cssi/SciSciGPT-SciSciNet huggingface dataset:
Against deliberative indispensability as an independent guide to what there is

David Enoch has recently proposed that the deliberative indispensability of irreducibly normative facts suffices to support their inclusion in our ontology, even if they are not necessary for the explanation of any observable phenomena. He challenges dissenters to point to a relevant asymmetry between explanation and deliberation that shows why explanatory indispensability, but not deliberative indispensability, is a legitimate guide to ontology. In this paper, I aim to do just that. Given that an entity figures in the actual explanation of some phenomenon, it is not an open question whether that entity exists. Thus, if you can manage to find actual explanations, you can find answers to ontological questions. In contrast, even if some entity is indispensable to deliberation, it still might not exist. For example, even if some form of libertarian free will is deliberatively indispensable, we still might not have libertarian free will. So even if you manage to discover the indispensable commitments of deliberation, there is still more work to do to get to the bottom of things. That additional work is explanatory work, and so deliberative indispensability is not an independent guide to what there is.
Fractional Replications of 2p Factorial Experiments With the Factors Applied Sequentially

In [1] a design, referred to as a Factor Sequencing Design (FSD), and analysis are presented for 2p factorial experiments where the factors are applied sequentially and where order of application may be of importance. The number of units required for an FSD is p!, which may be prohibitively large for p ≥ 4. This paper presents a method for fractionating the FSD and gives specific designs with their associated analyses for p equal 3, 4, 5, and 6.
Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER)-The best choice for geologists

The development of the space remote sensing technology provides a wealth of usable remote sensing data for geologist. In these remote sensing data ASTER has broad spectral bandwidths from VNIR to TIR and can meet the requirements for classifications of most minerals and rocks. In addition to the conventional data processing methods, the hyperspectral techniques for rock and mineral information recognition and extraction may also be used to process the multiband data of ASTER and yield more accurate mineral and rock classification results. The GIS evaluation model may be used to process altered rock information interpreted by ASTER, which may produce accurate remote sensing anomalies and guide mineral exploration.
On Imagination of the Control of Moral Risk in the Construction of Deposit Insurance in China

The moral risk in deposit insurance exists objectively.The legal system of deposit insurance that China is studying and constructing should be built by using for reference of the experience of advanced foreign countries so as to control the possible moral risk and protect the stability and development of financial system.
Modeling the oscillative behavior and carbon monoxide removal by current pulsing technique in H2/CO mixtures for Pt catalyst layer

Abstract The main objectives of this study are to investigate the carbon monoxide (CO) poisoning and a mitigation method of high-level CO in a platinum (Pt) catalyst layer using hydrogen (H2)/CO mixture as the inlet fuel. Two separate levels of poisoning, 1000 and 10,000 ppm CO at the anode fuel, are considered and investigated in detail. For this purpose, a one-dimensional transient model is developed including the diffusion of hydrogen and carbon monoxide, the conservation of adsorbed species, and ionic and electronic charges. As a result of CO poisoning, oscillations in overpotential and coverage of adsorbed species are observed for 1000 ppm CO level, while the similar situation is not detected for 10,000 ppm CO. Hence, the behavior of oscillations throughout the catalyst layer thickness, and the reasons are explored for the lower concentration case. For 10,000 ppm CO, a mitigation technique, in which current density is pulsed from 0.1 to 2.5 A/cm2 for a period of time, is performed in order to remove the adsorbed CO from the Pt sites. It is concluded that up to 92% of CO coverage within the catalyst layer can be removed, and 70% of the catalyst layer length is determined to be completely CO-free following the application of current pulsing.
Investigative Resources and Crime Clearances: A Group-Based Trajectory Approach

Past studies of crime clearance rates have largely ignored the role of investigators in the process. This omission is important because criminal investigation is essential to clearing crimes, particularly those in which offenders are not readily identifiable. Using data from 570 law enforcement agencies spanning a 13-year period from 2000 to 2012, this study developed group-based trajectories of violent and property crime clearance rates (an approach not taken in previous clearance rate research), then modeled group membership with two measures of investigative spending and one of the proportion of investigators in sampled agencies (“investigative resources”), while controlling for factors such as workload and crime type. Results from a series of multinomial regression models suggest investigative resources play only a marginal role in crime clearance trajectories. This finding is consistent with early detective research, including the classic RAND criminal investigative process study.
Mechanisms of Cardiac Valve Failure and the Development of Tissue Engineered Heart Valves

Calcification of the aortic valve results in valvular dysfunction and is an important cause of morbidity and mortality. Our understanding of the process of aortic valve calcification has changed from a passive wear and tear process to that of an actively regulated process with known molecular mediators. Prior to calcification of the valve, activated valvular interstitial cells coordinate maladaptive extracellular matrix remodeling of the leaflets. Bioprosthetic heart valves used to surgically replace stenotic aortic valves have excellent hemodynamic profiles and are anti-thrombogenic. However, they fail due to similar mechanisms as native aortic valves and thus durability is a limiting factor. Mechanical prostheses necessitate anticoagulation. Ideal heart valve substitutes would be non-thrombogenic, maintain excellent hemodynamics, but would be durable and may hold the promise of growth. The basics of tissue engineering include fabricating a scaffold onto which autologous cells may be incorporated. The cells then transform the scaffold to autologous tissue with the ability to function in its desired location in the body. Popular scaffolds are decellularized allografts or xenogeneic aortic valves as they have the complex structure of the aortic valve still intact. Recellularization with valvular endothelial cells has been successful but avenues for recellularizing valvular interstitial cells are still being pursued. Alternative methods for generating scaffolds include three dimensional bioprinting and electrospinning.
Deinstitutionalization of severely handicapped children: Locus of control and incentive orientations as important indicators

Severely physically handicapped children in deinstitutionalized and institutionalized programs were assessed on measures of locus of control and incentive orientation. Children in institutionalized...
Long-term pediatrician outcomes of a parent led curriculum in developmental disabilities.

Abstract Previous research has demonstrated high satisfaction and perceived relevance of Project DOCC (Delivery of Chronic Care), a parent led curriculum in developmental disabilities, across a sample of medical residents. Aims The influence of such a training program on the clinical practices and professional activities of these residents once they are established in their careers as physicians, however, has not been studied; this was the aim of the present study. Methods An anonymous follow-up survey was designed and disseminated to physicians who participated in Project DOCC during their one-month developmental disabilities rotation as part of their pediatrics or medicine/pediatric residency between 2002 and 2010. Fifty-eight physicians completed the survey. Results The findings suggest that participation in a parent led curriculum during medical residency had a lasting impact on physicians' relationships with families. Specifically, a majority of the physicians espoused a family-centered approach to care, a sensitivity to the interactional effect that caring for a Child with Special Health Care Needs (CSHCN) has on family members, the need for physicians to have a prominent role in community resource coordination, and the importance of an integrated approach to health care provision. Conclusions Use of a parent led curriculum as a means to increase the provision of family-centered care by physicians is supported.
Statin Use Improves Overall Survival and Time to Treatment Failure in Patients with Primary CNS Lymphoma.

Abstract 2496 Poster Board II-473 Background: HMG-CoA reductase inhibitors (statins) have been used to treat hypercholesterolemia and hyperlipidemia for over 20 years. Statins competitively inhibit HMG-CoA reductase thereby blocking the synthesis of mevalonate. They directly inhibit synthesis of steroid hormones and cholesterol but also indirectly inhibit prenylation and ubiqitination. As all currently marketed statins are lipophillic, with the exception of Pravachol (pravastatin), several therapeutic trials have attempted to exploit these indirect actions to treat both neoplastic (glioblastoma, anaplastic astrocytoma) and degenerative (Alzheimer9s, Parkinson9s) neurologic disease. We studied the impact of incidentally prescribed statins on high-risk patients with primary central nervous system diffuse large B cell lymphoma (PCNSL). Methods: We used an IRB-approved clinicopathologic database, derived from comprehensive tumor registry data at the Massachusetts General Hospital, to identify all patients diagnosed with primary central nervous system lymphoma (PCNSL) between 1991 and 2007 (n=118). We excluded pediatric patients, patients who did not receive curative treatment and patients who failed to achieve a CR with initial therapy. Automated analysis of billing and medication administration records was used to identify the administration of statins to these patients. We compared the outcome of patients who were receiving statins to controls with PCNSL who did not receive statins. We excluded patients who did not receive statins within the time interval from 6 months prior to 2 years after their PCNSL diagnosis. As only a single statin pt was less than 50 we excluded all pts below this age from the cases and controls. All patients received high dose MTX based therapy. Overall survival (OS) was calculated from the date of first methotrexate. Results: Median age of statin patients was 66 yrs (range 52 – 76); median age of controls was 66 years (range 50 - 86). Nine patients were on atorvastatin, 9 were on simvastatin, 1 each were on pravastatin, rosuvastatin and fluvastatin. At a median follow-up of 47.5 months, concurrent statin therapy was associated with improved OS (62% vs. 37%)(p=0.04 Log-rank test). The median OS for all statin patients > 50 years old (n=21) was 60 months versus 37 months for all other patients > 50 years old (n=67) (p= Conclusions: Concurrent prescription of HMG-CoA reductase inhibitors is associated with improved outcome in patients with high risk PCNSL compared to controls. Prospective controlled trials will be required to validate this observation. Disclosures: Hochberg: Amgen: Speakers Bureau; Biogen-Idec: Speakers Bureau; Genentech: Speakers Bureau; Enzon: Speakers Bureau.
Fresh produce sanitization by combination of gaseous ozone and liquid sanitizer

Abstract The effect of different combinations of gaseous ozone and Pro-San L against Escherichia coli on baby spinach was investigated. Three different ways to combine liquid and gaseous sanitizer application were compared. The most effective combination was the initial spray application of Pro-San L (0.66% Citric acid, 0.036% SDS) followed by vacuum cooling and ozonation under pressure of 68.9 kPa (10 PSIG) which reduced E. coli O157:H7 counts by 3.9 log CFU/g. Spray application of Pro-San L after the gaseous ozone injection under vacuum followed by immediate system pressurization to 68.9 kPa was less effective (2.7 log CFU/g reduction) due to vacuum internalization of bacteria deeper into produce tissue. This method was not significantly different from a single application of liquid sanitizer. Spray Pro-San L application followed by a long term (up to three days) gaseous ozone treatment decreased microbial load to an undetectable level after the first day of application. However the increase of exposure time to sanitizers led to some damage of spinach leaves. Long term combination liquid-gaseous sanitizer treatment resulted in better appearance of fresh produce than a single application of liquid and gaseous sanitizers.
The effect of education on prejudice as revealed by a game situation

It was proposed that white, southern Ss would reveal prejudice by competitive rather than cooperative behavior in a game and that college experience would be related to less prejudice. Twenty female college juniors and 20 non-college females matched for age and background played a potentially competitive game against a hypothetical white or Negro opponent. Ss showed significantly more competition and aggression against Negro ‘opponents’ than white. College experience apparently made no measurable difference in this behavior.
IMPORTANCE OF SAMPLING NYMPHS IN THE EVALUATION OF INSECTICIDES FOR THREECORNERED ALFALFA HOPPER (HOMOPTERA: MEMBRACIDAE) CONTROL

Results of field insecticide efficacy studies for control of the threecornered alfalfa hopper, Spissistilus festinus (Say), in soybean, Glycine max (L.) Merrill, indicated that sampling of nymphs a...
How Should a Stigmatized Diagnosis Be Conveyed? How What Went Wrong Is Represented in Swallow Me Whole

This essay considers the ethical problems raised by a scene of diagnosis presentation in Nate Powell's graphic novel Swallow Me Whole, in which the patient is not only not engaged by the physician, but also effectively marginalized from the moment that her condition is named and medicalized. Put in the context of the book as a whole and in relationship to the unique affordances of the comics form, however, we see that though the physician made a correct diagnosis, the case did not end well due to the poor delivery of that diagnosis and the lack of support from members of the patient's extended community.
A Review of Magnetoencephalography and Magnetic Evoked Fields

ABSTRACT.In 1978 this author (Hughes 1978) published a short review on some early studies (Cohen 1972; Hughes et al. 1976; Hughes et al. 1977) in magnetoencephalography (MEG) and in 1983 provided an update (Hughes 1983) when many more publications became available. The present review is now required since there has been an exponential increase in interest and number of MEG investigations within the past five years.
An Algorithm for Generating Individualized Treatment Decision Trees and Random Forests

With new treatments and novel technology available, precision medicine has become a key topic in the new era of healthcare. Traditional statistical methods for precision medicine focus on subgroup ...
Mission Impossible: A Legislative Solution for Excessive Executive Compensation

One of the great dilemmas of corporate law is how to address the problem of excessive executive compensation without replacing it with excessive government intervention. This Article proposes for the first time that Article 36(b) of the Investment Company Act ("ICA"), which enacted fiduciary obligations for investment advisers, be applied to general public corporations. The effect of this proposal — termed Corporate 36(b) — would be to impose upon CEOs and other highly placed corporate executives a fiduciary duty with regard to their compensation packages. This would enable federal courts to genuinely evaluate the procedural and substantive nature of executive compensation negotiations. As scholars, the media, and politicians have pointed out, excessive executive compensation reduces shareholder wealth, increases hostility in the workplace, and provokes societal anger. The Article demonstrates that the legislative history of the ICA supports the application of its principles to general corporations. It further shows that the courts’ implementation of the ICA can be replicated in the context of general corporations. The Article argues that adoption of Corporate 36(b) will help to reduce executive demands, to empower and incentivize boards of directors, and to avoid undesirable federal regulation. The Article also addresses potential criticisms concerning the risk of nuisance suits and strike litigation, the vagaries of involving courts in business decisions, and the problems surrounding federalization of corporate law. The Article concludes with a brief description of how the proposed legislation could have been applied to deal with the controversial compensation package in the well-known case of Disney’s hiring and firing of Michael Ovitz.
Introgression of genes for quantitative traits into oat populations

It has been suggested that the high level of adaptation present in today's crop varieties has been attained at the cost of a serious loss of genetic variability. Furthermore unplanned introduction and inadequate sampling may have limited the germ plasm which plant breeders have used and exploited. The purpose of this study was to estimate means and genetic variability among segregates from hybrid combinations between Corn Belt oat varieties and exotic lines. The crosses were made in various combinations and in single, three-way, and more complex crosses to provide information for knowledgeable planning of a breeding program designed to increase the quantity of useful variability in oat breeding populations.
Peripheral Nerve Sheath Tumors: Diagnosis Using Quantitative FDG-PET

Malignant peripheral nerve sheath tumors (MPNST) compose a fraction of all soft tissue sarcomas, but are life-threatening and present difficult diagnostic and therapeutic challenges. Benign peripheral nerve sheath tumors, including schwannomas or neurofibromas, can often be managed conservatively unless symptomatic. MPNSTs require aggressive multimodality treatment (surgery, radiation therapy, ± chemotherapy). MPNSTs can arise from pre-existing neurofibromas in patients with neurofibromatosis type 1 (NF1) or can develop sporadically in the general population. Peripheral nerve sheath tumors are often pathologically heterogeneous or in difficult anatomic locations often making needle biopsy unreliable or unfeasible. Current standard imaging of these tumors rely on computed tomography (CT) or magnetic resonance imaging (MRI), both of which characterize size and local invasiveness, but do not provide reliable insight into the presence of malignant transformation. Clinical manifestations of malignant transformation classically rely on reported symptoms of new neurological deficits, rapid increase in size, change in palpated density from soft to hard, and unremitting pain. Investigations into the glycolytic phenotype of peripheral nerve sheath tumors with [18F] 2-Fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) have been performed to identify potential areas of malignant degeneration. Lower tumor FDG uptake has proven to correlate with benign peripheral nerve sheath tumors, which can be distinguished from the high FDG uptake of its malignant counterpart, MPNST. Clinicians may employ this imaging modality to help identify MPNSTs, guide biopsies, direct therapies, measure response to treatment, and survey for tumor recurrence.
Developing Pupils’ Learning Through the Use Of Mantle Of The Expert

It has been both a pleasure and a privilege to have been involved with the development of Mantle of the Expert since 1991 when Dorothy Heathcote ran the Mary Morgan Project (see Archives A series, Birmingham City University) at Cape Primary School in Smethwick, West Midlands. Over 19 years have passed since then I have watched the system develop and grow from strength to strength. It is now recognised as a major vehicle to teach the curriculum in a highly creative and meaningful manner. Mantle of the Expert has a significant impact on the types of learning experienced by pupils as it provides opportunities for pupils to not only acquire academic knowledge but also the skills needed for the world of work. Lave (1988) states that knowledge needs to be presented in authentic contexts, setting and situations that would normally involve that knowledge. He argues the case that social interaction and collaboration are essential components of situated learning, pupils become involved in a ‘community of practice’ which embodies certain beliefs and behaviours to be acquired. As a novice moves from the periphery of a community to its centre, he or she becomes more active and engaged within the culture and eventually assumes the role of an expert. Never has the time been more appropriate than now to focus on implementing this method of pedagogy as globally, the media informs us that students are not ready to cope with demands of the work place (Onyekakeyah, 2009).
Recurrent Ossifying Epulis in a Dog

A seven-year-old neutered/male Siberian Husky-cross dog was referred for evaluation of a gingival mass. Two years previously, the referring veterinarian had resected an ossifying epulis from the same area between the maxillary left first and second premolars. The neoplasm recurred 4-months after the original surgery. En bloc resection provided tumor-free margins. An oral examination 12-months following surgery indicated no gross signs of recurrence.
Social and Cultural Capital for Students with NVLD: The Transition to College

The interaction of multiple ecological systems such as the individual, family, and school will influence and adolescent’s developmental trajectory into adulthood (Bronfenbrenner, 1974, 1986). Young adults with a foundation of positive traits in these domains will be best prepared for the transition to college and future independence. However, for some adolescents with nonverbal learning disorder (NVLD), the transition to independence can present challenges. Resilience traits that youth develop over time will have a significant effect on developmental outcomes (Rutter, 1987). For those who plan to attend college some predictive traits of those students who will be successful include a good academic self-concept, high educational aspirations, positive mental health, emotional maturity, independent living, and self-advocacy skills. These attributes will not only impact the initial transition to college but can later have a positive effect on retention, graduation, and employment outcomes for adults with NVLD (Brodeur, 2006; Smith, English, & Vasek, 2002; Wehmeyer & Palmer, 2003; Yu, Xiu-Zhu, Ai-Shu, & Zhang, 2008).
Another Example: Successive Polarization Filters for Beams of Spin s= 1/2 Particles

So far, our first example of a unitary transformation from one basis to another involved a finite-dimensional unitary submatrix. Let us consider one more example of this type, an even simpler example involving spin s = 1/2 particles, hence, a 2 × 2-dimensional transformation. Suppose we have a beam of spin s = 1/2 particles. They can be prepared, so all are in a state of definite spin orientation, say, with m s = +1/2, or with m s =− 1/2, along some specific z-direction in 3-D space by passing the beam through a polarization filter. The historically first such filter is that employed by Stern and Gerlach involving a set of three magnets, with nonuniform magnetic fields, placed in succession along the beam line, so a set of baffles can eliminate the particles with one of the two spin orientations. Other types of sophisticated polarization filters exist. (For a reference to modem polarization filters, see, e.g., Polarized Beams and Polarized Gas Targets, Hans Paetz gen. Schieck and Lutz Sydow, eds. World Scientific, 1996). We will assume the filter is perfect and prepares particles in a pure state of very definite m s along a specific z-direction. Suppose the first such filter is followed with a second filter, identical to the first, but now with its new z’ axis oriented along some new direction, given by polar and azimuth angles, θ and φ, relative to the original x, y, z axes, and set for some definite m’s along the new direction. What fraction of the s = 1/2-particles will pass through the second filter?
Reasons for nonadherence and response to treatment in an adherence intervention trial for relapsing–remitting multiple sclerosis patients

Objectives To explore whether patients in an adherence trial who appeared not to take disease modifying therapy (DMT) for avoidance reasons could be reliably identified, by observational coding, for their main reason of not taking DMT. To determine whether reason groups could be distinguished by clinical and self-report psychological characteristics and intervention outcomes. Method Participants were multiple sclerosis patients (N = 78, 88.5% female, mean age 45.64) demotivated to take DMT. Audio recordings of the sessions were coded for the main reason of not taking DMT. Reason groups were compared based on patient characteristics and intervention outcomes. Results Avoidance and three other reasons for not taking DMT (side effects, cost, and mild course) were reliably identified (κ = 0.88). Patient characteristics failed to distinguish participants in the Avoidance group, which also had poorer outcomes (X2 [2, n = 73] = 6.35, p = 0.036). Conclusions Patients not taking DMT for avoidance reasons may need novel methods to identify them and encourage (re-)initiation.
Effect of Cold Storage and Pre-transplant Desiccation on Root Growth Potential and Bud Break of Bare-root Washington Hawthorn and Norway Maple

Abstract Two-year-old Washington hawthorn (Crataegus phaenopyrum Med.) and Norway maple (Acer platanoides L.) seedlings were subjected to varying cold storage durations and 4 storage treatments: whole plant covered, shoots exposed, roots exposed and whole plant exposed. After storage, half the seedlings were immediately planted and half received a 12-hr desiccation treatment prior to transplanting. Root growth potential (RGP), time to bud break, and marketability were measured. With the root covered treatments, Norway maple RGP increased, while Washington hawthorn RGP decreased with increased cold storage duration. RGP for both species remained low throughout storage for treatments exposing roots. The 12-hr desiccation treatment reduced RGP for both species with hawthorn being more affected than maple. Days to bud break for both species decreased with increased storage time for whole plant covered treatments, but increased for both species when stored with exposed roots. Maple marketability for root cover...
Factors Affecting the Regiochemical Outcome of Alkene Insertions into Rhodium–Carbon and Rhodium–Nitrogen Bonds

Density functional theory was used to analyze the factors affecting the regiochemical outcome of the insertion of the substituted alkene (CH2CHR, R = CN, Ph, Me, NH2) into the rhodium–carbon or rho...
Towards Marrying Files to Objects.

To deal with the constant growth of unstructured data, vendors have deployed scalable, resilient, and cost effective object-based storage systems built on RESTful web services. However, many applications rely on richer file-system APIs and semantics, and cannot benefit from object stores. This leads to storage sprawl, as object stores are deployed alongside file systems and data is accessed and managed across both systems in an ad-hoc fashion. We believe there is a critical need for a transparent merger of objects and files, consolidating data into a single platform. Such a merger would extend the capabilities of both object and file stores while preserving existing semantics and interfaces. In this position paper, we examine the viability of unifying object stores and file systems, and the various design tradeoffs that exist. Then, using our own implementation of an object-based, POSIX-complete file system, we experimentally demonstrate several critical design considerations.
Evaluation of nitro compounds as feed additives in diets of Eimeria-challenged broilers in vitro and in vivo.

Abstract Coccidiosis is a disease caused by Eimeria spp., resulting in approximately 3 billion US dollar loss in the poultry industry annually. The present study evaluated the effects of potential feed additives, 2-Nitro-1-propanol (NP) and nitroethanol (NE), on control of coccidiosis. An in vitro experiment indicated that both NP and NE inhibited the development of sporozoites in Madin-Darby bovine kidney cells (MDBK). The in vivo study was further conducted to evaluate the effects of NP and NE on growth performance, nitrogen-corrected apparent metabolizable energy (AMEn), and intestinal lesion scores of broilers challenged with Eimeria spps. Six treatments were tested in the study, including the nonchallenged control, challenged control, 100 ppm NP, 200 ppm NP, 100 ppm NE, and 200 ppm NE. Broilers were fed the treatment diets from day 12 until the end of the trial. All birds except the unchallenged control were challenged with Eimeria maxima, Eimeria tenella, and Eimeria acervulina on day 14. The growth performance was calculated, and the intestinal lesion was scored on day 20. The results showed that Eimeria challenge significantly reduced growth performance, increased intestinal lesion scores, and decreased AMEn compared with the nonchallenged control group. Birds fed with 200 ppm of NP had reduced growth performance compared with the nonchallenged control and challenged control. However, the supplementation of NP significantly improved AMEn and reduced cecal damage. Overall, NP and NE reduced sporozoites numbers in the MDBK cells. NP improved dietary digestibility of energy and reduces lesion scores in the ceca but could not maintain growth performance in broiler chickens infected with Eimeria spp.
ONE MONTH DUAL ANTIPLATELET THERAPY IN HIGH BLEEDING RISK PATIENTS: PRIMARY RESULTS FROM THE ONYX ONE CLEAR STUDY

High bleeding risk (HBR) patients undergoing percutaneous coronary intervention may require shorter durations of dual antiplatelet therapy (DAPT). The randomized Onyx ONE trial compared the Resolute Onyx zotarolimus-eluting stent with a polymer-free drug-coated stent in HBR patients with 1-month
Outcomes with temporary mechanical circulatory support before minimally invasive centrifugal left ventricular assist device.

Background Despite improved survival and morbidity after durable left ventricular assist device (dLVAD), outcomes for cardiogenic shock patients are suboptimal. Temporary mechanical circulatory support (tMCS) can permit optimization before dLVAD. Excellent outcomes have been observed using minimally-invasive dLVAD implantation. However, some feel tMCS contraindicates this approach. To evaluate whether left thoracotomy/hemisternotomy (LTHS) dLVAD placement is safe in this setting, we compared patients who did and did not require tMCS. Methods Outcomes for patients receiving dLVADs via LTHS were compared among those bridged with extracorporeal membrane oxygenation (ECMO), intra-aortic balloon pump (IABP), or no tMCS. We evaluated demographics, comorbidities, laboratory and hemodynamic data, and intraoperative and postoperative outcomes. Results Eighty-three patients underwent LTHS dLVAD placement. Fifty did not require tMCS, while 22 (26%) required IABP, and 11 (13%) ECMO. Non-tMCS patients were primarily Intermacs 3 (56%), while IABP recipients were mainly Intermacs 2 (45%). All patients with ECMO were Intermacs 1. Patients with tMCS had worse end-organ function. Operative outcomes were similar except more concomitant procedures and red-cell transfusions in patients with ECMO. Intensive care unit and hospital length of stay and inotrope duration were also similar. There were no differences in bleeding, stroke, and infection rates. Three- and 12-month survival were: no tMCS: 94%, 86%; IABP: 100%, 88%; and ECMO: 81%, 81% (P = .45). Conclusions Patients with cardiogenic shock can safely undergo LTHS dLVAD implantation after stabilization with ECMO or IABP. Outcomes and complications in these patients were comparable to a less severely ill cohort without tMCS.
On the mechanism by which nose bluntness suppresses second-mode instability

ABSTRACT A physical mechanism by which nose bluntness suppresses second-mode instability is proposed. Considered are 7 degree half-angle straight cones with nose bluntness radii of 0.15 mm, 3.556 mm, 5 mm, 9.525 mm, 12.7 mm and 25.4 mm at tunnel conditions relevant to the AFOSR-Notre Dame Large Mach 6 Quiet Tunnel. It is shown that second-mode suppression is achieved via entropy layer modulation of the basic state density gradient. A weakening of the density gradient disrupts the acoustic resonance necessary to sustain second-mode growth. These results are consistent with the thermoacoustic interpretation which posits that second-mode instability can be modeled as thermoacoustic resonance of acoustic energy trapped within an acoustic impedance well. Furthermore, the generalized inflection point criterion of Lees and Lin is applied to develop a criterion for the existence of second-mode instability based on the strength of the basic state density gradient.
The Thermodynamic and Electrical Properties of The H-C-N-O-K System

ABSTRACT This paper describes the results of a program written for use on the IBM 709 Computer to calculate the thermodynamic properties of a mixture of dissociating combustion gases. This program computes the equilibrium properties (enthalpy, entropy, molecular weight) of any system involving arbitrary amounts of carbon, oxygen, hydrogen, nitrogen and an inert gas over a wide range of temperatures and pressures. Included in this paper are the results, in the form of Mollier charts, for ten typical compositions. Since such a mixture of combustion gases, to which a small amount of easily ionizable substance may be added, shows promise as the working fluid in low-temperature magnetohydrodynamic machines, it is desirable to know also its electrical conductivity. This was calculated for 1%, 3%, and 10% potasium additive over a wide range of temperatures and pressures, and again the results are presented in graphical form. For all the calculations, the presence of solids, negative ion formation, and chemical reaction of the seed material with the combustion gases were neglected. Thus, since constant values of the collision cross sections were used, lines of constant electrical conductivity could be superimposed directly on the Mollier charts; an example is included.
Patient navigation in epilepsy care.

Abstract The concept of patient navigation was first introduced in 1989 by the American Cancer Society and was first implemented in 1990 by Dr. Harold Freeman in Harlem, NY. The role of a patient navigator (PN) is to coordinate care between the care team, the patient, and their family while also providing social support. In the last 30 years, patient navigation in oncological care has expanded internationally and has been shown to significantly improve patient care experience, especially in the United States cancer care system. Like oncology care, patients who require epilepsy care face socioeconomic and healthcare system barriers and are at significant risk of morbidity and mortality if their care needs are not met. Although shortcomings in epilepsy care are longstanding, the COVID-19 pandemic has exacerbated these issues as both patients and providers have reported significant delays in care secondary to the pandemic. Prior to the pandemic, preliminary studies had shown the potential efficacy of patient navigation in improving epilepsy care. Considering the evidence that such programs are helpful for severely disadvantaged cancer patients and in enhancing epilepsy care, we believe that professional societies should support and encourage PN programs for coordinated and comprehensive care for patients with epilepsy.
Module Identification of Biological Networks via Graph Partition

Complex biological systems can be characterized by biological networks. For example, gene co-expression networks encode relationships between genes, where genes with similar expression profiles are connected to each other. A gene regulatory network is a collection of transcription factors that interact with other genes in the cell to govern the gene expression levels of mRNA and proteins. Obviously, systematic analysis of these biological networks could help us to have a better understanding of the functional organization of the corresponding biological systems and further uncover the underlying biological mechanisms.
Targeting MSS colorectal cancer with immunotherapy: are we turning the corner?

Immunotherapy with checkpoint inhibition has shown potent antitumor activity in patients with microsatellite instability (MSI) metastatic cancer. Microsatellite stable (MSS) colorectal cancer has l...
Researching & Teaching Political Science Through Arts-Based Inquiry Methods

Arts-based research (ABR) helps bridge the gap between science and the humanities with attention to creativity, critical analysis, and aesthetic expression, and offers transdisciplinary and holistic ways to examine complex political problems. This chapter describes use of the photo essay as a visual inquiry method to augment quantitative and other qualitative choices political science students typically face when tasked with research projects. It recounts rationale, design and outcome of a photo essay assignment for an undergraduate course about human security. It argues that incorporating ABR approaches into research design/methods curriculum can build visual competences and cultivate fresh perspectives by fostering systematic observation and interpretive analysis of imagery. In short, arts-based research design holds much promise for enlivening and enlarging student learning experiences in political inquiry.
Why This Book Is Needed

A conceptual introduction sets forth the book’s aim: to guide clinical social work students (and practicing clinicians) to explore assessment from a range of theoretical frameworks, each with its own emphasis, limitations, and form of evidence, and to think critically about what each perspective has to offer, takes for granted, omits, and counts as knowledge. It begins by exploring the meaning of the key terms “critical thinking,” “diagnosis,” and “assessment” and draws on both theory and research to trace how these concepts have been addressed in social work education and practice. Following an overview of the book’s structure and content, including introduction to the case of Ray (a case that will be used throughout the chapters and analyzed from each clinical perspective), the introduction concludes with specific suggestions for educators about ways to use the book to develop complex, reflexive, and critical thinking in their students.
Isometric Extensions of zero entropy ℤ^{} Loosely Bernoulli Transformations

In this paper we discuss loosely Bernoulli for Zd actions. In particular, we prove that extensions of zero entropy, ergodic, loosely Bernoulli Zd actions are also loosely Bernoulli.
Experimental Approaches to Joint Forest Production

This chapter examines large-scale management experiments in joint production of forest resources. This is a somewhat limited body of knowledge, mostly because the emphasis on joint production of multiple products and values from the forest is so recent (Stevens and Montgomery 2002). Large-scale management experiments emphasize joint production and alternatives to clearcutting, therefore they lie at the heart of compatible forest management. Scale becomes an issue because compatibility is easier to reach at larger scales, such as the watershed or the landscape (Haynes and Monserud 2002). Classical experimentation (using randomization, replication, and controls) in ecological management, at scales as large as a landscape is nearly impossible because of logistical and administrative problems (Carpenter 1998, Monserud 2002). Therefore, I begin at the scale of the forest stand, the unit of forest management, and then move on to the watershed scale.
A Design Based Introduction to Electrical Engineering

This freshman course has four objectives: to establish a feeling of "belonging" to electrical engineering; to provide an overview of the electrical engineering field and the options available; to teach basic circuit concepts; and to elicit creative thinking in the students. The class meets twice a week for an hour and a half and carries one credit hour. The course itself, by being at the freshman level, provides the desired electrical Engineering Department home base. The overview is provided by presentations, demonstrations, and limited hands-on experiences in the various options. Objectives three and four are realized in a series of logical design exercises using switches and relays. At the end of the course, the students feel at home in the EE department; they have learned to function effectively on design teams; they have acquired some basic circuit concepts; and they have used analytical and creative thinking processes.
Packaging of Food Products

Packaging is intended to preserve food against spoilage and contamination and extend its shelf life. The various packaging materials, including films and, package oxygen protect foods from such variables as light and moisture. Packaging may also maintain time-sensitive foods. Yet, packaging offers much more than these benefits to the manufacturer and consumer. It provides containment (holding the product), protection (quality, safety, freshness), information (graphics, labels), and utility of use or convenience (1).
Seasonal and Rotational Influences on Corn Nitrogen Requirements

This project was designed to study the N fertilization needs in continuous corn (CC) and corn rotated with soybean (SC) as influenced by location and climate. Multiple rates of fertilizer N were spring applied, with the intent to measure yield response to N within each rotation on a yearly basis for multiple years at multiple sites across Iowa. This will allow the determination of N requirements for each rotation, differences that exist between the two rotations, responses to applied N across different soils and climatic conditions, and evaluation of tools used to adjust N application.
Experimental study of acid burden and acute oesophagitis.

Background The relationship of the pH of oesophageal refluxate and its pepsin content to injury of oesophageal mucosa remains unclear. A study was made of the earliest morphological alterations in the oesophageal mucosa secondary to varying concentrations of hydrochloric acid with or without pepsin. Methods Adult cats had varying concentrations of acid with and without 1 per cent porcine pepsin infused into the oesophagus through a paediatric feeding tube placed 5 cm above the oesophagogastric junction at a rate of 1 ml/min for 30 min. At autopsy 24 h later, the oesophagus was removed intact and scored by an expanded modification of a previously published histopathological scoring system. This included estimates of the intensity and distribution of four morphological features: basal cell hyperplasia (BCH), intraepithelial leucocytes (IELs), subepithelial leucocytes and ulcers. Each of these four categories was scored from 0 to 4, with a maximum injury score of 16. Results Mean(s.e.m.) scores were as follows: pH 1, 15·0(1·0); pH 1 with pepsin, 13·3(1·4); pH 2, 15·3(0·7); pH 2 with pepsin, 11·7(1·1); pH 3, 1·8(1·6); pH 3 with pepsin, 3·7(1·9); pH 4 with or without pepsin, 0·6(0·2). Differences between pH 3 and 4 versus pH 1 and 2 were significant (P<0·05). Conclusion Injury to the oesophagus is more dependent on the pH of refluxate than on the presence of pepsin. Peptic injury appears to occur at a critical threshold of acid burden (pH<3) as opposed to a graded level of injury based on a pH scale. © 1998 British Journal of Surgery Society Ltd
The vocabulary of madness from Homer to Hippocrates. Part 2: The verbal group of βακχεύω and the noun λύσσα

In Part 2 of this two-part paper, I examine the evolution and the aspects of the concept of madness expressed by the various forms — verbal and nominal, simple and compound — of the verbal group of βακχeύω and the noun λύσσα, its nominal and derivatives, in the archaic and classical periods. I conclude that the verbal group of βακχeύω is apt to indicate bacchic frenzy that manifests either in the celebration of Bacchos’s mysteries or in the delirium instilled by Dionysos In addition, λύσσα, its nominal and verbal derivatives, refer to either a violent and wild state of soul resulting from divine intervention or pathological madness caused by a dog’s bite.
Analytic foundations of halo theory

This article develops a unified approach to the computation of refraction ice crystal halos and their caustics. An explicit formula is given for the halo function, that is, the function that expresses points of light on the celestial sphere as a function of crystal orientation. Restricting the halo function to various subsets of its domain produces different halos. The caustic of a halo is the image of the set of singular points of the (suitably restricted) halo function. Computation of the kernel of the Jacobian of the unrestricted halo function leads to a general approach to the construction of caustics of arbitrary halos. The halos used as examples are circular halos, upper and lower tangent arcs, infralateral and supralateral arcs, Lowitz arcs, and parhelia. The above methods are used to generate computer plots of several of these halos and their caustics, together with the sets of crystal orientations responsible for the halos.
Acetylcholine biosensors based on layer-by-layer self-assembled polymer/nanoparticle ion-sensitive field-effect transistors

Abstract In this paper, the fabrication and characterization of acetylcholine biosensors based on nano self-assembled ion-sensitive field-effect transistors (ISFETs) are demonstrated. The fabrication is implemented with a very low-cost layer-by-layer nano self-assembly technique. The self-assembled polyaniline thin films work as the semiconducting channel material, while silicon dioxide (SiO 2 ) nanoparticle thin films serve as the gate dielectric material. Both the silicon wafer and flexible plastic transparency have been applied as the substrate materials. A polyaniline ISFET on silicon wafer operates at a low-voltage range and has a mobility of 1.49 cm 2 /V s. Acetylcholine in a concentration as low as 1 μM could be detected with this sensor. A polyaniline ISFET on plastic substrate could detect acetylcholine concentration down to 10 μM. The results presented in this paper suggest a route to fabricate inexpensive and flexible ion-sensitive field-effect transistors for biosensing applications.
Computer Simulation of Interarticular Fluid Flow

A computer simulation of the human hip joint behaviour in the dynamic regime of walking was performed based on the geometry and the relevant dynamic constitutive properties of the cartilage layers in a particular joint. These were established in vitro, in situ by de nuovo techniques developed in this laboratory. Presented in this paper are the simulation results describing the fluid flow patterns within the interarticular space. Simulation generated flow patterns appear well correlated to split-line patterns on the femoral head. Hence our proposition that enhancement of the superficial layer anisotropy by the fluid flow and consequent reduction of the interarticular sealing is the primary mechanical aspect of the synovial joint degradation.