cssi/SciSciGPT-SciSciNet huggingface dataset:
Tips for Constructing a Promotion and Tenure Dossier that Documents Engaged Scholarship Endeavors

The growth of the community engagement movement in higher education over the past 2 decades has resulted in more faculty member interest and practice in engaged scholarship. As more institutions value this work, faculty members are looking for ways to enhance the effectiveness of their engaged scholarship dossiers for promotion and tenure. This article summarizes con tent from a workshop on strengthening the engaged scholarship dossier offered by the author in a variety of venues. The author provides an overview of the engaged scholarship dossier context, explains why a focus on documenting engaged scholarship is important, outlines four steps for documenting engaged scholarship in the academic dossier, and lists best practices for faculty members building their engaged scholarship dossiers.
Twice Daily Netilmicin Therapy in Paediatric Patients with Systemic Infections

This open investigation evaluated twice daily administration of netilmicin in infants and children with systemic infections. Thirty-four patients aged 2-41 months, were enrolled; 28 and 34 were evaluable for efficacy and safety, respectively. Netilmicin was administered intravenously or intramuscularly every 12 h at a dosage of 2.0-4.4 mg/kg (mean 3.5 mg/kg) for 5-15 days (mean 11 days). Throughout the trial, signs and symptoms of infection were evaluated in conjunction with laboratory data to determine patients' clinical response; specimens from appropriate sites were cultured to determine bacteriological response; and laboratory tests were performed to monitor haematopoietic, hepatic and renal functions. Peak and trough serum netilmicin levels were measured during treatment. Clinical responses included complete resolution in 26/28 (93%) patients, improvement in 1/28 (4%) and failure in 1/28 (4%). Bacteriological responses included elimination of 34/36 (94%) pathogens and persistence of 1/36 (3%); response was indeterminate for 1/36 (3%). Peak serum netilmicin levels of 5.1-14.1 micrograms/ml and trough serum netilmicin values of 0.1-1.5 micrograms/ml remained within acceptable ranges during treatment. No clinically significant changes in haematopoietic, hepatic and renal functions were evident during the trial. Untoward reactions were limited to redness and/or induration at the administration site in 4/34 (12%) patients.
Automated Adaptation of Component Interfaces with Type Based Adaptation

The construction of software can be improved by building software from reusable parts, which are typically referred to as software components. Software components can be developed independently from each other, thus decreasing the overall development time of a project. A disadvantage of software components, however, is that due to their independent development, component interfaces do not necessarily match and thus need to be adapted. In this paper, we present type based adaptation an adaptation technique that, unlike other techniques, supports the automated adaptation of component interfaces by relying on the component’s type information and without requiring knowledge about the component’s implementation. In this paper, we describe how we have achieved this kind of functionality and we will show how we have applied type based adaptation in practice.
Toward Brighter Hybrid Magnetic-Luminescent Nanoparticles: Luminosity Dependence on the Excited State Properties of Embedded Dyes

A series of hybrid, magnetic, and luminescent silica nanoparticles (SNP) have been synthesized and their photophysical properties characterized. The nanoparticles contain, on average, one iron oxide nanoparticle as a magnetic core. The embedded dyes include fluorescein, Alexa Fluor 546, tetramethylrhodamine (TMR), and 4,4-difluoro-5-(2-pyrrolyl)-4-bora-3a,4a-diaza-s-indacene (Bodipy), which are known to have a singlet excited state, and 5-(dimethylamino)naphthalene-1-sulfonyl (dansyl), 7-(diethylamino)coumarin-3-carboxy (coumarin), and tris(bipyridine)ruthenium(II) dichloride (Rubipy) derivatives, which have a charge transfer excited state. In general, the photophysical properties of the magnetic-core dye-doped silica nanoparticles, SNPdye, where dye is one of the seven dyes studied in this project, are dictated by homogeneous energy transfer between dye molecules and by dye aggregation. Molecules with a small Stokes shift and affinity for aggregation upon silica encapsulation (TMR and Bodipy derivatives)...
Control of Olefin Hydroarylation Catalysis via a Sterically and Electronically Flexible Platinum(II) Catalyst Scaffold

PtII complexes supported by dipyridyl ligands have been demonstrated to catalyze olefin hydroarylation. Herein, studies on the influence of dipyridyl motif variation are reported. Increasing the chelate ring size of dipyridyl-ligated PtII complexes from five- to six-membered rings by replacing 4,4′-di-tert-butyl-2,2′-bipyridine with 2,2′-dipyridylmethane has been shown to increase catalytic activity and longevity for catalytic ethylene hydrophenylation. For 2,2′-dipyridyl ligands, the presence of methyl groups in the 6/6′-positions of the pyridyl rings reduces the extent of dialkylation to produce diethylbenzenes but also increases the rate of catalyst decomposition. Substituting the methylene spacer between the pyridyl rings of 2,2′-dipyridylmethane with more electron-withdrawing groups also reduces catalytic efficiency. The steric profile of PtII complexes with increased chelate ring size or substituents in the 6/6′-positions of the pyridyl rings provides a marked change in regioselectivity for ethylene...
Antithrombic activity of chicken plasma induced by estrogenic substances.

SummaryThe plasma of laying hens exhibits an inhibitory effect on the interaction of thrombin and fibrinogen. Similar inhibitory activity can be induced in the plasma of chickens of any age and of either sex by the administration of synthetic estrogenic compounds. This effect can be prevented by agents which interfere with normal metabolism of the estrogenic material in the experimental animal. The observed effect is similar to that produced by heparin, but plasma assays have been negative for heparin, and the substance responsible for the heparin-like activity has not been isolated or identified.
Intercalation Pseudocapacitance of Exfoliated Molybdenum Disulfide for Ultrafast Energy Storage

We report intercalation pseudocapacitance of 250 F g−1 for exfoliated molybdenum disulfide (MoS2) in non-aqueous electrolytes that contain lithium ions. The exfoliated MoS2 shows surface-limited reaction kinetics with high rate capability up to 3 min of charge or discharge. The intercalation pseudocapacitance originates from the extremely fast kinetics due to the enhanced ionic and electronic transport enabled by the slightly expanded layer structure as well as the metallic 1T-phase. The exfoliated MoS2 could be also used in a Li-Mg-ion hybrid capacitor, which shows full cell specific capacitance of 240 F g−1.
Nickel-Catalyzed Proton-Deuterium Exchange (HDX) Procedures for Glycosidic Linkage Analysis of Complex Carbohydrates.

The structural analysis of complex carbohydrates typically requires the assignment of three parameters: monosaccharide composition, the position of glycosidic linkages between monosaccharides, and the position and nature of noncarbohydrate substituents. The glycosidic linkage positions are often determined by permethylation analysis, but this can be complicated by high viscosity or poor solubility, resulting in under-methylation. This is a drawback because an under-methylated position may be misinterpreted as the erroneous site of a linkage or substituent. Here, we describe an alternative approach to linkage analysis that makes use of a nonreversible deuterium exchange of C–H protons on the carbohydrate backbone. The exchange reaction is conducted in deuterated water catalyzed by Raney nickel, and results in the selective exchange of C–H protons adjacent to free hydroxyl groups. Hence, the position of the residual C–H protons is indicative of the position of glycosidic linkages or other substituents and c...
Socio-demographic differences in risk information seeking sources for non-steroidal anti-inflammatory drugs (NSAIDS)

Abstract Objectives Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for musculoskeletal pain and inflammatory conditions. A better understanding of patient information seeking behavior can help bridge the gap between patient knowledge and health care resources. This study examines the primary sources of NSAID risk information and the associations with patient socio-demographic factors. Methods A cross-sectional survey analysis of patients on prescription NSAIDs (n = 220) seen by primary care physicians in Alabama. Bivariate and multivariable, multinomial logistic regression analyses were conducted to evaluate the associations among primary NSAID risk information sources used with patient socio-demographic factors. Results The primary patient source of information on NSAID risks was physician (57.3%), followed by internet (16.8%), pharmacist (16.4%), and other sources, such as nurses and family/friends (9.6%). Compared to people who use the internet as a primary source of NSAID risk information, patients who were Black/African-American (p = 0.002) and 65 years of age or older (p = 0.009) were more likely to use a physician. Older patients were also more likely to use a pharmacist (p = 0.008) than the internet. In contrast, females (p = 0.032) were less likely to use the pharmacist compared to the internet (p = 0.032). Conclusions Patients obtain information from a variety of sources, but primarily from health care providers. While the internet is a fast growing source of health information, socio-demographic disparities in internet use for seeking information exist. Health care providers should be aware of their patient preferences for information sources on medication risks to meet the age, race, and gender need differences of all patients.
Effects of self-congruity and destination image on destination loyalty: the role of cultural differences

AbstractDestination branding is a key factor in the creation of a differentiated identity to increase a tourist’s interest in travelling to a specific area. This study investigated the effects of self-congruity and destination image on destination loyalty. The sample comprised of both Western and Asian destination tourists to South Korea. To analyse the data, descriptive statistics, confirmatory factor analysis, and structural equation modelling (SEM) methods were utilized. The findings confirmed the influential role of self-congruity and destination image on destination loyalty in both samples. A multi-group SEM analysis revealed the differential effect of self-congruity and destination image on destination loyalty, which was dependent on the tourists’ countries of origin.
Comovement, financial reporting complexity, and information markets: Evidence from the effect of changes in 10-Q lengths on internet search volumes and peer correlations

Abstract We investigate the effect of financial reporting complexity on stock comovement. We hypothesize that investors deal with complexity increases by acquiring low cost information. This information is typically informative not just about the firm of interest but also about other firms with similar fundamentals, which generates excess comovement. We find that increases in 10-Q word counts, a complexity proxy, are consistently followed by increases in 1) internet searches about the firm and 2) R 2 s from regressions between the firm’s returns and its peers’. On a large scale, complexity-induced comovement might hinder investors’ ability to discriminate across stocks and identify business innovators.
Intercultural Comfort through Social Practices: Exploring Conditions for Cultural Learning

High quality cross-ethnic interactions contribute to college students’ development, but knowledge is scant concerning campus settings and conditions that promote these interactions. This study indicates that distinct social practices in particular settings create such conditions. Phenomenological analysis of current and past members of a voluntary community service association (VCSA, a pseudonym), appropriated to meet their social needs, revealed practices leading students from differing ethnic backgrounds to challenge stereotypes and engage in cultural learning. Inductively-derived findings led to a transdisciplinary analysis that synthesizes concepts from institutional (higher education), organizational (voluntary service organization), interpersonal (social ties), and individual (personal development) levels. The emergent concept of intercultural comfort differentiated between meaningful diversity interactions within the student association and apprehensive ones elsewhere. Members experienced this intercultural comfort and an ethnically inclusive moral order due to mission-driven practices emphasizing shared purpose, fellowship, and structured interactions.
Optimizing Plant Health and Pest Management of Lagerstroemia spp. in Commercial Production and Landscape Situations in the Southeastern United States: A Review

Lagerstroemia is a genus of plants comprised of deciduous shrubs or small trees native to China southward into Southeast Asia. L. indica, the oldest and most widespread species in cultivation in the United States, has been cultivated as an ornamental for centuries and was introduced to the Southeastern U.S. over 175 years ago. Much has been disseminated on the culture and commercial production of crapemyrtle species and cultivars; including plant forms and function, adaptability to macro and micro environment, growth and floral characteristics, and commercial production and landscape culture and maintenance. Since the introduction of L. indica in the United States, L. fauriei, L. subcostata and L. limii have also been introduced. However, since the mid 1970s, interspecific hybrids between L. indica × L. fauriei comprise the majority of new cultivar introductions. Breeding efforts have resulted in 133 commercially available cultivars as of December 2011 that include cultivars with ever improving form and f...
The current-mode muddle

Abstract With the arrival of monolithic processes for the fabrication of bipolar transistors during the mid-1960s, it seemed like a good time to examine new paradigms for design. Current-mode (CM) was attractive because it suggested that small voltages swings could be used to process analog signals represented as currents; whatever voltages that did arise were treated as incidental. These were good ideas at the time. Are they still true today? It is important to know when CM offers a real advantage, to know when it is truly valuable, and to know when it is of only passing and academic interest.
A Comparison of the Cognitive Restructuring Psychotherapy Paradigm and Several Spiritual Approaches to Mental Health

The present article suggests that a parallel exists between the cognitive restructuring paradigm of cognitive therapy and some evangelical and charismatic approaches to counseling. A brief examinat...
Situating a Critical Review of Impact Evaluations Within the Political Economy of Global Education Reform: Definition and Method

This chapter addresses issues of definition and method. The first section takes on the challenge of defining what it means to conduct a critical review of impact evaluations within the political economy of global education reform. As discussed, one must go beyond a critical evaluation of the findings of impact evaluations and beyond a critical appraisal of the production of impact evaluations to also consider the role that impact evaluations play, once produced, in the field of global education policy. Considering this role means examining their influence at the level of policymaking processes, organizational agendas, personal careers, and discursive context, among others. The latter sections of this chapter suggest methods that can be used to put this approach to critical review into practice. The specifics of how these methods were employed in the policy case from El Salvador (the focus of Chaps. 4, 5, and 6) are also detailed.
Interiority as Epistemology: Situating Myself in the Central States Communication Association

I describe my approach to writing this essay as one of interiority, of exploring my deep inner thoughts and reflections on why I did what I did in CSCA over the years. Beyond saying that my CSCA ac...
Characterizing Turbulent Channel Flow

We discuss different methods of characterizing turbulent channel flow in terms of “the number of independent degrees of freedom”. These methods all suggest that the dimension of this system is greater than 10.
To Evaluate the Use of Telemedicine To Provide Intraoperative Neurophysiological Monitoring and Detect Changes in Neurophysiological Responses during Surgery: Observational Study (P02.238)

OBJECTIVE: To evaluate the use of telemedicine to provide intraoperative neurophysiological monitoring (IOM)and detect changes in neurophysiological responses (NPC) during surgery. BACKGROUND: During IOM, NPC in Somatosensory evoked potentials(SSEP)and electroencephalography (EEG) if corrected immediately can reduce neurological deficits (ND) after idiopathic scoliosis fusion(ISF)and carotid endartectomies(CEA). IOM can be delivered via telemedicine, where a technologist connects to the physician using a secure connection for real time data interpretation, as supposed to the traditional model of physician in the operating room. Hospitals and insurance payers are unclear if the telemedicine model is different from the traditionally offered model. DESIGN/METHODS: Observational study conducted between 2004-2012, on 587 and 526 patients who underwent CEA and ISF respectively at various hospitals under in a large health system. Telemedicine was used to provide IOM to all the hospitals in the healthsytem, and in person real time monitoring was provided to the tertiary center. All consecutive patients who underwent the above procedure and whose data could be analyzed were included in the study. Main outcome measures were NPC, ND. Descriptive and regression statistical analysis were performed using SPSS package. Sample size was adequate to detect a significant effect of telemedicine on NPC. RESULTS: The incidence of NPC and ND during and after a CEA were 10.56% and 3.58% respectively. The incidence of NPC and ND during and after ISF were 3.42 % and 0.57% respectively. The use of telemedicine did not increase the adjusted odds of NPC during CEA 1.212 (95% CI 0.69% to 2.12%) or ISF 0.97 (95% CI 0.94 to 1.02). Patients at the tertiary hospital had a higher ND after CEA 2.73 (95% CI 1.16 to 6.3). No difference was noted in ND after ISF. CONCLUSIONS: The use of telemedicine did not have a significant effect on NPC during the CEA or ISF. Disclosure: Dr. Thirumala has nothing to disclose. Dr. Kumar has nothing to disclose. Dr. Crammond has nothing to disclose. Dr. Habeych has nothing to disclose. Dr. Balzer has nothing to disclose.
Direct 4D whole-body PET/CT parametric image reconstruction: Concept and comparison vs. indirect parametric imaging

2133 Objectives Recently, indirect whole-body parametric PET/CT imaging, using Patlak method, has been introduced to enhance tumor quantification and detectability in regions with high background activity, where SUV performs relatively poorly. However, in tumor regions of low-uptake the noise can be significant, due to short dynamic frames employed, affecting contrast and quantitative accuracy. Our aim is to apply a direct 4D reconstruction algorithm to reduce the noise, especially in low-uptake regions. Methods Indirect whole-body parametric imaging consists of two distinct phases: initially, independent 3D OSEM reconstructions are conducted at each frame, followed by linear regression, to estimate the slope and intercept parameters of Patlak. Here, we propose a novel direct 4D whole-body reconstruction algorithm that unifies the two steps into a closed-form OSEM scheme, by incorporating the kinetic modeling within the system matrix and, thus, allowing for estimation of the parametric images directly from the available dynamic sinograms. To compare the performance of the two methods, we conducted Monte Carlo simulations of a 4D PET acquisition consisting of a 6min dynamic scan of the heart, followed by 6 whole-body scans. Data from literature were used to model the dynamics of FDG tracer in a set of liver and lung spherical tumors and their background regions in the XCAT phantom. Results By comparing the slope parametric images, we observe enhanced tumor to background contrast (average over 15 realizations) in direct 4D reconstruction, particularly for the low-uptake tumors (lung). Conclusions Direct 4D parametric image reconstruction can enhance tumor detectability and quantification compared to indirect. In addition to image data size reduction and faster generation of parametric images, our proposed method is designed to address challenges particularly associated with whole-body PET parametric imaging, such as presence of high noise, thus contributing to its clinical adoption.
The Soft Stuff is Still the Hard Stuff

The chapter details the complications and issues associated with integrating and coordinating the introduction and use of technology for homeland security. The use of a steering committee including both technical and organizational personnel is important for the process. The chapter shows the importance of culture and the role of IT people in educating other team members.
Incompetency to Stand Trial

The incompetency doctrine has common law origins, going back at least to mid-seventeenth century England (Group for the Advancement of Psychiatry 1974, pp. 912–915). Blackstone wrote that a defendant who became “mad” after the commission of an offense should not be arraigned “because he is not able to plead... with the advice and caution that he ought” and should not be tried, for “how can he make his defense?” (Blackstone 1783, p. 94; see also Hale 1736, pp. 34–35). Some have traced the common law prohibition on trying the incompetent defendant to the ban against trials in absentia (Foote 1960, p. 834; see, e.g., Frith’s Case 1790; Kinloch’s Case 1746). Others have traced the origins of the doctrine to the difficulties resulting when a defendant frustrated the ritual of the English common law trial by remaining mute instead of pleading to the charge. Without such a plea, the trial could not go forward. In such cases the English court was obliged to determine whether the defendant was “mute by visitation of God” or “mute of malice.” If “mute of malice,” the defendant was subjected to a form of medieval torture—the peine forte et dure—in which increasingly heavier weights were placed upon his chest in an effort to compel him to plead. The category “mute by visitation of God,” the members of whom were spared this painful ritual, originally encompassed the “deaf and dumb,” but gradually was expanded to include “lunatics.” At the discretion of the Chancellor, a jury could be impaneled to conduct an inquest into the defendant’s competency (Group for the Advancement of Psychiatry 1974, pp. 887–88, 912–13; Slovenko 1977, p. 168).
Self-Representation: Pro se Cross-Examination and Revisiting Trauma upon Child Witnesses

In the United States, the right to confront one’s accusers at trial is one of the key components of the adversarial legal process. As a part of this process, defendants are permitted to represent themselves if they decide to do so voluntarily (Faretta v. California 1975). As cross-examination of witnesses is considered essential to the adversarial legal system, child victims can be faced with being personally cross-examined by defendants. In cases involving vulnerable witnesses, such as child abuse victims, there is concern that being cross-examined by the defendant can be highly problematic and create more trauma over and above being cross-examined by a defense attorney. In the United States, there are no laws that explicitly forbid defendants from cross-examining their own victims, and decisions are made on a case-by-case basis. We discuss relevant legal traditions in the United States, laws and procedures followed by other countries that use the adversarial system, current psychological research on cross-examination of child witnesses, the need for further research, and recommendations for ways the United States can protect the rights, well-being, and personal security of vulnerable children.
Combined Mania and Visual-Auditory Hallucinations in a Patient with Isolated Right Thalamic Hemorrhage: the Behavioral Disconnection Syndrome (P6.328)

Objective: To report a first case report of combined acute mania with visual and auditory peduncular hallucinosis in a patient with the right thalamic hemorrhage. Background: It is challenging to localize a single anatomical lesion when neuropsychiatric symptoms are the only manifestations. Thalamus is the complex structure connecting various parts of the brain. From literature searching, combined mania and psychosis has never been reported in a single case with isolated thalamic lesion. Combined visual and auditory hallucination is also rarely reported in isolated thalamic damage. Design/Methods: case report Results: A 55 year-old male without previous history of psychiatric conditions presented with one-week history of acute mania. He had irritability, grandiosity, combative speech, paranoid delusion, high energy levels, decreased need for sleep, pressurized speech and euphoria. Neurological exam showed no focal neurological deficits. Urine drug screen was negative. MRI showed cavernous malformation with hemorrhage involving the dorsomedial and pulvinar parts of right thalamus. Electroencephalography was normal. Risperidone was started. At 4 months follow up, manic symptoms resolved and he stopped taking risperidone. One year later, he presented with acute psychosis. He had vividly visual hallucination (transient texts on his phone, unknown people and colorful airplanes). He also reported musical hallucination at night. He had a good insight to the hallucination. MRI head showed stable cavernous malformation. Risperidone was resumed and effectively improved hallucination. Conclusions: Damage to the thalamus causes the phenomenon of diaschisis which can manifest as various neuropsychiatric symptoms. Damage to the dorsomedial nucleus of thalamus, particular on the right side, results in disconnection of the thalamus from thalamo-cortical-limbic networks. This network disruption causes mania secondary to the dysregulation of emotion, motivation, social conducts, reward seeking behaviors and personality. In a similar manner, pulvinar damage decreases thalamic suppression to the occipital and temporal cortices (release phenomenon) resulting in visual and auditory hallucination. Disclosure: Dr. Julayanont has nothing to disclose. Dr. Ruthirago has nothing to disclose. Dr. Alam has nothing to disclose. Dr. Alderazi has nothing to disclose.
synder: inferring genomic orthologs from synteny maps

Abstract Ortholog inference is a key step in understanding the evolution and function of a gene or other genomic feature. Yet often no similar sequence can be identified, or the true ortholog is hidden among false positives. A solution is to consider the sequence’s genomic context. We present the generic program, synder, for tracing features of interest between genomes based on a synteny map. This approach narrows genomic search-space independently of the sequence of the feature of interest. We illustrate the utility of synder by finding orthologs for the Arabidopsis thaliana 13-member gene family of Nuclear Factor YC transcription factor across the Brassicaceae clade.
Can Simulation Based-Team Training Impact Bedside Teamwork in a Pediatric Intensive Care Unit?

Effective teamwork performance is essential to the delivery of high-quality and safe patient care. In this mixed methodological observational cohort study, we evaluated team performance immediately following a real medical crisis in a pediatric intensive care unit (PICU) following implementation of a simulation-based team training (SBTT) program. Comparison of teamwork skills when rated by study observers demonstrated a statistically significant improvement in 12 out of 15 composite teamwork skills during real emergency events following SBTT (p
Do consequences of hardship narrow in later life? The impact of hardship on self-rated health among older adults.

Abstract Purpose The purpose of this study was to investigate the association between hardship and self-rated health among older adults and determine whether this association differed by age. Methods Using data from the 2014 Survey of Income and Program Participation, we conducted logistic regression analysis to examine the association between hardship and self-rated health among adults aged 55 years and older in the United States, and the moderating effect of age on this relationship. Analyses were weighted using replicate weights provided by the survey. Indicators of hardship were dichotomized (1 = experienced hardship, 0 = no hardship). Results Analyses indicated that individuals who were unable to pay utility bills, unable to pay rent or mortgage, or who experienced food insecurity had higher odds of reporting fair or poor health relative to those not experiencing these hardships. The association between hardship and self-rated health was moderated by age. Conclusions Hardship is directly relevant to health outcomes as it signals unfulfilled needs experienced by individuals lacking adequate economic resources. This study contributes to our understanding of the role of age in the association between hardship and self-rated health.
Disordered Eating in Asian American Women: Sociocultural and Culture-Specific Predictors

Asian American women demonstrate higher rates of disordered eating than other women of color and comparable rates to European American women. Research suggests that leading sociocultural predictors, namely pressures for thinness and thin-ideal internalization, are predictive of disordered eating in Asian American women; however, no known studies have tested the intersection of sociocultural and culture-specific variables (e.g., ethnic identity, biculturalism, acculturative stress) to further elucidate disordered eating risk in this vulnerable, understudied group. Accordingly, this project used path analysis to simultaneously examine the role of sociocultural and culture-specific effects on disordered eating in Asian American college women (N = 430). Self-report measures assessing disordered eating, sociocultural (pressures for thinness; thin-ideal internalization) and culture-specific (ethnic identity, biculturalism, acculturative stress) variables revealed that a number of sociocultural and culture-specific factors are predictive of disordered eating. Consistent with prior research, heightened perceived pressures for thinness and thin-ideal internalization were predictive of disordered eating, and thin-ideal internalization partially mediated the relationship between pressures for thinness and disordered eating. Acculturative stress predicted disordered eating and fully accounted for the inverse relationship between biculturalism and disordered eating. Overall, findings highlighted the salience of sociocultural predictors for disordered eating in Asian American women and identified biculturalism and acculturative stress as culture-specific contributors that may uniquely impact vulnerability to disordered eating in Asian American women. Thus, the combined consideration of sociocultural and culture-specific factors may be important in disordered eating research and in the development of individualized treatment plans for Asian American women.
Interpretation of oxygen disappearance rates in brain cortex following total ischaemia.

The purpose of this project was to attempt to obtain a more precise interpretation of the meaning of the rates of disappearance curves of PO2 in brain cortex following complete ischaemia as measured with microelectrodes. The following three specific studies are discussed: (1) Analysis of individual PO2 disappearance as a function of time. (2) Analysis of the rate of disappearance as a function of the initial tissue PO2. (3) Analysis of the rates of disappearance curves with respect to the possibility of prediction of local metabolic rates.
Making causal inferences about treatment effect sizes from observational datasets

In the era of big data and cloud computing, analysts need statistical models to go beyond predicting outcomes to forecasting how outcomes change when decision-makers intervene to change one or more...
Exploring the pedagogical affordances of a collaborative board game in a dual language immersion classroom

In this study, we present an educational board game designed to promote both mathematics and Chinese language learning. We use text‐mining techniques to analyze dialog by 40 students, in six groups playing a board game in a dual language immersion context. Our findings provide evidence to support past claims and arguments that play and specifically play within board games can provide a learning environment in which students can experiment with concepts and language without fear of failure. In our study, we not only found that learners were willing and excited to use their L2 skills within the context of the game but also that the board game promoted peer learning, which subsequently provided support for both math and language development.
Semistar Operations on Commutative Rings

In this chapter, we develop the theory of semistar operations on commutative rings and apply the theory to study many important classes of integral domains, such as the Dedekind domains, Prufer domains, UFDs, Krull domains, and PVMDs, along with natural generalizations of these classes of domains to rings with zerodivisors. We postpone the use of local methods until Chapter 3. All rings in Chapters 2– 4 are assumed commutative with identity.
Multiple myeloma presenting as plasmacytoma causing obstructive jaundice.

Jaundice, weight loss, and anorexia are common symptoms that raise concern for pancreatic malignancy. Although the most common form of pancreatic malignancy is pancreatic adenocarcinoma, not all pa...
Extraventricular neurocytoma with ganglioid differentiation of the sellar and parasellar regions in an elderly patient: A case report.

Background Extraventricular neurocytoma (EVN) is a rare variant of central neurocytoma which arises outside of the ventricular system. Diffuse ganglioid differentiation is a characteristic seen in a subset of these tumors which has an uncertain prognostic significance. Typically, EVN presents in children and young adults. Given the rarity of this tumor, the natural history and response to treatments remain unclear. Case Description We present a case of EVN with diffuse ganglioid differentiation in a 70-year-old male which arose in the midline parasellar region and extended into the third ventricle. This is the oldest such patient reported. Despite prior reports that extremes of age are associated with more aggressive behavior, the tumor in this case did not exhibit such an aggressive course. Conclusion In this report, we review the natural history and clinical course of this patient and summarize the literature regarding this rare pathological entity. Our patient responded well to therapy despite older age, ganglioid differentiation, and higher mitotic index.
Clinical characteristics and outcomes of signet ring cell carcinoma of the stomach: A retrospective analysis of SEER database.

e16572Background: Signet ring cell carcinoma (SRCC) of the stomach accounts for 8 to 30% of all gastric cancers, however the incidence has been rising. We performed a Surveillance, Epidemiology and...
A Playlist as A Metaphor for Engaging in a Collaborative Self-Study of Mathematics Teacher Educator Practices

Mathematics teacher educators can use video clips of children solving mathematics problems to help teacher candidates attend to nuanced aspects of teaching and learning mathematics. However, the pr...
The Civil Rights Act of 1964: Beyond Race to Employment Discrimination Based on Sex: The 'Three Letter Word' That Has Continued to Vex Society and The United States Supreme Court

This article is a comprehensive review of the Civil Rights Act of 1964, more specifically, Title VII, which outlawed discrimination based upon, “race, color, creed, national origin, and sex.” The article traces the legislative genesis of the Act, the function of the Equal Employment Opportunity Commission, and discusses some of the major cases decided by the United States Supreme Court and other federal courts that have defined both the reaches and limits of the legislation which initially focused on prohibiting discrimination based on “race.” The article then focuses on discrimination based on “sex” and highlights the role the United States Supreme Court has played in fleshing out the parameters of employment discrimination from the 1960s through the historic decision reached by the Court in June of 2020 in Bostock v. Clayton County, Georgia, relating to sexual orientation, transgender status, and sex stereotyping.
Abstract 4932: mTORC1 regulates FAK phosphorylation

The mammalian target of rapamycin (mTOR) functions as two complexes, mTORC1 and mTORC2, regulating cell growth, proliferation, survival, and motility. Previous studies have shown that mTORC2 controls cytoskeleton and cell motility. Recently, we have demonstrated that both mTORC1 and mTORC2 participate in the regulation of cell motility. Further studies have shown that rapamycin suppresses IGF-I induced cell motility by inhibiting S6K1-mediated phosphorylation of focal adhesion kinase (FAK), protein phosphatase 2A (PP2A)-mediated phosphorylation of Erk1/2, as well as expression and activities of the small GTPases (RhoA, Cdc42 and Rac1). As FAK plays a pivotal role in the regulation of cell motility, this study was set to determine how mTORC1 regulates the phosphorylation of FAK. By co-immunoprecipitation (co-IP) and immunoblotting (IB), we failed to detect a physical interaction between FAK and S6K1, suggesting that S6K1 may regulate the phosphorylation of FAK indirectly. Besides, knockdown of protein phosphatase 2A (PP2A) enhanced the phosphorylation of FAK and conferred resistance to rapamycin inhibition of IGF-I-stimulated phosphorylation of FAK. However, the co-IP/IB results revealed no direct interaction between FAK and PP2A either. Of interest, knockdown of protein phosphatase 5 (PP5) suppressed IGF-I stimulated cell motility, while knockdown of ATG13 increased IGF-I stimulated cell motility, suggesting that PP5 positively regulates cell motility, whereas ATG13 negatively regulates cell motility. It is well known that PP5 is an anti-apoptotic phosphatase, negatively regulating the ASK1-JNK cascade, and mTORC1 regulates autophagy through the ULK1/2-ATG13-FIP200 complex. Further research will determine how mTORC1 regulates cell motility in part by regulating the phosphorylation of FAK via S6K1, PP2A, PP5 and ATG13. (Supported by the Feist-Weiller Cancer Center, LSU Health Sciences Center, Shreveport, LA, USA.) Citation Format: Lin Li, Yan Luo, Lei Liu, Shile Huang. mTORC1 regulates FAK phosphorylation [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4932.
Quantifying the Multi-Objective Cost of Uncertainty

Various real-world applications involve modeling complex systems with immense uncertainty and optimizing multiple objectives based on the uncertain model. Quantifying the impact of the model uncertainty on the given operational objectives is critical for designing optimal experiments that can most effectively reduce the uncertainty that affect the objectives pertinent to the application at hand. In this paper, we propose the concept of mean multi-objective cost of uncertainty (multi-objective MOCU) that can be used for objective-based quantification of uncertainty for complex uncertain systems considering multiple operational objectives. We provide several illustrative examples that demonstrate the concept and strengths of the proposed multi-objective MOCU. Furthermore, we present a real-world example based on the mammalian cell cycle network to demonstrate how the multi-objective MOCU can be used for quantifying the operational impact of model uncertainty when there are multiple, possibly competing, objectives.
The Valuation Impact of PCAOB International Inspections on U.S. Multinational Corporations

Although the Sarbanes-Oxley Act of 2002 mandates that all auditors of public issuers in the United States are subject to Public Company Accounting Oversight Board (PCAOB) inspection, certain foreign jurisdictions prevent the PCAOB from inspecting their audit firms. Between January 2011 and November 2017, the PCAOB issued a series of 16 disclosures announcing Cooperative Agreements with foreign regulators who previously prohibited PCAOB inspections. We exploit the staggered introduction of the PCAOB international inspection program to examine whether PCAOB cross-border audit oversight affects the valuation of U.S. Multinational Corporations (MNCs). Specifically, we examine the returns of U.S. MNCs with substantial operations in certain foreign countries to news about auditors from those countries not being, and then becoming, subject to PCAOB inspection. We document a significantly negative (positive) market reaction to news that the PCAOB does not have (subsequently gains) access to inspect certain foreign participating auditors. Consistent with cross-sectional predictions, we find the valuation impact is stronger for U.S. MNCs with weaker external monitoring, greater overseas presence, and foreign operations in countries with poorer investor protections. Overall, the results are consistent with investors valuing PCAOB regulatory oversight abroad.
Impedance Matching to Axion Dark Matter: Considerations of the Photon-Electron Interaction

We introduce the concept of impedance matching to axion dark matter by posing the question of why axion detection is difficult, even though there is enough power in each square meter of incident dark-matter flux to energize a LED light bulb. By quantifying backreaction on the axion field, we show that a small axion-photon coupling does not by itself prevent an order-unity fraction of the dark matter from being absorbed through optimal impedance match. We further show, in contrast, that the electromagnetic charges and the self-impedance of their coupling to photons provide the principal constraint on power absorption integrated across a search band. Using the equations of axion electrodynamics, we demonstrate stringent limitations on absorbed power in linear, time-invariant, passive receivers. Our results yield fundamental constraints, arising from the photon-electron interaction, on improving integrated power absorption beyond the cavity haloscope technique. The analysis also has significant practical implications, showing apparent tension with the sensitivity projections for a number of planned axion searches. We additionally provide a basis for more accurate signal power calculations and calibration models, especially for receivers using multi-wavelength open configurations such as dish antennas and dielectric haloscopes.
Have Your Cake and Eat it Too? Managing Knowledge in Hybrid Agile-Traditional Development Projects

This research examines how knowledge management elements of systems development projects are adapted to correspond with the increasing use of agile practices. Using a single, longitudinal case study, we draw on interview data from an initial CRM implementation that used a traditional approach, followed by a second project phase employing a hybrid agile-traditional approach. Oriented using the concept of ambidexterity, our findings suggest that some knowledge management elements remained traditional, others became strongly agile, and some integrated both approaches together in a hybrid manner. Our study aids practitioners by providing insights into the opportunities and pitfalls of managing knowledge within hybrid development projects. For researchers, this paper applies the concept of ambidexterity in an agile development context as it relates to knowledge management. Our findings extend the literature on the incremental trade-offs that companies face when attempting to simultaneously explore and exploit two development approaches.
Manufacturing Systems Evaluation

Environmentally conscious manufacturing is the production of products using processes and techniques selected to have the least impact on the environment while still being economically viable. This Chapter discusses several techniques for assessing and evaluating environmentally conscious manufacturing performance of manufacturing systems. This provides the basis for making evaluations of improvement areas and performing the tasks necessary to formulate improvement projects. The goal of this Chapter is to provide guidance to assist the industrial engineer in finding better methods and techniques to make the overall manufacturing system more responsive to the goals of environmentally conscious manufacturing. The study determines that ISO 14001 is a suitable plan to pursue and may be essential to the business practices of the firm if it is used properly. Keywords: hazardous materials; life cycle assessment; metasystem; PDCA cycle; quality defect reports
Comparative Studies on the Modification of Specific Disulfide Bonds of Trypsinogen and Chymotrypsinogen

Abstract Two homologous disulfides of trypsinogen and chymotrypsinogen differ in their reactivity toward specific reducing agents. Disulfide 179 to 203 of trypsinogen was readily reduced with either 0.1 m sodium borohydride or 0.0005 m dithioerythritol. A second disulfide bond, at residues 122 and 189, required 0.01 m dithioerythritol for cleavage to occur. Disulfide 191 to 220 of chymotrypsinogen was reduced with 0.01 m dithioerythritol, while disulfide 136 to 201 was unreactive. The relative reactivity of the bonds provides a way to characterize the behavior of each and to classify the bonds as fully exposed (reactive with sodium borohydride and 0.0005 m dithioerythritol), partly buried (reactive with 0.01 m dithioerythritol), and buried (unreactive in the native state). These observations suggest that the two zymogens differ in conformation in regions of homologous sequences. S(Carboxymethylcysteine)4-(122, 179, 189, 203)-trypsinogen was activated with trypsin at pH 5, and the concentration of active molecules was estimated with p-nitrophenyl-p'-guanidinobenzoate. The rate of formation of active sites and the yield were similar to the activation of the dicarboxymethyl derivative (Light, A., Hardwick, B. C., Hatfield, L. M., and Sondack, D. L., J. Biol. Chem., 244, 6289 (1969)). The formation of catalytically active molecules from the modified zymogen shows that the two disulfides are non-essential structural elements. Chromatographically purified α- and β-trypsin, and inhibited trypsins, were not reduced in a specific manner with dithioerythritol. Instead, a low yield was observed of randomly reduced disulfides. The apparent reduction of two disulfides of a commercial trypsin sample (Light, A., and Sinha, N. K., J. Biol. Chem., 242, 1358 (1967)) was caused instead by the reduction of the inert protein component. The difference in reactivity of the disulfides of trypsinogen and trypsin suggests that the conformation change accompanying the activation process includes the region of disulfide 179 to 203.
Resonance Excitation: A Possible Interpretation of the 3-kpc Arm

A minor oval distortion or an uneven distribution of mass in the central region of the Galaxy may excite an outgoing spiral wave that closely resembles the observed 3-kpc arm. The wave is generated by a resonance excitation mechanism at the outer Lindblad resonance corresponding to the pattern frequency of the oval distortion or of the uneven distribution of the mass. An expansion velocity of 53 km/sec associated with the wave crest requires a perturbational field of 5% of the local mean gravitational field. The calculations are based on a non-linear analysis of gas motions in a disk system with the inclusion of self-gravitation and viscosity.