cssi/SciSciGPT-SciSciNet huggingface dataset:
Drug–drug interaction between bosutinib and warfarin

Bosutinib (SKI-606) is an orally bioavailable tyrosine kinase inhibitor (TKI) with potent activity against Src and Abl kinases, but not c-kit or platelet derived growth factor receptor kinases [1]. Bosutinib was recently approved for the treatment of chronic, accelerated or blast phase Philadelphia chromosome-positive (Ph ) chronic myelogenous leukemia (CML) with resistance or intolerance to prior therapy [2]. Here we describe a case illustrating potential drug – drug interaction between bosutinib and warfarin that led to clinically signifi cant bleeding in a patient with CML. Th e patient was an 84-year-old Caucasian male who was initially diagnosed with chronic lymphocytic leukemia (CLL) 20 years ago; the patient was asymptomatic with Rai stage 0 disease; disease risk stratifi cation based on interphase fl uorescence in situ hybridization (FISH) revealed a sole del(13q) abnormality. He was managed expectantly with observation only. Approximately 12 years after the CLL diagnosis, he presented with fatigue and decreased appetite. His physical examination showed lymphadenopathy and splenomegaly. Complete blood count showed hemoglobin of 13.7 g/dL, platelet count of 353 10 9 /L and white blood cell count of 123.7 10 9 /L, with 36% neutrophils, 28% lymphocytes, 17% monocytes and 5% basophils, suggestive of an evolving myeloid malignancy. Peripheral blood FISH revealed the BCR – ABL1 fusion in 50% of nuclei, and another 50% carried del(13q), thereby confi rming concurrent development of chronic phase CML in the background of CLL. He was treated with imatinib 400 mg daily and achieved a complete hematologic response (CHR) but subsequently lost the response. Testing at the time of relapse (approximately 18 months following treatment initiation) confi rmed the presence of BCR – ABL1 p190 transcript by reverse transcription polymerase chain reaction (RT-PCR) and the M244V mutation on kinase domain sequencing. Th e patient was thereafter treated with dasatinib and again achieved a CHR, however had signifi cant problems with drug-induced cytopenias and recurrent pleural eff usions, requiring temporary discontinuation of drug and sequential dose reduction from 100 mg to 70 mg to 25 mg daily to 25 mg every other day. Ultimately, dasatinib was permanently discontinued due to recurrent and treatmentrefractory pleural eff usions, approximately 24 months after initiation. Th e patient had hematological relapse after dasatinib discontinuation; the third TKI he received was nilotinib, initially at the dose of 300 mg twice daily. He rapidly achieved CHR but required dose reduction following temporary drug hold for grade 4 thrombocytopenia. Eventually, he was managed at a dose of 150 mg daily alternating with 150 mg twice daily for 2 years. Th e treatment was discontinued due to the development of accelerated atherosclerosis with peripheral arterial occlusive disease, with bilateral ischemic leg ulcers and gangrene of the left toes. Th e patient required left peroneal angioplasty in addition to other conservative treatment measures.
Exhaustive search for small fully absorbing sets and the corresponding low error-floor decoder

This work provides an exhaustive search algorithm for finding small fully absorbing sets (FASs) of arbitrary low-density parity-check (LDPC) codes. In particular, given any LDPC code, the problem of finding all FASs of size less than t is formulated as an integer programming problem, for which a new branch-&-bound algorithm is devised. New node selection and the tree-trimming mechanisms are designed to further enhance the efficiency of the algorithm. The proposed algorithm is capable of finding all FASs of size ≤ 11 with no larger than 2 induced odd-degree check nodes for LDPC codes of length ≤ 1000. The resulting exhaustive list of small FASs is then used to devise a new post-processing decoder. Numerical results show that by taking advantage of the exhaustive list of small FASs, the proposed decoder significantly lowers the error floor for codes of practical lengths and outperforms the state-of-the-art low-error-floor decoders.
Three-dimensional target-locking microscopy

Three-dimensional target-locking microscopy (3D-TLM) is developed to observe the dynamics of fast moving nanoscale particles with high temporal (10 μsec) and spatial (10 nm) definitions while simultaneously imaging the 3D biological environment.
Massive pulmonary embolism: a remarkable case and review of treatment

Although the clinical syndrome following pulmonary embolism (PE) may be subtle, in the case of massive PE the severity of the clinical presentation typically makes the picture more obvious. If more than two lobar pulmonary arteries become obstructed, the hemodynamic and respiratory consequences are severe, and may be life threatening. We present an unusual case where a patient experienced transient hemodynamic collapse during valsalva, and a massive saddle pulmonary embolus was discovered incidentally. Current treatment options for massive PE are then discussed.
Blocked sexual receptivity in grouped female golden hamsters, the result of contact induced inhibition.

Female hamsters maintained in groups show normal estrous cyclicity, but a significant number fail to exhibit normal mating behavior (blocked lordosis). Three experiments examined the influence of exteroceptive stimuli on this block to female sexual receptivity. Two experiments tested the possibility that a pheromonal mechanism is responsible for the behavioral block. Forty-two singly caged hamsters received either olfactory bulbectomies or sham operations. The hamsters were then grouped. Anosmic and intact hamsters equally showed the blocked lordosis. Thirteen blocked hamsters received either bilateral olfactory bulbectomies or sham operations. None of the blocked hamsters returned to lordosis. These experiments provide strong evidence against an olfactory-mediated mechanism for the block to female receptivity. The third experiment examined the hypothesis that the block to sexual receptivity is mediated by contact behaviors. Using our standard group living cage, 46 X 30 X 25 cm, 6 hamsters had access to the entire cage or were confined by wire mesh partitions to cubicles, each one sixth of the total cage volume (23 X 10 X 25 cm). Twelve hamsters were placed in grouped conditions while 30 were placed in partitioned compartments. While one third of the grouped animals displayed blocked lordosis, none of the compartmentalized hamsters was blocked. When the compartmentalized hamsters were grouped, 27% failed to exhibit lordosis. Thus contact behaviors are involved in mediating the block in lordosis found when female hamsters are maintained under group living conditions.
Using Service Patterns to Achieve Web Service Composition

In this paper, we present a pattern-based approach to support web service compositions. The concept of service patterns is designed to overcome the challenges posed by the lack of systematic ways of reusing previous experience in service interactions. A service pattern represents a class of concrete services or a generalized workflow. Hence, service patterns form an abstraction layer over concrete services and workflows. Although the concept of service patterns is independent of implementations, we formulate a way of using OWL-S mechanisms to implement service patterns. In addition, two functional operators are defined over service patterns to provide functional capabilities to operate on service patterns and facilitate automated service compositions.
Phylogeography and conservation genetics of the hellbender salamander (Cryptobranchus alleganiensis)

We investigated hellbender phylogeography through phylogenetic analyses of individuals sampled from 16 locations throughout their range in the eastern United States. Analyses were conducted on concatenated cytochrome-oxidase I (COI), cytochrome-b (Cytb) and NADH dehydrogenase subunit 4 (ND4) mtDNA sequence, totaling 2160 nucleotides. Hellbender haplotypes differed by 0.1 to 5.8% maximum likelihood (ML) corrected sequence divergence. Phylogenetic analyses reveal that hellbenders are separated into 8 reciprocally monophyletic populations or clades differentiated by a minimum of 0.7 to 5.4% sequence divergence, each of which constitutes a separate Management Unit (MU). High among population divergence and reciprocal monophyly suggest that female-mediated gene flow is severely restricted or non-existent among each MU. Hellbenders are currently divided into two subspecies, Cryptobranchus alleganiensis alleganiensis and C. a. bishopi based on morphological characters. The phylogenetic analyses presented here strongly indicate that these subspecies are paraphyletic. Management priorities for the hellbender should be reconsidered in light of these new molecular data. Results from Bayesian rooting indicate the root of the hellbender mtDNA tree lies on the branch leading to hellbender haplotypes from the Current, Eleven Point and New Rivers. The rooted tree suggests that a common ancestor in the southern Ozarks and/or southern Appalachians gave rise to northern hellbender populations, consistent with a Pleistocene refuge hypothesis.
Compromising Positions Unmarried Men, Heterosexuality, and Two-phase Masculinity

Single men are theoretically free to pursue as many sexual partners as they like, but for adult single men maturity requires that they do not. This article makes explicit that displays of heterosex...
Some Designs of Full Rate Space–Time Codes With Nonvanishing Determinant

In this correspondence, we first present a transformation technique to improve the normalized diversity product for a full rate algebraic space-time block code (STBC) by balancing the signal mean powers at different transmit antennas. After rewriting a cyclic division algebra structure into a multilayer structure for a full rate code, we show that the normalized diversity product of the transformed code with the multilayer structure is better than the one of the transformed code with the cyclic division algebra structure. We then present a new full rate algebraic STBC with multilayer structure with nonvanishing determinant (NVD) for three transmit antennas when signal constellation is carved from QAM. We show that the new code has larger normalized diversity product than the existing 3 times 3 NVD full rate STBC for quadrature amplitude modulation (QAM) signals, and we also show that it has the largest normalized diversity product in a family of full rate STBC.
Age Differences in Responses to Conflict in the Workplace

Socioemotional selectivity theory (SST) has been used successfully to explain age differences in interpersonal conflict behavior: older adults are generally less likely to engage in destructive responses, and more likely to employ nonconfrontational ones. However, this research has focused almost exclusively on conflict with intimates (spouses, family, friends), and has typically not examined conflict in the workplace. The present investigation uses behavior ratings made by bosses, peers, and subordinates of 2513 working adults to examine the association between age and workplace conflict behavior; more specifically, it tests three hypotheses generated from socioemotional selectivity theory. Consistent with predictions, raters generally agreed that older working adults were more likely to engage in nonconfrontational responses (yielding, delaying responding); also as expected, older and younger respondents did not consistently differ in their efforts to constructively solve conflict. Unexpectedly, little evidence was found that older adults engage in less active destructive behavior.
Black hole entropy in canonical quantum gravity and superstring theory

In this paper the entropy of an eternal Schwarzschild black hole is studied in the limit of an infinite black hole mass. The problem is addressed from the point of view of both canonical quantum gravity and superstring theory. The entropy per unit area of a free scalar field propagating in a fixed black hole background is shown to be quadratically divergent near the horizon. It is shown that such quantum corrections to the entropy per unit area are equivalent to the quantum corrections to the gravitational coupling. Unlike field theory, superstring theory provides a set of identifiable configurations which give rise to the classical contribution to the entropy per unit area. These configurations can be understood as open superstrings with both ends attached to the horizon. The entropy per unit area is shown to be finite to all orders in superstring perturbation theory. The importance of these conclusions to the resolution of the problem of black hole information loss is reiterated.
Immunogenicity of somatic mutations in human gastrointestinal cancers

It is unknown whether the human immune system frequently mounts a T cell response against mutations expressed by common epithelial cancers. Using a next-generation sequencing approach combined with high-throughput immunologic screening, we demonstrated that tumor-infiltrating lymphocytes (TILs) from 9 out of 10 patients with metastatic gastrointestinal cancers contained CD4(+) and/or CD8(+) T cells that recognized one to three neo-epitopes derived from somatic mutations expressed by the patient's own tumor. There were no immunogenic epitopes shared between these patients. However, we identified in one patient a human leukocyte antigen-C*08:02-restricted T cell receptor from CD8(+) TILs that targeted the KRAS(G12D) hotspot driver mutation found in many human cancers. Thus, a high frequency of patients with common gastrointestinal cancers harbor immunogenic mutations that can potentially be exploited for the development of highly personalized immunotherapies.
Preparing students for ubiquitous parallelism

Current trends in microprocessor design are fundamentally changing the way that performance is extracted from computer systems. The previous programming model for sequential uniprocessor execution is being replaced quickly with a need to write software for tightly-coupled shared memory multiprocessor systems. Both academicians and business leaders have challenged programmers to update their skill sets and their tools to effectively tackle software development for these newer platforms [1].
Hatha yoga practice for type 2 diabetes mellitus patients: a pilot study.

Objective This study was conducted to examine the impact of Hatha yoga on glycemic control, psychological and physiological stress, and self-care for individuals with type 2 diabetes mellitus (T2DM). Methods Ten sedentary individuals with T2DM who were non-insulin dependent, free of diabetes-related complications, and had no previous yoga experience completed therapeutic yoga classes for 6 weeks, 3 times per week . Glycemic control measures included fasting blood glucose, glycated hemoglobin, and fasting insulin. The State-Trait Anxiety Inventory, Perceived Stress Scale, and salivary cortisol were used to assess levels of stress, and the Summary of Diabetes Self-care Activities questionnaire was used to assess regimen adherence. Results No significant changes in glucose control or physiological stress were found; however, significant changes in perceived stress, state anxiety, and self-care behaviors were detected. Conclusions Preliminary findings support further investigation of the benefits of Hatha yoga as a complementary therapy for those with T2DM.
On the adaptation of dynamic walking to persistent external forcing using hybrid zero dynamics control

This paper investigates the ability of dynamically walking bipeds to adapt their motion to persistent exogenous forcing. Applications that involve physical interactions between a bipedal robot and other robots (or humans), require that the robot adjust its stepping pattern in response to externally applied force signals. In our setting, an underactuated bipedal robot model walks under the influence of an external force. First, the hybrid zero dynamics method is used to design controllers that stabilize periodic walking motions in the absence of the external force. Then, conditions are derived analytically under which these (unforced) periodic gaits are modified to new (possibly aperiodic) stepping patterns that are consistent with the external force. It is deduced that underactuation holds the key to the ability of our model to adapt to external forces.
Video Feedback in Philosophy

Marginal comments on student essays are a near-universal method of providing feedback in philosophy. Widespread as the practice is, however, it has well-known drawbacks. Commenting on students' work in the form of a video has the potential to improve the feedback experience for both instructors and students. The advantages of video feedback can be seen by examining it from both the professor's and the student's perspective. In discussing the professor's perspective, this article shares observations based on the author's experience delivering feedback through video. Turning to the student's view, it discusses qualitative feedback solicited from students that indicates a clear preference for video feedback over written marginalia. In particular, students describe video feedback as more informative, more personal, better at suggesting improvements on future assignments, enhancing the professor's ability to communicate through tone of voice and gesture, and easier to understand compared to written feedback.
Reply: Proportionality, Divisibility, and Economies of Scale: Two Comments

Критические замечания А.Н. Мак-Леода (A.N. McLeod) и Ф.Х. Хана (F.H. Hahn) на статью Чемберлина и ответы на них самого Чемберлина. Предмет дискуссии - взаимосвязь пропорциональности и делимости факторов производства и масштабов производства.
Projecting the Growth and Economic Impact of the Internet of Things

The next big wave of data-driven technological innovation will connect physical devices embedded with tiny computing devices to the Internet in an effort to seamlessly improve the measurements, communications, flexibility, and customization of our daily needs and activities. This “Internet of Things” (IoT) is already growing at a breakneck pace and is expected to continue to accelerate rapidly.This paper provides a brief explanation of IoT technologies before describing the current projections of the economic and technological impacts that IoT could have on society. In addition to creating massive gains for consumers, IoT is projected to provide dramatic improvements in manufacturing, health care, energy, transportation, retail services, government, and general economic growth.
Using DNA devices to track anticancer drug activity.

It is beneficial to develop systems that reproduce complex reactions of biological systems while maintaining control over specific factors involved in such processes. We demonstrated a DNA device for following the repair of DNA damage produced by a redox-cycling anticancer drug, beta-lapachone (β-lap). These chips supported s-lap-induced biological redox cycle and tracked subsequent DNA damage repair activity with redox-modified DNA monolayers on gold. We observed drug-specific changes in square wave voltammetry from these chips at therapeutic s-lap concentrations of high statistical significance over drug-free control. We also demonstrated a high correlation of this change with the specific s-lap-induced redox cycle using rational controls. The concentration dependence of s-lap revealed significant signal changes at levels of high clinical significance as well as sensitivity to sub-lethal levels of s-lap. Catalase, an enzyme decomposing peroxide, was found to suppress DNA damage at a NQO1/catalase ratio found in healthy cells, but was clearly overcome at a higher NQO1/catalase ratio consistent with cancer cells. We found that it was necessary to reproduce key features of the cellular environment to observe this activity. Thus, this chip-based platform enabled tracking of s-lap-induced DNA damage repair when biological criteria were met, providing a unique synthetic platform for uncovering activity normally confined to inside cells.
Curriculum Design to Promote the Ethical Decision-Making Competence of Accelerated Bachelor’s Degree Nursing Students:

Few nursing curricula offer a course dedicated exclusively to ethical decision making. More often, ethical decision making is integrated into nursing courses and clinical experiences along with oth...
A Comparison of Bat Activity in a Managed Central Hardwood Forest

Bats exploit forest resources based on species-specific adaptations, resulting in differences in activity across forested landscapes. Forest management practices alter forests, impacting species differently and presumably affecting bat activity. Application of forest management that promotes species-specific bat conservation requires further understanding of bat response to silvicultural practices. We surveyed timber harvest treatments on two Indiana State Forests to compare bat activity across forest management treatments, in forests adjacent to harvests, and at locations across the harvest-forest gradient from May to July in 2013 and 2014. We used Wildlife Acoustics Song Meter SM2BAT+ detectors and Kaleidoscope Pro analysis software to survey bats in relation to four treatment types: clear cut, patch cut, shelterwood preparatory cut, and intact forest. Detectors were deployed at two points within each treatment and three points on the forested periphery of treatments and recorded for three consecutive nights. We examined bat activity using N-mixture models that estimate abundance and probability of detection for an open population and used Akaike's Information Criterion to select the best models. Based on identification of acoustic calls, eastern red bats and hoary bats were more active in harvest treatments than control treatments. Big brown, eastern red, and tri-colored bats were most active at harvest edges. Northern long-eared and Indiana/little brown bats were most active at harvest edges and in adjacent forest and hoary bats were most active at harvest centers. Differences in bat activity across these managed forests suggest bat assemblages benefit from management that employs an array of silvicultural methods, provides edge habitat, and maintains adjacent forest stands. Our results can be used to predict effects of forest management practices on species-specific bat activity to maximize bat usage of forests.
Lex Mercatoria: An Arbitrator's View

in going through the surprisingly large literature on the topic of lex mercatoria and international arbitration, I was struck most by a comment by Mr. Justice Rogers of the Supreme Court of New South Wales. In discussing the debates surrounding the adoption of the UNCITRAL Model Arbitration Law,1 the judge refers to the ‘clash in philosophy … between the civil law countries and the United States, on the one hand, and the common law countries on the other …’2 I have for some time thought that in their attitude to litigation, the United States and France have more in common than the United States and England, or say, France and Germany;3 I had not thought that England's devotion to law and the former colonies' and dominions' devotion to the mother country's law were so passionate as to read the United States out of the common law world. In fact, the issue that Mr. Justice Rogers described as dividing the delegates to the UNCITRAL Conference was not precisely the issue on which we focus here, but it is closely related. The English view – notwithstanding its rather grudging, market-driven relaxation of review of arbitration in international cases4 — on the whole is founded on the belief in judicial supervision of the work of arbitrators, whereas the American and majority continental view, at least among the arbitration community, is that if parties to a contract have agreed to submit their disputes to arbitration, the decision of the arbitrators ought to be final, subject to challenge only for misconduct of the arbitrators or (possibly) excess of jurisdiction by the arbitral tribunal.5 The continental European and American view, if one can speak of it as such with the understanding that there is in fact a range of views,6 …
Spatial Resolution of Stratal Slice and Its Implications to Seismic Sedimentology

Application of seismic sedimentology in a case study demonstrated our ability to use a stratal slice to visually recognize a very thin depositional element far below seismic resolvable limit. This can be explained by spatial resolution, which is defined as a special resolution status in which an object is horizontally resolved but vertically detected by seismic data. Generation and interpretation of stratal slices require a new 3D strategy that goes beyond the limits of traditional principles such as single interface zero-phase doctrine and layered-medium assumption. A stratal slice normally represents seismic energy, mostly from a nearby /8 formation with sediments in the neighborhood of /8 to /4 having significant influence, and with side lobes ( /4 to ) having minor influence. Relative amplitude (non-peak/trough amplitude) is valuable in seismic sedimentology by revealing vital information about depositional history.
Smoking cessation: the physician's role.

Patients who come to see a physician are concerned about their health and are receptive to advice. Physicians need to remind patients who smoke of the many dangers of smoking, and encourage those who decide to stop through the long, difficult process of quitting.
MODELING AND SIMULATION FRAMEWORK FOR MULTI-OBJECTIVE IDENTIFICATION OF A GUIDED DESCENDING SYSTEM

The paper addresses the task of multi-objective identification of a controllable descending system. The main goal of this work is to develop an optimization framework and technique that can determine feasible and Pareto sets of the numerous uncertainties typical of a parachute-based descending system. The work employs the unique multi-objective optimization method called, the Parameter Space Investigation method. This paper illustrates an advantage of such a technique based on an example of identifying the unknown parameters of the controllable descending system that were discovered during our previous work. Furthermore, it provides a step-by-step implementation of the multi-objective identification of a mathematical model of a controllable circular parachute. The work presents the equations of motion, which are followed by the parameterization of acting aerodynamic forces and moments. It then introduces an application of a twostep parameters identification technique that employs two types of airdrop data (the controlled and uncontrolled set). The paper ends with a summary of the obtained results.
Is Pulse Oximetry Useful for Screening Neonates for Critical Congenital Heart Disease at High Altitudes

Now that pulse oximetry is used widely to screen for critical congenital heart disease, it is time to consider whether this screening method is applicable to those who live at high altitudes. Consideration of basic physical principles and reports from the literature indicate that not only is the 95 % cutoff point for arterial oxygen saturation incorrect at high altitudes, but the lower saturations are accompanied by greater variability and therefore there is the possibility of a greater percentage of false-positive screening tests at high altitudes. Because of ethnic differences in response to high altitudes, normative data will have to be collected separately in different countries and perhaps for different ethnic groups.
Effects of Anesthetic Fluid Injectates on Lesion Sizes in Cooled Radiofrequency Ablation.

STUDY DESIGN Nonrandomized trial. OBJECTIVE This is an ex vivo study using pork chops to simulate human vertebra to determine the effects of various anesthetic fluids injectates and concentrations on lesion size and shape created when using cooled radiofrequency ablation. Secondary objective is to determine the effects of various time durations of applied lesion on lesion size created. Our final objective is to determine the effects of fluid injectates on tissue temperature and impedance. SUMMARY OF BACKGROUND DATA Radiofrequency neurotomy is a therapeutic procedure involving ablation of sensory afferent nerves to the vertebral zygapophyseal joints. Larger lesions increase the likelihood the target nerve is ablated. METHODS Before cooled radiofrequency ablation, tissue was injected with either 0.9% normal saline, 1% lidocaine, 2% lidocaine, 0.25% bupivacaine, 0.5% bupivacaine, 0.75% bupivacaine, 0.2% ropivacaine, 0.5% ropivacaine, or 1% ropivacaine. Duration of cooled radiofrequency was either 45, 90, or 150 seconds. RESULTS There was no significant difference in the size of the lesion created when using different injectates and concentrations. There was no significant difference in the size of the lesion created when applying a 90 seconds duration lesion compared with a 150 seconds duration lesion. CONCLUSION Applying a 90 seconds duration lesion can be considered in clinical use for cooled radiofrequency ablation. The use of an injectate did not significantly alter the size or desired spherical shape of the lesion created, did not significantly alter the time required to create the lesion, and did not significantly lower the temperature threshold. The study is limited by the use of ex vivo tissue which does not account for the effects of tissue perfusion. The use of an injectate before cooled radiofrequency ablation can be made at the interventionalist's discretion. LEVEL OF EVIDENCE N/A.
Equipment Technology for Noninvasive Ventilation in the Pre-hospital Setting

Noninvasive ventilation (NIV) is the delivery of ventilatory support without the need for an artificial airway. NIV is provided using either positive or negative pressure. However, since the early 1980s, noninvasive positive pressure ventilation (NIPPV) has emerged as an important advance in respiratory care. In 2000, the National Association of EMS Physicians (NAEMSP) issued a position statement on pre-hospital NIPPV: “Non-invasive positive pressure ventilation is a viable pre-hospital therapeutic option for acute dyspnea” [1]. The NAEMSP position statement was based on the work of Kosowsky [2], titled “Pre-hospital use of continuous positive airway pressure (CPAP) for presumed pulmonary edema: a preliminary case series,” also published in 2000.
Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity

Interferons (IFNs) are key cytokines identified in vertebrates and evolutionary dominance of intronless IFN genes in amniotes is a signature event in IFN evolution. For the first time, we show that the emergence and expansion of intronless IFN genes is evident in amphibians, shown by 24-37 intronless IFN genes in each frog species. Amphibian IFNs represent a molecular complex more complicated than those in other vertebrate species, which revises the established model of IFN evolution to facilitate re-inspection of IFN molecular and functional diversity. We identified these intronless amphibian IFNs and their intron-containing progenitors, and functionally characterized constitutive and inductive expression and antimicrobial roles in infections caused by zoonotic pathogens, such as influenza viruses and Listeria monocytogenes. Amphibians, therefore, may serve as overlooked vectors/hosts for zoonotic pathogens, and the amphibian IFN system provides a model to study IFN evolution in molecular and functional diversity in coping with dramatic environmental changes during terrestrial adaption.
Using online games to capture, generate, and understand natural language

While the game industry has excelled at simulating combat, dynamically generating social interaction and natural language dialogue has proven intractable. The gaming landscape today, with millions of people playing games together online, provides opportunities to radically rethink our approach to developing conversational, socially intelligent characters. This talk will present a data-driven, human-machine collaborative approach to automating characters using data recorded from online human-human interactions, including a crowd-sourced annotation framework, and a new real-time planning system driven by thousands of annotated human gameplay traces. The approach will be demonstrated with examples from three novel games: The Restaurant Game has recorded over 16,000 people playing as customers and waitress, Improviso is currently recording players on the set of a low-budget science fiction movie, and Mars Escape has recorded hundreds of online human-robot interactions for eventual transfer to a real robot.
Joint-use libraries: Just how good are they?

One must consider the tremendous benefits that can be derived from one of the joint-use libraries. At the same time that operational costs are being drastically reduced for both partners, patrons are being provided with a larger and more diversified collection than could be made available by just one of the partners
Contraception Choice in Adolescence

An 18-year-old girl is a freshman in community college and has a history of focal epilepsy of left frontal origin due to cortical dysplasia. She is managed on oxcarbazepine and has remained seizure free in the past year. She informs you that she is sexually active and has been in stable relationship with her boyfriend in the past 6 months. She is asking you for advice on starting contraception. What form of contraception are you most likely to recommend to her? What will be your advice if she was on lamotrigine, topiramate, or levetiracetam?
Lignin Profiling: A Guide for Selecting Appropriate Lignins as Precursors in Biomaterials Development

A number of industrial and technical lignins from forestry and agriculture were extracted by different chemical pulping processes and characterized by evaluating their physical and chemical properties. Several qualitative and quantitative methods were performed to elucidate lignin profiles and their potentials as substitutes for use in biobased products. The morphology, molecular weight distributions, elemental compositions, glass transition temperature, and several important functional groups containing hydroxyl units such as phenolic, aliphatic, and carboxylic acid were classified and their contents were determined quantitatively by employing 31P NMR spectroscopy. The emerging information is relevant to pressing scientific development issues for value-added applications from lignins during industrial production of biomaterials.
Love, passion, and peak experience: A qualitative study on six continents

AbstractQualitative inquiry promotes deeper understanding of human experiences that can be reduced and decontextualized when examined solely via quantitative methods. In this study, we interviewed 150 people in 22 countries on six continents, asking them, ‘What do you love?’, ‘What is a great passion in your life?’, and ‘What has been a peak experience in your life?’. Love, passion, and peak experience share definitional and theoretical overlaps. However, they have not been explored simultaneously across cultures using qualitative methods. We utilized a pragmatic, inductive, thematic methodology, and 11 key themes emerged from the data. Other people and learning and growing were the top two themes for all three constructs, and data patterns suggested more variation within than between continents. We suggest that love, passion, and peak experience may promote self-determination and/or psychological complexity via integration with and differentiation from the environment, and suggest directions for future r...
GPGPU Footprint Models to Estimate per-Core Power

We explore the problem of how to easily estimate the per-core power distribution of GPGPUs from the total power of all cores. We show that the dynamic energy consumption of a core for a given kernel, represented by its work footprint , is approximately proportional to the total time taken by all work units executing on that core, and the static power, represented by its core footprint , is proportional to the time that the core has assigned work. Footprints can be easily tracked using two hardware counters per GPU core. We also show how per-core power estimates can be used to compute power-performance pareto frontiers that identify opportunities for saving power and energy in cases of non-uniform work distribution by exploiting per-core DVFS support for GPGPUs.
Joint stochastic orders of high degrees and their applications in portfolio selections

Abstract In this paper, we propose two new classes of joint stochastic orders, namely joint (reversed) hazard order of degree n and joint n -increasing convex/concave order, and establish their theoretical properties. These new orders substantially generalize the existing class of joint stochastic orders, and incorporate them in one general framework. We also explore the applications of these orders in portfolio selections and unify similar studies on this problem.
Introduction: My Personal and Scholarly Journey

Inspired by Langston Hughes’ poem “I, Too, Sing America,” Lorick-Wilmot draws parallels between the poem’s tenets and the invisibility of the black middle class second generation Caribbean immigrant (referred to as MSGCI) in contemporary conversations on race to discuss the sociological significance of the book. With a specific focus on the stories MSGCIs tell about their everyday identity performances around race, ethnicity, upward class mobility, and gender, the chapter highlights the importance of sharing and preserving these narratives, which are often marginalized from the master narrative on race and immigrant generation, and expose the multidimensionality of oppression that complicates the lives of those perceived as being upwardly mobile in their pursuit of the “American Dream.”
Time-Spectral Method for Overlapping Meshes

Overset and Cartesian solvers typically employ conventional time-marching schemes to simulate unsteady flows. Temporal pseudospectral schemes have demonstrated the ability to dramatically reduce th...
Metastatic Disease of the Thoracolumbar Spine

Metastases are the neoplasms most commonly seen by both orthopaedic and neurosurgeons, and the spine is the site most frequently involved (9,20). At autopsy, more than 70% of patients who die of cancer have vertebral metastases (23). Although nearly all malignancies may metastasize to bone, carcinoma of breast and bronchogenic origin, lymphoma, and multiple myeloma account for half of all spinal metastases (4,11,12,20,35,38,51).
Outcomes of Student-Driven, Faculty-Mentored Research and Impact on Postgraduate Training and Career Selection

Objective. To evaluate scholarly deliverables from student-driven research and explore the impact on postgraduate training placement rates, pharmacy faculty appointments and lifetime publications. Methods. A retrospective analysis of Doctor of Pharmacy graduates who conducted student research between the academic years of 2002 and 2015 was performed. Data were collected on research participation, abstracts, presentations, postgraduate training, full-time faculty appointments, and publications. Results. Of 1229 graduates, 300 participated in research during pharmacy school. Fifty-six percent (n=167) submitted at least one abstract and 68 students (23%) published their research. Research participation was associated with a significantly higher likelihood of postgraduate training and specialty training. Research participation positively affected the likelihood of faculty appointment and lifetime publication rate. Conclusion. Students who engaged in elective research had significant scholarly deliverables, including peer-reviewed publications, and were more likely to successfully match in a postgraduate position and achieve full-time academic appointments.
BiGRA: A preliminary bilateral hand grip coordination rehabilitation using home-based evaluation system for stroke patients

Motor impairment is common following stroke. Diminished strength and coordination contribute to reduced ability to perform activities of daily living. The existing healthcare models focus on delivering rehabilitation during the first few months following stroke. Yet, to regain motor control to the greatest degree, rehabilitation should continue across the lifespan. Currently, individuals with stroke are responsible for self-managing their rehabilitation once therapist guided rehabilitation has concluded. Individuals with stroke are frequently given a written home exercise program to help guide their home rehabilitation, but poor compliance demonstrates a better approach is necessary. In this study, we propose BiGRA, a novel system to more effectively facilitate in-home bilateral rehabilitation. This system holds merits in: (1) An end-to-end task-oriented system for bilateral grip control which emphasizes the modulation of grip coordination between hands; and (2) Innovative metrics framework to quantitatively analyze the motor control performance. The evaluation shows that BiGRA can objectively measure the patients' task performance and is a promising assessment tool for stroke rehabilitation.
The Role of Working Memory Capacity and Cognitive Load in Producing Lies for Autobiographical Information

This study examined effects of working memory capacity (WMC) and cognitive load on one's ability to convincingly tell lies. Recent research suggests imposing a cognitive load improves lie detection. We hypothesized that the cognitive demands of lying, particularly under high load, would lead to poorer performance among low-WMC individuals. In our study, young adults gave truthful or deceptive responses to autobiographical questions when under either high or low cognitive load. Detectors attempted to guess speaker veracity either in person or when later watching a video recording. When under high load, low-WMC individuals’ lies were more easily detected and they also had greater difficulty remembering the truth. High-WMC individuals were unaffected by load. These results suggest that imposing cognitive load during interrogations might selectively affect low-WMC individuals, allowing greater lie detection, but also creating wrongful convictions based on changing testimony over time.
Writing as if Arithmeticke: George Bickham’s Cyphering Book, Circa 1740

Of the 11 extraordinary cyphering books considered in this volume, George Bickham’s was the only one that was specifically prepared for sale to others. We do not know how many copies of this book were printed, but we do know that the copy which we now hold is one of very few which remain. Bickham was a writing master who was regarded, in his time, as one of world’s best penman. As was usually the case with writing masters, he paid much attention to the kind of writing and calligraphy needed to prepare a strikingly beautiful cyphering book, and this book provides testimony to that fact. However, there are hardly any model examples, or exercises for the student to do. The emphasis seemed to be on form rather than mathematical substance, and the language of commercial arithmetic is strongly emphasized. As would have been expected, topics are presented according to the normal abbaco sequence.
Fluctuations of the Weight Indicated by a Microbalance in the Pressure Range Between 1 and 103 torr with the Sample at a Lower Temperature than the Beam

Large fluctuations in the indicated weight of up to 0.1 Hz frequency and 50 µg amplitude, were observed when using a vacuum microbalance with suspended pans, of which one was cooled to 77 K and the balance beam kept at room temperature. The amplitudes increased with increasing pressure and temperature difference between sample and beam. In a nitrogen atmosphere, the fluctuations began at 200 torr, and in an argon atmosphere at 140 torr, while in helium and hydrogen no fluctuations were observed. When the balance pan was empty, the fluctuations were particularly large, and when loaded, they generally decreased. With horizontally suspended disks and vertical tubes, practically no fluctuations were observed.
Cyber criminology: an interdisciplinary approach in the age of cyber threat

This tutorial will introduce participants to the interdisciplinary field of cyber criminology. In this tutorial, we will share our experiences in developing and team teaching an interdisciplinary cyber criminology course. The tutorial is designed for those who are interested in learning about teaching cybercrime from the dual perspective of computer science and criminal justice. Participants will have the opportunity to participate in both a hands-on activity on how to protect themselves against cyber criminals and a group discussion concerning the balance between security and individual privacy in today's networked environment.
Risk factors for diabetes are higher among non-heterosexual US high-school students

Low physical activity (PA), high sedentary behavior (SB), and overweight and obesity have been shown to associate with increased Type 2 diabetes risk among adolescents. We investigated PA, SB, and overweight and obesity among Youth Risk Behavior Survey (YRBS) respondents to determine if non-heterosexual youth may be at increased diabetes risk compared to heterosexual youth. Weighted city and state YRBS data were pooled across 44 jurisdictions biennially from 2009 to 2015, resulting in a sample size of 350 673 students. Overall, 88.4% identified as heterosexual, 2.1% as gay or lesbian, 5.7% as bisexual, and 3.7% as unsure. With the exception of lesbian female students, after adjusting for age, race/ethnicity, body mass index, and survey year, all non-heterosexual youth reported significantly fewer days per week of PA compared to their sex-matched heterosexual counterparts. Similarly, compared to heterosexual female youth, bisexual and not sure female youth reported significantly more hours per day of SB. These PA and SB findings remained significant after adjustment for depressive symptoms and in-school bullying among bisexual female youth only. In fully adjusted models, lesbian students were 1.85 times more likely to be overweight and lesbian, bisexual, and not sure female youth were 1.55 to 2.07 times more likely to be obese than heterosexual female students. No significant differences in SB, overweight, or obesity were found among gay, bisexual, or unsure male youth compared to heterosexual male youth. Non-heterosexual youth may be at increased risk for developing type 2 diabetes mellitus compared to heterosexual youth. Future studies should characterize diabetes prevalence among non-heterosexual youth.
RemedioT: Remedial Actions for Internet-of-Things Conflicts

The increasing complexity and ubiquity of using IoT devices exacerbate the existing programming challenges in smart environments such as smart homes, smart buildings, and smart cities. Recent works have focused on detecting conflicts for the safety and utility of IoT applications, but they usually do not emphasize any means for conflict resolution other than just reporting the conflict to the application user and blocking the conflicting behavior. We propose RemedIoT, a remedial action 1 framework for resolving Internet-of-Things conflicts. The RemedIoT framework uses state of the art techniques to detect if a conflict exists in a given set of distributed IoT applications with respect to a set of policies, i.e., rules that define the allowable and restricted state-space transitions of devices. For each identified conflict, RemedIoT will suggest a set of remedial actions to the user by leveraging RemedIoT's programming abstractions. These programming abstractions enable different realizations of an IoT module while safely providing the same level of utility, e.g., if an air-conditioner application that is used to implement a cooling module conflicts with a CO2 monitor application that requires ventilation at home, a non-conflicting smart fan application will be suggested to the user. We evaluate RemedIoT on Samsung SmartThings applications and IFTTT applets and show that for 102 detected conflicts across 74 sample applications with 11 policies, RemedIoT is able to remediate ~ 80% of the conflicts found in the environment, which would normally be blocked by prior solutions. We further demonstrate the efficacy and scalability of our approach for smart city environments.
Racial inequities in U.S. naloxone prescriptions

Background: Research indicates U.S. racial and ethnic minority patients are prescribed opioids for pain less often than non-Hispanic Whites. Racial inequities are strongest for pain conditions with...