cssi/SciSciGPT-SciSciNet huggingface dataset:
Synthesis of reversible logic circuits

Reversible or information-lossless circuits have applications in digital signal processing, communication, computer graphics, and cryptography. They are also a fundamental requirement in the emerging field of quantum computation. We investigate the synthesis of reversible circuits that employ a minimum number of gates and contain no redundant input-output line-pairs (temporary storage channels). We prove constructively that every even permutation can be implemented without temporary storage using NOT, CNOT, and TOFFOLI gates. We describe an algorithm for the synthesis of optimal circuits and study the reversible functions on three wires, reporting the distribution of circuit sizes. We also study canonical circuit decompositions where gates of the same kind are grouped together. Finally, in an application important to quantum computing, we synthesize oracle circuits for Grover's search algorithm, and show a significant improvement over a previously proposed synthesis algorithm.
Characterization, simulation, and modeling of FET source/drain diffusion resistance

We present an innovative and comprehensive approach to characterize and model FET source/drain diffusion resistance. We present a set of new SPICE models for the parasitic resistance in FET source and drain regions. Our FET source/drain diffusion resistance model has been verified with field solver simulation results, and is found to be very accurate over a wide range of parameter values. We also present a set of micro testing structures to measure and characterize diffusion resistance. This approach has been validated using hardware data from a 65 nm SOI technology.
SQL.CT: Providing Data Management for Visual Exploration of CT Datasets

We present the design and implementation of SQL.CT, a prototype for managing, querying, and visualizing 3D CT (Computed Tomography) datasets. The system is motivated by scientific studies of fossil records. Our prototype is built on top of SQL Server 2005 and uses both web service and service broker technologies. The desktop client utilizes commodity graphics cards to interactively render 3D volumes. This paper presents the user requirements, discusses the design of the data model and desktop client, and reports on preliminary performance measurements. Our experiments show that by pushing the spatial logic as low as possible into the DBMS, we can filter the data early. We observe some significant performance benefits from the reduced message traffic to and from the remote client.
Learning partially observable deterministic action models

We present the first tractable, exact solution for the problem of identifying actions' effects in partially observable STRIPS domains. Our algorithms resemble Version Spaces and Logical Filtering, and they identify all the models that are consistent with observations. They apply in other deterministic domains (e.g., with conditional effects), but are inexact (may return false positives) or inefficient (we could not bound the representation size). Our experiments verify the theoretical guarantees, and show that we learn STRIPS actions efficiently, with time that is significantly better than approaches for HMMs and Reinforcement Learning (which are inexact). Our results are especially surprising because of the inherent intractability of the general deterministic case. These results have been applied to an autonomous agent in a virtual world, facilitating decision making, diagnosis, and exploration.
Chloramphenicol: relation of structure to activity and toxicity.

The availability of an increasing number of effective broad spectrum anti­ microbials in the past decade has diminished considerably the clinical in­ dications for chloramphenicol (CAP). However, interest in this antibiotic has recently been revived both because of its antimicrobial activity and its toxic­ ity. Some factors affecting its resurgence are the emergence of ampicillin­ resistant Halmophilus influenzae, the superiority of CAP in fighting certain anaerobic infections and infections of the central nervous system, and the development of sensitive assays for the antibiotic and some of its metabolites in body fluids. Greater attention, however, has focused on hematotoxicity from CAP and its pathogenesis. The extensive use of a CAP analogue, thiamphenicol (TAP), in Europe and the Far East, without an increase in the incidence of associated aplastic anemia, has revived interest in the structure­ toxicity relationship in the CAP molecule and has focused attention on the P-N02 group as the structural feature that probably underlies the development of bone marrow aplasia in association with administration of CAP. TAP, with a similar antimicrobial spectrum, has emerged as a challenging substitute to CAP. In this chapter the comparative metabolism and toxicity of CAP and TAP are reviewed with particular emphasis on the role of the P-N02 group. For a clearer perspective, the properties of CAP, its mechanism of action, and relation of structure to activity and to bacterial resistance are briefly consid­ ered.
Business Process Integration of Multiple Customer Order Review Systems

Mergers and acquisitions of small- to medium-size manufacturing firms often result in an inefficient system of operations. A major issue is how to integrate existing operations from different business processes to streamline service and exploit economy of scales. Standard methodologies are often not adequate in these situations and there is a need for a new methodology to focus on consolidation of processes. We develop a mathematical model of the problem and show that the integration problem can be solved by quantitative techniques such as optimization and Monte Carlo simulation. We study general properties of the model and apply it to the consolidation of the contract review system of a particular company. We show that our approach not only improved the overall performance of this company but also can be used for other companies in similar situation.
The Rental Housing Affordability Gap: Comparison of 2001 and 2003 American Housing Surveys

Presents a mismatch analysis of the gap between what renter households can afford and the currently available stock of rental housing from the 2001 and 2003 American Housing.
The Pharmacology of Indomethacin.

Background Over 50 years ago, indomethacin emerged as an extremely potent non-steroidal anti-inflammatory drug (NSAID) during a massive effort to find effective anti-inflammatory and analgesic medications. The 1960s saw acetic acid derivatives developed into indomethacin, diclofenac, and sulindac, and propionic derivatives into ibuprofen, naproxen, and ketoprofen. Indomethacin was likely the most potent of these compounds and one of the earliest to enter clinical trials. It is not surprising that indomethacin was among the first of the NSAID medications to be used in treatment of migraine and for headaches that eventually became known as “indomethacin-responsive” headache disorders. Potential pharmacokinetic and bio-mechanistic differences between indomethacin and other NSAIDs are of great clinical and research interest to explain this observation. Methods/Results The present article summarizes pharmacologic properties of indomethacin, including pharmacokinetics with particular attention to its distribution into the central nervous system, adverse effects, drug interactions, and mechanisms of action. Data are emphasized where differences in biomechanisms are found between indomethacin and other NSAIDs. The use of indomethacin in pregnant and lactating women is reviewed. Conclusions NSAIDs easily enter the brain, but their high protein binding limits absolute amount of entry. All work similarly as either nonselective or selective cyclooxygenase inhibitors, but indomethacin may have more potent vasoconstrictive activity and unique direct neuronal or nitric oxide-dependent inhibitory pathway activity.
Chinese Public Diplomacy: The Rise of the Confucius Institute

1. Introduction 2. China on the Global Stage: Foreign Policy Implications and Image Considerations 3. How States Communicate: Public Diplomacy and Related Concepts 4. Public Diplomacy in China 5. China's Public Diplomacy at Work: Major Actors and Main Programs 6. Confucius Institutes: The Star of China's Public Diplomacy 7. Confucius Institutes in Australia 8. Confucius Institutes in Germany 9. Confucius Institutes: The Real Versus the Correct China
Observation of the Effect of Hyperbaric Oxygenation on Children Cortical Blindness

Objective Observe the result of hyperbaric oxygenation on children cortical blindness.Methods Use hyperbaric oxygenation among 21 cases of children cortical blindness,observe its effect.Results Effective:7cases(33%);improved:10 cases(48%);ineffective:4 cases(19%);to sum up,effective in 81% of cases.Conclusion Hyperbaric oxygenation is a very effective method on children cortical blindness,which opens up a new treatment on cortical blindness.
A New Network Control Approach Based on Drive Nodes

One of the difficulties on the research of directed network is the huge calculation when traditional network control theroy is applied to the network whose size and link weight are large.This paper presents an approach,which let the whole directed network be controlled based on drive nodes,through the research on the structure control theory.The set of drive nodes are found out which have some common characteristics and verify that controlling the set is equivalent to controlling the whole network.To a great extent,this approach can reduce the calculation.Simulation results prove the effectiveness and the practice sense of the approach.
SU-F-T-181: Proton Therapy Tissue-Equivalence of 3D Printed Materials

Purpose: This work investigated the proton tissue-equivalence of various 3D printed materials. Methods: Three 3D printers were used to create 5 cm cubic phantoms made of different plastics with varying percentages of infill. White resin, polylactic acid (PLA), and NinjaFlex plastics were used. The infills ranged from 15% to 100%. Each phantom was scanned with a CT scanner to obtain the HU value. The relative linear stopping power (RLSP) was then determined using a multi-layer ion chamber in a 200 MeV proton beam. The RLSP was measured both parallel and perpendicular to the print direction for each material. Results: The HU values of the materials ranged from lung-equivalent (−820 HU σ160) when using a low infill, to soft-tissue-equivalent 159 (σ12). The RLSP of the materials depended on the orientation of the beam relative to the print direction. When the proton beam was parallel to the print direction, the RLSP was generally higher than the RLSP in the perpendicular orientation, by up to 45%. This difference was smaller (less than 6%) for the materials with 100% infill. For low infill cubes irradiated parallel to the print direction, the SOBP curve showed extreme degradation of the beam in the distal region. The materials with 15–25% infill had wide-ranging agreement with a clinical HU-RLSP conversion curve, with some measurements falling within 1% of the curve and others deviating up to 45%. The materials with 100% infill all fell within 7% of the curve. Conclusion: While some materials tested fall within 1% of a clinical HU-RLSP curve, caution should be taken when using 3D printed materials with proton therapy, as the orientation of the beam relative to the print direction can result in a large change in RLSP. Further investigation is needed to measure how the infill pattern affects the material RLSP. This work was supported by PHS grant CA180803.
Evaluation of Pb–17Li compatibility of ODS Fe-12Cr-5Al alloys

Abstract The Dual Coolant Lead Lithium (DCLL: eutectic Pb–17Li and He) blanket concept requires improved Pb–17Li compatibility with ferritic steels in order to demonstrate acceptable performance in fusion reactors. As an initial step, static Pb-17at.%Li (Pb-17Li) capsule experiments were conducted on new oxide dispersion strengthened (ODS) FeCrAl alloys ((1) Y2O3 (125Y), (2) Y2O3 + ZrO2 (125YZ), (3) Y2O3 + HfO2 (125YH), and (4) Y2O3 + TiO2 (125YT)) produced at ORNL via mechanical alloying (MA). Tests were conducted in static Pb–17Li for 1000 h at 700 °C. Alloys showed promising compatibility with Pb–17Li with small mass change after testing for 125YZ, 125YH and 125YT, while the 125Y alloy experienced the highest mass loss associated with some oxide spallation and subsequent alloy dissolution. X-ray diffraction methods identified the surface reaction product as LiAlO2 on all four alloys. A small decrease (∼1 at.%) in Al content beneath the oxide scale was observed in all four ODS alloys, which extended 60 μm beneath the oxide/metal interface. This indicates improvements in alloy dissolution by decreasing the amount of Al loss from the alloy. Scales formed on 125YZ, 125YH and 125YT were examined via scanning transmission electron microscopy (S/TEM) and revealed incorporation of Zr-, Hf-, and Ti-rich precipitates within the LiAlO2 product, respectively. This indicates an inward scale growth mechanism. Future work in flowing Pb–17Li is needed to further evaluate the effectiveness of this strategy in a test blanket module.
Health sciences librarians off the radar

The library environment has undergone tremendous change through the years and with that change, the profession has had to adapt. These seemingly simple phrases written more than forty years ago continue to be as meaningful and applicable today as they were when written: “like everything else, libraries and library methods are changing at an increasing rate,” and “‘new things' have been and are happening in your field, and, indeed, some of these new trends seem to have come upon us quickly and, in some instances, have become drastic enough to threaten the very existence of the relatively small, professionally-supported medical library” [1]. Many health sciences libraries have adapted to accelerated technological advancements, fragmented collection acquisition models, altered space allocations, and modified user viewpoints. Particularly, health sciences libraries in hospitals have been profoundly impacted with library closures, bringing forth new thoughts related to value, adaptation, and change. In essence, this seemingly new trend of closures experienced today may not be so new after all, and the question that must be asked is, how has the health sciences hospital library continued to survive through the years?
Measurement of bb¯ rapidity correlations in pp¯ collisions at s=1.8 TeV

We report the first direct measurement of bb(bar sign) rapidity correlations in pp(bar sign) collisions at {radical}(s)=1.8 TeV. We select events with a high transverse momentum muon accompanied by a jet, and a second jet associated with a decay vertex displaced from the pp(bar sign) interaction vertex. Two independent samples are obtained corresponding to events with a forward (2.0<|{eta}|<2.6) or central (|{eta}|<0.6) muon. We measure the ratio of forward to central bb(bar sign) production to be 0.361{+-}0.033(stat){sub -0.031}{sup +0.015}(syst), in good agreement with the next-to-leading order QCD prediction 0.338{sub -0.097}{sup +0.014}. (c) 1999 The American Physical Society.
Synergistic effects of engineered nanoparticles and organics released from laser printers using nano-enabled toners: potential health implications from exposures to the emitted organic aerosol

Recent studies have shown that engineered nanoparticles (ENPs) are incorporated into toner powder used in printing equipment and released during their use. Thus, understanding the functional and structural composition and the potential synergistic effects of this complex aerosol and released gaseous co-pollutants is critical in assessing their potential toxicological implications and risks. In this study, toner powder and PEPs were thoroughly examined for the functional and molecular composition of the organic fraction and the concentration profile of 16 Environmental Protection Agency (EPA)-priority polycyclic aromatic hydrocarbons (PAH) using state-of-the-art analytical methods. Results show significant differences in abundance of the non-exchangeable organic hydrogen of toner powder and PEPs, with a stronger aromatic spectral signature in PEPs. Changes in the structural composition of PEPs are indicative of radical additions and free-radical polymerization favored by catalytic reactions, resulting in formation of functionalized organic species. Particularly, accumulation of aromatic carbons with strong styrene-like molecular signatures on PEPs is associated with formation of semi-volatile heavier aromatic species (i.e., PAHs). Further, the transformation of low molecular weight PAHs in the toner powder to high molecular weight PAHs in PEPs was documented and quantified. This may be a result of synergistic effects from catalytic metal/metal oxide ENPs incorporated into the toner and the presence/release of semi-volatile organic species (SVOCs). The presence of known carcinogenic PAHs on PEPs raises public health concerns and warrants further toxicological assessment.
The Spanish Civil War: From Revolutionary Insurrection to Popular Front

The impact of the revolutionary insurrection was profound. In Asturias, the revolutionaries had seized control of most of a province, and a military campaign of more than two weeks was required to defeat them. From this point, polarization increased, and some historians have referred to the insurrection either as the “prelude to” or “first battle” of the eventual civil war. Nonetheless, the democratic Republic remained intact, and there was still opportunity to overcome, or at least palliate, the deepening polarization. Almost all the new polities established in Europe after 1919 featured multiparty systems, but the Spanish Republic was unique in producing three successive drastic shifts in government within less than five years, making continuity very difficult and encouraging radicalization. Yet more unique was the absence of any coherent hegemonic force of the sort that, for good or ill, resolved crises in other countries. The Republic was unable to produce any kind of viable majority coalition, a dominant nationalist movement, a major hegemonic party, or even a temporary authoritarian government capable of enforcing its will. For nearly a year, from October 1934 to September 1935, Spain was governed by a CEDA-Radical coalition. Whereas the initial biennium of 1931–33 had been a time of advanced, sometimes radical, reformism, the second phase under the Radicals in 1933–34 was a period of balanced administration from the center. The government that Lerroux led in the third phase from 1934 to 1935 was a center-right coalition that moved in a much more conservative direction, revising or canceling a number of the earlier reforms and abruptly reversing most of the limited agrarian reform. In one sense, this was a normal development in a representative political system in which different electoral results may lead to different policies, but according to the left, it was the beginning of “fascism.”
Modeling of SOI four-gate transistor (G4FET) using multidimensional spline interpolation method

Abstract A numerical multidimensional spline interpolation method for CAD implementation of silicon-on-insulator (SOI) four-gate transistors (G 4 FET) is presented in this paper. The model is generated using available data for wide range of biasing and geometric variation and an independent set of test data is then used to validate its predictive accuracy. The objective of this DC model is to determine the drain current as a function of multiple terminal voltages and device geometry. The method is shown to work very well when independent variables do not exceed the range of training data set used for the model development. Both n -channel and p -channel G 4 FET models have been developed and validated using TCAD and experimental data. Moreover, models of both devices have been implemented in circuit simulator for simulating experimentally demonstrated innovative G 4 FET circuit.
Complete reversal of moderate/severe brain MRI abnormalities in a patient with classical phenylketonuria.

Abnormalities on magnetic resonance imaging (MRI) of the brain are common in older patients with phenylketonuria (PKU; McKusick 261600) (Cleary et al 1994). We, and others, have previously demonstrated that these changes are partially reversible following an improvement in biochemical control (Bick et al 1993; Cleary et al 1995). We now report a patient with classical PKU in whom MRI abnormalities completely resolved following a strict low-phenylalanine (phe) diet.
Epileptic Syndromes and Diseases

The work and proposals regarding classification and terminology of epilepsy syndromes published by the last two committees nominated by the International League Against Epilepsy (ILAE) are considered in this article.
Pulmonary hypertension: the great leveler.

Until recently, the diagnosis of pulmonary arterial hypertension (PAH) heralded a uniformly poor prognosis. However, improvement in quality of life and survival has ensued on the backbone of development of carefully targeted therapeutics ([1,2][1]). A similar recognition that the development of
Genetics and epigenetics of pediatric leukemia in the era of precision medicine

Pediatric leukemia represents a heterogeneous group of diseases characterized by germline and somatic mutations that manifest within the context of disturbances in the epigenetic machinery and genetic regulation. Advances in genomic medicine have allowed finer resolution of genetic and epigenetic strategies that can be effectively used to risk-stratify patients and identify novel targets for therapy. This review discusses the genetic and epigenetic mechanisms of leukemogenesis, particularly as it relates to acute lymphocytic leukemias, the mechanisms of epigenetic control of leukemogenesis, namely DNA methylation, histone modifications, microRNAs, and LINE-1 retroelements, and highlights opportunities for precision medicine therapeutics in further guiding disease management. Future efforts to broaden the integration of advances in genomic and epigenomic science into the practice of pediatric oncology will not only identify novel therapeutic strategies to improve clinical outcomes but also improve the quality of life for this unique patient population. Recent findings in precision therapeutics of acute lymphocytic leukemias over the past three years, along with some provocative areas of epigenetics research, are reviewed here.
Gas labyrinth seals: On the effect of clearance and operating conditions on wall friction factors – A CFD investigation

Abstract This paper presents a computational fluid dynamic (CFD) investigation quantifying the effects of labyrinth seal geometry and operating conditions on the rotor and stator circumferential friction factors (frθ, fsθ). These are needed to improve bulk-flow model (BFM) predictions of the evolution of circumferential flow velocity and the seal force coefficients. For a typical labyrinth seal tested by Vannini et al. (2014), the rotor frθ is independent of changes in clearance (0.8–2 × Cr) or the inlet preswirl ratio (αinlet = 0–0.72); whereas an increase in rotor speed (RΩ = 58–173 m/s) or outlet/inlet pressure ratio (PR = Pout/Pin = 0.40–0.85) decreases frθ. On the other hand, an increase in Ω, PR, and αinlet decrease the stator fsθ. Besides, fsθ increases with Cr. Predictions show that frθ and fsθ are mainly sensitive to PR, not to the magnitude of supply and discharge pressures.
The Graduate Course in Pedagogy: Survey of Instructors of College Pedagogy in the United States and Canada

Although numerous universities offer graduate students opportunities to develop their teaching, few studies probe the credit-bearing graduate course in college teaching. A survey of 105 instructors...
Examining the Recruitment, Placement, and Career Trajectories of Secondary Mathematics Teachers Prepared for High-Need Schools:

BackgroundSchool leaders are challenged by the relatively limited supply and high turnover of qualified secondary school mathematics teachers. In response, policy makers and teacher educators have ...
MECHANISMS OF BRAIN REJUVENATION

A growing body of work has shown that systemic manipulations, such as heterochronic parabiosis and young blood administration, can partially reverse age-related cellular impairments and loss of cognitive faculties in the aged brain. These studies have revealed an age-dependent bi-directionality in the influence of the systemic environment indicating anti-aging factors in young blood elicit rejuvenation while pro-aging factors in old blood drive aging. It has been proposed that introducing anti-aging factors or mitigating the effect of pro-aging factors may provide effective strategies to rejuvenate aging phenotypes. Despite this potential, much is unknown as to the systemic and molecular mechanisms regulating anti-aging and pro-aging effects of blood-borne factors. I will discuss work from my research group that begins to provide mechanistic insight into the systemic and molecular drivers promoting rejuvenation in the aging brain.
Primary and Secondary Prevention of Youth Suicide

Youth suicide is a national and global public health crisis. Pediatricians can use primary and secondary prevention strategies to intervene with youth before or after the onset of suicidal behaviors. Universal suicide risk screening programs can be used to identify youth in medical settings who may otherwise pass through the health care setting with undetected suicide risk. Pediatricians are uniquely positioned to help foster resilience in their young patients and equip families of at-risk youth with safety plans and lethal means safety counseling. Pediatricians on the frontlines of this critical public health crisis require education and training in detecting suicide risk, managing those who screen positive, and connecting their patients to much needed mental health interventions and treatments. Evidence-based suicide risk screening and assessment tools, paired with interventions, are feasible and potentially life-saving in the medical setting.
Evaluation of a Circumferential Extending Antagonist Actuator in a Soft Arm

This paper presents a novel circumferential pneumatic actuator to be used as an antagonist in soft bending arms. The design is based on a McKibben actuator, and the circular shape is inspired by octopus musculature. The performance of the presented actuator is evaluated through characterization of individual actuators, as well as experimental analysis of the actuator’s effect on the behavior of an existing soft bending arm segment. A stack of 16 circumferential actuators is capable of producing a force of 37 N when pressurized to 32 kPa and deflected to -15% strain. When the actuators are integrated into a 75 mm diameter soft arm, the arm is able to successfully lift 600 g (285% of its own mass) to 54% of the arm’s original height, which is 2.2 times the maximum load for the arm without antagonistic actuators. When the soft arm with antagonistic actuators lifted 250 g at 40 kPa, the segment returned to 101% of its original height, compared to 59% for the arm segment without antagonistic actuators. Compared to existing antagonistic systems, this circumferential actuator produces high extension strokes and high forces at pressures below 100 kPa. The presented actuator is simple to manufacture and the design is complementary to the geometry of many soft arms, which makes the actuator a suitable choice to improve the arms’ maximum load.
Optimal planning of progressively Type-I censored step-stress accelerated life test under interval inspection

For highly reliable products and devices, conducting the life tests at normal usage conditions demands a great deal of time and cost, which can result in missed opportunities to introduce the produ...
Leveraging Technology to Reduce Literacy Barriers on Social Health Screening Tools: Implications for Human Service Professionals and Administrators

Human service professionals help people develop skills to become self-sufficient and optimally function. To do so, social health screening tools help in understanding clients’ needs; however, discr...
Anti-plane shear waves in periodic elastic composites: band structure and anomalous wave refraction

For anti-plane shear waves in periodic elastic composites, it is shown that negative energy refraction can be accompanied by positive phase-velocity refraction and positive energy refraction can be accompanied by negative phase-velocity refraction , and that this can happen over a broad range of frequencies. Hence, in general, negative refraction does not necessarily require antiparallel group and phase-velocity vectors. Details are given for layered composites and the results are extended to, and illustrated for, two-dimensional periodic composites, revealing a wealth of information about the refractive characteristics of this class of composites. The composite's unit cell may consist of any number of constituents of any variable mass density and elastic modulus, admitting large discontinuities . A powerful variational-based solution method is used that applies to one-, two- and three-dimensional composites, irrespective of their constituents being homogeneous or heterogeneous. The calculations are direct, accurate and efficient, yielding the band structure, group-velocity, energy-flux and phase-velocity vectors as functions of the frequency and wavevector components, over an entire frequency band.
Local criteria for universal and primitively universal quadratic forms

Abstract In this paper, we provide criteria to determine whether a given integral quadratic lattice over a ring Z p of p-adic integers is Z p -universal or primitively Z p -universal. The criteria are stated explicitly in terms of a Jordan splitting of the lattice. As an application of the local criteria, we complete the determination of the universal positive definite classically integral quaternary quadratic forms that are almost primitively universal.
Ventricular tachycardia with epicardial and pericardial fibrosis 6 months after resolution of subclinical COVID-19: a case report

Coronavirus disease 2019 (COVID-19) has been shown to have extensive effects on the cardiovascular system. Its long-term cardiac manifestations, however, remain unclear. We report the case of a Caucasian patient with a mild and self-limited presentation of COVID-19, with subsequent development, months later, of exertional dyspnea and non-sustained ventricular tachycardia, long after resolution of his illness and after returning to aerobic exercise. The patient had normal screening tests including electrocardiogram (ECG) and echocardiogram 4 months after his illness. Cardiac magnetic resonance imaging demonstrated epicardial and pericardial fibrosis of the right ventricle free wall and outflow tract and the pericardium over the anterior wall, 6 months following the initial infection. First abnormal ECG was recorded at month 7 following illness. This case suggests an insidious and possible long-term cardiac involvement and reflects the challenges in traditional workups and screening modalities in identifying cardiac involvement in COVID-19.
Thermal Mapping of Metal Casting Mold Using High-Resolution Distributed Fiber-Optic Sensors

This article reports a technique to embed optical fiber into a copper mold plate for generating high-density thermal maps of the mold during the process of metal casting. The temperature measurements were based on acquiring and interpreting Rayleigh backscattering (RBS) signals from embedded fiber, using the interrogation technique of optical frequency domain reflectometry (OFDR). The instrumented mold plate was used to perform a cast-iron dip test and a steel dip test in a 200 lb induction furnace. The maximum temperatures recorded by the embedded fiber-optic sensors were 469 °C and 388 °C in the cast-iron and steel dip tests, respectively. The closely spaced and rapidly fluctuating temperature features that were imparted to the mold wall during solidification were successfully mapped with a high spatial resolution (0.65 mm) and a fast measurement rate (25 Hz) using a commercial OFDR interrogator (LUNA ODiSI 6108). Moreover, the thickness of the solidified steel shell was measured, and a thickness map of the shell was generated. A good correlation was observed between the thickness of the solidified shell and the temperature of the mold, as regions with higher and lower temperatures in the thermal profile of the mold corresponded to thicker and thinner areas on the shell, respectively. The dip testing experiments demonstrate that RBS-based fiber-optic sensing is a feasible and effective method for generating information-rich thermal maps of caster molds. The information obtained from thermal maps can be useful for improving the quality of the metal and productivity of the metal casting process.
Characterization of bone marrow CD4 to CD8 ratios and lymphocyte composition in adults by image analysis

Bone marrow (BM) lymphocyte subsets are evaluated by flow cytometry or immunohistochemistry for diagnostic purposes; however, CD4:CD8 T lymphocyte ratios are often erroneously interpreted using peripheral blood ranges. There are few and no recent studies describing the composition of lymphocytes within the marrow space, or normal reference ranges. Lymphocyte subsets in cytopenic patients and hospital autopsy BM specimens were evaluated to better characterize CD4:CD8 ratios. Ten patients with a history of cytopenia were identified from 2017 to 2021. Clinical history, cytogenetic testing, and results of a next generation sequencing panel were reviewed to rule out hematolymphoid disease. Thirty-five decedents who underwent a hospital autopsy from 2018 to 2019 were identified. History of hematolymphoid disease was ruled out by chart review. Immunohistochemical staining for CD3, CD20, CD4, and CD8 was evaluated with digital image analysis. Findings were compared to peripheral blood flow cytometry in a group of 20 living patients. BM CD4:CD8 ratios by image analysis were significantly lower than peripheral blood, mean in cytopenic patients 0.37:1 and mean in decedents 0.51:1 versus 2.6:1 (p = 0.99). Lymphoid aggregates were encountered with increasing frequency in older individuals. These findings aid in the evaluation of BM lymphocyte subsets and distribution both in living patients and autopsy evaluation. We also present a practical approach to image analysis.
Subjectivity and Subjugation in Seventeenth-Century Drama and Prose: The Family Romance of French Classicism

This 1992 book analyses the relation between an emergent modern subjectivity in seventeenth-century French literature, particularly in dramatic works, and the contemporaneous evolution of the absolutist state. It shows how major writers of the Classical period (Corneille, Racine, Moliere, Lafayette) elaborate a new subject in and through their representations of the family, and argues that the family serves as the mediating locus of a patriarchal ideology of sexual and political containment. Most importantly, it asks why the theatre became the privileged form of representation in this state, and why this theatre concentrates almost exclusively on family conflict. Professor Greenberg argues that the narrative of oedipal sexuality and subjugation central to this new literary canon reflected the conflicting social, political and economic forces that were shifting European society away from the universe of the Renaissance and guiding it towards the 'transparency' of Classical representation.
Reflective Thinking - a Guide to Paradigm Shifting in Rn -bsn Nursing Students

Engaging RN to BSN students in a paradigm shift by allowing them to retain pride in their basic nurse education while equipping them to reflect upon their practice as they collaborate with colleagues, mobilize and manage groups of co-workers, and strategize how to meet best practice goals is an overall aim of the RN to BSN program at Washington State University College of Nursing. Ethical comportment, as identified by Benner encompasses nursing practice identity, character, skilled know-how and self knowledge. Ethical comportment becomes the pathway to accomplish the paradigm shift goal. Students are introduced to reflective thinking through the use of case based dilemmas in an ethics course. Reflective thinking, in discussion groups with others, allows group members to understand the situation better instead of simply articulating standard ethical rules. Such thinking allows students to exercise their own clinical judgment and, at the same time, to critique their own practice. This approach has been used successfully in both in-class and online sections of the course. Students report a heightened sense of control as change agents when dealing with complex workplace and/or best practice issues by using reflective thinking in these situations.
A rocking bed respirator for use with premature infants in incubators; description of apparatus.

Summary An apparatus has been constructed for applying the rocking bed method of resuscitation or artificial respiration to premature infants within the Isolette incubator.
Integral Equations and Applications

The goal of this Section is to formulate some of the basic results on the theory of integral equations and mention some of its applications. The literature of this subject is very large. Proofs are not given due to the space restriction. The results are taken from the works mentioned in the references.
CMCC Metadata Agreement

This technical report describes the CMCC Metadata Agreement; the aim of the schema is to classify the CMCC data production (input, intermediate data and output of the experiments), models, services, etc. The CMCC Metadata Agreement complies with the ISO 19115 standard for Geographic Information. Metadata entities and code lists are fully described in this technical report.
Shift-Map based stereo image retargeting with disparity adjustment

This paper introduces a novel image retargeting algorithm for 3D images given as pairs of stereo images. In the context of 3D image retargeting, the novel viewpoint advocated in this paper is that the geometric consistency in the form of preserving disparity values should not be an overpowering objective formulated as hard constraints. Instead, for maximizing viewing experience and comfort, it is desirable to simultaneously retarget the images as well as adjust the disparity values. The proposed retargeting algorithm is based on the methods of shift-map and importance filtering, and the main technical contribution of this paper is a successful extension of these earlier techniques to 3D images. We have evaluated the proposed method extensively, and the results demonstrate the efficiency of the proposed method as well as its potential for producing high-quality outputs. In particular, comparing with the state-of-the-art, the proposed method has a considerably shorter running time, and at the same time, it produces the retargeted 3D images that are more agreeable and pleasing for viewing.
Correspondence re: S. E. Blutt, T. C. Polek, L. V. Stewart, M. W. Kattan, and N. L. Weigel, A calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice. Cancer Res., 60: 779-782, 2000.

We read with interest the report by Blutt et al. [(1)][1] , demonstrating inhibition of the growth of LNCaP prostate cancer cells in vivo by the calcitriol analogue, EB1089. We reported previously significant inhibitory effects of EB1089 on the proliferation of prostate cancer cells in vivo in the
Most smooth closed space curves contain approximate solutions of the n -body problem

The determination of the exact trajectories of mutually interacting masses (the n-body problem1,2) is apparently intractable for n ⩾ 3, when the generic solutions become chaotic. A few special solutions are known, which require the masses to be in certain initial positions; these are known as ‘central configurations’ (refs 1,2,3,4,5,6) (an example is the equilateral triangle formed by the Sun, Jupiter and Trojan asteroids). The configurations are usually found by symmetry arguments. Here I report a generalization of the central-configuration approach which leads to large continuous families of approximate solutions. I consider the uniform motion of equidistributed masses on closed space curves, in the limit when the number of particles tends to infinity. In this situation, the gravitational force on each particle is proportional to the local curvature, and may be calculated using an integral closely related to the Biot–Savart integral. Approximate solutions are possible for certain (constant) values of the particle speed, determined by equating this integral to the mass times the centrifugal acceleration. Most smooth, closed space curves contain such approximate solutions, because only the local curvature is involved. Moreover, the theory also holds for sets of closed curves, allowing approximate solutions for knotted and linked configurations.
Root characteristics of C4 grasses limit reliance on deep soil water in tallgrass prairie

C4 grass species in the mesic tallgrass prairie of central North America can exhibit both high root production and deep rooting in the soil profile (>2 m). Differences in root growth and the types of roots produced vary according to local environmental gradients and management practices. The production of deep roots in tallgrass prairie has been historically presumed as a mechanism for water uptake when surface soils are dry. We examined changes in root biomass, total root length, root width, and theoretical hydraulic conductivity using roots collected from deep soil cores in upland and lowland topographic positions in grazed and ungrazed watersheds of the Konza Prairie Biological Station in north-eastern Kansas, USA. Root biomass, total root length, and theoretical hydraulic conductivity were highest in roots found in the top 20 cm of the soil profile, and then declined exponentially with increasing soil depth. Compared to grazed areas, ungrazed locations had more root biomass and total root length of roots in the most superficial soil layers. No differences in rooting profiles were present among topographic contrasts. Theoretical hydraulic conductivity of axial root xylem did not vary by topographic position or grazing contrasts, and declines in conductivity by depth were driven by changes in the number of vessels per stele, rather than changes in vessel size. Irrespective of differences by grazing treatment or topographic position, significant reductions in root biomass, total root length, and theoretical hydraulic conductivity of grass roots at soil depths greater than 1 m suggest deep roots in this grassland have limited functional significance for water uptake.
Residential refrigerators: Energy conservation and economics

Abstract A detailed computer model is developed to calculate energy flows and electricity uses for residential refrigerators. The model is used to evaluate the energy and associated initial cost impacts of alternative designs to reduce refrigerator energy use. Implementing all the changes considered, except for elimination of the frost-free feature, would cut electricity use 52% and increase purchase price only 19%.
Predictive fuzzy expert controllers

Abstract Fuzzy control is an effort to mimic the thinking process of human operators. This paper overviews the current fuzzy control techniques from industrial engineering point of view. The emphasis is to introduce the concept of adaptability to industrial fuzzy controllers. This need is obvious. If fuzzy controllers are expected to be successful in industrial environments, then they should adapt themselves to inevitable changing operating conditioins as well as human operators do. This paper presents a new technique in which the knowledge of a fuzzy controller is updated to reflect the changing process and environmental conditions.
Effects of Excess Degradable Protein on Postpartum Reproduction and Energy Balance in Dairy Cattle

The objectives of this study were to observe endocrine and reproductive responses of cows and heifers fed two diets (16 and 19% CP), which met undegradable protein requirements but differed in rumen degradable protein. Cows (n = 33) and heifers (n = 32) were randomly assigned within parity to diets at calving and remained on diets for 20 d after first breeding. Energy balance was determined twice weekly through the first luteal phase. Blood and milk samples were taken three times per week. Diet did not affect average daily energy balance, days to negative energy balance nadir, days to first ovulation, days to first service, or plasma glucose concentrations. First service conception rate was lower (31% vs. 48%) and plasma urea higher in animals fed the high protein diet. Days to energy balance nadir was correlated with days (r = .75) to first ovulation. Luteinizing hormone pulse frequency increased and pulse amplitude decreased in frequent samples (12-min intervals for 8 h) collected at 14 d postpartum versus sampling after the energy balance nadir. These data suggest that energy balance status plays an important role in determining the postpartum return of cyclic ovarian activity. Feeding excess CP as rumen degradable protein elevated plasma urea concentrations and decreased first service conception rate.
Microbiological Testing in the Diagnosis of Periodontal Disease

The oral microbiota plays a primary role in the initiation and progression of the most common forms of periodontal disease. Because of the multiplicity of factors that control the establishment and long-term evolution of the oral microbiota, a great deal of heterogeneity exists in the composition of the periodontal microbiota among individual subjects. Despite these individual differences and the complex interactions between bacteria and the host and among bacteria, an association has been demonstrated between certain species and various forms of periodontal disease. However, the predictive value of either positive or negative tests for selected bacterial species has not proved to be high enough for routine use in clinical practice. Nevertheless, bacteriological tests have been of value in the management of patients with juvenile periodontitis and refractory forms of periodontal disease. The increasing availability of diagnostic laboratory services and diagnostic kits for office use will make it easier for the practitioner to select appropriate antimicrobial treatments and monitor patients undergoing antimicrobial therapy.
Effect of gamma irradiation on pigs fed low vitamin A rations.

Summary1. Pigs irradiated with 350 r bilaterally at the rate of 11 r per minute 9 feet from source survived an average of 254 hours. 2. A moderate Vit. A deficiency had no effect on irradiation damage; in fact, the Vit. A low pigs lived an average of 2 days longer. 3. Pigs fed low levels of Vit. A and with very low liver and blood Vit. A levels showed no gross manifestations of a deficiency of Vit. A. Feed intake and growth rate were fairly normal. 4. Irradiation lowered the total white blood cell count rapidly. 5. The major symptoms of irradiation damage were: (a) depression, (b) skin hemorrhages, (c) hemorrhaging from eyes and mouth, (d) increased respiration, (e) mild muscular spasms just prior to death, (f) extensive hemorrhage of lymph nodes plus varying amounts of hemorrhage in the kidneys, heart, urinary bladder, intestine and stomach.