cssi/SciSciGPT-SciSciNet huggingface dataset:
Understanding the Negative Effects of Legal Education on Law Students: A Longitudinal Test and Extension of Self-Determination Theory

Longitudinal studies suggest that law school has a corrosive effect upon the well-being (Benjamin, et al. 1986; Sheldon & Krieger, 2004) and values and motivation (Sheldon & Krieger, 2004) of students, ostensibly because of its problematic institutional culture (McKinney, 2002; Schuwerk, 2004). In a three year study of two different law schools, we applied self-determination theory's dynamic process model of thriving (SDT; Deci & Ryan, 2000) to explain such findings. Students at both schools declined in psychological need satisfaction and well-being over the three years. However, student reports of greater perceived autonomy support by faculty predicted less radical declines in need satisfaction, which in turn predicted better well-being in the third year, and also a higher GPA, better bar exam results, and more self-determined motivation for the first job after graduation. Institution-level analyses showed that although students at both schools suffered, one school was more controlling than the other, predicting greater difficulties for its students in terms of well-being, job motivation and bar passage. Implications for SDT and for legal education are discussed.
A PCR-based strategy to generate integrative targeting alleles with large regions of homology

Cryptococcus neoformans is an opportunistic fungal pathogen with a defined sexual cycle for which genetic and molecular techniques are well developed. The entire genome sequence of one C. neoformans strain is nearing completion. The efficient use of this sequence is dependent upon the development of methods to perform more rapid genetic analysis including gene-disruption techniques. A modified PCR overlap technique to generate targeting constructs for gene disruption that contain large regions of gene homology is described. This technique was used to disrupt or delete more than a dozen genes with efficiencies comparable to those previously reported using cloning technology to generate targeting constructs. Moreover, it is shown that disruptions can be made using this technique in a variety of strain backgrounds, including the pathogenic serotype A isolate H99 and recently characterized stable diploid strains. In combination with the availability of the complete genomic sequence, this gene-disruption technique should pave the way for higher throughput genetic analysis of this important pathogenic fungus.
Play-back buffers in networked control systems: Evaluation and design

The networked environment presents many new challenges for the design of feedback control systems. A specific problem is that networked control systems (NCSs) are subject to the performance-degrading effects of time-varying, random loop delays. Model predictive controllers are a well-known method for delay compensation, but often exhibit poor performance under these types of loop delay. This paper investigates the use of play-back buffers to remove the uncertainty in the delay. First we study the value of removing all delay uncertainty with comparisons to unbuffered PID control using a bounded- interval delay distribution, and then we explore optimal playback buffer design for bounded-interval and heavy-tailed delay distributions.
Utilization of medical resources in persons with DSM-III personality disorders in a community sample.

A community survey of 401 randomly selected subjects yielded 249 responders, of which twenty-six had DSM-III criteria personality disorders (PDs), and 167 had no personality disorder traits (controls). More PDs than controls were medically hospitalized during the last year (38% vs 17%, p = .006). A number of significant associations was found between the number of DSM-III personality trait questions answered in a positive fashion and medical utilization. These associations varied by gender. Most striking was the .50 correlation for females between flamboyant personality disorder scores and visits to the family doctor for mental health reasons.
Demystifying Online Genetic Databases

There has been an explosion of genetic information and keeping current can be difficult. Traditional methods for obtaining information may be obsolete. Many sources for genetic information are now found on the internet although they may be confusing to navigate and interpret. The purpose of this presentation is to outline commonly used genetic databases, and demonstrate how they may be accessed and used to interpret genetic data. The mission of the National Center for Biotechnology Information (NCBI), a resource for molecular biology information, is to develop new information technologies to support understanding of molecular and genetic processes related to health and disease. NCBI services include PubMed, Nucleotide, and the BLAST algorithm for sequence comparison. In this presentation, several genetic databases will be explored. Each database will be defined, the available genetic information described, database access demonstrated, and website information displayed. This presentation will provide education related to several genetic databases as a means of facilitating and promoting access to this information by a larger audience of nurses and health care providers involved with genetic health care.
Text Readability Level and Developmental Differences in Context Effects

Vocalization latency of target words which were either congruous or in- congruous with a story context was measured. The readability level of the story con- texts was varied. Third and sixth grade children each read stories which were of grade- appropriate level as well as stories with readability levels which were above their present grade level. The effect of story context on mean vocalization latency was greater for the third as compared to the sixth graders when grade-appropriate level stories were presented. However, these developmental differences in context effects were reduced when more difficult readability level stories were presented. The present study investigates the effects of extended and varied context readabili- ty levels on children's word naming latency- Recent findings have indicated that younger readers use context during word recognition to at least the same if not to an even greater extent than do older readers (Schvaneveldt, Ackerman, & Semlear, 1977; Schwantes, 1981a; West & Stanovich, 1978). The finding of this developmental context effect is compatible with various models which emphasize reading development as in- volving increased proficiency at automatic word feature processing (e.g., LaBerge & Samuels, 1974) and/or interactive-compensatory processing betweeen concept and data driven operations (Stanovich, 1980). The boundary conditions of this type of finding are important to understanding the processes underlying the development of the rela- tionship between contextual and graphic information during word recognition. The purpose of the present study is to investigate the generality of the developmen- tal context effect under conditions in which children read material with a greater degree of ecological validity. In most prior work in this area the same level of reading material has been presented to every age group being examined in the study. The stimulus materials used typically have been constructed so as to be appropriate to the grade level of the youngest age group under investigation. There are many methodological ad- The author wishes to acknowledge the assistance of Chrystal Hale and Cheryl Barwig in data collection. Re- quests for reprints should be sent to the above address.
Effect of normalization on microarray-based classification

When using cDNA microarrays, normalization to correct biases is a common preliminary step before carrying out any data analysis, its objective being to reduce the systematic variations between the arrays. The biases are due to various systematic factors - scanner setting, amount of mRNA in the sample pool, and dye response characteristics between the channels. Since expression-based phenotype classification is a major use of microarrays, it is important to evaluate microarray normalization procedures relative to classification. Using a model-based approach, we model the systemic-error process to generate synthetic gene-expression values with known ground truth. Three normalization methods and three classification rules are then considered. Our simulation shows that normalization can have a significant benefit for classification under difficult experimental conditions.
Protocol validation in complex systems

Protocol validation and verification techniques have been applied successfully for a number of years to a wide range of protocols. The increasing complexity of our communications systems requires us to examine existing techniques and make a realistic assessment of which techniques will be applicable to the complex systems of the future. We believe that validation techniques based on an exhaustive reachability analysis will not be effective. Sampling techniques, such as executing a random walk through the reachable state space, are effective in complex systems, since most protocol errors occur in many different states of the system.More than 10 years have elapsed since the first automated validation techniques were first applied to communications protocols [1,2]. In the meantime, considerable advances have been made in validation technology, but more significantly, the scale and nature of the validation problem have changed. The communications systems that we need to validate today are significantly more complex than those of ten years ago. Our methods must evolve in order to address the current challenge.This paper is concerned primarily with the nature of the validation process, and the results that we might reasonably expect to achieve when validating protocols in complex communications systems.
Detecting solar-induced chlorophyll fluorescence from field radiance spectra based on the Fraunhofer line principle

It is difficult to quantify the amount of chlorophyll fluorescence emitted by a leaf or canopy under natural sunlight because the reflected light obscures the fluorescence signal. In this study, two diurnal experiments were conducted on winter wheat (Triticum aestivum L.) and Japan Creeper (Parthenocissus tricuspidata) to detect the solar-induced chlorophyll fluorescence from field radiance spectra. In the separation of the fluorescence emissive signal from canopy radiance spectrum based on Fraunhofer lines, two Fraunhofer lines of the terrestrial oxygen absorption at 688 and 760 nm were observed in the radiance spectra by an Analytical Spectral Devices FieldSpec Pro NIR spectrometer, which largely overlaps the chlorophyll fluorescence emission spectrum of leaves. Therefore, Fraunhofer lines at 688 and 760 nm were selected to detect the emissive fluorescence. The diurnal changes of chlorophyll fluorescence in the two experiments were primarily affected by the diurnal changes of photosynthetically available radiation (PAR). The correlation coefficients (R/sup 2/) were greater than 0.9 for all the relationships between PAR and the solar-induced fluorescence of winter wheat and Japan Creeper at 688 and 760 nm based on Fraunhofer line-depth (FLD), suggesting that the solar-induced fluorescence could closely track the changes of PAR and chlorophyll fluorescence. The relative solar-induced fluorescence based on FLD was negatively related to Fv/Fm measured by an OS1-FL modulated chlorophyll fluorometer. The correlation coefficients (R/sup 2/) were 0.97 at 688 nm and 0.99 at 760 nm for winter wheat, and 0.79 at 688 nm and 0.78 at 760 nm for Japan Creeper. These results demonstrate that the solar-induced fluorescence from plant canopies can be detected from field radiance spectra based on the Fraunhofer line principle.
Multi-face radar processing: A new application of MIMO radar

Radar systems that utilize multiple phased arrays to obtain 360° coverage suffer from reduced sensitivity off-boresite from the phased array faces (aka “scan loss”). Multiface radar processing is a MIMO radar technique that takes advantage of the overlapping coverage from adjacent phased array faces to provide up to 5 dB more sensitivity, compensating for the scan loss that would otherwise be incurred.
Antialiasing Procedural Shaders with Reduction Maps

Both texture maps and procedural shaders surfer from rendering artifacts during minification. Unlike texture maps, there exist no good automatic method to antialias procedural shaders. Given a procedural shader for a surface, we present a method that automatically creates an antialiased version of the procedural shader. The new procedural shader maintains the original shader's details but reduces artifacts (aliasing or noise) due to minification. This new algorithm creates a pyramid similar to a MIP-Map in order to represent the shader. Instead of storing per-texel color, pyramid stores weighted sums of reflectance functions, allowing a wider range of effects to be antialiased. The stored reflectance functions are automatically selected based on an analysis of the different reflectances found over the surface. When the rendered surface is viewed at close range, the original shader is used, but as the texture footprint grows, the algorithm gradually replaces the shader's result with an antialiased one.
REACTION BETWEEN RHEUMATOID SERA AND ERYTHROCYTES SENSITIZED WITH GUINEA PIG ANTIBODY.

SummaryAntisera were obtained from guinea pigs by immunization with sheep erythrocytes. Sheep erythrocytes sensitized by subagglutinating amounts of such antisera were agglutinated by sera of patients suffering from rheumatoid arthritis. Four-hundred and twenty-eight human sera were used for comparison of results obtained with this test and the traditional test using rabbit antiserum for sensitization of sheep erythrocytes. A good agreement was observed. This, however, was the case only at relatively strong sensitization of the sheep erythrocytes. At weaker sensitization the test with rabbit antiserum was considerably more sensitive than the test with guinea pig antiserum.
Evaluating Field-Based Experiences in Teacher Education

Contemporary descriptions of the uses and abuses of field experiences in the preservice education of teachers abound. These are found in historical documentations of the role of student teaching and field experiences in teacher education (Mead, 1930; Curtis & Andrews, 1954; Stratemeyer & Lindsey, 1958; and Andrews, 1964) and from resources cited in the current literature. A recent Educational Resources Information Center (ERIC) search (Zimpher, 1987) generated 1,852 entries from 1966 to the present from the combined categories of “student teaching” and “field experiences.” A series of “state of the art” reviews of field experiences and student teaching also informs our understanding of both the nature of these experiences and of how teacher educators have studied these experiences. A review of these analyses provides a brief overview of issues and concerns related to field experience. This chapter offers recommendations regarding the organization and offering of programs of field experience in teacher education and a model for designing appropriate evaluation mechanisms for field experiences appropriate to the Center for Teacher Education Evaluation’s Accreditation Plus Model.
Cyclic 3',5'-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells

We studied cyclic 3',5'-nucleotide phosphodiesterase (PDE) isozymes and their role in adenosine 3',5'-cyclic monophosphate (cAMP) and cGMP metabolism in a rat inner medullary collecting duct (IMCD) cell line. The homogenized and fractionated IMCD cells of cAMP-PDE and all of cGMP-PDE activity were found in the cytosol. The majority of cytosolic cAMP-PDE (greater than 50%) was isozyme PDE-IV; the Ca(2+)-calmodulin-sensitive PDE-I was present only in cytosol. Preincubation of IMCD cells with PDE-IV inhibitor rolipram markedly (5x) enhanced levels of cAMP both basal and in the presence of [Arg8]vasopressin (AVP). Cilostamide (for PDE-III) or vinpocetine had no effect, whereas PDE-I inhibitor 8-methoxymethyl-3-isobutyl-1-methylxanthine (8-MeoM-IBMX) enhanced AVP-dependent cAMP levels. Exposure of IMCD cells to 2 microM ionomycin decreased both basal and AVP-stimulated cAMP. Depletion of Ca2+ by preincubation of IMCD cells in the Ca(2+)-free medium with ethylene glycol-bis (beta-aminoethyl ether)-N,N,N',N'-tet...
Immunotherapy of Advanced Malignancy by Direct Gene Transfer of an Interleukin-2 DNA/DMRIE/DOPE Lipid Complex: Phase I/II Experience

PURPOSE: We have completed a phase I study, followed by three phase I/II studies, in patients with metastatic melanoma, renal cell carcinoma (RCC), and sarcoma in order to evaluate the safety, toxicity, and antitumor activity of Leuvectin (Vical Inc, San Diego, CA), a gene transfer product containing a plasmid encoding human interleukin (IL)-2 formulated with the cationic lipid 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE) and administered intratumorally. PATIENTS AND METHODS: Twenty-four patients were treated in the phase I study. Leuvectin doses were 10 μg, 30 μg, or 300 μg weekly for 6 weeks. In three subsequent phase I/II studies, a total of 52 patients (18 with melanoma, 17 with RCC, and 17 with sarcoma) were treated with further escalating doses of Leuvectin: 300 μg twice a week for 3 weeks, 750 μg weekly for 6 weeks, and 1,500 μg weekly for 6 weeks. RESULTS: There were no drug-related grade 4 toxicities and only one grade 3 toxicity,...
Charakterisierung, Ursprung und Einteilung der Vertebraten

Was ist ein Vertebrat und wie sind Vertebraten entstanden? Wenige Tiergruppen koonnen durch ein oder zwei bestimmte Merkmale charakterisiert werden. So ist ein Tier mit einem Gabelbein (Furcula) und Federn ein Vogel. Ein Tier mit Milchdrusen ist ein Saugetier. Entsprechend ist ein Tier mit einem Cranium, also einer skelettartigen Schadelkapsel, ein Vertebrat. Will man allerdings die Struktur des ganzen Korpers verstehen und interpretieren, ist es hilfreich, die Kombination vieler Merkmale fur die Beschreibung eines Vertebraten zu benutzen. Dafur wahlt man nicht nur Merkmale aus, die fur die Gruppe einzigartig sind, sondern auch solche, welche die Vertebraten unter verwandten Gruppen einordnen.
Experimental and Calculated Electrochemical Potentials of Common Organic Molecules for Applications to Single-Electron Redox Chemistry

Herein, we report half-peak potentials for over 180 organic substrates obtained via cyclic voltammetry. These values are of great use in assessing the thermodynamics of an electron-transfer process. In addition, we disclose a simple computational method to determine redox potentials of organic substrates.
Abstract 393: Perioperative Cardiovascular Events and Long-Term Mortality Following Orthopedic Surgery

Background: Adverse cardiovascular events are a major cause of morbidity and mortality in the perioperative period, however data on the association with long-term mortality are lacking. We therefore sought to investigate the long-term prognostic value of cardiovascular events and myocardial necrosis following orthopedic surgery. Methods: We performed a long-term follow-up study of 3,082 consecutive subjects undergoing hip, knee, and spine surgery between November 1, 2008 and December 31, 2009. ICD-9 coding was used to ascertain patient characteristics. Perioperative complications of interest were myocardial necrosis (troponin level greater than the 99 th percentile) and coded myocardial infarction (MI) as defined by ICD-9 coding. Social Security Death Index was used to assess mortality and date of death at a mean follow-up of 3.0 ± 0.5 years. A logistic regression model was used to identify independent predictors of long-term mortality. Results: Of the 3,082 subjects, the mean age was 60.8 ± 13.3 years, 41% were male, and 65% were Caucasian. Myocardial infarction occurred in 20 (0.7%) subjects, and among 1062 with post-operatively troponin measured, myocardial necrosis occurred in 179 (16.9%) subjects. The overall incidence of death at a mean follow-up of 3.0 ± 0.5 years was 3.6%. Following multivariable logistic regression, baseline demographics associated with long-term mortality were increasing age (HR 1.04, 95% CI 1.02-1.05, P Conclusions: Perioperative troponin elevation and coded MI were independent predictors of long-term mortality. This raises the question of whether troponin should be routinely checked in the perioperative setting and whether treating patients found to have myocardial necrosis would attenuate the increased risk of long-term mortality.
Biological activities of two new substituted benzamides against mosquitoes and nontarget organisms.

L-7063 [N-((5-(4-broomopheny1)-6 methy1-pyrazinyl)amino) carbonyl)-2-chlorobenzamide] and L-1215 [(2,6-dimethoxy-N-(5-(4-(pentafluoroethoxy)phenyl)-1, 3, 4-thiadiazol-2-yl)benzamide] both show a high degree of biological activity against mosquito larvae. However, an organophosphorous-resistant strain of Culex quinquefasciatus Say showed possible tolerance to L-7063; pressuring this strain with L-7063 led to cross-resistance in four generations. This represents the first report of cross-resistance to the benzamide-type structure in mosquitoes. Both L-7063 and L-1215 are relatively safe to nontarget, aquatic organisms; although field applications do cause temporary depressions in cladocerans, the populations quickly recover.
Laboratory Response of Saddled Prominent (Lepidoptera: Notodontidae) Eggs and Larvae to Temperature and Humidity: Development and Survivorship

The effects of temperature and humidity on development and survivorship of saddled prominent, Heterocampa guttivitta (Walker), eggs and larvae were studied in environmental chambers. Between 15.6 and 26.7°C, egg and larval developmental rates increased linearly with temperature. Developmental rate of larvae was greater at saturation humidity than at lower humidities, but egg developmental rate was not significantly affected by humidity. Both egg and larval survivorship were affected by temperature and humidity. Among larvae, maximal survival occurred at saturation humidity and at 26.7°C. Among eggs, greatest eclosion success occurred at 8–3 mm Hg (75–85% RH) and at 26.7°C. Eggs incubated at 21.1°C survived extreme high and low humidities better than eggs incubated at 15.6 and 26.7°C. Results of these experiments are discussed in relation to climatic conditions actually encountered by eggs and larvae of the saddled prominent in a part of its range where outbreaks occur, upstate New York.
GEOGRAPHICAL PATTERNS AND POPULATION STRUCTURE IN PERIODICAL CICADAS BASED ON SPATIAL ANALYSIS OF ALLOZYME FREQUENCIES.

There are twelve major broods, or year classes, of 17-year periodical cicadas and three major broods of 13-year cicadas. Previous allozyme studies of three 13-year broods and two 17-year broods suggested that broods are distinct evolutionary units, exhibiting homogeneity within broods and heterogeneity among broods. Results from numerical phylogenetic analysis of allozyme data from these broods supported Lloyd and Dybas's (1966a, 1966b) evolutionary hypothesis and were consistent with biogeographical patterns. In the present paper, we use spatial statistics to extend the analysis of biogeographical patterns for periodical cicadas by examining geographic variation in allozyme frequencies within and among ten broods for the three most variable loci. The results from our analysis show that each gene frequency surface exhibits marked spatial autocorrelation. Three major geographic areas of similarity are indicated by the data: the eastern seaboard, the Mississippi Valley, and the eastern edge of the Great Plains. When localities are adjusted for regional membership, the autocorrelation disappears. In biological terms, broods are homogeneous breeding units. Geographically distinct localities within the same brood show little differentiation. Differentiation among populations within broods and among broods within regions exists but is less pronounced than the differentiation among geographic regions. For the particular enzymes examined, allozyme frequency differences appear to reflect the phylogenetic history of the broods rather than their environmental surroundings.
Study on the quality of mutton of Small Tail Han sheep in the west grassland of Jilin province

Objective Through the analysis of nutrients and heavy metals in mutton,to explore the mutton was contaminated by heavy metals in grassland,then evaluated Small Tail Han sheep meat quality on the grassland of western Jilin province. Methods To detect the treated samples used the national standard method and The United States of America ExCell inductively coupled plasma mass spectrometry(ICP-MS). Results The data showed that the lamb protein content of 19.12%, the fat content of 2.08%, rich in minerals, there was no heavy metal pollution in the mutton. Conclusion Mutton of Small Tail Han sheep has a characteristics of high protein, low fat, more mineral matter and edible safety.
Origin of Low Structures in Central Sichuan Area

The origin of structures in central Sichuan area is discussed according to its structural characteristics and the regional tectonic setting of Sichuan basin. It is considered that the structure in central Sichuan area are formed under the regional tectonic stress of Sichuan basin and the local stress derived from the basement structure and different properties during Himalayan tectonic movement. It could be divided into such two stages as the early S-N compression stage and the middle-late NE-SW compresso-shear stage.
Managing the care of patients with dementia. How to maximize level of functioning and minimize behavior problems.

PreviewSupporting and educating the primary caregiver are important aspects of treating patients with dementia. Dr Stewart, offering a fund of practical information that can be shared with caregivers, discusses how to manage many of the problems common in dementia, including depression, decompensation, abnormal sleep patterns, and wandering.
Commemorative places, political spaces: Virginia Indians, the Jamestown Quadricentennial, and the quest for sovereignty

ABSTRACTThis essay examines the cross-cultural communication strategies deployed by a coalition of indigenous tribes in Virginia to leverage the Quadricentennial commemoration of the founding at Jamestown in support of their sovereignty campaign. The tensions between Jamestown’s mythos as the “birthplace of democracy” and the natives’ historical and contemporary lived experiences, combined with the national and international attention focused on the events, constructed the 400th anniversary “celebrations” as a compelling location for social action. The coalition employed intercultural communicative practices—particularly cross-cultural dialogue and negotiation—as means of mobilizing these tensions to renegotiate their relationship with the federal government, illustrating the intersection of intercultural communication, memory, and identity.
The Artist Archives Project: David Wojnarowicz

An interdisciplinary research team at New York University recently launched the Artist Archives Project to advance research on information repositories for the display and conservation of contemporary art. The initiative responds to a growing need for museum and archive professionals to work with artists in documenting their production methods, and building knowledge for future treatment and re-activation of their work. The first undertaking of the Artist Archives Project is to create an information resource devoted to the multidisciplinary artist/activist David Wojnarowicz. Project researchers are working in conjunction with curators at the Whitney Museum of American Art who are preparing for a Wojnarowicz exhibition, along with others familiar with his work. Since the artist is deceased, most of the information comes from archives, publications, and interviews with people who knew and worked with him. The project takes a digital humanities approach by assigning equal emphasis to the content and the data...
Human Perception of Moderate Strength Low Frequency Magnetic Fields

If humans cannot perceive even subliminally that they have been immersed in or removed from a 60 Hz. magnetic field of a few gauss strength, comparable with the maximal value to be found around domestic or ELF communication systems, then it becomes very improbable that these fields have deleterious effects. With whole body immersion in a large Helmholtz coil field, some few individuals demonstrate perception scores absolutely impossible by chance, but as they are tested with acoustically quiet sources and with. better and better isolation from auxiliary nonmagnetic clues, fewer and fewer individuals show significant perception and none develop the very high scores found for sensitive subjects in the open coil systems. With an acoustically sealed isolation cabinet now being tested, perception scores may approach negligibility.
The Trial of Dwight Waldo

At a fictitious trial, Dwight Waldo is being judged by major public figures from different eras. Such an approach allows the author to simultaneously examine various intellectual perspectives inherent in the field of public administration.
Fludarabine Plus I-131 Tositumomab as Initial Treatment for Follicular Lymphoma: Half of Patients In Remission at Over 10 Years Median Followup.

Abstract 1785 Background: The sequential combination of chemotherapy and radioimmunotherapy has been shown to be effective front-line treatment for patients with follicular lymphoma (FL). We report ten-year followup results of a phase II trial of abbreviated fludarabine followed by tositumomab and I-131 tositumomab in patients with untreated follicular lymphoma. Methods: Patients with untreated follicular lymphoma received fludarabine 25 mg/m2/d for five days every five weeks for three cycles followed in six to eight weeks by tositumomab and I-131 tositumomab. Results: Thirty-eight patients were enrolled. One patient was withdrawn due to ineligible histology. The median age of eligible patients was 53 years, median time from diagnosis was 3.5 months, and 43% of patients had a high-risk FLIPI score. Two patients did not receive radioimmunotherapy; one patient had a myocardial infarction during fludarabine and was not evaluable, and one patient had persistent cytopenias following three cycles of fludarabine. All 35 patients that completed the regimen responded (ORR 100%). With a median follow-up of 128.5 months for all 37 eligible patients, the 10-year intent-to-treat overall survival is 69% and the progression-free survival is 51%. Seventeen patients have progressed (range 2–102 months). Sixteen patients remain in remission with no evidence of disease more than ten years from enrollment. Only four patients have relapsed beyond five years. Four patients have developed MDS (range 16–84 months), one of whom evolved to AML. Conclusions: Fludarabine followed by tositumomab and I-131 tositumomab is very effective at inducing long-lasting complete remissions in FL. The efficacy and long-term safety of sequential chemotherapy plus radioimmunotherapy should continue to be evaluated in the context of the range of therapeutic options for the initial treatment of follicular lymphoma. Disclosures: Furman: GSK: Speakers Bureau. Leonard: GSK: Consultancy.
A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure

Oxidative stress-induced mitochondrial DNA damage is a prominent feature in the pathogenesis of cardiovascular diseases. In the present study, we demonstrate the efficacy of a novel, mitochondria-t...
Arthroscopic Decompression of Greater Trochanteric Sciatic Nerve Impingement

Therapeutic extra-articular hip endoscopy is an effective treatment of greater trochanteric sciatic nerve impingement. We describe in detail technical pearls of the procedure including positioning, portal placement, and steps to obtaining adequate decompression while avoiding iatrogenic nerve injury.
The power of one-to-one coaching: Preparing pre-service teachers for the early childhood literacy classroom:

This article focuses on a shift in the author’s approach to teaching a literacy course to a coaching-based model after observing pre-service teachers “struggle” to implement the teaching practices during on-site fieldwork with a kindergarten, first-, or second-grade child partner. The author discusses how she provided more timely feedback and instruction by coaching the undergraduate students who were taking a course she taught while the students were working with an elementary child partner and preparing a running-record assessment. Coaching provided the pre-service teachers with a deeper level of understanding of specific literacy practices in the early childhood classroom, and it afforded them the opportunity to reflect on the objective of the literacy practice in a way that let them better use it during their own teaching.
Quantifying Isentropic Mixing Linked to Rossby Wave Breaking in a Modified Lagrangian Coordinate

AbstractIsentropic mixing is an important process for the distribution of chemical constituents in the mid- to high latitudes. A modified Lagrangian framework is applied to quantify the mixing associated with two distinct types of Rossby wave breaking (i.e., cyclonic and anticyclonic). In idealized numerical simulations, cyclonic wave breaking (CWB) exhibits either comparable or stronger mixing than anticyclonic wave breaking (AWB). Although the frequencies of AWB and CWB both have robust relationships with the jet position, this asymmetry leads to CWB dominating mixing variability related to the jet shifting. In particular, when the jet shifts poleward the mixing strength decreases in areas of the midlatitude troposphere and also decreases on the poleward side of the jet. This is due to decreasing CWB occurrence with a poleward shift of the jet. Across the tropopause, equatorward of the jet, where AWB mostly occurs and CWB rarely occurs, the mixing strength increases as AWB occurs more frequently with a ...
Gamification Framework: Using Lexical Approach on Social Media Application Online Reviews

In the field of Gamification, much work has been devoted to designing gamified software using game design elements. However, there is presently insufficient research on designing gamified software investigating both entertainment and utilitarian elements [1]. Also, there are many ambiguous uses of this technology and technical difficulties, because of the limited documentation of Gamification data usage in the industry [2]. This study is inspired by the revised lexical approach [3] to investigate Gamification framework by analyzing large-scale online SMAs’ reviews. It includes the following major steps: (1) Collecting and downloading a large body of online reviews; (2) Employing Basic Natural Language Processing techniques to build a dictionary of Gamification descriptive adjectives; (3) Extracting users ratings of adjectives; (4) Conducting factor analyses to identify Gamification traits based on adjectives; (5) Conducting card sorting technique to further simplify the complex factor structure discovered in the factor analysis. This study demonstrates a new perspective to conduct research in the intersection of Game Studies and HCI (entertainment and utilitarian aspects). Gamification traits are identified for creating design guidelines and evaluating Gamification.
AndroidLeaks: automatically detecting potential privacy leaks in android applications on a large scale

As mobile devices become more widespread and powerful, they store more sensitive data, which includes not only users' personal information but also the data collected via sensors throughout the day. When mobile applications have access to this growing amount of sensitive information, they may leak it carelessly or maliciously. Google's Android operating system provides a permissions-based security model that restricts an application's access to the user's private data. Each application statically declares the sensitive data and functionality that it requires in a manifest, which is presented to the user upon installation. However, it is not clear to the user how sensitive data is used once the application is installed. To combat this problem, we present AndroidLeaks, a static analysis framework for automatically finding potential leaks of sensitive information in Android applications on a massive scale. AndroidLeaks drastically reduces the number of applications and the number of traces that a security auditor has to verify manually. We evaluate the efficacy of AndroidLeaks on 24,350 Android applications from several Android markets. AndroidLeaks found 57,299 potential privacy leaks in 7,414 Android applications, out of which we have manually verified that 2,342 applications leak private data including phone information, GPS location, WiFi data, and audio recorded with the microphone. AndroidLeaks examined these applications in 30 hours, which indicates that it is capable of scaling to the increasingly large set of available applications.
Objectification, Sexualization, and Misrepresentation: Social Media and the College Experience

Social media use can have major impacts on one’s construction of identity, sexuality, and gender. However, some social media sites exhibit problematic and prejudiced themes through their photo and ...
Tick-Borne Infections: Beware the Tortoises Among Us

Worldwide vector-borne agents of disease continue to emerge and play ever-increasing roles as threats to blood safety likely influenced by several factors including climate and weather, changing ecosystems, human behavior, economic development, and changes in land use. While mosquito-borne agents garner most of the attention, tick-borne agents are rising in prominence, particularly with respect to blood safety risk. Most disease outbreaks associated with mosquito-borne agents of concern are ephemeral in nature and quickly transition to naive populations in new geographic locations. In contrast, tick-borne agents are generally zoonotic in nature, remaining entrenched where first identified, spreading slowly from the areas of initial establishment to new geographic regions. Tick-borne and mosquito-borne agents are thus analogous to Aesop’s Tortoise and the Hare, respectively. Hence, this chapter will focus on those tick-borne agents or “tortoises,” which in their steady plodding fashion pose expanding and ongoing threats to blood safety. Specifically, three emerging members of the deer or black-legged tick (Ixodes scapularis) “guild” will be at the core of this discussion: Anaplasma phagocytophilum which has been implicated in an increasing number of transfusion cases, the newly described Borrelia miyamotoi whose survival in blood products and transmission by blood transfusion in animal models has been documented, and the lesser known Powassan virus, unusual in that it is a tick-borne flavivirus, a group of viruses that have been transmitted by blood transfusion.
Filler free technology for enhanced thermally conductive optically transparent polymeric materials using low thermally conductive organic linkers

Abstract This work presents for the first time a non-conventional technology for higher thermally conductive optically transparent polymeric material by employing lower thermally conductive organic molecules. In last couple of decades, practically all work on thermally conductive polymer based materials has been mainly confined to conventional polymer-filler composites which comes with various challenges like high loading, expensive fillers, etc., in addition to pronounced phonon scattering at filler-polymer interface. In this work, we have thrown light on alternating yet promising strategy for thermally conductive polymer based materials without incorporating any traditional metallic, ceramic or carbon fillers. One of the fascinating fact is the achievement of effective higher thermal conductivity in spite of using constituent components with lower thermal conductivity. This was achieved by rationally designed polymer-organic molecules system where thermal conduction was induced by engineering intermolecular interaction within the polymer chain. Additionally, these materials were optically transparent. Apart from presenting these new classes of materials, this study generates some of the prominent fundamental understanding on the heat transport of polymers. Short chains of diethylene glycol (DEG) were incorporated into base polymer matrix of polyvinyl alcohol (PVA) which lead to remarkable thermal conductivity enhancement of 260% and 175% than DEG and neat PVA respectively. Phonon transport was driven by the “thermal bridges” designed through intermolecular hydrogen bonding between PVA and DEG. A further impact of the length of “thermal bridges” and its functional groups (hydroxyl, carboxyl, carbonyl) at terminal position were investigated. It was found that shorter organic molecules are more efficient in driving thermal conduction owing to less inter-chain resistance. Interestingly, these materials were found to have inverse thermal conductivity–crystallinity relationship which is usually an opposite trend to the present belief. Overall, it was found that size, molecular geometry, terminal functional group of the thermal bridging chain in host polymer are very crucial factors in determining thermal conductance. Overall, this work demonstrates an intriguing tale of engineering intermolecular interaction in polymer based material for the development of thermally conductive and optically transparent materials for thermal management applications.
Gendered: A Qualitative Interpretive Meta-Synthesis of Female Service Members at War

AbstractThis qualitative interpretive meta synthesis provides an understanding of the perspectives associated with the lived experience of women during deployment. A total of 11 studies using data ...
Chromospheres and winds of cool stars

I present data acquired during the early operations era of the HST with the Goddard High Resolution Spectrograph (GHRS) on three late-type giant and supergiant stars: α Tau (K5 III non-coronal), λ Dra (K5 III hybrid), and α Ori (M2 lab). Figure 1 shows fits to echelle (R=100,000) line profiles of three ions seen in the spectrum of α Tau. The Co II line can be fit with a single gaussian, the self-reversed Fe II line with a combination of an emission and absorption gaussian, but the unreversed C II lines require two emission gaussians of substantially different FWHM and maxima. The complex shape of the C II profiles suggests that the turbulent velocity distribution in the chromosphere is anisotropic (e.g. Gray 1988) or that the lines are formed in two regions characterized by significantly different Teff and Vturb, as in the hybrid star models of Harper (1991).
Academic Education of the Speech-Language Pathologist: A Comparative Analysis on Graduate Education in Two Low-Incidence Disorder Areas

Background/Purpose When working with a specialized population, it is necessary to have the appropriate clinical and academic training. However, many speech-language pathologists report being ill-pr...
The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and recognizes diverse DNA sequences

The quorum-sensing regulon in vibrios is controlled by the LuxR/HapR family of transcriptional regulators. In Vibrio vulnificus, this regulator is called SmcR, and it controls expression of numerous virulence behaviors, including biofilm formation and elastase production. The consensus binding site of Vibrio LuxR/HapR/SmcR proteins is palindromic, as is common for regulators that bind as dimers with helix-turn-helix N-terminal DNA binding domains. However, the LuxR/HapR/SmcR consensus site is highly degenerate and asymmetric with variations in sequence at each promoter. To determine the mechanism of DNA site recognition, we generated separation-of-function mutants of SmcR that either repress or activate transcription but not both. The SmcR N55I protein is defective at transcription activation due to loss of binding to most DNA binding sites in activated promoters but retains interaction with RNA polymerase (RNAP) alpha. SmcR S76A, L139R, and N142D are defective for interaction with RNAP alpha but retain functional DNA binding activity. Using X-ray crystallography, we show that the wild-type SmcR dimer and the three RNAP-interaction mutants exhibit two conformations of the helix-turn-helix DNA binding domain. Conversely, the SmcR N55I X-ray crystal structure is limited to only one conformation and is restricted in recognition of single base-pair variations in DNA binding site sequences. These data support a model in which two mechanisms drive SmcR transcriptional activation: interaction with RNA polymerase and a multi-conformational DNA binding domain that permits recognition of variable DNA sites. Thus, the LuxR/HapR/SmcR proteins balance specificity for quorum-sensing targets and diversity to accommodate binding at hundreds of sites genome-wide.
GCT-70. INTRACRANIAL GROWING TERATOMA SYNDROME IN CHILDREN

Germ cell tumors account for less than 5% of all intracranial malignancies in children. Intracranial growing teratoma syndrome (GTS) is a rare pathophysiologic process characterized by growth of mature teratoma elements of a non-germinomatous germ cell tumor (NGGCT) during or following treatment with chemotherapy, in addition to normalization of or declining AFP/βHCG of the cerebral spinal fluid (CSF)/serum. A 13-year-old male presented with headache, emesis, and diplopia. MRI of the brain/spine revealed a localized 3.1 x 3.1 x 3.2 cm pineal tumor. Biopsy confirmed NGGCT (germinoma, immature and mature teratoma). Serum AFP (227ng/ul) and βHCG (12 IU/L) and CSF AFP (21ng/ul) and βHCG (31 IU/L) were elevated. Prior to cycle two of chemotherapy, he developed unstable gait and moderate hearing loss. Repeat MRI brain demonstrated tumor enlargement (4.4 x 5.2 x 5.1 cm) and obstructive hydrocephalus, although serum AFP/βHCG had normalized. Gross total resection of tumor confirmed GTS, without residual immature/malignant elements. Following six cycles of multiagent chemotherapy (carboplatin, etoposide, ifosfamide) and proton beam craniospinal irradiation (36 Gy with 18 Gy boost), he remains free of disease at eleven months since diagnosis. The pathogenesis of GTS remains unclear. Care must be taken to avoid misdiagnosing GTS as progressive NGGCT, as treatment and prognosis differ significantly. Second-look surgery, with a goal of complete resection, should be considered in cases of NGGCT when residual tumor grows during or following therapy, as this may represent GTS. Although histologically benign, GTS can be fatal. In patients with GTS, complete resection is usually curative.
Nonoperative Treatment of a Periprosthetic Gout Flare in the Setting of a Positive Alpha-Defensin Result.

Abstract Gout is a rare cause of pain after total knee arthroplasty, and its presentation can be difficult to distinguish from a prosthetic joint infection. We describe a patient with left knee pain that had a history of gout and left total knee arthroplasty. Synovial fluid demonstrated monosodium urate crystals and positive alpha-defensin assay. Surgery was not pursued given a low clinical suspicion for infection and negative cultures. Her symptoms improved and ultimately resolved. There are limited case reports of periprosthetic aseptic gout flare, and only one case of concomitant positive alpha-defensin assay and monosodium urate crystals in a patient treated surgically. This case raises the possibility that patients with periprosthetic crystal arthropathy and a positive alpha-defensin test can be managed nonoperatively in the appropriate setting.