cssi/SciSciGPT-SciSciNet huggingface dataset:
Sequence of the MIR-1 β-Lactamase Gene

The complete nucleotide sequence of the plasmid-mediated MIR-1 β-lactamase gene confirms its relationship to chromosomally located ampC genes of Enterobacter cloacae. blaMIR-1 is not part of a typical gene cassette but does lie near an element that could be involved in its capture on a plasmid.
TRANSESOPHAGEAL COLOR FLOW DOPPLER AND ECHOCARDIOGRAPHIC FEATURES OF NORMAL AND REGURGITANT ST. JUDE MEDICAL PROSTHESES IN THE AORTIC VALVE POSITION

Abstract Transthoracic echocardiography and color flow Doppler have been shown to be of value in evaluating regurgitant St. Jude Medical (SJM) prostheses in the aortic valve position. 1 These studies have emphasized the limitations of this technique in diagnosing SJM mitral regurgitation because of flow masking and signal attenuation produced by the echo-reflective metallic valves. 2 Transesophageal echocardiography and color flow Doppler overcome these problems and show promise in evaluating normal functioning and regurgitant SJM mitral valves. 3,4 This report describes our transesophageal ultrasound experience with 28 normal functioning and 8 regurgitant SJM prostheses in the mitral valve position.
Detecting novel fault conditions with hidden Markov models and neural networks

Publisher Summary This chapter presents the detection of novel fault conditions with hidden Markov models and neural. Fault detection and isolation for the antennas is often a complicated and lengthy process because of the fact that it can be difficult to establish the root cause of a problem in the communications chain. Loss of a spacecraft signal during a planetary encounter can result in the irretrievable loss of scientific data. Hence, there is considerable motivation to be able to quickly detect and isolate anomalous conditions. Similar scenarios occur in other applications, such as industrial plant process monitoring, biomedical health monitoring, and on-board vehicle fault diagnosis. A key point in the Markov monitoring approach is that the transition probabilities are not estimated from the data but rather are chosen a priori based on the long-term temporal characteristics of the system and prior knowledge concerning the system failure modes. In speech modelling, estimation algorithms are used to estimate the probabilities through maximum likelihood methods directly from data.
Evaluation of success criteria in job search: A process perspective.

Job-search studies possess a disturbing lack of consistency in the operationalization of search success. This prevents researchers from attaining their goal of explaining and predicting the use of job information sources and search activities. In the current study, we examined two theoretical models that depicted structural relations among nine success criteria often employed in the job-search literature. Overall, the criteria are weakly related to each other. The findings suggest the importance of careful consideration of the meaning and process of job-search success criteria, and that these issues should not be further overlooked.
Relative abundance of Sepkoski's evolutionary faunas in Cambrian–Ordovician deep subtidal environments in North America

The relative proportions of Sepkoski's Cambrian, Paleozoic, and Modern evolutionary faunas in Cambrian-Ordovician benthic marine assemblages from mixed carbonate-shale and shale lithofacies deposited below normal wave base (herein, deep subtidal) in North America are strongly positively correlated with global relative genus richness in Sepkoski's global compendium. The correlation between local and global faunal proportions is robust regardless of how propor- tions are calculated, including when local proportions are based on number of specimens. Like the global pattern, the transition between the Cambrian and Paleozoic evolutionary faunas appears to occur gradually, in that Lower Arenigian (Ibexian) deep subtidal assemblages contain approxi- mately equal proportions of Cambrian and Paleozoic faunal elements. In agreement with previous work, an onshore-offshore differentiation of faunas is evident both within Ordovician deep subtidal communities and across a larger environmental gradient. Within the deep subtidal assemblages studied here, the Paleozoic fauna tends to have a greater proportion of individuals for a given proportion of genera than the Cambrian fauna, although both tend to accrue genera at similar rates with increasing relative abundance. The Modern evolutionary fauna appears to accrue genera more rapidly with increasing local relative abundance. The extent to which these differences reflect ecological factors such as biomass, metabolic requirements or larval recruitment patterns, taxonomic practices stemming from variable morphospace saturation, or taphonomy-related counting biases remains unclear, but it suggests the possibility that Sepko- ski's evolutionary faunas may share ecological characteristics that influence both local relative abundance and global rates of taxonomic evolution.
Platelets and factor XI bypass the contact system of blood coagulation.

Introduction: Factor XI is a plasma glycoprotein (concentration ~30 nM) that was first identified by Rosenthal et al1 as a plasma coagulation factor deficiency in patients with abnormal hemostasis, particularly common among Ashkenazi Jews.2,3 In spite of recent advances in our understanding of the structure of factor XI and its gene, the structure-function relationships of the protein, and the molecular genetics of factor XI deficiency, considerable confusion about the physiologic role and clinical relevance of factor XI has arisen from both clinical and biochemical observations. One problem arises from the fact that, until recently, the only known pathway for activation of factor XI involved proteolytic activation by factor XIIa and interactions with coagulation proteins of the contact phase of blood coagulation.4-7 The problem arose from the clinical observation that patients with deficiencies of factor XI are subject to bleeding complications, whereas patients with deficiencies of the contact proteins are not.2,3,8-13 A related unanswered question concerns the lack of correlation in many reported patients between plasma levels of factor XI and the severity of clinical bleeding manifestations.2,3,8,9,13-15 In addition, some patients with severe factor XI deficiency experience significant bleeding complications, whereas others appear to be hemostatically normal. These clinical and biochemical observations have motivated investigations focused on alternative mechanisms for activation of factor XI independent of contact phase protein.19-22 Additional studies have focused on the identification and characterization of platelet factor XI, which is postulated to be an alternative splicing product of the factor XI gene. Platelet factor XI is present in platelet membranes and might substitute for plasma factor XI in hemostasis and account for the absence of bleeding complications in some patients with severe plasma factor XI deficiency.14,16-18,23-26 Studies addressing these two important and related problems are presented and discussed in this chapter.
Abstract P6-10-14: Association between mammographic breast density and histologic features of benign breast disease

Background: Mammographic breast density (MBD) reflects the proportion of fibroglandular tissue in the breast, and is an established risk factor for breast cancer. Benign breast disease (BBD) is also a known risk factor for breast cancer. We previously showed an association between lobular involution (physiologic atrophy) and MBD in a large cohort study of women with BBD. We performed a comprehensive evaluation of the association of histologic features of BBD with MBD. Methods: The Mayo BBD cohort includes women, 18 to 85 years, who were diagnosed with BBD at Mayo Clinic in Rochester, MN between 01/01/1967 and 12/31/1991. For this study, we included women who had a mammogram within 6 months of BBD diagnosis, and diagnosed with BBD between 1985 and 1991 when parenchymal pattern of breast density was clinically recorded. Risk factor information such as age, and body mass index (BMI) was collected from medical records. Parenchymal pattern, assessed clinically and previously used in multiple studies of MBD and risk, classified breast density based on extent and type of density, into four categories: N1 (non-dense, no ducts visible); P1 (ductal prominence occupying 25% of the breast; DY (homogenous plaque-like areas of density). All assessments of benign breast tissue were performed by expert breast pathologists blinded to both MBD and BBD reports. Histologic characteristics included overall impression (non-proliferative disease (NPD), proliferative disease without atypia (PDWA), and atypical hyperplasia (AH)), proportion of normal lobules that were involuted (no (0%), partial (1 to 74%), or complete (≥75%)), type of AH (ADH or ALH), ductal and lobular hyperplasia, calcifications, sclerosing adenosis, columnar alteration, cyst, fibroadenoma, marked fibrosis, intra-ductal papilloma, radial scar (number and size), duct ectasia, and mucocele like tumors. Associations of parenchymal pattern with BBD characteristics were examined using multicategorical nominal logistic regression models. We first examined associations after adjustment for age and BMI. All variables statistically significant (p Citation Format: Karthik Ghosh, Robert A Vierkant, Ryan D Frank, Daniel W Visscher, Vernon S Pankratz, Christopher G Scott, Derek C Radisky, Marlene H Frost, Lynn C Hartmann, Amy C Degnim, Celine M Vachon. Association between mammographic breast density and histologic features of benign breast disease [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P6-10-14.
Endometrial transport generates the maternal-fetal electrical potential difference in guinea pigs

These studies examined the transport characteristics of the uterine endometrium with respect to the origin and mechanism of generation of the maternal-fetal electrical potential difference (PD) in pregnant guinea pigs. Late-gestation animals were used in two experimental preparations. In vivo, a sealed uterine pouch that preserved blood flow to the endometrium was prepared by removal of the fetus, placenta, and fetal membranes from the uterus and replacement with Earle's solution, a balanced electrolyte solution. In vitro, sections of uterine wall comprised of myometrium and endometrium without fetal membranes were mounted in Ussing chambers. Transuterine PDs (fetal side negative) were indistinguishable in vivo and in vitro, averaging 29.6 +/- 4.5 and 32.6 +/- 6.1 (95% confidence interval) mV in the respective preparations. Both values are within the range of maternal-fetal PD measured in intact guinea pigs, indicating that the fetoplacental unit is not essential in generating an intrauterine PD. The maternal-fetal PD, therefore, is likely a passive result of the fetus and placenta being immersed in fluids at the intrauterine potential. In vitro, both PD and short-circuit current (Isc) were completely inhibited by ouabain (10(-3) M) at the serosal (maternal) side of the uterine wall but unaffected by the inhibitor from the luminal (fetal) side. Amiloride (10(-5) M) and valinomycin (10(-5) M) caused decreases in the PD when added to the luminal side, both in vivo and in vitro, and were both ineffective from the serosal side in vitro. Isc was reduced 83% from 315 +/- 24 to 53 +/- 6 (SE) microA/cm2 after luminal amiloride (5 x 10(-4) M), indicating that Na+ is the predominant ion actively transported.(ABSTRACT TRUNCATED AT 250 WORDS)
Sanitizer efficacy against attached bacteria in a milk biofilm

Pseudomonas fluorescens , Yersinia enterocolitica , and Listeria monocytogenes were shown to readily attach to both rubber and Teflon® surfaces. Sanitizer efficacy testing done in the laboratory with nonadherent bacteria could lead to false assumptions as to the sanitizer's true effectiveness under processing conditions where cells may be attached. The objectives in this study were: (a) evaluate the efficacy of in-use concentrations of sanitizers on bacteria attached to gasket materials, (b) compare bacterial attachment to rubber and Teflon® gaskets, (c) examine different methods of enumeration, and (d) compare sanitizer efficacy on attached and suspended bacteria. The goal reduction for all of the sanitizers tested was ≥3 log cycles or 99.9%. Results indicated that iodophor, hypochlorite, acid anionic, peroxyacetic acid, fatty acid, and quaternary ammonium sanitizers failed to provide an adequate reduction in the numbers of attached bacteria at levels of 104 to 105/mm2 in most cases. The test organisms attached in slightly higher numbers to the rubber surface versus Teflon®. Plate counts, impedance microbiology, and the direct epifluorescent filter technique were tested as methods of enumeration. Impedance microbiology was the best method of enumeration, since it allowed the estimation of both reversibly and irreversibly attached bacteria. The efficacy of sanitizers versus a bacterial suspensions resulted in a ≥ 5 log-cycle reduction. The same concentrations were relatively ineffective against the attached bacteria. The goal reduction was reached on the Teflon® surface with the iodophor, hypochlorite, and fatty acid sanitizers with a log-cycle reduction in the number of Yersinia enterocolitica of 3.09, 3.19, and 3.31, respectively. Pseudomonas fluorescens was reduced by 3.16 on both the rubber and Teflon® surfaces when exposed to the hypochlorite sanitizer.
Electronic Structure of Pure and Doped Cuprous Oxide with Copper Vacancies: Suppression of Trap States

Cuprous oxide (Cu2O) is an attractive material for solar energy applications, but its photoconductivity is limited by minority carrier recombination caused by native defect trap states. We examine the creation of trap states by cation vacancies, using first principles calculations based on density functional theory (DFT) to analyze the electronic structure and calculate formation energies. With several DFT-based methods, a simple vacancy is predicted to be consistently more stable than a split vacancy by 0.21 ± 0.03 eV. Hybrid DFT is used to analyze the density of states and charge density distribution, predicting a delocalized hole for the simple vacancy and a localized hole for the split vacancy, in contrast to previously reported results. The differing character of the two defects indicates that they contribute to conduction via different mechanisms, with the split vacancy as the origin of the acceptor states that trap minority carriers. We explore methods of improving photoconductivity by doping Cu2O ...
Dual Crossover Dual Shock Ignition of a Pulse Detonation Engine

A study has been done on the potential to ignite a detonation by reflected shock in a Pulse Detonation Engine (PDE) from another PDE over a wider range of crossover tube lengths with dual crossover tubes carrying the shock generated by a detonation. Frequency of firing was also varied to test viability at high frequencies and the dependence of detonation on frequency. Two main configurations of 2-crossover-tube PDE configurations were tested. One configuration was with parallel tubes, one downstream of the other. The other consisted of the same driver PDE configuration, but with a modified fitting allowing the two to converge at a single spot at the second PDE.
Comparative Study of Damage and Hysteretic Energy Characteristics of RC Continuous Girder Bridge Caused by Near-field and Far-field Strong Earthquake

Taking an expressway RC continuous girder bridge as the research object,the finite element model of the bridge considering nonlinear mechanical behavior of bridge piers is built. Selecting Typical near-fault and far-field strong earthquake records,the influences of frequency spectrum,peak acceleration( PGA),and duration on the values and distribution of hysteretic energy,structural damage is comparatively analysed by nonlinear time history integration method and key indexes extracted by self-programming. The study result shows that( 1) the frequency characteristics of ground motion has significant influence on the seismic response of bridge structure,and the increase of PGV / PGA will lead to significant augment of hysteretic energy and damage;( 2) at the same level of PGA and duration,the hysteretic energy and damage of the bridge piers under near-field earthquakes are far greater than those of far-field earthquakes, and the appearance position of damage is much higher;( 3) in certain region near the pier bottom,the proportions of hysteretic energy and damage under near-field earthquakes are less than those of far-field earthquakes,while the above indexes are greater than those under far-field earthquakes outside that scope,which shows thedistribution of hysteretic energy and damage under near-field earthquakes are much evener along piers. The comparison shows that near-field earthquake has more vigorous requirement of hysteretic energy and damage on bridge structure, and they expands upward along the pier height, which put forward much strict requirements for seismic design of bridge under this kinds of earthquake.
Study on recovery and lowest detection limit of Klebsiella determination in infant formular milk powder

Objective:To evaluate the recovery and the lowest detection limit of Klebsiella determination in infant formular milk powder by using domestic-developed MACI as medium.Methods: ATCC13182 and ATCC10031 were chosen as testing bacterial strains with NA as controls,recoveries were evaluated by coating them on MACI cultures and the lowest detection limits were obtained by determining ATCC13182 and ATCC10031 concentration in infant formular milk powder.Results: Recoveries of two bacterial strain determination method were 89.90% and 93.66% respectively and the lowest detection limit of method was 40 cfu/ml.Conclusion: Klebsiella can be separated easily and satisfactory recovery as well as low detection limit can be achieved by employing MACI as Klebsiella culture medium.
Indomethacin induces increase in gastric epithelial tight junction permeability via redistribution of occludin and activation of p38 MAPK in MKN-28 Cells.

Tight Junctions (TJ) create a paracellular barrier that is compromised when nonsteriodal anti-inflammatory drugs (NSAIDs) injure the gastric epithelium, leading to increased permeability. However, the mechanism of NSAID-induced gastric injury is unclear. Here, we examined the effect of indomethacin on barrier function and TJ in gastric MKN-28 cells. In concentration response studies, 500 µm indomethacin induced a significant decrease in transepithelial resistance (TER; 380 vs. 220 Ω·cm2 for control and indomethacin-treated cells respectively, p < 0.05), and increased dextran permeability by 0.2 vs 1.2 g/l (p < 0.05). These changes in barrier function were completely ameliorated by the p38 MAPK inhibitor (SB-203580) but not by JNK inhibitor (SP-600125) or MEK/ERK inhibitor (PD-98059). SiRNA knock down of p38 MAPK prevented the loss of barrier function caused by indomethacin in MKN-28 cells. Western analyses of TJ proteins revealed that expression of occludin was reduced by indomethacin, whereas there was n...
Understanding the Interactions of CO2 with Doped and Undoped SrTiO3.

SrTiO3 and doped SrTiO3 have a wide range of applications in different fields. For example, Rh-doped SrTiO3 has been shown to have photocatalytic activity for both hydrogen production and CO2 conversion. In this study, both undoped and Rh-doped SrTiO3 were synthesized by hydrothermal and polymerizable complex methods. Different characterizations techniques including X-ray photoelectron spectroscopy (XPS), XRD, Raman, and UV/Vis spectroscopy were utilized to establish correlations between the preparation methods and the electronic/structural properties of Rh-doped SrTiO3 . The presence of dopants and oxygen vacancies substantially influenced the CO2 interactions with the surface, as revealed by the in situ infrared spectroscopic study. The presence of distinctly different adsorption sites was correlated to oxygen vacancies and oxidation states of Ti and Rh.
The Structure of the Periplasmic Sensor Domain of the Histidine Kinase CusS Shows Unusual Metal Ion Coordination at the Dimeric Interface

In bacteria, two-component systems act as signaling systems to respond to environmental stimuli. Two-component systems generally consist of a sensor histidine kinase and a response regulator, which work together through histidyl-aspartyl phosphorelay to result in gene regulation. One of the two-component systems in Escherichia coli, CusS–CusR, is known to induce expression of cusCFBA genes at increased periplasmic Cu(I) and Ag(I) concentrations to help maintain metal ion homeostasis. CusS is a membrane-associated histidine kinase with a periplasmic sensor domain connected to the cytoplasmic ATP binding and catalytic domains through two transmembrane helices. The mechanism of how CusS senses increasing metal ion concentrations and activates CusR is not yet known. Here, we present the crystal structure of the Ag(I)-bound periplasmic sensor domain of CusS at a resolution of 2.15 A. The structure reveals that CusS forms a homodimer with four Ag(I) binding sites per dimeric complex. Two symmetric metal binding...
I Gave Rocuronium 3 Hours Ago, Do I Need to Reverse?

A 58-year-old woman with chronic low back pain secondary to nerve impingement presents for lumbar laminectomy and fusion. The patient has a history of coronary disease treated with a stent 3 years ago, as well as obesity and moderate chronic obstructive pulmonary disease (COPD) from smoking. Transcranial motor evoked potential monitoring will be performed during the procedure to assess motor function, so neuromuscular blocking drugs cannot be given during the case. One dose of rocuronium, 30 mg, is given at the surgeon’s request to aid the initial dissection, and no further muscle relaxation is administered for the rest of the operation. Three hours later, the patient is breathing spontaneously with good tidal volumes, seemingly ready for extubation. Your attending walks in and asks if the patient has been reversed.
A. Kolmogorov and M. Riesz Theorems for Octonion-valued Monogenic Functions

The classical M. Riesz theorem on the boundedness of the conjugation operator for harmonic functions and Kolmogorov’s weak-type inequality are proved in the framework of the octonion-valued monogenic functions.
Symbolic Computation for Rankin-Cohen Differential Algebras: A Case Study

Don Zagier defined a “Rankin-Cohen algebra”, motivated by the study of differential operators that send modular forms to modular forms. We devised an algorithm that computes the result of the differentiation given by the modular forms that correspond to higher-order Wronskians over Klein’s quartic curve, which are modular forms of arbitrarily high degree canonically attached to the curve; this tool is potentially useful for finding commutative rings of differential operators.
E-017 Prolonged bradycardia after carotid angioplasty and stenting

Introduction/purpose Bradycardia and hypotension are recognized complications after carotid artery angioplasty and stenting (CAS). Typically this is short-lived but may persist up to 1 week in cases with post stent angioplasty. We report the occurrence of prolonged bradycardia greater than 1 week after CAS without post stent angioplasty. Results A 58 year old man with past medical history of hypertension, diabetes mellitus, gout and smoking presented with left-sided hemiplegia and dysphagia. MRI demonstrated infarction within the right basal ganglia and right frontoparietal white matter. CT Angiography demonstrated, 99% stenosis of right ICA with tandem occlusion of the right middle cerebral artery. Due to tandem occlusion with poor collaterals and age younger than 70 years CAS was elected. Pretreatment was with aspirin and ticagrelor as he was clopidogrel resistant. Conscious sedation with fentanyl 25 µg and anticoagulation with bivalirudin was used. Angiography confirmed ICA stenosis greater than 70% by NASCET criteria. A balance middleweight 0.014-inch wire was used to cross the stenosis and the spider filter embolic protection device, 5 mm, was deployed. Submaximal angioplasty was performed using a 4 mm viatrac balloon to 8 atms. At this point the patient began to experience significant bradycardia and was given atropine. The balloon was removed. A protege 8–6 mm × 40 mm tapered stent was then deployed. Post-stenting angioplasty was not performed. The filter was retrieved. Final control angiogram internal carotid artery revealed less than 10% stenosis by NASCET criteria. Directly following the procedure, the patient’s BP was 84/53 with a HR of 63. A norepinephrine infusion was started and the patient was transferred to ICU. Hypotension persisted 20 hours. However, the patient also became profoundly bradycardic (heart rate equal 20–30 beats per minute). For the following 9 days, the patient continued to experience persistent bradycardia with intermittent asymptomatic decreases in BP (mean arterial pressure 40–60 mmHg) during periods of lowest heart rate. The bradycardia represented sinus bradycardia with sinus pauses without any heart block or junctional rhythms. Discussion Angioplasty induce sinus hypersensitivity syndrome is a complication of carotid angioplasty and stenting. Previous studies suggested that bradycardia lasts for a mean of 26 hours and almost never longer than 48 hours. To our knowledge prior to our report, the longest period of persistent bradycardia after carotid stenting was 7 days. Unlike our case, this occurred in a patient who had post stenting angioplasty. Also of note, the patient in our report did not experience any bradycardia during the 2 days prior to carotid angioplasty and stenting while on ticagrelor. Conclusion Rarely, prolonged bradycardia may occur and persist for greater than 1 week after carotid angioplasty and stenting even in cases without post stent angioplasty. Disclosures D. Archer: None. J. Ferdous: None. Y. Alderazi: None.
The Expanding Role of Ketamine in the Emergency Department

Patients frequently come to the emergency department for pain. For decades, ketamine has been used in the emergency department for procedural sedation but is now receiving attention as a potential alternative to opioids because of its unique analgesic effects. Additionally, ketamine's dissociative properties have made it a popular choice for sedating profoundly agitated patients. In this narrative review, these new roles for ketamine in the emergency department are discussed.
Implementation and performance evaluation of 100-kHz, soft-switched bidirectional PFC/inverter with silicon MOSFETs

In this paper, the performance of a bidirectional ac/dc converter which utilizes silicon MOSFETs and operates in continuous-conduction mode (CCM) with 100-kHz switching frequency is evaluated. The converter is implemented with an active snubber that virtually eliminates losses related to the reverse-recovery charge of the body diodes of Si MOSFET switches and also provides for their zero-voltage switching (ZVS). The circuit operation was verified with a 3.3 kW PFC/inverter experimental prototype designed for 230-Vrms nominal ac voltage and 400-V dc voltage. The measured circuit efficiency in both directions is greater than 97.9% at loads greater than 45%.
The case history and deferred pain.

Even when authors of case studies think they have concealed the identity of their patients, there is no guarantee that patients will not recognize themselves should they happen upon the narratives. And this recognition is very likely to cause them discomfort.
Quorum Systems in Replicated Databases: Science or Fiction?

A quorum system is a collection of subsets of servers, every two of which intersect. Quorum systems have been suggested as a tool for concurrency control in replicated databases almost twenty years ago. They promised to guarantee strict consistency and to provide high availability and fault-tolerance in the face of server crashes and network partitions. Despite these promises, current commercial replicated databases typically do not use quorum systems. Instead they use mechanisms which guarantee much weaker consistency, if any. Moreover, the interest in quorum systems seems to be waning even in the database research community. This paper attempts to explain why quorum systems have not fulfilled their old promises, and at the same time to argue why the current state of affairs may change. As technological advances bring new capabilities, and new applications bring new requirements, the time may have come to review the validity of some long standing criticisms of quorum systems. Another theme of this paper is to argue that if quorum systems are to play a role in database research, it is not likely to be for their claimed fault-tolerance capabilities. Rather, more attention should be given to a somewhat overlooked feature of quorum systems: they allow load balancing among servers while maintaining strict consistency. Thus quorum systems may offer a way to scale up the throughput of heavily loaded servers.
He Said, She Said: A Feminist Approach to Teaching the Twentieth-Century Novel in the Twenty-First Century

of their own work, especially in the United States" (230). Today, ten years later, the question of women's relationship to the literary canon still hangs in the air. This poses a particular problem for those of us who teach the twentieth-century French novel and are both guided by feminist pedagogy and constrained by departmental limitations. How do we, particularly those of us who teach undergraduates, give an overview of the genre without either diminishing the importance of certain male novelists or eliminating women novelists altogether? I suggest that a thematic approach, but one in which two different gender perspectives are made explicit, is the most useful. This strategy has many advantages. Although the works chosen and student capabilities will dictate the rhythm, six novels a semester is an appropriate number for my undergraduates; thus the breakdown into pairs of texts occurs quite naturally. On the one hand, this type of pairing privileges a great deal of creativity, 640
Applications of Quantum Stochastic Processes in Quantum Optics

These lecture notes provide an introduction to quantum filtering and its applications in quantum optics. We start with a brief introduction to quantum probability, focusing on the spectral theorem. Then we introduce the conditional expectation and quantum stochastic calculus. In the last part of the notes we discuss the filtering problem.
Mental Debility as the Superhero Trait of Today's Real Human in Alejandro González Iñárritu's Birdman

This article shows how director Alejandro Gonzalez Inarritu conflates notions of the mad-genius trope, mental illness, and the superhero in his film Birdman , exalting the mentally debilitated identity that is popular today under biocapitalism. It also explores how the film's concept of "real art" as dependent on the grotesque exhibition of mental debility is shaped by (and reinforces) our current biocapitalist notion of a real human experience.
Philosophy from the Bottom Up: Eknāth’s Vernacular Advaita

The sixteenth-century Marathi poet-saint Eknāth is better known for his devotional songs (abhaṅg) and allegorical drama-poems (bhārūḍ) than his “philosophical” writings. These writings include commentaries on and distillations of Sanskrit texts that feature a highly localized form of Advaita, or non-dualist Vedānta. Rather than consider them vernacular translations of the classical traditions of Advaita, I propose to read Eknāth’s philosophical works as embedded in a local context of non-dualist thought that filtered into the elite world of Sanskrit knowledge-systems. I provide examples from his Marathi commentary on the Sanskrit Hastāmalaka Stotra, a brief versified teaching on Advaita Vedānta. I also look at the para-textual material bracketing the content and some of the accompanying manuscript record, in order to understand the context for circulation and transmission of this material among Eknāth’s various readers over generations. My general attempt is to understand how ideas and practices belonging to local, vernacular networks filter into elite Sanskrit systems of knowledge—that is, not just into flexible genres like purāṇa but into disciplines, like Vedānta, that are generally viewed as impervious to the world around them. From my perspective, all knowledge is local, even that articulated in such cosmopolitan languages as Sanskrit. In Eknāth’s vernacular Advaita, we find evidence for a much wider scope for the movement of ideas, one that moves not from top-down but bottom-up.
Prediction of Thermal Residual Stress and Microstructure in Direct Laser Metal Deposition via a Coupled Finite Element and Multiphase Field Framework

Direct laser metal deposition (DLMD) is a modern powder-fed additive manufacturing process, which builds up complex objects layer by layer, providing a potential capacity to produce key structural components specifically for the aerospace industry. The printing process is of a multidisciplinary nature, and has gained increasing attention in the areas of engineering mechanics, material science, control engineering and many other related fields. The quality control of the printed part depends on a large number of process parameters. The aim of this work, therefore, is to develop a coupled finite element and multiphase field framework, that provides an effective way to understand the quantitative relationship between the process parameters, temperature history, thermally-induced residual stresses and microstructures in the DLMD process. More specifically, the established multiscale framework is able to sequentially couple the heat transfer, metal melting/solidification, and stress analysis to simulate the macroscopic temperature distribution, thermal residual stresses and dendrite growth and solute segregation in a thin wall structure made of a binary nickel-copper alloy. The latest simulation technologies are used to model the process of progressive material deposition as well as the movement of the laser beam. It has been found that the high intensity laser introduced in DLMD can produce a complex thermal history and a significant level of thermal residual stresses and distortion. Microstructure predictions demonstrate the location-dependent morphology evolution, e.g., the dendrite spacing and the degree of solute segregation, attributed to the spatially variant temperature history.
DIABETIC KETOACIDOSIS AND ST-ELEVATION MYOCARDIAL INFARCTION: THE CHICKEN OR THE EGG

Diabetic ketoacidosis (DKA) and ST elevation myocardial infarction (STEMI) may precipitate each other. Furthermore, the sequence of acute management is confounded by the rare pseudoinfarct phenomenon of DKA. A 67 year old diabetic male presented with typical chest pain for 24 hours that ceased with
Development and Validation of a Comprehensive Well-Being Scale for People in the University Environment (Pitt Wellness Scale) Using a Crowdsourcing Approach: Cross-Sectional Study.

Background: Well-being has multiple domains, and these domains are unique to the population being examined. Therefore, to precisely assess the well-being of a population, a scale specifically designed for that population is needed. Objective: The goal of this study was to design and validate a comprehensive well-being scale for people in a university environment, including students, faculty, and staff. Methods: A crowdsourcing approach was used to determine relevant domains for the comprehensive well-being scale in this population and identify specific questions to include in each domain. A web-based questionnaire (Q1) was used to collect opinions from a group of university students, faculty, and staff about the domains and subdomains of the scale. A draft of a new well-being scale (Q2) was created in response to the information collected via Q1, and a second group of study participants was invited to evaluate the relevance and clarity of each statement. A newly created well-being scale (Q3) was then used by a third group of university students, faculty, and staff. A psychometric analysis was performed on the data collected via Q3 to determine the validity and reliability of the well-being scale. Results: In the first step, a group of 518 university community members (students, faculty, and staff) indicated the domains and subdomains that they desired to have in a comprehensive well-being scale. In the second step, a second group of 167 students, faculty, and staff evaluated the relevance and clarity of the proposed statements in each domain. In the third step, a third group of 546 students, faculty, and staff provided their responses to the new well-being scale (Pitt Wellness Scale). The psychometric analysis indicated that the reliability of the well-being scale was high. Conclusions: Using a crowdsourcing approach, we successfully created a comprehensive and highly reliable well-being scale for people in the university environment. Our new Pitt Wellness Scale may be used to measure the well-being of people in the university environment.
College student aerobic and muscle-strengthening activity: the intersection of gender and race/ethnicity among United States students

To adopt an intersectional approach to examine differences in aerobic and muscle-strengthening participation based on the intersection of gender and race/ethnicity among college students. Methods: ...
Tilting Back Toward Development: Response to Steven Cooper’s “Donald Winnicott and Stephen Mitchell’s Developmental Tilt Hypothesis Reconsidered”

In this commentary on Steven Cooper’s paper (this issue), the author agrees with his exposition and discussion of the issues attendant on Stephen Mitchell’s theory of the developmental tilt, in par...
Bilateral Squatting Mechanics Are Associated With Landing Mechanics in Anterior Cruciate Ligament Reconstruction Patients.

Background:Proper lower extremity biomechanics during bilateral landing is important for reducing injury risk in athletes returning to sports after anterior cruciate ligament reconstruction (ACLR)....
ColdFront: Resource Allocation Management System

ColdFront is an open source resource allocation management system, designed to provide a central portal for administration, reporting, and measuring scientific impact of cyberinfrastructure resources. It enables managing access to a diverse set of resource types across large groups of users and provides a rich set of extensible meta data for comprehensive reporting and integration with legacy systems. In this paper we introduce ColdFront, describe three main stakeholders, present the features and integrations currently implemented, and make the case for why ColdFront is vital to enabling research and reducing time-to-science. ColdFront is freely available at https://github.com/ubccr/coldfront.
Exploration and Practice of Dance Teaching Mode under the Internet Background

In early 2020, the new crown pneumonia epidemic swept in, in order to block the spread of the epidemic to the campus, the Ministry of Education issued the "spring semester delayed school opening" request, "stop classes do not stop" the voice immediately rang. At one time, how to combine modern information technology with the teaching content of various subjects to maximize the efficiency of online teaching has become the primary problem for every teacher to think about, and in this environment, the dance educators who are mainly based on the traditional teaching form of "oral teaching" also ushered in a great test. By analyzing the advantages and disadvantages of traditional dance teaching methods and based on the author's online teaching practice activities for one semester, this paper makes a comprehensive analysis of the application value and significance of modern information technology in Chinese dance teaching, in order to further enrich the Chinese dance teaching mode, optimize the dance teaching resources, make the dance teaching methods and contents more in line with the requirements of China's modern technology, and provide theoretical basis and practical operation guidance for the future modern dance teaching mode.
Particle emissions from mobile sources: Discussion of ultrafine particle emissions and definition

Abstract There is no universally agreed upon definition for ultrafine particles (UFP). Commonly used definitions for UFP are either particle number below 100 nm or total particle number, but without an agreed upon lower cut point. For example, a lower cut point of 3 nm compared to 10 nm could result in a substantially higher count. Another definition for UFP is total particle mass but without a commonly agreed upon aerodynamic diameter upper cut point, e.g., below 100 nm, 200 nm, 300 nm, etc. Yet another definition is lung deposited surface area weighted by lung deposition fraction, found mainly in the particle mobility diameter range from 20 to 400 nm. It is clear from these definitions that there are inconsistencies in the way UFP is used and defined in the literature. Sometimes these metrics are well correlated, sometimes not. In this paper we suggest three exposure metrics: UFP-N, UFP-M, and UFP-S, that we believe will add clarity. These metrics represent total number, mass, and surface area below 500 nm, respectively. For surface area and mass, the 500 nm cut point can be either aerodynamic or mobility diameter depending upon measurement methodology. For all metrics, this cut point captures nearly all of the primary particle emissions from mobile sources. Furthermore, UFP-N would include a lower cut point of 3–6 nm and would not require an upper size cut point because there is very little particle number above 500 nm or even above 100 nm. Thus, our definition of UFP-N is consistent with the current definition of ultrafine number except for, importantly, the specification of a lower cut point. These exposure metrics can help facilitate consistency in the characterization of both short- and long-term UFP ambient exposures and associated health effects in epidemiological studies.
Dietary functional ingredients and quality of irradiated turkey breast meat

Four hundreds and eighty male turkeys (12-week-old, raised on a corn-soybean basal diet) were randomly allotted to 32 pens (4 pens/treatment, 15 birds/pen) and were fed 8 experimental diets supplemented with none (Control, Con), 200 IU/kg vitamin E (VE), 0.3 ppm Se (SE), 2.5 % CLA (CLA), 200 IU/kg vitamin E+0.3 ppm Se ( VE+SE), 200 IU/kg vitamin E+2.5%CLA (VE+CLA), 2.5%CLA+0.3ppm Se (SE+CLA), or 200 IU/kg vitamin E+0.3ppm Se+2.5%CLA (VE+CLA+SE). At 15 weeks of age, all birds were slaughtered and breast muscle of 8 birds from each pen were separated and ground. Raw breast meat patties were prepared and irradiated with a Linear Accelerator with a dose of 0 or 1.5 kGy. Lipid oxidation, color, and aromatic volatiles of the raw meat patties were measured after 0, 7, and 12 days of storage at 4 °C. Vitamin E, Se, and fatty acids composition were also determined. Dietary supplemental level of vitamin E and CLA increased deposits of each in turkey breast. Dietary CLA decreased monoand non-CLA polyunsaturated fatty acids content in meat. Irradiation increased (p < 0.05) lipid oxidation and Hunter color a* value. Dietary Vitamin E, Se, CLA alone and their combinations decreased (p < 0.05) lipid oxidation in meat caused by both irradiation and storage. Production of off-odor in turkey breast meat caused by storage and ionizing irradiation were reduced by dietary vitamin E, selenium , or CLA, especially when vitamin E was combined with selenium, or CLA, or both selenium and CLA. Lipid oxidation, interior color, and off-odor volatiles of cooked breast patties were evaluated under vacuum and aerobic packaging after 0 and 7 days storage. Dietary treatment VE+Se, VE+CLA, Se+CLA, and VE+Se+CLA reduced lipid oxidation of cooked irradiated (1.5 kGy) turkey breast meat samples by 24%, 29%, 26%, and 40%, respectively compared
Actions of mammalian pituitary gonadotropins (FSH and LH) in reptiles. 1. Male snakes.

Ovine FSH and LH were tested in hypophysectomized male snakes, Thamnophis sauritus and T. sirtalis. FSH was considerably more potent than LH and appeared capable of stimulating testis growth, spermatogenesis, and interstitial cell activity (androgenesis). The effects of relatively large amounts of LH were comparable to a low dose of FSH in promoting slight spermatogenic activity; LH did not differentially affect steroiodogenesis. Testosterone did not affect spermatogenesis in T. sirtalis. These results confirm previous findings with purified mammalian hormones in lizards, and suggest that all aspects of testicular function in squamate reptiles may be accounted for by a single FSH-like gonadotropin.
Theories of Heavy-Ion Interaction Potentials for Giant Dinuclear Systems

In this lecture, I would like to discuss the nuclear aspects of the physics of strong electromagnetic fields. In particular, I shall address the following questions: a) Is it possible to form giant nuclear molecules (e.g. 238U+238U) with a lifetime of about lO-19 s in a heavy-ion reaction at bombarding energies near the Coulomb barrier? b) What are the implications of dynamical nuclear alignment (due to Coulomb excitation) for nuclear “sticking”? The formation of very heavy intermediate nuclear molecules plays a vital role not only for spontaneous positron creation but also for the possible production of light neutral elementary particles (axion) or composite particle (poly-positronium).
Murine colitis treated with multitargeted tyrosine kinase inhibitors.

Abstract Background Angiogenesis, a known pathogenic component of neoplastic and nonneoplastic diseases, serves as a therapeutic target. Vascular endothelial growth factor (VEGF) and angiogenesis are clinically elevated in inflammatory bowel disease. By targeting vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with receptor tyrosine kinase inhibitors in a murine model of colitis, we hypothesize that angiogenesis will be suppressed and disease severity improved. Methods and methods Sorafenib, sunitinib, and axitinib were administered by oral gavage in a murine model of dextran sodium sulfate (DSS) colitis. Inflammation score, microvessel density (MVD), and gene expression of VEGF, VEGFR, platelet-derived growth factor, PDGFR, Ang-2, and epidermal growth factor receptor was assessed. Results Inflammation and MVD were elevated in groups receiving DSS, but were similar between DSS-only and treatment cohorts. Unexpected weight loss was present in the gavaged groups versus DSS only. In treated groups, VEGFR was significantly decreased (P = 0.002) and VEGF gene expression trended down (P = 0.213) versus DSS only. Neither the platelet-derived growth factor/PDGFR pathway nor the alternative pathways, Ang-2 and epidermal growth factor receptor, were significantly changed from DSS control in treatment cohorts. Conclusions This study confirms the association between inflammation and MVD. Antiangiogenic receptor tyrosine kinase inhibitors suppressed the VEGF/VEGFR pathway but the expected decrease in colonic MVD did not follow, suggesting possible involvement of other angiogenic pathway(s). In the DSS model of colitis, vehicle selection and mouse strain can impact disease response.