cssi/SciSciGPT-SciSciNet huggingface dataset:
Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat

The parabrachial complex, also known as the pneumotaxic center or pontine respiratory group, has long been recognized as an important participant in respiratory control. One line of evidence supporting this idea is the demonstration of changes in breathing pattern following injection of neuroactive substances into or near the parabrachial complex. However, it is not yet known exactly which cell groups and projections mediate those responses. In order to address this issue, we explored the topographic organization of respiratory responses to chemical stimulation of the parabrachial complex of the rat and examined the descending projections of the most sensitive sites. Injection of glutamate (5–100 pmol) at specific sites in or near the parabrachial nucleus produced three distinct site-specific response patterns. First, hyperpnea followed glutamate injection into far rostral and midcaudal areas of the Kolliker-Fuse nucleus and most of the lateral parabrachial nucleus, including the external lateral, central lateral, dorsal lateral, and superior lateral subnuclei. Threshold hyperpneic effects were manifested as single, deepened breaths of premature onset. Suprathreshold doses of glutamate at these locations produced tachypnea. Neurons in these sites projected to the ventral respiratory group in the ventrolateral medulla. Second, the most intense inspiratory facilitatory responses were seen at mid to rostral levels of the Kolliker-Fuse nucleus, near the ventrolateral tip of the superior cerebellar peduncle. Even at threshold doses of glutamate, exhalation was incomplete, resulting in a breathing pattern that resembled apneusis (an inspiratory cramp). This site contained an especially dense cluster of neurons that projected either to the ventrolateral medulla or to the dorsal respiratory group in the nucleus of the solitary tract, but not to both areas. The third type of response, decreases in respiratory rate, occurred following glutamate injection at the most lateral and ventral boundaries of the Kolliker- Fuse nucleus. The most sensitive apneic sites were not found in the parabrachial nucleus but along the dorsal and medial edge of the principal sensory trigeminal nucleus and extending ventrally between the sensory and motor trigeminal nuclei. Scattered neurons in these sites were retrogradely labeled from the ventral but not the dorsal respiratory group. These results indicate that there are anatomically and functionally distinct cell populations in and near the parabrachial complex that, when chemically stimulated, can produce specific and sometimes opposing effects on respiration. The predominant effect of lateral parabrachial stimulation is respiratory facilitation, while inhibitory effects are elicited by trigeminal injections of glutamate.
A d-statistic for single-case designs that is equivalent to the usual between-groups d-statistic

We describe a standardised mean difference statistic (d) for single-case designs that is equivalent to the usual d in between-groups experiments. We show how it can be used to summarise treatment effects over cases within a study, to do power analyses in planning new studies and grant proposals, and to meta-analyse effects across studies of the same question. We discuss limitations of this d-statistic, and possible remedies to them. Even so, this d-statistic is better founded statistically than other effect size measures for single-case design, and unlike many general linear model approaches such as multilevel modelling or generalised additive models, it produces a standardised effect size that can be integrated over studies with different outcome measures. SPSS macros for both effect size computation and power analysis are available.
Coordinated selection of procurement bids in finite capacity environments

Pressure to increase agility and reduce costs is pushing enterprises to dynamically select among offers from a broader range of suppliers. This process is facilitated by the adoption of web services standards. An important requirement in this context is the ability to move away from unidimensional price-based e-procurement models and develop richer solutions that are capable of capturing other important attributes in the selection of supplier bids. Research on the evaluation and selection of supplier bids (''winner determination'') has traditionally ignored the temporal and finite capacity constraints under which manufacturers and service providers often operate. We consider the problem faced by a firm that procures multiple key components or services from a number of possible suppliers. Bids submitted by suppliers include both a price and a delivery date. The firm has to select a combination of supplier bids that will maximize its overall profit. Profit is determined by the revenue generated by the products (or services) sold by the firm, the costs of the components (or services) it acquires as well as late delivery penalties it incurs if it fails to deliver its products/services in time to its own customers. We provide a formal model of this important class of problems, discuss its complexity and introduce rules that can be used to efficiently prune the resulting search space. We proceed to show that our model can be characterized as a pseudo-early/tardy scheduling problem and use this observation to build an efficient heuristic search procedure. Computational results show that our heuristic procedure typically yields solutions that are within a few percent from the optimum. They further indicate that taking into account the manufacturer/service provider's capacity can significantly improve its bottom line.
An intracellular adenine nucleotide binding site inhibits guanyly cyclase C by a guanine nucleotide-dependent mechanism

Guanylyl cyclase C (GCC), the receptor for the Escherichia coli heat-stable enterotoxin (ST), is inhibited by 2-substituted adenine nucleotides in an allosteric fashion. In confluent cultures of Caco-2 intestinal epithelial cells, extracellular 2-methylthioadenosine triphosphate (2MeSATP) had no effect on basal or ST-stimulated cyclic GMP (cGMP) accumulation. However, this nucleotide inhibited cGMP accumulation in digitonin-permeabilized Caco-2 human colon carcinoma cells, demonstrating that allosteric inhibition of GCC by adenine nucleotides is mediated by an intracellular adenine nucleotide binding site rather than purinergic receptors. The role of guanine nucleotides in the regulation of GCC by adenine nucleotides was examined. Increasing GTP concentrations from 5 to 100 microM increased the potency of 2MeSATP inhibition of GCC 20-fold, with a shift in the Ki from 447 to 22 microM, respectively. Also, the hydrolysis-resistant analogue, guanosine 5'-O-(3-thiotriphosphate) (GTPgammaS), supported 2MeSATP inhibition of GCC with a potency which was 10-fold greater than GTP. In addition, GTP alone, in the absence of adenine nucleotides and at concentrations greater than 1 mM, inhibited GCC through a mechanism convergent with 2MeSATP. Guanine nucleotides supported adenine nucleotide inhibition of GCC at low concentrations and directly inhibited this enzyme at high concentrations when these studies were conducted with receptors expressed in Caco-2 cells, native rat intestine, or cloned rat GCC heterologously expressed in 293 monkey kidney cells. These observations demonstrate that adenine nucleotide inhibition of GCC is mediated through an intracellular mechanism which is guanine nucleotide-dependent.
A model of mean zonal flows in the major planets

The linear theory of deep zonal flows developed by Busse (1976) for the origins of deep motions of the atmospheres of Jupiter and Saturn is extended into the nonlinear regime. Relationships for the relative magnitudes of convective heat and momentum transports are formulated. A perturbation approach is taken to the problem, with the amplitude of the convection serving as the small parameter, and the basic equations being expanded in terms of the Prandtl number. The Boussinesq approximation is employed, together with an assumption of a low Rossby number for the Jovian and Saturn atmospheres. Differences in the amplitude of the Jovian equatorial jet relative to that of Saturn are explored in terms of a low equatorial convective heat flux on Jupiter.
Memory effects in loudness scaling of traffic noise. How overall loudness of short-term and long-term sounds depends on memory.

The influence of cognitive factors such as attention, short-term, and long-term memory on overall loudness of non-steady state sound has not yet been systematically investigated.In this paper, preliminary experimental results are presented, showing how loudness scalings of non-steady state traffic noise depend on memory.
Signatures of quantum exciton transport in two-dimensional coherent optical signals of photosynthetic complexes

We present simulations of two dimensional spectra in the photosynthetic reaction center of photosystem II that clearly establish wavelike energy transport at room temperature. This transport mechanism survives decoherence due to the fluctuating protein environment.
When murder is not enough: Toward a new definition of community violence !

Homicide classification is classic criminological preoccupation, but criminology and criminal justice are only really ever concerned with the willful kind, which are murder and nonnegligent manslaughter. Other disciplines, such as epidemiology, do not operate such a differentiation and consider all homicides together, as one type of death, a violent one. This study adopts a broader, epidemiological approach to homicide, in order to understand classification effects at the death certification level. In order to achieve this goal, this article presents a procedural analysis of the classification of violent deaths based on systematic observations conducted in a medical examiner's office in an urban area. The ethnographic data show the many different procedural stages leading to death classification. They also uncover the complex web of informal rules, individual influences, institutional limitations, etc., making the classification system based more on "degrees of certainty" rather than a "true/false" statement.
Polymeric Adsorbent for Radium Removal from Groundwater

Radium removal from groundwater by adsorption on polymeric adsorbent represents the latest application of adsorption process in water treatment. A three-month pilot study was carried out in the customer site to collect process performance data on Dowex RSC (radium selective complexer) for a large scale plant design. It was observed from the pilot test that the RSC resin has exceptionally high adsorption capacity for radium, no radium breakthrough from 38″ RSC bed during the entire pilot test; however the adsorbent mass transfer zone extended with the progress of pilot test. The increasing mass transfer zone was probably caused by the changing adsorbent properties. This interesting phenomenon presents a very tough challenge to both adsorption process design and simulation. Another very unique aspect of this process is that the adsorbent with the exceptionally high adsorption capacity may not be suitable for this process due to radiation safety concern and waste disposal limit.
Effect of Dilute Polymer Additives on the Acoustic Cavitation Threshold of Water

Measurements are presented of the variation of the acoustic cavitation threshold of water with concentration of the polymer additives polyethylene oxide and guar gum. It was found that small amounts of these additives could significantly increase the cavitation threshold. A theoretical model, based upon nucleation of a gas bubble from a Harvey-type crevice in a mote or solid particle, is developed that gives good agreement with the measurements. The applicability of this approach to an explanation of cavitation index reduction in flow-generated or confined jet cavitation, when polymer additives are introduced, is discussed.
Improvement of cyclability of silicon-containing carbon nanofiber anodes for lithium-ion batteries by employing succinic anhydride as an electrolyte additive

Si/C composite nanofibers were prepared by electrospinning and carbonization using polyacrylonitrile as the spinning medium and carbon precursor. The effect of electrolyte additive succinic anhydride (SA) on the electrochemical performance of Si/C composite nanofiber anodes was investigated. Results show that after 50 cycles, the discharge capacity of Si/C composite nanofiber anode with the SA-added electrolyte is 34 % higher than that with additive-free electrolyte. At 150th cycle, the capacity retention of Si/C composite nanofiber anode with SA-added electrolyte is 82 % under 70 % state-of-charge. It is demonstrated that adding additive SA in the electrolyte is an effective and economic way to improve the cyclability of high-capacity Si/C composite nanofibers for next-generation high-energy lithium-ion batteries.
Congenital collision tumors, neonatal renal mesoblastic nephroma and pararenal paraganglioma

Congenital collision tumors, neonatal renal mesoblastic nephroma and pararenal paraganglioma
Incorporation of deoxythymidine triphosphate into DNA of fractions of mouse liver in vitro.

Abstract The heterochromatin fraction isolated from mouse liver nuclei incorporates more labeled dTTP into DNA than does the euchromatin fraction in an in vitro system for DNA synthesis. Saturation of these fractions with microbial DNA polymerase, as well as the use of isolated mouse satellite and main peak DNA, suggests that the heterochromatin DNA is not a better template than euchromatin DNA. The addition of exogenous DNA in the in vitro systems shows that heterochromatin has a higher level of dTTP incorporation than an equivalent amount of euchromatin DNA suggesting that a higher DNA polymerase activity is the primary cause of the higher level of incorporation of precursor into heterochromatin DNA in vitro.
Hydrodynamics of bioreactor systems for liquid-liquid contacting

Two liquid—liquid bioreactors, a stirred-tank and a novel electrostatic-dispersion system, are being used to investigate biodesulfurization of oil by sulfate-reducing bacteria (SRB). The hydrodynamic behavior of both bioreactors under various operating conditions is discussed in this article. The total liquid volume of the stirred-tank system is 1 L in a 1.5-L cylindrical tank equipped with two baffles and two Rushton-type six-blade impellers. The steady-state average drop size (d 32) was determined by a video technique, and correlated with operating conditions, physical properties, and system geometry. Although the stirred-tank geometry was not standard, the d 32correlation was found to be in good agreement with correlations reported in the literature. For the electrostatic dispersion system, a 0.25-L column was used with kerosene as the continuous phase and water containing SRB as the dispersed phase. Microdroplets were obtained by the break-up of the aqueous phase meniscus at the tip of a capillary tube using pulsed direct current (dc) electric fields. The size of the drops ejected from the capillary was measured as a function of the intensity of the applied voltage. Preliminary results showed no deleterious effect of electrospray dispersion on bacteria viability.
Impaired insulin secretion of aging: Role of renal failure and hyperparathyroidism

Impaired insulin secretion of aging: Role of renal failure and hyperparathyroidism. Available data indicate that insulin secretion is impaired with aging. Almost all the studies that examined insulin secretion by old animals did not take into consideration the state of renal function or the blood levels of parathyroid hormone (PTH). Old animals may have chronic renal failure (CRF) and secondary hyperparathyroidism, and both of these conditions impair insulin secretion. It is possible, therefore, that the impaired insulin secretion of aging is not due to old age per se , but rather to associated CRF and excess PTH. The present study examined this issue in adult (6 month old) and senescent rats (2 years old) with and without CRF and excess PTH. Senescent rats without CRF had normal renal function and normal blood levels of PTH, and the values were not different from those observed in adult rats. Creatinine clearance in senescent rats with CRF was significantly (P per se , but is due to the associated CRF and secondary hyperparathyroidism that develops in many, but not all old animals. Our results indicate that studies examining the effect of aging on body function should take into consideration the level of renal function and of the serum PTH, since both CRF and excess PTH adversely affect the functional integrity of many organs.
Global Sensitivity Analysis for Systems with Independent and/or Correlated Inputs

Abstract A new unified global sensitivity analysis framework is introduced for systems whose input probability distribution can be independent and/or correlated. For correlated inputs, three sensitivity indices are defined to fully describe the total, structural (reflecting the system structure) and correlative (reflecting the correlated input probability distribution) contributions for an input or a subset of inputs. The magnitudes of all three indices need to be considered in order to quantitatively determine the relative importance of the inputs. For independent inputs, these indices reduce to a single index consistent with previous variance-based methods. This analysis is especially useful for the treatment of laboratory and field data.
Lipid free radical generation and brain cell membrane alteration following nitric oxide synthase inhibition during cerebral hypoxia in the newborn piglet.

Abstract: Nitric oxide (NO) is reported to cause neuronal damage through various mechanisms. The present study tests the hypothesis that NO synthase inhibition by Nω-nitro-l-arginine (NNLA) will result in decreased oxygen-derived free radical production leading to the preservation of cell membrane structure and function during cerebral hypoxia. Ten newborn piglets were pretreated with NNLA (40 mg/kg); five were subjected to hypoxia, whereas the other five were maintained with normoxia. An additional 10 piglets without NNLA treatment underwent the same conditions. Hypoxia was induced with a lowered FiO2 and documented biochemically by decreased cerebral ATP and phosphocreatine levels. Free radicals were detected by using electron spin resonance spectroscopy with a spin trapping technique. Results demonstrated that free radicals, corresponding to alkoxyl radicals, were induced by hypoxia but were inhibited by pretreatment with NNLA before inducing hypoxia. NNLA also inhibited hypoxia-induced generation of conjugated dienes, products of lipid peroxidation. Na+,K+-ATPase activity, an index of cellular membrane function, decreased following hypoxia but was preserved by pretreatment with NNLA. These data demonstrate that during hypoxia NO generates free radicals via peroxynitrite production, presumably causing lipid peroxidation and membrane dysfunction. These results suggest that NO is a potentially limiting factor in the peroxynitrite-mediated lipid peroxidation resulting in membrane injury.
A Fuzzy Model of Glucose Regulation

We present a detailed glucose regulation model using fuzzy inference system (FIS) descriptions of hormonal control action and the familiar Michaelis---Menten (M---M) kinetic description for glucose transport. The fuzzy M---M model is compared and contrasted with a well-known comprehensive glucose model. The two models give similar results for glucose response, endogenous glucose production, and total uptake. The fuzzy M---M model features a renal subsystem that provides 25% of the endogenous glucose production. The work demonstrates the successful application of fuzzy logic and fuzzy inference to biological modelling. The flexibility of fuzzy inference, a linguistic description technique, permits conceptually simple statements about nonlinear processes.
Mating behaviour of Plodia interpunctella reared on juvenile hormone-treated diet

Abstract Treatment of larval Plodia interpunctella with sublethal doses of juvenile hormone repressed mating of the adults. This repression did not result from a reduced content of sex pheromone of females, but it may have been caused in part by reduced calling behaviour and abnormal antennae. An absence of juvenile hormone at the end of larval life is necessary for the development of normal reproductive behaviour of the adult.
A New Approach to Teaching Prehospital Trauma Care to Paramedic Students

Abstract Study objective: A modification of the standard Department of Transportation student paramedic curriculum encouraging individualized patient assessment decreases inappropriate on-scene procedures (OSPs) and scene time, measured on simulated patients. Methods: Scenario-based testing from 1991 through 1993 was videotaped for all students. A new trauma curriculum was introduced in 1992, individualizing patient assessment and prioritization of OSPs. Recorded OSPs included spinal immobilization, application of military antishock trousers, endotracheal intubation, cricothyrotomy, intravenous catheter insertion, and needle thoracostomy. Twenty videotaped random student performances of the 1991 class was compared with a similar sample of 20 from the 1993 class; scene times and the OSP numbers were measured. Two board-certified independent emergency physicians unfamiliar with the students or the new curriculum reviewed all 40 tests on a master videotape. Patient assessment appropriateness, scene time, OSPs, scenario difficulty, and number of inappropriate OSPs were evaluated using a linear analog scale. Data are presented as means with confidence intervals (CIs), analyzed by Student's t test and the Mann-Whitney 2-sample test. Results: Scene time from 1991 to 1993 decreased overall with a mean of 4.3 minutes (95% CI 2.8 to 5.8 minutes), as did the number of OSPs: 3.1 versus 1.7 (mean difference, 1.45 OSPs per scenario; 95% CI .91 to 1.99). Physician reviewers noted improvements in the appropriateness of patient assessment, scene time, and OSPs from 1991 to 1993. There was no significant difference in scenario difficulty for 1991 compared with 1993. Inappropriate OSPs done on scene declined. Physician 1 indicated a mean of inappropriate procedures of 1.6 in 1991 versus .5 in 1993. Physician 2 indicated a mean of 1.4 in 1991 versus .3 in 1993. Conclusion: This new paramedic curriculum decreased on-scene time and inappropriate use of procedures in stabilizing the condition of patients with simulated critical trauma. [Johnson DR, Macias D, Dunlap A, Hauswald M, Doezema D: A new approach to teaching prehospital trauma care to paramedic students. Ann Emerg Med January 1998;33:51-55.]
Influence of cryomilling on the microstructural features in HVOF-sprayed NiCrAlY bond coats for thermal barrier coatings: Creation of a homogeneous distribution of nanoscale dispersoids

Previous research has revealed that thermal barrier coatings with cryomilled bond coats exhibit improved thermal cycling lifetime by growing a continuous and uniform oxide layer at a slower rate; yet the mechanism controlling the ultimate failure remains unclear. In an effort to provide a foundation for understanding the improved behavior, the influence of cryomilling on the microstructure of the NiCrAlY bond coat material is investigated in this article. Rather than focusing on the alumina scale formation, the microstructural features and their evolution within the high-velocity oxy-fuel (HVOF)-sprayed NiCrAlY bond coats themselves, prepared from conventional powder and cryomilled powder, were carefully compared through extensive scanning electron microscope/energy-dispersive X-ray spectroscopy characterization. In addition, the as-cryomilled NiCrAlY powder is characterized to provide evidence of the direct influence of cryomilling and to exclude the impact from the HVOF spraying. It is found that the es...
Incorporation of Plant Residues into Soil Organic Matter Fractions With Grassland Management Practices in the North American Midwest

Disturbed grassland soils are often cited as having the potential to store large amounts of carbon (C). Fertilization of grasslands can promote soil C storage, but little is known about the generation of recalcitrant pools of soil organic matter (SOM) with management treatments, which is critical for long-term soil C storage. We used a combination of soil incubations, size fractionation and acid hydrolysis of SOM, [C], [N], and stable isotopic analyses, and biomass quality indices to examine how fertilization and haying can impact SOM dynamics in Kansan grassland soils. Fertilized soils possessed 113% of the C possessed by soils subjected to other treatments, an increase predominantly harbored in the largest size fraction (212–2,000 μm). This fraction is frequently associated with more labile material. Haying and fertilization/haying, treatments that more accurately mimic true management techniques, did not induce any increase in soil C. The difference in 15N-enrichment between size fractions was consistent with a decoupling of SOM processing between pools with fertilization, congruent with gains of SOM in the largest size fraction promoted by fertilization not moving readily into smaller fractions that frequently harbor more recalcitrant material. Litterfall and root biomass C inputs increased 104% with fertilization over control plots, and this material possessed lower C:N ratios. Models of incubation mineralization kinetics indicate that fertilized soils have larger pools of labile organic C. Model estimates of turnover rates of the labile and recalcitrant C pools did not differ between treatments (65.5 ± 7.2 and 2.9 ± 0.3 μg C d−1, respectively). Although fertilization may promote greater organic inputs into these soils, much of that material is transformed into relatively labile forms of soil C; these data highlight the challenges of managing grasslands for long-term soil C sequestration.
Osmotic adjustment and growth responses of three Chrysanthemum morifolium Ramat. cultivars to osmotic stress induced in vitro

Abstract In vitro‐grown Chrysanthemum morifolium Ramat. cultivars Bright Golden Anne, Deep Luv, and Lucido were exposed to elevated mannitol, sucrose, or sorbitol concentrations to see if their response to this osmotic stress mimics that of in vivo plants enduring water deficit. The relative efficacy of the three osmotic agents at manifesting a response was also evaluated. Tissue osmolarity paralleled media mannitol and sorbitol concentration for all three cultivars. Shoot growth correspondingly decreased with increased osmolarity applied during the rooting phase. These responses generally resembled those of water‐stressed greenhouse plants. The degree of response varied with cultivar; ‘Lucido’ was the most sensitive and ‘Bright Golden Anne’ the least. Sucrose (metabolized by the plants) failed to elicit consistent osmotic stress symptoms; instead it enhanced both shoot and root growth. In vitro stress‐induced symptoms were produced in both proliferation and rooting stages, but consistent shoot growth red...
Simulation in manufacturing: A regression metamodel approach

Abstract The application of regression metamodels to simulation outputs is illustrated in this paper. With increasing interests in applying simulation to complex manufacturing problems, regression metamodels can greatly reduce the cost, time, and the amount of effort spent in conducting simulation. These models can also be generalized within the bounds defined for the problem's parameters. The use of a regression metamodel to conduct sensitivity analysis, application in “optimizing” manufacturing systems, and the validity of the model are illustrated. An example is given with a maintenance float problem.
The improper use of fossil nomenclature

Retention of obsolete genera and species, and premature acceptance of provisional genera and species unnecessarily inhibit meaningful communication between students of fossil man.
Sensitivities by the state variable approach: Research sponsored by the U. S. Atomic Energy Commission under contract with the Union Carbide Corporation

The well-known procedures for calculating transient-re sponse sensitivities, frequency-response sensitivities, and pole sensitivities have been successfully and profitably applied for several years. However, the usual formulations are not well suited for analysis of large systems on modern analog or digital computers. Expressions for these sensitivi ties are developed in this paper using simple matrix ma nipulations (usually referred to as the state variable ap proach). The state variable formulation illustrates clearly the structure of the sensitivity equations and provides an efficient procedure for computer calculations.
Injection of WGA-Alexa 488 into the ipsilateral hemidiaphragm of acutely and chronically C2 hemisected rats reveals activity-dependent synaptic plasticity in the respiratory motor pathways

WGA-Alexa 488 is a fluorescent neuronal tracer that demonstrates transsynaptic transport in the central nervous system. The transsynaptic transport occurs over physiologically active synaptic connections rather than less active or silent connections. Immediately following C2 spinal cord hemisection (C2Hx), when WGA-Alexa 488 is injected into the ipsilateral hemidiaphragm, the tracer diffuses across the midline of the diaphragm and retrogradely labels the phrenic nuclei (PN) bilaterally in the spinal cord. Subsequently, the tracer is transsynaptically transported bilaterally to the rostral Ventral Respiratory Groups (rVRGs) in the medulla over physiologically active connections. No other neurons are labeled in the acute C2Hx model at the level of the phrenic nuclei or in the medulla. However, with a recovery period of at least 7weeks (chronic C2Hx), the pattern of WGA-Alexa 488 labeling is notably changed. In addition to the bilateral PN and rVRG labeling, the chronic C2Hx model reveals fluorescence in the ipsilateral ventral and dorsal spinocerebellar tracts, and the ipsilateral reticulospinal tract. Furthermore, interneurons are labeled bilaterally in laminae VII and VIII of the spinal cord as well as neurons in the motor nuclei bilaterally of the intercostal and forelimb muscles. Moreover, in the chronic C2Hx model, there is bilateral labeling of additional medullary centers including raphe, hypoglossal, spinal trigeminal, parvicellular reticular, gigantocellular reticular, and intermediate reticular nuclei. The selective WGA-Alexa 488 labeling of additional locations in the chronic C2Hx model is presumably due to a hyperactive state of the synaptic pathways and nuclei previously shown to connect with the respiratory centers in a non-injured model. The present study suggests that hyperactivity not only occurs in neuronal centers and pathways caudal to spinal cord injury, but in supraspinal centers as well. The significance of such injury-induced plasticity is that hyperactivity may be a mechanism to re-establish lost function by compensatory routes which were initially physiologically inactive.
Polarized absorption spectroscopy as a tool in studying guest-host interactions in a nematic lyotropic liquid crystal

Abstract Magnetically aligned samples of the nematic lyotropic liquid crystal prepared by dissolving disodium cromoglycate in water were studied via polarized absorption spectroscopy. The order parameters of the host as well as those of a wide variety of guest dye molecules were determined and correlated with structure of dye, ionic strength of medium, and temperature effects. In general, order parameter of guests increases with ionic strength, and decreases with increasing temperature. Very large molecules tend to orient parallel to the axis of the nematic cylinder, whereas small molecules lie perpendicular to this axis. The order parameter of the host is S = -0.20, consistent with values obtained by other methodologies.
Correlation between structure and glycogen content of livers from rats on a controlled feeding schedule

Male rats were maintained on a controlled feeding schedule and groups of animals sacrificed at 2, 15, 21, 36, 48 and 72 hours of fasting. Chemical determinations of glycogen showed that livers of rats fasted two hours contained 8.7% glycogen; 15 hours, 6.2%; 21 hours, 0.7%; 36 hours, 0.7%; 48 hours, 0.8%; and 72 hours, 0.4%. After PA/S procedures, glycogen appeared in hepatocytes of rats fasted 2 and 15 hours as large masses intensely stained. At these time-periods, almost all cells contained significant quantities of glycogen but hepatocytes located toward portal tracts showed larger and more intensely stained masses of glycogen than found in cells near central veins. After longer periods of fasting, glycogen masses decreased in size, number, and staining intensity. The fine structure of hepatocytes from rats fasted 2 or 15 hours showed abundant α and β particles of glycogen in the form of large masses throughout the cytosome. These correlated in position and shape to the masses of glycogen seen in the light microscope. As glycogen depletion occurred (fasted 21 hours and longer) the number of glycogen particles decreased in hepatocytes. It is concluded from this study that a good correlation exists between chemical determinations of hepatic glycogen, cytochemistry of glycogen in hepatocytes, fine structure of liver cells, and the fasting state of the animal.
Social justice as a Holy Grail: The endless quest

This paper gives the author's impressions on the following aspects of justice: desert, equity, equality, need, and intergenerational equity. The author concludes that these different aspects cannot be reconciled but instead must be compromised. An example of such a compromise is provided by a discussion of welfare reform. The author claims that rights are correlative with duties, and that asserting the former has little meaning without specifying the latter. He then discusses justice toward groups rather than individuals. He proposes that maintaining cultural variety in the presence of a homogeneous “superculture” is a major problem of the contemporary world. The paper concludes with a discussion of various forms of power, particularly the “integrative power” that people acquire over each other by virtue of ties of loyalty and identity.
Mahadevi Varma and the Chhayavad Age of Modern Hindi Poetry

Mahadevi Varma was one of the leading poets of the romantic movement in Hindi poetry during the 1920s and 1930s, known as the Chhayavad phase. Besides being a poet, she was a writer of prose sketches, a translator of Sanskrit, and a literary theorist. This study combines intellectual history, biography and literary criticism, presenting the poet objectively within her concrete social and intellectual environment. This book is intended for general readers, scholars and researchers in Hindi.
8Gb/s capacitive low power and high speed 4-PWAM transceiver design

In this paper, capacitive 4-PWAM transmitter architectures and circuits are proposed and its performances are analyzed with random jitter and PVT variation comparing with other works. A novel technique is proposed to reduce power and to increase speed by using capacitive driven low swing transceiver. The proposed design saves 1.74~2.4x power and 4x higher data rate than conventional designs. To implement 4-PWAM transmitter new phase controller and adaptive capacitance network are designed. At receiver side, new architectures for PWM and PAM demodulation are proposed.
Age-related changes of cell death pathways in rat extraocular muscle

Changes in the structure and function of aging non-locomotor muscles remains understudied, despite their importance for daily living. Extraocular muscles (EOMs) have a high incidence of age-related mitochondrial defects possibly because of the metabolic stress resulting from their fast and constant activity. Apoptosis and autophagy (type I and II cell death, respectively) are linked to defects in mitochondrial function and contribute to sarcopenia in hind limb muscles. Therefore, we hypothesized that apoptosis and autophagy are altered with age in the EOMs. Muscles from 6-, 18-, and 30-month-old male Fisher 344-Brown Norway rats were used to investigate type I cell death, caspase-3, -8, -9, and -12 activity, and type II cell death. Apoptosis, as measured by TUNEL positive nuclei, and mono- and oligo-nucleosomal content, did not change with age. Similarly, caspase-3, -8, -9, and -12 activity was not affected by aging. By contrast, autophagy, as estimated by gene expression of Atg5 and Atg7, and protein abundance of LC3 was lower in EOMs of aged rats. Based on these data, we suggest that the decrease in autophagy with age leads to the accumulation of damaged organelles, particularly mitochondria, which results in the decrease in function observed in EOM with age.
Dynamic aperture optical arrays based on polymeric MEMS actuators for large scale coding elements with application in visible to MWIR

Extension of coded apertures to the MWIR introduces the effects of diffraction and other distortions not observed in shorter wavelength systems. A new approach is being developed under the DARPA/SPO funded LACOSTE (Large Area Coverage Optical search-while Track and Engage) program, that addresses the effects of diffraction while gaining the benefits of coded apertures, thus providing flexibility to vary resolution, possess sufficient light gathering power, and achieve a wide field of view (WFOV). The photonic MEMS "eyelid" array technology is currently being instantiated in this DARPA Surveillance program study as the "heart", mediating the flow of the incoming signal. However, speed, lifetime, packaging and scalability are critical factors for the MEMS "eyelid" technology which will determine system efficacy as well as military and commercial usefulness. The electronic eyelid array is the fundamental addressable unit for adaptive code generation and will allow the system to multiplex in time for increased resolution. The binary code which determines whether a 500μm eyelid is open or closed is referred to as the "eyelid code." Groups of eyelids can work together as a "super aperture" by virtue of a "macro-code." A macro code becomes relevant to describe how dispersed eyelids across the 0.19m x 0.19m aperture will function together. Dynamic aperture arrays were fabricated on both quartz and sapphire substrates for operation in the visible to MWIR. Both 8x8 and 40x40 element arrays were designed, fabricated, and tested with macro-codes consisting of 4, 8, and 16 unique combinations. The die were packaged and tested in ambient for robust eyelid operations. The point spread function was also measured in an optical setup with the eyelid arrays located in the aperture plane.
Local effects of impactors on concrete structures

Abstract Available formulae for predicting the penetration depth, scabbing thickness, and perforation thickness of concrete structures impacted by solid missiles are summarized, reviewed, and compared. Based on quadratic and cubic regression analysis of existing data, two new formulae have been proposed for predicting the penetration depth of concrete due to the impact by solid missiles. The new penetration equations are compared statistically with NDRC penetration formula and two other recent penetration formulae. Also, new simple formulae have been proposed for predicting the scabbing thickness and perforation thickness of concrete walls.
Economics and ethics

Business theory and management practices are outgrowths of basic economic principles. To evaluate the proper place of ethics in business, the meaning of ethics as defined by economic theory must be assessed. This paper contends that classical economic thought advocates a nonethical decision-making context and is not functional for a modern complex, interdependent environment.
Thermoelectric Module-Variable Conductance Heat Pipe Assemblies for Reduced Power Temperature Control

Thermoelectric modules (TEMs) are used to precisely maintain the setpoint temperature of photonic components generating variable heat loads under varying ambient conditions. The non-component side of TEMs is mounted onto conventional heat sinks (CHSs). At any combination of setpoint temperature, heat load and ambient temperature, there is a unique thermal resistance between the non-component side of a TEM and the ambient corresponding to minimal TEM power consumption. Indeed, a zero thermal resistance heat sink minimizes power consumption when a TEM operates in refrigeration mode, but when it operates in heating mode a relatively high thermal resistance one is optimal. This paper considers replacing a CHS with a variable thermal resistance heat sink in the form of a finned variable conductance heat pipe (FVCHP). An FVCHP passively and (generally) favorably alters its thermal resistance in response to changes in operating conditions, thereby reducing TEM power consumption. An analytical model of a TEM-FVCHP assembly is developed in order to quantitatively estimate achievable energy savings. The model assumes that there is 1-D flow of heat and charge through a TEM and that a “flat front” divides the condenser section of an FVCHP into thermally active and inactive regions. Calculations are performed for representative TEM-FVCHP assemblies that maintain the setpoint temperature of a photonics component over prescribed ranges of heat loads and ambient temperatures. Average TEM power consumption is reduced by up to 55% compared to a comparable TEM-CHS assembly. Finally, further optimization of the TEM and FVCHP design parameters is considered.
"Drinking is fun" and "There's nothing you can do about it": the problem with the 21-year-old minimum drinking age.

(2007). 'Drinking is Fun' and 'There's Nothing You Can Do About It': The Problem With the 21-Year-Old Minimum Drinking Age. Journal of American College Health: Vol. 56, No. 3, pp. 213-216.
Purification and properties of pig heart pyruvate kinase.

Using essentially a two-step procedure involving phosphocellulose column chromatography followed by gel filtration on Sephadex G200, pig heart pyruvate kinase (PH PyK) was purified 267-fold to at least 97% purity. PH PyK co-sedimented with rabbit muscle PyK during sucrose density ultracentrifugation yielding an S20,w of 10 and a corresponding molecular weight of about 237,000. Sodium docedyl sulfate polyacrylamide gel electrophoresis yielded a subunit molecular weight of approximately 59,000, suggesting that native PH PyK exists as a tetramer. The isoelectric point (pI) was determined to be 8.2, and thepH optimum (pHo) for the forward reaction is 7.2. Steady-state kinetics with phospho(enol)pyruvate (PEP) as the variable substrate show that there is a threefold decrease in the Km for PEP in the presence of 1.0 mM fructose-1,6-diphosphate (FDP), and that the activity of PH PyK is increased over fourfold by FDP at low (0.1 mM) PEP concentrations. Lineweaver-Burk plots are linear in the presence and absence of FDP, indicating that the Michaelis-Menten curves are hyperbolic. The amino acid composition for pig heart PyK shows close similarities between pig muscle and kidney PyKs, but not liver PyK. Among the data on pI,pHo, and FDP activation, only the activation by FDP is useful in tentatively designating pig heart PyK as an M2 isozyme.
Three-dimensional massive gauge theories

Three-dimensional Yang-Mills and gravity theories augmented by gauge-invariant mass terms are analyzed. These topologically nontrivial additions profoundly alter the particle content of the models and lead to quantization of a dimensionless mass-coupling-constant ratio. The vector field excitations become massive, with spin 1 (rather than massless with spin 0), and the mass provides an infrared cutoff. The gravitation acquires mass, mediates finite-range interactions, and has spin 2 (rather than being absent altogether); although its mass term is of third derivative order, there are no ghosts or acausalities.
Magnetic servo levitation by sliding-mode control of nonaffine systems with algebraic input invertibility

Magnetic Servo Levitation (MSL) is an important actuation principle with potential applications ranging from ultrahigh-precision positioning to high-speed rail systems. This paper describes a nonlinear controller design technique for MSL that has inherent robustness to both parametric uncertainties and unmodeled dynamics. Most of the currently available literature on sliding mode considers nonlinear systems that are linear (affine) in the input action. The proposed technique allows designing sliding-mode controllers for the family of nonaffine problems that have an input nonlinearity algebraically invertible with respect to the available control action. This differs from the standard approach of input feedback linearization, and is based on a modified sliding condition that can be used to synthesize a switching control law. An equivalent control term can also be included, substantially enhancing the performance of the controller. Experimental results show that the proposed technique can achieve excellent tracking at high speeds in a fast-tool servo system actuated by MSL.
Accommodating bursts in distributed stream processing systems

Stream processing systems have become important, as applications like media broadcasting, sensor network monitoring and on-line data analysis increasingly rely on real-time stream processing. Such systems are often challenged by the bursty nature of the applications. In this paper, we present BARRE (Burst Accommodation through Rate REconfiguration), a system to address the problem of bursty data streams in distributed stream processing systems. Upon the emergence of a burst, BARRE dynamically reserves resources dispersed across the nodes of a distributed stream processing system, based on the requirements of each application as well as the resources available on the nodes. Our experimental results over our Synergy distributed stream processing system demonstrate the efficiency of our approach.
Distributions Possessing a Monotone Likelihood Ratio

Abstract A sufficient condition for the validity of the commonly used one-sided tests is that the underlying density p(x, ω), where x is the observed variable and ω the unknown parameter, possess a “monotone likelihood ratio.” In estimation, only monotone functions of the observed variable x should be used as possible estimating functions of ω.
Strength of Stiffened Flanges in Horizontally Curved Box Girders

Longitudinal stiffeners are often attached to increase the buckling strength of thin-walled box girder flanges. The minimum required rigidity for longitudinal stiffeners for curved box girder flanges is given by the AASHTO "Guide specifications for horizontally curved steel girder highway bridges." However, this requirement is simply adopted from the current AASHTO specifications for straight stiffened flanges. The validity of this requirement has been questioned in a series of recent studies. The effect of important design parameters on the minimum required stiffener rigidity is investigated numerically in this study by examining the prebuckling stress distribution and elastic and inelastic buckling stresses of horizontally curved stiffened flanges. In order to characterize and quantify the analytically collected data, a series of parametric studies were performed. A new equation for the minimum required rigidity for the longitudinal stiffeners is derived from regression analyses. Through the evaluation of a few selected case studies and a design example, the validity and reliability of the proposed new equation is demonstrated.
Modulation transfer function measurements of microjetted microlenses

We measured the modulation transfer function for microjetted microlenses with diameters ranging between 109 and 400 microm and with focal lengths ranging between 135 and 540 microm. We found that single-drop 109-microm-diameter microlenses perform close to their theoretical cutoff frequency. However, the larger lenses made with multiple droplets have a cutoff frequency that is 35% of the theoretical value. We interpret this as an illustration of the rapid increase in spherical aberration as the diameter of a lens increases.