cssi/SciSciGPT-SciSciNet huggingface dataset:
Beyond the Great Divide: Collaborative Networks and the Challenge to Dominant Conceptions of Creative Industries

○ The term 'creative industries' has different patterns of deployment. The main fault lines have traditionally appeared between the US, where the marketplace and consumer rule, and much of the rest of the world, where notions of the cultural public sphere and citizenship remain relevant (if under siege). But peer-to-peer (P2P) networks and open source software communities may offer an unexpected challenge to these two constructions. The realignment of the citizen/consumer divide, brought about by the blurring of producer/consumer relations and the requirements of citizenship in digitally enabled communities, holds the possibility for a redefined notion of creative industries.
Citric acid treatment of flax, cotton and blended nonwoven mats for copper ion absorption

The removal of metal ions from polluted water and wastewater with biodegradable, natural products is an area of current interest in the environmental arena. The objective of this study is to determine whether nonwoven mats made of biodegradable, natural fibers of flax and cotton can be used for remediation of a ubiquitous pollutant of water and wastewater, namely, copper ion. Nonwoven mats manufactured with flax or cotton fiber and flax/cotton fiber blends were treated with citric acid in order to enhance the amount of negative charge on the mats and improve their ability to sequester copper ion. The treated mats were monitored for changes in copper ion adsorption and fabric strength and compared to non-treated mats and process control mats. The results show that mats made from 100% flax and 75%/25% flax/cotton blends were similar to each other and significantly better at copper ion absorption than 100% cotton or 50%/50% flax/cotton blended nonwoven mats. Citric acid treatment, however, diminished mat strength compared to untreated mats for all samples; strength was similar for all treated nonwoven mats after correction for variable mat thickness. Treated flax fiber mats and flax/cotton fiber mats represent a potentially fast and convenient method for removal of metal ions from water and wastewater streams at an approximate cost of $1.40/m 2 of mat.
Feeding Preference of the Rio Grande Silvery Minnow (Hybognathus amarus)

The Rio Grande silvery minnow (Hybognathus amarus) was historically the most abundant fish in the Rio Grande Basin. However, populations have been declining to the point of being listed under the Endangered Species Act. Potential causes for the decline have been studied, yet little attention has been paid to food resources. This study had three objectives: (1) Determine whether larval fish show a substrate preference when foraging. (2) Determine whether larval fish have a diatom preference when presented with 15 diatom species over six feeding trials. (3) I investigated the possibility of training/conditioning H. amarus to feed on natural food sources (diatoms) and observe conditioning response (reaction time to feeding). I found no difference between substrate preference (p = 0.26). Results for feeding trials 1, 2, and 3 revealed a preference for Nitzschia palea (p < 0.01). Trial 4 revealed a preference for N. paleaformis (p < 0.01). Navicula veneta was the preferred diatom species in feeding trial 5. Nitzschia cf. intermedia was preferred in trial 6 (p < 0.03). Results from these feeding trials proved that H. amarus larvae learn quickly and can be trained to feed on diatom cultures after only one 30-min exposure. Pre-conditioned H. amarus arrived at diatoms cultures in 49 sec ± 39 sec compared to non-conditioned H. amarus, which arrived at diatom cultures at 250 sec ± 550 sec.
Slave Mothers and White Fathers: Defining Family and Status in Late Colonial Cuba

This paper outlines the mechanisms used to position the offspring of slave women and white men at various points within late nineteenth-century Cuba's racial hierarchy. The reproductive choices available to these parents allowed for small, but significant, transformations to the existing patterns of race and challenged the social separation that typically under girded African slavery in the Americas. As white men mated with black and mulatta women, they were critical agents in the initial determination of their children's status–as slave, free, mulatto, or even white. This definitional flexibility fostered an unintended corruption of the very meaning of whiteness. Similarly, through mating with white men, enslaved women exercised a degree of procreative choice, despite their subjugated condition. In acknowledging the range of rape, concubinage, and marriage exercised between slave women and white men, this paper highlights the important links between reproductive practices and the social construction of race.
Growth inhibition of MCF-7 and MCF-10A human breast cells by α-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs

The growth inhibitory properties of α-tocopheryl hemisuccinate (vitamin E succinate) and related compounds were examined in MCF-7 human breast tumor cells and MCF-10A normal-like human breast cells since they have been suggested to be an effective antitumor compound. The data showed that both α-tocopherol hemisuccinate and a structurally-similar compound, cholesteryl hemisuccinate, inhibited the growth of MCF-7 and MCF-10A cells, while α-tocopherol, cholesterol, cholesteryl sulfate and Tris succinate had little effect on cell growth. The ether analogs of the succinate esters, α-tocopheryloxybutyric acid and cholesteryloxybutyric acid, also inhibited growth of MCF-7 and MCF-10A cells, indicating that hydrolysis of the succinate esters by esterases is not required for the antiproliferative effects. The antiproliferative effects of these succinate esters and ethers may be related to their physiochemical properties that allow incorporation into cell membranes.
Mathematical Knowledge for Teaching in Planning and Evaluating Instruction: What Can Preservice Teachers Learn?

The goal of this study is to uncover the successes and challenges that preservice teachers are likely to experience as they unpack lesson-level mathematical learning goals (i.e., identify the subconcepts and subskills that feed into target learning goals). Unpacking learning goals is a form of specialized mathematical knowledge for teaching, an essential starting point for studying and improving one’s teaching. Thirty K–8 preservice teachers completed 4 written tasks. Each task specified a learning goal and then asked the preservice teachers to complete a teaching activity with this goal in mind. For example, preservice teachers were asked to evaluate whether a student’s responses to a series of mathematics problems showed understanding of decimal number addition. The results indicate that preservice teachers can identify mathematical subconcepts of learning goals in supportive contexts but do not spontaneously apply a strategy of unpacking learning goals to plan for, or evaluate, teaching and learning. Implications for preservice education are discussed.
“From Where I Sit”: Filipino Youth, Sexuality and Immigration in Participatory Action Research

Abstract Studies of young people9s experiences of sexuality rarely discuss how immigration and settlement impact youths9 understanding of their bodies, sexual identities, and knowledge. In this paper, Filipino youth in collaboration with adult allies, conducted a New York City-based participatory action research project and found that young people9s experiences and understanding of sexuality are narrated by silences, solidarity and paradoxical spaces. This study explores the contradictory experiences of passivity and subjectivity in the sexual lives of young people. Lastly, as an adult collaborator on the project I assess how “participation” as a logic of inquiry allows for youth and adult collaborators to talk through and negotiate their positions in a research project.
“I Use It Every Day”: Pathways to Adaptive Innovation After Graduate Study in Design Thinking

As the demand for creative and adaptive workers grows, universities strive to develop curricula that enable innovation. A pedagogical approach from the field of engineering and design, often called design thinking, is widely thought to foster creative ability; however, there is little research on how graduates of design thinking programs develop and demonstrate creative skills or dispositions. This chapter proposes a new model for the development of creative competence through design thinking education, and investigates alumni outcomes from a graduate school of design thinking. Quantitative and qualitative data from a survey (N = 175) and in-depth follow-up interviews (N = 16), indicate that alumni apply a range of design thinking methods and dispositions in their professional lives, particularly related to creative confidence, comfort with risk and failure, and building creative environments. We explore potential mechanisms by which students develop these capacities and foreshadow future analysis of obstacles to innovation in the workplace.
Low ER+ breast cancer: Is this a distinct group?

Objectives Estrogen receptor (ER) level can be semiquantified by immunohistochemistry (IHC) using the H-score. The score, given as the sum of the percent staining multiplied by the intensity level, ranges from 0 to 300. Methods Forty-nine ER+/HER2− invasive tumors with low ER expression (H-scores of 1–100, representing approximately 5% of all tumors) were studied for various morphologic parameters, progesterone receptor (PR), and Ki-67 IHC. Results Eighteen of 49 patients received neoadjuvant chemotherapy. The morphologic analysis showed that these tumors are often grade 3 and frequently demonstrate a sheet-like growth pattern, an intratumoral lymphocytic inflammatory infiltrate, and necrosis. Eighty percent of tumors showed a Ki-67 proliferation index of more than 50%, and 94% were PR−. Of the 18 patients who received neoadjuvant chemotherapy, six (33%) achieved pathologic complete response. Conclusions The low ER+/HER2− cases have morphologic features and a response to the chemotherapy rate that are more similar to triple-negative tumors than the usual type of ER+ tumors.
Investigation of West Nile virus carried by mosquito vectors in Guangdong province

Objective To study the community structure, dynamic and West Nile virus(WNV) carried of mosquito vectors in Guangdong, and provide scientific evidence for further development of control and prevention strategies.Methods Mosquito density was monitored by Light-trap from May 2013 to April 2014. One-step reverse-transcript PCR was applied.Results The average density of mosquito was 11.80/light. The seasonal peak of density was from May to July. Of all habitats the density in the barn was the highest. Culex pipiens quinquefasciatus accounts for 89.90%, the largest proportionof mosquitoes. No positive was found by RT- PCR.Conclusion Culex pipiens quinquefasciatus was the predominantspecies, the monitoring data could provide scientific basis for the control strategies and warning and forecasting of WNV,but the vectors species of West Nile fever in Guangdong province and its spread risk needs to be further studied.
Investigating the Interaction Pattern and Structural Elements of a Drug-Polymer Complex at the Molecular Level.

Strong associations between drug and polymeric carriers are expected to contribute to higher drug loading capacities and better physical stability of amorphous solid dispersions. However, molecular details of the interaction patterns and underlying mechanisms are still unclear. In the present study, a series of amorphous solid dispersions of clofazimine (CLF), an antileprosy drug, were prepared with different polymers by applying the solvent evaporation method. When using hypromellose phthalate (HPMCP) as the carrier, the amorphous solid dispersion system exhibits not only superior drug loading capacity (63% w/w) but also color change due to strong drug–polymer association. In order to further explain these experimental observations, the interaction between CLF and HPMCP was investigated in a nonpolar volatile solvent system (chloroform) prior to forming the solid dispersion. We observed significant UV/vis and 1H NMR spectral changes suggesting the protonation of CLF and formation of ion pairs between CLF...
W. Walker Chambers and John R. Wilkie, A Short History of the German Language

(1972). W. Walker Chambers and John R. Wilkie, A Short History of the German Language. The Germanic Review: Literature, Culture, Theory: Vol. 47, No. 1, pp. 76-78.
Sliding performance of machined grey cast iron surfaces after compliant abrasive surface polishing

Currently, linear sliding guideways are fabricated using machining centers for roughing and drilling while grinding machines are used for finishing operations. As a consequence, large and heavy machine tool castings must be transferred back and forth multiple times between the different equipment. In an effort to eliminate workpiece transfers and reduce production costs, an alternative manufacturing process that utilizes hard milling followed by fine-finishing with a spindle mounted abrasive filament tool is proposed. The goal of the current paper is to determine process settings for the filament tool optimized for sliding friction coefficients between PTFE slider and cast iron slideway. Areal function parameters Sk, Spk, Svk and load bearing ratio were used to evaluate the surface texture after polishing with various filament tools. A two-level partial factorial experiment with five factors was conducted friction coefficients were measured to calculate the significant main effects and second-order interactions. The dynamic sliding performances of five types of surfaces (ground, milled, milled + polished) were tested at sliding speeds from 80 to 2000 mm/s. It was found that the filament tools with the largest grit and thickest bristles have the greatest impact on surface quality, the alternative polishing method results in lower static and dynamic friction coefficients and the new process is not expected to increase machining time based on theoretical cycle time analysis.
OpenMEE : Intuitive, open-source software for meta-analysis in ecology and evolutionary biology

Summary Meta-analysis and meta-regression are statistical methods for synthesizing and modelling the results of different studies, and are critical research synthesis tools in ecology and evolutionary biology (E&E). However, many E&E researchers carry out meta-analyses using software that is limited in its statistical functionality and is not easily updatable. It is likely that these software limitations have slowed the uptake of new methods in E&E and limited the scope and quality of inferences from research syntheses. We developed OpenMEE: Open Meta-analyst for Ecology and Evolution to address the need for advanced, easy-to-use software for meta-analysis and meta-regression. OpenMEE has a cross-platform, easy-to-use graphical user interface (GUI) that gives E&E researchers access to the diverse and advanced statistical functionalities offered in R, without requiring knowledge of R programming. OpenMEE offers a suite of advanced meta-analysis and meta-regression methods for synthesizing continuous and categorical data, including meta-regression with multiple covariates and their interactions, phylogenetic analyses, and simple missing data imputation. OpenMEE also supports data importing and exporting, exploratory data analysis, graphing of data, and summary table generation. As intuitive, open-source, free software for advanced methods in meta-analysis, OpenMEE meets the current and pressing needs of the E&E community for teaching meta-analysis and conducting high-quality syntheses. Because OpenMEE's statistical components are written in R, new methods and packages can be rapidly incorporated into the software. To fully realize the potential of OpenMEE, we encourage community development with an aim to advance the capabilities of meta-analyses in E&E.
Audit Firm Reputational Consequences of Alleged Non-Accounting Misconduct by Clients

This study examines whether U.S. audit firms experience reputational damage when clients are accused of misconduct that does not affect auditor litigation risk. Auditors have minimal, if any, responsibility related to non-GAAP securities fraud class actions, our proxy for such misconduct, but bounded rationality suggests that auditors could still incur reputational damage from these suits. In the year after suit filing, fees are lower for the auditor’s clients in the same city-industry as the sued client, but are unchanged for clients of other auditors in the same city-industry. This effect is stronger (1) for new engagements, suggesting auditors must provide incremental discounts to win new clients, and (2) when suits are severe, likely because the negative information is more salient. Overall, these results provide evidence that reputation is an important incentive for U.S. audit firms. This study also contributes to mounting archival evidence of systematic biases and cognitive errors by corporate decision-makers.
Optimal Visual Search Elements in Small Scale Map Design

Empirically verifying improvements in information design has previously resulted in the effective redesign of visual information. We now seek which specific elements, such as color and symbols, optimize information comprehension in everyday applications such as a campus map (neutral coloration & numerically-represented). Through a series of maps and tasks, we were able to determine which combinations of elements provoked improved comprehension in speed and accuracy of response. Participants were given a fictional baseline map (neutral & numeric), either a newly-colored or symbolically-represented fictional map, and either the original or new campus map (new color & symbolization). They were then given the same conditions the next day in order to measure retention. It was found that color and symbols improved information comprehension separately, but not when incorporated in unison. There was also no significant difference between conditions regarding retention. Elements appear to improve information comprehension differently depending on the scenario.
Laboratory Studies of Jets in Rotating and Stratified Fluids

This communication discusses the importance of obtaining a deeper understanding of the interaction of jets having both lateral and vertical shear with complex topography in rotating and stratified fluid environments. The principal focus is on laboratory experiments for which source-sink methods for mechanically-generating such flows are discussed. The relevant geometric and dynamic similarity parameters for modeling atmospheric and oceanic flows are presented. Some examples of free jets (i.e., no topography) and jet interactions with isolated obstacles, in both homogeneous and linearly stratified fluids, are given.
Leg: Supine Position

The patient lying recumbent is the recommended position for examining two conditions. One is for determining a discrepancy in leg length. If discovered and addressed early in life, an insidious progression to unilateral disabling arthritis of the knees or hips decades later might be averted. The text contains a rapid assessment of this common anomaly of leg length.
Optimum PMU placement for power system state estimation

The integration of phasor measurement units (PMUs) in power grids can greatly enhance the robustness of power grid state estimations. Due to the cost of components and installations, the number of PMUs is usually much less than that of buses in a power system. Therefore one of the critical problems faced by power system design is PMU placement, that is, identifying the buses on which the PMU should be installed. The objective of this paper is to develop PMU placement algorithms to improve the power grid state estimation. Unlike many existing PMU placement algorithms developed based on the concept of critical measurements, we use the estimation mean squared error (MSE) as the design metric. By applying a linear minimum MSE (MMSE) algorithm, the MSE is expressed as an explicit function of the locations of the PMUs. The problem is formulated as a combinatorial optimization problem that is known to be NP-hard. To balance the tradeoff between complexity and performance, we propose two low complexity algorithms, a greedy algorithm that sequentially searches for the best PMU location, and a heuristic ordered MSE algorithm that places PMUs at buses with highest MSE. Simulation results show that the proposed low complexity algorithms can almost achieve the globally optimum performance, and they significantly outperform existing PMU placement algorithms.
Understanding the Black Teacher through Metaphor.

Teacher education scholars have long used the literary device of metaphor to describe the work of teachers. Metaphors offer colorful descriptions about the teacher and the profession of teaching. What also undergirds the use of metaphors about teaching is the underlying philosophies about the purpose of the teacher and teaching. We argue however, that race and culture inform the kind of metaphors one might use to describe the teacher . In this sense, racialized sociohistorical forces (Omi and Winant, Racial formation in the U.S., 3rd edn. Routledge, New York 2015) envelope the discourse of the teacher—particularly when deconstructing the metaphoric meaning of the “Black Teacher.” In this paper, we show how four metaphors took shape within historically situated contexts and have endured over time.
Oppositions 1973-1984

In 1973, from the rooms of the Institute for Architecture and Urban Studies (IAUS) of New York, came out the first issue of «Oppositions», a magazine intended to be, in the ’70s, an agent of radical transformations and a point of reference for US architectural culture that could generate a theoretical debate on architecture and its internationalization. Directing it from 1974 to 1982 was an editorial committee consisting of the American architect Peter Eisenman, the Argentine architect Mario Gandelsonas, and the English historian Kenneth Frampton. The committee was joined later by the historians Anthony Vidler and Kurt Forster.
Combined Tongue-Palate Fusion With Alveolar Bands in a Patient With Pierre Robin Sequence and Van der Woude Syndrome:

This report describes the presentation of a newborn male with circumferential tongue-palate fusion associated with cleft palate and alveolar bands. After intraoral adhesions lysis, the patient was ...
Globalization of Smaller Firms: Field Notes on Processes

Smaller firms have played a pivotal role in the present decade of globalization. Reduced barriers to international trade and investment coupled with the advances in information technology have accorded opportunities for smaller firms -- employing fewer than 500 persons -- to emerge as multinational. The focus of this exploratory paper is on the how of their globalization or internationalization. Information from field studies of seven firms -- three Dutch and four American -- obtained by means of personal interviews with senior managers constitutes the primary qualitative data. Considering the convenient choice of the firms and the subjective nature of the recall data the paper, without claiming to draw any inferences, offers three initial propositions, for further refinement, expansion and empirical testing.
Design and Installation Considerations of Dynamic Strain Gages for Thermo-Acoustic Aerospace Structures Test

Traditional polyamide film strain gages designed for high temperature applications have a survivable temperature threshold of 500–600 degrees F. Free-Filament (platinum) strain gages offer dynamic strain response with a temperature threshold up to 1800 degrees F. There are challenges using free-filament strain gages including providing robust installation methods, attachment leads, and signal conditioning. These factors are often overlooked and if not correctly addressed will give poor or incorrect responses. Standard adhesives and solder used to attach the strain gage and wire attachment leads break down at similar temperatures as polyamide film gages and are not well suited to use with free-filament gages. This paper will discuss ceramic flame spraying techniques using alumina or other high temperature bonding agents providing a robust and stable attachment. In addition, the use of, Nextel insulated, Constantan wire leads to withstand the high temperatures and direct radiation in high temperature dynamic testing environments will be addressed.
THE IS CORE - II: THE MATURING IS DISCIPLINE: INSTITUTIONALIZING OUR DOMAIN OF INQUIRY

Even though computerized information systems are a relatively recent phenomenon that continues to evolve, these technology-based systems are now studied by a maturing academic discipline. This article examines the issue of Information Systems (IS) core concepts; explores the content and boundaries of the Information Systems research domain; and discusses whether consensus about an identity and domain for Information Systems is important and worth discussing. Despite concerns in the profession about an IS identity crisis, Information Systems is a legitimate area of scientific research and inquiry. Groups like the Association for Information Systems are institutionalizing the IS domain of inquiry. Furthermore, Information Systems researchers are becoming much more assertive about the importance of the IS research domain.
Design of a simple functional programming language and environment for CS2

There are several advantages to introducing a functional language early in a student's college experience: it provides an excellent setting in which to explore recursively-defined functions and data structures, it encourages more abstract thinking, and it exposes students to a language paradigm that is likely quite different from their previous experience. Even in a core curriculum based on a traditional imperative (and object-oriented) language, it is valuable to spend two or three weeks investigating a functional language. However, we have found that most existing functional languages and environments pose significant hurdles to the introductory student, especially when the language is only being used for a short time. This paper discusses some of our ideas to simplify the framework, and allow students to experiment easily with the important concepts of functional programming in the setting of CS2.
Recent advances in Lynch syndrome

Lynch syndrome is one of the most common hereditary cancer predisposition syndromes and is associated with increased risks of colorectal and endometrial cancer, as well as multiple other cancer types. While the mechanism of mismatch repair deficiency and microsatellite instability and its role in Lynch-associated carcinogenesis has been known for some time, there have been significant advances recently in diagnostic testing and the understanding of the molecular pathogenesis of Lynch tumors. There is also an increased awareness that the clinical phenotype and cancer risk varies by specific mismatch repair mutation, which in turn has implications on surveillance strategies for patients. Even the treatment of Lynch-associated cancers has changed with the addition of immunotherapy for advanced disease. This progress report aims to review some of the many advances in epidemiology, molecular pathogenesis, diagnosis, clinical phenotype, cancer surveillance, treatment, and chemo- and immune-prevention strategies in the Lynch syndrome field over the past 5 years.
Functional cooperativity of p97 and histone deacetylase 6 in mediating DNA repair in mantle cell lymphoma cells

p97 is an ATPase that works in concert with histone deacetylase 6 (HDAC6), to facilitate the degradation of misfolded proteins by autophagosomes. p97 has also been implicated in DNA repair and maintaining genomic stability. In this study, we determined the effect of combined inhibition of p97 and HDAC6 activities in mantle cell lymphoma (MCL) cells. We report that treatment with p97 inhibitors induces dose-dependent apoptosis in MCL cells. The p97 inhibitor CB-5083 induces ER stress markers GRP78 and CHOP and results in the accumulation of polyubiquitylated proteins. Co-treatment with CB-5083 and the HDAC6 inhibitor ACY-1215 result in marked downregulation of CDK4, Cyclin D1, and BRCA1 levels without inhibiting autophagic flux. Consequently, treatment with CB-5083 accentuates DNA damage in response to treatment with ACY-1215 resulting in enhanced accumulation of H2AX-γ and synergistic apoptosis. Furthermore, ATM loss severely impairs phosphorylation of 53BP1 following co-treatment with CB-5083 and ACY-1215 in response to gamma irradiation. Finally, co-treatment CB-5083 and ACY-1215 results in reduced tumor volumes and improves survival in Z138C and Jeko-1 xenografts in NSG mice. These observations suggest that combined inhibition of p97 and HDAC6 abrogates resolution of proteotoxic stress and impairs DNA repair mechanisms in MCL cells.
Conversion of an Academic Health Sciences Library to a Near-Total Electronic Library: Part 1

In the last ten years, many health sciences libraries have gradually converted their collections from predominantly print journal subscriptions to electronic-only subscriptions. This is being driven by budget, space issues, and user preference. The desire to retain both the print and electronic versions of journal titles has proven to be unsustainable for many health sciences libraries in the face of flat or shrinking budgets and increased demand at the institutional level for space. Due to demand for space for a clinical simulation facility at the Pennsylvania State University College of Medicine, the George T. Harrell Health Sciences Library was faced with the need to accelerate the shift to primarily an electronic collection when more than 80% of the print journals and 20% of the print book collection were removed from the library. A case had to be made to the college administration that the older literature was still utilized and had value—and that it would be worthwhile to selectively purchase the el...
A Case Report of Massive Acetaminophen Poisoning Treated with a Novel “Triple Therapy”: N-Acetylcysteine, 4-Methylpyrazole, and Hemodialysis

Massive acetaminophen (N-acetyl-p-aminophenol; APAP) ingestion is characterized by a rapid onset of mitochondrial dysfunction, including metabolic acidosis, lactemia, and altered mental status without hepatotoxicity which may not respond to the standard doses of N-acetylcysteine (NAC). A 64-year-old woman without medical history presented comatose after an ingestion of 208 tablets of Tylenol PM™ (APAP 500 mg and diphenhydramine 25 mg). The initial APAP concentration measured 1,017 µg/mL (therapeutic range 10-30 µg/mL), and elevated anion gap metabolic acidosis, lactemia, and 5-oxoprolinemia were detected. High-dose intravenous (IV) NAC, 4-methylpyrazole (4-MP), and hemodialysis (HD) were initiated. She was transferred to a liver transplant center and continued both NAC and HD therapies until complete resolution of metabolic acidosis and coma without developing hepatitis. She was discharged without sequelae. This is the fourth highest APAP concentration recorded in a surviving patient. Moreover, this is the first report of a novel “triple therapy” using NAC, 4-MP, and HD in the setting of massive APAP ingestion that presents with coma, elevated anion gap metabolic acidosis, and lactemia. Emergency physicians should recognize these critically ill patients and consider high-dose NAC, 4-MP, and HD to be initiated in the emergency department (ED).
Giant Carotid Pseudoaneurysm Amenable to Pipeline Stenting in a Patient with Ehlers-Danlos Type IV (P6.221)

Objective: NA Background: A 24-year-old man with a history of Ehlers-Danlos Type IV with multiple vascular and bleeding complications presented after recurrent presyncopal episode. Patient was found to have dissection of bilateral internal carotid arteries (ICA) and right vertebral artery (VA). Left ICA pseudoaneurysm was found in the proximal cervical segment. Patient was stabilized as an inpatient and discharged with outpatient follow up scheduled in vascular neurology clinic. Follow up imaging showed growth of the left ICA pseundoaneurysm. Patient elected to have pipeline stenting of the left ICA pseudoaneurysm. The procedure was performed without complication. Patient was discharged on dual antiplatelet therapy. At 7 month follow up appointment patient noted no neurological deficits. Follow up diagnostic cerebral angiogram at 7 months documented near complete resolution of the pseudoaneurysm secondary to pipeline stenting. Design/Methods: This was a retrospective case report. Results: NA Conclusions: Although traditionally managed medically, our case report indicates that a carotid pseudoaneurysm may be successfully managed by stenting procedures. This procedure may be a useful option in patients who have contraindications to anticoagulation - the medical treatment for this problem. Disclosure: Dr. Senay has nothing to disclose. Dr. Nallami has nothing to disclose. Dr. Mazaris has nothing to disclose. Dr. Khan has nothing to disclose.
Efficacy and Safety of the Use of Pulmonary Arterial Hypertension Pharmacotherapy in Patients with Pulmonary Hypertension Secondary to Left Heart Disease: A Systematic Review

Pulmonary hypertension (PH) is often caused by left heart disease (LHD) such as heart failure (HF) or valvular heart disease. Historically, few randomized controlled trials have evaluated the off-label use of medications for treating pulmonary arterial hypertension (PAH) in patients with PH-LHD. However, multiple randomized controlled trials have been published over the last decade that investigated their use in patients with PH-LHD. In addition, recent updates in the classification and definitions of PH have led to an improved recognition of PH-LHD phenotypes, notably combined post-capillary and pre-capillary PH and isolated post-capillary PH. In this systematic review, we show that PAH medications should not be recommended in two distinct HF populations: patients with HF without definitive PH diagnosis and patients with isolated post-capillary PH due to HF. In addition, the use of bosentan or macitentan is not recommended in patients with combined post-capillary and pre-capillary PH due to HF, but sildenafil may be considered to improve pulmonary hemodynamics and exercise capacity in patients with combined post-capillary and pre-capillary PH due to HF. Riociguat 2 mg 3 times daily may also be considered to improve pulmonary hemodynamics in patients with combined post-capillary and pre-capillary PH due to heart failure with reduced ejection fraction but not heart failure with preserved ejection fraction. The postoperative use of sildenafil in the setting of PH after valvular heart disease intervention was evaluated. Limited clinical data and safety concern warrants caution with the postoperative use of sildenafil in patients with PH due to valvular heart disease. Despite recent advances in the understanding of PAH medications for patients with PH-LHD, uncertainty remains about their utility in distinct subgroups. Nonetheless, PAH pharmacotherapy should generally be avoided for most patients with PH-LHD.
The Occurrence and Concentration of Rare Earth Elements in Acid Mine Drainage and Treatment Byproducts. Part 2: Regional Survey of Northern and Central Appalachian Coal Basins

Many modern industries rely on rare earth elements (REEs) to produce products that are essential to both civil and defense applications. In a prior study (Vass et al., 2019), the authors showed that REE grades in acid mine drainage (AMD) and associated byproduct precipitates from AMD treatment (AMDp) warrant evaluation as a feedstock for REE production. The current work extends that effort through a broad survey of 141 AMD treatment sites in Northern and Central Appalachia. In this study, 185 raw AMD and 623 AMDp field samples were obtained and analyzed to assess the REE and major metal concentrations. Results show that an average of 282 μg/L and 724 g/tonne of REEs occur in AMD and AMDp respectively. Additionally, both basins contained similar distributions of REEs, and these distributions tended to favor heavy and critical REEs when compared with traditional REE ore deposits. Geospatial analysis identified a total resource of 340 tonnes stored at the 141 sites sampled in this study. While this analysis did not quantify the basin-wide REE inventory, it does indicate the impact that processing cut-off grades will have on the overall AMDp resource base.
Techno-economic analysis of geothermal system in residential building in Memphis, Tennessee

Abstract The residential building sector in the United States relies prolifically on electric cooling and natural gas heating, ventilating, and air conditioning systems. Technology advancement for more energy efficient and cost-effective energy systems is continuous, and a geothermal energy system is an attractive alternative to electricity and natural gas. This study investigates a simulated residential building in Memphis, Tennessee (TN) to assess the energy savings by replacing the existing electric/gas system with a geothermal heat pump system. Further, economics are considered to examine the payoff period and ultimate viability for geothermal technology in this region. EnergyPlus™, the U.S. Department of Energy (DOE) whole building simulation engine, analyzed a prototype home in Memphis, TN with this common utility system. City-specific ground characteristics are used to customize the ground heat exchanger and optimize result accuracy. Simulations reveal that replacing the existing system with a geothermal system accomplishes a 26% reduction in energy use. Our results prove an exciting alternative for homes in Memphis, TN to achieve abundant energy savings. Despite lower meter readings, a homeowner must consider initial capital investment and payoff period. This study provides city-customized payoff data by using local ground characteristics for design, location-specific home features, and regional plus federal incentive programs. Methods used within create a unique and accurate template procedure for identifying promising regions for residential geothermal systems throughout the broader United States.
Optimized trusted execution for hard real-time applications on COTS processors

While trusted execution environments (TEE) provide industry standard security and isolation, its implementation through secure monitor calls (SMC) attribute to large time overhead and weakened temporal predictability, potentially prohibiting the use of TEE in hard real-time systems. We propose super-TEEs, where multiple trusted execution sections are fused together to amortize TEE execution overhead and improve predictability through minimized I/O traffic and reduced switching between normal mode and TEE mode of execution. Super-TEEs may, however, violate a task's timing requirement and impact the schedulability of the system. We present a technique to enforce the correct timing requirement of a task, along with a sufficient test for schedulability in uniprocessors. We also, discuss ct-RM, a static task assignment and partitioned scheduling algorithm to schedule super-TEEs, alongside other real-time tasks, on multicore systems. Experimental results on a Raspberry Pi 3B, further confirmed by simulations, show that ct-RM outperforms the state-of-the-art technique in terms of usable utilization by 12% on average and up to 27%.
Β-Adrenergic Agonist Mediated Changes in Muscle Energy Metabolism in AMPKγ3 R200Q Pigs

ObjectivesThe β-adrenergic agonist Ractopamine (RAC) repartitions nutrients from adipose to skeletal muscle and enhances muscle accretion in a fast-fiber type specific manner. In contrast, muscles from pigs with a mutation in the key energy sensor, AMP-activated protein kinase (AMPK), exhibit a slower, more oxidative phenotype and elevated glycogen. Our objective was to utilize RAC and AMPK-mutated pigs to investigate the cellular signaling pathways regulating energy metabolism. Materials and MethodsAt approximately 90 kg, wild-type and AMPKγ3ᴿ²⁰⁰Q barrows (n = 29) were assigned to control diet or diet supplemented with RAC (9 ppm; Elanco Animal Health) for 28 d. Pigs were harvested and muscle was collected from the longissimus lumborum (LL) immediately after exsanguination (t = 0 min) and deep (red) and superficial (white) portions of the semitendinosus (RST and WST respectively) were collected at 15 min. Glycogen content and parameters of glycogen metabolism were analyzed, and muscle metabolic phenotype was assessed by measuring glycolytic and oxidative enzyme activities. ResultsRegardless of RAC or muscle, AMPKγ3ᴿ²⁰⁰Q increased glycogen (P < 0.001) and glycolytic potential (P < 0.001) compared to wild-type. In the LL, RAC decreased glycolytic potential in AMPK but not wild-type (genotype × diet, P < 0.05). Dietary RAC decreased glucose in RST and LL (P < 0.05) and WST (P = 0.08). The glycolytic capacity, indicated by lactate dehydrogenase activity, was differentially influenced by RAC and genotype in WST (genotype × diet, P < 0.02), whereas in the LL, lactate dehydrogenase was increased by RAC (P = 0.05). In contrast, oxidative capacity, assessed by citrate synthase activity, was increased (P < 0.001) in AMPK regardless of RAC in both LL and STW. ConclusionWhile AMPKγ3ᴿ²⁰⁰Q is associated with altered glycogen storage and a more oxidative metabolism, RAC administration affects muscle metabolic characteristics and alters metabolites toward glycolytic usage in a muscle specific manner. These results indicate that AMPK and RAC influence glycogen storage and energy metabolism, which may ultimately impact capacity for muscle growth.
Pragmatics in the Semantic Description of the Verbs of 'Giving'

The meaning of certain utterances is not entirely given by the interpretations of the syntactic and semantic features which are extracted from related linguistic structures. Rather, it is derived from the contexts of discourse in which these utterances are put to use. The verbs of 'giving' in Japanese represent exactly such a phenomena. I will discuss some of the intricate semantic characteristics of these verbs to show that their full description requires a set of pragmatic rules which can define the whole range of relevant contexts for the verbs of 'giving' and account for their meaning in these contexts. It will also be demonstrated that these rules of use will properly constitute part of the semantic description in as much as they can capture some linguistic insight which might be missed without consideration of the pragmatic elements in the context of discourse.
Acute Airway Management and Ventilation in the Neurocritical Care Unit

The depressant effects of an acute neurologic illness on airway, respiratory, and cardiovascular function can result in imminent peril to the patient and require expertise and judgment. However, airway management differs in that it also requires a range of manual skills. The emergence of new technology, principally video laryngoscopy, has improved intubation safety in the neurocritical care unit and has enhanced the skill set of intensivists. Recognizing a patient’s need for intubation, determining its urgency, and predicting its difficulty remain the critical first steps in airway management. Patients with evolving neurological injury and signs of airway compromise and respiratory insufficiency are vulnerable to acute deterioration for which intubation is often life-saving. Familiarity with intubating techniques and commonly used pharmacological agents for intubation and their hemodynamic and neurophysiologic effects is essential for maintenance of oxygenation and cardiovascular stability, management of intracranial pressure, avoidance of aspiration, and protection of the cervical spine. Overall level of respiratory support and choice of ventilator mode and settings should be chosen with both the patient’s respiratory physiology and neuropathology in mind. In this chapter we address the unique challenges of airway management in neurocritically ill patients, including general principles for the use of mechanical ventilation and a description of frequently employed ventilatory modes in this patient population.
Welcome to the IEEE Journal on Selected Areas in Information Theory (JSAIT)

I would like to warmly welcome our readers to this inaugural special issue of JSAIT, the Information Theory Society’s first new journal since the IRE Transactions on Information Theory launched in 1953. The society’s desire to expand its technical scope, incubate new research directions, catalyze connections with other disciplines, and highlight new and emerging applications formed the impetus for the new journal. To achieve these goals, JSAIT publishes special issues focusing on the intersections of information theory with fields such as machine learning, statistics, biology, finance, computer science, and physics. There will also be special issues for emerging topics of broad interest that are firmly within Information Theory. Each special issue will have at least one tutorial aimed to benefit people in our field and to forge connections with people in other fields that information theory has impacted or can impact.
An algorithm for an &#x1d4c1;2-homological test for the planarity of a graph

Given a finite simple graph Γ, one is able to define the presentation of an associate Coxeter group W(Γ) and construct a CW-complex on which the associated Coxeter group acts. The space is the so-c...
Comorbidities Associated with Granuloma Annulare: A Cross-Sectional, Case-Control Study.

Background: Granuloma annulare (GA) is a cutaneous granulomatous disorder of unknown etiology. There are conflicting data on the association between GA and multiple systemic conditions. As a result, we aimed to clarify the reported associations between GA and systemic conditions. Methods: A retrospective, cross-sectional, case-control study was performed in which the medical records of biopsy-confirmed GA patients ≥18 years of age, who presented to the Johns Hopkins Hospital System between 1 January 2009 and 1 June 2019, were reviewed. GA patients were compared to controls matched for age, race, and sex. Results: After adjusting for confounders, GA patients (n = 82) had higher odds of concurrent type II diabetes (odds ratio (OR) = 5.27; 95% confidence interval (CI), 1.73–16.07; p < 0.01), non-migraine headache (OR = 8.70; 95% CI, 1.61–46.88; p = 0.01), and a positive smoking history (OR = 1.93; 95% CI, 1.10–3.38; p = 0.02) compared to controls (n = 164). Among GA patients, women were more likely to have ophthalmic conditions (p = 0.04), and men were more likely to have cardiovascular disease (p < 0.01) and type II diabetes (p = 0.05). No differences in systemic condition associations were observed among GA subtypes. Conclusions: Our results support the reported association between GA and type II diabetes. Furthermore, our findings indicate that GA may be associated with cigarette smoking and non-migraine headache disorders.