cssi/SciSciGPT-SciSciNet huggingface dataset:
Who sleeps by whom? Parent-child involvement in urban Japanese families.

(1966). Who Sleeps by Whom? Parent-Child Involvement in Urban Japanese Families. Psychiatry: Vol. 29, No. 4, pp. 344-366.
Genetic factors potentially reducing fitness cost of organophosphate-insensitive acetylcholinesterase(s) in Rhipicephalus ( Boophilus ) microplus (Acari: Ixodidae)*

Acaricidal activity of organophosphate (OP) and carbamate acaricides is believed to result from inhibition of acetylcholinesterase (AChE). Previous studies in Rhipicephalus ( Boophilus ) microplus demonstrated the presence of three presumptive AChE genes ( BmAChE s). Biochemical characterization of recombinant BmAChE proteins expressed in the baculovirus system demonstrated that each of the three R . ( B .) microplus rBmAChEs have enzymatic properties consistent with designation as functional acetylcholinesterases. Complementary DNAs (cDNAs) for each of the three BmAChE s were cloned and sequenced from individual adult tick synganglia excised from OP-susceptible and OPresistant strains. The data revealed the presence of multiple transcript sequences within individual ticks for each of the BmAChE s, suggesting alternative mRNA splicing or expression of multiple alleles for each of the BmAChE genes. Quantitative real-time PCR provided evidence of possible gene duplication or amplification for each of the BmAChE genes, and direct sequencing of genomic DNA provided evidence of structural BmAChE gene diversity with respect to presence or absence of introns, as well as the presence or absence of sequence polymorphisms. Baculovirus expression of rBmAChE1 and rBmAChE3 proteins containing some of the predicted amino acid sequence polymorphisms resulted in production of OP-insensitive AChE, demonstrating that at least some OP-resistant individuals contain mutations that reduce OP-inhibition for at least two of the three known BmAChEs. RNA interference was utilized to silence in vivo expression of the BmAChE genes in adult ticks, resulting in tick mortality if all three BmAChEs were silenced simultaneously, strongly suggesting that the BmAChE proteins functionally complement one another in vivo . Together, the results presented provide strong evidence that OP-resistance in R . microplus is at least partially mediated by a combination of the expression of multiple genes encoding acetylcholinesterase, mutations in BmAChE s resulting in OP-insensitivity, gene duplication, and maintenance of allelic diversity, including both OP-sensitive and OPinsensitive alleles within individual ticks. The authors propose that these factors may mitigate fitness costs that might otherwise result from BmAChE mutations, and demonstrate the extreme complexity of OP-resistance in R . ( B .) microplus . It is hoped that elucidation of the complex interactions among the multiple BmAChEs and their physiological roles may enable development of new opportunities for tick control.
Experimental and computational investigation of vertical upflow condensation in a circular tube

Abstract This study explores the condensation of FC-72 in vertical upflow both experimentally and computationally. An axisymmetric 2-D computational model is used to predict variations of void fraction, condensation heat transfer coefficient, wall temperature and temperature profile across the liquid film. The computed results are shown to effectively capture the observed complex flow characteristics during flooding and climbing film conditions, including the annular film’s interfacial waviness, formation of liquid ligaments along the film’s interface, and breakup of liquid masses from these ligaments that are either re-deposited onto the film or entrained in the vapor core before moving towards the centerline. The model also shows good agreement with measured spatially averaged condensation heat transfer coefficients and wall temperatures. The predicted temperature profiles across the flow area successfully capture an appreciable temperature gradient at the liquid–vapor interface and saturation temperature in the vapor core.
Software power optimisation

Software can have significant impact on system energy consumption. Energy efficiency is one of the critical criteria when designing or evaluating software for embedded systems with limited energy supply. There are many optimisation techniques that can improve energy-efficiency of the software. This chapter has shown various examples of software that can be used to control power modes, enhance power modes, reconfigure resources for energy-efficiency. In addition, we also showed examples of how algorithm modifications and traditional compiler optimisations influence power consumption.
Nrf2 regulates the sensitivity of mouse keratinocytes to nitrogen mustard via multidrug resistance-associated protein 1 (Mrp1)

Sulfur mustard and nitrogen mustard (mechlorethamine, HN2) are potent vesicants developed as chemical warfare agents. These electrophilic, bifunctional alkylating agents cause skin injury, including inflammation, edema, and blistering. HN2 covalently modifies macromolecules such as DNA, RNA, and proteins or is scavenged by glutathione, forming adducts that can contribute to toxicity. Multidrug resistance-associated protein 1 (Mrp1/MRP1) is a transmembrane ATPase known to efflux glutathione-conjugated electrophiles. In the present studies, we examined the effects of modulating Mrp1-mediated transport activity on the sensitivity of primary and PAM212 mouse keratinocytes to HN2. Primary keratinocytes, and to a lesser extent, PAM212 cells, express Mrp1 mRNA and protein and possess Mrp1 functional activity, as measured by calcein efflux. Sulforaphane, an activator of Nrf2, increased Mrp1 mRNA, protein, and functional activity in primary keratinocytes and PAM212 cells and decreased their sensitivity to HN2-induced growth inhibition (IC(50) = 1.4 and 4.8 µM in primary keratinocytes and 1 and 13 µM in PAM212 cells, in the absence and presence of sulforaphane, respectively). The Mrp1 inhibitor, MK-571, reversed the effects of sulforaphane on HN2-induced growth inhibition in both primary keratinocytes and PAM212 cells. In primary keratinocytes from Nrf2(-/-) mice, sulforaphane had no impact on Mrp1 expression or activity, or on sensitivity to HN2, demonstrating that its effects depend on Nrf2. These data suggest that Mrp1-mediated efflux is important in regulating HN2-induced keratinocyte growth inhibition. Enhancing HN2 efflux from keratinocytes may represent a novel strategy for mitigating vesicant-induced cytotoxicity.
Starting from the Top: Using a Capstone Course to Begin Program Assessment in Legal Education

The purpose behind program assessment is simple: to improve student learning. If you improve your program, you in turn improve student learning. This should be every educator’s ultimate goal. The real question is not why you should assess your program — especially if the ultimate goal of the assessment is to improve student learning — but how you would get started actually doing it. Program assessment can be a daunting task. Inspired by our fictional student, Joe, we decided to start our legal writing program assessment at the top, beginning with our capstone course.Capstone courses have long been used in higher education for program assessment. Examining student work from a capstone course allows faculty to determine students’ strengths and weaknesses at the end of a program, when students can demonstrate cumulative learning, and such capstone work provides a comprehensive view of what students have learned throughout the program. In legal education, we propose that we can use our capstone course the same way. This Article presents how to begin the process of program assessment by using a capstone course. First, the Article describes the history of assessment generally. Second, the Article discusses the evolution of assessment in legal education specifically. Third, the Article provides a primer on assessment of student learning. Fourth, the Article presents the study we conducted on our capstone course and our findings. The Article concludes that using a capstone course is one model to begin program assessment. It is, however, just the tip of the iceberg.
[TRYPTOPHAN CONTENT OF THE CELLULAR ELEMENTS OF THE INTESTINE OF RATS AND GUINEA PIGS AFTER TOTAL-BODY ROENTGEN IRRADIATION].

1. Die eosinophilen Leukozyten der Darmwand bei Ratte und Meerschweinchen sind reich an Tryptophan (DMAB-Nitrit-Reaktion). 2. Orale Zufuhr von Tryptophan ist ohne Einflus auf den Tryptophangehalt der zellularen Elemente der Darmwand. 3. Bei einer Rontgen-Ganzkorperbestrahlung mit 600 r wandern nach 3 h eosinophile Leukozyten zwischen die Epithelzellen der Lieberkuhnschen Krypten ein. Dies geht mit Farbbarkeitsverlust der Granula einher. 4. Die Moglichkeit, das das Tryptophan der eosinophilen Leukozyten zur Serotoninsynthese in den enterochromaffinen Zellen dient, ist zu erwagen.
Cardiovascular effects of vasopressin following V1 receptor blockade compared to effects of nitroglycerin

Studies to more clearly determine the mechanisms associated with arginine vasopressin (AVP)-induced vasodilation were performed in normal subjects and in quadriplegic subjects with impaired efferen...
Ambivalence in Gay and Lesbian Family Relationships

Intergenerational ambivalence-the simultaneous presence of both positive and negative dimensions of a parent-child tie-is a concept widely used in family studies. Scholars have clarified the measurement of psychological ambivalence, or an individual's own feelings of ambivalence towards others. Yet research has yet to demonstrate whether-and, if so, how-individuals characterize others as ambivalent. Moreover, relatively little is known about ambivalence in gay and lesbian families. In the present study 60 in-depth interviews were analyzed to identify what the author calls perceived ambivalence in the parent, sibling, extended kin, and "in-law" relationships of gay and lesbian adults. Perceived ambivalence is revealed through gay and lesbian adults' characterizations of family members' simultaneous positive and negative overt and covert beliefs and behavior. In addition, the author refines the concept of collective ambivalence, wherein perceived ambivalence typifies an entire family unit. The findings further revealed the importance of broader sociological factors, such as homophobia, in structuring perceived ambivalence.
In-Situ Requirements Monitoring of Embedded Systems

We present a requirements-driven methodology enabling efficient runtime monitoring of embedded systems. The proposed approach extracts a runtime monitoring graph from system requirements specified using unified modeling language sequence diagrams with timing annotations. Nonintrusive, in-situ , on-chip hardware dynamically monitors the system execution, matches the specified requirements, and provides detailed information that can be analyzed in the event of a system failure. We present a case study using an autonomous vehicle subsystem demonstrating that the approach can achieve 100% detection rate of common failure types, including timing, dependency, synchronization, and sensor failures. We further analyze the relationship between coverage of system events, detection rates, and hardware requirements.
“Perfectly Compatible Objects”: Mr. Pitt Contemplates Britain And South America

“What may be the consequence to Spain of an hostile armament appearing off Mexico and Peru time only can discover; but there is every reason to suppose, from the present insurgent state of these Spanish settlements, that it would require but little address in a British Commander to excite a revolt” (“What” 3). The Times’ risky speculation in May 1790 adumbrates the beginning of British involvement with the “insurgent Spanish settlements” in the Romantic period. Earlier that year, Francisco de Miranda, known as “el Precursor” because he promoted the independence of Latin America long before Simon Bolivar appeared on the scene, had proposed to William Pitt that “England would assist [South America] to shake off the infamous oppression in which Spain keeps her” (“Proposal” 15: 111), and in exchange, England would obtain “the commercial intercourse to be formed between the English and natives upon the Grand Coasts of South America” (“Note” 15: 128). Miranda offered the vista of new markets in exchange for military assistance, no small incentive given the shift underway in the Atlantic economic system in the closing decades of the eighteenth century.1 Adam Smith, whom Miranda read, called attention to South America’s potential in The Wealth of Nations.
ASSESSING THE BENEFITS THAT COMMUNITY PHARMACIES CAN HAVE ON CHILDHOOD ASTHMA OUTCOMES.

Introduction The local Clinical Commissioning Group has funded an innovative one-year pilot project to assess the value of providing specialist paediatric pharmacist and physiotherapist support direct to families and health care professionals (GP9s, community pharmacists, practice nurses etc.) regarding asthma in the primary care setting. Community pharmacies are the one service that asthmatic children come in contact with in order to pick up their medications it was decided to encourage staff to provide interventions at the point of collection. Methods 22 large chain, small chain and independent community pharmacy branches were included in the pilot (out of 152 within CCG area) with a total of 31 pharmacists and 67 assistants trained to provide the service. The plan was to provide ‘back to basics’ leaflets on collection of prescription to help improve education on the medications being used; provide inhaler technique counselling on the collection of all prescriptions for children; encourage pharmacist9s to perform medicines use reviews and the new medicines service in asthmatic children of high school age (for which they could collect the standard NHS fee). In order to assess the benefits of this, the pharmacist or assistant would first perform the standard asthma control test, marked out of 25 with the parent/patient completing an online version one month later to assess any improvement in symptom management. In order to trace the number of MURs, NMS, inhaler counselling sessions and leaflets given out a tally chart was completed each month by the branches involved. Results Unfortunately of the 22 branches that signed up to the pilot only 15 returned tally charts to the team. Over a six month period 23 MUR9s, 3 NMS and 32 inhaler technique sessions were performed with 67 leaflets distributed. Of a possible 55 asthma control tests (MURs and inhaler technique counselling sessions) only 23 patients completed the four week post intervention online form. Of those completed the average asthma control test score increased by 7 points (30% increase). In particular feedback from the pharmacists involved was that the inhaler counselling sessions were of particular benefit to parents/patients. Feedback from the pharmacy teams in general was positive with many stating it was good to be more involved in the care of children9s conditions; however many stated in order for the service to roll out to a wider audience the scheme would have to provide a financial incentive for the large chains to take part. Conclusions It is clear that interventions performed by the community pharmacy teams can help improve symptom control in asthmatic children. In particular ensuring patients are using their medications correctly appears to be key to symptom control. Encouraging pharmacists to provide child friendly MURs should be investigated further to prove the benefit of this service further. It should be noted that ensuring patients are using their medications correctly is already part of the essential service contract for pharmacies.
Position: Some thoughts on the future of parallel computing and connectionist massively parallel models

We discuss the future of massively parallel computing from a fundamental architecture standpoint. Our central thesis is that various versions of Moore's Laws will all unavoidably break down over the next two to three decades, due to fundamental limitations imposed by the laws of physics (especially quantum mechanics). Therefore, the end to scaling-up von Neumann-based architectures by adding more cores and other incremental technology advancements is within sight. How are these challenges to be overcome, in order to continue making computation faster, cheaper, more energy efficient and more reliable? One possible answer lies in connectionist massively parallel models, based on (artificial) neural networks and other paradigms from biology, neuroscience and statistical physics. We discuss what would such massively parallel connectionist computers be like if they were to be based on “implementing neural networks in the hardware”, and undertake several thought experiments comparing and contrasting the hypothetical connectionist parallel machines with the “classical” multicore supercomputers and large-scale distributed computing systems.
Consensus and multiplex approach for community detection in attributed networks

An attributed network has nodes with attribute vectors. For community detection on an attributed network, we exploit the attributes to disentangle the potentially mixed topological structures. We describe a multiplex representation scheme for overlapping community detection in attributed networks and find consensus communities across layers of different connection structures. We test the method on Twitter, Facebook and Google+ networks and the results are comparable to state of the art. We show that the use of attribute vectors improves detection accuracy. Experiments on synthesized networks show that this method improves the detectability of communities.
Amplitude Equation Models for the Interaction of Shocks with Nonlinear Dispersive Wave Envelopes

Mode coupling between hyperbolic and dispersive waves is discussed in a general context. A class of amplitude equations is then introduced and used to study the interaction of a shock wave with a dispersive wave envelope. In particular, we describe and analyze a system similar in structure to the well-known Zakharov equations from weak plasma turbulence theory, but with a nonlinear conservation equation that allows for finite time shock formation. Special attention is focused on the incompressible limit in which the shock speed is large compared to the underlying group velocity of the dispersive wave. This limit is also an integrable limit in which the model reduces to the nonlinear Schrodinger equation. In this limit, we study the interaction of a ‘fast’ shock wave and a single hump soliton. First we analyze the weakly coupled problem in which the shock evolves independently of the dispersive wave. We show that the shock formation rives a finite time blow-up in the generalized frequency, —θ t , of the dispersive wave. We then analyze the fully coupled problem and develop a multi-scale, near-integrable asymptotic method to derive the effective leading order shock equations and the leading order modulation equations governing the phase and amplitude of the dispersive wave envelope. A sequence of numerical experiments is then performed on the leading order shock equation to depict some of the interesting interactions predicted by the analysis.
It’s Past Time for Practical Computer Checked Proofs of Program Correctness

In 1961 I published my first paper on computer-checked proofs of program correctness. In it I proposed that soon buyers would not pay for programs until furnished with computer checked proofs that they met there specifications. I was careful to point out that the buyer would have to be careful that the specification reflected his real requirements. Alas, almost 30 years later computer checked proofs are still not in practical use.
Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood.

Abstract The neuropeptide oxytocin (OT) has been implicated in a wide range of affiliative processes. OT exerts its functions via OT receptors, which are encoded by the oxytocin receptor gene (OXTR). Epigenetic modification of OXTR through the process of DNA methylation has been associated with individual differences in behavioral phenotypes. Specifically, lower levels of OXTR methylation have been linked to better social and affective functioning. However, research on epigenetic mechanisms of OXTR is scarce in non-clinical populations, and even less is known about epigenetic variability across adulthood. The present study assessed methylation levels at OXTR CpG site −934 and plasma OT levels in 22 young (20–31 years, M = 23.6) and 34 older (63–80 years, M = 71.4) participants. Lower levels of OXTR methylation and higher plasma OT levels were associated with less self-reported attachment anxiety in young but not older participants, with largely independent contributions of OXTR methylation and plasma OT levels. In contrast, in the overall sample, lower levels of OXTR methylation were associated with higher self-reported attachment avoidance. Age analysis suggested that these results were largely driven by young adults. Plasma OT levels were unrelated to attachment avoidance. Taken together, these findings support the emerging notion in the literature that epigenetic properties of OXTR, in addition to endogenous OT levels, are related to adult attachment. Further, the age effects observed in the associations between OXTR methylation, plasma OT, and adult attachment emphasize the importance of adopting a developmental perspective when studying properties of the OT system and their relation to affiliative processes. Findings contribute to growing evidence suggesting that epigenetic modification of genes regulating OT pathways and endogenous OT levels are associated with the way people form and maintain intimate social relationships.
Mechanism of Kelvin and Rossby waves during ENSO events

¶The fields of sea-level height anomaly (SLHA) and surface zonal wind anomaly (SZWA) have been analyzed to investigate the typical evolution of spatial patterns during El Nino-Southern Oscillation (ENSO) events. Sea surface temperature (SST) changes during ENSO events are represented as an irregular interplay of two dominant modes, low-frequency mode and biennial mode. Cyclostationary principal component (PC) time series of the former variables are regressed onto the PC time series of the two dominant SSTA modes to find the spatial patterns of SLHA and SZWA consistent with the two SSTA modes. The two regressed patterns of SLHA explain a large portion of SLHA total variability. The reconstruction of SLHA using only the two components reasonably depicts major ENSO events. Although the low-frequency component of SST variability is much larger than the biennial component, the former does not induce strong Kelvin and Rossby waves. The biennial mode induces much stronger dynamical ocean response than the low-frequency mode. Further decomposition of the SLHA modes into Kelvin and Rossby components shows how these two types of equatorial waves evolve during typical ENSO events. The propagation and reflection of these waves are clearly portrayed in the regressed patterns leading to a better understanding of the wave mechanism in the tropical Pacific associated with ENSO. A close examination suggests that the delayed action oscillator hypothesis is generally consistent with the analysis results reported here. Rossby wave development in the central Pacific in the initiation stage of ENSO and the subsequent reflection of Kelvin waves at the western boundary seems to be an important mechanism for further development of ENSO. The development of Kelvin waves forced by the surface wind in the far-western Pacific cannot be ruled out as a possible mechanism for the growth of ENSO. While Kelvin waves in the far-western Pacific serve as an intiation mechanism of ENSO, they also cause the termination of existing ENSO condition in the central and eastern Pacific, thereby leading to a biennial oscillation over the tropical Pacific. The Kelvin waves from the western Pacific erode the thermocline structure in the central Pacific preventing further devlopment of ENSO and ultimately terminating it. It should be emphasized that this wave mechanism is clear and active only in the biennial mode.
CO Imaging in piloted liquid-spray flames using femtosecond two-photon LIF

Abstract Liquid-spray flames are encountered in many practical combustion devices such as gasoline direct injection and diesel engines, gas turbine combustors as well as industrial furnaces. As opposed to gaseous fuels, additional phase-change steps present in liquid sprays not only complicate the overall combustion process, but also make in-situ, laser-based combustion diagnostics challenging. In particular, the formation of carbon monoxide (CO) due to incomplete fuel-air mixing and partial oxidation becomes a major challenge. In this study, we apply femtosecond, two-photon laser-induced fluorescence (fs-TPLIF) to measure CO concentration in piloted liquid-spray flames, taking into account possible signal interferences in the 230.1-nm, B1Σ+←X1Σ+ excitation scheme. A modified, flat-flame McKenna burner fitted with a direct-injection high-efficiency nebulizer (DIHEN) was used to produce piloted liquid-methanol spray flames. Although single-laser-shot OH-PLIF images show the presence of strong turbulent interactions in the core region, shot-averaged OH-PLIF images indicate that near the nozzle-exit region, the primary reaction takes place in an annular region around the droplet cloud, in general. A detailed spectroscopic study reveals that the signal interference at 460 nm originating from the second-order scattering of the excitation laser, which becomes approximately an order of magnitude stronger than CO fluorescence spectral lines near the nozzle exit region. The specific spectral filtering scheme introduced in our recent work is proved to be capable of suppressing interferences primarily originating from C2 Swan-band emissions. Two-dimensional CO maps along with OH-PLIF flame structure data provide key insights into the CO formation in piloted liquid-spray flames, while providing critical validation datasets for advanced computational models.
Choreography as Design.

Design-based learning is often promoted as a way for students to practice the skills essential for their future success; however, little research in this area has been conducted in the field of dan...
Potential Role of Nitrobiolome in Autoimmune Disease: Efficacy of GSNO in EAE.

S-nitrosoglutathione (GSNO) is a physiological nitric oxide (NO) carrier molecule important in modulation of NO-signaling. Cellular GSNO homeostasis is maintained by its synthesis by nitric oxide synthase (NOS) as well as its catabolism by GSNO reductase (GSNOR). Treatment of EAE mice (wild-type /WT) with exogenous GSNO or GSNOR inhibitor (N6022) significantly alleviated the clinical disease and associated myelin damage. In addition, more profound alleviation of EAE disease was observed in mice deficient in GSNOR (GSNOR −/− ). However, EAE disease was further exacerbated in mice deficient in inducible NOS (iNOS −/− ) as compared to WT mice. As expected, the spleen levels of S-nitrosothiol proteins were higher in GSNOR −/− EAE mice but lower in iNOS −/− EAE mice compared to WT EAE mice indicating a negative correlation of spleen GSNO levels with EAE disease severities. Both GSNO and N6022 treated EAE mice had decreased T H 17 and increased CD4 + /CD25 + /FOXP3 − Treg differentiations without any significant alterations in other CD4 + T cell subset differentiation. Accordingly, CD4 T+ cells from GSNO or N6022 treated EAE mice produced lower amount of IL-17 and higher amount of IL-10 compared to the cells from untreated WT EAE mice. GSNOR −/− EAE mice also exhibited decreased T 17 and increased CD4 + /CD25 + /FOXP3 − Treg differentiations. On the other hand, iNOS −/− EAE mice exhibited increased T H 17, but decreased Tregs differentiations compared to WT EAE mice. In summary, these studies document that nitrobiolome (GSNO) participates in differentiation of autoreactive T H 17 and Treg subsets during the course of EAE, and that GSNO as a potential therapeutic drug for multiple sclerosis. Supported in-part by VA(BX002829) and NIH(NS037766).
Supervisory Orientations and Salesperson Work Outcomes: The Moderating Effect of Salesperson Location

Although a growing number of companies have salespeople stationed at a site other than their supervisors' (i.e., are remotely located), relatively little attention has been paid in the literature to the differences between managing co-and remote located salespeople. Accordingly, we test the moderating effect of salesperson location on the relationships between three supervisory orientations—output, activity, and capability—and salesperson satisfaction with supervisor and performance.The results show that salesperson location moderates the relationship between supervisory activity orientation and satisfaction such that activity orientation has a positive effect on the satisfaction of remote located salespeople, but a negative effect on the satisfaction of co-located salespeople. We find that end-results orientation is positively related to the satisfaction of co-located salespeople but not of remote located salespeople. Finally, supervisory capability orientation is positively linked to the performance of ...
Leveraging the zebrafish to model organ transplantation.

Purpose of review The availability of organs for transplant fails to meet the demand and this shortage is growing worse every year. As the cost of not getting a suitable donor organ can mean death for patients, new tools and approaches that allows us to make advances in transplantation faster and provide a different vantage point are required. To address this need, we introduce the concept of using the zebrafish (Danio rerio) as a new model system in organ transplantation. The zebrafish community offers decades of research experience in disease modeling and a rich toolbox of approaches for interrogating complex pathological states. We provide examples of how already existing zebrafish assays/tools from cancer, regenerative medicine, immunology, and others, could be leveraged to fuel new discoveries in pursuit of solving the organ shortage. Recent findings Important innovations have enabled several types of transplants to be successfully performed in zebrafish, including stem cells, tumors, parenchymal cells, and even a partial heart transplant. These innovations have been performed against a backdrop of an expansive and impressive list of tools designed to uncover the biology of complex systems that include a wide array of fluorescent transgenic fish that label specific cell types and mutant lines that are transparent, immune-deficient. Allogeneic transplants can also be accomplished using immune suppressed and syngeneic fish. Each of these innovations within the zebrafish community would provide several helpful tools that could be applied to transplant research. Summary We highlight some examples of existing tools and assays developed in the zebrafish community that could be leveraged to overcome barriers in organ transplantation, including ischemia-reperfusion, short preservation durations, regeneration of marginal grafts, and acute and chronic rejection.
Quill and Cross in the Borderlands: Sor María de Ágreda and the Lady in Blue, 1628 to the present: by Anna M. Nogar. Notre Dame: University of Notre Dame Press, 2018, 457 pp. (ISBN 9780268102135)

Quill and Cross in the Borderlands is a sociocultural reexamination of the ‘Lady in Blue’ narrative of 17th-century mystic Sor Maria de Jesus de Agreda’s evangelization of the New Mexican Jumano tr...
Core SSW Services Working Paper: Referral, Screening, Assessment, & Service Delivery Process (RSASD) for School Social Workers

The framework offered here is rooted in a variety of sources, primary among them my own research on SSW practice, consultation with the PLC Project Advisory Board, and the ongoing work with the various PLCs here in Ontario. I am grateful for all the different PLC members, co-leads, and outside research and practice experts that helped form this draft framework. Ontario SSW Managers and the 70+ Professional Learning Community (PLC) members identified significant concerns with how SSW struggled to manage the different expectations of their “host setting.” A primary concern was the lack of control many SSW reported having with how their caseload came about, specifically in how referrals were made for SSW services. This Plain Language Summary (PLS) will detail the key components of the proposed new Referral, Screening, Assessment, and Service Delivery process (RSASD). Drawing on the work of Dr. Kelly the leadership of the Assessment/Criteria PLC, we will identify the best evidence-informed practices (EIP) in screening and assessing student clinical concerns, and suggest some best practices that formed the basis for our new RSASD model. The EIP in each PLS will also be aligned where applicable with the evidence-based practice (EBP) Common Elements identified by School Mental Health-Assist (SMH-ASSIST). Additional recommendations for further reading and implementation strategies are included in the PLS, while a more extensive annotated bibliography and related materials are included elsewhere as part of all of the Ontario SSW PLC ToolKits.
Ecological Disasters and Mental Health: Causes, Consequences, and Interventions

Ecological disasters highlight the importance of understanding natural disasters as they relate to a changing global climate. Such disasters often have a predictable pattern of evolving over time and anticipated psychological and behavioral problems and community disruptions. Various factors enhance transmission of these adverse effects beyond the geographic location of the ecological disaster, with certain populations being particularly vulnerable to these effects. Understanding the range and pattern of these effects can aid in optimizing interventions. The use of evidence-informed interventions can reduce distress, enhance well-being, and improve functioning for affected individuals and communities. Effective preparedness involves an understanding of these factors, incorporation of them at all stages of disaster management, and continuous education and training for disaster planners and responders.
Local asymptotics for orthonormal polynomials on the unit circle via universality

Let µ be a positive measure on the unit circle that is regular in the sense of Stahl, Totik, and Ullmann. Assume that in some subarc J, µ is absolutely continuous, while µ′ is positive and continuous. Let {φn} be the orthonormal polynomials for µ. We show that for appropriate ζn ∈ J, $${{\rm{\{ }}{{{\varphi _n}({\zeta _n}(1 + {\textstyle{z \over n}}))} \over {{\varphi _n}({\zeta _n})}}{\rm{\}}}_{n \ge 1}}$$ is a normal family in compact subsets of ℂ. Using universality limits, we show that limits of subsequences have the form ez + C(ez − 1) for some constant C. Under additional conditions, we can set C = 0.
Multi-Radiologist User Study for Artificial Intelligence-Guided Grading of COVID-19 Lung Disease Severity on Chest Radiographs.

Rationale and Objectives Radiographic findings of COVID-19 pneumonia can be used for patient risk stratification; however, radiologist reporting of disease severity is inconsistent on chest radiographs (CXRs). We aimed to see if an artificial intelligence (AI) system could help improve radiologist interrater agreement. Materials and Methods We performed a retrospective multi-radiologist user study to evaluate the impact of an AI system, the PXS score model, on the grading of categorical COVID-19 lung disease severity on 154 chest radiographs into four ordinal grades (normal/minimal, mild, moderate, and severe). Four radiologists (two thoracic and two emergency radiologists) independently interpreted 154 CXRs from 154 unique patients with COVID-19 hospitalized at a large academic center, before and after using the AI system (median washout time interval was 16 days). Three different thoracic radiologists assessed the same 154 CXRs using an updated version of the AI system trained on more imaging data. Radiologist interrater agreement was evaluated using Cohen and Fleiss kappa where appropriate. The lung disease severity categories were associated with clinical outcomes using a previously published outcomes dataset using Fisher's exact test and Chi-square test for trend. Results Use of the AI system improved radiologist interrater agreement (Fleiss κ = 0.40 to 0.66, before and after use of the system). The Fleiss κ for three radiologists using the updated AI system was 0.74. Severity categories were significantly associated with subsequent intubation or death within 3 days. Conclusion An AI system used at the time of CXR study interpretation can improve the interrater agreement of radiologists.
Climate Adaptation Strategies: How do we 'Manage' Managed Retreat?

During my twenty years in the U.S. military, any mention of the word “retreat” would initially be met with furrowed brows, heavy sighs, and consternation. After all, retreat conjures negative images of defeat and loss to the enemy. Similarly, climate change is an overpowering “enemy” force that threatens coastal communities. Climate change will increasingly require both homeowners and policymakers to accept the sobering reality that we must move away from our most vulnerable communities. This will require difficult, heart-wrenching, climate adaptation decisions. Retreat is an emotionally fraught choice, but often the best option. By one estimate, building sea walls for coastal communities will cost U.S. taxpayers in excess of $400 billion—we simply cannot “accommodate our way” out of climate change. But rather than seeing retreat as a failure, we must re-conceptualize climate change—driven managed retreat for what it presents: a sensible, albeit difficult option that offers fresh opportunities. It represents a mature evolution and acknowledgement of climate change’s true costs, risks, and threats (Siders 2019). But how do we “manage” managed retreat? And what are the legal barriers in doing so?
LibGuides Gone Viral: A Giant LibGuides Project during Remote Working

Librarian-created course guides were created at The Ohio State University using the LibGuides system, with 460 courses being connected to undergraduate courses in six departments. The process of id...
Snaking bifurcations of localized patterns on ring lattices

We study the structure of stationary patterns in bistable lattice dynamical systems posed on rings with a symmetric coupling structure in the regime of small coupling strength. We show that sparse coupling (for instance, nearest-neighbour or next-nearest-neighbour coupling) and all-to-all coupling lead to significantly different solution branches. In particular, sparse coupling leads to snaking branches with many saddle-node bifurcations, whilst all-to-all coupling leads to branches with six saddle nodes, regardless of the size of the number of nodes in the graph.
Thermal Metasurfaces: Complete Emission Control by Combining Local and Nonlocal Light-Matter Interactions

Theorists have shown that carefully patterned surfaces can transform the emission from a hot object into a polarized, focused light beam.
A Different Type of "Against Medical Advice": When Patients Refuse Discharge.

Patients are often eager to get out of the hospital; so eager that some decide to leave before their treatment team feels it is medically appropriate for them to do so. This is known as an AMA disc...
Case Report Of Malignant Hypertension With Thrombotic Microangiopathy Masquerading As Thrombotic Thrombocytopenic Purpura With Neurological Features: (2823)

Objective: NA Background: A 21 year-old gentleman presented with complete visual loss in left eye for few minutes followed by persistent blurriness. He reported two months of headaches, two weeks of hematuria and transient left arm numbness for couple of minutes, a week before presentation. Past history significant for hypertension while in middle school. On arrival blood-pressure was 280/165. Examination noted flame-shaped retinal hemorrhages and grade 2 papilledema on the left eye in addition to mild petechial rash on bilateral shins. Reminder of the examination was unremarkable. Labs significant for platelet count 115,000/microliter(Normal:150,000–450,000/microliter), Lactate Dehydrogenase 547 Units/Liter(Normal:120–220 Units/Liter), haptoglobin 8 mg/dl(Normal: 14–258 mg/dl) and multiple schistocytes on peripheral smear. Urinalysis showed packed Red Blood Cells with proteinuria. Other relevant labs were unremarkable. MR Brain noted T2 FLAIR hyperintensities in bifrontal, brainstem associated with punctate area of diffusion restriction plus susceptibility weighted artifact in the right putamen. Based on MR brain, Posterior Reversible Encephalopathy Syndrome(PRES) was suspected with or without possible contribution from hypertension. Design/Methods: On arrival anti-hypertensives were initiated resulting in immediate resolution of headaches. Plasma exchange was initiated on the second day with presumption of Thrombotic Thrombocytopenic Purpura(TTP) but absence of fever, modest thrombocytopenia prompted consideration of Malignant Hypertension(MH). Plasma exchange was stopped and ADAMTS-13 activity was later found normal. Patient was discharged on oral anti-hypertensives. Results: At one month follow up, he had no complaints except some left eye blurriness. Repeat MR Brain at one month noted resolution of the T2 FLAIR hyperintensities. Conclusions: Thrombotic microangiopathy leading to hemolytic anemia, thrombocytopenia, and organ injury is well recognized in MH. MH is well-known mimicker of TTP. We would like to highlight that PRES and flame-shaped retinal hemorrhages can be seen in both the conditions and does not necessarily help to differentiate. Modest thrombocytopenia, history of hypertension, significant hypertension on presentation can be clues towards MH.
Using lexical context to discover the noun category: Younger children have it easier

Abstract Prior work has demonstrated that distributional dependencies between word or morpheme-like entities in artificial and naturalistic language can detect clusters of words which broadly conform to the categories of the adult language ( Brent & Siskind, 2001 ; Mintz, 2002 ; Redington & Chater, 1998 ). In this work, we examine the hypothesis that the distributional statistics useful for the discovery of the noun category are more useful in speech to younger children compared to older children (approximately 1–3 vs 3–6 years of age). First, using a novel method for quantifying the extent that nouns occur in mutually shared contexts, we demonstrate an advantage for speech to younger compared to older children. Second, we develop a theoretical framework for understanding why caregiver speech might be scaffolded in this way, and test its predictions against information theoretic patterns computed on child-directed speech. Our account, based on entropy maximization, and anchoring originally proposed by Cameron-Faulkner, Lieven, and Tomasello (2003) , clarifies issues in incremental learning from nonstationary input—the problem faced by language learners—and paves the way toward integrating the scaffolded organization of children's early language environment into computational models of acquisition.
The Assembly of Mitochondria

Mitochondria are involved in their own assembly. Although a good deal is now known about this topic, many of the details are still unclear and in the process of being elucidated.
Semidirect sum of groups in which endomorphisms are generated by inner automorphisms

An I-E group is a group G in which every endomorphism is finitely generated by its inner automorphisms. In this paper a characterization for a semidirect sum of I-E groups to be an I-E group is obtained and some wellknown results are generalized. We then use this characterization to prove that a semidirect sum of finite I-E groups will again be an I-E group if the normal semidirect summand is unique and fully invariant. Conditions for a group to be an I-E group are also given.
Awareness, treatment, and control of hypertension and hypercholesterolemia among insured residents of New York City, 2004.

INTRODUCTION Health care access and sociodemographic characteristics may influence chronic disease management even among adults who have health insurance. The objective of this study was to examine awareness, treatment, and control of hypertension and hypercholesterolemia, by health care access and sociodemographic characteristics, among insured adults in New York City. METHODS Using data from the 2004 New York City Health and Nutrition Examination Survey, we investigated inequalities in the diagnosis and management of hypertension and hypercholesterolemia among insured adults aged 20 to 64 years (n = 1,334). We assessed differences in insurance type (public, private) and routine place of care (yes, no), by sociodemographic characteristics. RESULTS One in 10 participants with hypertension and 3 in 10 with hypercholesterolemia were unaware and untreated. Having a routine place of care was associated with treatment and control of hypertension and with awareness, treatment, and control of hypercholesterolemia, after adjusting for insurance type, age, sex, race/ethnicity, foreign birth, income, and education. Differences in systolic blood pressure and total cholesterol between people with versus without a routine place of care were 2 to 3 times the difference found between people with public versus private insurance. Few differences were associated with sociodemographic characteristics after adjusting for routine place of care and insurance type; however, male sex, younger age, Asian race, and foreign birth with short-term US residence reduced the odds of having a routine place of care. Neither income nor education predicted having a routine place of care. CONCLUSION Sociodemographic characteristics may influence chronic disease management among the insured through health care access factors such as having a routine place of care.
The effect of active and passive third body film in friction of carbons Part 1: Friction and wear performance at various scales

In the friction of carbon materials, it has been found that the coefficient of friction is dependent on the total energy absorbed by a given mass and the rate at which the energy is dissipated. Usually, low energy absorption and low rate of energy dissipation produces relatively high coefficients of friction. Conversely, high energy absorption and high rate of energy dissipation leads to lower coefficients of friction. In addition, testing at low energy input in a moist environment produces a low coefficient of friction, which may increase significantly during the course of the test. Similar friction transitions occur during high energy tests. However, these do not appear related to moisture effects. In some higher velocity tests, very high local temperatures were detected even though the bulk temperature rise is relatively low. The scope of this paper focuses on the transient changes of friction coefficient and the hot spotting phenomena. The tests were conducted using both pin-on-disk and disk-on-disk setups. Although test scales were different in both tests, a very good match in results was found.