cssi/SciSciGPT-SciSciNet huggingface dataset:
Collateral Support: Involving Parents and Schools in Treatment for Youth Anxiety

ABSTRACTCognitive behavioral therapy (CBT) is an empirically supported and well-established treatment for youth anxiety disorders. CBT therapists often involve parents and school staff in treatment to promote the generalization of therapeutic gains across settings. To facilitate therapist communication with those who provide collateral support, we discuss both general guidelines and specific examples of how parents and teachers can best support anxious youth by acting as coping models, labeling and validating anxious feelings, rewarding brave behavior, and reducing accommodations. We provide answers to questions commonly asked by parents (e.g., “How should I respond ‘in the moment’ when my child is anxious?”) and by school personnel (e.g., “What is a useful role for a school in child treatment”). Handouts summarizing main concepts for parents and schools are provided.
Synthesis, Magnetic, Electrical and Mössbauer Investigations on Complex Semiconductors

The system Ba-Fe-S contains a phase Ba1+xFe2S4 whose structure consists of infinite chains of FeS4 edge sharing tetrahedra with Fe-Fe distances of 2.7A. The chains are 6 A apart and Ba2+ fills the space between the chains. Each value of x designates a distinct phase and such structures have been labeled “infinitely adaptive.” The Ba1+xFe2S4 compounds are anisotropic semiconductors. The room temperature electrical conductivity for the x = 0 and x = 0.086 phases changes by nearly 6 orders of magnitude as increasing x populates the conduction band. The preparation of these materials requires very careful control of sulfur vapor pressure in closed ampules at elevated temperatures. A similar effect is observed in rare earth sulfides with the Th3P4 structure. Intrinsic La2S3 and BaLa2S4 are predicted to be high resistivity semiconductors. As the composition changes to a stoichiometry such as Ba0.8La2.2S4 the behavior becomes semi-metallic. Control of the sulfur vapor pressure will be a critical parameter for designing physical parameters into these compounds.
Characteristic Pressure Pulses Recorded with an Esophageal Balloon in Experimental Mitral Insufficiency in Dogs.

Summary and ConclusionsPulsations in the esophagus at the level of the left atrium and pressure pulses within the left atrium were simultaneously recorded in normal dogs and in the same animals following the production of mitral insufficiency.An identifiable and consistent pattern in the esophageal tracings was observed in the normal animals. Following the production of mitral insufficiency, characteristic alterations of the esophageal pulse wave contour were observed. These very closely paralleled the pressure tracings obtained simultaneously within the left atrium itself.It was also possible to detect a fall of the regurgitation pressure which resulted from hemorrhage or a rise which was produced by aortic compression. A ratio of approximately 3 to 1 was observed between simultaneously recorded atrial and esophageal pulse pressures in the dogs with mitral insufficiency.It is suggested that the contour of the pulse waves of the esophagus at the level of the left atrium, recorded with this technic, closel...
The Gender Problem of Buddhist Nationalism in Myanmar: The 969 Movement and Theravada Nuns

Part of the Asian History Commons, Asian Studies Commons, Buddhist Studies Commons, Community-based Research Commons, Ethics in Religion Commons, Ethnic Studies Commons, Gender and Sexuality Commons, History of Religion Commons, Inequality and Stratification Commons, International Relations Commons, New Religious Movements Commons, Other Feminist, Gender, and Sexuality Studies Commons, Politics and Social Change Commons, Race and Ethnicity Commons, Social and Cultural Anthropology Commons, Sociology of Religion Commons, and the Women's Studies Commons
Posttranslational Regulation of Organic Anion Transporters by Ubiquitination: Known and Novel.

Organic anion transporters (OATs) encoded by solute carrier 22 family are localized in the epithelia of multiple organs, where they mediate the absorption, distribution, and excretion of a diverse array of negatively charged environmental toxins and clinically important drugs. Alterations in the expression and function of OATs play important roles in intra- and interindividual variability of the therapeutic efficacy and the toxicity of many drugs. As a result, the activity of OATs must be under tight regulation so as to carry out their normal functions. The regulation of OAT transport activity in response to various stimuli can occur at several levels such as transcription, translation, and posttranslational modification. Posttranslational regulation is of particular interest, because it usually happens within a very short period of time (minutes to hours) when the body has to deal with rapidly changing amounts of substances as a consequence of variable intake of drugs, fluids, or meals as well as metabolic activity. This review article highlights the recent advances from our laboratory in uncovering several posttranslational mechanisms underlying OAT regulation. These advances offer the promise of identifying targets for novel strategies that will maximize therapeutic efficacy in drug development.
After The Haze: Legal Aspects of Hazing

Hazing continues to be legally problematic for institutions. In June 2007, a New Jersey prosecutor brought criminal charges against two administrators over the alcohol-related death of a freshman. It is not uncommon for administrators to be charged civilly in hazing cases, but this is believed to be the first time college administrators have been charged criminally in a hazing incident. Although the case against the administrators was dropped, the charges indicate that administrators may run the risk of being charged in both civil and criminal courts. It is therefore important for institutional administrators to have an understanding of hazing, its laws and its effects on their institutions. Institutions looking to be proactive by creating programs to diminish hazing may be held to a higher legal duty of care. This conundrum clouds the hazing problem further for administrators. In this article, possible legal issues and implications for institutions will be explored through a review of literature and case law.
Relationship between depression, self-care behaviors, and treatment success among older Medicare beneficiaries with type 2 diabetes

Objective Comorbid depression among patients with diabetes is associated with an increased disease burden, healthcare utilization and adverse outcomes. However, little is known about how comorbid depression in older adults with diabetes affects diabetes treatment success. This study investigates the association between comorbid depression, diabetes-related self-care behaviors and blood glucose control among older Medicare beneficiaries with type 2 diabetes. Methods This pooled cross-sectional study used the Medicare Current Beneficiary Survey (MCBS) data for years 2006, 2008 and 2010. Depression was categorized into mild/episodic and moderate/severe. We defined levels of treatment success based on gradients of blood glucose control: all the time to little/none of the time. We used ordered-logit regression models for analyses. Key findings Among the study population of older Medicare beneficiaries with diabetes (n = 2418), 6.2% had episodic/mild depression and 7.9% had moderate/severe depression. Low frequency of performing self-check for blood glucose or sores on feet was not associated with either mild/episodic depression (OR = 0.92; 95% CI, 0.64 to 1.33)/(OR = 0.98; CI, 0.69 to 1.39) or moderate/severe depression (OR = 1.18; 95% CI, 0.83 to 1.66)/(OR = 0.98; 95% CI, 0.7 to 1.4) respectively. Patients with mild/episodic depression were more likely to reach blood glucose control little/none of the time, as compared to those with no comorbid depression (OR = 1.62; 95% CI, 1.17 to 2.26). Conclusions Comorbid mild/episodic depression is associated with low treatment success among older Medicare beneficiaries with diabetes; however, neither levels of comorbid depression are associated with regularity in performing self-care behavior.
Regional Development Banks in Comparison: Banking Strategies versus Development Goals

In a study that contributes to international relations and international political economy theory, Ruth Ben-Artzi raises substantive issues relating to aid, development, international relations and globalization. Regional development banks (RDBs), designed by politicians and economists to maneuver through labyrinths of economic, social, and political development, possess the potential to be central players in the long-term planning involved in healing and advancing poverty-plagued regions. However, RDBs in particular have received little attention. With a systematic analysis comparing four central regional development banks, this book explores why there is a variation in strategy despite similar institutional design. The formal arrangements and raison d'etre of RDBs is to assist developing countries in the process of poverty alleviation - a task that is often a risky investment. Focusing on the dichotomy between their banking and development roles, Ben-Artzi demonstrates that RDBs are potentially critical catalysts in the fight against poverty, even with their institutional limitations.
Cutaneous adnexal adenocarcinoma with exquisite sensitivity to trastuzumab

BACKGROUND Cutaneous adnexal adenocarcinoma is a rare cancer that is occasionally human epidermal growth factor receptor-2 (HER-2)-positive, and demonstrates variable response to HER-2 inhibitors. METHODS We report a case of adnexal adenocarcinoma of the scalp in a 56-year-old man. He underwent wide local excision with cervical node dissection followed by radiation, but had extensive local recurrence. RESULTS Pathology demonstrated a poorly differentiated adnexal adenocarcinoma with HER-2 overexpression by immunohistochemistry (IHC) and high HER-2 gene amplification by fluorescence in situ hybridization. The patient was treated with trastuzumab-based therapy with dramatic response and clinical resolution of the tumor. Upon pausing trastuzumab, he developed local relapse, but had an excellent response to restarting trastuzumab monotherapy. He lacks visible disease 43 months after the initial diagnosis. CONCLUSION We believe the exquisite sensitivity of the primary carcinoma and subsequent recurrence to trastuzumab therapy was due to strong HER-2 expression both at the protein and gene level. © 2017 Wiley Periodicals, Inc. Head Neck 39: E69-E71, 2017.
Role of de‐N‐acetylase PgaB from Aggregatibacter actinomycetemcomitans in exopolysaccharide export in biofilm mode of growth

Summary Aggregatibacter actinomycetemcomitans, a Gram-negative bacterium, is the causative agent of localized aggressive periodontitis. Attachment to a biotic surface is a critical first step in the A. actinomycetemcomitans infection process for which exopolysaccharides have been shown to be essential. In addition, the pga operon, containing genes encoding for biosynthetic proteins for poly-N-acetyl glucosamine (PNAG), plays a key role in A. actinomycetemcomitans virulence, as a mutant strain lacking the pga operon induces significantly less bone resorption. Among the genes in the pga operon, pgaB codes for a de-N-acetylase that is responsible for the deacetylation of the PNAG exopolysaccharide. Here we report the role of PgaB in regulation of virulence genes using a markerless, scarless deletion mutant targeting the coding region of the N-terminal catalytic domain of PgaB. The results demonstrate that the N-terminal, catalytic domain of PgaB is crucial for exopolysaccharide export. This article is protected by copyright. All rights reserved.
Clinical high-resolution mapping of the proteoglycan-bound water fraction in articular cartilage of the human knee joint

Abstract Purpose We applied our recently introduced Bayesian analytic method to achieve clinically-feasible in-vivo mapping of the proteoglycan water fraction (PgWF) of human knee cartilage with improved spatial resolution and stability as compared to existing methods. Materials and methods Multicomponent driven equilibrium single-pulse observation of T 1 and T 2 (mcDESPOT) datasets were acquired from the knees of two healthy young subjects and one older subject with previous knee injury. Each dataset was processed using Bayesian Monte Carlo (BMC) analysis incorporating a two-component tissue model. We assessed the performance and reproducibility of BMC and of the conventional analysis of stochastic region contraction (SRC) in the estimation of PgWF. Stability of the BMC analysis of PgWF was tested by comparing independent high-resolution (HR) datasets from each of the two young subjects. Results Unlike SRC, the BMC-derived maps from the two HR datasets were essentially identical. Furthermore, SRC maps showed substantial random variation in estimated PgWF, and mean values that differed from those obtained using BMC. In addition, PgWF maps derived from conventional low-resolution (LR) datasets exhibited partial volume and magnetic susceptibility effects. These artifacts were absent in HR PgWF images. Finally, our analysis showed regional variation in PgWF estimates, and substantially higher values in the younger subjects as compared to the older subject. Conclusions BMC-mcDESPOT permits HR in-vivo mapping of PgWF in human knee cartilage in a clinically-feasible acquisition time. HR mapping reduces the impact of partial volume and magnetic susceptibility artifacts compared to LR mapping. Finally, BMC-mcDESPOT demonstrated excellent reproducibility in the determination of PgWF.
CDK4 is an important target for hepatocellular cancer with inactivation of TGF-beta signaling through Smad and ELF

2583 Background: Transforming growth factor (TGF-β) signaling inhibits cell cycle progression through an increase in cell cycle inhibitors and decrease in cell cycle activators. We have shown that the Smad3/4 adaptor protein embryonic liver fodrin (ELF) is crucial for normal TGF-β signaling. ELF facilitates the association and nuclear translocation of the TGF-β signaling proteins, Smad3 and Smad4. Our results demonstrate that elf +/- /CDK4 +/+ mice develop hepatocellular cancers (HCC) spontaneously within 12 months. Our results also show that most human HCCs exhibit decreased expression of ELF and a concomitant increase in the expression of Cyclin D1 and CDK4. Interestingly, Smad3 is a CDK4 substrate, yet Smad3 mice mostly do not develop tumors. Our hypothesis is that ELF is a potential CDK4 substrate Methods and Results: To further assess whether the development of HCC in elf +/- /CDK4 +/+ mice is dependent upon CDK4 expression, we intercrossed elf +/- /CDK4 +/+ and elf +/+ /CDK4 +/- mice. To date, only 5% (1/20) of the elf +/- /CDK4 +/- mice developed HCC. Specifically, at 12 months, only 1/10 (10%) of the elf +/- /CDK4 +/- mice developed HCC, compared to 25% of age matched elf +/- /CDK4 +/+ mice based on our historical controls. More impressively, 0/10 of the 18 month old elf +/- /CDK4 +/- mice developed HCC, compared with nearly 50% of age matched elf +/- /CDK4 +/+ mice based on our historical controls. These data correspond to a median disease free survival of >3 years in the elf +/- /CDK4 +/- mice compared with only 18 months in the elf +/- /CDK4 +/+ mice. ELF and CDK4 interact endogenously as well as in vitro. ELF is also phosphorylated by CDK4. Moreover, ELF, CDK4, and Smad3 complex together through an interaction that is likely mediated by the N-terminal domain of ELF. Conclusions: These data strongly suggest that haploinsufficiency of CDK4 can prevent the HCCs seen in elf +/- /CDK4 +/+ mice, and provides the genetic foundation for further exploring the benefits of specific inhibitors of CDK4 in the treatment of HCC. These results demonstrate that haploinsufficiency of CDK4 prevents the formation of HCC, and thus targeted-inhibition of CDK4 activity may be a logical treatment for HCC in humans interaction with CDK4.
Sport, Trust, and Social Capital

Research in social capital has appealed to the causal power of sport to generate the kinds of generalized trust, ties, and networks that make for more prosperous communities and more democratic societies. Indeed, Robert Putnam’s Bowling Alone (2001) takes as the core of its argument the idea that participation in bowling clubs in the United States contributed, in no small way, to ‘making democracy work’ in America. In this way sport appears to be construed as a mechanism for the production of generalized trust and, more broadly, social capital. This study scrutinizes Putnam’s understanding of sport in an effort to make explicit the limits of what participation in sport can be expected to contribute to the formation of generalized trust and social capital. In the context of sport, generalized trust and social capital, the author argues, are best understood in theoretical and empirical terms as stratified and stratifying features of human interaction. Sport does not produce generalized trust and social capital but rather re-produces and reinforces the presence of such resources along socioeconomic and ethnoracial lines.
Latinoamericanismo, Barroco de Indias y colonialidad del poder: reflexiones sobre políticas de exclusión

Este ensayo examina los debates y las relecturas a proposito del llamado Barroco de Indias que se han originado en el ambito de los estudios latinoamericanos en las ultimas decadas. Se enfoca en los estudios sobre el escritor peruano Juan Espinosa Medrano C1629?-1688, llamado el "Lunarejo", y problematiza los postulados que claman ver en el barroco y en sus representantes literarios, los primeros procesos de definicion de una identidad y modernidad "americana" propias. El autor considera que estas lecturas, a pesar de que buscan responder a interpretaciones colonialistas, rearticulan un proyecto latinoamericanista que excluye las conflictivas relaciones etnico-culturales entre indigenas y no indigenas, asi como tambien refuerza lo que Anibal Quijano y Walter Mignolo llaman la colonialidad del poder.
The Near-Irrelevance of Sampling Frequency Distributions

Jaynes, in his unfinished work on probability theory [2], discusses the Gaussian distribution extensively. In that discussion he demonstrates that when using a Gaussian distribution to estimate a location parameter, the only properties of the noise that enter the calculation are the first and second moments of the true noise; the underlying ensemble sampling distribution for the noise, the distribution from which the noise was actually sampled, completely cancels out of the inference. Exactly the same inferences will be made regardless of the underlying ensemble sampling distribution for the noise, provided the first and second moments of the true noise are the same. In this paper we review Jaynes’ calculation, demonstrate it explicitly, generalize it to more complex models, and show that for regression style models the underlying ensemble sampling distribution for the noise is irrelevant to our inferences provided the mean and mean-square projection of the model onto the true noise are the same.
Semantic interpretation based on the multi-world model

This paper proposes the Multi-World Model as a new logical framework for semantic interpretation of natural language. The model represents worlds as first-order axiomatic systems linked through interpretations between worlds, which are mappings of theorems between these axiomatic systems. Results of semantic interpretation are assumed to be constructed on such a multi-world structure. To understand ambiguous sentences, people make assumptions to complement information that is unknown to them. If an assumption is consistent with information that is known to them, then they will support that assumption and make a unique interpretation of the sentence. When a new sentence comes in whose interpretation conflicts with a previous interpretation, they will consider another assumption. When the context is fixed, the whole interpretation will be decided by selecting the most, preferable assumptions. The Multi-World Model was designed as a formal description of facts, assumptions, background knowledge, and their relationships. This paper defines the Multi-World Model and presents its application to semantic interpretation with concrete examples.
Effect of Spectral Degradation and Spatio-Energy Correlation in X-Ray PCD for Imaging

Charge sharing, scatter, and fluorescence events in a photon counting detector can result in counting of a single incident photon in multiple neighboring pixels, each at a fraction of the true energy. This causes energy distortion and correlation of data across energy bins in neighboring pixels (spatio-energy correlation), with the severity depending on the detector pixel size and detector material. If a “macro-pixel” is formed by combining the counts from multiple adjacent small pixels, it will exhibit correlations across its energy bins. Understanding these effects can be crucial for detector design and for model-based imaging applications. This paper investigates the impact of these effects in basis material and effective monoenergetic estimates using the Cramer-Rao Lower Bound. To do so, we derive a correlation model for the multi-counting events. CdTe detectors with grids of pixels with side length of $250~\mu \text{m}$ , $500~\mu \text{m}$ , and 1 mm were compared, with binning of $4\times4$ , $2\times2$ , and $1\times1$ pixels, respectively, to keep the same net 1 mm2 aperture constant. The same flux was applied to each. The mean and covariance matrix of measured photon counts were derived analytically using spatio-energy response functions precomputed from Monte Carlo simulations. Our results show that a 1 mm2 macro-pixel with $250\times 250\,\,\mu \text{m}^{\textsf {2}}$ sub-pixels shows 35% higher standard deviation than a single 1 mm2 pixel for material-specific imaging, while the penalty for effective monoenergetic imaging is $^{\textsf {2}}$ pixel. Potential benefits of sub-pixels (higher spatial resolution and lower pulse pile-up effects) are important but were not investigated here.
SOD1 phosphorylation by mTORC1 integrates nutrient sensing and redox regulation in normal physiology and cancer

Nutrients are not only organic compounds fueling bioenergetics and biosynthesis, but also key chemical signals controlling growth and metabolism. Nutrients enormously impact the production of reactive oxygen species (ROS), which play essential roles in normal physiology and diseases. How nutrient signaling is integrated with redox regulation is an interesting but not fully understood question. Herein, we report that superoxide dismutase 1 (SOD1) is a conserved component of the mechanistic target of rapamycin complex 1 (mTORC1) nutrient signaling. mTORC1 regulates SOD1 activity through reversible phosphorylation at S39 in yeast and T40 in humans in response to nutrients, which moderates ROS level and prevents oxidative DNA damage. We further show that SOD1 activation enhances cancer cell survival and tumor formation in the ischemic tumor microenvironment, and protects against the chemotherapeutic agent cisplatin. Collectively, these findings identify a conserved mechanism by which eukaryotes dynamically regulate redox homeostasis in response to changing nutrient conditions, which is important for normal physiology and cancer.
Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL)

The QT interval is an important diagnostic feature on surface electrocardiograms because it reflects the duration of the ventricular action potential. A previous genome-wide association study has reported a significant linkage between a single-nucleotide polymorphism ∼11.7 kb downstream of the gene encoding the RING finger ubiquitin ligase rififylin (RFFL) and variability in the QT interval. This, along with results in animal studies, suggests that RFFL may have effects on cardiac repolarization. Here, we sought to determine the role of RFFL in cardiac electrophysiology. Adult rabbit cardiomyocytes with adenovirus-expressed RFFL exhibited reduced rapid delayed rectifier current (IKr). Neonatal rabbit cardiomyocytes transduced with RFFL-expressing adenovirus exhibited reduced total expression of the potassium channel ether-a-go-go-related gene (rbERG). Using transfections of 293A cells and Western blotting experiments, we observed that RFFL and the core-glycosylated form of the human ether-a-go-go-related gene (hERG) potassium channel interact. Furthermore, RFFL overexpression led to increased polyubiquitination and proteasomal degradation of hERG protein and to an almost complete disappearance of IKr, which depended on the intact RING domain of RFFL. Blocking the ER-associated degradation (ERAD) pathway with a dominant-negative form of the ERAD core component, valosin-containing protein (VCP), in 293A cells partially abolished RFFL-mediated hERG degradation. We further substantiated the link between RFFL and ERAD by showing an interaction between RFFL and VCP in vitro. We conclude that RFFL is an important regulator of voltage-gated hERG potassium channel activity and therefore cardiac repolarization and that this ubiquitination-mediated regulation requires parts of the ERAD pathway.
Ethics, Transparency, and Public Health at the Intersection of Innovation and Facebook's Suicide Prevention Efforts.

Artificial intelligence and machine learning promise to improve health care and health itself, but potential pitfalls exist. A recent example is Facebook's efforts to screen posts to identify users...
A Mulching Proposal: Analysing and Improving an Algorithmic System for Turning the Elderly into High-Nutrient Slurry

The ethical implications of algorithmic systems have been much discussed in both HCI and the broader community of those interested in technology design, development and policy. In this paper, we explore the application of one prominent ethical framework-Fairness, Accountability, and Transparency-to a proposed algorithm that resolves various societal issues around food security and population ageing. Using various standardised forms of algorithmic audit and evaluation, we drastically increase the algorithm's adherence to the FAT framework, resulting in a more ethical and beneficent system. We discuss how this might serve as a guide to other researchers or practitioners looking to ensure better ethical outcomes from algorithmic systems in their line of work.
Testing an optimization–simulation model for optimal pump and valve operations with required storage tank turnovers

An optimization–simulation model is developed for the operation of pumps and valves in water distribution systems (WDS) requiring storage tank turnover. …
Restless Epitaphs: Revenance and Dramatic Tension in Bob Dylan’s Early Narratives

Damian A. Carpenter’s chapter explores “two ways in which Dylan makes use of epitaph in his work and what this use symbolizes in regard to his identity as an artist: (1) as a performative, dramatic rhetorical space and (2) as an existential threat.” Carpenter engages Dylan’s debts to traditional poetics while also insisting upon (and stressing the importance of) his unique role as a writer of songs/music. Carpenter deploys an intriguing idea of “revenance,” defined in this context as “a portmanteau term that encompasses notions of the revenant (in terms of both a ghostly presence and simply meaning one who returns to a place), resonance and presence.” Central to his analysis is Dylan’s tendency to embrace a social/aesthetic past he simultaneously seeks to overcome.
A mouse model of renal ischemia-reperfusion injury solely induced by cold ischemia

Transplanted kidneys usually experience several episodes of ischemia, including cold ischemia during allograft storage in preservation solution. However, previous studies focusing on cold renal isc...
Intraorganizational conditions for social innovation in sport for development and peace

Research question: What are the intraorganizational conditions necessary for social innovation in Sport for Development and Peace (SDP)?Research methods: Data were collected via semi-structured int...
Enhancing die level static fault isolation on power gated devices

Abstract Modern SoC design incorporates power management circuits to minimize standby leakages of digital logic circuitry. This isolates the logic blocks from being directly powered by the IC's pad level power supply and ground. As a result, die level static fault isolation became ineffective even for gross defects that are shorting the power lines in the logic blocks due to gated supply. From the foundry standpoint, fault isolation on such devices are even more challenging without the product knowhow, device specific hardware and test program to properly condition the power management circuits. An alternative method is to bypass the power control circuits through microprobing on the top metal traces to directly supply power to the logic blocks. However, the key challenge to this method is the means to differentiate between power gated and non-gated devices and then subsequently verify the relevant power traces to microprobe especially in the absence of layout. This paper illustrates 4 different approaches to overcome this challenge and achieve static fault isolation success on power gated devices. Successful applications of this approach to localize gross defects resulting in short/leakage failures and subtle defects resulting in memory/logic functional failures will be described.
Management of nonpainful supernumerary phantom limbs after incomplete spinal cord injury with visual-tactile feedback therapy: a case report.

INTRODUCTION Supernumerary phantom limb (SPL) is an uncommon phantom sensation where the patient experiences the illusory presence of one or more limbs in addition to their existing limbs. SPL after a spinal cord injury (SCI) is rare with few documented cases. There is minimal treatment guidance available, with some reports of visual-tactile feedback therapy used to manage SPL. CASE PRESENTATION A 43-year-old male sustained a C4 ASIA Impairment Scale grade C SCI, developing the sensation of two SPL arms originating from his shoulders 6 days after injury. He developed a self-directed method of visual-tactile feedback as a means to improve the SPL sensations, consisting of shrugging his shoulders repeatedly for 1 min while observing the movement of his actual arms. After completion of this routine, the SPL moved to the same location as his arms, providing relief. Also, an elastic band was placed on a sensate region of his arm, providing additional visual-tactile feedback. The SPL improved and resolved by day 45. DISCUSSION SPL after SCI is poorly characterized, usually occurring within 6-7 days of injury after a complete or incomplete cervical SCI. While the mechanism is unclear, the inability to integrate visual, tactile, and proprioceptive information after deafferentation may contribute to development. Similarities between SPL and phantom limb sensation after an amputation have resulted in the use of visual and visual-tactile feedback therapy for painful SPL management. This is the first case documenting successful use of visual-tactile feedback therapy to manage nonpainful SPL.
Reliable Least-Time Path Estimation and Computation in Stochastic Time-Varying Networks with Spatio-Temporal Dependencies

This paper studies the problem of estimation and computation of reliable least-time paths in stochastic time-varying (STV) networks with spatio-temporal dependencies. For a given desired confidence level $\alpha$, the least-time paths from any origin to a given destination node are to be found over a desired planning horizon. In STV networks, least-time path finding approaches aim to incorporate an element of reliability to help travelers better plan their trips to prepare for the risk of arriving later or traveling for longer than desired. A label-correcting algorithm that incorporates time-dependence of the travel time distributions is proposed. The algorithm incorporates a Monte Carlo sampling approach for a path travel time estimation with time-dependence, which can also be used as an approximate solution method with spatial link travel-time correlations. Numerical results on the large-scale Chicago network are provided to test for the performance of the algorithms and the robustness of solutions. The trade-off between accuracy and efficiency of the approximate solution method compared to a Monte Carlo simulation-based approach is discussed and evaluated.
The Genius of the Zebrafish Model: Insights on Development and Disease.

The zebrafish is an outstanding and inexpensive vertebrate model system for biomedical research [...]
On the development of methods for assessing project financing risks

The introduction of new methods for industrial infrastructural development and the methods of financing has led to the emergence of a promising direction - project financing. The development of project financing in the Russian Federation is primarily associated with a change in legislation, within the framework of which a system of escrow accounts was introduced in order to preserve the funds of equity holders. The gradual transition from the traditional equity participation scheme to project financing should contribute to the development of the construction industry, increased business activity and an increase in construction volumes. However, the limiting factor in the development of this area is the high risks for all participants in the investment and construction process and the lack of an effective method for assessing the risks of project financing. The development of this method is complicated by the fact that along with the general and characteristic risks of all investment projects, each project has its own characteristics, specific contractual and financial structure and implementation conditions and is associated with industry and regional risks inherent in this particular project. In this regard, the development of methods for assessing the project financing risks is one of the tools for making timely management decisions on the part of the developer to optimize the investment and construction process. This will allow attracting additional resources to the investment and construction sector and increasing the volume of housing construction.
Alzheimer's Disease And Frontotemporal Dementia Exhibit Distinct Atrophy-Behavior Correlates:

Rationale and Objectives. The purpose of this study was to test the hypothesis that distinct patterns of gray matter atrophy are responsible for unique interruptions of the naming process in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Materials and Methods. Voxel-based morphometry (VBM) was performed to characterize at the voxel level the neuroanatomic changes that occur in AD and FTD based on high-resolution T1-weighted three-dimensional (3D) spoiled-gradient echo images of patients (AD, n 12; FTD, n 29) and healthy control subjects (n 12). The cortical atrophy measurements were correlated with performance on behavioral measures of naming and related processes to identify brain regions that may contribute to this language function. Results. Both AD and FTD have significant naming difficulty, and this difficulty in naming correlates with a measure of lexical retrieval in both patient groups as well. However, only FTD patients showed a correlation with semantic memory. Areas of cortical atrophy common to AD and FTD were found in the anterior temporal, posterolateral temporal, and dorsolateral prefrontal regions of the left hemisphere. Correlation with naming in both AD and FTD was seen in the left anterior temporal cortex, suggesting that this area may play a role in the lexical retrieval component of naming. We also observed several unique areas of cortical atrophy in temporal and frontal cortices of these patients. Right anterior temporal and left posterolateral temporal regions of atrophy correlated with naming difficulty in FTD, suggesting that these areas may contribute to the semantic memory component of naming. Cortical areas correlating with naming that are not atrophic may represent regions that play an optional role in naming. Conclusion. VBM provides an important first step in analyzing brain– behavior relations in vivo in patients with neurodegenerative diseases. More refined analyses of brain morphology via high-dimensional normalization methods that are capable of modeling local as well as global variability in neuroanatomical structure promise to be even more informative.
Dynamic linkages between vegetation phenology and seasonal changes in water quality in the Choptank watershed, USA

One of the greatest challenges in water-quality management is to understand the many complex interactions between landscape structure and nutrient transport. This study analysed the relationship between the inter-annual vegetation phenologies and seasonal change of water quality in the Choptank Basin, a typical agricultural tributary of the Chesapeake Bay along the east coast of USA, using blended images from Landsat Thematic Mapper and Moderate Resolution Imaging Spectroradiometer. Cross-Correlogram Spectral Matching CCSM was applied to explain the correlation between seasonal nitrate discharge and phenologies of different crop types as well as forest. Nitrate discharges from forest-dominated watersheds are reduced as the forest greens up with an increasing percentage above the predefined enhanced vegetation index EVI threshold values. The crop-dominant watersheds have higher correlations than the forest-dominant watersheds between seasonal nitrate discharge and vegetation phenologies. The correlations between seasonal water quality and vegetation phenology in forest-dominant watershed have less variance than those of crop-dominant watersheds. The highest correlations were found between EVI and water quality at one or two months ‘later’, e.g. between the ‘earlier’ green-up and the ‘later’ nutrient discharge. This work could be applied to guide farmland planning to effectively control the non-point source pollution.
Maximum SINR beamforming for correlated sources

We consider the signal-to-interference plus noise ratio (SINR) performance of several beamforming algorithms, taking particular account of the contribution of sources correlated with the desired signal. In addition, we derive an optimal method that maximizes SINR by combining with the desired signal estimate any components of the interference/multipaths that are correlated with it. To facilitate performance comparisons, we only consider the case where the signal directions of arrival (DOAs) are precisely known. The extension to unknown DOAs is straight-forward. Our analysis includes the first order effects of array calibration errors, and is verified by numerical simulation.
Evaluation of Anterior Extra Vesical Ureteroneocystostomy in Kidney Transplantation

Abstract We evaluated the anterior extravesical ureteroneocystostomy technique in 184 consecutive renal transplants done in 2 consecutive calendar years. Complications included 5 cases of ureteral and 1 of pelvic necrosis, and 2 of ureteral obstruction, with a ureteral complication rate of The extraordinary simplicity of this technique, coupled with improvement in the complication rate, makes it our procedure of choice.
Hierarchical optimization strategies for sensor network deployment

The objective of this research is to develop a new hierarchical design framework for balanced coordinated algorithms addressing sensor network deployment problems in network systems as a means to enhance dissemination of network resources so that optimal responses to network damages and threats by the weapons of mass destruction (WMD) will be achieved and recovery of the network can be significantly improved. In particular, this research will involve a two-stage hierarchical algorithm design in which the first stage is a network topology design for cascaded resilience in the network while the second stage is an optimal weight design for network graphs characterizing efficiency based on the graph topology obtained in the first stage. We convert the first stage design into a multi-objective optimization problem and the second stage design into a constrained optimization problem. To solve both proposed optimization problems, we develop a modified particle swarm optimization (PSO) based stochastic algorithm to approximate optimal solutions of the multi-objective optimization problem and a semistable optimal control approach to solve the constrained optimization problem. The overall method combines control theory, distributed algorithms, and optimization together to improve network resource allocation and damage mitigation under WMD attacks and other adversary conditions.
Public Participation in Analytic-Deliberative Decision Making: Evaluating a Large-Group Online Field Experiment

This article reports an evaluation of the quality and scale of interactions during an online field experiment. A large number of individuals (n= 179) worked with an online public participation geographic information system (PPGIS) platform during a month-long field experiment about regional transportation improvement decision making in the central Puget Sound area of Washington. The system platform logged more than 120,000 client–server interaction events. We developed a geovisual analytic technique called a grapevine to evaluate the quality and scale of public participation using event log data. The grapevine 4D space–time geographic information system (GIS) visualization helps distinguish productive clusters of analytic-deliberative process and for guiding content analysis of the user-generated discussion. Comparison of the nature and content of participant message exchanges before and after GIS-based analytic activities revealed a significant shift in focus. We characterize this shift in the focus of d...
Newer Methods for Characterization of Antibiotics I: Stable Isotopes in the Study of Antibiotic Synthesis

Precursors singly and doubly labeled with stable isotopes can be used to study both the origins of antibiotic molecules and the mechanisms involved in their biosyntheses. In this review, the versatile methodology used for these approaches is discussed, using examples from the biosynthetic investigations of neomycin, ribostamycin, nybomycin and erythromycin and of two antibiotics containing the so–called m–C7N unit, pactamycin and gel–danamycin. *The E. R. Squibb Lectures on Chemistry of Microbial Products presented at Waksman Institute of Microbiology, Rutgers University, New Brunswick, N.J. March 16, 17, 1983.
Evaluation of high intensity focused ultrasound ablation of prostate tumor with hyperpolarized 13C imaging biomarkers

Real-time hyperpolarized (HP) 13 C MR can be utilized during high-intensity focal ultrasound (HIFU) therapy to improve treatment delivery strategies, provide treatment verification, and thus reduce the need for more radical therapies for lowand intermediate-risk prostate cancers. The goal is to develop imaging biomarkers specific to thermal therapies of prostate cancer using HIFU, and to predict the success of thermal coagulation and identify tissues potentially sensitized to adjuvant treatment by sub-ablative hyperthermic heat doses. Mice with solid prostate tumors received HIFU treatment (5.6 MHz, 160W/cm 2 , 60 s), and the MR imaging follow-ups were performed on a wide-bore 14T microimaging system. 13 C-labeled pyruvate and urea were used to monitor tumor metabolism and perfusion accordingly. After treatment, the ablated tumor tissue had a loss in metabolism and perfusion. In the regions receiving sub-ablative heat dose, a timedependent change in metabolism and perfusion was observed. The untreated regions behaved as a normal untreated TRAMP prostate tumor would. This promising preliminary study shows the potential of using 13 C MR imaging as biomarkers of HIFU/thermal therapies.
Leukocyte reduction and HTLV-I: is the glass half empty or half full?

We read with interest the recent article by Pennington et al.[1][1] Based on the ability to detect Tax DNA in the blood of asymptomatic carriers with proviral loads exceeding 108 DNA copies/L, the authors conclude that leukocyte depletion (LD) may not provide complete protection from human T-cell
On the importance of dimensionality of space in models of space-mediated population persistence

Spatially explicit models have become widely used in today's mathematical ecology to study persistence of populations. For the sake of simplicity, population dynamics is often analyzed with 1-D models. An important question is: how adequate is such 1-D simplification of 2-D (or 3-D) dynamics for predicting species persistence. Here we show that dimensionality of the environment can play a critical role in the persistence of predator-prey interactions. We consider 1-D and 2-D dynamics of a predator-prey model with the prey growth damped by the Allee effect. We show that adding a second space coordinate into the 1-D model results in a pronounced increase of size of the domain in the parametric space where predator-prey coexistence becomes possible. This result is due to the possibility of formation of a number of 2-D patterns, which is impossible in the 1-D model. The 1-D and the 2-D models exhibit different qualitative responses to variations of system parameters. We show that in ecosystems having a narrow width (e.g. mountain valleys, vegetation patterns along canals in dry areas, etc.), extinction of species is more probable compared to ecosystems having a pronounced second dimension. In particular, the width of a long narrow natural reserve should be large enough to guarantee nonextinction of species via interaction of 2-D population patches.
Communication disturbances in the natural speech of schizophrenic patients and non-schizophrenic parents of Patients

Subclinical communication disturbances in the relatives of schizophrenic patients appear to be heterogeneous in both form and origin. The Communication Disturbances Index (CDI) was applied to the natural speech of stable schizophrenic out patients, non-schizophrenic parents of patients, and control subjects. The parents of schizophrenic patients displayed more frequent overall instances of communication failure in their speech than the controls. The specific types of disturbance that were more frequent were structural lack of clarity, vague references and ambiguous word meanings. The parents did not differ significantly from the patients with regard to total CDI ratings. However, patients made more frequent missing-information references than parents, and parents made more frequent vague references than patients. High CDI scores in parents were associated with more severe lifetime core positive symptoms in their patient offspring.
627 THE EFFECT OF DIFFERENT CALCIUM AND PHOSPHORUS CONTENT ON GROWTH AND BONE MINERALIZATION IN PRETERM INFANTS

627 THE EFFECT OF DIFFERENT CALCIUM AND PHOSPHORUS CONTENT ON GROWTH AND BONE MINERALIZATION IN PRETERM INFANTS
The use of specific macromolecular complexing agents for enzyme purification: Beef heart dehydregenase

The use of specific insoluble absorbants as adjuncts for the purification of antibodies (1), enzymes (2), and ribonucleic acids (3) has been demonstrated. The basic approach has been to link a water-insoluble polymer (polystyrene, cellulose, etc.) covalently to a specific molecule (substrate, competitive inhibitor or antigen) which will form a complex with the substance (enzyme, antibody, etc.) being purified in a subsequent column chromatographic procedure. The studies reported here are concerned with the utilization of a specific soluble macromolecular complexing agent in the purification of beef heart lactic dehydrogenase (BH-LDH). The complexing agent (BSA-I) is bovine serum albumin linked covalently to oxanylic acid, which is a competitive inhibitor for the binding of substrate to the active site of the enzyme. The complexing agent (BSA-I) was found to specifically alter the solubility of BH-LDH in ammonium sulfate solution, and the formation of the complex was also shown to be NAD+ dependent.