cssi/SciSciGPT-SciSciNet huggingface dataset:
A comparison of the health of older Hispanics in the United States and Mexico: methodological challenges.

Objectives: This study compares various dimensions of physical and emotional health between older Mexican-origin individuals in the United States and in Mexico. Method: The samples are drawn from the Mexican Health and Aging Study (MHAS) and the Hispanic Established Epidemiologic Study of the Elderly (H-EPESE) and include 3,875 Mexican residents with no history of residence in the United States and 2,734 Mexican-origin individuals 65 and older who live in the southwestern United States. Results: Both immigrant and native-born Mexican-origin elders in the United States report more chronic conditions than elderly Mexicans, but they report fewer symptoms of psychological distress. Longer residence in the United States is associated with higher body mass index scores. Discussion: The discussion addresses the possibility that access to care influences reports of diagnosed conditions and touches on issues of comparability in cross-cultural research and the difficulty in clearly distinguishing cultural and syste...
Modeling of thruster and solar array characteristics in the JPL low-thrust trajectory analysis

Recent advances in thruster and solar array technology have resulted in the possibility of performing many high energy space missions previously considered infeasible. This capability was demonstrated by an extensive study last year of a comet Halley rendezvous mission. In order to perform this extremely high energy mission, several advanced concepts in electric propulsion technology were investigated; notably the use of very high power, lightweight solar arrays which directly powered the beam supply of the electric propulsion thrusters, and the use of solar concentrators on the arrays together with conventional thrusters and power processors. These technology advances have directly impacted the modeling of the solar arrays and thrusters in the programs used in generating low-thrust trajectories. The intent of this paper is to discuss the modeling of the solar arrays and thrusters as employed in the trajectory programs presently being used in low-thrust mission studies at JPL.
Protein Kinase C-β Contributes to Impaired Endothelial Insulin Signaling in Humans With Diabetes Mellitus

Background—Abnormal endothelial function promotes atherosclerotic vascular disease in diabetes. Experimental studies indicate that disruption of endothelial insulin signaling, through the activity of protein kinase C-β (PKCβ) and nuclear factor κB, reduces nitric oxide availability. We sought to establish whether similar mechanisms operate in the endothelium in human diabetes mellitus. Methods and Results—We measured protein expression and insulin response in freshly isolated endothelial cells from patients with type 2 diabetes mellitus (n=40) and nondiabetic controls (n=36). Unexpectedly, we observed 1.7-fold higher basal endothelial nitric oxide synthase (eNOS) phosphorylation at serine 1177 in patients with diabetes mellitus (P=0.007) without a difference in total eNOS expression. Insulin stimulation increased eNOS phosphorylation in nondiabetic subjects but not in diabetic patients (P=0.003), consistent with endothelial insulin resistance. Nitrotyrosine levels were higher in diabetic patients, indicat...
Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel.

Dendrotoxin proteins isolated from Mamba snake venom block potassium channels with a high degree of specificity and selectivity. Using site-directed mutagenesis we have identified residues that constitute the functional interaction surfaces of delta-dendrotoxin and its voltage-gated potassium channel receptor. delta-Dendrotoxin uses a triangular patch formed by seven side-chains (Lys3, Tyr4, Lys6, Leu7, Pro8, Arg10, Lys26) to block K(+) currents carried by a Shaker potassium channel variant. The inhibitory surface of the toxin interacts with channel residues at Shaker positions 423, 425, 427, 431, and 449 near the pore. Amino acid mutations that interact across the toxin-channel interface were identified by mutant cycle analysis. These results constrain the possible orientation of dendrotoxin with respect to the K(+) channel structure. We propose that dendrotoxin binds near the pore entryway but does not act as a physical plug.
Shifting ecological filters mediate postfire expansion of seedling aspen (Populus tremuloides) in Yellowstone

Abstract Determining how ecological filters (e.g., climate, soils, biotic interactions) influence where species succeed in heterogeneous landscapes is challenging for long-lived species (e.g., trees), because filters can vary over space and change slowly through time. Stand-replacing wildfires create opportunities for establishment of tree-species cohorts and can catalyze rapid shifts in where species occur, facilitating unique opportunities for long-term study. We quantified effects of multiple ecological filters on a colonizing cohort of aspen (Populus tremuloides) that established from seed throughout burned lodgepole pine (Pinus contorta var. latifolia) forests after the 1988 fires in Yellowstone National Park (Wyoming, USA) to ask: (1) How have aspen presence, density, and size varied across the postfire landscape, and what filters explain these spatial and temporal patterns? (2) How does aspen above-and belowground biomass vary with postfire lodgepole-pine density? Aspen persisted to postfire year 25 in 58% of the plots in which aspen were present in postfire year 11 (n = 45), and mean stem density declined from 522 to 310 stems ha−1. Mean aspen height doubled (from 29 to 59 cm) over this period. Ecological filters related to climate, competition, herbivory, and soils all differentially affected aspen presence, persistence, and size. Growing season temperature, inter-specific competition, and herbivory also changed through time, altering their effects on the colonizing cohort, and shifting where on the landscape aspen persistence and growth were ultimately favored. Eleven years postfire, aspen were favored at warmer, low elevations; ungulate browsing strongly constrained aspen heights; and competition was unimportant. By 25-years postfire, temperatures warmed nearly 1 °C, and aspen were more likely to persist at cooler, high elevations. Browsing pressure declined, as ungulate populations decreased during this time, but aspen height and basal diameters were constrained by dense, rapidly growing postfire conifers. Landscape mosaics of ecological filters shift over space and time and can facilitate or constrain the persistence and growth of colonizing species. Long-term study of post-disturbance colonizing cohorts uniquely reveal how species are responding to real-time environmental change in heterogeneous landscapes, which will help us better anticipate 21st century species distributions and abundances.
Erratum to 'Gene therapy for neurodegenerative diseases' [Trends in Molecular Medicine 21 (2015) 504-512].

Disclosure: Dr. Boulis is a paid consultant for Agilis, MRI Interventions, Voyager, Oxford Biomedica, Q Therapeutics and Neuralstem Inc. He is a founder of Switch Bio Holdings and was an employee of Above and Beyond LLC up to December 1st, 2015.”We apologize to the readers of this article for the omission of this disclosure.
Nutritional Support of the Geriatric Patient

The past two decades have witnessed a dramatic change in our ability to provide adequate nutrition for our patients. At the present time, this frequently involves the use of enteral tube feedings or intravenous alimentation. This chapter will provide a practical background for the use of these advanced enteral and parenteral nutritional support techniques in the geriatric patient.
Global fund financing to the 34 malaria-eliminating countries under the new funding model 2014–2017: an analysis of national allocations and regional grants

The Global Fund to Fight AIDS, Tuberculosis, and Malaria (GFATM) has been the largest financial supporter of malaria since 2002. In 2011, the GFATM transitioned to a new funding model (NFM), which prioritizes grants to high burden, lower income countries. This shift raises concerns that some low endemic countries, dependent on GFATM financing to achieve their malaria elimination goals, would receive less funding under the NFM. This study aims to understand the projected increase or decrease in national and regional funding from the GFATM’s NFM to the 34 malaria-eliminating countries. Average annual disbursements under the old funding model were compared to average annual national allocations for all eligible 34 malaria-eliminating countries for the period of 2014–2017. Regional grant funding to countries that are due to receive additional support was then included in the comparison and analysed. Estimated funding ranges for the countries under the NFM were calculated using the proposed national allocation plus the possible adjustments and additional funding. Finally, the minimum and maximum funding estimates were compared to average annual disbursements under the old funding model. A cumulative 31 % decrease in national financing from the GFATM is expected for the countries included in this analysis. Regional grants augment funding for almost half of the eliminating countries, and increase the cumulative percent change in GTFAM funding to 32 %, though proposed activities may not be funded directly through national malaria programmes. However, if countries receive the maximum possible funding, 46 % of the countries included in this analysis would receive less than they received under the previous funding model. Many malaria-eliminating countries have projected national declines in funding from the GFATM under the NFM. While regional grants enhance funding for eliminating countries, they may not be able to fill country-level funding gaps for local commodities and implementation. If the GFATM is able to nuance its allocation methodology to mitigate drastic funding declines for malaria investments in low transmission countries, the GFATM can ensure previous investments are not lost. By aligning with WHO’s Global Technical Strategy for Malaria and investing in both high- and low-endemic countries, the Global Fund can tip the scale on a global health threat and contribute toward the goal of eventual malaria eradication.
Primary Tumor Resection and Multimodality Treatment for Patients with Metastatic Colon Cancer

Although controversial, recent data suggest a benefit associated with primary tumor resection (PTR) in metastatic colon cancer (mCC) patients. However, utilization of the various management strategies over time relative to surgery, in particular multimodality treatment (MMT), as well as the impact of age on treatment remains unclear. Historical cohort study of mCC patients in the National Cancer Data Base (1998–2009). Temporal trends in treatment utilization (chemotherapy, PTR alone, MMT) were evaluated. Using a landmark approach, the association between treatment, age, and risk of death was evaluated with multivariable Cox regression, including interaction. Among 103,100 mCC patients, PTR decreased 50.1 % during the study period, whereas MMT and chemotherapy increased 27.4 and 104.8 %, respectively (trend test, p < 0.001). Patients aged ≥75 years were the only group for whom PTR alone was the most common intervention over time and performed more commonly (33.8 %) than MMT (23.8 %) in the most recent study year. Relative to MMT, risk of death was higher for all other management strategies. The sequence of PTR and chemotherapy (reference—surgery first) did not affect risk of death (chemotherapy first—1.05 [0.95–1.15]), as long resection was a part of MMT (PTR alone—1.16 [1.08–1.23]). Patient age did not impact the relative benefit associated with competing management strategies. Although the benefit associated with PTR in mCC patients is a function of MMT, PTR alone remains a common management strategy among older patients. Given the aging U.S. population, exploring provider biases and patient preferences may be necessary to optimize management of mCC patients.
Illinois Lawyer Investigations of Current Client Concerns

When questions are raised by a current client regarding an attorney’s representation of the client, the questioned attorney should be able to seek counsel confidentially. Such a conferral will often benefit the attorney, the firm and the client. Advice regarding questioned conduct should be encouraged, not discouraged. To prompt such conferrals, an attorney-client communication and a work product privilege should be available in Illinois, with availability not dependent upon whether in-house, outside or other attorneys are sought for counsel. While early federal precedents were split, increasingly under other state high court precedents the attorney-client communication privilege is available. Its recognition by the Illinois Appellate Court in 2012 in Garvy should be followed. As well, work product privileges should also be available, though they have not as yet been widely discussed nationally. Yet, because of federal-state and interstate differences in the two privileges, Illinois attorneys and judges must proceed cautiously as not all out-of-state precedents can be followed. The article reviews how Illinois attorneys should best investigate when their legal work is questioned by current clients and how judges should protect such investigations via Illinois’ somewhat unique privilege laws.
Abstract 2563: Identification and functional characterization of a novel UGT2A1 splice variant: Potential importance in tobacco-related cancer susceptibility .

UGT2A1 is a phase II enzyme highly expressed in the respiratory and aerodigestive tracts. In the present study, a novel exon 3 deletion splice variant for UGT2A1 (termed ‘UGT2A1Δexon3’) was characterized. As determined by reverse-transcription polymerase chain reaction, UGT2A1Δexon3 was shown to be co-expressed with wild-type UGT2A1 in various tissues including lung, trachea, larynx, tonsil, and colon. The mRNA expression ratio of UGT2A1Δexon3:wild-type UGT2A1 was highest in colon (0.79±0.08) and lung (0.42±0.12) as determined by real-time PCR; splice variant protein (termed ‘UGT2A1_i2’) to wild-type protein (termed ‘UGT2A1_i1’) ratios were in the range of 0.5-0.9 in these tissues as determined by Western blot analysis using an UGT2A1-specific antibody. In contrast to the UGT2A1 wild-type isoform, homogenates prepared from UGT2A1_i2-over-expressing HEK293 cells exhibited no glucuronidation activity against PAHs, including benzo(a)pyrene-7,8-dihydrodiol (B(a)P-7,8-diol). An inducible in vitro system was created to determine the effect of UGT2A1_i2 expression on UGT2A1_i1 activity. Increasing UGT2A1_i2 levels resulted in a significant (p max against 1-hydroxy (OH)-pyrene, 3-OH-B(a)P and B(a)P-7,8-diol; no significant changes in K M were observed for any of the three substrates. Co-immunoprecipitation experiments suggested the formation of UGT2A1_i1 and UGT2A1_i2 hetero-oligomers and UGT2A1_i1 homo-oligomers; co-expression of UGT2A1_i1 or UGT2A1_i2 with other UGT1A or UGT2B enzymes caused no change in UGT1A or UGT2B glucuronidation activity. These data suggest that a novel UGT2A1 splice variant regulates UGT2A1-mediated glucuronidation activity via UGT2A1-specific protein-protein interactions, and that expression of this variant could play an important role in the detoxification of carcinogens within target tissues for tobacco carcinogenesis. Citation Format: Ryan T. Bushey, Gang Chen, Philip Lazarus. Identification and functional characterization of a novel UGT2A1 splice variant: Potential importance in tobacco-related cancer susceptibility . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2563. doi:10.1158/1538-7445.AM2013-2563
FMRP Mediates Chronic Ethanol-Induced Changes in NMDA, Kv4.2, and KChIP3 Expression in the Hippocampus

Background Exposure to chronic ethanol (EtOH) results in changes in the expression of proteins that regulate neuronal excitability. This study examined whether chronic EtOH alters the hippocampal expression and function of fragile X mental retardation protein (FMRP) and the role of FMRP in the modulation of chronic EtOH-induced changes in the expression of NMDA receptors and Kv4.2 channels. Methods For in vivo studies, C57BL/6J mice underwent a chronic intermittent EtOH (CIE) vapor exposure procedure. After CIE, hippocampal tissue was collected and subjected to immunoblot blot analysis of NMDA receptor subunits (GluN1, GluN2B), Kv4.2, and its accessory protein KChIP3. For in vitro studies, hippocampal slice cultures were exposed to 75 mM EtOH for 8 days. Following EtOH exposure, mRNAs bound to FMRP was measured. In a separate set of studies, cultures were exposed to an inhibitor of S6K1 (PF-4708671 [PF], 6 μM) in order to assess whether EtOH-induced homeostatic changes in protein expression depend upon changes in FMRP activity. Results Immunoblot blot analysis revealed increases in GluN1 and GluN2B but reductions in Kv4.2 and KChIP3. Analysis of mRNAs bound to FMRP revealed a similar bidirectional change observed as reduction of GluN2B and increase in Kv4.2 and KChIP3 mRNA transcripts. Analysis of FMRP further revealed that while chronic EtOH did not alter the expression of FMRP, it significantly increased phosphorylation of FMRP at the S499 residue that is known to critically regulate its activity. Inhibition of S6K1 prevented the chronic EtOH-induced increase in phospho-FMRP and changes in NMDA subunits, Kv4.2, and KChIP3. In contrast, PF had no effect in the absence of alcohol, indicating it was specific for the chronic EtOH-induced changes. Conclusions These findings demonstrate that chronic EtOH exposure enhances translational control of plasticity-related proteins by FMRP, and that S6K1 and FMRP activities are required for expression of chronic EtOH-induced homeostatic plasticity at glutamatergic synapses in the hippocampus.
Geochemical analysis of volcanic rocks of the third part of Yingcheng Formation in Anda sag

According to geochemical data of volcanic rocks of seven wells of the third part of Yingcheng Formation in Anda sag on the volcanic lithology to be divided,and further divided into a series of volcanic rocks named classified,and finally the formation of volcanic rocks in the area to conduct a brief summary of the environment.
Gynecologic Neoplasms: Cervical, Ovarian, Vulvar, Uterine, and Endometrial Cancer

This chapter illustrates clinical case examples demonstrating clinical utility and diagnostic performance of FDG PET-CT scans in gynecologic neoplasms which includes, cervical, ovarian, vulvar, uterine, and endometrial cancers.
Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery

ABSTRACTIntroduction: Androgen receptor (AR) is a ligand-dependent transcription factor and a member of the nuclear receptor superfamily. It plays a vital role in male sexual development and regulates gene expression in various tissues, including prostate. Androgens are compounds that exert their biological effects via interaction with AR. Binding of androgens to AR initiates conformational changes in AR that affect binding of co-regulator proteins and DNA. AR agonists and antagonists are widely used in a variety of clinical applications (i.e. hypogonadism and prostate cancer therapy).Areas covered: This review provides a close look at structures of AR-ligand complexes and mutations in the receptor that have been revealed, discusses current challenges in the field, and sheds light on future directions.Expert opinion: AR is one of the primary targets for the treatment of prostate cancer, as AR antagonists inhibit prostate cancer growth. However, these drugs are not effective for long-term treatment and lea...
ISLET CELL ADENOMA IN CHILDHOOD: REPORT OF A CASE

The case of an 11-year-old boy with multiple islet cell adenoma of the pancreas is described. The case is of particular interest because the mild and infrequent symptoms resulted in an incorrect diagnosis of a primary convulsive disorder. The problems of accurate pre-operative diagnosis, despite the availability of all current diagnostic studies, are emphasized. The absence of abnormal elevations in serum insulin, as observed in this patient, cannot be used to exclude the possibility of islet cell adenoma. Review of the literature as well as the experience of The Johns Hopkins Hospital underlines the importance of islet cell adenoma as a primary cause for hypoglycemia in the older child. Absence of severe hypoglycemia must not dissuade the physician from complete evaluation of such patients.
Production of lipids from microalgae Spirulina sp.: influence of drying, cell disruption and extraction methods.

Abstract The pretreatment operations (drying, cell disruption and oil extraction) of microalgae biomass to the lipids extraction are important steps to the product quality and production cost. In this study, the lipids from Spirulina were obtained by different methods of biomass drying (tray and spouted bed), cell disruption (microwave, autoclaving and milling) and solvent extraction (hot and cold). The average content of lipids extracted by the cold method, using polar solvents, was of 5.8 ± 0.6 g 100 g−1. The spouted bed drying with cell disruption by milling achieved the best performance with the hot extraction method. Under these conditions, the TBA value was of 0.57 ± 0.09 mgMDA kg−1. FT-IR spectra and thermal analysis indicated that the hot extraction resulted in a more purified lipid extract than the cold extraction. The Brimberg model showed the best fit to the lipid extraction kinetics and the activation energy in the best conditions was of 6.11 ± 1.41 kJ mol−1.
From Bench to Bedside and Back Again: A Personal Journey with Dexmedetomidine

Dexmedetomidine Diminishes Halothane Anesthetic Requirements in Rats Through a Postsynaptic Alpha 2 Adrenergic Receptor. By Segal IS, Vickery RG, Walton JK, Doze VA, and Maze M. ANESTHESIOLOGY 1988; 125:590-4. Abstract reprinted with permission.The effect of 4(5)-[1-(2,3-dimethylphenyl)ethyl]imidazole (medetomidine), the α2 adrenergic agonist, on anesthetic requirements was investigated in rats anesthetized with halothane. Halothane MAC was determined before and after either dexmedetomidine (D-enantiomer) or levomedetomidine (L-enantiomer) 10, 30, and 100 μg/kg, or vehicle intraperitoneally. There was a dose-dependent increase in MAC with the D-, but not the L-, stereoisomer. At the highest dose of dexmedetomidine (100 μg/kg), halothane could be discontinued for up to 30 min with no response to tail clamping. To determine whether α2 adrenoreceptors mediated this effect of dexmedetomidine on MAC, cohorts of rats were pretreated with idazoxan, 10 mg/kg intraperitoneally, a highly selective α2 antagonist. This completely prevented the reduction of MAC caused by dexmedetomidine. To determine whether the reduction of MAC caused by dexmedetomidine was mediated in part through either opiate or adenosine receptors, groups of rats were pretreated with either naltrexone, 5 mg/kg intraperitoneally, an opiate antagonist, or 8-phenyltheophylline, 2.5 mg/kg intraperitoneally, an A1 adenosine antagonist. These two pretreatments did not alter the reduction of MAC by dexmedetomidine. To determine whether postsynaptic mechanisms mediate the anesthetic effect of dexmedetomidine, rats were depleted of central catecholamine stores with either n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine or reserpine and α-methyl-para-tyrosine, and MAC was determined before and after each dose of dexmedetomidine. While the catecholamine-depleted rats had a lower basal MAC than the vehicle controls, there was still a profound reduction in halothane MAC after administration of dexmedetomidine. The reduction of MAC by dexmedetomidine was blocked with idazoxan in the catecholamine-depleted rats. These data indicate that the reduction of MAC caused by dexmedetomidine is mediated through α2 adrenoreceptors with no apparent involvement of either opiate or A1 adenosine receptors. Data from catecholamine-depleted rats suggest that the mediating mechanism must involve site(s) other than or in addition to the presynaptic α2 adrenergic receptors on noradrenergic neurons. The authors conclude that central postsynaptic α2 adrenergic receptors mediate a significant part of the reduction of anesthetic requirements caused by dexmedetomidine.
Handshaking in kansas lava using patch logic

Designing hardware is like writing music for an orchestra - lots of pieces have to come together at the correct time for everything to work. In systems design, there is a confusing array of standards for allowing cooperating components, and little type-level support in traditional design methodologies for helping connect components with pre-arranged protocols. In this paper, we explore bringing protocol-level types to communicating processes. Inside our hardware description language Kansas Lava we introduce the notation of a patch, which is a communicating component with well-understood protocols. We build a theory round the notion of patches, which we call patch logic, and then use the patch abstraction to build a small driver for an FPGA board.
Nanoparticles for PET Imaging of Tumors and Cancer Metastasis

Positron emission tomography (PET) is a highly translational imaging modality with high sensitivity for oncological imaging. A wide range of classes of nanoparticles have been radiolabeled with a variety of positron-emitting radionuclides; however, the vast majority of nanoparticles have been labeled with longer-lived Cu-64 (T1/2 = 12.7 h) and Zr-89 (T1/2 = 78.4 h), due to their relatively slow clearance from the blood into tumors. PET imaging with nanoparticles has been investigated with agents that passively accumulate in tumors via the enhanced permeation and retention (EPR) effect, and nanoparticles have also been conjugated to targeting agents that include peptides and antibodies (or fragmented constructs thereof) for more active receptor-based tumor targeting. This chapter provides an overview of nanoparticle-based PET agents that have been developed for tumor targeting.
Exile to Poverty: Policies and Poverty Among Refugees in Poland

Poverty is a well-known short-term outcome of migration in general and a long-term outcome of forced migration in a global context. Surprisingly, this outcome appears among refugees in welfare states which provide various asylum and social policies facilitating integration. The article aims to explore the relationship between asylum and social policies and poverty among refugees. The research results are drawn from two studies conducted among refugees, NGOs, national and local administration representatives, and case workers in Poland between 2006 and 2014. The results show that asylum policy contributes to the material and symbolic hardship experienced by refugees, and social policy is ineffective in its prevention. If refugees are settled in regions with high levels of poverty, unemployment and ethnic-based prejudices, then they experience and continue to live in poverty. In such a context, and due to its weaknesses in addressing discrimination, social policy cannot successfully integrate refugees.
Evaluation of Published Delayed-Neutron Parameters for Uranium-235 and Uranium-235 Heavy Water Systems

(1971). Evaluation of Published Delayed-Neutron Parameters for Uranium-235 and Uranium-235 Heavy Water Systems. Nuclear Science and Engineering: Vol. 43, No. 2, pp. 229-233.
Using Spatial and Temporal Mapping to Identify Nosocomial Disease Transmission of Clostridium difficile.

This study evaluates the use of spatial and temporal mapping to identify nosocomial disease transmission of Clostridium difficile.
Efficient Discovery of Abnormal Event Sequences in Enterprise Security Systems

Intrusion detection system (IDS) is an important part of enterprise security system architecture. In particular, anomaly-based IDS has been widely applied to detect single abnormal process events that deviate from the majority. However, intrusion activity usually consists of a series of low-level heterogeneous events. The gap between low-level process events and high-level intrusion activities makes it particularly challenging to identify process events that are truly involved in a real malicious activity, and especially considering the massive 'noisy' events filling the event sequences. Hence, the existing work that focus on detecting single events can hardly achieve high detection accuracy. In this work, we formulate a novel problem in intrusion detection - suspicious event sequence discovery, and propose GID, an efficient graph-based intrusion detection technique that can identify abnormal event sequences from massive heterogeneous process traces with high accuracy. We fully implement GID and deploy it into a real-world enterprise security system, and it greatly helps detect the advanced threats and optimize the incident response. Executing GID on both static and streaming data shows that GID is efficient (processes about 2 million records per minute) and accurate for intrusion detection.
A Sub-millimeter, Inductively Powered Neural Stimulator

Wireless neural stimulators are being developed to address problems associated with traditional lead-based implants. However, designing wireless stimulators on the sub-millimeter scale (<1mm3) is challenging. As device size shrinks, it becomes difficult to deliver sufficient wireless power to operate the device. Here, we present a sub-millimeter, inductively powered neural stimulator consisting only of a coil to receive power, a capacitor to tune the resonant frequency of the receiver, and a diode to rectify the radio-frequency signal to produce neural excitation. By replacing any complex receiver circuitry with a simple rectifier, we have reduced the required voltage levels that are needed to operate the device from – 0.5 - 1V (e.g. for CMOS) to approximately 0.25 – 0.5V. This reduced voltage allows the use of smaller receive antennas for power, resulting in a device volume of 0.3 – 0.5mm3. The device was encapsulated in epoxy, and successfully passed accelerated lifetime tests in 80°C saline for two weeks. We demonstrate a basic proof-of-concept using stimulation with tens of microamps of current delivered to the sciatic nerve in rat to produce a motor response. The device is designed to operate in tissue up to approximately 5cm depth.
Historical Slavery and Modern-Day Stroke Mortality in the United States Stroke Belt

In the United States, stroke incidence and related mortality have declined in the past half century.1,2 This drop is largely because of better recognition and control of modifiable cardiovascular disease risk factors.3,4 There remain significant racial disparities however, and studies and surveillance programs consistently show higher rates of stroke and stroke-related mortality in native born blacks when compared with non-Hispanic whites (NHW).5–9 Nowhere is this racial disparity more evident than in the stroke belt, an area in the Southeastern United States with disproportionately high rates of stroke.10–12 Although a higher prevalence of cardiovascular disease risk factors, specifically hypertension, diabetes mellitus, obesity, and cigarette smoking, account for much of the excess stroke risk, it remains unclear why these cardiovascular comorbidities, and other lifestyle-related risk factors, cluster in this region of the United States, particularly in blacks.13–15 Multiple explanations have been proposed, but the medical community has yet to offer a fully satisfactory explanation for what is driving stroke mortality in the ≈700 hot spot counties of the stroke belt.16 A clue is that these counties also have higher proportions of black residents and unemployment, as well as lower educational status, median income, and healthcare use.16 While often ignored in the medical literature, a history of slavery, and ongoing social segregation, racial discrimination, and economic inequality, provide a historical precedent for the phenotype of poor cardiovascular health observed in several predominantly black communities. Although many reports depict the racial disparities and skew in stroke risk factors in this region of the United States, a PubMed search using the words slavery, slave, stroke, stroke belt, and cardiovascular disease returned no relevant articles. Our goal is to review the historical evidence and test the strength of association …
Compatibility of Type-304 Stainless Steel with Sodium Paste Reactor Fuels

(1967). Compatibility of Type-304 Stainless Steel with Sodium Paste Reactor Fuels. Nuclear Science and Engineering: Vol. 30, No. 2, pp. 310-311.
School-based suicide prevention: content, process, and the role of trusted adults and peers.

Suicide is a leading cause of preventable death in youth, and numerous curricula and other prevention and intervention programs have been developed in the last 15 years. Comprehensive suicide prevention planning should include the 4 components of health promotion, prevention/education, intervention, and postvention. School-based suicide prevention and mental health education programs have become more common as an efficient and cost-effective way to reach youth. Process considerations that are based on the principles of therapeutic engagement with patients and families can provide mental health professionals with strategies that can assist education professionals, students, and the larger school community simultaneously. Language: en
Path Integral for the Harmonic Oscillator

So far we have computed path integrals for potentials V which are linear in the variable x: V(x) = cx for some constant c. Consider now a quadratic potential: V(x) = cx2. Specifically, consider V(x) =&#03C9; 2 mx 2/2 where m is the mass of a simple harmonic oscillator with frequency v = ω/2π. As discussed in Chapter 2 the equation of motion is $$x(t) = A\cos (\omega t - \delta ) = A\sin (\omega t + \Phi ),$$ (1)
In Silico and Experimental Evaluation of Primer Sets for Species-Level Resolution of the Vaginal Microbiota Using 16S Ribosomal RNA Gene Sequencing.

Background Identification of bacteria in human vaginal specimens is commonly performed using 16S ribosomal RNA (rRNA) gene sequences. However, studies utilize different 16S primer sets, sequence databases, and parameters for sample and database clustering. Our goal was to assess the ability of these methods to detect common species of vaginal bacteria. Methods We performed an in silico analysis of 16S rRNA gene primer sets, targeting different hypervariable regions. Using vaginal samples from women with bacterial vaginosis, we sequenced 16S genes using the V1-V3, V3-V4, and V4 primer sets. For analysis, we used an extended Greengenes database including 16S gene sequences from vaginal bacteria not already present. We compared results with those obtained using the SILVA 16S database. Using multiple database and sample clustering parameters, each primer set's ability to detect common vaginal bacteria at the species level was determined. We also compared these methods to the use of DADA2 for denoising and clustering of sequence reads. Results V4 sequence reads clustered at 99% identity and using the 99% clustered, extended Greengenes database provided optimal species-level identification of vaginal bacteria. Conclusions This study is a first step toward standardizing methods for 16S rRNA gene sequencing and bioinformatics analysis of vaginal microbiome data.
Diagnostic value of MR-based texture analysis for the assessment of hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).

To investigate the performance of MR-based texture analysis (TA) for the assessment of hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Fifty-four adult patients (33 females, 21 males, mean age 49.8 ± 13.5 years) with biopsy-proven NAFLD were enrolled and underwent MR imaging on a 1.5 T system. TA parameters were extracted on axial noncontrast 3D-GRE T1W images (slice thickness = 4.6 mm) using a commercially available research software (TexRAD). Receiver operating curves (ROC), areas under the ROC (AUROC) and 95% confidence intervals (CI) were calculated to assess the accuracy of each TA parameter for the diagnosis of significant (F ≥ 2) and advanced fibrosis (F ≥ 3). The correlation between TA and histopathological features of nonalcoholic steatohepatitis (NASH) was tested calculating the Spearman’s rank correlation coefficient (ρ). Thirty-seven (68%) subjects had significant fibrosis and 20 (37%) had advanced fibrosis. The TA parameters with the best performance were standard deviation (SD) and entropy, respectively, with AUROC 0.755 (95% CI 0.619–0.862, p ≤ 0.0002) and 0.769 (95% CI 0.634–0.873, p < 0.0001) for significant fibrosis and AUROC 0.746 (95% CI 0.609–0.854, p ≤ 0.0004) and 0.754 (95% CI 0.618–0.861, p ≤ 0.0002) for advanced fibrosis. SD and entropy demonstrated a moderate correlation with the degree of fibrosis (ρ = 0.457 and 0.480; p < 0.01). No significant correlation was found between TA parameters and other histopathological features of NASH. Entropy and SD extracted on T1-weighted MR images have fair accuracy for the diagnosis of significant and advanced hepatic fibrosis in patients with NAFLD.
Automatically Generating Interesting Facts from Wikipedia Tables

Modern search engines provide contextual information surrounding query entities beyond ten blue links in the form of information cards. Among the various attributes displayed about entities there has been recent interest in providing fun facts. Obtaining such trivia at a large scale is, however, non-trivial: hiring professional content creators is expensive and extracting statements from the Web is prone to uninteresting, out-of-context and/or unreliable facts. In this paper we show how fun facts can be mined from superlative tables in Wikipedia, whose rows are ranked according to some statistics, to provide a large volume of reliable and interesting content. We employ a template-based approach to semi-automatically generate natural language statements as fun facts. We show how to bootstrap and streamline the process for faster and cheaper task completion. However, the content contained in these tables is dynamic. Therefore, we address the problem of automatically maintaining the pairing of templates to tables as the tables are updated over time. Fun facts produced by our work is now part of Google's production search results.
Copper ion vs copper metal-organic framework catalyzed NO release from bioavailable S-Nitrosoglutathione en route to biomedical applications: Direct 1H NMR monitoring in water allowing identification of the distinct, true reaction stoichiometries and thiol dependencies.

Abstract Copper containing compounds catalyze decomposition of S -Nitrosoglutathione (GSNO) in the presence of glutathione (GSH) yielding glutathione disulfide (GSSG) and nitric oxide (NO). Extended NO generation from an endogenous source is medically desirable to achieve vasodilation, reduction in biofilms on medical devices, and antibacterial activity. Homogeneous and heterogeneous copper species catalyze release of NO from endogenous GSNO. One heterogeneous catalyst used for GSNO decomposition in blood plasma is the metal-organic framework (MOF), H 3 [(Cu 4 Cl) 3 -(BTTri) 8 , H 3 BTTri = 1,3,5-tris( 1 H-1,2,3-triazol-5-yl) benzene] (CuBTTri). Fundamental questions about these systems remain unanswered, despite their use in biomedical applications, in part because no method previously existed for simultaneous tracking of [GSNO], [GSH], and [GSSG] in water. Tracking these reactions in water is a necessary step towards study in biological media (blood is approximately 80% water) where NO release systems must operate. Even the balanced stoichiometry remains unknown for copper-ion and CuBTTri catalyzed GSNO decomposition. Herein, we report a direct 1 H NMR method which: simultaneously monitors [GSNO], [GSH], and [GSSG] in water; provides the experimentally determined stoichiometry for copper-ion vs CuBTTri catalyzed GSNO decomposition; reveals that the CuBTTri-catalyzed reaction reaches 10% GSNO decomposition (16 h) without added GSH, yet the copper-ion catalyzed reaction reaches 100% GSNO decomposition (16 h) without added GSH; and shows 100% GSNO decomposition upon addition of stoichiometric GSH to the CuBTTri catalyzed reaction. These observations provide evidence that copper-ion and CuBTTri catalyzed GSNO decomposition in water operate through different reaction mechanisms, the details of which can now be probed by 1 H NMR kinetics and other needed studies.
Photostable Voltage-Sensitive Dyes Based on Simple, Solvatofluorochromic, Asymmetric Thiazolothiazoles

A family of asymmetric thiazolo[5,4-d]thiazole (TTz) fluorescent dye sensors has been developed, and their photophysical sensing properties are reported. The π-conjugated, TTz-bridged compounds are synthesized via a single-step, double condensation/oxidation of dithiooxamide and two different aromatic aldehydes: one with strong electron-donating characteristics and one with strong electron-accepting characteristics. The four reported dyes include electron-donating moieties (N,N-dibutylaniline and N,N-diphenylaniline) matched with three different electron-accepting moieties (pyridine, benzoic acid, and carboxaldehyde). The asymmetric TTz derivatives exhibit strong solvatofluorochromism with Stokes shifts between 0.269 and 0.750 eV (2270 and 6050 cm-1) and transition dipole moments (Δμ = 13-18 D) that are among the highest reported for push-pull dyes. Fluorescence quantum yields are as high as 0.93 in nonpolar solvents, and the fluorescence lifetimes (τF) vary from 1.50 to 3.01 ns depending on the solvent polarity. In addition, thermofluorochromic studies and spectrophotometric acid titrations were performed and indicate the possibility of using these dyes as temperature and/or acid sensors. In vitro cell studies indicate good cell membrane localization, negligible cytotoxicity, promising voltage sensitivities, and photostabilities that are 4 times higher than comparable dyes. Their ease of synthesis and purification, remarkable photophysical properties, and chemically sensitive TTz π-bridge make these asymmetric dye derivatives attractive for environmental and biological sensing or similar molecular optoelectronic applications.
Medical Malpractice Claims in Mississippi: A Preliminary Analysis

This essay explains where medical malpractice claims are filed in Mississippi. It initially does so by collecting state circuit court data, which have been recently released by the Administrative Office of Courts. The essay, then, computes summary statistics. Lastly, it examines these statistics: in order to find out which county had the most medical malpractice claims.
Case report of a girl with rare ovarian steroid cell tumor

对郑州儿童医院内分泌遗传代谢科收治的1例女童卵巢类固醇细胞瘤患儿的临床资料行回顾性分析。患儿，女，7岁，其临床特点为女童异性性早熟。查体：男性化体征。雄烯二酮、睾酮、17a-羟基孕酮明显高于正常，骨龄超前，盆腔磁共振成像示卵巢来源肿瘤可能性大，病理检查提示右侧卵巢类固醇细胞肿瘤。予右侧卵巢肿瘤切除术。现随访3个月血清雄激素正常，男性化体征无进展。提示女童异性性早熟，要考虑卵巢类固醇细胞瘤可能，手术是最重要的治疗手段，激素水平及影像学检查对诊断、病情监测、疗效评估有重要价值。对该疾病要重视后期随访。
Minority Student Preparation for STEM PhD Study: Impact of NSF Bridge to the Doctorate Programming

The Texas A&M University System (TAMUS) received funding from the National Science Foundation (NSF) for a Louis Stokes Alliance for Minority Participation (LSAMP) project in 1991 as one of the six initial awardees. As part of these efforts and upon reaching eligibility, the TAMUS LSAMP applied for and received additional funding to support a Bridge to the Doctorate (BTD) program. BTD programming provides financial, educational, and social support to incoming STEM master’s degree and PhD students for the first two years of their graduate study. BTD cohorts consist of up to 12 fellows who participate in a program of academic and professional development seminars and workshops. In project evaluation, annual interviews were conducted with the TAMUS BTD participants, the vast majority of whom were underrepresented minorities (92%). During the interviews, the BTD students were asked to discuss ten topics some of which addressed concerns specific to the implementation of the BTD project. This report considers answers provided in the five topic areas which have broader applicability: 1) the learning achieved by participants through participation in BTD, 2) the personal impact of participation in BTD, 3) the influence of BTD on informants’ educational goals, 4) the influence of BTD on informants’ career goals, and 5) barriers the BTD participants perceived to pursuing a PhD. Eighty project participants responded to the questions between 2009 and 2018. They were from eight distinct cohorts of BTD students and represented 32 different areas of STEM specialization. Qualitative analysis of their responses confirmed that students perceived the elements of the TAMUS BTD project to be efficacious and that there was a set of nine seminars from which participants consistently reported benefit. Additional findings were eight key areas in which learning was reported by participants, four areas in which the programming had personal impact, five influences on educational goals, nine impacts on career goals, and a detailed list of barriers graduate students who are underrepresented minorities (URM) perceive to pursuing a doctoral degree. The proven and easily replicated pattern of support programming, the demonstrated results of this programming, and insight into barriers URMs perceive to pursuing a STEM doctorate are immediately applicable to URM graduate student support at many institutions of higher education.
Assessing Preble’s Meadow Jumping Mouse (Zapus hudsonius preblei) Habitat and Connectivity for Conservation and Restoration

The federally-threatened Preble’s meadow jumping mouse (Zapus hudsonius preblei) occurs in riparian zones located along the foothills and plains in the Front Range of Colorado and Wyoming. Anthropogenic and natural disturbances have extensively modified Front Range riparian ecosystems affecting the location, quality, and connectivity of Z. h. preblei populations and habitat. Previous studies suggest that specific microhabitat conditions influence Z. h. preblei occurrence but no landscape-scale assessments have been conducted. To support conservation and management, we assessed Z. h. preblei habitat in Boulder County, Colorado by mapping riparian land cover composition, creating species distribution models (SDM), and evaluating connectivity between suitable habitat and known Z. h. preblei populations. The SDM identified 5381 ha of suitable Z. h. preblei habitat, compared with 252 ha of known Z. h. preblei occupied habitat. We found limited connections between Z. h. preblei populations in different watersheds, as urban development and large expanses of agricultural land disrupt connectivity. Our modeling approach yielded outcomes that are broadly relevant to understanding the distribution and management of geographically restricted species impacted by habitat loss and has provided insight into Z. h. preblei habitat and connectivity that cannot be gathered from field work alone.
It is time for more critical CS education

By which 'critical' means an intellectual stance of skepticism, centering the consequences, limitations, and unjust impacts of computing in society.