cssi/SciSciGPT-SciSciNet huggingface dataset:
Needle Sharing for the Use of Therapeutic Drugs as a Potential AIDS Risk Behavior among Migrant Hispanic Farmworkers in the Eastern Stream

In the United States, 41 percent of the AIDS cases are found in ethnic minorities. While it is true that AIDS is disproportionately represented among minorities, not enough research has been directed at identifying risk factors peculiar to different ethnic groups. This study explored critical knowledge of AIDS, patterns of sexual behavior, and self-injection for therapeutic reasons among migrant workers. Data were collected through face to face interviews with 378 hispanic migrant workers. Respondents, seventy-nine (21.4 percent), reported self-injecting antibiotics and vitamins for medicinal reasons while only 2.6 percent self-injected recreational drugs. The likelihood of contracting AIDS escalates as the number of risk factors increase. Self-injection of therapeutic agents is a great risk when considered in concert with the other risk factors present in the migrant farmworker population. Exposure to additional factors such as sexual promiscuity, frequenting prostitutes, homosexual behavior and having vaginal or anal intercourse without a condom creates a potentially dangerous situation. Hence, each of the individual AIDS risk factors may be multiplied and broadcast through the needle risk. AIDS health education needs to deal with this cultural pattern of self-injection in its intervention programs.
Mongolismus — Down’s Syndrom

Zur Zeit gebrauchliche Synonyme: Mongolismus, Mongoloidismus, Down’s Syndrom, Down’s Anomalie, Downsehe Krankheit, Downismus, Trisomie 21.
Clinical Use of Biologic Response Modifiers in Cancer Treatment: An Overview Part II. Colony-Stimulating Factors and Interleukin-2

Colony-stimulating factors (CSFs) are hematopoietic growth hormones that stimulate the production, maturation, and function of white blood cells. The best studied are granulocyte-macrophage CSF (GM-CSF) and granulocyte CSF (G-CSF), both of which can be produced by recombinant DNA technology. Clinical indications for these agents include bone marrow failure secondary to administration of chemotherapeutic drugs or radiation, bone marrow transplantation, and a variety of congenital or iatrogenic neutropenias. Toxicity in usual clinical doses is mild, and consists mainly of bone pain and constitutional symptoms such as fever, headache, and myalgias. Interleukin-2 (IL-2) is a lymphokine that stimulates that multiplication of several types of killer cells. These cells can recognize and destroy foreign substances, such as tumors, without destroying normal cells. Major applications of IL-2 include treatment of patients with renal cell carcinoma, in whom the overall objective response rate is 15–30 percent, and ma...
An LMI Approach to Control of Exponentially Unstable Systems Subject to Saturation and Time-Varying Delay in the Input

This chapter studies the stabilization of exponentially unstable linear systems subject to saturation and time-varying delay in the input. The proposed stabilizing controller is developed in a two step process. First, the stabilizing controller for the system without saturation is obtained from the optimal solution to an iterative LMI problem, such that the upper bound of the delay function is maximized. Second, the input saturation is included in the analysis, and the previous iterative LMI problem is updated in order to maximize the domain of attraction of the closed-loop system. The effectiveness of the proposed methods is demonstrated through numerical examples, and by experimental validation on a test rig that captures the main operating characteristics of active magnetic bearings .
THE NATURE OF ELLIPTIC SECTORS IN THE PRINCIPAL FOLIATIONS OF SURFACE THEORY

Little is known of the geometry of the principal foliations on a smooth surface in R. The unsolved Caratheodory conjecture for such a surface would follow from Bendixson’s formula, were it known that the principal foliations never admit an elliptic sector at an isolated umbilic. Evidence in favour of the nonexistence of elliptic sectors in principal foliations is the main result and it offers a first geometric explanation of why the conjecture might be true for smooth surfaces.
A Differentiation Test for Absolute Convergence

(1984). A Differentiation Test for Absolute Convergence. Mathematics Magazine: Vol. 57, No. 4, pp. 228-231.
Comment on Whitt and Yago, "Corporate Strategies and the Decline of Transit in U.S. Cities" (Urban Affairs Quarterly 21: 37-65, 1985):

Whitt and Yago argue that balanced transportation never developed in the United States because consumer options and spatial densities were illegitimately manipulated by an auto-oil-rubber complex. On this basis they criticize the conventional technology-efficiency hypothesis. This comment reviews the principal arguments and sources of evidence offered by Whitt and Yago. Their arguments presume that balanced transportation is feasible and desirable in the United States simply because it exists in Europe, rest on theoretical assumptions of class struggle and rational planning which are not demonstrated, and become internally contradictory in comparing the U.S. and European cases. Because the authors blend together political and economic analysis, evaluation of transportation options winds up depending on whose class interests an investigator proposes to favor. They therefore side-step the methodological problems of ever demonstrating the superiority of balanced transportation, since its existence in Europe ...
Optical Detection of Band Gap Variations Due to Ordering in Ga0.47In0.53As on InP

A reduction in the optical energy gap of more than 65 meV has been observed in In0.53Ga0.47 As grown on (100) InP by atmospheric pressure metalorganic vapor phase epitaxy. The band gap energies were deduced from room temperature photocurrent spectroscopic measurements, accounting for differences in composition and strain. Spontaneous CuPt type ordering of In and Ga atoms on the (111) subplanes of the InGaAs2 was confirmed by transmission electron microscopy. Superlattice signatures in the transmission micrographs were observed only for samples with associated reduced band gap energies, and were confirmed by visible double periodicity in high resolution images. In0.53Ga0.47 As was grown under a variety of conditions, some which promoted ordering. In general, lower growth temperatures and moderate (:_4 fum/hr) growth rates promoted a greater degree of ordering and reduction of the band gap energy. The influence of growth conditions on the ordered structure is considered within the context of current theories.
Cultural Tourism and Complex Histories: The Armenian Akhtamar Church, the Turkish State and National Identity

This article explores the ways states manage their national identity through cultural tourism policy. It draws on archival and ethnographic data on the opening of the Armenian Akhtamar Church in Turkey to cultural tourism and religious service for the first time after 95 years. Based on narrative evidence from the disputes among various actors with conflictual constructions of history, I find that states can use cultural tourism to produce multiple articulations of national identity and govern these articulations in accordance with their interests. The presence of multiple stages of tourism policy and the time and space bounded nature of interaction at each stage allow for the production of multiple images in different interaction situations. At the same time, the discourse of economic development associated with cultural tourism allows state actors to insulate themselves from criticism in disputes over national identity. The article shows how states use cultural tourism to create national identity even in the case of complex histories.
A r (Ω)-Weighted Imbedding Inequalities for A-Harmonic Tensors

We prove the basic A r (Ω)-weighted imbedding inequalities for A-harmonic tensors. These results can be used to estimate the integrals for A-harmonic tensors and to study the integrability of A-harmonic tensors and the properties of the homotopy operator T: C ∞(D,∧ l )→C ∞(D,∧ l−1).
Documentation of Safe Work Practices in the Clinicai Laboratory

The safety manual supplemented by explicit safety statements in the laboratory procedure manual should specify the hazards and containment methods for personnel. Control of fire hazards, biohazards, and chemical hazards are specifically addressed along with waste management and radionuclide consideration. Suggestions for incorporation of safety training into the laboratory’s continuing education program are provided.
Impact of state medicaid expansion status on length of stay and in‐hospital mortality for general medicine patients at US academic medical centers

BACKGROUND Medicaid is often associated with longer hospitalizations and higher in-hospital mortality than other insurance types. OBJECTIVE To characterize the impact of state Medicaid expansion status under the Affordable Care Act (ACA) on payer mix, length of stay (LOS), and in-hospital mortality. DESIGN/SETTING/PATIENTS Retrospective cohort study of general medicine patients discharged from academic medical centers (AMCs) within the University HealthSystem Consortium from October 1, 2012 to September 30, 2015. INTERVENTION/MEASUREMENTS Hospitals were stratified according to state Medicaid expansion status. The proportion of discharges by primary payer, LOS index, and mortality index were compared between Medicaid-expansion and nonexpansion hospitals before and after ACA implementation. ACA implementation was defined as January 1, 2014, for all states except Michigan, New Hampshire, Pennsylvania, and Indiana, which had unique dates of Medicaid expansion. RESULTS We identified 3,144,488 discharges from 156 hospitals in 24 Medicaid-expansion states and Washington, DC, and 1,114,464 discharges from 55 hospitals in 14 nonexpansion states during the study period. Hospitals in Medicaid-expansion states experienced a significant 3.7% increase in Medicaid discharges (P = 0.013) and a 2.9% decrease in uninsured discharges (P < 0.001) after ACA implementation, whereas hospitals in nonexpansion states saw no significant change in payer mix. In a difference-in-differences analysis, the changes in LOS and mortality indices pre- to post-ACA implementation did not differ significantly between hospitals in Medicaid-expansion versus nonexpansion states. CONCLUSIONS The differential shift in payer mix between Medicaid-expansion and nonexpansion states under the ACA did not influence LOS or in-hospital mortality for general medicine patients at AMCs in the United States. Journal of Hospital Medicine 2016. © 2016 Society of Hospital Medicine
The Conducted Electrical Weapon: Historical Overview of the Technology

Over the years, there have been many types of conducted electrical weapons (CEWs) in society. Historically, they were initially designed for direct, personal contact as a means of self-defense. Over time, they have changed with technology advances that allow several of them to be applied from some distance. Continued progression of the technology indicates that newer generation CEWs are now filled with advanced features such as multiple deployment capability or event data recording.
The Influence of Residential Status on the Adjustment to College at Four Urban Universities

College student adjustment, success, and retention have been a focus of college administrators and student development professionals for decades. However, national college retention and graduation ...
Influence of Abiotic Factors on Flight Initiation by Asian Citrus Psyllid (Hemiptera: Liviidae).

Predicting the emergence and arrival of insect pests is paramount for integrated pest management. To achieve this goal, it is important to understand how abiotic factors influence pest dispersal behavior. We investigated the effects of abiotic conditions on flight initiation by the Asian citrus psyllid, Diaphorina citri Kuwayama. We first explored the effect of barometric pressure changes on flight initiation. We used a custom-made barometric chamber and observed the activity of D. citri as measured by the number of psyllids captured on yellow cardboard panels coated with adhesive. We found that psyllid flight initiation changed in response to variations in barometric pressure rather than to differences in stable pressures. Diaphorina citri were equally active at 1,009 mbar and 1,022 mbar. However, D. citri dispersed more as barometric pressure increased, and less when barometric pressure decreased. In a subsequent experiment, we manipulated temperature and relative humidity and observed how D. citri dispersed between citrus plants. Psyllids dispersal increased linearly with temperature. Changes in humidity did not affect dispersal of D. citri. Less than 1% of psyllids dispersed at 15 °C, compared with 7.7% at 21 °C and 27% at 25 °C. The minimal threshold for D. citri to initiate flight is estimated to be 16.5 °C. Collectively, our results provide an initial step toward developing predictive models of D. citri movement as influenced by abiotic factors.
Community action and climate change

President Obama's rejection of the Keystone XL pipeline in 2015 established the viability of grassroots mobilization modelled on the social movement organization Bold Nebraska. This set a precedent for communities fighting energy projects that threaten natural resources and contribute to climate change.
Regulation of tumor suppressor NKX3.1 by ubiquitination

B57 Prostate cancer is the second leading cause of cancer deaths and the most frequently diagnosed malignancy in American men. The NKX3.1 gene located at 8p21.2 encodes a homeodomain-containing transcription factor that has been extensively studied for its prostate-restricted expression and its role in prostate cancer. Diminished expression of NKX3.1 protein has been observed in focal prostatic atrophy, prostatic intraepithelial neoplasia and prostate carcinoma. Nevertheless, the extent of NKX3.1 loss measured by immunostaining in these lesions varies among patient samples, and the correlation between NKX3.1 mRNA and protein level is poor. We identified multiple ubiquitin E3 ligases that target NKX3.1 for degradation in prostate cancer cells. We hypothesize that NKX3.1 and these E3 ligases in combination may be used as biomarkers for prostate cancer.
In operando infrared spectroscopy of lithium polysulfides using a novel spectro-electrochemical cell

Abstract A new in operando spectro-electrochemical Li-S cell has been demonstrated. The novel design allows investigations of the liquid electrolyte phase, in a commercial coin cell geometry, at C rates much higher than conventional in situ cells. We use ATR FT-IR spectroscopy, coupled with a previously developed polysulfide diagnostic to quantify the evolution of lithium polysulfides during the discharge and charge cycles of a Li-S cell. The trends observed in the polysulfide order and concentration with respect to state of charge are consistent with prevailing understanding of the electrochemical mechanisms of Li-S battery operation. During discharge, we observe the reduction of elemental sulfur to dissolved Li 2 S 8 polysulfides, and their cascading conversion to smaller polysulfides until insoluble species ( Li 2 S 2 and Li 2 S ) are formed. During cell charging, we observe the oxidation of insoluble polysulfides to larger, soluble polysulfides ( Li 2 S n , n > 3 ), and infer an eventual recovery of crystalline sulfur, from changes in polysulfides. Long-term evolution of polysulfides is observed over 7 discharge/charge cycles. Capacity fading is evident in the decay of polysulfide order and concentration at the same state of charge between cycles. Sulfur is not recovered by charging the cell in the latter cycles, and the active material is lost as solid Li 2 S .
Proton pump inhibitors and the risk of severe cognitive impairment: The role of posttraumatic stress disorder.

Introduction Proton pump inhibitors (PPIs), a common treatment for gastroesophageal reflux disease (GERD), were recently associated with increased risk of dementia. However, severe or chronic stress including, for example, posttraumatic stress disorder (PTSD) was not accounted for. This study examined whether PPI use was associated with severe cognitive impairment (SCI) and whether PTSD explained this association in a cohort of World Trade Center (WTC) responders. Method A prospective cohort study of 3779 WTC responders attending a university-based monitoring and treatment program. Prescriptions for PPIs and SCI determined using the Montreal Cognitive Assessment were the focus of the analysis. Results Overall, 1451 (38.4%) responders were dispensed PPIs, and 83 (2.2%) had SCI. Bivariable analyses revealed significant associations between being-dispensed PPIs in relation to SCI. After adjusting for PTSD, major depressive disorder, WTC exposures, age, and sex, being-dispensed PPIs were significantly associated with odds of SCI (adjusted odds ratio = 1.67 95% confidence interval = 1.054-2.643). Conclusions Being-dispensed PPIs were associated with SCI in this analysis of WTC responders. Results suggest that clinicians treating GERD seek to both understand patients' mental health history and monitor cognitive functioning when designing treatment routines. Overall, results confirmed that this is an important area of investigation with potential direct clinical implications.
Multiple Applications of a Transient CRISPR-Cas9 Coupled with Electroporation (TRACE) System in the Cryptococcus neoformans Species Complex

Cryptococcus neoformans is a fungal pathogen that claims hundreds of thousands of lives annually. Targeted genetic manipulation through biolistic transformation in C. neoformans drove the investigation of this clinically important pathogen at the molecular level. Although costly and inefficient, biolistic transformation remains the major method for editing the Cryptococcus genome as foreign DNAs introduced by other methods such as electroporation are predominantly not integrated into the genome. Although the majority of DNAs introduced by biolistic transformation are stably inherited, the transformation efficiency and the homologous integration rate (∼1–10%) are low. Here, we developed a Transient CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 coupled with Electroporation (TRACE) system for targeted genetic manipulations in the C. neoformans species complex. This method took advantages of efficient genome integration due to double-strand breaks created at specific sites by the transient CRISPR-Cas9 system and the high transformation efficiency of electroporation. We demonstrated that TRACE can efficiently generate precise single-gene deletion mutants using the ADE2 locus as an example. This system can also effectively delete multiple genes in a single transformation, as evident by the successful generation of quadruple mfα1Δ2Δ3Δ4Δ mutants. In addition to generating gene deletion mutants, we complemented the ade2Δ mutant by integrating a wild-type ADE2 allele at the “safe haven” region (SH2) via homologous recombination using TRACE. Interestingly, introduced DNAs can be inserted at a designated genetic site without any homologous sequences, opening up numerous other applications. We expect that TRACE, an efficient, versatile, and cost-effective gene editing approach, will greatly accelerate research in this field.
Privileged (Default) Causal Cognition: A Mathematical Analysis.

Causal cognition is a key part of human learning, reasoning, and decision-making. In particular, people are capable of learning causal relations from data, and then reasoning and planning using those cognitive representations. While there has been significant normative work on the causal structures that ought to be learned from evidence, there has been relatively little on the functional forms that should (normatively) be used or learned for those qualitative causal relations. Moreover, empirical research on causal inference learning causal relations from observations and interventions has found support for multiple different functional forms for causal connections. This paper argues that a combination of conceptual and mathematical constraints leads to a privileged (default) functional form for causal relations. This privileged function is shown to provide a theoretical unification of the widely-used noisy-OR/AND models and linear models, thereby showing how they are complementary rather than competing. This unification thus helps to explain the diverse empirical results, as these different functional forms are "merely" special cases of the more general, more privileged function.
Cytosolic Delivery of Multidomain Cargos by the N Terminus of Pasteurella multocida Toxin.

ABSTRACT The zoonotic pathogen Pasteurella multocida produces a 146-kDa modular toxin (PMT) that enters host cells and manipulates intracellular signaling through action on its Gα protein targets. The N terminus of PMT (PMT-N) mediates cellular uptake through receptor-mediated endocytosis, followed by the delivery of the C-terminal catalytic domain from acidic endosomes into the cytosol. The putative native cargo of PMT consists of a 710-residue polypeptide with three distinct modular subdomains (C1-C2-C3), where C1 contains a membrane localization domain (MLD), C2 has an as-yet-undefined function, and C3 catalyzes the deamidation of a specific active-site glutamine residue in Gα protein targets. However, whether the three cargo subdomains are delivered intact or undergo further proteolytic processing during or after translocation from the late endosome is unclear. Here, we demonstrate that PMT-N mediates the delivery of its native C-terminal cargo as a single polypeptide, corresponding to C1-C2-C3, including the MLD, with no evidence of cleavage between subdomains. We show that PMT-N also delivers nonnative green fluorescent protein (GFP) cargo into the cytosol, further supporting that the receptor-binding and translocation functions reside within PMT-N. Our findings further show that PMT-N can deliver C1-C2 alone but that the presence of C1-C2 is important for the cytosolic delivery of the catalytic C3 subdomain by PMT-N. In addition, we further refine the minimum C3 domain required for intracellular activity as comprising residues 1105 to 1278. These findings reinforce that PMT-N serves as the cytosolic delivery vehicle for C-terminal cargo and demonstrate that its native cargo is delivered intact as C1-C2-C3.
The Wide Area Virtual Environment: A New Paradigm for Medical Team Training

Medical simulation can provide safe, consistent, and repeatable learning opportunities to learners without risk to patient safety. There is an increasing awareness of the value that simulation brings to learning. The Wide Area Virtual Environment (WAVE) is an 8,000 sq. ft. facility designed to provide an immersive virtual environment for medical team training. It combines computer generated 3D stereoscopic images, standardized patients, human patient simulators and theatrical effects to render training scenarios with an unprecedented level of realism. The WAVE represents a novel application of human-computer interaction. It forms the basis for a synergistic amalgamation of live, virtual, and constructive simulation for medical instruction. In this paper, we discuss the design, construction, and use of the WAVE.
Quantitative BCR-ABL1 RQ-PCR Fusion Transcript Monitoring in Chronic Myelogenous Leukemia

The reciprocal Philadelphia translocation between chromosomes 9 and 22 [t(9;22)(q34;q11)] creates a BCR-ABL1 fusion protein that occurs in approximately 95% of cases of chronic myelogenous leukemia (CML), 15% of cases of adult acute lymphoblastic leukemia, and 5% of adult cases of acute myeloid leukemia. The BCR-ABL1 protein is a constitutively activated tyrosine kinase that induces and maintains the neoplastic phenotype in these leukemias. PCR-based methods to identify and quantitate the tumor-specific BCR-ABL1 RNA have been shown to be an ultrasensitive diagnostic/prognostic tool for Philadelphia-positive leukemias. A novel tyrosine kinase inhibitor (TKI), imatinib, has been confirmed as an effective targeted treatment in most CML patients. A consensus goal for TKI treatment is to achieve a major molecular response (MMR), defined as a 3-log (1,000-fold) reduction in BCR-ABL1 transcripts. Patients who achieve an MMR have been shown to have a significantly reduced risk of disease progression. Conversely, increasing post-therapy BCR-ABL1 RNA levels convey a significantly increased risk of disease progression. The early identification of these high-risk patients may allow early changes to the therapeutic strategy, before frank relapse. Thus, quantitative measurement of BCR-ABL1 transcripts in blood and bone marrow both aids in the initial diagnosis of CML and is essential for routine post-therapy minimal residual disease monitoring. We describe here a method for quantitating BCR-ABL1 transcripts in peripheral blood or bone marrow of CML patients using real-time quantitative reverse transcription PCR (RQ-PCR).
New brewing technologies: setting the scene.

Publisher Summary This chapter provides some underpinning information regarding new brewing technologies. It presents basic summaries of the processes involved in malting and brewing and the importance of each unit operation. The larger proportion of the world's beers is produced from malted barley. It has been this way for perhaps 8000 years. Barley has been retained as the primary cereal of choice, not least because it retains its husk on threshing and this traditionally forms the filter bed through which wort is collected in the brew house. Although there are beers that are produced only from malted barley, for example, those produced under the terms of the five-centuries-old Bavarian “purity” law, the Reinheitsgebot, many brewers employ various adjuncts for reasons of quality (different colors, better foams, interesting flavors) or cost. The chapter discusses these other materials used in brewing. It also highlights miscellaneous process ingredients that may be employed in brewing. Cost is only one of the drivers influencing business decisions in the brewing industry. Other major forces are quality, product safety and wholesomeness, product innovation to foster new global market opportunities and environment.
From Powerhouses to Pixies and Back: Boys, Men, and Troubled Masculinity in Artistic Gymnastics

Gymnastics, as Natalie Barker-Ruchti (2008) notes, has been described as the sport of pixies since Olga Korbut’s emergence on the world stage in the 1970s. Implicit in this claim is the notion that gymnastics is a sport for women and girls. Contrary to this public perception, men and boys have participated in modern gymnastics competitions since the nineteenth century, decades before women were allowed to compete in the elite ranks of the sport. This misperception creates a conundrum for boys and men who participate in what is still often perceived as a girls’ sport (Schmalz & Kerstetter, 2006). How has the tension between gymnastics participation and masculinity been created and maintained among its participants, administrators, and spectators, and how is this tension manifest today? To address these questions and the theoretical concerns underlying them, this chapter does the following: (1) explores ideas about masculinity expressed about the burgeoning men’s gymnastics programs in Europe in the twentieth century, (2) analyzes competition regulations that purport to minimize differences between men’s and women’s performances while simultaneously highlighting the supposedly inherent differences between male and female bodies, and (3) critically examines media practices that constitute male gymnast bodies within frameworks of compulsory heterosexuality and traditional manhood, thereby “protecting” those bodies—and the sport itself—from charges of failed masculinity, to use Jack Halberstam’s (2011) term. I argue that, because of the fraught relationship between men’s gymnastics and its somewhat more popular women’s counterpart, male gymnasts occupy a precarious position in the public imagination, a position from which their bodies serve as a repository for anxieties about unstable gender norms.
Validation of an alcohol misuse classifier in hospitalized patients

Abstract Background Current modes of identifying alcohol misuse in hospitalized patients rely on self-report questionnaires and diagnostic codes that have limitations, including low sensitivity. Information in the clinical notes of the electronic health record (EHR) may further augment the identification of alcohol misuse. Natural language processing (NLP) with supervised machine learning has been successful at analyzing clinical notes and identifying cases of alcohol misuse in trauma patients. METHODS: An alcohol misuse NLP classifier, previously developed on trauma patients who completed the Alcohol Use Disorders Identification Test, was validated in a cohort of 1000 hospitalized patients at a large, tertiary health system between January 1, 2007 and September 1, 2017. The clinical notes were processed using the clinical Text Analysis and Knowledge Extraction System. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) guidelines for alcohol misuse were used during annotation of the medical records in our validation dataset. RESULTS: The alcohol misuse classifier had an area under the receiver operating characteristic curve of 0.91 (95% CI 0.90–0.93) in the cohort of hospitalized patients. The sensitivity, specificity, positive predictive value, and negative predictive value were 0.88 (95% CI 0.85–0.90), 0.78 (95% CI 0.74–0.82), 0.85 (95% CI 0.82–0.87), and 0.82 (95% CI 0.78–0.86), respectively. The Hosmer–Lemeshow Test (p = 0.13) demonstrates good model fit. Additionally, there was a dose-dependent response in alcohol consumption behaviors across increasing strata of predicted probabilities for alcohol misuse. CONCLUSION: The alcohol misuse NLP classifier had good discrimination and test characteristics in hospitalized patients. An approach using the clinical notes with NLP and supervised machine learning may better identify alcohol misuse cases than conventional methods solely relying on billing diagnostic codes.
Libet's intention reports are invalid: A replication of Dominik et al. (2017)

In the "Libet experiment" the onset of movement-related brain activity preceded the reported time of the conscious intention to move, suggesting that conscious intention may not play a role in initiating voluntary movements (Libet, Gleason, Wright, & Pearl, 1983). Dominik et al. (2017) provided evidence that the intention reports employed in the Libet experiment, which Libet et al. (1983) found to precede movement reports, are invalid. In the study by Dominik et al., intention reports preceded movement reports only when participants had prior experience making movement reports. Individuals without such experience reported intention around the same time as movement. These findings suggest that Libet's intention reports do not reflect experiences of intention, but, rather, inferences based on prior experience with movement reports. Our study replicated the core findings of Dominik et al. We argue that Libet's intention reports are invalid and explore the phenomenology of intention in the Libet experiment.
Compact Microstrip Patch Antennas on 3-D Printed Substrates with Dielectric Loading

In this paper, dielectric loading with a high dielectric constant material is investigated for the design of a compact, inset-fed patch antenna using a hybrid 3-D printing approach. Two loading patterns are presented that allow the reduction of the antenna’s resonant frequency without increasing its size. Using the substrate loading configurations developed, a resonant frequency identical to that of a purely high dielectric substrate (42% drop from 2.44 GHz to 1.39 GHz) is realized, with a 2 to 4 dB improvement in gain compared to that of the purely high dielectric substrate. Moreover, when compared to the conventional approach to increasing antenna size in order to achieve the same 42% drop in frequency, this design offers a 66% reduction in surface area. The low cost and ease of manufacture furthermore renders these patterns useful to realize compact patch antennas while maintaining good RF performance, thereby offering increased design flexibility.
Clinical outcomes of multiple myeloma patients who undergo autologous hematopoietic stem cell transplant with G-CSF or G-CSF and plerixafor mobilized grafts.

Impact of Plerixafor (P) mobilized stem cells on immune reconstitution, such as absolute lymphocyte count at day 30 (ALC30), and on long-term outcomes of Multiple Myeloma (MM) patients undergoing autologous stem cell transplant (ASCT) has not been well established. We evaluated total of 469 patients mobilized with G-CSF (G) alone, and 141 patients mobilized with G-CSF plus plerixafor (G+ P). Patients only received plerixafor if they had peripheral blood CD34+ blood count <20/μL on first planned day of collection. Primary endpoint, ALC30, was 1.3 K/μL (range, 0.1-4.5) and 1.2 K/μL (range, 0.1-5.1) for G and G + P, respectively (P =. 61). The median PFS was 2.5 years (95% CI, 2.1-3.2) and 2.8 years (95% CI, 2.0-3.3) for G and G + P, respectively (HR: 1.13; 95% CI, 0.84-1.50; P = .42). The median OS was 6.1 years (95% CI, 4.6-NR) for G group compared to 3.7 years (95% CI, 3.2-NR) for the G + P group (HR: 1.64; 95% CI, 1.12-2.40; P = .01). The median follow-up time for OS was 2.53 years (95% CI, 2.13-2.99) and 1.59 years (95% CI, 1.17-2.02) for G and G+ P group, respectively. In this large retrospective analysis of MM patients mobilized with G-CSF vs G-CSF + P, there was no significant difference in lymphocyte recovery or PFS. There was an overall survival difference in patients who were poor mobilizers and could not be mobilized with G-CSF alone.
Tolerability of neratinib in older adults with HER2 positive or HER2 mutated metastatic breast cancer.

e13018Background: The tolerability and efficacy of targeted therapy in older adults with cancer have not been adequately studied. Neratinib is an oral pan-HER1, HER2, and HER4 tyrosine kinase inhib...
Multi-Plane Image Video Compression

Multiplane Images (MPI) is a new approach for storing volumetric content. MPI represents a 3D scene within a view frustum with typically 32 planes of texture and transparency information per camera. MPI literature to date has been focused on still images but applying MPI to video will require substantial compression in order to be viable for real world productions. In this paper, we describe several techniques for compressing MPI video sequences by reducing pixel rate while maintaining acceptable visual quality. We focus on using traditional video compression codecs such as HEVC. While certainly a new codec algorithm specifically tailored to MPI would likely achieve very good results, no such devices exist today that support this hypothetical MPI codec. By comparison, hundreds of millions of real-time HEVC decoders are present in laptops and TVs today.
Linearization of Voltage-Controlled Oscillators Using Floating-Gate Transistors

This brief presents a linearization method for the voltage-to-current (V-to-I) stage of voltage-controlled oscillators (VCOs). A floating-gate transistor is utilized at the VCO’s input stage as a low-overhead method for V-to-I linearization. The resulting VCO is a ring oscillator with an extended linear voltage-to-frequency range. The ring oscillator VCO (RO-VCO) has also been included in a VCO-based analog-to-digital converter (VCO-ADC) to showcase how the linearization technique can be leveraged to improve system performance. The measured results from the linearized RO-VCO are compared to current state-of-the-art designs, and the VCO-ADC is compared to a standard architecture. The circuits were fabricated in a standard $0.35~\mu \text{m}$ complementary metal-oxide-semiconductor (CMOS) process.
Turkey’s queer times: epistemic challenges

This article suggests that Turkey’s queer times are co-constitutive with Jasbir Puar’s queer times of homonationalism. If the queer times of homonationalism correspond to a folding of some queers into life and respectability at the cost of rising Islamophobia in the “West,” Turkey’s queer times witnessed the increasing marginalization and “queering” of variously respectable subjects in the name of Islam and strong LGBT organizing against such marginalization. It discusses the epistemic challenges of studying Turkey’s queer times that stem from a theoretical suspicion that “queer” operates as a tool of colonial modernity when it spreads to the “non-West,” a suspicion that is due both to a perception of Islam as a target and victim of Western neocolonialism and to an ahistorical and rigidly discursive understanding of language. In turn, scholarship on Turkey’s queer times has the potential to truly transnationalize queer studies, both getting us out of the binaries of global–local, colonial–authentic, and West–East and reminding scholars that hegemonies are scattered.
Identification and Assessment of Physical Transportation Infrastructure Vulnerable to Sea Level Rise

The objective of this research was developing a methodology for assessing the potential impacts of sea level rise (SLR) on Florida’s state transportation infrastructure to assist the state with transportation planning. Rising temperatures lead to thermal expansion of the ocean and melting ice caps, both of which result in increased ocean level, making Florida among the most vulnerable areas in the world for climate change due its coastal proximity and low elevation. The proposed approach integrates the Florida Department of Transportation (FDOT) information system, satellite imagery, local roadway and hydrologic data with existing topographical and geographical data to generate SLR projections to facilitate i) the evaluation of current and projected SLR impacts on transportation infrastructure located along Florida’s coastline and low-lying terrain areas, and ii) the identification of the physical transportation infrastructure components that are vulnerable given the United States Army Corps of Engineers’ scenario-based methodology to project the timing of future low, intermediate and high rates of sea level change. A detailed case study in Dania Beach, Florida and a comparative example in Punta Gorda, Florida were used to evaluate the soundness of the methodology. Further research was performed to develop a preliminary evaluation of the impact of groundwater levels as an exacerbating factor with respect to sea level rise. Storm surge with SLR is a future, more difficult area of investigation. It is important to incorporate adaptive management processes into the planning as more information becomes available. Estimates of what these adaptive processes may cost were included for planning purposes. Priorities and sequence are local issues that need local input.
MEC in Action: Performance, Testing and Ecosystem Activities

We finally arrived at the end of this book. This last chapter is very important as it provides an overview of the many ongoing activities devoted to put MEC in the actual market, e.g. from performance assessment, to conformance testing, proof-of-concepts, hackathons and deployment trials.
Self-regulated growth of candidate topological superconducting parkerite by molecular beam epitaxy

Ternary chalcogenides, such as parkerites and shandites, are a broad class of materials exhibiting a rich diversity of transport and magnetic behavior and an array of topological phases, including Weyl and Dirac nodes. However, they remain largely unexplored as high-quality epitaxial thin films. Here, we report the self-regulated growth of thin films of the strong spin–orbit coupled superconductor Pd3Bi2Se2 on SrTiO3 by molecular beam epitaxy. Films are found to grow in a self-regulated fashion, where, in excess Se, the temperature and relative flux ratio of Pd to Bi control the formation of Pd3Bi2Se2 due to the combined volatility of Bi, Se, and Bi–Se bonded phases. The resulting films are shown to be of high structural quality, and the stoichiometry is independent of the Pd:Bi and Se flux ratio and exhibits a superconducting transition temperature of 800 mK and a critical field of 17.7 ± 0.5 mT, as probed by transport and magnetometry. Understanding and navigating the growth of the chemically and structurally diverse classes of ternary chalcogenides open a vast space for discovering new phenomena and enabling new applications.
True North: The Facts About the Canadian Mortgage Banking System

Given the relative stability of Canadian housing markets, many observers try to draw comparisons between the housing finance policies of Canada and the United States. Why is it that the United States suffered through such a painful housing bubble and bust in the last decade, while Canada did not? After all, the two countries enjoy relatively similar homeownership rates and share many other attributes. The answer, quite simply, is that Canada did not become enthralled with the laissez faire ideology that dominated U.S. economic policy making in the 2000s, and thus did not allow major gaps in its regulation of housing finance to develop.
An optimal multigrid algorithm for continuous state discrete time stochastic control

The application of multigrid methods to a class of discrete-time, continuous-state, discounted, infinite-horizon dynamic programming problems is studied. The authors analyze the computational complexity of computing the optimal cost function to within a desired accuracy of epsilon , as a function of epsilon and the discount factor alpha . Using an adversary argument, they obtain lower bound results on the computational complexity for this class of problems. They also provide a multigrid version of the successive approximation algorithm whose requirements are (as a function of alpha and epsilon ) within a constant factor from the lower bounds when a certain mixing condition is satisfied. Hence the algorithm is optimal. >
Stochastic Adaptive Control Algorithms Originally Designed for the Ideal System Models are Robust with Respect to Unmodeled Dynamics and External Disturbances

Originally adaptive control theory was developed for the ideal system models, i.e., linear system models under the assumption that relative degree and upper bounds on the order of the systems are known. At the beginning of the last decade, adaptive control algorithms designed for such ideal system models were strongly attacked by many researchers due to "lack of robustness" in the presence of unmodeled dynamics and external disturbances. The purpose of the present paper is to relax existing constant pressure on the adaptive control algorithms originally designed for the ideal system models. It is shown that such adaptive control algorithms are globally stable and robust with respect to unmodeled dynamics and external disturbances without any modifications, such as ?-modification, e 1 -modification, relative dead-zone, projection of the parameter estimates, etc. The essential for establishing the global stability of the unmodified algorithms is to understand and mathematically formalize self-stabilization mechanism which is naturally inherent to such algorithms.
A Geostatistical Data Assimilation Approach for Estimating Groundwater Plume Distributions from Multiple Monitoring Events

Knowledge of the distribution of groundwater contaminant plumes is needed to avoid pumping contaminated water, assess past exposure to contamination, and design remediation schemes to contain or treat the contaminated area. In most field cases, however, contamination is discovered by a small number of fortuitously located wells, and the full distribution of the plume is never known. This paper presents a stochastic geostatistical data assimilation approach capable of estimating the plume distribution at any time before, during or after the monitoring history of a site. The approach uses concentration data from all available monitoring events and results in plume estimates that are also consistent with groundwater flow and transport at the affected site. One of the unique features of the approach is that measurements taken at times subsequent to the time for which the plume is to be estimated can be used as an additional constraint on the plume distribution. The method is demonstrated using two hypothetical examples. In the first example, the distribution of a plume is estimated based on multiple sampling events from a sparse monitoring network. In the second example, the plume distribution is recovered using temporal breakthrough curves from downgradient monitoring wells.
Back to the Future?: Emergent Visions for Object‐Based Teaching in and beyond the Classroom

This article introduces a special issue of Museum Anthropology devoted to innovative strategies for teaching with objects. Although a century ago anthropology, museums, and objects were intimately entwined, trends in many museology and anthropology courses have drifted toward focusing on ideas and people rather than objects. The contributors to this special issue have cultivated new pedagogical approaches that complement or realign literature-focused classroom canons that can distance students from the very objects under study. In keeping with recent theoretical approaches to objects that highlight the sensory dimensions of material culture, many of the articles in this special issue examine the challenges and potential rewards when educators foster physical engagement with objects in and beyond the classroom. Taken together, the articles also underscore how object-based teaching can yield new theoretical and practical insights, enhance the social relevance of classroom activities, and facilitate meaningful benefits for local communities. [material culture, praxis, pedagogy, embodied practices, object-based teaching]
Modulation of sulfur mustard induced cell death in human epidermal keratinocytes using IL‐10 and TNF‐α

We compared the effects of overexpressing a tightly regulated anti-inflammatory cytokine, interleukin 10 (IL-10), and the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) on sulfur mustard induced cytotoxicity in human epidermal keratinocytes. Both cytokines were overexpressed when compared with the cells transfected with the empty vector as determined by quantitative ELISA. Cells overexpressing interleukin 10 suppressed the pro-inflammatory cytokines interleukin 8 and interleukin 6 following exposure to 50–300 μM sulfur mustard. These cells exhibited delayed onset of sulfur mustard induced cell death. On the other hand, cells overexpressing tumor necrosis factor alpha induced a sustained elevation in both interleukin 6 and 8 expression following exposure to 50–300 μM sulfur mustard. These cells were sensitized to the effects of sulfur mustard that resulted in an increased sulfur mustard induced cell death. Normal human epidermal keartinocytes treated with sulfur mustard exhibited elevated levels of tumor necrosis factor alpha expression and increased activity of nuclear factor kappa B. Gene array data indicated that cells overexpressing interleukin 10 induced several genes that are involved in growth promotion and cell-fate determination. We, therefore, identify IL-10 and TNF-α signal transduction pathways and their components as possible candidates for early therapeutic intervention against sulfur mustard induced cell injury. © 2005 Wiley Periodicals, Inc. J Biochem Mol Toxicol 19:213–225, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.20089
Clock Generation and Distribution of a Dual-Core Xeon Processor with 16MB L3 Cache

The clock generation and hybrid clock distribution for a dual-core Xeonreg processor with 16MB L3 cache are designed for <11ps global clock skew in a 435mm2 die. The cache and control sections contain 2 primary clock domains and 11 clock spines. A pipelined de-skew logic tolerant to inter-domain clock uncertainties manages the core and cache/control data communication