cssi/SciSciGPT-SciSciNet huggingface dataset:
Review and five new Alaskan species of the deep‐water octocoral Narella (Octocorallia: Primnoidae)

Abstract Five new species of the octocorallian primnoid genus Narella are described from seven seamounts in the Gulf of Alaska, the first records of this genus from the region between Japan and the Galapagos, and including the deepest record of the genus at 4594 m. All species are illustrated with SEM of their sclerites, often with stereo pairs of the polyps. A list of the 32 valid species of Narella is given. DNA sequence analysis using the mitochondrial genes ND6 and msh1 was determined for all five species and outgroups, but little to no variation was found among the five morphospecies, consistent with the known slow rate of evolution of the mitochondrial genes in Octocorallia.
Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition

Women constitute approximately 45% of the postdoctoral fellows in the biomedical sciences at universities and research institutions in the uSa, but a much lower percent age of women hold faculty positions. in the uS national institutes of Health (niH; Bethesda, MD) intramural research program, for example, women make up only 29% of the tenure-track investiga tors and hold just 19% of the tenured sen ior investigator appointments. a similar disparity between the ratio of men and women in independent faculty positions exists in most academic institutions across the uSa (nelson, 2005; nSF, 2004, 2006), and statistics from Europe show a similar trend of women disappearing from the higher echelons of academia (E c, 2006). the transition from postdoctoral fellow to faculty is a period during which a wor rying number of women leave academic research. Several recent surveys have tried to identify factors that lead to the attrition of women from the life sciences and engi
Monitoring distributed processes with intelligent agents

This paper describes a platform-independent application for the monitoring of distributed applications. The tool is intended for system administrators to properly distribute the components of a distributed application onto particular machines. An essential part of this tool is based on intelligent mobile agent technology used to access the target systems. Although a full implementation turned out to be infeasible due to security considerations, the implementation and experimentation indicate the suitability of intelligent agents technology for such purposes.
The Association between Auditor Quality and Auditor Size: An Analysis of Small CPA Firms:

Prior research has documented a positive association between audit quality and auditor size. While some studies have used audit fee as a surrogate for audit quality, other studies have employed mor...
Unsupervised Structure Learning of Stochastic And-Or Grammars

Stochastic And-Or grammars compactly represent both compositionality and re-configurability and have been used to model different types of data such as images and events. We present a unified formalization of stochastic And-Or grammars that is agnostic to the type of the data being modeled, and propose an unsupervised approach to learning the structures as well as the parameters of such grammars. Starting from a trivial initial grammar, our approach iteratively induces compositions and reconfigurations in a unified manner and optimizes the posterior probability of the grammar. In our empirical evaluation, we applied our approach to learning event grammars and image grammars and achieved comparable or better performance than previous approaches.
Cutaneous pythiosis in a nestling white-faced ibis

A nestling white-faced ibis (Plegadis chihi) with multifocal skin ulcerations on the wings, neck, head, and limbs was found in a wetland agricultural region of the central valley in California. Pathologic, microbiologic, and molecular findings were consistent with restricted, cutaneous infection by the oomycete Pythium insidiosum. The microscopic features of the disease, including intense, necrotizing eosinophilic and granulomatous inflammation, are similar to those previously described in mammals. Pythiosis, which is most typical in tropical and subtropical climates, has recently emerged in California as a cause of cutaneous and enteric disease in horses and dogs, respectively. Environmental stability and persistence of a ''water-mold'' in the arid central valley of California could be associated with agricultural and community watering practices. To the best of the authors' knowledge, this is the first published report of pythiosis in birds.
Bioassay of metronidazole with either anaerobic or aerobic incubation.

In a bioassay for metronidazole, a modified agar well diffusion technique was used. Two clostridial species were used as the test organisms, and, with minor variations, the method was as effective with aerobic as with anaerobic incubation. Serum and urine levels of 0.25-128 pg/ml were measurable by this method without dilution of the specimens being assayed. The principal acid and alcohol metabolites of metronidazole were found to possess only approximately 5% and 30%, respectively, of the activity of the parent compound. Metronidazole [1-(f3-hydroxyethyl)-2-methyl-5 nitroimidazole] is active in vitro against many anaerobes and appears to be promising in the
THE POLITICAL ECONOMY OF THE NATIONAL DEFENSE STOCKPILE

It is really a cynical playing of politics with this issue of the strategic stockpile. I don't like being on watch while this kind of nonsense is going on. (Humphrey, 1983, p. 67) Few government programs display both the political salability and the vulnerability to political manipulation that characterize the National Defense Stockpile. This article analyzes the ways in which changing institutional constraints have shaped the nature and extent of parochial manipulation of the National Defense Stockpile over more than half a century of U.S. stockpiling experience. Focusing on the roles of Congress and the executive branch in establishing the relevant institutional rules and accommodating constituent pressures within the framework of those rules, this article examines the use and perpetuation of the strategic materials stockpile for personal political gain.
Charged black holes in string theory

A family of solutions to low-energy string theory representing static, spherically symmetric charged black holes is described. They are labeled by their mass, charge, and asymptotic value of the scalar dilaton. The presence of the dilaton is found to have important consequences. In particular, the extremal charged "black holes" are found to be geodesically complete spacetimes with no event horizons and no singularities. Implications of these new solutions for black-hole thermodynamics and open questions in general relativity are also discussed.
SHOALING PROPERTIES OF BOUNDED LONG WAVES

Group bounded long waves which appear as a set-down under a group of high waves and a set-up in between groups are well described for constant water depth. However, their propagation into shallow water and their interaction with the constituent wave groups are not well understood and theoretically described yet. Therefore, model investigations were carried out to study shoaling properties of these second order waves in terms of amplitudes and phases. The tests give a good insight into the phenomenon and suggest distinct shoaling properties. Moreover, experimental results provide a valuable basis for future theoretical considerations.
Effects of a Novel Therapeutic Intervention in Patients With Diabetic Peripheral Neuropathy.

Abstract Objective To determine the effect of a novel therapeutic intervention called intraneural facilitation on balance measures and a neuropathy scale in patients with diabetic peripheral neuropathy. Design Prospective pre- and posttest, single group clinical trial. Setting Outpatient physical therapy clinic. Participants Patients with diabetic peripheral neuropathy (N=13). Intervention Subjects received 10 sessions of intraneural facilitation. Main Outcome Measures The modified Total Neuropathy Scale, the NeuroCom SMART Balance Master system computerized dynamic posturography (CDP) that includes the Sensory Organization Test (SOT) and the limits of stability (LOS), and the Activities-specific Balance and Confidence (ABC) scale. Results Subjects in this study showed significant improvement in the modified Total Neuropathy Scale, SOT, and 1 component in the LOS test (movement velocity). There were no significant differences in the ABC scale or in 4 components of the LOS test, which were reaction time, end point excursion, maximum excursion, and directional control. Conclusions Intraneural facilitation improved objective balance measures and neuropathy symptoms in patients with diabetic peripheral neuropathy. Further study is needed to determine long-term benefits of this intervention.
Urinalysis and Body Fluids, 6th Edition

Written by Susan King Strasinger, DA MTASCP), and Marjorie Schaub Di Lorenzo, MT(ASCP)SH, 336 pages. Philadelphia: F.A. Davis Company, 2014. $64.95. ISBN: 9780803639201. I find the textbook Urinalysis and Body Fluids to be well written and of excellent quality. The format of each chapter is clear, concise, and easy to follow. The strengths of each chapter are the understandable learning objectives, key terms, case studies, clinical situations depicted, and technical tips. The historical note with added interesting facts given is a nice touch. Highlighting the key …
Applications of High-Q Optical Microresonators in Communication

This talk summarizes various applications of high-Q resonance in optical and RF-photonic communication systems. We highlight recent advances and future challenges in high-Q microring/microdisk based photonic communication devices.
3D Petrophysical Modeling Using Complex Seismic Attributes And Limited Well Log Data

A method for 3D modeling and interpretation of log properties from complex seismic attributes (obtained from 3D post stack seismic data) is developed by integrating Principal Component Analysis and Local Linear Modeling. Complex seismic attributes have non-linear relationships with petrophysical properties of rocks. These complicated relationships can be approximated using statistical methods. This method has been tested successfully on real data sets. Log properties (sonic, gamma ray density etc.) were predicted at the location of the second well (blind well test). It has proved to work with limited log information (data from one well) whereas conventional methods, such as geostatistics, used for this purpose need well log information from several wells to correlate seismic and well data. Once the performance of the model is verified by blind well test, 3D log volumes can be calculated from 3D seismic attribute data.
Bibliography of Imported Fire Ants and Their Control: First Supplement

The red and black imported fire ants (IFA), Solenapsis invicta Buren and S. richteri Forel, now occupy more than 52 million ha in the southern United States. The literature on these controversial pests was collected in a bibliography by Banks et al. in 1978 (26). Since that bibliography was compiled, the flow of literature on IFA has increased to such an extent that a supplement is warranted.
Thermodynamic properties of alloys of gold-74/palladium-26 with variable amounts of iron and the use of Au-Pd-Fe alloys as containers for experimental petrology

Iron oxide-alloy equilibration experiments were conducted in H_2-CO_2 gas mixtures at 1 atm and 1125–1240 °C using strips of Au_(74)Pd_(26) (wt%) and produced Au-Pd-Fe alloys with 0.03–13 wt% iron. A thermodynamic calibration for the mixing of Au_(74)Pd_(26) with iron using an asymmetric regular solution leads to WG_(-Fe) = –45.0 ± 1.8 kJ/mol and WG_(-AuPd) = +19.5 ± 7.7 kJ/mol (1σ). Internal oxidation of iron was observed in a reversal experiment, suggesting that oxygen can be transferred across capsule boundaries during high-temperature experiments. This thermodynamic calibration is applicable to a wide range of oxygen fugacities and iron activities relevant to petrological and metallurgical applications at 1 atm and, as previous studies suggest excess volumes in this system are small, it can also be used to predict Fe activities in experiments at elevated pressure (up to 3 GPa). By pre-doping Au-Pd capsules to match Fe activities expected for the sample during an experiment, it is possible to maintain samples with little to no loss of iron. Pre-saturation of the capsule also provides a method for controlling the oxygen fugacity of samples if no formal oxygen buffer is available.
Prospects in International Science

This and the two following articles were presented at the Third Pugwash Conference at Kitzbuhel, Austria, September 14–20. An editorial on this conference, and the statement issued by it, were printed in the November issue. Other papers will be published in subsequent issues of the Bulletin.
Die ischämische Form des diabetischen Fußsyndroms

Diese Ubersicht befasst sich mit direkt und indirekt revaskularisierenden Masnahmen zur Behandlung der ischamischen Form des diabetischen Fus-Syndroms. Der Schwerpunkt der Darstellung betrifft infrainguinale Bypassoperationen bei Diabetikern mit kritischer Beinischamie, deren Haufigkeit im letzten Jahrzehnt rapide zugenommen hat. Auch wenn sich die Bypassoffenheit in kontemporaren Serien nicht mehr von der bei Nichtdiabetikern erreichten unterscheidet, wird bei Diabetikern noch immer ein schlechteres klinisches Ergebnis unterstellt. In dieser Arbeit soll deshalb neben dem technischen Aspekt der Bypassdurchgangigkeit v. a. der klinische Status von Diabetikern nach infrainguinaler Rekonstruktion untersucht werden. Dazu wird in einer vergleichenden Analyse das Abheilungsverhalten der pedalen Lasionen, der Beinerhalt sowie das Uberleben von Patienten mit und ohne Diabetes dargestellt.
Multistatic micro-doppler radar for determining target orientation and activity classification

Micro-Doppler radar signals can be used to separate moving human targets from stationary clutter and also to identify and classify human movements. Traditional micro-Doppler radar, which uses a single-sensor, monostatic system, suffers from the drawback that only the radial component of the micro-Doppler signal will be observed by the radar operator. This reduces the sensitivity of human-activity recognition if the movements are not directly toward or away from the line of sight to the radar antenna. In this paper, we propose overcoming this limitation through the use of a multistatic sensor, which consists of two bistatic micro-Doppler sensors. Through using multiple sensors, the orientation of oscillating targets with respect to the radar line of sight can be inferred, thereby providing additional information to the radar operator. In addition, we conclude that multiple sensors can enhance the classification of micro-Doppler signatures.
Analysis of organophosphorus pesticides residues in vegetables from 2009 to 2012 in Quzhou city

Objective To know the situation of organophosphorus pesticide residues in vegetables on the markets of Quzhou city.Methods Vegetable samples were purchased from supermarkets and farm product markets in Quzhou city.The residual quantity of the organic phosphor pesticides were detected by gas chromatography.Results There were 29 organic phosphor pesticides in 394 samples.The detection rate was 10.2%,the excessive rate was 4.3%.The results of four years showed no significant difference(P 0.05).Conclusion Effective supervision and surveillance measures should be taken strictly by related departments.
Speciation of Soil Nutrient Elements and Their Controlling Factors in Different Landuses of Typical Karst Spring Watershed

Taking two spring basins at different elevation(Bitan and Shuifang) in Jinfo Mountain of Chongqing as an example,the author discussed the soil physical-chemical properties,soil environmental quality in soil at the depth of 0-20 cm and 20-40 cm respectively and their driving factors,including pH value,organic matter,the total contents of elements(Ca,Mg,Cu,Zn,Mn) and the available species contents in woodland,bush,grassland and tilled land.The results of total and available contents of major elements in different landuses showed spatial heterogeneity in karst region.Maximum values of Calcium(Ca) and magnesium(Mg) are located at woodland of Shuifang and grassland of Bitan respectively,controlled by lithology.Both total and available contents of Ca in bottom soil layer are greater than those in surface layer,which indicate downward eluviation is more important for karst soil Ca than biological processes.Available Mg content of Bitan account for 10% of total,whereas 2% in Shuifang,and less than the average exchange Mg concentration of 4% of southern China soil.Furthermore,high Ca or Mg amount in soil seems to show a inhibitory effect on available contents of copper(Cu),zinc(Zn) and Manganese(Mn),that is to say,soil with relative low Ca and Mg amount always has higher available contents of Cu,Zn,Mn.Under the same landuse pattern,soil nutritions content at Shuifang are greater than that of Bitan.Surface soil hydrolytic nitrogen of woodland at Shuifang spring reaches 1 496.73 mg/kg,almost 5 times of that at Bitan,the former's organic matter is 23.61%,7 times of latter.It indicates that soil under forest can maintain a high level of organic matter in karst region,and Ca2+ loss in soil may cause a remarkable decrease of organic matter.With the vegetation degradation,i.e.intensify of human activities,soil nutrition contents decrease from woodland,bush-grass to tilled land.The content also decreases in soil profile from surface layer to bottom layer,with different magnitude: hydrolytic nitrogen effective potassium effective Phosphorus.
RMB Internalization:Effect, Possiblity and Strategy

RMB internalization is a process or state of RMB acting as unit of account、medium of exchange、way of payment and means of value reserve surpassing national boundaries. Internalization of RMB will not only bring China positive effect, but also will be possible. Internalization of RMB must take three-steps strategy. Now it is on the primary stage and we should continually take way to push the process of RMB internalization.
Successes and Failures in International Human Trafficking Law

The article presents a speech by Luis CdeBaca, Ambassador in combating and monitoring human trafficking at the U.S. Department of State, delivered at the symposium titled Successes and Failures in International Human Trafficking Law, held at Michigan on 5 February, 2011 in which he discusses the abolition of slavery, exploitation and sufferings of trafficking victims. He also discusses the Trafficking Victims Protection Act of 2000.
Dermatologic Diseases of Eastern Africa

Dermatologic disorders are among the five most common medical problems in rural East Africa. This article illustrates some of Eastern Africa’s more common tropical dermatologic diseases, their clinical features, and currently available treatment modalities.
Electrocaloric effect in PbZrO3 thin films with antiferroelectric-ferroelectric phase competition

Abstract Electrocaloric effect in antiferroelectric PbZrO3 thin films that undergo antiferroelectric-ferroelectric phase transition upon cooling down is investigated using atomistic first-principles-based simulations. It is found that such a phase transition is associated with a large positive electrocaloric response that can reach 13 K under electric field of 500 kV/cm. High tunability of the phase transition by the electric field leads to a wide range of temperatures associated with strong electrocaloric response. Epitaxial strain was found to provide further tunability to the electrocaloric properties. Large intrinsic electrocaloric effect at the antiferroelectric-ferroelectric phase transition and its high tunability by the electric field offer promising technological applications.
Law & Order And Natural Justice

One of the most important tenets of relativism is the fact-value dichotomy which holds that it is impossible to make judgements about good and bad from the experience of everyday life. Phenomena can tell us only what is happening; they cannout guide us in deciding how things should happen. The facts exist in the world experience, and judgements about the facts derive wholly from our wills. Thus, the values we adopt are entirely a free choice. Since all people have free will, every value choice is as good as any other. Law & Order challenges this supposition. Most plots begin with the discovery of a crime, usually a murder. Neither the police investigating the crime nor the audience has any idea why the mideed was committed or who did it. As the police look for clues, the truth slowly unfolds. Often there are false leads and the wrong person is arrested. Yet, when the truth becomes clear, it is evident who has perpetrated the offense and how he or she ought to be punished. The facts are all important in deciding what is true and therefore just. In effect, the facts quite clearly establish the "values."
A disease with a sweet tooth: exploring the Warburg effect in Alzheimer’s disease

After more than 80 years from the revolutionary discoveries of Otto Warburg, who observed high glucose dependency, with increased glycolysis and lactate production regardless of oxygen availability in most cancer cells, the ‘Warburg effect’ returns to the fore in neuronal cells affected by Alzheimer’s disease (AD). Indeed, it seems that, in the mild phase of AD, neuronal cells “prefer” to use the energetically inefficient method of burning glucose by glycolysis, as in cancer, proving to become resistant to β-amyloid (Aβ)-dependent apoptosis. However, in the late phase, while most AD brain cells die in response to Aβ toxicity, only small populations of neurons, exhibiting increased glucose uptake and glycolytic flux, are able to survive as they are resistant to Aβ. Here we draw an overview on the metabolic shift for glucose utilization from oxidative phosphorylation to glycolysis, focusing on the hypothesis that, as extreme attempt to oppose the impending death, mitochondria—whose dysfunction and central role in Aβ toxicity is an AD hallmark—are sent into quiescence, this likely contributing to activate mechanisms of resistance to Aβ-dependent apoptosis. Finally, the attempt turns out fruitless since the loss of the adaptive advantage afforded by elevated aerobic glycolysis exacerbates the pathophysiological processes associated with AD, making the brain susceptible to Aβ-induced neurotoxicity and leading to cell death and dementia. The understanding of how certain nerve cells become resistant to Aβ toxicity, while the majority dies, is an attractive challenge toward the identification of novel possible targets for AD therapy.
Epileptic Encephalopathies, CDKL5 Mutations, and Infantile Spasms

Researchers at the Mayo Clinic, Rochester, MN performed retrospective chart reviews of 6 children with epilepsy and CDKL5 mutations.
The 21-Gene Recurrence Score in Male Breast Cancer.

Given the limited data, systemic treatment of male breast cancer has been extrapolated from female patients. The 21-gene recurrence score (RS) assay estimates the risk of distant recurrence and chemotherapy benefit in early-stage, ER+/HER2− female breast cancer. We assessed the association between RS and type of treatment in male breast cancer. We identified male patients with ER+/HER2− breast cancer and available RS results treated at our institution in 2006–2016. We collected data on clinicopathologic features, treatment, and outcome. The Institutional Review Board approved the study. The study cohort consists of 38 male breast cancer patients with a median age of 70 years. Median tumor size was 1.6 cm, and 81.6% (31) were node-negative. RS was low (≤ 17) in 26 (68.4%) cases, intermediate (18–30) in 9 (23.7%) cases, and high (≥ 31) in 3 (7.9%) cases, comparable to that in female patients at our institution. All patients underwent total mastectomy, and one received radiotherapy. Thirty-four (89.5%) patients received adjuvant endocrine therapy, mostly tamoxifen (81.6%; 31). Five (13.2%) patients with intermediate or high RS were treated with adjuvant chemotherapy. No locoregional recurrence was observed, and one patient developed distant recurrence (median follow-up 34 months). The RS distribution in male breast cancers was similar to that in females treated at our institution. With limited follow-up, patients with low RS were spared chemotherapy and did not develop recurrence. Our results suggest that the RS may have a clinical utility in male breast cancer patients.
Differential Elastic Scattering Cross Sections of Boron-10 for Neutrons of 4 to 8 MeV Energy

Differential neutron cross sections of 10B for elastic scattering have been measured for ∼30 incident neutron energies between 4 and 8 Me V. Neutrons inelastically scattered from the 0.717-MeV leve...
Central Limit Theorem: New SOCR Applet and Demonstration Activity

Modern approaches for information technology based blended education utilize a variety of novel instructional, computational and network resources. Such attempts employ technology to deliver integr...
Bioengineering of Irradiated Normal Tissues by Bone Marrow Stem Cells

Irradiation damage of normal tissue during radiation therapy is repaired by stem cells and differentiated progeny derived from both the irradiated tissue and from cells migrating through the blood from the bone marrow. The bone marrow contains both pluripotential hematopoietic stem cells and their committed progenitors, and bone marrow stromal cells (mesenchymal stem cells). Using defined conditions in vitro or in animal model systems in vivo, each of these marrow origin cell populations has been shown to differentiate into multiple cell lineages. Irradiation of epithelial organs stimulates migration of bone marrow cells to sites of injury where incorporation leads to either repair of acute injury or to formation of late fibrosis. The degree to which marrow origin stem and committed progenitor cells contribute to repair of irradiation damage is not known. This chapter discusses the roles of the different marrow origin cell populations in repair of irradiation-induced damage to epithelial organs.
Effect of GABAergic and glutamatergic drugs injected into the ventral pallidum on locomotor activity.

There has been a great deal of recent interest in elucidating the behavioral role of the basal forebrain in cognitive function (Alheid and Heimer, 1988). The ventral pallidum, a part of the basal forebrain, has received a great deal of attention because of the relationship between the degeneration of neurons in this region and the symptoms of cognitive dysfunction associated with Alzheimer’s disease (Whitehouse et al., 1983; Coyle et al., 1983; Ezrin-Waters and Resch, 1986; Smith, 1988). However the ventral pallidum has also been implicated in other functions. Thus, the results of several studies have suggested that the ventral pallidum plays an important role in the regulation of movement or locomotion. This hypothesis is supported by the observations that specific neurotransmitters injected into the ventral pallidum markedly affect normal locomotion (Scheel-Kruger, 1983, 1986; Baud et al., 1988) and the locomotor stimulation produced by drugs that act on neurons in the nucleus accumbens (Mogenson et al., 1980; Heimer et al., 1982; Mogenson and Nielsen, 1983; Swerdlow et al., 1986; Mogenson, 1987; Swerdlow et al., 1986; Austin and Kalivas, 1988). In this chapter we will review these studies and report on our work indicating that quisqualic acid receptors in the ventral pallidum are involved in the regulation of locomotion induced by psychostimulant drugs.
Maps and Memorability

Things appear to us with a spatiality, a “whereness”, that we cannot ignore. Events, though they unfold over time, are said to take place. Not only do we realise that “everything is somewhere” (Robinson and Petchenik, 1976), but we record the spatiality of experience for future use. Some suggest we do this automatically or inevitably (cf Hasher and Zacks, 1979; Mandler, Seegmiller and Day, 1977); indeed, I have suggested as much (Schulman, 1973). But even if we must learn to observe and record spatiality, and even if our spatial records are incomplete or flawed, there can be no question of the existence of an “awareness of whereness” - an awareness whose implications for cognition it is my purpose here to explore.
Biomembrane structure and dynamics viewed by fluorescence.

Fluorescence is the phenomenon that certain molecules emit light with longer wavelength than the light with which they were illuminated. Such molecules are called fluorophores. Incident photons can excite a fluorophore from its electronic ground state, S 0, to a vibrational level of the electronic state S 1 or S 2. Vibrational energy is lost thermally after excitation within picoseconds, and the molecule drops to the ground vibrational state of the excited electronic state. The molecule then returns to one of the levels of S 0 after a short period of the order of nanoseconds, by emission of fluorescent light. This process is depicted in Figure 1. The absorption and emission of light is also illustrated in the Jablonski diagram of Figure 2, where the energy levels are depicted as vertical lines with energy increasing to the right. [Solvent relaxation and intersystem crossing can also be included in such diagrams (Lakowicz, 1983) but are not shown here.] The positions of the S 1 and S 2 bands in the Jablonski diagram correspond to maxima in the absorption spectrum, which is a plot of the absorbance versus wave number, proportional to transition energy (see the upper left part of Figure 2) or wavelength (see the upper right-hand side of Figure 2). The corresponding fluorescence spectra, plots of fluorescence intensity versus wave number (lower left of Figure 2) or wavelength (lower right of Figure 2), are also shown.
Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain

Experimental and modeling work of neural activity has described recurrent and attractor dynamic patterns in cerebral microcircuits. However, it is still poorly understood whether similar dynamic principles exist or can be generalizable to the large-scale level. Here, we applied dynamic graph theory-based analyses to evaluate the dynamic streams of whole-brain functional connectivity over time across cognitive states. Dynamic connectivity in local networks is located in attentional areas during tasks and primary sensory areas during rest states, and dynamic connectivity in distributed networks converges in the default mode network (DMN) in both task and rest states. Importantly, we find that distinctive dynamic connectivity patterns are spatially associated with Allen Human Brain Atlas genetic transcription levels of synaptic long-term potentiation and long-term depression-related genes. Our findings support the neurobiological basis of large-scale attractor-like dynamics in the heteromodal cortex within the DMN, irrespective of cognitive state.
Healthcare Transformation: The Electronic Health Record

Computer-based information technology (IT) is used in many industries to help people and organizations collect and analyze data more effectively. Health policy makers in the U.S. hoped that more effective and ubiquitous IT could generate similar efficiencies in the health care industry producing the dual miracles of strengthening health care quality while also reducing health care delivery costs. The digital version of the traditional patient chart, the electronic health record (EHR), is the heart of the IT systems designed to transform health care. While EHR systems have limitations, they are essential tools for storing information and facilitating communication among health care providers. Health care providers must understand this technology to use it effectively and also contribute to its ongoing evolution.
Practice for Life: Making Decisions in College

AbstractGiven that the observations in Practice for Life: Making Decisions in College are obvious to most readers, one might easily overlook the book’s importance for college student development. Yet, the findings from a longitudinal study of 36 graduates in 2010 from five residential liberal arts colleges in the Northeast provide insight into student choices and thus invite reconsideration of how best to structure student social and academic engagement. This review summarizes the book’s major topics and provides additional context for making sense of the findings.
Understanding the Open Sharing Learning Environment Online and Local Starts

Those interested in possibly contributing open-shared digital learning contents would do well to acquire a sense of the sharing ecosystem and of their distinct possible roles in that space. This chapter introduces the topic of open-shared learning online as a phenomenon with roots going back several decades. This chapter takes the learner through an environmental scan of the open-shared learning space and some methods to identify what the reader may contribute to this space—by evaluating his/her/their organizational context, skill set, interest in contributing, and other related factors.
The Columbellid species of the northeast Pacific coast from the Aleutian Islands to Cedros Island, Baja California (Neogastropoda: Columbellidae)

The neogastropod family Columbellidae is a diverse cosmopolitan group of small marine snails, with its greatest diversity in the tropics. They are represented in high latitudes, but the columbellid fauna of higher latitudes tends to be much less well documented. The present paper documents the nearshore columbellid fauna of the northeastern Pacific Ocean, from the Aleutian Islands to Cedros Island, near the dividing point between Baja California and Baja California Sur. It is based on work by J.H. McLean, and completed posthumously. Examination of the regional columbellid collections in the Natural History Museum of Los Angeles County and the Santa Barbara Museum of Natural History has resulted in 24 species in eight genera, of which four new species and one new genus are described herein. The present paper focuses on dry shell material.
Frequency of BRCA1/2 and PTEN Alterations Identified by Clinical Next Generation Sequencing.

e12550 Background: Germline alterations in BRCA1/2 result in deficiency of the homologous recombination repair pathway, which confers susceptibility to specific therapies including inhibitors of po...
Building temperature regulation in a multi-zone HVAC system using distributed adaptive control

Abstract During recent years there have been considerable research efforts on improving energy efficiency of buildings. Since Heating, Ventilation and Air-Conditioning (HVAC) systems are responsible for a big part of energy consumption, developing efficient HVAC control systems is crucial. In most of the developed approaches, precise knowledge of system parameters and/or adequate historical data is required. However, these approaches may not perform as well in the presence of dynamic parameter changes due to human activity, material degradation, and wear and tear, or disturbances and other operational uncertainties due to occupancy, solar gains, electrical equipment, and weather conditions. In this paper, we consider buildings with several climate zones and propose a distributed adaptive control scheme for a multi-zone HVAC system which can effectively regulate zone temperature by applying on-line learning and assuming exchange of information between neighboring zones. The controller of each zone achieves the local objective of controlling zone temperature by compensating for the effects of neighboring zones as well as for possible changes in the parameters of the system. Despite the exchange of information, each local controller does not know how the control actions and temperature of a neighboring zone affect the temperature of its own zone. For this reason, each local controller is estimating the parameters of the interconnections in real time and uses them together with the exchanged information to provide a more accurate local zone temperature control. The proposed method is illustrated using an example of temperature control in a six-zone building as well as a large school building, which are implemented in a Building Controls Virtual Test Bed (BCVTB) environment using EnergyPlus and MATLAB/Simulink.
Enhanced expression of the granulocyte-macrophage colony stimulating factor gene in acute myelocytic leukemia cells following in vitro blast cell enrichment.

Expression of the granulocyte-macrophage colony-stimulating factor (GM- CSF) gene in acute myelocytic leukemia (AML) was assayed by Northern blot analysis. GM-CSF messenger RNA (mRNA) was detected in the freshly obtained mononuclear cells of only one of 48 cases of AML, in contrast with recent reports that GM-CSF mRNA might be detected in half of the cases of AML when RNA is prepared from T-cell- and monocyte-depleted leukemic cells. We did find, however, that expression of the GM-CSF gene was detectable in five of ten cases after in vitro T-cell and monocyte depletion steps. Additional studies suggest that expression of GM-CSF in the bone marrow of the one positive case, rather than being autonomous, was under exogenous control, possibly by a paracrine factor secreted by marrow stromal cells. These studies emphasize the potential for altering in vivo patterns of gene expression by in vitro cell manipulation.
Strong formulations for conic quadratic optimization with indicator variables

We study the convex hull of the mixed-integer set given by a conic quadratic inequality and indicator variables. Conic quadratic terms are often used to encode uncertainties, while the indicator variables are used to model fixed costs or enforce sparsity in the solutions. We provide the convex hull description of the set under consideration when the continuous variables are unbounded. We propose valid nonlinear inequalities for the bounded case, and show that they describe the convex hull for the two-variable case. All the proposed inequalities are described in the original space of variables, but extended SOCP-representable formulations are also given. We present computational experiments demonstrating the strength of the proposed formulations.
AML with Myelodysplasia-Related Changes: Development, Challenges, and Treatment Advances.

Acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) is a distinct biologic subtype of AML that represents 25–34% of all AML diagnoses and associates with especially inferior outcomes compared to non-MRC AML. Typically, patients with AML-MRC experience low remission rates following intensive chemotherapy and a median overall survival of merely 9–12 months. In light of these discouraging outcomes, it has become evident that more effective therapies are needed for patients with AML-MRC. Liposomal daunorubicin–cytarabine (CPX-351) was approved in 2017 for adults with newly diagnosed AML-MRC and those with therapy-related AML (t-AML), and remains the only therapy specifically approved for this patient population. Other studies have also demonstrated the efficacy of the hypomethylating agent (HMA) azacitidine as upfront therapy for AML-MRC patients, which, to date, is the most common treatment employed for patients unable to tolerate the more intensive CPX-351. HMAs and venetoclax combinations have also been evaluated, but additional studies utilizing these agents in this specific subgroup are needed before conclusions regarding their role in the therapeutic armamentarium of AML-MRC patients can be reached. Currently, many studies are ongoing in attempts to further improve outcomes in this historically ill-fated patient group.
Dremel: a decade of interactive SQL analysis at web scale

Google's Dremel was one of the first systems that combined a set of architectural principles that have become a common practice in today's cloud-native analytics tools, including disaggregated storage and compute, in situ analysis, and columnar storage for semistructured data. In this paper, we discuss how these ideas evolved in the past decade and became the foundation for Google BigQuery.
Low Risk of Hypertrophic Cardiomyopathy With Contemporary Management Strategies Implemented in Non-Referral Regional Community-Based Practices.

Major advances in diagnosis and treatment have emerged for hypertrophic cardiomyopathy (HCM), largely in major tertiary referral centers dedicated to this disease. Whether these therapeutic benefits are confined to patients in such highly selected cohorts, or can be implemented effectively in independent regional or community-based populations is not generally appreciated. We assessed management and clinical outcomes in a non-referral HCM center (n = 214 patients) in Eastern Pennsylvania. Over a 6.0 ± 3.2-year follow-up, the HCM-related mortality rate was 0.1% per year attributed to a single disease-related death, in a 49-year-old man with end-stage heart failure, ineligible for heart transplant. Fifteen patients (7%) with prophylactically placed implantable cardioverter-defibrillators (ICDs) experienced appropriate therapy terminating life-threatening ventricular tachyarrhythmias. In 23 other patients (11%; 5%/year), heart failure due to left ventricular outflow obstruction was reversed by surgical septal myectomy (n = 20) or percutaneous alcohol septal ablation (n = 3). This regional HCM cohort was similar to a comparison tertiary center referral population in terms of HCM-mortality: 0.1%/year vs 0.3%/year (p = 0.3) and ICD therapy (31% vs 16% of primary prevention implants), although more frequently with uncomplicated benign clinical course (62% vs 46%; p
First Jumps of a Silicon Microrobot with an Energy Storing Substrate Spring

We present the first-ever successful jumps of a microrobot fabricated in a silicon-on-insulator (SOI) process with an energy storing spring etched into the silicon substrate. The 0.08 gram silicon robot used its onboard electrostatic inchworm motor to store 8µJ of spring energy and vertically jump more than 3mm when powered and controlled with wire tethers. The robot's vertical jump height is more than 3X higher than what has been previously demonstrated by an SOI robot.
A 0.5-/spl mu/m CMOS T/R switch for 900-MHz wireless applications

A single-pole double-throw transmit/receive switch for 3.0-V applications has been fabricated in a 0.5-/spl mu/m CMOS process. An analysis shows that substrate resistances and source/drain-to-body capacitances must be lowered to decrease insertion loss. The switch exhibits a 0.7-dB insertion loss, a 17-dBm power 1-dB compression point (P/sub 1 dB/), and a 42-dB isolation at 928 MHz. The low insertion loss is achieved by optimizing the transistor widths and bias voltages, by minimizing the substrate resistances, and by dc biasing the transmit and receive nodes, which decreases the capacitances while increasing the power 1-dB compression point. The switch has adequate insertion loss, isolation, P/sub 1 dB/, and IP/sub 3/ for a number of 900-MHz ISM band applications requiring a moderate peak transmitter power level (/spl sim/15 dBm).
Equatorial signatures of the Pacific Meridional Modes: Dependence on mean climate state

Extratropical atmospheric variability can impact tropical climate in the Pacific sector via the Pacific Meridional Modes (PMMs). The South PMM (SPMM) has a larger equatorial signature than the North PMM (NPMM) for the same amount of extratropical variability. Here we explain this interhemispheric asymmetry using an atmospheric general circulation model coupled to a slab ocean model. By imposing an anomalous interhemispheric heating gradient, we strengthen the northeasterly trades and weaken the southeasterly trades, shifting the Intertropical Convergence Zone south of the equator. As a result, the SPMM no longer influences the equatorial region while the NPMM shows strengthened linkages to the central-western equatorial Pacific. By demonstrating that background winds determine the propagation of the wind-evaporation-sea surface temperature feedback fundamental for the PMMs, we conclude that the interhemispheric asymmetry between the PMMs is largely attributed to the asymmetric mean trades in the Pacific. The results have implications for both paleoclimate studies and model development.
Common left pulmonary vein: a consistent source of arrhythmogenic atrial ectopy.

Introduction: The discovery of a consistent relationship between atrial anatomy and electrophysiology would have practical value and may provide insight into arrhythmia mechanism. We previously observed that anatomically common left pulmonary veins were a disproportionate source of atrial ectopy that was associated with the initiation of atrial fibrillation (“arrhythmogenic”). This report details our efforts to characterize and quantify this observation. Methods and Results: One hundred subjects with paroxysmal atrial fibrillation underwent computed tomographic scanning to characterize left atrial anatomy and invasive electrophysiology study to characterize events associated with the initiation of atrial fibrillation. Some of these subjects also underwent radiofrequency catheter ablation. The left pulmonary vein was common in 14 subjects and was a consistent source of arrhythmogenic ectopy. This relationship was significantly stronger than for any other individual vein or ipsilateral vein combination. Myocardium located within the common vein trunk was the site of origin of the ectopy in most subjects. This myocardium did not have unique electrophysiologic properties. Catheter ablation to isolate myocardium proximal to junction between the common vein and the left atrial body cured all patients in whom the vein was the sole source of arrhythmogenic ectopy. Conclusion: In this cohort, a common left pulmonary vein was a consistent source of arrhythmogenic atrial ectopy. (J Cardiovasc Electrophysiol, Vol. 15, pp. 560-566, May 2004)
Design and modeling of inversion layer ultrasonic transducers using LiNbO3 single crystal.

Abstract Using inversion domain engineering controlled by heating temperature, the LiNbO 3 (LNO) piezoelectric plate with both odd and even-order thickness-extensional modes can be excited simultaneously. Therefore, the inversion layer ultrasound transducer is expected to be capable of operating over a wider frequency range. In this paper, the electrical impedance and the acoustic characteristics of LiNbO 3 (LNO) inversion layer transducer have been studied by finite element modeling (FEM). The transducer designed for this study uses a 36° rotated Y -cut LiNbO 3 thin plate with an active element thickness of approximately 100 μm. First the electrical and elastic properties of the 36° rotated Y -cut LNO were obtained by transforming a basic piezoelectric matrix for Z -cut LNO. In order to validate the FEM using the transformed properties several pieces of pure and 50% inversion layer LNO were tested on the electrical impedance analyzer. The modeled impedance characteristics were consistent with the measured data. Next the model was used to design 50–60 MHz transducers using pure and 30% inversion LNO. Two λ /4 matching layers and a Tungsten loaded epoxy backing were used in these designs. The modeled results show that an over 90% bandwidth transducer can be made with proper matching and 30% inversion layer.