cssi/SciSciGPT-SciSciNet huggingface dataset:
Rectangular waveguide shape folded patch antenna

A microstrip patch antenna is one of the most popular resonance antennas due to its light weight and easy fabrication and therefore widely used for many commercial electronic devices such as GPS receivers and for military applications such as airborne and aerospace communication [1]. A conventional patch antenna is constructed by two metallic layers which are separated by a thin dielectric layer. The upper metallic layer is responsible for radiation while the lower one works as the ground plane blocking electromagnetic (EM) waves propagating to the ground plane direction. Since the patch antenna shows good directivity in the broad side of the upper patch, electronic circuitry placed behind the ground plane would have little electromagnetic interference (EMI) from patch antenna radiation.
Diagnostic imaging of the adult airway

Imaging evaluation of the airway is essential in a variety of clinical situations. The role of imaging in diagnosis and management of disease processes involving the oropharynx, hypopharynx, larynx, and trachea is discussed. Characteristic imaging futures of several disorders are illustrated.
Seasonal Changes in Dry Matter Partitioning, Yield, and Crude Protein of Intermediate Wheatgrass and Smooth Bromegrass

Seasonal patterns of dry matter partitioning and nutritive value of leaf and stem components of grass species is important for selecting species for planting, planning grazing strategies, and making management decisions. Our objective was to compare dry matter yield and crude protein (CP) yield of blade, sheath, and stem fractions of intermediate wheatgrass [Elytrigia intermedia (Host) Nevski] and smooth bromegrass (Bromus inermis Leyss.) during the growing season. Intermediate wheatgrass and smooth bromegrass were sampled on a weekly basis from 14 May to 25 June in 1997 and from 5 May to 23 June in 1998 at Lincoln, NE. Samples were separated into blade, sheath, stem, and inflorescence components and yield and concentration of CP were determined. Smooth bromegrass tended to have greater blade and stem yield than intermediate wheatgrass during the 1997 and 1998 sampling periods. Yield of sheath was similar between species. Crude protein yield of blade and stem was also greater for smooth bromegrass than intermediate wheatgrass in both years. Sheath CP yield was greater for intermediate wheatgrass in 1998. Both species followed a similar pattern of dry matter accumulation; however, intermediate wheatgrass dry matter accumulation, especially stem, tended to be 1 to 2 wk behind smooth bromegrass. Differences in dry matter partitioning, yield, and CP in these two species illustrates the advantages having a complement of forage species. Choosing a diversity of species with differing growth habits would be beneficial for improving the distribution of forage yield and quality to match the seasonal demand of grazing livestock.
Replication control for distributed real-time database systems

An algorithm that integrates real-time scheduling with replication control is presented. The algorithm adopts a token-based scheme for replication control and attempts to balance the urgency of real-time transactions with the conflict resolution policies. In addition, the algorithm employs epsilon-serializability (ESR), a correctness criterion that is less stringent than conventional one-copy serializability. The algorithm is flexible and very practical, since no prior knowledge of data requirements or execution time of each transaction is required. >
Design of 6-Band Tight Frame Wavelets With Limited Redundancy

In this paper we explore the design of tight frame wavelets with a dilation factor M = 4. The resulting limit functions are significantly smoother than their orthogonal counterparts. An advantage of the proposed filters over the dyadic filterbanks is that the proposed filterbanks result in a reduced redundancy when compared with dyadic tight frames, while maintaining smoothness. The proposed filterbanks generate five wavelets and a scaling function with the underlying filters related as follows: H5?i(z) = Hi(?z), i = 0. . . 5.
Effect of Doximity Residency Rankings on Residency Applicants' Program Choices.

Author(s): Rolston, Aimee; Hartley, Sarah E.; Khandelwal, Sorabh; Christner, Jenny G.; Cheng, Debbie F.; Caty, Rachel M.; Santen, Sally A. | Abstract: Introduction: Choosing a residency program is a stressful and important decision. Doximity released residency program rankings by specialty in September 2014. This study sought to investigate the impact of those rankings on residency application choices made by fourth year medical students. Methods: A 12-item survey was administered in October 2014 to fourth year medical students at three schools. Students indicated their specialty, awareness of and perceived accuracy of the rankings, and the rankings’ impact on the programs to which they chose to apply. Descriptive statistics were reported for all students and those applying to Emergency Medicine (EM). Results: A total of 461 (75.8%) students responded, with 425 applying in one of the 20 Doximity ranked specialties. Of the 425, 247 (58%) were aware of the rankings and 177 looked at them. On a 1-100 scale (100=very accurate), students reported a mean ranking accuracy rating of 56.7 (SD 20.3). Forty-five percent of students who looked at the rankings modified the number of programs to which they applied. The majority added programs. Of the 47 students applying to EM, 18 looked at the rankings and 33% changed their application list with most adding programs.Conclusion: The Doximity rankings had real effects on students applying to residencies as almost half of students who looked at the rankings modified their program list. Additionally, students found the rankings to be moderately accurate. Graduating students might benefit from emphasis on more objective characterization of programs to assess in light of their own interests and personal/career goals.
Lessons from Visualizing the Functions of the Building Enclosure

A study completed in 2012, by the author, surveyed designers and builders about their use and understanding of the air barrier system in residential construction. Results show that a larger percentage of builders than designers reported always performing blower door tests on their projects. The study also showed that a larger percentage of builders than designers believe that an air barrier system must be continuous to be effective. It is well known that an air barrier system must be continuous to be completely effective and it is hypothesized that more builders believe this because they have first hand, visual experience of air infiltration. Blower door tests depressurize a building to expose air leaks through theenclosure. If visualization of air infiltration has convinced more builders of the importance of the air barrier system, what other visual and experiential tests of the building enclosure could be devised for building professionals to reinforce the importance of other enclosure components? This paper explores possibilities for new experiential tests for a highly misunderstood layer of the enclosure,the vapor retarder. Reasons for its misunderstanding are numerous: placement is climate based, it issometimes only millimeters thick, it is made of many parts, information on the topic is often unreliable and itis generally a confusing topic. For these reasons, the vapor retarder is often misused within the enclosure creating potential problems for structural rot and mold within walls. Is there an onsite testing option for this layer that would provide the same visual feedback that the blower door test gives for the air barrier system? This paper seeks to identify possible methods to teach building professionals using hands on experience and visualization about the function of the vapor retarder.
Limited but satisfied: low SES older adults experiences of aging in place

While many aging in place technologies have been explored in the literature, few have focused on low socioeconomic status (SES) populations. Contextual observations (n=8) were used to gain an in-depth view of the daily needs and challenges of low SES older adults and to provide insights into their experiences of health in and around the home. Our findings have implications not only for the kinds of technologies this population could benefit from, but the way in which such technologies are designed to fit into their current lifestyle.
We Know Where You Are: In Space and Place - Enriching the Geographical Context through Social Media

The convergence of social media and GIS provides an opportunity to reconcile space-based GIS and place-based social media. For this purpose, the authors conduct an empirical study in Columbus, Ohio, aiming to enrich both the spatial and platial context of geo-tagged data, using location-based social media Foursquare checkins as an example. An exploratory analytical approached is used to enrich the geographic context of social media data in both space and place. Specifically, exploratory spatial data analysis and point of interest matching are applied to analyze about 50,000 checkins crawled from social media feeds. It is found that checkins tend to be spatially clustered near the center of the city. Popular places related to food, services, and retail shopping venues are more likely to be reported by social media users. The authors also conducted platial analysis of the top 25 popular place venues in the study area.
Multi-material Preforming of Structural Composites

Fiber-reinforced composites offer significant weight reduction potential, with glass fiber composites already widely adopted. Carbon fiber composites deliver the greatest performance benefits, but their high cost has inhibited widespread adoption. This project demonstrates that hybrid carbon-glass solutions can realize most of the benefits of carbon fiber composites at much lower cost. ORNL and Owens Corning Reinforcements along with program participants at the ORISE collaborated to demonstrate methods for produce hybrid composites along with techniques to predict performance and economic tradeoffs. These predictions were then verified in testing coupons and more complex demonstration articles.
A cloud software system for visualization of game-based learning data collected on mobile devices

Digital game-based learning is a type of gameplay with a set of defined learning outcomes. Such gameplays are typically instrumented to collect data for assessing the learning outcomes. However, when the gameplay and data collection take place on a mobile device such as iPad, it becomes very difficult for a teacher to view the collected data on dozens of mobile devices used by students. This paper presents a cloud software system (CSS) under the client-server architecture to remedy this problem. We developed CSS using the Java platform, Enterprise Edition (Java EE) with IBM WebSphere Application Server, IBM DB2, and MongoDB. We also developed an educational iPad game called Taffy Town. Game-based learning data are collected on the iPad during the Taffy Town gameplay and are transmitted to our CSS over the Internet. Players (students) and teachers can login and view dynamically created visualizations of the collected learning data.
P2-S1.16 Social influences on relationship fidelity and concurrency patterns among Latino adolescents in San Francisco

Background Our previous research in San Francisco9s Mission District, a predominantly Latino neighbourhood characterised by high immigration, poverty, and gang-related violence, highlighted diverse partnership patterns among youth and the role of gang affiliation in high-risk sexual activity and pregnancy. 38% of Latino youth reported concurrent partnerships. Methods We conducted 33 semi-structured in-depth interviews with immigrant and US-born male and female Latino youth aged 16–21 to explore how the social environment affected partnership formation and STI risk. Participants were recruited from community venues; interviews were conducted in Spanish or English. Interview transcripts were coded in Atlast.ti. We analysed the following themes: relationship fidelity; STI prevention; and concurrency norms (agreement with the statement, Many Mission youth in a relationship are also seeing someone on the side). Results Participants were 48% female; had a mean age of 17.5 years; and 55% were immigrants from Mexico or Central America. 27 of 30 believed that concurrency is widespread, described as “cheating” (having a “main girl with ‘friends with benefits’ on the side”) or resulting from initiating new relationships before ending existing ones or between serial break-ups with a main partner. Infidelity was motivated by machismo, a cultural notion of masculinity that was heightened for men respected for having multiple partners; boredom with a single partner; an ideal that fidelity was only relevant within marriage with cheating expected prior to that; and revenge for known, suspected or pre-emptive cheating. Street gangs introduced distinct reasons for young males preferring multiple, casual partnerships: limited time for relationships because of obligations to the gang first and foremost; disinterest in committed relations to avoid emotional vulnerability given emotional demands of street life; and multiple partners bringing status: “you got more game; you got more reputation.” Young women recognised that having partners in a gang brought social prestige and articulated strategies for increasing intimacy (eg, pregnancy) to draw partners away from the street and strengthen commitment to the relationship. Despite a perception of pervasive concurrency, STI risk perception was low. Conclusions Many relationship norms and expectations held by youth supported concurrency, highlighting the importance of addressing social influences like gangs in STI prevention.
Independent or ungrateful? Consequences of confronting patronizing help for people with disabilities:

People with disabilities routinely face a dilemma in dealing with patronizing help: While accepting unsolicited assistance may be harmful for its recipients, confronting the helper can lead to nega...
Simulation Studies of a Total Absorption Dual Readout Calorimeter

We have created a flexible, easy to use simulation framework based on GEANT 4 to perform detailed simulations of a crystal based total absorption calorimeter with dual readout. The correction to the observed scintillation signal can be determined by comparison of the scintillation signal with the beam energy as a function of the Cerenkov-to-scintillation C/S ratio. In this article we describe the features of the software we developed and show results for various crystal materials and physics lists. We show that applying an energy-independent correction results in an energy resolution of ≈ 10%/√E for single π−.
LARGE VIBRATION OF A CLAMPED CIRCULAR COMPOSITE PLATE WITH A CONCENTRIC RIGID MASS

The investigation is concerned with the axisymmetric non-linear vibrations of a thin composite circular plate carrying a concentric rigid mass. Hamilton's principle is utilized to derive the von Karman equations and the associated boundary conditions. Harmonic vibrations are assumed and the time variable is eliminated by a Kantorovich averaging method. Numerical solutions are obtainable by introducing the related initial value problem. Responses of the free and forced vibrations of the plate-mass system are obtained. Basic Differential Equations and Approximate Analyses Consider a flat circular plate having an outer radius a, constant thickness h, and an attached concentric rigid mass, M . The radius of the rigid mass is b and equals th: inner radius of the plate. The geometry is shown in Figure 1. The plate material is assumed to be elastic and homogeneous, but the material is made of composites which behave as a cylindrically orthotropic plate. By Hamilton's principle, it can be shown that the equations of motion for a finite amplitude axisymmetric vibration of a circular plate with a concentric rigid mass in nondimensional form are,
Decrease in hexosamine content of epiphyseal plates in experimental lathyrism.

SummaryThe content of hexosamine and hydroxyproline in epiphyseal plates of lathyric and normal rabbits has been determined. A significant decrease (36%) of hexosamine was found in cartilage from experimental animals. Only small differences for hydroxyproline have been observed between experimental and control cartilage.
Semidefinite Approaches for MIQCP: Convex Relaxations and Practical Methods

We survey several recent advances on applying semidefinite programming (SDP) techniques to globally solve mixed-integer quadratically constrained programs (MIQCPs), or to construct convex relaxations with better tightness/complexity ratios. It is well known that on many MIQCPs, convex relaxations using SDP techniques produce some of the strongest bounds. On one hand, it is commonly thought that SDP relaxations are computationally expensive and hard to exploit in a branch-and-bound framework, where one needs to solve convex relaxations repeatedly. On the other hand, a large amount of effort has been devoted to find more practical ways to exploit strong SDP relaxations. We survey some attempts along this direction, which we conceptually categorized into three main approaches: (1) use first-order methods to solve SDP relaxations approximately; (2) exploit dual optimal solution to derive reformulations; (3) generate cuts in the original variable space by solving the (dual) SDP relaxations heuristically. Our paper does not aim to be a comprehensive survey on MIQCPs, but rather, to be supplementary to other survey papers in literature. We adopt a (partial-) Lagrangian framework in an effort to unify various theoretical and algorithmic developments with (sometimes) simpler notation.
A Rare Initial Presentation of Leukemia With Pneumocystis Jirovecii Pneumonia

Pneumocystis jirovecii pneumonia (PJP) causes life-threatening respiratory failure in immunocompromised patients such as patients with HIV infection, hematologic and solid malignancies, organ transplantations, and autoimmune diseases and patients receiving immunosupressive medications. In HIV patients, PJP usually takes an indolent course while in HIV negative but immunocompromised patients, the disease is usually severe and is associated with a high mortality rate. A high index of suspicion and early institution of therapy is warranted. We present a case of life-threatening PJP as the first manifestation in a patient with undiagnosed acute leukemia. J Med Cases. 2016;7(5):181-183 doi: http://dx.doi.org/10.14740/jmc2472w
Reconstruct the Productive Protection of Craftsmanship and Non-material Cultural Heritage

Fluidity is the basic characteristic of traditional craftsmanship as well as non-material cultural heritage.Maintaining difference as the nature of craftsmanship can provide foundation of living and eco-guard for the key to protection of non-material cultural heritage: to maintain its cultural difference.
[Processing, targeting and import into the mitochondria and peroxisomes of proteins coded by nuclear genes].

I have herein discussed two gene-enzyme families in maize whose protein products participate to purge toxic oxidants from cells, and are thus of importance to all aerobic organisms. We have demonstrated that plant mitochondria import precursor proteins (i.e., preSOD-3) in a manner analogous to other eukaryotic cells. The "transit peptide" (TP) of preSOD-3 is 31 amino acid long and has similar properties to other reported TPs for mitochondrial and chloroplastic proteins. Import to peroxisomes is uniquely different from that for mitochondria and chloroplasts in that no consensus presequence seems to be involved. Instead, targeting signals seem to be integral parts of peroxisomal proteins.
2,6-Diiminopiperidin-1-ol: an overlooked motif relevant to uranyl and transition metal binding on poly(amidoxime) adsorbents

Glutardiamidoxime, a structural motif on sorbents used in uranium extraction from seawater, was discovered to cyclize in situ at room temperature to 2,6-diimino-piperidin-1-ol in the presence of uranyl nitrate. The new diimino motif was also generated when exposed to competing transition metals Cu(ii) and Ni(ii). Multinuclear μ-O bridged U(vi), Cu(ii), and Ni(ii) complexes featuring bound diimino ligands were isolated.
PHOTOCHEMISTRY AND PHOTOBIOLOGY OF DNA CONTAINING 5-IODOURACIL AND 5-IODOCYTOSINE

ABSTRACT The quantum yields for the photolysis of iodinated derivatives of cytosine (leading to the loss of iodine) has been measured for 313 nm radiation and found to decrease from 0.024 for IodCMP down to 0.007 for both Poly(C) and DNA containing 5-IoCyt. In DNA, approximately 1 clean chain break and 1 alkali-labile bond were formed for every 10 iodines lost. Incorporation of iodinated cytosine or uracil into the DNA of Escherichia coli or Bacillus subtilis was shown to have a large effect on the biological survival following 313 nm radiation.
Unraveling the Scientific, Social, Political, and Economic Dimensions of Environmental Issues Through Role-Playing Simulations

The focus of this chapter is a role-play simulation unit within a college-level interdisciplinary science elective course for preservice teachers. The simulation utilized a United States Senate Subcommittee hearing to explore the use of Bt (Bacillus thuringiensis) genes in corn. Over an extended time period, students explored the material in depth, which incorporated a wide variety of teaching strategies and topics of current interest in science education (simulations, role-playing, driving questions, oral presentations, technology integration, portfolios, reflection, and concept mapping). The results demonstrated that this type of learning experience can significantly impact students’ understanding of how science is applied to environmental problems. Furthermore, students developed a greater appreciation of the importance of examining the scientific, social, political, economic, and ethical dimensions of environmental issues.
Blood utilization practices in elective surgical patients in a Tertiary Care Hospital of Uttarakhand

Background: Ordering of blood is a common practice in elective surgical procedures. Unnecessary blood orders need to be waived to reduce both workload and financial expenditure. We need to optimize the quantity of blood being cross-matched, by assigning each surgical procedure, a tariff of transfusion. To this effect, the maximum surgical blood ordering schedule(MSBOS) is one such approach. The study was performed with the aim of evaluating whether preoperative blood cross-matching in our hospital is well adjusted to the actual intraoperative blood usage. Materials and Methods: A hospital-based retrospective cross-sectional study was conducted in those patients who underwent elective surgeries in Himalayan Institute Hospital Trust hospital over a period of 1year. Blood requisitions and transfusions were compiled and reviewed. The number of units requested, cross-matched and transfused along with number of patients cross-matched and transfused were collected. The blood bank requisition forms, databases, old surgical records, and discharge sheets were reviewed. Following indices were calculated: (i) Cross-match to transfusion ratio(C/T), (ii) Transfusion probability(T%), (iii) Transfusion index(TI), (iv) MSBOS. Results: Atotal of 2370patients underwent 214 different elective procedures are included in this study. Totally, 1184 red blood cells units were cross-matched, and only 625 units(52.7%) were transfused to 331patients. The overall C/T ratio calculated was 1.8, TI was 0.5 and T% was 61.7%. All these figures were found to be within the desirable range. Based on these indices, MSBOS was formulated for each procedure. Conclusion: The study indicated an adequate overall ratio of C/T, T%, and TI except a few surgeries that showed transfusion indices beyond accepted levels. Developing a blood ordering policy(MSBOS), to guide the clinicians regarding blood usage can decrease over ordering of blood thereby reducing unnecessary compatibility testing, returning of unused blood, and wastage due to outdating.
Wolverine: A wearable haptic interface for grasping in virtual reality

The Wolverine is a mobile, wearable haptic device designed for simulating the grasping of rigid objects in a virtual reality interface. In contrast to prior work on wearable force feedback gloves, we focus on creating a low cost and lightweight device that renders a force directly between the thumb and three fingers to simulate objects held in pad opposition (precision) type grasps. Leveraging low-power brake-based locking sliders, the system can withstand over 100N of force between each finger and the thumb, and only consumes 0.24 mWh (0.87 joules) for each braking interaction. Integrated sensors are used both for feedback control and user input: time-of-flight sensors provide the position of each finger and an IMU provides overall orientation tracking. This paper describes the mechanical design, control strategy, and performance analysis of the Wolverine system and provides a comparison with several existing wearable haptic devices.
Briakinumab and Ustekinumab: Anti-p40 Antibodies for Inflammatory Bowel Disease Treatment

Interleukin-12 and interleukin-23 are innate immune system inflammatory cytokines that drive interferon-gamma and interleukin-17 responses, respectively. IL-12 and IL-23 share the same protein subunit, p40, which is contained in each of their heterodimeric structures. Crohn’s disease is characterized by increased production of the IL-12/INFγ and IL-23/IL-17 cytokines. Targeting p40 in several animal models of Crohn’s disease such as TNBS and CD4CD45RBhigh T cell transfer colitis has resulted in successful prevention and treatment of established gut inflammation. Briakinumab and ustekinumab are fully human monoclonal antibodies being tested for treatment in human Crohn’s disease. Preliminary results of clinical trials suggest that the early success of this novel strategy may be improved with better understanding of the drug’s pharmacology in Crohn’s patients and the validation of biomarkers that identify high probability of clinical response and remission.
What Factors Drive Trading around the World

This paper examines the implications of Lo and Wang’s (2000, 2006) mutual fund separation model in the cross-sectional behavior of global trading activity. It demonstrates that return-based factors work poorly around the world. On average across countries, market-wide turnover accounts for 37% of all systematic turnover components in individual stock trading, and two additional Fama and French (1993) factor turnovers increase the explanatory power by 23%. Similarly Lo and Wang’s (2000) turnovers account for on average only 64% of all systematic turnover components. Using this multifactor asset pricing-trading framework, a horse race is further performed to explore other factors in return which are important for explaining the common variation in turnover. All the return-based factors account for at most 67% of the common variation in trading, suggesting that stock pricing and trading volume may not be compatible around the world. In a cross-country analysis, the explanatory power of the return-based factor model varies substantially across countries and markets, with better performance for developed European markets and China. Surprisingly, in North America, Japan, and most emerging markets there are larger amounts of commonality in trading, usually higher than 47%, for reasons other than return motive.
International Real Yields

I study market-implied real yields extracted from prices of inflation-linked government bonds for nine developed countries. The liquidity premium is an important component of breakeven inflation rates. Unconditional real yield curves are upward-sloping, providing empirical support for habit models. The cross-country real rate equality is rejected. Across countries, real yields are strongly positively correlated while liquidity premia are moderately positively correlated. Low nominal yields following the Great Recession are mainly due to low real yields, although the inflation risk premia have also decreased.
Conditionally Parametric Quantile Regression

Chapter 2 demonstrated that nonparametric approaches can easily be adapted to quantile regression models. In the case of a single explanatory variable, x, all that is necessary to make the model nonparametric is to add a kernel weight function \( k\left( {\left( {x - x_{t} } \right)/h} \right) \) when estimating a quantile regression for a target point \( x_{t} \). After estimating the function for a series of target points, the estimates can then be interpolated to all values of x. The nonparametric approach is a flexible way to add nonlinearity to the estimated quantile regressions.
Identifying patients according to breast cancer stage and ER/HER2 receptor status using claims data.

e13096Background: Safety analyses of targeted oncology therapies often require cancer stage and receptor status. Automated claims databases offer the largest populations to study rare outcomes, but lack these characteristics. We conducted a validation study of claims data using predictive models to identify two cohorts of women with early-stage and advanced-stage ER+/HER2- breast cancer (ESBC and ASBC, respectively). Methods: Retrospective cohort and validation study using electronic data linkage of a nationwide claims database (HealthCore Integrated Research Database – HIRD) and Anthem’s Cancer Care Quality program (CCQP). The CCQP served as a validation sample. We used claims data to develop two predictive models to estimate breast cancer stage and receptor status. We applied these models to the HIRD to identify ER+/HER2- ESBC and ASBC cohorts. In each cohort we assessed adverse event (AE) rates. Results:: In addition to breast cancer diagnoses, predictive models for ER+/HER2- ESBC and ASBC included 21 ...
THE CHRONOLOGY OF THE FORMATIVE TO CLASSIC PERIOD TRANSITION AT IZAPA: A REEVALUATION

The site of Izapa, though famous for its unique “Izapan” style monuments, has lagged behind many other Mesoamerican centers in archaeological research. As revisions of important Mesoamerican chronologies are underway, Inomata and colleagues (2014) have questioned whether monument production at Izapa has been misplaced chronologically. This article applies new data from the Izapa Household Archaeology Project to assess Inomata and colleagues’ (2014) proposal for a shift in the chronology at Izapa. It specifically assesses the chronology for the Formative to Classic period transition at Izapa, from 100 BC to AD 400, with new excavation data, ceramic cross-dating, and Bayesian modeling of AMS dates from the southern periphery of the site. These data generally support the chronology developed by Gareth Lowe following the 1960s excavations at the site, though a temporal overlap appears possible for the Terminal Formative Hato and Itstapa ceramic complexes. Although results do not support Inomata and colleagues’ proposal for a shift in the Izapa chronology, ceramic cross-ties proposed between the Hato phase at Izapa and the Verbena phase at Kaminaljuyu support Inomata and colleagues’ (2014) revision for the chronology of Kaminaljuyu.
Clinical experience with the BCL2‐inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies

Introduction Venetoclax (VEN), a selective BCL2 inhibitor, has single-agent activity in relapsed and refractory (R/R) acute myeloid leukemia (AML), and efficacy in lower intensity combinations for treatment-naive elderly AML patients. VEN treatment combinations in R/R AML have not been previously reported. Methods All R/R myeloid patients (including AML, myelodysplastic syndrome (MDS), and blastic plasmacytoid dendritic cell neoplasm (BPDCN)) treated with VEN combinations in the salvage setting were reviewed. Results Forty-three patients with median age 68 (range, 25-83) were treated for AML (91%), MDS (5%), or BPDCN (5%). Most (n = 36, 84%) were ≥ salvage-2 treatment status, including prior hypomethylating agent (HMA) in 77%. In combination with VEN, most patients received HMA therapy (n = 31, 72%); eight (19%) received low-dose cytarabine (LDAC). Patients received a median of 2 treatment cycles (range, 1-4). Objective response was observed in 9 (21%) patients, including 2 complete responses (CR), 3 CRi, and 4 morphologic leukemia-free state (MLFS). Median survival was 3.0 months (range, 0.5-8.0), and estimated 6-month survival was 24%. Responses were observed in five (24%) of 21 patients with intermediate-risk cytogenetics, 3 (27%) of 11 IDH1/2-mutant, and 4 (50%) of 8 RUNX1-mutated patients. Two (20%) of 10 TP53-mutated patients responded; both had concurrent RUNX1 mutations. Of the 3 (15%) responding patients with adverse cytogenetics, all had concurrent RUNX1 mutations. Conclusion Low-intensity chemotherapy, including HMAs or LDAC, in combination with VEN is a viable salvage option, even in multiply relapsed/refractory patients with AML, MDS, and BPDCN. Notable responses were identified in patients with diploid/intermediate cytogenetics, RUNX1, and/or IDH1/2 mutations.
Heart rate compression & time reduction method for HRV monitoring in athletes

Heart rate variability (HRV), a feature extracted from the heart rate signal, is commonly used for monitoring training loads, and fitness status within athletes. Various sensors can be used to ascertain HRV within athletes; two of which are considered within this investigation, namely PPG and ECG. We present methods for HRV collection and calculation using PPG, reducing HRV collection time requirement by 50%, and compressing signals by an order of 6x for effective field-based data collection.
Core Reliability: Leveraging Hardware Transactional Memory

Modern microprocessors are more vulnerable to transient faults or soft errors than ever before due to design trends mandating low supply voltage and reduced noise margins, shrinking feature sizes and increased transistor density for fast, low-power circuits. As industry now supports Hardware Transactional Memory (HTM), the features of HTM can be leveraged to add core resiliency to transient errors. In this paper, we propose a novel microarchitecture for transient error detection and recovery based on time redundancy and backward error recovery leveraging HTM's existing features especially its rollback mechanism. We provide implementation details for single-core reliability, minimizing additions to existing HTM supports. We evaluate the performance overheads of the single core with the reliability feature by comparing it to the base machine without the reliability feature. Finally we show how single-core reliability can be extended to multi-core reliability.
P190RhoGAP prevents mitotic spindle fragmentation and is required to activate Aurora A kinase at acentriolar poles

Assembly of the mitotic spindle is essential for proper chromosome segregation during mitosis. Maintenance of spindle poles requires precise regulation of kinesin- and dynein-generated forces, and improper regulation of these forces disrupts pole integrity leading to pole fragmentation. The formation and function of the mitotic spindle are regulated by many proteins, including Aurora A kinase and the motor proteins Kif2a and Eg5. Here, we characterize a surprising role for the RhoA GTPase-activating protein, p190RhoGAP, in regulating the mitotic spindle. We show that cells depleted of p190RhoGAP arrest for long periods in mitosis during which cells go through multiple transitions between having bipolar and multipolar spindles. Most of the p190RhoGAP-depleted cells finally achieve a stable bipolar attachment and proceed through anaphase. The multipolar spindle phenotype can be rescued by low doses of an Eg5 inhibitor. Moreover, we show that p190RhoGAP-depleted multipolar cells localize Aurora A to all the poles, but the kinase is only activated at the two centriolar poles. Overall, our data identify an unappreciated connection between p190RhoGAP and the proteins that control spindle poles including Aurora A kinase and Eg5 that is required to prevent or correct spindle pole fragmentation.
Comparing outcomes and costs following cardiovascular imaging: a SPARC…but further illumination is needed.

Stress single-photon emission computed tomography (SPECT) myocardial perfusion imaging is a historically robust, noninvasive technique, and represents the most common imaging method used in the United States for evaluation of patients with suspected or known coronary artery disease (CAD). On the
Reaching Consensus on Social Networks

Research in sociology studies the effectiveness of social networks in achieving computational tasks. Typically the agents who are supposed to achieve a task are unaware of the underlying social network except their immediate friends. They have limited memory, communication, and coordination. These limitations result in computational obstacles in achieving otherwise trivial computational problems. One of the simplest problems studied in the social sciences involves reaching a consensus among players between two alternatives which are otherwise indistinguishable. In this paper we formalize the computational model of social networks. We then analyze the consensus problem as well as the problem of reaching a consensus which is identical to the majority of the original signals. In both models we seek to minimize the time it takes players to reach a consensus.
The Replication Perspective on Productive Knowledge

Replication is the process of creating, in new geographical locales, productive units that operate in a manner highly similar to existing units elsewhere – a type of effort typically undertaken in an attempt to realize economic benefits in the new sites that are comparable to those already achieved in existing sites. The transfer of knowledge to the new units is a fundamental part of the replication process.
Thrombin Disintegrates Cell Surface Urokinase Focal Adhesion Plaques and Decreases Cell Extension: Implications for Axonal Growth

In addition to its function as the ultimate protease in the coagulation cascade thrombin has several hormone-like effects on cells in vitro. This serine protease is a potent mitogen for fibroblastic cells from several species.1,2 In addition, like other growth factors,3 thrombin can modulate cellular differentiation. Thrombin or a closely related protease present on neuroblastoma cells antagonizes formation of neurite extensions.4 Furthermore thrombin has recently been identified as the primary serum inhibitor of neurite extension in neuroblastoma cell cultures.5 In the present paper we show that thrombin, but not other growth factors tested, causes the disappearance on human fibroblasts of linear strands of cell surface urokinase-type plasminogen activator, strands which have recently been shown to colocalize with cell-to-substratum focal adhesion plaques (FAPs)6,7 Disappearance or gross alteration of FAPs in fact accompanies the thrombin-mediated dissolution of the cell surfaced urokinase strands.
Effectiveness of Methods Used to Teach Breast Self-Examination

The efficacy of breast self-examination (BSE) is limited by the extent to which women can be taught to perform a frequent and proficient examination. We randomized 783 women from a health maintenance organization into group instruction, individual instruction, individual instruction with a reminder system, or minimal intervention designed to simulate an office encounter where BSE was encouraged but not taught. The percentage of lumps 1 cm and smaller detected in silicone breast models, the number of false-positive detections, the search technique, and the self-reported BSE frequency were measured before and four months after intervention. Multiple tests for comparisons of interventions showed that the interventions containing BSE instruction were comparable in increasing trueand false-positive detection of lumps and in improving search technique, but the minimal intervention resulted in lower scores for all three outcomes (P
Ultrasound for identifying the cricothyroid membrane prior to the anticipated difficult airway.

Abstract Background Prior to the anticipated difficult airway, the emergency physician commonly palpates the neck to identify the presumed location of the cricothyroid membrane (CTM). In the event of a “cannot-intubate, cannot‑oxygenate” airway, precise CTM localization is vital to the success of a cricothyrotomy and hence, the patient's survival. Objective This narrative review will summarize the prospective studies evaluating CTM identification. It will demonstrate the inaccuracy of the classically used landmark palpation technique. It will then describe the use of ultrasound (US) as a superior tool for CTM identification, illustrate the technique itself, and propose its implementation in the pre-intubation checklist for the anticipated difficult airway. Discussion Evidence demonstrates that physicians are not sufficiently accurate in palpating the CTM in both cadavers and volunteers in a stable non-emergent setting. In preparing for a real-time intubation, this fine motor task would be more difficult to achieve. Moreover, this particular patient group may often exhibit difficult airway features. US has been demonstrated to be superior for locating the CTM than landmark palpation across body habitus, gender, and failed airway simulations. This technique carries a short learning curve even without prior airway US experience, along with a high retention rate. An illustrative tutorial is provided. Conclusion Emergency physicians may apply this US technique for CTM localization in preparation for an anticipated difficult airway. However, since this technique takes longer than landmark palpation, using US is not recommended once already in the midst of a failed airway situation.
CCDLC Detection Framework-Combining Clustering with Deep Learning Classification for Semantic Clones

Code clones introduce difficulties in software maintenance and cause bug propagation. We propose a framework for detecting Java code obfuscation and both syntactic and semantic clones by adding cluster data which is using the sequential information bottleneck algorithm with (CNN) deep learing classification, called CCDLC. The CCDLC uses a novel Java bytecode dependency graph (BDG) along with program dependency graph (PDG) and abstract syntax tree (AST) features. We use several publicly available code clone and Java obfuscated code datasets for validating effectiveness of our framework. Our experimental results and evaluation indicate that using the combination of clustering and deep learning classification is a viable methodology, since they improve detecting clones and obfuscation code on the corpus. The key benefit of this approach is that our tool can improve detecting obfuscation accuracy about 5.44% and improve finding both Syntactic and Semantic clones accuracy about 12%
New Opportunities For Research Publication

Just as the Internet is transforming traditional teaching models in medical education, it also is changing the publication model for scholarly work as evidenced by the growth in open access journals no longer tied to the volume/issue cycles of traditional printing. Medical schools around the world are adopting this concept to facilitate publication resulting from early research involvement of students and the transition to academic medicine of residents and fellows.
Climate Change and Migration: New Insights from a Dynamic Model of Out-Migration and Return Migration

In popular accounts, stories of environmental refugees convey a bleak picture of the impacts of climate change on migration. Scholarly research is less conclusive, with studies finding varying effects. This paper uses an agent-based model (ABM) of land use, social networks, and household dynamics to examine how extreme floods and droughts affect migration in Northeast Thailand. The ABM explicitly models the dynamic and interactive pathways through which climate-migration relationships might operate, including coupled out and return streams. Results suggest minimal effects on out-migration but marked negative effects on return. Social networks play a pivotal role in producing these patterns. In all, the portrait of climate change and migration painted by focusing only on environmental refugees is too simple. Climate change operates on already established migration processes that are part and parcel of the life course, embedded in dynamic social networks, and incorporated in larger interactive systems where out- and return migration are integrally connected.
The gain-of-function allele bamAE470K bypasses the essential requirement for BamD in β-barrel outer membrane protein assembly.

The outer membrane (OM) of gram-negative bacteria confers innate resistance to toxins and antibiotics. Integral β-barrel outer membrane proteins (OMPs) function to establish and maintain the selective permeability of the OM. OMPs are assembled into the OM by the β-barrel assembly machine (BAM), which is composed of one OMP—BamA—and four lipoproteins—BamB, C, D, and E. BamB, C, and E can be removed individually with only minor effects on barrier function; however, depletion of either BamA or BamD causes a global defect in OMP assembly and results in cell death. We have identified a gain-of-function mutation, bamAE470K, that bypasses the requirement for BamD. Although bamD::kan bamAE470K cells exhibit growth and OM barrier defects, they assemble OMPs with surprising robustness. Our results demonstrate that BamD does not play a catalytic role in OMP assembly, but rather functions to regulate the activity of BamA.
Wireless Charging System of Inspection Robot under Primary Self-Adaption Current Control

Wireless charging series-series compensation is one of the common compensation network. Due to the temperature drift of capacitor and the change of coil self-inductance at different relative positions, the resonant cavity will change. Therefore, the transmission efficiency and power stability of the system will be affected. This paper aims to improve the stability of wireless charging output. Firstly, the wireless charging series-series compensation network model is established, and the influence of resonant cavity and load on the system output characteristics is analyzed. Then, a self-adaption primary current control method is proposed. Finally, the simulation and experimental results proved that this control method can make the system have stable output characteristics.