cssi/SciSciGPT-SciSciNet huggingface dataset:
Allelic loss on chromosome 22q in epithelioid sarcomas.

Epithelioid sarcomas are soft tissue tumors with an indolent, but potentially aggressive, clinical behavior. Distinction from other benign and malignant entities may be a diagnostic dilemma. In this study, we evaluate the presence of loss of heterozygosity (LOH) of chromosome 22q in tumor DNA from 13 epithelioid sarcomas, four epithelioid angiosarcomas, and two epithelioid hemangioendotheliomas, and investigate its possible role in diagnosis. LOH was detected in 6 of 10 (60%) of the informative epithelioid sarcomas. No allele loss was detected in the informative vascular tumors, three angiosarcomas, and two hemangioendotheliomas. Chromosome 22q carries the locus of a tumor suppressor gene, the neurofibromatosis 2 (NF2) gene, which has been shown to be lost or mutated in some NF2-related tumors, sporadic meningiomas, and vestibular schwannomas, as well as a few other tumors. Our data suggest that a region of chromosome 22q may be the locus of a tumor suppressor gene involved in the tumorigenesis of these neoplasms. Genetic alterations of yetunknown tumor suppressor genes in this region, or even the NF2 tumor suppressor gene, may play a role in epithelioid sarcomas tumorigenesis. The fact that LOH was only detected in epithelioid sarcomas and not in the vascular tumors studied suggests a possible role for this marker in diagnosis. Hum Pathol 29:604–608. This is a US government work. There are no restrictions on its use.
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII

The complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII reveals that it contains 269 predicted or known genes (300 base pairs or larger). Fifty-nine of these genes (22 percent) were previously identified. Of the 210 novel genes, 65 are predicted to encode proteins that are similar to other proteins of known or predicted function. Sixteen genes appear to be relatively recently duplicated. On average, there is one gene approximately every 2 kilobases. Although the coding density and base composition across the chromosome are not uniform, no regular pattern of variation is apparent.
Electron shuttling across the interface of CdSe nanoparticles monitored by femtosecond laser spectroscopy

The formation and decay of the optical hole (bleach) for 4 nm CdSe nanoparticles (NPs) with adsorbed electron acceptors (1,4-benzoquinone and 1,2-naphthoquinone) and the rise and decay of the reduced electron acceptors formed after interfacial electron transfer from the CdSe NPs were investigated by femtosecond laser spectroscopy. The ultrashort (200−400 fs) rise times of the bleach at the band-gap energy of the CdSe NP as well as of the acceptor radical anion are found to increase with increasing the excitation energy. This suggests that the electron transfer from the CdSe NP to the quinone electron acceptor occurs after thermalization of the excited hot electrons. The decay times of the transient absorption for the electron acceptor radical anions are found to be comparable to that of the CdSe NP bleach recovery time (3 ps). This suggests that the surface quinones shuttle the electron from the conduction band to the valence band of the excited NP. We contrast this behavior with the excited-state dynamic...
Blood vitamin B12 status of the dairy cow in late pregnancy and early lactation.

Abstract The vitamin B 12 content of the blood of Holstein cows was determined before parturition and at intervals during early lactation to test the hypothesis that a partial depletion of reserves might occur at this time. Blood vitamin B 12 levels were found to vary significantly (P 12 levels and milk production, grain consumption, or blood glucose levels during early lactation.
Update in Palliative Care - 2011

INTRODUCTION The aim of this update is to summarize scientifically rigorous articles published in 2010 that serve to advance the field of palliative medicine and have an impact on clinical practice.
Synthesis of Polystyrene-block-Poly(methyl methacrylate) with Fluorene at the Junction: Sequential Anionic and Controlled Radical Polymerization from a Single Carbon

Polystyrene-block-poly(methyl methacrylate) (PS-b-PMMA) has been synthesized by sequential anionic and reverse atom transfer radical polymerization (ATRP) or a variation of nitroxide mediated polymerization (NMP) from a single initiating site, specifically the 9-carbon on 2,7-dibromofluorene or fluorene. The addition of the second arm (PS) relied on thermal decomposition of 2,2'-azoisobutyronitrile (AIBN) to generate radicals, abstracting the 9-H on the polymer-bound fluorene species to form the initiating radical. Styrene was not present in the reaction mixture when AIBN was decomposed, preventing competition between addition across the monomeric alkene and hydrogen abstraction from the fluorene. After 1 h, styrene was introduced and mediation of the subsequent radical polymerization was achieved by the presence of CuCl 2 /ligand or TEMPO. Characterization of the diblock copolymers by gel permeation chromatography (GPC) revealed substantial shifts in number average molecular weight (M n ) values compared to the anionically prepared PMMA macroinitiator, while polydispersity indices (PDI's) remained relatively low (typically < 1.5). Characterization by UV detection with GPC (at 310nm) verified that the diblock polymer is chromophore-bound, which was further verified by UV-vis spectroscopy of the isolated diblock.
Oscillating stress on viscoelastic behavior of thermoplastic polymers

Polymers are used in many applications where they are subjected to cyclic stresses. PVC and HDPE piping are often used in systems that include rotating machinery that cause mechanical vibration. Recent testing of thermoplastics indicates that there may he a large effect on the viscoelastic strains of thermoplastics from oscillating stresses. Cyclic loading on the permanent set of cross-linked elastomers has been studied. Perhaps, as expected, the effect of the oscillating behavior is measurable. Two types of tests have been conducted. First, tensile tests on HDPE standard specimens were conducted where oscillating stresses were superimposed onto an initial static or mean stress. These measurements showed a rapid decrease in the oscillating stresses when compared to measurements when steady nonoscillating stresses are applied to the same type of specimen. In the second test series, pressurized HDPE piping was subject to oscillating bending stresses. Ratcheting of the hoop strains in the pipe occurs. Results show that these strains follow the constitutive relationships of linear viscoelasticity and experimental results imply that viscoelastic changes are accelerated by stress oscillations. These preliminary results seem to indicate that the effects of oscillating stresses on the viscoelastic behavior of thermoplastics may be significant. A systematic study is required to further understand this behavior.
The role of the community mental health center in prevention of infant, child and adolescent disorders: retrospect and prospect.

The Congressional Joint Commission on Mental Health of Children 1965–67 gathered and published a great deal of data on Prevention and Early Intervention that was subsequently ignored by Congress and the Administration. Community Mental Health Centers, since their beginnings in the mid 60's, have not been able to concern themselves with prevention because of the overwhelming demands for treatment of a very psychiatrically disturbed adult population. The closing of State Hospitals without provision for community resources to care for these severely disturbed individuals, for economic and political reasons, unfairly burdened community mental health centers. In the intervening years, a great deal more has been learned about primary, secondary, and tertiary prevention for infants, children and adolescents. This paper describes some of the new knowledge and indicates how much of our current knowledge could be used by Community Mental Health Centers to take advantage of the new funding available in many prevention areas. A few early intervention and prevention projects are described.
Antiviral drugs in Jakob-Creutzfeldt disease.

: A 61-year-old patient had a rapidly progressive neurological syndrome consisting of aphasia, dysgraphia, dyslexia, right-left disorientation, slight motor lateralizing signs, tremor and myoclonic jerks. The electroencephalogram showed the bursts of spikes and slow waves (1 per second) characteristic of Jakob-Creutzfeldt disease (spastic pseudosclerosis). A Nevin-Jones variant of the disease was diagnosed. Amantadine and idoxuridine were given without any positive effect. The patient died in a state of septicemia. A review of experience with antiviral drugs in slow virus neurological infections is presented.
Venus - Chemical weathering of igneous rocks and buffering of atmospheric composition

Data from the Pioneer Venus radar mapper, combined with measurements of wind velocity and atmospheric composition, suggest that surface erosion on Venus varies with altitude. Calcium- and magnesium-rich weathering products are produced at high altitudes by gas-solid reactions with igneous minerals, then removed into the hotter lowlands by surface winds. These fine-grained weathering products may then rereact with the lower atmosphere and buffer the composition of the observed gases carbon dioxide, water vapor, sulfur dioxide, and hydrogen fluoride in some regions of the surface. This process is a plausible mechanism for the establishment in the lowlands of a calcium-rich mineral assemblage, which had previously been found necessary for the buffering of these species.
Thermal Finite Difference Analysis of Threshold Heating for Nanoscale Machining

We are investigating a new manufacturing process utilizing T hreshold H eating and E mission from N anotubes (THEN) to remove clusters of atoms from workpiece surfaces. A pulsed laser will locally heat a workpiece to the threshold temperature, and then electrons emitted from nanotube tips will create nanoscale features within the heated zone. This paper concentrates on modeling the temperature distribution in the workpiece caused by radiation and conduction transfer. Our finite difference model considers a Gaussian laser beam radiating through a transparent substrate onto a metallic workpiece layer. The finite difference model will eventually be integrated with thermal models of electron emission and absorption to achieve a complete model of the THEN process.Copyright © 2002 by ASME
Heparin‐induced thrombocytopenia and recurrent thromboembolism in siblings

Two brothers with heparin-induced thrombocytopenia and multiple arterial and venous thromboembolism affecting peripheral vessels are described. Heparin-dependent antiplatelet antibody was detected using platelet aggregometry in both patients. Although these observations may be coincidental, the possibility of familial occurrence of this adverse reaction to heparin cannot be excluded with certainty.
Another Form of the Generalization of the KdV Equation into the Integro-Differential Equation

Using the integral operator introduced by Joseph to derive finite depth fluid equation, we derive one integrable nonlinear integro-differential equation. The present equation also reduces to the KdV equation in the limit as Joseph's finite depth fluid equation does. The explicit N -soliton solutions have been derived to the equation.
Assessing Attitudes about Genetic Testing as a Component of Continuing Medical Education

To investigate the attitudes among mental health professionals regarding the use of genetic testing. Psychiatrists and other mental health professionals (N=41) who were enrolled in a week-long course in psychiatric genomics completed questionnaires before and after the course designed to assess how diagnostic genetic tests should be used and the value of pharmacogenomic testing for clinical practice. Only 5% of the course participants knew their genotype for the CYP 2D6 and CYP 2C19 genes at the time they participated in the course. However, after completing the course, 95% of the participants who had not been tested responded that they would be tested if genotyping was provided at no cost. Most of the participants reported that adults have the right to know their genotypes. Specifically, a majority of participants also reported that adults should have access to information regarding their genetic predispositions to both Huntington’s disease and Alzheimer’s disease. A majority of participants believed that parents had the right to know the genotypes of their children and that adolescents should have access to their genotypes if they had parental permission or were emancipated minors. However, only 29% of participants reported that children ages 6 to 12 should have access to the results of their genotyping. Continuing medical educational programs can provide an effective and informative opportunity to develop a better understanding of contemporary perspectives of practicing clinicians. Despite some variability in beliefs regarding the implications of age and diagnosis for making genetic testing decisions, a majority of course participants reported that they would choose to be genotyped for two drug metabolizing enzyme genes. Furthermore, they felt that, in most circumstances, adults should be permitted to know their genotype.
Bowel perforation during retropubic sling procedure.

BACKGROUND:Bowel perforation is a rare complication of tension-free vaginal tape (TVT)–type sling procedures and has been reported in patients with a previous history of abdominal or pelvic surgery.CASE:A 77-year-old woman with no prior history of abdominal or pelvic surgery underwent elective surge
The destruction of liberty in French Guiana: law, identity and the meaning of legal space, 1794–1830

Abstract This article examines the colonial legal culture of French Guiana from 1794 to 1830 during a period marked by dramatic historical rupture; slaves in the colony who were liberated by decree of the French legislature in 1794 were returned to slavery under Napoleon. People who managed to remain free in the nineteenth century endured humiliating legal handicaps as well as challenges to their free status. In Guiana during this period, a person's access to the ‘rights of man and citizen’ depended on intricate and ultimately fragile legal structures. The perils besetting Guiana's freed people during and after the French Revolution often arose from the highly adjustable character of legal space – the legal status of imperial territory in relation to domestic soil. This article draws on archival materials including notarial documents and trial records to reconstruct the role of law and legal discourse in mediating everyday life, familial relationships and social encounters on the French colonial frontier.
Pure Red Cell Aplasia Associated With Hepatitis C Infection

Abstract We report the case of a 34-yearold woman with recurrent pure red cell aplasia and evidence of hepatitis Band C infection. Review of the English literature identified 19 prior cases in which pure red cell aplasia was associated with hepatitis. This case is the first in which serologic evidence of hepatitis C infection was documented. This patient also had porphyria cutanea tarda and marked hepatic siderosis but no active hepatitis or cirrhosis. Treatment with cyclophosphamide and prednisone produced complete remission of the pure red cell aplasia. Erythroid colony formation (colony-forming unit-erythroid and erythroid burst-forming unit) was reduced in cultures of bone marrow obtained during relapse but was normal in remission marrow. However, addition of the patient serum, whether collected during relapse or remission, inhibited erythroid colony formation by her bone marrow. These observations, and the known extrahepatic immunologic manifestations of hepatitis C infection, suggest that the pure red cell aplasia occurred because of an autoimmune mechanism provoked by the infection.
Testing the Chromosomal Speciation Hypothesis for Humans and Chimpanzees

Fixed differences of chromosomal rearrangements between isolated populations may promote speciation by preventing between-population gene flow upon secondary contact, either because hybrids suffer from lowered fitness or, more likely, because recombination is reduced in rearranged chromosomal regions. This chromosomal speciation hypothesis thus predicts more rapid genetic divergence on rearranged than on colinear chromosomes because the former are less porous to gene flow. A number of studies of fungi, plants, and animals, including limited genetic data of humans and chimpanzees, support the hypothesis. Here we reexamine the hypothesis for humans and chimpanzees with substantially more genomic data than were used previously. No difference is observed between rearranged and colinear chromosomes in the level of genomic DNA sequence divergence between species. The same is also true for protein sequences. When the gorilla is used as an outgroup, no acceleration in protein sequence evolution associated with chromosomal rearrangements is found. Furthermore, divergence in expression pattern between orthologous genes is not significantly different for rearranged and colinear chromosomes. These results, showing that chromosomal rearrangements did not affect the rate of genetic divergence between humans and chimpanzees, are expected if incipient species on the evolutionary lineages separating humans and chimpanzees did not hybridize.
Current status and new features of the Consensus Coding Sequence database

The Consensus Coding Sequence (CCDS) project (http://www.ncbi.nlm.nih.gov/CCDS/) is a collaborative effort to maintain a dataset of protein-coding regions that are identically annotated on the human and mouse reference genome assemblies by the National Center for Biotechnology Information (NCBI) and Ensembl genome annotation pipelines. Identical annotations that pass quality assurance tests are tracked with a stable identifier (CCDS ID). Members of the collaboration, who are from NCBI, the Wellcome Trust Sanger Institute and the University of California Santa Cruz, provide coordinated and continuous review of the dataset to ensure high-quality CCDS representations. We describe here the current status and recent growth in the CCDS dataset, as well as recent changes to the CCDS web and FTP sites. These changes include more explicit reporting about the NCBI and Ensembl annotation releases being compared, new search and display options, the addition of biologically descriptive information and our approach to representing genes for which support evidence is incomplete. We also present a summary of recent and future curation targets.
Mining data relationships for database damage assessment in a post information warfare scenario

After the detection of a cyber attack on a database system, the intrusion response team of any organization needs to know the damage profile immediately in order to design an appropriate response strategy. Unfortunately obtaining the precise damage status can take up to hours even days. This is because existing approaches to database damage assessment involve significant amount of work including scanning the log file or other auxiliary data structures. Our approach concentrates on making an estimated damage profile as soon as possible. This model is based exclusively on a priori knowledge of data relationships mined during normal database operation phase. This knowledge can be used during damage assessment phase for faster damage assessment.
Control of calcium release in functioning skeletal muscle fibers

This review focuses on the normal physiological mechanisms that control calcium release from the sarcoplasmic reticulum (SR) during electrical depolarization of functioning vertebrate skeletal muscle fibers. Special at­ tention is devoted to questions concerning the functional interactions between components of the calcium release and control system. In vertebrate skeletal muscle the two known components reside in separate but closely apposed membranes: the junctional membrane of the SR, which contains the SR calcium release channel, and the immediately adjacent membrane of the transverse tubules (TT) , which contains the TT membrane voltage-sensing elements that control the SR calcium channel. The TT system carries the electrical depolarization signal from the plasma membrane radially into the fiber for near-synchronous initiation of SR calcium release throughout the fiber volume. Several recent reviews have covered various functional aspects of these components as well as their interaction in physiological depolar­ ization-release coupling (6, 23, 35, 43, 65, 86, 108, 109, 110, l lI). The restricted length of the present review has required focus on selected areas to the unfortunate neglect of related but peripheral studies and use of only typical examples as references to general points. Molecular, structural, and molecular biological aspects of the calcium release and control system are presented in companion reviews (G Meissner; C Franzini-Armstrong & A Jorgensen, this volume).
How do features of sensory representations develop

Sensory representations in the brainstem and cortex have a number of features that support the idea that neural activity patterns are important in their development. Many of these features vary across species in ways that could result from perturbances in the balance of the effects of activity patterns and position-dependent gene expression. (1) Most notably, disruptions or septa in sensory maps often reflect actual discontinuities in the receptor sheet, and the discontinuities may be reflected in a series of interconnected maps. Species with different disruption patterns in sensory sheets have different matching disruption patterns in the sensory maps and variant individuals and strains of the same species have matching variations in the receptor disruption patterns and their sensory maps. (2) In addition, mutations that misdirect some of the retinal afferents from one side of the brain to the other create new sensory maps that preserve continuities in the altered pattern of input, while creating new structural discontinuities. (3) Furthermore, functionally different classes of afferents that are mixed in the receptor sheet often segregate to activate separate populations of target cells. (4) Finally, early developing portions of receptor sheets may gain more than their share of territory in sensory maps. These and other variable features of sensory maps are most readily accommodated by theories that involve roles for instruction by evoked and spontaneous neural activity patterns. BioEssays 24:334–343, 2002. ©2002 Wiley Periodicals, Inc.
A model for enhancing Internet medical document retrieval with "medical core metadata".

Objective: Finding documents on the World Wide Web relevant to a specific medical information need can be difficult. The goal of this work is to define a set of document content description tags, or metadata encodings, that can be used to promote disciplined search access to Internet medical documents. Design: The authors based their approach on a proposed metadata standard, the Dublin Core Metadata Element Set, which has recently been submitted to the Internet Engineering Task Force. Their model also incorporates the National Library of Medicine's Medical Subject Headings (MeSH) vocabulary and M EDLINE-type content descriptions. Results: The model defines a medical core metadata set that can be used to describe the metadata for a wide variety of Internet documents. Conclusions: The authors propose that their medical core metadata set be used to assign metadata to medical documents to facilitate document retrieval by Internet search engines. n JAMIA. 1999;6:163 - 172.
Modification and psychometric examination of a self-report measure of fear in older adults

The primary purposes of the present study were to: (a) develop a measure of self-reported fear that includes fears that are content valid for older adults, (b) develop an instrument for assessing daily interference associated with fears, and (c) examine the psychometric properties of this new instrument. In the first of two studies, 109 participants, ages 60 through 91, completed a demographic questionnaire and answered an open-ended question about the types of fears they experience. These fears were then included on a modified version of the Fear Survey Schedule-II (Fear Survey Schedule-II for Older Adults (FSS-II-OA)) and administered in a second study. In Study 2, 114 participants (ages 60 through 88) completed a demographic questionnaire, FSS-II-OA, Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), and Penn State Worry Questionnaire (PSWQ), and answered questions regarding fear avoidance. Study 2 revealed high levels of internal consistency and test-retest reliability for total scores on the FSS-II-OA. Test-retest reliability estimates were mixed for individual fear intensity and daily interference items on the FSS-II-OA. Low-moderate to moderate correlations were found between the FSS-II-OA and BAI, BDI-II, and PSWQ.
Effects of species, sex, age, and habitat on geometry of pocket gopher foraging tunnels

Home-range size and shape are influenced by cost–benefit relationships associated with acquiring resources. Subterranean animals may be particularly affected by food availability and soil conditions because of the close coupling of their activity to soil and the high energetic expense of digging. We examined foraging tunnel length, area, and geometry (e.g., number of branches and turning angles) of 3 species of pocket gophers (Geomys attwateri, Geomys bursarius, and Thomomys bottae) in their natural habitats, which differed in food abundance and soil characteristics. Burrow features (except length and area) were similar among species, sexes, ages, and habitats. However, burrows of adults were longer and occupied larger areas than those of juveniles, and burrow system length and area decreased with increasing vegetation biomass and with increasing soil clay content of soil (i.e., increasing expense of digging). Our findings reveal common patterns of burrow geometry, which suggest that there may be an underlying strategy defining geometric features of burrows within this family of subterranean rodents.
The dynamic proteome of Lyme disease Borrelia

The proteome of the spirochete bacterium Borrelia burgdorferi, the tick-borne agent of Lyme disease, has been characterized by two different approaches using mass spectrometry, providing a launching point for future studies on the dramatic changes in protein expression that occur during transmission of the bacterium between ticks and mammals.
An architecture for modular hardware and software fault tolerance in critical real time applications

A modular approach to providing software fault tolerance has been developed by layering this capability onto the C.S. Draper Laboratory (CSDL) Fault Tolerant Processor (FTP) architecture and its Ada RTS to create the Fault Tolerant Processor with Multi-Version Software (FTP-MVS). The FTP-MVS is designed to maintain and extend the high-reliability, low-redundancy management overhead, transparency of redundancy management, and adaptability of the FTP architecture to encompass both hardware and software fault tolerance. FTPs are also used as processing sites within a highly reliable distributed system designed to meet the computational needs of advanced aerospace applications. The FTP-MVS maintains this capability and can provide software fault tolerance Within the distributed processing framework. Such a system addresses both the computational demands of an application and its reliability. >
Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors

Tolfenamic acid (TA) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits lung, esophageal, breast and pancreatic cancer cell and tumor growth, and this study investigated the anticancer activity of TA in colon cancer. TA inhibited growth and induced apoptosis in RKO, SW480, HT-29, and HCT-116 colon cancer cells, and TA (50 mg/kg/d) also inhibited tumor growth in athymic nude mice bearing RKO cells as xenografts. TA downregulated expression of Sp proteins (Sp1, Sp3, and Sp4) in colon cancer cells and this was accompanied by decreased expression of several Sp-regulated growth promoting (cyclin D1, hepatocyte growth factor receptor), angiogenic (vascular endothelial growth factor (VEGF) and its receptor 1), survival (survivin and bcl-2), and inflammatory (NFκBp65/p50) gene products. The mechanism of TA-mediated effects on Sp proteins was due to activation of caspases. These results now extend the number of NSAIDs that may have clinical potential for colon cancer chemotherapy and show that the anticancer activity of TA is due, in part, to targeting Sp transcription factors.
Effects of Intracoronary Radiation on Thrombosis After Balloon Overstretch Injury in the Porcine Model

Background—The main complications of PTCA remain thrombosis and restenosis. Recent studies have demonstrated reduction in the neointimal hyperplasia after intracoronary radiation (IR) with doses of 10 to 25 Gy of ionizing radiation delivered by either β- or γ-emitters to injured vessels. The purpose of this study was to examine the effect of ionizing radiation on the thrombosis rate (TR) of injured porcine coronary arteries. Methods and Results—Thirty-four juvenile swine (63 coronary arteries) were subjected to overstretch balloon injury followed by IR with doses of 0 to 18 Gy of either β- or γ-radiation. Two weeks after treatment, tissue sections were perfusion-fixed, stained with hematoxylin-eosin and Verhoeff–van Gieson’s stain, and analyzed for presence of a thrombus, thrombus morphology, and neointima formation by computer-assisted histomorphometry techniques. Although the overall TR increased dose-dependently from 0 to 18 Gy prescribed dose, luminal thrombi decreased. Thrombus area also decreased wi...
Modified adaptive multiuser detector for DS-CDMA in multipath fading

Direct sequence code division multiple access (DS-CDMA) is the muitiplexing method used for the next generation of wireless digital standards. This paper deals with an asynchronous DS-CDMA system in which the receiver has knowledge of the signature waveform of all the users. In the presence of white Gaussian noise and channel fading, we propose an adaptive suboptimum detector for signal detection during every bit period. The performance of this detector has been compared to the one shot detector under Gaussian noise and channel fading condition.
Effects of Ejaculation by Penile Vibratory Stimulation on Bladder Capacity in Men With Spinal Cord Lesions

ABSTRACTPurpose: We examined the effects of ejaculation by penile vibratory stimulation on bladder capacity in men with spinal cord lesions.Material and Methods: Included in our study were 14 men with spinal cord lesions from C4 to T7 with detrusor hyperreflexia. Cystometry was performed before and immediately after ejaculation by penile vibratory stimulation to establish baseline conditions and repeated after 1 month of ejaculation by penile vibratory stimulation every third day. The third cystometry study was done after 1 month of ejaculation by penile vibratory stimulation every third day at home to determine any long-term effects of treatment. This third cystometry was performed 72 hours after the last ejaculation to exclude any acute effects of ejaculation by penile vibratory stimulation on detrusor hyperreflexia. In addition, 1 to 3 days later ejaculation was induced by penile vibratory stimulation and immediately followed by cystometry to examine whether it was possible to achieve an acute effect a...
The effect of strategic complexity on marketing strategy and organizational performance

Abstract While researchers have examined many antecedents of marketing strategy, there is scant research assessing the effect of organizational cognition. In this study, organizational cognition is examined in terms of the firm's strategic complexity, which is its capacity to integrate multiple environmental dimensions during marketing strategy making. The results from a sample of wholesale distributors reveal four strategic groups that differ based upon their degree of strategic complexity. Results support the proposition that strategic complexity is an organizational capability that enables more effective strategy making and produces superior firm performance.
Stability of n-dimensional patterns in a generalized Turing system: implications for biological pattern formation

The stability of Turing patterns in an n-dimensional cube (0 ,π ) n is studied, where n 2. It is shown by using a generalization of a classical result of Ermentrout concerning spots and stripes in two dimensions that under appropriate assumptions only sheet-like or nodule-like structures can be stable in an n-dimensional cube. Other patterns can also be stable in regions comprising products of lower-dimensional cubes and intervals of appropriate length. Stability results are applied to a new model of skeletal pattern formation in the vertebrate limb.
Modelling of addition polymerization processes — Free radical, ionic, group transfer, and ziegler–natta kinetics

On presente un bref examen des procedes de polymerisation par addition ainsi qu'un resume des principales caracteristiques selon le mecanisme cinetique (radical libre, anionique, cationique, transfert de groupe ou Ziegler-Natta), le comportement de phase et le type de reacteur. Une approche pratique pour la modelisation en milieu industriel est examinee relativement a un progiciel de simulation des procedes de polymerisation
The use of fluorescent antibody technique for the diagnosis of equine histoplasmosis "epizootic lymphangitis".

Summary: The fluorescent antibody technique was evaluated for the first time as a diagnostic aid for the diagnosis of equine histoplasmosis. Sera were obtained from several clinical cases of epizootic lymphangitis. The globulin fraction was separated, quantitated and then labeled with fluoresceine isothiocyanate. Several antigen fmtives were tried. Heat-fixation proved to be the most appropriate. Conjugated sera diluted 1:5 yielded the highest fluorescence intensity with heat fixed mycelial antigen preparations. Acetone and p-formaldehyde treated preparations resulted in less efficient intensity. Glutaraldehyde was the least effective fixative. The test substantiated humoral antibody formation during the course of the infection and its results seem promising for its use as a diagnostic aid. Zusammenfassung: Die Fluoreszenz Antikorpertechnik wurde erstmals als diagnostisches Hilfsmittel bei der Diagnose der Pferdehistoplasmose verwendet. Seren wwden von mehreren klinischen Fallen der epizootischen Lymphangitis gewonnen. Die Globulinfraktion wurde abgetrennt und mit Fluoresceinisothiocat markiert. Mehrere Fixierungsmethoden fur das Antigen wurden untersucht. Die Hitzefixierung erwies sich als am gunstigsten. Konjugierte Seren in einer Verdunnung von 1:5 ergaben die hochsten Fluoreszenzintensitaten mit hitzefixiertem Mgzelantigen. Aceton und Formaldehyd als Fixative ergaben weniger giinstige Resultate. Glutaraldehyd war am wenigsten wirksam. Mit dem Test lies sich die Bildung humoraler Antikorper wahrend des Verlaufs der Infektion nachweisen. Der Test stelit auserdem eine vielversprechende diagnostische Methode dar. Pferdehistoplasmose
Making a Play for Criseyde: The Staging of Pandarus's House in Chaucer's Troilus and Criseyde

provides for the consummation scene in book 3 of Troilus and Criseyde, in which Pandarus first brings Troilus to Criseyde through a trap door from an adjacent stewe (3.741-42) and then, to reassure her that her reputation is not being compromised, offers the false explanation that Troilus secretly entered the house by means of a goter and a pryve wente (3.785-88).' Among the obscure details are such matters as the implied spatial relationships among the rooms and the exact nature of features like the goter and pryve wente. In trying to puzzle these things out, I have been able to supplement H. M. Smyser's influential presentation of the architecture of Pandarus's house2 with new information and interpretations-and with some speculations on the literary function of several of the architectural details that Chaucer gives us: the stewe, the trap door, the goter, and the pryve wente. The accompanying illustrations show a possible layout of Pandarus's house that reflects the analysis that follows here. They are given to help someone unfamiliar with medieval architecture visualize the relative placement of rooms. I want to emphasize that the plans' details are necessarily conjectural; Chaucer does not give any explicit information about the sizes of rooms in Pandarus's house, the precise number and location of doors, windows, and fireplaces, the existence of a privy, and much else. On the other hand, all the particulars are consistent with the details
Late Paleozoic tectonism in Nevada: Timing, kinematics, and tectonic significance

Three late Paleozoic, angular unconformities, each tightly constrained in age by biostratigraphy, are exposed in Carlin Canyon, Nevada. These record deformation as well as erosion. Folding associated with these deformation events is roughly coaxial; all three sets of fold axes trend northeast. Each unconformity represents tectonic disruption of the middle part of the western North American margin between the times of the initiation of the Antler orogeny (Late Devonian–Early Mississippian) and the Permian–Triassic Sonoma orogeny. This paper focuses on one of these unconformities in the Middle Pennsylvanian—the C6 unconformity—and the deformation and age constraints associated with it. Our data from Carlin Canyon yield detailed glimpses of how the Antler foreland evolved tectonically in Mississippian and Pennsylvanian time. Middle Pennsylvanian (Desmoinesian) northwest-southeast contraction resulted in thin-skinned folding and faulting, uplift, and erosion. These data require reinterpretation of the tectonic setting at the time of the Ancestral Rocky Mountains orogeny and suggest that plate convergence on the west side of the continent played a significant role in late Paleozoic tectonics of the North American continent.
Approximation of parabolic PDEs on spheres using spherical basis functions

In this paper we investigate the approximation of a class of parabolic partial differential equations on the unit spheres S n⊂Rn+1 using spherical basis functions. Error estimates in the Sobolev norm are derived.
In vivo conversion of labeled fatty acids to the sphingolipid fatty acids in rat brain

Emulsions of carboxyl-labeled palmitate, stearate, lignocerate, and dl -cerebronate were injected into the brains of weanling rats. After various time intervals, the rats were sacrificed, and the saturated fatty acids of the brain sphingolipids were isolated and decarboxylated. All four acids had been incorporated into the sphingolipids. The palmitate and stearate gave rise to radioactive lignocerate and cerebronate in which the carboxyl groups were relatively nonradioactive, indicating the latter acids are made by chain lengthening of the shorter acids. The lignocerate-C14 gave rise to labeled cerebronate in which the carboxyl group contained nearly all the activity, showing that the normal acid is converted fairly directly into the hydroxy acid. Some radioactivity was found also in the shorter acids, apparently by the intermediate degradation of lignocerate to acetate. The injected cerebronate-C14 underwent little or no conversion to normal acids.
The Creole Connection: What Happens Next?

The purpose of this case is to demonstrate the importance of target market selection and positioning, particularly for businesses in small college towns. Additionally, other marketing and management issues are presented to stimulate understanding of the multitude of variables that impact restaurant success. This case is intended for those interested in marketing, management, entrepreneurship, hotel/restaurant management or retailing areas.
Expanding the Foundation

The archival profession today is doubly challenged. Not only must we deal with dramatic increases in the volume and complexity of paper records, we must also develop programs and strategies for electronic records. The latter, in particular, will require years of research, analysis, testing, and development. However, the resources needed to support years of intensive work in multiple archival settings are not present. The author contends that the profession's most pressing need is the development of greater infrastructure to support research efforts, and she offers examples of the types of organizations that we need to foster.
Methodologies for Isolating Estrogen-Responsive Proteins as Markers of Environmental Toxicants

New and refined methods for the purification of two major estrogen-responsive proteins in murine uterine luminal fluid (ULF) are described. Lacto-ferrin (LF; approx. 70 kDa), was purified using modifications of procedures previously reported. Using column chromatography and electroelution, the protein was purified to a single band demonstrated by gel electrophoresis. An antibody to the purified protein was then raised in rabbits. Rabbit serum was IgG purified and used in Western blotting and immunocytochemical techniques. The serum IgG purified LF antibody demonstrated only one band in Western blotting procedures using enhanced chemiluminescence (ECL) as a detection method. Another estrogen-inducible protein with an approximate molecular weight of 63 kDa in mouse ULF, purified to a single band by gel electrophoresis and electroelution, was determined to be complement C3 through sequence analysis. Similar to LF, C3 has been previously described as an estrogen-responsive protein in the rodent and human repr...
Overview of Diagnostic Imaging of Hip Joint

Since its introduction in the 1970s, MRI has become one of the most powerful imaging tools for musculoskeletal imaging. With state-of-the-art advances in imaging technology, MRI provides remarkable soft tissue contrast with continually improving spatial resolution. MRI is ideally suited to evaluate muscles, tendons, ligaments, and other vital soft tissue structures not easily evaluated by any other imaging technique. MRI does not require ionizing radiation. This is particularly important for patients with chronic conditions who are likely to undergo multiple imaging examinations in their lifetime. With ongoing technologic advancements in MR sequence development, coil manufacturing, and high field strength magnets (e.g., 3.0 T), indications for imaging the hip with MRI continue to expand. It is common for institutions and imaging centers to have a variety of imaging protocols for the hip, utilizing a variety of different coils and often requiring specific magnet strengths (please refer to tables at the end of the chapter for several examples of indication-based protocols). This chapter will focus on the different coils, sequences, and protocols which are useful in imaging the hip.
Validation of a Dosing Strategy for Cefazolin for Surgery Requiring Cardiopulmonary Bypass.

Abstract Background: A prospective, single center, open-label study was conducted to determine if the standard practice for surgical prophylaxis, which includes standardized dosing of cefazolin, at the University of Maryland Medical Center (UMMC) is adequate for patients placed on bypass during cardiac surgery. Methods: All patients were given the same standard dosing regimen regardless of weight: two grams of cefazolin administered within 1 h of incision, an additional one gram injected into the bypass circuit at the onset of bypass, and two grams every 3 h after the initial dose. Cefazolin serum concentrations were collected immediately after incision, after the start of bypass, each hour of bypass, at the end of bypass and at sternal closure. Results: Ten patients were consented and completed the study with an average age of 62 y, average weight of 84.7 kg and average cardiopulmonary bypass time of 116 min. The free serum concentrations of cefazolin stayed above the pre-defined inhibitory threshold of ...
Texas Estate Planning Case Law Update

This article discusses recent judicial developments relating to the Texas law of intestacy, wills, estate administration, trusts, and other estate planning matters. The discussion of each case concludes with a moral, i.e., the important lesson to be learned from the case. By recognizing situations that have led to time consuming and costly litigation in the past, estate planners can reduce the likelihood of the same situations arising with their clients.
Implementing and Evaluating Online Service Learning Projects

As online learning proliferates, professors must adapt traditional projects for an asynchronous environment. Service learning is an effective teaching style fostering interactive learning through integration of classroom activities into communities. While prior studies have documented the appropriateness of service learning in online courses, strategies for implementing and evaluating service learning projects remain limited. The authors detail implementation techniques for including service learning and provide an outline for students and faculty, as well as rubrics for assessing teamwork and for scoring final projects. Results from an implementation in a professional development seminar are presented along with implications for students and communities.
NONCONGLOMERABILITY FOR COUNTABLY ADDITIVE MEASURES THAT ARE NOT κ-ADDITIVE

Let κ be an uncountable cardinal. Using the theory of conditional probability associated with de Finetti (1974) and Dubins (1975), subject to several structural assumptions for creating sufficiently many measurable sets, and assuming that κ is not a weakly inaccessible cardinal, we show that each probability that is not κ-additive has conditional probabilities that fail to be conglomerable in a partition of cardinality no greater than κ. This generalizes a result of Schervish, Seidenfeld, & Kadane (1984), which established that each finite but not countably additive probability has conditional probabilities that fail to be conglomerable in some countable partition.