cssi/SciSciGPT-SciSciNet huggingface dataset:
MP3: ROLE OF HISTONE DEACTYLASE (HDAC) INHIBITORS IN ADULT T-CELL LYMPHOMA/LEUKEMIA (ATL)

Purpose of Study ATL is a peripheral T-cell neoplasm(PTCL) associated with human T-cell lymphotropic virus-1 (HTLV-1) infection. Currently there is no established therapy for relapsed/refractory disease. Initial in-vitro studies of HDAC inhibitors showed selective apoptosis of HTLV-1 infected T cell lines. In phase II trial for relapsed/refractory PTCL, 2 patients had EBV and 1 patient had HBV reactivation. It was unclear if this was from HDAC induced immunosuppression or direct promotion of viral replication or underlying disease process. All HDAC inhibitors trials in last 6 years excluded ATL patients although they are approved for this disease. We here describe our experience of 3 patients with relapsed/refractory ATL treated with HDAC inhibitor romidepsin. Methods Used Chart review of patients with relapsed/refractory ATL treated with romidepsin at King9s County Hospital. Summary of Results Case 1: 43 year old male with acute ATL who progressed on EPOCH after 4 cycles. Romidepsin was started at 14 mg/m2 IV Day 1, 8, 15 Q28 days. He tolerated cycle 1 well but continued to have progressive disease. Patient died 40 days after initiation of therapy from infection. Case 2: 37 year old male with acute ATL who had disease progression on EPOCH×2 cycles. He was started on romidepsin 10 mg/m 2 IV (dose reduced due to T. bili 3.5 gm/dl). After first dose, his platelets dropped to to 20 k/mm 3 necessitating treatment delay and dose reduction to 6 mg/m2. He had temporary response as evidenced by reduction in WBC count from 103 kmm 3 to 5 k/mm 3 and improvement in liver function. He only received 1 cycle and died on Day 50 from disease progression. Case 3: 47 year old male with ATL lymphoma intially treated with CHOP×6 cycles and relapsed after 1 year with peripheral lymphocytosis to 57 k/mm 3 and diffuse lymphadenopathy. He received ICE×2 cycles with progressive disease. He was started on romidepsin 14 mg/m 2 . He received 1 dose and had Grade IV anemia/thrombocytopenia. He developed urosepsis and expired on Day 20. Conclusions In our small experience of romidepsin in relapsed/refractory ATL, patients appear to have modest response rates and higher rate of cytopenias when compared to other PTCL subtypes in clinical trials. Given the concerns for viral reactivation and lack of data for use of romidepsin in ATL, it should be used cautiously.
A comparison of parallel versus perpendicular placement of retention sutures in abdominal wound closure.

Abstract A new technique for placement of retention sutures is described. Twenty-five rats underwent midline laparotomy incision. The control group was closed with traditional placement of through-and-through retention sutures placed in a perpendicular direction to the wound. The experimental group was closed with retention sutures placed in a parallel direction to the wound as described below. Wound bursting strength was significantly (P less than 0.001) greater at one to five days in the experimental group compared with the control animals. In addition, inflammatory reaction and pressure necrosis were greater in the control group. It appears that parallel placement of sutures has less of a tendency to cut through tissue when subjected to the distracting forces on a midline wound.
Policy interventions on children and physical activity: Lazio and Tuscany in Italy

Intervention aim The stewardship interventions in Italy were devoted to two local policies. In Lazio Region, Municipaliadi, the intervention was as sports competition for school children, promoted by the Municipality of Rome integrating education and physical activity. A Delphi-like working group on knowledge and research translation into policy making was used by …
A new application for the removal of caliceal renal stones with the rigid ureteropyeloscope.

AbstractStone migration into the kidney can result in failure to remove a ureteral stone with a ureteroscope. A new application with the rigid ureteropyeloscope was used to remove a ureteral stone that had migrated into a lower renal calix. Under fluoroscopic control a 9F catheter was advanced next to the stone through the emptied sheath of the ureteropyeloscope whose tip was in the upper ureter. Then a basket was placed through the catheter and was used to trap and remove the stone.
Stabilizing a high-temperature electrochemical silver-carbonate CO2 capture membrane by atomic layer deposition of a ZrO2 overcoat

A high-selectivity and high-flux electrochemical silver-carbonate dual-phase membrane was coated with a nanoscaled ZrO2 layer by atomic layer deposition (ALD) for stable CO2 capture at high-temperature (≥800 °C); the latter has an important implication for direct dry methane reforming with the captured CO2 and O2 for syngas production.
The interaction between Pagurus bernhardus (L.) and Hydractinia echinata (Fleming)

Abstract Experiments showed that Pagurus bernhardus reacts positively to the presence of Hydractinia echinata and that the sensation is of a chemical nature.
The ability to infect others with emotion

Introduction If we pursue the analogy, thinking of the transmission of moods as akin to the transmission of social viruses, it seems reasonable to suppose that some people (the Typhoid Marys of this world) may well possess a natural ability to infect others with the “virus” while others (the Marcel Prousts) stand especially vulnerable to contagion. Norman Mailer (1979), in The Executioner's Song , interviewed Nicole Baker, the girlfriend of condemned killer Gary Gilmore. While Gilmore was on death row, Nicole had a brief affair with two men. Nicole loved Tom because he was able to infect her with his cheerful emotions. She loved Cliff Bonnors because he was in tune with her deepest feelings: Cliff Bonnors was great because he always brought his mood around to meet hers. They could travel through the same sad thoughts never saying a word. Tom, she liked, for opposite reasons. Tom was always happy or full of sorrow, and his feelings were so strong he would take her out of her own mood. He wasn't dynamite but a bear full of grease. Always smelled full of hamburgers and french fries. He and Cliff were beautiful. She could like them and never have to worry about loving them one bit. In fact, she enjoyed it like a chocolate bar. Never thought of Gary when making love to them, almost never, (p. 329) In this chapter, we consider the kinds of individual differences that affect men's and women's ability to shape an emotional climate.
Vitamin D: Biology, Actions, and Clinical Implications

Abstract Vitamin D is the major regulator of calcium homeostasis in the body and is critically important for normal mineralization of bone to prevent rickets in children and osteomalacia in adults. The active hormone, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3, also called calcitriol), is produced by sequential hydroxylations of vitamin D in the liver (25-hydroxylation) and the kidney (1α-hydroxylation). 1,25(OH)2D3 acting via the vitamin D receptor (VDR), functions by a genomic mechanism similar to the classical steroid hormones to regulate target gene transcription. The traditional actions of 1,25(OH)2D3 are to enhance calcium and phosphate absorption from the intestine in order to maintain normal mineral concentrations in the circulation and to provide adequate amounts of these minerals to the bone-forming sites to allow mineralization of bone to proceed normally. However, since the early 1990s, it has become increasing clear that vitamin D has many additional extraskeletal functions that implicate the hormone in a wide array of actions unrelated to bone or mineral metabolism. It is now known that 1,25(OH)2D3 modulates the activity of hundreds, if not thousands, of genes in essentially every tissue in the body making it a potent regulator of many critical processes. Some of these actions can be categorized as antiproliferative, prodifferentiating, immunosuppressive, and anti-inflammatory. In this chapter, we will describe the basic biology of vitamin D including its metabolism, physiology, mechanism of action, and its diverse functions in the body including those actions that relate to mineral metabolism as well as the newer extraskeletal actions. Several reviews of vitamin D mechanism of action and function have been published as well as a new edition of a comprehensive book addressing all areas of vitamin D biology. Specific issues relating to vitamin D and osteoporosis are discussed in Chapter 73.
The Role of Nitrogen Fixation in Seed Development of Soybean

Seasonal nitrogen fixation profiles of soybean (Glycine max L. Merr) were published by Harper (1974), Thibodeau and Jaworski (1975) and others using acetylene reduction (AR) with washed, detached roots. They observed a decline a AR activity coincidential with increasing seed size. In a heavily cited article, Thibodeau and Jaworski hypothesized that the proximity of the pods to the leaves deprived the roots of carbohydrate and caused the decline in AR activity. Coupled with the observation that nitrate reductase activity ceases after flowering (Harper 1974), Thibodeau and Jaworski proposed a utilization model which concluded that nitrogen redistribution, rather than assimilation, satisfied the nitrogen requirement late in the season.
Pressure-dependent resonance frequency for lipid-coated microbubbles at low acoustic pressures

In this study, a flow-focusing microfluidic device was used to prepare lipid-coated microbubbles with a narrow size distribution. Size-controlled monodisperse microbubbles have been successfully produced with mean diameters ranging from 3.4–12.5 μm. These bubble populations were suspended in an exposure chamber and attenuation coefficients were measured by insonifing with 30-cycle narrow-band acoustic pulses at frequencies ranging from 0.5 to 4.5 MHz, and at four acoustic pressure amplitudes: 10 kPa, 20 kPa, 40 kPa, and 60 kPa. The resonance frequency was defined as the frequency where the peak attenuation coefficient was measured. It was shown that the resonance frequency decreased as the acoustic pressure increased, which was mainly due to the nonlinear behavior of the microbubbles. Compared with linear resonance frequency calculated for lipid-shelled microbubbles, the average changes of the resonance frequency at 10 kPa, 20 kPa, 40 kPa, and 60 kPa were 3.0%, −7.9%, −20.5%, and −27.6%, respectively.
A Trauma-Informed Approach to Affirming the Humanity of African American Boys and Supporting Healthy Transitions to Manhood

The dehumanization of boys and men in African American families is a historic and contemporary racial trauma that black males and their support systems must negotiate. While racial socialization and racial literacy strategies provide black males and their families with protective resources in response to racism, Stevenson (chapter “Dueling Narratives: Racial Socialization and Literacy as Triggers for Re-Humanizing African American Boys, Young Men, and Their Families”) notes that these interventions are not equipped to address the trauma resulting from black males’ racialized encounters. In this chapter, I apply a trauma-informed approach to affirm the humanity of boys and men in African American families and suggest the integration of a trauma-informed perspective with a racial literacy lens to support healthy transitions to manhood for this group.
ACT for Life: Using Acceptance and Commitment Therapy to Understand and Prevent Suicide

Human beings are the only living organisms that consciously and deliberately kill themselves. Moreover, suicide is present in all societies, and internationally nearly one in ten humans will consider suicide at some point during their lives. This has left many of us asking, “What is it about being human that causes so many people to consider killing themselves?” On the surface, the answer is not a simple one. There is not one clear pathway that leads to suicide. Suicide is associated with a broad array of stressors, mental illnesses, and demographic characteristics. Acceptance and Commitment Therapy (ACT) is a transdiagnostic psychosocial treatment approach grounded in a model of psychological (in)flexibility. ACT offers a compelling explanation for why suicide is uniquely human and heterogeneous in etiology, but has been understudied in regard to its applicability to suicide prevention. In the proposed chapter, we delineate the etiology of suicidal thoughts and behaviours according to the ACT model of psychological (in)flexibility. Further, we review and synthesize the extant literature relevant to this etiological model. Topics of focus include inflexible attention, experiential avoidance, cognitive fusion, attachment to a conceptualized self, and disruption of valued living. We discuss implications for suicide risk assessment and key considerations for using ACT to manage suicide risk (e.g. how to promote the acceptance of suicidal ideation, without encouraging suicidal behaviour and ways to identify new valued directions for taking action that strengthen protective factors). Case material is presented to illustrate how ACT can be used with suicidal individuals to help them build a life they deem worth living.
Caregiver Reactions to Aggressive Behaviors in Persons With Dementia in a Diverse, Community-Dwelling Sample.

Purpose: To describe caregiver challenges with and confidence managing three aggressive behavior types in persons with dementia: verbal aggression, destroying property, and threatening to hurt othe...
Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in intestinal neuroendocrine tumors: An analysis of the U.S. Neuroendocrine Tumor Study Group.

694Background: Intestinal neuroendocrine tumors (NETs) can often be indolent, with survival commonly exceeding 10 years. However, a subset can be more aggressive. The search for a prognostic test b...
Calculation of Model Tables

The model tables presented here are based on a tendency that we noted for the life tables based on accurate data to cluster around four different lines, representing distinct age patterns of mortality in certain geographical regions.
Missed opportunities in monitoring socioeconomic status.

Socioeconomic status (SES) is one of the strongest known predictors of variations in health status in both industrialized and less industrialized countries. Despite advancements in the quality and availability of medical care, the advent of universal education, increased economic development, and marked improvements in the standard of living during this century, the strong inverse association between SES and morbidity and mortality that was evident in our earliest health data has diminished little, if any, over time in the United States. This pattern exists for infant and adult mortality, chronic and infectious disease morbidity, and psychiatric morbidity. One recent study found, for example, that poverty makes a contribution to the national death rate in the United States that is comparable to that of cigarette smoking.[1]
Group Decision Making, Cognitive Psychology of

A group can be defined as a set of persons who interact in pursuit of a common goal. Decision making is prevalent in groups, both because many groups have the objective of choosing a course of action, and because decisions are necessary as members of any group attempt to coordinate their actions in pursuit of other objectives. Modern approaches to understanding the process of group decision making tend to view groups as information processors. Thus, theory and research on group decision making emphasizes the means by which information is acquired, distributed, evaluated, and combined by members. A serious challenge to groups is dealing effectively with cognitive conflict, heterogeneity among members in terms of their information, beliefs, and preferences. To make good decisions, groups must utilize the unique information of their individual members, and integrate their conflicting beliefs into a single group decision. Major differences among members in their roles for processing information can be understood by conceptualizing groups as Judge Advisor Systems, in which a Judge is responsible for deciding after input from one or more Advisors.
ENERGY METABOLISM IN THE LENS DURING AGING.

From a survey of studies pertaining to the effect of age on energy metabolism in the lens, it appears that during aging there is a decrease in the metabolic activity of the lens cytoplasm probably accompanied by an increase in the degree of utilization of aerobic reactions. Evaluation of metabolic activity from measurements of aerobic glycolysis and respiration requires defining a suitable basis of reference for which the water content of the lens seems appropriate. The reduction with age in activity defined on this basis may be controlled in part by the decrease in the surface/volume ratio during groioth of the lens. No correlation of over-all energy production and growth rate was found, but there is a suggestion that respiratory activity specifically might be coupled with growth. Indirect evidence of a decrease in glycolytic activity with age is provided by observed decreases in lactic acid concentration, turnover of phosphate in glycolytic intermediates, and possibly cation transport. Any change in ATP conitent is not conclusive evidence of a change in metabolic activity; the constancy of ATP turnover with age, however, suggests unchanging metabolic activity in at least the outer layers of the lens. The total picture of phosphate turnover in the lens at different ages points to relative changes in the types of reactions utilized for energy production. Evidence of an increase in the use of aerobic pathways relative to anaerobic in older bovine lenses is provided both by direct studies with 1J >C-glucose and indirectly by the increase in the ratio of pyruvate to lactate. The situation in the rat lens is not clear, but in general a decrease in aerobic metabolism appears to be indicated. T, he changes which occur with age in the metabolism of the lens are of considerable interest in view of the high degree of susceptibility of young lenses to certain cataractogenic agents. Development of senile cataracts also may be related to metabolic changes in the lens during aging.
Parametric Cluster Analysis and Mixture Regression

This chapter is about advanced parametric clustering techniques based on the concept of mixture distributions. The first section introduces mixture distributions from a general perspective, followed by two popular applications in clustering: normal mixture models (latent profile analysis) for metric input variables and multinomial mixture models (latent class analysis) for categorical variables. Subsequently, these ideas are extended to mixed input scale levels. In the following section, the mixture distribution concept is embedded into a regression framework. In mixture regression models, clustering and estimation of regression parameters are performed simultaneously. By means of Dirichlet process regression, we add another complexity layer to the modeling framework by letting an algorithm determine the optimal number of clusters. Finally, the focus is on latent Dirichlet allocations: topic models for clustering text data.
Privilege, White Identity, and Motivation: A Call to Action in Social Work

Understanding how privilege is constructed and reconstructed over time is imperative to move toward a more just society. White fragility and tactics used to avoid race-based stress sustains privile...
Doctor or firefighter

Role-play on the themes of health, wellbeing and emergency services can familiarise children with these services and help them overcome anxiety which might arise when visiting health professionals.
Timelessness and Precarity in Orientalist Temporality: Mehdi-Georges Lahlou’s Aesthetics of Disorientation

The Hourglasses (2015), by French-Moroccan artist Mehdi-Georges Lahlou, features five large hourglasses displayed artifact-like upon a table. As one would expect of an hourglass, these glass sculptures can be inverted to measure out time. This, though, is where convention ends, as these are filled with couscous, not sand. Unlike sand, couscous cannot measure time consistently and the inversion of any one of these five hourglasses results in a different measurement of time. In effect, they disorient any linear notion of temporality, raising the specter of Orientalism and its fantasy of a timeless East. Mehdi-Georges works in a diverse range of media including performance, sculpture, installation, and self-portraiture. Dealing with race, gender, sexuality, colonialism, identity, and representations of Islam and Catholicism, his work performs the instability in all these categories by critically complicating fantasies of “East” and “West” without relying on a mere binary reversal of meaning. Contextualizing his work within a larger history of Orientalism, my argument begins first with Percy Bysshe Shelley’s poem “Ozymandias,” composed in 1817, followed by an analysis of nineteenth- and twentieth-century Orientalist paintings before leading to a concise discussion of contemporary Orientalism in art and art discourse. My analysis then circles back to the artist’s work to insist that Orientalism’s fantastical invocation of the East remains a disabling presence in the contemporary imaginary. Orientalism’s temporality, as glimpsed obliquely from Mehdi-Georges Lahlou’s hyphenated identity, is likewise rendered unstable in his work. As seen in The Hourglasses, his work produces what I call “an aesthetic of disorientation,” predicated on the artist’s embodied cultural hyphenation, which renders the Orientalist fantasy of the East absurd through its own tropes of representation. By bringing queer theory and disability studies to bear on his work, I show how his practice engages with Orientalism’s temporality to open up new possibilities of perceiving the world.
Swift machine learning model serving scheduling: a region based reinforcement learning approach

The success of machine learning has prospered Machine-Learning-as-a-Service (MLaaS) - deploying trained machine learning (ML) models in cloud to provide low latency inference services at scale. To meet latency Service-Level-Objective (SLO), judicious parallelization at both request and operation levels is utterly important. However, existing ML systems (e.g., Tensorflow) and cloud ML serving platforms (e.g., SageMaker) are SLO-agnostic and rely on users to manually configure the parallelism. To provide low latency ML serving, this paper proposes a swift machine learning serving scheduling framework with a novel Region-based Reinforcement Learning (RRL) approach. RRL can efficiently identify the optimal parallelism configuration under different workloads by estimating performance of similar configurations with that of the known ones. We both theoretically and experimentally show that the RRL approach can outperform state-of-the-art approaches by finding near optimal solutions over 8 times faster while reducing inference latency up to 79.0% and reducing SLO violation up to 49.9%.
Collective Property Rights and Social Citizenship: Recent Trends in Urban Latin America

This article argues that efforts to implement collective property ownership via community land trusts (CLTs) in Latin America can be seen as a viable means for reducing socio-spatial inequalities, strengthening the urban poor’s ‘right to the city,’ and enabling more substantive social citizenship. It begins by arguing that, in Latin America, market models intended to strengthen individual property rights can increase urban inequality and spatial exclusion. It then examines recent measures undertaken to reverse the negative impacts of these patterns, focusing explicitly on the adoption of CLTs and how they serve as a means for strengthening urban citizenship. After highlighting the fact that CLTs have proliferated in the US and Europe but not Latin America, we explain how and why a few Latin American countries have nonetheless embraced CLTs. Building on deeper analysis of two cases in the region, Puerto Rico and Brazil, we show that despite the legal and governance constraints of Latin American cities, CLTs can materialise when local authorities join with citizens to embrace these models.
Quantitative Approaches to Community College Student Health: A Systematic Review of the Literature

ABSTRACTObjective: Health is an important factor in college student success yet is not as well understood in two-year colleges as it is in traditional, four-year institutions. This systematic liter...
An evaluation of buparlisib for the treatment of head and neck squamous cell carcinoma.

Five-year overall survival for head and neck squamous cell carcinoma (HNSCC) is relatively poor at around 50–66%, and there has been little improvement over the past several decades. PIK3CA alterat...
Surrogacy and the Politics of Pregnancy

This Essay examines the regulation of pregnancy through a less commonly explored lens — surrogacy legislation. Initially, the dominant position of feminist advocates was to understand the practice of surrogacy as antithetical to women’s equality and reproductive autonomy. Due in part to their active and persuasive involvement, the early legislative trends tracked this position; most of the legislation enacted in the 1980s and early 1990s banned surrogacy. By the mid-1990s, however, the legislative tide turned. All of the comprehensive surrogacy statutes enacted since that time permit and regulate surrogacy. This shift was due in part to a growing sense among some feminists and others that permitting surrogacy can promote the goals of liberty and equality. At times, however, too little attention was paid to the details of these permissive surrogacy schemes. As a result, permissive surrogacy statutes in some states may undermine these aims. This Essay focuses on one such type of statute: surrogacy provisions that authorize potentially sweeping control over the lives, bodily integrity, and decision making of people acting as surrogates. For example, a number of permissive surrogacy schemes expressly authorize contract clauses that require people acting as surrogates to undergo risky and invasive medical procedures over their clearly stated, contemporaneous objection. But such schemes are not inevitable. This Essay concludes by highlighting recent examples that illustrate how permissive surrogacy legislation can foster, rather than impede, the ability of people to control decisions about their own bodies.
Are Gifted Students Adapting Their Self-Regulated Learning Processes When Experiencing Challenging Tasks?:

Self-regulated learning (SRL) promotes both current and future academic achievement and must be adapted based on task demands. To develop SRL, gifted students must have opportunities to experience ...
Harnessing the power of chemically active sheets in solution

In living organisms, diffusing chemicals react with soft tissue to actuate a range of mechanical actions, such as periodic pulsations or net motion. Inspired by this biological behaviour, researchers have created chemically active ‘microswimmers’ that translate chemical input into mechanical work. Because typical microswimmers are hard spheres (that is, zero-dimensional objects) and rigid or flexible rods (1D objects), their movements are constrained relative to higher dimensional, soft matter. In recent years, these limitations have motivated research on 2D active sheets that undergo shape changes or directed motion in response to chemical cues in solution; the combination of dimensionality, chemical activity and structural flexibility leads to new, rich dynamic behaviour. In one class of materials, chemical reactions generate internal stresses in the 2D sheets that trigger the shape transformations; in the second class, the release of energy from chemical reactions drives a fluid flow, which not only transports but also morphs the shape of the sheet. Consequently, these reconfigurable, self-propelled sheets can perform self-sustained operations that were unattainable with previously studied active particles, including self-morphing and self-oscillating behaviour. The latter functionalities can lead to the creation of portable, chemical machines and the discovery of new modes of dynamic self-assembly. Chemically active, flexible sheets convert chemical energy into the flow of the surrounding fluid, which, in turn, transforms the sheet’s shape. This Perspective describes how this feedback produces shape-changing 3D objects, coupled oscillators exhibiting spatiotemporal coordination and the rotation of chemically driven gears.
A neural probabilistic model for context based citation recommendation

Automatic citation recommendation can be very useful for authoring a paper and is an AI-complete problem due to the challenge of bridging the semantic gap between citation context and the cited paper. It is not always easy for knowledgeable researchers to give an accurate citation context for a cited paper or to find the right paper to cite given context. To help with this problem, we propose a novel neural probabilistic model that jointly learns the semantic representations of citation contexts and cited papers. The probability of citing a paper given a citation context is estimated by training a multi-layer neural network. We implement and evaluate our model on the entire CiteSeer dataset, which at the time of this work consists of 10,760,318 citation contexts from 1,017,457 papers. We show that the proposed model significantly outperforms other state-of-the-art models in recall, MAP, MRR, and nDCG.
Assessment and interpretation of comorbidity burden in older adults with cancer.

OBJECTIVES: To evaluate the associations between comorbidities, functional limitations, geriatric syndromes, treatment patterns, and outcomes in a population-based cohort of older patients diagnosed with colorectal cancer and receiving home health care. DESIGN: Retrospective study. SETTING: Data from the Ohio Cancer Incidence Surveillance System, Medicare claims and enrollment files, and the home health care Outcome and Assessment Information Set. PARTICIPANTS: Ohio residents diagnosed with incident colorectal cancer in 1999 to 2001 and receiving home health care in the 30 days before or after cancer diagnosis (N = 957). MEASUREMENTS: Outcome measures included receipt of cancer treatment and survival through 2005. RESULTS: Not having surgery was associated negatively with comorbidities but positively with functional limitations and geriatric syndromes. Receipt of chemotherapy was negatively associated with comorbidities and functional limitations. The presence of two or more geriatric syndromes was significantly associated with unfavorable survival outcomes when analyzing overall survival and disease-specific survival (DSS). Having limitations in two or more activities of daily living was associated with unfavorable overall survival but not with DSS. Comorbity was associated with favorable DSS at borderline level of statistical significance but not with overall survival. CONCLUSION: The findings highlight the importance of incorporating functional limitations and geriatric syndrome data in geriatric oncology outcomes studies.
Spectral Tangential Interpolation and Gain Margin Problems

In this note we will discuss a new kind of interpolation theory in which one bounds the spectral radius of the matrix-valued interpolating functions instead of the norm as is the case with ordinary Nevanlinna-Pick interpolation. We relate this to the multivariable gain margin problem.
Fertility treatment in the forty and older woman.

Purpose: To determine the outcomes and logical progression of fertility treatment in women forty years and older using their own oocytes.
The ToxT‐dependent methyl‐accepting chemoreceptors AcfB and TcpI contribute to Vibrio cholerae intestinal colonization

Vibrio cholerae colonizes the human intestine and causes the acute diarrheal disease cholera. Flagellar-mediated chemotaxis contributes to intestinal colonization as well as infectivity. The virulence-regulatory protein ToxT activates transcription of the genes encoding the major virulence factors cholera toxin and toxin coregulated pilus. ToxT additionally activates transcription of two genes, tcpI and acfB, located within the Vibrio Pathogenicity Island predicted to encode methyl-accepting chemoreceptors. We show that disruption of either tcpI or acfB individually does not noticeably affect V. cholerae intestinal colonization within the infant mouse, but disruption of both tcpI and acfB leads to a decrease in intestinal colonization. These results suggest that TcpI and AcfB may have overlapping or redundant chemotactic functions that contribute to V. cholerae intestinal colonization.
Evaluation of tibial interlocking intramedullary nails

Interlocking intramedullary nailing is currently the leading method of treating a wide assortment of tibial fractures. Satisfactory clinical performance of such a nail is interwoven with the mechanical characteristics (chiefly, static strength, fatigue strength, fatigue life and stiffness) of the nail-contiguous fractured bone construct. The present work reviews the open literature on these nails and the mechanical performance of the constructs. Based on the observations made in the review, areas for future work are identified and expounded upon.
The Local Frobenius Theorem

Let M be an n-dimensional smooth manifold. The tangent bundle TM of M is the disjoint union of all tangent spaces of points of M. It can be given the structure of a manifold of dimension \(2\dim (M)\) as follows. If U is a coordinate neighborhood and x 1, …, x n are local coordinates on U, then \(T(U) =\{ T_{x}M\,\vert \,x \in U\}\) can be taken to be a coordinate neighborhood of TM.
Current-mode biquadratic filter sections using a single current conveyor

The first generation current conveyor, CCI, permits the implementation of feedback of the response in current-mode circuits without sacrificing the high output impedance of the output port. This feature of CCI circuits, which is not inherently available in circuits containing a single second generation current conveyor, is exploited to realize new second-order, complex-pole current-mode low-pass, band-pass, and high-pass networks. These new circuits' passive sensitivities and frequency limitations are described and laboratory results are presented. >
Noncoherent demodulation techniques for trellis coded M-DPSK signals

Considers noncoherent decoding of trellis coded M-DPSK transmission, and attempts to unify and contrast the approaches to this problem which have been previously reported. In the second part of the paper, the maximum likelihood block decoders for the AWGN channel are outlined, first assuming that the decoder has no knowledge of the state of the encoder at the beginning of the block, and then assuming that it knows the state. Because these exhaustive decoders suffer from an exponential growth in complexity with block length, two simplified decoders are proposed that approach the performance of the exhaustive decoders with a much more manageable complexity. Through a union bound analysis and computer simulations, it is shown that it is possible to achieve large gains over uncoded systems with a very reasonable decoder complexity. >
New series representations for generalized Nuttall Q-function with applications

In this article, we derive six distinct series representations of the generalized Nuttall Q-function. Interestingly, some of these expressions generalise some of the recent results on series representation of the Marcum Q-function since the Marcum Q-function is a special case of the Nuttall Q-function. To the best of our knowledge, five of these representations are novel and the other one is included for the completeness of the article. The performances of these representations are compared using the magnitude of the truncation error which gives a measure of the accuracy and rate of convergence and allow us to show the strength of each representation. We then discussed the area of applications of our result. We showed that our Nuttall Q-function representations and their corresponding special case (Marcum Q-function) (though not limited to only these), can be used in (i) the computation of outage probability of wireless communication system with co-channel interferers, (ii) the evaluation of detection probability of energy detector over generalized fading channels in cognitive radio system, and (iii) the computation of cumulative distribution of selection diversity combining in correlated Nakagami-m fading channel. In all these areas of application, our solution has no restriction on any parameter of interest.
The program for academic survival skills (pass): Effects on student behavior and achievement☆

Abstract The effects of the Program for Academic Survival Skills (PASS), a group behavior management program, on behavioral observation data and standardized achievement test measures were investigated. Fifty-four of the 96 selected low-achieving, low-survival-skill students of normal IQ were assigned to an experimental condition in which their teachers used PASS. The remaining 42 were assigned to a control condition. Results indicated PASS produced significant gains in survival skills during its operation and one week following program termination in both reading and mathematics periods across grades 1–3. Findings for achievement indicated a significant gain for first-grade experimentals only in reading, with a similar but nonsignificant gain for first-grade mathematics.
Tricuspid valve prolapse associated with myxomatous degeneration

Two surgical patients are presented with tricuspid valve prolapse. One had severe isolated prolapse of the posterior leaflet at its junction with the anterior leaflet accompanied by chordal elongation that was successfully repaired; the other had mild prolapse of all three leaflets with chordal elongation. Myxomatous degeneration of the tricuspid valve was the suspected underlying pathologic disorder in both patients and was histologically proven in the resected leaflet tissue of patient 1.
Kinetics of protein-mediated transfer of rat pancreatic microsomal phosphatidylinositol to liposomes

Pancreatic microsomes were isolated from fasted and pilocarpine-injected rats and the microsomal phosphatidylinositol radiolabelled with myo-[2-3H]inositol by isotopic exchange. A standard reaction mixture was established in which partially purified rat liver phosphatidylinositol exchange proteins sustain a maximal rate of phosphatidylinositol transfer from rat pancreatic microsomes to liposomes. Determination of the transfer kinetics shows (1) that pancreatic microsomal phosphatidylinositol is partitioned approximately equally between a non-exchangeable and a single exchangeable pool and (2) that cholinergic stimulation does not significantly change the relative sizes of the two pools nor the exchange half-life of the latter pool.
PPARγ in endothelial cells influences high fat diet-induced hypertension

Background Peroxisome proliferator-activated receptor γ (PPARγ) ligands improve human hypertension. However, the mechanism and site of this effect remains unknown, confounded by PPARγ expression in many cell types, including endothelial cells (ECs). Methods To evaluate the vascular role of PPARγ we used a conditional null mouse model. Specific disruption of PPARγ in ECs was created by crossing Tie2-Cre+ transgenic (T2T+) and PPARγ-floxed (fl/fl) mice to generate PPARγ (fl/fl)T2T+ (PPARγ E-null) mice. Conscious 8- to 12-week-old congenic PPARγ (fl/fl)Cre− (wild type) and PPARγ E-null mice were examined for changes in systolic blood pressure (BP) and heart rate (HR), untreated, after 2 months of salt-loading (drinking water), and after treatment for 3 months with high fat (HF) diet alone or supplemented during the last 2 weeks with rosiglitazone (3 mg/kg/d). Results Untreated PPARγ E-nulls were phenotypically indistinguishable from wild-type littermates. However, compared to similarly treated wild types, HF-treated PPARγ Ẽ-nulls had significantly elevated systolic BP not seen after normal diet or salt-loading. Despite sex-dependent baseline differences, salt-loaded and HF-treated PPARγ Ẽ-nulls of either sex had significantly elevated HR versus wild types. Interestingly, rosiglitazone improved serum insulin levels, but not HF diet-induced hypertension, in PPARγ Ẽ-null mice. Conclusions These results suggest that PPARγ in ECs not only is an important regulator of hypertension and HR under stressed conditions mimicking those arising in type 2 diabetics, but also mediates the antihypertensive effects of rosiglitazone. These data add evidence supporting a beneficial role for PPARγ-specific ligands in the treatment of hypertension, and suggest therapeutic strategies targeting ECs may prove useful.
Misuse of Forensic Hypnosis: A Hypnotically Elicited False Confession with the Apparent Creation of A Multiple Personality

Abstract A case is presented in which there was flagrant misuse of forensic hypnosis. The patient, a woman in her early 30s, was accused of shooting her 2 children. During a hypnotic interview, the police hypnotist used an extremely suggestive interrogative technique, and the suspect produced an apparent secondary personality who confessed to the shootings. Subsequently the prosecutor tried to enter the “hypnotic confession” as evidence against the defendant. The evidence was disallowed because of the manner in which it was obtained and because of the lack of verification from other sources. The literature regarding the use of forensic hypnosis is reviewed as is the literature regarding multiple personality and the experimental production of multiple personality-like phenomena.
Perceptions of a Quality Program and Relationships with Work Perceptions and Job Attitudes

Numerous organizations have incorporated quality-oriented interventions to improve effectiveness; however, little systematic research has concerned how employees' perceptions about such interventio...
Promoter and piggyBac activities within embryos of the potato tuber moth, Phthorimaea operculella, Zeller (Lepidoptera: Gelechiidae)

Potato production in tropical and subtropical countries suffers from damage caused by the potato tuber moth (PTM), Phthorimaea operculella. The aim of this research was the development of the components required for a germline transformation system for the PTM. We tested three components that are critical to genetic transformation systems for insects: promoter activity, marker gene expression, and transposable element function. We compared the transcriptional activities of five different promoters, hsp70, hsp82, actin5C, polyubiquitin and immediate early 1 gene (ie1), within PTM embryos. The ie1 promoter, flanked by the hr5 enhancer element, showed a very high level of transcriptional activity compared to the other promoters. The fluorescence activity of EGFP was also determined and transient expression of EGFP was detected in 57% of injected embryos. The transpositional activity of the piggyBac transposable element was tested in an interplasmid transposition assay. The piggyBac element was shown to be mobile within the embryonic soma of the PTM with a transposition frequency of 4.2 x 10(-5) transpositions/donor plasmid. Incorporating a transactivator plasmid expressing the immediate early protein (IE1) from the Bombyx mori nuclear polyhedrosis virus enhanced the efficiency of piggyBac mobility.
Predicting diagnostic error in radiology via eye-tracking and image analytics: preliminary investigation in mammography.

Purpose: The primary aim of the present study was to test the feasibility of predicting diagnostic errors in mammography by merging radiologists’ gaze behavior and image characteristics. A secondary aim was to investigate group-based and personalized predictive models for radiologists of variable experience levels. Methods: The study was performed for the clinical task of assessing the likelihood of malignancy of mammographic masses. Eye-tracking data and diagnostic decisions for 40 cases were acquired from four Radiology residents and two breast imaging experts as part of an IRB-approved pilot study. Gaze behavior features were extracted from the eye-tracking data. Computer-generated and BIRADS images features were extracted from the images. Finally, machine learning algorithms were used to merge gaze and image features for predicting human error. Feature selection was thoroughly explored to determine the relative contribution of the various features. Group-based and personalized user modeling was also investigated. Results: Machine learning can be used to predict diagnostic error by merging gaze behavior characteristics from the radiologist and textural characteristics from the image under review. Leveraging data collected from multiple readers produced a reasonable group model [area under the ROC curve (AUC) = 0.792 ± 0.030]. Personalized user modeling was far more accurate for the more experienced readers (AUC = 0.837 ± 0.029) than for the less experienced ones (AUC = 0.667 ± 0.099). The best performing group-based and personalized predictive models involved combinations of both gaze and image features. Conclusions: Diagnostic errors in mammography can be predicted to a good extent by leveraging the radiologists’ gaze behavior and image content. © 2013 American Association of Physicists in Medicine .[ http://dx.doi.org/10.1118/1.4820536]
On Learned Ignorance

Face au faillibilisme cognitif et a l'estimation de la verite qui nous imposent de faire de notre mieux dans la recherche de la connaissance, l'A. montre que l'incapacite de repondre a toutes les questions nous confronte a l'inevitabilite de l'ignorance. Sans tomber dans un negationnisme cognitif, l'A. reste optimiste en ce qui concerne la possibilite d'une informaton fiable et l'orientation de l'action dans un monde favorable. Soulignant le caractere vague de la pensee, l'A. etudie la strategie qui consiste a differencier la verite de l'erreur, d'une part, et a mesurer la surete de la connaissance en fonction du calcul du risque cognitif, d'autre part
A Tale of Two Jets

One of the most astounding astrophysical phenomena is the existence of highly collimated jets of highly energetic particles found emanating from localized regions in the sky. These jets are ubiquitous, having been observed in the radio and x-ray spectrum at the center of galaxies, gamma-ray bursts, and quasars. Although their precise generation mechanism remains unknown, these jets are believed to be powered by black holes. Black holes do not shine in isolation, because their gravitational field is so strong that not even light can escape their pull. However, they are usually accompanied by rotating disks of gas and dust matter (called accretion disks) and can form strongly collimated emissions through a variety of mechanisms. On page 927 of this issue, Palenzuela et al. ( 1 ) numerically model the merger of two black holes surrounded by an accretion disk that orbits around both of them (forming a circumbinary) and anchors a magnetic field perpendicular to the orbital plane. Each black hole generates a jet, produced by the twisting of the magnetic field lines as they lose energy and spiral toward each other (inspiral), even though the black holes are not spinning. Their simulations show the formation of two jets and their transition to a single jet as the black holes merge.