cssi/SciSciGPT-SciSciNet huggingface dataset:
Sleep habits in children with attention-deficit/hyperactivity disorder predominantly inattentive type and associations with comorbid psychopathology symptoms

Abstract Objectives Much of what is currently known about the sleep functioning of children with attention-deficit/hyperactivity disorder (ADHD) is based on samples of children with ADHD combined type, and no study to date has examined the association between sluggish cognitive tempo (SCT) and sleep functioning in children diagnosed with ADHD. Accordingly, the objectives of this study were to (1) describe the sleep habits of children diagnosed with ADHD predominantly inattentive type (ADHD-I) and (2) examine whether comorbid internalizing, oppositional, and/or SCT symptoms are associated with poorer sleep functioning in children with ADHD-I. This study extends the current literature by using a large, clinical sample of children with ADHD-I to examine the association between SCT and other psychopathology symptoms with children's sleep functioning. Methods Participants included 147 children (age: 6–11, 59% male, 55% White) diagnosed with ADHD-I using a semi-structured diagnostic interview. Parents completed measures assessing their child's sleep habits as well as comorbid anxiety, depression, oppositionality, and SCT symptoms. Results Fourteen percent of children with ADHD-I obtain less sleep than recommended and 31% have a sleep onset latency of greater than 20 minutes. The few children taking medication for ADHD had a longer sleep onset latency than those without medication. Twenty-seven percent of parents indicated that it is "difficult" to get their child out of bed on school days and 41% of parents indicated that their child needs to catch-up on sleep on the weekend "at least a little". Regression analyses found anxiety and SCT sleepy/tired symptoms to be the most consistent dimensions of psychopathology associated with sleep functioning, with little support for depression or oppositionality being associated with sleep. Conclusions A sizeable minority of children with ADHD-I experience impaired sleep. In addition to SCT sleepy/tired symptoms, comorbid anxiety was most consistently associated with poorer sleep functioning in children with ADHD-I. SCT daydreaming and working memory symptoms were unassociated with sleep functioning, and the size of the effects between SCT sleepy/tired and sleep functioning indicates that these are not overlapping constructs. Longitudinal studies are needed to evaluate the interrelations of sleep problems and comorbid psychopathology symptoms and their impact on the daytime functioning of children with ADHD-I.
Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factor and/or interleukin-3

We have studied the effects of recombinant human thrombopoietin (TPO; mpl ligand) on the proliferation of human primitive hematopoietic progenitors in vitro. CD34+ cells were enriched for cell-cycle-dormant primitive progenitors by separation on the basis of expression of c-kit and CD38. In the presence of varying combinations of TPO, Steel factor (SF), and interleukin-3 (IL-3), CD34+/c-kit(low)/CD38neg/low cells produced fewer colonies than CD34+/c-kit(low)/CD38high cells. However, when cultured in suspension for 7 days and replated in methylcellulose culture for measurement of colony-forming cells, the former population generated more colony-forming cells than the latter. In suspension culture of CD34+/c-kit(low)/CD38neg/low cells, TPO acted synergistically with SF and/or IL-3 in support of the production of colony-forming cells for granulocyte/macrophage colonies, erythroid colonies, and mixed colonies. Culture studies of individual CD34+/c- kit(low)/CD38neg/low cells provided the evidence for the direct nature of the effects of TPO. When combined with SF, TPO showed stronger stimulation of production of progenitors in suspension culture than other early-acting factors, such as IL-6, IL-11, and granulocyte colony- stimulating factor (G-CSF). TPO may be an important cytokine for in vitro manipulation of human hematopoietic stem cells.
Abstract 87: The Accumulation of Myeloid-derived Suppressor Cells Is a Compensatory Response to the Development of Hypertension

The immune system plays a critical role in the development of hypertension. The immune response consists of pro-inflammatory cells, but also immunosuppressive cells that reduce T cell function. An ...
Abstract 2500: Left Ventricular Recovery in Peripartum Cardiomyopathy: Impact of Beta Blockade

Introduction : Peripartum cardiomyopathy (PPCM) remains a major cause of maternal morbidity and mortality. PPCM is associated with acute myocardial dysfunction with a high rate of spontaneous recovery. For subjects with chronic non-ischemic cardiomyopathy, beta blockade (BB) increases left ventricular ejection fraction (LVEF), reverses remodeling and improves survival. The impact of beta blockade (BB) on recovery in acute inflammatory cardiomyopathy is less certain. We investigated the impact of BB on left ventricular recovery in a single center series of women with PPCM. Method: Thirty-six subjects with PPCM referred within the first six months post partum from 1994 to 2006 to the University of Pittsburgh Heart Failure Program were retrospectively reviewed. LVEF and LV diastolic diameter (LVEDD) were assessed by echocardiography at the time of referral (entry) and at approximately 6 and 12 months post partum. Medical therapy was assessed and LV recovery compared by treatment subset. Results: The mean age was 29.7 ± 6.9 years, gravida 2.9 ± 1.9, and para 2.3 ± 0.9. LVEF at presentation was 0.23 ± 0.09. Therapy at entry included ACE inhibitors in 95% of subjects Overall 19 (53%) subjects were not on BB at entry (Group A) while 17 were treated with BB (Group B). BB use differed based on year of presentation with 12% prior to January of 2000 and 80% post on BB therapy. Significant recovery was evident by 12 months by LVEF(0.23 ± 0.09 to 0.41 ± 0.16, p = 0.03)and LVEDD( 5.8 ± 0.9 to 5.3 ± 0.9, p = 0.01). Of note, recovery did not differ significantly by year of presentation or BB therapy(table). Conclusion : Similar recovery was evident in subjects with PPCM treated with BB and recent historical controls not on therapy. While BB clearly plays an important role in treatment of women with chronic PPCM, they do not appear to enhance the probablity of spontaneous resolution.
Intraabdominal vancomycin-resistant enterococcus infections: the new threat.

Goals: To determine the clinical course and outcome in patients with intraabdominal vancomycin-resistant enterococcus infections (VRE-A) and to identify probable risk factors for VRE-A. Background: Vancomycin-resistant enterococcus is one of the most notable nosocomial emerging pathogens. The incidence is increasing, especially in the abdominal surgery setting. Study: A comparative study of patients with VRE-A and VRE infection in other sites (VRE-O) who were hospitalized for over 1 year. Fisher exact test and Student t test were used; a two-tailed p value of less than 0.05 was considered to be significant, Results: Of 89 nine patients with VRE, six had VRE-A, 24 had VRE-O, and 59 had VRE colonization. The VRE-A group was comprised of one patient with an inoperable Klatskin tumor and biliary sepsis, one with acquired immune deficiency syndrome and an infected pancreatic pseudocyst, two with fecal peritonitis, and two with biliary sepsis after surgery for common bile duct stones. All six patients with VRE-A had recent surgery before VRE isolation, as compared with three in the VRE-O group (p = 0.0001). Despite adequate treatment with intravenous chloramphenicol, resulting in eradication of VRE in all six VRE-A cases, the mortality rate remained high at 50%. Conclusions: Vancomycin-resistant enterococcus should be recognized as an emerging nosocomial pathogen that causes potentially fatal intraabdominal infections in the postsurgical setting. However, the impact of treatment on ultimate outcome needs further evaluation.
New Implicit Solvation Scheme for Solid Surfaces

It is shown that the effect of water on the bonding characteristics of transition metal surfaces with adsorbates is short-ranged. As a result, adsorption energies in water can be evaluated by a combination of plane-wave density functional theory calculations in vacuum and properly chosen cluster model calculations with and without an implicit solvation model. The scheme is demonstrated for a model C–C cleavage reaction on Pt (111) and for predicting CO frequency shifts on Pd and Pt due to water. We conclude that these shifts originate from water–metal interactions and can be explained by changes in π back-donation. Overall, the results demonstrate that the proposed methodology represents a highly efficient computational approach for approximating the effect of solvents on elementary reaction steps occurring at solid–liquid interfaces of heterogeneous catalysts.
The Procedural Impact of an Environmental Impact Statement on Judicial Review

On a sunny summer day in 2014, Drakes Bay Oyster Company closed its doors to the public, admitting defeat in a years-long fight with the Department of the Interior over the renewal of its operating permit. The Secretary of the Interior believed that the region’s designation as “potential wilderness” under the Point Reyes Wilderness Act, along with public policy considerations, obligated him to decline renewal of the permit. In producing an Environmental Impact Statement regarding the impact of closing the farm, the Secretary procedurally insulated his agency decision from later judicial review in Drakes Bay Oyster
SURVEY ON MENSTRUATION REACTION AND EMOTIONAL HEALTH OF ADOLESCENT SCHOOL GIRLS

[Objective]To investigate whether all physical and psychological symptoms are specific in menstruation.To study whether physiological development and emotional health of adolescent school girls is related.[Methods]We made retrospective menstruation investigation on 862 school girls by questionnaires,with an investigation on their emotional health behavior.[Results]In all symptoms,the incidence rates of abdominal pain,sore waist and inferior belly expand were highest.They respectively were 50.72%,23.44% and 23.13%.However,there was no difference in the incidence rates of psychological behavior symptoms.We found menstruation reaction were direct correlate with nine SCL-90 factor,especially human being,anxietas,depress,constraint and dread and so on.[Conclusion]We should pay close attention to various kinds psychological,behaviour and emotional problems of adolescent school girls and the cultivation of their good personality.Thereby their physiology and psychology can develop well.
Measurement of Ca(2+)-ATPase activity (in PMCA and SERCA1).

Ca(2+)-ATP pumps (those on the plasma membrane; PMCA and sarcoplasmic reticulum; SERCA1) have an important role to play in the regulation of intracellular calcium concentrations. In this chapter, three preparations, two membranes and a purified enzyme, best suited for studies of Ca(2+)-ATPase activity are described. The two selected membranes are the human red blood cell (RBC) ghosts, a representative of plasma membranes (PM), and the rabbit skeletal muscle SR, an intracellular membrane. In this protocol, Pi released during the ATPase reaction is subsequently measured colorimetrically as a complex of molybdovanadate. The method is simple (one-step), fast, sensitive, and reliable.
Intracellular pH regulation in IEC-6 cells, a cryptlike intestinal cell line.

Regulation of intracellular pH, pHi, was studied using microspectrofluorimetry of the pH-sensitive, fluorescent dye 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein in the rat intestinal crypt cell ...
A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis

The rate of receptor-mediated endocytosis of diferric 125I-transferrin by Chinese-hamster ovary cells expressing human transferrin receptors was compared with the rate measured for cells expressing hamster transferrin receptors. It was observed that the rate of endocytosis of the human transferrin receptor was significantly higher than that for the hamster receptor. In order to examine the molecular basis for the difference between the observed rates of endocytosis, a cDNA clone corresponding to the cytoplasmic domain of the hamster receptor was isolated. The predicted primary sequence of the cytoplasmic domain of the hamster transferrin receptor is identical with that of the human receptor, except at position 20, where a tyrosine residue in the human sequence is replaced with a cysteine residue. To test the hypothesis that this structural change in the receptor is related to the difference in the rate of internalization, we used site-directed mutagenesis to examine the effect of the replacement of tyrosine-20 with a cysteine residue in the human transferrin receptor. It was observed that the substitution of tyrosine-20 with cysteine caused a 60% inhibition of the rate of iron accumulation by cells incubated with [59Fe]diferric transferrin. No significant difference between the rate of internalization of the mutant (cysteine-20) human receptor and the hamster receptor was observed. Thus the substitution of tyrosine-20 with a cysteine residue can account for the difference between the rate of endocytosis of the human and hamster transferrin receptors.
Freezing and Frozen-Food Storage

Food freezing is the preservation process that depends on the reduction of product temperature to levels well below the temperature at which ice crystals begin to form within the food. By reducing the temperature of the product to -10 to -20°C, the normal reactions that cause deterioration of foods are reduced to negligible or minimal rates. These temperature levels limit the growth of most microbial populations and eliminate microbial growth as a concern in shelf-life of the food product. As would be expected, the shelf-life of a frozen food is a function of temperature, with lower temperatures leading to longer shelf-life.
Stochastic Assembly Produces Heterogeneous Communities in the C. elegans Intestine

Host-associated bacterial communities vary extensively between individuals, but it can be very difficult to determine the sources of this heterogeneity. Here we demonstrate that stochastic bacterial community assembly in the C. elegans intestine is sufficient to produce strong inter-worm heterogeneity in community composition. When worms are fed with two neutrally-competing fluorescently labeled bacterial strains, we observe stochastically-driven bimodality in community composition, where approximately half of the worms are dominated by each bacterial strain. A simple model incorporating stochastic colonization suggests that heterogeneity between worms is driven by the low rate at which bacteria successfully establish new intestinal colonies. We can increase this rate experimentally by feeding worms at high bacterial density; in these conditions the bimodality disappears. These results demonstrate the potential importance of stochastic processes in bacterial community formation and suggest a role for C. elegans as a model system for ecology of host-associated communities.
AIBO goes to school: basic math

One of the objectives of AI involves creating applications or behaviors on machines that simulate intelligence. This paper presents an application of Neural Networks and Image Processing where AIBO solves mathematical expressions after learning to recognize numbers and operators via a combination of Offline Learning and Online Testing. This application results in a robot that exhibits intelligent behavior (as perceived by the onlooker) by being able to recognize and solve math problems as humans do and can be used as a platform for other recognition tasks.
Using Default Options to Increase Healthy Add-Ons to a Meal

Default options have a powerful effect on a broad range of decisions. We examine the degree to which default options can increase the consumption of healthy items as an add-on to a regular entree. We run an experiment in a college cafeteria in which we vary whether hamburgers are served automatically with tomatoes or whether the tomatoes have to be added by the customer. We find that including tomatoes by default more than doubles the fraction of customers eating a tomato with their hamburger (74% vs. 30%). We also use observational data from six restaurants that serve hamburgers and find that including a tomato by default significantly increases consumption of tomatoes. These results demonstrate that default options can work to improve healthy eating decisions.
A Tower to Console the Dead and the Living: Masumi Hayashi and the Image of History

This article critically investigates the work of the Japanese American photographer Masumi Hayashi (1945–2006), with special attention to her series on World War II era internment camps for people of Japanese ancestry. It has three goals: to describe Hayashi’s unusual working method through close attention to the works themselves; to articulate the aesthetic, philosophical and ethical dimensions of Hayashi’s practice; and to position Hayashi within the field of late twentieth-century and early twenty-first century photographers concerned with the problem of giving-image to traumatic histories. The author argues for recognition of Hayashi’s deeply accomplished, ground-breaking work.
Transformation of the Health Professional Workforce: Implications for Management Research

The purpose of this panel symposium is to discuss the significant theoretical issues, research opportunities, and policy implications that are emerging from ongoing changes within the US health pro...
Women’s Experiences in eSports: Gendered Differences in Peer and Spectator Feedback During Competitive Video Game Play:

Despite the growing popularity of eSports, the poor representation of women players points to a need to understand the experiences of female players during competitive gaming online. The present study focuses on female gamers’ experiences with positive and negative feedback and sexual harassment in the male-dominated space of eSports. In Study 1, gender differences were analyzed in online gamers’ experience with feedback from other players and spectators during online play. In Study 2, gender differences were analyzed in observations of real gameplay that focused on the types of comments spectators directed toward female and male gamers on Twitch (a popular video game streaming website). The findings suggest a mixed experience for women that includes more sexual harassment in online gaming compared with men.
Kinematic and Dynamic Reference Frames

The fundamental properties of kinematic and dynamic reference frames are defined, first as an abstract concept and second in a practical (although idealized) thought experiment. A four dimensional space-time description in coordinate free notation illustrates the properties, limitations, and relationships between kinematic and dynamic reference frames. Kinematic reference frames can be defined quite rigorously. Dynamic reference frames cannot be defined so well, but are nonetheless very useful. In practice a combination has been generally adopted. Presently we can materialize purely kinematic terrestrial and celestial reference frames.
Naptics: Convenient and Continuous Blood Pressure Monitoring during Sleep

Normal circadian rhythm mediates blood pressure during sleep, decreasing in value in healthy subjects. Current methods to monitor nocturnal blood pressure use an active blood pressure cuff that repeatedly auto-inflates while the subject sleeps. Since these inflations happen in intervals of thirty minutes to one hour, they cause considerable sleep disturbances that lead to false measurements and impact the person's quality of sleep. These blood pressure samples are also just spot checks and rarely exceed 10-15 values per night. We present Naptics, a wearable device woven into shorts. Naptics passively monitors the wearer's blood pressure throughout the night---continuously and unobtrusively---without disturbing the user during sleep. Naptics detects the micro-vibrations of the wearer's body that stem from the heartbeat and senses the optical reflections from the pulse wave as it propagates down the wearer's leg. From the timing between these two events, Naptics computes the pulse transit time, which correlates strongly with the user's blood pressure. Naptics' key novelty is its unobtrusive approach in tracking blood pressure during the night. Our controlled evaluation of six subjects showed a high correlation (r = 0.89) between Naptics' calibrated mean arterial pressure and cuff-based blood pressure. Our in-the-wild evaluation validates Naptics in tracking five participants' blood pressure patterns throughout four nights and compares them to before and after cuff measurements. In a majority of the nights, Naptics correctly followed the trend of the cuff measurements while providing insights into the behavior and the patterns of participants' nocturnal blood pressure. Participants reported high sleep quality in sleep diaries after each night, validating Naptics as a convenient monitoring apparatus.
Disease Caused by Mycobacterium Abscessus and Other Rapidly Growing Mycobacteria (RGM)

Rapidly growing mycobacteria (RGM) are divided into six major groups including the two clinically most important groups, M. chelonae/M. abscessus complex and Mycobacterium fortuitum group. This chapter discusses infections associated with these groups with an emphasis on pulmonary disease. Phenotypic and molecular laboratory identification methods are reviewed as accurate organism identification is necessary for optimal RGM lung disease patient management. Antimicrobial susceptibility patterns for the most common pathogenic RGM species are discussed with an emphasis on the impact of inducible macrolide resistance found in many RGM species and subspecies. Because of antibiotic resistance, the RGM are frequently difficult to treat successfully. Current therapeutic approaches are reviewed with an emphasis on antibiotic options in the context of both innate and acquired antibiotic resistance.
Characterizing behavioral adaptation to climate change in temperate forests

Abstract The potential impacts of climate change on terrestrial ecosystems are well recognized, and a wide variety of adaptation measures have been proposed. However, little is known about whether and how adaptation is occurring among people in these ecosystems. Understanding adaptation at the level of individuals, including members of households and extended families, is especially important because it is the level at which people most directly experience climate change impacts and engage in behavioral change. I offer a framework for characterizing the responses of individual landowners to climate change impacts in terms of adaptation behavior, and distinguishing adaptation from coping. The framework expands existing typologies of adaptation behavior to include a hierarchy of three analytical units of behavior: activities, practices, and strategies. I illustrate the framework by applying it to landowners’ responses to climate change impacts in temperate forests, a biome that is undergoing dramatic change. Individuals own and rely on large proportions of land in many temperate forest countries and are therefore exposed and sensitive to climate change impacts. Through management, they also influence how forests and their own well-being are affected by climate change. By improving characterizations of behavioral responses to climate change, the framework I propose can help researchers and practitioners evaluate progress toward adaptation with greater rigor.
EPIGENOME-WIDE ASSOCIATION ANALYSIS AND REPLICATION IMPLICATES DEREGULATION OF PCSK9 IN ALCOHOL USE DISORDER

Background Alcohol Use Disorder (AUD) is a common and chronic disorder with substantial effects on personal and public health. The underlying pathophysiology is poorly understood but strong evidence suggests significant roles of both genetic and epigenetic components. Methods Given that alcohol affects many organ systems, we performed a cross-tissue and cross-phenotypic analysis of genome-wide methylomic variation using Illumina HM450 and EPIC chip arrays in AUD samples from 3 discovery, 4 replication, and 2 translational cohorts. The discovery samples consisted of postmortem brain tissues (n=46), bloods form a resting-state functional connectivity imaging endophenotypes (n=68) and postmortem brain tissues sorted into neuronal and non-neuronal cells (n=58). Results Overrepresentation analyses identified 68 significant CpG probes of which the most significantly associated probe cg01444643 was in in the promoter of the proprotein convertase subtilisin/kexin 9 (PCSK9) gene (p=0.002). Biological validation showed that PCSK9 promoter methylation is conserved across tissues (brain-blood-liver) and positively correlated with expression. Replication in AUD datasets confirmed PCSK9 hypomethylation (n=392, p Discussion Our finding of alcohol-induced epigenetic regulation of PCSK9 represents one of the underlying mechanisms between the well-known effects of alcohol on lipid metabolism and cardiovascular risk, with light alcohol use generally being protective while chronic heavy use has detrimental health outcomes.
“We Are All Keynesians Now”: How the Revolution Transformed Our Economy and Culture

Reviews how the Consumption paradigm gained extensive influence over structures of our economic systems and broader culture. In particular, the chapter examines the role of economists like Milton Friedman and Paul Samuelson in framing what economics is and isn’t for the general public. Through their regular columns in Newsweek, Friedman and Samuelson influenced the way that a generation of Americans came to view economics and also themselves in relation to the economy. What they came away with was a sense that economics was about figuring out the best economic policies to attain goals like full employment, rather than seeing economics as something personal and meaningful. John Kenneth Galbraith had a similar impact through his book The Affluent Society, combining Keynesian economics with trenchant social analysis.
Left Main Coronary Interventions

Interventions of Left main coronary artery (protected and unprotected) require special and careful consideration of other lesions assessment, lesion preparation, and proper device selection and placement.
Exploring a Cultural Initiative: The Opus College of Business’s Mission-Driven Catholic Business Education Seminar

This article examines and evaluates the development, design, and impact of one strategy for renewing mission and identity in Catholic business education. The Mission-Driven Catholic Business Education (MCBE) Seminar is used by the Opus College of Business at the University of St. Thomas to create and sustain a mission-driven culture.
Delivering and nurturing a young journal: editorial

Founding Editor-in-Chief Bahaa Saleh reflects on the effort involved in launching the Advances in Optics and Photonics and its early evolution.
Risk-benefit value of upper extremity function by an implanted electrical stimulation device targeting chronic cervical spinal cord injury.

Study design A cross-sectional stated-preference survey using direct-assessment questions. Objective To determine the relative value placed on different outcomes to be used in a pivotal trial for the upper extremity configuration of the Networked Neuroprosthesis (NNP) as well as the tolerance of the expected adverse event profile. Setting Academic medical center in the United States. Methods Distribution of an online survey to adults living with tetraplegia; extent of agreement with each question/statement was obtaining using a 1-7 Likert scale. Results There were 8 statements about potential benefits in arm/hand function; for all statements, more than 70% of participants rated the functions as "1-very important" to regain. There were variable degrees of concern related to risks that could occur during the 30-day post-surgical period and increasing degrees of concern related to risks that could occur in the first 5 years, potentially due to the device, based on the increasing degree of invasiveness of the intervention required to address the event. When analysing the results based on all degrees of interest, more than 64% of responders were interested in getting the NNP with a success rate threshold as low as 50% regardless of time post-injury. Chi-squared analyses revealed some associations between responses and sex, injury level, and injury duration; however, none of these were statistically significant upon post-hoc analysis. Conclusion Data here indicate that people with tetraplegia are highly interested in a range of arm/hand functions and are tolerant of expected risks that may be associated with implanted neuroprosthetics. Sponsorship The Institute for Functional Restoration funded this project through a sub-contract to K.D. Anderson from a larger Special Projects Award (grant number FP0020773) from the Craig H. Neilsen Foundation.
Cardiac resynchronization therapy-heart failure (CRT-HF) clinic: A novel model of care

Background Post-implant care of patients with heart failure (HF) undergoing cardiac resynchronization therapy (CRT) is not addressed in current HF or CRT guidelines and is often fragmented with poor communication between specialties. We sought to develop a new model of post-CRT care which could be implemented in busy clinical settings. Methods and results We designed a novel, multidisciplinary approach to standardizing post CRT care. All patients receiving a CRT device at the Cleveland Clinic between March 2017 and August 2018 were invited to be seen in the clinic 6 months post implant. A one-time collaborative visit encompassing cardiac imaging, heart failure, and electrophysiology care was performed. We recorded the operational feasibility of the clinic in terms of patient throughput as well as patient characteristics, interventions, and new diagnoses made. Between September 2017 and February 2019, 150 patients were seen in the clinic. Of these, 125 patients had their index CRT implanted for standard indications and were included in the current analysis. Approximately 45 minutes were dedicated for each patient visit. Interventions in care were made in 95% of patients, with CRT non-responders offered a higher number of interventions as compared to responders (median 3 versus 2 interventions). Types of interventions were device-related (26% of population), medication-related (74%), and referral for alternate medical services (80%). Conclusions Multidisciplinary post-implant care of patients with HF receiving CRT devices, regardless of CRT response status, is feasible and results in frequent medical interventions.
Booster seats: new committee chairs and legislative effectiveness

Recent years have seen increased attention to legislative capacity and performance, including the development of individual Legislative Effectiveness (LE) scores for the US Congress. In comparing n...
Mesenteric lymphatic malformation mimicking an adnexal source in a teenager

Mesenteric lymphatic malformations are rare benign tumors that are usually found in children and very rarely are they found in the abdomen. We present a rare case in which a mesenteric lymphatic malformation mimics an adnexal source. This is an important contribution to obstetrics and gynecology literature to show the importance of keeping this rare diagnosis on the differential, as well as the value of multi-disciplinary care.
Time-Dependent Ginzburg–Landau (TDGL) Equations

The Initial microscopic derivation of TDGL equations was successfully performed by Eliashberg and Gor’kov. However, their theory, elucidated in Chap. 4, corresponds to the so-called gapless regime, where depairing factors (like magnetic impurities) squeeze the gap to zero, while leaving the Cooper condensate alive. Its quantum behavior is governed by this set of “gapless” TDGL equations.
Open-Loop Distributed Beamforming Using Scalable High Accuracy Localization.

We present a distributed antenna array supporting open-loop distributed beamforming at 1.5 GHz. Based on a scalable, high-accuracy internode ranging technique, we demonstrate open-loop beamforming experiments using three transmitting nodes. To support distributed beamforming without feedback from the destination, the relative positions of the nodes in the distributed array must be known with accuracies below $\lambda/15$ of the beamforming carrier frequency to ensure that the array maintains at least 90\% coherent beamforming gain at the receive location. For operations in the microwave range, this leads to range estimation accuracies of centimeters or lower. We present a scalable, high-accuracy waveform and new approaches to refine range measurements to significantly improve the estimation accuracy. Using this waveform with a three-node array, we demonstrate high-accuracy ranging simultaneously between multiple nodes, from which phase corrections on two secondary nodes are implemented to maintain beamforming with the primary node, thereby supporting open-loop distributed beamforming. Upon movement of the nodes, the range estimation is used to dynamically update the phase correction, maintaining beamforming as the nodes move. We show the first open-loop distributed beamforming at 1.5 GHz with two-node and three-node arrays, demonstrating the ability to implement and maintain phase-based beamforming without feedback from the destination.
The Effects of Anodal Transcranial Direct Current Stimulation on Sleep Time and Efficiency

A single session of anodal transcranial direct current stimulation (tDCS) has been shown to increase arousal in healthy participants for up to 24 h post-stimulation. However, little is known about the effects of tDCS on subsequent sleep in this population. Based on previous clinical studies, we hypothesized that anodal stimulation to the left dorsolateral prefrontal cortex (lDLPFC) would produce higher arousal with decreased sleep time and stimulation to the primary motor cortex (M1) would have the converse effect. Thirty-six active duty military were randomized into one of three groups (n = 12/group); active anodal tDCS over the lDLPFC, active anodal tDCS over left M1, or sham tDCS. Participants answered questionnaires 3 times a day and wore a wrist activity monitor (WAM) to measure sleep time and efficiency for 3 weeks. On weeks 2 and 3 (order counterbalance), participants received stimulation at 1800 h before 26 h of sustained wakefulness testing (sleep deprived) and at 1800 h without sleep deprivation (non-sleep deprived). There were no significant effects for the non-sleep deprived portion of testing. For the sleep deprived portion of testing, there were main effects of group and night on sleep time. The DLPFC group slept less than the other groups on the second and third night following stimulation. There is no negative effect on mood or sleep quality from a single dose of tDCS when participants have normal sleep patterns (i.e., non-sleep deprived portion of testing). The results suggest that stimulation may result in faster recovery from fatigue caused by acute periods of sleep deprivation, as their recovery sleep periods were less.
A Decision-Making Perspective to Negotiation: A Review of the Past and a Look to the Future

Over the past quarter century, the decision-analytic approach to negotiation has seen the development of a better dialogue between the descriptive and the prescriptive and has also attracted the interest of both academics and practitioners. Researchers have built upon the work in behavioral decision theory, examining the ways in which negotiators may deviate from rationality. The 1990s brought a renewed interest in social factors, as work on social relationships, egocentrism, attribution and construal processes, and motivated illusions was incorporated into our understanding of negotiations. Several promising areas of research have emerged in recent years, drawing from other disciplines and informing the field of negotiations, including work on the influence of ethics, emotions, intuition, and training.
Rethinking DNP education: Just another mountain to climb.

ABSTRACT The World Health Organization designated 2020 as the International Year of the Nurse and Midwife in celebration of the 200th birthday of Florence Nightingale, the founder of modern nursing. This article considers the future of nurse practitioner education in light of nursing history. First, a brief overview describes the progression of nursing education since the founding of the Nightingale School in 1860. Then, current challenges in NP education are discussed. Potential solutions to these issues are presented.
Enhanced Cooperation: The Ultimate Challenge of Managing Diversity in Europe - New Perspectives on the European Integration Process

Diversity in the EU has always been a permanent factor accompanying the European integration process. With the recent enlargement and those in the pipeline this diversity will grow, bringing the ultimate challenge for the continuity and feasibility of the integration process: the management of this increasing variety. The mechanism of enhanced cooperation was established in the Amsterdam Treaty to provide a solution to this challenge. The following article sheds some light on the future utilisation of this mechanism and its consequences and repercussions for the European integration process.
SCOPE: an open and softwarized prototyping platform for NextG systems

The cellular networking ecosystem is being radically transformed by openness, softwarization, and virtualization principles, which will steer NextG networks toward solutions running on "white box" infrastructures. Telco operators will be able to truly bring intelligence to the network, dynamically deploying and adapting its elements at run time according to current conditions and traffic demands. Deploying intelligent solutions for softwarized NextG networks, however, requires extensive prototyping and testing procedures, currently largely unavailable. To this aim, this paper introduces SCOPE, an open and softwarized prototyping platform for NextG systems. SCOPE is made up of: (i) A ready-to-use, portable open-source container for instantiating softwarized and programmable cellular network elements (e.g., base stations and users); (ii) an emulation module for diverse real-world deployments, channels and traffic conditions for testing new solutions; (iii) a data collection module for artificial intelligence and machine learning-based applications, and (iv) a set of open APIs for users to control network element functionalities in real time. Researchers can use SCOPE to test and validate NextG solutions over a variety of large-scale scenarios before implementing them on commercial infrastructures. We demonstrate the capabilities of SCOPE and its platform independence by prototyping exemplary cellular solutions in the controlled environment of Colosseum, the world's largest wireless network emulator. We then port these solutions to indoor and outdoor testbeds, namely, to Arena and POWDER, a PAWR platform.
Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy

The role of molecular chaperones, such as heat shock protein 70 (Hsp70), is not typically studied as a function of biological sex, but by addressing this gap we might improve our understanding of proteinopathic disorders that predominate in one sex. Therefore, we exposed male or female primary hippocampal cultures to preformed α-synuclein fibrils in a model of early-stage Lewy pathology. We first discovered that two mechanistically distinct inhibitors of Hsp70 function increased phospho-α-synuclein+ inclusions more robustly in male-derived neurons. Because Hsp70 is released into extracellular compartments and may restrict cell-to-cell transmission/amplification of α-synucleinopathy, we then tested the effects of low-endotoxin, exogenous Hsp70 (eHsp70) in primary hippocampal cultures. eHsp70 was taken up by and reduced α-synuclein+ inclusions in cells of both sexes, but pharmacological suppression of Hsp70 function attenuated the inhibitory effect of eHsp70 on perinuclear inclusions only in male neurons. In 20-month-old male mice infused with α-synuclein fibrils in the olfactory bulb, daily intranasal eHsp70 delivery also reduced inclusion numbers and the time to locate buried food. eHsp70 penetrated the limbic system and spinal cord of male mice within 3 h but was cleared within 72 h. Unexpectedly, no evidence of eHsp70 uptake from nose into brain was observed in females. A trend towards higher expression of inducible Hsp70—but not constitutive Hsp70 or Hsp40—was observed in amygdala tissues from male subjects with Lewy body disorders compared to unaffected male controls, supporting the importance of this chaperone in human disease. Women expressed higher amygdalar Hsp70 levels compared to men, regardless of disease status. Together, these data provide a new link between biological sex and a key chaperone that orchestrates proteostasis.
Research on financial Promotion of real Economy from the perspective of financialization

In recent years, with the continuous rise of China's economy and the continuous development of The Times, China's economic level has produced significant innovation, but it also highlights the obvious phenomenon that China's current financial and real economy are not coordinated. It is mainly manifested in the excessive expansion of the financial sector, and the allocation of the financial market has become a distorted state, which leads to the serious industrial hollowing and the concentration of financial risks, and to some extent limits the development of China's real economy. Therefore, China needs to strengthen in-depth research and exploration on the coordination between finance and the real economy. Finance and the real economy complement each other. In the future, the scientific strategy of promoting the development of the real economy through finance and improving the financial system can effectively improve the auxiliary efficiency of the financial economy to the real economy. This paper will further promote the coordinated development of finance and the real economy for analysis.
V Cavity Quantum Optics and the Quantum Measurement Process

Publisher Summary This chapter discusses the cavity quantum optics and the quantum measurement process. The chapter presents the important aspects of the Jaynes-Cummings model, describing the dipole interaction between a single two-level atom and a single mode of the electromagnetic field. The cavity quantum electrodynamics (QED) is discussed. The effects of enhanced and inhibited spontaneous emission in density-of-modes approach and the coupled-modes approach are also discussed. The central element of most of these experiments is the micromaser. The chapter treats quantum measurements in a way that emphasizes the difference between ensemble averages and repeated measurements on a single quantum system. Quantum nondemolition measurements are proposed as a way to eliminate this back action of the measurements on the state of the system. The chapter examines macroscopic superpositions of quantum states (Schrodinger cats) and of their generation in micromasers pumped by a stream of polarized atoms. Mechanical effects of light on the center-of-mass motion of atoms, combined with cavity QED, open up new opportunities to study the dynamics of the light-matter interaction and investigate the effects and potential uses of quantum measurements on single quantum systems.
ENZYMATIC REDUCTION OF SELENITE.

Abstract Nickerson, Walter J. (Rutgers, The State University, New Brunswick, N.J.) and Giuseppe Falcone. Enzymatic reduction of selenite. J. Bacteriol. 85:763–771.—1963. Extraction of boiled yeast extract with n-hexane removed its ability to restore selenite-reducing capacity in dialyzed enzyme preparations obtained from baker's yeast or from Candida albicans. Menadione or thiodione substituted for the quinone(s) extracted by n-hexane. Active components of the water-soluble, dialyzable fraction of yeast extract included: glucose-6-phosphate, triphosphopyridine nucleotide, and glutathione. Selenite appears to be bound to protein through vicinal thiol groups, and to be released therefrom as metallic selenium after accepting four electrons.
The N-terminal region of the Trypanosoma brucei Tim17 is critical for mitochondrial protein import (950.3)

The protein translocases of the mitochondrial inner membrane in higher eukaryotes, TIM23-17 and TIM22-54, possess three homologous proteins, Tim17, Tim23, and Tim22. In contrast, Trypanosoma brucei...
The language of Hinduism in the US diaspora

The use of English in rituals in the Hindu diaspora in the US is a major change for the religion, since English is excluded from Hindu rituals in India. This paper demonstrates that: (a) this change has impacted the structure of English and the system of Hinduism; (b) Hindu saints, the ‘authority’ in Hinduism, sanction this change; (c) the media further promotes it; and (d) it impacts the degree of functional load and transparency for the languages of rituals while creating di-systems, or mixed codes with two systems of thought. The implications of this discussion for the theory of language change, maintenance and loss of language will be presented.
Land Prices and Land Assembly in the CBD

There is substantial empirical evidence of price concavity in the parcel-size dimension across land-use types and across urban regions. This article examines the degree to which concavity varies between the Central Business District (CBD) and the rest of the urban area. The article provides strong empirical support that the degree of concavity within the CBD is lower than in the rest of the county. Although concavity may be the dominant pricing relationship throughout most urban areas, there is some evidence of the presence of a convex price structure within the urban center.
Effect of Legal Education Upon Perceptions of Crime Seriousness: A Response to Rummel v. Estelle

Retributive penal philosophy calls for punishment of a law violator to be proportional to the seriousness of the crime committed. However, proportionality is an elusive concept and is calculating differently, especially by utilitarians and retributivists. Studies have been conducted with the perception of students, occupational groups, and the general population. This article addresses the effect of legal education on law students in perceptions of crime including general ranking of crimes, perceived crime seriousness by harm, seriousness by mens rea, and seriousness by imputation.
Distributed Bragg Reflector Lasers

The sections in this article are 1 Dbr and Laser Basics 2 The Bragg Period 3 Edge-Emitting Single Frequency Lasers 4 Vcsel 5 Conclusion Keywords: bragg period; coupled mode theory; single frequency semiconductor lasers; reflectivity; DBR fabrications; VCSEL; tunable DBRs
A Brief History of Anticipatory Repudiation in American Contract Law

This article traces the evolution of the doctrine of anticipatory repudiation from its foundations laid years before the landmark case of Hochster v. De la Tour, 118 Eng. Rep. 922 (Q.B. 1853), through Hochster, its growing acceptance by American courts in the late-1800s and early-1900s, its canonization in the first Restatement of Contracts (despite the Restatement's principal Reporter's personal objections to the doctrine), its codification in the Uniform Commercial Code, its standardization in the Restatement (Second) of Contracts, and its inclusion in the U.N. Convention on Contracts for the International Sale of Goods. This article devotes considerable attention not only to judicial and legislative recognition (and, in limited cases, rejection) of the doctrine, but also scholarly support and criticism - particularly during the watershed period from the late-1800s through the mid-1930s. It also compares and contrasts the contours of the doctrine before and after each major evolutionary step.