cssi/SciSciGPT-SciSciNet huggingface dataset:
A Cell-Surface Receptor for Lipocalin 24p3 Selectively Mediates Apoptosis and Iron Uptake

The lipocalin mouse 24p3 has been implicated in diverse physiological processes, including apoptosis due to interleukin-3 (IL-3) deprivation and iron transport. Here we report cloning of the 24p3 cell-surface receptor (24p3R). Ectopic 24p3R expression confers on cells the ability to undergo either iron uptake or apoptosis, dependent upon the iron content of the ligand: Iron-loaded 24p3 increases intracellular iron concentration without promoting apoptosis; iron-lacking 24p3 decreases intracellular iron levels, which induces expression of the proapoptotic protein Bim, resulting in apoptosis. Intracellular iron delivery blocks Bim induction and suppresses apoptosis due to 24p3 addition or IL-3 deprivation. We find, unexpectedly, that the BCR-ABL oncoprotein activates expression of 24p3 and represses 24p3R expression, rendering BCR-ABL(+) cells refractory to secreted 24p3. By inhibiting BCR-ABL, imatinib induces 24p3R expression and, consequently, apoptosis. Our results reveal an unanticipated role for intracellular iron regulation in an apoptotic pathway relevant to BCR-ABL-induced myeloproliferative disease and its treatment.
Airway regional anesthesia for awake fiberoptic intubation

Providing anesthetic care to the patient with a difficult airway keenly interests anesthesiologists and is a situation that often provokes much anxiety and trepidation. However, dealing effectively and safely with these patients is a skill that all anesthesiologists should be familiar with and are expected to perform with competency. Difficult airways arise from multiple causes. Access to the oral cavity can be impeded by unfavorable anatomy, such as a small mouth or receding jaw, as well as reduced mouth opening due to radiation therapy, jaw fracture, or previous head and neck surgery. Difficulty in neck extension shows up in the patient who can’t extend due to prior cervical fusion or advanced osteoarthritis. In addition, neck extension is contraindicated in patients with unstable cervical spines due to fractures, rheumatoid arthritis, Down syndrome, etc. Finally, there is a subset of patients who cannot be intubated using direct laryngoscopy due to anatomical variations, even though their airway exam appears normal.
The Molecular Basis of Self-Avoidance

Self-avoidance, the tendency of neurites of the same cell to selectively avoid each other, is a property of both vertebrate and invertebrate neurons. In Drosophila, self-avoidance is mediated by a large family of cell recognition molecules of the immunoglobulin superfamily encoded, via alternative splicing, by the Dscam1 locus. Dscam1 promotes self-avoidance in dendrites, axons, and prospective postsynaptic elements. Expression analysis suggests that each neuron expresses a unique combination of isoforms. Identical isoforms on sister neurites exhibit isoform-specific homophilic recognition and elicit repulsion between processes, thereby promoting self-avoidance. Although any isoform can promote self-avoidance, thousands are necessary to ensure that neurites readily discriminate between self and nonself. Recent studies indicate that a large family of cadherins in the mouse, i.e., the clustered protocadherins, functions in an analogous fashion to promote self-avoidance. These studies argue for the evolution of a common molecular strategy for self-avoidance.
Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane

Although the transport of model proteins across the mammalian ER can be reconstituted with purified Sec61p complex, TRAM, and signal recognition particle receptor, some substrates, such as the prion protein (PrP), are inefficiently or improperly translocated using only these components. Here, we purify a factor needed for proper translocation of PrP and identify it as the translocon-associated protein (TRAP) complex. Surprisingly, TRAP also stimulates vectorial transport of many, but not all, other substrates in a manner influenced by their signal sequences. Comparative analyses of several natural signal sequences suggest that a dependence on TRAP for translocation is not due to any single physical parameter, such as hydrophobicity of the signal sequence. Instead, a functional property of the signal, efficiency of its post-targeting role in initiating substrate translocation, correlates inversely with TRAP dependence. Thus, maximal translocation independent of TRAP can only be achieved with a signal sequence, such as the one from prolactin, whose strong interaction with the translocon mediates translocon gating shortly after targeting. These results identify the TRAP complex as a functional component of the translocon and demonstrate that it acts in a substrate-specific manner to facilitate the initiation of protein translocation.
Aerodynamics of dragonfly flight and robotic design

A pair of dynamically scaled robotic dragonfly model wings was developed to investigate the aerodynamic effect of wing-wing interaction in dragonfly flight. Instantaneous aerodynamic forces were measured while forewing-hindwing phase difference (γ) was systematically varied. Experimental results showed that, i) for hovering flight, γ=0° enhanced the lift force on both forewing and hindwing; γ=180° reduced the total lift force, but was beneficial for vibration suppression and body posture stabilization. In nature, 0° is employed by dragonflies in acceleration mode while 180° is usually in hovering mode. ii) For forward flight, wing-wing interaction enhances forewing lift while reduced hindwing lift at all phase differences. Furthermore, the total lift was slightly reduced for γ= 0° to 90° and significantly reduced by 18% when γ=270°. The results consist well with the fact that, dragonflies usually employ 50° to 100° for forward flight, but seldom employ 270°. PIV results are shown for wing-wing interaction analysis.
Trail-Following Behavior of Coptotermes formosanus and Reticulitermes flavipes (Isoptera: Rhinotermitidae): Is There a Species-Specific Response?

Bioassays were conducted to examine the response of Coptotermes formosanus Shiraki and Reticulitermes flavipes (Kollar) to whole body extracts of termites. Bioassays were also conducted to determine if trail-following behavior could be elicited in glass tubes after different lengths of exposure to termites and if termites showed any species-specific response to exposed tubes. Trail-following behavior was elicited in both species in response to whole body extracts of their nestmates. Although C. formosanus responded to the R. flavipes extract, R. flavipes did not show a difference in response to the C. formosanus extract versus solvent-treated controls. Trail-following behavior was elicited in both C. formosanus and R. flavipes by glass tubes exposed to termites for 5 min. Although neither species showed a preference for glass tubes exposed to their nestmates over tubes exposed to termites of the other species, there were differences in the persistency of trail-following substances deposited in tubes by the two species. When tubes were exposed to termites for 5 min, trail-following behavior was elicited by tubes exposed to C. formosanus for at least 1 h after exposure, whereas termites no longer responded to tubes that were exposed to R. flavipes 10–15 min after exposure. When tubes were exposed to termites for 14 d, termites deposited chemical markers which lasted for at least 8 d. There was no difference in the response of C. formosanus to tubes exposed to their nestmates versus tubes exposed to R. flavipes. However, R. flavipes showed a significant preference for tubes exposed to their nestmates over tubes exposed to C. formosanus. Because there was no evidence of a species-specific response by R. flavipes to tubes exposed to termites for only 5 min, it is possible that chemicals in the feces or in salivary secretions deposited in tubes influenced the behavior of R. flavipes in tests using tubes exposed to termites for 14 d.
Short- and long-term reproducibility of marrow adipose tissue quantification by 1H-MR spectroscopy

To assess short- and long-term reproducibility of marrow adipose tissue (MAT) quantification by 1H-MR spectroscopy. Our study was IRB-approved and HIPAA compliant. Written informed consent was obtained. We studied 20 overweight/obese but otherwise healthy subjects (12 female, 8 male) with a mean age of 37 ± 6 years. All subjects underwent proton magnetic resonance spectroscopy (1H-MRS) of the fourth lumbar vertebral body using a single-voxel point-resolved spatially localized spectroscopy sequence without water suppression at 3 T. Measurements were repeated after 6 weeks and 6 months using identical scanning protocols. The following clinical parameters were collected, weight, BMI, exercise status, and trabecular bone mineral density (BMD), by quantitative computed tomography. Short- (baseline, 6 weeks) and long-term (baseline, 6 months) reproducibility of MAT was assessed by the coefficient of variance (CV), standard deviation (SD), and interclass correlation coefficients (ICCs). Short- and long-term changes in clinical parameters were assessed by paired t-test. For short-term reproducibility between baseline and 6-week scans, the CV was 9.9 %, SD was 0.08, and ICC was 0.97 (95 % CI 0.94–099). For long-term reproducibility between baseline and 6-month scans, the CV was 12.0 %, SD was 0.10, and ICC was 0.95 (95 % CI 0.88 to 0.98). There was no significant short- or long-term change in clinical parameters (weight, BMI, exercise status, BMD) (p > 0.2). 1H-MRS is a reproducible method for short- and long-term quantification of MAT. Our results can guide sample size calculations for interventional and longitudinal studies.
The Annual Water Balance

The average annual one-dimensional water balance is expressed for natural surfaces in terms of physically-significant dimensionless parameters. This provides the basis for dynamic similarity of the water balance and for an improved understanding of climate-soil-vegetation coupling. A sensitivity analysis points out the critical importance of the potential rate of evapotranspiration in defining water balance variations due to changes in other climate and soil parameters. A first-order analysis of the average annual water balance gives an equation for the annual water balance that can be used to estimate the cumulative distribution functions (cdf) of the components of the annual water balance in terms of the cdf of the annual precipitation and of observable parameters of the physical system. This provides a rational basis for assessing the risk due to physical changes in the land surface and for estimating the recurrence interval of such water balance components as basin yield.
Aedes Minervae in Foro Boario.

In this article the Autor advances a new interpretation for the archaic temple discovered beneath the twin shrines of Fortuna and Mater Matuta in the Forum Boarium. Analysing Colini’s (the excavator’s) interpretation by which this temple is assumed to be a temple of Mater Matuta, he shows us how this assumption is based in scanty and indirect evidence. Even so, it is accepted by specialists as a real dogma. Comparing the statuary group connected with the second phase of the archaic temple with a recently restored terracotta statue group from Portonaccio Sanctuary at Veii, the Autor arrives at a very different conclusion. As a matter of fact, he is able to demonstrate that this archaic temple in Forum Boarium is in reality an “Aedes Minervae” and not Mater M atuta’s temple as is usually assumed.
Prevalence of frequent fighting among youth: a cross-national comparison of 39 countries

Background Existing youth violence research lacks an understanding of youth who engage in frequent physical fighting (>12 times per year). Objective Using nationally representative samples of youth, this study examined the prevalence of 'frequent fighting' across 39 countries. Methods Analyses were based on the Global School-based Student Health Survey of school-attending youth supported by the WHO and the CDC. US data from the Youth Risk Behaviour Survey were included for comparison. The surveys were conducted between 2003 and 2009 and each country dataset included more than 1000 students and was weighted to be nationally representative. Countries were categorised into the following regions: Africa, the Americas, Europe, the Eastern Mediterranean, South East Asia, and the Western Pacific. One-way ANOVA was used to determine regional differences in frequent fighting prevalence. Results Among the 39 countries used in analyses, the prevalence of frequent fighting was highest in Tunisia (8.4%) and lowest in Myanmar (0.5%). One-way ANOVA and post hoc testing determined that the prevalence of frequent fighting varies significantly by region (F(2, 28)=4.12, p Significance The prevalence of frequent fighting varied substantially across the 39 countries examined. More cross-national research is needed to better understand the context of frequent fighting and to inform youth violence prevention efforts. This is an abstract of a presentation at Safety 2012, the 11th World Conference on Injury Prevention and Safety Promotion, 1-4 October 2012, Michael Fowler Center, Wellington, New Zealand. Full text does not seem to be available for this abstract.
The continued influence of implied and explicitly stated misinformation in news reports

The piecemeal reporting of unfolding news events can lead to the reporting of mistaken information (or misinformation) about the cause of the newsworthy event, which later needs to be corrected. Studies of the continued influence effect have shown, however, that corrections are not entirely effective in reversing the effects of initial misinformation. Instead, participants continue to rely on the discredited misinformation when asked to draw inferences and make judgments about the news story. Most prior studies have employed misinformation that explicitly states the likely cause of an outcome. However, news stories do not always provide misinformation explicitly, but instead merely imply that something or someone might be the cause of an adverse outcome. Two experiments employing both direct and indirect measures of misinformation reliance were conducted to assess whether implied misinformation is more resistant to correction than explicitly stated misinformation. The results supported this prediction. Experiment 1 showed that corrections reduced misinformation reliance in both the explicit and implied conditions, but the correction was much less effective following implied misinformation. Experiment 2 showed that implied misinformation was more resistant to correction than explicit misinformation, even when the correction was paired with an alternative explanation. Finally, Experiment 3 showed that greater resistance to correction in the implied misinformation condition did not reflect greater disbelief in the correction. Potential reasons why implied misinformation is more difficult to correct than explicitly provided misinformation are discussed.
A 0.25-to-2.25 GHz, 27 dBm IIP3, 16-Path Tunable Bandpass Filter

A fully-differential, 16-path bandpass filter (BPF) is demonstrated with wide tuning range, high linearity for and wideband harmonic rejection. The reconfigurable filter and clock generation circuitry is fabricated in IBM 45 nm CMOS SOI. To cover a tuning range of one decade (250 MHz to 2250 MHz), a 16-path scheme eliminates harmonic aliasing component to 15th harmonic of the local oscillator. The BPF has a 3 dB bandwidth greater than 20 MHz and 0.9 dB insertion loss. The BPF also achieves high linearity with an out-of-band IIP 3 > 27 dBm and P1dB > 3 dBm. The BPF tolerates blockers to 9 dBm 1 dB desensitization point (B1dB).
Serum immunoglobulins in multiple sclerosis patients.

Of the several hypotheses of the etiology of multiple sclerosis (MS), that of an autoimmune process has gained prominence (1, 2). However, attempts to demonstrate circulating antibodies in sera of MS patients against components of brain tissue have yielded negative results (3-5). A myelinolytic agent first thought to be specific for MS sera (6), has also been found in sera of patients with other neurologic diseases and even in those of normal controls (7). Seitelberger (8) recently attempted to reconcile experimental immunologic data and pathologic-anatomic findings in MS to arrive at a plausible hypothesis of its pathogenesis. He postulated a central nervous system (CNS) virus infection or other primary insult followed by entrance of CNS immunogenic proteins into the circulation with ensuing immunologic sequelae. Earlier, several authors had suggested a virus etiology (9, 10), and measles antibodies had been extensively studied in patients with MS (11, 12). Other carefully controlled virus studies (13) c...
Rapid Quantification of Juniperus Pollen Proves Overlapping Pollen Seasons

Rashmi Prava Mohanty, Mark A. Buchheim, PhD, Estelle Levetin, PhD, FAAAAI; University of Tulsa, Tulsa, OK, University of Tulsa. RATIONALE: Microscopic analysis of air samples fails to determine the pollination season overlap between various species with morphologically similar pollen such as members of the Cupressaceae and Poaceae. Previously, we showed it was possible to use PCR to identify Juniperus ashei pollen from air samples. The present study was undertaken to determine if qPCR could be used to determine airborne pollen counts for three Juniperus species and define the pollination season overlap. METHODS: The atmosphere in Tulsa, OK(USA) was monitored with a Burkard sampler and analyzed by microscopy using standard methods. A second Burkard sampler was used from 2013 to 2015 for molecular analysis; 109 samples were tested with species-specific primers and probes designed for J.ashei, J.pinchotii and J.virginiana. Numbers of pollen grains obtained from microscopy were compared with numbers obtained from qPCR by Spearman correlation coefficient. RESULTS: Cupressaceae pollen was detected in the Tulsa atmosphere from October through April. The qPCR counts for total Juniperus pollen showed a significant correlation with the microscope counts, R50.92, p<0.001. Quantitative PCR data showed overlapping pollen seasons. In the fall, data indicated five days (in two years) with both J.pinchotii and J.ashei pollen. Similarly, in January and February eight days (in two years) indicated both J.ashei and J.virginiana pollen in the air. CONCLUSIONS: This approach is a rapidmethod to identify and quantify specific pollen types and the pollen season overlap where species and genera cannot be distinguished by microscopy. Defining the exact pollination season will be a benefit for patients sensitive to pollen from specific taxa.
Comparison of 2-Ethyl-Cyanoacrylate and 2-Butyl-Cyanoacrylate for Use on the Calvaria of CD1 Mice

Short-chain cyanoacrylates (SCCA), such as ethyl-2-cyanoacrylate (KrazyGlue, Aron Alpha, Columbus, OH) are commonly used as commercial fast-acting glues. Although once used in clinical medicine as skin adhesives, these products caused tissue toxicity and thus their use in live tissue was discontinued. SCCA were replaced by longer-chain versions (LCCA), such as butyl-cyanoacrylate (Vetbond, 3M, St Paul, Minnesota), which were found to be less toxic than the short-chain formulations. Some researchers prefer to use SCCA due to the belief that they create a stronger bond than do the longer-chain counterparts. In survival surgeries, we compared the bone thickness, bone necrosis, fibrosis, inflammation, and bone regeneration in the calvaria of control (naive), surgery-only, SCCA-treated, and LCCA-treated mice (n = 20 per group). At 1 and 14 d after surgery, all mice except those treated with SCCA showed statistically similar bone measurements to those of the naive control group. The SCCA group had significantly less bone regeneration than did all other groups. These results suggest that the application of SCCA causes bone damage resulting in the loss of bone regeneration. This finding may assist investigators in choosing a tissue glue for their studies and may support the IACUC in advocating the use of pharmaceutical-grade tissue glues.
Mechanisms driving the soil organic matter decomposition response to nitrogen enrichment in grassland soils

Abstract Empirical studies show that nitrogen (N) addition often reduces microbial decomposition of soil organic matter (SOM) and carbon dioxide (CO2) production via microbial respiration. Although predictions from theoretical models support these findings, the mechanisms that drive this response remain unclear. To address this uncertainty, we sampled soils of three grassland sites in the U.S. Central Great Plains that each have received seven years of continuous experimental nutrient addition in the field. Nitrogen addition significantly decreased the decomposition rate of slowly cycling SOM and the cumulative carbon (C) respired per mass soil C. We evaluated whether this effect of N addition on microbial respiration resulted from: 1) increased microbial carbon use efficiency (CUE), 2) decreased microbial oxidative enzyme activity, or 3) decreased microbial biomass due to plant and/or soil mediated responses to N enrichment. In contrast to our hypotheses – as well as results from N addition studies in forest ecosystems and theoretical predictions – N did not increase microbial CUE or decrease microbial oxidative enzyme activity. Instead, reduced microbial biomass likely caused the decreased respiration in response to N enrichment. Identifying what factors drive this decreased microbial biomass response to N should be a priority for further inquiry.
The Pathetic Fallacy in Hellenistic Pastoral1

Thee, shepherd, thee the woods, and desert caves And all their echoes mourn.Milton, LycidasWebster's Third International Dictionary defines the ‘pathetic fallacy’ as ‘the ascription of human traits or feelings to inanimate nature.’ While this definition is in substance what John Ruskin meant when he first spoke of the pathetic fallacy more than a century ago, the great critic intended not merely to describe a movement in art, but to denounce that movement:All violent feelings … produce in us a falseness in all our impressions of external things, which I would generally characterize as the ‘Pathetic fallacy.’… The temperament which admits the pathetic fallacy, is … that of a mind or body in some sort too weak to deal fully with what is before them or upon them; borne away, or over-clouded, or over-dazzled by emotion …Ruskin rejected the pathetic fallacy when artists reduced it to a stock attribute of nature which neither they nor their public believed to reflect the truth. When, however, the pathetic fallacy did convey the artist's true feelings about nature — as groundless in reality as that feeling might have been — the artist was somehow less culpable: the truth of the sentiment mitigated the violation of empirical Truth.
Measuring dimensions of intergenerational contact: factor analysis of the Queen's University Scale.

ABSTRACTObjectives: Intergenerational contact has been linked to a range of health outcomes, including greater engagement and lower depression. Measures of contact are limited. Informed by Allport's contact theory, the Queen's University Scale consists of items rating contact with elders. We administered the survey to a young adult sample (N = 606) to identify factors that may optimize intervention programming and enhance young persons' health as they age.Methods: We conducted exploratory factor analysis (EFA) in the structural equation modeling framework and then confirmatory factor analysis with items pertaining to the general elder population.Results: EFAs did not yield an adequate factor structure. We tested two alternative confirmatory models based on findings from the EFA. Neither a second-order model nor a first-order model allowing double loadings and correlated errors proved adequate.Conclusion: Difficulty finding an adequate factor solution reflects challenges to measuring intergenerational cont...
The Role of Generic Language in the Early Development of Social Categorization.

Classifying people into categories not only helps humans simplify a complex social world but also contributes to stereotyping and discrimination. This research examines how social categorization develops by testing how language imbues with meaning otherwise arbitrary differences between people. Experimental studies (N = 129) with 2-year-olds showed that generic language—language that refers to abstract kinds—guides the development of social categorization. Toddlers learned a new category after hearing generic language about individuals who shared an arbitrary perceptual feature but not after hearing matched specific language, simple labels, or plural (but nongeneric) language about the same set of individuals. These findings show how subtle linguistic cues shape the development of social categorization.
The neighborhood school stigma: School choice, stratification, and shame:

Social scientists have begun to document the stratifying effects of over a decade of unprecedented charter growth in urban districts. An exodus of students from traditional neighborhood schools to ...
Convolving over time via recurrent connections for sequential weight sharing in neural networks

Convolutional Neural Networks (CNNs) have proven effective for machine learning tasks such as computer vision. Analog, asynchronous hardware implementations of such neural networks appear to be promising avenues for fast, online, real-time, energy efficient machine learning. However, the weight-sharing requirements of CNNs present challenges for such neuromorphic designs. We propose a biologically plausible method of implementing CNN weight sharing by convolving over time via recurrent synaptic connections. As a case study, we design a Recurrent Convolutional Neural Network (RCNN) for classification on the MNIST dataset. Our RCNN competes comparably with traditional CNN architectures while also providing significant area, storage, and connectivity advantages that qualify it for neuromorphic implementations capable of computing on analog and/or time-based signals.
A role for T helper cells in anti–CTLA-4 therapy

Comparison of immune responses to CTLA4 and PD-1 blockade uncovers a role for helper T cells in anti–CTLA-4 therapy.
Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK pathway mutations

Langerhans cell histiocytosis (LCH) is a disorder of myeloid neoplasia of dendritic cells that affects 1 in 200,000 children
Searching private data in a cloud encrypted domain

Cloud computing security and reliability are important challenges in the research agenda. For some applications managing sensitive data, cloud security solutions and data-privacy management are the main concerns for organizations that are considering a move to the cloud. The advantages of cloud computing include reduced costs, easy maintenance and re-provisioning of resources, thereby also possibly increasing profits. But the adoption of Cloud Computing solutions applies only if different security concerns are ensured. This article presents a solution for data storage and data management in Internet Storage Clouds, preserving privacy conditions under the control of Cloud users. The proposed solution supports operations over stored encrypted data, including reading, writing and searching based on relevance ranking and multiple keywords. The approach is based on a middleware architecture supported by homomorphic encryption techniques combined with dynamic indexing mechanisms. The solution preserves data-privacy without need to either decipher data during operations in the Cloud or transfer the data during searches. The article further describes an implementation prototype of the solution and its evaluation. The evaluation shows that the solution is viable, offers security and privacy control for the user and does not aggravate conditions of data-access latency and availability.
Patient-reported outcomes in cirrhosis: A scoping review of the literature.

Patients with cirrhosis seek improvement in their symptoms, functioning, quality of life, and satisfaction with the care they receive. However, these patient-reported outcomes (PROs) are not routinely measured for clinical care, research, or quality improvement. The members of the American Association for the Study of Liver Diseases Practice Metrics Committee, charged with developing quality indicators for clinical practice, performed a scoping review of PROs in cirrhosis. The aim is to synthesize a comprehensive set of PROs for inclusion into a standard patient-centered outcome set. We searched Medline, Embase, the Cumulative Index to Nursing and Allied Health Literature, PsycINFO, and the Cochrane Trial Library since inception, with final searches run between April 20 and June 1, 2017. Studies were included if they reported the construction and/or validation of a PRO instrument for patients with cirrhosis or if they assessed the clinical (case-mix) variables determining responses to established PRO scales. Eleven studies were selected that yielded 259 items specific to patients with cirrhosis. After removing duplicates, 152 unique items were isolated. These items were consolidated into seven domains: physical symptoms, physical function, mental health, general function, cognition, social life, and satisfaction with care. The seven domains included 52 subdomains (e.g., physical domain, abdominal pain subdomain). Twelve variables were identified that independently modified established PRO scales. These included clinical factors (severity of liver disease and its complications, medication burden, and comorbidities), specific PROs (cramps, pruritis), and surrogate outcome measures (falls, hospitalization). Conclusion This scoping review identified and categorized a large existing set of PRO concepts that matter to patients with cirrhosis; these outcomes may now be translated into usable measures both for the assessment of the quality of cirrhosis care in clinical practice and to perform research from the patient's perspective. (Hepatology 2018;67:2375-2383).
Wind in the sails or choppy seas?: People-place relations, aesthetics and public support for the United States’ first offshore wind project

Abstract The primary social challenge of offshore wind power development may be local community members’ struggle to come to terms with the transformation of the ocean. In this study of local residents’ perceptions of the first wind power project off the North American coast, we consider whether factors such as aesthetics and place attachment, dependency and identity might serve as barriers or gateways toward an offshore wind power future. Respondents are 420 coastal Rhode Island and Block Island residents who were randomly sampled by mail or internet prior to turbine installation and after project commissioning. Data were analysed using weighted descriptive statistics and multiple imputed regression analysis. 87% of respondents who live in census tracts bordering the coast support or lean toward supporting the project despite paying significantly above-market prices for the electricity generated. Regression models show that support for the project is influenced, at least in part, by general disposition toward wind power and whether a respondent likes the turbines’ appearance, with place-related measures having less influence. Descriptions of the wind turbines that resonated with supporters and opponents include respectively, “Symbolic of progress towards clean energy” and “Cause the loss of something intangible, where all you see is the ocean”.
What does Imprinting Mean? New Perspectives on Imprint Formation and Persistence Processes

One of the classic and foundational works in organizational theory is Stinchcombe's 1965 essay entitled Social Structure and Organizations. Stinchcombe (1965: 154) observes that organizations forme...
Methotrexate Update: Mechanism of Action in Psoriasis Therapy:

BackgroundLong before the advent of the biologic agents, methotrexate was the gold standard for the treatment of moderate to severe psoriasis. Although methotrexate's therapeutic efficacy in the tr...
Photoinduced Toxicity of Anthracene in Aquatic Organisms: an Environmental Perspective

Abstract The toxicity of anthracene, a common polycyclic aromatic hydrocarbon (PAH), has been assessed in a variety of aquatic organisms under environmentally realistic conditions. In the presence of natural or simulated sunlight anthracene was acutely toxic, at concentrations within aqueous solubility limits, to freshwater zooplankton, insect larvae, and fish. Less than 15 min was required for 50% immobilization of Daphnia pulex at 1 2 2 μg anthracene/l under natural sunlight (UV-B, 310 +/- 34 nm, = 484 μW/cm 2 ). Culicid mosquito larvae were also sensitive to anthracene phototoxicity with a 24 hr LC–50 value of 26.8 μg/l at a solar UV intensity five times less than summer maximum in Michigan. A 96 hr LC–50 value of 11.9 μg anthracene/l was determined for a natural population of juvenile bluegill sunfish at a solar UV intensity equivalent to a depth of 0.6 m in a typical eutrophic north-temperate lake. A freshwater green alga was not adversely affected by the light-anthracene combination. These findings are in contrast to the previously reported non-toxicity of anthracene to aquatic organisms. Evidence exists which suggests that anthracene is only one of many PAH that can cause photoenhanced toxicity, and concentrations of these compounds are expected to increase in surface waters as a result of increased use of fossil-fuel for heat and energy. The potential environmental consequences of increased loading of PAH in freshwater and marine systems are discussed. We conclude that solar UV radiation is an environmental parameter which must be accounted for when assessing the toxicity of PAH to aquatic organisms.
Geometric Algebra and Möbius Sphere Geometry as a Basis for Euclidean Invariant Theory

Physicists have traditionally described their systems by means of explicit parametrizations of all their possible individual configurations. This makes a local description of the motion of the system relatively simple, but provides little insight into the global properties of its solution space. Geometers, on the other hand, tend to describe their systems implicitly in terms of their invariant geometric properties. This approach has the substantial advantage of enabling them to deal with entire sets of configurations simultaneously, and renders every theorem global in scope. In physical problems, an analogous approach would use invariants of the Lie group underlying the dynamical system in question, e.g. angular momentum in the case of rotationally invariant dynamics.
Information Systems Education: What's missing?

We are doing a good job of teaching IS technology and project management but are omitting implementation planning. We need to teach our users and professionals how to answer the following critical questions for our mission-critical transaction processing applications (TPS).
Education and Occupations: Reexamining the Conventional Wisdom About Later First Births Among American Mothers

Using biannual Current Population Survey data, this paper reexamines the question of how education and occupations led to the postponement of first births among American mothers in the 1970s through 1990s. Analytical methods in earlier investigations predispose researchers to favor an “investment” model of education's effects, but an alternative method used in this analysis suggests that college attainment's major effect on age at first birth is primarily the result of years spent childless in college. Mothers-to-be in higher prestige occupations did delay motherhood longer than did those in other occupations. This study extends earlier research by examining whether or not conclusions drawn about all women (with and without children) apply to the majority of women—those who become mothers. The expansion of higher education, higher prestige occupations, and their impact on work and family decisions are discussed.
Community health workers, access to care, and service utilization among Florida Latinos: A randomized controlled trial

Objectives. To determine whether a 1-year community health worker intervention improves access to care and service utilization among Latinos with diabetes.Methods. We conducted a single-blind rando...
Current-Source Inverters for Integrated Motor Drives using Wide-Bandgap Power Switches

Integrated motor drives (IMDs) can deliver substantial economic benefits by replacing low-efficiency fixedspeed motors with compact adjustable-speed drives that combine the power electronics and motor into the same physical structure. IMDs are currently implemented using voltage-source inverters since this topology is naturally compatible with conventional silicon-based power devices. However, major advances in the development of new types of power semiconductor switches made from wide-bandgap (WBG) semiconductor materials such as silicon carbide and gallium nitride open intriguing opportunities for the development of reverse-voltage-blocking switches that are well-suited for use in current-source inverters (CSIs). These WBG power switches are capable of operating efficiently at high switching frequencies ($>100$ kHz) and high junction temperatures ($>200\text{C}$). Since the selection of the inverter topology is highly dependent on the power device characteristics, the emergence of power devices with new semiconductor properties demands a reevaluation of the system configuration. This paper investigates the combination of new WBG power devices and CSIs for use in integrated motor drive applications, identifying several promising features that are now undergoing further investigation.
On-Demand CMOS-Compatible Fabrication of Ultrathin Self-Aligned SiC Nanowire Arrays.

The field of semiconductor nanowires (NWs) has become one of the most active and mature research areas. However, progress in this field has been limited, due to the difficulty in controlling the density, orientation, and placement of the individual NWs, parameters important for mass producing nanodevices. The work presented herein describes a novel nanosynthesis strategy for ultrathin self-aligned silicon carbide (SiC) NW arrays (≤ 20 nm width, 130 nm height and 200–600 nm variable periodicity), with high quality (~2 A surface roughness, ~2.4 eV optical bandgap) and reproducibility at predetermined locations, using fabrication protocols compatible with silicon microelectronics. Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, ultraviolet-visible spectroscopic ellipsometry, atomic force microscopy, X-ray diffractometry, and transmission electron microscopy studies show nanosynthesis of high-quality polycrystalline cubic 3C-SiC materials (average 5 nm grain size) with tailored properties. An extension of the nanofabrication process is presented for integrating technologically important erbium ions as emission centers at telecom C-band wavelengths. This integration allows for deterministic positioning of the ions and engineering of the ions’ spontaneous emission properties through the resulting NW-based photonic structures, both of which are critical to practical device fabrication for quantum information applications. This holistic approach can enable the development of new scalable SiC nanostructured materials for use in a plethora of emerging applications, such as NW-based sensing, single-photon sources, quantum LEDs, and quantum photonics.
Win-Win Negotiation in a Global Economy

Negotiation is an essential skill for business leaders. However, the global, networked economy presents vexing challenges for negotiators who want to reach win-win outcomes. Negotiation involves a delicate balance of two motivations—cooperation that paves the way toward information sharing necessary to increase mutual gain, but also competition in that parties do not share similar incentive structures. We explore obstacles as well as solutions to negotiation on a global stage. Specifically, we examine how 6 factors, including: cultural differences, ethical concerns, political events, information technology, “big data,” and networks affect the process and outcome of effective negotiation.
NGOs and Global Leadership Development

Although numbering almost 20.7 million globally, nurses are difficult to identify within health focused nongovernmental organizations despite delivering the majority of health services in the sector (WHO, Global strategic directions for strengthening nursing and midwifery: 2016-2020, global-strategic-midwifery2016-2020.pdf, 2016). Partners In Health, a Boston-based NGO recognized as a leader in global health delivery, provides a retrospective case study documenting the organization’s roots and the evolution of nursing within its history. The case study highlights two Partners in Health country sites in Haiti and Liberia which showcase nursing leadership as a mechanism to improve patient care but also showcase the realities of developing and improving the nursing profession in challenging conditions. This chapter provides tangible steps and lessons learned that can benefit any health care provider interested in opportunities to work with NGOs.
Associations that produce significant publications for the health sciences: results from tracking a phantom literature.

Recensement d'associations en medecine et en sante qui publient des documents et ouvrages interessants pour les bibliotheques specialisees et pour les chercheurs
CAR-T Cell Therapy-Related Neurotoxicity in Pediatric Acute Lymphoblastic Leukemia: Spectrum of Imaging Findings

The emergence of CD19-targeted chimeric antigen receptor-T (CAR-T) cell therapy has created a new era in the management of pediatric patients with refractory B-cell malignancies such as B-cell acute lymphoblastic leukemia. Immune effector cell-associated neurotoxicity syndrome (ICANS) is frequently encountered in the postinfusion period of CD19-targeted chimeric antigen receptor-T cell therapy and in some cases may be fatal. Knowledge related to the spectrum of imaging findings of CD19-targeted CAR-T cell therapy-related ICANS is, however, still very much lacking, underscoring the need for continued research in this area. In this review, we hope to provide an overview of current knowledge and provide an in-depth literature review related to this topic. A brief discussion of possible imaging differential diagnoses, specifically in children with acute lymphoblastic leukemia, will also be included. Illustrative cases for each imaging phenotype will be provided to facilitate a better understanding. A greater level of insight of the spectrum of imaging findings related to ICANS will improve patients' management and enhance efforts to safely deliver CAR-T cell immunotherapy. It will also facilitate further studies to derive mechanistic insights of ICANS and potentially assist in the testing and monitoring of therapeutic interventions.
Conversion Experiences of Adults in El Salvador

This project aims to conduct a phenomenological study of religious conversion experiences of adults in El Salvador and utilizes Lewis Rambo’s systemic stage model to aid in the understanding of the said conversion experiences. In this article, Rambo’s systemic stage model is briefly delineated and Christianity in El Salvador is examined. Then, the survey of 20 adult Christians and their conversion experiences in El Salvador is analyzed. The analysis of the survey addresses the method, results, discussion of the results, and limitations of the study.
Multilingual Access and Services for Digital Collections: by Jiangping Chen, Santa Barbara, CA: Libraries Unlimited, 2016, $63.23, 236pp., ISBN 978-1440839542

Multilingual Access and Services for Digital Collections by Jianping Chen takes on the daunting task of describing complex topics, such as cross-language information retrieval and machine translati...
Social Risk Factors for Interpersonal Violence Victimization among College Students: Findings from a Mixed-Gender Sample

In this study, we explored social affiliations (participation in athletics, fraternities/sororities, student government, student unions, study abroad programs, faith groups, and other student organ...
Managing Polypharmacy in Older Adults with Cancer Across Different Healthcare Settings

The care of older patients with cancer is becoming increasingly complex. Common challenges for this population include management of comorbidities, safe transitions of care, and appropriate medication use. In particular, polypharmacy-generally defined as the regular use of five or more medications-and inappropriate medication use can lead to adverse effects and poor outcomes in older adults with cancer, including falls, hospital readmissions, cognitive impairment, poor adherence to essential medications, chemotherapy toxicity, and increased mortality. Managing polypharmacy across different cancer care settings is often challenging. Providers face barriers to safe and successful medication management that may include lack of time, absence of reimbursement, underappreciation of the scale of polypharmacy-related harm, lack of ownership of deprescribing efforts, and poor communication across care settings. Existing literature on managing inappropriate medication use and polypharmacy in older adults with cancer has often focused on ideal state settings in which resources are plentiful and time is purposefully allocated for medication interventions. This paper presents a narrative, rather than a systematic review, of studies published in the past decade that provided detailed information on medication management and polypharmacy across cancer care settings. This review aims to also summarize different healthcare provider roles in taking action against inappropriate medication use and polypharmacy in older adults with cancer.
Jeavons-Syndrom

Das Syndrom der Augenlidmyoklonien mit Absencen (Jeavons-Syndrom) ist durch augenschlussinduzierte Lidmyoklonien mit oder ohne Absencen, begleitende generalisierte EEG-Paroxysmen und Fotosensibilitat charakterisiert. Schwierigkeiten in der Diagnosefindung bereiten die Abgrenzung einfacher Lidmyoklonien als Anfallsform bei idiopathisch generalisierten Epilepsien und eine veranderte Fotosensitivitat unter antikonvulsiver Medikation. Es werden anhand zweier klinischer Beispiele die typischen Befunde des Jeavons-Syndroms dargestellt und differenzialdiagnostische Schwierigkeiten aufgezeigt.
Marble: collaborative scheduling of batteryless sensors with meta reinforcement learning

Batteryless energy-harvesting sensing systems are attractive for low maintenance but face challenges in real-world applications due to low quality of service from sporadic and unpredictable energy availability. To overcome this challenge, recent data-driven energy management techniques optimize energy usage to maximize application performance even in low harvested energy scenarios by learning energy availability patterns in the environment. These techniques require prior knowledge of the environment in which the sensor nodes are deployed to work correctly. In the absence of historical data, the application performance deteriorates. To overcome this challenge, we describe here the use of meta reinforcement learning to increase the application performance of newly deployed batteryless sensor nodes without historical data. Our system, called Marble, exploits information from other sensor node locations to expedite the learning of newly deployed sensor nodes, and improves application performance in the initial period of deployment. Our evaluation using real-world data traces shows that Marble detects up to 66% more events in low lighting conditions, and up to 25.6% more events on average on the first 3 days of deployment compared to the state-of-the-art.1