cssi/SciSciGPT-SciSciNet huggingface dataset:
Randomized controlled dissemination study of community-to-clinic navigation to promote CRC screening: Study design and implications.

Abstract Introduction Regular screening facilitates early diagnosis of colorectal cancer (CRC) and reduction of CRC morbidity and mortality. Screening rates for minorities and low-income populations remain suboptimal. Provider referral for CRC screening is one of the strongest predictors of adherence, but referrals are unlikely among those who have no clinic home (common among poor and minority populations). Methods/study design This group randomized controlled study will test the effectiveness of an evidence based tailored messaging intervention in a community-to-clinic navigation context compared to no navigation. Multicultural, underinsured individuals from community sites will be randomized (by site) to receive CRC screening education only, or education plus navigation. In Phase I, those randomized to education plus navigation will be guided to make a clinic appointment to receive a provider referral for CRC screening. Patients attending clinic appointments will continue to receive navigation until screened (Phase II) regardless of initial arm assignment. We hypothesize that those receiving education plus navigation will be more likely to attend clinic appointments (H1) and show higher rates of screening (H2) compared to those receiving education only. Phase I group assignment will be used as a control variable in analysis of screening follow-through in Phase II. Costs per screening achieved will be evaluated for each condition and the RE-AIM framework will be used to examine dissemination results. Conclusion The novelty of our study design is the translational dissemination model that will allow us to assess the real-world application of an efficacious intervention previously tested in a randomized controlled trial.
The Rise and Decline of La Yuma: Global Symbols, Local Meanings, and Remittance Circuits in Post-Soviet Cuba

Resumen Examinando las transformaciones actuales de la sociedad cubana tras la desapariciόn de la Uniόn Sovietica, este articulo explora el termino popular cubano “La Yuma,” y las mutaciones semioticas de sus mas deseados bienes, marcas y simbolos durante los ultimos veinte anos. Mi propuesta es que, en vez de apuntar simplemente a una politica contrarrevolucionaria, bienes tales como prendas de ropa con la bandera estadounidense, o tenis de la marca Nike, indican principalmente la emergencia de lo que yo llamo “circuitos de remesas” entre la Cuba post-sovietica y sus comunidades en la diaspora, en vez de denotar sencillamente una posicion politica de resistencia al estado revolucionario, tal y como se asume con frecuencia. Una mirada integradora, que busque comprender a la vez los movimientos de personas, sus marcas preferidas, y los significados locales de simbolos globales, contribuira a enriquecer etnograficamente la comprension teorica de la Cuba contemporanea en campos tales como los estudios (post) socialistas, caribenos, transnacionales, y globales, en un amplio sentido.
Abstract 4491: Modulation of p63 expression by phosphorylation of RBM38 at S195 via miR-203

p63, a p53 family protein, acts as a sequence-specific DNA-binding transcriptional factor to regulate the expression of target genes involving in various cellular processes, including growth suppression and epithelial development. RBM38, a RNA-binding protein, is a target of p53 family and is known to interact with its target mRNAs and regulate their expression via mRNA stability. Previously, we found that RBM38 negatively regulates p63 mRNA stability through binding to the AU/U-rich element in 3′ untranslated region (3′-UTR). We also found that phosphorylation of RBM38 at Ser195 alters the conformation and function of RBM38 protein. However, it is unclear whether phosphorylation of RBM38 or miR-203 alters the ability of RBM38 to regulate p63 expression. In this study, we found that in both MCF7 and HaCaT cells, wild-type RBM38 and S195A mutant, but not phosphor-mimic S195D mutant, inhibit p63 mRNA stability, suggesting that Ser195 phosphorylation abrogates the ability of RBM38 to repress the expression of p63. Importantly, we found that phosphorylation of RBM38 disrupts the binding of RBM38 to the U-rich element in p63 3′-UTR. Additionally, we found that miR-203 inhibitor increases, whereas miR203 mimic decreases p63 expression through binding to p63 3′-UTR, consistent with a previous report. Interestingly, we found that the ability of RBM38 to repress p63 expression is disrupted by miR-203 inhibitor but enhanced by miR-203 mimic. Furthermore, we found that wild-type RBM38 protein, but not phosphor-mimic S195D mutant, physically interacts with Ago2, indicating that RBM38 may inhibit p63 mRNA stability by modulating Ago2-miR-203 complex to bind to the U-rich element in p63 3′-UTR. Together, we uncovered a novel mechanism by which RBM38 modulates p63 expression via miR-203. Note: This abstract was not presented at the meeting. Citation Format: YANHONG ZHANG, WENSHENG YAN, JIN ZHANG, XINBIN CHEN. Modulation of p63 expression by phosphorylation of RBM38 at S195 via miR-203 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4491. doi:10.1158/1538-7445.AM2017-4491
Sidelobe Level and Aperture Efficiency Optimization for Tiled Aperiodic Array Antennas

Array antennas with aperiodic element placement provide a way to mitigate grating lobe level when the array element spacing is larger than one half wavelength. Design techniques for aperiodic arrays include thinning, numerical optimization, and other methods, but even with modern tools, designing electrically large aperiodic arrays remain computationally challenging. To reduce the complexity of the large aperiodic array design problem, we study the use of discrete rotated tiles with element positions and tile orientations optimized to minimize peak sidelobe level (PSLL). The directivity, frequency sensitivity of PSLL, and optimization complexity for uniform arrays, aperiodic arrays, and tiled arrays are compared. Based on many numerical examples, an approximate relationship between PSLL and array element number and density for aperiodic and tiled arrays is proposed as a convergence estimator for the design optimization process.
Sorghum panicle extraction from unmanned aerial system data

Attributes of sorghum panicle is a very important to assess overall crop condition, irrigation, and estimation of terminal yield. In this study, a novel method to extract sorghum panicle and estimate panicle volume of grain sorghum using an Unmanned Aerial System (UAS) is proposed. UAS data were acquired with 85% overlap at an altitude of 10m above ground. Ortho-mosaic image, Digital Surface Model (DSM), and 3D point cloud were generated by applying the Structure from Motion (SfM) algorithm to the images. Ground Control Points (GCP) were used for accurate geo-referencing. Sorghum panicles were determined from RGB image and DSM by using color ratio and circle fitting. Panicle volume was estimated by the cylinder fitting method and the disk stacking method. The results of this study showed that UAS data can provide non-destructive, more efficient, and may be considered to replace the field work.
Correction to: Multilateral development banking in a fragmented climate finance system: shifting priorities in energy finance at the Asian Development Bank

The article title was incorrectly published in the original publication. The correct title is given in this correction.
Recognizing and Referring Children with Posttraumatic Stress Disorder: Guidelines for Pediatric Providers.

1. Helen W. Wilson, PhD* 2. Shashank V. Joshi, MD* 1. *Division of Child and Adolescent Psychiatry and Child Development, Stanford University School of Medicine, Stanford, CA * Abbreviations: DSM-V : : Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition PTSD: : posttraumatic stress disorder SSRI: : selective serotonin reuptake inhibitors Posttraumatic stress disorder (PTSD) affects approximately 4% of US children and teens and can severely impact the quality of social, academic, and personal welfare aspects of a child or adolescent and can persist into adulthood. Yet, 1 study indicated that only 18% of pediatricians surveyed felt that they had adequate knowledge of pediatric PTSD, and most (72%) reported that greater collaboration with mental health providers would improve their assessment of PTSD. (1) Health-care providers who treat pediatric populations should be aware of the magnitude of this problem and be able to screen for and refer children and teens with PTSD for specific treatments. (1) 1. Banh MK, Saxe G, Mangione T, Horton NJ. Physician-reported practice of managing childhood posttraumatic stress in pediatric primary care. Gen Hosp Psychiatry . 2008;30(6):536–545 After completing this article, readers should be able to: 1. Identify and refer children affected by trauma for appropriate evaluation and evidence-based treatment. 2. Summarize the evidence for treatment approaches, including psychotherapies. 3. Understand the importance of pediatric providers knowing about what treatments have been supported for treating pediatric posttraumatic stress disorder. At a routine health supervision visit, a mother expresses concern that her 3-year-old daughter has “gone back to the terrible twos.” The mother says that her daughter is having intense tantrums that can last hours, is having increased difficulty separating from her, is taking much longer than usual to get to sleep at night, is often coming into her mother’s room in the middle of the night, and has wet her pants on several occasions although she was previously toilet trained. The mother says that these behaviors began shortly after an …
Refusing resilience: the racialization of risk and resilience

In this short essay debating the politics of resilience, I draw from the circulation of resilience discourses following the Milwaukee Uprising of 2016 to argue that critiques of resilience planning...
Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms

The release of free fatty acids (FFAs) from adipocytes (i.e. lipolysis) is increased in obesity and is a contributory factor to the development of insulin resistance. A recently identified adipokine, apelin, is up-regulated in states of obesity. Although apelin is secreted by adipocytes, its functions in them remain largely unknown. To determine whether apelin affects lipolysis, FFA, glycerol, and leptin levels, as well as abdominal adiposity, were measured at baseline and after reintroduction of exogenous apelin in apelin-null mice. To examine apelin's effects in vitro, isoproterenol-induced FFA/glycerol release, and hormone-sensitive lipase (HSL) and acetyl CoA carboxylase phosphorylation were investigated in 3T3-L1 cells and isolated wild-type adipocytes. Serum FFA, glycerol, and leptin concentrations, as well as abdominal adiposity, were significantly increased in apelin-null vs. wild-type mice; these changes were ameliorated in response to exogenous apelin. Apelin also reduced isoproterenol-induced FFA release in adipocytes isolated from wild-type but not APJ-null mice. In 3T3-L1 cells and isolated adipocytes, apelin attenuated isoproterenol-induced FFA/glycerol release. Apelin's inhibition was reversed by pertussis toxin, the G(q) inhibitor glycoprotein antagonist 2A, and the AMP-activated protein kinase inhibitors compound C and dorsomorphin. Apelin increased HSL phosphorylation at Ser-565 and also abrogated isoproterenol-induced HSL phosphorylation at Ser-563. Notably, apelin increased acetyl CoA carboxylase phosphorylation, suggesting AMPK activation. In conclusion, apelin negatively regulates lipolysis. Its actions may be mediated by pathways involving G(q), G(i), and AMP-activated protein kinase.
Algorithms for Visual Tracking of Visitors Under Variable-Lighting Conditions for a Responsive Audio Art Installation

For a responsive audio art installation in a skylit atrium, we developed a single-camera statistical segmentation and tracking algorithm. The algorithm combines statistical background image estimation, per-pixel Bayesian classification, and an approximate solution to the multi-target tracking problem using a bank of Kalman filters and Gale-Shapley matching. A heuristic confidence model enables selective filtering of tracks based on dynamic data. Experiments suggest that our algorithm improves recall and \(F_{2}\)-score over existing methods in OpenCV 2.1. We also find that feedback between the tracking and the segmentation systems improves recall and \(F_{2}\)-score. The system operated effectively for 5–8 h per day for 4 months. Source code and sample data is open source and available in OpenCV.
Research in Education

Research in medical education is critical for demonstrating the effectiveness of educational interventions and for identifying new methods of teaching and assessment. Education research can facilitate the careful and systematic approach to educational innovations, bridge the gap between education theory and practice, and support policy changes. Research also allows us to study new advances in science and technology in order to clarify their benefit and identify how to best use this information to facilitate learning. Taking a scholarly approach to education research allows others to determine the value of an intervention. Additionally, given that we are often tasked with improving the efficiency and effectiveness of medical education, studying the impact of teaching and learning approaches provides important data to guide such improvements.
Postcranial Morphology of Apheliscus and Haplomylus (Condylarthra, Apheliscidae): Evidence for a Paleocene Holarctic Origin of Macroscelidea

Small-bodied eutherian mammals with bunodont teeth from the Paleocene and Eocene have long been the subjects of taxonomic contention, with regard to both the assignment of individual genera to supergeneric clades (such as Hyopsodontidae, Pentacodontidae, and Dormaalidae) and to the place of those larger groups within Eutheria. Taxa traditionally placed in the family Hyopsodontidae have proven particularly problematic from the first standpoint, the clade has become a wastebasket for small-bodied, bunodont taxa whose morphology suggests affinities with the basal ungulate order Condylarthra (in this study, Ungulata and ungulate refer to the traditional morphological concept of this group, minimally including Artiodactyla, Perissodactyla, Hyracoidea, 5. Postcranial Morphology of Apheliscus and Haplomylus (Condylarthra, Apheliscidae): Evidence for a Paleocene Holarctic Origin of Macroscelidea
Invertible transducers, iteration and coordinates

We study natural computational problems associated with iterated transductions defined by a class of invertible transducers over the binary alphabet. The transduction semigroups of these automata are known to be free Abelian groups and the orbits of words can be described as affine subspaces in a suitable geometry defined by the generators of these groups. We show how to compute the associated coordinates of words in quadratic time and how to apply coordinates to the problem of deciding whether two words generate the same orbit under a given transduction. In some special cases our algorithms can be implemented on finite state machines.
Factors determining resistance and susceptibility to infection with Toxoplasma gondii

Toxoplasma gondii is an intracellular protozoan parasite that invades a variety of host cells in various organs including the central nervous system. IFN-γ-dependent, cell-mediated immunity is crucial for controlling the parasites during the acute stage of infection and for preventing development of toxoplasmic encephalitis (TE) during the later stage of infection. Multiple populations of both T and non-T cells are important sources of IFN-γ in the resistance. IL-12, IL-18, Bcl-3, NF-κB(2), and CD40-CD40L ligand interaction upregulate the IFN-γ production. Down-regulation of IFN-γ-mediated immune responses is also important for host resistance to prevent development of immunopathology caused by overly stimulated responses. IL-10. TGF-β and lipoxin A4 are involved in such down-regulation. IFN-γ-mediated immune responses control tachyzoitesin both phagocytic and non-phagocytic cells through at least five different mechanisms, most likely depending on the types of cells responding to IFN-γ. Such effector functions involve production of nitric oxide by inducible nitric oxide synthase, tryptophan degradation by indolamine 2,3-dioxygenase, unidentified IFN-γ responsive gene family, limiting the availability of intracellular iron to the parasite, and production of reactive oxygen intermediates. Host genes affect resistance/susceptibility to infection with this parasite. Genes that regulate resistance against acute infection differ from those that regulate resistance to development of TE during the late stage of infection. In mouse, at least five genes are involved in determining survival during the acute stage whereas the L d gene within the D region of the major histocompatibility (H-2) complex confers resistance to development of TE. In AIDS patients, HLA-DQ3 appears to be a genetic marker of susceptibility to development of TE, and HLA-DQ1 appears to be a resistance marker. Strains (genetic variation) of T. gondii are another factor that affects the susceptibility of the host to both acute and late stages of infection. The genotypes of the parasite are important for determining the susceptibility. Some combination of alleles at two or more loci appears to be pivotal to determine virulence of the parasite during acute stage of infection. It is possible that the genes of the host and genetic variation of T. gondii affect immune response of the host to the parasite, thereby contribute to determining resistance to the infection.
Enteral and Parenteral Nutrition

Malnutrition is more common in geriatric population because of higher incidence of chronic disability and disease, but the principles of nutritional support are the same as those for any adult. Nutrition support should be implemented in a step-wise fashion, starting with dietary consultation with a nutritionist with recommendations for dietary change or supplementation. If this fails, nasogastric feeding should be considered. In the presence of anatomic changes in the upper gastrointestinal tract, a more distal postpyloric feeding tube should be considered. Intestinal failure is the only absolute indication for parenteral feeding, but initial PN supplementation may be necessary in the critically ill depleted patient while awaiting enteral feeding (EN). In the vast majority of patients, a simple low-cost polymeric formula will meet EN requirements. Extra care should be taken in the elderly terminal patient to avoid long-term “forced feeding,” whether it be EN, PN, or via gastrostomy, as these interventions are associated with poor outcomes and may actually impair the remaining quality of life.
Roly-Poly Egg Sacs: Isopods Used as Replacement Egg Sacs by the Wolf Spider Pardosa valens (Araneae: Lycosidae)

Abstract Wolf spider females have the distinctive behaviour of carrying the egg sac attached to the spinnerets. If this egg sac is dislodged, the female will retrieve and reattach it, if possible. However, in some instances, a female may reattach another object of similar size or shape as a replacement for a lost egg sac. Here, I report the first example of an isopod, Armadillidium vulgare, being used as a substitute for a missing egg sac in Pardosa valens Barnes, 1959 from southeastern Arizona.
Thermophilic Proteins as Versatile Scaffolds for Protein Engineering

Literature from the past two decades has outlined the existence of a trade-off between protein stability and function. This trade-off creates a unique challenge for protein engineers who seek to introduce new functionality to proteins. These engineers must carefully balance the mutation-mediated creation and/or optimization of function with the destabilizing effect of those mutations. Subsequent research has shown that protein stability is positively correlated with “evolvability” or the ability to support mutations which bestow new functionality on the protein. Since the ultimate goal of protein engineering is to create and/or optimize a protein’s function, highly stable proteins are preferred as potential scaffolds for protein engineering. This review focuses on the application potential for thermophilic proteins as scaffolds for protein engineering. The relatively high inherent thermostability of these proteins grants them a great deal of mutational robustness, making them promising scaffolds for various protein engineering applications. Comparative studies on the evolvability of thermophilic and mesophilic proteins have strongly supported the argument that thermophilic proteins are more evolvable than mesophilic proteins. These findings indicate that thermophilic proteins may represent the scaffold of choice for protein engineering in the future.
Binding Number, Cycles, and Cliques

I discuss the binding number of a graph and Woodall’s conjecture that binding number at least 3∕2 implies a graph is pancyclic.
Bacterial analogs of plant piperidine alkaloids mediate microbial interactions in a rhizosphere model system

Plants expend significant resources to select and maintain rhizosphere communities that benefit their growth and protect them from pathogens. A better understanding of assembly and function of rhizosphere microbial communities will provide new avenues for improving crop production. Secretion of antibiotics is one means by which bacteria interact with neighboring microbes and sometimes change community composition. In our analysis of a taxonomically diverse consortium from the soybean rhizosphere, we found that Pseudomonas koreensis selectively inhibits growth of Flavobacterium johnsoniae and other members of the Bacteroidetes grown in soybean root exudate. A genetic screen in P. koreensis identified a previously uncharacterized biosynthetic gene cluster responsible for the inhibitory activity. The metabolites were isolated based on biological activity and were characterized using tandem-mass spectrometry, multidimensional NMR, and Mosher ester analysis, leading to the discovery of a new family of bacterial piperidine alkaloids, koreenceine A-D. Three of these metabolites are analogs of the plant alkaloid γ-coniceine. Comparative analysis of the koreenceine cluster with the γ-coniceine pathway revealed distinct polyketide synthase (PKS) routes to the defining piperidine scaffold, suggesting convergent evolution. Koreenceine-type pathways are widely distributed among Pseudomonas species, and koreenceine C was detected in another Pseudomonas sp. from a distantly related cluster. This work suggests that Pseudomonas and plants convergently evolved the ability to produce similar alkaloid metabolites that can mediate inter-bacterial competition in the rhizosphere.
Relative activation patterns associated with self-transcendent and self-enhancement core values: An fMRI study of basic human values theory concepts in males

Core values have been shown to influence a variety of social behaviors, but research on the brain networks supporting their effects is sparse. While undergoing fMRI scanning, twenty male participants evaluated descriptions of real-world activities according to how worthwhile they were and how likely they were to participate in them. Each activity was categorized according to contexts conceptualized in the Basic Human Values Theory (BHVT) model of core values. We investigated two Self-enhancement values (Power and Achievement) and two Self-transcendent values (Benevolence and Universalism). Behavioral results indicated that Achievement and Benevolence activities were rated higher on both worthiness and participation willingness than Power and Universalism activities. Neuroimaging results revealed that self-transcendence activities elicited greater medial prefrontal cortex and anterior cingulate activation relative to self-enhancement activities during participation rated trials. Contrasting Power, Benevolence, and Universalism activities against Achievement activities during participation rated trials revealed a network of regions critical for moral processing, suggesting that activities corresponding to these three values were considered within a moral framework. No brain regions demonstrated activity that tracked behavioral ratings associated with specific values. This study expands upon previous core values research by demonstrating that real-world contexts related to different BHVT values elicit different brain regions.
Nanocrystal Formulation Improves Vaginal Delivery of CSIC for HIV Prevention.

5-Chloro-3-phenylsulfonylindole-2-carboxamide (CSIC) is a highly potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with potential for use in topical prophylaxis against HIV transmission. However, the hydrophobic nature of CSIC limits its administration through vaginal route. In this study, we developed nanocrystals of CSIC to potentially improve the aqueous solubility and intracellular uptake of CSIC in vitro and in vivo. CSIC nanocrystals were manufactured and stabilized with Pluronic F98 and hydroxypropyl methylcellulose E5. Transmission electron microscopy showed CSIC nanocrystals to be needle-like. Dynamic light scattering measurements showed a hydrodynamic size of 243 nm (polydispersity index < 0.3) and near neutral surface charge (− 7.8 mV). Particle size was maintained for at least 7 days in the liquid state and for at least 5 months after lyophilization. Drug content in the CSIC nanocrystal formulation (nanosuspension) was 0.8 mg/mL, which is 1000 times higher than the aqueous solubility of CSIC. In vitro release study showed that over 90% of CSIC was released from the nanocrystal formulation in a linear fashion over a period of 4 days. Importantly, CSIC nanocrystals showed equivalent cell-based anti-HIV activity (EC50 ~ 1 nM) as that of non-formulated drug. In vitro studies demonstrated rapid macrophage uptake of CSIC nanocrystals via both energy-dependent (endocytosis) and independent processes. In vivo studies in Swiss Webster female mice showed that the nanocrystal formulation significantly improved CSIC delivery to mouse cervicovaginal tissues following intravaginal instillation. In summary, nanocrystals are a promising formulation approach for topical delivery of CSIC for protection against HIV sexual transmission.
Beyond Heart Failure and Ischemic Heart Disease: A Scoping Review of Novel Uses of Ivabradine in Adults.

Ivabradine lowers heart rate by inhibiting the hyperpolarization-activated current in pacemaker cells, and its use for the treatment of heart failure (HF) and ischemic heart disease (IHD) is well described. Ivabradine may be an attractive treatment option for other conditions for which a reduction in heart rate is desirable but less is known about its role in these settings. The primary objective was to perform a scoping review summarizing the literature evaluating novel uses for ivabradine other than HF and IHD in adults. PubMed and EMBASE were searched for articles for all dates through September 2019. Search strategies combined terms generic, commercial/trade, and international names for ivabradine. Manual search of references was also performed to identify additional articles. Studies were included if they were published in English, evaluated the efficacy of ivabradine for indications other than HF or IHD in patients aged 18 years or older, and the primary outcome included clinically relevant end points. Articles were screened first by title and abstract followed by full-text screening of the remaining articles. After removal of duplicates, 1807 records were screened for inclusion and 84 studies were included in this scoping review. Novel uses of ivabradine were reported for various tachyarrhythmias, valvular heart disease, premedication for coronary computed tomography angiography, perioperative risk reduction, sepsis with and without multi-organ dysfunction syndrome, cor pulmonale, reactive airway disease, and erectile dysfunction. This scoping review identified several potential novel uses for ivabradine in adults. This review may help to identify existing gaps where further research is needed to elucidate the role of ivabradine for indications beyond HF and IHD.
Impact of Lung Parenchymal-Only Failure on Overall Survival in Early-Stage Lung Cancer Patients Treated With Stereotactic Ablative Radiotherapy.

Abstract Introduction The impact of lung parenchymal-only failure on patient survival after stereotactic ablative body radiotherapy (SABR) for early stage non-small cell lung cancer (NSCLC) remains unclear. Methods The study population included 481 patients with early stage NSC LC who were treated with 3 to 5 fraction SABR between 2000 and 2016. The primary study objective was to assess the impact of out-of-field lung parenchymal-only failure (OLPF) on overall survival (OS). Results At a median follow-up of 5.9 years, the median OS was 2.7 years for all patients. Patients with (OLPF) did not have a significantly different OS compared to patients who never failed (p=0.0952, median OS 4.1 years with failure vs. 2.6 years never failure). Analysis in a 1:1 propensity score-matched cohort for KPS, co-morbidity score, and smoking status showed no differences in OS between patients that never failed and those with OLPF (p=0.8). In subgroup analyses exploring impact of time of failure on OS, patients with OLPF 6 months or more after diagnosis did not have significantly different OS compared to those who never failed, when accounting for immortal time bias (p= 0.3, median OS 4.3 years vs 3.5 years never failure). Only seven patients in our dataset failed within 6 months of treatment, of which only four were confirmed to be true failures; therefore, limited data is available in our cohort on the impact of OLPF in ≤6 months on OS. Conclusions OLPF after SABR for early stage NSCLC does not appear to adversely affect OS, especially if occurring at least 6 months after SABR. More studies are needed to understand if OLPF within 6 months of SABR is associated with adverse OS. These data are useful when discussing prognosis of lung parenchymal failures after initial SABR.
A Research Protocol and Case Report of Emergency Department Endovascular Aortic Occlusion (REBOA) in Non-traumatic Cardiac Arrest

Background There are over 395,000 out-of-hospital cardiac arrests (OHCA) annually in the United States with an estimated 70-90% mortality rate and fewer than 10% surviving with a favorable neurologic outcome. Research in animal models and early human studies suggests that REBOA may play a role in augmenting coronary perfusion during OHCA by reducing blood flow to the lower body and re-directing it towards the heart and brain. We describe our initial case and research protocol to investigate the feasibility of REBOA in the emergency department (ED) for OHCA as an adjunct to ACLS. Methods We plan to enroll twenty patients in a single-arm interventional device study utilizing an exception from informed consent over a two-year period. The primary outcome is feasibility, with secondary outcomes assessing for hemodynamic changes pre- and post-aortic occlusion. Results Enrollment began in January 2020 and is ongoing. For the initial patient, an EP obtained ultrasound guided common femoral arterial access under chest compressions, followed by advancement of the REBOA catheter by an interventional radiologist. Immediately after aortic occlusion, investigators noted a substantial improvement in mean arterial pressure (MAP) (37 mmHg to 50 mmHg) and end tidal carbon dioxide (ETCO2) (33 mmHg to 50 mmHg), with transient but non-sustained return of spontaneous circulation (ROSC). Conclusion This is the first research protocol and case report of ED-REBOA initiation involving emergency physicians (EP) for non-traumatic OHCA. We describe our research protocol and initial case of a patient in OHCA who and underwent successful REBOA placement in the ED as an adjunct to ACLS.
Student Affiliates of Seventeen (SAS) 2021 Report

The University of Missouri–Columbia’s (MU) counseling psychology program was selected to host the Student Affiliates of Seventeen (SAS) Executive Board from 2019–2022 and is currently in the second...
Obstructive sleep apnea predicts 10-year cardiovascular disease related mortality in the Sleep Heart Health Study: a machine learning approach

Study Objectives: Obstructive sleep apnea (OSA) is considered to be an important risk factor for the development of cardiovascular disease (CVD). This study aimed to develop and evaluate a machine ...
Rapid Cycle Deliberate Practice in Virtual Reality: Teaching Transvenous Pacemaker Insertion to Emergency Medicine Residents

Introduction Transvenous pacemaker insertion is a critical life-saving procedure that is infrequently performed. Traditional mannequin-based training paradigms are resource intensive and sometimes inadequate due to time constraints. Rapid Cycle Deliberate Practice (RCDP) is an effective teaching modality for highly scripted procedures. We propose using a simulation-based technique of RCDP in virtual reality (VR) to teach this procedure. Methods Sixteen emergency medicine residents were recruited. A pre-survey was administered at the start of the session, followed by a baseline task trainer checklist-based assessment. This checklist was created based on expert consensus. Participants then underwent the RCDP VR intervention with a subsequent repeat checklist-based assessment as well as a post-survey. Results Post-test scores were found to be significantly higher than pre-test scores after residents completed VR deliberate practice simulation (19.5±3.5 vs 24.1±2.0; p<0.001). Subanalysis did not reveal any significant difference based on post-graduate year, previous performance of procedure on a live patient, or previous VR experience. The experience increased participant feelings of preparedness and comfort in performing the procedure (2-disagree vs 4-agree) based on a 5-point Likert scale. Conclusions Virtual reality using RCDP to teach transvenous pacemaker insertion demonstrated an improvement in task trainer performance. Further investigation into whether this translates into better patient outcomes or can be generalized to other procedures needs to be considered.
Influence of Personality Traits on Post-Traumatic Cognitions of Sexual Assault.

Sexual assault is a common form of trauma that is associated with psychological distress for many people who experience it. One factor that influences the degree to which sexual assault survivors exhibit distress is the cognitions they form related to the assault in its aftermath. The more times the assault happens, the more disruptive are the post-traumatic cognitions, although both the frequency of sexual assault and nature of post-traumatic cognitions differ by gender. Another factor that may influence post-traumatic cognitions is personality, which emerging research suggests has an influence on post-traumatic response in general and post-traumatic cognitions in particular. However, there is little research on the influence of personality on post-traumatic cognitions related to sexual assault specifically. In this study, we examine the association between personality traits (Agreeableness, Conscientiousness, Extraversion, Neuroticism, and Openness) and post-traumatic cognitions of sexual assault in a sample of sexual assault survivors recruited from Amazon's Mechanical Turk (N = 303) using a Bayesian approach to multiple regression. Results suggest that although the influence of traits varied depending on the post-traumatic cognition under analysis and the sex of the sexual assault survivor, Neuroticism was the primary predictor of post-traumatic cognitions over and above sexual assault frequency, although this applied more for men than for women. Study findings clarify previous research on the role of personality traits in post-traumatic response and suggest directions for future research and clinical intervention.
Molluscan Shellfish Depuration

Abstract: Successful wet storage, depuration and relaying of molluscan shellfish is a consequence of complete purging of the shellfish tissue in an allotted time period using carefully controlled seawater conditions. By harvesting the cleanest shellfish available and placing the shellfish in a seawater environment that optimizes their filter feeding activity, wet storage, relaying and depuration can be optimized.
ELECTRON MICROSCOPY OF AXIAL FIBRILS, OUTER ENVELOPE, AND CELL DIVISION OF CERTAIN ORAL SPIROCHETES.

Listgarten, M. A. (Harvard School of Dental Medicine and Forsyth Dental Center, Boston, Mass.), and S. S. Socransky. Electron microscopy of axial fibrils, outer envelope, and cell division of certain oral spirochetes. J. Bacteriol. 88: 1087–1103. 1964.—The ultrastructure of axial fibrils and outer envelopes of a number of oral spirochetes was studied in thin sections and by negative contrast. The axial fibrils measured 150 to 200 A in diameter. Only one end of each fibril was inserted subterminally into the protoplasmic cylinder by means of a 400 A wide disc. The free ends of fibrils inserted near one end of the cylinder extended toward, and overlapped in close apposition, the free ends of fibrils inserted at the other end. In thin sections, some axial fibrils showed a substructure, suggestive of a dense central core. The outer envelopes of most spirochetes appeared to consist of 80 A wide polygonal structural subunits. However, in one large spirochete, the outer envelope demonstrated a “pin-striped” pattern. Cell division in a pure culture of Treponema microdentium was studied by negative contrast. Results suggested that this organism divides by transverse fission, the outer envelope being last to divide. During the course of division, new axial fibrils appeared to originate on either side of the point of constriction of the protoplasmic cylinder. Flagellalike extensions which were found in rapidly dividing organisms were due to protruding axial fibrils, and appeared to be the result of cell division. Some evidence is presented to support the concept of a homologous origin for axial fibrils and flagella. Images
EBV-Positive Diffuse Large B-Cell Lymphoma of the Elderly

The purpose of this chapter is to provide a thorough summary of the existing knowledge of EBV-positive DLBCL of the elderly. We will discuss the pathogenesis behind EBV-driven malignant transformation of B-cells, the different EBV latency patterns associated with DLBCL, the distinct pathological characteristics of EBV-positive DLBCL, the differential diagnosis of EBV-positive DLBCL, the clinical characteristics of patients with EBV-positive DLBCL of the elderly, the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL, and potential strategies for the treatment of this rare entity.
Data and computation abstractions for dynamic and irregular computations

Effective data distribution and parallelization of computations involving irregular data structures is a challenging task. We address the twin-problems in the context of computations involving block-sparse matrices. The programming model provides a global view of a distributed block-sparse matrix. Abstractions are provided for the user to express the parallel tasks in the computation. The tasks are mapped onto processors to ensure load balance and locality. The abstractions are based on the Aggregate Remote Memory Copy Interface, and are interoperable with the Global Arrays programming suite and MPI. Results are presented that demonstrate the utility of the approach.
Mixed Communities: Gentrification by Stealth? Gary Bridge, Tim Butler, and Loretta Lees

Mix Communities: Gentrification by Stealth? is an edited volume by Gary Bridge, Tim Butler, and Loretta Lees which examines the rise of social mix as an urban policy and planning goal in a variety ...
Positive technological development: a systems approach to understanding youth development and educational technology

Youth development is multifaceted. While educational researchers have paid attention to one or few of these foci, it is imperative to understand how our technologies influence the various facets of youth development. We developed the Positive Technological Development research model to detail the overall impact of a technology on youth. We present a study describing how the PTD model illustrates the impact of an educational technology, while illuminating design areas that need to be revised.
The Unbounded Self: Peak Experiences and Border Crossings in Southern Indiana

In early visits to Lothlorien—which is a loosely Pagan community of environmentalists in Indiana—I was confounded by attempts to categorize either the place or the people. As one of the founders said, “I tend to run from labels so I don't know what I am. It's safer that way.” In this paper I explore four members’ narratives about the emotional high points in their lives, where they often cross the usual boundaries of self and other. At the same time the subjectivity at the core of these experiences is something that is felt and that cannot be dismissed as a discursive construct. Through these narratives I attempt to understand selfhood as a process—experientially inescapable but essentially in flux. I see a strong case for anthropologists moving beyond an overly neat, overly dichotomized view of “Western” and “non-Western” senses of self.
Ecdysteroids and regeneration in the fiddler crab Uca pugilator

Regeneration of lost walking legs in the fiddler crab Uca pugilator is divided into three distinct phases—wound healing, basal growth, and proecdysial growth. By means of HPLC/RIA analysis of levels and composition of endogenous ecdysteroid hormones and in vitro assays of 14C-leucine incorporation, we have determined that the transition between anecdysis and proecdysis is the point at which limb bud growth is most affected by ecdysteroids. The growth that occurs during proecdysis is programmed during the anecdysis/proecdysis transition by a small peak of ecdysteroids (Peak I). Early exposure to 20-hydroxyecdysone at this critical window is necessary for further proecdysial growth of limb buds. The later peak of ecdysteroids (Peak II) seen in the hemolymph of these crabs during late proecdysis does not seem to be involved in the regeneration process.
Axon development in mouse cerebellum: embryonic axon forms and expression of synapsin I

A fundamental question in central nervous system development is the timing of synaptogenesis in relation to invasion of targets by afferent axons. A related question is how growth cones transform into synaptic terminals. These two aspects of axon maturation were examined in developing mouse cerebellum, by labeling single axons with horseradish peroxidase, to study their form and cytology, and by immunocytochemical staining of a synaptic vesicle antigen, synapsin I, a phosphoprotein found on synaptic vesicles in all mature CNS synapses. From embryonic day 16 to postnatal day 3, horseradish peroxidase-labeled afferent axons extend well into the cerebellum and have simple forms. At embryonic day 16, axon growing tips are synapsin I-negative. Synapsin I is first expressed at embryonic day 17, and by embryonic day 18, fibers are stained throughout the cerebellum. Synapsin I expression coincides with a general increase in synaptic specializations, although growing tips continue to have the cytology of growth cones. During the period that axons have primitive shapes, synapsin I is distributed throughout the terminal arbor, corresponding to the presence of small vesicles along neurite lengths, even at non-synaptic sites. After postnatal day 3, when synaptic terminals develop into stereotypic shapes and engage in characteristic synaptic relations, synapsin I is restricted to boutons. Thus, the synapse-specific protein synapsin I is expressed in fetal mouse brain, long before nerve endings have the structure and connections of adult brain. In cerebellar axons, the expression of this protein follows axon arrival, coincides with the appearance of elementary synapses, and accompanies the transformation of growing tips into stereotypic synaptic boutons. The time course of expression of synapsin I, a phosphoprotein that may be involved in synaptic efficacy, suggests that transmitter release may influence early axon-target cell interactions.
Birth Complications and the Distribution of Handedness

Abstract In an attempt to clarify the relationship between self-reported birth complications and handedness, the handedness distributions of 181 college students who reported birth complications and 1320 students who reported no complications were compared. The results suggest a clear but modest shift in the birth complications group away from the dextral end of the continuum. However, these data did not validate the hypothesis that left-handedness results from birth complications.
Organizational Impacts on Community Policing: Management Issues and Officers' Perceptions

Although critical to the success of community policing implementation, the management element of community policing has often been overlooked. This study surveyed 198 officers of a police department regarding their attitudes toward this internal factor. Among the significant findings were the following observations: most officers did not believe their chief possessed leadership skills needed to implement community policing programs; officers who had received training on community policing more strongly agreed, compared to those who had not, that the chief's current management style and the department's organizational climate were not conducive to community policing implementation; and administrative personnel much more strongly believed, compared to the patrol, detective, and services officers, that the leadership and management style of the chief were helpful in implementing community policing programs. The paper concludes that chief executives must convey their understanding of the community policing concept to their officers, and nurture the growth of community policing by creating an environment conducive to community policing implementation.
INFORMATION SYSTEM TRENDS INFLUENCING SYSTEMS ENGINEERING

Government and industry are focusing on “information” system technology to provide dramatic changes that will be the critical factors in a comprehensive range of activities from achieving-competitive-advantage to winning-wars. System, software, and security engineering for information systems involve principles and practices that continue to evolve. This paper identifies, compares, and questions those principles and practices. It characterizes the information system development/integration paradigms as being in a state of flux. In addition, architectural concepts are discussed that provide a framework for information system services that support a variety of missions and functions. Three salient points of the paper are: (1) system engineers should become familiar with “technical” information system architecture alternatives, (2) advances in technology are leading to the merging of system, software, and hardware engineering disciplines at the architectural level, and (3) requirements-definition and design-resolution procedures are being revolutionized through incremental/continuous development paradigms.