cssi/SciSciGPT-SciSciNet huggingface dataset:
Prediction of Wing Structural Mass for Transport Category Aircraft Conceptual Design

This paper describes the development of statistical semi-empirical relationships to help estimate the structural weight of wings, applicable to conventionally configured transport category aircraft design. These models are based upon a wing primary structure weight derived from an optimizing beam-element formulation. The underlying beam-element method sizes primary structure based upon “envelope” inertial and aerodynamic loads arising from maneuvering flight and hard-landing conditions. It sizes structure cognizant of tensile yield, compression yield, compression buckling of the skins and compression buckling limitations of integrally stiffened wing covers. Because our primary structural weights are based upon physical geometry we capture “real world” design effects that escape lower order physics based and purely empirical methods. Our trends differ substantially on many accounts from those “famous” wing weight regressions based upon simple strength concerns.
Suggestions on the Development of Heavy Energy Consumption Industry in Gansu

On the basis of the status quo and problems of heavy energy consumption industry,this paper analyzes the main causes for the problems that influence the development of high energy consumption industry in Gansu province,such as the high electric power consumption,low industrial concentration and slow business transformation.Through an analysis of the advantages of high energy consumption industry in Gansu,the paper puts forward some suggestions on the development of heavy energy consumption industry,which may provide a guideline for solving the problems encountered by such industry.
Rapid determination of 3-monochloropropane-1,2-diol in soy sauce by using gas chromatography-mass spectrometry

Objective:To establish a method for rapid determination of 3-monochloropropane-1,2-diol(3-MCPD) in soy sauce by gas chromatograph-mass spectrometry(GC-MS).Methods:D5-3-MCPD was used as the deuterium isotope internal standard.The samples were cleaned up with n-hexane,then extracted by ethyl ether.The target compound was derivatized by heptafluor-oheptabutyric acid anhydride amended with triethylamine(HFBA-Et3N) and determination was performed by gas chromatograph-mass spectrometry at selective ions monitoring(SIM) mode.Results:The detection limit was 0.005 mg/kg,the recoveries were 96.0% and 104.0%(n=6) for the soy sauces spiked at two different levels,RSD10%,and a good linear relationship(r=0.9993) was obtained over the concentration range of 0.010 ng～0.600 ng.Conclusion:This method is accurate,rapid,economical,environmentally beneficial and suitable for routine determination of 3-MCPD in soy sauce.
Abstract B53: Determinants of serum 25-hydroxyvitamin D levels in African American women in the AMBER Consortium

Background: African Americans (AAs) are known to have a higher prevalence of vitamin D deficiency than European Americans (EAs). Aside from darker skin pigmentation being a major contributing factor, few studies have investigated determinants of blood levels of 25-hydroxyvitamin D (25OHD) in AA women. Recent evidence suggests that differences in levels between AAs and EAs were largely eliminated after accounting for levels of vitamin D binding protein (VDBP). In the current study, we conducted a comprehensive investigation of associations between genetic and non-genetic factors, including circulating VDBP levels, and serum 25OHD levels in AA and EA women. Study population and methods. Data and biospecimens were examined in the context of the African American Breast Cancer Risk and Epidemiology (AMBER) consortium. For this analysis, levels were measured in 1,756 healthy controls from two case-control studies in AMBER, the Carolina Breast Cancer Study (CBCS) and the Women9s Circle of Health Study (WCHS), and included 909 AA and 847 EA women. Blood samples collected at the time of enrollment were used for 25OHD measurement by DiaSorin Liasion immunochemiluminometric assay and VDBP measurement by Assaypro Gc-Globulin ELISA assays. Epidemiological data were collected from questionnaires and harmonized across studies. Genotype data for 25,248 typed and imputed germline variants in vitamin D-related pathways were available as a part of exome genotyping array from AAs in the consortium. Percent of European ancestry in AAs was estimated based on genotype data of ancestry informative markers. Univariate analyses and generalized linear regression analyses were conducted to relate serum 25OHD levels with genetic and non-genetic factors and between AA and EA women. Results: AA women had markedly lower 25OHD levels than EA women (14.2 ng/ml vs. 21.1 ng/ml, p Conclusion: VDBP levels had little impact on notable differences in blood 25OHD levels between AAs and EAs. In addition to race, obesity, season of assessment, and several lifestyle factors were also important determinants of 25OHD levels. Genetic determinants of 25OHD levels in AAs are likely different from those in EAs, which warrants further investigation. Citation Format: Song Yao, Chi-Chen Hong, Ting-Yuan David Cheng, Gary Zirpoli, Stephen A. Haddad, Katherine L. Lunetta, Elisa V. Bandera, Andrew F. Olshan, Julie R. Palmer, Christine B. Ambrosone. Determinants of serum 25-hydroxyvitamin D levels in African American women in the AMBER Consortium. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr B53.
Cutaneous Ureteroileostomy in the Spinal Cord Injured Patient: A 15-Year Experience

A review is presented of 39 patients with spinal cord injury who were diverted by ureteroileostomy. Because of a significant complication rate and the fact that some normal renal units may deteriorate, the procedure is reserved for the patient with irreversible upper tract changes that fail to respond to more conservative management.
Computerized tomography demonstration of an intrarenal teratoma.

AbstractThe computerized tomographic appearance of an intrarenal teratoma is described. The differential diagnoses, especially from Wilms tumor, are discussed.
Elementary Teachers' Perceptions of Technology Proficiencies and Motivation to Integrate Technology in School Curricula

Despite the availability of technological resources, the number of teachers integrating and using technology innovatively in the classroom is unknown. This investigation explored teachers' perceptions of proficiency in the use of computer technology in the classroom. Self-determination theory assisted the examination of motivation as decisions are made to integrate technology into the classroom curriculum. A qualitative, multiple case study design was used to explore the views of 10 technology-using elementary teachers in the use of technology in the classroom. Using the constant comparative method, the results showed that teachers were found to be efficacious when incorporating technology into the curriculum and believed their actions could produce the desired results despite their technological skill level. Teachers were found to be self-determined and motivated to integrate technology; however, innovative practice was not evident while existing practice conformed to the instructional norms of the school. Recommendations for teacher professional development are included in this study.
Money Market Funds and Regulation

This article examines money market funds and the regulation that was promulgated in the wake of the Lehman Brothers bankruptcy during the financial crisis of 2007 and 2008. Various explanations for the ensuing run-like behavior are discussed, including a first-mover advantage related to potential fire sales, the ability to redeem shares at a stable $1.00 when funds are valued below $1.00, and flights to quality and transparency. We then discuss regulatory reform, beginning with the SEC's 2010 amendments and concluding with its 2014 Money Market Fund Reform rules, which require (a) all funds to implement liquidity fees and redemption gates and (b) institutional prime funds to price at their floating net asset value. The economic underpinnings of the SEC's final policy choices are discussed and compared to alternatives, such as capital buffers, that were considered but not adopted.
Isolation, Properties, and Structure of Human IgA Myeloma Globulins

For the past few years our work has been based on the principle that the characteristic covalent structure of 99% of all human immunoglobulins could be established by determining the amino acid sequence of five kinds of polypeptide chains: κ and λ light chains, and γ, μ, and a heavy chains. We reported the first complete sequence of κ (1) and λ (2,3) light chains. Others sequenced the γ chain (4,5) and we recently reported the complete sequence of the μ chain (6). The a chain is the last of the big five, and many laboratories are now engaged in its study.
Why proteomics is not the new genomics and the future of mass spectrometry in cell biology.

Mass spectrometry (MS) is an essential part of the cell biologist’s proteomics toolkit, allowing analyses at molecular and system-wide scales. However, proteomics still lag behind genomics in popularity and ease of use. We discuss key differences between MS-based -omics and other booming -omics technologies and highlight what we view as the future of MS and its role in our increasingly deep understanding of cell biology.
Motion control of a robotic device for passive rehabilitation of human shoulder and elbow joint movement

Stroke is one of the main cause of upper limb dysfunction. The number of individuals who lost upper limb function due to stroke is increasing day by day and is projected to continue increasing at an alarming rate in United States. Repetitive movement therapy has been the main method to regain lost mobility. We have designed 3 degrees of freedom (DOF) wearable robotic assistive device to provide passive rehabilitation for shoulder (abduction-adduction and vertical flexion-extension) and elbow (flexion-extension) to those patients. A nonlinear computed torque control technique is used for dynamic simulation of the robot. Simulated results show that the controller can effectively maneuver the robot to follow the reference trajectories (passive rehabilitation exercises). To simulate the spasticity and to check the robustness of the controller disturbances were added in each joints and tracking performance of the controller was further evaluated. Excellent tracking performance of the controller was observed in this case as well with error in tracking less than 0.05°.
Systems thinking and predictive analytics to improve veteran healthcare scheduling

As a culture, the United States acknowledges that the delivery of veteran services to those who risked their lives and suffered to protect our nation is a top national priority. Over the past several years, however, the media have reported stark examples of how these services are lacking, particularly in the case of medical appointment scheduling. At the same time, the Veterans Health Administration is plagued by strikingly high no-show rates at its medical outpatient clinics and a resulting handicap in resource allocation. We bring to bear systems thinking to address these issues. As a result, we developed a model for a dynamic overbooking system that receives the probability of a patient arriving on-time for their appointment from the patient's phone and couples this real-time probability with prior probability derived from existing VA data. Note that the system protects patient privacy by never transmitting nor sharing location data. When the arrival probability of a patient falls below a given threshold, an algorithm can automatically cancel a patient's appointment and re-assign it to another patient drawn from a pool of wait-list and other patients with high arrival probabilities given their current location. In this presentation, we share the progress to date on our approach, and our proposals for future work and implementation.
THE DIRICHLET-TYPE 1 INTEGRAL AND ITS APPLICATIONS TO MULTINOMIAL-RELATED PROBLEMS

Publisher Summary This chapter presents a wide variety of problems in which it would be useful to apply tables of the incomplete Dirichlet integral. It discusses Dirichlet-type 1 integral and its applications to multinomial-related problems. The differences of the tabled values can be used to evaluate higher derivatives and, thus, write down a Taylor expansion quite easily. Applications of Dirichlet-type 1 are related to combinatorics and/or number theory, to multinomial probabilities, to problems of ranking and selection, and to Dirichlet-Type 2 Evaluation problems. The chapter presents a problem to highlight an unusual tie-in between combinatorics, probability, and the Dirichlet-type I.
What Is Clickbait? (Check All that Apply)

This chapter argues that clickbait, like so many examples of copious exchange, has roots in the early modern period. When clickbait is discussed in twenty-first-century terms, it is usually as a trick or trap, an undignified, undignifiable distraction. In Renaissance literature, characters can indeed be said to take the clickbait when they find themselves baited into acts of indignity; but in the process they find ways to articulate—eloquently and copiously—a conclusion simultaneously lofty and deflating: all human acts are acts of indignity. To arrive at what this chapter introduces as the clickbait ethos is to arrive at this place of paradox; it is to take a leap—intellectual, romantic, spiritual, what you will—that is also a pratfall. It is to react to the mundane or inane as if it is complex, secret, even miraculous. It is to adopt the tagline of a clickbait-generating twenty-first-century website: all content deserves to go viral.
Response Assessment in Neuro-oncology (RANO): An Update

Abstract Malignant brain tumors continue to pose a significant clinical challenge with few effective treatment options. In an effort to foster progress, an international working group was formed to address endpoint assessment in neuro-oncology. This group proposed a set of criteria, which are now termed the Response Assessment in Neuro-Oncology (RANO) criteria. The aim of this working committee is to create standardized guidelines to be able to assess clinical or imaging response following treatment in patients with a variety of brain tumors, which can be applied in future clinical trials. Since the publication of first guidelines in 2010, these criteria have been widely accepted in a variety of clinical trials worldwide. The data generated using these standardized guidelines can be pooled and analyzed in a robust manner to accept or refute a particular treatment modality. The aim of this review is to summarize the current RANO guidelines and recommendations in patients with low-grade glioma, high-grade glioma, brain metastasis, and leptomeningeal metastasis. We have also touched upon the key clinical and imaging criterion used for RANO evaluation as well as role of newer imaging and biomarkers. We have also included the role of extended RANO committees, which are working in close collaboration.
Recognizing Textual Entailment at RTE4 with CERES

This paper reports on the performance of a new system for recognizing textual entailment. We present a brief overview of the CERES system and summarize its semantic alignment method for determining entailment. Then, we describe the experiments that were performed, both official and subsequently, against the RTE4 test dataset. We also report on comparison runs against the previous RTE3 development and test datasets.
Genetics and Properties of Cellulases

Cellulases are enzymes which degrade the insoluble, abundant polymer cellulose. In order to perform this task bacteria, fungi, plants and insects have developed a variety of different systems with multiple cellulases. In this review the similarities and differences of these enzymes are summarized based on the burgeoning information gained in recent years from amino acid sequences, three dimensional structures and biochemical experiments. The independent cellulases of aerobic organisms are contrasted with the cellulosomes of anaerobic organisms. The ability of different enzymes to synergize with each other is discussed along with the role of the different types of enzymes in cellulose degradation.
Basics of Test and Role of HDLs

As the first chapter of a book on digital system test, this chapter tries to cover some of the basics. Also, as the first chapter of a book that emphasizes the use of HDLs in test, we try to cover HDL-based design flow and discuss how various test applications fit in this process, and we show various places where HDLs can help the test process of digital systems. In this chapter we try to answer some of the important questions about digital system testing. The primary questions that need to be answered are what it is that we are testing in digital system test, and why we are testing it. The answer to these questions are: A manufactured chip or device, which will be elaborated in the sections that follows, and we are testing the device for physical defects. Other questions that remain to be answered are regarding the methods that we use for testing, ways of making a chip or a manufactured device more testable, how HDLs can help the test process, and finally what constraints we have in digital system testing.
Passive Electrotonic Structure and Dendritic Properties of Hippocampal Neurons

Most central nervous system (CNS) neurons possess a considerable spatial dispersion of structures specialized for postsynaptic reception. Variability in dendritic structure, as well as differing distributions of spines (Scheibel and Scheibel, 1968) and other synaptic specializations, confer unique capabilities on each cell type. Neurons in the hippocampus demonstrate a complexity of neuronal shape (Figure 1), and dispersion of spine synapses that are typical particularly of cortical tissue (Minkwitz, 1976; Wenzel et al., 1981). The various classes of hippocampal neurons also possess a distribution of nonsynaptic ionic conductances that can modify signal transfer from input sites to the summation or recording site (Jack et al., 1975; Rall, 1977), and thus complicate the interpretation of synaptic inputs. Such signal modification may occur according to both passive cable attenuation and nonlinear forms of distortion, neither of which are usually subject to intuition. Quantitative models of neurons have been developed both to enhance our ability to extrapolate from a recorded signal back to the original synaptic signal, and also to help us understand the signal’s importance and role in the process of neuronal integration. Complex processing and multiple interactions can be approached in a model in a way that cannot be done experimentally.
Revisiting Successful Aging With HIV Through a Revised Biopsychosocial Model: An Update of the Literature

The concept of successful aging was recognized only recently by HIV researchers because people living with HIV (PLWH) in the early epidemic were not expected to survive. With the introduction of antiretrovirals that block viral replication, PLWH are now aging with HIV. Given the complex nature of HIV within the social, economic, and political climates in which it occurs, a holistic model of successful aging is needed to guide researchers and clinicians. Several overarching models exist, but must be updated for rapidly advancing HIV and aging research agendas. We provide an updated, adapted, and integrated biopsychosocial model of successful aging with HIV based on the principles of Baltes and Baltes (1998) on 8 essential components of successful aging: (a) length of life, (b) biological health, (c) mental health, (d) cognitive efficiency, (e) social competence, (f) productivity, (g) personal control, and (h) life satisfaction. Clinical practice and research implications are highlighted.
Hamlet and the Kairos

To fulfill the ghost's injunction that he seek out his father's killer, Hamlet must learn not to expect that the opportune moment for revenge will be determined by himself within the daily sequence...
Hawaiian word phonetic generator

Hawaiian words can be intimidating to attempt to pronounce. Words like humuhumunukunukuapua'a look like someone may have fallen asleep on the keyboard. The language is actually very simple and only contains 12 characters; 5 vowels and 7 consonants. This assignment has the students taking a string of a Hawaiian word and outputting the phonetic version.
Cooperative cities: Municipal support for worker cooperatives in the United States

ABSTRACTThis article examines the emergence of cooperative cities, or municipalities creating enabling environments for worker-owned cooperatives since 2009 by adopting legislation and budget initi...
Nicotine Addiction and Alpha4beta2* Nicotinic Acetylcholine Receptors

Abstract The reinforcing effects of nicotine are mediated primarily by the activation of nicotinic acetylcholine receptors (nAChRs) in the brain. Specifically, a large literature clearly indicates that α4β2-containing nAChRs expressed in the mesolimbic dopamine pathway play a critical role in nicotine-addiction-like behaviors in animal models. Based on these preclinical studies, α4β2-containing nAChRs have been identified as key molecular targets for development of novel smoking cessation medications. Indeed, varenicline was rationally designed as a smoking cessation aid based on its action as a partial agonist at α4β2-containing nAChRs. The aim of this chapter is to review the role of α4β2-containing nAChRs in nicotine addiction and discuss promising new α4β2 nAChR-focused pharmacological strategies for smoking cessation.
Pediatric Electronic Health Records and Research

Pediatric providers use electronic health record systems to review patient information, to document care, to order clinical interventions, and to perform related administrative tasks. All of these activities create data that might be useful in research, although research is seldom the objective of EHR-related data entry. Providers may use other information systems (e.g., specialized systems for analyzing electrocardiograms), but the EHR is the central application for clinical and administrative clinical activities. While there are a few EHR systems designed specifically for care of pediatric patients, most pediatric providers adopt general-purpose EHRs that must be customized for specialized pediatric environments. In this chapter we outline the special functional requirements of EHRs (e.g., growth monitoring, medication dosing, and immunization management), the relative difficulty of meeting these requirements with EHRs that are currently available in the marketplace, and current adoption trends. We discuss workflows that present special challenges to EHR implementation. We discuss the typical workflow phenomena that affect the use of data for research and other secondary uses. We also discuss special aspects of terminology systems employed by EHRs that have implications for pediatric usability. Lastly, we address special issues in the use of EHR data for the extraction of care quality measures.
Complications of liver transplant

Liver transplantation has become a definitive treatment for patients with end-stage liver disease and those meeting Milan criteria for hepatocellular carcinoma. The morbidity and mortality associated with liver transplantation continues to decrease thanks to refinements in surgical technique, immunosuppression, and imaging. In particular, imaging plays a vital role by facilitating early detection of post-operative complications and enabling prompt treatment. Post-operative complications that lead to graft failure and patient morbidity/mortality can be generally categorized as vascular, biliary, parenchymal, and malignant. Vascular complications include stenosis and thrombosis of the hepatic artery, portal vein, and inferior vena cava; hepatic artery pseudoaneurysm; arteriovenous fistula; and celiac stenosis. Biliary abnormalities include strictures, bile leak, obstruction, recurrent disease, and infection. While imaging is not primarily utilized to diagnose allograft rejection, it plays an important role in excluding mechanical causes of graft dysfunction that can mimic rejection. Ultrasound is routinely performed as the first-line imaging evaluation for the detection and follow-up of early and delayed complications. Cholangiography and magnetic resonance cholangiopancreatography are useful in detecting and characterizing biliary complications. Computed tomography is often used to further evaluate abnormal findings on ultrasound or for the characterization of post-operative fluid collections. The aim of this review is to discuss and illustrate the imaging findings of complications associated with liver transplantation and their role in facilitating treatment.
A Smartphone-based Network Architecture for Post-disaster Operations Using WiFi Tethering

Electronic communication is crucial for monitoring the rescue-relief operations and providing assistance to the affected people during and after disasters. Given the ubiquity of smartphones, we envision that smartphones with lost connection (due to damage) to the communications infrastructure are nevertheless integrated seamlessly into the network as far as possible. To achieve this, we propose to build ad hoc subnetworks of disconnected smartphones using the WiFi tethering technology and ultimately connect them to either the emergency communication equipment deployed in the disaster area or to other smartphones that have still the network connectivity. The proposed architecture for such integration and a defined software-based control through the emergency control center (ECC) enables battery aware collection of critical data through smartphone sensors. The developed solution supports mobility of all smartphones, including those that have lost direct cellular connectivity as well as those that have not and are willing to act as gateways. We demonstrate how the proposed scheme can be tied to the standardized wireless emergency alert service and how it can effectively handle mobility tolerant device discovery and data transfer.
Robust Moving Target Detection for Distributed MIMO Radar in Non-Homogeneous Clutter

In this paper, we consider the problem of moving target detection (MTD) in distributed multiple-input multiple- output (MIMO) radar in non-homogeneous environments with robustness against clutter mismatch. The non-homogeneous clutter is modeled in the Doppler domian as a linear combination of multiple discrete scatterers whose Doppler frequencies and powers vary from range bin to another and from transmit- receive pair to another. We develop a new method for MTD with robustness against mismatch between the actual and presumed discrete clutter Doppler frequencies. The proposed method first obtains an accurate estimate of the non-homogeneous clutter Doppler frequencies for every transmit-receive pair in the system using computationally-efficient fast Fourier transform (FFT)- based techniques. Then, the method mitigates the heterogeneous clutter by projecting the received data onto the orthogonal subspace of the discrete clutter, followed by the application of generalized-likelihood ratio test (GLRT) detection. Simulation examples are provided to demonstrate the robustness of the proposed GLRT over existing techniques.
Trastuzumab-induced cardiotoxicity and hypertension among racially and ethnically diverse patients with HER2-positive early-stage breast cancer.

e24092Background: Trastuzumab improves breast cancer survival but is associated with an increased risk of heart failure. Identifying risk factors associated with trastuzumab induced cardiotoxicity ...
The interactions of diet-induced obesity and organophosphate flame retardant exposure on energy homeostasis in adult male and female mice

Previously, sex-dependent alterations in energy homeostasis were reported in adult mice fed a standard chow attributed to exposure to a mixture of organophosphate flame retardants (OPFRs) via estro...
Oronasal Fistula Incidence Associated With Vomer Flap Repair of Cleft Palate: A Systematic Review and Meta-Analysis.

Objectives:To determine the incidence of oronasal fistulas (ONF) associated with primary repair of the anterior palate using a single-layered, superiorly based, vomer mucoperiosteal flap.Design:A s...
Assessing the Renaissance of Individuals in International Relations Theory

The study of microfoundations, especially individuals, is enjoying a renaissance in international relations (IR) scholarship. Yet, this rise is more difficult to find in publication data. Using the Teaching, Research, and International Policy (TRIP) journal-article database, we show that only 13.7% of IR articles in 12 leading journals use the first image. This proportion remains approximately the same from 1980 through 2018. Interrogating the data, we show that this distribution does not stem from epistemological or methodological commitments, such as positivism, quantitative analysis, or formal modeling. We suggest several reasons for this apparent disjuncture between qualitative assessments of the rebirth of first-image theorizing and the quantitative data that imply a slower or perhaps more limited return.
Surgical management of a rare myxopapillary ependymoma of the gluteal region: A case report

Background Ependymomas are rare tumors originating from neuroepithelial cells lining the wall of the ventricles or central canal of the spinal cord. While these tumors mainly occur within the central nervous system (CNS), there are occasional reports in children and young adult patients with a primary tumor occurrence outside of the CNS. Ependymomas of the sacrococcygeal region have been infrequently described in the literature with no standard of care established. We present a case report and review of the literature regarding this rare entity. Case description A 24-year-old woman presented with right gluteal pain worsened by sitting and a palpable soft tissue mass of the sacrococcygeal region. Magnetic resonance imaging revealed a 3.7 cm cystic mass centered in the right gluteal region. She underwent a biopsy at an outside institution, with histology revealing myxopapillary ependymoma. The patient was referred to our hospital and underwent an interdisciplinary neurosurgical and orthopedic oncology en bloc resection of the ependymoma, which intraoperatively appeared to originate from the coccygeal nerve. Conclusion In the present report, the authors demonstrate that a myxopapillary ependymoma may present as an isolated gluteal mass attached to the coccygeal nerve, without frank CNS involvement. Furthermore, an interdisciplinary approach to surgical resection of this lesion appears to represent an effective treatment modality.
Abstract #2984: Benzyl isothiocyanate induces heat shock protein 70 expression and inhibits NF-\#954;B activation in human pancreatic cancer cells

We have previously demonstrated that benzyl isothiocyanate (BITC) significantly reduces the survival of human pancreatic cancer cells by inducing cell cycle arrest and apoptosis without having any effect on normal pancreatic cells. In the present study, we found that BITC treatment for 24h caused significant decrease in the transcriptional activity of NF-\#954;B/p65 in Capan-2 human pancreatic cancer cells. Further, BITC treatment also decreased the phosphorylation of NF-\#954;B/p65 at Ser 536 as well as its DNA binding activity in the nuclear fraction of the cells. Current studies also reveal that treatment of Capan-2 cells with BITC significantly induced heat shock protein (Hsp70) expression. Heat shock proteins (Hsp\#8217;s) have been shown to be regulated by variety of stresses including chemical, UV radiation, ischemia, and free radicals. Our results nonetheless indicate the generation of ROS by BITC treatment. The kinetics of Hsp70 induction by BITC treatment correlated with the decreased nuclear translocation of NF-\#954;B/p65. For example, induction in Hsp70 expression appears to be associated with decreased nuclear translocation of NF-\#954;B/p65, 8h after BITC treatment. Co-immunoprecipitation studies revealed about 4 fold increased association of NF-\#954;B/p65 with Hsp70 in Capan-2 cells treated with 10 µM BITC for 24h. In addition, BITC treatment also caused concentration and time dependent decrease in histone deacetylase 3 (HDAC3) expression in Capan-2 cells. HDACs are known to play role in the regulation of NF-\#954;B/p65. Decrease in HDAC3 expression and increase in Hsp70 expression by BITC may be attributed to the inactivation of NF-\#954;B thus implicating multi-level regulation of NF-\#954;B in Capan-2 cells. Further studies on silencing of Hsp70 expression using SiRNA are in progress to delineate the molecular mechanisms of BITC [Supported in part by RO1 grant CA106953 (to S.K.S.) awarded by National Cancer Institute]. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2984.
Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway.

Abstract Little is known about the relationship between stimulation of lacrimal gland (LG) tear protein secretion by parasympathetic versus sympathetic nerves, particularly whether the spectrum of tear proteins evoked through each innervation pathway varies. We have previously shown that activity and abundance of cathepsin S (CTSS), a cysteine protease, is greatly increased in tears of Sjogren's syndrome (SS) patients and in tears from the male NOD mouse of autoimmune dacryoadenitis that recapitulates SS-associated dry eye disease. Beyond the increased synthesis of CTSS detected in the diseased NOD mouse LG, increased tear CTSS secretion in NOD mouse tears was recently linked to increased exocytosis from a novel endolysosomal secretory pathway. Here, we have compared secretion and trafficking of CTSS in healthy mouse LG acinar cells stimulated with either the parasympathetic acetylcholine receptor agonist, carbachol (CCh), or the sympathetic α1-adrenergic agonist, phenylephrine (PE). In situ secretion studies show that PE significantly increases CTSS activity and protein in tears relative to CCh stimulation by 1.2-fold (***, p = 0.0009) and ∼5-fold (*, p-0.0319), respectively. A similar significant increase in CTSS activity with PE relative to CCh is observed when cultured LGAC are stimulated in vitro. CCh stimulation significantly elevates intracellular [Ca2+], an effect associated with increases in the size of Rab3D-enriched vesicles consistent with compound fusion, and subsequently decreases in their intensity of labeling consistent with their exocytosis. PE stimulation induces a lower [Ca2+] response and has minimal effects on Rab3D-enriched SV diameter or the intensity of Rab3D-enriched SV labeling. LG deficient in Rab3D exhibit a higher sensitivity to PE stimulation, and secrete more CTSS activity. Significant increases in the colocalization of endolysosomal vesicle markers (Lamp1, Lamp2, Rab7) with the subapical actin suggestive of fusion of endolysosomal vesicles at the apical membrane occur both with CCh and PE stimulation, but PE demonstrates increased colocalization. In conclusion, the α1-adrenergic agonist, PE, increases CTSS secretion into tears through a pathway independent of the exocytosis of Rab3D-enriched mature SV, possibly representing an alternative endolysosomal secretory pathway.
The Solemn Moment: Expanding Therapeutic Jurisprudence Throughout Estate Planning

Estate planning involves much more than visiting a lawyer and executing a will. Indeed, contemporary estate planning employs various will substitutes, such as life insurance, revocable trusts, and payable-on-death contracts, to transfer the client’s property upon death. Because estate planning, including the use of will substitutes, requires the client to confront the inevitability of death, it can affect the client’s psychological wellbeing. Recognizing the connection between estate planning and mortality, a handful of scholars have drawn attention to the psychological implications of estate planning, the law of succession, and the probate process. While this prior work sheds important light on the psychological consequences of the law, this scholarship largely overlooks the role that will substitutes play within estate planning. The goal of this essay is therefore to begin the discussion of how therapeutic jurisprudence, which focuses attention on the psychological consequences of the law and seeks to increase its therapeutic potential, can be applied to will substitutes.
Learning User Preferences Without Feedbacks

Recommending relevant data is vital for helping users to navigate through the ocean of data. We developed a service that learns user preferences through natural user interactions, without asking for user feedbacks, so users are not distracted from their regular workflow. Our approach has few parameters and very low time and space complexities, making it suitable for large scale applications. We demonstrate through experiments how it converges to user preferences and adapts to user behavior changes.
Similarities and Dissimilarities in Submicroscopical Morphology of Interneuronal Contact Sites of Presumably Different Functional Character

Publisher Summary This chapter focuses on four types of commonly occurring loci of interneuronal apposition namely: axo-dendritic, axo-somatic, dendro-dendritic, and axo-axonal. It summarizes the characteristics of these four junctional types. A surface increase of the contact area of the elements involved, by some folding or curving process of the membrane-pair involved, can be found with most axo dendritic and with many dendro-dendritic junctions. Synaptic vesicles are associated with all axo-dendritic, axo-somatic and axo-axonal junctions. The subsynaptic organelle is found in most axo-dendritic junctions. Morphological signs of polarity (that is, the existence of a difference in cytoplasmic characteristics on either side of the synaptolemma and/or the attachment to the postsynaptic membrane of the “half-size” interlemmal elements) are observed in axo-dendritic and axo-somatic synapses. Interlemmal elements could be shown to occur with all the types of connections discussed. These elements are encountered in the majority of axo-dendritic and axo-somatic synapses. The fact that, in those cases, the synaptic cleft is seen as a structureless or nearly structureless space of intermediate electron density is in accordance with this view. In dendro-dendritic junctions the interlemmal elements can be seen fairly often. In axo-axonal junctions, they seem to occur only in a minority of instances.
Getting Started in 3D with Maya: Create a Project from Start to Finish―Model, Texture, Rig, Animate, and Render in Maya

Deliver professional-level 3D content in no time with this comprehensive guide to 3D animation with Maya. With over 12 years of training experience, plus several award winning students under his belt, author Adam Watkins is the ideal mentor to get you up to speed with 3D in Maya. Using a structured and pragmatic approach Getting Started in 3D with Maya begins with basic theory of fundamental techniques, then builds on this knowledge using practical examples and projects to put your new skills to the test. Prepared so that you can learn in an organic fashion, each chapter builds on the knowledge gained in the previous chapter, showing you all the essentials of 3D in Maya, from modeling and UV layout, to texture creation, rigging animating and rendering.As you go from project to project you'll develop a strong arsenal of skills that combined will form a complete end to end process to creating complete projects in Maya. The accompanying website provides all the tools you need to develop your skills. Project files to accompany the practical examples used throughout the text, so you can work along with the examples. Additional textures and models will give you all the resources you need to start making your own projects in no time at all. --Provides all you need to get started, including avaluable roadmap to the "big picture" of 3D production. Rather than a lengthy description of dialog boxes or option lists,you gaina fullunderstanding of how Maya "thinks" so thatyou canbecome effective real-world artists. --Watkins has over twelve years of 3D education experience, having trained hundreds of 3D artists. With multiple award winning students, he knows how people learn 3D, what works and what doesn't, proper pacing, and offers engaging,manageable, yet ambitious tasks. --Create a project from start to finish using all the major components of the 3D process- modeling, UV layout, texture creation, rigging, animation, and rendering- with Maya. --Bonus content for professors! Includes suggested curriculum for 3D based trainingfor semester and year-long sessions, suggested layouts and pacing. How do these chapters fit into a teaching strategy? How long should a class spend on each chapter? All these questions are answered in the included Curriculum Appendices and online resources.
Impact of Atomic Physics on Fundamental Constants

This report offers one experimentalist’s outlook on the constants area especially from the perspective of atomic physics. There are many recent reviews of selected areas of such work in addition to the well-known periodic overall studies including least squares adjustments. My intent is neither to offer the scientific depth of the specialized reviews nor to even approach the technical scope of an overall adjustment.
Music, Memory, and Relatedness

This article examines the role of music and musical speech as transitional phenomena, as facilitators of early dyadic and later relationships, as aids to the development of memory, and as assisting in the self-definition of individuals and groups. It draws on literature from psychoanalysis, developmental psychology, and neuroscience, and presents illustrations from individual development as well as cultural phenomena. Copyright © 2013 John Wiley & Sons, Ltd.
Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene.

Human GLUT4 protein expression in muscle and adipose tissues of transgenic mice decreases plasma insulin and glucose levels and improves glucose tolerance compared with nontransgenic controls (Liu, M.-L., Gibbs, E. M., McCoid, S. C., Milici, A. J., Stukenbrok, H. A., McPherson, R. K., Treadway, J. L., and Pessin, J. E. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 11346-11350). We examined the basis of improved glycemic control in hGLUT4 transgenic mice by determining glucose homeostasis and metabolic profiles in vivo. Glucose turnover experiments indicated a 1.4-fold greater systemic glucose clearance in hGLUT4 mice relative to controls (p < 0.05), whereas hepatic glucose production was similar despite 26% lower (p < 0.05) glucose levels. Glucose infusion rate during an euglycemic-hyperinsulinemic clamp was 2-fold greater (p < 0.05) in hGLUT4 mice versus controls, and skeletal muscle and heart glycogen content were increased 3-5-fold (p < 0.05). The increased peripheral glucose clearance in hGLUT4 mice was associated with increased (25-32%) basal and insulin-stimulated glucose transport rate in soleus muscle (p < 0.01), and increased muscle plasma membrane-associated GLUT4 protein. Fed hGLUT4 mice displayed 20-30% lower plasma glucose and insulin levels (p < 0.05) and 43% elevated glucagon levels (p < 0.001) compared with controls. Triglycerides, free fatty acids, and beta-hydroxy-butyrate were elevated 43-63% (p < 0.05) in hGLUT4 mice due to hypoinsulinemia-induced lipolysis. Free fatty acids and beta-hydroxybutyrate levels in hGLUT4 mice increased further upon fasting, and skeletal muscle glycogen levels decreased markedly compared with controls. The data demonstrate that high level expression of hGLUT4 increases systemic glucose clearance and muscle glucose utilization in vivo and also results in marked compensatory lipolysis and muscle glycogenolysis during a fast.
For a Social Psychology of Prayer

Prayer is one of the most common religious activities practiced by Americans. In this review, I make the argument that prayer is a social psychological phenomenon that scholars should treat as such. After a discussion of the use of prayer as a proxy for overall religiosity and a brief excursus on current typologies of prayer, I provide three main arguments for the claim that prayer is a social psychological phenomenon. First, I review evidence that prayer is a legitimate social interaction with “imagined others” that shares many characteristics with and involves the same cognitive and interactional processes as human-human interactions. Second, I review evidence that shows that individuals’ social positions influence the frequency of prayer. Third, I review evidence that prayer influences social action through psychological and interactional processes.
Spine Trauma: Subaxial Cervical Spine (C3–C7)

The subaxial cervical spine (C3–C7) provides the majority of forward and lateral neck flexion and almost 50 % of cervical rotation. Over 75 % of all cervical spine injuries in adults occur in the subaxial region, and C5–C6 is the most frequently injured level. Injuries include fractures, subluxations, dislocations, and ligamentous tears, each of which can be isolated or can occur in conjunction with one another. Suspected cervical spine trauma should be screened with thin-cut axial CT from the occiput to T1 with sagittal and coronal reconstructions. General management involves early cervical immobilization and closed reduction of the injury whenever possible, then operative or nonoperative stabilization. Treatment is based on the mechanism of injury, neurologic deficit, spinal column alignment, type of bony injury, and expected long-term stability. Missing a cervical injury on initial evaluation can result in delayed treatment, instability, and permanent neurologic deficit.
Economy suspended: the possibilities of a Badiouian business ethics.

In the philosophy of Alain Badiou, ethics can only arise in relation to an evental truth procedure that breaks from the economic logic of a situation. Further, because for Badiou there cannot be economic truths per se – rather, economic matters must be understood in their relation to one or more truths in the domain of love, art, science or politics – a Badiouian business ethics would look entirely distinct from any ethics that simply places limits on certain kinds of economic activity. Although Slavoj Žižek, among others, has suggested that this marks an essential weakness in Badiou's economic/political theory, it may actually be the greatest strength of his position. Within a capitalist system, a Badiouian business ethics would then be a question of mobilizing economic resources in order to serve the ongoing construction of a truth procedure. For a business to be considered ethical on Badiou's terms, it must break – and continue to break – from the dominant logic of capitalism and its merely economic pursuit of profit maximization.
How i do it head and neck and plastic surgery a targeted problem and its solution: Endoscopic septoplasty†

Often there is a need to address the status of the nasal septum during functional endonasal sinus surgery. The outcome of a sinus procedure can be enhanced if the surgeon has better exposure of the operative area or if the patient receives a larger nasal airway, which provides laminar air flow. We present a technique of managing septal deviations and obstructions that adds little additional time to the sinus procedure and allows direct evaluation of the septum with the endoscopes. We describe this relatively simple technique, indications for its use, and results of the first 38 cases.
Epimorphisms in certain categories of transducers

In a category-theoretic treatment of automata, one is sometimes lead to consider various transcriptions or transductions of free monoids as a component of the morphisms in the category. It then becomes of interest to determine the epimorphisms in the underlying category of transductions. We study this question in several familiar settings centered around the notion of a gsm mapping.