerative lumbar deformity.
Insulin Glargine Dose and Weight Changes in Underweight, Normal Weight, and Overweight Children Newly Diagnosed with Type 1 Diabetes Mellitus

Study objective Newly diagnosed pediatric patients with type 1 diabetes mellitus (T1D) can be underweight, overweight, or normal weight at presentation. Study objectives were to determine if, across weight categories, admission body weight (ABW)-based initial insulin glargine dosing resulted in similar fasting blood glucose responses on day of discharge, how initial ABW-based doses differed from doses at outpatient follow-up, and whether an ideal body weight (IBW) would provide a better estimate of body weight after discharge. Design Retrospective chart review. Setting Urban tertiary academic medical center. Patients Eighty-one pediatric patients newly diagnosed with T1D who started therapy with subcutaneous insulin glargine between October 2014 and October 2016; patients were categorized by weight using body mass index (BMI) percentiles (underweight, normal weight, or overweight/obese). Measurements and main results Data on patient parameters from hospitalization to outpatient physician follow-up were collected. The McLaren, Moore, and BMI IBW methods were used to calculate IBW for each patient; these IBWs were compared with weights at outpatient follow-up. Initial insulin glargine doses were similar among all weight groups: median (range) 0.299 (0.227-0.4), 0.297 (0.204-0.421), and 0.291 (0.194-0.394) units/kg/dose, respectively, for the underweight, normal weight, and overweight/obese groups. No significant differences in discharge fasting glucose level or insulin glargine dose change from admission to first outpatient follow-up visit were noted. Underweight patients gained significantly more weight within 60 days after discharge compared with normal and overweight/obese patients, (median 16.3% vs 7.7% and 5.7%, respectively; p=0.002), aligning closest with the McLaren IBW. ABW was the best estimate of weight at outpatient follow-up in the overweight/obese patient group. Conclusion For children who presented underweight, the McLaren IBW method was the best predictor of outpatient dose and body weight, whereas ABW was the best estimate in overweight and obese patients. Further investigation of the role of IBW- or ABW-based dosing methods in underweight pediatric patients with T1D may assist in optimal dosing.
Integrated X-Ray, NMR, ECD, and Computational Approaches to Assign the Stereochemistry of Nortriterpenoids:

Highly oxygenated nortriterpenoids are the principle bioactive chemical constituents isolated from plants of the genera Schisandra and Kadsura. The stereochemistry of these molecules remains a high...
Encapsulation of phycocyanin by electrospraying: A promising approach for the protection of sensitive compounds

Abstract Electrospraying consists of the generation of ultrafine particles through the application of an electric potential to a polymer solution under ambient temperature and pressure. Therefore, it can be used to encapsulate thermally sensitive compounds such as phycocyanin (PC), an important antioxidant. The aim of this work was to develop polymeric ultrafine particles for phycocyanin encapsulation through electrospraying. Ultrafine particles of polyvinyl alcohol (PVA) and PC with a mean diameter of 395 ± 71 nm were produced. Electrospraying resulted in high-efficiency phycocyanin encapsulation (75.1 ± 0.2%), proving to be an excellent method for coating this bioactive compound. In addition, the PC-PVA ultrafine particles showed thermal resistance to phycocyanin up to 216 °C and maintained their antioxidant activity. The results obtained in this work represent a relevant scientific contribution because they demonstrate the possibility, previously unreported in the literature, of using electrospraying as an alternative method to achieve phycocyanin encapsulation. In this way, high efficiency and reproducibility are obtained, and the bioactivity of the compound is maintained for possible future applications as a component in the formulation of novel foods.
Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners

A new Ni/Zr-mediated one-pot ketone synthesis is developed, with use of a mixture of (Me)3tpy·NiII- and py-(Me)imid·NiIICl2-catalysts. The NiI-catalyst selectively activates iodides, whereas the Ni...
Heterorhabditis bacteriophora Excreted-Secreted Products Enable Infection by Photorhabdus luminescens Through Suppression of the Imd Pathway

Upon entering the hemocoel of its insect host, the entomopathogenic nematode Heterorhabditis bacteriophora releases its symbiotic bacteria Photorhabdus luminescens, which is also a strong insect pathogen. P. luminescens is known to suppress the insect immune response independently following its release, but the nematode appears to enact its own immunosuppressive mechanisms during the earliest phases of an infection. H. bacteriophora was found to produce a unique set of excreted-secreted proteins in response to host hemolymph, and while basal secretions are immunogenic with regard to Diptericin expression through the Imd pathway, host-induced secretions suppress this expression to a level below that of controls in Drosophila melanogaster. This effect is consistent in adults, larvae, and isolated larval fat bodies, and the magnitude of suppression is dose-dependent. By reducing the expression of Diptericin, an antimicrobial peptide active against Gram-negative bacteria, the activated excreted-secreted products enable a more rapid propagation of P. luminescens that corresponds to more rapid host mortality. The identification and isolation of the specific proteins responsible for this suppression represents an exciting field of study with potential for enhancing the biocontrol of insect pests and treatment of diseases associated with excessive inflammation.
Full bandgap defect state characterization of β-Ga2O3 grown by metal organic chemical vapor deposition

The results of a detailed investigation of electrically active defects in metal-organic chemical vapor deposition (MOCVD)-grown β-Ga2O3 (010) epitaxial layers are described. A combination of deep level optical spectroscopy (DLOS), deep level transient (thermal) spectroscopy (DLTS), and admittance spectroscopy (AS) is used to quantitatively map the energy levels, cross sections, and concentrations of traps across the entire ∼4.8 eV bandgap. States are observed at EC-0.12 eV by AS; at EC-0.4 eV by DLTS; and at EC-1.2 eV, EC-2.0 eV, and EC-4.4 eV by DLOS. While each of these states have been reported for β-Ga2O3 grown by molecular-beam epitaxy (MBE) and edge-defined film fed grown (EFG), with the exception of the EC-0.4 eV trap, there is both a significantly different distribution in the concentration of these states and an overall ∼10× reduction in the total trap concentration. This reduction is consistent with the high mobility and low background compensating acceptor concentrations that have been reported for MOCVD-grown (010) β-Ga2O3. Here, it is observed that the EC-0.12 eV state dominates the overall trap concentration, in marked contrast with prior studies of EFG and MBE material where the state at EC-4.4 eV has dominated the trap spectrum. This sheds light on possible physical sources for this ubiquitous DLOS feature in β-Ga2O3. The substantial reduction in trap concentration for MOCVD material implies great promise for future high performance MOCVD-grown β-Ga2O3 devices.
“All In”: Poker as a Gendered Space

Manno situates poker as a culturally constructed sport and argues that the game is often a sexist, misogynist fantasy space where players are “all in” through the acceptance and displays of traditional masculinity. After providing a summary of expectations of the traditional male gender role, the chapter asserts that the poker table is a homosocial masculine space that transmits and polices values about traditional masculinity, often making it an unwelcome space for women. Focusing on the words of poker players and on depictions of poker in film and in advertising, Manno examines the gendered rhetoric of poker and how it reflects the values of the Poker Mindset.
Kaposi Sarcoma Inflammatory Cytokine Syndrome Presenting as Infection: A Case Report

Kaposi sarcoma inflammatory cytokine syndrome is a rare and fatal malignancy that is challenging to treat. The syndrome appears in individuals who are both human immunodeficiency virus and human herpesvirus 8 positive. The diagnosis of disease is challenging because its presentation mimics sepsis and it has a high mortality rate. A bone marrow biopsy is necessary for definitive diagnosis. This case report discusses a 40-year-old human immunodeficiency virus infection-positive African American male who presented to the emergency department with a chief complaint of left hallux pain in January 2018 after a trip to a nail salon in December 2017. Radiographic and magnetic resonance images suggested osteomyelitis of the distal phalanx, and Gram stain of bone showed gram-negative rods. The patient was started on antibiotic therapy for presumed osteomyelitis. As the patient's status deteriorated, a partial hallux amputation was then performed. Intraoperative specimens were negative for bacterial involvement, but pathology was positive for Kaposi sarcoma. During a 7-month progression, the patient's hematologic and overall status continued to decline. Despite diagnostic and treatment guidelines being followed, the patient died from this illness in July 2018. This case is interesting because of the atypical presentation of Kaposi sarcoma and highlights the rapid progression of the disease.
Systematic Review and Meta-Analysis of Management Strategies and Outcomes in Adult Spinal Neurocysticercosis.

Objective Spinal involvement in neurocysticercosis is rare and can lead to debilitating injury if not diagnosed and treated early. We aim to provide the reader with a thorough analysis of the best available evidence regarding patient characteristics, optimal treatment modality, and outcomes in cases of spinal neurocysticercosis. Methods A systematic review of the literature using PubMed, Google Scholar, and Web of Science electronic databases was made according to the PRISMA guidelines. An illustrative case of intramedullary–cervical spinal disease is also presented for illustrative purposes. Results A total of 46 reports of 103 patients fitting the screening criteria were identified. Isolated spinal involvement was seen in 46.15% of patients. Most infections (76.92%) had an intradural extramedullary localization, with 43.27% of cases involving >1 spinal cord level. The most common presenting symptoms were motor deficits (77.88%), pain syndromes (64.42%), and sensory deficits (53.85%). Combined surgical resection and pharmacologic therapy was the most frequently used treatment modality (49.04%) and had the highest proportion of patients reporting symptomatic improvement at follow-up (78.43%). Combination therapy had a significantly higher rate of neurologic recovery compared with surgery alone (P = 0.004) or medical treatment (P = 0.035). Conclusions Spinal involvement in neurocysticercosis should be considered in patients from or who traveled to endemic areas presenting with ring-enhancing lesions. Combined treatment with surgery followed by cysticidal and steroid medication seems to be superior to surgery or medical treatment in isolation and seems to provide the highest chances of recovery.
Severe Thrombocytopenia Associated With Black Seed Oil and Evening Primrose Oil.

We report the case of a 69-year-old female with stage IIIB endometrial adenocarcinoma who developed an acute thrombocytopenia with greater than 90% decrease from her baseline value in platelets one day after a laparoscopic hysterectomy. Subsequently, the patient was found to have bilateral subsegmental pulmonary emboli and a right atrial thrombus. The thrombocytopenia reached a nadir of 31,000/mL3 from a baseline of 410,000/mL3 and resolved without intervention. Prior to the surgery, the patient was taking black seed oil, which is commonly used for its anti-carcinogenic effects, and evening primrose oil daily for approximately one month. A literature review revealed that black seed oil contains thymoquinone, which is a compound related to quinine. Evening primrose oil is also known to reduce platelet aggregation and has anti-thrombotic properties. We believe the patient's thrombocytopenia was caused by a consumptive coagulopathy due to the formation of multiple thrombi and exacerbated by the use of herbal supplements, namely black seed and evening primrose oil.
A Comparative Analysis for Land Utilization：Steel and R/C Interlaced Structures

In architecture, interlace structural concept is considered as a new design approach for cosmopolitan cities with high density to minimize the land use and increase the interaction. With various architectural approach, land resources can be minimized by this interlace concept for residential complexes. Such buildings will eliminate the reduction of land resource problem and on the other side safety measures in structural design is incorporated by interlace concept of buildings. This new concept can be constructed steel or reinforced concrete. In this paper, an analytical approach has been presented for these buildings in architecture and structural design. In the research, design considerations were taken for interlaced structures with reinforced concrete and steel. Components of steel structure, isolated footing, and columns. This paper is presenting a step wise process for interlance structures. They are identification of project area, layout and model preparation, analysis and design of concrete interlaced structure, analysis and design of steel interlaced structure, drafting of the plans and costing and estimation of the structures. Comparison of both reinforced concrete and steel structures were carried out. The main aim of the paper is to provide a comparison between steel and concrete interlaced structure. A cost estimation was carried out to determine optimum design and construction for interlaced structures.
Antitrust and Ex-Ante Sector Regulation

Using ex-ante regulation to replace inefficient and ineffective ex-post litigation based antitrust is a familiar refrain for those interested in regulating large technology firms. But the narrative that antitrust is either solely or predominantly based on ex-post litigation is a false narrative, as both the current antitrust laws and its institutions incorporate many of the features that reformers put forth as ex-ante regulation. As a matter of optimal regulatory design, this is not surprising, as a true ex-ante approach will incorporate both approaches. In the U.S., the Supreme Court has expanded its implied immunity and related common law limits on the use of the antitrust laws in response to the potential costs of inconsistent and overlapping regulation. This forces an ex-ante choice between antitrust and sector specific regulation when addressing specific problems associated with regulated industries. We suggest the ex-ante choice between antitrust and sector regulation be made based on the comparative institutional advantage of each approach, and that such an approach will result in the allocation of duties to deal and price setting to sector specific regulators. Because both approaches are imperfect vehicles for controlling competition, both the initial allocation between antitrust and regulation and the choice to regulate in the first place should be undertaken with caution, and expected to involve a long, slow, and costly evolution towards a more efficient system of antitrust and regulation.
RNA sequencing-based analysis of the magnum tissues revealed the novel genes and biological pathways involved in the egg-white formation in the laying hen.

The mechanism of egg formation in the oviduct of laying hens is tightly controlled; each segment of the oviduct contributes a unique component of the egg. Several genes/proteins are involved in the synthesis of a completely healthy egg. This implies a time- and tissue-specific expression of genes and proteins in the different oviductal segments. We used hens at different physiological stages and time points to understand the transcriptional regulation of egg-white (albumen) synthesis and secretion onto the eggs in the magnum of laying hens. This study used Next-Generation Sequencing and quantitative real-time PCR (qPCR) to detect the novel genes and the cognate biological pathways that regulate the major events during the albumen formation. Magnum tissues collected from laying (n = 5 each at 3 h post-ovulation, p.o. and 15–20 h p.o.), non-laying (n = 4), and molting (n = 5) hens were used for differential gene expression analyses. A total of 540 genes (152 upregulated and 388 down-regulated) were differentially expressed at 3 h p.o. in the magnum of laying hens. Kyoto Encyclopedia of Genes and Genomes pathways analysis of the 152 upregulated genes revealed that glycine, serine, and threonine metabolism was the most-enriched biological pathway. Furthermore, the top two most enriched keywords for the upregulated genes were amino-acid biosynthesis and proteases. Nine candidate genes associated with albumen formation were validated with qPCR to have differential expression in laying, non-laying, and molting hens. Proteases such as TMPRSS9, CAPN2, MMP1, and MMP9 (protein maturation, ECM degradation, and angiogenesis); enzymes such as PSPH, PHGDH, and PSAT1 (amino-acid biosynthesis); RLN3, ACE, and REN (albumen synthesis, secretion and egg transport); and AVD, AvBD11, and GPX3 (antimicrobial and antioxidants) were recognized as essential molecules linked to albumen deposition in the magnum. This study revealed some novel genes that participate in the signaling pathways for egg-white synthesis and secretion along with some well-known functional genes. These findings help to understand the mechanisms involved in albumen biosynthesis.
Impediments and pressures to incorporate soft skills in Higher Education accounting studies

This study explores the impediments and the pressures to establish the policy of introducing skills and competencies in the Greek Higher Education (HE) accounting studies. Soft skills may improve c...
A Compositional Framework for Quantitative Online Monitoring over Continuous-Time Signals.

We investigate online monitoring algorithms over dense-time and continuous-time signals for properties written in metric temporal logic (MTL). We consider an abstract algebraic semantics based on complete lattices, which subsumes the Boolean (qualitative) semantics and the real-valued robustness (quantitative) semantics. Our semantics also extends to truth values that are partially ordered and allows the modeling of uncertainty in satisfaction. We propose a compositional approach for the construction of online monitors based on a class of infinite-state deterministic signal transducers that (1) are allowed to produce the output signal with some bounded delay relative to the input signal, and (2) do not introduce unbounded variability in the output signal. A key ingredient of our monitoring framework is a novel efficient algorithm for sliding-window aggregation over dense-time signals.
Modulation of Adipose Conversion of BALB/c 3T3 Cells by Tumor Promoters

The conversion of BALB/c 3T3 preadipose cells to mature adipocytes is inhibited by the tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA). The pH of the culture medium has a strong influence on the regulation of conversion. The inhibitory effect of TPA is dependent on the ability of the promoter to stimulate glycolysis under conditions in which the lactate produced can lower the pH of the culture medium. Thus, the mechanism by which TPA inhibits the adipose conversion of these cells appears to be stimulation of hexose transport activity and lactate production which creates an environment unfavorable for triglyceride synthesis and differentiation.
Roles of Reversible and Irreversible Aggregation in Sugar Processing.

Colloids (1-1000-nm particles) in sugarcane/beet juice originate from non-sucrose impurities (polyphenolic colorants, residual soil, polysaccharides) of the plant materials; additional colloids form during the high temperature processing. Colloids are reactive toward aggregation, sorption, desorption, and redox/hydrolysis/thermal transformation reactions. Both Derjaguin-Landau-Verwey-Overbeek (DLVO; van der Waals and electrostatic forces) and non-DLVO (involving hydrophilic colloids) interactions control the stability of colloids in juice. Heteroaggregation causes a range of feedstock and end product problems, including turbidity, viscosity, color, gelling, crystallization, starch ghost, and heat transfer problems. Even after intensive clarification and refining, trace colloidal impurities on white (refined) sugar remain to cause a problem known as acid beverage floc. Acid beverage floc is an example of DLVO-type aggregation of oppositely charged particles at decreased pH. Examples of irreversible aggregates include starch ghost and recalcitrant organomineral composites formed at elevated temperature that resist heat transfer. Fundamental knowledge in aggregation kinetics is necessary to predict the occurrence of undesirable aggregates, as pH, ionic strength, temperature, and sucrose concentration change during the processing of sugarcane/beet juice.
Acid mucopolysaccharide synthesis by chick amnion cell cultures: Inhibition by 5-Bromodeoxyuridine

Summary Cell lines derived fromthe chick amnion synthesize sulfated and unsulfated acid mucopolysacchardies in vitro. Polysaccharide formation was studied by viscometry of culture medium and by incorporation of labeled glucose and sulfate. Synthesis and deposition of polysaccharides depend upon the age of the cultures during the subculture period. Sparce cultures release most of the AMPS into the fluid phase of the culture medium giving rise to high medium viscosity. As the cultures become dense, more of the AMPS is retained near the cells and forms a metachromatic matrix between cells and medium. In addition, incorporation of labeled glucose into polysaccharide is 10-fold greater in cells from sparse cultures compared with dense cultures. These cyclic alterations in cellular activity are repeated during each subculture period for many months. Incorporation of 5-bromodeoxyuridine into DNa is accompanied by alterations in cell morphology and suppression of polysaccharide synthesis within 1–2 days. These effects can be prevented by simultaneous addition of thymidine. Cells grown in BUdR continue to proliferate and can resume normal activity when removed from the analogue and allowed to divide in untreated medium.
Time Budget Pressure and Filtering of Time Practices in Internal Auditing

Unlike external auditing, to date, no study has been done to determine the internal auditors′ dysfunctional behaviour under time budget pressure. Consequently, determines the attitude of internal auditors towards time budgets, and the likely or perceived existence of time filtering practices in internal auditing. Presents survey results which indicate that a majority of respondents perceived time budgets as an interference with the proper conduct of the audit and conceded to a natural conflict between the essence of time budgets and the gathering of sufficient and competent evidence. The survey results further indicated the filtering of time to be a relatively widespread phenomenon in all areas of internal auditing.
Robust global supply network design

It has been widely documented that disruptions and changes in the environment of manufacturing in a global enterprise impact the performance of the enabling supply network. The need exists for a methodology that can not only provide an objective and transparent evaluation of the efficiency and risks of a supply network configuration but that can also design supply network configurations with provably superior performance. Supply chain engineering SCE fundamentally applies the perspective and methodology of systems engineering to the domain of supply chains. SCE is the integrator of various corporate functions such as purchasing, production, distribution, and sustainment over the total product life cycle from design, through deployment, production, sustainment, and disposal. A supply chain is actually a network that consists of a diverse set of organizational and geographical components that typically change over time. The systematic design and management of such an inherently complex system requires the principles and tools of model-based systems engineering. A comprehensive and integrated model of the structure and the behavior of the supply network of a manufacturing enterprise has been developed. In this model the inherent uncertainty of the future environmental conditions in which the supply network will have to function is captured in a large number of scenarios. The variability of the profits achieved by the supply network for the various scenarios is used as a proxy for the supply network risk. The model allows for the explicit tradeoff of the systems life cycle profit with the variability of this profit. An efficient solution algorithm eliminates the vast majority of feasible supply network configurations from consideration and identifies all the Pareto-optimal configurations. However, the final selection of the network configuration depends on the risk preferences of the designer and the complexity of the enterprise. Selecting the supply network configuration with the appropriate robustness becomes one of the principal risk mitigation policies for the network and, in turn, the enterprise. The combination of the socio designer risk preferences and analysis and technical Pareto-optimization of all feasible supply network configurations creates a transparent engineering design process that finds the supply network configuration best matched to the objectives of the manufacturing enterprise.
Chapter 7 Electronic and structural response of materials to fast, intense laser pulses

Publisher Summary This chapter focuses on several theoretical and experimental studies of the response of matter to light with an emphasis on semiconductors and fast-intense laser pulses. This method is called “tight-binding electron–ion dynamics” (TED), because it permits simulations of the coupled dynamics of valence electrons and ion cores in a molecule or material and it employs a tight-binding representation for the electronic states. It is applicable to general non-adiabatic processes including interactions with an intense radiation field. TED is a technique for simulating the coupled dynamics of valence electrons and ion cores in a molecule or material. One of the great strengths of TED is that the structural response is treated at the same time as the electronic response. TED is a promising approach for biological molecules and complex materials because it is inherently an O(N) method. The chapter presents the results for various interesting phenomena involving the response of H 2 + to fast-intense laser pulses for the absorption and dichroism of chlorophyll and for a conformational change in butadiene.
The Israel-Palestine Conflict: One Hundred Years of War

Now entering its third edition, James L. Gelvin's award-winning account of the conflict between Israelis and their forebears, on the one hand, and Palestinians and theirs, on the other, offers a compelling, accessible and current introduction for students and general readers. Newly updated to take into account the effects of the 2010–11 Arab uprisings on the conflict and the recognition of Palestinian statehood by the United Nations, the book traces the struggle from the emergence of nationalism among the Jews of Europe and the Arab inhabitants of Ottoman Palestine through the present, exploring the external pressures and internal logic that have propelled it. Placing events in Palestine within the framework of global history, The Israel-Palestine Conflict: One Hundred Years of War skilfully interweaves biographical sketches, eyewitness accounts, poetry, fiction, and official documentation into its narrative.
Skeletal muscle fiber characteristics of world class shot-putters

Abstract Muscle samples were obtained from the gastrocnemius muscles of eight untrained males and eight world class shot-putters with a mean best performance of 19.77 meters (range 19.14 to 20.33 m). Fiber composition and mean cross-sectional areas were determined from muscle sections incubated for myosin adenosine triphosphatase and alpha-glycerophosphate dehydrogenase activity. Portions of the specimen were analyzed for total phosphorylase, lactate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase activities. The shot-putters displayed a wide range of muscle fiber compositions (13.0 to 67.0% slow twitch-ST) with a mean distribution of 37.8% ST fibers. Although they displayed a greater mean percentage of fast twitch (FT) fibers, their mean distribution was not significantly different (p < .05) from that of the untrained men (46.7% ST). The individual muscle fibers of the shot-putters were 35% larger than those of the untrained, while both groups had ST/FT mean fiber area ratios of 1.0. The...