cssi/SciSciGPT-SciSciNet huggingface dataset:
Diabetes-related impotence in the elderly.

A multidisciplinary approach to diagnosis and treatment of impotence in the elderly diabetic man is highly desirable because of such impotence’s numerous causes, the frequent necessity for detailed diagnostic procedures, and the various treatment modalities and management alternatives available. Today, almost every older man with diabetes and impotence can obtain sexual gratification with penile vaginal intercourse if he is motivated and offered current alternative treatment modalities. Those who do not wish such treatment should be informed of alternative methods of sexual gratification.
How respondents use verbal and numeric rating scales: a case for rescaling

The dominant practice among researchers is to treat verbal rating scales as interval in nature because of the vast array of analytical techniques that this opens up when it comes to analysis. This ...
Dependence of 1.00 MeV Proton Radiation Resistance of a-Si:H Alloy Solar Cells on Cell Thickness

Rutherford bacJcscattering spectrometry has been used to determine the role of thickness and composition on the radiation resistance of a-Si:H based alloy solar cells. Single and dual-junction cells with thicknesses between about 0.23 and 1.1 microns were studied. Cells were irradiated with 1.00 MeV protons using fluences between 1E13 and 1E15 cm -2 ; the radiation resistance was determined using J-V measurements. The fluences produced significant changes in J sc . Cells with thicknesses in the 0.23 to 0.69 micron range degraded about the same when irradiated with the same fluences; thicker single-junction cells degraded with both thickness and fluence. Thirty percent Ge in a-Si x ,Ge 1-x :H cells results in poorer radiation resistance. It appears that Ge is more effective than Si in stabilizing 1.00 MeV proton-induced defects.
Effect of Oxidative LDL on Protein Expressions of Lectin Like Oxidized LDL Receptor-1 and Urokinase Type Plasminogen Activator Receptor in Normal Human Peripheral Blood Mononuclear Cells

Objective: To investigate the effect of oxidative LDL(oxLDL) on protein expressions of lectin like oxidized low density lipoprotein receptor-1(LOX-1) and urokinase type plasminogen activator receptor(uPAR) in normal human peripheral blood mononuclear cells(PBMC).Methods: The normal human PBMC was isolated by Ficoll-paque density gradient centrifugation and cultured with RPMI 1640 medium with 20% antologous serum. Western blot was conducted to detect the effect of oxLDL at different concentrations and time periods on protein expressions of LOX-1 and uPAR in normal human PBMC.Results: For 24-hour oxLDL treatment, the protein expressions of uPAR and LOX-1 were increased with the elevated oxLDL concentrations, oxLDL 50 μg/ml was the peak, while the expressions were inhibited by oxLDL 100 μg/ml. With 72-hour oxLDL treatment, the low concentration of oxLDL 10 μg/ml could not increase uPAR protein expression, while oxLDL 50 μg/ml and 100 μg/ml could effectively increase uPAR protein expression; the LOX-1 expression was increased according to the elevated oxLDL concentrations, while the expression decreased at oxLDL ≥50 μg/ml.Conclusion: Our work indicated that different concentrations and time periods of oxLDL treatment may affect the protein expressions of uPAR and LOX-1 at different degrees which suggested that oxLDL-induced inflammatory process was complicated.
Uncoupling fibrin from integrin receptors hastens fibrinolysis at the platelet-fibrin interface.

A well-characterized in vitro model system composed of thrombin- stimulated gel-filtered human platelets, fibrin-(ogen), plasminogen, and recombinant tissue plasminogen activator (rt-PA) was used to examine the relationship between platelet-fibrin adhesive interactions and the lytic resistance of a platelet-rich thrombus. Laser light scattering kinetic experiments demonstrated that the ligand-mimetic peptide D-RGDW and an anti-alpha IIb beta 3 monoclonal antibody both inhibited clot retraction, but neither integrin-targeted reagent affected the overall delay in lysis of “bulk” fibrin caused by thrombin- stimulated platelets. However, lysis of the model platelet-rich thrombus did proceed some 30% more quickly when treated with a plasminogen activator inhibitor (PAI)-resistant t-PA variant. Taken together, these results confirm that platelet-released PAI-1 is a major determinant of global lytic resistance. Next events occurring during fibrinolysis in the unique microenvironment near the platelet surface were monitored by scanning electron microscopy and quantitative fluorescence microscopy. Scanning electron micrographs of the partially lysed model thrombus in the presence of 200 mumol/L of D-RGDW showed no platelet aggregates, and fibrin was attached by fewer strands to the platelets. Quantitative fluorescence microscopy, using fluorescein- labeled fibrin, showed that fibrin adherent to the surface of thrombin- stimulated platelets lysed 20% to 50% more slowly than bulk fibrin (monitored in parallel by laser light scattering). Furthermore, this microspectroscopic technique showed that D-RGDW reduced the quantity of platelet-bound fibrin, and accelerated lysis near the platelet surface with both native rt-PA and the PAI-resistant variant. These observations suggest that the dense network of fibrin bound to the platelet surface is protected from fibrinolysis by tissue-type plasminogen activators. Further, uncoupling fibrin from its platelet receptors uniquely hastens fibrinolysis at the cell/fibrin interface.
Amino acid solutions for CAPD: rationale and clinical experience.

Abstract Protein-calorie malnutrition is present in a sizable proportion of dialysis patients. In CAPD patients, constant glucose absorption from dialysate may displace other calorie sources, such as protein, and may suppress the appetite, thus contributing to malnutrition. Use of amino acids in place of glucose as the osmotic agent has been studied extensively. Ultrafiltration and small-molecule clearance similar to that with glucose can be achieved with amino acid solutions, but nitrogenous waste produced by amino acids limits the extent to which they can replace hypertonic glucose. Side effects of CAPD with amino acids appear to be minor and easily manageable. Most studies have found at least some nutritional benefit of amino acid solutions in addition to that of lowering the glucose load. Short-term studies of amino acid solutions for dialysis indicate that they may improve protein nutrition in malnourished CAPD patients.
Can autocorrelated recruitment be estimated using integrated assessment models and how does it affect population forecasts

Abstract The addition of juveniles to marine populations (termed “recruitment”) is highly variable due to variability in the survival of fish through larval and juvenile stages. Recruitment estimates are often large or small for several years in a row (termed “autocorrelated” recruitment). Autocorrelated recruitment can be due to numerous factors, but typically is attributed to multi-year environmental drivers affecting early life survival rates. Estimating the magnitude of recruitment autocorrelation within a stock assessment model and examinations on its effect on the quality of forecasts of spawning biomass within stock assessments is uncommon. We used a simulation experiment to evaluate the estimability of autocorrelation within a stock assessment model over a range of levels of autocorrelation in recruitment deviations. The precision and accuracy of estimated autocorrelation, and the ability of an integrated age-structured stock assessment framework to forecast the dynamics of the system, were compared for scenarios where the autocorrelation parameter within the assessment was fixed at zero, fixed at its true value, internally estimated within the integrated model, or input as a fixed value determined using an external estimation procedure that computed the sample autocorrelation of estimated recruitment deviations. Internal estimates of autocorrelation were biased toward extreme values (i.e., towards 1.0 when true autocorrelation was positive and −1.0 when true autocorrelation was negative). Estimates of autocorrelation obtained from the external estimation procedure were nearly unbiased. Forecast performance was poor (i.e., true biomass outside the predictive interval for the forecasted biomass) when autocorrelation was ignored, but was non-zero in the simulation. Applying the external estimation procedure generally improved forecast performance by decreasing forecast error and improving forecast interval coverage. However, estimates of autocorrelation were shown to degrade when fewer than 40 years of recruitment estimates were available.
A novel level-of-detail technique for virtual city environments

Virtual City Environments (VCEs) and Mirror Worlds can be a useful resource for communities such as the local government, researchers and the general public to collaborate on tasks like town planning, threat assessment, commerce and research. In this work, we focus on runtime data structures and performance for Level-of-Detail (LOD) management to deliver real-time portrayal. We implement and evaluate a novel X3D-based Level-of-Detail technique called ProxyPrismLOD, which leverages the CityGML standard of a 4-step LOD hierarchy to optimally encapsulate irregularly and asymmetrically shaped building models. First, we ran a user study to understand the visual dynamics of range-based LOD switching and derived a scaling factor of 3. Second, we ran a series of simulations to study the performance benefits of ProxyPrismLOD technique over the basic range-based LOD. We observed performance benefits up to 7.46% in terms of overall Frames-per-Seconds (FPS) on the models we tested.
PbS Nanocrystal Emission Is Governed by Multiple Emissive States

Lead chalcogenide colloidal nanocrystals (NCs) are promising materials for solution processable optoelectronics. However, there is little agreement on the identity and character of PbS NC emission for different degrees of quantum confinement—a critical parameter for realizing applications for these nanocrystals. In this work, we combine ensemble and single NC spectroscopies to interrogate preparations of lead sulfide NCs. We use solution photon correlation Fourier spectroscopy (S-PCFS) to measure the average single NC linewidth of near-infrared-emitting PbS quantum dots and find it to be dominated by homogeneous broadening. We further characterize PbS NCs using temperature-dependent linear and time-resolved emission spectroscopy which demonstrate that a kinetically accessed defect state dominates room temperature emission of highly confined emitting NCs. These experiments, taken together, demonstrate that the linewidth and Stokes shift of PbS NCs are the result of emission from two states: a thermally acc...
On The Trail of Little Albert

In 1920, John Watson and Rosalie Rayner published a study of the emotional conditioning of an 11-month old infant, “Albert B,” which was to become a textbook classic. In the late 1970s, four critical reexaminations of that study revealed both a lack of scientific merit in the original work and the evolution of fictitious embellishments of it in later texts. Our analysis of leading and current introductory textbooks indicates that those critical reexaminations had but trivial effects on subsequent textbook content. Although many authors cite the critical literature, their discussions do not reflect its substance. The Little Albert legend may persist because it is an especially satisfying textbook story, to traditional behaviorist viewpoints, regardless of its validity.
On a Pathway Towards Thriving: Evaluating the Effectiveness of Tools to Promote Positive Development and Intentional Self Regulation in Youth

This article provides initial data about the reliability and validity of tools aimed at promoting youth intentional self regulation (ISR) within mentoring programs. Based on the translation of the theory-based research about ISR and youth thriving conducted within the 4-H Study of Positive Youth Development (PYD), the GPS to Success tools use the metaphor of a car’s GPS navigational system to enhance goal-directed behaviors among youth. The core GPS tools are “growth grids,” designed to help mentors appraise ISR skill development and to link these skills to other grids assessing the Five Cs of PYD and Contribution. Data from 152 mentor and youth pairs from 4-H program sites in Oregon and North Carolina indicated that the growth grids were generally reliable. Although validity evidence was mixed, rubrics for “G” and “P” and for a global GPS score were related to a well-validated measure of ISR.
High Molecular Weight Kininogen Fragments Stimulate the Secretion of Interleukin 1β through the Urokinase-Type Plasminogen Activator Receptor (uPAR) and CD11b/CD18 (Mac-1) in Human Blood Mononuclear Cells.

High molecular weight kininogen (HK) is known to bind specifically and saturably to Mac-1 with a Kd = 9–18 nM for neutrophils and to uPAR with a Kd =30 nM for endothelial cells. However, the functional results of HK interaction with Mac-1 or uPAR on leukocytes is not fully understood. Kallikrein cleavage of single chain HK to a two chain form (HKa) with release of bradykinin (BK) occurs in sepsis, arthritis, and inflammatory bowel disease. We hypothesized that HKa stimulates secretion of inflammatory cytokines. Mononuclear cells were isolated from normal subjects by a Histopaque density gradient. We have expressed kininogen domain 3 (D3) and a fragment of domain 3, coded for by exon 7, E7P (aaG235-Q292), in E. Coli as glutathione S-transferase (GST) fusion proteins. HK and HKa were purified proteins. GST was recombinant. All proteins contained 6 /ml mononuclear cells/ml were preincubated with monoclonal antibodies, murine IgG (both at 1.8 mM) or HANKS buffer containing 0.15 M NaCl, pH 7.4 for 30 minutes at 37°C. HK, HKa, GST-D3, GST-E7P, GST-D5 or GST all at 600 nM were added. Centrifugation allowed separation of the mononuclear cell suspension into cells and supernatant. The latter was used for assay of interleukin-1β (IL-1β) by ELISA. HK and all fragments tested stimulated secretion of IL-1β of 84.8 to 306.3 pg/ml when incubated with mononuclear cells for 30 minutes at 37°C. Anti-Mac-1 antibody inhibited IL-1β secretion by HK 100%, by HKa 89%, by GST-D3 78%, by GST-E7P 94% and by GST-D5 98%. Anti-uPAR antibody inhibited IL-1β release by HK 88%, by HKa 77%, by GST-D3 95%, by GST-E7P 85%, and by GST-D5 76%. Inhibition by both receptor antibodies is consistent with their known complex formation. A monoclonal antibody (mAb) to HK D5 (C11C1) and a mAb to HK D3 (2B5) both inhibited IL-1β release by HK, HKa, GST-D5 and GST-D3 indicate that both D3 and D5 are important in cytokine release. Murine IgG gave 0% inhibition in all studies. These results indicate that kininogen may contribute to the pathogenesis of inflammatory diseases by releasing IL-1β from human blood mononuclear cells.
Daptomycin (DAP) Use in Patients with Hematologic (HEM) Cancer History; Post-Marketing Experience in a Registry.

Abstract Background: DAP is a novel lipopeptide antibiotic, approved for complicated skin and skin structure infections, with potent in vitro activity against many resistant Gram-positive organisms. Registration studies often limit or exclude patients with severe illness. Antibiotic resistant Gram-positive pathogens are frequently encountered in compromised patient populations; however, minimal information is available pre-approval in these patients. Methods: Cubicin® Outcomes Registry and Experience (CORE) is a Phase IV retrospective observational chart review (45 institutions) to quantitate characteristics and clinical outcomes of patients (pts) receiving DAP. A standard case report form including demographic, disease state, clinical, and microbiologic data was completed by each investigator. Cure, failure, and improvement were assessed using standard definitions. Nonevaluable pts had insufficient data available to determine clinical outcome. Of the 1160 pts in CORE, 56 were reported with a history of HEM cancer. Eighteen (32%) were nonevaluable; 6 of those expired. This report describes the 38 pts with an assigned outcome. Results: Fifty-five percent of pts were female, 63% were 31 to 65 years of age, and 76% of infections developed in a hospital setting. Common comorbidities included cardiovascular disease (24%), immunosuppression (18%), and transplant (11%). The most common infections were; bacteremia catheter-related (53%), skin and skin structure (34%), and bacteremia noncatheter-related (18%). Seventy-one percent (27/38) of pts were culture positive before DAP with the most common pathogens being Enterococcus sp. (52%, of which 71% were VRE), coagulase-negative staphylococci (41%), and S. aureus (19%, of which 80% were MRSA). A high percentage of pts (92%) received antibiotics (abx) prior to DAP. The most frequent initial dosing regimens were 4mg/kg QD (50%), and 6mg/kg QD (29%). The mean duration of DAP therapy was 13.6 days (range 2–44). Dose (P=0.3) and duration (P=0.58) did not vary by primary pathogen. Twenty-nine (76%) pts received concomitant abx therapy, most commonly with fluoroquinolones (31%), metronidazole (28%) or cephalosporins (24%). The mean time to clinical response was 2.4 days (n=28) and unaffected by primary pathogen (P=0.43) or the influence of concomitant abx therapy (P=0.55). All pts were reported as cured (66%) or improved (34%). Conclusion: The data from the CORE registry demonstrates that DAP shows early clinical response and clinical cure for HEM patients where catheter associated infections and VRE are prevalent. These data provide preliminary data on the use of DAP in this compromised patient population. This information should lead to further prospective studies in cancer patients with DAP.
Infarcted neuroendocrine tumor following endobronchial ultrasound guided fine needle aspiration of a pulmonary nodule: Typical versus atypical carcinoid a pathological diagnostic dilemma

Abstract Introduction Pulmonary Neuroendocrine tumors have been categorized into high, intermediate and low grade. The distinction between low grade typical carcinoid from atypical carcinoid depends on mitotic count and presence of punctate necrosis. Case presentation The patient is a 60year old female with past medical history of diabetes mellitus, hyperlipidemia, gastrointestinal reflux disease and cervical myelopathy. An incidental right upper lobe nodule was discovered during hospitalization for post-total knee arthroplasty sepsis. Follow-up CT and PET scans demonstrated size stability with mild hypermetabolic activity. The tumor was excised by a robotic thoracoscopic right upper lobectomy and mediastinal lymph node dissection. A lobulated, tan-yellow, well demarcated firm mass, measuring 1.2×1×1cm was grossly identified. Microscopically, the well circumscribed mass demonstrated near complete infarct-like central necrosis with a peripheral viable cellular rim consisting of nests of tumor cells that stained positively with TTF-1, Synaptophysin, Chromogranin, and CD56; and was negative for calcitonin and monoclonal CEA. The mitotic figure count was negligible and met the WHO criteria for typical carcinoid. The proliferative index (Ki-67) was slightly high at 9.29%. Discussion The unusual central necrosis seen in the tumor and the relatively high proliferative index created a pathological diagnostic dilemma discussed in this report.
Beyond measures of language performance

Researchers and clinicians engaged in the study and treatment of aphasia have made substantial progress over the past 30 years. Substantial improvements have been made in the development of models ...
Focusing properties of a cascaded asymmetric microstructure under Gaussian beam illumination

We compare the focusing of Gaussian and plane wave illumination for a cascaded asymmetric microstructure. Although the Gaussian beam generates a longer and wider photonic nanojet, it can still focus efficiently for non-optimal microstructure geometries.
Population Base Rates and Disease Course of Common Psychiatric and Neurodegenerative Disorders

Knowledge of population base rates of neurological and psychiatric disorders is fundamental for diagnostic decision making. Consideration of relevant probabilistic information can improve diagnostic efficiency and accuracy. However, such data continue to be misused or underutilized, which can lead to misdiagnoses and negative patient outcomes. The aim of the current review is to create an easily accessible and comprehensive reference of existing age of onset as well as prevalence and incidence data for common neurodegenerative and psychiatric disorders in adults. Relevant epidemiological data were compiled from well-respected and frequently-cited textbooks and scholarly studies. Reviews were collected from PubMed, and publicly-available sources were gathered from Google Scholar. Results are organized and presented in several tables and a figure, which can be used as a diagnostic guide for students and clinicians across healthcare disciplines.
Atypical Presentation of Acute Angle-Closure Glaucoma in Maroteaux-Lamy Mucopolysaccharidosis with Patent Prophylactic Laser Peripheral Iridotomy: A Case Report.

Introduction Maroteaux-Lamy syndrome (MLS) is a rare progressive condition characterized by inflammation and scarring of multiple organs. Ocular complications caused by anterior segment abnormalities commonly cause visual impairment in MLS. Angle-closure glaucoma is one such complication, but there are limited data on presentation, workup, and management of this condition. Case presentation This case report describes an atypical presentation of acute angle-closure glaucoma in a patient with MLS despite a prior prophylactic laser peripheral iridotomy-which would typically prevent an acute angle-closure attack-that was patent and intact at the time of angle closure. Discussion Because of severe congenital anterior segment crowding, high axial hyperopia, and constant accommodative demand in patients with MLS, we recommend performing two prophylactic laser peripheral iridotomies simultaneously in the same eye instead of one. The mechanism for this indication differs from that in patients at risk of acute angle-closure glaucoma because of lens zonulopathy alone. We hope that this case report may help prevent vision loss and optimize quality of life in patients with MLS who may be wheelchair-bound but are typically high functioning with normal intelligence.
Improving the patient (pt) experience through physician engagement.

e17641 Background: At the University of Utah’s Huntsman Cancer Institute (HCI), we assess pt experience using a nationally based private survey company. Although ranking highly on the inpatient units, HCI’s outpatient clinics were at the fifth percentile nationally in 2005. Physicians were focused on academic objectives including research, teaching, clinical care, and medical outcomes. In recent years, there has been heightened interest in pt experience as a quality indicator. HCI developed novel strategies to increase physician engagement in improving pt experience. Methods: We designed interventions aimed at engaging the physicians by taking advantage of common physician traits such as being successful, competitive, scientific, and being outcomes-focused. These traits drove the interventions that were implemented including organizationally changing the traditional academic definition of success to include the patient experience, an unblinded physician ranking, and specific physician/team meetings to add...
Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease.

Abstract Objective Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic liver disease that is characterized by severe peri-biliary tract inflammation and fibrosis, elevated oxidative stress and hepatocellular injury. A hallmark of PSC patients is the concurrent diagnosis of Inflammatory Bowel Disease occurring in approximately 70%–80% of PSC patients (PSC/IBD). The objective of this study was to determine the impact of end stage PSC/IBD on cellular antioxidant responses and the formation of protein carbonylation. Methods Using hepatic tissue and whole cell extracts isolated from age-matched healthy humans and patients diagnosed with end stage PSC/IBD, overall inflammation, oxidative stress, and protein carbonylation were assessed by Western blotting, and immunohistochemistry. Results Increased immunohistochemical staining for CD3 + (lymphocyte), CD68 (Kupffer cell) and myeloperoxidase (neutrophil) colocalized with the extensive Picrosirius red stained fibrosis confirming the inflammatory aspect of PSC. Importantly, the increased inflammation also colocalized with elevated periportal post-translational modification by the reactive aldehydes 4-HNE, MDA and acrolein. 4-HNE, MDA and acrolein IHC all displayed a significant component in hepatocytes adjacent to fibrotic regions. Furthermore, acrolein was also elevated within the nuclei of periportal inflammatory cells whereas MDA staining was increased in hepatocytes across the lobule. Prussian Blue staining, when compared to the positive controls (ALD, NASH), did not display any evidence of iron accumulation in PSC/IBD livers. Western analysis of PSC/IBD anti-oxidant responses revealed elevated expression of SOD2, GSTπ as well as upregulation of Akt Ser473 phosphorylation. In contrast, expression of GSTμ, GSTA4, catalase, Gpx1 and Hsp70 were suppressed. These data were further supported by a significant decrease in measured GST activity. Dysregulation of anti-oxidant responses in the periportal region of the liver was supported by elevated SOD2 and GSTπ IHC signals in periportal hepatocytes and cholangiocytes. Expression of the Nrf2-regulated proteins HO-1, NAD(P)H quinone reductase (NQO1) and Gpx1 was primarily localized to macrophages. In contrast, catalase staining decreased within periportal hepatocytes and was not evident within cholangiocytes. Conclusions Results herein provide additional evidence that cholestasis induces significant increases in periportal oxidative stress and suggest that there are significant differences in the cellular and subcellular generation of reactive aldehydes formed during cholestatic liver injury. Furthermore, these data suggest that anti-oxidant responses are dysregulated during end-stage PSC/IBD supporting pathological data. This work was funded by NIH 5R37AA009300-22 D.R.P.
An adjacency matrix approach to delay analysis in temporal networks

Wireless communications networks are often modeled as graphs in which the vertices represent wireless devices and the edges represent the communication links between them. However, graphs fail to capture the time-varying nature of wireless networks. Temporal networks are graphs in which the sets of nodes or edges are time-varying. We consider the most common case, in which the set of nodes is fixed but the presence of edges changes over time. Most previous work on analyzing temporal networks has focused on summary measures that combine the contributions of different paths by using different weights for paths with different delays. Such summary measures are efficient to compute but may lose valuable information about the temporal behavior of the network. We propose techniques that characterize the delays of all paths between nodes in temporal networks. We then apply these techniques to identify dominant patterns in the temporal paths connecting nodes. Example temporal networks are used to illustrate these phenomena, and we consider implications to wireless networks.
Electriogram of Associative «Shu-Points» as A Diagnostic Tool for Diseases of the Internal Organs

The heart generates the strongest and most extensive rhythmic electromagnetic field in the body As all cells throughout the body are oriented according to the magnetic vector of the heart the heart has a powerful influence on everybody process The activity of immune cells is closely connected to their polarity when immune cells become depolarized they are deactivated as a result nbsp We hypothesize that the heart rsquo s electromagnetic signals are distributed throughout the body via the network of acupuncture meridians similar to the manner in which the heart propels blood throughout the body via blood vessels The heart rsquo s electromagnetic system governs the structure and organization of tissues as well as the potential ndash and thus the activity ndash of all the body rsquo s cells including immune cells This method of communication is implied in the control of cell proliferation and its failure in a bodily organ contributes to the cancer process nbsp Our aim was to determine whether we could monitor the electromagnetic activity in acupuncture points back SHU points and record this activity with electrocardiogram or electroencephalogram In our preliminary trial we succeeded in recording this electromagnetic activity using electrogram to record activity in back SHU acupuncture points also known as Associated Points or Paravertebral Reflex points but not in an inactive neighboring area control or ldquo sham rdquo points We found that the wave shape of electromagnetic activity recorded at SHU points was different in the presence of pathological conditions in a given internal organ while it remained constant in SHU points representing healthy organs In conclusion our preliminary research offers additional proof for the existence of a sovereign system of biological control over the organization and activity of all bodily tissues governed by the electromagnetic field generated by the heart and distributed through the network of acupuncture meridians Our research leads us to believe that the immunomodulating effect of acupuncture results from the restoration of tissue cell structure and cell potential The stimulation of acupuncture points restores the receptivity of target tissues and immune cells to the heart rsquo s electromagnetic signals thereby restoring the cells rsquo polarity and functional activity nbsp
Luminal A Breast Cancer and Molecular Assays: A Review

Purpose Chemotherapy has been the historical mainstay of treatment for patients with breast cancer, with immunohistochemical markers and tumor characteristics driving treatment decisions. The discovery of different intrinsic subtypes of breast cancer has advanced the understanding of breast cancer, with gene-based assays shedding further light on tumor behavior and response to treatment. Design This review focuses on the landscape of the luminal A subtype, its definition based on immunohistochemistry (IHC) and gene assays, the prognostic and predictive value of these assays, guideline recommendations, and treatment implications. Results Clinical studies of the prognostic value of gene-based and IHC-based assays in patients with luminal A-subtype breast cancers suggest a better prognosis for these patients compared with those with breast cancers of other subtypes. Conclusion In today's era of precision medicine, the best treatment regimen for patients with luminal A-subtype tumors is still undetermined, but available data raise the question whether chemotherapy can be omitted and endocrine therapy alone is sufficient for this patient population. Implications for practice Immunohistochemical markers have traditionally guided treatment decisions in breast cancer. However, advances in gene-expression profiling and availability of gene-based assays have launched these newer tests into everyday clinical practice. Luminal A-subtype tumors are a unique subset that may have favorable tumor biology. Properly defining this tumor subtype is important and may identify a subset of patients for whom endocrine therapy alone is sufficient.
Maxwell: A semi-analytic 4D code for earthquake cycle modeling of transform fault systems

Abstract We have developed a semi-analytic approach (and computational code) for rapidly calculating 3D time-dependent deformation and stress caused by screw dislocations imbedded within an elastic layer overlying a Maxwell viscoelastic half-space. The maxwell model is developed in the Fourier domain to exploit the computational advantages of the convolution theorem, hence substantially reducing the computational burden associated with an arbitrarily complex distribution of force couples necessary for fault modeling. The new aspect of this development is the ability to model lateral variations in shear modulus. Ten benchmark examples are provided for testing and verification of the algorithms and code. One final example simulates interseismic deformation along the San Andreas Fault System where lateral variations in shear modulus are included to simulate lateral variations in lithospheric structure.
Conflicts of Interest in Clinical Guidelines: Lack of Authors and Disclosures in the AAOMS White Papers.

Purpose The purpose of this study was to evaluate current state of authorship, financial disclosures, and conflicts of interest in position papers published by the American Association of Oral and Maxillofacial Surgeons (AAOMS). Materials and Methods This is a cross-sectional review of the position papers published by the AAOMS from 2013 to 2017. Primary outcome variables include position papers published by the AAOMS. Secondary outcome variables include declaration of authorship, financial disclosures, and financial payments. The Open Payments Database for financial disclosures was reviewed for the year the position paper was published and the immediate preceding year. Results Ten position papers were published by the AAOMS from 2013 to 2017. Of the 10 papers, authorship was listed in 3, and none explicitly addressed the presence or absence of financial disclosures or conflicts of interest. Contributors to 3 of the 3 authored papers were found at review of the Open Payments Database to have received industry funding in the year the position paper was published and the immediate preceding year. The remuneration ranged from less than $1,000 to $554,006.02. Conclusion Position papers published by the AAOMS lack standardization for authorship and statements on potential financial disclosure. The authors suggest full disclosures of authorship and authors' conflicts of interest should be stated on all position papers to provide transparency to the process.
Suspended stripline diplexer design using low pass and high pass filters

This paper presents the design of low insertion loss diplexer using Suspended Stripline (SSL) technology. The low pass and high pass channels cover bandwidth of 10MHz-2.2GHz and 2.2GHz-6GHz respectively. The design and simulation of diplexer are carried out using ADS (Advanced Design System). Final simulation and optimization is performed in 3D EM simulator Sonnet. The designed diplexer is fabricated and tested. Insertion loss of less than 1 dB is achieved for both channels. Simulated and measurement results are presented with good agreement and diplexer performs well up to 6 GHz.
Trading Aggressiveness and Market Breadth Around Earnings Announcements

In a single market, liquidity supply has two dimensions--price measured by the quoted spread, and quantity measured by the quoted depth. A third liquidity dimension, market breath, should be added when multiple markets quote the same security and there are enforceable regulatory penalties for a violation of price priority. We define the breadth of the market as the number of quoting market centers matching the best prices, by side of the market. Regulation NMS introduced a price priority rule mandating that orders be routed to the exchange with the best prices, which, in turn, led to the establishment of high speed communications connections between markets. We study liquidity around earnings announcements for NYSE firms. We find that liquidity suppliers significantly decrease market breath prior to earnings announcements, and that large uninformed liquidity demanders significantly increase their use of Intermarket Sweep Orders (ISOs). ISOs are a more aggressive and expensive trading strategy. In post Regulation NMS markets, we show that market breadth is an important measure of liquidity and significantly affects the level of aggressive trading in the market.
Simulation in Force Spectroscopy

Simulation has played an important role in the study of molecular-scale forces since the 1970s, almost from the time such forces could first be measured experimentally. Over the past three decades, as experimental probes have grown in sophistication and sensitivity, the scope and accuracy of computer modeling have developed in step. Today simulation and experiment are so closely linked in the field of force spectroscopy that it seems hardly possible to consider one without the other. Although the influence of simulation is certainly growing, with some notable exceptions the frontier has to this point been driven largely by experiment. In comparison to pencil-and-paper theory, which has been extremely successful in helping to define unifying concepts and analytical frameworks, the principle contribution of computation has been to fill in missing details, and to clarify and help explain experimental findings. This role is beginning to change, however, as steady advances in methodology and computer hardware expand the versatility and reliability of modeling approaches, and improving software makes it increasingly feasible for scientists without backgrounds in simulation to adopt these techniques in their own research.1 Modeling is becoming both increasingly predictive, and increasingly accessible. Another emerging role for simulation in the field of force spectroscopy is to investigate questions experiments cannot address, such as the study of phenomena occurring on very short time and length scales, atomic-scale structure or energy flow, and the distribution of forces among simultaneously interacting contacts. A simple example occurs in the study of force-separation curves. In an experiment, mechanical instability in the transducer may prevent portions of the force spectrum from being measured, or limit sensitivity by requiring a stiffer spring constant. In a simulation however, where forces can be applied in any arbitrary way, or parts held fixed at arbitrary positions, one can study scenarios which may not be achievable by experiment, even in principle. As we will see throughout, this powerful advantage has been used in a number of studies to shed light on phenomena that might have otherwise gone unrecognized, or worse, been misinterpreted. This chapter aims to provide an introduction to the role of simulation in force spectroscopy. I survey the most important computational techniques, including a discussion of their strengths and weaknesses. Particular attention is given to the difference in timescales probed by experiments and simulation, and the consequences this has for comparing results from the two approaches. The chapter concludes with a discussion of some selected case studies, 6
PARP inhibitor combination therapy in desmoplastic small round cell tumors.

e23212Background: Desmoplastic small round cell tumor (DSRCT) is a rare but pernicious mesenchymal neoplasm that expresses the EWS-WT1 gene fusion transcript. It has similar histopathology to Ewing...
Abstract B21: Epigenetic modifiers MLL1 and JMJD3 regulate neuroblastoma tumorigenicity by maintaining a cancer stem cell-like population

High-risk neuroblastoma (NB) represents a major clinical challenge in pediatric oncology. Despite significant dose escalation of intense therapies, long-term survival for NB patients remains poor ( Citation Format: Saurabh Agarwal, Julie Tomolonis, Sanjeev Vasudevan, Jason Shohet. Epigenetic modifiers MLL1 and JMJD3 regulate neuroblastoma tumorigenicity by maintaining a cancer stem cell-like population [abstract]. In: Proceedings of the AACR Special Conference: Pediatric Cancer Research: From Basic Science to the Clinic; 2017 Dec 3-6; Atlanta, Georgia. Philadelphia (PA): AACR; Cancer Res 2018;78(19 Suppl):Abstract nr B21.
High-Throughput Targeted Quantitative Analysis of the Interaction between HSP90 and Kinases.

Kinases, which function in numerous cell signaling processes, are among the best characterized groups of client proteins for the 90-kDa heat shock protein (HSP90), a molecular chaperone that suppresses the aggregation and maintains the proper folding of its substrate proteins (i.e., clients). No high-throughput proteomic method, however, has been developed for the characterizations of the interactions between HSP90 and the human kinome. Herein, by employing a parallel-reaction monitoring (PRM)-based targeted proteomic method, we found that 99 out of the 249 detected kinase proteins display diminished expression in cultured human cells upon treatment with ganetespib, a small-molecule HSP90 inhibitor. PRM analysis of kinase proteins in the affinity pull-down samples showed that 86 out of the 120 detected kinases are enriched from the CRISPR-engineered cells where a tandem affinity tag was conjugated with the C-terminus of endogenous HSP90β protein over the parental cells. Together, our results from the two ...
Exploring the application of topographic indices in urban areas as indicators of pluvial flooding locations

In urban areas, the presence of impervious surfaces limits natural drainage and routes water to stormwater infrastructure with finite capacity, making these areas especially prone to flooding. Though large floods are responsible for endangering lives and causing extensive damage, there is growing evidence that more frequent floods with shallow water depths, termed nuisance flooding, can have a high cumulative cost and many direct and indirect damages. To determine whether locations of nuisance flooding may be linked to topography, we took a parsimonious, spatially distributed approach to explore whether high topographic index values co‐occur with citizen‐reported nuisance flooding. We obtained nuisance flood reports from the municipal data service 311 for several watersheds in New York City and Baltimore, USA. Our analysis tested two topographic indices (TI)—topographic wetness index (TWI) and sink depth—both calculated from high‐resolution (~1 m) digital elevation models. Generally, our findings suggest that not all but many locations of reported flooding tend to coincide with deep sinks or large TWI. However, nuisance flooding reports most commonly coincided with deep sinks and high TWI when using a maximum, instead of coincident, TI value extracted around each reported location of flooding, an approach we used due to the uncertainty in location accuracy of flooding reports. Overall, our results show promise for application of topographic indices, typically applied in more natural settings, as indicators of nuisance flooding areas in urbanized environments. Although limitations to this approach exist, the application of TIs and crowd‐sourced reporting in tandem could provide a useful starting point for mapping flood‐prone areas in many cities with technologically adept community members and ample geospatial data.
Extracorporeal Membrane Oxygenation Use in Acute Myocardial Infarction in the United States, 2000 to 2014.

Background: Extracorporeal membrane oxygenation (ECMO) is increasingly used in acute myocardial infarction (AMI); however, there are limited large-scale national data. Methods: Using the National I...
Lithofacies-dependent rock-physics templates of an unconventional shale reservoir on the North Slope, Alaska

AbstractOver the past 20 years, oil and gas companies have turned their attention to producing petroleum directly from organic-rich shale. Successful exploration, appraisal, and production strategi...
RNA secondary structure prediction using Fruit Fly Optimization Algorithm

RNA Secondary Structure Prediction (RSSP) is an optimization problem, where a stable secondary structure is acquired from an RNA primary sequence. Many exact, heuristic and metaheuristic algorithms established in recent years to solve the RSSP problem. We have resolved an accession based on metaheuristic algorithm named Fruit Fly Optimization algorithm to solve the RNA secondary structure prediction problem. FOA is a population-based metaheuristic that works better than all other related existing algorithms and has been employed in different optimization problems. We have redesigned the operators of the FOA algorithm and calculated the minimum Gibbs free energy (ΔG) of the structure to solve the RNA secondary structure problem. We have a Repair function which is known as novel operator that is used to verify and expel the repeated stem from RNA sequence, which is very time-efficient. Every quality of the solutions and spending time are calculated in designing the operators and the repair function. The raised methodology gives efficiency, robustness, and effectiveness in solving the RSSP problem.
Desinformação no contexto da pandemia do Coronavírus (COVID-19)

O professor Dr. David Nemer responde questoes sobre o conceito de desinformacao, os elementos que contribuem para a disseminacao de desinformacao e o seu impacto no contexto da pandemia do Coronavirus.
Адаптивное управление нелинейным объектом типа конвертоплан в условиях неопределенностей

Purpose of research . The article deals with the problem of monitoring water areas in order to control their physical and chemical conditions using a flying laboratory (FL) which includes an aircraft with attachable water intake equipment and a software and hardware system. A specific feature of the monitoring of surface waters is the unpredictable behavior of air and water, periodic absence of visual contact with the aircraft, the uncertainty of tricopter characteristics. Therefore, the purpose of this article is to study the parameters of the control system (CS) to meet the requirements for the accuracy of aircraft positioning in conditions of uncertainty of external parameters. Methods. Theoretical mechanics and robot mechanics methods were used to solve the set tasks. Methods for mathematical modeling of dynamic systems were used to study the patterns of convertiplane movement. Adaptive control with a reference model were used to plan and control the movement of the aircraft. Results. The use of adaptive FL motion control made it possible to ensure convergence to zero of the tracking errors i.e., the difference between the output signals and the reference model. The proposed control system gives a good result with small disturbing effects. The parameters of the regulator that ensure the quality indicators of the ACS within the specified limits are determined. Conclusion. A mathematical model was developed and mathematical modeling of the convertiplane movement under conditions of uncertainty of external influences was performed. The problem of parameter control of a convertiplane was considered when the control coefficients were available for setting. The developed algorithms in the adaptive control system made it possible to provide faster suppression of external disturbances in comparison with the traditional PID control system for the case of a linear description of the controlled object.