cssi/SciSciGPT-SciSciNet huggingface dataset:
SERUM METAL LEVELS FOR THE DIAGNOSIS OF ADVERSE LOCAL TISSUE REACTIONS IN METAL-ON-POLYETHYLENE TOTAL HIP ARTHROPLASTY

Recently, corrosion at the head-neck junction in metal-on-polyethylene bearing total hip arthroplasty (THA) has been recognized as a cause of adverse local tissue reactions (ALTR). Serum metal levels have been advocated as a tool for the diagnosis of ALTR, however no prior studies have specifically examined their utility. The purpose of this study was to determine the optimal cut-off values for serum cobalt and chromium in diagnosing ALTR after metal-on-polyethylene bearing THA. We reviewed 447 consecutive patients with serum metal levels tested at our institution and identified 62 with a metal-on-polyethylene bearing who had axial imaging or underwent reoperation to confirm the presence or absence of ALTR. Receiver operating characteristic curves were produced to identify cut-off thresholds to optimize sensitivity and diagnostic test performance was characterized. 42 Of the 62 patients (66%) were positive for an ALTR. The best test for the diagnosis of ALTR was the serum cobalt level (area under the curve [AUC]=99%). A threshold cut-off of ≥ 1.0 ng/ml had a sensitivity of 100%, specificity of 90%, positive predictive value (PPV) of 96%, and negative predictive value (NPV) of 100%. Serum chromium levels were also diagnostic (AUC=87%). A threshold cut-off of ≥ 0.15 ng/ml had a sensitivity of 100%, specificity of 50%, PPV of 81%, and NPV of 100%. Finally, serum cobalt to chromium ratio was also helpful for diagnosis (AUC=90%). A threshold cut-off of 1.4 for the cobalt to chromium ratio offered a sensitivity of 93%, specificity of 70%, PPV of 87%, and NPV of 82%. Measurement of serum cobalt with a threshold value of 1.0 ng/ml in our experience is the best test for identifying the presence of ALTR in patients with a metal-on-polyethylene THA. Measurement of chromium and the ratio of cobalt to chromium are also of value.
Renal Mass Imaging: The Internist’s Role

The busy internist will encounter numerous renal masses when ordering nonurologic imaging. Concise and quick delineation of cystic from solid masses is necessary. Cystic masses constitute the majority of these masses and once their nature is diagnosed, they require no further work-up or referral. Often, a single imaging technique is unable to confidently establish the cystic nature of a renal mass. Proper selection of an additional imaging modality will often be successful in establishing the cystic characteristics of a benign mass. Referral to a urologist is not necessary in this setting, since the internist can coordinate the imaging evaluation with proper radiologic consultation. Alternatively, when a mass is determined to be solid, urologic consultation and surgical evaluation are necessary. Minimization of the imaging sequence and hospitalization are critical in the diagnostic-related group era. Aimless wandering in the quagmire of imaging techniques is very expensive and nonproductive. Proper selection of one or two imaging tools and occasionally needle puncture should produce clarification of the cystic or solid nature of renal mass. On the basis of our experience, we have designed an imaging algorithm that provides a simple and concise approach to the diagnosis of a renal mass. It differs in design from that previously suggested by us and others because of decreased emphasis on nuclear medicine and greater emphasis on computed tomography. The more pivotal position assumed by computed tomography is based on improved scanner design and several large series attesting to the accuracy and cost-effectiveness of this imaging technique. It behooves internists to appreciate the role of various imaging tools in evaluating a renal mass. With radiologic consultation, internists should strive to confidently establish the cystic nature of a renal mass and to refer to a urologist solid masses or those whose nature remains persistently equivocal.
Complications of Urinary Tract Undiversion

SUMMARY The complications of urinary tract undiversion can be divided into those asssociated with patient selection, choice of techniques, and early and late surgical difficulties. Patient selection must take into account the original reason for diversion (incontinence, hydronephrosis, reflux, or renal functional impairment), current renal function and bladder dynamics, upper urinary tract anatomy, and pyschosocial considerations. Technical considerations require versatility and ingenuity on the part of the surgeon. Although direct uroepithelium-to-uroepithelium continuity is ideal, this often cannot be accomplished. A variety of techniques including transureteroureterostomy, psoas hitch of the bladder, bladder augmentation, ileocecal and colon interposition, and autotransplantation can be used to facilitate the refunctionalization of the urinary tract. One must monitor the patient postoperatively for potential early and late complications. Meticulous attention to surgical details will help minimize these. The ultimate goal is to achieve stable renal function and urinary continence.
Teaching Secure Cloud Computing Concepts with Open Source CloudSim Environment.

Cloud Computing is growing very fast and many universities are offering Cloud Computing courses on undergraduate and graduate levels, however, most of them are seminar type courses without hands-on learning experience for students. Hands-on learning, i.e. learning by doing is very crucial to help students understand better on the concepts of cloud computing such as security, task scheduling and network topology. In this paper, we propose to enhance Cloud Computing education with open source simulation tools such as CloudSim. We apply CloudSim to create labware for students to gain hands-on experience and understand different aspects of Cloud Computing more efficiently and effectively. The preliminary feedback on student learning outcomes is very encouraging.
Interstitial Nephritis, Proteinuria, and Renal Failure Caused by Nonsteroidal Anti-Inflammatory Drugs. Immunologic Characterization of the Inflammatory Infiltrate

Nine patients with the unusual combination of renal failure, nephrotic-range proteinuria, and biopsy-proved interstitial nephritis are described. Six of these patients had received nonsteroidal anti-inflammatory agents (three fenoprofen, one ibuprofen, one zomepirac, and one tolmetin). The remaining three patients had no history of exposure to drugs known to cause interstitial nephritis. Immunologic characterization of the infiltrating cells with monoclonal antibodies showed that the majority of cells in most cases were cytotoxic T cells, although some B cells were present in all cases. Giant collecting duct cells were seen in half the patients with drug exposure but in none of the others. Otherwise, there were no conspicuous morphologic differences between patients with and without drug exposure. Many of the patients had associated glomerular abnormalities. Only the zomepirac and tolmetin recipients showed pure interstitial disease. The three fenoprofen recipients and the zomepirac and tolmetin recipients regained normal renal function after the drug was discontinued. The combination of renal failure, nephrotic range proteinuria, and interstitial nephritis is one form of nephrotoxicity observed in patients treated with nonsteroidal anti-inflammatory agents. However, this lesion, which may be mediated by cytotoxic T cells, may also be seen rarely in patients with no apparent drug exposure.
Reasons women do not seek health care for dysmenorrhea.

Aims and objectives To identify and describe reasons women do not seek health care for dysmenorrhea symptoms. Background Although dysmenorrhea is highly prevalent among women, can cause significant disruptions in their daily lives, and may increase their risk for future chronic pain conditions, few women seek health care for dysmenorrhea. A better understanding of why women do not seek health care is necessary to develop strategies that facilitate care seeking and optimal symptom management. Design A qualitative descriptive design was used to guide the study and summarise text responses to an open-ended survey question. Methods Participants in an online survey study who had not sought health care for dysmenorrhea (N = 509) were asked to write about their reasons for not seeking care. Data were collected in January and February 2015. Participants’ text responses were analysed using qualitative content analysis. Results Nine categories of reasons were identified as follows: assuming symptoms are normal, preferring to self-manage symptoms, having limited resources, thinking providers would not offer help, being unaware of treatment options, considering symptoms to be tolerable, being wary of available treatments, feeling embarrassed or afraid to seek care and not seeking health care generally. Conclusions Findings can guide the development of strategies to promote care seeking and inform policy and clinical practice to improve dysmenorrhea management. Relevance to clinical practice Findings underscore the need to provide routine screening for dysmenorrhea, avoid dismissing dysmenorrhea symptoms, initiate discussions and provide education about dysmenorrhea, provide treatments options based on evidence and women's preferences and raise public awareness of dysmenorrhea and its impact.
EXTERNAL FIXATION FOR CLOSED PAEDIATRIC TIBIAL SHIFT FRACTURES: A COHORT STUDY

BACKGROUND Most closed tibial fractures in children can be treated conservatively. On the occasions that surgical intervention is required, there are various options available to stabilise the fracture. We would like to present our experience of using monolateral external fixators in the management of closed tibial fractures. Aim We sought to assess the time to healing, limb alignment, and complications observed in a cohort of tibial fractures treated with external fixation. METHODS Our limb reconstruction database was used to identify patients who underwent monolateral external fixation for a closed tibial fracture between January 2008 and December 2016. Radiographs of all patients were assessed to determine the original fracture pattern. Time to union was assessed as the time when the fixator was removed and the patient allowed to mobilise independently without any further support of the limb. The presence or absence of residual deformity was assessed on final follow-up radiographs. RESULTS 22 patients fulfilled the inclusion criteria. 78% of patients had both tibial and fibular fracture. The mean age at injury was 12 years. The mean time taken for the fracture to heal was 18 weeks. The total duration of follow-up averaged 9 months. The mean Valgus deformity at the final follow up was 4 degrees and the mean Varus deformity was 4 degrees. The mean procurvatum was 4.2 degrees and the mean recurvatum was 6 degrees. 50% of patients had pin site infection. Two patients had tibio fibular synostosis. None of them had leg length discrepancy or refractures. There were no episodes of osteomyelitis. CONCLUSIONS Five degree of coronal plane deformity and ten degree of sagittal deformity were considered as acceptable in children due to their potential for remodeling. All our patients had acceptable levels of residual deformity. In our opinion monolateral external fixation represents a safe and effective option.
Design of Thermally Stressed Panels Subject to Transonic Flutter Constraints

The objective of this study is to design a two-dimensional panel subject to transonic flutter constraints in the presence of an extreme thermal environment. The unsteady aerodynamic model is based ...
Chronic inflammatory demyelinating polyneuropathy.

Purpose of reviewAs a syndrome with typical and atypical cases, chronic inflammatory demyelinating polyneuropathy (CIDP) has been a difficult disorder to diagnose and treat. The pathophysiologic basis for CIDP has not been established, contributing to the challenges in dealing with these patients. H
On the penalty stabilization mechanism for upwind discontinuous Galerkin formulations of first order hyperbolic systems

Abstract Penalty fluxes are dissipative numerical fluxes for high order discontinuous Galerkin (DG) methods which depend on a penalization parameter (Warburton, 2013; Ye et al., 2016). We investigate the dependence of the spectra of high order DG discretizations on this parameter, and show that as its value increases, the spectrum of the DG discretization splits into two disjoint sets of eigenvalues. One set converges to the eigenvalues of a conforming discretization, while the other set corresponds to spurious eigenvalues which are damped proportionally to τ . Numerical experiments also demonstrate that undamped spurious modes present in both in the limit of zero and large penalization parameters are damped for moderate values of the upwind parameter.
Constant-Time Distributed Scheduling Policies for Ad Hoc Wireless Networks

We propose a new class of distributed scheduling policies for ad hoc wireless networks that can achieve provable capacity regions. Previously known scheduling policies that guarantee comparable capacity regions are either centralized or require computation time that increases with the size of the network. In contrast, the unique feature of the proposed distributed scheduling policies is that they are constant-time policies, i.e., given a fixed approximation ratio and a bounded maximum node-degree of the network, the time needed for computing a new schedule is independent of the network size. Hence, they can be easily deployed in large networks.
Galactos: computing the anisotropic 3-point correlation function for 2 billion galaxies

The nature of dark energy and the complete theory of gravity are two central questions currently facing cosmology. A vital tool for addressing them is the 3-point correlation function (3PCF), which probes deviations from a spatially random distribution of galaxies. However, the 3PCF's formidable computational expense has prevented its application to astronomical surveys comprising millions to billions of galaxies. We present Galactos, a high-performance implementation of a novel, O(N2) algorithm that uses a load-balanced k-d tree and spherical harmonic expansions to compute the anisotropic 3PCF. Our implementation is optimized for the Intel Xeon Phi architecture, exploiting SIMD parallelism, instruction and thread concurrency, and significant L1 and L2 cache reuse, reaching 39% of peak performance on a single node. Galactos scales to the full Cori system, achieving 9.8 PF (peak) and 5.06 PF (sustained) across 9636 nodes, making the 3PCF easily computable for all galaxies in the observable universe.
Risk Management Using Cyber-Threat Information Sharing and Cyber-Insurance

Critical infrastructure systems spanning from transportation to nuclear operations are vulnerable to cyber attacks. Cyber-insurance and cyber-threat information sharing are two prominent mechanisms to defend cybersecurity issues proactively. However, standardization and realization of these choices have many bottlenecks. In this paper, we discuss the benefits and importance of cybersecurity information sharing and cyber-insurance in the current cyber-warfare situation. We model a standard game theoretic participation model for cybersecurity information exchange (CYBEX) and discuss the applicability of economic tools in addressing important issues related to CYBEX and cyber-insurance. We also pose several open research challenges, which need to be addressed for developing a robust cyber-risk management capability.
THE CEMENTED ALL-POLY TIBIA: A BUNDLED PAYMENT SOLUTION

Background Total knee arthroplasty (TKA) overall is a very reliable, durable procedure. Biomechanical studies have suggested superior stress distribution in metal-backed tibial trays, however, these results have not been universally observed clinically. Currently, there is a paucity of information examining the survival and outcomes of all-polyethylene tibial components. Methods We reviewed 31,939 patients undergoing a primary TKA over a 43-year period (1970–2013). There were 28,224 (88%) metal-backed and 3,715 (12%) all-polyethylene tibial components. The metal-backed and all-polyethylene groups had comparable demographics with respect to sex distribution (57% female for both) mean age (67 vs. 71 years), and mean BMI (31.6 vs. 31.1). Mean follow-up was 7 years (maximum 40 years). Results The purpose of this investigation was to analyze the outcomes of all-polyethylene compared to metal-backed components in TKA and to determine (1) is there a difference in overall survival? All polyethylene tibial components had improved survivorship (P Conclusions The use of all-polyethylene tibias should be considered for the majority of patients, regardless of age and BMI.
Exploring societal-level privacy rules for talking about miscarriage:

Communication privacy management (CPM) theory posits that culturally specific understandings of privacy guide how people manage private information in everyday conversations. We use the context of ...
Prefrontal Control of Visual Distraction

Avoiding distraction by conspicuous but irrelevant stimuli is critical to accomplishing daily tasks. Regions of prefrontal cortex control attention by enhancing the representation of task-relevant information in sensory cortex, which can be measured in modulation of both single neurons and event-related electrical potentials (ERPs) on the cranial surface [1, 2]. When irrelevant information is particularly conspicuous, it can distract attention and interfere with the selection of behaviorally relevant information. Such distraction can be minimized via top-down control [3-5], but the cognitive and neural mechanisms giving rise to this control over distraction remain uncertain and debated [6-9]. Bridging neurophysiology to electrophysiology, we simultaneously recorded neurons in prefrontal cortex and ERPs over extrastriate visual cortex to track the processing of salient distractors during a visual search task. Critically, when the salient distractor was successfully ignored, but not otherwise, we observed robust suppression of salient distractor representations. Like target selection, the distractor suppression was observed in prefrontal cortex before it appeared over extrastriate cortical areas. Furthermore, all prefrontal neurons that showed suppression of the task-irrelevant distractor also contributed to selecting the target. This suggests a common prefrontal mechanism is responsible for both selecting task-relevant and suppressing task-irrelevant information in sensory cortex. Taken together, our results resolve a long-standing debate over the mechanisms that prevent distraction, and provide the first evidence directly linking suppressed neural firing in prefrontal cortex with surface ERP measures of distractor suppression.
RISE to the occasion? A critique of the World Bank’s Regulatory Indicators for Sustainable Energy

Abstract The World Bank’s Regulatory Indicators for Sustainable Energy (RISE) scorecard evaluates countries’ sustainable energy policies against global ‘best practices.’ Here I demonstrate that many of these so-called best practices are inappropriate in the context of limited state capacity. Using several examples from the RISE report, I argue that the World Bank should replace the pursuit of one-size-fits-all best practices and instead focus on generating knowledge about the contextual fit of different policy approaches. Drawing inspiration from research on adaptive reform strategies in the developing country context, I argue that an adaptive and flexible strategy could help national governments to surmount obstacles to policies that over time make the dream of sustainable energy for all a global reality.
On the existence and uniqueness of stationary equilibrium in Bewley economies with production

Abstract I prove existence of stationary recursive competitive equilibrium in Bewley economies with production under specifications in which (i) the utility function is allowed to be unbounded, and (ii) the underlying discrete idiosyncratic productivity process can take any form, aside from mild restrictions. Some of the intermediate results provide theoretical basis for assumptions often made in the quantitative macroeconomics literature. By providing an example, I illustrate that the equilibrium is not necessarily unique, even under typical specifications of the model, and discuss the underlying reasons for multiplicity.
The recourse rule, regulatory arbitrage, and the financial crisis

In November 2001, regulators finalized the “Recourse Rule.” The rule lowered risk weights, and therefore commercial bank holding company capital requirements, to 0.2 for holdings of AAA- and AA-rated “private label” securitization tranches, created by investment banks and securitizing commercial bank holding company subsidiaries; risk weights for A-rated holdings equaled 0.5. The rule’s aim was to encourage securitization, but not risk-taking. Regulators indicated that the rule would apply to larger holding companies, without identifying them. Using bank holding companies with subsidiaries that commented on the proposed rule-makings as a treatment variable, average treatment effects from a fully flexible difference-in-differences model indicate that treated banks increased their holdings of the highly rated tranches relative to total assets, while other holding companies, on average, did not. Holding companies with greater highly rated tranche holdings also experienced greater increases in risk after Q1 2008, which suggests that poor performance may have been unanticipated.
A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei

Recent advances in magnetic resonance imaging methods, including data acquisition, pre-processing and analysis, have benefited research on the contributions of subcortical brain nuclei to human cognition and behavior. At the same time, these developments have led to an increasing need for a high-resolution probabilistic in vivo anatomical atlas of subcortical nuclei. In order to address this need, we constructed high spatial resolution, three-dimensional templates, using high-accuracy diffeomorphic registration of T1- and T2- weighted structural images from 168 typical adults between 22 and 35 years old. In these templates, many tissue boundaries are clearly visible, which would otherwise be impossible to delineate in data from individual studies. The resulting delineations of subcortical nuclei complement current histology-based atlases. We further created a companion library of software tools for atlas development, to offer an open and evolving resource for the creation of a crowd-sourced in vivo probabilistic anatomical atlas of the human brain.
Centralized policymaking and informational lobbying

This paper compares centralized and decentralized policymaking in a game theoretic model of informational lobbying and political contributions. In the model, an interest group first produces verifiable evidence about the welfare effects of its preferred policy and then engages in monetary lobbying. The analysis highlights a new channel through which centralized policymaking affects social welfare: centralization can incentivize the interest group to produce less informative evidence, leading to less informed policy decisions and lower social welfare. This channel is most relevant when the interest group is only willing to pay small political contributions to policymakers. When the interest group’s willingness to pay becomes larger, centralized policymaking affects social welfare by changing the degree of political capture.
Impact of Nab-Paclitaxel-based Second-line Chemotherapy in Metastatic Pancreatic Cancer.

Background Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with median survival of 20% at 1 year. We conducted a retrospective study to assess the efficacy and tolerability of nab-paclitaxel (NP)-based second-line chemotherapy in metastatic PDAC. Patients and methods The Indiana University Simon Cancer Center pancreatic cancer program was used to identify patients with metastatic PDAC who received any second-line chemotherapy. Demographic, clinical and outcomes data were collected by manual chart abstraction. Patients were divided into two groups: a NP-based treatment group and a non- NP-based treatment group. Overall (OS) and progression-free (PFS) survival were estimated using Kaplan-Meier method. Cox proportional hazards regression was used for multivariate analyses. Results A total of 120 patients received second-line chemotherapy. There were 47 (39%) patients in the NP group and 73 (61%) in the non-NP group. As compared to the non-NP group, the NP group showed improved median PFS [2.8 vs. 2.1 months; hazard ratio (HR)=0.62, 95% confidence interval (CI)=0.38-1.02; p=0.06] and median OS (7.5 vs. 4.7 months; HR=0.67, 95% CI=0.45-1.00; p=0.05). Multivariate analyses adjusted for age showed a significantly improved PFS (adjusted HR=0.60, 95% CI=0.36-0.98; p=0.04) and a suggestion of improved OS (adjusted HR=0.67, 95% CI=0.44-1.01, p=0.05) in the NP group as compared to non-NP group. Serious adverse events were seen in 13.3% of patients in the non-NP group and 17.1% patients in the NP group. Conclusion In a single-institution retrospective cohort study, we report a significant improvement in the PFS and suggestion of improvement in the OS with NP-based second-line chemotherapy with an acceptable toxicity rate.
INTRA-OPERATIVE MEDIAL COLLATERAL LIGAMENT INJURY DURING TOTAL KNEE ARTHROPLASTY: A BRACING SOLUTION

Controversy remains regarding the optimal treatment for iatrogenic injury to the medial collateral ligament (MCL) during primary total knee arthroplasty (TKA). Some authors have recommended converting to a prosthesis that provides varus/valgus constraint while others have recommended primary repair. In this study we report the results of a 45 patients who sustained intra-operative MCL injuries during primary TKA that were treated with primary repair. Of 3922 consecutive primary TKA there were 48 (1.2%) intra-operative MCL lacerations or avulsions. One patient was lost and one died before 24-month follow-up. All but one patient underwent primary repair with placement of components without varus/valgus constraint. This left 45 knees with a mean follow up of 89 months (range, 24 – 214 months). The mean HSS knee scores increased from 47 to 85 points (p Primary repair with 6 weeks of post-operative hinged bracing after iatrogenic injury to the MCL during primary TKA was successful at preventing instability although stiffness was seen in approximately 10% of patients. The increased morbidity associated with implantation of a semi-constrained or constrained implant may be unwarranted in this situation.
Improved approximations for cubic bipartite and cubic TSP

We show improved approximation guarantees for the traveling salesman problem on cubic bipartite graphs and cubic graphs. For connected cubic bipartite graphs with n nodes, we improve on recent results of Karp and Ravi by giving a “local improvement” algorithm that finds a tour of length at most $$5/4n-2$$ . For 2-connected cubic graphs, we show that the techniques of Momke and Svensson can be combined with the techniques of Correa, Larre and Soto, to obtain a tour of length at most $$(4/3-1/8754)n$$ .
Designing for Knowledge Integration: The Impact of Instructional Time:

Science educators face constant tradeoffs between allocating time to important topics and including more topics in the curriculum. We study 3,000 students experiencing 4 increasingly streamlined ve...
Monetary Policy Uncertainty and Economic Fluctuations

Uncertainty associated with the monetary policy transmission mechanism is a key driving force of business cycles. To investigate this link, we propose a new term structure model that allows the volatility of the yield curve to interact with macroeconomic indicators. The data favors a model with two volatility factors, that capture shortterm and long-term monetary policy uncertainty. Increases in either of them lead higher unemployment rates, but they interact with ination in opposite directions.
Costs of Inefficient Regulation: Evidence from the Bakken

Abstract Efficient pollution regulation equalizes marginal abatement costs across sources. We study a new flaring regulation in North Dakota and document its efficiency. We attribute most of the observed flaring reductions at new wells in the state since late 2014 to the regulation. We construct firm-specific marginal abatement cost curves and find that the same quantity of flaring reductions could have been achieved at 44% lower cost by taxing flared gas instead of imposing firm-specific requirements. Taxing flared gas at the existing public lands royalty rate would achieve 99% of the flaring reductions at 46% lower cost.
Salinity Trends within the Upper Layers of the Subpolar North Atlantic

AbstractExamination of a range of salinity products collectively suggests widespread freshening of the North Atlantic from the mid-2000s to the present. Monthly salinity fields reveal negative trends that differ in magnitude and significance between western and eastern regions of the North Atlantic. These differences can be attributed to the large negative interannual excursions in salinity in the western subpolar gyre and the Labrador Sea, which are not apparent in the central or eastern subpolar gyre. This study demonstrates that temporal trends in salinity in the northwest (including the Labrador Sea) are subject to mechanisms that are distinct from those responsible for the salinity trends in the central and eastern North Atlantic. In the western subpolar gyre a negative correlation between near-surface salinity and the circulation strength of the subpolar gyre suggests that negative salinity anomalies are connected to an intensification of the subpolar gyre, which is causing increased flux of freshwa...
Optimizing Finance for Development

The World Bank Group recently adopted the "cascade framework" to "maximize finance for development." The cascade recommends that reforms be tried first, followed by subsidies, and then public investments. To understand the economics of the cascade, this paper presents a model where reforms, subsidies, and public investments can be used to fill the investment gap, and computes the welfare associated with their different sequencing. The cascade is optimal when reforms increase efficiency at no cost. When they are costly, if policies can be project specific, their sequencing does not matter; if not, the cascade can be optimal if agents are myopic, but not if they are forward-looking. Tensions may thus arise between maximizing private financing and optimizing financing for development.
Aortic Graft Infection Secondary to Iatrogenic Transcolonic Graft Malposition.

Aortic graft infections are a rare but devastating complication of aortic revascularization. Often infections occur due to contamination at the time of surgery. Iatrogenic misplacement of the limbs of an aortobifemoral graft is exceedingly rare, and principles of evaluation and treatment are not well defined. We report 2 cases of aortobifemoral bypass graft malposition through the colon. Case report Case 1 is a 54-year-old male who underwent aortobifemoral bypass grafting for acute limb ischemia. He had previously undergone a partial sigmoid colectomy for diverticulitis. Approximately 6 months after vascular surgery, he presented with an occult graft infection. Preoperative imaging and intraoperative findings were consistent with graft placement through the sigmoid colon. Case 2 is a 60-year-old male who underwent aortobifemoral bypass grafting due to a nonhealing wound after toe amputation. His postoperative course was complicated by pneumonia, bacteremia thought to be secondary to the pneumonia, general malaise, and persistent fevers. Approximately 10 weeks after the vascular surgery, he presented with imaging and intraoperative findings of graft malposition through the cecum. Conclusions Aortic graft infection is usually caused by surgical contamination and presents as an indolent infection. Case 1 presented as such; Case 2 presented more acutely. Both grafts were iatrogenically misplaced through the colon at the index operation. The patients underwent extra-anatomic bypass and graft explantation and subsequently recovered.
Equal treatment without large numbers

We provide a necessary and sufficient condition under which core allocations of arbitrary TU-games treat substitute players equally. The core satisfies the equal treatment property if and only if no player needs the participation of all of her substitutes to attain her core payoffs. We show how, without the requirement of a large number of players, this condition generalizes and unifies other sufficient conditions proposed in the literature (in the context of large games and economies) and it helps derive new results for particular classes of games.
Hitchhiking in space: Ancestry in adapting, spatially extended populations*

Selective sweeps reduce neutral genetic diversity. In sexual populations, this "hitchhiking" effect is thought to be limited to the local genomic region of the sweeping allele. While this is true in panmictic populations, we find that in spatially extended populations the combined effects of many unlinked sweeps can affect patterns of ancestry (and therefore neutral genetic diversity) across the whole genome. Even low rates of sweeps can be enough to skew the spatial locations of ancestors such that neutral mutations that occur in an individual living outside a small region in the center of the range have virtually no chance of fixing in the population. The fact that nearly all ancestry rapidly traces back to a small spatial region also means that relatedness between individuals falls off very slowly as a function of the spatial distance between them.
Axiomatizing causal reasoning

Causal models defined in terms of a collection of equations, as defined by Pearl, are axiomatized here. Axiomatizations are provided for three successively more general classes of causal models: (1) the class of recursive theories (those without feedback), (2) the class of theories where the solutions to the equations are unique, (3) arbitrary theories (where the equations may not have solutions and, if they do, they are not necessarily unique). It is shown that to reason about causality in the most general third class, we must extend the language used by Galles and Pearl (1997, 1998). In addition, the complexity of the decision procedures is characterized for all the languages and classes of models considered.
Self-stigma in PTSD: Prevalence and correlates

Abstract Self-stigma is the internalization of negative societal stereotypes about those with mental illnesses. While self-stigma has been carefully characterized in severe mental disorders, like schizophrenia, the field has yet to examine the prevalence and correlates of self-stigma in post-traumatic stress disorder (PTSD). Thus, we assessed self-stigma in veterans diagnosed with PTSD and compared with veterans with schizophrenia. We further examined associations between PTSD, depressive symptoms and self-stigma in the PTSD sample. Data came from two larger studies of people with PTSD (n = 46) and schizophrenia-spectrum disorders (n = 82). All participants completed the Internalized Stigma of Mental Illness Scale (ISMIS). Results revealed that people with schizophrenia report more experiences of discrimination as a result of stigma than do those with PTSD, but these diagnostic groups did not differ for other subscales. In the PTSD group, feelings of alienation positively correlated with PTSD and depressive symptoms; other subscales positively correlated with depressive symptoms only. Taken together, results suggest a significant level of self-stigma exists among veterans with PTSD, and that self-stigma has an effect on PTSD and commonly comorbid symptoms, like depression. Future work should investigate whether current self-stigma interventions for other groups could be applicable for those with PTSD.
Integrating Local Context and Global Cohesiveness for Open Information Extraction

Extracting entities and their relations from text is an important task for understanding massive text corpora. Open information extraction (IE) systems mine relation tuples (i.e., entity arguments and a predicate string to describe their relation) from sentences. These relation tuples are not confined to a predefined schema for the relations of interests. However, current Open IE systems focus on modeling local context information in a sentence to extract relation tuples, while ignoring the fact that global statistics in a large corpus can be collectively leveraged to identify high-quality sentence-level extractions. In this paper, we propose a novel Open IE system, called ReMine, which integrates local context signals and global structural signals in a unified, distant-supervision framework. Leveraging facts from external knowledge bases as supervision, the new system can be applied to many different domains to facilitate sentence-level tuple extractions using corpus-level statistics. Our system operates by solving a joint optimization problem to unify (1) segmenting entity/relation phrases in individual sentences based on local context; and (2) measuring the quality of tuples extracted from individual sentences with a translating-based objective. Learning the two subtasks jointly helps correct errors produced in each subtask so that they can mutually enhance each other. Experiments on two real-world corpora from different domains demonstrate the effectiveness, generality, and robustness of ReMine when compared to state-of-the-art open IE systems.
An Investigation of Stock Price Declines Following Corporate Financing Events: Further Evidence

Prior research documents a large downward drift in stock prices following issuances of debt and equity by US firms. We conduct tests based on both stock price and trading volume to provide evidence...
Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1

The Mre11-Rad50-Nbs1 (MRN) protein complex and ATM/Tel1 kinase protect genome integrity through their functions in DNA double-strand break (DSB) repair, checkpoint signaling, and telomere maintenance. Nbs1 has a conserved C-terminal motif that binds ATM/Tel1, but the full extent and significance of ATM/Tel1 interactions with MRN are unknown. Here, we show that Tel1 overexpression bypasses the requirement for Nbs1 in DNA damage signaling and telomere maintenance. These activities require Mre11-Rad50, which localizes to DSBs and bind Tel1 in the absence of Nbs1. Fusion of the Tel1-binding motif of Nbs1 to Mre11 is sufficient to restore Tel1 signaling in nbs1Δ cells. Tel1 overexpression does not restore Tel1 signaling in cells carrying the rad50-I1192W mutation, which impairs the ability of Mre11-Rad50 to form the ATP-bound closed conformation. From these findings, we propose that Tel1 has a high-affinity interaction with the C-terminus of Nbs1 and a low-affinity association with Mre11-Rad50, which together accomplish efficient localization and activation of Tel1 at DSBs and telomeres.
Private Anonymous Data Access

We consider a scenario where a server holds a huge database that it wants to make accessible to a large group of clients. After an initial setup phase, clients should be able to read arbitrary locations in the database while maintaining privacy (the server does not learn which locations are being read) and anonymity (the server does not learn which client is performing each read). This should hold even if the server colludes with a subset of the clients. Moreover, the run-time of both the server and the client during each read operation should be low, ideally only poly-logarithmic in the size of the database and the number of clients. We call this notion Private Anonymous Data Access (PANDA). PANDA simultaneously combines aspects of Private Information Retrieval (PIR) and Oblivious RAM (ORAM). PIR has no initial setup, and allows anybody to privately and anonymously access a public database, but the server’s run-time is linear in the data size. On the other hand, ORAM achieves poly-logarithmic server run-time, but requires an initial setup after which only a single client with a secret key can access the database. The goal of PANDA is to get the best of both worlds: allow many clients to privately and anonymously access the database as in PIR, while having an efficient server as in ORAM.
Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development

Genome-wide analysis of transcription in the malaria parasite Plasmodium falciparum has revealed robust variation in steady-state mRNA abundance throughout the 48-h intraerythrocytic developmental cycle (IDC), suggesting that this process is highly dynamic and tightly regulated. Here, we utilize rapid 4-thiouracil (4-TU) incorporation via pyrimidine salvage to specifically label, capture, and quantify newly-synthesized RNA transcripts at every hour throughout the IDC. This high-resolution global analysis of the transcriptome captures the timing and rate of transcription for each newly synthesized mRNA in vivo, revealing active transcription throughout all IDC stages. Using a statistical model to predict the mRNA dynamics contributing to the total mRNA abundance at each timepoint, we find varying degrees of transcription and stabilization for each mRNA corresponding to developmental transitions. Finally, our results provide new insight into co-regulation of mRNAs throughout the IDC through regulatory DNA sequence motifs, thereby expanding our understanding of P. falciparum mRNA dynamics.
Identification and adaptive control of a high-contrast focal plane wavefront correction system

All coronagraphic instruments for exoplanet high-contrast imaging need wavefront correction systems to reject optical aberrations and create sufficiently dark holes. Since the most efficient wavefront correction algorithms (controllers and estimators) are usually model-based, the modeling accuracy of the system influences the ultimate wavefront correction performance. Currently, wavefront correction systems are typically approximated as linear systems using Fourier optics. However, the Fourier optics model is usually biased due to inaccuracies in the layout measurements, the imperfect diagnoses of inherent optical aberrations, and a lack of knowledge of the deformable mirrors (actuator gains and influence functions). Moreover, the telescope optical system varies over time because of instrument instabilities and environmental effects. We present an expectation–maximization (E-M) approach for identifying and real-time adapting the linear telescope model from data. By iterating between the E-step (a Kalman filter and a Rauch smoother) and the M-step (analytical or gradient-based optimization), the algorithm is able to recover the system even if the model depends on the electric fields, which are unmeasurable hidden variables. Simulations and experiments in Princeton’s High Contrast Imaging Lab demonstrate that this algorithm improves the model accuracy and increases the efficiency and speed of the wavefront correction.
Review: Self-help interventions alone minimally increase smoking cessation

Source Citation Lancaster T, Stead LF. Self-help interventions for smoking cessation. Cochrane Review, latest version 26 Aug 1998. In: The Cochrane Library. Oxford: Update Software.
Exchange rates, oil prices and world stock returns

Abstract This paper examines responses of 14 major currency/USD pairs to two global factors (oil and world equity returns) from January 1999 to July 2017, a period comprising the global financial crisis and oil price boom and collapse. With global equity markets advancing, risk tolerance increases and oil and stock markets impact currencies under two methodologies: transmission of shocks and mean-variance approaches. Vector autoregressions (VARs) suggest large and statistically significant responses: commodity currencies strongly appreciate following positive oil price shocks and depreciate with positive global equity shocks. GARCH models provide similar qualitative results with coefficients typically larger for global equity returns than for oil returns. Emerging market currencies and subsamples for the crisis period are also discussed.
How To Be a Leader: A Course for Residents.

Background: Physicians are required to assume a leadership role as part of their career. For most, this is not an innate characteristic and must be developed throughout their medical training. There are few residency courses designed to assist in the enhancement of these leadership skills. We created and implemented a novel course on leadership, utilizing weekly presentations designed to stimulate discussions and improve the leadership qualities of trainees. Methods: Senior residents provided leadership lectures stimulated by assigned readings from the book "The Founding Fathers on Leadership." The traits and characteristics demonstrated throughout course readings and discussions were subsequently incorporated into everyday resident activities. Baseline and post-course survey responses were evaluated to assess changes in leadership qualities. Results: Seven senior (postgraduate year (PGY) 3-5) participated as course leaders. All seven filled out pre- and post-course surveys. Seventeen junior residents (PGY 1-2) were involved as audience members. Significant pre- and post-course differences were noted in the following areas: feelings of increased encouragement of personal development (4.86 vs. 5.43, p=0.03); increased team participation in decision-making (4.00 vs. 4.57, p=0.03); increased ease of obtaining answers to difficult questions (4.57 vs. 5.23, p=0.047); increased team member work (4.86 vs. 5.71, p=0.047), and a sense of leading a more balanced life (3.86 vs. 4.43, p=0.03). Conclusion: The initiation of a novel leadership course for senior surgical residents led to an enjoyable experience, resulting in enhanced leadership skills for all participants. We believe this process resulted in a more cohesive, efficient, communicative, and supportive residency program.
Leveraging continuous material averaging for inverse electromagnetic design.

Inverse electromagnetic design has emerged as a way of efficiently designing active and passive electromagnetic devices. This maturing strategy involves optimizing the shape or topology of a device in order to improve a figure of merit–a process which typically requires that we compute the gradient of a figure of merit which describes device performance, potentially with respect to many design variables. In this paper, we introduce a new strategy based on smoothing abrupt material interfaces which enables us to efficiently compute these gradients with high accuracy irrespective of the resolution of the underlying simulation. This has advantages over previous approaches to shape and topology optimization in nanophotonics which are either prone to gradient errors or place important constraints on the shape of the device. As a demonstration of this new strategy, we optimize a non-adiabatic waveguide taper between a narrow and wide waveguide. This optimization leads to a non-intuitive design with a very low insertion loss of only 0.041 dB at 1550 nm.