cssi/SciSciGPT-SciSciNet huggingface dataset:
A type D structure in Khovanov homology

Abstract We describe the first part of a gluing theory for the bigraded Khovanov homology with Z -coefficients. This part associates a type D structure to a tangle properly embedded in a half-space and proves that the homotopy class of the type D structure is an invariant of the isotopy class of the tangle. The construction is modeled off bordered Heegaard–Floer homology, but uses only combinatorial/diagrammatic methods.
Programmable Colloidal Approach to Hierarchical Structures of Methylammonium Lead Bromide Perovskite Nanocrystals with Bright Photoluminescent Properties

Systematic tailoring of nanocrystal architecture could provide unprecedented control over their electronic, photophysical, and charge transport properties for a variety of applications. However, at present, manipulation of the shape of perovskite nanocrystals is done mostly by trial-and-error-based experimental approaches. Here, we report systematic colloidal synthetic strategies to prepare methylammonium lead bromide quantum platelets and quantum cubes. In order to control the nucleation and growth processes of these nanocrystals, we appropriately manipulate the solvent system, surface ligand chemistry, and reaction temperature causing syntheses into anisotropic shapes. We demonstrate that both the presence of chlorinated solvent and a long chain aliphatic amine in the reaction mixture are crucial for the formation of ultrathin quantum platelets (∼2.5 nm in thickness), which is driven by mesoscale-assisted growth of spherical seed nanocrystals (∼1.6 nm in diameter) through attachment of monomers onto sel...
Grading exams: 100,99,98,… or A,B,C?☆

Abstract We introduce grading into games of status. Each player chooses effort, producing a stochastic output or score. Utilities depend on the ranking of all the scores. By clustering scores into grades, the ranking is coarsened, and the incentives to work are changed. We apply games of status to grading exams. Our main conclusion is that if students care primarily about their status (relative rank) in class, they are often best motivated to work not by revealing their exact numerical exam scores ( 100 , 99 , … , 1 ) , but instead by clumping them into coarse categories ( A , B , C ). When student abilities are disparate, the optimal absolute grading scheme is always coarse. Furthermore, it awards fewer A's than there are alpha-quality students, creating small elites. When students are homogeneous, we characterize optimal absolute grading schemes in terms of the stochastic dominance between student performances (when they shirk or work) on subintervals of scores, showing again why coarse grading may be advantageous. In both cases, we prove that absolute grading is better than grading on a curve, provided student scores are independent.
Distributed Statistical Machine Learning in Adversarial Settings: Byzantine Gradient Descent

We consider the distributed statistical learning problem over decentralized systems that are prone to adversarial attacks. This setup arises in many practical applications, including Google's Federated Learning. Formally, we focus on a decentralized system that consists of a parameter server and m working machines; each working machine keeps N/m data samples, where N is the total number of samples. In each iteration, up to q of the m working machines suffer Byzantine faults -- a faulty machine in the given iteration behaves arbitrarily badly against the system and has complete knowledge of the system. Additionally, the sets of faulty machines may be different across iterations. Our goal is to design robust algorithms such that the system can learn the underlying true parameter, which is of dimension d, despite the interruption of the Byzantine attacks. In this paper, based on the geometric median of means of the gradients, we propose a simple variant of the classical gradient descent method. We show that our method can tolerate q Byzantine failures up to 2(1+e)q le m for an arbitrarily small but fixed constant e>0. The parameter estimate converges in O(log N) rounds with an estimation error on the order of max √dq/N, ~√d/N , which is larger than the minimax-optimal error rate √d/N in the centralized and failure-free setting by at most a factor of √q . The total computational complexity of our algorithm is of O((Nd/m) log N) at each working machine and O(md + kd log 3 N) at the central server, and the total communication cost is of O(m d log N). We further provide an application of our general results to the linear regression problem. A key challenge arises in the above problem is that Byzantine failures create arbitrary and unspecified dependency among the iterations and the aggregated gradients. To handle this issue in the analysis, we prove that the aggregated gradient, as a function of model parameter, converges uniformly to the true gradient function.
Using Interactive Narrative in Health Interventions: A Drama Manager Approach

In this work, we propose integrating a drama manager into a visual novel to guide both storytelling and health intervention. We discuss certain narrative structures that can be used to guide a visual-novel-based health intervention and can potentially benefit future drama manager research.
In vitro performance of near infrared light transillumination at 780-nm and digital radiography for detection of non-cavitated approximal caries.

Abstract Objectives To evaluate the ability of a Near Infrared Light Transillumination (NILT) device to detect non-cavitated approximal caries lesions; and to compare its performance to Digital Radiography (DR). Methods Thirty human extracted premolars (sound to lesions into the outer one-third of dentin) were selected. Lesion depth was confirmed by micro-computed tomography (μ-CT). Teeth were mounted in a custom-made device to simulate approximal contact. DR and NILT (CariVu™, DEXIS, LLC, Hatfield, PA, USA) examinations were performed and repeated by three trained and calibrated examiners. Sensitivity, specificity, area under ROC curve (A z ), inter- and intra-class correlation coefficients (ICCs) for each method, and correlation among the methods were determined. Results ICCs for intra-/inter-examiner agreement were substantial for NILT (0.69/0.64), and moderate for DR (0.52/0.48). Sensitivity/specificity for NILT and DR were 0.68/0.93 and 0.50/0.64, respectively. A z for NILT was 0.81, while for DR it was 0.61. Spearman correlation coefficient with μ -CT for NILT (0.65, p Conclusion Within the limitations of this in vitro study, NILT demonstrated a potential for early approximal caries detection. NILT and DR performed the same regarding the accuracy for non-cavitated approximal caries detection; however, NILT was superior to DR in terms of repeatability, agreement and correlation with μ -CT. Clinical significance A commercial version of NILT was recently introduced as a non-irradiative adjunctive caries detection method. It uses near infrared (NIR) light at 780-nm to transilluminate teeth and captures live images from the occlusal surface. This study demonstrates that NILT can be used as an alternative to radiography for non-cavitated approximal caries detection.
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota

Background & Aims Intestinal epithelial homeostasis is maintained by complex interactions among epithelial cells, commensal gut microorganisms, and immune cells. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD), but the mechanisms of this process are not clear. We investigated how Sirtuin 1 (SIRT1), a conserved mammalian NAD + -dependent protein deacetylase, senses environmental stress to alter intestinal integrity. Methods We performed studies of mice with disruption of Sirt1 specifically in the intestinal epithelium (SIRT1 iKO, villin-Cre+, Sirt1 flox/flox mice) and control mice (villin-Cre-, Sirt1 flox/flox ) on a C57BL/6 background. Acute colitis was induced in some mice by addition of 2.5% dextran sodium sulfate to drinking water for 5–9 consecutive days. Some mice were given antibiotics via their drinking water for 4 weeks to deplete their microbiota. Some mice were fed with a cholestyramine-containing diet for 7 days to sequester their bile acids. Feces were collected and proportions of microbiota were analyzed by 16S rRNA amplicon sequencing and quantitative PCR. Intestines were collected from mice and gene expression profiles were compared by microarray and quantitative PCR analyses. We compared levels of specific mRNAs between colon tissues from age-matched patients with ulcerative colitis (n=10) vs without IBD (n=8, controls). Results Mice with intestinal deletion of SIRT1 (SIRT1 iKO) had abnormal activation of Paneth cells starting at the age of 5–8 months, with increased activation of NF-κB, stress pathways, and spontaneous inflammation at 22–24 months of age, compared with control mice. SIRT1 iKO mice also had altered fecal microbiota starting at 4–6 months of age compared with control mice, in part because of altered bile acid metabolism. Moreover, SIRT1 iKO mice with defective gut microbiota developed more severe colitis than control mice. Intestinal tissues from patients with ulcerative colitis expressed significantly lower levels of SIRT1 mRNA than controls. Intestinal tissues from SIRT1 iKO mice given antibiotics, however, did not have signs of inflammation at 22–24 months of age, and did not develop more severe colitis than control mice at 4–6 months. Conclusions In analyses of intestinal tissues, colitis induction, and gut microbiota in mice with intestinal epithelial disruption of SIRT1, we found this protein to prevent intestinal inflammation by regulating the gut microbiota. SIRT1 might therefore be an important mediator of host–microbiome interactions. Agents designed to activate SIRT1 might be developed as treatments for IBDs.
Theorization and an Empirical Investigation of the Component-Based and Developmental Text Writing Fluency Construct.

We discuss a component-based, developmental view of text writing fluency, which we tested using data from children in Grades 2 and 3. Text writing fluency was defined as efficiency and automaticity in writing connected texts, which acts as a mediator between text generation (oral language), transcription skills, and writing quality. We hypothesized that in the beginning phase, text writing fluency would be largely constrained by transcription skills (spelling and handwriting), while at a later phase, oral language would make an independent contribution to text writing fluency. Furthermore, we hypothesized that text writing fluency would have a stronger relationship with writing quality at a later phase than at an earlier phase. We operationalized text writing fluency using two curriculum-based measurement writing scores: percentage correct word sequences and correct minus incorrect word sequences. Results revealed that in Grade 2, only transcription skills were uniquely related to text writing fluency, wh...
Effect of Route of Administration on the Selectivity of Hematoporphyrin Derivative for Tumor Tissue

Hematoporphyrin derivative (HPD) has the ability to localize with moderate selectivity to tumor tissue, where it can be activated by visible light and produce singlet oxygen-mediated damage to cellular biomolecules. However, HPD is less than ideal as an agent for tumor photoradiation therapy because it produces a period of photosensitivity that can last 30 days or more, and it can be toxic to surrounding tissues such as skin when used in the treatment of subcutaneous metastases. The usefulness of intra-arterial injection for refining the selectivity of HPD was investigated in this work. Intraarterial administration of HPD was not found to provide higher tumor levels of HPD, nor was it able to increase significantly the concentration of HPD relative to surrounding tissues, such as skin and muscle. However, fluorescence microscopy findings suggested that some fluorescent HPD component is rapidly accumulated in tumor macrophages following intraarterial injection.
Transmission of Genital Herpes in Couples With One Symptomatic and One Asymptomatic Partner: A Prospective Study

To determine the risk of transmission of genital herpes simplex virus (HSV) infection, we prospectively studied, for a median of six months, 38 couples who had been together for a median of 10 mo. In each couple, one partner had a history of symptomatic genital herpes and one did not. At entry, of the 38 asymptomatic, exposed partners, 21 were seronegative, and results of western blot analysis showed that seven had antibody to HSV type 1 (HSV-1), four to HSV type 2 (HSV-2), and six to both HSV-1 and HSV-2. One of the 28 exposed partners without antibody to HSV-2 at enrollment asymptomatically acquired HSV-2 infection, but four of 10 with antibody to HSV-2 at enrollment developed culture-proven HSV-2 infection during follow-up. Restriction endonuclease analysis of DNA from paired isolates revealed identical strains in three couples and different strains in one. In this group of asymptomatic sex partners of persons with genital herpes, asymptomatic and unrecognized acquisition of HSV-2 infection was common, but more than half of the exposed partners remained free of HSV-2 infection after a median of 16 mo of sexual contact.
Suppressor Substance Produced by the K562 Cell Line In Vitro

Supernatant fluids from three human cultured cell lines, K562, NALM-1, and Daudi, all isolated from patients with lymphoreticular malignancies, were tested for suppressive activity toward normal lymphocytes in vitro. It was found that the K562 line elaborated material which effectively suppressed the response of normal human blood lymphocytes to the T-cell mitogens phytohemagglutinin and concanaval in A as well as the mixed lymphocyte reaction. Little or no suppressive activity was evident when supernatants from Daudi or NALM-1 were used. In contrast, a recent report [29] indicates that K562 does not inhibit the induction of immunoglobulin synthesis of B lymphocytes by pokeweed mitogen. The findings are discussed in the context of the immunosuppression associated with cancer and the apparent selective inhibition of different lymphocyte functions by material elaborated by different neoplasms.
Vision-based target tracking and autonomous landing of a quadrotor on a ground vehicle

This paper addresses vision-based tracking and landing of a micro-aerial vehicle (MAV) on a ground vehicle (GV). The camera onboard the MAV is mounted so that the optical axis is aligned with the downward-facing axis of the body-fixed frame. A novel supervised learning vision algorithm is proposed as the method to detect the ground vehicle in the image frame. A feedback linearization technique is developed for the MAV to fly over and track the GV so that visibility with the tracked target is maintained with certain guarantees. The efficacy of the visual detection algorithm, and of the tracking and landing controller is demonstrated in simulations and experiments with static and mobile GV.
Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery

Mammalian cells respond to double-stranded RNA (dsRNA) by activating a translation-inhibiting endoribonuclease, RNase L. Consensus in the field indicates that RNase L arrests protein synthesis by degrading ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs). However, here we provide evidence for a different and far more efficient mechanism. By sequencing abundant RNA fragments generated by RNase L in human cells, we identify site-specific cleavage of two groups of noncoding RNAs: Y-RNAs, whose function is poorly understood, and cytosolic tRNAs, which are essential for translation. Quantitative analysis of human RNA cleavage versus nascent protein synthesis in lung carcinoma cells shows that RNase L stops global translation when tRNAs, as well as rRNAs and mRNAs, are still intact. Therefore, RNase L does not have to degrade the translation machinery to stop protein synthesis. Our data point to a rapid mechanism that transforms a subtle RNA cleavage into a cell-wide translation arrest.
Some observations on holographic algorithms

We define the notion of diversity for families of finite functions and express the limitations of a simple class of holographic algorithms, called elementary algorithms, in terms of limitations on diversity. We show that this class of elementary algorithms is too weak to solve the Boolean circuit value problem, or Boolean satisfiability, or the permanent. The lower bound argument is a natural but apparently novel combination of counting and algebraic dependence arguments that is viable in the holographic framework. We go on to describe polynomial time holographic algorithms that go beyond the elementarity restriction in the two respects that they use exponential size fields, and multiple oracle calls in the form of polynomial interpolation. These new algorithms, which use bases of three components, compute the parity of the following quantities for degree three planar undirected graphs: the number of 3-colorings up to permutation of colors, the number of connected vertex covers, and the number of induced forests or feedback vertex sets. In each case, the parity can also be computed for any one slice of the problem, in particular for colorings where the first color is used a certain number of times, or where the connected vertex cover, feedback set or induced forest has a certain number of nodes.
Programmable RNA recognition using a CRISPR-associated Argonaute.

Argonaute proteins (Agos) are present in all domains of life. Although the physiological function of eukaryotic Agos in regulating gene expression is well documented, the biological roles of many of their prokaryotic counterparts remain enigmatic. In some bacteria, Agos are associated with CRISPR (clustered regularly interspaced short palindromic repeats) loci and use noncanonical 5′-hydroxylated guide RNAs (gRNAs) for nucleic acid targeting. Here we show that using 5-bromo-2′-deoxyuridine (BrdU) as the 5′ nucleotide of gRNAs stabilizes in vitro reconstituted CRISPR-associated Marinitoga piezophila Argonaute–gRNA complexes (MpAgo RNPs) and significantly improves their specificity and affinity for RNA targets. Using reconstituted MpAgo RNPs with 5′-BrdU-modified gRNAs, we mapped the seed region of the gRNA and identified the nucleotides of the gRNA that play the most significant role in targeting specificity. We also show that these MpAgo RNPs can be programmed to distinguish between substrates that differ by a single nucleotide, using permutations at the sixth and seventh positions in the gRNA. Using these specificity features, we employed MpAgo RNPs to detect specific adenosine-to-inosine–edited RNAs in a complex mixture. These findings broaden our mechanistic understanding of the interactions of Argonautes with guide and substrate RNAs, and demonstrate that MpAgo RNPs with 5′-BrdU-modified gRNAs can be used as a highly specific RNA-targeting platform to probe RNA biology.
WHAT'S TO KNOW? PUZZLES IN THE LITERATURE ON THE VALUE OF STATISTICAL LIFE

Notwithstanding the general acceptance of the value of statistical life (VSL) estimates for policy assessment purposes, several important unresolved issues remain. First, the results from revealed preference studies are systematically higher than those from stated preference studies, potentially limiting the usefulness of stated preference studies in generalizing the VSL estimates to different populations and kinds of risks. Second, extrapolating the results of meta-analyses to project the VSL for different population groups requires that such generalization be reflective of the underlying economic content of what average VSL estimates reflect. Third, government agencies within and across countries place differing emphasis on types of VSL studies as well as differing reliance on individual studies versus meta-analyses. Usually, there is no justification provided for the chosen approach.
Low Serum Pancreatic Amylase and Lipase Values Are Simple and Useful Predictors to Diagnose Chronic Pancreatitis.

Background/Aims: This study aimed to evaluate the diag- nostic role of low serum amylase and lipase values in the detection of chronic pancreatitis. Methods: Patients under went endoscopic retrograde cholangiopancreatography and were diagnosed with non-calcific chronic pancreatitis (NCCP; n=99) and calcific chronic pancreatitis (CCP; n=112). Patient serum amylase and lipase values were compared with those of healthy controls (H; n=170). Results: The median serum amylase (normal range, 19 to 86 U/L) and lipase values (7 to 59 U/L) (P25-P75) were 47.0 (39.8 to 55.3) and 25.0 (18.0 to 35.0) for H, 34.0 (24.5 to 49.0) and 19.0 (9.0 to 30.0) for NCCP, and 30.0 (20.0 to 40.8) and 10.0 (3.0 to 19.0) for CCP, respectively. The cutoff values with the highest diagnos tic accuracy for discriminating NCCP from H were 40 U/L for amylase and 20 U/L for lipase, respectively, and for CCP from H were 38 U/L for amylase and 15 U/L for lipase, respec tively. For the diagnosis of NCCP with a criterion of serum amylase <40 and lipase <20 U/L, the sensitivity, specificity, positive predictive value, and negative predictive values were 37.4%, 88.8%, 66.1%, and 70.9%, respectively. Conclusions: Serum amylase and/or lipase levels below the normal serum range are highly specific for chronic pancreatitis patients. Clinicians should not ignore low serum pancreatic enzyme values. (Gut Liver 2017;11:878-883)
Ultracompact Amplitude Modulator by Coupling Hyperbolic Polaritons over a Graphene-Covered Gap

The hyperbolic phonon-polaritons within the Reststrahlen band of hBN are of great interest for applications in nanophotonics, as they are capable of propagating light signals with low losses over large distances. However, due to the phononic nature of the polaritons in hBN, amplitude modulation of its signal proves to be difficult and has been underexplored. In this paper, we propose theoretically a broadband efficient amplitude modulator for hyperbolic rays in hBN operating in the frequency range between 1450 and 1550 cm–1. The modulating region comprises a few tens of nanometers wide gap carved within the hBN slab and covered by a graphene layer, where electrostatically gated graphene serves as a mediator that facilitates the coupling between phonon-polaritons on each side of the gap through plasmonic modes within graphene. We demonstrate that such an ultracompact modulator has insertion losses as low as 3 dB and provides modulation depth varying between 14 and 20 dB within the type-II hyperbolicity reg...
Liability for Providing Hyperlinks to Copyright-Infringing Content: International and Comparative Law Perspectives

Hyperlinking, at once an essential means of navigating the Internet, but also a frequent means to enable infringement of copyright, challenges courts to articulate the legal norms that underpin domestic and international copyright law, in order to ensure effective enforcement of exclusive rights on the one hand, while preserving open communication on the Internet on the other. Several recent cases, primarily in the European Union, demonstrate the difficulties of enforcing the right of communication to the public (or, in U.S. copyright parlance, the right of public performance by transmission) against those who provide hyperlinks that effectively deliver infringing content to Internet users. This Article will first address the international norms that domestic laws of states members to the multilateral copyright agreements must implement. It next will explore how two of the most significant regional or national copyright regimes, the E.U. and the U.S., have coped with the question of linking, and then will consider the relationship of the emerging approaches to copyright infringement with national and regional laws instituting limited immunity for copyright infringements committed by internet service providers. We will conclude with an assessment of the extent to which the outcomes under U.S. and E.U. regimes, despite their apparently different approaches, in fact converge.
Self-Adapted Floquet Dynamics of Ultracold Bosons in a Cavity

Floquet dynamics of a quantum system subject to periodic modulations of system parameters provides a powerful tool for engineering new quantum matter with exotic properties. While system dynamics is significantly altered, the periodic modulation itself is usually induced externally and independent of Floquet dynamics. Here we propose a new type of Floquet physics for a Bose-Einstein condensate (BEC) subject to a shaken lattice generated inside a cavity, where the shaken lattice and atomic Floquet bands are mutually dependent, resulting in self-adapted Floquet dynamics. In particular, the shaken lattice induces Floquet quasienergy bands for the BEC, whose backaction leads to a self-adapted dynamical normal-superradiant phase transition for the shaken lattice. Such self-adapted Floquet dynamics shows two surprising and unique features: (i) The normal-superradiant phase transition possesses a hysteresis even without atom interactions. (ii) The dynamical atom-cavity steady state could exist at free energy maxima. The atom interactions strongly affect the phase transition of the BEC from zero to finite momenta. Our results provide a powerful platform for exploring self-adapted Floquet physics, which may open an avenue for engineering novel quantum materials.
On the Convergence of Adam and Beyond

Several recently proposed stochastic optimization methods that have been successfully used in training deep networks such as RMSProp, Adam, Adadelta, Nadam are based on using gradient updates scaled by square roots of exponential moving averages of squared past gradients. In many applications, e.g. learning with large output spaces, it has been empirically observed that these algorithms fail to converge to an optimal solution (or a critical point in nonconvex settings). We show that one cause for such failures is the exponential moving average used in the algorithms. We provide an explicit example of a simple convex optimization setting where Adam does not converge to the optimal solution, and describe the precise problems with the previous analysis of Adam algorithm. Our analysis suggests that the convergence issues can be fixed by endowing such algorithms with `long-term memory' of past gradients, and propose new variants of the Adam algorithm which not only fix the convergence issues but often also lead to improved empirical performance.
Orthogonally Regularized Deep Networks for Image Super-Resolution

Deep learning methods, in particular trained Convolutional Neural Networks (CNNs) have recently been shown to produce compelling state-of-the-art results for single image Super-Resolution (SR). Invariably, a CNN is learned to map the low resolution (LR) image to its corresponding high resolution (HR) version in the spatial domain. Aiming for faster inference and more efficient solutions than solving the SR problem in the spatial domain, we propose a novel network structure for learning the SR mapping function in an image transform domain, specifically the Discrete Cosine Transform (DCT). As a first contribution, we show that DCT can be integrated into the network structure as a Convolutional DCT (CDCT) layer. We further extend the network to allow the CDCT layer to become trainable (i.e. optimizable). Because this layer represents an image transform, we enforce pairwise orthogonality constraints on the individual basis functions/filters. This Orthogonally Regularized Deep SR network (ORDSR) simplifies the SR task by taking advantage of image transform domain while adapting the design of transform basis to the training image set. Experimental results show ORDSR achieves state-of-the-art SR image quality with fewer parameters than most of the deep CNN methods.
The persistence of preschool effects from early childhood through adolescence

Using data from the Early Childhood Longitudinal Study Kindergarten Cohort of 1998 (n = 15,070), this study used propensity scores to examine the short- and long-term academic and psychosocial benefits of preschool education for a diverse sample of middle-class children. Compared with children who attended informal care at age 4, preschool attendees consistently performed better on achievement tests from age 5 through early adolescence, but exhibited less optimal psychosocial skills. These negative behavioral effects of preschool were concentrated among children who attended preschool for 20 or more hours per week, but otherwise, there was little evidence of heterogeneity as a function of program type or child- and family-characteristics. The long-term academic advantages of preschool were, however, largely explained by their positive effects on academic skills early in formal schooling and there was evidence for convergence in children's academic test scores, which was partially attributed to the differences in children's social skills during the early elementary school years.
Coherent Directional Supercontinuum Generation

We present a novel approach for coherent, directional supercontinuum and cascaded dispersive waves in dispersion-engineered waveguides. Operating in the normal group-velocity-dispersion regime, we demonstrate octave-spanning spectra generated primarily to one side of the pump.
Chronic kidney disease and peripheral nerve function in the Health, Aging and Body Composition Study

BACKGROUND Chronic kidney disease (CKD) is associated with poor mobility. Peripheral nerve function alterations play a significant role in low mobility. We tested the hypothesis that early CKD is associated with altered sensory, motor and autonomic nerve function. METHODS Participants in the Health, Aging and Body Composition cohort who had kidney function measures in Year 3 (1999-2000) and nerve function measurements at Year 4 (2000-01) were analyzed (n = 2290). Sensory (vibration threshold, monofilament insensitivity to light and standard touch), motor [compound motor action potentials (CMAPs), nerve conduction velocities (NCVs)] and autonomic (heart rate response and recovery after a 400-m walk test) nerve function as well as participant characteristics were compared across cystatin C- and creatinine-based estimated glomerular filtration rate categorized as ≤60 (CKD) or >60 mL/min/1.73 m2 (non-CKD). The association between CKD and nerve function was examined with logistic regression adjusted for covariates. RESULTS Participants with CKD (n = 476) were older (77 ± 3 versus 75 ± 3 years; P < 0.05) and had a higher prevalence of diabetes (20.6% versus 13.1%; P < 0.001). CKD was associated with higher odds for vibration detection threshold {odds ratio [OR] 1.7 [95% confidence interval (CI) 1.1-2.7]} and light touch insensitivity [OR 1.4 (95% CI 1.1-1.7)]. CMAPs and NCVs were not significantly different between CKD and non-CKD patients. In adjusted analyses, participants with CKD had higher odds of an abnormal heart rate response [OR 1.6 (95% CI 1.1-2.2)] and poor heart rate recovery [OR 1.5 (95% CI 1.1-2.0)]. CONCLUSIONS CKD is associated with changes in sensory and autonomic nerve function, even after adjustment for demographics and comorbidities, including diabetes. Longitudinal studies in CKD are needed to determine the contribution of nerve impairments to clinically important outcomes.
An update on speculation and financialization in commodity markets

Abstract This paper reviews the more recent literature addressing different facets of speculation in commodity markets, including the role of speculators and the impact that financialization in recent years. While speculation and financialization can theoretically destabilize commodity markets, the extant literature finds little evidence of destabilization and documents that speculators largely provide liquidity to hedgers. Moreover, recent concern that commodity index trading leads to price distortions has little support in the data.
Method for Estimating Consumptive Use of Water for Agriculture

Monthly and annual estimates in planning of irrigation projects; data on measured rates of consumptive use of water and on estimated consumptive use determined by various formulas; procedure for determining monthly and annual water requirements on project basis from climatological data for areas where measurements of consumptive use are not available; procedure is called Precipitation Evaporation or P.E.Index Method.
Gods’ homes, men’s courts, women’s rights

For decades, the Hindu temple at Sabarimala has drawn media attention and the occasional lawsuit because of its ban on women aged ten to fifty. Most recently, popular campaigns for expanding women’s access to temples have revived a twelve-year-old public interest suit before the Indian Supreme Court. The petitioners in that suit argue that Sabarimala’s ban, though earlier recognized as an “essential practice” of Ayyappan worship, violates constitutional guarantees of equality and religious freedom. Opponents counter that the ban is in keeping with constitutional guarantees that religious denominations may govern their internal affairs and keep control over their religious institutions. This article provides a “state of the field” overview with respect to essential practices jurisprudence and the Sabarimala dispute on women’s entry, drawing on case law and media coverage to construct a history of the Sabarimala dispute writ large and to contextualize the current litigation within that broader history.
Information Aging Through Queues: A Mutual Information Perspective

In this paper, we propose a new measure for the freshness of information, which uses the mutual information between the real-time source value and the delivered samples at the receiver to quantify the freshness of the information contained in the delivered samples. Hence, the “aging” of the received information can be interpreted as a procedure that the above mutual information reduces as the age grows. In addition, we consider a sampling problem, where samples of a Markov source are taken and sent through a queue to the receiver. In order to optimize the freshness of information, we study the optimal sampling policy that maximizes the time-average expected mutual information. We prove that the optimal sampling policy is a threshold policy and find the optimal threshold exactly. Specifically, a new sample is taken once a conditional mutual information reduces to a threshold, and the threshold is equal to the optimum value of the time-average expected mutual information that is being maximized. Numerical results are provided to compare different sampling policies.
Sequential Empirical Coordination Under an Output Entropy Constraint

This paper considers the problem of sequential empirical coordination, where the objective is to achieve a given value of the expected uniform deviation between the state-action empirical averages and the statistical expectations under a given strategic probability measure with respect to a given universal Glivenko–Cantelli class of test functions. A communication constraint is imposed on the Shannon entropy of the resulting action sequence. It is shown that the fundamental limit on the output entropy is given by the minimum of the mutual information between the state and the action processes under all strategic measures that have the same marginal state process as the target measure and approximate the target measure to desired accuracy with respect to the underlying Glivenko–Cantelli seminorm. The fundamental limit is shown to be asymptotically achievable by the tree-structured codes.
A team effort: natural killer cells on the first leg of the tumor immunity relay race.

Recent work by Bottcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tumor immunity. This work highlights the cooperative nature of anti-tumor immunity set in motion by Natural Killer cells, and immune evasion by tumors through their exclusion.
On the Complexity of Compressing Obfuscation

Indistinguishability obfuscation has become one of the most exciting cryptographic primitives due to its far reaching applications in cryptography and other fields. However, to date, obtaining a plausibly secure construction has been an illusive task, thus motivating the study of seemingly weaker primitives that imply it, with the possibility that they will be easier to construct.
Low-Resource Contextual Topic Identification on Speech

In topic identification (topic ID) on real-world unstructured audio, an audio instance of variable topic shifts is first broken into sequential segments, and each segment is independently classified. We first present a general purpose method for topic ID on spoken segments in low-resource languages, using a cascade of universal acoustic modeling, translation lexicons to English, and English-language topic classification. Next, instead of classifying each segment independently, we demonstrate that exploring the contextual dependencies across sequential segments can provide large improvements. In particular, we propose an attention-based contextual model which is able to leverage the contexts in a selective manner. We test both our contextual and non-contextual models on four LORELEI languages, and on all but one our attention-based contextual model significantly outperforms the context-independent models.
Energetic ion dynamics near Callisto

Abstract We examine the dynamics of energetic magnetospheric ions in the highly perturbed and asymmetric electromagnetic environment of the Jovian moon Callisto. The Alfvenic interaction of the (nearly) corotating magnetospheric plasma with Callisto's ionosphere and induced dipole generates electromagnetic field perturbations near the moon, the structure of which vary as a function of Callisto's orbital position. For this study, these perturbations are obtained from the AIKEF hybrid model (kinetic ions, fluid electrons) which has already been successfully applied to Callisto's local plasma environment (Liuzzo et al., 2015, 2016, 2017). To isolate the influence of Callisto's ionosphere and induced dipole field on energetic ion dynamics, we analyze the trajectories of energetic hydrogen, oxygen, and sulfur ions exposed to various configurations of the locally perturbed electromagnetic fields. We present spatially resolved surface maps that display accessibility of Callisto to these ion populations for select energies from 1 keV to 5000 keV. The Alfvenic plasma interaction with (i) Callisto's induced magnetic field, (ii) Callisto's ionosphere, and (iii) the combination of both, all leave distinct imprints in these accessibility patterns. Draping of the magnetospheric field around Callisto's ionosphere partially shields the moon's trailing (ramside) hemisphere from energetic ion impacts, and the induced field tends to focus energetic ion impacts near Callisto's Jupiter-facing and Jupiter-averted apices. Depending on the nature of Callisto's Alfvenic plasma interaction, the accessibility of its surface to energetic protons may evolve non-monotonically with increasing energy. We also present maps of energetic ion accessibility and the resulting energy deposition onto Callisto at the time of the Galileo C3, C9, and C10 flybys. Our findings show that the shielding of Callisto's surface from energetic ion impacts is most effective during flybys that took place while the moon was located at an intermediate distance to the center of Jupiter's magnetospheric current sheet. In this case, the ionosphere and induced dipole field both make substantial contributions to the electromagnetic field perturbations near Callisto.
Kid on the phone! Toward automatic detection of children on mobile devices

Abstract Studies have shown that children can be exposed to smart devices at a very early age. This has important implications on research in children–computer interaction, children online safety and early education. Many systems have been built based on such research. In this work, we present multiple techniques to automatically detect the presence of a child on a smart device, which could be used as the first step on such systems. Our methods distinguish children from adults based on behavioral differences while operating a touch-enabled modern computing device. Behavioral differences are extracted from data recorded by the touchscreen and built-in sensors. To evaluate the effectiveness of the proposed methods, a new data set has been created from 50 children and adults who interacted with off-the-shelf applications on smart phones. Results show that it is possible to achieve 99% accuracy and less than 0.5% error rate after 8 consecutive touch gestures using only touch information or 5 s of sensor reading. If information is used from multiple sensors, then only after 3 gestures, similar performance could be achieved.
Maximum Area Axis-Aligned Square Packings.

Given a point set S={s_1,... , s_n} in the unit square U=[0,1]^2, an anchored square packing is a set of n interior-disjoint empty squares in U such that s_i is a corner of the ith square. The reach R(S) of S is the set of points that may be covered by such a packing, that is, the union of all empty squares anchored at points in S. It is shown that area(R(S))>= 1/2 for every finite set S subset U, and this bound is the best possible. The region R(S) can be computed in O(n log n) time. Finally, we prove that finding a maximum area anchored square packing is NP-complete. This is the first hardness proof for a geometric packing problem where the size of geometric objects in the packing is unrestricted.
A denotation-driven reanalysis of the Spanish neuter pronominal system

This paper offers an analysis of the Spanish neuter pronominal system that complements the system found in traditional Spanish grammars. A more descriptively and heuristically adequate analysis is proposed that includes pro-forms widely ignored in previous accounts such as phonetically null pronouns and explains a wider range of neuter reference uses, denotations and constructions. I base my analysis on two main basic assumptions. First, I claim that some neuter pronouns can be used either referentially or non-referentially. Following Moltmann's (2013) semantic analysis of presentational pronouns, I argue that the pronoun ‘lo’ that we find in free relative constructions does not have a referential denotation but only a presentational denotation. Second, all neuter pronouns share a common semantic specification as [−individual] expressions in contrast with non-neuter pronouns, which are unspecified for the same feature. This specification allows us to establish a clear division of labor between the so-called neuter and non-neuter reference in Spanish at the pronominal level. I also claim that neuter pronouns have the ability to shift the type of the entity referred to from individuals to properties or sets of properties. This is particularly evident with neuter demonstrative pronouns in uses such as ‘eso es mi coche’ (that is my car) or ‘eso es una mujer’ (that is a woman), which are fairly common in natural discourse. The proposed analysis is framed within a general theory of definiteness (Roberts, 2003) and aligns with the theories of referent accessibility such as the Givenness Hierarchy (Gundel et al., 1993), which allows an explanation for how semantically similar neuter forms encode the cognitive status of their referents differently.
Intercomparison between Switch 2.0 and GE MAPS Models for Simulation of High-Renewable Power Systems in Hawaii

New open-source electric-grid planning models have the potential to improve power system planning and bring a wider range of stakeholders into the planning process for next-generation, high-renewable power systems. However, it has not yet been established whether open-source models perform similarly to the more established commercial models for power system analysis. This reduces their credibility and attractiveness to stakeholders, postponing the benefits they could offer. In this paper, we report the first model intercomparison between an open-source power system model and an established commercial production cost model. We compare the open-source Switch 2.0 to GE Energy Consulting’s Multi-Area Production Simulation (MAPS) for production-cost modeling, considering hourly operation under 17 scenarios of renewable energy adoption in Hawaii. We find that after configuring Switch with similar inputs to MAPS, the two models agree closely on hourly and annual production from all power sources. Comparing production gave a coefficient of determination of 0.996 across all energy sources and scenarios, indicating that the two models agree on 99.6% of the variation. For individual energy sources, the coefficient of determination was 69–100. Although some disagreement remains between the two models, this work indicates that Switch is a viable choice for renewable integration modeling, at least for the small power systems considered here.
Vanished Classmates: The Effects of Local Immigration Enforcement on Student Enrollment

For over a decade, Immigration and Customs Enforcement (ICE) has formed partnerships allowing local police to enforce immigration law by identifying and arresting undocumented residents. Prior stud...
An Empirical Study of the I2P Anonymity Network and its Censorship Resistance

Tor and I2P are well-known anonymity networks used by many individuals to protect their online privacy and anonymity. Tor's centralized directory services facilitate the understanding of the Tor network, as well as the measurement and visualization of its structure through the Tor Metrics project. In contrast, I2P does not rely on centralized directory servers, and thus obtaining a complete view of the network is challenging. In this work, we conduct an empirical study of the I2P network, in which we measure properties including population, churn rate, router type, and the geographic distribution of I2P peers. We find that there are currently around 32K active I2P peers in the network on a daily basis. Of these peers, 14K are located behind NAT or firewalls. Using the collected network data, we examine the blocking resistance of I2P against a censor that wants to prevent access to I2P using address-based blocking techniques. Despite the decentralized characteristics of I2P, we discover that a censor can block more than 95% of peer IP addresses known by a stable I2P client by operating only 10 routers in the network. This amounts to severe network impairment: a blocking rate of more than 70% is enough to cause significant latency in web browsing activities, while blocking more than 90% of peer IP addresses can make the network unusable. Finally, we discuss the security consequences of the network being blocked, and directions for potential approaches to make I2P more resistant to blocking.
Cul4-Ddb1 ubiquitin ligases facilitate DNA replication-coupled sister chromatid cohesion through regulation of cohesin acetyltransferase Esco2

Cohesin acetyltransferases ESCO1 and ESCO2 play a vital role in establishing sister chromatid cohesion. How ESCO1 and ESCO2 are controlled in a DNA replication-coupled manner remains unclear in higher eukaryotes. Here we show a critical role of CUL4-RING ligases (CRL4s) in cohesion establishment via regulating ESCO2 in human cells. Depletion of CUL4A, CUL4B or DDB1 subunits substantially reduces the normal cohesion efficiency. We also show that MMS22L, a vertebrate ortholog of yeast Mms22, is one of DDB1 and CUL4-associated factors (DCAFs) involved in cohesion. Several lines of evidence show selective interaction of CRL4s with ESCO2 through LxG motif, which is lost in ESCO1. Depletion of either CRL4s or ESCO2 causes a defect in SMC3 acetylation, which can be rescued by HDAC8 inhibition. More importantly, both CRL4s and PCNA act as mediators for efficiently stabilizing ESCO2 on chromatin and catalyzing SMC3 acetylation. Taken together, we propose an evolutionarily conserved mechanism in which CRL4s and PCNA promote ESCO2-dependent establishment of sister chromatid cohesion.