cssi/SciSciGPT-SciSciNet huggingface dataset:
Clinical Presentations And Mechanisms Of Necrotizing Angiitis Of The Skin

Cutaneous necrotizing angiitis may be present as either palpable purpura or less commonly as recurrent urticaria, and each clinical presentation may be associated with hypocomplementemia or a normal complement system. A variety of mechanisms may be operative in the production of necrotic vascular skin lesions that appear as similar, recognizable morphologic lesions. These mechanisms include immune complexes, cellular-type hypersensitivity reactions, and initiation or modulation by mast cells. Two cellular patterns have been recognized in the skin of patients with cutaneous necrotizing angiitis that can be correlated with the involvement of the complement system in serum. In patients with hypocomplementemia, there is an infiltrate of neutrophils that is consistent with a process involving immune complexes; in patients with normocomplementemia there are lymphocytes and activated lymphocytes consistent with participation in part by cellular mechanisms. In both the hypocomplementemic and normocomplementemic forms and as well as in a unique patient in whom the mast cell may initiate the venular damage, the mast cell, which its content of chemical mediators, has the capacity to initiate as well as modulate subacute and chronic vascular damage.
Reliability of the color analog scale: repeatability of scores in traumatic and nontraumatic injuries.

Objectives: The objective was to assess in a pediatric emergency department (ED) the reliability of the color analog scale (CAS) for acute pain assessment, overall and between traumatic and nontraumatic pain etiology. Methods: This was a prospective study of children aged 5 to 16 years in the ED of a children’s hospital who had a complaint of pain. The CAS was administered to the patient at admission and at 30 minutes. To evaluate repeatability, a second measurement was obtained 1 minute following each assessment. This assumed there would be no substantial change in pain intensity within 1 minute. The authors used the intraclass correlation coefficient (ICC) to evaluate the repeatability of 1-minute interval measurements. Results: A total of 170 patients were enrolled. The origin of pain was traumatic in 81 cases (48%). Regardless of pain etiology, the CAS scores were highly repeatable (r = 0.97, 95% confidence interval [CI] = 0.95 to 0.98). Conclusions: The color analog scale is both a valid and a reliable self-reporting tool in the assessment of acute pain in children.
Composition of R&D and technological cycles

Abstract This paper investigates the existence of ‘technological cycles’ that arise endogenously from certain tradeoffs between research and development inherent in the technological features of R&D production. It analyzes the composition of R&D expenditures and models the associated internal structure and dynamics of the innovation process explicitly. The model includes externalities and cumulative aspects of R&D processes. The discussion is initially developed in a deterministic setting for both the first-best and the market cases. The dynamics leading to optimal cycles are fully explored. For specific examples, results are given with regard to 1. i) level of research investment, 2. ii) stability of steady states and cycles, and 3. iii) amplitude of cycles. Extensions to a stochastic setting are also presented.
Infrared Wavefront Control Based on Graphene Metasurfaces

Metasurfaces, a new class of planar metamaterial, are attracting intensive attention due to their exceptional abilities to mold light. In this work, novel metasurfaces based on graphene nanoribbons are developed to control the wavefront of infrared light. The results show that these metasurfaces can create phase discontinuities between incident and scattered light, covering the phase range from 0 to about π while maintaining a relatively large amplitude for the scattered light. A cylindrical flat lens and anomalous refraction based on graphene nanoribbon metasurfaces are also demonstrated, paving the way to developing graphene-based tunable devices for infrared wavefront control.
Hypoplastic left heart syndrome with intact atrial septum: levoatriocardinal vein stent placement as a bridge to surgery.

Infants with hypoplastic left heart syndrome, an intact atrial septum and pulmonary venous hypertension, are critically ill and have a poor prognosis. This case describes relief of severe pulmonary edema in such a patient by stent placement in a stenotic levoatriocardinal vein, with subsequent successful surgical palliation.
C-erb B-2 amplification in cystic renal disease.

C-erb B-2 amplification in cystic renal disease. Gene amplification (overexpression) of c-erb B-2 was tested in a variety of cystic renal diseases, renal cell neoplasms (adenomas and carcinomas) and end stage kidneys without cysts C-erb B-2 encodes a receptor-like protein that shares homology with, but is distinct from the epidermal growth factor (EGF) receptor. A monoclonal antibody that immunoprecipitates a protein of approximately 185 kD from a lysate of NIH/3T3 cells transfected with the c-erb B-2 gene was utilized for testing. Simple renal cysts, cystic renal dysplasia, autosomal recessive polycystic kidney disease (ARPKD), and non-cystic, essentially normal kidneys failed to show c-erb B-2 overexpression. In contrast, autosomal-dominant polycystic kidney disease (ADPKD), acquired (dialysis-associated) cystic disease (ACD), non-cystic end stage kidneys and renal cell neoplasms revealed overexpression of c-erb B-2 with some frequency (40% or more of cases tested). Three cystic disorders revealing c-erb B-2 overexpression also showed platelet-derived growth factors (PDGFs) expression in similar locations (cyst lining and adjacent tubules). Other growth factors [insulin-like growth factor (IGF-I), fibroblast growth factor (FGF) and beta transforming growth factor (TGFβ)] were not noted to be overexpressed in either c-erb B-2 positive or negative cystic diseases C-erb B-2 may be a marker related to the proliferative/growth capabilities of selected cystic diseases, including potential for associated genesis of benign and malignant renal cell tumors.
Conductivity analysis for free fatty acids in oil from glandless cottonseed

Attempts to determine free fatty acids in petroleum ether extracts of cottonseed and crude cottonseed oil by conductivity measurements were unsuccessful due to interference of gossypol. With new strains of glandless cottonseed, which do not contain gossypol, analysis of free fatty acids by conductivity was successful on both the petroleum ether extracts and on the crude oil. An important advantage of conductivity over titration is that sample preparation is eliminated, since conductivity measurements are made on the oil extracts from the total oil determination.
A thin film approach for producing mineral diffusion couples

Few diffusion coefficient values have been measured for silicate minerals at pertinent geologic conditions because of experimental restrictions. Until recently, analysis of diffusion couples was conducted principally with electron microprobes which have rather poor spatial resolution (micrometer scale). Ion microprobe analyses, however, eliminate many of the previous experimental restrictions; in depth profile mode they have excellent spatial resolution (tens of angstroms) and diffusion couples can be analyzed normal to the interface. Diffusion couples analyzed by ion microprobe must be well-defined and uniform; previous methods using solution precipitates to form the diffusion couples were heterogeneous and had limited success. A new approach, the thermal evaporation of 25MgO under high vacuum onto a crystalline substrate (oxide, silicate), produces a 1000 A thick 25MgO x (x < 1) thin film. This method yields an excellent diffusion couple for low-temperature diffusion experiments. Diffusion anneal experiments using this approach for garnet provide a Mg self-diffusion coefficient of D = 0.60 ± 0.09 × 10−21 m2/s at 1000°C (logfO2 = −11.3, P = 1 atm, X Almandine = 0.24).
Regional impacts of ocean color on tropical Pacific variability

Abstract. The role of the penetration length scale of shortwave radiation into the surface ocean and its impact on tropical Pacific variability is investigated with a fully coupled ocean, atmosphere, land and ice model. Previous work has shown that removal of all ocean color results in a system that tends strongly towards an El Nino state. Results from a suite of surface chlorophyll perturbation experiments show that the mean state and variability of the tropical Pacific is highly sensitive to the concentration and distribution of ocean chlorophyll. Setting the near-oligotrophic regions to contain optically pure water warms the mean state and suppresses variability in the western tropical Pacific. Doing the same above the shadow zones of the tropical Pacific also warms the mean state but enhances the variability. It is shown that increasing penetration can both deepen the pycnocline (which tends to damp El Nino) while shifting the mean circulation so that the wind response to temperature changes is altered. Depending on what region is involved this change in the wind stress can either strengthen or weaken ENSO variability.
Expression and characterization of human salivary statherin from Escherichia coli using two different fusion constructs.

Saliva is a supersaturated solution with respect to hydroxyapatite, the main inorganic component of tooth enamel. Several acidic phosphoproteins are present in saliva which allow the supersaturated state to be maintained without random crystallization occurring. Statherin is the only salivary protein currently known to inhibit both the primary and secondary precipitation of hydroxyapatite in the supersaturated environment of saliva. To identify the residues of statherin that are necessary to control biomineralization, a recombinant form of human statherin was produced from Escherichia coli using a yeast intein fusion construct. The primary structure of the recombinant statherin was characterized by SDS-PAGE, N-terminus sequencing, MALDI mass spectrometry, and amino acid analysis and found to have the expected values relative to human-derived statherin. The secondary structure of the recombinant statherin was investigated by circular dichroism spectroscopy, which revealed the predominant presence of random coil in phosphate-buffered saline solution, with a higher propensity toward alpha helicity in 100% TFE. This increase in helicity in 100% TFE was also found in statherin that was synthesized by solid-phase synthesis. These results demonstrate that human statherin can be produced in a recombinant form which behaves comparably to the natural form.
Methodology for switching characterization evaluation of wide band-gap devices in a phase-leg configuration

Double pulse tester (DPT) is a widely accepted method to evaluate the switching behavior of power devices. Considering the high switching-speed capability of wide band-gap (WBG) devices, the test results become significantly sensitive to the alignment of voltage and current (V-I) measurement. Also, because of the shoot-through current induced by Cdv/dt, during the switching transient of one device, the switching losses of its complementary device in the phase-leg is non-negligible. This paper summarizes the key issues of DPT, including layout design, measurement considerations, grounding effects and data processing. Among them, the latest probes for switching waveform measurement are compared, the methods of V-I alignment are discussed, and the impact of grounding effects induced by probes on switching waveforms are investigated. Also, for the WBG devices in a phase-leg configuration, a practical method is proposed for switching loss evaluation by calculating the difference between the input energy supplied by a dc capacitor and the output energy stored in a load inductor. Based on a phase-leg power module built with 1200 V SiC MOSFETs, the test results show that regardless of V-I timing alignment, this method can accurately indicate the switching losses of both the upper and lower switches by detecting only one switching current.
Shock-fitted multidomain solution of supersonic flows

Abstract Shock fitting is presented as a way to compute shocks with spectral methods. With fitting, spectral approximation is performed on smooth portions of the flow and a precise description of a discontinuous shock is possible. Coupled with spectral domain decomposition, one has the ability to resolve efficiently and without stretching transformations, boundary layers and other regions in the flow where increased local resolution is needed. A supersonic blunt body problem is solved to provide an example of the use of the approach. Comparisons between computations and experimental measurements are made for body surface quantities, shock shape, and body normal direction profiles.
Embolization of Visceral Arterial Aneurysms

This chapter covers aneurysms of the abdominal visceral arteries excluding renal artery aneurysms which are covered in Chapter 40.
The where and how of attention-based rehearsal in spatial working memory.

Rehearsal in human spatial working memory is accomplished, in part, via covert shifts of spatial selective attention to memorized locations (‘‘attention-based rehearsal’’). We addressed two outstanding questions about attention-based rehearsal: the topography of the attention-based rehearsal effect, and the mechanism by which it operates. Using event-related fMRI and a procedure that randomized the presentation of trials with delay epochs that were either filled with a flickering checkerboard or unfilled, we localized the effect to extrastriate areas 18 and 19, and confirmed its absence in striate cortex. Delay-epoch activity in these extrastriate regions, as well as in superior parietal lobule and intraparietal sulcus, was also lateralized on unfilled trials, suggesting that attention-based rehearsal produces a baseline shift in areas representing the to-be-remembered location in space. No frontal regions (including frontal eye fields) demonstrated lateralized activity consistent with a role in attention-based rehearsal. D 2004 Elsevier B.V. All rights reserved. Theme: Neural basis of behavior Topic: Cognition
Timing of congenital dacryostenosis resolution and the development of anisometropia

Background Anisometropia was recently shown to occur in 10% of infants diagnosed with dacryostenosis at a mean age of 1 year. The purpose of this study was to determine whether earlier ( Methods The medical records of all patients diagnosed as infants with dacryostenosis at Mayo Clinic, Rochester, Minnesota, USA, from 1 January 1988 to 31 December 1992 were retrospectively reviewed. Of 662 consecutive infants diagnosed with dacryostenosis, 244 (36.9%) were subsequently examined in the ophthalmology department and included in the study. Each of the study patients was followed through to 30 June 2011. The main outcome measure was the rate of anisometropia (≥1 dioptre between the two eyes) among those who spontaneously resolved and those who underwent surgery. Results Among the 244 cases, 189 (77.5%) spontaneously resolved at a mean age of 4.5 months (range 0.3–35 months), and 55 (22.5%) underwent surgery at a mean age of 16 months (range 0–53 months). Anisometropia was diagnosed in 17 (9.0%) of the 189 who spontaneously resolved and in 2 (3.6%) of the 55 operated children (p=0.19). Although there was no significant trend, earlier resolution was associated with higher rates of anisometropia. Conclusions Early spontaneous resolution of dacryostenosis was more likely to have a higher, not lower, rate of anisometropia than late spontaneous or surgical resolution. Further studies are warranted to clarify the relationship between infantile dacryostenosis and the development of hyperopic anisometropia.
Vapor−Liquid Equilibria in the Systems Ethyl Lactate + Ethanol and Ethyl Lactate + Water

A simple vapor−liquid equilibrium (VLE) apparatus has been constructed to successfully measure the VLE of binary ethyl lactate systems that have relatively high differences in volatility (P2sat/P1sat ∼ 7.0). Degassing is done in situ, reducing the experimental time considerably. Isothermal VLE of the ethyl lactate + ethanol system was measured at (40.0, 60.1, and 80.2) °C, and the isothermal VLE of the ethyl lactate + water system was measured at (40.0 and 60.0) °C. The ethyl lactate + ethanol system is slightly nonideal, and the ethyl lactate + water system forms a minimum boiling azeotrope. Isothermal data for ethanol + water were measured at 40.0 °C to demonstrate reliability of the apparatus.
Flexibility characteristics of a polyethylene terephthalate chemiresistor coated with a nanoparticle thin film assembly

Polyethylene terephthalate (PET) functions as a flexible substrate for the fabrication of functional devices by low-cost and scalable roll-to-roll manufacturing. Exploration of this attribute for chemical sensors requires understanding of the flexibility characteristics in correlation with the sensing properties in terms of a combination of device strain and molecular interactions in different chemical environments. This report describes new findings of an investigation of the response characteristics of PET chemiresistor sensors coated with a thin film assembly of gold nanoparticles in response to different device strains and adsorption of volatile organic compounds. The work demonstrates that the sensor response characteristics can be tuned by a combination of flexible device strain parameters. A significant finding is that the contribution to the changes in the sensing signals and sensitivities depends on not only the molecular nature of species being detected, but also a combination of the interparticle spatial, dielectric medium, and device strain properties. This combination is also associated with the orientation of the microelectrode patterns with respect to the device strain direction. These findings have an important implication for the design of nanoparticle-coupled flexible chemical sensors for effective detection of chemical or biological species in different sensing environments.
Recent literature on bryophytes — 118(3)

Afonina, O. M. 2015. New moss records from Irkutsk Province. 3. Arctoa 24: 250. Afonina, O. M., V. I. Zolotov & O. V. Lavrinenko. 2015. New moss records from Nenets Autonomous District. 3. Arctoa 24: 224–225. Ah-Peng, C., N. Wilding, J. Kluge, B. Descamps-Julien, J. Bardat, M. S. Chuah-Petiot, D. Strasberg & T. A. J. Hedderson. 2012. Bryophyte diversity and range size distribution along two altitudinal gradients: continent vs. island. Acta Oecologica 42: 58–65. Akatova, T. V. 2015. New moss records from Krasnodar Territory. 8. Arctoa 24: 248. Akatova, T. V. 2015. New moss records from Republic Adygea. 5. Arctoa 24: 248–249. Akatova, T. V. & E. A. Ignatova. 2015. On the moss flora of Lagonaki Highland (Adygea Republic, the Western Caucasus). Arctoa 24: 148–155. Akiyama, H. 2004. Koke no Hanashi: Chiisana shokubutsu no shirarezaru seitai. iv + 216 pp., 4 pls. Chuo Koron Shinsha, Tokyo, Japan. [In Japanese; title translates as Essays on Bryophytes; a less technical book than Akiyama et al. (2002); chapters are:
The Constitution of the White Earth Nation

The Constitution of the White Earth Nation was ratified by sworn delegates on April 4, 2009. The Constitution declares a separation from the current federal constitution that consolidated six Anishinaabe or Chippewa reservations in Minnesota. This federal constitutional association has not served the specific interests of the citizens of the White Earth Reservation. The disposition of treaty land, for instance, and the uses of natural resources cannot equitably be decided by any other government or federation of reservations. Forty citizen delegates were appointed to deliberate the appropriate formation of an independent reservation government. In the past two years after three two-day Constitutional Conventions on the White Earth Reservation, Gerald Vizenor was named the principal writer of the new constitution. The Constitution of the White Earth Nation was ratified at the fourth Constitutional Convention. The ratified Constitution will soon be presented to the citizens of the reservation as a referendum.
International Trade and the Gender Wage Gap: New Evidence from India’s Manufacturing Sector

Summary This study examines how increasing competitive forces from India’s trade liberalization have affected women’s relative wages and employment. Neoclassical theory implies that costly discrimination against female workers should diminish over time with increased competition. We incorporate this idea into a theoretical model of competition and industry concentration and test the model using repeated cross-sections of India’s National Sample Survey Organization (NSSO) household survey data merged with trade and production data from 1983 to 2004. Estimates from ordinary least-squares (OLS) and fixed effects regressions at the industry-level indicate that increasing openness to trade is associated with larger wage gaps in India’s concentrated manufacturing industries.
Space-time kriging extension of precipitation variability at 12 km spacing from tree-ring chronologies and its implications for drought analysis

Abstract. Understanding and preparing for future hydroclimatic variability greatly benefits from long (i.e., multi-century) records at seasonal to annual time steps that have been gridded at km-scale spatial intervals over a geographic region. Kriging is a geostatistical technique commonly used for optimal interpolation of environmental data, and space-time geostatistical models can improve kriging estimates when long temporal sequences of observations exist at relatively few points on the landscape. Here I present how a network of 22 tree-ring chronologies from single-leaf pinyon (Pinus monophylla) in the central Great Basin of North America was used to extend hydroclimatic records both temporally and spatially. First, the Line of Organic Correlation (LOC) method was used to reconstruct October–May total precipitation anomalies at each tree-ring site, as these ecotonal environments at the lower forest border are typically moisture limited. Individual site reconstructions were then combined using a hierarchical model of spatio-temporal kriging that produced annual anomaly maps on a 12 × 12 km grid during the period in common among all chronologies (1650–1976). Hydro-climatic episodes were numerically identified and modeled using their duration, magnitude, and peak. Spatial patterns were more variable during wet years than during dry years, and the evolution of drought episodes over space and time could be visualized and quantified. The most remarkable episode in the entire reconstruction was the early 1900s pluvial, followed by the late 1800s drought. The 1930s "Dust Bowl" drought was among the top ten hydroclimatic episodes in the past few centuries. These results directly address the needs of water and natural resource managers with respect to planning for "worst case" scenarios of drought duration and magnitude at the watershed level. For instance, it is possible to analyze which geographical areas are more likely to be impacted by severe and sustained droughts at annual or multiannual timescales and at spatial resolutions commonly used by regional climate models.
The Toyota Production System and art: making highly customized and creative products the Toyota way

The Toyota Production System has led to a movement of ‘lean production’ focused on taking waste out of value streams. Most applications have been to high volume, and relatively standardized products. Under this system work becomes highly standardized specifying to the second what the operator should do. Buffers are precisely sized and controlled through various types of pull signals. When possible, use of one-piece flow cells result in a completely balanced production line. The performance benefits of these lean systems are often remarkable, greatly improving quality, cost, and delivery. But what of companies that are not making standardized products at high volume? What can they learn from lean? In this paper we argue there is a fundamental misunderstanding of TPS, viewing it as a specific tool kit technically implemented in a formulaic way to achieve pre-specified results. In fact, TPS is a philosophy that can be better described as a set of general principles of organizing and managing an enterprise wh...
Properly Arranged and So Correctly Recorded

SHORTLY after Benedict Arnold's treason in the fall of 1780, an incensed Lt. Col. Richard Varick, late member of the traitor's military family, wrote to George Washington reminding him of his promise of a court of inquiry into Varick's conduct while serving under Arnold. "It is Sir, a wish," he wrote, "natural to a young man, whose rise and happiness in life depend on a fair & unblemished reputation, to preserve it inviolate . . . ' Outraged as he was by the possibility of guilt through association, Varick further requested that the court be allowed to extend its coverage to his entire military career. This Washington denied him, as it could not be done with "propriety," but when the court absolved him from the implications of corruption, he again wrote to Washington fortified by "a consciousness of the rectitude of [his] intentions" desiring distribution as wide as possible for the findings of the court. Washington must have sympathized with the young patriot, who had had a solid if not distinguished military record, serving as secretary to General Schuyler and later as Deputy Mustermaster General of the Northern Army, a position abolished by Congress in January 1780. Varick yearned to serve until the reduction of the British in New York, "if not to the close of the war," but there seemed to be no opening for him. His chance came in May of the following year, when Washington named him as his recording secretary, with the responsibility of recording his wartime papers. In early June of 1781 Varick established his office in Poughkeepsie, N. Y., at the house of Dr. Peter Tappen, Governor George Clinton's brother-in-law. The house was close to Clinton's and thus enjoyed the Governor's protection. This Varick felt was necessary
Abstract WMP64: Prehospital Triage To Comprehensive Stroke Centers: GCS Identifies Patients At Increased Risk For Death, ICH, Or SAH

INTRODUCTION: Regionalization of stroke care is occurring nationwide, but evidence-based criteria for prehospital triage to comprehensive stroke centers are lacking. We assessed the hypothesis that...
Abstract 2766: Hemodynamic Changes Following Direct EC-IC Bypass In Moyamoya Disease Patients Measured Using Combined Arterial Spin Labeling And Dynamic Susceptibility Contrast MR Imaging

Background: The goal of direct bypass in Moyamoya patients is to reduce the risk of future strokes, presumably by improving cerebral hemodynamics. Combined ASL and DSC MR perfusion imaging (CAD-perfusion) is a new quantitative methodology to measure perfusion parameters (1). Methods: We applied this method to 20 newly-diagnosed, symptomatic Moyamoya patients (11 bilateral, 9 unilateral). Imaging was acquired at 3T (GE MR 750, Waukesha, WI) before and approximately 6 months following direct STA-MCA anastomosis. ASL was performed using 3D fast-spin-echo background-suppressed pseudocontinuous ASL with the following parameters (TR/TE/label time/post-label delay 5500/2.5/1500/2000 ms; spatial resolution 3 × 3 × 4 mm; imaging time 4:37). DSC was performed using gradient-echo EPI with the following parameters (TR/TE 1800/40 ms; 1.9 × 1.9 × 5 mm; 0.1 mmol/kg Multihance contrast). Images were co-registered, placed into template space, and resliced to 10 mm axial slice thickness corresponding to the ASPECTS slices using SPM8. CAD-perfusion images (CAD-CBF and CAD-CBV) were created using standard methods (1). Analysis was by hemisphere (n=20 posterior, n=31 bypassed anterior, and n=9 non-bypassed anterior regions). Hemodynamic measurements were made in mixed cortical ROI’s. The Wilcoxon rank-sum test was used to assess significance at the p Results: 6 months following bypass, Tmax in the bypassed anterior circulation decreased significantly (from 3.6±1.2 to 3.0±0.9 sec, p=0.019) but did not change in either the non-bypassed anterior circulation or posterior circulation. CAD-CBF did not increase in any of the three regions; in particular, no increase was seen in the anterior bypassed regions (from 34.8±8.5 to 36.8±8.1 ml/100 g/min, p>0.05). This is consistent with prior reports suggesting that baseline CBF does not change following bypass (2). Interestingly, CAD-CBV was significantly increased in all regions following bypass; this change was largest in the non-bypassed anterior circulation (from 4.5±1.0 to 6.1±2.3%, p=0.035). Conclusion: Hemodynamic changes following bypass are complex and involve both hemispheres. CAD-perfusion MRI allows the ability to follow these parameters in a quantitative way.
Manet, Guéroult and Chrysippos

him unique among his Italian contemporaries of comparable or greater fame, yet he did belong with them, and perhaps even set an example for them, by virtue of his pointedly fine technique and his essays in what might be called "la maniera grande alla maniera piccolissima." To Lomazzo's saying in so a y words that Clovio raised the art of miniature to the level of the art of painting, one might add that the art of painting, in Rome and Florence of the time, often nearly equaled the art of miniature in scale or in technical quality or both (". . . si pub dire che sia di minio veramente"-the phrase would apply to a considerable number of paintings of the period). A rapprochement or even identity of Clovio's art of miniature with the art of painting was perhaps acknowledged also by El Greco, although his own paintings, large or small, could hardly be called "miniature-like" in their technique. For not only did he include Clovio's likeness among the four artists' portraits in the Minneapolis Purification of the Temple, but also, some thirty years later, when he painted a St. Luke for Toledo Cathedral,"4 he may have rendered yet another special tribute to his friend. As one may expect, the evangelist-artist is discovered here with his book and with his painting of the Madonna; but the painting is not on canvas or panel, but on one of the vellum pages of the open book. Perhaps El Greco recalled his portrait of Clovio, shown holding out the Farnese Hours for all to see, when he chose, now, as no one else to my knowledge had done,"4 to represent the patron saint of painters as a miniaturist.
Rhyolites as probes of the crust: examples from Tertiary volcanism in Arizona, southwestern U.S.A.

Geochemical and isotopic data obtained from three bimodal basalt-rhyolite fields in west-central Arizona point to significant variation in the sources of the siliceous products despite petrological similarities between them. The studied fields, which straddle the boundary between the Basin and Range and Colorado Plateau physiographic provinces, include Castaneda Hills (CH) in the Basin and Range, Kaiser Spring (KS) in the Transition Zone, and Mount Floyd (MF) in the Colorado Plateau
Prominent dysautonomia in a patient with POEMS syndrome

POEMS syndrome is a rare, multisystem disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and/or skin changes. Here we present an unusual case of a patient with POEMS syndrome who exhibited a prominent autonomic neuropathy.
Study on the Combining Ability of Red Rice Restorer Line Honghui 937

In order to promote the material innovation of hybrid rice of Guizhou Province,F1 was obtained by incomplete diallel-cross design using red rice restorer line Honghui 937,3 restorer lines and 6 male sterile line selected by Guizhou Rice Institute,and combining ability analysis of F1 were conducted for five traits(including yield,productive panicle,grains per panicle,seed setting rate and 1000-grain weight).The results showed that the expression of yield,grains per panicle,seed setting rate was better than other general combining ability(GCA)for Honghui 937,the value of them were 1.025 5,1.917 6,2.084 2 respectively.For specific combining ability(SCA),the difference were significant for the same traits in different combinations and different traits in the same combinations.Thus in the course of selection for Honghui 937 combination,it was reliable to consider the general combining ability(GCA)of male sterile line such as productive panicle,seed setting rate and 1000-grain weight,the specific combining ability(SCA) were also taken account.
Increased plasma renin substrate concentrations in human malignant hypertension.

1. In normal man, in deoxycorticosterone/salt hypertension, and in renal artery stenosis, an inverse relationship between plasma renin activity (PRA) and renin-substrate (RS) is found. 2. PRA and RS were found to be inversely related in primary aldosteronism and in anephric patients. 3. In malignant hypertension, by contrast, the highest PRA levels were associated with the highest RS levels.
Abstract 4428: Nestin suppression attenuates invasive potential of endometrial cancer cells by down regulating TGF-β signaling pathway

Nestin, an intermediate filament protein and a stem cell marker is expressed in several cancers. Little is known about the expression level and role of Nestin in endometrial cancer. Compared to immortalized endometrial epithelial cell line EM-E6/E7/TERT, endometrial cancer lines express high to moderate levels of Nestin. Endometrial tumors and tumor cell lines have a cancer stem-like cells population expressing CD133. The AN3CA and KLE cells showed more CD133+ cells and expressed Nestin at higher levels than Ishikawa cells. Knockdown of Nestin in AN3CA and KLE, and overexpression in Ishikawa cells was associated respectively with attenuation and enhancement of CD133+ cells. Knockdown of Nestin increased cells in G0/G1 phase and decreased in S phase, whereas overexpression decreased cells in G0/G1 phase and increased in S phase of cell cycle. Nestin knockdown cells showed increased expression of p21, p27 and PNCA and decreased expression of cyclin-D1 and D3. Nestin overexpression revealed an inverse expression pattern of cell cycle regulatory proteins. Nestin knockdown inhibited cancer cell growth and invasive potential by down regulating TGF-β signaling components, MMP-2, MMP-9, vimentin, SNAIL, SLUG, Twist, N-cadherin, and upregulating E-cadherin. Conversely, Nestin overexpression enhanced cell invasiveness by upregulating TGF-β signaling components, MMP-2, MMP-9, mesenchymal markers and downregulaing epithelial marker, E-cadherin. Nestin knockdown inhibited and overexpression promoted invadopodia formation and pFAK expression. Knockdown of Nestin significantly reduced tumor volume in vivo. Finally, progesterone and a nitric oxide donor inhibited Nestin expression in endometrial cancer cells. These results suggest that Nestin can be a therapeutic target for cancer treatment. Citation Format: Amber A. Bokhari, Batsukh Dorjbal, Tabari M. Baker, Sana Waheed, Christopher M. Zahn, Chad A. Hamilton, George L. Maxwell, Viqar Syed. Nestin suppression attenuates invasive potential of endometrial cancer cells by down regulating TGF-β signaling pathway. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4428.
Improving user-interface responsiveness despite performance limitations

The concept of user interface responsiveness is distinguished from that of performance. It is argued that performance limitations are inevitable and that performance need not limit responsiveness. Four techniques for improving responsiveness despite limited and/or fluctuating processing resources are presented. These are adaptive resource allocation; parallel problem solution; work-ahead, that is, precomputing solutions; X3 and nonsequential input processing. The merits and drawbacks of these techniques are discussed. >
Deferred Judgment in Foreign Policy Opinion: The Impact of Cost Procrastination on Audience Costs

The Obama administration’s 2013 policy crisis concerning intervention in the Syrian civil war features the domestic audience acting opposite our most pivotal theoretical predictions. Initial polls showed support for intervention, but the audience resisted Obama’s efforts to follow through on his threat, forcing him to change course and back down. This contradicts the audience cost proposal that citizens prefer consistency by leaders. The reversal can be explained by measurement error in early polls. I argue that survey experiments on audience preferences, which lack information on context and cost, have measurement error problems as bad as or worse than polls on opinion in real crises. I push for revamped tests that account for the types of response error studied in psychology and economics. Security scholars should try to put experimental subjects in the same frame of mind they are in when making decisions about their political opinions. I provide experimental evidence for the need to start adjusting for these measurement problems, and I propose an agenda for making inferential improvements to experimental studies of public opinion on international conflict.
Combination of Extracorporeal Shockwave Lithotripsy and Ureteroscopy for Large Staghorn Calculi in a Pediatric Patient: Case Report.

Abstract Background: Extracorporeal shockwave lithotripsy (SWL) is a procedure commonly performed to treat nephrolithiasis, with promising results in pediatric patients. However, increasing renal c...
Service Learning Within the University of Connecticut Master of Public Health Program

Despite the widely held premise that public health is “what we do collectively to assure conditions by which people can be healthy,”1 the manner by which many public health students are educated pays scant attention to the principles and strategies embodied in the concepts of “doing collectively.” Scrutiny of public health curricula often reveals disproportionate attention to conveying what is known about conditions by which people are healthy, at the expense of students experiencing what should be done to assure that necessary conditions are met. This article describes an approach to service learning at the University of Connecticut Master of Public Health (UConn MPH) Program in Farmington, Connecticut, that is designed to cultivate student interest in applied practice, contribute important and otherwise unavailable resources to the public health system, and foster enduring campus-community partnerships for health. While service learning is not a new concept in public health education, this article should serve both as a primer to those new to the concept and as a review to those already invested in service-learning activities.
Confused or not Confused?: Disentangling Brain Activity from EEG Data Using Bidirectional LSTM Recurrent Neural Networks

Brain fog, also known as confusion, is one of the main reasons of the low performance in the learning process or any kind of daily task that involves and requires thinking. Detecting confusion in human's mind in real time is a challenging and important task which can be applied to online education, driver fatigue detection and so on. In this paper, we applied Bidirectional LSTM Recurrent Neural Networks to classify students' confusions. The results show that Bidirectional LSTM model achieves the state-of-the-art performance compared with other machine learning approaches, and shows strong robustness as evaluated by cross-validation. We can predict whether or not a student is confused in the accuracy of 73.3%. Furthermore, we find the most important feature to detecting the brain confusion is gamma 1 wave of EEG signal. Our results suggest that machine learning is a potentially powerful tool to model and understand brain activities.
RAMP: resource-aware mapping for CGRAs

Coarse-grained reconfigurable array (CGRA) is a promising solution that can accelerate even non-parallel loops. Acceleration achieved through CGRAs critically depends on the goodness of mapping (of loop operations onto the PEs of CGRA), and in particular, the compiler’s ability to route the dependencies among operations. Previous works have explored several mechanisms to route data dependencies, including, routing through other PEs, registers, memory, and even re-computation. All these routing options change the graph to be mapped onto PEs (often by adding new operations), and without re-scheduling, it may be impossible to map the new graph. However, existing techniques explore these routing options inside the Place and Route (P&R) phase of the compilation process, which is performed after the scheduling step. As a result, they either may not achieve the mapping or obtain poor results. Our method RAMP, explicitly and intelligently explores the various routing options, before the scheduling step, and makes improve the mapping-ability and mapping quality. Evaluating top performance-critical loops of MiBench benchmarks over 12 architectural configurations, we find that RAMP is able to accelerate loops by 23× over sequential execution, achieving a geomean speedup of 2.13× over state-of-the-art.
Parental perceptions of participation in physical activities for preschoolers with disabilities

Children with disabilities tend to participate in fewer physical activities than typically developing children. To promote participation in physical activities for children with disabilities, it is...
A PULSE ANALYSIS SYSTEM AND COMPUTER PROGRAM FOR THE ROSSI LET COUNTER

Abstract Acceptance of the Rossi LET counter for routine health physics use depends upon the degree to which data collection and analysis can be simplified. This paper describes an electronic system for recording counter events and a computer program prepared for data analysis that contribute toward this end. In developing this system, we found that spectral stability is significantly affected by voltage and gas purity through the mechanism of varying ion collection time. Circuitry has been developed which delays sampling of the pulse height until full charge collection has been achieved. Operation as a sealed chamber has thereby been achieved over useful periods. Since the spectra realized are typically exponential in shape, extremely long data collection times are required to achieve statistical significance for the large pulses. To ameliorate this problem, an analog pulse height computer is used to compress the high energy deposition end of the spectrum according to a selectable power function before pulse height analysis is performed. The data analysis program has been made as flexible as possible to allow further studies in interpretive procedure. The raw data for both radiation field and background (where applicable) are smoothed before determining net counts. The technique used has a minimum of bias as to the spectrum shape. The smoothed spectrum is then analyzed and a probable LET spectrum determined. Since the energy loss spectrum due to mono-LET particles traversing the chamber depends on questionable assumptions, options are included for triangular, exponential, and square stripping functions. From the LET spectrum, the dose and dose equivalent are calculated, and the LET spectrum is smoothed and plotted. Examples are given of the results produced by the system for typical radiation sources.
Control of nonprehensile manipulation

Nonprehensile manipulation is the process of manipulating a part without a form- or force-closure grasp. Without such a grasp, the part is free to roll, slide, or break contact with the robot(s) manipulating it. Controlling the motion of a part using nonprehensile manipulation becomes the challenging problem of controlling a dynamic system with equations of motion incorporating the robot and part geometry, friction and restitution laws, and changing dynamics due to changing contact states. Drawing from the work of others and our own previous work, in this paper we pose several open problems in the control of nonprehensile manipulation.
The Roles of Map Kinases in Controling Cancer Metastasis

The MAP kinases have been implicated in cell growth and differentiation. Dysregulation of these pathways results in the increased incidence of tumorgenicity and metastasis. The mechanisms by which these pathways lead to cancer have yet to be elucidated. Recently, Taguchi et al. have shown that blocking the interaction of the receptor for advanced glycation end products (RAGE) and its ligand, amphoterin by various strategies, such as the administration of the soluble, extracellular region of RAGE, resulted in the reduction of tumour volume and metastases in mice (95). interestingly, the inhibition of RAGE-amphoterin interaction resulted in decreased ERK1/2, SAPK, and p38 MAP kinase activities, and reduced expression of MMP-2 and MMP-9 (95).
Structure and Function of Mitochondrial Coupling Factor B(FB)

FB is a dithiol protein which stimulates energy-driven reactions in submitochondrial particles depleted of FB by extraction with ammonia-EDTA (AE). It has been purified extensively and appears as a single band in SDS-PAGE by silver staining (Sanadi, 1982). Its instability, tendency to undergo oligomerization, and low yield have made it a difficult protein to study.
Optimistic bias about intimate partner violence among medical personnel.

BACKGROUND AND OBJECTIVES: The study seeks to contribute to the optimistic bias literature by studying the perceptual bias among medical personnel within the context of intimate partner violence (IPV). METHODS: A total of 316 medical students, residents, and nurses were surveyed. RESULTS: Care providers exhibit optimistic bias, believing they are less likely than others to become victims of intimate partner violence (IPV). Optimistic bias was related to age, third-person perception, and knowledge/expertise. CONCLUSIONS: From a screening standpoint, the finding suggests that care providers distance themselves from patients by believing they are less vulnerable to IPV, which could decrease screening or negatively impact the effectiveness of screening or the quality of patient care. This finding extends the literature, because it documents optimistic bias among medical personnel, whereas previous findings were limited to patients. Language: en
Leveraging RNA-Seq to Characterize Resistance to Brown Stem Rot and the Rbs3 Locus in Soybean

Brown stem rot, caused by the fungus Phialophora gregata, reduces soybean yield by up to 38%. Although three dominant resistance loci have been identified (Rbs1 to Rbs3), the gene networks responsible for pathogen recognition and defense remain unknown. Further, identification and characterization of resistant and susceptible germplasm remains difficult. We conducted RNA-Seq of infected and mock-infected leaf, stem, and root tissues of a resistant (PI 437970, Rbs3) and susceptible (Corsoy 79) genotype. Combining historical mapping data with genotype expression differences allowed us to identify a cluster of receptor-like proteins that are candidates for the Rbs3 resistance gene. Reads mapping to the Rbs3 locus were used to identify potential novel single-nucleotide polymorphisms within candidate genes that could improve phenotyping and breeding efficiency. Comparing responses to infection revealed little overlap in differential gene expression between genotypes or tissues. Gene networks associated with defense, DNA replication, and iron homeostasis are hallmarks of resistance to P. gregata. This novel research demonstrates the utility of combining contrasting genotypes, gene expression, and classical genetic studies to characterize complex disease resistance loci.