cssi/SciSciGPT-SciSciNet huggingface dataset:
The Underpricing of Nature

At the heart of structural imbalance in the world economy is the underpricing of nature. In this chapter, we explore the factors underlying this pervasive problem. In particular, we focus on a key question: If natural and ecological capital are valuable sources of economic wealth, why are we squandering these assets? In addition, if ecological scarcity and natural capital depreciation are on the rise, why are we are we doing so little to address these problems?
Update on subaxial cervical trauma classification systems

Abstract Injury classification systems guide management, predict prognosis, and allow for communication between providers. Several classification systems for subaxial cervical trauma have been described. Historically, classifications focused on osseous morphology, inferred mechanism of action, and stability. Later, neurologic status of the patient and integrity of the posterior ligamentous complex were described as important determinants of treatment. This article will detail important historic classifications, the Subaxial Injury Classification (SLIC) and Severity Scale, and the novel AOSpine Subaxial Cervical Spine Injury Classification System.
The impact of resection method and patient factors on quality of life among stage IA non‐small cell lung cancer surgical patients

Background and Objectives Given the increased number of treatment options for stage IA lung cancer patients, there is a growing body of literature that focuses on comparing each option's relative impact on quality of life (QoL). The current study seeks to further understand the differences in these patients’ QoL according to surgical approach. Methods Screening-diagnosed first primary pathologic stage IA non-small-cell lung cancer surgical patients from the I-ELCAP cohort who answered a baseline and 1-year follow-up QoL questionnaire (SF-12) were included in the analysis. Thoracotomy patients (N = 85) were compared with VATS patients (N = 15) using paired t-tests and analysis of variance tests. Results Multivariate analyses indicated no differences in QoL change between the two groups from pre- to post-surgery. Physical and emotional role functioning significantly improved among VATS patients and worsened among thoracotomy patients. Among thoracotomy patients, a significant decrease in post-surgical physical QoL was observed only in those who underwent lobectomy (−3.3; 95% CI: −5.1,−1.5), not limited resection. Conclusions Although the sample size is small, preliminary findings underscore that changes in overall QoL are similar in VATS and thoracotomy stage IA lung cancer patients. Extension of the resection may be a more relevant factor on QoL post-surgery. J. Surg. Oncol. 2017;115:173–180. © 2016 Wiley Periodicals, Inc.
Young Adult Outcomes and the Life-Course Penalties of Parental Incarceration

Objectives:The transition to adulthood can be challenging, especially for children of incarcerated parents. Drawing on reentry and life-course scholarship, we argue that parental incarceration may adversely affect multiple life outcomes for children as they progress from adolescence into adulthood and that such effects may persist from early young adulthood into late young adulthood.Methods:The study uses propensity score matching analyses of National Longitudinal Study of Adolescent Health data (N = 12,844).Results:Analyses identified harmful effects of parental incarceration on many life domains, including criminal behavior, mental health, illegal drug use, education, earnings, and intimate relationships. These effects typically surfaced by early young adulthood and continued into late young adulthood.Conclusions:The results suggest that parental incarceration constitutes a significant turning point in the lives of young people and underscore the importance of life-course perspectives for understanding ...
Association of obstructive sleep apnea with adverse pregnancy-related outcomes in military hospitals.

Abstract Background Obstructive sleep apnea (OSA) is associated with significant morbidity and mortality in non-obstetrical and obstetrical patients. Objectives To estimate the prevalence of OSA and its relationship with pregnancy-related complications in a general obstetric population of Department of Defense beneficiaries receiving direct-care at military treatment facilities. Study design A retrospective cohort study of all women (N = 305,001) who gave birth at a military treatment facility from 2008 to 2014. OSA cases were randomly selected and matched on age (3:1 ratio) to non OSA cases. Multivariable logistic regression was used to examine the risks of adverse pregnancy outcomes (cesarean delivery, gestational diabetes, gestational hypertension, preeclampsia, postoperative wound complications, hospital stay greater than five days, acute renal failure, pulmonary edema, preterm delivery, poor fetal growth, and stillbirth) between pregnant women with and without a diagnosis of OSA. Cases were identified using ICD-9 codes, while controlling for demographics, obesity, and medical comorbidities associated with OSA and the outcomes of interest. Results We identified 266 cases of OSA (OSA rate = 8.7 per 10,000; increased from 6.4 to 9.9 per 10,000 from 2009 to 2013). OSA was associated with a higher odds of cesarean delivery (AOR,1.60; 95% CI, 1.06–2.40), gestational hypertension, (AOR, 2.46; 95% CI, 1.30–4.68), preeclampsia (AOR, 2.42; 95% CI, 1.43–4.09), and preterm delivery (AOR, 1.90; 95% CI, 1.09–3.30). Conclusions Obstructive sleep apnea is associated with adverse maternal and fetal outcomes.
Where Do Shareholder Gains in Hedge Fund Activism Come From? Evidence from Employee Pension Plans

We find that defined benefit employee pension plans of firms that are targets of hedge fund activism experience underfunding and their defined contribution plans experience reductions in employer contributions. Pension underfunding occurs due to reduced employer contributions to the plans, which target firms justify by increasing the assumed rates of returns on plan investments and the discount rate used to compute the present value of plan obligations. Despite tilting plan investments toward riskier assets, pension fund performance does not improve after activists target a firm. Our evidence suggests that shareholder wealth gains from activism are partly wealth transfers from employees.
Protein-Mediated Colloidal Assembly

Programmable colloidal assembly enables the creation of mesoscale materials in a bottom-up manner. Although DNA oligonucleotides have been used extensively as the programmable units in this paradigm, proteins, which exhibit more diverse modes of association and function, have not been widely used to direct colloidal assembly. Here we use protein–protein interactions to drive controlled aggregation of polystyrene microparticles, either through reversible coiled-coil interactions or through intermolecular isopeptide linkages. The sizes of the resulting aggregates are tunable and can be controlled by the concentration of immobilized surface proteins. Moreover, particles coated with different protein pairs undergo orthogonal assembly. We demonstrate that aggregates formed by association of coiled-coil proteins, in contrast to those linked by isopeptide bonds, are dispersed by treatment with chemical denaturants or soluble competing proteins. Finally, we show that protein–protein interactions can be used to as...
Neural Recording Front-End Design

High-quality neural recording lays the foundation of neuroscience research. The last two decades have witnessed remarkable advances in neural recording front-end design. However, there are two challenges remaining: the increasing bandwidth requirement for modern high-density microelectrode arrays, and the high dynamic range requirement in advanced low voltage and low power systems. This work investigates novel circuit and system designs to address these challenges. This chapter first introduces the characteristics of neural signals, summarizes the design specifications, reviews prior work, and analyzes the key design trade-offs. The design of a general–purpose low-noise neural amplifier is presented, followed by a novel pre-whitening front-end. The pre-whitening amplifier design takes advantage of neural signal’s frequency characteristic. It significantly reduces the dynamic range requirement of the neural amplifier and the ADC resolution without sacrificing the signal quality. A 10-bit SAR ADC is designed for neural signal digitization. In addition, compressed sensing is used to reduce the wireless data rate. Compressed sensing is a signal processing technique that enables sub-Nyquist sampling and near lossless reconstruction of a signal with sparsity in a certain domain, including neural signals. The proposed system has been successfully used in animal experiments for long-term recording, which will be presented in this chapter.
Hepatic Adenomas: Classification, Controversies, and Consensus

Rapid advances in molecular and anatomic pathology have greatly improved our understanding of hepatocellular adenomas. Principle among them is a clinically relevant, histology-based classification that identifies hepatic adenomas at greatest risk for malignant transformation. This new classification system has led to general consensus on the major subtypes of hepatic adenomas. However, controversy remains regarding how to incorporate less common types of hepatic adenomas into the classification system and how to incorporate adenoma subtyping into clinical care. This article provides an in-depth review of how adenomas are classified, with a focus on the current rationale, the consensus, and controversies.
Arithmetic of 3 and 4 Branch Point Covers

The method of choice nowadays for achieving a group G as a Galois group of a regular extension of Q(x) goes under the heading of rigidity. It works essentially, only, to produce Galois extensions of Q(x) ramified over 3 points. The three rigidity conditions ((0.1) below) imply that G is generated in a very special way by two elements. Generalization of rigidity that considers extensions with any number r of branch points has been around even longer than rigidity (§5.1). Of the three conditions, the generalization of the transitivity condition, 0.1 c), requires only the addition of an action of the Hurwitz monodromy group H r (a quotient of the Artin braid group). But it also adds a 4th condition that in many situations amounts to asking for a Q-point on the Hurwitz space associated the data for the generators of G. Theorem 1 below -our main theorem- is that in the case r = 4 this is equivalent to finding a Q-point on a curve derived from a quotient of the upper half plane by a subgroup of PSL2(ℤ).
Evaluation of Chebyshev pseudospectral methods for third order differential equations

When the standard Chebyshev collocation method is used to solve a third order differential equation with one Neumann boundary condition and two Dirichlet boundary conditions, the resulting differentiation matrix has spurious positive eigenvalues and extreme eigenvalue already reaching O(N 5 for N = 64. Stable time-steps are therefore very small in this case. A matrix operator with better stability properties is obtained by using the modified Chebyshev collocation method, introduced by Kosloff and Tal Ezer [3]. By a correct choice of mapping and implementation of the Neumann boundary condition, the matrix operator has extreme eigenvalue less than O(N 4. The pseudospectral and modified pseudospectral methods are implemented for the solution of one-dimensional third-order partial differential equations and the accuracy of the solutions compared with those by finite difference techniques. The comparison verifies the stability analysis and the modified method allows larger time-steps. Moreover, to obtain the accuracy of the pseudospectral method the finite difference methods are substantially more expensive. Also, for the small N tested, N ⩽ 16, the modified pseudospectral method cannot compete with the standard approach.
Experimental comparison of initiation of motion for submerged objects resting on fixed permeable and impermeable beds

Laboratory experiments suggest a larger Shields parameter value requirement to initiate motion on permeable beds than on impermeable ones, which is connected with the lower lift force on a permeable bed.
Learning Low-Dimensional Metrics

This paper investigates the theoretical foundations of metric learning, focused on three key questions that are not fully addressed in prior work: 1) we consider learning general low-dimensional (low-rank) metrics as well as sparse metrics;2) we develop upper and lower (minimax) bounds on the generalization error; 3)we quantify the sample complexity of metric learning in terms of the dimension of the feature space and the dimension/rank of the underlying metric; 4) we also bound the accuracy of the learned metric relative to the underlying true generative metric. All the results involve novel mathematical approaches to the metric learning problem, and also shed new light on the special case of ordinal embedding (aka non-metric multidimensional scaling).
Use of Longitudinal Vibration and Visual Characteristics to Predict Mechanical Properties of No. 2 Southern Pine 2 × 8 and 2 × 10 Lumber

The objective of this study was to evaluate the accuracy of single MOE and MOR and combined mechanical properties with visual characteristics to improve the prediction of 2 x 8 and 2 x 10 No. @ southern pine lumber. This study evaluated the following variables: nondestructive tests, knots (knot diameter ratio [KDR] and knot area ratio), density, and mechanical properties (stiffness [MOE] and strength [MOR]). A total of 486 pieces were used, and linear regression models were constructed using stepwise selects to determine the best variables to estimate the MOE and MOR of southern pine lumber. The best single predictor for MOE and MOR was dynamic MOE (dMOE) followed by density. Among the two knot measurement methods used, the KDR best predicted stiffness and strength. For predicting the MOE, the variables dMOE, density, and KDR. The results showed that the addition of knot measurements to the models is able to improve the prediction of mechanical properties.
Traumatic brain injury broadly affects GABAergic signaling in dentate gyrus granule cells

Traumatic brain injury (TBI) causes cellular and molecular alterations that contribute to neuropsychiatric disease and epilepsy. GABAergic dysfunction figures prominently in the pathophysiology of TBI, yet the effects of TBI on tonic inhibition in hippocampus remain uncertain. We used a mouse model of severe TBI (controlled cortical impact, CCI) to investigate GABAergic signaling in dentate gyrus granule cells (DGGCs). Basal tonic GABA currents were not affected by CCI. However, tonic currents induced by the δ subunit-selective GABAA receptor agonist THIP (10 µM) were reduced by 44% in DGGCs ipsilateral to CCI (CCI-ipsi), but not in contralateral DGGCs. Reduced THIP currents were apparent 1 week after injury and persisted up to 15 weeks. The frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) was reduced in CCI-ipsi cells, but the amplitude and kinetics of sIPSCs were unaffected. Immunohistochemical analysis showed reduced expression of GABAA receptor δ subunits and GABAB receptor B2 subunits after CCI, by 43% and 40%, respectively. Activation of postsynaptic GABAB receptors caused a 2-fold increase in tonic currents, and this effect was markedly attenuated in CCI-ipsi cells (92% reduction). GABAB receptor-activated K+ currents in DGGCs were also significantly reduced in CCI-ipsi cells, confirming a functional deficit of GABAB receptors after CCI. Results indicate broad disruption of GABAergic signaling in DGGCs after CCI, with deficits in both phasic and tonic inhibition and GABAB receptor function. These changes are predicted to disrupt operation of hippocampal networks and contribute to sequelae of severe TBI, including epilepsy. Significance statement Traumatic brain injury (TBI) causes cellular and molecular changes that contribute to the clinical sequelae of TBI, including epilepsy, cognitive deficits, and mood disorders. Improved understanding of these cellular and molecular changes will inform therapeutic approaches to potentially disrupt epileptogenesis and treat symptoms. We investigated changes in GABAergic signaling of dentate gyrus granule cells (DGGCs) in a preclinical model of severe TBI (controlled cortical impact) and identified early and persistent deficits in expression and function of both synaptic and extrasynaptic GABAA receptors and GABAB receptors. These broad changes in GABAergic signaling will alter function of DGGCs and are predicted to perturb hippocampal networks and contribute to epileptogenesis and cognitive deficits after TBI.
Marine Terminal Operating Systems

Operating inefficiency begets the opportunity for technology to provide cost‐effective fixes. That, in a nutshell, is the compelling case that vendors of terminal operating system (TOS) software are making to managers of marine terminals, a critical chokepoint in the transportation networks. A TOS is a digital system that can integrate communication across a marine terminal – from vessel to gate and enhance operational efficiency. TOS vendors have a receptive audience because competing terminal managers yearn for a cost‐effective “solution” to increase their efficiency, which should translate into increased revenue and profit. The challenge is magnified because cargo handling operations at the marine terminal address the overlapping and sometimes conflicting interests of a myriad of players: carriers, shippers, consignees, and their agents. This chapter puts into context the evolution of delay‐related challenges marine terminals face and how the niche market software can help mitigate them. The chapter also highlights key vendors, issues plaguing the adoption of a TOS, and the evolution of TOS in the Industry 4.0 era.
Reducing Superfluous Opioid Prescribing Practices After Brain Surgery: It Is Time to Talk About Drugs

BACKGROUND Opioids are prescribed routinely after cranial surgery despite a paucity of evidence regarding the optimal quantity needed. Overprescribing may adversely contribute to opioid abuse, chronic use, and diversion. OBJECTIVE To evaluate the effectiveness of a system-wide campaign to reduce opioid prescribing excess while maintaining adequate analgesia. METHODS A retrospective cohort study of patients undergoing a craniotomy for tumor resection with home disposition before and after a 2-mo educational intervention was completed. The educational initiative was composed of directed didactic seminars targeting senior staff, residents, and advanced practice providers. Opioid prescribing patterns were then assessed for patients discharged before and after the intervention period. RESULTS A total of 203 patients were discharged home following a craniotomy for tumor resection during the study period: 98 who underwent surgery prior to the educational interventions compared to 105 patients treated post-intervention. Following a 2-mo educational period, the quantity of opioids prescribed decreased by 52% (median morphine milligram equivalent per day [interquartile range], 32.1 [16.1, 64.3] vs 15.4 [0, 32.9], P < .001). Refill requests also decreased by 56% (17% vs 8%, P = .027) despite both groups having similar baseline characteristics. There was no increase in pain scores at outpatient follow-up (1.23 vs 0.85, P = .105). CONCLUSION A dramatic reduction in opioids prescribed was achieved without affecting refill requests, patient satisfaction, or perceived analgesia. The use of targeted didactic education to safely improve opioid prescribing following intracranial surgery uniquely highlights the ability of simple, evidence-based interventions to impact clinical decision making, lessen potential patient harm, and address national public health concerns.
Dual trajectories of parenting self-efficacy and depressive symptoms in new, postpartum mothers and socioemotional adjustment in early childhood: A growth mixture model

Postpartum depression and low parental self-efficacy (PSE) are risk factors for poor child behavior. Little is known, however, about the course of dual trajectories of cooccurring depressive symptoms and PSE or its impact on children's socioemotional development. This study sought to identify trajectories of postpartum PSE and depressive symptoms in new, first-time mothers using growth mixture modeling. Results demonstrated a class of women with "low risk" (88.8%) who manifested low levels of depression and high levels of PSE during the postpartum period; a second group of women, labeled "early risk" (6.3%) with high levels of depression that decreased over time but lower levels of PSE that remained fairly stable; and a final trajectory group deemed the "late-risk" class (4.9%) with initially low levels of depression and high levels of PSE that significantly increased and decreased, respectively, over the period. Early childhood trauma, parenting stress, and poor parenting practices were associated membership in a high-risk class. Mothers in the high-risk groups reported children with more aggressive and defiant behavior at age 3. We conclude by discussing the implications of our findings for developing effective and sensitive interventions.
Mathematical estimation of half-value layer thicknesses.

Objective The objective of this article is to introduce a simplified and swift method to satisfactorily estimate the half-value layers (HVL), quarter-value layer (QVL), and tenth-value layer (TVL) from the x-ray spectra emitted by any diagnostic radiology or kV radiotherapy x-ray tubes. Methods A CdTe x-ray and Gamma detector (X-123 CdTe, AmpTek Inc.) is used to measure the x-ray spectra at four different x-ray energies (low, mid, high energy x-rays) with different external filtering. The software "SpekCalc GUI" (Developed in McGill University, Montreal, Canada) is also used to obtain the simulated x-ray spectra. Both measured and simulated spectra are used to compute the HVL thicknesses of Aluminum by a mathematical method presented in this article. Next, the HVL thicknesses for corresponding tube potentials are also measured by calibrated ionization chamber and varying thicknesses of aluminum plates. Finally, the computed and measured HVL, QVL, and TVL thicknesses are compared to evaluate the efficacy of the presented method. Results The results show acceptable concordance between computed and measured quantities. The disagreement rates between measured HVL and the values derived mathematically from the x-ray spectra are 10 to 90 micrometers of Aluminum at tube potentials of 31 kV to 120 kV. As it is shown, a negligible discrepancy is observed between the analytical estimation and the experimental assessments. Conclusion The HVL is an essential component in the evaluation of the quality of an x-ray beam. However, its measurement could occasionally be challenging, time-consuming, or uncertain due to some technical difficulties. Although the scope of this study is not to undermine the value of conventional and widely accepted practice to determine the HVL thickness, the introduced method provides the fast, more convenient, and comparably reliable technique to estimate the HVL, QVL, and TVL by employing the given x-ray spectrum.
Utility of intraoperative neuromonitoring and outcomes of neurological complication in lower cervical and upper thoracic posterior-based three-column osteotomies for cervical deformity.

OBJECTIVE For severe and rigid adult cervical deformity, posterior-based three-column osteotomies (3COs) are warranted, but neurological complications are relatively high with such procedures. The performance measures of intraoperative neuromonitoring (IONM) during cervicothoracic 3CO have yet to be studied, and there remains a paucity of literature regarding the topic. Therefore, the authors of this study examined the performance of IONM in predicting new neurological weakness following lower cervical and upper thoracic 3CO. In addition, they report the 6-month, 1-year, and 2-year outcomes of patients who experienced new postoperative weakness. METHODS The authors performed a retrospective review of a single surgeon's experience from 2011 to 2018 with all patients who had undergone posterior-based 3CO in the lower cervical (C7) or upper thoracic (T1-4) spine. Medical and neuromonitoring records were independently reviewed. RESULTS A total of 56 patients were included in the analysis, 38 of whom had undergone pedicle subtraction osteotomy and 18 of whom had undergone vertebral column resection. The mean age was 61.6 years, and 41.1% of the patients were male. Among the study cohort, 66.1% were myelopathic and 33.9% had preoperative weakness. Mean blood loss was 1565.0 ml, and length of surgery was 315.9 minutes. Preoperative and postoperative measures assessed were cervical sagittal vertical axis (6.5 and 3.8 cm, respectively; p < 0.001), cervical lordosis (2.3° and -6.7°, p = 0.042), and T1 slope (48.6° and 35.8°, p < 0.001). The complication rate was 49.0%, and the new neurological deficit rate was 17.9%. When stratifying by osteotomy level, there were significantly higher rates of neurological deficits at C7 and T1: C7 (37.5%), T1 (44.4%), T2 (16.7%), T3 (14.3%), and T4 (0.0%; p = 0.042). Most new neurological weakness was the nerve root pattern rather than the spinal cord pattern. Overall, there were 16 IONM changes at any threshold: 14 at 50%, 8 at 75%, and 13 if only counting patients who did not return to baseline (RTB). Performance measures for the various thresholds were accuracy (73.2% to 77.8%), positive predictive value (25.0% to 46.2%), negative predictive value (81.3% to 88.1%), sensitivity (18.2% to 54.5%), and specificity (77.8% to 86.7%). Sensitivity to detect a spinal cord pattern of weakness was 100% and 28.6% for a nerve root pattern of weakness. In patients with a new postoperative deficit, 22.2% were unchanged, 44.4% improved, and 33.3% had a RTB at the 2-year follow-up. CONCLUSIONS Complication rates are high following posterior 3CO for cervical deformity. 3CO at C7 and T1 has the highest rates of neurological deficit. Current IONM modalities have modest performance in predicting postoperative deficits, especially for nerve root neuropraxia. A large prospective multicenter study is warranted.
Finite Element Solution of Optimal Control Problems with Inequality Constraints

A temporal finite element method based on a weak Hamiltonian form of the necessary conditions is summarized for optimal control problems. Very crude shape functions (so simple that element numerical quadrature is not necessary) can be used to develop an efficient procedure for obtaining candidate solutions (i.e., those which satisfy all the necessary conditions) even for highly nonlinear problems. An extension of the formulation allowing for discontinuities in the states and derivatives of the states is given. Furthermore, the theory to include control inequality constraints is fully developed. Finally, an Advanced Launch Vehicle (ALV) model is presented. The model involves staging and control constraints, thus demonstrating the full power of the weak formulation to date. Numerical results are presented along with total elapsed computer time required to obtain the results. The speed and accuracy in obtaining the results make this method a strong candidate for a real-time guidance algorithm.
Elementary Theories with Models without Automorphisms

Publisher Summary This chapter discusses elementary theories with models without Automorphisms. According to Ehrenfeucht-Lauchli, a model M of an elementary theory T is called rigid if the identity function is the only automorphism of the model. It was shown in Ehrenfeucht-Mostowski that every theory T which has an infinite model has a non-rigid model in every infinite power m. the equivalence class which does not contain any individual constant has an “intrinsic automorphism”.
Peroxynitrite-Mediated Oxidation of d,l-Selenomethionine: Kinetics, Mechanism and the Role of Carbon Dioxide

Peroxynitrite oxidizes d,l-selenomethionine (MetSe) by two competing mechanisms, a one-electron oxidation that leads to ethylene and a two-electron oxidation that gives methionine selenoxide (MetSeO). Kinetic modeling of the experimental data suggests that both peroxynitrous acid and the peroxynitrite anion react with MetSe to form MetSeO with rate constants of 20,460 ± 440 M−1s−1 and 200 ± 170 M−1s−1, respectively at 25°C. The enthalpy (ΔH‡) and entropy (ΔS‡) of activation for the reaction of peroxynitrous acid with MetSe at pH 4.6 are 2.55 ± 0.08 kcal mol−1 and −30.5 ± 0.3 cal mol−1 K−1, respectively. With increasing concentrations of MetSe at pH 7.4, the yield of ethylene decreases and that of MetSeO increases, suggesting, as with methionine, the reactions leading to ethylene and MetSeO have different kinetic orders. We propose that the activated form of peroxynitrous acid, HOONO∗, is the one-electron oxidant and ground-state peroxynitrite is the two-electron oxidant in the reaction of peroxynitrite with MetSe. The peroxynitrite anion rapidly adds to CO2 to form an adduct, ONOOCO2− (1), capable of generating potent reactive species, and we therefore examined the role of CO2 in the peroxynitrite/MetSe system. In presence of added bicarbonate, the yield of ethylene obtained from the reaction of 0.4 mM peroxynitrite with 1.0 mM MetSe increases slightly with an increase in the concentration of bicarbonate from 0 to 5.0 mM and remains constant with a further increase of bicarbonate up to 20 mM. The yield of MetSeO, from the reaction of 10 mM peroxynitrite with 10 mM MetSe, decreases by 35% with an increase in the concentration of bicarbonate from 0 to 25 mM. Kinetic simulations show that the decrease in the yield of MetSeO is due to reaction of the peroxynitrite anion with CO2. These results suggest that CO2 partially protects MetSe from peroxynitrite-mediated oxidation and that 1 or its derivatives do not mediate the oxidation of MetSe to MetSeO.
Innovation and Patents

This chapter summarizes historical evidence on the link between patent laws and innovation. Earlier historical analyses have emphasized the importance of patent laws in encouraging innovation. Data on exhibits at international technology fairs, such as the 1851 Crystal Palace world’s fair, however, indicate that only a small share of innovations are patented and that non-patent mechanisms may play an important role in encouraging innovation. They also show that inventors’ dependency on patents varies strongly across industries, so that radical changes in patent laws may influence the direction if not the level of technical change. Exhibition data also indicate that patents may play an important role in facilitating encouraging the diffusion of innovative activity by encouraging inventors to advertise their ideas. These results highlight the need for additional analyses of innovation that systematically analyze patents and alternative measures of innovation.
Effect of adrenalectomy on Ca2+ signaling in rat hepatocytes

To pursue our studies of the effects of adrenalectomy on the adrenergic regulation of phosphorylase a, cAMP, cell calcium, and Ca2+ signaling in rat hepatocytes (Studer, R.K., and Borle, A.B. (1984) Biochim. Biophys. Acta 804, 377-385; Freudenrich, C.C., and Borle, A.B. (1988) J. Biol. Chem. 263, 8604-8610), we have further examined the alpha 1-adrenergic pathway in adrenalectomized and sham-operated male rats. We measured the number and affinity of alpha 1-adrenergic receptors, the cytosolic free Ca2+ concentration [(Ca2+]i) of hepatocytes with aequorin, inositol triphosphate (IP3) accumulation, and Ca2+ influx and efflux across the plasma membrane. We also compared the effects of vasopressin with those obtained with epinephrine. We found that the number of alpha 1-adrenergic receptors was slightly depressed (-23%), but that their affinity was unchanged. However, IP3 accumulation evoked by epinephrine was decreased 50%. This is probably the main cause for the depressed peak rise in [Ca2+]i we previously observed and reported. We also found that the basal resting Ca2+ influx was increased after adrenalectomy. Experiments with the beta-blocker propranolol, which abolished the epinephrine-evoked increase in Ca2+ influx, suggest that this effect may be mediated by cAMP, at least in adrenalectomized animals. The effects of vasopressin on IP3 [Ca2+]i and Ca2+ influx and efflux were also significantly decreased after adrenalectomy, indicating that alpha 1-adrenergic-mediated and other IP3-dependent Ca2+ signaling pathways are depressed after adrenalectomy.
Early and early disseminated phases of Lyme disease in the rhesus monkey: a model for infection in humans.

We demonstrate that Borrelia burgdorferi infection in the rhesus monkey mimics the early and early disseminated phases of human Lyme disease. Clinical, bacteriological, immunological, and pathological signs of infection were investigated during 13 weeks after inoculation of the spirochete. Three animals were given B. burgdorferi (strain JD1) by needle inoculations, six animals were exposed to the bite of B. burgdorferi-infected Ixodes dammini ticks, and three animals were uninfected controls. B. burgdorferi could be recovered from all animals that were given the spirochete. Bacteria were detectable until week 6 postinoculation (p.i.) in blood, until week 8 p.i. in skin biopsies, and at 10 weeks p.i. in the conjunctiva of one of two animals which developed conjunctivitis. Erythema migrans (EM) appeared in one of the three animals infected by needle inoculation and in five of the six animals infected by ticks. Deep dermal perivascular lymphocytic infiltrations (characteristic of human EM) were observed in all animals showing EM clinically. Both EM and conjunctivitis were documented concomitantly with the presence of the spirochete. Lethargy, splenomegaly, and cerebrospinal fluid pleocytosis were also noted in some animals, but the direct connection of these signs with the infection was not shown. The appearance rate of immunoglobulin M and immunoglobulin G antibodies to B. burgdorferi, as well as the antigen spectra recognized, were remarkably similar to those seen in humans. Serum antibodies from infected animals were able to kill B. burgdorferi in vitro in the presence of rhesus complement. The rhesus monkey model appears to be useful for the investigation of the immunology and pathogenesis of Lyme disease and for the development of immunoprophylactic, diagnostic, and chemotherapeutic protocols.
SU-E-J-214: MR Protocol Development to Visualize Sirius MRI Markers in Prostate Brachytherapy Patients for MR-Based Post-Implant Dosimetry

Purpose: The current CT-based post-implant dosimetry allows precise seed localization but limited anatomical delineation. Switching to MR-based post-implant dosimetry is confounded by imprecise seed localization. One approach is to place positive-contrast markers (Sirius) adjacent to the negative-contrast seeds. This patient study aims to assess the utility of a 3D fast spoiled gradient-recalled echo (FSPGR) sequence to visualize Sirius markers for post-implant dosimetry. Methods: MRI images were acquired in prostate implant patients (n=10) on Day 0 (day-of-implant) and Day 30. The post-implant MR protocol consisted of 3D T2-weighted fast-spin-echo (FSE), T2-weighted 2D-FSE (axial) and T1-weighted 2D-FSE (axial/sagittal/coronal). We incorporated a 3D-FSPGR sequence into the post-implant MR protocol to visualize the Sirius markers. Patients were scanned with different number-of-excitations (6, 8, 10), field-of-view (10cm, 14cm, 18cm), slice thickness (1mm, 0.8mm), flip angle (14 degrees, 20 degrees), bandwidth (122.070 Hz/pixel, 325.508 Hz/pixel, 390.625 Hz/pixel), phase encoding steps (160, 192, 224, 256), frequency-encoding direction (right/left, anterior/posterior), echo-time type (minimum-full, out-of-phase), field strength (1.5T, 3T), contrast (with, without), scanner vendor (Siemens, GE), coil (endorectal-coil only, endorectal-and-torso-coil, torsocoil only), endorectal-coil filling (30cc, 50cc) and endorectal-coil filling type (air, perfluorocarbon [PFC]). For post-implant dosimetric evaluation with greater anatomical detail, 3D-FSE images were fused with 3D-FSPGR images. For comparison with CT-based post-implant dosimetry, CT images were fused with 3D-FSPGR images. Results: The 3D-FSPGR sequence facilitated visualization of markers in patients. Marker visualization helped distinguish signal voids as seeds versus needle tracks for more definitive MR-based post-implant dosimetry. On the CT-MR fused images, the distance between the seed on CT to MR images was 3.2±1.6mm in patients with no endorectal coil, 2.3±0.8mm in patients with 30cc-PFC-filled endorectal-coil and 5.0±1.8mm in patients with 50cc-PFC-filled endorectal-coil. Conclusion: An MR protocol to visualize positive-contrast Sirius markers to assist in the identification of negative-contrast seeds was demonstrated. S Frank is a co-founder of C4 Imaging LLC, the manufacturer of the MRI markers.
Liver phenylalanine hydroxylase activity in relation to blood concentrations of tyrosine and phenylalanine in the rat.

The plasma concentration of phenylalanine and tyrosine decreases in normal rats during the first few postnatal days; subsequently, the concentration of phenylalanine remains more or less constant, whereas that of tyrosine exhibits a high peak on day 13. The basal concentrations of the two amino acids were not altered by injections of thyroxine or cortisol, except in 13-day-old rats, when an injection of cortisol decreased the concentration of tyrosine. In young rats (13–15 days old), treatment with cortisol increased the activity of phenylalanine hydroxylase in the liver (measured in vitro) and accelerated the metabolism of administered phenylalanine: the rate constant of the disappearance of phenylalanine from plasma and the initial increase in tyrosine in plasma correlated quantitatively with the activity of phenylalanine hydroxylase in the liver. In adult rats, the inhibition of this enzyme (attested by assay in vitro) by p-chlorophenylalanine resulted in a proportionate decrease in tyrosine formation from an injection of phenylalanine. However, the quantitative relationship between liver phenylalanine hydroxylase activity and phenylalanine metabolism within the group of young rats was different from that observed among adult rats.
Radioisotope tracer studies of inorganic carbon and Ca in microbially derived CaCO3

Abstract Microbial calcification significantly impacts the cycling and deposition of inorganic carbon. This research employs 45 Ca and 14 C techniques as radioisotopic tracers to examine the role of cellular cycling of Ca 2+ and inorganic carbon in CaCO 3 precipitation by the unicellular green alga Nannochloris atomus . Implications of the effects of these physiological aspects on CaCO 3 precipitation and the effects of microbial calcification on CaCO 3 δ 13 C ratios are discussed. Results from pulse/chase experiments indicate that intracellular Ca 2+ is incorporated into extracellular CaCO 3 . Intracellular inorganic carbon leaks from cells within 10 to 12 s after injection of unlabelled NaHCO 3 , providing a source of inorganic carbon for extracellular CaCO 3 . Cellular expulsion of calcium plays a key role in increasing the CaCO 3 saturation state at the site of calcification. The δ 13 C ratios of microbial carbonates may vary depending on the amount of photorespiratory CO 2 incorporated.
Alpha1-acid-glycoprotein protects against trauma-hemorrhagic shock.

Background Recent studies have shown that the acute phase protein α1-acid-glycoprotein (AAG) directly modifies endothelial cell responsiveness and is a crucial factor for maintaining endothelial barrier function. We hypothesized that the addition of AAG to the resuscitation fluid will prevent edema formation, increases circulating blood volume, and reduces tissue inflammation following soft tissue trauma and hemorrhagic shock.
De novo hepatocellular carcinoma in a hepatic allograft with recurrent hepatitis C cirrhosis

We report a case of de novo hepatocellular carcinoma (HCC) in a patient with recurrent hepatitis C (HCV) and cirrhosis 7 years after orthotopic liver transplantation (OLT). This is a previously unreported observation in the natural history of posttransplantantion HCV infection and reiterates the strong oncogenic potential of HCV.
Novel Protein Transduction Domain Mimics as Nonviral Delivery Vectors for siRNA Targeting NOTCH1 in Primary Human T cells

RNA interference technology has recently been highlighted as a powerful research method as well as a potential therapeutic treatment for several diseases. However, the delivery of small interfering RNA (siRNA) into T cell lines and primary blood cells is exceedingly challenging, as they are resistant to transfection by conventional reagents. As a result, there is an unmet need for nonviral, efficient, and easily prepared carriers for siRNA delivery into hard-to-transfect cell types. Here, we report a novel system based on protein transduction domain mimics (PTDMs), generated by ring opening metathesis polymerization, for intracellular delivery of siRNA molecules. PTDM-based siRNA delivery induced efficient NOTCH1 knockdown in Jurkat T cells and human peripheral blood mononuclear cells without any measured toxicity. Furthermore, delivering siRNA to NOTCH1 in human peripheral blood cells modulated cell proliferation and differentiation of T cells into TH1 cells.
Ethical problems special to surgery: surgical teaching, surgical innovation, and the surgeon in managed care.

This article will concern itself with 3 ethical challenges that are special to the role of the surgeon in our society. First is the teaching of surgery. This might be called "performing an operation for the first time (for the individual surgeon)." Second is surgical innovation. This might be termed "performing a new operation for the first time ever." The third ethical challenge is the role of the surgeon in managed care. This might be stated as "Can we trust corporations to provide all-risk coverage and freedom in clinical decisions?"
Sagebrush carbon allocation patterns and grasshopper nutrition: the influence of CO2 enrichment and soil mineral limitation.

Artemisia tridentata seedlings were grown under carbon dioxide concentrations of 350 and 650 μl l-1 and two levels of soil nutrition. In the high nutrient treatment, increasing CO2 led to a doubling of shoot mass, whereas nutrient limitation completely constrained the response to elevated CO2. Root biomass was unaffected by any treatment. Plant root/shoot ratios declined under carbon dioxide enrichment but increased under low nutrient availability, thus the ratio was apparently controlled by changes in carbon allocation to shoot mass alone. Growth under CO2 enrichment increased the starch concentrations of leaves grown under both nutrient regimes, while increased CO2 and low nutrient availability acted in concert to reduce leaf nitrogen concentration and water content. Carbon dioxide enrichment and soil nutrient limitation both acted to increase the balance of leaf storage carbohydrate versus nitrogen (C/N). The two treatment effects were significantly interactive in that nutrient limitation slightly reduced the C/N balance among the high-CO2 plants. Leaf volatile terpene concentration increased only in the nutrient limited plants and did not follow the overall increase in leaf C/N ratio. Grasshopper consumption was significantly greater on host leaves grown under CO2 enrichment but was reduced on leaves grown under low nutrient availability. An overall negative relationship of consumption versus leaf volatile concentration suggests that terpenes may have been one of several important leaf characteristics limiting consumption of the low nutrient hosts. Digestibility of host leaves grown under the high CO2 treatment was significantly increased and was related to high leaf starch content. Grasshopper growth efficiency (ECI) was significantly reduced by the nutrient limitation treatment but co-varied with leaf water content.
The effects of personal relevance of topic and information type on older adults' accurate recall of written medical passages about osteoarthritis.

Objectives:This study investigated the influence of information type (based on whether the text affirmed the reader’s veridical beliefs or disconfirmed the reader’s erroneous beliefs) and self-reported osteoarthritis status on older adults’ accurate recall of written medical passages about osteoarthritis. Methods:One week after reading the passages, adults aged 65 through 80 without osteoarthritis (n= 46) and with osteoarthritis (n= 31) completed a cued recall task that focused on accurate memory of what the passage said. Results:Disconfirming informationwas less accurately recalled than affirming information. Whereas self-reported osteoarthritis status was not significantly (p> .05) related to accurate recall of affirming information, it was significantly (p< .05) related to accurate recall of disconfirming information. Discussion:Older adults with osteoarthritis were more likely than older adults without osteoarthritis to misrepresent the content of the passages as supporting their misconceptions.
Management options for cavernous sinus meningiomas

Meningiomas involving the cavernous sinus have traditionally posed a major challenge for neurosurgeons and neuro-oncologists. Recent advancements in surgical techniques and radiotherapy have led to new treatment strategies for these difficult tumors. In this article, we review the current literature with respect to treatment options for cavernous sinus meningiomas. Additionally, we review the recent results of our experience at the University of Utah with decompression surgery followed by radiotherapy for cavernous sinus meningiomas.
Unobservable Heterogeneity and Rational Learning: Pool Specific vs. Generic Mortgage-Backed Security Prices

Previous mortgage prepayment and valuation models assume that two mortgage pools with the same observable characteristics should behave indistinguishably. However, pools with apparently identical characteristics often exhibit markedly different prepayment behavior. The sources of this heterogeneity may be unobservable, but we can infer information about a pool from its prepayment behavior over time. This paper develops a methodology for using this information to calculate pool-specific mortgage-backed security prices. Knowledge of pool-specific prices is important both for valuation purposes, and for determining the cheapest pool to deliver when selling mortgage-backed securities. This paper finds statistically significant heterogeneity between mortgage pools. It also finds that pool-specific prices, calculated for a sample of outwardly identical mortgage pools between 1983 and 1989, differ greatly, both from ``generic'' prices, and from each other.
Hydrostatic pressure changes in the abdomen of the hermit crabPagurus pollicarus during movement

1. The hermit crabPagurus pollicarus maintains an internal pressure of from 4 to 10 g/cm2 in its abdomen; this increases by two to 3 g/cm2 during lift of the shell and walking. 2. Characteristic pressure changes during flexion and extension are described; in addition, the response of pressure and motoneuron firing frequency is correlated during these movements. 3. The motoneurons of the ventral superficial muscles reponds to pressure changes in the abdomen with a long latency high threshold rapidly adapting response; it is concluded that this is due to stimulation of touch receptors in the skin. 4. There is no relationship between abdominal load and internal pressure. In addition, the slopes and intercepts of load-abdominal extension curves were not significantly different from each other over a range of imposed internal pressures ranging from zero to 24 g/cm2. It is concluded that pressure does not generate lift in the absence of changes in muscle tension.