cssi/SciSciGPT-SciSciNet huggingface dataset:
Channel Allocation Using Pricing in Satellite Networks

We consider allocating a set of parallel channels among multiple users in a satellite network. A novel MAC protocol is proposed based on pricing that allocates network resources efficiently according to users' demand. In this paper, we first characterize the Pareto efficient throughput region in a single satellite network. The existence of a equilibrium price is presented. Furthermore, we show that such equilibrium price is unique. In the multiple satellites case, the Pareto efficient throughput region is also described. We then show that the equilibrium price exists and is unique. The resulting throughput at the equilibrium is shown to be Pareto efficient also.
Why searchers switch: understanding and predicting engine switching rationales

Search engine switching is the voluntary transition between Web search engines. Engine switching can occur for a number of reasons, including user dissatisfaction with search results, a desire for broader topic coverage or verification, user preferences, or even unintentionally. An improved understanding of switching rationales allows search providers to tailor the search experience according to the different causes. In this paper we study the reasons behind search engine switching within a session. We address the challenge of identifying switching rationales by designing and implementing client-side instrumentation to acquire in-situ feedbacks from users. Using this feedback, we investigate in detail the reasons that users switch engines within a session. We also study the relationship between implicit behavioral signals and the switching causes, and develop and evaluate models to predict the reasons for switching. In addition, we collect editorial judgments of switching rationales by third-party judges and show that we can recover switching causes a posteriori. Our findings provide valuable insights into why users switch search engines in a session and demonstrate the relationship between search behavior and switching motivations. The findings also reveal sufficient behavioral consistency to afford accurate prediction of switching rationale, which can be used to dynamically adapt the search experience and derive more accurate competitive metrics.
In Response to Snakebite Rebound Coagulopathy by Witham et al.

In the recent report of 2 cases by Witham et al, we question the identification of the snake for patient 2, who was “believed to have been bitten on the foot by a copperhead snake” before being airlifted to Fort Worth, Texas, from an outlying hospital, likely to the west of Fort Worth. Fort Worth lies at the western edge of the natural range for copperheads (Agkistrodon contortrix) but well within the natural range for western diamondback rattlesnakes (Crotalus atrox). Witham et al provide no further evidence that this was a copperhead and not a rattlesnake. Language: en
Evaluation of a long-term hindcast simulation for the Columbia River estuary

Abstract In order to simulate the biogeochemical function of estuaries across the land-ocean continuum, circulation models must represent a cascade of complex physical processes spanning several spatial and temporal scales. Furthermore, governing physical processes tend to vary under different flow regimes, in response to external forcings. Model validation must therefore cover all relevant flow regimes and span sufficiently long time to represent transient and slowly-varying phenomena. We focus in a multi-year hindcast simulation of the Columbia River estuary – a mesotidal, river-dominated estuary that is also influenced by coastal upwelling in an Eastern Boundary Current system. Model skill is assessed against long-term observational time series, covering the lower estuary (for salinity) as well as most of the tidal river (for water temperature and elevation). In addition, high-resolution profiles of velocity and salinity are used to study salt transport mechanisms at a single station. Results indicate that the model captures the estuarine dynamics of the system, but the skill depends on the flow regime: In general the model performs far better during spring tides (i.e., under partially mixed or time-dependent salt wedge regimes) than under neap tides (i.e., salt wedge and strongly stratified regimes). While the model accurately represents tidal salt transport mechanisms, it tends to underestimate gravitational transport which becomes more important under neap tide conditions. Furthermore, the skill decreases during high river discharge periods, because the model has difficulty capturing the extremely strong stratification characteristic to those periods.
Avant Garde: An American Odyssey from Gertrude Stein to Pierre Boulez by Robin Maconie

If one considers Robin Maconie's other writings, his new book, Avant Garde, contains few surprises. He has written much about Stockhausen [Other Planets: The Music of Karlheinz Stockhausen (Lanham,...
New Canadian records of Nemastoma bimaculatum (Fabricius), and a brief summary of introduced Eurasian harvestmen in North America (Arachnida, Opiliones)

Eurasian harvestmen have been introduced to, and have established themselves in North America. Species known to have been introduced include Trogulus tricarinatus (L.) 1767, Paroligolophus agrestis (Meade) 1855, Rilaena triangularis (Herbst) 1799, Oligolophus tridens (C. L. Koch) 1836, and Nemastoma bimaculatum (Fabricius) 1775, for the last of which new Canadian records (Ontario) are given below. It is not entirely determined if the species Phalangium opilio (L.) 1758, Opilio parietinus (DeGeer) 1778 and Mitopus morio (Fabricius) 1779 are introduced to North America, or are naturally of Holarctic distribution. The former seems the more likely hypothesis for the first two, but M. morio in North America may be native or may not be that species. Detailed descriptions and illustrations of all these species may be found in Martens (1978).
Hardware assisted misbehaving nodes detection in mobile ad hoc networks

The mobility feature leads to the proliferation of wireless networks. Among all kinds of wireless networks, the peer-to-peer nature of Mobile Ad hoc Networks (MANET) makes such networks very promising. Unlike traditional wired networks, MANETs do not need infrastructure to work properly. The most commonly used routing protocols for mobile ad hoc networks do not take into consideration security, assuming all the mobile nodes will coordinate with each other. Such routing protocols along with the absence of infrastructure make MANETs prone to a variety of faults such as packet dropping, packet misrouting, etc. This dissertation addresses the security issues of MANET by presenting the hardware assisted misbehaving nodes detection. In such a scheme, the hardware is responsible for detecting the misbehaving nodes. The detection results are sent to software layer of mobile nodes. Upon receiving the detection results, the software layer can exclude the misbehaving nodes from the networks. This dissertation presents two hardware detection schemes. Two-timer is a low-cost detection scheme. There are only two timers utilized in the scheme. The two-timer scheme can be used to detect simple packet dropping with good detection performance. The other detection scheme, cache scheme, can detect both packet dropping and packet misrouting. The cache scheme needs more resource than the two-timer scheme along with better detection performance.
Abstract 1105: Dysregulated ΔNp63α displaces p73 from the promoter of the tumor suppressor gene maspin in keratinocytes

The p53 homologue p63 is critical for normal epidermal development. While overexpression of p63, in particular ΔNp63α, has been reported in many squamous cell cancers including those of the skin, the role of p63 in cancer pathogenesis remains unclear. We have previously shown that elevated levels of ΔNp63α aberrantly maintain keratinocyte proliferation under differentiating conditions. We performed microarray analyses of primary murine epidermal keratinocytes overexpressing adenoviral (Ad)-driven ΔNp63α vs. β-gal to identify target genes impacted by dysregulated ΔNp63α. Our studies revealed a coordinated downregulation of RNA transcripts for multiple protease inhibitors, including two members of the serine protease inhibitor (serpin) family, maspin (serpinB5) and plasminogen activator inhibitor-2, PAI-2 (serpinB2), in addition to the metalloproteinase inhibitor, tissue inhibitor of metalloproteinase-3 (TIMP-3). Downregulation of all three protease inhibitors was confirmed by RT-PCR and examined further by western analysis. TIMP-3 protein was detected in keratinocyte conditioned medium but not in whole cell lysates, supporting a primarily extracellular function for TIMP-3. PAI-2 and maspin were detected in both whole cell lysates and conditioned medium, consistent with both intracellular and extracellular roles for these proteins. Secreted levels of TIMP-3 and PAI-2 declined in Ad-ΔNp63α-cultures compared to Ad-β-gal-cultures, whereas maspin levels remained stable. Intracellular expression of both PAI-2 and maspin was negatively regulated by ΔNp63α. To investigate the mechanism by which ΔNp63α down-regulates maspin, we performed electrophoretic mobility shift assays (EMSAs) using a known p53 consensus DNA binding sequence in the maspin promoter. An endogenous complex was seen by EMSA in normal keratinocytes that was disrupted in the presence of increasing levels of ΔNp63α. Supershift analysis revealed that this endogenous complex was interrupted by the addition of a p73 antibody, but no supershift or block was seen with antibodies to p63 or p53. EMSA analysis of nuclear extracts prepared from p73(-/-) keratinocytes confirmed that p73 is required for this complex formation. The current data suggest additional roles for ΔNp63α in cancer pathogenesis by disrupting p73 transcriptional activity to down-modulate protease inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1105.
The Morphology of Lagenidium Callinectes II. Zoosporogenesis

Zoosporogenesis in the holocarpic marine phycomycete Lagenidium callinectes is initiated when actively growing mycelium is washed free of medium and placed in sea water. Portions of hyphae are wall...
Prosthetic and sensory aids reference exhibit. The search that never ends.

As part of the Veterans Administration Prosthetic and Sensory Aids Reference exhibit, the Research Section shows how the program, through contracts and the VA's own facilities, aims to initiate and...
Standard Design and Application of Substation Monitoring System

For reason of lacking unified standard requirements,the monitoring system software and hardware of substation are uneven which may cause great inconvenience to utilization and maintenance for the system.Therefore,this paper introduces a standardized and normalized design scheme for substation monitoring system.Combining specific application,it analyzes and summarizes the design scheme.It points out that the design scheme and application experiences are feasible to provide technical support for power grid monitoring system,ensure operational and maintenance safety in aspects of design and technology and provide experience in reference for other standardized work.
Use of extracorporeal membrane oxygenators in persistent pulmonary hypertension of the newborn

The author describes the rational use of cardiotonic agents in those infants with PPHN in whom myocardial dysfunction and/or extremely abnormal systemic vascular resistance have been completely documented.
Henry Crabb Robinson (1775–1867)

Though remembered today as a great diarist, a man who kept copiously detailed records of how he mediated, with skill and tact, between warring parties, Henry Crabb Robinson contributed generously to the developing careers of major literary and political figures for a full seven decades. He helped Mme. de Stael understand better the writings of German philosophers; served as foreign editor of The Times, and wrote accurate, useful despatches from Spain during the Peninsular War; was a founding father of both the Athenaeum Club and University College, London; and assisted biographers of Goethe and Blake, among others, by contributing invaluable personal information. He was a good friend of Lamb, Coleridge, Southey, and any number of writers who, he believed, contributed to the cultural improvement of what, for want of a better phrase, may be called the English sense of good taste.
A Nationwide Assessment of the Association of Smoking Bans and Cigarette Taxes with Hospitalizations for Acute Myocardial Infarction, Heart Failure, and Pneumonia

Multiple studies claim that public place smoking bans are associated with reductions in smoking-related hospitalization rates. No national study using complete hospitalization counts by area that accounts for contemporaneous controls including state cigarette taxes has been conducted. We examine the association between county-level smoking-related hospitalization rates and comprehensive smoking bans in 28 states from 2001 to 2008. Differences-in-differences analysis measures changes in hospitalization rates before versus after introducing bans in bars, restaurants, and workplaces, controlling for cigarette taxes, adjusting for local health and provider characteristics. Smoking bans were not associated with acute myocardial infarction or heart failure hospitalizations, but lowered pneumonia hospitalization rates for persons ages 60 to 74 years. Higher cigarette taxes were associated with lower heart failure hospitalizations for all ages and fewer pneumonia hospitalizations for adults aged 60 to 74. Previous studies may have overestimated the relation between smoking bans and hospitalizations and underestimated the effects of cigarette taxes.
Scripted fantasies and innovative Orientalisms: media, youth, and ideology in the age of the "war on terror"

Anxieties associated with global conflict surround youth and ideological narratives mediating these conflicts can be seen in the popular media youth consume. This investigation uses contemporary cu...
Active subjects of passive monitoring: responses to a passive monitoring system in low-income independent living

Passive monitoring technology is beginning to be reimbursed by third-party payers in the United States of America. Given the low voluntary uptake of these technologies on the market, it is important to understand the concerns and perspectives of users, former users and non-users. In this paper, the range of ways older adults relate to passive monitoring in low-income independent-living residences is presented. This includes experiences of adoption, non-adoption, discontinuation and creative 'misuse'. The analysis of interviews reveals three key insights. First, assumptions built into the technology about how older adults live present a problem for many users who experience unwanted disruptions and threats to their behavioural autonomy. Second, resident response is varied and challenges the dominant image of residents as passive subjects of a passive monitoring system. Third, the priorities of older adults (e.g. safety, autonomy, privacy, control, contact) are more diverse and multi-faceted than those of the housing organisation staff and family members (e.g. safety, efficiency) who drive the passive monitoring intervention. The tension between needs, desires and the daily lives of older adults and the technological solutions offered to them is made visible by their active responses, including resistance to them. This exposes the active and meaningful qualities of older adults' decisions and practices.
Ultrafast electron microscopy: Instrument response from the single-electron to high bunch-charge regimes

Abstract We determine the instrument response of an ultrafast electron microscope equipped with a conventional thermionic electron gun and absent modifications beyond the optical ports. Using flat, graphite-encircled LaB 6 cathodes, we image space-charge effects as a function of photoelectron-packet population and find that an applied Wehnelt bias has a negligible effect on the threshold levels (>10 3 electrons per pulse) but does appear to suppress blurring at the upper limits (∼10 5 electrons). Using plasma lensing, we determine the instrument-response time for 700-fs laser pulses and find that single-electron packets are laser limited (1 ps), while broadening occurs well below the space-charge limit.
Emerging Issues in the Social Psychology of Justice

An increasing number of public policy issues arise in the context of competing claims about whatprocesses constitute fair ways of making allocation decisions and whatpatterns represent fair distributions of resources and benefits. Aslaissez faire capitalism has given way to the managed economy, a growing level of controversy about how the economy is to be both fairly and efficiently managed has developed. Although competing interests have always existed, the intensity of conflict has been heightened by expanded claims of entitlement based on increasing demands for the recognition of certain rights. In short, more and more areas subject to legislative, executive, and judicial discretion are framed in terms of questions about justice. Divergent perceptions of what is fair are both a common occurrence and a threat to the tractability of public policy decisions
Global Impact of the CFC Phaseout

The amendments to the Montreal Protocol and the 1990 Clean Air Act call for the accelerated reduction of fully halogenated CFCs and halons. Recent scientific data indicate that these chemicals are more damaging to the earth's ozone layer than previously thought. This ozone depletion has serious consequences for the environment and human health. These chemical compounds are scheduled for phaseout under the Montreal Protocol and Clean Air Act. Because CFC-13 and methyl chloroform are used extensively in the electronics industry worldwide, the industry and the U.S. EPA have formed a partnership to develop technically feasible, cost-effective, and environmentally sound alternatives for ozone-depleting substances.
Phase I study of panobinostat (LBH589) and letrozole in post-menopausal women with metastatic breast cancer.

e13501 Background: Loss of estrogen receptor alpha gene expression has been associated with insensitivity to endocrine therapy in human breast cancer patients. Histone deacetylase (HDAC) inhibitors...
Multiscale and Multiresolution methods for Sparse representation of Large datasets

Abstract In this paper, we have presented a strategy for studying a large observational dataset at different resolutions to obtain a sparse representation in a computationally efficient manner. Such representations are crucial for many applications from modeling and inference to visualization. Resolution here stems from the variation of the correlation strength among the different observation instances. The motivation behind the approach is to make a large dataset as small as possible by removing all the redundant information so that, the original data can be reconstructed with minimal losses of information.Our past work borrowed ideas from multilevel simulations to extract a sparse representaiton. Here, we introduce the use of multi-resolution kernels. We have tested our approach on a carefully designed suite of analytical functions along with gravity and altimetry time series datasets from a section of the Greenland Icesheet. In addition to providing a good strategy for data compression, the proposed approach also finds application in efficient sampling procedures and error filtering in the datasets. The results, presented in the article clearly establish the promising nature of the approach along with prospects of its application in different fields of data analytics in the scientific computing and related domains.
On prosodic variation and the distribution of wh- in-situ

Wh- in-situ is a pervasive feature of Tano interrogative syntax, yet the Tano languages differ from one another in subtle ways with respect to the distribution of in-situ interrogatives. Languages like Krachi and Bono allow wh- in-situ in both main and embedded complement clauses, whereas closely related languages like Wasa and Asante Twi only allow wh- in-situ in main clauses. In this article, I argue that the generalization underpinning this variation in Tano concerns a prohibition on wh- items phrasing with C0 at the level of Intonational Phrase (ιP). I show that the ability of a wh- item to appear in-situ correlates with the prosodic status of its immediately containing clause. Embedded complement clauses are parsed as independent ιP units in Krachi and Bono, but not in Wasa and Asante Twi. Thus, ιP boundaries divide C0 from embedded interrogatives in Krachi and Bono, preventing the items from forming a prosodic constituent at the level of ιP. Conversely, no such boundaries intervene between embedded C0 and wh- in Wasa and Asante Twi, yielding prosodic mappings in which the items phrase together. Consequently, embedded wh- in-situ is prosodically licit in Krachi and Bono, but not in Wasa and Asante Twi. In this way, the Tano pattern of wh- in-situ variation described above reduces to a difference in how syntactic structures are externalized via prosodic mapping.
Alcoholism and co-morbid psychiatric disorders among American Indians.

Much of the data reported here regarding American Indian (AI) people has originated from specific areas with particular peoples. Thus, one must be cautious in applying information from one tribe to the hundreds of tribes living across the United States. As with any people, psychiatric disorder may be a pre-existing rationale for using alcohol. Or alternatively, alcohol may lead to various psychiatric disorders, such as organic mental conditions, posttraumatic stress disorder, or other conditions. A third alternative is that both alcoholism and other psychiatric disorder merely happen to affect the same person by chance. Recognizing alcoholism and treating it in a timely manner before disabling or even permanent psychiatric disorders ensue are key strategies. In addition, clinicians must be able to recognize and then either treat or refer co-morbid patients for appropriate care. Some psychiatric disorders, such as panic disorder, posttraumatic stress disorder, and various organic mental disorders may occur more often in some AI groups. Other co-morbid conditions, such as eating disorders, may occur less often among AI patients with alcoholism. It could be argued that resources should go solely to preventive efforts, thereby negating the need for psychiatric services. However, successful prevention of alcoholism may hinge upon, and increase the need for greater psychiatric services in AI communities. Language: en
The River Basin Concept as seen from a Management Perspective in USA

In the USA interest in river basins as units for water planning began in the late 19th century as technological progress in engineering provided data for such broader approaches. The emphasis on integrated, comprehensive river basin planning peaked in the 1930s and 1940s as epitomized by the Tennessee Valley Authority experience and New Deal emphasis on rational decision making. Well into the 1950s efforts to intertwine the water concepts of river basin development with regional economic and social planning continued to receive support. But for various reasons in the 1960s till today river basin development and regional planning have pulled apart, river basin management being limited largely to hydrological aspects of river systems engineering. Regional planning and development, in turn, has ceased to focus on the river basin, becoming primarily concerned with inter-related urban socioeconomic and political factors and forces with some attention to environmental values and constraints. Thus regions have become foci for urban socio-economic and political analyses, and river basins continue as significant hydrological planning units for efficient control of water resources.
A PRELIMINARY, EXPERIMENTAL, ENERGY PERFORMANCE ASSESSMENT OF FIVE HOUSES IN THE MHFA EARTH-SHELTERED HOUSING DEMONSTRATION PROGRAM

ABSTRACT Net electrical energy consumptions, component load distributions and heating efficiency comparisons are presented for five earth-sheltered houses located in Minnesota for the period of June 1980 to February 1981. The energy performance of two of the houses is detailed for a set of two contrasting ambient weather conditions. The results presented enable an assessment of the earth-sheltered housing concept to be made and demonstrate the effectivness of the ‘Total Gaseous Internal Energy’ as a quantitative earth-sheltered housing comparative indicator.
We’re Off to See the Wizard: In Search of Cultural Sustainability

Beginning with the remarkable success of the musical Wicked, this chapter poses our central question: How has Oz managed to sustain itself for over a century? The chapter then provides an overview of the multi-disciplinary framework through which we seek to answer this question and thus build toward an expanded theory of cultural sustainability. We consider Oz’s narrative vitality through the lenses of adaptation theory, fanfiction studies, and discussions of convergence culture and remediation, and its commercial vitality as framed by macromarketing, Consumer Culture Theory, and experiential marketing. We end by explaining how our work contributes to larger discussions about Oz and in Consumer Culture Theory.
A Machine Learning Assisted Cell Selection Method for Drones in Cellular Networks

We apply machine learning techniques to predict the cell quality for the aerial drones connecting with a standard cellular network on the ground. Stationary and strong spatial correlation of the aerial channels allow for exploiting predictive techniques for optimal cell selection based on few available neighboring observations. Yet, drastic cell quality changes due to the side lobes of base-station antenna patterns require advanced solutions for accurate prediction. In this paper, we propose a conditional random field based framework to predict a drone's best (or top few) candidates for the serving cell. Our results, assuming realistic antenna patterns as well as errors in the location estimates, show a high prediction accuracy, thereby illustrating the feasibility of exploiting learning approaches to predict the aerial channel environment.
Modeling arsenic (V) removal from water by micellar enhanced ultrafiltration in the presence of competing anions.

Abstract With increasing arsenic (As) contamination incidents reported around the world, better processes for As removal from industrial wastewater and other contaminated waters are required to protect drinking water sources. Complexation of As with cetylpyridinium chloride (CPC) cationic surfactant micelles, coupled with ultrafiltration (UF), has the potential to improve As removal, but competition from other anions could be a limiting factor. Using a binary-system ion-exchange model, the selectivity coefficients for binding of the monovalent and divalent forms of arsenate (As (V)) to cationic cetylpyridinium (CP+) micelles, relative to Cl−, were determined to be 0.55 for H2AsO4− and 0.047 mol L−1 for HAsO42−, respectively. The affinity sequence for binding of commonly occurring monovalent anions by CP+ micelles was found to be NO3− > Cl− > HCO3− > H2AsO4−, and for divalent anions, SO42− > HAsO42−. Distribution of As (V) between the micellar and aqueous phases was explored using ion exchange isotherms, with higher pH and lower concentrations of competing anions increasing rejection of As (V) across UF membranes. A model accounting for these effects, based on mass balances across UF membranes and selectivity coefficients for binding of anions to the CP+ micelles, was used to predict As (V) removal during micellar-enhanced ultrafiltration (MEUF) of mixtures of competing anions. Model predictions agreed well with experiment results for both artificial and spiked natural river water samples. Arsenic (≈0.1 mM) removals of 91% and 84% were achieved from artificial waters and spiked natural river waters, respectively, by adding 20 mM CPC prior to UF.
Vaginal Laceration During Barium Enema With Extraperitoneal Extravasation: Case Report and Literature Review

Unrecognized vaginal intubation during the barium enema procedure with subsequent balloon inflation and contrast instillation is a potentially fatal complication of an otherwise common and routine procedure. We describe a patient who, while undergoing a routine barium enema, had misplacement of the enema catheter into the vagina, subsequent rupture of the superior/lateral vagina upon inflation of the catheter retention balloon, and injection of barium contrast into the retroperitoneum. The patient was admitted for surgical repair of the vaginal laceration and monitoring for chemical peritonitis; and was managed without exploratory laparotomy. We review the existing literature, summarize 18 reported cases from worldwide literature, detail potential complications and propose management and prevention strategies based on the mechanism of injury.
937-P: Self-Reported Acute Psychological Stress Is Associated with CGM-Based Hyperglycemia in Type 1 Diabetes

Objective: There have been no clear data describing the association between acute psychological stress and glycemic variability (GV) in people with type 1 diabetes (T1D). Patients self-report that acute stress leads to hyperglycemia. Methods: Twenty adults with T1D on CGM augmented insulin pump completed self-reported psychological stress diaries for a period of 5 weeks at 2 clinical research centers. Participants reported intensity of stress on a 7-point scale, with 1 indicating mild stress and 7 severe stress, and duration of each stress episode. CGM data were analyzed for week 1 and week 5. Results: Baseline characteristics were age 44.9±15.0 years, F/M 12/8, HbA1c 6.8±0.7%, and diabetes duration 22.9±15.9 years. Total number of stress events reported was 126 over the two-week period. Subjects reported stress on average of 9±2.2 days representing 64.2%±28.2% of days. GV was compared on days of stress vs. days without stress for each subject. Mean BG did not differ; however, % time spent above 250 mg/dl was less in patients who did not report stress events during the day (6.1± 9.8%) compared to patients with stressful episodes (10.1±17.6%) (p=0.02) (Table). Discussion: Acute stress in patients with T1D was associated with certain measures of GV. We are currently analyzing GV based on duration and intensity of stress and the time between reported stress and change in glucose. Disclosure V. Dadlani: None. J.E. Pinsker: Research Support; Self; Ascensia Diabetes Care, Dexcom, Inc., Insulet Corporation, LifeScan, Inc., Roche Diabetes Care, Tandem Diabetes Care. Speaker9s Bureau; Self; Tandem Diabetes Care. K. Kumari: None. C.C. Andre: None. M. Cescon: None. C. Reid: None. S.K. McCrady-Spitzer: None. P. Thapa: None. M. Church: None. D. Choudhary: None. F.J. Doyle: Consultant; Self; ModeAGC. Other Relationship; Self; Insulet Corporation. E. Dassau: Consultant; Self; Eli Lilly and Company, Insulet Corporation. Research Support; Self; Dexcom, Inc., DreaMed Diabetes, Ltd., Insulet Corporation, Roche Diabetes Care, Tandem Diabetes Care, Xeris Pharmaceuticals, Inc. Speaker9s Bureau; Self; Roche Diabetes Care. Other Relationship; Self; ModAGC. Y.C. Kudva: Advisory Panel; Self; Novo Nordisk Inc. Other Relationship; Self; Dexcom, Inc., Roche Diabetes Care, Tandem Diabetes Care. Funding JDRF; The Leona M. and Harry B. Helmsley Charitable Trust (2-SRA-2017-503-M-B); Dexcom, Inc. (IIS-2017-043)
Analyzing Rhabdomyosarcoma using the Multimodal Clustering Approach (DReiM)

Rhabdomyosarcoma is a type of cancer that is connected to soft tissue, connective tissue, or bone. Every year 350 children are diagnosed with Rhabdomyosarcoma. Majority of the kids diagnosed with this disease are under ten years of age. Though the intensive conventional approach to treatment exists, patients are still at high risks to this aggressive disease. The need to gain understanding and insight into this disease can help the design of therapeutic agents. We utilized a multimodal network approach to gain an understanding of this mechanism. Protein phosphorylation has been mostly studied as a post-translational modification in eukaryotes. They play a significant role in various cellular processes. The mechanism of its oncogenes is not well known with various levels of signaling protein dysregulation. In the Phosphosite database, some proteins phosphorylate to cause Rhabdomyosarcoma. Our method utilizes a co-clustering approach using multimodal networks to analyze the rhabdomyosarcoma network. Rhabdomyosarcoma network in general consists of several heterogeneous networks that include gene-pathway, pathway-drug, and gene-drug. We reconstruct the phosphorylation network for Rhabdomyosarcoma, by creating a network that consists of different types of nodes. The goal is to implement this clustering approach to identify a potential candidate for Rhabdomyosarcoma. We applied network centrality measures to find the most influential nodes first and foremost and then used the clustering approach stated above towards drug repositioning.
Determination of the major tautomeric form of the covalently modified adenine in the (+)-CC-1065-DNA adduct by 1H and 15N NMR studies.

({plus})-CC-1065 is an extremely potent antitumor antibiotic produced by Streptomyces zelensis. The potent cytotoxic effects of the drug are thought to be due to the formation of a covalent adduct with DNA through N3 of adenine. Although the covalent linkage sites between ({plus})-CC-1065 and DNA have been determined, the tautomeric form of the covalently modified adenine in the ({plus})-CC-1065-DNA duplex adduct was not defined. The (6-{sup 15}N)deoxyadenosine-labeled 12-mer duplex adduct was then studied by {sup 1}H and {sup 15}N NMR. One-dimensional NOE difference and two-dimensional NOESY {sup 1}H NMR experiments on the nonisotopically labeled 12-mer duplex adduct demonstrate that the 6-amino protons of the covalently modified adenine exhibit two signals at 9.19 and 9.08 ppm. Proton NMR experiments on the (6-{sup 15}N)deoxyadenosine-labeled 12-mer duplex adduct show that the two resonance signals for adenine H6 observed on the nonisotopically labeled duplex adduct were split into doublets by the {sup 15}N nucleus with coupling constants of 91.3 Hz for non-hydrogen-bonded and 86.8 Hz for hydrogen-bonded amino protons. The authors conclude that the covalently modified adenine N6 of the ({plus})-CC-1065-12-mer duplex adduct is predominantly in the doubly protonated form, in which calculations predict that the C6-N6 bond is shortened and the positive chargemore » is delocalized over the entire adenine molecule.« less
2363 Laparoscopic Management of Heterotopic Cornual Pregnancy - Tips & Tricks

Video Objective To provide practical tips and tricks on laparoscopic management of a heterotopic cornual pregnancy. Setting This video presents a 38-year-old nulliparous female patient who received bilateral salpingectomy and then underwent in vitro fertilization. Heterotopic pregnancy was found at 8 weeks of gestation. We arranged fetal reduction by ultrasound-guided potassium chloride injection. Two weeks after the procedure, severe lower abdominal pain developed. Due to massive hemoperitoneum with suspected left cornual rupture, she was admitted for laparoscopic intervention. Interventions Laparoscopic surgery was arranged. Left cornual pregnancy with necrosis and oozing were seen upon entry into the abdominal cavity. Estimated internal bleeding was about 3000 ml. Laparoscopic management was carried out in five steps: identification of the cornual protruding mass; control of bleeding via a loop ligation; incision of the cornus precisely with complete removal of the ectopic gestational tissue; closure of the defect of the cornus; and hemostasis using Floseal matrix. Conclusion The surgery was done smoothly and the patient recovered well with ongoing pregnancy. However, the patient underwent termination of pregnancy at 23 weeks of gestation due to fetal hydrocephalus.
Interdisciplinary Care and Communication in the Intensive Care Unit

Optimal patient care in the intensive care unit (ICU) begins with an interdisciplinary approach supported with effective communication. In the fast-paced and high stress ICU environment, efficient interdisciplinary teamwork is critical. Teamwork and communication across disciplines improves patient outcomes, as well as staff and family satisfaction.
The Quest for Data Transparency

Past and recent cases of data misuses and data breaches, and the central role that data plays today for artificial intelligence (AI) systems, are pushing the notion of data transparency at the forefront in several contexts. However, data transparency is still patchy and does not even have a comprehensive definition; rather, there are different definitions.
What is gun culture? Cultural variations and trends across the United States

We developed empirical methods to identify variations in elements of gun culture across states. Using these methods, we then analyzed the prominence of these subcultures between states and over time from 1998 through 2016. Using state-level data, we conducted a principal component analysis of 11 variables associated with gun-related behaviors and retained only the significant components. We then analyzed the presence of these components over time and across states. Based on the principal component analysis, we identified three cultural variations. Component 1 reflected recreational elements of gun culture. Component 2 represented a self-defense element of gun culture. Component 3 was indicative of a symbolic cultural element centered around the protection of the Second Amendment and insurrectionism. Over time, the recreational cultural element declined in prominence while the self-defense one rose and the Second Amendment advocacy one remained stable. This paper advances the literature on gun culture by demonstrating that: (1) gun culture is not monolithic; (2) there are multiple elements of gun culture that vary substantially between states; (3) over time, the recreational gun subculture has been falling in prominence whereas the self-defense subculture has been rising; and (4) there is another subculture, distinct from the self-defense one, which consists in mobilization around the Second Amendment and was strongest in places where state firearm laws are most extensive.
Biphasic Squamoid Alveolar Renal Cell Carcinoma of the Kidney Involved by Atypical CD5-Positive B-Cells.

Biphasic squamoid alveolar renal cell carcinoma (BSARCC) is a recently described kidney cancer entity with <60 published cases so far. Some unique features of BSARCC include distinct squamoid and a...
Phase of firing coding of learning variables across the fronto-striatal network during feature-based learning

The prefrontal cortex and striatum form a recurrent network whose spiking activity encodes multiple types of learning-relevant information. This spike-encoded information is evident in average firing rates, but finer temporal coding might allow multiplexing and enhanced readout across the connected network. We tested this hypothesis in the fronto-striatal network of nonhuman primates during reversal learning of feature values. We found that populations of neurons encoding choice outcomes, outcome prediction errors, and outcome history in their firing rates also carry significant information in their phase-of-firing at a 10–25 Hz band-limited beta frequency at which they synchronize across lateral prefrontal cortex, anterior cingulate cortex and anterior striatum when outcomes were processed. The phase-of-firing code exceeds information that can be obtained from firing rates alone and is evident for inter-areal connections between anterior cingulate cortex, lateral prefrontal cortex and anterior striatum. For the majority of connections, the phase-of-firing information gain is maximal at phases of the beta cycle that were offset from the preferred spiking phase of neurons. Taken together, these findings document enhanced information of three important learning variables at specific phases of firing in the beta cycle at an inter-areally shared beta oscillation frequency during goal-directed behavior. The average spiking frequency in the fronto-striatal network encodes multiple types of learning-relevant information. Here, the authors show that populations of neurons in non-human primates also carry significant information in their phase-of-firing when learning-relevant outcomes are processed.
Integration of deep learning and soft robotics for a biomimetic approach to nonlinear sensing

Traditional approaches to sensing have often been aimed at simple sensor characteristics to make interpretation of the sensor outputs easier, but this has also limited the quality of the encoded sensory information. Integrating a complex sensor with deep learning could hence be a strategy for removing current limitations on the information that sensory inputs can carry. Here, we demonstrate this concept with a soft-robotic sensor that mimics fast non-rigid deformation of the ears in certain bat species. We show that a deep convolutional neural network can use the nonlinear Doppler shift signatures generated by these motions to estimate the direction of a sound source with an estimation error of ~0.5°. Previously, determining the direction of a sound source based on pressure receivers required either multiple frequencies or multiple receivers. Our current results demonstrate a third approach that makes do with only a single frequency and a single receiver. Bats with sophisticated biosonar systems move their ears at a high speed to help localize sound sources. Yin and Muller present a system inspired by this strategy, which can localize sounds with high accuracy and with a single detector, using a flexible silicone model of a bat’s ear and a deep convolutional neural network to process the complex Doppler signatures.
DNA polymerase λ promotes error-free replication through Watson–Crick impairing N1-methyl-deoxyadenosine adduct in conjunction with DNA polymerase ζ

Abstract In a previous study we showed that replication through the N1-methyl-deoxyadenosine (1-MeA) adduct in human cells is mediated via three different Polι/Polθ, Polη, and Polζ dependent pathways. Based on biochemical studies with these Pols, in the Polι/Polθ pathway, we inferred a role for Polι in the insertion of a nucleotide (nt) opposite 1-MeA and of Polθ in extension of synthesis from the inserted nt; in the Polη pathway, we inferred that this Pol alone would replicate through 1-MeA; in the Polζ pathway, however, the Pol required for inserting a nt opposite 1-MeA had remained unidentified. In this study, we provide biochemical and genetic evidence for a role for Polλ in inserting the correct nt T opposite 1-MeA, from which Polζ would extend synthesis. The high proficiency of purified Polλ for inserting a T opposite 1-MeA implicates a role for Polλ - which normally uses W-C base pairing for DNA synthesis – in accommodating 1-MeA in a syn confirmation and forming a Hoogsteen base pair with T. The potential of Polλ to replicate through DNA lesions by Hoogsteen base pairing adds another novel aspect to Polλ's role in translesion synthesis in addition to its role as a scaffolding component of Polζ. We discuss how the action mechanisms of Polλ and Polζ could be restrained to inserting a T opposite 1-MeA and extending synthesis thereafter, respectively.
a 3d Point Cloud Deep Learning Approach Using LIDAR to Identify Ancient Maya Archaeological Sites

Abstract. Airborne light detection and ranging (LIDAR) systems allow archaeologists to capture 3D data of anthropogenic landscapes with a level of precision that permits the identification of archaeological sites in difficult to reach and inaccessible regions. These benefits have come with a deluge of LIDAR data that requires significant and costly manual labor to interpret and analyze. In order to address this challenge, researchers have explored the use of state-of-the-art automated object recognition algorithms from the field of deep learning with success. This previous research, however, has been limited to the exploration of deep learning processes that work with only 2D data, which excludes the use of available 3D data. Our research addresses this gap and contributes knowledge on the use of deep learning-based processes that can classify archaeological sites from LIDAR generated 3D point cloud datasets. LIDAR data from the UNESCO World Heritage Site of Copan, Honduras is used as the primary dataset to compare the classification accuracy of deep learning models using 2D and 3D data. The results demonstrate that models using 3D point cloud datasets provide the greatest classification accuracy in identifying Maya archaeological sites while requiring less data preparation. Further, the research contributes knowledge on the efficacy of data augmentation strategies when working with small 3D datasets.
Positive Dynamic Partial Effects of Head Start for Jointly Dependent Good and Bad Outcomes

We adopt a framework to specify a household's child development technology with a set of interdependent inputs and outputs, finding significant, productive dynamic effects due to young children's Head Start participation. Our panel data estimates show that initial counter-productive partial effects from Head Start relative to non-Head Start participation are quickly overcome as the child matures so that this program causes significant improvements in math and reading scores as well as a significant reduction of behavioral problems over time. Measures of technical efficiency and productivity change over time for children with Head Start are highly consistent with these trends.