cssi/SciSciGPT-SciSciNet huggingface dataset:
Finding knowledge paths among scientific disciplines

This paper uncovers patterns of knowledge dissemination among scientific disciplines. Although the transfer of knowledge is largely unobservable, citations from one discipline to another have been proven to be an effective proxy to study disciplinary knowledge flow. This study constructs a knowledge-flow network in which a node represents a Journal Citation Reports subject category and a link denotes the citations from one subject category to another. Using the concept of shortest path, several quantitative measurements are proposed and applied to a knowledge-flow network. Based on an examination of subject categories in Journal Citation Reports, this study indicates that social science domains tend to be more self-contained, so it is more difficult for knowledge from other domains to flow into them; at the same time, knowledge from science domains, such as biomedicine-, chemistry-, and physics-related domains, can access and be accessed by other domains more easily. This study also shows that social science domains are more disunified than science domains, because three fifths of the knowledge paths from one social science domain to another require at least one science domain to serve as an intermediate. This work contributes to discussions on disciplinarity and interdisciplinarity by providing empirical analysis.
Tunnel-injected sub-260 nm ultraviolet light emitting diodes

We report on tunnel-injected deep ultraviolet light emitting diodes (UV LEDs) configured with a polarization engineered Al0.75Ga0.25 N/In0.2Ga0.8 N tunnel junction structure. Tunnel-injected UV LED structure enables n-type contacts for both bottom and top contact layers. However, achieving Ohmic contact to wide bandgap n-AlGaN layers is challenging and typically requires high temperature contact metal annealing. In this work, we adopted a compositionally graded top contact layer for non-alloyed metal contact and obtained a low contact resistance of ρc = 4.8 × 10−5 Ω cm2 on n-Al0.75Ga0.25 N. We also observed a significant reduction in the forward operation voltage from 30.9 V to 19.2 V at 1 kA/cm2 by increasing the Mg doping concentration from 6.2 × 1018 cm−3 to 1.5 × 1019 cm−3. Non-equilibrium hole injection into wide bandgap Al0.75Ga0.25 N with Eg>5.2 eV was confirmed by light emission at 257 nm. This work demonstrates the feasibility of tunneling hole injection into deep UV LEDs and provides a structura...
Non-muscle (NM) myosin heavy chain phosphorylation regulates the formation of NM myosin filaments, adhesome assembly and smooth muscle contraction.

Key points Non-muscle (NM) and smooth muscle (SM) myosin II are both expressed in smooth muscle tissues, however the role of NM myosin in SM contraction is unknown. Contractile stimulation of tracheal smooth muscle tissues stimulates phosphorylation of the NM myosin heavy chain on Ser1943 and causes NM myosin filament assembly at the SM cell cortex. Expression of a non-phosphorylatable NM myosin mutant, NM myosin S1943A, in SM tissues inhibits ACh-induced NM myosin filament assembly and SM contraction, and also inhibits the assembly of membrane adhesome complexes during contractile stimulation. NM myosin regulatory light chain (RLC) phosphorylation but not SM myosin RLC phosphorylation is regulated by RhoA GTPase during ACh stimulation, and NM RLC phosphorylation is required for NM myosin filament assembly and SM contraction. NM myosin II plays a critical role in airway SM contraction that is independent and distinct from the function of SM myosin. Abstract The molecular function of non-muscle (NM) isoforms of myosin II in smooth muscle (SM) tissues and their possible role in contraction are largely unknown. We evaluated the function of NM myosin during contractile stimulation of canine tracheal SM tissues. Stimulation with ACh caused NM myosin filament assembly, as assessed by a Triton solubility assay and a proximity ligation assay aiming to measure interactions between NM myosin monomers. ACh stimulated the phosphorylation of NM myosin heavy chain on Ser1943 in tracheal SM tissues, which can regulate NM myosin IIA filament assembly in vitro. Expression of the non-phosphorylatable mutant NM myosin S1943A in SM tissues inhibited ACh-induced endogenous NM myosin Ser1943 phosphorylation, NM myosin filament formation, the assembly of membrane adhesome complexes and tension development. The NM myosin cross-bridge cycling inhibitor blebbistatin suppressed adhesome complex assembly and SM contraction without inhibiting NM myosin Ser1943 phosphorylation or NM myosin filament assembly. RhoA inactivation selectively inhibited phosphorylation of the NM myosin regulatory light chain (RLC), NM myosin filament assembly and contraction, although it did not inhibit SM RLC phosphorylation. We conclude that the assembly and activation of NM myosin II is regulated during contractile stimulation of airway SM tissues by RhoA-mediated NM myosin RLC phosphorylation and by NM myosin heavy chain Ser1943 phosphorylation. NM myosin II actomyosin cross-bridge cycling regulates the assembly of membrane adhesome complexes that mediate the cytoskeletal processes required for tension generation. NM myosin II plays a critical role in airway SM contraction that is independent and distinct from the function of SM myosin.
Resolving the black hole causality paradox

The black hole information paradox is really a combination of two problems: the causality paradox and the entanglement problem. The causality paradox arises because in the semiclassical approximation infalling matter gets causally trapped inside its own horizon; it is therefore unable to send its information back to infinity if we disallow propagation outside the light cone. We show how the causality paradox is resolved in the fuzzball paradigm. One needs to distinguish between two kinds of Rindler spaces: (a) Rindler space obtained by choosing accelerating coordinates in Minkowski space and (b) ‘pseudo-Rindler’ space, which describes the region near the surface of a fuzzball. These two spaces differ in their vacuum fluctuations. While low energy waves propagate the same way on both spaces, infalling objects with energies $$E\gg T$$ suffer an ‘entropy enhanced tunneling’ in the pseudo-Rindler spacetime (b); this leads to the nucleation of a fuzzball before the infalling object gets trapped inside a horizon.
Precautionary Savings with Risky Assets: When Cash is Not Cash

U.S. industrial firms invest heavily in noncash, risky financial assets such as corporate debt, equity, and mortgage-backed securities. Risky assets represent 40% of firms’ financial portfolios, or 6% of total book assets. We present a formal model to assess the optimality of this behavior. Consistent with the model, risky assets are concentrated in financially unconstrained firms holding large financial portfolios, are held by poorly governed firms, and are discounted by 13% to 22% compared to safe assets. We conclude that this activity represents an unregulated asset management industry of more than $1.5 trillion, questioning the traditional boundaries of nonfinancial firms.
Exact collisional moments for plasma fluid theories

The velocity-space moments of the often troublesome nonlinear Landau collision operator are expressed exactly in terms of multi-index Hermite-polynomial moments of distribution functions. The collisional moments are shown to be generated by derivatives of two well-known functions, namely, the Rosenbluth-MacDonald-Judd-Trubnikov potentials for a Gaussian distribution. The resulting formula has a nonlinear dependency on the relative mean flow of the colliding species normalised to the root-mean-square of the corresponding thermal velocities and a bilinear dependency on densities and higher-order velocity moments of the distribution functions, with no restriction on temperature, flow, or mass ratio of the species. The result can be applied to both the classic transport theory of plasmas that relies on the Chapman-Enskog method, as well as to derive collisional fluid equations that follow Grad's moment approach. As an illustrative example, we provide the collisional ten-moment equations with exact conservatio...
Bond ETF Arbitrage Strategies and Daily Cash Flow

Bond ETFs trading at a premium (discount) to NAV experience more creations (redemptions) than those trading at parity. When these transactions occur, subsequent returns partially offset the premium or discount. These results suggest that arbitrage trading between the underlying bonds and the ETFs has a significant impact on market returns. However, in the absence of cash flow, premiums and discounts persist. The authors consider market factors that discourage arbitrage trading around premiums and discounts, and find these anomalies persist in part due to costs and uncertainty in the secondary market.
Human factors in mental healthcare: A work system analysis of a community-based program for older adults with depression and dementia

Mental healthcare is a critical but largely unexplored application domain for human factors/ergonomics. This paper reports on a work system evaluation of a home-based dementia and depression care program for older adults, the Aging Brain Care program. The Workflow Elements Model was used to guide data collection and analysis of 59 h of observation, supplemented by key informant input. We identified four actors, 37 artifacts across seven types, ten action categories, and ten outcomes including improved health and safety. Five themes emerged regarding barriers and facilitators to care delivery in the program: the centrality of relationship building; the use of adaptive workarounds; performance of duplicate work; travel and scheduling challenges; and communication-related factors. Findings offer new insight into how mental healthcare services are delivered in a community-based program and key work-related factors shaping program outcomes.
Adaptive Multicarrier OFDM SAR Signal Processing

This paper describes a solution algorithm for ultrawideband orthogonal frequency-division multiplexing (OFDM) synthetic aperture radar (SAR) signal processing. A single pointlike target is assumed, and stripmap SAR geometry is used for the analysis. The peculiarity of extracting phase history from a multicarrier return signal-such as OFDM-is in solving for the phase component using all signals' subbands in frequency domain. The least squares approach is used to find the solution form, and a grid search algorithm is used to find the phase history sample estimates. Simulation results illustrating the algorithm's performance in a 1-D cross-range profile reconstruction case, as well as in 2-D SAR imaging scenarios, are presented and discussed. It is shown that the proposed method is effective in reconstructing cross-range profiles and possesses high potential for adaptive SAR imaging while exhibiting good computational performance approximating that of range-Doppler algorithm.
On a Class of Reversible Elliptic Systems

The existence of periodic and spatially heteroclinic solutions is studied for a class of semilinear elliptic partial differential equations.
Examining national public health law to realize the global health security agenda

Where the Global Health Security Agenda (GHSA) seeks to accelerate progress toward a world safe and secure from public health emergencies, the realization of GHSA 'Action Packages' will require national governments to establish necessary legal frameworks to prevent, detect, and respond to infectious disease. By analyzing the scope and content of existing national legislation in each of the GHSA Action Packages, this comparative cross-national research has developed a framework that disaggregates the legal domains necessary to meet each Action Package target. Based upon these legal domains, this study developed an assessment tool that can identify specific attributes of national legislation. This article applies this tool to assess the legal environment in twenty Sub-Saharan African countries, examining the content of laws across the GHSA Action Packages, analyzing the legal domains necessary to implement each Action Package, and highlighting specific national laws that reflect attributes of each legal domain.
Here's My Point: Joint Pointer Architecture for Argument Mining.

In order to determine argument structure in text, one must understand how individual components of the overall argument are linked. This work presents the first neural network-based approach to link extraction in argument mining. Specifically, we propose a novel architecture that applies Pointer Network sequence-to-sequence attention modeling to structural prediction in discourse parsing tasks. We then develop a joint model that extends this architecture to simultaneously address the link extraction task and the classification of argument components. The proposed joint model achieves state-of-the-art results on two separate evaluation corpora, showing far superior performance than the previously proposed corpus-specific and heavily feature-engineered models. Furthermore, our results demonstrate that jointly optimizing for both tasks is crucial for high performance.
Entrepreneurship Rates and Health Insurance Dependent Coverage Mandates

Does the availability of health insurance for young adults affect entrepreneurial behavior? Prior research has proposed that the employer- provided system of insurance in the US may reduce entrepre...
Grand Challenges and Future Opportunities for Metal-Organic Frameworks

Metal–organic frameworks (MOFs) allow compositional and structural diversity beyond conventional solid-state materials. Continued interest in the field is justified by potential applications of exceptional breadth, ranging from gas storage and separation, which takes advantage of the inherent pores and their volume, to electronic applications, which requires precise control of electronic structure. In this Outlook we present some of the pertinent challenges that MOFs face in their conventional implementations, as well as opportunities in less traditional areas. Here the aim is to discuss select design concepts and future research goals that emphasize nuances relevant to this class of materials as a whole. Particular emphasis is placed on synthetic aspects, as they influence the potential for MOFs in gas separation, electrical conductivity, and catalytic applications.
Statistical mechanics of transport processes in active fluids: Equations of hydrodynamics

The equations of hydrodynamics including mass, linear momentum, angular momentum, and energy are derived by coarse-graining the microscopic equations of motion for systems consisting of rotary dumbbells driven by internal torques. In deriving the balance of linear momentum, we find that the symmetry of the stress tensor is broken due to the presence of non-zero torques on individual particles. The broken symmetry of the stress tensor induces internal spin in the fluid and leads us to consider the balance of internal angular momentum in addition to the usual moment of momentum. In the absence of spin, the moment of momentum is the same as the total angular momentum. In deriving the form of the balance of total angular momentum, we find the microscopic expressions for the couple stress tensor that drives the spin field. We show that the couple stress contains contributions from both intermolecular interactions and the active forces. The presence of spin leads to the idea of balance of moment of inertia due to the constant exchange of particles in a small neighborhood around a macroscopic point. We derive the associated balance of moment of inertia at the macroscale and identify the moment of inertia flux that induces its transport. Finally, we obtain the balances of total and internal energy of the active fluid and identify the sources of heat and heat fluxes in the system.
Estimation of amorphous fraction in multilevel phase-change memory cells

Abstract The effective thickness of the amorphous chalcogenide part within the active element of a phase-change memory cell is estimated through electrical measurements. Current–voltage characteristics obtained at various intermediate cell states are fitted with the trap-limited subthreshold transport model of [9] and the amorphous part thickness is then extracted. Several cell electrical measures, such as the resistance and the threshold voltage, are shown to closely relate to the estimated parameter. The results serve to further validate the trap-limited conduction model, as well as the series phase distribution hypothesis in the active layer of a phase-change memory cell.
Self-interacting scalar fields at high-temperature

We study two self-interacting scalar field theories in their high-temperature limit using path integrals on a lattice. We first discuss the formalism and recover known potentials to validate the method. We then discuss how these theories can model, in the high-temperature limit, the strong interaction and General Relativity. For the strong interaction, the model recovers the known phenomenology of the nearly static regime of heavy quarkonia. The model also exposes a possible origin for the emergence of the confinement scale from the approximately conformal Lagrangian. Aside from such possible insights, the main purpose of addressing the strong interaction here – given that more sophisticated approaches already exist – is mostly to further verify the pertinence of the model in the more complex case of General Relativity for which non-perturbative methods are not as developed. The results have important implications on the nature of Dark Matter. In particular, non-perturbative effects naturally provide flat rotation curves for disk galaxies, without need for non-baryonic matter, and explain as well other observations involving Dark Matter such as cluster dynamics or the dark mass of elliptical galaxies.
Temperature dependence of terahertz emission from silicon devices doped with boron

In this paper, we report on electrically pumped terahertz emitters based on silicon doped with boron acceptors. At cryogenic temperatures, three narrow spectral emission lines attributed to radiative transitions from p-like excited hydrogenic states to the s-like /spl Gamma//sup 8/ ground state associated with the boron dopants were observed centered around 8 THz. The spectral emission line center frequencies were in remarkable agreement with values reported from absorption measurements and theoretical calculations. The total time-resolved terahertz emission power was found to be up to 31 /spl mu/W per device facet. We have solved the rate equations describing the populations in the hydrogenic dopant states involved in the emission mechanism and derived expressions for the current pumping and temperature dependence of the emitted terahertz power, yielding excellent agreement with the experimental data. These results suggest that silicon-based terahertz emitters may be fabricated without epitaxial quantum wells. The observed temperature dependence suggests that electric field assisted thermal escape of carriers from upper hydrogenic states may be responsible for lower output powers at higher temperatures.
Clinical Aspects of Steroid Hormone Receptors in Human Renal Cell Carcinoma

A review of the role of steroid hormone receptors and hormonal dependence of renal cell carcinoma in certain patients is presented. The results of a cumulative series of estrogen, progesterone, and androgen receptor assays performed on 48 normal and malignant human renal tumor specimens are given. The detectable presence of receptor proteins in certain patients could obviate the empirical use of hormonal therapy, an issue that may be resolved through a randomized multiinstitutional trial.
Physicochemical Characterization of the Androgen Receptor From Hyperplastic Human Prostate

In this manuscript we have characterized the androgen receptor from human benign prostatic hypertrophied (BPH) tissue. BPH tissue was obtained fresh from surgery, ground, and frozen in liquid nitrogen. Tissue was homogenized in 10 mM Tes buffer (pH 7.4 at 25 degrees C) containing 0.25 M sucrose, 20 mM Na2MoO4, 12 mM monothioglycerol, and 1.5 mM EDTA. Cytosol was labeled with (3H)-R1881 (0.5-10 nM) +/- a 100-fold excess of R1881 and a 500-fold excess of triamcinolone acetonide to identify specific androgen receptor sites. An exchange assay was developed, whereby maximum binding was achieved by raising the temperature to 30 degrees C for 15 min. A high-affinity binding protein was detected (Kd = 1.3 +/- 0.8 nM) which had a binding capacity of 15 +/- 7 fmol/mg protein. Binding was specific for androgens with the following Ki (nM) values: R1881 (0.09), dihydrotestosterone (6), testosterone (50), progesterone (92), estradiol (100), epitestosterone (860), and cortisol (greater than 1,000). Under high ionic conditions the sedimentation coefficient of the receptor was 4.1 S. Higher S values were not observed in the presence of the following protein inhibitors: leupeptin (20 or 150 microM), iodoacetamide (10 mM), DFP (5 mM), PMSF (1 mM), bacitracin (0.1 mM), antipain (0.1 mM), aprotinin (1 TIU/ml). Gel filtration analysis revealed a Stokes radius of 6.5 nm. These data indicate a Mr of 120,000 and a f/fo of 2.01. The receptor eluted from a chromatofocusing column at a pH of 6.8. The receptor bound to phosphocellulose and DNA cellulose after being heat-treated for 15 min at 30 degrees C. These results suggest that BPH tissue contains an androgen receptor which is similar to receptors in other androgen-responsive tissues.
Leiomyosarcoma of the Inferior Vena Cava

A case of leiomyosarcoma of the inferior vena cava of a 46-year-old man is presented, and review of 51 cases of this type of malignant tumor is made. The biological behavior of this tumor and various treatment modalities are discussed.
Renal Cell Carcinoma Presenting as Skeletal Muscle Mass

Solitary muscle tumor, representing the first manifestation of metastatic renal cell carcinoma, is rare. A case report of a tumor mass in the left posteromedial arm, which proved to be metastatic from the right kidney, is presented. The incidence of this condition among patients presenting as a soft tissue sarcoma may be about 1%.
Meta‐Analysis of Phosphorus Loss from No‐Till Soils

Agriculture is a significant contributor to phosphorus (P) enrichment in aquatic ecosystems. No-till (NT) farming has been proposed as an alternative approach to conventional tillage (CT) in reducing soil P export, but published data have shown contrasting impacts, likely due to the interacting effects of different physical (climate region, rainfall variability, transport pathway, slope gradient) and management variables (NT duration, crop species). We conducted a meta-analysis to understand the extent to which each of these variables controls the concentration and load of different P fractions (dissolved P, particulate P) in agricultural runoff and leaching. In comparison with CT, particulate P loss was significantly lower with NT adoption (45 and 55% reduction in concentration and load, respectively), but an increase in dissolved P loss was observed. The extent of the reduction or increase, however, varied with different physical and management variables. In comparison with CT, for example, NT was not effective in reducing particulate P concentration during wet years and particulate P load on steep slopes (4-9%). Total P concentration was also similar with CT at sites under prolonged NT duration (∼10 yr) and at NT fields planted with soybean [ (L.) Merr.]. Our results underscore the need to consider the covarying physical and management factors when assessing the potential of NT farming in controlling P loss in the environment. The limited impact of NT on dissolved P loss remains a serious impediment toward harnessing the water quality benefits of this management practice.
Manifolds with quadratic curvature decay and fast volume growth

We give sufficient conditions for a noncompact Riemannian manifold, which has quadratic curvature decay, to have finite topological type with ends that are cones over spherical space forms.
Semi-Supervised Approach to Monitoring Clinical Depressive Symptoms in Social Media

With the rise of social media, millions of people are routinely expressing their moods, feelings, and daily struggles with mental health issues on social media platforms like Twitter. Unlike traditional observational cohort studies conducted through questionnaires and self-reported surveys, we explore the reliable detection of clinical depression from tweets obtained unobtrusively. Based on the analysis of tweets crawled from users with self-reported depressive symptoms in their Twitter profiles, we demonstrate the potential for detecting clinical depression symptoms which emulate the PHQ-9 questionnaire clinicians use today. Our study uses a semi-supervised statistical model to evaluate how the duration of these symptoms and their expression on Twitter (in terms of word usage patterns and topical preferences) align with the medical findings reported via the PHQ-9. Our proactive and automatic screening tool is able to identify clinical depressive symptoms with an accuracy of 68% and precision of 72%.
IDENTIFICATION AND ESTIMATION OF AUCTION MODEL WITH TWO-DIMENSIONAL UNOBSERVED HETEROGENEITY*

This article investigates the empirical importance of allowing for multidimensional sources of unobserved heterogeneity in auction models with private information. It develops the estimation procedure to recover the distribution of private information in the presence of two sources of unobserved heterogeneity. It is shown that this estimation procedure identifies components of the model and produces uniformly consistent estimators of these components. The results of the estimation with highway procurement data indicate that allowing for two-dimensional unobserved heterogeneity may significantly affect the results of estimation as well as policy-relevant instruments derived from the estimated distributions of bidders’ costs.
Examining interconnection and net metering policy for distributed generation in the United States

Following requirements of the Energy Policy Act of 2005, most U.S. states require utility companies to adopt interconnection and net metering policies, allowing customers to become prosumers who both consume and produce electricity, generating electricity using distributed renewable energy technologies, connecting to the existing electric utility grid and receiving compensation for excess electricity generation. This paper reviews existing interconnection and net metering policies instituted by investor owned utilities (IOUs) across the U.S., specifically focused on policies regulating installations of small scale, residential or Tier 1 (a term used to indicate policies applicable to smaller scale rather than larger scale, although the size at which DG systems are classified as either Tier 1 or higher tiers varies by utility). Publicly available data from each IOU reveal inconsistencies in interconnection and net metering policies, within states and even within individual companies. In addition, accurate information is often unavailable to consumers. Perhaps most importantly, results suggest that compensation for excess distributed generation often lacks transparent articulation in utility policy. The results of this study provide important insight into interconnection and net metering policies for distributed renewable energy generation, as states and utilities continue to modify interconnection and net metering policies in response to increased adoption of distributed renewable energy systems.
Radiation evaluation of the CDCLVP111-SP low voltage 1:10 LVPECL clock distributor

Single Events Effect (SEE) characterization results for LVPECL 1:10 Clock Distributor is summarized, showing very robust SEE performance up to LET eff =69.2 MeV-cm2/mg.
Assessing Consumer Demand for Georgia Lavender-Based Products

To further improve the understanding of promoting locally grown lavender, we examine consumer willingness to pay (WTP) for three lavender-based products: lavender bundles, culinary lavender, and lavender oil. We evaluate an online sample located in the southeast using a double-bounded dichotomous choice contingent valuation survey. Lavender bundles have the highest WTP, followed by oil and culinary lavender. Certain marketing factors result in higher WTP, including product familiarity, familiarity with the Georgia Grown program, and shopping frequency at farmers’ markets. This study provides a better understanding of the opportunity for small-scale farmers to market specialty crops such as lavender.
Marketplace Lending: A New Banking Paradigm?

Marketplace lending relies on screening and information production by investors, a major deviation from the traditional banking paradigm. Theoretically, the participation of sophisticated investors improves screening outcomes and also creates adverse selection among investors. In maximizing loan volume, the platform trades off these two forces. As the platform develops, it optimally increases platform prescreening intensity but decreases information provision to investors. Using novel investor-level data, we find that sophisticated investors systematically outperform, and this outperformance shrinks when the platform reduces information provision to investors. Our findings shed light on the optimal distribution of information production in this new lending model.Received August 29, 2018; editorial decision July 1, 2018 by Editor Itay Goldstein. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
A Class of Simple Rearrangements of the Alternating Harmonic Series

We present an easily defined countable family of permutations of the natural numbers for which explicit rearrangements (i.e., the sums induced by the permutations) can be computed. The digamma func...
Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State.

Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral genomes and disease etiology, many fusion proteins are arranged as trimers. Structural information for both pre-fusion and fusion-initiation states is critical for understanding virus neutralization by the host immune system. In the case of Ebola virus glycoprotein (EBOV GP) and Zika virus envelope protein (ZIKV E), pre-fusion state structures have been identified experimentally, but only partial structures of fusion-initiation states have been described. While the fusion-initiation structure is in an energetically unfavorable state that is difficult to solve experimentally, the existing structural information combined with computational approaches enabled the modeling of fusion-initiation state structures of both proteins. These structural models provide an improved understanding of four different neutralizing antibodies in the prevention of viral host entry.
Cloud-Computing Risk Disclosure and ICFR Material Weakness: The Moderating Role of Accounting Reporting Complexity

ABSTRACT Regulators have expressed concerns over management's ability to maintain effective ICFR when adopting cloud-computing services (PCAOB 2015), as well as the auditor's ability to cope with s...
A Survey of Public Opinion in the United States Regarding Uterine Transplantation.

Abstract Study Objective To evaluate the opinions and attitudes of the general public regarding uterine transplantation (UTx) in the United States. Design A cross-sectional study (Canadian Task Force classification II-2). Setting A Web-based survey. Patients A nationally representative sample of adult US residents by age and sex. Interventions A Web-based questionnaire administered in November 2016. Measurements and Main Results Respondents who supported UTx were compared with those who were opposed using log binomial regression to calculate relative risk ratios and 95% confidence intervals. Of the 1444 respondents recruited, 1337 (93%) completed the survey. Ninety respondents (6%) disagreed with the use of in vitro fertilization for any indication and were excluded. Of the remaining 1247 respondents, 977 (78%) supported and 48 (4%) opposed allowing women to undergo UTx. Respondents with higher yearly incomes and education level were more likely to agree that “taking the uterus from one person and putting it into another person is ethical.” Respondents who answered that UTx is safe for the donor, recipient, and baby were more likely to believe that UTx is an acceptable, ethical alternative to a gestational carrier. Forty-five percent of respondents believed that UTx should be covered by insurance, whereas 24% did not. Conclusion The majority of respondents in a sample of US residents support UTx, find it ethical, and believe that it is an acceptable alternative to a gestational carrier although support varies. These findings suggest that the US public is in favor of uterine transplantation as a treatment for uterine factor infertility.
Peri-adolescent drinking of ethanol and/or nicotine modulates astroglial glutamate transporters and metabotropic glutamate receptor-1 in female alcohol-preferring rats.

Abstract Impairment in glutamate neurotransmission mediates the development of dependence upon nicotine (NIC) and ethanol (EtOH). Previous work indicates that continuous access to EtOH or phasic exposure to NIC reduces expression of the glutamate transporter-1 (GLT-1) and cystine/glutamate antiporter (xCT) but not the glutamate/aspartate transporter (GLAST). Additionally, metabotropic glutamate receptors (mGluRs) expression was affected following exposure to EtOH or NIC. However, little is known about the effects of EtOH and NIC co-consumption on GLT-1, xCT, GLAST, and mGluR1 expression. In this study, peri-adolescent female alcohol preferring (P) rats were given binge-like access to water, sucrose (SUC), SUC-NIC, EtOH, or EtOH-NIC for four weeks. The present study determined the effects of these reinforcers on GLT-1, xCT, GLAST, and mGluR1 expression in the nucleus accumbens (NAc), hippocampus (HIP) and prefrontal cortex (PFC). GLT-1 and xCT expression were decreased in the NAc following both SUC-NIC and EtOH-NIC. In addition, only xCT expression was downregulated in the HIP in both of these latter groups. Also, glutathione peroxidase (GPx) activity in the HIP was reduced following SUC, SUC-NIC, EtOH, and EtOH-NIC consumption. Similar to previous work, GLAST expression was not altered in any brain region by any of the reinforcers. However, mGluR1 expression was increased in the NAc in the SUC-NIC, EtOH, and EtOH-NIC groups. These results indicate that peri-adolescent binge-like drinking of EtOH or SUC with or without NIC may exert differential effects on astroglial glutamate transporters and receptors. Our data further parallel some of the previous findings observed in adult rats.
Is American manufacturing in decline

There is a widespread view that American manufacturing is in decline. This view reflects many factors. First, real GDP growth during the current business expansion has been the weakest in the post-World War II period. Second, over the decade from 2000 to 2010 manufacturing employment declined by about 6 million. Third, persistent manufacturing trade deficits have led many observers to conclude that U.S. competitiveness has eroded. This paper discusses these arguments and suggests that, instead, U.S. manufacturing is a leading growth sector and has remained strongly competitive internationally. We show that traditional domestic economic forces adequately explain recent trends in U.S. manufacturing output and employment growth. The recent reduction in the corporate income tax rate may further boost the fortunes of the U.S. manufacturing sector, although this favorable development could be offset by a more restrictive international trade regime.
Diagnosing Glaucoma Progression with Visual Field Data Using a Spatiotemporal Boundary Detection Method.

Diagnosing glaucoma progression is critical for limiting irreversible vision loss. A common method for assessing glaucoma progression uses a longitudinal series of visual fields (VFs) acquired at r...
Wide Angle Dynamically Tunable Enhanced Infrared Absorption on Large-Area Nanopatterned Graphene.

Enhancing light-matter interaction by exciting Dirac plasmons on nanopatterned monolayer graphene is an efficient route to achieve high infrared absorption. Here, we designed and fabricated hexagonal planar arrays of nanoholes and nanodisks with and without optical cavity to excite Dirac plasmons on patterned graphene and investigate the role of plasmon lifetime, extinction cross-section, incident light polarization, angle of incident light, and pattern dimensions on the light-absorption spectra. By incorporating a high-k Al2O3 layer as the gate dielectric for dynamic electrostatic tuning of the Fermi level, we demonstrate peak absorptions of 60% and 90% for the nanohole and nanodisk patterns, respectively, in the atmospheric transparent 8–12 μm infrared imaging band with high spectral tunability. Finally, we theoretically and experimentally demonstrate angular dependence of both s- and p-polarized light absorption in monolayer graphene. Our results showcase the practical usability of low carrier mobility...
Superior structural, elastic and electronic properties of 2D titanium nitride MXenes over carbide MXenes: a comprehensive first principles study

The structural, elastic and electronic properties of two-dimensional (2D) titanium carbide/nitride based pristine (Tin+1Cn/Tin+1Nn) and functionalized MXenes (Tin+1CnT2/Tin+1NnT2, T stands for the terminal groups: –F, –O and –OH, n = 1, 2, 3) are investigated by density functional theory calculations. Carbide-based MXenes possess larger lattice constants and monolayer thicknesses than nitride-based MXenes. The in-plane Young's moduli of Tin+1Nn are larger than those of Tin+1Cn, whereas in both systems they decrease with the increase of the monolayer thickness. Cohesive energy calculations indicate that MXenes with a larger monolayer thickness have a better structural stability. Adsorption energy calculations imply that Tin+1Nn have stronger preference to adhere to the terminal groups, which suggests more active surfaces for nitride-based MXenes. More importantly, nearly free electron states are observed to exist outside the surfaces of –OH functionalized carbide/nitride based MXenes, especially in Tin+1Nn(OH)2, which provide almost perfect transmission channels without nuclear scattering for electron transport. The overall electrical conductivity of nitride-based MXenes is determined to be higher than that of carbide-based MXenes. The exceptional properties of titanium nitride-based MXenes, including strong surface adsorption, high elastic constant and Young's modulus, and good metallic conductivity, make them promising materials for catalysis and energy storage applications.
Effects of Load-Based Frequency Regulation on Distribution Network Operation

This paper examines the operation of distribution networks that have large aggregations of thermostatically controlled loads (TCLs) providing frequency regulation to the bulk power system. Specifically, we assess the prevalence of distribution network constraint violations, such as over- or under-voltages and overloading of transformers. Our goal is to determine the set of constraints that are at increased risk of being violated when TCLs provide regulation. We compare network operation in two cases: first, with TCLs operating freely; and second, with TCLs controlled to track a regulation signal. Using GridLAB-D, we run power flow simulations of five real distribution networks. Our results indicate that voltage limits are at increased risk of violation when TCLs provide regulation because of increased voltage variation. Effects on transformer aging are more nuanced and depend on the method used for dispatching TCLs. Overall, we find that, for the networks studied, the set of constraints at risk of violation is a small subset of all network constraints. Therefore, network-protecting load control algorithms may only need to consider a small set of constraints, enhancing their computational efficiency.
Tumor Treating Fields Utilization in a Glioblastoma Patient with a Preexisting Cardiac Pacemaker: The First Reported Case.

Background Tumor-treating fields (TTFs) have become an important, evidence-based modality in the treatment of glioblastoma (GBM). In patients requiring cardiac pacemakers, TTF therapy is complicated by theoretical concerns regarding possible electrical interaction between the devices. Case Description A 57-year-old man with past medical history of sick sinus syndrome requiring cardiac pacemaker implantation suffered an acute neurologic change associated with a left parieto-occipital lesion, which was found to be GBM. After completion of guideline-concordant chemoradiation, he chose to undergo TTF therapy. Because of the absence of cardiac symptoms and the theoretical risk of far-field sensing by the pacemaker of the TTF device (potentially resulting in pacemaker inhibition), the pacemaker was turned off before receiving TTF. Following TTF implementation, the patient responded well; he remains alive more than 25 months following his GBM diagnosis, exceeding the median 20.9-month survival of the recently completed phase III TTF randomized clinical trial for newly diagnosed GBM. Furthermore, he has exhibited neither cardiac morbidity nor adverse scalp reactions to TTF therapy. Conclusions The first reported case of successful TTF administration in a GBM patient with a previously implanted cardiac pacemaker may allay the concerns of neuro-oncologists, cardiologists, radiation oncologists, and all certified TTF prescribers regarding the applicability of TTF in suitable candidates with preexisting cardiac pacemakers. This case indicates that TTF therapy may be efficacious in patients with indwelling magnetic resonance image−conditional cardiac pacemakers turned to the off position and that physical removal of the pacemaker is not necessary before starting TTF.
Better loans or better borrowers ? impact of meso-credit on female-owned enterprises in Ethiopia

This paper explores the impact of large, individual-liability loans on the growth of women-owned microenterprises in Ethiopia. Traditionally, microfinance institutions in Ethiopia have primarily catered to female enterprises with group lending schemes that provide very small loans. The limitations of this model are two-fold: in addition to these micro-loans being too small in size to fuel meaningful business growth, many of the female enterprises that are targeted with these loans face binding constraints, such as concentration in lower-growth sectors, lack of alternative job opportunities, limitations on time and mobility, and restrictive gender norms. The paper investigates the impact of credit to female entrepreneurs in a novel context, by examining larger loans, provided to growth-oriented women entrepreneurs. These entrepreneurs fall in the "missing middle" or "meso-finance" segment of the financial market because their credit needs are too large for microfinance, but not large enough for commercial banks. The paper uses a propensity score matching methodology to examine the impact of loans offered to women as part of the Women Entrepreneurship Development Project, a program funded by the World Bank International Development Association, that targets growth-oriented women entrepreneurs in Ethiopia. The results suggest that large, individual-liability loans can make a significant difference in accelerating growth in the business incomes and employment levels of women-owned enterprises.
Co-Crystallization of the Anti-Cholesterol Drug Bezafibrate: Molecular Recognition of a Pharmaceutical Contaminant in the Solid State and Solution via Hydrogen Bonding

Pharmaceuticals have been found as contaminants in wastewater, causing concern for the health of aquatic life and humans. The anti-cholesterol medication bezafibrate is one such contaminant and is difficult to remove from wastewater. The lack of studies investigating the bonding behavior of bezafibrate with potential acceptor motifs prompted us to determine the types of molecules that would engage in intermolecular bonds with the drug. Although co-crystallization of bezafibrate has been previously attempted, we altered the approach by utilizing molecules containing only hydrogen-bond-acceptor sites. Here, we discuss the first successful co-crystallizations of bezafibrate, intermolecular bonding behavior, and solution-state binding studies with potential acceptor molecules. One acceptor, 4-dimethylaminopyridine, exhibits a shorter bond in the solid state, and a solution-state binding constant over 18 times higher than any other drug–acceptor pair studied here. These studies should aid in designing contamin...
The Projection Games Conjecture and the NP-Hardness of ln n-Approximating Set-Cover.

We suggest the research agenda of establishing new hardness of approximation results based on the “projection games conjecture”, i.e., an instantiation of the Sliding Scale Conjecture of Bellare, Goldwasser, Lund and Russell to projection games.
Law and the Protestant Reformation

The sixteenth-century Protestant Reformation revolutionized not only theology and the church, but also law and the state. This northern European reform movement, though divided into Lutheran, Anabaptist, Anglican, and Calvinist branches, collectively broke the international rule of the medieval Catholic Church and its canon law, and permanently splintered Western Christendom into competing nations and regions. The Reformation also triggered a massive shift of power, property, and prerogative from the church to the state. Protestant states now assumed jurisdiction over numerous subjects and persons previously governed by the medieval church, and they gave new legal form to Protestant teachings. But these new Protestant laws also drew heavily on the medieval ius commune as well as on earlier biblical and Roman jurisprudence. This chapter analyses the new legal syntheses that emerged in Protestant lands, with attention to the new laws of church-state relations, religious and civil freedom, marriage and family law, education law, social welfare law, and accompanying changes in legal and political philosophy.
Digital protectionism? Antitrust, data protection, and the EU/US transatlantic rift

EU authorities increasingly take antitrust and data protection enforcement action against US internet companies. While many believe in digital protectionism, this paper looks at the foundations of data protection and antitrust policies across the Atlantic to propose an alternative explanation based on the distinct views over how online markets work and should be regulated. Europeans associate data protection with inalienable rights, Americans treat data as an asset. Europeans use competition policy to advance personal freedom, US antitrust policy focuses on economic efficiency. These singular EU traits encourage the regulation of major internet companies. While the European mistrust of data amassing by private parties supplies political motivation to rein in on digital giants, its competition law framework provides a toolkit capable of overcoming challenges commonly present whenever regulators take antitrust enforcement action against Big Data firms. The US does not share either. This indicates that the EU/US divide over internet regulation will grow - and transatlantic tensions perilously increase. The paper concludes by arguing for an adjusted role for economic reasoning in antitrust enforcement as a way to bridge differences.
DLBCL in Hispanics: The University of Miami (UM) experience.

e19526Background: Diffuse large B cell lymphoma (DLBCL) has subtypes with different biological features and outcomes. Cell of origin classification (COO) represents 2 biologic entities - germinal c...