cssi/SciSciGPT-SciSciNet huggingface dataset:
Topological density-wave states in a particle-hole symmetric Weyl metal

We study the instabilities of a particle-hole symmetric Weyl metal with both electron and hole Fermi surfaces (FSs) around the Weyl points. For a repulsive interaction we find that the leading instability is towards a longitudinal spin-density-wave $({\mathrm{SDW}}_{z})$ order. Besides, there exist three degenerate subleading instabilities: a charge-density-wave (CDW) instability, and two transverse spin-density-wave $({\mathrm{SDW}}_{x,y})$ instabilities. For an attractive interaction the leading instabilities are towards two pair-density-wave (PDW) orders which pair the two FSs separately. Both the PDW and ${\mathrm{SDW}}_{z}$ order parameters fully gap out the FSs, while the CDW and ${\mathrm{SDW}}_{x,y}$ ones leave line nodes on both FSs. For the ${\mathrm{SDW}}_{z}$ and the PDW states, the surface Fermi arc in the metallic state evolves to a chiral Fermi line which passes the projection of the Weyl points and traverses the full momentum space. For the CDW state, the line node projects to a ``drumhead'' band localized on the surface, which can lead to a topological charge polarization. We verify the surface states by computing the angular-resolved photoemission spectroscopy data.
Primarily Analysis on Effects of Main Meteorological Factors on Growth and Development of Rice

From the meteorological angle,the precipitation,temperature,light,carbon dioxide concentration,relative humidity,wind speed and other meteorological condition on rice growth and development were explained.It provided a scientific basis for the rice in the course of a full course of growth and development of monitoring and forecasting.
Relationship of Prepharmacy Repeat Course History to Students' Early Academic Difficulty in a Pharmacy Curriculum.

Objective. To examine the relationship between students’ prepharmacy repeat course history and their academic difficulties early in a professional pharmacy program in conjunction with other prerequisite success variables known to predict academic difficulty.Methods. For students admitted to a pharmacy program in 2010 and 2011 (n=160), admission variables [eg, prepharmacy coursework, grade point average (GPA)] and pharmacy program academic difficulty data (ie, academic difficulty defined as a pharmacy GPA in the bottom quartile of the class after 3 semesters of pharmacy course work) were extracted. Regression analysis was employed to examine the relationship between admission variables and academic difficulty.Results. Twenty-six percent of the students (n=42) repeated a course, and 50% of these students (n=21) repeated more than one course. All of the admissions variables studied were found to individually increase the odds of a student having academic difficulty early in the pharmacy program. Specifically...
Sex and Race/Ethnicity Differences in Implantable Cardioverter-Defibrillator Counseling and Use Among Patients Hospitalized With Heart Failure: Findings from the Get With The Guidelines-Heart Failure Program

Background:Previous studies have found that women and black patients eligible for a primary prevention implantable cardioverter-defibrillator (ICD) are less likely than men or white patients to rec...
5.01 – Corrosion and Compatibility

This chapter is meant to provide the reader with the fundamental electrochemistry necessary to critically evaluate the data and discussions in the chapters on corrosion that follow. As such it has two main sections, theory and analytical methods. In the section on theory, a review of half cell reactions, cell potentials and the Nernst equation, and reference electrodes in nuclear systems are discussed. In addition, a review of the thermodynamics from room temperature to the PWR and kinetics of dissolution and passive film formation is also presented. In the section on analytical methods, we review the principles of potentiodynamic polarization, electrochemical impedance spectroscopy, and we introduce a more seldom used technique, Mott-Schottky analysis.
How to Effectively Integrate Professionally Oriented Faculty to Achieve the Department's Mission

ABSTRACT The purpose of this commentary is to describe the successful assimilation of Professionally Oriented Faculty into the department of accounting through the use of the Pathways Commission Professionally Oriented Faculty Integration Principles. Further, building upon the Integration Principles, we provide recommendations for attracting and retaining Professionally Oriented Faculty. We accomplish this by describing the varied journeys of six different Professionally Oriented Faculty as compared with the POF Integration Principles. We also summarize the Professionally Oriented Faculty Integration Principles and encourage adoption by member institutions of these principles with an affirmative statement.
Morgan Pitelka, Spectacular Accumulation: Material Culture, Tokugawa Ieyasu, and Samurai Sociability

Lavishly illustrated in color, with a compelling analysis of late sixteenth- and early seventeenth-century warlord culture, this book is certain to attract readers of political, cultural, military,...
Frogging It: A poetic Analysis of Relationship Dissolution

Often, themes in work and life intertwine; the author recognized that a cadre of poems she had written during the past several years were about relationship dissolution. The poems concerned romantic and friendship dissolution and the aspects of identity creation and loss this entails. The author presents the poems and makes an explicit connection to interpersonal relationship dissolution literature through the technique of poetic analysis. This analysis serves as an exemplar for how poetry as performative writing offers a valuable addition to interpersonal communication research through the poeticizing of relational dissolution as an everyday relational challenge.
How Wealth Inequality Shapes Our Future

Liz, Mary, and Howard are three teenagers in the 1980s. Although unrelated, their families have much in common: stable two- parent households, at least one parent completed high school (though none of them went to college), and all three are white. They differ in one important aspect: their parents command quite different levels of wealth (here measured as net worth, that is, the total sum of financial and real assets minus debt). Liz's parents own less than $700 (inflation adjusted to 2013 dollars), meaning that Liz grows up at the bottom of the wealth distribution. Still, she is far from living in poverty thanks to her parents' annual income of about $50,000. Mary's parents have a somewhat higher income, about $70,000, but also markedly more wealth than Liz's parents: their net worth of roughly $60,000 puts them at about the national median of the time. Also unlike Liz's parents, they are homeowners. Howard is lucky enough to grow up in affluence. Not in terms of income, given that his parents have a household income of only about $40,000, but they have considerable wealth. With a net worth of nearly a quarter million dollars, Howard's parents are in the top 20 percent of wealth holders. They, too, own their home.
The Effects of Satiation on Strike Mode and Prey Capture Kinematics in the Largemouth bass, Micropterus salmoides

The feeding mechanism and kinematics of prey capture have been studied in many fishes. However, the effects of satiation on the strike mode and prey capture kinematics have never been directly measured. We analyze 12 kinematic variables to determine the effects of satiation on prey capture in five largemouth bass, Micropterus salmoides, by using high speed videography. We also present the first experimental test for modulatory capabilities in response to satiation, by using the ram-suction index. Significant changes in the kinematic variables of maximum lower jaw depression, maximum gape distance, maximum hyoid depression, time to maximum hyoid depression, and time from maximum hyoid depression to recovery were seen with the effects of satiation. Change in the kinematic variables imply a decrease in jaw opening velocity and the magnitude of suction velocity created during repetitive strikes by M. salmoides with increasing satiation. The bass primarily uses a ram strike mode, with some suction bites occasionally. Ram-suction index analyses suggests that M. salmoides does not modulate strike mode in response to satiation. However, the bass modulate prey capture kinematics without altering strike mode with the effects of satiation. Prey capture success decreases in each bass, as the probability of a successful prey capture event becomes lower, with increasing satiation. These findings demonstrate that satiation can have major effects on prey capture kinematics and future studies of feeding kinematics should account for satiation in their analyses.
Religious Observances, Festivals, and Celebrations

This chapter provides basic information about various religious observances, festivals, and celebrations in a number of major religions. Similarities between the observances and their manner of celebration are noted. An awareness of these observances is important in the context of social workers’ efforts to support diversity and inclusion and to assist individuals and families to address conflicts and anxieties that may be associated with these observances.
Radiofrequency ablation (RFA) vs. argon plasma coagulation (APC) for the management of gastric antral vascular ectasia (GAVE) in patients with and without cirrhosis: results from a retrospective analysis of a large cohort of patients treated at a single center.

Introduction and study aims Gastric antral vascular ectasia (GAVE) is a mucosal abnormality associated with multiple conditions, most notably cirrhosis and systemic sclerosis, that causes indolent gastrointestinal bleeding. It is primarily managed with endoscopic therapy. Traditionally, GAVE is endoscopically ablated using argon plasma coagulation (APC) but radiofrequency ablation (RFA) is emerging as an alternative modality. No prior comparison of the 2 modalities has been published. We retrospectively compared the effects of GAVE ablation with either RFA, APC or both in the largest cohort of patients thus far presented. We also attempt to discern what effect concomitant cirrhosis has on response to treatment. Patients and methods After receiving IRB approval, we reviewed our electronic health records to identify all patients who underwent endoscopic evaluation for GAVE between January, 2011 and October, 2016. We compared important variables between APC and RFA, as well as between cirrhosis and non-cirrhosis, using the Chi-square test and the Wilcoxon two-sample test as appropriate. Results During our study period, 81 patients were endoscopically evaluated for GAVE. 24 patients were treated with APC alone, 28 with RFA alone and 25 patients received both treatment modalities. APC-treated patients underwent a mean of 2.4 treatment sessions with a mean of 205 days between treatments. RFA-treated patients underwent a mean of 2.3 treatment sessions with a mean of 100 days between treatments. Hemoglobin values remained stable or increased in all patients during our study period and there were no significant differences in Hgb trend between those treated with APC and those with RFA. Conclusions RFA and APC were both effective in treating bleeding from GAVE. Though we found subtle differences, patients underwent a similar number of treatment sessions and had similar procedure times and a similar time between sessions no matter the treatment modality used.
Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders

Past 25y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients' conditions for instituting treatment plan(s) and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients' susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.
Rebleeding vs Thromboembolism After Hospitalization for Gastrointestinal Bleeding in Patients on Direct Oral Anticoagulants.

Background & Aims Little is known about outcomes of patients hospitalized for gastrointestinal bleeding (GIB) while they are taking direct oral anticoagulants (DOAC). We aimed to determine the frequency at which patients resume DOAC therapy following hospitalization for GIB in a real-world setting, and the risks and benefits. Methods We conducted a retrospective analysis of medical claims data from the Truven Health Marketscan Commercial Claims and Encounters Database, from January 1, 2010, through December 31, 2014. We collected data on 1338 adults treated with DOACs and hospitalized for GIB (dabigatran, n = 679; rivaroxaban, n = 608, apixaban, n = 51). Patients who developed GIB within 1 year of DOAC initiation, and had a DOAC claim filled within 1 month of GIB, were included in the analysis. Postdischarge readmissions due to thromboembolism and recurrent GIB within 90 days were reviewed. We used proportional hazards to identify factors associated with thromboembolism and recurrent GIB. Results The median age of patients who did not resume DOAC therapy was older (79 vs 78 y for patients who did resume DOAC therapy; P = .0005). Higher proportions of patients who did not resume DOAC had heart failure (25% vs 20% who did resume DOAC therapy; P = .01), received blood (36% vs 24%; P Conclusions In a retrospective analysis of medical claims data from adults treated with DOACs and hospitalized for GIB, we found that older patients who require blood and intensive care were less likely to restart treatment with DOACs after GIB. Resuming DOAC therapy was not associated with thromboembolism within 90 days or recurrence of GIB; a history of venous thromboembolism and thienopyridine use were associated with a risk of subsequent thromboembolism and GIB respectively.
Model filled rubber Part V Mechanical properties of rubbery composites

Monodisperse size crosslinked polymeric particles of specific chemical compositions, synthesized by emulsifier-free emulsion polymerization, were used as model fillers to study the effect of filler chemical composition on stress-strain behavior of rubbery composites. The modulus, E or G of filled composites increased while the stress and the strain at break decreased with increasing filler-matrix interactions. Physical crosslinking, either due to particle clustering or a network of filler particles with an adsorbed polymer layer supplemented chemical crosslinking. As a result, the overall crosslink density(chemical and physical) was effectively enhanced. The strength of the physical networks, and hence the stiffness of the composites increases with increasing particle-matrix interactions. However, excessively strong matrix-filler interaction would cause a loss of polymer flexibility at the particle-matrix interface, resulting in a decreased stress and elongation at break of the particle filled composites in the order PS > PMMA > PSVP.
Blogosphere Authority Index 2.0: Change and Continuity in the American Political Blogosphere, 2007–2010

Political blogs have emerged as a vibrant component of the information ecology of American politics. Previous scholars have described bloggers as ‘agenda seekers’ or as the digital equivalent to Op-ed columnists (Hindman 2008; Davis 2009). Researchers have investigated the motivations of bloggers and their attentive readers, the impact of blogs on elections, the demographics of reader bases and the mass participatory and agenda-setting impacts of the medium (McKenna and Pole 2004; Wallsten 2007, 2008; Pole 2009; Gil de Zuniga et al. 2009; Gil de Zuniga et al. 2010; Lawrence et al. 2010). A few scholars have also explored structural differences between the left and right blogospheres (Karpf 2008b; Benkler and Shaw 2010). Once a passing curiosity with a funny name, blogs today have become a well-established piece of the political landscape. They have been replaced by Twitter as the funny-sounding social media object of fascination. Blogs have been incorporated into existing media and political institutions, even being termed ‘passe’ in some circles.
An Improvement in the Lack-of-Fit Optimality of the (Absolutely) Continuous Uniform Design in Respect of Exact Designs

Designs which have equal numbers of observations taken over a finite set of uniformly spaced points are most popular in practice. For optimum properties of such exact uniform designs, however, reference is often made to the lack of fit (LOF)-optimality of the corresponding absolutely continuous uniform design which is considered as the asymptotic design for the exact uniform designs. It is shown that LOF-optimality in its original form has no relation to exact uniform designs. Subsequently we give conditions under which an interpretation for exact uniform designs is possible.
Hominids, Energy, Environment, and Behavior in the Late Pleistocene

From the first recognition of Western European Neandertals as physically distinct from present-day Homo sapiens, the significance of these differences for the relationships between the two kinds of hominids has been a topic of continuing debate among students of human evolution. The nature and substance of these arguments have been described in detail elsewhere (e.g., Klein 1989; Trinkaus and Howells 1979) and will not be treated extensively here. Some of the basic questions around which the discussions have centered concern possible differences in intellectual and physical abilities, and the genetic relationships of the two forms. Despite the length of time these questions have been considered, there is still relatively little general agreement on the interpretation of this Late Pleistocene fossil and cultural evidence. The discussion below is an attempt to integrate some of the cultural, biological, and paleoenvironmental evidence in an interpretive framework that emphasizes the kinds of potentially meaningful relationships among these variables that may take us closer to answers to the basic questions of the relationships between Neandertals and early examples of hominids like ourselves.
Combining markov models and association analysis for disease prediction

An approach for disease prediction that combines clustering, Markov models and association analysis techniques is proposed. Patient medical records are clustered and a Markov model for each cluster is generated to perform prediction of illnesses a patient could likely be affected in the future. However, when the probability of the most likely state in the Markov models is not sufficiently high, it resorts to sequential association analysis, by considering the items induced by high confidence rules generated by recurring sequential disease patterns. Experimental results show that the combination of different models enhances predictive accuracy and is a feasible way to diagnose diseases.
A phase II study of ramucirumab for advanced, pre-treated biliary cancers.

4081Background: Biliary cancers (BC) have no clear second-line therapy in advanced disease after progression on standard of care gemcitabine and cisplatin. Angiogenesis has been shown to be a poten...
Mechanical, thermal, conductivity, and electrochemical behavior of poly(vinylidene fluoride)/poly(3,4-ethylenedioxythiophene)/polyaniline-grafted-nanodiamond nanocomposite:

This study reports on novel poly(vinylidene fluoride)/poly(3,4-ethylenedioxythiophene) (PVDF/PEDT) blend and nanocomposite. Polyaniline functional nanodiamond (PANI-ND) was prepared through in situ...
SO2/O2-Separation Process in Thermochemical Cycles for Water Decomposition

The process step of SO2-O2 — separation, investigated in this study, is part of the Euratom Mark 11-V6 thermochemical cycle for water decomposition. This process step is characterized by the combination of SO2 — condensation and scrubbing of the oxygen-rich gas phase in order to separate a gas mixture of 150000 m3 N /h, containing a SO2 — fraction of 2/3. According to the phase equilibrium data the condensation should rather be achieved by cooling than by compression. Furthermore, a higher pressure would induce the formation of byproducts and increase the detrimental O2 — solubility in liquid SO2. Investigations in the interesting range show that the O2 — solubility in SO2 also increases slightly with higher temperatures. As to the temperature and pressure range of the SO2-H2O-ratio in the liquid phase there is no danger of formation of SO2-H2O — hydrates nor of getting into the miscibility gap. The chosen operation conditions allow the application of standardized refrigerators. If the produced oxygen is not vented into the atmosphere, but made use of for other purposes, the returns will exceed the operation costs of the process step, provided that these huge amounts of oxygen can be made use of.
Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

The dynamics of CNS function rely upon omnidirectional communication among CNS cell types. Extracellular vesicles (EVs) have emerged as key mediators of this communication and are actively involved in response to CNS injury, mediating inflammatory response and inflammation-related neuroprotection as they display dual beneficial and detrimental roles. Neuroimmune interactions include communication between neurons and microglia, the resident macrophages within the CNS, and these interactions are a critical mediator of healthy brain functions, mounting an inflammatory response, and disease pathogenesis. This review aims to organize recent research highlighting the role of EVs in health and neurodegenerative disorders, with a specific focus on neuroimmune interactions between neurons and glia in Alzheimer's disease.
A Schutzian Theory of Nursing

Writings of several phenomenological nurses are used to show how nursing practice can have scientific foundations in a social psychology conceived of in Schutzian terms.
Racial Animus Is Decreasing Support for the Voting Rights of Citizens with Felony Convictions

Felon disenfranchisement laws disproportionately affect poor and minority populations. Using data from an original module in the 2013 Congressional Cooperative Election Study, this study demonstrates that negative racial attitudes are decreasing support for the voting rights of citizens with felony convictions. The results find that Non-Hispanic Whites with greater racial animus are less supportive of allowing citizens with felony convictions to vote, despite the ostensibly race-neutral nature of the policy. The effects of racial attitudes on public opinion are strongest when the citizen was convicted of stereotypical Black crimes, compared to stereotypical White crimes. Racial animus also make individuals less likely to be persuaded by arguments in favor of voting rights, and more susceptible to arguments against voting rights – particularly when the arguments are more directly linked to race. The magnitude of the impact of racial attitudes on support for voting rights is notable inasmuch as it is often the most important antecedent variable in the model.
Development of a novel in ovo challenge model for virulent Escherichia coli strains.

ABSTRACT During the hatching process, chicks are exposed to opportunistic and/or pathogenic organisms, such as virulent or avirulent Escherichia coli. Virulent E. coli strains have not been feasible for induction of neonatal colibacillosis via in ovo challenge due to high embryonic mortality. In this manuscript, we describe the addition and co-administration of the bacteriostatic antibiotic tetracycline to a virulent E. coli challenge culture, improving hatchability and livability of seeder chicks while allowing robust horizontal transmission in the hatching cabinet to contact chicks. Experiment 1 consisted of 3 trials. Experiment 1, trial 1 was conducted to determine an effective ratio of E. coli challenge and tetracycline dose to be utilized in the seeder model. Trials 2 and 3 were conducted to evaluate the transmission of E. coli from seeder to contact chicks. Experiment 2 consisted of 3 independent 7-D trials where body weight gain (BWG), mortality, and selected enteric bacterial recovery were evaluated. In trials 1 to 3, significantly (P
Understanding and Harnessing Variability in Regenerative Engineering

Tissue engineering and regenerative medicine aim to eliminate the shortage of donor organs and restore tissue or organ function through products that promote cellular regeneration. However, these fields have not been able to deliver on the transformation of healthcare with regenerative products. Convergence research, the deep integration of disparate disciplines with the goal of solving a societal grant challenge, may potentially revolutionize our approach to regenerative medicine with the creation of new scientific language, frameworks, and workforce. Regenerative engineering is a convergence field whereby materials science, physical sciences, biological sciences, and translational medicine converge with the goal of creating scalable and reliable tools that regenerate or reconstruct functional tissues and organs. Key challenges associated with regenerative engineering product variability and potential strategies to overcome those problems such as the development of smart regenerative systems are discussed. These topics were covered in the “Exploring Sources of Variability Related to Clinical Translation of Regenerative Engineering Products” workshop that took place on October 18, 2018. The Holy Grail for researchers in the fields of regenerative medicine and tissue engineering has been to eliminate the shortage of donor organs or restore tissue or organ function through commercially available products. However, the expected transformation of healthcare with regenerative products has not occurred. Convergence research, the deep integration of very different disciplines with the goal of solving a society’s major problems, may potentially revolutionize our approach to regenerative medicine with the creation of new scientific language, frameworks, and workforce. Regenerative engineering is a convergence field whereby materials science, physical sciences, biological sciences, and translational medicine converge with the goal of creating scalable and reliable tools that regenerate or reconstruct functional tissues and organs. Key challenges associated with regenerative engineering product variability and potential strategies to overcome those problems such as the development of smart regenerative systems are discussed. These topics were covered in the “Exploring Sources of Variability Related to Clinical Translation of Regenerative Engineering Products” workshop that took place on October 18, 2018.
Protein N-Myristoylation

Protein N-myristoylation refers to the covalent attachment of myristic acid, a 14-carbon saturated fatty acid (C14:0), to the N-terminal glycine of proteins. Linkage occurs via an amide bond and takes place as proteins are being synthesized. N-myristoylproteins have varied intracellular destinations, and are involved in myriad cellular functions ranging from signal transduction to protein and vesicular trafficking. N-myristoylproteins are encountered in members of all kingdoms of the eukaryotic domain (Protist, Fungi, Plant, and Animal), but are not produced by members of Bacteria or Archaea. MyristoylCoA: protein N-myristoyltransferase (Nmt), E.C. 2.3.1.97, a member of the GCN5 acetyltransferase (GNAT) superfamily, is responsible for catalyzing the transfer of myristate from myristoylCoA to proteins. While the acylCoA substrate specificity of Nmt has been highly conserved during evolution, its peptide substrate specificities have diverged among eukaryotes. Protein N-myristoylation has relevance to a number of diseases. Genetic and pharmacologic studies have shown that Nmt activity is essential for the survival of a number of fungi that cause systemic infections in immunocompromised humans. These organisms include Candida albicans and Cryptococcus neoformans. Protein N-myristoylation is also critical to the life cycle of viruses, such as human immunodeficiency virus-1. Nmt levels are elevated in human gastrointestinal tract malignancies. Other pathogens, including Plasmodium falciparum, the parasite that causes malaria, have Nmts. Therefore, understanding the contributions of myristate to protein function, elucidating the structural basis for the divergent protein substrate specificities of orthologous Nmts, characterizing the myristoyl transfer reaction, and identifying biologically active, species-selective Nmt inhibitors may provide new therapeutic strategies and agents.
Bedside Mental Status Evaluation: Overview, Coconuts, Cobe-50

Current clinical neuroscientists and their domains of cognitive testing include neurologists, psychiatrists, neuropsychologists, and speech and language clinicians, along with neuro-radiologists providing critical and complementary information of lesion location. All are important to capture the extent and nature of the deficits. For example, any degree of significant aphasia will curtail the number and type of testing that is possible. The abulic spectrum of disorders may severely limit testing and the mild and often covert forms of inattention due minimal hepatic encephalopathy (MHE) with elevated ammonia level precludes in depth neuropsychological assessment. It is not unusual for people with MHE to present because of multiple motor vehicle accidents on account of their inattention. As with most frontal lobe syndromes, the spouse, family, or other informant is most important.
Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo.

Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease, modulating the location and severity of inflammation and fibrosis. TL1A expression is increased in inflamed mucosa and associated with fibrostenosing Crohn's disease. Tl1a-overexpression in mice causes spontaneous ileitis, and exacerbates induced proximal colitis and fibrosis. Intestinal fibroblasts express Death-receptor 3 (DR3; the only know receptor for TL1A) and stimulation with TL1A induces activation in vitro. However, the contribution of direct TL1A-DR3 activation on fibroblasts to fibrosis in vivo remains unknown. TL1A overexpressing naive T cells were transferred into Rag-/- , Rag-/- mice lacking DR3 in all cell types (Rag-/-Dr3-/-), or Rag-/- mice lacking DR3 only on fibroblasts (Rag-/-Dr3∆Col1a2) to induce colitis and fibrosis, assessed by clinical disease activity index, intestinal inflammation, and collagen deposition. Rag-/- mice developed overt colitis with intestinal fibrostenosis. In contrast, Rag-/-Dr3-/- demonstrated decreased inflammation and fibrosis. Despite similar clinical disease and inflammation as Rag-/-, Rag-/-Dr3∆Col1a2 exhibited reduced intestinal fibrosis and attenuated fibroblast activation and migration. RNA-Sequencing of TL1A-stimulated fibroblasts identified Rho signal transduction as a major pathway activated by TL1A and inhibition of this pathway modulated TL1A-mediated fibroblast functions. Thus, direct TL1A signaling on fibroblasts promotes intestinal fibrosis in vivo. These results provide novel insight into profibrotic pathways mediated by TL1A paralleling its pro-inflammatory effects.
Implementation of a Clinical Pharmacist in a Hemodialysis Facility: A Quality Improvement Report

Rationale & Objective Hemodialysis (HD) patients have complicated disease states, placing them at higher risk for medication-related problems, medication discrepancies, and nonadherence. The objective of this study is to evaluate the impact of a clinical pharmacist in a single HD facility by assessing the efficacy of medication reconciliation in HD patients and evaluating the potential impact on a single health care system. Study Design Retrospective study. Setting & Participants Greenfield Health Systems, a wholly owned subsidiary of Henry Ford Health System, operates 14 HD facilities throughout Southeast Michigan. The West Pavilion facility is located in Detroit, MI. Patients with end-stage kidney disease included in the study had a minimum of 4 encounters with the clinical pharmacist or pharmacy interns between August 2017 and October 2018. Exposure A clinical pharmacist performed medication reconciliation and medication reviews with HD patients to assess medication-related problems and identify gaps in care. Interventions made by the pharmacist were prespecified through a collaborative practice agreement. Outcomes To evaluate the impact of a clinical pharmacist in an HD facility by assessing the efficacy of medication reconciliation in HD patients and evaluating the potential impact on this health system through an estimated cost avoidance. Analytical Approach Descriptive statistics were used to collect medication-related problems and classified based on a modified Hepler-Strand approach. Results There were 1,403 medication-related problems, with an average of 8.96 medication-related problems per patient. Adherence was the most common medication-related problem (31%). Antihypertensive medication was the most common drug class in which the pharmacist intervened (37%), followed by vitamin D analogues and calcimimetics (29%). A projected total of US $447,355 was saved. Limitations Retrospective analysis of observational data and descriptive statistics with the potential for residual bias and confounding. Conclusions Pharmacists in HD facilities have a positive influence on HD patients through medication management that results in cost savings.
Preoperative and Postoperative Opioid Dependence in Patients Undergoing Anterior Cervical Diskectomy and Fusion for Degenerative Spinal Disorders.

Background Anterior cervical diskectomy and fusion (ACDF) is a procedure for effectively relieving radiculopathy. Opioids are commonly overprescribed in postsurgical settings and prescriptions vary widely among providers. We identify trends in opioid dependence before and after ACDF. Methods We used the Truven Health MarketScan data to identify adult patients undergoing ACDF for degenerative cervical spine conditions between 2009 and 2015. Patients were segregated in four cohorts of preoperative and postoperative opioid nondependence (ND) or dependence (D) with 15 months of postoperative follow-up. Results A total of 25,403 patients with median age of 52 years (18–92) who underwent ACDF met the inclusion criteria. Breakdown of the four cohorts was as follows: prior nondependent who remain nondependent (NDND): 62.76% (n = 15,944); prior nondependent who become dependent (NDD): 4.6% (n = 1,168); prior dependent who become nondependent (DND): 14.03% (n = 3,564); and prior dependent who remain dependent (DD): 18.61% (n = 4,727). Opioid dependence decreased 9.43% postoperatively. Overall payments and 30-day readmissions increased 1.96 and 1.79 times for opioid dependent versus nondependent cohorts, respectively. Adjusted payments at 3 to 15 months were significantly increased for dependent cohorts with 3.56-fold increase for the DD cohort when compared with the NDND cohort. Length of stay, complications, medication refills, outpatient measures, and hospital admissions were also higher in those groups with postoperative opioid dependence when compared with those who were not opioid dependent. Conclusions Opioid dependence after ACDF is associated with increased hospital readmissions, complication rates at 30 days, and payments within 3 months and 3 to 15 months postdischarge. Overall opioid dependence was decreased after ACDF procedure, however, a smaller number of opioid-dependent and opioid-naive patients became dependent postoperatively and should be followed carefully.
Analysis of Multi-dimensional factors sensitive to comprehensive utilization of power distribution equipment

Considering the contradiction between high loading and long life, and the diversity of influencing factors, the decision making of improving utilization of distribution equipment is a complicated non-mechanism modeling problem. To make the measures on utilization improvement of distribution equipment more effectively and efficiently, a data-based analysis method of multi-dimensional factors sensitive to comprehensive utilization is proposed. Firstly, a multi-dimensional grid-load-management index system of influencing factors is constructed. Secondly, based on the concepts of capacity factor and lifecycle management, the comprehensive utilization index considering utilization of in-service equipment and retired equipment in a certain assessing period is defined, and calculated by entropy weight method. And then multiple linear regression algorithm is used to analyze the sensitivity of various influencing factors, and then conducts multilevel benchmarking evaluation is performed to screen the key influencing factors. The feasibility of the proposed method is verified by actual system case, which provides technical support for precise strategy making of comprehensive utilization improvement for distribution system.
Teacher's pet: understanding and mitigating biases in distillation.

Knowledge distillation is widely used as a means of improving the performance of a relatively simple student model using the predictions from a complex teacher model. Several works have shown that distillation significantly boosts the student's overall performance; however, are these gains uniform across all data subgroups? In this paper, we show that distillation can harm performance on certain subgroups, e.g., classes with few associated samples. We trace this behaviour to errors made by the teacher distribution being transferred to and amplified by the student model. To mitigate this problem, we present techniques which soften the teacher influence for subgroups where it is less reliable. Experiments on several image classification benchmarks show that these modifications of distillation maintain boost in overall accuracy, while additionally ensuring improvement in subgroup performance.
Use of Rituximab for persistent EBV DNAemia, and Its effect on donor-specific antibody development in pediatric renal transplant recipients: A case series.

Introduction Persistent EBV DNAemia (PEBV) is associated with late-onset PTLD. The efficacy of rituximab in PEBV is not conclusive. We monitored PEBV and DSA in pediatric kidney transplant patients with or without rituximab. Methods 13 PEBV patients received standard treatment with immunosuppression reduction and valganciclovir, with or without IVIG; 5/13 were further treated with rituximab. Results All Rituximab-treated and 6/7 No-Rituximab patients were EBV seronegative at transplant and seroconverted post-transplant. Peak EBV PCR levels were lower in No-Rituximab than Rituximab patients and all No-Rituximab patients cleared PEBV after standard treatment. Additional 1-2 doses of rituximab reduced EBV PCR levels in all 5 Rituximab patients, 3 cleared PEBV. One No-Rituximab patient developed localized PLTD. None of Rituximab patients developed de novo DSA, while 4/8 No-Rituximab patients did: 2/4 had ABMR. 1/5 Rituximab and 5/8 No-Rituximab patients had acute rejection. There was no change in eGFR between pre-EBV DNAemia and follow-up in Rituximab patients, while reduction in No-Rituximab patients was found. There was no difference in graft and patient survival. Conclusions While early intervention with rituximab in pediatric patients with PEBV may reduce viral load and PTLD, we observed a slower development of de novo DSA, and rejection and maintenance of eGFR.
Hollywood and Journalistic Truthtelling

MATTHEW C. EHRLICH Movies are useful tools for thinking about professional behavior and ethics. For example, films about lawyers can “raise questions about the proper and possible role of law in society”* while reflecting “powerful myths that influence our reactions to issues we meet in real life, including legal issues.” The same applies to journalism. Media ethics professor Lee Wilkins notes that “journalists are often called upon to make decisions based on a morally mature interpretation of principles rather than any specific code of conduct,” and she says film gives dramatic life to struggles over those principles. This article will look at what has been called the paramount principle of journalism—truthtelling—as it is depicted in a movie about a notorious real-life case of journalistic deception. Shattered Glass is the story of Stephen Glass, who in 1998 was fired for fabricating more than two dozen stories for the New Republic magazine. Writerdirector Billy Ray chose to focus his film more on the editor who fired Glass, Charles “Chuck” Lane, than on Glass himself. As a result, the movie turns a story of press ignominy into one of triumph, presenting a morality tale in which the hero upholds journalistic virtue and the villain is summarily banished. Similar to other journalism movies, Shattered Glass reaffirms notions of individual responsibility and professional
Additional data on the treatment of uterine bleeding with snake venom

Abstract In a previous report the therapeutic effects of moccasin venom (Ancistrodon piscivorus) in twelve cases of functional uterine bleeding were presented. 1 The clinical results obtained warranted further trial in cases of this kind. The present report embodies subsequent observations on some of the cases already reported, with the addition of new cases.
Starting from scratch: growing longest common subsequences with evolution

An evolutionary algorithm (EA) usually initializes its population with random genotypes, which represent random solutions to the target problem instance. If the problem is one of constrained optimization, an initial population whose genotypes all represent empty solutions might allow the EA to grow valid solutions as much as search for them and thereby identify good solutions more quickly. This is the case in a genetic algorithm (GA) for the longest common subsequence problem, which seeks the length of a longest subsequence common to each of a set of given strings. The GA encodes sequences as binary strings that indicate subsequences of the shortest or first given string. In tests on a variety of problem instances, the GA always identifies an optimum subsequence, but on most instances, the GA reaches an optimum more quickly when its initial population encodes empty sequences than when its initial genotypes represent random sequences.
Phototherapy for Neonatal Hyperbilirubinemia: Six-Year Follow-up of the National Institute of Child Health and Human Development Clinical Trial

The National Institute of Child Health and Human Development Randomized, Controlled Trial of Phototherapy for Neonatal Hyperbilirubinemia was conducted to determine whether phototherapy used to control serum bilirubin is safe and is as effective in preventing brain injury as exchange transfusion. The study, conducted at six neonatal care centers, randomly assigned 1339 newborn infants to phototherapy or control groups by the following subgroups: (1) birth weight less than 2000 g; (2) birth weight 2000 to 2499 g and bilirubin level greater than 171 mumol/L (10 mg/dL); or (3) birth weight greater than or equal to 2500 g and bilirubin level greater than 222 mumol/L (13 mg/dL). Phototherapy was administered for 96 hours, and exchange transfusion was used to control hyperbilirubinemia at the same predetermined levels in both groups. Neurological and developmental examinations were conducted at 1 and 6 years of age, with follow-up rates of 83% and 62%, respectively. The two groups did not differ in mortality or diagnosed medical conditions. The phototherapy and control groups had similar rates of cerebral palsy (5.8% vs 5.9%), other motor abnormalities including clumsiness and hypotonia (11.1% vs 11.4%), and sensorineural hearing loss (1.8% vs 1.9%). The Wechsler Intelligence Scale for Children-Revised scores overall were not significantly different for the two groups (Verbal, 96.8 vs 94.8; Performance, 95.8 vs 95.1 for phototherapy and control groups, respectively). Phototherapy effectively controlled neonatal hyperbilirubinemia without evidence of adverse outcome at 6 years of age and was at least as effective as management with exchange transfusion alone.
Use of transposase and ends of IS608 enables precise and scarless genome modification for modulating gene expression and metabolic engineering applications in Escherichia coli

Various methods have been developed for gene disruption in bacteria; however, extra in vitro manipulation steps or the residual presence of a scar in the host chromosome limits the use of such methods. By utilizing the unique properties of ISHp608, we have developed a simple and precise method for genome manipulation in Escherichia coli that alters the gene sequence without leaving foreign DNA in the chromosome. This strategy involves PCR amplification of a DNA cassette containing ISHp608-LE (left end)-antibiotic resistance gene-counterselection marker-ISHp608-RE (right end) by using primers containing extensions homologous to the adjacent regions of the target gene on the chromosome. The λ Red mediated recombination of the PCR product and antibiotic resistance screening results in transformants with a modified gene target. The ISHp608-LE-antibiotic resistance gene-counterselection marker-ISHp608-RE cassette can then be excised using a temperature sensitive plasmid expressing the TnpA transposase, which precisely cleaves ISHp608-LE and ISHp608-RE without leaving a scar sequence. We demonstrated lacZ gene point mutation repair, two precise disruptions of the lacZ gene and constructed a library of lacZ variants having variable β-galactosidase activity by changing its ribosome binding site sequences using the ISHp608 system. This technique can be used in E. coli genome modification and could be extended for use in other bacteria.
Correlated load-address predictors

As microprocessors become faster, the relative performance cost of memory accesses increases. Bigger and faster caches significantly reduce the absolute load-to-use time delay. However, increase in processor operational frequencies impairs the relative load-to-use latency, measured in processor cycles (e.g. from two cycles on the Pentium® processor to three cycles or more in current designs). Load-address prediction techniques were introduced to partially cut the load-to-use latency. This paper focuses on advanced address-prediction schemes to further shorten program execution time.Existing address prediction schemes are capable of predicting simple address patterns, consisting mainly of constant addresses or stride-based addresses. This paper explores the characteristics of the remaining loads and suggests new enhanced techniques to improve prediction effectiveness:• Context-based prediction to tackle part of the remaining, difficult-to-predict, load instructions.• New prediction algorithms to take advantage of global correlation among different static loads.• New confidence mechanisms to increase the correct prediction rate and to eliminate costly mispredictions.• Mechanisms to prevent long or random address sequences from polluting the predictor data structures while providing some hysteresis behavior to the predictions.Such an enhanced address predictor accurately predicts 67% of all loads, while keeping the misprediction rate close to 1%. We further prove that the proposed predictor works reasonably well in a deep pipelined architecture where the predict-to-update delay may significantly impair both prediction rate and accuracy.