cssi/SciSciGPT-SciSciNet huggingface dataset:
Quadratic variance models for adaptively preprocessing SELDI-TOF mass spectrometry data

Surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI) is a proteomics tool for biomarker discovery and other high throughput applications. Previous studies have identified various areas for improvement in preprocessing algorithms used for protein peak detection. Bottom-up approaches to preprocessing that emphasize modeling SELDI data acquisition are promising avenues of research to find the needed improvements in reproducibility. We studied the properties of the SELDI detector intensity response to matrix only runs. The intensity fluctuations and noise observed can be characterized by a natural exponential family with quadratic variance function (NEF-QVF) class of distributions. These include as special cases many common distributions arising in practice (e.g.- normal, Poisson). Taking this model into account, we present a modified Antoniadis-Sapatinas wavelet denoising algorithm as the core of our preprocessing program, implemented in MATLAB. The proposed preprocessing approach shows superior peak detection sensitivity compared to MassSpecWavelet for false discovery rate (FDR) values less than 25%. The NEF-QVF detector model requires that certain parameters be measured from matrix only spectra, leaving implications for new experiment design at the trade-off of slightly increased cost. These additional measurements allow our preprocessing program to adapt to changing noise characteristics arising from intralaboratory and across-laboratory factors. With further development, this approach may lead to improved peak prediction reproducibility and nearly automated, high throughput preprocessing of SELDI data.
The Mormons versus the ‘Armies of Satan’: CompetingFrames of Morality in the Brokeback Mountain Controversy in Utah Newspapers

Analyzing Utah op-ed columns and letters to the editor, this essay considers the news media's role in framing public debate regarding the 2006 cancellation of the film Brokeback Mountain because of its themes of gay love and homophobia. Our study interrogates journalists' and citizen letter-writers' discourse on either side of the issue as it played out in the press. The discourse breaks down into two diametrically opposed frames—Defending Zion versus Disrupting Zion—but each argues for the same thing: to protect different perspectives of morality. The values underlying each framing strategy reveal tensions in an LDS Church-dominated culture with a growing “Gentile” population.
FACTORS WHICH INFLUENCE DELAYED OR MISSED NEWBORN SCREENING IN CRITICALLY ILL INFANTS 621

Newborn screening guidelines in North Carolina recommend that the newborn screening test be obtained by filter paper sample prior to discharge(including hospital transfers) regardless of age or within the first 72 hours. Current policy recommends rescreening by 7 days of age if the sample was collected at 80% tested). Delayed or missed screening most often occurred when an infant was transferred multiple times or admitted to other pediatric services. Some factors that contributed to missed screens included early infant death and severe congenital heart disease with some requiring early surgery. Verification of medical record newborn screening data by comparison with state laboratory data is now in progress.
Infant-mother attachment: Relationships to maternal responsiveness and infant temperament*

The purpose of this study was to explore the relationships between maternal responsiveness, infant temperament, and infant-mother attachment as measured in Ainsworth's Strange Situation. Discriminant analysis revealed that infant temperament was more strongly related to attachment than maternal responsiveness. Infants rated as Anxious-Avoidant in attachment were perceived by their mothers as significantly easier in temperament. Possible explanations for findings and implications for nurses working with infants and parents are discussed.
Impacts of operating conditions and solution chemistry on osmotic membrane structure and performance

Abstract Herein, we report on changes in the performance of a commercial cellulose triacetate (CTA) membrane, imparted by varied operating conditions and solution chemistries. Changes to feed and draw solution flow rate did not significantly alter the CTA membrane's water permeability, salt permeability, or membrane structural parameter when operated with the membrane skin layer facing the draw solution (PRO-mode). However, water and salt permeability increased with increasing feed or draw solution temperature, while the membrane structural parameter decreased with increasing draw solution, possibly due to changes in polymer intermolecular interactions. High ionic strength draw solutions may de-swell the CTA membrane via charge neutralization, which resulted in lower water permeability, higher salt permeability, and lower structural parameter. This observed trend was further exacerbated by the presence of divalent cations which tends to swell the polymer to a greater extent. Finally, the calculated CTA membrane's structural parameter was lower and less sensitive to external factors when operated in PRO-mode, but highly sensitive to the same factors when the skin layer faced the feed solution (FO-mode), presumably due to swelling/de-swelling of the saturated porous substructure by the draw solution. This is a first attempt aimed at systematically evaluating the changes in performance of the CTA membrane due to operating conditions and solution chemistry, shedding new insight into the possible advantages and disadvantages of this material in certain applications.
Computing Smooth Time Trajectories for Camera and Deformable Shape in Structure from Motion with Occlusion

We address the classical computer vision problems of rigid and nonrigid structure from motion (SFM) with occlusion. We assume that the columns of the input observation matrix W describe smooth 2D point trajectories over time. We then derive a family of efficient methods that estimate the column space of W using compact parameterizations in the Discrete Cosine Transform (DCT) domain. Our methods tolerate high percentages of missing data and incorporate new models for the smooth time trajectories of 2D-points, affine and weak-perspective cameras, and 3D deformable shape. We solve a rigid SFM problem by estimating the smooth time trajectory of a single camera moving around the structure of interest. By considering a weak-perspective camera model from the outset, we directly compute euclidean 3D shape reconstructions without requiring postprocessing steps such as euclidean upgrade and bundle adjustment. Our results on real SFM data sets with high percentages of missing data compared positively to those in the literature. In nonrigid SFM, we propose a novel 3D shape trajectory approach that solves for the deformable structure as the smooth time trajectory of a single point in a linear shape space. A key result shows that, compared to state-of-the-art algorithms, our nonrigid SFM method can better model complex articulated deformation with higher frequency DCT components while still maintaining the low-rank factorization constraint. Finally, we also offer an approach for nonrigid SFM when W is presented with missing data.
Independent component analysis for GPR-based handheld mine detection

Unlike Vehicle-mounted ground penetrating radar (GPR), the hand-held GPR data is highly variable. In this paper we propose an independent component analysis (ICA) based approach for processing hand held stepped frequency GPR data for mine detection. ICA is a linear transformation, which seeks prominent features in high-dimensional data. Compared to principal component analysis (PCA), which searches for basis vectors in the direction of maximum variance, ICA finds more interesting features in the direction of maximum non-gaussianity. In our current implementation, ICA is used to find a set of basis vectors corresponding to the background clutter. Residual error for this GPR with respect to ICA clutter basis shows the presence or absence of landmine. The performance of the ICA based detection is compared with the correlation detector for GPR only data for hand held mine detection. Comparative receiver operating characteristics (ROC) curves representing probability of detection verses false alarm rate are shown for both scan and investigative mode for ICA based detection and correlation detection.
Encoding the unexpected.

One of the few truly general ideas that we have in neurophysiology is that organisms try to reduce deviations from their normal states. This idea, which has a long and interesting history, is now widely known as the ‘cybernetic principle’, or, more descriptively perhaps, the ‘negative feedback principle'. It holds that an adaptive system can maintain a stable state in a fluctuating environment if it can sense deviations from that state and initiate actions to reduce them. Probably the most familiar physiological examples are the homeostatic mechanisms that maintain the constancy of the internal environment, and the system of postural reflexes that tend to restore an animal’s original position with respect to gravity whenever it has changed. Although the cybernetic principle applies more directly to neurophysiological systems, it has also been adopted gratefully by many psychologists. What appears at a physiological level as an effort to maintain homeostatic equilibrium emerges at a behavioural level as a system of drives that motivate vital behaviour. And what appears at a physiological level as feedback of information about deviations from an expected result emerges at a psychological level as a complex perceptual system for the guidance of coordinated action. Thus, psychological theories of both motivation and perception have been strongly affected by this negative feedback principle borrowed from electrical engineering.
Yes, We're Fishing-In Rough Waters for Hard-to-Find Fish

In their focal article, Ruggs et al. (2013) outline the missed opportunities for researchers within industrial–organizational (I–O) psychology in examining marginalized employees. The authors identify seven groups as having been overlooked by I–O psychologists and thus deserving greater attention in the future. They conclude their focal article by noting that, “Instead of being on the front line serving as scientists and allies for those who are marginalized and treated poorly, we have let these individuals take a backseat while we have gone fishing.” We disagree with this assertion. It is not that we have gone fishing and ignored marginalized employees. Rather, we have gone fishing, in rough waters, to locate hard-to-find fish. We are not purposefully ignoring marginalized employees. On the contrary, we are conducting research while battling numerical representation issues and ethical and administration issues. The focus of our commentary is to highlight these challenges and offer suggestions for addressing them in an effort to assist researchers in actually doing what the authors of the focal article are calling for them to do—to successfully engage in more focused research on these under-represented members of the workforce.
Automatic classification of node types in switch-level descriptions

In switch-level simulation, nodes carry a charge on their parasitic capacitance from one evaluation to the next, which gives them a memory quality. A node is classified as temporary if its memory aspect is lost and cannot affect the circuit operation, whereas a node is classified as a memory node if the memory of the node is maintained and can affect the circuit operation. Accurate classification of nodes into temporary and memory nodes increases the performance of compiled simulators and high-level model generators. An approach for reliable automatic classification of nodes in a switch-level description is introduced. Both an exhaustive, exponential-time algorithm and a polynomial-time heuristic are presented. The heuristic was implemented and tested for several large circuits, including a commercial microprocessor. For this processor, the proposed heuristics identified an average of 92% of all nodes as temporary nodes. The heuristic was applied in a high-level model generator and significantly increased its performance. >
The Political Economy of Early Southern Unionism: Race, Politics, and Labor in the South, 1880–1953

Southern unions were the weak link in the American labor movement, organizing a smaller share of the labor force than did unions in the northern states or in Europe. Structural conditions, including a racially divided rural population, obstructed southern unionization. The South's distinctive political system also blocked unionization. A strict racial code compelling whites to support the Democratic Party and the disfranchisement of southern blacks and many working-class whites combined to create a one-party political system that allowed southern politicians to ignore labor's demands. Unconstrained by working-class voters, southern politicians facilitated strikebreaking and favored employers against unions.
Postmalaria Neurological Syndrome after Treatment of Plasmodium falciparum Malaria in the United States

The neuropsychiatric manifestations of postmalaria neurological syndrome (PMNS) that have been described are highly variable and include an acute confusional state or acute psychosis with >or=1 of the following symptoms: clouding of consciousness, inappropriate speech or behavior, visual hallucination, catatonia with waxy flexibility, generalized convulsion, fine postural tremor, and decreased muscle tone. This postinfectious syndrome occurs after the clearance of parasitemia and is not a manifestation of cerebral malaria. We present the first identified case of and magnetic resonance imaging findings for a patient with PMNS in the United States.
Analytical Force Calculations and Scaling Effects for Cylindrical and Cuboidal Micro-Magnets

An analytical method is used to derive explicit solutions for the forces between two well-defined magnetic fields. The method is applied to predict the forces between cylindrical and cuboidal magnets. These results are used to explore scaling laws and geometrical considerations for microscale magnets which can be used to optimize the magnetic forces for various magnetic sensors and actuators.
Associations of educational attainment, occupation and community poverty with knee osteoarthritis in the Johnston County (North Carolina) osteoarthritis project

Introduction The purpose of this study was to examine data from the Johnston County Osteoarthritis (OA) Project for independent associations of educational attainment, occupation and community poverty with tibiofemoral knee OA.
Electrophilic (Li^+) acceleration of C-H reductive elimination and oxidative addition reactions of Os(II)/Os(0) nitrosyl complexes

The reductive elimination of methane from cis,trans-Os(H)2(CH3)(NO)L2 (L = PiPr3) in benzene is accelerated by added LiN(SiMe3)2, with 1H NMR and IR evidence for binding of the lithium electrophile to NO oxygen. Oxidative addition of benzene to the transient OsH(NO)L2, to give cis,trans-Os(H)2(C6H5)(NO)L2, is also accelerated by LiN(SiMe3)2. DFT calculations of the reaction path with and without LiNMe2 show the rate acceleration is due to preferential stabilization of the oxidative addition/reductive elimination transition state, due to the greater back donation to NO in the TS. This is traced, in turn, to the relief of the filled–filled repulsion between the occupied Os d and C–H σ-orbitals by the Li electrophile on NO oxygen.
Sexual and Aggressive Conflicts in an Adolescent Girl: Discussion of Dr. Alvarez's Case Presentation

From the perspective of modern conflict theory, greater emphasis might have been placed on a variety of sexual and aggressive conflicts whose presence were suggested in the material presented by Dr. Alvarez. Included among these possibilities are: conflicts about menarche, guilt-inspired fears of punishment associated with sexual maturation and participation, and with competitive wishes in respect to other women, as well as concerns about genital anatomy and damage. A technical question is also raised about the way the analyst's clinical intuition is employed in response to dreams and symptoms. Finally, it is suggested that analytic attention to somatic symptoms ought to be deployed more cautiously than in the fashion described in this presentation.
Neuroticism and affective instability: the same or different?

Objective: The purpose of this study was to examine the correlates and consequences of two constructs related to affective experience: neuroticism and affective instability. Method: One hundred thirty-two patients were assessed at intake for axis I and II symptoms, general personality traits, and specific impairments, including impairments in interpersonal functioning. The data included responses to structured and semistructured interviews, selfreports of interpersonal problems, and reports of interpersonal problems from significant others. Clinical ratings of axis I and II symptoms and of impairment were made by using the LEAD (i.e., longitudinal, expert, all data) consensus approach. Ninety-one of the 132 patients were reassessed at 12-month follow-up. Results: Neuroticism and affective instability manifested varied concurrent relations, with neuroticism being strongly related to an anxious, avoidant style and affective instability related to more externalizing personality styles. Prospectively, neuroticism predicted later symptoms, occupational impairment, and global dysfunction, whereas affective instability predicted romantic impairment. Conclusions: The findings suggest that neuroticism and affective instability— which are considered core aspects of personality pathology—are related but distinct constructs with unique correlates and different predictive abilities.
Stacked multiband fractal patch antennas

In this work, the Sierpinski carpet microstrip patch is modified by stacking iterations to achieve multiband frequency operation and miniaturization.
Investigation of oxidation profile in PMR-15 polyimide using atomic force microscope (AFM)

Nanoindentation measurements are made on thermosetting materials using cantiever deflection vs. piezoelectric scanner position behavior determined by AFM. The spring model is used to determine mechanical properties of materials. The generalized Sneddon's equation is utilized to calculate Young's moduli for thermosetting materials at ambient conditions. Our investigations show that the force-penetration depth curves during unloading in these materials can be described accurately by a power law relationship. The results show that the accuracy of the measurements can be controlled within 7%. The above method is used to study oxidation profiles in Pl\1R-15 polyimide. The thermo-mechanical profiles ofPNIR-15 indicate that the elastic modulus at the surface portion of the specimen is different from that at the interior of the material. It is also shown that there are two zones within the oxidized portion of the samples. Results confirm that the surface layer and the core material have substantially different properties.
Contextion: A Framework for Developing Context-aware Mobile Applications

Context-aware mobile interfaces that are dynamic and adapt to each user pose a challenge to developers because the interface must continually adapt to accommodate changes in the user's activity and environment. Current methods of development do not allow for efficient creation of contextual applications. In addition, although data from sensors on a mobile device provides a rough estimation of a user's environment, the data needs to be combined in an intelligent way in order to determine a user's intention. In this paper we present the design of a framework called Contextion for easily creating context-aware mobile applications. The framework is built as a layered architecture in order for portions of application components to be adapted based on current contextual information. Contextion also allows for rapid addition of new sensor technologies on a mobile device to the Contextion framework. Using a specification language, end-users can define in what situations various pieces of contextual data should be used and how the data affects the mobile application. In addition, the design of Contextion allows for the definition of operations based on contexts that may not be known at the time of development.
Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors

The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs) comprises three proteins – p21Cip1/WAF1, p27Kip1, and p57Kip2 – that bind and inhibit cyclin–CDK complexes, which are key regulators of the cell cycle. CIP/KIP CKIs have additional independent functions in regulating transcription, apoptosis and actin cytoskeletal dynamics. These divergent functions are performed in distinct cellular compartments and contribute to the seemingly contradictory observation that the CKIs can both suppress and promote cancer. Multiple ubiquitin ligases (E3s) direct the proteasome-mediated degradation of p21, p27 and p57. This review analyzes recent data highlighting our current understanding of how distinct E3 pathways regulate subpopulations of the CKIs to control their diverse functions.
Proximal Femoral Replacement in the Management of Acute Periprosthetic Fractures of the Hip: A Competing Risks Survival Analysis

Abstract To examine the mortality and implant survivorship of proximal femoral replacement (PFR), revision total hip arthroplasty (REV) and open reduction internal fixation (ORIF) in the treatment of acute periprosthetic fractures of the proximal femur, we retrospectively reviewed 97 consecutive acute periprosthetic proximal femoral fractures from 2000 to 2010. Three groups were defined: PFR (n=21), REV (n=19), and ORIF (n=57). Outcome measures were all-cause mortality, implant failure, and reoperation. Competing Risks survival analysis of overall mortality during the mean 35-month follow-up showed no statistical difference between the three groups ( P =0.65; 12 and 60month mortality for PFR: 37%, 45%; REV: 16%, 46%; ORIF: 14%, 100%). Implant survival was worse for the PFR group ( P =0.03, 12 and 60-month implant failure rate for PFR: 5%, 39%; REV: 7%, 7%; ORIF 2%, 2%). We conclude that PFR as compared with REV or ORIF may have worse medium-term implant survival, primarily due to instability and dislocation.
The Aesthetics of Public Visibility: Alevi Semah and the Paradoxes of Pluralism in Turkey

Efforts to theorize pluralism have often explored the challenges posed by the public visibility of ethnic, linguistic, and sectarian differences to modernist imaginaries of a homogeneous national body. In this essay, I examine a context in which public expressions of communal differences re-inscribe the categories of the nation they were meant to contest. The situation reveals what I call a paradox of pluralism.
Symptomatic Bipartite Medial Cuneiform Treated with Fluoroscopic and Ultrasound-Guided Injections:

The bipartite medial cuneiform (BMC) is a rare congenital variant that was first described by Morel in the 18th century [2, 6]. Amongst the many causes of midfoot pain, BMC is primarily an imaging diagnosis that often depends on plain radiographs as the initial diagnostic test. Recognizing a BMC on radiographs can be difficult as the osseous segments are typically well corticated and blend with the remainder of the tarsal bones. Additionally, although there are many fracture patterns at the tarsometatarsal (TMT) joint level including Lisfranc injuries, the cleft between the osseous segments lies in the horizontal plane in contrast to the typical vertical orientation of isolated fractures through the medial cuneiform [9]. The cleft is formed by a pseudoarticulation between the osseous segments. Symptomatic patients typically present with chronic midfoot pain that is exacerbated with ambulation or acute injury typically due to the inherent instability of the pseudoarticulation resulting in stress response and/or degeneration. When a BMC is symptomatic, treatment has ranged from nonoperative to surgical interventions including fusion and excision, as well as a previously described computed tomography (CT)-guided corticosteroid injection [3]. We believe our case is unique in that the patient underwent imaging using plain radiographs, CT, and magnetic resonance imaging (MRI) as well as successful image-guided injections using fluoroscopy and ultrasound on a bipartite medial cuneiform with a fibrous pseudoarticulation. The procedures and outcomes of minimally invasive fluoroscopic and ultrasound-guided steroid and anesthetic injections have not been previously described.
GaInP/GaAs collector-up tunnelling-collector heterojunction bipolar transistors with zero-offset and low-knee-voltage characteristics

Collector-up GaInP/GaAs heterojunction bipolar transistors with a 10 nm-thick GaInP tunnel layer, which prevents the flow of holes at the base-collector junction while allowing the electrons to flow, have been realised which have current-voltage characteristics with almost zero offset (5 to 10 mV) and a very small knee voltage of 0.34 V at 0.5 kA/cm2. These characteristics make the transistors attractive candidates for high-efficiency high power amplifiers.
Patterns of Residential Crowding among Hispanics in Later Life: Immigration, Assimilation, and Housing Market Factors

Objective. We describe patterns of residential crowding among older Hispanics and non-Hispanic Whites. We also examine hypotheses about the relationship of residential crowding with assimilation (language and duration of residence) and housing market characteristics. Methods. We employ a multilevel research design, using data from the 2000 U.S. Census of Population. Hierarchical linear models are utilized to estimate the association between residential crowding and both individual and housing market factors. Results. Approximately one third of older Hispanics in metropolitan areas live in crowded housing compared with only one tenth of older non-Hispanic Whites. Foreign-born older persons report higher levels of crowding than U.S.-born older persons. Residential crowding differences between older Hispanics and non-Hispanics are not eliminated after controls are included. Older Hispanics who report better English language skills and a longer duration of residence in the United States live in less crowded housing. We do not find evidence for a relationship between crowding and residential segregation, but we find consistent evidence for an association between residential crowding and relative size of the Hispanic population. Discussion. The forces that shape household composition and access to housing among older Hispanics appear to result in higher levels of residential crowding for this population.
A New Perspective on Entry in Horizontal Merger Analysis

I analyze horizontal mergers in procurement settings in which sellers incur costs to participate. Considering existing sellers’ contest-level entry differs from antitrust authorities’ typical emphasis on new sellers’ market-level entry to counteract a merger’s anticompetitive harm. I show that profitable mergers can increase consumer and total surplus by inducing more and stronger contest-level entry by the merged seller, which echoes common claims from merging parties that their merger is beneficial because it creates a stronger competitor. This finding suggests caution by antitrust authorities: when contest-level entry costs matter, standard models that ignore those costs prescribe blocking procompetitive mergers.
The Sorting Out Stress Cards—A Version of the SMQ

Abstract The primary purpose of this study was to develop and test reliability of the Sorting Out Stress (SOS) Cards, a shortened version of the Stress Management Questionnaire (SMQ) for use in identifying individual symptoms of stress, stressors, and copers. The SOS Card version of the SMQ consists of 52 descriptors. Items were selected for inclusion in the shortened version from the SMQ symptoms, stressors and copers based on their frequency as analyzed in previous research studies. Eighty participants, equally distributed between age categories 18–24, 24–44, 45–64, and 65+, were individually administered the SOS Cards. Twenty participants, 5 from each age category, were then randomly selected and each administered a retest of the SOS Cards approximately 2 weeks following initial testing. Data analysis was performed using congruence of agreements on test-retest reliability. A match or congruence of agreement was an item selected and ranked in the first test and selected and ranked in the retest. A concu...
Comparative effectiveness of first-line (1st) VEGF TKI followed by second-line (2nd) therapy with either a VEGF TKI or an mTOR inhibitor in patients (pts) with metastatic renal cell carcinoma (mRCC).

e15589 Background: In the INTORSECT trial, not progression-free (PFS), but overall survival (OS) was higher with sorafenib vs. temsirolimus in 2nd setting after 1st sunitinib therapy in mRCC pts. H...
Beyond Space and Time

Outstanding national achievements to the development of which higher education has contributed substantially are cited, among them being 1) attainment of a high standard of living based on scientific and technological accomplishments, 2) a high degree of social mobility, and 3) a high degree of political stability. Difficulties confronting colleges and universities in meeting greatly increased demands are examined in the light of developments which have deprived them of the priority of support they once enjoyed. It is contended that higher education must be adequately supported at whatever cost if immediate and future demands are to be satisfied.
P3-S2.02 Variations in testing and treatment received by infants with possible neonatal herpes

Background Data are scarce on clinical care of infants with possible neonatal herpes simplex virus (HSV) infection, a rare and serious condition that should be treated with systemic acyclovir for 14–21 days. We reviewed HSV testing and treatment in a large cohort of US infants in order to assess clinical care received. Methods We investigated >270 000 infants born from 1997 to 2002 at three managed care organizations participating in the US Vaccine Safety Datalink. Medical records were abstracted if an infant had a discharge ICD-9 code compatible with HSV infection, a positive laboratory test for HSV, or neonatal death. Abstracted data included symptoms, testing, and treatment. Two physicians reviewed likely HSV infections. We identified confirmed cases (compatible symptoms and positive laboratory test), probable cases (compatible symptoms only), and others (with an alternate diagnosis). Descriptive frequencies were calculated. Results We abstracted records from 770 infants, identifying 35 cases (24 confirmed and 11 probable) and 735 others. HSV infection manifested as skin, eye, and mucosal (SEM) disease in 20 cases, central nervous system (CNS) disease in 8 cases, and disseminated disease in seven cases. Among 35 cases, all 35 (100%) had symptoms compatible with HSV infection; these included vesicular lesions in 20 (57%) and seizure in 7 (20%). Overall, 35 (100%) were ever tested for HSV. At least 34 (97%) received some acyclovir; median time to treatment, available for 32 cases, was 3 days (range 0–35 days). Only 8 (23%) received systemic acyclovir for the recommended 14–21 days, while 18 (51%) received Conclusions Our results reveal variations in clinical care of infants with possible neonatal HSV infection. Among cases, duration of antiviral therapy rarely followed treatment recommendations. Among symptomatic infants, most with vesicular lesions but few with seizures were ever tested for HSV. These variations suggest opportunities for clinical quality improvements.
Henry James’s Emerging Subconscious and the Wandering Transatlantic Tourist: The Search for Artistic Freedom

With the publication of Roderick Hudson in Atlantic Monthly in 1875, Henry James anticipates the Freudian theory of the ego, super-ego and id. Through the impulse to create, James defines the will as the artist’s desire to achieve self-actualization. But this will is in conflict with society’s social mores and responsibilities. Consequently, the artist is doomed to a limbo world in which the will creates idealized representations of nature, without – like Pygmalion -- having the ability to bring his creation to life. In describing the aesthetic pleasures of visual perception, James tacitly acknowledges pioneering research in perceptual cognition and makes the transition to emerging psychological theories of the subconscious will and desire. James reevaluates the purpose of art in an increasingly commercialized society that depends upon aesthetics for its viable existence and cohesion without providing the tangible means of supporting the emerging artist.
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome in Older Adults.

Improved survival with combination antiretroviral therapy has led to a dramatic increase in the number of human immunodeficiency virus (HIV)-infected individuals 50 years of age or older such that by 2020 more than 50% of HIV-infected persons in the United States will be above this age. Recent studies confirm that antiretroviral therapy should be offered to all HIV-infected patients regardless of age, symptoms, CD4+ cell count, or HIV viral load. However, when compared with HIV-uninfected populations, even with suppression of measurable HIV replication, older individuals are at greater risk for cardiovascular disease, malignancies, liver disease, and other comorbidities.
Audio Contribution and Distribution Channels

This chapter deals with the transmission of high-quality audio by broadcasters prior to, or “upstream” of, actual broadcast—in other words, any point-to-point transmission of audio signals involved in the production of broadcast content.
Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in Different Zones

Abstract 639 Hematopoietic stem cells (HSCs) are maintained in a balance between quiescent state and proliferating state. While proliferating HSCs are critical for supporting the routine blood production, quiescent HSCs are essential for long term maintenance and can also be activated to replenish lost proliferating or active HSCs. How the different states of HSCs are regulated is a fundamental question. Accumulated evidence supports a model that quiescent HSCs are located in the endosteal zone and active HSCs are in the perivascular zone. The underlying signaling to regulate the quiescence and activation in different niches remains largely unknown. To address this question, we have analyzed the expression profile of Wnt receptors, Frizzleds, in HSCs. We found that noncanonical Wnt signaling via receptor Frizzled8 (Fz8) and co-receptor Flamingo presents in and functionally maintains quiescent HSCs in the endosteal zone (Sugimura, et al., Cell 2012). However, it has not been clear whether and how active HSCs in the perivascular zone are regulated by Wnt signaling. Recently, we detected that another noncanonical Wnt receptor, Frizzled5 (Fz5), is expressed in metabolically active (indicated by Mitotracker) HSCs and also in Nestin-GFP + mesenchymal stem cells (MSCs) in the perivascular zone of central marrow. Fz5 expresses neither in H2B-GFP label-retaining quiescent HSCs nor in endosteal cells and nor in sinusoidal cells as well. Using an Mx1-Cre:Fz5 knockout mouse model, we found a 60% decrease of HSCs isolated from central marrow, but no change in the number of HSCs isolated from endosteum. Functionally, hematopoietic reconstitution was not affected in the primary transplantation, but was substantially decreased (by 80%) in the secondary transplantation compared to the control. This indicates that Fz5 maintains HSCs in the perivascular zone. To examine the role of Fz5 in Nestin + MSCs for HSC maintenance, we examined the Nestin-Cre:Fz5 model. We observed a large loss of CD49 hi HSCs that were reported to represent intermediate (IT) HSCs. We further found a correlation of the quiescent vs. active HSCs respectively to long term (LT) HSCs vs. IT-HSCs with the latter population sensitive to 5FU treatment. Mechanistically we observed that Fz5 inactivation also led to a loss of Cdc42 polarity in the HSCs residing in the perivascular niche. The results suggest that Fz5-mediated noncanonical Wnt signaling regulates polarity of active HSCs in the perivascular zones. Future study is required to see whether the Fz5-Cdc42 mediated polarity in HSCs is associated with symmetric vs. asymmetric division. We propose that noncanonical Wnt signaling maintains quiescent and active HSCs reside respectively in the endosteal zone and the perivascular zone. In these zones, Fz8 and Fz5 are differentially expressed and mediate noncanonical Wnt signaling for HSC maintenance in the endosteal niche and to regulate active HSC action in the perivascular niche. Disclosures: No relevant conflicts of interest to declare.
dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.

Abstract We have isolated the Drosophila disc proliferation abnormal (dpa) gene, a member of the MCM family of DNA replication factors. Members of this family of proteins are required for DNA replication in yeast. A dpa null mutant dies during pupal stages because imaginal tissues necessary for the formation of the adult fly fail to proliferate normally. Beginning in late embryogenesis BrdU labeling reveals DNA replication defects in mitotically proliferating cells. In contrast, dpa is dispensable for endoreplication, a specialized cell cycle consisting of consecutive rounds of S phases without intervening mitosis. Our studies suggest an essential role for dpa in mitotic DNA replication but not in endoreplication. Thus, dpa is not a general replication factor but may play a specialized regulatory role in DNA replication.
Moral corruption in a climate of vulnerability: Assessing COP21

This chapter discusses the perfect moral storm of climate change. Climate change and its complexities, is arguably, the greatest challenge that humanity faces today. Using Stephen Gardiner’s analysis, this chapter presents the moral complexity of climate change and its ensuing intergenerational storm; it then discusses the moral content of the COP21 Paris Agreement; and finally, it suggests attitudinal change to address vulnerability and moral discord in dealing with the greatest challenge of our time.
Effect of transoral endoscopic adenoidectomy on peripheral blood T-lymphocyte subsets in children with obstructive sleep apnea-hypopnea syndrome and its treatment strategy

The objective of the present study was to investigate the effect of transoral endoscopic adenoidectomy on peripheral blood T lymphocyte subsets in pediatric patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its treatment strategy. Ninety-eight pediatric patients with adenoidal hypertrophy associated with OSAHS admitted to the Department of Otolaryngology, Xuzhou Children's Hospital were selected. After admission, patients received perfected 24 h polysomnogram monitoring, routine blood examination, fasting blood biochemistry examination, T-lymphocyte subset count, 24 h ambulatory blood pressure monitoring, and nasopharyngeal computed tomography. After patients were diagnosed with adenoidal hypertrophy associated with OSAHS, they underwent transoral endoscopic adenoidectomy with a power microdebrider. Patients were evaluated at 3-, 6- and 12-week follow-up visits. The CD3+, CD4+, and CD8+ T-cell counts, CD4+/CD8+ T lymphocyte ratio, and changes of 24 h ambulatory blood pressure before and after surgery were recorded. After the 6-week follow-up visit, the mean CD4+ T lymphocyte count in patients was increased significantly compared with that before surgery, the CD4+/CD8+ T lymphocyte ratio increased gradually, and the differences were statistically significant (P<0.05). The frequency of nocturnal awakening of patients was decreased significantly after surgery and the duration of nocturnal sleep was extended significantly (P<0.05). Through analysis of the preoperative and postoperative clinical data of pediatric patients, the CD4+/CD8+ T lymphocyte ratio was negatively correlated with mean arterial pressure (MAP) (r=-1.06, P=0.003). In conclusion, adenoidectomy can significantly decrease the MAP in pediatric patients with OSAHS and increase the duration of nocturnal sleep. The peripheral blood CD4+/CD8+ T lymphocyte ratio in pediatric patients was significantly negatively correlated with MAP.
The Contingent Effects of Fatherhood on Offending

A growing body of research assesses the relationship between fatherhood and desistance. Qualitative studies typically find fatherhood reduces offending, especially substance use; yet, quantitative studies have produced mixed findings. Guided by life-course theory, this study hypothesizes that fatherhood affects certain kinds of offending and fatherhood’s effects on offending are most pronounced among fathers who reside with their child. To test our hypotheses, NLSY97 data are employed along with fixed-effects regression analyses to estimate the relationship between fatherhood and offending, while controlling for time-varying and time-stable competing factors. Periods of fatherhood are associated with reductions in licit and illicit substance use but not other kinds of offending, and these effects are considerably stronger in periods in which fathers resided in the same household as their child. By contrast, residential fatherhood is associated with reductions in property offending and arrest. These results confirm the findings of qualitative research in that fatherhood, particularly residential fatherhood, reduces substance use but has weaker effects on other kinds of deviance.
2017 INTERNATIONAL ECG SCREENING CRITERIA APPLIED TO MRI-CONFIRMED CASES OF HYPERTROPHIC CARDIOMYOPATHY IN THE GENERAL POPULATION: A RETROSPECTIVE SINGLE CENTER PILOT STUDY

Hypertrophic cardiomyopathy (HCM) carries an increased risk for sudden cardiac death, and up to 6% of patients may have a normal ECG. 2017 International ECG criteria demonstrated significant increase in specificity for differential diagnosis between HCM and athletes heart with marginal decrease in
Modeling and simulation of cross-flow transport membrane condenser heat exchangers

Abstract Transport Membrane Condenser (TMC) is a promising technology that works based on the capillary condensation property of the nano-scale ceramic porous membrane materials and can recover both waste heat and water in various industrial applications. For applications with high volume flow rate such as in power plants, a large number of TMC heat exchangers are required, which highlights the importance of the optimum design for the TMC exchangers in order to obtain the maximum heat transfer and minimum cost of the TMC heat exchanger unit. In this paper, the effects of different tube spacing and the inlet water vapor mass fraction on the overall performance of a membrane-based heat exchanger have been studied numerically using a combined condensation model based on the capillary condensation and condensation on a solid wall. The results were obtained in terms of the Euler number, dimensionless volumetric heat transfer density, and contours of the water mass fraction and temperature distribution inside the TMC heat exchanger.
Loss of deep roots limits biogenic agents of soil development that are only partially restored by decades of forest regeneration

Roots and associated microbes generate acid-forming CO 2 and organic acids and accelerate mineral weathering deep within Earth’s critical zone (CZ). At the Calhoun CZ Observatory in the USA’s Southern Piedmont, we tested the hypothesis that deforestation-induced deep root losses reduce root- and microbially-mediated weathering agents well below maximum root density (to 5 m), and impart land-use legacies even after ~70 y of forest regeneration. In forested plots, root density declined with depth to 200 cm; in cultivated plots, roots approached zero at depths >70 cm. Below 70 cm, root densities in old-growth forests averaged 2.1 times those in regenerating forests. Modeled root distributions suggest declines in density with depth were steepest in agricultural plots, and least severe in old-growth forests. Root densities influenced biogeochemical environments in multiple ways. Microbial community composition varied with land use from surface horizons to 500 cm; relative abundance of root-associated bacteria was greater in old-growth soils than in regenerating forests, particularly at 100–150 cm. At 500 cm in old-growth forests, salt-extractable organic C (EOC), an organic acid proxy, was 8.8 and 12.5 times that in regenerating forest and agricultural soils, respectively. The proportion of soil organic carbon comprised of EOC was greater in old-growth forests (20.0 ± 2.6%) compared to regenerating forests (2.1 ± 1.1) and agricultural soils (1.9 ± 0.9%). Between 20 and 500 cm, [EOC] increased more with root density in old-growth relative to regenerating forests. At 300 cm, in situ growing season [CO2] was significantly greater in old-growth forests relative to regenerating forests and cultivated plots; at 300 and 500 cm, cultivated soil [CO2] was significantly lower than in forests. Microbially-respired δ13C-CO2 suggests that microbes may rely partially on crop residue even after ~70 y of forest regeneration. We assert that forest conversion to frequently disturbed ecosystems limits deep roots and reduces biotic generation of downward-propagating weathering agents.
Howler Monkeys and Harpy Eagles: A Communication Arms Race

Predation is considered by many researchers to be a selective pressure and strong evolutionary driving force in natural ecosystems. Predation phenomena are dynamic interactions that by definition need more than one agent: at least one predator and one prey. The interaction gets exponentially more complicated when we consider multiple agents and different strategies. These predator-prey interactions can be viewed as evolutionary arms races. There have been numerous studies on prey adaptations (Blumstein et al., 2000; Hauser & Caffrey, 1994; Marler et al., 1992; Endler, 1991; Cheney & Seyfarth, 1990; Hauser & Wrangham, 1990; Ryan et al., 1982), but few report both detailed adaptive responses to predation and ways predators can improve their killing efficiency (Berger et al., 2001). This lack of knowledge is even more striking for predation upon primates (Shultz et al., 2004; Gil-da-Costa et al., 2003; Zuberbuhler, 2000a; Zuberbuhler et al., 1999).
Style and Strategy: Snapshot Aesthetics in Brand Culture

Style and strategy inhabit different domains. Style generally remains the province of the humanities, whereas strategy occupies important positions within the applied social sciences, management in particular. Yet style forms a foundational element of strategic communication. Style helps organizations tell stories within recognizable genres. Style associates strategy with high culture. Style performs the brand. To provide a distinctive interdisciplinary perspective on strategy, I turn to particular styles as illustrative examples of how style intersects with organizational communication and informs strategy.
Agile methods fix software engineering course

This paper reviews one time through a revamped Software Engineering course which introduces Agile Methods, particularly pairs programming, to make better software and a more enjoyable experience. The paper discusses the structure of assignments, key points of the class environment, students' comments and improved performance over previous years. It is hoped that the reader will acquire at least a couple of ways to help students program better and like it more.
Breaking tradition: changing medical education to preserve the patient-doctor relationship.

Introduction to the November 2009 issue of Virtual Mentor on the topic of Humanizing Physician Learning. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.