cssi/SciSciGPT-SciSciNet huggingface dataset:
Cerebral correlates of psychotic symptoms in Alzheimer's disease

BACKGROUND—Psychotic symptoms are produced by distributed neuronal dysfunction. Abnormalities of reality testing and false inference implicate frontal lobe abnormalities. OBJECTIVES—To identify the functional imaging profile of patients with Alzheimer's disease manifesting psychotic symptoms as measured by single photon emission computed tomography (SPECT). METHODS—Twenty patients with Alzheimer's disease who had SPECT and clinical evaluations were divided into two equal groups with similar mini mental status examination (MMSE), age, sex, and the range of behaviours documented by the neuropsychiatric inventory (NPI), except delusions and hallucinations. SPECT studies, registered to a probabilistic anatomical atlas, were normalised across the combined group mean intensity level, and subjected to a voxel by voxel subtraction of the non-psychotic minus psychotic groups. Subvolume thresholding (SVT) corrected random lobar noise to produce a three dimensional functional significance map. RESULTS—The significance map showed lower regional perfusion in the right and left dorsolateral frontal, left anterior cingulate, and left ventral striatal regions along with the left pulvinar and dorsolateral parietal cortex, in the psychotic versus non-psychotic group. CONCLUSION—Patients with Alzheimer's disease who manifest psychosis may have disproportionate dysfunction of frontal lobes and related subcortical and parietal structures.
Encapsulation protocols for MPEG video in ATM networks

It is anticipated that video-on-demand and video as a component of multimedia services will be popular services provided by cable television and telephone companies. The proposed wide area network protocol for these services is the asynchronous transfer mode (ATM) based broadband integrated services digital network (BISDN). In order to provide research useful for this video networking effort, this paper details two protocols for packaging and reassembling Moving Picture Experts Group (MPEG) formatted video into and out of ATM cells. These protocol are then compared and contrasted in terms of: minimal generation of overhead; minimal system delay per cell; and best error recovery/concealment facilitation in the event of cell loss.
Usefulness of plasma phospholipid N-3 fatty acid levels in predicting dietary fish intake in patients with coronary artery disease

Abstract An association between decreased cardiovascular mortality and high dietary fish intake 1,5 has suggested a possible protective role for n-3 fatty acids against the development of coronary artery disease (CAD). An inverse relation has also been observed between the risk of CAD and eicosapentaenoic acid (EPA) levels in various tissues. 6–10 A reasonable but unproven assumption is that tissue levels of n-3 fatty acids correlate with dietary fish intake. To test this assumption, we investigated whether a relation exists between quantity of chronic fish consumption and levels of n-3 fatty acids in plasma phospholipids, using a previously validated food frequency questionnaire. 11 Plasma phospholipids were chosen because they are the plasma lipids least sensitive to changes in short-term dietary fat intake. 12,13 Patients with established CAD were chosen because they are the group in which n-3 fatty acid levels have been most intensively studied.
A System for Handling Unsolicited Postmarketing Study Proposals

Pharmaceutical companies frequently receive unsolicited study proposals from a va­ riety of individuals interested in conducting postmarketing studies with their prod­ ucts. A system for handling and funding these proposals has been developed by the Regional Research (RR) Group in the Department of Medical DevelopmentMarketed Products at Glaxo Inc. This group facilitates the processing, review, and follow-up of these proposals. Following committee review, approved studies are sup­ ported financially and monitored by the RR Group. The primary purposes for fund­ ing these studies are to: I) support marketed products through publications and pre­ sentations; 2)support efforts of sales representatives by providing them with a resource for responding to individuals interested in conducting clinical studies; and 3) encourage development of scientific data that may not conform to established clin­ ical programs. By providing this support, RR makes available a mechanism to spon­ sor studies not planned by the clinical and marketing groups, but considered interest­ ing and informative. Product visibility and public relations with the medical community are also enhanced through the support and successful completion of these studies.
The Final Tragedy

In general, the tragic tale of Werner’s final illness is well known. What is not widely known, however, is that this illness was preceded and foreshadowed by definite indications and warnings that might have been heeded by someone less compulsively dedicated to his science. It may come as a real surprise to many who knew him that the man who presented such a vigorous, active, and powerful figure to the outside world suffered from nervous headaches and signs of chronic overwork throughout much of his life. But Werner was not one to complain or indulge in self-pity. Perhaps if he had moderated his intense activity, perhaps if he had refrained from “burning the candle at both ends” year after year, his life might not have been cut short at the very zenith of his career.
The Color of Hell: Reframing Race and Justice in the Age of Mass Incarceration

In his 1903 book The Souls of Black Folk, W.E.B. DuBois (1903/1961) famously wrote, “The problem of the Twentieth Century is the problem of the color-line” (p. 23). More than a century later, racia...
Optimal M-estimation in high-dimensional regression

We consider, in the modern setting of high-dimensional statistics, the classic problem of optimizing the objective function in regression using M-estimates when the error distribution is assumed to be known. We propose an algorithm to compute this optimal objective function that takes into account the dimensionality of the problem. Although optimality is achieved under assumptions on the design matrix that will not always be satisfied, our analysis reveals generally interesting families of dimension-dependent objective functions.
Achieving Best Practice: A Review of Evidence Linked to Occupation-Focused Practice Models

The aim of this paper is to identify and synthesize evidence concerning the most widely used contemporary occupation-focused models including Ecology of human performance; Model of human occupation...
Duodenocaval Fistula: A Late Complication of Retroperitoneal Irradiation and Vena Cava Replacement

Duodenocaval fistula (DCF), an unusual pathology, is associated with a 40% mortality rate in the 36 patients previously reported. Although migrating or ingested foreign bodies, trauma, and peptic ulcer disease are often described etiologies, 11 patients have been described who developed DCF after resection of retroperitoneal tumors, 9 of whom also had postoperative radiotherapy. We report two patients who developed DCF after resection of retroperitoneal tumors followed by radiation therapy. The first patient, a 56-year-old female, presented with upper gastrointestinal hemorrhage requiring transfusion caused by a duodenoprosthetic caval fistula 7 years after successful resection of a retroperitoneal leiomyosarcoma and replacement of the inferior vena cava followed by radiation and chemotherapy. The second patient, a 37-year-old male who had previously undergone resection of a retroperitoneal sarcoma followed by external radiotherapy, developed massive upper and lower gastrointestinal bleeding secondary to a duodenocaval fistula. The etiology, diagnosis, and treatment of DCF are analyzed with an emphasis on DCF following resection and irradiation of retroperitoneal tumors. In most patients, “spontaneous” DCF have occurred as a late complication of high-dose radiation for carcinoma of the right kidney or retroperitoneal structures.
Intracortical pathways determine breadth of subthreshold frequency receptive fields in primary auditory cortex.

To examine the basis of frequency receptive fields in auditory cortex (ACx), we have recorded intracellular (whole cell) and extracellular (local field potential, LFP) responses to tones in anesthe...
Materiality and oral documents

Information professionals focus on artifacts. This focus shows the value information science has placed on materiality or physicality in its efforts to preserve and make artifacts in specific media accessible. But this focus has proven less useful when dealing with information that becomes available orally. As a strategy to increase understanding of oral information, Turner asserted that it can emerge as a type of artifact, an oral document: an utterance that conveys evidence, by what is said and by how it is uttered, and that incorporates properties of a document. This paper describes one of those properties, materiality, how it applies to non-written information in various literatures, and how the concept applies to oral documents. The authors then propose an exploratory, interdisciplinary research project to discern evidence of the materiality of oral documents in the brain via neuroimaging techniques.
Anxiety, Depression, and Functional Status are the Best Predictors of Health Status for Patients With Heart Failure

Abstract : Although mortality related to heart failure (HF) is high, the number of patients living with HF increases annually. Therefore, health status is an increasingly important concept in the management of HF. In fact, most symptomatic patients are more concerned about their everyday health status than the length of their life. Yet, most investigators conduct intervention studies that are designed to reduce mortality. As a result, health status is poorly understood for patients with HF. Thus, we conducted this study to identify predictors of health status. Methods: In this correlational study, we interviewed 87 patients (age 73 +-11 years; 48% female; ejection fraction EF 38 +-15%; New York Heart Association NYHA class III/IV 53%) immediately prior to discharge from a hospitalization for HF. Health status was conceptualized as health-related quality of life HRQOL (measured using the Minnesota Living with Heart Failure Questionnaire), actual physical activity level (measured over 24 hours using the Mini Mitter actigraph), and level of symptom burden (measured using the Dyspnea-Fatigue Index). Hierarchical multiple regression techniques were used to deterrnine sociodemographic (sex, age, living alone), clinical (comorbidities, NYHA class, EF), health perception, and emotional (anxiety, depression, and hostility measured using the Brief Symptom Inventory) variables associated with health status. Results: The model for each indicator of health status accounted for 37%, 52%, and 17% of the variance in HRQOL, symptom burden, and physical activity level, respectively. Variables independently associated with each indicator of health status are shown in the table. Based on the standardized beta coefficients, the three strongest predictors of health status were anxiety, NYHA class, and depression. Conclusions: Although emotional variables are not routinely assessed clinically, clearly they have a major impact on health status.
Secondary phase formation and the microstructural evolution of surface layers during vapor phase alteration of the French SON68 nuclear waste glass at 200 °C

The SON 68 inactive {open_quotes}R7T7{close_quotes} composition is the French reference glass for the LWR nuclear waste glass. Vapor phase alteration was used to accelerate the reaction progress of glass corrosion and to develop the characteristic suite of secondary, alteration phases. Extensive solid-state characterization (AEM/SEM/HRTEM) was completed on six inactive R7T7 waste glasses which were altered in the presence of saturated water vapor (200{degrees}C) for 91, 241, 908, 1000, 1013, and 1021 days. The AEM samples were examined in cross-section (lattice-fringe imaging, micro-diffraction, and quantitative thin-film EDS analysis). The glass monoliths were invariably covered with a thin altered rind. The layer became thicker with time: 0.5 {mu}m for 22 days; 4 {mu}m for 91 days; 6 {mu}m for 241 days; 10 {mu}m for 908 days; 26 {mu}m for 1013 days; and <35 {mu}m for 1021 days. The composite alteration layer of the SON 68 samples is at least four time less thick than that of the SRL 131 glass composition. Six distinctive zones, based on phase chemistry and microstructure, were distinguished within the well-developed surface layers. Numerous crystalline phases such as analcime, tobermorite, apatite, and weeksite were identified on the surfaces of the reacted glasses as precipitates. Two crystalline phases, Ag{sub 2}TeO{sub 3} and (Ca,Sr)Mo{sub 3}O{sub 9}(OH){sub 2}, were found within the inner zones of surface layers, and they must have nucleated in situ, indicating that Ag, Te, Sr, and Mo can be retained within the surface layer. The majority of the surface layer volume is composed of two morphologically and chemically different structures: one consists of well-crystallized fibrous smectite aggregates occurring along with cavities, the A-domain; and the other consists of poorly-crystallized regions containing needle-like smectite (montmorillonite) crystallites, a silica-rich amorphous matrix, and possibly ZrO{sub 2} particles, the B-domain.
Analysis of monomeric Aβ (1–40) peptide by capillary electrophoresis

A method was developed to characterize and quantify preparations of monomeric beta-amyloid (Abeta) peptide using capillary electrophoresis (CE) with UV absorbance detection. The detection limit for Abeta monomer using this method was 0.5 microM (19 pg). The self-assembly of Abeta to form amyloid fibrils is closely linked to Alzheimer's disease and is the subject of intense investigations. Consistent preparation of Abeta monomer samples at known concentrations and free of aggregates is a significant challenge for researchers studying the mechanism of Abeta fibril formation and searching for small molecules that inhibit Abeta fibril formation. Samples of Abeta monomer are known to sometimes contain pre-existing aggregates that can affect the kinetics and structure of amyloid fibrils. The CE method presented here showed that some of the monomeric Abeta samples prepared for this study contained a species producing a second peak (in addition to the major monomer peak). The aggregation was monitored using a thioflavin T fluorescence assay, and the resulting fibrils were characterized by transmission electron microscopy. Monomer samples containing the additional peak based on CE analysis were shown to aggregate more rapidly than monomer samples that were free of this putative Abeta aggregate peak.
Utilizing RADseq data for phylogenetic analysis of challenging taxonomic groups: A case study in Carex sect. Racemosae

PREMISE OF THE STUDY Relationships among closely related and recently diverged taxa can be especially difficult to resolve. Here we use both Sanger sequencing and next-generation RADseq data sets to estimate phylogenetic relationships among species of Carex section Racemosae (Cyperaceae), a clade largely restricted to high latitudes and elevations. Interest in relationships among these taxa derives from questions about the species' biogeographic histories and possible links between diversification and Pleistocene glaciations. METHODS A combination of approaches and molecular markers were used to estimate relationships among Carex species within sect. Racemosae and taxa from closely related sections. Nuclear and chloroplast loci generated by Sanger sequencing were analyzed with *BEAST, and SNP data from RADseq loci were analyzed as a concatenated data set using maximum likelihood and as independent loci using SVDquartets. KEY RESULTS Sanger sequencing data sets resolved relationships among taxa at intermediate phylogenetic depths (albeit with low levels of support). Only the RADseq data resolved relationships with strong support at all phylogenetic depths. Moreover, different methods and data partitions of the RADseq data resulted in nearly identical topologies. Carex sect. Racemosae is a strongly supported clade, although a handful of species were found to group with closely related sections. Herbarium specimens up to 35 yr old successfully produced informative RADseq data. CONCLUSIONS Despite the short read lengths of RADseq data, they nevertheless resolved relationships that Sanger sequencing data did not. Resolution of the phylogenetic relationships among recently and rapidly diversifying taxa within sect. Racemosae clades suggest a role for the Pleistocene glaciations in clade diversification.
Fiscal Policy Coordination with independent Monetary Policies - Is it possible?

The Stability Pact’s 3% of GDP limit on fiscal deficits has now been breached by six out twelve members of the Eurozone, and the Pact (in its original form) set aside following a decision in the European Court of Justice. The less controversial and less often quoted debt limit (at 60% of GDP) was breached by nine of twelve members in 1999; and six of them still breach it in 2005, although there have been big improvements in many cases. This record has raised understandable concerns about the discipline and degree of pre-commitment in fiscal policy, and the risks which that may pose in undermining the credibility and focus of monetary policy.
The Assessment of General Education Learning Outcomes in U.S. Government

This paper offers and analysis of the assessment of General Education Program learning outcomes in US Government courses at Valencia College. The General Education Program at Valencia is an integral part of the A.A. Degree program and is designed to contribute to the student’s educational growth by providing a basic liberal arts education. In an effort to improve student learning, faculty instruction, and program goals, faculty set out to identify a set of student learning outcomes for the General Education Program. After considerable discussion and debate 6 student learning outcomes were identified. Thus, a student who completes the General Education Program should have achieved the following outcomes: Cultural and Historical Understanding: Demonstrate understanding of the diverse traditions of the world, and an individual's place in it. Quantitative and Scientific Reasoning: Use processes, procedures, data, or evidence to solve problems and make effective decisions. Communication Skills: Engage in effective interpersonal, oral, and written communication. Ethical Responsibility: Demonstrate awareness of personal responsibility in one's civic, social, and academic life. Information Literacy: Locate, evaluate, and effectively use information from diverse sources. Critical Thinking: Effectively analyze, evaluate, synthesize, and apply information and ideas from diverse sources and disciplines. The next step in the process was to identify the General Education Program outcomes that students will demonstrate by completing our classes. Once Program outcomes were identified, faculty were responsible the assessment of these outcomes. US Government faculty identified four General Education Outcomes for our classes: Ethical Responsibility, Information Literacy, Cultural and Historical Understanding, and Critical Thinking. Plans were developed to assess these outcomes over a 4 year timeline. The analyses of Ethical Responsibility and Information Literacy outcomes have been completed with the remaining two outcomes to be assessed this year and next. This paper will discuss the assessment of Ethical Responsibility and Information Literacy General Education Program learning outcomes in US Government classes. It will look at how performance indicators were developed that align with specific course outcomes to assess General Education. The plan was to have faculty incorporate specific assignments in their courses and collect randomly selected artifacts of student work. These artifacts were subsequently scored according to a rubric and analyzed. The results of the assessment plans indicate that most students who take US Government demonstrate these General Education outcomes at a moderate or competent level. Overall the research indicates that US Government contributes in important ways to our General Education program and student learning.
Decomposition of Sulfur Hexafluoride By X-rays

The decomposition of gaseous sulfur hexafluoride (SF6) by exposure to high-energy photons, and the subsequent formation of toxic and corrosive oxyfluoride by-products, is of interest due to the use of SF6 as a high-voltage insulator near sources of radiation, such as particle accelerators and X-ray units. Additionally, information about by-product formation due to radiation exposure can be compared with data obtained for the decomposition of SF6 in electrical discharges.1,2 This comparison is interesting since the volume in which the decomposition occurs is usually many orders of magnitude larger for radiation exposure than for electrical discharges. However, little previous work has been done to determine the effects of radiation upon gaseous SF6.3
Design and Development of an Online Power Quality Monitoring Platform

In recent years,more and more attentions have been attracted to power quality.It has big significance to perform full and real-time monitoring of power quality.This paper introduces the design and development of the online power quality monitoring system in detail.In order to shield the heterogeneous of the data source,international general standard PQDIF is used as the data format to be stored and transmitted.Database optimization strategies like monthly partitioning and buffered committing are designed to deal with massive data.Rich client visualization technologies are used to enhance user experience.Furthermore,forewarning and estimation algorithms are exploringly introduced to supply powerful support to staff on decision making.
The Addition of Coaching to Cognitive Strategies

Urinary incontinence (UI) defined as the involuntary loss of urine sufficient to be a problem (UI Guideline Panel (UGIP, 1992), causes major physical, emotional, and social discomforts that are not often discussed with health professionals. Depression, physical unease, embarrassment, fear of discovery, and social isolation are common discomforts experienced by many persons (Dowd, 1991).
Exploring the Neuropsychological Antecedents of Transformational Leadership: the Role of Executive Function

This research explores brain-behavior relationships in prosocial, effective leadership by introducing executive function (higher-order brain function) as an individual difference. One hundred and five mid-level and senior managers were assessed on scientifically-valid neuropsychological tests that capture important dimensions of executive function. Two dimensions of executive function, control (inhibition of pre-potent response, flexible thinking) and decision-making, interacted to predict transformational leadership. This effect was found controlling for the extant antecedents of extraversion and general mental ability. Specifically, transformational leadership was associated with (1) high inhibition of pre-potent response in the presence of low-risk decision-making, and (2) either mental flexibility or low-risk decision-making, interchangeably. This suggests that the relationship between various executive function constructs and leadership is complex, and strengths in some cognitive capacities can substitute for limitations in others. Implications of the role of these interactions in facilitating transformational leadership are discussed.
Variation in the Small Guanosine Triphosphate (GTP)-Binding Protein, Secretion-Associated and RAS-Related (SAR1A) Gene and Response to Hydroxyurea Treatment in Sickle Cell Disease.

Hydroxyurea (HU) is a well-known chemotherapeutic agent and a potent ribonuclease reductase inhibitor that induces Hb F synthesis in sickle cell disease and some thalassemia syndromes. Our group has shown that the HU-inducible small guanosine triphosphate (GTP)-binding protein, secretion-associated and RAS-related (SAR) protein plays a role in g-globin gene induction and erythroid cell maturation by causing cell apoptosis and G1/S-phase arrest through the reduction of PI3 kinase and ERK phosphorylation and increased p21 and GATA2 expression. Our preliminary analysis indicates that HU inducibility is mediated at the transcriptional level, and is localized to elements in the SAR1A promoter. The aim of this study was to assess whether polymorphisms in the SAR1A gene promoter are associated with Hb F levels or HU therapeutic responses. We studied 386 sickle cell disease patients consisting of 269 adults treated with or without HU and 117 newborns with sickle cell disease identified from a newborn screening program. Twenty point mutations, including one nonsynonymous variant, were identified in SAR1A, including nine previously reported in SNP databases. A difference in genotype frequencies was observed between adults and newborns for rs2310991 in the 5′UTR (odd ratio [OR] = 1.9, 95% confidence interval [CI] = 1.1–3.2, P =0.009) and +31 T>C in 5′UTR (odd ratio [OR] 9.8 [ 1.3–73.9]; confidence interval [CI] 95%; P T, −502 G>T and −385 C>A) were significantly associated with the HbF response in Hb SS patients treated with HU ( P
Characterization and reconstruction of Laramide shortening and superimposed Cenozoic extension, Romero Wash-Tecolote Ranch area, southeastern Arizona

Laramide structures that are exposed along much of the Laramide porphyry copper province of southeastern Arizona have been dismembered and tilted by superimposed Cenozoic normal faults, such that the overall style of shortening (e.g., thin-skinned, low-angle thrusts versus basement-cored, moderate-angle reverse faults) is unclear pending a compelling reconstruction of superimposed extension. This study integrates new geologic mapping in the Romero Wash–Tecolote Ranch area with earlier work and utilizes palinspastic reconstructions of structures related to extension and shortening to determine the geometry of structures in this segment of the Laramide orogenic belt and their relationship to local products of magmatism and hydrothermal alteration. Geologic mapping indicates that multiple generations of Cenozoic normal faults can be identified through crosscutting relationships. Near both ends of the study area, the oldest synextensional strata dip vertically, indicating that the area has been tilted 90° eastward during extension. Structural reconstructions of normal faults reveal two reverse faults within the area, the Romero Wash fault and the Tecolote fault. Once restored, both faults originally dipped in opposite directions at moderate angles and demonstrate clear evidence for associated fault-propagation folds. As a result of 90°E tilting by Cenozoic normal faulting, the Romero Wash fault became an overturned reverse fault, whereas the Tecolote fault became an apparent normal fault. Constraints from the surface geology and forward models indicate that the Tecolote fault has ∼2.8 km of displacement on a fault that had an initial dip of 55°E, whereas the Romero Wash fault has ∼0.75 km of displacement on a fault that had an initial dip of 58°W. Considering their relative displacements and orientations, the Romero Wash fault is interpreted to be a backthrust to the Tecolote fault. These results are consistent with the interpretation that Laramide shortening in southeastern Arizona was dominated by basement-cored uplifts. Based on reconstruction of a cross section, the amount of Laramide shortening ( e = Δ l / l i ) in the study area was 1.8 km or 20%, and the total amount of subsequent Cenozoic extension ( e = Δ l / l i ) was 14.6 km or 200%. Two stocks of granodiorite, with associated porphyry dikes and related hydrothermal alteration, occur within the study area. Sericitic and ­propylitic ­alteration and sparse quartz veins are present without observed potassic altera­tion. A barren porphyry dike (65.9 ± 0.7 Ma, U-Pb zircon) cuts the Romero Wash fault, limiting the upper age of the fault. Similar dikes nearby are sericiti­cally altered, suggesting that alteration postdates shortening, similar to interpretations reached at the nearby porphyry copper systems of Ray, Resolution, and Kelvin-Riverside.
Concrete Pavements Curing Evaluation with Non-Destructive Tests

Abstract This study was completed by the Texas A&M Transportation Institute (TTI). The ground penetrating radar (GPR) technology and percometer were implemented for newly constructed highways. The GPR identifies the subsurface condition, which permits the user to determine the moisture availability for potential concrete curing. For this purpose, a GPR data acquisition program and data analysis system were developed by utilizing antenna. A combination of GPR information evaluation and curing quality evaluation is performed to diagnose the effectiveness of the applied curing compounds in terms of the moisture retention capability. Dielectric constant (DC) measurements were also taken on concrete specimens to indicate the free moisture content of the surface concrete. The new procedure consists of using measured relative humidity and temperature to calculate an Effectiveness Index (EI). EI and DC measurements indicate potentials to differentiate the curing quality of rigid pavement construction. Researchers examined the relationship between the Non-Destructive Testing (NDT) data and the actual concrete properties to develop “acceptability of quality” limits based upon the NDT data. The field investigations were conducted on two continuously reinforced concrete paving (CRCP) projects’ microfiber and internal curing mixtures.
A Chemoselective Rapid Azo-Coupling Reaction (CRACR) for Unclickable Bioconjugation

Chemoselective modification of complex biomolecules has become a cornerstone of chemical biology. Despite the exciting developments of the past two decades, the demand for new chemoselective reactions with unique abilities, and those compatible with existing chemistries for concurrent multisite-directed labeling, remains high. Here we show that 5-hydroxyindoles exhibit remarkably high reactivity toward aromatic diazonium ions and this reaction can be used to chemoselectively label proteins. We have previously genetically encoded the noncanonical amino acid 5-hydroxytryptophan in both E. coli and eukaryotes, enabling efficient site-specific incorporation of 5-hydroxyindole into virtually any protein. The 5-hydroxytryptophan residue was shown to allow rapid, chemoselective protein modification using the azo-coupling reaction, and the utility of this bioconjugation strategy was further illustrated by generating a functional antibody–fluorophore conjugate. Although the resulting azo-linkage is otherwise stabl...
Teaching Adrienne Rich

It is exciting and challenging to teach Adrienne Rich. Her poetry and prose raise many important questions for both students and teachers to explore. My discussion here will range briefly over what I consider some significant issues for educators, especially in the humanities, and then address some specifics of teaching practice. I include a short bibliography of books related to some of the topics mentioned in my overview.
Forging Selfhood: Social Categorisation and Identity in Arizona's Prison Wildfire Programme

This article examines the expressions of identity for participants in the Inmate Wildfire Program (IWP), a skilled prison labour programme in the US state of Arizona. The identity of imprisoned individuals is deleteriously shaped by the penal regime's construction of the social category ‘criminal’. Yet this process in not totalising. Using evidence drawn from 15 months of ethnographic fieldwork with prison wildfire fighters, I argue that participation in the IWP encourages critical thinking, access to open space, and interactions with the public, which destabilises the label of criminality and allows prisoners to engage in positive forms of identity construction. Prison officials can incorporate aspects of the IWP into other prison programmes in order to promote the construction of non‐carceral identities.
Case study on effective and elegant view of coffer slab

Nowadays, in the construction field, there are tremendous new technology and techniques used to give a decent look to the building so that the people get attracted towards the buildings and it will give the dealers and buyers to get through it. In this modern organization, the people demand that they have an innovative and creative design of the building for the aesthetic point of view. This paper represents that in the commercial building for the architectural consultant to design and shape by the coffer slab with different types of moulds used as per the drawings that are required by the client perspective and overview.
Latent Profile Analyses of Depressive Symptoms in Younger and Older Oncology Patients.

The aging of America will include a significant increase in the number of older patients with cancer, many of whom will experience significant depressive symptoms. Although geriatric depression is ...
Accelerated chilling of carcasses to improve pork quality.

Our objectives were to determine the optimal accelerated chill time immediately postmortem necessary to improve the quality of pork muscle and to decrease the incidence of pale, soft, and exudative pork. Carcasses from 81 market hogs were cooled either by conventional chill (CC) at 2 degrees C or by accelerated chill (AC) at -32 degrees C for 60, 90, 120, or 150 min, and then placed into a 2 degrees C cooler for the remainder of the 24-h chill period. Loin muscle pH was higher (P 0.05) affected by AC. In addition, AC did not (P > 0.05) affect purge, drip, or thaw loss of fresh products, sensory scores of loins or processed hams (except initial juiciness; P 0.05) affected by AC. Accelerated chilling caused loins to be darker (lower L* value; P < 0.05) and to have lower (P < 0.05) b* values (less yellow) than CC loins. Accelerated chilling increased water-holding capacity in fresh hams, bound water being the greatest (P < 0.05) in the 120- and 150-min AC groups. These results demonstrate that improvements in pork loin quality can be made using freezer-accelerated chilling for carcasses.
Linear Regression Using Multiple-Criteria

The unknown parameters in multiple linear regression models can be estimated using any one of a number of criteria such as the minimum sum of squared errors MSSE criterion, the minimum sum of absolute errors MSAE criterion, and the minimization of the maximum absolute error MMAE criterion. However, the MSSE criterion is still the most popular criterion with researchers.
Survey of Alkali Primary Ion Sources for SIMS

Since the first studies of negative ion yield enhancement by alkali ion bombardment [1,2], it has been natural to assume that cesium was the primary ion species of choice. Cesium is the most electropositive of the stable alkali metals and produces the lowest work function upon adsorption, implying that its effect on negative ionization efficiencies should be greater than that of the other alkalis. Further, because cesium has the lowest ionization potential of the stable alkali metals, and is the most volatile, it has appeared easiest to generate a Cs+ ion beam. Ion sources capable of generating stable Cs+ ion beams of several microamperes for several hundred hours have been used in SIMS since 1977 [3,4]. In 1978, DELINE et al. [5] and later CHELGREN et al. [6] observed that the ion yield for Si− sputtered by Cs+ from Pt2Si was about three orders of magnitude lower than the yield of Si− from silicon, mainly because the very high sputtering yield of Pt2Si under Cs+ bombardment led to a low surface concentration of implanted Cs. From the steep dependence of ionization efficiency on Cs surface concentration in a range of noble metal silicides (the Si− yield varied with [Cs]3·7), it appeared that sputtering with a lighter alkali species, with lower sputtering yield, might give higher ionization efficiencies due to the higher level of incorporated alkali, even though, at the same concentration, the lighter alkalis enhance negative ion yields less than does Cs [7]. The present study compares ion source performance for Na+, K+, Rb+ and Cs+ beams and yields of Si− sputtered from a silicon target by these species.
Acting Out in the Older Adolescent

Jackie, who is almost 17, has been caught shoplifting. She tried to take a pair of jeans and a sweater from a department store. She has been coming home late every night and sometimes does not get home until the next afternoon. She spends her evenings with different young men. She has not been going to school. What can be done to help her? How can psychotherapy be of help?
Patterns of recurrence and retreatment outcomes among clinical stage I and II head and neck melanoma patients.

Background The objective of this study was to determine survival outcomes in patients who underwent retreatment of recurrent cases of cutaneous melanoma of the head and neck (CMHN). Methods Retrospective review of all patients who were treated for primary clinical stage I or II CMHN between January 1, 2000 and December 31, 2015. Results Twenty percent (33/168) of the patients developed a recurrence. Sixty-six percent (4/6) of patients who developed local recurrence first and 50% (3/6) of patients who developed regional recurrence first were alive without evidence (NED) of disease at last follow-up, while 0% (0/21) of patients who developed distant or simultaneous recurrences first were NED at last follow-up. Among the 7 patients who were NED, the mean time from recurrence to last follow-up was 735 days. Conclusions Of patients with isolated local or regional recurrences, 58% (7/12) obtained durable curative treatment for recurrent melanoma.
Evaluation of Friction Behavior and Contact Area Dependence at the Micro and Nanoscales

In this work, we have compared the friction behavior of two different materials (a) mica and (b) ultra-high molecular weight polyethylene (UHMWPE) at two length scales. The friction experiments were carried out at the nanoscale with an atomic force microscope (AFM) and at the microscale, with a custom-built microtribometer. The material interface (Si3 N4 probe) and the environmental conditions (RH < 10%) were kept the same at both the scales. The friction data obtained were analyzed for dependence on normal load or contact area, based on which, a coefficient of friction has been reported or an appropriate contact mechanics theory was applied and an interfacial shear strength value was calculated for the material pair. Friction between a silicon nitride and UHMWPE interface resulted in contact area dependence at both the length scales, for the applied load ranges of our experiment. Friction between silicon nitride and mica at the nanoscale showed an initial nonlinearity and then exhibited damage and linearity with normal load beyond certain loads. At the microscale, the mica-silicon nitride interface resulted in a linear friction behavior.Copyright © 2007 by ASME
Docetaxel in Combination With Platinums in Patients With Advanced Non- Small-Cell Lung Cancer

Docetaxel (Taxotere) is a semisynthetic taxoid that possesses significant activity as a single agent in the treatment of patients with non-small-cell lung cancer. In previously untreated patients with non-small-cell lung cancer, 100 mg/m2 of docetaxel administered as an intravenous infusion over 1 hour once every 3 weeks produced response rates that ranged from 21% to 38% and median survivals of 25.2 to 47.0 weeks. In patients with advanced non-small-cell lung cancer who had previously failed cisplatin (Platinol)-based chemotherapy, docetaxel produced median response rates of 20% to 21% and median survival of 28 to 42 weeks. This review summarizes results from key phase I and II studies demonstrating the antitumor activity and tolerability of docetaxel combined with platinum compounds for patients with advanced non-small-cell lung cancer. Phase I trials determined that 75 mg/m2 of docetaxel and 75 mg/m2 of cisplatin is the recommended dose for phase II and III trials. Overall, response rates with docetaxel and cisplatin have ranged from 21% to 48% and median survival of 8 to 13 months has been achieved in phase II trials. Regarding docetaxel and carboplatin, results from phase I trials in patients with nonhematologic solid tumors indicate that this combination is well tolerated. The maximum tolerated dose of docetaxel in combination with carboplatin (target area under the time-concentration curve of 6 mg/mL.min) is 90 mg/m2 without granulocyte-colony stimulating factor (G-CSF) (filgrastim [Neupogen]) support and 100 mg/m2 with G-CSF support. The combination of docetaxel and carboplatin is presently being evaluated in a multicenter phase II study for patients with advanced non-small-cell lung cancer.
The archaeology of military prisons from the American Civil War: globalization, resistance and masculinity

Archaeologies of internment present unique challenges and benefits. Myriad aspects of human behaviour that stretch over temporal scales of generations and centuries at other archaeological sites ar...
A randomized phase II study of MLN0128 (M) versus pazopanib (P) in patients (pt) with advanced sarcoma (Alliance A091304).

11562Background: Soft tissue sarcoma (STS) is a heterogeneous malignancy of connective tissue. Although mTOR is implicated in STS pathogenesis, clinical activity from mTORC1 inhibitors is modest. M...
Outcomes of urgent/emergent transcatheter mitral valve repair (MitraClip): A single center experience.

Objectives To describe the outcomes of urgent/emergent transcatheter edge-to-edge mitral valve repair (TMVr) and compare the clinical, echocardiographic, and procedural characteristics of survivors and nonsurvivors. Background TMVr is a treatment strategy for select patients with severe primary or secondary mitral regurgitation. However, knowledge regarding outcomes for urgent/emergent TMVr is limited. Methods All urgent or emergent TMVr procedures using MitraClip performed at the University of Washington Medical Center between January 2018 and March 2019 were identified and clinical, echocardiographic, hemodynamic, procedural, and outcomes data were obtained by chart review. Outcomes included all-cause mortality, hospital mortality, procedural success, periprocedural complications, and hospital readmission. Results Of the 20 patients who underwent urgent/emergent TMVr, eight were treated for cardiogenic shock (CS), four for acute decompensated heart failure (ADHF) with hypoxemic respiratory failure requiring mechanical ventilation, and eight for ADHF with failure of inpatient medical therapy. Mechanical circulatory support (MCS) was used in six patients; preceding TMVr in three patients and immediately post-TMVr in three patients. Overall, 30-day mortality and hospital readmission rates were 21 and 13%, respectively. Over a median 153 days (IQR 20-491) of follow-up, 10 patients (50%) died. Preprocedure CS, new or ongoing MCS post-TMVr, refractory respiratory failure post-TMVr, and acute kidney injury post-TMVr were associated with mortality. Conclusions In a single-center retrospective analysis, urgent/emergent TMVr in high-risk patients with ADHF or CS was associated with high short-term mortality and periprocedural complications. Prospective studies are warranted to inform patient selection and periprocedural management for urgent/emergent TMVr.
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs

Cell-fate conversion generally presumes the activity of transcription factors to introduce fate programs of the target cell type in the midst of a pre-existing genetic network. Here, we reveal novel insights into cellular reprogramming in which microRNAs, miR-9/9* and miR-124 (miR-9/9*-124), orchestrate direct conversion of human fibroblasts by first eradicating fibroblast identity and promoting uniform transition to a neuronal state in sequence. Among the direct target genes of miR-9/9*-124, we identify KLF-family transcription factors whose repression is critical for erasing fibroblast fate. The subsequent upregulation of a small nuclear RNA, RN7SK induces chromatin reconfiguration and neuronal gene activation, pushing the reprogramming cells to a neuronal state and allowing for neuronal maturation and subtype-specification. Our study defines deterministic components in the reprogramming cascade by microRNAs.
Manipulability of Future‐Independent Tests

The difficulties in properly anticipating key economic variables may encourage decision makers to rely on experts' forecasts. Professional forecasters, however, may not be reliable and so their forecasts must be empirically tested. This may induce experts to forecast strategically in order to pass the test. A test can be ignorantly passed if a false expert, with no knowledge of the data-generating process, can pass the test. Many tests that are unlikely to reject correct forecasts can be ignorantly passed. Tests that cannot be ignorantly passed do exist, but these tests must make use of predictions contingent on data not yet observed at the time the forecasts are rejected. Such tests cannot be run if forecasters report only the probability of the next period's events on the basis of the actually observed data. This result shows that it is difficult to dismiss false, but strategic, experts who know how theories are tested. This result also shows an important role that can be played by predictions contingent on data not yet observed.
Cryptogenic new-onset refractory status epilepticus (NORSE) following blood transfusion in a patient with severe anemia

New-onset refractory status epilepticus (NORSE) is a rare neurological emergency in which a patient without prior seizure disorder develops seemingly unprovoked status epilepticus refractory to treatment. We report the case of a middle-aged woman who developed NORSE after receiving multiple blood transfusions for subacute blood loss anemia secondary to menorrhagia. Although the mechanism is unclear, we propose that sudden changes in blood viscosity and vasogenic tone resulted in cortical edema and irritation. Although seizures have been documented in patients who undergo blood transfusion and develop posterior reversible encephalopathy syndrome (PRES), there was no radiographic evidence of PRES in this case. This is the first reported case of cryptogenic NORSE following blood transfusion.
Quadrupole collectivity in the neutron-rich sulfur isotopes S 38 , 40 , 42 , 44

Electromagnetic transition strengths in the even-even neutron-rich sulfur isotopes $^{38,40,42,44}\mathrm{S}$ were measured using intermediate-energy Coulomb excitation at the National Superconducting Cyclotron Laboratory. By utilizing the sensitivity of the experimental technique to $E2$ excitations from the ground state, the evolution of the pattern of $B(E2)$ strengths to several low-lying ${2}^{+}$ states was investigated at $Z=16$ from near stability to the $N=28$ island of inversion. The experimental results allowed a detailed comparison with predictions from shell-model calculations using the SDPF-MU Hamiltonian, which was designed to describe collectivity in this region of the nuclear chart. While the shell-model calculations succeeded in modeling transition strengths at $N=22,24,26$, the experimental $B(E2;{0}_{1}^{+}\ensuremath{\rightarrow}{2}_{1}^{+})$ at $N=28$ was smaller than the predicted value by about a factor of 2, similar to previous observations for chlorine and argon isotopes around $N=28$. The dependence of this overprediction by theory on the choice of effective charges was explored.