cssi/SciSciGPT-SciSciNet huggingface dataset:
Payoff to ISO 9000 Registration

This study examines the linkage between attaining ISO 9000 registration and stock performance. Our empirical findings suggest that investing in ISO 9000 companies can result in significant gains as compared to a similar investment in the S&P 500 index. For example, an initial investment of $100,000 in ISO 9000 companies at the beginning of February 1990 would have grown to $814,335 by January 2000. A similar investment in the S&P 500 market index would have grown to $423,745. Over different holding periods the ISO 9000 portfolio still outperforms the S&P 500, and in many cases at a lower level of risk relative to the S&P 500 market index.
Effects of nutrients and dissolved organic matter on the response of phytoplankton to ultraviolet radiation: experimental comparison in spring versus summer

The effects of nutrients and dissolved organic matter (DOM) on the response of phytoplankton community structure to ultraviolet radiation (UVR) was studied using natural phytoplankton assemblages from Lake Giles (Northeastern Pennsylvania), a temperate, oligotrophic, highly UVR-transparent lake. Microcosm experiments were conducted in 1-l bags in the spring and summer. A factorial design was used, with two UVR treatments (ambient and reduced), two nutrient treatments (control with no nutrients added, and nitrogen and phosphorus addition together), and two DOM treatments (control of 1 mg l−1 and doubled). In April, UVR affected the overall phytoplankton community structure, causing a shift in the dominant species. Significant interactive effects of UVR × nutrients and UVR × DOM were found on total phytoplankton biovolumes. In July, all taxa responded positively to the N + P addition, and were affected differentially by the UVR treatments. The initial communities varied in April and July, but Synura sp. and Chroomonas sp. were present in both seasons. Synura sp. responded positively to the addition of DOM in April and the reduction of UVR in July. Chroomonas sp. responded positively to the reduction of UVR in April and the addition of nutrients in July. The differential sensitivity of these two species suggests that changing environmental factors between spring and summer promoted differences in the relative importance of UVR in changing phytoplankton community structure.
The biology of melanocyte and melanocyte stem cell

The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations. The stem cells are regulated by communication with their specialized microenvironment known as the niche. Despite remarkable progress in understanding stem cell-intrinsic behavior, the molecular nature of the extrinsic factors provided to the stem cells by the niche microenvironment remains poorly understood. In this regard, the bulge niche of the mammalian hair follicle offers an excellent model for study. It holds two resident populations of SCs: epidermal stem cells and melanocyte stem cells. While their behavior is tightly coordinated, very little of the crosstalk involved is known. This review summarized the recent development in trying to understand the regulation of melanocyte and melanocyte stem cells. A better understanding of the normal regulation and behaviors of the melanocytes and the melanocyte stem cells will help to improve the clinical applications in regenerative medicine, cancer therapy, and aging.
Safety and Health in Biomass Production, Transportation, and Storage: A Commentary Based on the Biomass and Biofuels Session at the 2013 North American Agricultural Safety Summit

There is significant interest in biomass production ranging from government agencies to the private sector, both inside and outside of the traditional production agricultural setting. This interest has led to an increase in the development and production of biomass crops. Much of this effort has focused on specific segments of the process, and more specifically on the mechanics of these individual segments. From a review of scientific literature, it is seen that little effort has been put into identifying, classifying and preventing safety hazards in on-farm biomass production systems. This commentary describes the current status of the knowledge pertaining to health and safety factors of biomass production and storage in the US and identifies areas of standards development that the biomass industry needs from the agricultural safety and health community.
Tobacco Cessation May Improve Lung Cancer Patient Survival

Introduction: This study characterizes tobacco cessation patterns and the association of cessation with survival among lung cancer patients at Roswell Park Cancer Institute: an NCI Designated Comprehensive Cancer Center. Methods: Lung cancer patients presenting at this institution were screened with a standardized tobacco assessment, and those who had used tobacco within the past 30 days were automatically referred to a telephone-based cessation service. Demographic, clinical information, and self-reported tobacco use at last contact were obtained via electronic medical records and the Roswell Park Cancer Institute tumor registry for all lung cancer patients referred to the service between October 2010 and October 2012. Descriptive statistics and Cox proportional hazards models were used to assess whether tobacco cessation and other factors were associated with lung cancer survival through May 2014. Results: Calls were attempted to 313 of 388 lung cancer patients referred to the cessation service. Eighty percent of patients (250 of 313) were successfully contacted and participated in at least one telephone-based cessation call; 40.8% (102 of 250) of persons contacted reported having quit at the last contact. After controlling for age, pack year history, sex, Eastern Cooperative Oncology Group performance status, time between diagnosis and last contact, tumor histology, and clinical stage, a statistically significant increase in survival was associated with quitting compared with continued tobacco use at last contact (HR = 1.79; 95% confidence interval: 1.14–2.82) with a median 9 month improvement in overall survival. Conclusions: Tobacco cessation among lung cancer patients after diagnosis may increase overall survival.
Trends in meat consumption in the USA

OBJECTIVE To characterize the trends, distribution, potential determinants, and public health implications of meat consumption within the United States.
EVOLUTIONARY GENETICS OF CAVE-DWELLING FISHES OF THE GENUS ASTYANAX.

Attempts to understand evolutionary processes in cave organisms have been largely limited to speculation on the causes of loss of photoreceptor organs and pigmentation, increase in size and complexity of tactile sensory structures, and certain modifications in physiology (see review in Barr, 1968). Little is known of the population genetics of cave organisms or of the genetic changes accompanying the transformation of epigean (surface-dwelling) forms to troglobites (obligate cavernicoles). Yet genetic information is essential to the confident development of theories of troglobite evolution. For this reason, we have compared the genic character and degree of variability in troglobitic and epigean populations of the characid fish Astyanax mexicanus in Mexico. Students of cave biology have generally accepted the thesis that the ancestors of many troglobites entered caves as troglophiles (facultative cavernicoles) before the end of the Pleistocene, and became isolated with the local extinction of surface populations as a result of climatic changes associated with glaciation (Barr, 1968). If this is true, many troglobites have been living
A Gold Nanoparticle Pentapeptide: Gene Fusion To Induce Therapeutic Gene Expression in Mesenchymal Stem Cells

Mesenchymal stem cells (MSC) have been identified as having great potential as autologous cell therapeutics to treat traumatic brain injury and spinal injury as well as neuronal and cardiac ischemic events. All future clinical applications of MSC cell therapies must allow the MSC to be harvested, transfected, and induced to express a desired protein or selection of proteins to have medical benefit. For the full potential of MSC cell therapy to be realized, it is desirable to systematically alter the protein expression of therapeutically beneficial biomolecules in harvested MSC cells with high fidelity in a single transfection event. We have developed a delivery platform on the basis of the use of a solid gold nanoparticle that has been surface modified to produce a fusion containing a zwitterionic, pentapeptide designed from Bax inhibiting peptide (Ku70) to enhance cellular uptake and a linearized expression vector to induce enhanced expression of brain-derived neurotrophic factor (BDNF) in rat-derived MS...
Structural analysis of cofactor binding for a prolyl 4-hydroxylase from the pathogenic bacterium Bacillus anthracis.

The prolyl 4-hydroxylases (P4Hs) are mononuclear nonheme iron enzymes that catalyze the formation of 4R-hydroxyproline from many different substrates, with various biological implications. P4H is a key player in collagen accumulation, which has implications in fibrotic disorders. The stabilization of collagen triple-helical structure via prolyl hydroxylation is the rate-limiting step in collagen biosynthesis, and therefore P4H has been extensively investigated as a potential therapeutic target of fibrotic disease. Understanding how these enzymes recognize cofactors and substrates is important and will aid in the future design of inhibitors of P4H. In this article, X-ray crystal structures of a metallocofactor- and α-ketoglutarate (αKG)-bound form of P4H from Bacillus anthracis (BaP4H) are reported. Structures of BaP4H were solved at 1.63 and 2.35 A resolution and contained a cadmium ion and αKG bound in the active site. The αKG–Cd–BaP4H ternary complex reveals conformational changes of conserved residues upon the binding of metal ion and αKG, resulting in a closed active-site configuration required for dioxygen, substrate binding and catalysis.
Investigation of Influential Factors for Basic Public Health Services in Xuzhou Rural Area

Objective To investigate the influential factors of basic public health services among different township health centers in Xuzhou,so as to carry out this work more balanced. Methods By stratified sampling,total 20 township health centers were selected from 7 counties of Xuzhou and investigated by a self-designed questionnaire. Results There were no significant differences in township health centers scales,number of permanent population,service area,general practitioner annual income,primary health provider annual income and education level among primary health providers. The differences in the number of country doctors,the number of staff in rural prevention centers and the number of people working for basic public health services were significant. Conclusions There were no significant differences in township health center scale or economy. The reason for the imbalance work among different township health centers was the differences in human resources. It is needed to increase professional staff for basic public health services to promote the development of this work.
Epidemiological analysis of syphilis in Dalian from 2004 to 2013

Objective To explore factors related to the increased incidence of syphilis in the recent ten years,and to provide reference for further prevention of syphilis in Dalian. Methods Linear-by-Linear Chi-square test was conducted based on the syphilis data from the national disease surveillance report system from 2004-2013. Results It is indicated that the annual specific incidence rate had been increasing year by year(χ2=7680.9949,P0.01). All the new cases of syphilis,the first-stage cases, the second-stage cases and recessive cases of syphilis were continue to increase. The growth of the first-stage cases and the second-stage cases were sharper than that of recessive cases of syphilis. The number of cases about male and female were similar, but the male-to-female ratio of first-stage syphilis cases was 1 ∶0.51, that of second-stage syphilis cases was 1 ∶1.49. The incidence rate in age group of ≥15 years had been increasing year by year. Cases were predominantly focused on the area city and countryside intersection. Conclusion On the basis of the epidemiology feature of syphilis in Dalian, it is necessary to carry out effective measures to reduce the incidence rate of syphilis.
A Flower and Pod Staging System for Soybean

Flower and pod abscission limit soybean yield. A system for quantifying flower and pod development based on the morphological appearance of the flower prior to and following anthesis has been developed to aid in studies of pod abscission. Changes in the appearance of the corolla, primarily the banner petal, are used to distinguish the different stages of the system. External pistil dimensions have been correlated with internal features for each stage of development. From anthesis to pod set, pistil length and weight increase almost two- and fivefold, respectively, and ovule development progresses from unfertilized egg cells to embryos surrounded by cellular endosperm. Pod dimensions are correlated with ovule length and width and embryo cell number. Flower and pod stages can be determined in situ, thus permitting non-destructive observation and experimental manipulation of flowers or pods without necessarily impeding their development. Stages have been identified that indicate precisely when pod set occurs and when young pods cease growing and ultimately abscise. This system of flower and pod staging is useful in studies designed to assess effects of abiotic or biotic stress and genetic factors on pod set and abortion.
A Blood-Labeling System to Prevent Cross-Contamination and Misadministration

Objective: To avoid misadministrations involving radio-labeled blood products, strict attention must be given to patient identification when blood is drawn or administered and continuous identification of blood samples during radiolabeling. We report on a blood labeling system which we believe safeguards patients. Methods: The dose for a syringe is entered into a computer. A unique color is assigned to each patient and is not reused that day. Labels are printed which designate the patient and procedure and are affixed to syringes, the blood labeling log, all supplies which will contact the blood and a patient ID bracelet. The syringe, ID bracelet and request are verified by two people. When the blood is drawn, the ID bracelet is placed on the patient. Color-coded racks are used to contain all components. Prior to reinjection, the rack contents and final product are verified by two people. Upon reinjection, the ID bracelet is verified then removed. Results: By utilizing this color-coded system, we have virtually eliminated the risk of cross-contamination or misadministration in our nuclear medicine department. Conclusion: This system has been used on 429 patients and neither disrupts nor lengthens the labeling procedure.
Diets and growth of age-0 walleye in a recently recovered population

Most fishes undergo ontogenetic diet shifts, progressing from small to larger prey as they grow. The availability of suitable prey throughout early ontogeny can influence growth, survival and ultimately, year-class strength. Simultaneously, due to their numeric abundance and high mass-specific consumption rates, young fish can serve as influential consumers and thereby affect abundance of various prey. The walleye Sander vitreus population in Saginaw Bay, Lake Huron, recently recovered and is now entirely supported by natural reproduction. Recovery coincided with a dramatic decline of alewife Alosa pseudoharengus, a preferred prey of walleye. Thus, we are uncertain what primary prey now support production of young life stages of this recovered walleye population. To this end, we collected young (larval and later-stage young of year) walleye in Saginaw Bay and characterized their growth, diets and cumulative consumption using bioenergetics models. Young walleye progressed from feeding entirely on zooplankton as larvae in April to feeding almost entirely on fish by September. Based on bioenergetics analyses, fish were the most important prey for young walleye cohorts. Shiners Notropis spp., along with invasive rainbow smelt Osmerus mordax and round goby Neogobius melanostomus, were the primary fish prey. In contrast, yellow perch Perca flavescens, an important prey for adult walleye in Saginaw Bay, were largely absent in young walleye diets. Young walleye growth rates were similar to rates observed in other systems, but lower than growth rates previously observed in Saginaw Bay when alewife were abundant and the density of walleye was low.
Breast Tissue Engineering: Reconstruction Implants and Three-Dimensional Tissue Test Systems

Abstract Breast tissue engineering may provide a biologically-based method for reconstruction following breast cancer surgery (mastectomy or lumpectomy) or for cosmetic augmentation of breast tissue. Breast tissue engineering also may provide a method to develop a personalized benchtop tissue test system that can be used to study a disease, screen drugs or vaccines, or test therapies. This chapter focuses on breast cancer related tissue engineering. Regardless of the endpoint, in vitro or in vivo , certain common approaches and challenges exist in engineering breast tissue. The ability to construct three-dimensional (3D) tissue requires the appropriate selection of cells and biomaterials, and requires the ability to perfuse the tissue. Although early tissue-engineering approaches focused largely on implantation of differentiated cells, more recent attempts use stem or stem-like cells. A wide variety of biomaterial chemistries have been assessed, including naturally derived and synthetic materials, as has a wide variety of formulations and presentations, including injectable and non-injectable. Breast tissue engineering for in vivo application has more constraints than breast tissue engineering for benchtop use; indeed, 3D benchtop tissue systems can be built to replicate aspects of a complex disease state. Additionally, benchtop systems may be used to evaluate and improve tissue-engineering systems for reconstruction, or other medical implants. A large focus is on developing high throughput, high resolution means of building these complex benchtop tissue systems. It is now widely recognized that 3D test systems may provide a missing bridge to better design and understanding of implantable systems and disease states.
Langmuir Turbulence in Coastal Zones: Structure and Length Scales

AbstractLangmuir turbulence is a boundary layer oceanographic phenomenon of the upper layer that is relevant to mixing and vertical transport capacity. It is a manifestation of imposed aerodynamic ...
Time resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors

Granulocyte-colony stimulating factor receptor (G-CSFR) controls myeloid progenitor proliferation and differentiation to neutrophils. Mutations in CSF3R (encoding G-CSFR) have been reported in patients with chronic neutrophilic leukemia (CNL) and acute myeloid leukemia (AML); however, despite years of research, the malignant downstream signaling of the mutated G-CSFRs is not well understood. Here, we used a quantitative phospho-tyrosine analysis to generate a comprehensive signaling map of G-CSF induced tyrosine phosphorylation in the normal versus mutated (proximal: T618I and truncated: Q741x) G-CSFRs. Unbiased clustering and kinase enrichment analysis identified rapid induction of phospho-proteins associated with endocytosis by the wild type G-CSFR only; while G-CSFR mutants showed abnormal kinetics of canonical Stat3, Stat5, and Mapk phosphorylation, and aberrant activation of Bruton’s Tyrosine Kinase (Btk). Mutant-G-CSFR-expressing cells displayed enhanced sensitivity (3–5-fold lower IC50) for ibrutinib-based chemical inhibition of Btk. Primary murine progenitor cells from G-CSFR-Q741x knock-in mice validated activation of Btk by the mutant receptor and retrovirally transduced human CD34+ umbilical cord blood cells expressing mutant receptors displayed enhanced sensitivity to Ibrutinib. A significantly lower clonogenic potential was displayed by both murine and human primary cells expressing mutated receptors upon ibrutinib treatment. Finally, a dramatic synergy was observed between ibrutinib and ruxolinitib at lower dose of the individual drug. Altogether, these data demonstrate the strength of unsupervised proteomics analyses in dissecting oncogenic pathways, and suggest repositioning Ibrutinib for therapy of myeloid leukemia bearing CSF3R mutations. Phospho-tyrosine data are available via ProteomeXchange with identifier PXD009662.
Dural-Based Tumors

Of primary dural-based tumors of the central nervous system, meningiomas are clearly the most commonly encountered and are the primary focus of this chapter. The differential diagnosis of dural-based neoplasms is listed in Table 6.1. Meningiomas arise anywhere in the central nervous system where meningothelial cells can be found, most commonly proximal to the dura. Occasionally, meningiomas arise in unusual places within (such as intraventricular locations) and outside (in ectopic sites such as ear, orbit, skull, and sinuses) the central nervous system.
Toward Precision Policy - The Case of Cardiovascular Care.

Toward Precision Policy Our experience with policies that offer incentives to physicians and hospitals to deliver higher-value care teaches us that before policies are implemented widely, rigorous ...
Pushing Boundaries : Reforming the Digital Youth Agenda through Cultural Competence with Eliza T. Dresang

Artiklen bestemmer kulturel kompetence som evnen til at kende og respektere egen og andres kulturer. I lobet af sin karriere arbejdede Dr. Eliza Dresang intenst for at gore bibliotekernes service og materialer til born mere inkluderende og mere reflekterende i relation til borns forskellige kulturer og faellesskaber. Selvom Dresang blev mest kendt for sin teori 'Radikal aendring' (1999), kaempede hun for alle borns rettigheder pa biblioteker. Denne artikel giver et signalement af Dresangs arbejde med multikulturel litteratur og kulturel kompetence. Den beskriver udviklingen af et bibliotekskursus baseret pa viden om kulturel kompetence og den ender med at opsummere de forelobige resultater fra to forskningsprojekter, der forsoger at demonstrere og empirisk underbygge betydningen af kulturel kompetence bade for digitale unge og for de voksne, der arbejder sammen med dem.
Active surveillance and watchful waiting for low-risk prostate cancer in black patients: A population-based analysis.

10Background: Evidence from clinical trials supports conservative management as an acceptable alternative to definitive therapy for low-risk prostate cancer (LRPC). The optimal approach for Black m...
The Test of Time.

Roger Bacon (1214-1294) wrote in his Opus Majus, "If in other sciences we should arrive at certainty without doubt and truth without error, it behooves us to place the foundations of knowledge in mathe matics" (Bacon 1962,116). We trust mathematics with our lives. Where would we be if the power grid blacked out, if all our computers crashed, or even if something simple like the sequencing of traffic lights failed? We trust mathematics. But what is it about mathematics that earns our trust? We have at least three reasons for trusting math ematics, three reasons to believe that mathemati s gives answers more reliable than many a pronounce ment of pundit and sage. This article considers each in turn.
Technology, Labor and Globalization: Contemporary Challenges

From 2008, the world economy has been hit by a series of negative shocks and seems to be suffering from one of the most long-drawn recessions in history. It is argued that one underlying factor driving this festering crisis is the rise of digital technology which is reducing the demand for labor and creating an increasingly common labor market for the world. The paper elaborates on this hypothesis and goes on to discuss how this is impacting India and presents ideas on how India should respond to it in the future.
Depression Is Not Gender-Biased: Maternal and Paternal Depression and Early Parent-Infant Interactions

Experiencing depressive symptoms in the postpartum period is common among new parents. When symptoms are severe or chronic, they can affect parents’ daily functioning, parenting practices, and interactions with their infants. In turn, impaired parent-infant interactions contribute to adverse developmental outcomes for infants of depressed parents. We discuss potential underlying mechanisms that link maternal and paternal depression to adverse consequences for infants’ development. Using the mutual regulation model as a theoretical frame, we review central characteristics of the early parent-infant interaction in the context of parental depression and discuss how psychopathology and child gender differences may alter these interactions and increase infant vulnerability. Finally, we consider environmental and biological factors that contribute to individual risk and resilience beyond the parent-infant interaction.
A Doubly-Inflated Poisson Distribution and Regression Model

A doubly-inflated Poisson distribution is presented to account for count inflation at some positive integer value k in addition to that seen at zero. Maximum likelihood and moment estimators are derived, and their performances are compared using asymptotic relative efficiencies. The doubly-inflated Poisson distribution is also incorporated into the generalized linear models framework to account for associations with covariates in modeling the count mean as well as the probability of inflation.
Early radiographic failure of reverse total shoulder arthroplasty with structural bone graft for glenoid bone loss.

Introduction Structural glenoid bone grafting in reverse total shoulder arthroplasty (RSA) has previously been reported to have good functional outcomes and low complication rates. We have observed different complication rates and hypothesized that baseplate fixation and severity of deformity may be predictors of early failure. Methods We retrospectively identified 44 patients who underwent RSA with structural bone grafting for glenoid bone defects. All patients had preoperative and postoperative (Grashey and axillary) radiographs at a minimum of 1 year after surgery and within 3 months of surgery for evaluation of implant and graft positioning. Clinical data and outcome scores were collected at the same intervals. Results There were 61% females and 39% males, with an average age of 74 ± 8 years at the time of surgery. The median final radiographic follow-up was 20 months, with 37 primary RSA and 7 revision RSA. Graft resorption was found in 11 of 44 patients (25%), and radiographic failure was found in 11 of 44 patients (25%) at a median of 8 months (range 3-51 months). Forward elevation, American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form, Single Assessment Numeric Evaluation (SANE), and Simple Shoulder Test (SST) scores all significantly improved postoperatively (P Discussion/Conclusion RSA with structural bone graft improved range of motion and function, but there was a larger than previously reported baseplate loosening rate. This early radiographic loosening appeared to be associated with graft resorption, retroversion correction, and worse outcome scores.
Improving Satisfaction With Operating Room Feedback: An Effective, Low-Profile, No-Cost Intervention

OBJECTIVE The objective of this study was to develop and implement an effective and minimally invasive tool to enhance formative and goal specific feedback for general surgery residents in the operating room. DESIGN Placards reminding surgical faculty and residents to engage in goal directed feedback were installed at scrub sinks outside of every operating room. The purpose was to encourage both residents and faculty to agree on a learning goal before the case, teach and learn that goal during the case, and discuss progress and next steps after the case. Preintervention and postintervention questionnaires were administered via Qualtrics Online Survey Software to all general surgery residents and core faculty members. SETTING Placards were installed at every scrub sink across all 4 hospitals associated with Yale School of Medicine General Surgery Residency over a 6-month time period. PARTICIPANTS Respondents included general surgery residents and core surgical faculty of the Yale School of Medicine General Surgery Residency. RESULTS Following the intervention, residents reported a statistically significant increase in preoperative discussion of learning goals, debriefing about specific learning goals postoperatively, and overall satisfaction with feedback (p CONCLUSIONS Formative feedback reminder placards placed near operating rooms serve as a low-profile, no-cost intervention to improve general surgery resident satisfaction with operative feedback and increase the perceived rate of goal specific feedback discussions both pre- and postoperatively.
Using Community Pharmacy Immunization Screening Forms to Identify Potential Immunization Opportunities

Immunization screening forms are completed for each patient that is to be vaccinated in the pharmacy. Screening forms contain demographic and health questions, which are used to determine if a patient is contraindicated to receive a vaccine. The objective is to determine if patient responses to questions on these forms can be used to identify potential vaccine indications. De-identified data was retrospectively collected from 11 community pharmacies in California and Michigan that included basic demographics, answers to immunization screening questions, and vaccine(s) administered during that visit. The Advisory Committee on Immunization Practices (ACIP) recommendations were used to forecast vaccine needs using the limited demographic and health history available from the screening forms. Descriptive statistics are presented, characterizing patient demographics and health condition-based recommendations, and the percentage of patients in a pharmacy population that may have potential indications for additional vaccines. Data were collected from 8669 pharmacy vaccine screening forms. Using the patient's date of birth on the screening form, 10% (n = 759) and 34.6% (n = 2615) of patients receiving vaccines at the pharmacy may be indicated for the zoster, or both the zoster and pneumococcal vaccines, respectively. Screening form questions that inquire about medical history are also able to identify 13.9% (n = 977) of patients with a potential need for pneumococcal vaccines. Our data indicate that pharmacists can identify potential immunization opportunities proactively by using their immunization screening form, not only to identify contraindications, but also indications.
Phase I trial of everolimus, gemcitabine and cisplatin for patients with solid tumors refractory to standard therapy.

e13052 Background: The combination of GEM and CDDP has shown activity in a variety of cancers, including biliary tract/gallbladder. Preclinical testing shows a potential benefit to the addition of ...
Abstract PR3: Development of a transcriptomic T-cell atlas highlights the differential role of T-cell subpopulations in CAR T-cell therapy resistance

Chimeric antigen receptor (CAR) T-cell therapy has been a major breakthrough in B-cell acute lymphoblastic leukemia (B-ALL), yet therapeutic resistance remains an important clinical challenge. Given that approximately 20% of patients do not respond to therapy and 40% of initial responders relapse within a year, there is a pressing need to understand the basis of therapy resistance in order to identify prognostic biomarkers and improve the therapeutic modality. We hypothesize that intrinsic T-cell factors are a major contributor to early therapeutic failure to CAR T-cell therapy. Most protocols do not select for specific T-cell subtypes, leading to the use of heterogeneous T-cell populations for CAR T-cell engineering. In order to characterize the molecular phenotypes of T cells underlying therapeutic response, we performed subtype-specific transcriptomic profiling of clinical T-cell populations in patients subsequently treated with anti-CD19 CAR T-cell therapy. We identified 71 patients with B-ALL treated with CAR T-cell therapy at the Children’s Hospital of Philadelphia, and obtained T cells via clinical leukapheresis prior to CAR T-cell engineering. We used FACS to separate T cells into five subtypes per patient (Naive, Stem Cell Memory, Central Memory, Effector Memory, and Effector), and performed bulk RNA-sequencing on all 355 samples. To our knowledge, this is the largest and most comprehensive transcriptomic profiling of clinical T cells in CAR T-cell therapy to date. We find that a higher proportion of CCR7+CD62L+ naive and early memory T-cell phenotypes associates with longer clinical T-cell persistence (HR=3.25 [1.37-7.89], p=0.006), and that combining proportions of these populations with CCR7−CD62L−CD45RO+CD95+ effector memory T cells has the greatest prognostic value (HR: 4.82 [1.89-12.32]; p This abstract is also being presented as Poster A65. Citation Format: Gregory M. Chen, Changya Chen, Rajat K. Das, Yang-Yang Ding, Bing He, Hannah Kim, David M. Barrett, Kai Tan. Development of a transcriptomic T-cell atlas highlights the differential role of T-cell subpopulations in CAR T-cell therapy resistance [abstract]. In: Proceedings of the AACR Special Conference on Tumor Immunology and Immunotherapy; 2019 Nov 17-20; Boston, MA. Philadelphia (PA): AACR; Cancer Immunol Res 2020;8(3 Suppl):Abstract nr PR3.
Biopsychosocial factors and health outcomes associated with cannabis, opioids and benzodiazepines use among older veterans.

Background: Older Veterans may experience injuries that result in chronic pain and mental health conditions. Given the increasing availability of medical cannabis, it is important to examine if it ...
The taquito hot seat: Socializing monolingual bias through error correction practices in a Portuguese language classroom

Portuguese language students in the United States typically also speak Spanish, and Portuguese programs, influenced by ideologies of linguistic purism, ceaselessly battle against its interference. This article describes a qualitative study of the treatment of Spanish utterances—called taquitos by participants—in a beginner-level Portuguese class. It presents the classroom as a space of language socialization where students are apprenticed into a culture of strict language separation that demonstrates our field's monolingual bias. Microanalysis of videorecorded classes shows how error correction practices socialize students into upholding monolingual immersion through constant vigilance and mobilization against taquitos. Gaze, body orientation, and gestures as attention markers reveal a taquito hot seat that marginalizes and places Spanish-speaking students in intense negative focus for not producing Portuguese in “uncontaminated” forms. Given the harm such practices may cause, the article urges the field to examine our rigid insistence upon artificial classroom monolingual immersion and promote flexible, strategic translanguaging for more effective world language pedagogy.
Canada's "Newfyjohn" Tenancy: The Royal Canadian Navy in St. John's, 1941-1945

"The rcn in ST. JOHN'S was something like a tenant living rent-free in a house which he himself had designed, of which he paid for the upkeep and in which members of the landlord's family were welcome to take shelter". 1 This reflection on the Royal Canadian Navy's wartime presence in St. John's was published in 1952, only three years after Newfoundland entered Confederation. Since that time scholars have only slowly turned their attention to studying the Canadian impact in Newfoundland during the Second World War.2 The war brought an unprecedented prosperity to Newfoundland, through the major investment and expenditures associated with elaborate American and Canadian naval, military and air bases developed after 1941. By the time Newfoundland was plunged into debates about the country's future at the end of the war, it has been argued, the wartime experience had "strengthened the relationship between the island and the mainland, and in general had created a climate in which Confederation could be seen as an attractive option".3 During the Second World War Newfoundland occupied a vital position in the North Atlantic theatre of operations. The protection of supply lines to a beleaguered Great Britain became a priority for Allied naval strategy and resulted in the formation of the RCN's Newfoundland Escort Force in 1941. From the outset, the RCN faced the enormous challenge of providing from scratch workable logistic support for this new fleet in a location remote from its established Atlantic bases. As the Battle of the Atlantic intensified, the escort fleet experienced serious operational problems resulting from equipment and training shortfalls. Its Newfoundland base in St. John's exhibited similar flaws in repair and maintenance capability, berthage and drydock service and in almost every aspect of technical support. These difficulties would never fully be surmounted despite substantial investment by Canada in port facilities and naval installations in St. John's, which by 1944 amounted to more than $16 million. Politically, Canadian economic and strategic commitments gained recognition of its special interest in the defence of Newfoundland from its United States and British allies. Moreover, as
Raf-1 kinase possesses distinct binding domains for phosphatidylserine and phosphatidic acid. Phosphatidic acid regulates the translocation of Raf-1 in 12-O-tetradecanoylphorbol-13-acetate-stimulated Madin-Darby canine kidney cells.

Previous studies demonstrated that the cysteine-rich amino-terminal domain of Raf-1 kinase interacts selectively with phosphatidylserine (Ghosh, S., Xie, W. Q., Quest, A. F. G., Mabrouk, G. M., Strum, J. C., and Bell, R. M.(1994) J. Biol. Chem. 269, 10000-10007). Further analysis showed that full-length Raf-1 bound to both phosphatidylserine and phosphatidic acid (PA). Specifically, a carboxyl-terminal domain of Raf-1 kinase (RafC; residues 295-648 of human Raf-1) interacted strongly with phosphatidic acid. The binding of RafC to PA displayed positive cooperativity with Hill numbers between 3.3 and 6.2; the apparent Kd ranged from 4.9 ± 0.6 to 7.8 ± 0.9 mol % PA. The interaction of RafC with PA displayed a pH dependence distinct from the interaction between the cysteine-rich domain of Raf-1 and PA. Also, the RafC-PA interaction was unaffected at high ionic strength. Of all the lipids tested, only PA and cardiolipin exhibited high affinity binding; other acidic lipids were either ineffective or weakly effective. By deletion mutagenesis, the PA binding site within RafC was narrowed down to a 35-amino acid segment between residues 389 and 423. RafC did not bind phosphatidyl alcohols; also, inhibition of PA formation in Madin-Darby canine kidney cells by treatment with 1% ethanol significantly reduced the translocation of Raf-1 from the cytosol to the membrane following stimulation with 12-O-tetradecanoylphorbol-13-acetate. These results suggest a potential role of the lipid second messenger, PA, in the regulation of translocation and subsequent activation of Raf-1 in vivo.
A Multilevel Multiscale Mimetic (M3) Method for an Anisotropic Infiltration Problem

Modeling of multiphase flow and transport in highly heterogeneous porous media must capture a broad range of coupled spatial and temporal scales. Recently, a hierarchical approach dubbed the Multilevel Multiscale Mimetic (M3) method, was developed to simulate two-phase flow in porous media. The M3 method is locally mass conserving at all levels in its hierarchy, it supports unstructured polygonal grids and full tensor permeabilities, and it can achieve large coarsening factors. In this work we consider infiltration of water into a two-dimensional layered medium. The grid is aligned with the layers but not the coordinate axes. We demonstrate that with an efficient temporal updating strategy for the coarsening parameters, fine-scale accuracy of prominent features in the flow is maintained by the M3 method.
Effects of Growth at Low Water Activity on the Thermal Tolerance of Staphylococcus aureus

Staphylococcus aureus is the most osmotolerant foodborne pathogen, and outbreaks of staphylococcal food poisoning are often linked to foods of reduced water activity (aw) values. While it is generally known that the thermal tolerance of microorganisms increases as the aw of the heating menstruum is decreased, surprisingly little research has examined the influence of growth medium aw on microbial thermal tolerance. In the present study, we show that growth of S. aureus at an aw value of 0.94 leads to the development of dramatically enhanced thermal tolerance (i.e., less than 1 log reduction after heating for 20 min at 60°C). We further show that the identity of the accumulated compatible solute within cells grown at low aw can also influence the overall level of thermal tolerance of S. aureus. Finally, we provide evidence that the synthesis of general stress and/or osmotic stress proteins is required for the development of enhanced thermal tolerance of S. aureus at low aw.
Pi-PIFO: A scalable pipelined PIFO memory management architecture

Quality of service (QoS) provisioning is rapidly becoming an assumed attribute of core packet switching systems. Substantial work has been focused on designing algorithms which offer strict QoS guarantees under a broad range of traffic scenarios. The majority of these scheduling algorithms can be realized utilizing Push-in-First-out (PIFO) queues, which are characterized by allowing packets to enter the queue at arbitrary locations while departures occur from the head of line position only. Although the PIFO queueing mechanism has received attention in recent years, it is generally considered impractical from a hardware implementation perspective. This is due primarily to the computational complexity involved in placing arriving packets in a generic PIFO queue. In recent work, the iPIFO memory management scheme has been proposed in which additional data structures are employed to facilitate the realization of PIFO queues. While iPIFO does overcome some of the complexities involved in implementing PIFO queueing, it relies on the existence of a high-speed memory device which supports a large number of concurrent read and write operations. Such assumption substantially limits scalability. This paper introduces Pi-PIFO, a pipelined PIFO queuing memory management architecture, which requires modest memory bandwidth, with sub-linear dependency on the queue size (N), thereby overcoming the limitations previously associated with realizing PIFO queueing. Moreover, the logic complexity of the architecture is O(logN), rendering the approach highly scalable with respect to switch port densities and speeds.
Modelling content lifespan in online social networks using data mining

Online social networks OSNs are integrated into business, entertainment, politics, and education; they are integrated into nearly every facet of our everyday lives. They have played essential roles in milestones for humanity, such as the social revolutions in certain countries, to more day-to-day activities, such as streaming entertaining or educational materials. Not surprisingly, social networks are the subject of study, not only for computer scientists, but also for economists, sociologists, political scientists, and psychologists, among others. In this paper, we build a model that is used to classify content on the OSNs of Reddit, 4chan, Flickr, and YouTube - according the types of lifespan their content have and the popularity tiers that the content reaches. The proposed model is evaluated using ten-fold cross-validation, using data mining techniques of sequential minimal optimisation based on support vector machine, decision table, Naive Bayes, and random forest. The run times and accuracies are compared across OSNs, models, and data mining algorithms.
THE ZINC CONTENT OF PANCREATIC SECRETION.

Summary Duodenal aspiration in seven normal subjects after secretin stimulation showed a mean secretion of 142 μg of zinc in 60 min with a range of 118 to 210,μg. Patients with chronic pancreatitis responded to secretin with lower total volumes, bicarbonate concentration and zinc content. Zinc concentration was also depressed. Cirrhotic patients excreted significantly less zinc than normal subjects although total volume of secretion was larger and the total bicarbonate excretion was within normal limits.
Residual Stress Distributions in the Solid Solution Eutectic, Co1−xNixO/ZrO2(CaO)

This study investigates thermal mismatch stresses in the lamellar microstructure of the solid solution directionally solidified eutectic (DSE) oxide Co1−xNixO/ZrO2(CaO). X-ray and neutron diffraction measurements were performed on isolated eutectic domains to measure the residual strain and stress tensors. Maximum principal residual stresses on the order of 1 GPa were recorded, with the Co1−xNixO and the ZrO2(CaO) phases maintaining states of tensile and compressive stress, respectively. The stress tensors for these materials are compared with measurements for similar DSE oxide systems and suggest that solid solution DSEs might be used to tailor the residual stress states in DSE composites.