cssi/SciSciGPT-SciSciNet huggingface dataset:
Developing and Implementing an Onboarding Program for an Academic Library: Strategies and Methods

Rapid growth in enrollment and the planned opening of a new, free-standing library building resulted in a large influx of new employees at the Jerry Falwell Library in summer 2013. As a result, the library administration wished to implement an onboarding program to ease the transition for both existing employees, who would have a large group of people to get to know, and new employees, who would need to learn the organization and their duties quickly. With a three-person steering committee reporting directly to the dean of the library, the New Employee WIFI Connector Program was born. This article chronicles its development and implementation.
Abstract 2881: Deubiquitinase Usp9x controls tumorigenicity through regulation of the Ets-1 transcription factor in melanoma

Transcription factors are frequently deregulated in cancer cells and may be good therapeutic targets, but few successful targeting strategies have been reported. Deubiquitinases (DUBs) are specialized enzymes that regulate the ubiquitin (Ub) content on many proteins and DUB expression and activity are elevated in a number of cancers where they can act to alter tumor suppressor and/or oncoprotein levels. We previously described Usp9x activity and expression in melanoma; here we sought to investigate its role in primary melanoma and metastatic disease. Usp9x was upregulated in tumor cells compared to normal melanocytes and Usp9x expression and activity were found to be essential for 3D growth and melanoma tumor expansion in vivo. We defined the Usp9x ubiquitinated protein landscape and demonstrate that Usp9x regulates Ets-1, a cancer-promoting transcription factor. Usp9x binds, deubiquitinates and thereby stabilizes Ets-1 protein, and primary tissue and tumor analysis demonstrated elevated and coincident Usp9x/Ets-1 protein expression in melanoma compared to normal skin or benign nevi. Usp9x knockdown or Usp9x inhibition with small molecule G9 reduced Ets-1 protein levels and blocked tumor growth in vitro and in vivo. Conversely, Usp9x overexpression in melanoma cells increased Ets-1 protein levels and enhanced 3D tumor growth in vitro and in vivo, which were all reversible by treatment with G9. We conclude that Usp9x is essential for Ets-1 protein stability and may be therapeutically exploited with small molecule Usp9x inhibitors to reduce Ets-1-dependent gene expression and tumorigenicity. Citation Format: Harish Potu, Luke F. Peterson Peterson, Malathi Kandarpa Kandarpa, Anupama Pal Pal, Hanshi Sun Sun, Paul W. Harms Harms, Peter C. Hollenhorst Hollenhorst, Ugur Eskiocak Eskiocak, Moshe Talpaz Talpaz, Nicholas J. Donato Donato. Deubiquitinase Usp9x controls tumorigenicity through regulation of the Ets-1 transcription factor in melanoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2881.
Noncanonical Microtubule Interaction of Yeast Kinesin-5 CIN8

Kinesin-5's were originally described as slow, plus-end-directed motors that are required for proper establishment and maintenance of the mitotic spindle. They share a bipolar homotetrameric structure with four heavy chains organized such that two motor domains are positioned at each end of a coiled-coil stalk, allowing the motor to cross-link and slide two antiparallel microtubules. Interestingly, recent studies have demonstrated bidirectional motility for yeast kinesin-5 motors, which represents a significant biophysical conundrum given our previous understanding of directed kinesin motility. We aim to understand the structural and biochemical features of yeast kinesin-5 motors that promote directional switching of motility. Saccharomyces cerevisiae Cin8 has been shown to switch directionality based on ionic strength, motor coupling and binding between antiparallel microtubules. Using ionic strength to promote switching of directionality, we have determined the microtubule binding behavior, steady-state kinetics, and cryo-EM structure of the Cin8 motor domain. Cosedimentation assays revealed that Cin8 binds super-stoichiometrically along the microtubule lattice with 3±1 motor domains binding per tubulin dimer. Competition assays with human kinesin-5 (Eg5) indicate that Cin8 binds at the canonical kinesin binding site as well as at a yet unidentified non-canonical site. Interestingly, Cin8 has microtubule-stimulated ATPase activity on both the canonical and non-canonical sites. We have probed the structural explanation for these biochemical observations by obtaining a 7A cryo-EM reconstruction of the microtubule-Cin8 complex in the ADP+AlFx state. Deletion of the large insert in Cin8's loop L8 retains similar steady-state ATPase activity yet abolishes super-stoichiometric microtubule binding, providing a powerful tool to dissect its ATPase mechanism. Cin8's microtubule interaction offers a mechanism for bidirectional movement, such that the motor utilizes a non-canonical microtubule site for directional switching.
Classification of generators participating in the bulk-power market

Economic studies in power systems have gained more importance post deregulation. The number of generators participating in the power market have significantly increased over the past years. Smart grids are now enabling distributed generation resources to also participate in the power market. Many economic studies conducted on power system networks utilize legacy quadratic cost curves which are based on very old coal-fired plants. This paper proposes a method to obtain generator cost curves that reflect realistic prices of a bulk power market. Cost curves are obtained from real market data for different generator types (e.g., base, peak) using k-Means clustering. The cost curves are used on the IEEE 24-bus test system to show that realistic locational marginal prices are obtained that emulate the real market data.
Phase II trial of neoadjuvant (neo) palbociclib (Palbo) plus anastrozole (ana) in endocrine resistant clinical stage 2/3 estrogen receptor positive and HER2 negative (ER+ HER2-) breast cancer (BC).

TPS592Background: Persistent cell proliferation (Ki67 > 10%) on tumor biopsies as early as 2-4 weeks (wks) on neo endocrine therapy (ET) identifies resistant tumors in ~20% patients (pts) with early stage ER+ HER2- BC who are at high risk of relapse. Palbo plus ET significantly improves progression free survival in pts with ET naive or resistant advanced ER+ HER2- BC, and is being evaluated in the adjuvant setting. However, biomarkers predictive of palbo sensitivity are unknown. Ki67 analysis of serial tumor biopsies in the neo palbo and ana (NeoPalAna) trial demonstrated that 2 wks of palbo plus ana potently inhibited Ki67 and induced complete cell cycle arrest (CCCA, Ki67≤2.7%) in tumors with high Ki67 post 4 wks ana run-in. This study is therefore aimed to prospectively investigate the biological activity of palbo plus ana in ET resistant ER+ HER2- BC. Methods: The primary objective is to assess the rate of CCCA (central Ki67 ≤2.7%) after 2 wks of neo palbo and ana. Secondary objectives include analysi...
Prognostic score to predict time to castration-resistance in underserved patients with metastatic prostate cancer.

e16518Background: This study aimed to identify predictors of time to castration-resistance prostate cancer (tCRPC) from initial diagnosis of metastatic prostate cancer (mPC) and develop a prognostic score in the underserved population of an inner-city tertiary care hospital. Methods: We retrospectively reviewed charts of 278 men diagnosed with mPC between 2001 and 2015, of which 155 patients were analyzed. Socio-demographic, clinical and pathologic factors were ascertained at the time of diagnosis. Kaplan-Meier and cox regression analyses were done to explore correlates tCRPC. Crude (HR) and adjusted (aHR) hazard ratios with 95% confidence intervals (CI) were obtained. Results: Over a median follow-up of 46 months (95% CI 23-69), 73.5% of men developed castration-resistance. Median tCRPC was 16 months (95% CI 12.5-19.5). All patients received medical or surgical castration at the time of diagnosis. Significant correlates of short tCRPC included: prostate specific antigen >20 ng/mL (HR 2.56, 95% CI 1.25-5....
Esophageal Injury and Atrioesophageal Fistula Caused by Ablation for Atrial Fibrillation

Esophageal perforation is a dreaded complication of atrial fibrillation ablation that occurs in 0.1% to 0.25% of atrial fibrillation ablation procedures. Delayed diagnosis is associated with the development of atrial-esophageal fistula (AEF) and increased mortality. The relationship between the esophagus and the left atrial posterior wall is variable, and the esophagus is most susceptible to injury where it is closest to areas of endocardial ablation. Esophageal ulcer seems to precede AEF development, and postablation endoscopy documenting esophageal ulcer may identify patients at higher risk for AEF. AEF has been reported with all modalities of atrial fibrillation ablation despite esophageal temperature monitoring. Despite the name AEF, fistulas functionally act 1 way, esophageal to atrial, which accounts for the observed symptoms and imaging findings. Because of the rarity of AEF, evaluation and validation of strategies to reduce AEF remain challenging. A high index of suspicion is recommended in patients who develop constitutional symptoms or sudden onset chest pain that start days or weeks after atrial fibrillation ablation. Early detection by computed tomography scan with oral and intravenous contrast is safe and feasible, whereas performance of esophageal endoscopy in the presence of AEF may result in significant neurological injury resulting from air embolism. Outcomes for esophageal stenting are poor in AEF. Aggressive intervention with skilled cardiac and thoracic surgeons may improve chances of stroke-free survival for all types of esophageal perforation.
A Platform for Developing Robotic Navigation Strategies in a Deformable, Dynamic Environment

While in vivo robotic locomotion has demonstrated its potential through a number of means, sensing and closed-loop control for such devices have not been at the forefront of research. By enabling real-time navigation, capsule endoscopy could transform from passive capsule endoscopes (CEs) and remote-controlled robotic CE devices into semi- or fully autonomous, surgical tools. In this work, a novel robotic endoscope platform (REP) is designed and tested. This platform will be used to evaluate control, localization, and mapping techniques necessary to endow a robotic CE with autonomous features. REP performance was benchmarked against design requirements that included sensing, speed, and maneuverability. It was found that the REP could accelerate to a maximum speed of 80 mm/s in less than 0.2 s and could achieve a zero-point turning radius. Most significantly, a low-cost image segmentation algorithm was developed to enable real-time lumen navigation/center tracking. Visual navigation time trials were compared to manual user trials through a 90-degree turn in a deformable simulator, exhibiting mean run times 34% faster than manual users. This demonstrates the REP's maneuverability and sensing capabilities allowing for future implementation of a range of advanced sensing and control techniques ahead of robotic CE adoption.
Small Hankel Operators

In this chapter, we study small Hankel operators on the Fock space F α 2. Problems considered in the chapter include boundedness, compactness, and membership in the Schatten class S p . We will also determine when a small Hankel operator has finite rank.
The Turán — Kubilius Inequality and Its Dual

Let f(n) be a complex-valued additive arithmetic function, $$ f(n) = \sum\limits_{p^k ||n} {f(p^k )}$$ .
Are seven standard photographic fields necessary for classification of diabetic retinopathy

Stereoscopic fundus photography of seven fields has become standard procedure for detecting diabetic retinopathy. However, the question has arisen as to whether adequate detection of retinopathy can be achieved with fewer fields. This question was investigated in a population-based study of 2694 diabetic persons. Retinopathy levels derived from the detailed grading of all seven fields were compared with those derived from combinations of two, three or four fields, the data for these being selected from the grading of the full seven fields. For eight retinopathy levels, the rate of agreement with seven fields ranges from 80% for two fields to 91% for four fields. For four retinopathy levels, agreement increases to 85 to 95%. The rate of agreement also varies with the specific retinopathy level, with level 65 being especially sensitive to the number of fields. The sensitivity of two to four fields compared to seven fields for detecting any retinopathy varies from 87 to 95%. For detecting proliferative retinopathy, sensitivity varies from 74 to 90%, and for Diabetic Retinopathy Study high-risk characteristics, it varies from 81 to 91%. Analysis of two groups of 50 eyes in which the combinations of fields were graded independently shows a small but nonsignificant effect of field overlap. These results indicate that in some situations, fewer fields may be adequate.
Cultural Epistemologies of Motherhood

For two consecutive academic sessions, 2001 and 2002, Harpur College of Binghamton University funded two interdisciplinary workshops to examine the social practices that play a significant role in understanding motherhood. The first workshop focused on recent works in the field of African and African Diaspora women’s studies. Though motherhood was the entry point for theoretical investigation, the workshops also examined other family-related relationships and the importance of these in the formulation of theories of identity and personhood. The following set of questions initiated participants’ discussions: What are the prevailing conceptions of motherhood in Africa, the Caribbean and the United States? What does the articulated concept of ‘mother’ tell us about family history, family identity and family cohesiveness? Discussions highlighted cultural attitudes about motherhood in several countries—Kenya, Nigeria, Senegal, Jamaica, Haiti, the United States and Poland—as well as the similarities and differences in mothering styles among Africans, African-Americans, and Caribbeans.
LED communicator in various underwater environments

Demand for underwater communication in the 21st century has been growing. Underwater communication technologies are needed in many different environments; ranging from the underwater environments of the seas to small ponds. Underwater communication technologies used in these environments are used in a multitude of ways, such as, monitoring evolutionary changes, surveillance, underwater sensor networks, and military communication between ships and underwater-unmanned vehicles. Traditionally underwater communication has been accomplished using acoustic techniques that have data rates that can range from the kb/s and into the Mb/s. Interest in the use of optical communications has increased with the growing need for higher data rates, as well as, a secure way of transmitting it. Optical communications are capable of providing data speeds in the Gb/s due to a larger available bandwidth. Optical communications are also inherently more secure due to the directional nature of the transmission. That said, there are a number of challenges to optical communications, which include scattering, absorption, extinction, and optical turbulence in underwater environments. This paper presents the performance of an inexpensive LED communication system operating in various emulated underwater environments. Specifically, we propagated ASCII data through various underwater environments, and analyzed system performance under the effects of salinity level, temperature turbulence effects, mechanically generated turbulence, as well as the misalignment between the transmitter and receiver. Relevant performance metrics studied include bit error rates, power received, and channel data rates.
School Counselor Transgender Intersex Advocacy Competence Scale (SCTIACS): Construction and Validation:

The purpose of this study was to develop the School Counselor Transgender Intersex Advocacy Competence Scale (SCTIACS). The SCTIACS is a training tool to use in teaching school counselors and other...
Healthcare facility-based strategies to improve tuberculosis testing and linkage to care in non-U.S.-born population in the United States: A systematic review

Author(s): Miller, Amanda P; Malekinejad, Mohsen; Horvath, Hacsi; Blodgett, Janet C; Kahn, James G; Marks, Suzanne M | Abstract: ContextAn estimated 21% of non-U.S.-born persons in the United States have a reactive tuberculin skin test (TST) and are at risk of progressing to TB disease. The effectiveness of strategies by healthcare facilities to improve targeted TB infection testing and linkage to care among this population is unclear.Evidence acquisitionFollowing Cochrane guidelines, we searched several sources to identify studies that assessed strategies directed at healthcare providers and/or non-U.S.-born patients in U.S. healthcare facilities.Evidence synthesisSeven studies were eligible. In a randomized controlled trial (RCT), patients with reactive TST who received reminders for follow-up appointments were more likely to attend appointments (risk ratio, RR = 1.05, 95% confidence interval 1.00-1.10), but rates of return in a quasi-RCT study using patient reminders did not significantly differ between study arms (P = 0.520). Patient-provider language concordance in a retrospective cohort study did not increase provider referrals for testing (P = 0.121) or patient testing uptake (P = 0.159). Of three studies evaluating pre and post multifaceted interventions, two increased TB infection testing (from 0% to 77%, p l .001 and RR 2.28, 1.08-4.80) and one increased provider referrals for TST (RR 24.6, 3.5-174). In another pre-post study, electronic reminders to providers increased reading of TSTs (RR 2.84, 1.53-5.25), but only to 25%. All seven studies were at high risk of bias.ConclusionsMultifaceted strategies targeting providers may improve targeted TB infection testing in non-U.S.-born populations visiting U.S. healthcare facilities; uncertainties exist due to low-quality evidence. Additional high-quality studies on this topic are needed.
Revisiting Amodal Completion and Knowledge

In a recent paper, Helton and Nanay (Analysis, 79(3), 415–423, 2019) present a new argument against two modal accounts of knowledge—safety and sensitivity. Their argument is based on the phenomenon of amodal completion (i.e. the phenomenon of representing occluded parts of a perceived object). According to them, amodal completion experience can ground knowledge; but in some instances, such knowledge is neither sensitive nor safe. Thus, they conclude that neither sensitivity nor safety is a necessary condition for knowledge. This paper pushes back. In particular, I defend the following three theses. First, Helton and Nanay’s argument for the claim that amodal completion itself can ground knowledge is unsound. Second, their objection against sensitivity is best construed as merely another instantiation of the old objection against sensitivity regarding inductive knowledge. Thus, sensitivity theorists have nothing to worry about over and above the old objection. Third, safety theorists can plausibly defend their account, insofar as they acknowledge that one’s ‘awareness’ of (close) error-possibilities can affect the epistemic status of one’s belief. My conclusion is that reflections on the phenomenon of amodal completion fail to generate any new objections against modal accounts of knowledge.
Racial Identity Among White Americans: Structure, Antecedents, and Consequences

In this chapter, I examine the structure, determinants, and selected attitudinal consequences of racial identity among white Americans. In 2014, the General Social Survey included five items tapping five aspects or dimensions of racial identity: prominence, salience, private self-regard, public self-regard, and verification. These items reflect our understanding of identity as a multidimensional phenomenon and are useful to a research agenda casting racial identity in such terms. However, given the inherent limitations of single-item indicators of various aspects of identity, and in light of the underdevelopment of research on white racial identity, exploration of multi-item measurement strategies for racial identity is also warranted. I use factor and reliability analyses to examine the structure of white racial identity, finding sufficient inter-item consistency to support creation of a five-item “identity intensity” index (alpha = 0.84). I then use regression analysis to expand our understanding of white racial identity as both “social product and social force” (Rosenberg 1981), by modeling how it is shaped by sociodemographic factors, while also carrying implications for whites’ racial policy attitudes.
Cyclescapes of the Unequal City: Bicycle Infrastructure and Uneven Development: By John StehlinMinneapolis: University of Minnesota Press, 2019.

In his 1973 book Energy and Equity, the polymath Ivan Illich opens with a quote from the Chilean Socialist Jose Antonio Viera-Gallo. Translated from Spanish, the epigraph reads, “Socialism can only...
Using Novel Configuration Techniques for Accelerated FPGA Aging

In this work we demonstrate a novel method of accelerating FPGA aging by configuring the FPGA to implement thousands of short circuits, resulting in high on-chip currents and temperatures. Three ring oscillators are placed across the chip and are used to characterize the operating frequency of the FPGA fabric. Over the course of several weeks of running the short circuits, with daily characterization of the FPGA performance, we measured a decrease in FPGA frequency greater than 5%. After aging, the FPGA part was repeatedly characterized during a two week idle period. Results indicated that the slowdown did not change, and the aging appeared to be permanent. In addition, we demonstrated that this aging could be induced in a non-uniform manner. In our experiments, the short circuits were all placed in the lower two-thirds of the chip, and one of the characterization ring oscillators was placed at the top of the chip, outside of the region with the short circuits. The fabric at this location exhibited a 1.36% slowdown, only one-quarter the slowdown measured in the targeted region.
Antidepressants and Their Impact on Sleep

Given the strong bidirectional relationship between sleep disruption and psychiatric conditions, particularly between depression and insomnia, it is important to understand the beneficial and potentially harmful effects of antidepressants on sleep. Antidepressants remain commonly used off-label for the treatment of chronic insomnia. SSRI, SNRI, and TCA drugs reduce REM sleep and increase REM latency. TCA drugs can be sedating or stimulating. Low-dose doxepin improves sleep continuity and is FDA approved for the treatment of chronic insomnia. Trazodone, the most commonly used antidepressant, reduces the number of awakenings. Preclinical studies have shown potential antidepressant effects of orexin antagonists, which are used to treat insomnia. Data on the usage of most antidepressants for insomnia remain limited. Low-dose doxepin is the only FDA-approved antidepressant for insomnia. Orexin antagonists may represent a future approach for treatment of both depression and insomnia.
The Stapes in Otosclerosis: Osteoarthritis of an Ear Ossicle

Otosclerosis is a pagetoid proliferation of bone remodeling, vascular proliferation, bone resorption and new bone formation in the tympanic region of the temporal bone. The resulting anklyosis of the stapes footplate as it articulates with the oval window is the most common cause of conductive hearing loss in young to middle aged, predominantly Caucasian individuals. The characteristic histologic features have been well documented by autopsy studies of the temporal bone. Although stapedectomy is the surgical treatment for otosclerosis, the stapes specimen may be submitted for gross examination only or not examined at all. A retrospective study of 73 stapedectomy specimens (2008-2019) not including the stapes footplate. Clinical features from the electronic medical record as well as standard histologic sections from surgical specimens were reviewed. Neither the stapedal head nor crura showed histologic features of otosclerosis. There was mild osteoarthritis affecting the head, possibly as a consequence of persistent ossicular vibration superimposed on the ankylosed rigidity. The most common changes were surface fissuring (65%), cartilaginous erosion (49%) and irregularity of the osteochondral interface (51%). An occasional osteophyte (8%) was observed. The ear ossicles, embryologically analogous to long bones of the extremities, develop via endochondral ossification and exhibit articular surfaces of hyaline cartilage. The present observations suggest that a consequence of otosclerotic ankylosis is osteoarthritis of the stapedal head. In this study, the histological features could not be correlated with the severity of hearing loss or duration of clinical disease.
Dielectrowetting Control of Capillary Force (Cheerios Effect) between Floating Objects and Wall for Dielectric Fluid.

A capillary interaction between floating objects and adjacent walls, which is known as “Cheerios effect”, is a common phenomenon that generates capillary attraction or repulsion forces between them depending on their wettabilities, densities, geometries, and so on. This paper deals with controlling the capillary forces, specifically, acting on objects floating on a dielectric (non-conductive) fluid. A key control input parameter is the wettability (contact angle) of the sidewall adjacent to the floating object. By introducing dielectrowetting to the sidewall and actively changing the contact angle on the sidewall, the capillary force is controlled and easily reversed between attraction and repulsion. In this reversing process, the tilting angle of the sidewall is another critical parameter. A theoretical relation taking the titling angle into account is compared and in good agreement with experimental results obtained from the trajectory of the floating object. Finally, a continuous motion of the floating object is demonstrated using this control where an array of dielectrowetting electrode pads is sequentially activated.
South Atlantic deep eastern boundary current driven by Agulhas rings: An idealized study

Abstract The deep eastern boundary current (DEBC) in the southeast Atlantic Ocean plays an important role in the global meridional overturning circulation, by carrying a comparable fraction of the North Atlantic Deep Water transport toward the Southern Ocean to that of the deep western boundary current. At the same time, the southeast Atlantic Ocean is constantly influenced by energetic Agulhas rings that are shedded by the Agulhas current. It has been pointed out that the eddy thickness transport by these Agulhas rings is important in enabling the deep water mass that flows southeastward within the interior of the South Atlantic Ocean to cross isolines of large scale potential vorticity toward the eastern boundary where it feeds the DEBC. In this work, we focus on the dynamics of DEBC itself which carries this water mass into the Southern Ocean. We use idealized general circulation model configurations to study the relationship between the Agulhas rings, bathymetry and the southward DEBC in southeast Atlantic Ocean. We find that a DEBC comparable to that in observations and state estimate products is obtained only with combined forcing by Agulhas rings and a sloping bathymetry. The DEBC is then characterized by a mid-depth core at a 2.2 km, again similar to observations. We analyze the momentum and vorticity budgets of the DEBC and show that it is driven by vortex stretching that is sensitive to both eddy temperature transport and the bottom slope.
Dividend Tax Clienteles: Evidence from Tax Law Changes

We investigate institutional investors' preference for dividend-paying stocks following changes in the dividend tax penalty during the sample period from 1987 until 2004. Following prior literature we separate institutions into tax-advantaged and taxable cohorts and find that when the dividend tax penalty is positive, high-dividend firms constitute a significantly larger (smaller) percentage of tax-advantaged (taxable) institutions' portfolios. Multivariate regressions involving institutional ownership levels and changes confirm our initial findings. We estimate (for the median dividend-paying firm) when the dividend tax penalty decreases by 23.3%, we expect tax-advantaged (taxable) institutional ownership will decrease by 0.36% (increase by 0.25%) of a firm's shares outstanding. We find our results are robust for a subsample of firms that do not change their dividend policy. Overall, our paper provides strong support for the existence of institutional dividend tax clienteles.
Variation in opioid prescribing patterns after abdominal transplant surgery.

BACKGROUND Opioids are associated with negative transplant outcomes. We sought to identify patient and center effects on over-prescribing of opioids (> 200 OME (oral morphine equivalents)). STUDY DESIGN Clinical and opioid prescription data (2014-2017) were collected from three academic transplant centers for kidney (KT), liver (LT), and simultaneous liver-kidney transplant (SLK) patients. Multivariable models were used to identify predictors of opioid over-prescribing at discharge and the occurrence of refill prescriptions at 90 days. RESULTS Three-thousand seven-hundred and two patients underwent transplant in the cohort (KT: n = 2358, LT: n = 1221, SLK: n = 123). More than 80% of recipients were over-prescribed opioids at discharge (Median OME (mOME) = 300 (IQR 225-375). LT and SLK had the largest prescription size (LT mOME 338 (IQR 300-450); SLK mOME 338 (IQR 225-450) and refill rate (LT: 64%, SLK 59%) (all, P < .001). Multivariable analysis indicated that transplant center was a significant predictor of opioid over-prescription after KT and LT (all, P < .001); older age (in KT) and length of stay (LOS) (in LT) were protective factors (both, P < .05). Refill occurrence was associated with initial prescription size and was reduced by older age and initial LOS (all, P < .05). CONCLUSIONS The wide variation in opioid prescribing patterns has implications for transplant practice innovation, guideline development, and further study.
Maximal lineability of the class of Darboux not connectivity maps on $${\mathbb {R}}$$ R

We provide an elegant argument showing, in ZFC, that the class $${{\,\mathrm{PES}\,}}{\setminus }{{\,\mathrm{Conn}\,}}$$ of all functions from $${\mathbb {R}}$$ to $${\mathbb {R}}$$ that are perfectly everywhere surjective (so Darboux) but not connectivity is $$2^{\mathfrak {c}}$$ -lineable, that is, that there exists a linear subspace of $${\mathbb {R}}^{\mathbb {R}}$$ of dimension $$2^{\mathfrak {c}}$$ that is contained in $$({{\,\mathrm{PES}\,}}{\setminus }{{\,\mathrm{Conn}\,}})\cup \{0\}$$ . This solves a problem from a 2020 paper of Albkwre, Ciesielski, and Wojciechowski. The construction utilizes a transcendental basis of $${\mathbb {R}}$$ .
Alternative Endograft Aortoiliac Reconstruction for Iliac Branch Endoprostheses

Background Endovascular treatment of complex common iliac artery (CIA) and internal iliac artery (IIA) aneurysms using iliac branch endoprostheses (IBE) has proven safe and effective. Instructions for use (IFU) require deployment of current IBE technology with the corresponding manufacturer's modular bifurcated aortic endograft. Concomitant aortoiliac occlusive disease, inadequate renal artery-iliac bifurcation length, and unfavorable aortic anatomy preclude on-label IBE deployment. This study aimed to evaluate the technical feasibility and safety of Alternative Endograft Aortoiliac Reconstruction (AEGAR) for branched endovascular treatment of complex iliac artery aneurysms. Methods In 7 consecutive patients with CIA or IIA aneurysms, computed tomography angiography (CTA) and center-line reconstruction revealed aortoiliac anatomy incompatible with the current IBE IFU due to inadequate proximal CIA landing zone (n = 7), inadequate renal artery to iliac bifurcation length (n = 2), compromised aortic anatomy (n = 3), or short infrarenal neck Results The mean patient age was 69 years (range 52–82 years; 6 male). Four patients had bilateral CIA aneurysms and 3 patients had unilateral CIA aneurysms (mean diameter 4.3cm; range 2.2–7 cm). There were 13 IIA VBX stent grafts used for a total of 9 IIAs treated with IBE (bilateral IBE = 2 patients). The mean fluoroscopy time was 38.8 min (range 21.3–64.3 min) and the mean contrast volume was 168.5 mL (range 122–226 mL). Technical success was achieved in all patients and there were no perioperative complications. Mean hospital-stay was 2.2 days (range 1–3 days). Follow-up ranged from 82–957 days (mean = 487 days). At last follow-up, all patients were alive without cardiovascular morbidity; and CTA revealed stable or decreased aneurysm size, patent endografts, and no evidence of endoleak or migration. Conclusions The AEGAR technique can be used to safely and effectively overcome certain aortoiliac anatomic constraints that preclude use of current IBE technology. We encourage broader use of these alternative endografts in pertinent anatomic configurations.
Interaction of somatomedin and a peptide inhibitor in serum of hypophysectomized and starved, pituitary-intact rats.

Publisher Summary This chapter discusses the interaction of somatomedin and a peptide inhibitor in serum of hypophysectomized and starved, pituitary-intact rats. In the method described in the chapter, male rats of the Sprague–Dawley strain were used. Hypophysectomized rats were obtained from Hormone Assay Laboratories, Chicago, Illinois. Their age at the time of operation was 21–24 days, and the postoperative interval before experiments was 10 days or longer. Feeding was ad libitum except during the periods of starvation of normal rats. Individual segments of costal cartilage were incubated in 1 ml of medium at 37°C. The basal medium was a phosphate-buffered saline, pH 7.4, which contained glucose (2 mg/ml) and amino acids in the formulation of Eagle's basal medium for culture of HeLa cells plus 0.1 mM serine. Antibiotics—in early studies penicillin and streptomycin but more recently penicillin (100 units/ml) and gentamicin (50 μ/ml)—were included to inhibit bacterial growth. Sulfate incorporation was determined by incubation of the tissue in media to which 35 S-labeled sulfate was added. This study provided clues to an inhibitor associated with starvation. Sulfation-promoting activity of serum from starved rats fell progressively as starvation was prolonged.
Estrogen Effects on Neural Activation after Short-term Vs. Long-term Furosemide Treatment in Rats

Estrogen influences body Na+ balance, but the central pathways involved in these effects are currently unknown. Studies using immunohistochemical labeling of the fos protein to study central areas involved in body fluid balance report no effect of Na+ loss in male rats. However, standard methods of producing Na+ loss are of comparatively long duration, and it is possible central activation is not sustained. Accordingly, our objective was to assess the effect of estrogen on activation in response to short-term and long-term Na+ depletion using furosemide, a diuretic-natriuretic. Adult female rats were ovariectomized, allowed to recover for 7 days, and then given estradiol benzoate (EB; 10 μg/0.1 ml oil, sc) or oil vehicle (OIL; 0.1 ml, sc). Rats were injected with furosemide (2 X 5 mg/kg, sc) by one of two protocols. For the short term protocol, rats were perfused with paraformaldehyde 2 hrs after furosemide; for the long-term protocol, rats were perfused 18 hrs after furosemide. Brains were removed and cu...
Differential effect of cadmium on GSH-peroxidase activity in the leydig and the sertoli cells of rat testis: Suppression by selenium and the possible relationship to heme concentration

In the testes of rats treated with cadmium acetate (7 or 20 mumoles/kg, 24 hr, s.c.), the activity of glutathione (GSH)-peroxidase was increased. At the same time, the activity of glutathione disulfide (GSSG)-reductase and the cellular GSH concentration were decreased significantly. The basal activity of peroxidase in the Leydig and the Sertoli cell populations was comparable. However, the magnitude of increases in the activities markedly differed in the two cell populations, with that of the Sertoli cells increasing to nearly 450% of the control value in response to treatment with 20 mumoles/kg Cd2+. In the Leydig cells, the enzyme activity in response to the same treatment increased to only about 170% of the control value. Cd2+ treatment increased the concentration of heme in the microsomal and the smooth and rough endoplasmic reticulum fractions of the whole testis, as well as in the microsomal fractions of the Leydig and the Sertoli cells. As with the peroxidase activity, the two cell populations vastly differed in their susceptibilities to Cd2+ treatment, with the Sertoli cells being more severely affected by the metal. In the Sertoli cells the microsomal heme concentration was increased by approximately 11-fold, whereas only a 2-fold increase in the Leydig cells was noted. The increase in GSH-peroxidase activity was not due to the peroxidase activity of GSH-S-transferases, insofar as an increase in transferase activity was not observed in the Leydig and the Sertoli cells. Treatment of rats with sodium selenite (10 mumoles/kg, s.c.) 30 min before Cd2+ treatment (20 mumoles/kg) fully suppressed the above-described spectrum of effects of Cd2+ in the testis. Also, sodium selenite at a lower dose of 5 mumoles/kg prevented an increase in GSH-peroxidase activity. It is hypothesized that increased GSH-peroxidase activity in the Leydig and the Sertoli cells constitutes an adaptive response to increased cellular levels of heme and to the free radicals generated by the heme molecule. Selenium prevents the increase in GSH-peroxidase activity by circumventing the increase in cellular heme concentration. The protection is believed to be related, at least in part, to increased production of cellular GSH.
Minimum-Latency Beaconing Schedule in duty-cycled multihop wireless networks

Beaconing is a primitive communication task in which every node locally broadcasts a packet to all of its neighbors within a fixed distance. The problem Minimum Latency Beaconing Schedule (MLBS) seeks a shortest schedule for beaconing subject to the interference constraint. MLBS has been well studied when all the nodes are always awake. However, it is well-known that the networking nodes often switch between the active state and the sleep state to save energy. A node in duty-cycled scenarios may require transmitting multiple times to inform all of its neighbors due to their different active times. Thus, all of the known algorithms for MLBS are not suitable for duty-cycled multihop wireless networks. In this paper, we study MLBS in Duty-Cycled multihop wireless networks (MLBSDC). We first present two constant-approximation algorithms for MLBSDC under the protocol interference model with the approximation bounds independent of the length of a scheduling period. Then, we develop an efficient algorithm for MLBSDC under the physical interference model. To the best of our knowledge, this is the first paper that develops efficient algorithms for MLBSDC under either of these two interference models.
Sourcing preference scale: Measuring preferences of purchasing managers for single sourcing or multiple sourcing of products

Abstract This study examines single and multiple sourcing of products. A scale, the sourcing preference (SP) scale, is developed to measure purchasing manager attitudes towards either single or multiple sourcing. The scale is then used to determine differences in selected demographic and organizational characteristics between purchasing managers who have a preference for single sourcing and those who have a preference for multiple sourcing.
Modeling Lifelong Learning: Collaborative Teaching across Disciplinary Lines.

Most courses in colleges and universities are taught by only one instructor. This is often necessitated by the financial exigencies of educational institutions, but is also due to an academic tradition in which the ideal is a single expert teaching in a single discipline. The rapidly changing realities of both the higher education and job markets, however, have called the traditional ideal into question. Interdisciplinary collaborative teaching is one way to adapt to the needs of twenty-first-century students, by modeling lifelong learning for students and inviting instructors to be more deliberately reflective about disciplinary assumptions, learning styles, and pedagogies.
A sensor for estimating the liquid mass fraction of the refrigerant exiting an evaporator

A traditional method of controlling evaporator superheat in a vapor compression air conditioning system is the thermostatic expansion valve (TXV). Such systems are often used in automotive applications. The TXV depends on superheat to adjust the valve opening. Unfortunately, any amount of superheat causes that evaporator to operate at reduced capacity due to dramatically lower heat transfer coefficients in the superheated region. In addition, oil circulation back to the compressor is impeded. The cold lubricant almost devoid of dissolved refrigerant is quite viscous and clings to the evaporator walls. A system that could control an air conditioner to operate with no superheat would either decrease the size of its existing evaporator while maintaining the same capacity, or potentially increase its capacity with its original evaporator. Also, oil circulation back to the compressor would be improved. To operate at this two-phase evaporator exit condition a feedback sensor would have to quantify the quality of liquid mass fraction (when the exit stream is a mixture of droplets and superheated vapor) of the refrigerant exiting the evaporator.
Protection of Micrococcal Nuclease against Thermal Inactivation

Abstract Micrococcal nuclease in solution is protected from thermal inactivation for at least 5 hours by the simultaneous presence of 0.01 mCa++, 0.05% bovine serum albumin, and one of the products of the enzymatic reaction. The following products of digestion of DNA render protection: each of the four 3'-mononucleotides, those of deoxyadenosine and deoxythymidine being the most effective; and each of the tested dinucleotides, among which that of deoxyadenosine is the best and that of deoxyguanosine, the worst. When any of the three components (albumin, Ca++, or products) is omitted the other two are ineffective, suggesting that the mechanism of protection involves an interaction between all three and the enzyme. Each of the four 3',5'-deoxynucleoside diphosphates inhibits the action of micrococcal nuclease to some extent. However, the 3',5'-deoxynucleoside diphosphates of thymine and adenine are much more effective inhibitors than those of guanine and cytosine. The same type of base preference as that previously established for the hydrolytic action of the enzyme is now described for the protective effect of the reaction products and for the inhibiting effect of 3',5'-deoxynucleoside diphosphates. All three phenomena, therefore, appear to occur at, or in the vicinity of, the active center.
Soil nutrient removal by four potential bioenergy crops: Zea mays, Panicum virgatum, Miscanthus×giganteus, and prairie

A B S T R A C T Replacing annual row crops with perennial grasses for bioenergy represents a landscape-level change in species composition, with the potential to impact annual soil nutrient removal on a regional scale. In this study we measured the concentration of ten essential nutrients in harvested material from three potential perennial bioenergy crops: Panicum virgatum L., Miscanthusgiganteus, and a reestablished prairie to determine annual soil nutrient removals. We compared perennial bioenergy crops to nutrient removals by annual cropping systems of Zea mays L. (maize) and Glycine max L. (soybean) in Illinois. Crops were grown under management practices typical for the Midwest, US. In addition, we examined geographic variation in nutrient removal of M. � giganteus at four US locations. Total removal of N, P, K, Ca, Mg, S, Fe, Mn, Na, and Zn was significantly greater in maize than in any of the perennials. Removal of N, P, and K in M. � giganteus was 3.7, 1.8, and 1.8% of the removal in maize, and 49.0, 17.4, and 31.9% of the removal in soybean respectively. At sites in Illinois, Kentucky, Nebraska, and New Jersey we found differences in N and K removal by M. � giganteus that corresponded with differences in biomass. There was no effect of fertilization on M. � giganteus biomass, but removal of N, S, and Mg increased and P removal decreased with increasing rates of urea fertilization. Cultivation of M. � giganteus and switchgrass on land formerly used for row crops may reduce the need for nutrient additions and potential losses of nutrients to groundwater and the atmosphere.
Speech synthesis using damped sinusoids.

A speech synthesizer was developed that operates by summing exponentially damped sinusoids at frequencies and amplitudes corresponding to peaks derived from the spectrum envelope of the speech sign...
The Role Played by Orbital Energetics in Solvent Mediated Electronic Coupling

Electron-transfer rates are measured for three supramolecular species, which contain an electron donor, electron acceptor, and rigid connecting bridge. Two of the species are linear and the third species is C-shaped. The latter topology produces a 10 A wide, solvent accessible gap between the donor and the acceptor units. This molecular design allows the dependence of the electron-transfer rate on the solvent's electronic character to be evaluated. The results display a strong correlation between the energy of the solvent's lowest unoccupied molecular orbital and the magnitude of solvent mediated electronic coupling in systems with electronically excited donors. The variation of the electronic coupling with solvent modulates transfer rate constants by more than an order of magnitude.
INTERFACIAL POLYMERIZATION OF THIN POLYMER FILMS ONTO THE SURFACE OF A MICROPOROUS HOLLOW-FIBER MEMBRANE

Abstract Two methods for synthesizing thin films of chemically selective polymers onto the surface of microporous hollow-fiber membranes are described. The first involves interfacial redox polymerization and yields thin films of electronically conductive polymers (e.g., polypyrrole,poly (N-methylpyrrole), poly-aniline) on the outside surface of the hollow-fiber membrane. The second method entails interfacial photopolymerization of styrenic monomers on the surface of the hollow-fiber membrane. Such coated hollow-fiber membranes are potentially useful in membrane-based separation technologies such as pervaporation and industrial gas separations. We also investigated the transport properties of the coated hollow-fiber membranes described here using a simple pervaporation-type experiment.
Examining the relationships among user involvement, profile quality, and information filtering performance

Three major types of user profile acquisition modes employed in diverse filtering systems were identified: a rule-based user driven mode, an explicit-learning mode, and an explicit-learning mode. The main goal of this study was to clarify the influence of different levels of user involvement in these three profile acquisition modes and their impact on profile accuracy and filtering performance. Three versions of a filtering system utilizing the different acquisition modes and a baseline version without a profile acquisition mode were developed. Thirty-five students were recruited from the Indiana University and were randomly assigned to the four different types of systems (i.e., four experimental groups were formed). Results obtained from the four groups showed that different profile acquisition modes had varying impact on profile accuracy and filtering performance.