cssi/SciSciGPT-SciSciNet huggingface dataset:
Simple post-processing technique to tune resonant frequency of film bulk acoustic resonators and stacked crystal filters

This paper describes a simple post-processing technique to tune the resonant frequency of an Al-ZnO-Al thickness-excitation film bulk acoustic resonator (FBAR) and stacked crystal filters built on a low-stress silicon nitride membrane after fabrication. The post-fabrication technique uses a reactive ion etching (RIE) to remove a portion of the silicon nitride membrane. This simple, mask-less, technique tunes the resonant frequency by about 10% with a variation of within 0.2% over a 1.2 cm-square area (a typical chip size) in our RIE system, and also allows us to match the resonant frequency within 0.01% of the desired value. For a typical resonator with the fundamental resonant frequency around 1 GHz (that uses 0.8 /spl mu/m thick silicon nitride membrane, 0.2 /spl mu/m thick Al electrodes, 2.3 /spl mu/m thick ZnO), a 10% frequency tuning is obtained by removing about 0.45 /spl mu/m the nitride support membrane from the backside of the wafer. The nitride removal is typically done in about 12 minutes with CF/sub 4/ RIE at 100 Watts. The fQ factor of the resonator increases by about 5-8% after the nitride removal from a value of about 8.5/spl times/10/sup 11/ with quality factors in the range of 900. With this technique, we have achieved about 8% tuning of the center frequency (550 MHz) of the stacked crystal filters which have the loaded insertion loss of less than 5 dB in a 50 /spl Omega/ system. We have accurately simulated the tuning effect by modeling the resonator with cascaded transmission lines derived from the Mason's model.
An adaptive RTS/CTS control mechanism for IEEE 802.11 MAC protocol

We study the impact of using or disengaging the RTS/CTS dialogue in IEEE 802.11 DCF MAC protocol under the fact that carrier sensing, transmission and interference ranges are distinctively different. The resulting throughput performance features of a linear topology network configuration are demonstrated when applying constant bit rate (CBR) UDP as well as TCP type traffic flows. Based on these results, we propose a new RTS/CTS control mechanism. Under our scheme, a terminal node decides dynamically and individually whether to use a RTS/CTS dialogue for the transmission of its current data packet. We show that this new mechanism yields distinctive performance improvements.
Position sensing using pico-second timing with Micro-Channel Plate devices and waveform sampling

Micro-Channel Plate devices (MCP) provide fast signals with rise-times in the 100 ps range, allowing a measurement of the time-of-arrival of light pulses with a few pico-seconds accuracy using either constant fraction discrimination followed by time-to-digital conversion, or waveform sampling processed after digitization. The coupling of the MCP anode plane to 50 Ω transmission lines allows both a precise time measurement and additionally the potential for a position measurement with an accuracy of a few hundred microns for large-area devices. We present position measurement results obtained with MCPs from Photonis, 10-cm transmission lines, and a calibrated laser source followed by sampling and digitization, and waveform analysis. A detailed simulation of the transmission lines is presented. We compare the measured position resolution for two identical setups but with MCPs of different pore diameters: 25 and 10 microns. Simulation results are also presented for transmission lines up to 1-m in length.
The Dissipation of Trapped Lee Waves. Part II: The Relative Importance of the Boundary Layer and the Stratosphere

AbstractDecaying trapped waves exert a drag on the large-scale flow. The two most studied mechanisms for such decay are boundary layer dissipation and leakage into the stratosphere. If the waves dissipate in the boundary layer, they exert a drag near the surface, whereas, if they leak into the stratosphere, the drag is exerted at the level where the waves dissipate aloft. Although each of these decay mechanisms has been studied in isolation, their relative importance has not been previously assessed.Here, numerical simulations are conducted showing that the relative strength of these two mechanisms depends on the details of the environment supporting the waves. During actual trapped-wave events, the environment often includes elevated inversions and strong winds aloft. Such conditions tend to favor leakage into the stratosphere, although boundary layer dissipation becomes nonnegligible in cases with shorter resonant wavelengths and higher tropopause heights. In contrast, idealized two-layer profiles with ...
Activation of epithelial Na channels during short-term Na deprivation

The role of epithelial Na channels in the response of the kidney to short-term Na deprivation was studied in rats. Animals were fed either a control-Na (3.9 g/kg) or a low-Na ( 3.8 mg/kg) diet for ...
Enhancing learning and engagement through embodied interaction within a mixed reality simulation

Computer simulations have been shown to be effective instruments for teaching students about difficult concepts, particularly in the STEM disciplines. Emerging interface technologies are expanding the modalities with which learners can interact with these simulations, but the effects of these new interactions on conceptual understanding and student engagement have not been examined in great depth. We present here a study where middle school students learned about gravity and planetary motion in an immersive, whole-body interactive simulation, and we compared their learning and attitudes about science with students who used a desktop version of the same simulation. Results of the study indicate that enacting concepts and experiencing critical ideas in physics through whole-body activity leads to significant learning gains, higher levels of engagement, and more positive attitudes towards science. Mixed reality technologies allow for embodied interaction with science content.Whole-body interaction enhances learning of physics concepts.Compared to traditional simulations, embodied interaction leads to higher engagement.Whole-body interaction with simulations increases positive attitudes toward science.
Mindful Eating: Principles and Practice

Mindful eating is the enjoyment of food utilizing all of the senses without judgment. The basic principles of mindful eating involve listening to internal cues of the body (ie, hunger and satiety) to avoid overconsumption and utilizing external cues (reducing portion sizes and distractions while eating, and eating slowly) to assist in achieving awareness. Some practical ways of incorporating mindful eating include chewing food thoroughly before swallowing, drinking water between bites of food, savoring the aroma and taste of food, using smaller plates and bowls, turning off the television and computer while eating, and creating a pleasurable experience around food and eating.
Influenza Virus-Membrane Fusion Triggered by Proton Uncaging for Single Particle Studies of Fusion Kinetics

We report a method for studying membrane fusion, focusing on influenza virus fusion to lipid bilayers, which provides high temporal resolution through the rapid and coordinated initiation of individual virus fusion events. Each fusion event proceeds through a series of steps, much like multistep chemical reaction. Fusion is initiated by a rapid decrease in pH that accompanies the "uncaging" of an effector molecule from o-nitrobenzaldehyde, a photoisomerizable compound that releases a proton to the surrounding solution within microseconds of long-wave ultraviolet irradiation. In order to quantify pH values upon UV irradiation and uncaging, we introduce a simple silica nanoparticle pH sensor, useful for reporting the pH in homogeneous nanoliter volumes under conditions where traditional organic dye-type pH probes fail. Subsequent single-virion fusion events are monitored using total internal reflection fluorescence microscopy. Statistical analysis of these stochastic events uncovers kinetic information about the fusion reaction. This approach reveals that the kinetic parameters obtained from the data are sensitive to the rate at which protons are delivered to the bound viruses. Higher resolution measurements can enhance fundamental fusion studies and aid antiviral antifusogenic drug development.
Exploring Ethical Leadership

Brown (2007) has described ethical leadership as “the demonstration of normatively appropriate conduct through personal actions and interpersonal relationships, and the promotion of such conduct to followers through two-way communication, reinforcement, and decision making” (p. 141). Kanungo (2001) has noted that “ethical leaders engage in acts and behaviors that benefit others, and at the same time, they refrain from behaviors that can cause any harm to others” (cited in Yukl, Mahsud, Hassan, & Prussia, 2013, p. 38). This paper explores the topic of ethical leadership. It investigates the following questions: What is ethical leadership? What is ethical leadership behavior? What is unethical leadership behavior? What are the benefits of ethical behavior? What are the characteristics of an ethical leader? What misconceptions about ethical leadership exist? What mistakes must leaders avoid to ensure sound business ethics? How is ethical leadership sustained - how do organizations promote ethical leadership?
Electrical Variable Propeller Pitch System of Megawatt Wind Turbine Based on Real-time Industrial Ethernet

The demand for Industrial Ethernet as a real-time control network is increasing as manufacturers realize the benefits of employing a single network technology from the boardroom to the plant floor.Variable speed wind turbines with active pitch control system are most favorable and prevailing nowadays.This thesis makes a research on the feasibility of applying Ethernet in electrical variable propeller pitch system.Based on integrated Ethernet POWERLINK,communication and control advantages of pitch drive are discussed.The test platform of pitch system based on motor load,including the system structure,components and its relevant results is also introduced in the paper.
The hemoglobin D syndromes.

The clinical and hematologic manifestation of the Hgb D trait and homozygous Hgb D disease have been presented. Family studies suggest that Hgb D is transmitted in a manner identical to that of Hgb A.
Dotter Interventional Institute 1990–2015

Charles T. Dotter died on February 15, 1985 following his second aortocoronary bypass surgery. According to his wishes, there was no funeral. He was cremated and his ashes were scattered on Mt. Hood, the place that he loved so much. But, memories of Charles remain in our hearts.
Optical Filters for TV-Induced Photosensitive Epilepsy

Two different types of optical filters were tested in 20 photosensitive epileptic patients for ability to inhibit photoparoxysmal response (PPR) and seizures, in a study at Gifu Prefectural Gifu Hospital, Japan.
Should a Spinal Be Used for Surgical Anesthesia After a Failed Labor Epidural

The obstetrical team (OB) calls the anesthesia resident to inform him that one of the laboring patients will have a cesarean delivery for failure to progress. The anesthesia resident calls his attending: “I am calling to discuss our 24-year-old G1P0 parturient in labor room 8 who will be having a cesarean delivery for failure to progress. The patient’s medical history is significant only for obesity. She denies any surgeries in the past. Her airway examination reveals a Mallampati 3, with good mouth opening, normal thyromental distance, full range of motion, and a short, thick neck. We placed her epidural this morning, and I have been asked to give additional medication (top-up) three times since then.
Correlates and Consequences of Prenatal Cannabis Exposure (PCE): Identifying and Characterizing Vulnerable Maternal Populations and Determining Outcomes for Exposed Offspring

Cannabis is the illicit drug that is most abused during pregnancy worldwide, resulting in prenatal exposure rates of ∼ 5–15% of the total population. Many challenges exist in detecting prenatal cannabis exposure (PCE) in the obstetric patient population, in understanding the motivation to use cannabis during pregnancy, and in determining the effects of PCE on offspring. This chapter summarizes the scientific literature regarding the prevalence of PCE, and the detection methods used to estimate exposure prevalence. The characteristics of pregnant women who are most vulnerable to using cannabis are also described. Finally, the effects of PCE on the childhood course of physical, neurological, cognitive, behavioral, and emotional development are discussed. The purpose of the current chapter is to inform readers about the potentially negative impact of PCE at both the individual and societal level, by providing reliable, scientifically valid, peer-reviewed information on this controversial subject.
Mediating the Relationship Between Parental Control/Support and Offspring Delinquency: Self-Efficacy for a Conventional Lifestyle Versus Self-Efficacy for Deviance:

This study sought to determine whether self-efficacy for a conventional lifestyle mediated the relationship between parental control/support and offspring delinquency using longitudinal data suppli...
Effect of post-polymerization anion-exchange on the rejection of uncharged aqueous solutes in nanoporous, ionic, lyotropic liquid crystal polymer membranes

Abstract The selectivity of a bicontinuous cubic, lyotropic liquid crystal (LLC) polymer nanofiltration membrane containing uniform cationic nanopores was manipulated via anion-exchange at the pore wall by soaking the fabricated membranes in aqueous salt solutions. Monovalent organosulfonate anions of various sizes were completely exchanged as the counterion at the pore walls to explore the impact of anion size on uncharged molecular solute rejection and water permeance. It was found that larger organosulfonate anions associated at the pore walls induced a higher rejection of uncharged solutes and a lower water permeance. The change in selectivity of the nanopores was described quantitatively through the calculation of the effective pore radius. The effective pore radius in these modified membranes was found to vary from 0.9±0.2 to 0.55±0.08 nm depending on the resident organosulfonate counterion, demonstrating sub-1-nm resolution in pore size manipulation. An empirical model was used to demonstrate that physicochemical properties (molecular volume and hydrophobicity) of the resident counterion correlate with the observed solute rejection, suggesting that the counterion can be chosen to target a desired membrane performance. The ability to manipulate uniform, nm-sized pores with sub-1-nm resolution via simple anion-exchange offers a new avenue to tailor nanofiltration membrane performance.
Designing Graphene-Based Absorber by Using HIE-FDTD Method

A hybrid implicit explicit-finite-difference time-domain (HIE-FDTD) method is used to simulate a graphene-based absorber. Both the interband conductivity and intraband conductivity of the graphene are incorporated into the HIE-FDTD method directly through an auxiliary difference equation. Because the time step size in the proposed method is not confined by the fine spatial cells in the graphene layer, the simulation time of the proposed method is greatly reduced compared with that of the conventional FDTD method. By using the proposed HIE-FDTD method, a graphene-based absorber is simulated and analyzed. The numerical result shows that the operating frequency of the absorber is tunable through controlling graphene’s chemical potential. It also shows that the interband conductivity has an important effect on the performance of the graphene device, especially at the frequency band larger than 10 THz.
Abstract 251: Long-term Outcomes and Implantable Cardioverter Defibrillator Use in Peripartum Cardiomyopathy

Background: Many studies of outcomes in peripartum cardiomyopathy (PPCM) are limited by short-term follow-up of 6-12 months. Long-term mortality rates and outcomes are largely unknown. Prior research has also suggested under-utilization of implantable-cardioverter defibrillators (ICD) in this population. Methods: Patients with PPCM at a tertiary care center were retrospectively identified using ICD9 code 674.5x from 2000-2011, and each chart was manually reviewed. Clinical, demographic, and echocardiographic data were reviewed, with follow-up through November 2016. Recovery was defined as ejection fraction (EF) >= 55%. Results: Of 60 patients, 35 were white (58.3%) and 16 were black (26.7%). Mean age at diagnosis was 29.6 years (range 18-44 years) and average follow-up was 5.8 years. Mean EF at time of diagnosis was 20.2 +/- 4%, at 6-months follow-up it was 39.6 +/- 4%, and at final follow-up was 38.7 +/- 3%. Recovery (EF>=55%) occurred in 38%. Of those who did not recover (62%), the final mean EF was 25%. ICD was placed in 19 patients (51%). Only one patient with an ICD later recovered at one year follow-up. LVAD or transplant occurred in 8 patients, and death occurred in 7 patients with a mean survival of 4.4 +/- 1.4 years. Five patients experienced subsequent deterioration in their EF (with a range of 10-35%) in the absence of a subsequent pregnancy, with a mean decrease in EF of 23.2%. Three of these patients had achieved full recovery (EF>=55%) prior to subsequent decline. Conclusions: Patients with PPCM who have initial improvement in EF or even full recovery, can later suffer deterioration, even in the absence of subsequent pregnancy. This finding warrants continued surveillance and raises the question whether lifelong medical therapy may be indicated despite recovery. This study also shows a higher rate of ICD utilization than prior reports.
Networks Underpinning Symbiosis Revealed Through Cross-Species eQTL Mapping

Organisms engage in extensive cross-species molecular dialog, yet the underlying molecular actors are known for only a few interactions. Many techniques have been designed to uncover genes involved in signaling between organisms. Typically, these focus on only one of the partners. We developed an expression quantitative trait locus (eQTL) mapping-based approach to identify cause-and-effect relationships between genes from two partners engaged in an interspecific interaction. We demonstrated the approach by assaying expression of 98 isogenic plants (Medicago truncatula), each inoculated with a genetically distinct line of the diploid parasitic nematode Meloidogyne hapla With this design, systematic differences in gene expression across host plants could be mapped to genetic polymorphisms of their infecting parasites. The effects of parasite genotypes on plant gene expression were often substantial, with up to 90-fold (P = 3.2 × 10-52) changes in expression levels caused by individual parasite loci. Mapped loci included a number of pleiotropic sites, including one 87-kb parasite locus that modulated expression of >60 host genes. The 213 host genes identified were substantially enriched for transcription factors. We distilled higher-order connections between polymorphisms and genes from both species via network inference. To replicate our results and test whether effects were conserved across a broader host range, we performed a confirmatory experiment using M. hapla-infected tomato. This revealed that homologous genes were similarly affected. Finally, to validate the broader utility of cross-species eQTL mapping, we applied the strategy to data from a Salmonella infection study, successfully identifying polymorphisms in the human genome affecting bacterial expression.
Lower urinary tract obstruction: fetal intervention based on prenatal staging

The authors present an overview of lower urinary tract obstruction (LUTO) in the fetus with a particular focus on the insult to the developing renal system. Diagnostic criteria along with the challenges in estimating long-term prognosis are reviewed. A proposed prenatal LUTO disease severity classification to guide management decisions with fetal intervention to maintain or salvage in utero and neonatal pulmonary and renal function is also discussed. Stage I LUTO (mild form) is characterized by normal amniotic fluid index after 18 weeks, normal kidney echogenicity, no renal cortical cysts, no evidence of renal dysplasia, and favorable urinary biochemistries when sampled between 18 and 30 weeks; prenatal surveillance is recommended. Stage II LUTO is characterized by oligohydramnios/anhydramnios, hyperechogenic kidneys but absent renal cortical cysts or apparent signs of renal dysplasia and favorable fetal urinary biochemistry; fetal vesicoamniotic shunting (VAS) or fetal cystoscopy is indicated to prevent pulmonary hypoplasia and renal failure. Stage III LUTO is oligohydramnios/anhydramnios, hyperechogenic kidneys with cortical cysts and renal dysplasia and unfavorable fetal urinary biochemistry after serial evaluation; fetal vesicoamniotic shunt may prevent severe pulmonary hypoplasia but not renal failure. Stage IV is characterized by intrauterine fetal renal failure, defined by anhydramnios and ultrasound (US) findings suggestive of severe renal dysplasia, and is associated with death in 24 h of life or end-stage renal disease (ESRD) within the first week of life; fetal vesicoamniotic shunt and fetal cystoscopy are not indicated.
Multiscale modeling and analysis of graphene nanoplatelet/carbon fiber/epoxy hybrid composite

Abstract The elastic response of Graphene Nano Platelet/carbon fiber/epoxy hybrid composite was investigated using multiscale modeling and analysis. The importance of volume fraction of graphene, GNP dispersion, and strain rates on the mechanical behaviors was determined. The analysis entailed the building of computational molecular dynamic model, involving multilayer graphene nano-platelets in epoxy composite, and micromechanical modeling. The predicted results show that the elastic responses of the hybrid composite increase with increased GNP volume fraction, dispersion, and strain rates.
Myeloid cell neuropilin 1 ameliorates high-fat diet-induced insulin resistance via suppression of Nlrp3 inflammasome.

The history of neuropilin 1 (Nrp1) research is checkered with many unexpected and exciting findings. Originally identified as a co-receptor for class 3 semaphorins, and several canonical growth factors, Nrp1 was shown to play important roles in the development of central nervous system, and angiogenesis within neuronal and endothelial cells , respectively. Accumulating evidence demonstrates that Nrp1 is also highly expressed in immune cells, including macrophages and dendritic cells. Until now, the functions of Nrp1 within these cells remained poorly studied and elusive. In this research highlight, we provide exciting insights on our recently published study that identified a novel role for myeloid cell Nrp1 in the mitigation of high -fat diet-induced insulin resistance via suppression of Nlrp3 inflammasome.
What democracy looks like: crowd-collecting protest materials

ABSTRACTMass political protests have emerged as a persistent theme in the presidency of Donald Trump, among them, the 300+ Women’s Marches that occurred worldwide on 21 January 2017. Collecting by curatorial staff at protests is an existing, although sometimes controversial, practice. However, in the era of social media, crowd-collecting has also become common practice. This Forum article summarizes the history and practice in museums and identity-based archives and proposes protocols for documenting artifacts acquired by protest participants.
Security and Machine Learning

Machine learning has seen increasing use for a wide range of practical applications. What are the security implications of relying upon machine learning in these settings? Recent research suggests that modern machine learning methods are fragile and easily attacked, which raises concerns about their use in security-critical settings. This talk will explore several attacks on machine learning and survey directions for making machine learning more robust against attack.
GNSS-R delay-Doppler maps of ocean surface at weak winds

Currently used models for calculation of delay-Doppler maps (DDM) of ocean reflected signals produced by Global Navigation Satellites System (GNSS) frequently rely on the Kirchhoff Approximation in a Geometric Optics limit. These models are usually assume strong diffuse scattering typical for ocean wind-driven waves for moderate and strong winds. These models will produce an incorrect result if to extend them to the case of weak, or even moderate diffuse scattering. To correctly describe DDM under a transition from partially-coherent scattering to completely non-coherent, strong diffuse scattering a more complex formulation of the bistatic radar cross section (BRCS) is needed. Here, the GNSS-R DDMs at weak ocean winds resulted from BRCS obtained with the small slope approximation of the first order (SSA1) are demonstrated, and their behavior is discussed.
Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening.

Abstract Zika virus (ZIKV), an emerging arbovirus, has become a major human health concern globally due to its association with congenital abnormalities and neurological diseases. Licensed vaccines or antivirals against ZIKV are currently unavailable. Here, by employing a structure-based approach targeting the ZIKV RNA-dependent RNA polymerase (RdRp), we conducted in silico screening of a library of 100,000 small molecules and tested the top ten lead compounds for their ability to inhibit the virus replication in cell-based in vitro assays. One compound, 3-chloro-N-[({4-[4-(2- t hienylcarbonyl)-1- p iperazinyl]phenyl}amino)carbonothioyl]-1- b enzothiophene-2-carboxamide (TPB), potently inhibited ZIKV replication at sub-micromolar concentrations. Molecular docking analysis suggests that TPB binds to the catalytic active site of the RdRp and therefore likely blocks the viral RNA synthesis by an allosteric effect. The IC50 and the CC50 of TPB in Vero cells were 94 nM and 19.4 μM, respectively, yielding a high selective index of 206. In in vivo studies using immunocompetent mice, TPB reduced ZIKV viremia significantly, indicating TPB as a potential drug candidate for ZIKV infections.
Flexible execution of plans with choice

Dynamic plan execution strategies allow an autonomous agent to respond to uncertainties while improving robustness and reducing the need for an overly conservative plan. Executives have improved this robustness by expanding the types of choices made dynamically, such as selecting alternate methods. However, in methods to date, these additional choices introduce substantial run-time latency. This paper presents a novel system called Drake that makes steps towards executing an expanded set of choices dynamically without significant latency. Drake frames a plan as a Disjunctive Temporal Problem and executes it with a fast dynamic scheduling algorithm. Prior work demonstrated an efficient technique for dynamic execution of one special type of DTPs by using an off-line compilation step to find the possible consistent choices and compactly record the differences between them. Drake extends this work to handle a more general set of choices by recording the minimal differences between the solutions which are required at run-time. On randomly generated structured plans with choice, we show a reduction in the size of the solution set of over two orders of magnitude, compared to prior art.
Long-distance REDOR NMR measurements for determination of secondary structure and conformational heterogeneity in peptides

High-resolution NMR spectroscopy of liquids has become a standard method for conformational studies in biochemistry. This method provides information on the secondary and tertiary structure of macromolecules and on intermolecular interactions such as ligand receptor binding. These determinations are based mainly on interatomic distance measurements by quantitative analysis of NOESY spectra and, to a lesser degree, on torsion angle measurements based on homoor heteronuclear scalar coupling constants. As with liquids, internuclear distances in solids are reflected in dipole-dipole coupling constants between the nuclear magnetic dipoles. Rotational-echo double resonance (REDOR) spectroscopy has been employed to determine heteronuclear dipole-dipole coupling constants [1,2] and to study internuclear distances in peptides, proteins and bound ligands. An important target for the REDOR experiment is an amorphous solid. For biologically important amorphous solids that cannot be obtained in crystalline form, NMR spectroscopy is the only method for direct investigation of conformation at the atomic level. In the present study we examine the REDOR of selectively labeled peptide hormone in lyophilized powders. In order to understand the contribution of naturalabundance nuclei to the REDOR data at long evolution times, we have used a three-body calculation [3,4] and assumed a spherical distance distribution for natural abundance corrections. In addition we have evaluated the REDOR results in terms of a superposition of different distances with appropriate weighting factors. These approaches allow us to fit the experimental data on the to a high degree of accuracy and to conclude that this peptide has a tendency to be bent in a lyophilized powder.
A Database Review in C-L-Psychiatry: Characteristics of Hospitalized Suicide Attempters

A computerized database was used to study the characteristics of psychiatric consultations in patients admitted to nonpsychiatric services. The authors reviewed a consultation practice with suicide attempters over a four- year period and compared the patients with a patient sample matched for gender and age also seen by the service. For suicide attempters, the time elapsed between admission to the service and the consultation, as well as the lengths of stay, were significantly shorter. Suicide attempters were significantly more likely to have mood disorders and Axis II disorders. The authors review the role of consultation psychiatrists with these patients and suggest that a triage model fits the services provided and the needs of nonpsychiatric physicians.
A 5V 6b, 80Ms/s BiCMOS Flash ADC

A single 5V, 6-bit Flash A/D converter (ADC) has been developed that supports sampling rates of up to 80 Ms/s. The design of the converter is optimised to operate in under-sampling applications where the ADC has to maintain performance with input frequencies well beyond Nyquist. Excellent dynamic linearity performance has been achieved with input frequencies of up to 75MHz and a gain flatness of better than 0.4dB is obtained over the input signal spectrum of 50MHz-75MHz. This ADC is fabricated on a 1.0?m advanced BiCMOS process that features trench-isolated bipolar devices with an f T of 10GHz.
CH, V = L, disintegration of measures, and ?? sets

Abstract In 1950 Maharam asked whether every disintegration of a σ-finite measure into σ-finite measures is necessarily uniformly σ-finite. Over the years under special conditions on the disintegration, the answer was shown to be yes. We show here that the question is equivalent to the existence of a Borel uniformization of a certain set defined from the disintegration. Moreover, we show that the answer may depend on the axioms of set theory in the following sense. If CH, the continuum hypothesis holds, then the answer is no. Our proof of this leads to some interesting problems in infinitary combinatorics. Also, if Godel's axiom of constructibility V = L holds, then not only is the answer no, but of equal interest is the construction of Π 1 1 sets with very special properties.
Five to Ten-Year Results of the Birmingham Hip Resurfacing Implant in the U.S.: A Single Institution's Experience.

Background:International surgeon series and registry data have demonstrated positive outcomes and long-term survival of the Birmingham Hip Resurfacing (BHR) implant. We report the 5 to 10-year results from a single center in the U.S.Methods:Three hundred and fourteen patients (360 hips) underwent su
The Indecent Body of Sculpture: Theodor Storm’s Realist Psyche

Stubbornly associated with eighteenth-century neoclassical aesthetics, in the nineteenth century sculpture comes under scrutiny as a species of obsolete, sensualistic object. This essay considers the ambivalent status of sculpture in German Realist Theodor Storm’s novella Psyche (1875). Storm’s text is preoccupied with questions of decency and indecency, questions that were raised not only by Storm himself, but by contemporary reviewers, as well as viewers of sculpture in the novella. Psyche, this chapter argues, flirts with the eroticism of antique sculpture, but also uses sculpture cathartically to dispel the indecency of its source. The chapter also considers the pairing of this classicizing Psyche with the grotesquely corporeal Nordic sculpture of a “Walkure,” a juxtaposition couched in strongly nationalist terms, in the years following German unification.
Neurosurgery Training Camp for Sub-Internship Preparation: Lessons From the Inaugural Course.

Objective Historically, medical student education in neurological surgery has generally limited student involvement to assisting in research projects with minimal formal clinical exposure before starting sub-internships and application for the neurosurgery match. Consequently, students have generally had little opportunity to acquire exposure to clinical neurosurgery and attain minimal proficiency. A medical student training camp was created to improve the preparation of medical students for the involvement in neurological surgery activities and sub-internships. Methods A 1-day course was held at Weill Cornell Medicine, which consisted of a series of morning lectures, an interactive resident lunch panel, and afternoon hands-on laboratory sessions. Students completed self-assessment questionnaires regarding their confidence in several areas of clinical neurosurgery before the start of the course and again at its end. Results A significant increase in self-assessed confidence was observed in all skill areas surveyed. Overall, rising fourth year students who were starting sub-internships in the subsequent weeks reported a substantial increase in their preparedness for the elective rotations in neurosurgery. Conclusions The preparation of medical students for clinical neurosurgery can be improved. Single-day courses such as the described training camp are an effective method for improving knowledge and skill gaps in medical students entering neurosurgical careers. Initiatives should be developed, in addition to this annual program, to increase the clinical and research skills throughout medical student education.
Metadherin Is a Prognostic Apoptosis Modulator in Mesothelioma Induced via NF-κB-Mediated Signaling.

Therapies against malignant pleural mesothelioma (MPM) have yielded disappointing results, in part, because pathologic mechanisms remain obscure. In searching for rational molecular targets, we identified metadherin (MTDH), a multifunctional gene associated with several tumor types but previously unrecognized in MPM. Cox proportional hazards regression analysis delineated associations between higher MTDH expression and lower patient survival from three independent MPM cohorts (n = 349 patients). Through in vitro assays with overexpression and downregulation constructs in MPM cells, we characterized the role of MTDH. We confirmed in vivo the phenotype of altered MTDH expression in a murine xenograft model. Transcriptional regulators of MTDH were identified by chromatin immunoprecipitation. Overexpression of both MTDH mRNA (12-fold increased) and protein levels was observed in tumor tissues. MTDH stable overexpression significantly augmented proliferation, invasiveness, colony formation, chemoresistance, and an antiapoptosis phenotype, while its suppression showed opposite effects in MPM cells. Interestingly, NF-κB and c-Myc (in a feed-forward loop motif) contributed to modulating MTDH expression. Knockdown of MTDH expression profoundly retarded xenograft tumor growth. Thus, our findings support the notion that MTDH integrates upstream signals from certain transcription factors and mediates pathogenic interactions contributing to MPM traits. MTDH represents a new MPM-associated gene that can contribute to insights of MPM biology and, as such, suggest other treatment strategies.
Build community before the storm: The National Weather Service's social media engagement

The current study examines crisis communication on social media by observing how twelve National Weather Service (NWS) offices use Twitter to facilitate engagement with stakeholders during threat and nonthreat periods. Using content analytic methods, we examine message features related to content and structure during a 3‐month period in spring 2016. We conduct chi‐square analyses to determine how the prevalence of these features varies by time. Results indicate that NWS offices use Twitter for ongoing engagement communication through both the content and structure of their messages, where community building and action‐orientated messages are primarily used during nonthreat periods. When fair weather changes and storms approach, the offices shift to the communication of risk. Our findings underscore the need to examine organizational communication practices in a manner that recognizes the distinctions between long‐term engagement goals and short‐term goals related to the mission of the organization.
Postoperative Complications After Robotic Partial Nephrectomy.

Objectives: To assess the incidence of postoperative arterial malformation (AM) and urine leak/urinoma (UL) after robotic partial nephrectomy (RPN) in a contemporary series and to evaluate risk fac...
DLFloat: A 16-b Floating Point Format Designed for Deep Learning Training and Inference

The resilience of Deep Learning (DL) training and inference workloads to low-precision computations, coupled with the demand for power-and area-efficient hardware accelerators for these workloads, has led to the emergence of 16-bit floating point formats as the precision of choice for DL hardware accelerators. This paper describes our optimized 16-bit format that has 6 exponent bits and 9 fraction bits, derived from a study of the range of values encountered in DL applications. We demonstrate that our format preserves the accuracy of DL networks, and we compare its ease-of-use for DL against IEEE-754 half-precision (5 exponent bits and 10 fraction bits) and bfloat16 (8 exponent bits and 7 fraction bits). Further, our format eliminated sub-normals and simplifies rounding modes and handling of corner cases. This streamlines floating-point unit logic and enables realization of a compact power-efficient computation engine.
Towards a Disarmed Cinema

In “Towards a Disarmed Cinema”, Morel begins by considering those theorists who claim that cinema commonly makes violence visible and peace invisible. To explore whether a different approach to film is possible, Morel considers the work of three film-makers who have attempted to “disarm cinema” during the past decade: Errol Morris, Rithy Panh and Joshua Oppenheimer. These examples show how film can change audience perceptions of overlooked “standard operating procedures” at the prison in Abu Ghraib, in the Khmer Rouge’s genocide in Cambodia, and in a largely forgotten massacre in Indonesia. For Morel, these and other film-makers can disarm cinema, by making the invisible visible, by opening a space for reconciliation and by envisaging a different kind of world from the one being presented.
CofActor: A light and redox-gated optogenetic clustering tool to study abnormal cytoskeletal dynamics in stressed cells

The biochemical hallmarks of neurodegenerative diseases (neural fibrils, clumps, and tangles; heightened reactive oxygen species (ROS); cofilin-actin rods) have presented numerous challenges for development of in vivo diagnostic tools. Biomarkers such as amyloid beta fibrils and Tau tangles in Alzheimers Disease (AD) are only accessible via invasive cerebrospinal fluid assay for peptide mass fingerprinting or post mortem diagnosis, while ROS can be fleeting and thus challenging to monitor in vivo. While remaining a challenge for in vivo detection, the unique protein-protein interactions underlying these disease-specific biomarkers also present rich opportunities for the engineering of in vitro pathology-sensitive biosensors and bioactuators. These tools can be useful for the investigation of critical, early stage events in neurodegenerative diseases in both cellular and animal models, while potentially leading to advanced detection reagents with clinical applications. In this report, we describe a light and redox-gated protein switch inspired by the phenomenon of cofilin-actin rod formation, which occurs in stressed neurons in the AD brain and following brain ischemia. By coupling the redox-sensitive interaction of actin and cofilin with the light responsive Cry2-CIB blue light switch, we accomplish both light- and ROS-gated control of this interaction. The resulting switch is referred to as the CofActor system. Site-directed mutagenesis of both cofilin and actin partners demonstrate which residues are critical for sustaining or abrogating the light and redox gated response. Furthermore, switch response varies depending on whether oxidative stress is generated via glycolytic inhibition or a combination of glycolytic inhibition and azide-induced oxidative stress. Finally, light and redox gated switch function was demonstrated in cultured hippocampal neurons. As a dual input biosensor, CofActor holds promise for the tracking of early stage events in neurodegeneration and the investigation of actin-binding protein interactions under oxidative stress.
Bowel Ultrasound for Predicting Surgical Management of Necrotizing Enterocolitis in Preterm Infants: A Meta-Analysis

Purpose: To evaluate, through a meta-analysis, abdominal ultrasound (AUS) findings that can be predictive for surgical management of necrotizing enterocolitis (NEC) in preterm infants. Methods: A literature search was performed using Embase, PubMed, and Cumulative Index of Nursing and Allied Health Literature. Studies reporting on AUS findings associated with surgical management of NEC were selected. We defined surgical management to include laparotomy …
General Approach to Lifting-Line Theory, Applied to Wings with Sweep

Implementations of lifting-line theory predict the lift of a finite wing using a sheet of semi-infinite vortices extending from a vortex filament placed along the locus of aerodynamic centers of th...
Multi-Site Assessment of Pediatric Bone Age Using Deep Learning

Pediatric bone age assessment is clinically valuable for the evaluation of a variety of pediatric endocrine and orthopedic conditions. Recent studies have explored automated methods for bone age assessment using machine learning techniques, yielding impressive results. However, many state-of-the-art methods rely on manual, fine-grained segmentation of phalanges and have not been validated on an external hospital site. The purpose of this study was to examine the efficacy of a deep learning algorithm for pediatric bone age assessment without the need for time-intensive segmentation. We utilize a novel training regime to achieve results on par with existing approaches, present a systematic analysis of experimental findings via an ablation study, and evaluate generalizability on an external dataset as a function of training data size. The final optimized model achieves mean absolute error of 7.59 months upon internal validation and 11.02 upon validation with data from an external hospital site.
DDK regulates replication initiation by controlling the multiplicity of Cdc45-GINS binding to Mcm2-7

Abstract The committed step of eukaryotic DNA replication occurs when the replicative Mcm2-7 helicase pairs that license each replication origin are activated. Helicase activation requires the recruitment of Cdc45 and GINS to Mcm2-7, forming Cdc45-Mcm2-7-GINS complexes (CMGs). Using single-molecule biochemical assays to monitor CMG formation, we found that Cdc45 and GINS are recruited to loaded Mcm2-7 in two stages. Initially, Cdc45 and GINS are individually recruited to unstructured Mcm2-7 N-terminal tails in a Dbf4-dependent kinase (DDK)-dependent manner, forming Cdc45-tail-GINS intermediates (CtGs). The multiple phosphorylation sites on the Mcm2-7 tails promote DDK-dependent modulation of the number of CtGs formed per Mcm2-7. In a second, inefficient event, a subset of CtGs transfer their Cdc45 and GINS components to form CMGs. Importantly, higher CtG multiplicity results in increased frequency of CMG formation. Our findings reveal molecular mechanisms sensitizing helicase activation to DDK levels with implications for the control of replication origin efficiency and timing.
Retention, Migration, and Engagement: An Analysis of a Large-Scale Multiplex Volunteer Collaboration Network

Volunteer engagement is improving the well-being of individuals in society, and volunteers' retention and migration behaviors are critical to the management of non-profit organizations. Despite the existing effort to understand organization performance with network science, no prior study has tapped into the behavior of the unpaid labor force of non-profit organizations. This work looks into volunteers' engagement, retention, and migration by constructing dynamic egocentric collaboration networks using data from 827,260 unique volunteers' participation in 183,445 projects initiated by 74,556 non-profit organizations over nine years. We apply a multiplex network framework to characterize the heterogeneous relationships within the collaboration networks. We find that volunteers embedded in more cohesive networks and surrounded by fewer structural holes (gaps between individuals who have complementary sources of information) are more likely to remain in their existing non-profit organizations. These volunteers are less likely to explore unfamiliar organizations through migration, and collectively, the reduced migration rates negatively affect the development of small and newly-established organizations. Further, such volunteers have a higher volunteering engagement level overall, guaranteeing the supply of the volunteer labor force. Our work not only adds to the theories of network cohesion and structural holes but also deepens the understanding of how collaboration networks pose opportunities and constraints for volunteer behaviors. This work provides rich implications for volunteer management and public policy.
Comparison of Surgical Resection and Systemic Treatment for Hepatocellular Carcinoma with Vascular Invasion: National Cancer Database Analysis

Introduction Small studies from outside of the USA suggest excellent outcomes after surgical resection for hepatocellular carcinoma (HCC) with vascular invasion. The study aims to (1) compare overall survival after surgical resection and systemic therapy among patients with HCC and vascular invasion and (2) determine factors associated with receipt of surgical resection in a US population. Methods HCC patients with AJCC clinical TNM stage 7th T3BN0M0 diagnosed between 2010 and 2017 from the National Cancer Database were analyzed. Cox and logistic regression analyses identified factors associated with overall survival and receipt of surgical resection. Results Of 11,259 patients with T3BN0M0 HCC, 325 (2.9%) and 4,268 (37.9%) received surgical resection and systemic therapy, respectively. In multivariable analysis, surgical resection was associated with improved survival compared to systemic therapy (adjusted hazard ratio: 0.496, 95% confidence interval: 0.426-0.578) with a median survival of 21.4 and 8.1 months, respectively. Superiority of surgical resection was observed in noncirrhotic and cirrhotic subgroups and propensity score matching and inverse probability of treatment weighting adjusted analysis. Asians were more likely to receive surgical resection, whereas Charlson comorbidity ≥3, elevated alpha-fetoprotein, smaller tumor size, care in a community cancer program, and the South or West region were associated with a lower likelihood of surgical resection. Conclusion HCC patients with vascular invasion may benefit from surgical resection compared to systemic therapies. Demographic and clinical features of HCC patients and region and type of treating facility were associated with surgical resection versus systemic treatment.