cssi/SciSciGPT-SciSciNet huggingface dataset:
Reliable Hierarchical Data Storage in Sensor Networks

The ability to provide reliable in-network storage while balancing the energy consumption of individual sensors is a primary concern when deploying a sensor network. The main concern with data-centric storage in sensor networks is the ability to provide reliable and load balanced storage. Energy and wireless range constraints make centralized approaches for storage impractical, and in-network data-centric solutions can be used to reduce the number of messages sent over the network. However, these solutions quickly become expensive when combined with fault- tolerance, load balancing and routing. In this paper, we present a novel data-centric storage and query routing mechanism for sensor networks. The routing mechanism is constructed upon the neighborhood information of individual sensors and is completely independent of geographical information. Our data resilient algorithm is capable of recovering from multiple simultaneous failures in the network while adaptively adjusting the load distribution of the newly generated sensor data. Comprehensive experiments on both real-world and synthetic data sets indicate that our approach is more effective and efficient than the previously proposed solutions.
Apparent viscosity of a fluid–gas mixture

The inertia free flow of a one-dimensional, isothermal fluid–gas mixture in a tube of constant radius is analyzed. The fluid is viscous, non-Newtonian, and incompressible; the gas is inviscid and compressible. Integration of the equations of continuity, momentum, and state enable the prediction of axial pressure, velocity, density, volumetric flow rate, and shear–stress profiles. Departures from corresponding profiles observed in the flow of non-Newtonian power-law fluids are evident. The apparent viscosity of the fluid–gas mixture is computed and compared to that of the fluid alone. A reduction in apparent viscosity is noted. Previously reported experimental evidence of a reduction in viscosity in a non-Newtonian fluid–gas mixture is recalled and it is claimed that the physical model presented here is capable of explaining the observed reduction in apparent viscosity.
Liver Transcriptome Profiles Associated with Strain-Specific Ehrlichia chaffeensis-Induced Hepatitis in SCID Mice

Infection of humans with Ehrlichia chaffeensis, the etiologic agent of human monocytic ehrlichiosis, can cause hepatitis of various levels of severity. When the three human isolates of E. chaffeensis, each belonging to a different genogroup, are inoculated into severe combined immunodeficiency mice, the order of severity of clinical signs and bacterial burden detected in the liver is as follows (from greatest to least severity and highest to lowest burden): strain Wakulla, followed by strain Liberty, followed by strain Arkansas. In this article, we used microarray analysis to define transcriptional profiles characteristic of the histopathological features in the mouse liver. Cytokine and chemokine profiles and their receptor profiles were strikingly different among the three strains of E. chaffeensis: gamma interferon, CCL5, CXCL1, CXCL2, CXCL7, CXCL9, interleukin 2 receptor gamma (IL2Rγ), IL21R, CCR2, and CXCR6 were highly upregulated with strain Arkansas; and tumor necrosis factor (TNF), CCL2, CCL3, CCL5, CCL6, CCL12, CCL20, CXCL2, CXCL7, CXCL9, CXCL13, TNF receptor superfamily 9 (TNFRSF9), TNFRSF13β, IL1R2, IL2Rγ, IL20Rβ, IL21R, CCR1, CCR2, and CXCR4 were highly upregulated with strain Wakulla. With strain Liberty, only CXCL13 was highly upregulated, and IL13Rα2 was downregulated. In livers infected with the Arkansas strain, monocytes/macrophages and NK cells were enriched in the granulomas and an increase in NK cell marker mRNAs was detected. Livers infected with the Wakulla strain displayed infiltration of significantly more neutrophils and an increase in neutrophil marker mRNAs. Genes commonly upregulated in liver tissue infected with the three strains are other host innate immune and inflammatory response genes, including those encoding several acute-phase proteins. Genes downregulated commonly are related to host physiologic functions. The results suggest that marked modulation of host cytokine and chemokine profiles by E. chaffeensis strains underlies the distinct host liver disease.
Novel experiment on in-cylinder desorption of fuel from the oil layer

A technique has been developed to measure the desorption and subsequent oxidation of fuel in the oil layer by spiking the oil with liquid fuel and firing the engine on gaseous fuel or motoring with air. Experiments suggest that fuel desorption is not diffusion limited above 50°C and indicated that approximately two to four percent of the cylinder oil layer is fresh oil from the sump. The increase in hydrocarbon emissions is of the order of 100 ppmC1 per 1% liquid fuel introduced into the fresh oil in a methane fired engine at mid-speed and light load conditions. Calculations indicate that fuel desorbing from oil is much more likely to produce hydrocarbon emissions than fuel emerging from crevices. © Copyright 1994 Society of Automotive Engineers, Inc.
Irish Travellers: Ethnicity, Racism Andpre-Sentence Reports:

This article examines the treatment of Irish Travellers in the criminal justice system. It provides a brief background to Irish Traveller ethnicity and then outlines the causes, extent and conseque...
A multi-GPU acceleration for 3D imaging of the prostate

Transrectal Electric Impedance Tomography (TREIT) has been proposed jointly with ultrasound (US) imaging of the prostate to enhance the standard clinical imaging. Reconstructing TREIT images involves a solution of an inverse problem. The reconstruction is based on two steps: solving and updating an estimate of the dielectric property distribution through solution of an inverse problem. In this paper we consider a multi-GPU acceleration, which will allow us to significantly speed up the solution of the inverse problem. By conducting numerical experiments we compare results in assembling the Jacobian matrix by a CPU-based multiple computational cores server, a single GPU acceleration, and eventually a multi-GPU.
Relating the Structure, Activity, and Physical Properties of Ultrashort-Acting Benzodiazepine Receptor Agonists

The ultrashort-acting benzodiazepine (USA BZD) agonists reported previously have been structurally modified to improve aqueous solubility. Lactam-to-amidine modifications, replacement of the C5-haloaryl ring, and annulation of heterocycles are presented. These analogues retain BZD receptor potency and full agonism profiles.
Efficacy of combined use of intraarticular and intravenous tranexamic acid in total knee arthroplasty.

Tranexamic acid (TXA) has come to light as an effective method to decrease blood loss and transfusion rates in total knee arthroplasty (TKA) without increasing the risk of thromboembolic events (TEE) (1). Many initial studies utilized intravenous (IV) TXA and more recently topical TXA has also been shown to be effective (2,3). In these studies, various dosing regimens have been used for both IV and topical TXA. Some have attempted to find the most beneficial regimen, demonstrating better results with two IV doses compared to a single IV dose (4,5). Others have compared various topical regimens to IV regimens, often comparing single topical doses to one or two IV doses (6-8). These have often shown similar results between IV and topical TXA; however, comparison is difficult due to variance in the regimens used (quantity of TXA, number of doses, route of topical administration). Our standard practice is to administer one gram IV prior to incision and one gram IV at initiation of closure. This provides an effective, easily reproducible routine for the entire surgical team.
Normative Values for Isometric Muscle Force Measurements Obtained With Hand-held Dynamometers

Background and Purpose. The extent of a patient's impairment can be established by comparing measurements of that patient's performance with normative values obtained from apparently unimpaired individuals. Only a few studies have described normative values for muscle strength measured by hand-held dynamometry. The purpose of this study of older adults, therefore, was to obtain normative values of maximum voluntary isometric force using hand-held dynamometers. Subjects. One hundred fifty-six asymptomatic adults (77 men, 70 women) participated in this study. The subjects' mean age was 64.4 years (SD=8.3, range=50–79). The male subjects' mean age was 64.5 years (SD=8.4, range=50–79), and the female subjects' mean age was 64.3 years (SD=8.2, range=50–79). Methods. Gender, age, dominant side, height, weight, and activity level were recorded. Eight upper-extremity movements (shoulder flexion, extension, abduction, and medial and lateral rotation; elbow flexion and extension; and wrist extension) and five lower-extremity movements (hip flexion and abduction, knee flexion and extension, and ankle dorsiflexion) were resisted by one of three experienced testers using a strain-gauge hand-held dynamometer. Results. Gender, age, and weight were identified as independent predictors of force for all muscle actions on both the dominant and nondominant sides. These variables were used, therefore, to create regression equations and normative values for the force of each muscle action. Conclusion and Discussion. The reference values provided may allow clinicians who follow the described testing protocol to estimate the severity of force-generating impairments in patients aged 50 to 79 years.
Community conflict over arena and stadium funding : Competitive framing, social action, and the socio-spatial perspective

Abstract This is a study of community conflict over an attempt by the power elite at urban redevelopment through the construction of a stadium and an arena at public expense. The facilities would be for the use and profit of private sector hockey and soccer franchises. Our analysis of the conflict is guided by three theoretical perspectives: competitive framing analysis, social action theory, and the socio-spatial perspective. In this paper our primary focus is on frame analysis as we discuss the contested referendum for public funding for the planned sports facilities. Our goal is to determine why the economically and politically powerful pro-development forces lost the vote to a lightly funded and loose coalition of ideologically diverse citizen groups. We especially focus on the role in the conflict of the contentious issue framing and counterframing activities engaged in by the two combatant sides. In our discussion we add insights from the socio-spatial and social action perspectives to those from fr...
Docutek: Past and future

Dr. Philip R. Kesten, a physics professor at Santa Clara University in Santa Clara, California, co-founded Docutek Information Systems, the parent company for the popular electronic reserves product ERes, in the mid 1990s. This article looks at how and why Dr. Kesten became involved with electronic reserves and where the company hopes to go with its product.
Black Vine Weevil (Coleoptera: Curculionidae) Feeding and Oviposition on Leaves of Weevil-resistant and -susceptible Strawberry Clones Presented in Various Quantities

Adult black vine weevils, Otiorhynchus sulcatus (F.), were fed ‘Totem’ strawberry or clone CL-5 of the wild beach strawberry, Fragarta chiloensis (L.) Duchesne weekly for 14 weeks after eclosion. Amounts of leaf provided were varied to give a food supply ranging from insufficient to abundant. In general, amount of leaf eaten increased, preoviposition period decreased, and number of eggs laid increased as leaf disk size increased. With equal food supply, feeding was less, preoviposition period was longer, and oviposition was less on CL-5 than on ‘Totem’. This indicated that resistance is due in part to less feeding on CL-5 than on ‘Totem’. However, preoviposition period was longer and fewer eggs were laid on CL-5 than on ‘Totem’ even when daily food intake was equal, indicating that factors in addition to antixenosis are involved in resistance of CL-5 to adult black vine weevil.
Optical properties of nanostructured carbon and gold nanoparticle hybrids

We report simulation of optical properties of hybrid geometry comprised of multilayer graphene shell encapsulated gold nanoparticles loaded with carbon nanotubes. The discrete dipole approximation (DDA) method was employed. The results indicated that the optical properties of encapsulated gold nanoparticles were not suppressed by the carbon material coating. Furthermore, low scattering effects were also observed. The simulation method helped visualize the near-surface normalized electric field, which is directly related to the intensity of hot spots on the surface of these hybrid nanoarchitectures.
Effect of glucose and biotin on the growth and sporulation of Fusarium species, especially pathogenic and nonpathogenic isolates of Fusarium oxysporum

Fusarium spp. often initiate growth slowly on high glucose media in the absence of added biotin. Among the isolates of F. oxysporum studied, two types were apparent: low sporulating and high sporulating cultures on agar media. Saprobic isolates of F. oxyspo? rum found in sandy soils usually grew slower than the wilt pathogens from these soils. Within the group of isolates of F. oxysporum formae speciales which cause wilt in host plants, there were two distinct cultural types that were consistently isolated from all infested field soils and from infected plants in each field ob? served. These two types differed in their degree of sporulation and growth on high glucose agar medium without added biotin; they also could be distinguished based on whether or not they produced a substance easily detected by its odor.
Effect of Gramicidin on Metabolism of Bovine Spermatozoa.

SummaryCrude and purified gramicidin after initial stimulation inhibits the oxygen consumption of bovine spermatozoa completely in Ringer phosphate of acid pH and renders the cells immobile. By the use of sufficiently small amounts only stimulation is observed during the period of the experiment. In alkaline phosphate buffer only the increase of oxygen consumption is noted. However, in Ringer bicarbonate medium of the same pH, the respiration again is greatly inhibited; aerobic as well as anaerobic glycolysis are depressed on the average 40% and the motility of the spermatozoa is markedly impaired. Tyrocidine, in the concentrations studied, caused a small reduction in the oxygen uptake and the glycolysis.
Altered Guanine Nucleotide Protein Function: Potential Role in Endotoxin Tolerance

Endotoxin stimulates macrophages to synthesize and release a number of monokines including tumor necrosis factor (TNF), colony stimulating factor, platelet-activating factor, interleukin-1 (IL-1) and arachidonic acid metabolites [1–8]. In recent years arachidonic acid metabolites or eicosanoids, a group of inflammatory mediators, have generated considerable interest [9–14]. Arachidonic acid is esterified in the 2-position of specific cellular phospholipids including phosphatidylcholine (PC), phosphatidyl-ethanolamine (PE), and phosphatidylinositol (PI) [15–19]. The generation of free arachidonic acid from phospholipids is thought to be a rate-limiting step in the formation of arachidonic acid metabolites [20]. Endotoxin-stimulated cells mobilize their phospholipids through at least two major pathways [21]. In the first pathway, phospholipase C cleaves phosphatidylinositol 4,5-biphosphate, yielding inositol-1,4,5-triphosphate (IP3) and 1,2-diacylglycerol, both of which are second messengers [22–25]. IP3 mobilizes cytoplasmic calcium while 1,2-diacylglycerol stimulates protein kinase C [26–28]. A separate diglyceride lipase cleaves arachidonic acid from the diacylglycerol molecule [29, 30]. In the second pathway, phospholipase A2 (PLA2) directly releases arachidonic acid and other unsaturated fatty acids from phospholipids including PC, PE, and PI.
Stretch-dependent regulation of atrial peptide synthesis and secretion in cultured atrial cardiocytes.

We have developed a novel system to study stretch-dependent secretion of atrial natriuretic peptide (ANP) using cultured neonatal rat atriocytes in vitro. Application of tension (i.e., 2 sequential stretches) to cells grown on a flexible culture surface effected a dose-dependent increase in immunoreactive (ir) ANP release into the medium. Analysis of atriocyte cytoplasmic RNA 24 h poststretch revealed an increase in ANP mRNA levels of about ninefold relative to the unstretched controls. Medium ATP levels, measured as an index of cellular damage, were similar in control and stretched cells. Furthermore, cooling the cultures to 0 degrees C suppressed both basal as well as stretch-stimulated release. These findings argue against cellular damage and nonspecific release of irANP as an explanation for the increase in medium immunoreactivity. Stretch was incapable of amplifying the secretory response to prostaglandin F2 alpha, suggesting possible overlap in the pathways whereby these stimuli effect release of the peptide. The calcium channel blocker verapamil had no effect on stretch-dependent irANP release, whereas calmidzolium, a calmodulin inhibitor, suppressed basal as well as stretch-dependent secretion, implying a potentially important relationship between intracellular calcium metabolism and irANP release.
Surgical adjuvant therapy for lung cancer.

Trials have shown the effect of immunotherapy for lung cancer to be marginal, but intralesional BCG therapy holds considerable promise. Past studies evaluating chemotherapy have not been encouraging, but new combination chemotherapeutic regimens offer considerable hope. Several trials are in progress to evaluate preoperative chemotherapy in advanced resectable disease and postoperative chemotherapy following total resection; although preliminary results are encouraging, it is too early to make a definitive statement.
DC-SIGN Mediated Dengue Virus Entry into Cells

DC-SIGN (a single-pass, C-type lectin, transmembrane protein) is a receptor for dengue virus (DENV) and variety of other pathogens. It exists in small clusters on the plasma membranes of dendritic and other immune cells. Using NIH3T3 cells that express full length DC-SIGN or a mutant form lacking the cytoplasmic tail as well as primary human immature dendritic cells, we investigated DENV binding, surface transport, endocytosis and infection. We employed confocal microscopy, super-resolution imaging and large-scale single particle tracking. After binding, the virus/receptor complexes co-migrate to clathrin coated pits where the complexes are endocytosed followed by release of the viral genome for replication. Suprisingly, dengue binding, even to a few DC-SIGN clusters, induces a global cellular response in which both loaded and unloaded DC-SIGN clusters exhibit dramatically increased lateral mobility, possibly to enhance encounters with coated pits. In addition, a small but significant fraction of DC-SIGN clusters in the plasma membrane undergo rapid, microtubule-based directed transport towards the cell center at velocities which can exceed 1μm/s. Since the measured velocities are increased after dengue binding, this activity may be required to bring captured pathogens from the leading margins back to perinuclear zone for processing by dendritic cells. A controversy exists as to whether DC-SIGN functions simply as an attachment factor for dengue viruses or whether it plays additional roles in viral entry. The absence of the DC-SIGN cytoplasmic region reduced both dengue binding and endocytosis. However, infection still occurred, albeit reduced, suggesting that DC-SIGN must be able to act in concert with a co-receptor containing cell entry motifs. Supported by NIH GM41402.
How to Improve Adolescent Stress Responses: Insights From Integrating Implicit Theories of Personality and Biopsychosocial Models

This research integrated implicit theories of personality and the biopsychosocial model of challenge and threat, hypothesizing that adolescents would be more likely to conclude that they can meet the demands of an evaluative social situation when they were taught that people have the potential to change their socially relevant traits. In Study 1 (N = 60), high school students were assigned to an incremental-theory-of-personality or a control condition and then given a social-stress task. Relative to control participants, incremental-theory participants exhibited improved stress appraisals, more adaptive neuroendocrine and cardiovascular responses, and better performance outcomes. In Study 2 (N = 205), we used a daily-diary intervention to test high school students' stress reactivity outside the laboratory. Threat appraisals (Days 5-9 after intervention) and neuroendocrine responses (Days 8 and 9 after intervention only) were unrelated to the intensity of daily stressors when adolescents received the incremental-theory intervention. Students who received the intervention also had better grades over freshman year than those who did not. These findings offer new avenues for improving theories of adolescent stress and coping.
Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo.

Summary The importance of mitochondria for neuronal function is evident by the large number of neurodegenerative diseases that have been associated with a disruption of mitochondrial function or transport (reviewed in [1, 2]). Mitochondria are essential for proper biological function as a result of their ability to produce ATP through oxidative phosphorylation, buffer cytoplasmic calcium, regulate lipid biosynthesis, and trigger apoptosis (reviewed in [2]). Efficient transport of mitochondria is thought to be particularly important in neurons in light of their compartmentalization, length of axonal processes, and high-energy requirements (reviewed in [3]). However, the majority of these results were obtained using short-term, in vitro neuronal culture models, and very little is currently known about mitochondrial dynamics in mature axons of the mammalian CNS in vitro or in vivo. Furthermore, recent evidence has demonstrated that mitochondrial immobilization at specific points along the axon, such as presynaptic boutons, play critical roles in axon morphogenesis [4, 5]. We report that as cortical axons mature, motility of mitochondria (but not other cargoes) is dramatically reduced and this coincides with increased localization to presynaptic sites. We also demonstrate using photo-conversion that in vitro mature axons display surprisingly limited long-range mitochondrial transport. Finally, using in vivo two-photon microscopy in anesthetized or awake-behaving mice, we document for the first time that mitochondrial motility is also remarkably low in distal cortical axons in vivo. These results argue that mitochondrial immobilization and presynaptic localization are important hallmarks of mature CNS axons both in vitro and in vivo.
On the Metamorphoses of Transcendental Reduction: Merleau-Ponty and “the Adventures of Constitutive Analysis.”

Invocations of Merleau-Ponty’s claim concerning the incompleteness that accompanies the phenomenological reduction have had a long and somewhat contentious history. In this paper I will further explore the implications of Merleau-Ponty’s claim and the itinerary from which it emerges. From the Structure of Behaviour onward, he argued that consciousness is not a transcendental presupposition but an achievement that emerges from and transforms the labor of our rational practices (1963: 162, 176). Phenomenological theory rightly argued for the centrality of the experience of the reduction, albeit too often by mistakenly bestowing immanence upon it. Statically regarded, the reduction may involve an ‘act’ but it is also a Stiftung, and thus a performative, one that Merleau-Ponty claims involves an institution and an acquisition: as he puts it quite simply, it is learned (s’apprenent) (1964: 179). The reduction involves intuition but it is also a conceptual practice involving “a multitude of operations”, a symbolic matrix always articulated through internal transformations. Finally the reduction is an experience but it is always a sequence “gradually effected” and thus an embodied history (1968: 173). It results then not in the Spinozist Habemus ideam verum, but as “The Philosopher and His Shadow” rightly concludes, an “artifact” (1964: 180). For Merleau-Ponty, all this forced the recognition of the “internal difficulty” (interne difficulte) in the reduction theorized through the concept of a constituting consciousness. Moreover, this not an anthropological claim about a faculty or finitude, but a claim about the rationality, the “metamorphosis” and “coherent deformation” of its experience, an “ordered sequence of steps” that “could not possibly reach completion in the intellectual possession of a noema” (1964: 165). It is not simply en presence, in the static relation of presence that phenomenology achieves justification. For Merleau-Ponty, its experience is not unrevisable, nor immanently completable: instead it is only through the ordered steps of its history that it acquires sufficiency.
A Completeness Theorem for Entire Functions

if f(z) = exp z, then f n = P n f, where {P n } is a sequence of polynomials-we shall call P n the n-th Stirling polynomial.
Effects of Anion Mobility on Electrochemical Behaviors of Lithium–Sulfur Batteries

The electrolyte is a crucial component of lithium–sulfur (Li–S) batteries, as it controls polysulfide dissolution, charge shuttling processes, and solid-electrolyte interphase (SEI) layer formation. Experimentally, the overall performance of Li–S batteries varies with choice of solvent system and Li-salt used in the electrolyte, and a lack of predictive understanding about the effects of individual electrolyte components inhibits the rational design of electrolytes for Li–S batteries. Here we analyze the role of the counteranions of common Li salts (such as TfO–, FSI–, TFSI–, and TDI–) when dissolved in DOL/DME (1:1 by vol.) for use in Li–S batteries. The evolution of ion–ion and ion–solvent interactions due to various anions was analyzed using 17O NMR and pulsed-field gradient (PFG) NMR and then correlated with electrochemical performance in Li–S cells. These data reveal that the formation of the passivation layer on the anode and the loss of active materials from the cathode (evidenced by polysulfide di...
Nonlinear control of aircraft

In recent work at the NASA Ames Research Center, transformations of nonlinear systems have been used to design automatic flight controllers for vertical and short take off aircraft. Under the assumption that a nonlinear system can be mapped to a controllable linear system, we motivate by partial differential equations a method to construct approximate transformations in cases where exact ones cannot be found. We also present an application of the design theory to a rotorcraft, the UH-1H helicopter.
The Hormonal Responses to Competition and Their Behavioral Significance

By far, the vast majority of studies concerned with the relationship between hormones and the behaviors that occur in competitive situations—the agonistic behaviors—have been directed toward explaining the ways in which hormones affect those behaviors. However, that relationship really is bidirectional. Not only do hormones affect aggressive and submissive responses, but experiencing agonistic interactions alters the individual’s endocrine characteristics. Those hormonal responses to agonistic experiences are the topic of this discussion.
Alleviating Hydrogen Plasma Damage to Amorphous/Crystalline Silicon Interface Passivation

Hydrogen plasma treatment is used to enhance the interface passivation of amorphous/crystalline silicon (a-Si:H/cSi) heterojunctions, but prolonged hydrogen plasma treatment can cause adverse passivation damage. Although hydrogen plasma etching of the a-Si:H layer has been proposed as a plausible explanation, we find that hydrogen plasma damage to the c-Si substrate could be more important. We cap a-Si:H passivation layers with a ~2.5-nm-thick silicon oxide layer to preserve the a-Si:H/c-Si interface and find that severe hydrogen plasma damage is greatly alleviated (slowed down by a factor of 7-10) while the hydrogen still penetrates into the underlying aSi:H layer for interface passivation.
Synthesis, Conformational Analysis, and Evaluation of the Multidrug Resistance-Reversing Activity of the Triamide and Proline Analogs of Hapalosin

Four analogs were synthesized which have trans-4-hydroxyl-l−proline replacing the N-Me-l-phenylalanine moiety in hapalosin. The triamide analog of hapalosin containing two secondary amide bonds in lieu of the two ester bonds in hapalosin was also synthesized. Conformations of hapalosin, the triamide analog, and two of the four proline analogs in chloroform were calculated utilizing distance constraints between NOESY-correlated protons. The lowest-energy, distance-constrained conformation of hapalosin is similar to that of the triamide analog and does not differ substantially from that of the two proline analogs. All conformations have an s-cis tertiary amide bond. The analogs' ability to reverse P-glycoprotein-mediated multidrug resistance was evaluated in cytotoxicity and drug accumulation assays using MCF-7/ADR cells which overexpress P-glycoprotein. Two of the proline analogs are more potent than hapalosin (which has a similar activity as verapamil) whereas the other two proline analogs and the triamid...
Scouringrush (Equisetum spp.) control in dryland winter wheat

The adoption of chemical fallow rotations in Pacific Northwest dryland winter wheat production has caused a weed species composition shift in which scouringrush has established in production fields. Thus, there has been interest in identifying herbicides that effectively control scouringrush in winter wheat–chemical fallow cropping systems. Field experiments were established in growers’ fields near Reardan, WA, in 2014, and The Dalles, OR, in 2015. Ten herbicide treatments were applied to mowed and nonmowed plots during chemical fallow rotations. Scouringrush stem densities were quantified the following spring and after wheat harvest at both locations. Chlorsulfuron plus MCPA-ester resulted in nearly 100% control of scouringrush through wheat harvest. Before herbicide application, mowing had no effect on herbicide efficacy. We conclude chlorsulfuron plus MCPA-ester is a commercially acceptable treatment for smooth and intermediate scouringrush control in winter wheat–chemical fallow cropping systems; however, the lack of a positive yield response when scouringrushes were controlled should factor into management decisions.
sin2θefflept and MW(indirect) extracted from 9 fb−1 μ+μ− event sample at CDF

We report on the extraction of $$\sin^2\theta^{\rm lept}_{\rm eff}$$ and indirect measurement of the mass of the W boson from the forward-backward asymmetry of $$\mu^+\mu^-$$ events in the $Z$ boson mass region. The data sample collected by the CDF detector corresponds to the full 9 fb$$^{-1}$$ run II sample. We measure $$\sin^2 \theta^{\rm lept}_{\rm eff} = 0.2315 \pm 0.0010$$, $$ \sin^2 \theta_W = 0.2233 \pm 0.0009$$ and $$M_W ({\rm indirect}) = 80.365 \pm 0.047 \;{\rm GeV}/c^2$$, where each uncertainty includes both statistical and systematic contributions. Comparison with the results of the D0 collaboration are presented.
Fluorescence in-situ hybridisation for TP63 rearrangements in T cell lymphomas: single-site experience of 470 patients and implications for clinical testing.

Aims The aims of this study were to review our 5-year experience with clinical FISH testing for TP63 rearrangements using both TP63 break-apart (BAP) and TBL1XR1/TP63 dual-fusion (D-FISH) probes to evaluate the frequency of TP63 rearrangements and the distribution of TBL1XR1 vs. alternate partner loci, and to assess whether both probe sets are necessary in all cases undergoing FISH testing. Methods and results A retrospective review of the Mayo Clinic cytogenetic database identified 470 patients evaluated by FISH testing for TP63 rearrangements in formalin-fixed paraffin-embedded (FFPE) tissue using both BAP and D-FISH probes. Of these, 25 (5.3%) had TP63 rearrangements. All samples were being investigated for anaplastic large-cell lymphoma or other T cell lymphoma subtypes. A TBL1XR1 partner was identified by D-FISH in 12 (48%) of 25 cases. All cases positive by TBL1XR1/TP63 D-FISH were also positive by TP63 BAP FISH. Conclusion This is the largest series of TP63 rearrangements to date. The frequency of positive results among cases referred to a large reference laboratory for TP63 FISH testing was 5.3%. Approximately half of TP63 rearrangements have a TBL1XR1 partner. TP63 BAP FISH testing is sufficient for up-front testing of FFPE tissue samples. However, because of the genomic proximity of the TP63 and TBL1XR1 loci, we recommend reflex TBL1XR1/TP63 D-FISH testing in positive and equivocal cases.
Near static strain measurement with piezoelectric films

Abstract A fundamental challenge that prevents the implementation of piezoelectric sensors for measuring extremely low frequency (
Reaction cross sections for $sup 16$O with Fe, Ni, Ge, and Zr

Relative excitation functions for the total neutron production and total charged-particle (proton, alpha ) production above 2 MeV fom /sup 16/O e, Ni, Ge, and Zr have been measured at theta /sub lab = 90 deg and in the bombarding energy range from 30 to 60 MeV. For the most part, the onset of reaction product yields agrees well with the barrier heights as determined from /sup 16/O elastic scattering. Absolute measurements for light charged-particle production the bombarding number of emitted charged particles calculated from Weisskopf-Ewing evaporation theory and with the effects of angular momentum included, the results when compared to optical-model reaction cross sections suggest a moment of inertia of one half the rigid-body value. (auth)
Shepherding: A concept analysis

The purpose of this analysis was to explore the concept of shepherding as it applies to nursing. Shepherding is a term used in chaplaincy literature to describe the guidance and protection a chaplain offers. While this term may be appropriate to the relational work of nurses, it has yet to be defined in the nursing literature. Walker and Avant's eight-step method for concept development was utilized. An electronic search using "shepherd/shepherding and nursing or health or inpatient" was performed in eight databases related to nursing, medicine, health, social sciences, and chaplaincy. Scholarly articles, in English, with substantive references to shepherding were included. Four defining attributes related to shepherding were identified: relational interaction, safety and comfort, reciprocal guidance, and transformation through possibilities and actualization. The operational definition of shepherding was thus identified as a relational interaction between the nurse and a patient or family during a transformational crisis. The nurse accompanies the patient, ensuring safety, and comfort and, through reciprocal guidance, the nurse supports the patient to understand possibilities and actualize possibilities based on the patient's preferences.
Therapeutic hypothermia and mortality in the intensive care unit: systematic review and meta-analysis.

Objective: Therapeutic hypothermia (TH) is defined as the designed reduction of the human body's core temperature to 32 degreesC-35 degreesC for a period of 24-48 hours. TH has been studied extensively in many diseases related to critical care illness. This metaanalysis assesses the effect of TH on mortality across different indications in medical, neurological and cardiothoracic care. Data sources: The online databases Embase, Ovid MEDLINE, TRIP and CINAHL were searched for eligible studies published between 1940 and October 2018. Study selection: Randomised clinical trials of induced TH in adults for any indication. Data extraction: Information about baseline characteristics of patients, mortality outcomes, cooling strategy and target temperature achieved in hypothermia and normothermia groups was collected. Data synthesis: Eighty studies, with a total of 13 418 patients, were included in this meta-analysis: 22 studies for traumatic brain injury, six studies for stroke, five studies for out-of-hospital cardiac arrest (OHCA), 34 studies for intraoperative cardiopulmonary bypass, and 13 studies for other diseases. A total of 6901 patients (51.4%) were randomly allocated to the TH group and 6517 patients (48.6%) were randomised to the normothermia control group. The unadjusted analysis showed no significant difference in mortality across different critical care illnesses. However, after adjusting for population, gender, age and temperature, only the OHCA group showed a small statistically significant difference favouring TH, but this had a questionable clinical significance. Conclusions: This meta-analysis suggests that after decades of extensive research, TH has yet to show a beneficial effect on mortality across different critical care diseases.
My True Self is Better Than Yours: Comparative Bias in True Self Judgments:

Researchers have assumed that people judge their own true selves, or their authentic and fundamental nature, to be no better than that of others. This assumption conflicts with self-enhancement perspectives, and with studies on comparative biases in self and social judgment, which assume that people tend to view their characteristics and life prospects more favorably than those of others. The five studies in this article demonstrate that comparative bias operates in self versus other true self comparisons, both with regard to traits (Studies 1-3), and morally relevant behaviors (Studies 4 and 5). Implications for the true and authentic self constructs are discussed.
Distribution Network Neutral Arc Suppression Coil Parallel Adjustable Resistance and Control Strategy

Distribution network arc suppression coil parallel resistance grounding has the advantages of both arc suppression coil grounding mode and resistance grounding mode. However, the grounding mode of arc suppression coil parallel resistance is not pieced together simply with the two grounding modes. There are some technology problems needed to study deeply. These are studied for arc suppression coil parallel resistance grounding mode in the paper, including resistance value, put into time and run time of the resistance and so on. Based on protection tripping and isolating fault quickly after single phase grounding fault, and considering to sensitivity of protection and personal safety (touch voltage and step voltage), these control strategies are put forward, which include resistance value of parallel resistance, using adjustable resistance technology proposal and its adjustable range, put into time and run time of the resistance, and the fault line selection characteristic quantity.
A 68-Year-Old Man With Skin Rash and a Pleural Effusion.

Case Presentation A 68-year-old man developed an erythematous, papular, pruritic rash on his right thigh 1 month prior to presentation. It subsequently spread to his other extremities and trunk. He also endorsed fevers of > 38.3°C, night sweats, fatigue, shortness of breath, and a dry cough. He was prescribed triamcinolone 0.1% cream for his rash and azithromycin for presumed community-acquired pneumonia, with no improvement in symptoms. He had a history of relapsing polychondritis for which he was prescribed infliximab and low-dose prednisone. He had never smoked tobacco, did not use alcohol or illicit substances, and had no significant travel history.
Opinion: We have been in lockdown, but deforestation has not

Edilson Consuelo de Oliveira has regained his sense of taste and smell, so he has finally been able to enjoy a plate of pirapitinga, his favorite fish in all the Amazon. Before contracting coronavirus disease 2019 (COVID-19), Edilson had been in lockdown on a small farm outside of Rio Branco, the capital of Acre state in Brazil, but in early June a nephew came to visit from the city, bringing a dry cough. Edilson was hospitalized for only two days and felt ill for two weeks; since then he has been recovering back on the farm. It’s lucky for him and for the Amazon, because Edilson is a “super-mateiro,” or master woodsman, one of a handful in that vast region (see Fig. 1). Edilson is something of a taxonomic shaman, as he can name hundreds of species of Amazonian trees on sight and is familiar with several thousand more. Fig. 1. Although the pandemic has put much of nature at a distance, Douglas Daly ( Left ) asks what field-based researchers can be doing now, what should be done when it’s again safe to travel to study sites, and how to best train new cohorts of researchers and super-mateiros like Edilson de Oliveira ( Right ). Rarities like Edilson are highly sought after by researchers, forest concessions, and conservationists. That is because any valid effort to conserve or manage biodiverse tropical forests requires that we know their species composition. However, now that the pandemic has put much of nature at a distance, field-based biologists have had to take stock: What can we be doing now? What must we do when the coast is clearer and we can safely travel to our study sites once again? Most importantly, why must we never let up in our efforts to buttress conservation programs and train new cohorts of … [↵][1]1Email: ddaly{at}nybg.org. [1]: #xref-corresp-1-1
Malignant Hypertension and Osteoporotic Fractures in a 15-year-old Boy.

1. Salaheddin H. Elrokhsi, MD* 2. Rachel Baumann Manzo, MD† 3. Mark D. Wheeler, MD† 4. Rajan Senguttuvan, MD‡ 5. Cindy N. Chin, MD† 1. *University of Nebraska Medical Center, Omaha, NE 2. †University of Arizona, Tucson, AZ 3. ‡Driscoll Children’s Hospital, Corpus Christi, TX A 15-year-old boy with years of poor linear growth presents to the emergency department (ED) with 1 day of headache, blurry vision, and intermittent palpitations associated with elevated blood pressure (BP) (home BP using his mother’s BP monitor is 181/133 mm Hg). On presentation he denies chest or abdominal pain, nausea, syncope, diplopia, dysuria, numbness, and weakness. BP at his pediatrician’s office on the day before ED presentation was 190/110 mm Hg. Several weeks earlier the patient had reestablished care with his pediatrician after a lapse of 4 years. He was seen for back pain after 2 falls from his skateboard with documented BP of 102/60 mm Hg. At that visit his weight was 98.3 lb (44.6 kg) (3.6 percentile for age), height was 57.6 in (146.3 cm) (0.1 percentile for age), and BMI was 20.8 (58th percentile for age). At age 11.5 years his weight had been 100 lb (45.4 kg) (77th percentile for age) and height had been 57 in (144.8 cm) (39th percentile for age). On examination in the ED the patient’s vital signs are notable for a pulse of 142 beats/min and BP of 193/149 mm Hg, assessed in the left upper extremity. Repeated BPs in the right upper and lower extremities are similarly elevated. The patient has flushed cheeks, bruising of the bilateral lower extremities, and Tanner II genital development. His neurologic examination findings are normal. Aside from tachycardia and hypertension, his cardiovascular examination findings are normal. His abdomen is soft, nontender, and nondistended, without palpable masses. He has truncal obesity but no abdominal striae. Initial laboratory evaluation is significant for an …
Investigation of Copper/Stainless Steel Multi-Metallic Materials Fabricated by Laser Metal Deposition

Abstract The feasibility of fabricating a single component with a copper and stainless steel multi-material structure can broaden its functional properties and offer significant value in engineering design. In an effort to join copper with 304L stainless steel (SS304L) using the laser metal deposition technique, pure copper was deposited on SS304L both directly and via interlayers of a nickel-based alloy Deloro 22 (D22). The microstructure, elemental distribution, bonding strength, microhardness profile, and thermal conductivity/diffusivity of the multi-metallic structures were investigated. The transition zone of the Cu-SS direct joint shows numerous SS304L globules and separated Cu-rich and Fe-rich islands. Tensile testing of the Cu-SS shows poor bonding strength. By adding D22 interlayers, a well bonded and defect-free Cu-D22-SS structure was achieved. Evidence of strong bonding at the Cu-D22 and D22-SS was obtained by tensile testing where samples broke in either the copper or D22 regions. The Cu-D22-SS results in a hardness of 228.7 ± 19.5 HV at the D22 layers. Ascending to the copper layers, a gradual drop of hardness to a steady value of 52.9–56.1 HV was observed. The theoretical prediction shows there is a ~100% increase in thermal conductivity and a ~370% increase in thermal diffusivity of the Cu-D22-SS system when compared with pure SS304L.
I Resent that I Have Helped you! A Qualitative Study of Sources and Consequences of Resentment of Helping

Drawing upon conservation of resources (COR) theory, prior research has shown how helping behavior leads to a depleted condition experienced by the helper. It, however, remains ambiguous regarding why some helping situations allow the helper to have positive experiences while other situations lead to depleted experiences? Utilizing the grounded theory approach with inductive reasoning, we find two broad categories of sources leading to resentment of helping, including characteristics of the recipient and performance-related threats. Moreover, we propose that when resentment of helping is experienced, helping discontinuation is likely to occur. Furthermore, we theorize that forgiveness and organizational rewards moderate the relationship between resentment of helping and helping discontinuation. Theoretical and managerial implications are also discussed.
Gender in Emergency Services: Foundations for Greater Equity in Professional Codes of Ethics

The lack of gender equity in the public sector is a critical issue, especially for emergency services. We explore the gendered nature of firefighting and policing at both professional and organizat...
Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity

Obesity-induced insulin resistance is a risk factor for diabetes and cardiovascular disease. However, the mechanisms underlying endothelial senescence in obesity, and how it impacts obesity-induced insulin resistance remain incompletely understood. In this study, transcriptome analysis revealed that the long non-coding RNA (lncRNA) Maternally expressed gene 3 (Meg3) is one of the top differentially expressed lncRNAs in the vascular endothelium in diet-induced obese mice. Meg3 knockdown induces cellular senescence of endothelial cells characterized by increased senescence-associated β-galactosidase activity, increased levels of endogenous superoxide, impaired mitochondrial structure and function, and impaired autophagy. Moreover, Meg3 knockdown causes cellular senescence of hepatic endothelium in diet-induced obese mice. Furthermore, Meg3 expression is elevated in human nonalcoholic fatty livers and nonalcoholic steatohepatitis livers, which positively correlates with the expression of CDKN2A encoding p16, an important hallmark of cellular senescence. Meg3 knockdown potentiates obesity-induced insulin resistance and impairs glucose homeostasis. Insulin signaling is reduced by Meg3 knockdown in the liver and, to a lesser extent, in the skeletal muscle, but not in the visceral fat of obese mice. We found that the attenuation of cellular senescence of hepatic endothelium by ablating p53 expression in vascular endothelium can restore impaired glucose homeostasis and insulin signaling in obesity. In conclusion, our data demonstrate that cellular senescence of hepatic endothelium promotes obesity-induced insulin resistance, which is tightly regulated by the expression of Meg3. Our results suggest that manipulation of Meg3 expression may represent a novel approach to managing obesity-associated hepatic endothelial senescence and insulin resistance.