cssi/SciSciGPT-SciSciNet huggingface dataset:
Effects of VA-mycorrhizae and nitrogen sources on rhizosphere soil characteristics, growth and nutrient acquisition of coffee seedlings (Coffea arabica L.)

Effects of N sources (ammonium, nitrate and ammonitrate) and VA mycorrhizae (Glomus intraradices) on rhizosphere soil characteristics (pH, exchangeable acidity, exchangeable cations, inorganic N concentrations) growth and nutrient acquisition of coffee seedlings (Coffea arabica L. cv guatemala) were investigated in a pot study with an acid soil (Red Bluff Loam) sterilized by autoclaving. Ammonium addition decreased rhizosphere pH while nitrate and ammonitrate additions both increased rhizosphere pH. Mycorrhizae induced a higher pH, a lower exchangeable acidity and higher values of exchangeable cations in the rhizosphere. Ammonium addition resulted in a lower mycorrhizal infection than the two other N sources. Mycorrhizal plants grew better and accumulated more N, Ca and Mg than non-mycorrhizal plants.
The Ranking of Masters Programs in International Business – Reply

The thrust of many of Professor Douglas' criticisms makes it appear to me that she did not realize that this was an educational "Note." It was not published among the research articles in JIBS. As a Note, space could not be used to discuss the details of the research methodology and the limitations of the analytical technique. They were referred to, but not in the detail that Professor Douglas and I would have preferred.
Histochemical Characteristics of the Endometrial Surface Related Temporally to Implantation in the Non-Human Primate (Macaca fascicularis)

Appropriate differentiation of the trophoblast is surely requisite for blastocyst invasion. However, there is overwhelmingly compelling evidence to suggest that differentiation of the endometrium into a “receptive state” is the primary determinate of successful nidation. The highly invasive trophoblast of certain species appears able to “implant” almost without discrimination in a variety of ectopic sites, regardless of the host tissue or the hormonal milieu (Kirby, 1971). Conspicuously, the only tissue in which trophoblastic invasion does no. occur indiscriminately is the natural implantation site, the uterine lining. The uterus is permissive to blastocyst implantation for only a brief interval or “receptive window” following appropriate hormonal conditioning (Casimiri and Psychoyos, 1981), as evidenced by the failure of transferred blastocysts to attach to endometrium except at the time of normal receptivity for that species (Finn, 1977). Further evidence is derived from observations that peri-ovulatory administration of progesterone leads to implantation failure due to embryo-uterine asynchrony in rats, rabbits and (albeit debated) humans (Psychoyos, 1976; Schacht and Foote, 1978; Trounson et al., 1986).
Martha and the Masters: Virtuous Domestic Aesthetic Activity

In this essay, I draw Karen Stohr’s work on the moral-aesthetic elements of hospitality into conversation with classical Confucianism. While the early Confucians would not deny the other-regarding elements of hospitality Stohr emphasizes, they also notably highlight the ways exercises in taste and skillful aesthetic activity can work on and for the agent herself, providing a sensibility that can guard domestic aesthetic activity against problematic forms of self-sacrifice and alienated labor that color contemporary gendered representations of the home and its activity. The most robustly virtuous and indeed rewarding versions of hospitality and domestic aesthetic activity, I argue, will link self to environment and work, using both as mechanisms that foster wider values the self prizes and endorses.
Abstract 1413: Rapamycin inhibits lymph node metastasis in an orthotopic model of head and neck squamous cell carcinoma: A possible role for a suppression of VEGFR-3 expression

Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Background: Tumor cell dissemination to cervical lymph nodes via the lymphatic system represents the first step in the metastasis of head and neck squamous cell carcinoma (HNSCC) and is the most significant prognostic factor for tumor recurrence decreasing survival by 50%. The anti-lymphangiogenic properties of mTOR inhibitors are not yet well understood nor have the effects of rapalogues’ on tumor-associated lymphangiogenesis been investigated in HNSCC. Methods: The lymphatic suppressing effects of rapamycin were evaluated in vitro using lymphatic endothelial cell lines (SV-LEC; HMEC-1a). An orthotopic model of HNSCC was used to evaluate anti-lymphangiogenic effects of rapamycin in vivo. OSC-19 cells were injected into the basolateral tongue of SCID mice. After 5 days mice were given daily IP injections of vehicle (control group) or rapamycin at 5 mg/kg. On day 21 after OSC-19 administration mice were sacrificed and tongues, cervical lymph nodes and serum collected. The incidence of cervical lymph node metastasis, the number of tumor-free and tumor-associated lymphatic vessels in mouse lingual tissue, and expression of pro-lymphangiogenic markers were assessed. Results: We found that LEC proliferation was significantly reduced by rapamycin. LEC growth inhibition by rapamycin was linked with decreased expression of VEGFR-3 in both LECs, and in some HNSCC cell lines. Rapamycin significantly lowered the fraction of tumor-associated lymphatic vessels in mouse tongues (p=0.0167) and decreased the number of metastasis-positive lymph nodes (p=0.04). Rapamycin also significantly attenuated the extent of metastatic tumor cell spread within the lymph nodes (p<0.0001). Conclusion: The results of this study demonstrate anti-lymphangiogenic properties of mTOR inhibitors in HNSCC. These findings provide preclinical data showing that rapalogues exert anti-lymphatic effects in head and neck cancer via suppressing ofVEGFR-3 expression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1413. doi:1538-7445.AM2012-1413
Intrinsic Point Defects and Diffusion Processes in Silicon

This paper reviews recent progress in understanding the role of vacancies (V) and self-interstitials (I) in self and impurity diffusion in Si. Surface oxidation perturbs the thermal equilibrium concentration of point defects and analyses of the resulting effects on dopant diffusion showed that both V and I are present. Developments in experimental and theoretical works on Au diffusion in Si yielded a determination of the I-component and an estimate of the V-component of the Si self-diffusion coefficient. It is hoped that the I and V thermal equilibrium concentrations may be determined in the near future.A number of important physical aspects of the anomalous diffusion of P are now understood but a basically satisfactory model may need further work.
Role of autologous bone marrow transplantation in acute leukemia.

With conventional-dose chemotherapy, the prognosis of adult acute leukemia varies with morphological type from 25% longterm disease-free survival (DFS) in acute myelogenous leukemia (AML) to 40% in acute lymphocytic leukemia (ALL). For this reason, we would like to discuss the role of autologous bone marrow transplantation (ABMT) separately for each disease modality.
Ethanol and sugarcane expansion in Brazil: what is fueling the ethanol industry?

This case study describes Brazilian ethanol industry and strategic issues faced by sugarcane farmers and processors as a result of recent industry expansion into the states of Goias and Mato Grosso do Sul. It provides detailed description of the ethanol supply chain in Brazil from field to market and discusses market drivers influencing the industry. Shaped by government regulations, market liberalization, globalization, and technological change, the Brazilian ethanol industry provides a rich context for learning and applying strategic analysis tools. The case is designed to be used in a graduate or undergraduate agribusiness management or strategic management course. The specific teaching objective for this case is to refine and reinforce students’ understanding of industry analysis and the effect of market drivers on competitive forces in an industry. Students will be expected to conduct an industry analysis and provide strategy recommendations to managers of ethanol plants and farmers. The case study i...
Inertial particle dynamics in large artery flows – Implications for modeling arterial embolisms

The complexity of inertial particle dynamics through swirling chaotic flow structures characteristic of pulsatile large-artery hemodynamics renders significant challenges in predictive understanding of transport of such particles. This is specifically crucial for arterial embolisms, where knowledge of embolus transport to major vascular beds helps in disease diagnosis and surgical planning. Using a computational framework built upon image-based CFD and discrete particle dynamics modeling, a multi-parameter sampling-based study was conducted on embolic particle dynamics and transport. The results highlighted the strong influence of material properties, embolus size, release instance, and embolus source on embolus distribution to the cerebral, renal and mesenteric, and ilio-femoral vasculature beds. The study also isolated the importance of shear-gradient lift, and elastohydrodynamic contact, in affecting embolic particle transport. Near-wall particle re-suspension due to lift alters aortogenic embolic particle dynamics significantly as compared to cardiogenic. The observations collectively indicated the complex interplay of particle inertia, fluid-particle density ratio, and wall collisions, with chaotic flow structures, which render the overall motion of the particles to be non-trivially dispersive in nature.
Investigational new drugs for allergic rhinitis.

ABSTRACTIntroduction: Allergic rhinitis (AR) is a multifactorial disease characterized by paroxysmal symptoms of sneezing, rhinorrhea, postnasal drip and nasal congestion. For over a century, subcutaneous allergen immunotherapy (SCIT) has been recognized as the most effective therapy to date that may modify the underlying disease course and provide long-term benefits for individuals refractory to pharmacotherapy. However, over the past 25 years, there has been substantial growth in developing alternative therapies to traditional SCIT.Areas covered: This article will review the most current literature focusing on advancements of AR therapies. Novel AR therapies that are currently under investigation include: the addition of omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody (mAb), to SCIT; altering the method of delivery of allergen immunotherapy (AIT) including sublingual (SLIT), epicutaneous (EIT), intralymphatic (ILIT), intranasal (INIT) and oral mucosal immunotherapy (OMIT); use of capsaici...
Thoracic Paravertebral Block

: Primarily used for postoperative pain control for procedures at level of thoracic vertebrae, such as mastectomy, open cholecystectomy, or thoracotomy. May also be performed for acute pain control associated with trauma (rib fractures) or chronic pain (herpetic neuralgia, chronic postsurgical pain).
“Supervision by Public Opinion” or by Government Officials? Media Criticism and Central-Local Government Relations in China:

Despite the sophisticated control of media in China, criticism of the party-state is not uncommon. Why does the authoritarian regime allow criticism? This article offers an explanation based on pol...
Delivery of high quality uncompressed video over ATM to windows NT desktop

The emergence of high bandwidth applications such as medical visualization and virtual reality has exposed significant deficiencies in network, protocol, and end-system design. In this paper we discuss important end-system issues which arise when supporting applications demanding networked delivery and manipulation of uncompressed video to the desktop. Our experimental network environment consists of DEC Alpha workstations using the Windows NT 4.0 operating system and connected via an ATM switch. We present the design and initial results of a network architecture that demonstrates the creation, manipulation, and distribution of high-quality uncompressed video using standard industry-based technologies. In addition, we discuss networking performance results and present a simple Windows Sockets 2.0 cost model for TCP/IP and UDP/IP over ATM. An early potential market where this work is expected to have a direct impact is video editing in motion picture and television studios. In this context, we hope to provide cost-effective networked solutions aimed at replacing costly dedicated video editing hardware with the versatile capabilities of general purpose workstations and nonproprietary network solutions.
Influence of Previous Fruit Injury on Susceptibility to Spotted Wing Drosophila (Diptera: Drosophilidae) Infestation in the Midwestern United States

Abstract Spotted wing drosophila, Drosophila suzukii (Matsumura), is a major agricultural pest throughout most of the fruit growing regions of the United States, with high reproductive rates and short generation times resulting in exponential population growth in berry crops across the country. Fruit suitability research has been conducted for some small fruit species such as raspberries, strawberries, cherries, and blackberries; however, there is a paucity of data regarding the role of previous injury on host susceptibility and suitability for D. suzukii. This study examined the role of previous fruit injury on adult D. suzukii survival, adult production, and host susceptibility, with injury referring to physiological splitting, disease, and vertebrate feeding. Results indicate that intact raspberries, blueberries, and table grapes are susceptible to oviposition by D. suzukii and the presence of injury increases survival of both male and female flies. When fruit was injured, berry infestation levels inc...
Reducing emergency department visits utilizing a primary care asthma specialty clinic in a high-risk patient population.

ABSTRACTObjective: Asthma is a leading cause of pediatric emergency department (ED) use. Optimizing asthma outcomes is a goal of Nationwide Children's Hospital (NCH) and its affiliated Accountable Care Organization. NCH's Primary Care Network, comprised of 12 offices serving a predominantly Medicaid population, sought to determine whether an Asthma Specialty Clinic (ASC) operated within a single primary care office could reduce ED asthma rates and improve quality measures, relative to all other network offices. Methods: An ASC was piloted with four components: patient monitoring, provider continuity, standardized assessment, and multi-disciplinary education. A registry was established to contact patients at recommended intervals. At extended-length visits, a general pediatrician evaluated patients and a multi-disciplinary team provided education. Novel educational tools were utilized, guideline-based templates recorded and spirometry obtained. ED asthma rate, spirometry utilization, and controller fills b...
Transumbilical extracorporeal laparoscopic-assisted appendectomy.

Abstract Aim of the study The perfect balance between safety, cosmesis, and cost effectiveness in a world with ever growing healthcare costs has yet to be found for nonperforated appendicitis. The aim is to present our data regarding safety and cost effectiveness of the transumbilical extracorporeal laparoscopic-assisted appendectomy technique. Methods A retrospective review was performed for all laparoscopic appendectomies for acute appendicitis from October 2014 to October 2016. All cases of perforated appendicitis were excluded (visible hole/abscess/free pus). Included cases were divided into two groups by operative technique: transumbilical (TU) or laparoscopic 3-port (L3P). Operating room charges were billed in 30-min intervals, and hospital charges billed per night in-house. The technique was that the appendix is identified with the laparoscope, grabbed with a grasper that is inserted parallel to the laparoscope, and exteriorized through the umbilicus. The appendectomy is completed extracorporeally. Results A total of 494 cases of nonperforated appendicitis were included in the study. One surgeon attempted all cases with the TU technique (n=161), and all other surgeons used the L3P technique (n=333), which required an endostapler and a vascular sealing device. The TU technique was successful in 99 of the attempted cases. The mean operative time of the TU cases and the L3P cases was 21 (8–43) and 37 (12–73) min, respectively ( P P Conclusion The transumbilical extracorporeal laparoscopic-assisted technique was as safe as the laparoscopic 3-port technique. It offered all the advantages of a minimally invasive procedure, was associated with a significantly shorter hospital stay, and was remarkably more cost effective than the standard laparoscopic 3-port technique. Level of evidence III
Critical Race Theory: A Content Analysis of the Social Work Literature

Critical Race Theory (CRT) is both a theoretical and practical framework, which promotes a space to deeply engage in discourses of race. CRT highlights the importance of conceptualizing race, racism, power dynamics and structural inequalities. Although the social work profession emphasizes the importance of integrating cultural and racial diversity into social work education, practice and research, the integration of CRT within social work will promote racial competency essential for social work professionals. This article reviewed 14 social work peer-reviewed articles exploring the need to integrate Critical Race Theory.
Regulation of Cytosolic Sulfotransferases in Models of Human Hepatocyte Development

Cytosolic sulfotransferases (SULTs) are expressed during early life and therefore metabolize endogenous and xenobiotic chemicals during development. Little is currently known about the regulation of individual SULTs in the developing human liver. We characterized SULT expression in primary cultures of human fetal hepatocytes and the HepaRG model of liver cell differentiation. SULT1A1 (transcript variants 1-4), SULT1C2, SULT1C4, SULT1E1, and SULT2A1 were the most abundant transcripts in human fetal hepatocytes. In HepaRG cells, SULT1B1, SULT1C2/3/4, and SULT1E1 mRNA levels increased during the transition from proliferation to confluency and then decreased as the cells underwent further differentiation. By contrast, SULT2A1 mRNA levels increased during differentiation, whereas SULT1A1 and SULT2B1 mRNA levels remained relatively constant. The temporal patterns of SULT1C2, SULT1E1, and SULT2A1 protein content were consistent with those observed at the mRNA level. To identify regulators of SULT expression, cultured fetal hepatocytes and HepaRG cells were treated with a panel of lipid- and xenobiotic-sensing receptor activators. The following effects were observed in both fetal hepatocytes and HepaRG cells: 1) liver X receptor activator treatment increased SULT1A1 transcript variant 5 levels; 2) vitamin D receptor activator treatment increased SULT1C2 and SULT2B1 mRNA levels; and 3) farnesoid X receptor activator treatment decreased SULT2A1 expression. Activators of aryl hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, and peroxisome proliferator-activated receptors produced additional gene-dependent effects on SULT expression in HepaRG cells. These findings suggest that SULT-regulating chemicals have the potential to modulate physiologic processes and susceptibility to xenobiotic stressors in the developing human liver.
An Integrated Approach to the Treatment and Rehabilitation of Persons with Schizophrenia

Persons with schizophrenia can substantially improve their functional capacity, quality of life and psychopathology if they are afforded an integrated mode of treatment and rehabilitation that is characterized by (a) the five “C’s” of high quality treatment, (b) an effective treatment delivery system, and (c) phase-specific interventions. The five “C’s” delineate the quality and adequacy of the treatment and rehabilitation, the delivery system assures that the various assessments and interventions are imbedded in an outreach program that brings the treatment to the patient, as necessary, in a flexible manner, that is consistent with the phase or type of disorder.
Disease Severity and Disease Trajectory of Amyotrophic Lateral Sclerosis (ALS) Patients at Frist Clinic Visit Measured Prospectively with "ALS Dashboard" – A Six-Domain (Cognition, Affect, Bulbar, Respiratory, Arm, Leg) Staging System – Comparison of Two Cohorts (P07.088)

OBJECTIVE: Determine prospectively the distribution of clinical stages in people with ALS, at the time of first clinic visit 2009-2011 and diagnosis according to the "ALS Dashboard" staging algorithm compared with a cohort from 1998-2001. BACKGROUND: While the time from disease onset to disease diagnosis has been studied in several populations of people with ALS, the disease burden at first clinic visit and at diagnosis has been less carefully analyzed. DESIGN/METHODS: From 2009-2011 181 patients [101 M; 80 F] were referred to the Carolinas Neuromuscular/ALS-MDA Center. 17 were found not to have ALS. The remaining patients were staged according to the "ALS Dashboard" staging algorithm in cognitive, affect, bulbar, respiratory, arm and leg domains. Age at diagnosis, site of onset, time from onset to diagnosis, vital capacity at diagnosis, ALSFRS-R total and bulbar, arm, leg, respiratory subscores at diagnosis were calculated. Domain-specific stage at diagnosis and at three month intervals after diagnosis were established for each patient. Distribution of domain-specific staging at first clinic visit was compared with a previous cohort from 1998-2001. Statistical analysis was performed with MedcCalc software version 12. 2.1 [www.medcalc.org/]. RESULTS: Cognitive stage ≥ 3 present at diagnosis was increased in the 2009-2011 cohort compared with the 1998-2001 cohort [23.8%/11.4% p CONCLUSIONS: "ALS Dashboard" staging changes in the prospectively evaluated cohort was more prominent in the respiratory domain due to changes in standard of practice for these patients. Supported by: Carolinas Healthcare Foundation. Disclosure: Dr. Bravver has received research support from Biogen-Idec Pharmaceuticals, Avanir Pharmaceuticals, Cytokinetics Pharmaceuticals, Neuraltus Pharmaceuticals, Glaxo-Smith Kline Pharmaceuticals, NINDS Clinical Research Consortium. Dr. Sanjak has nothing to disclose. Dr. Brooks has received personal compensation for activities with Biogen Idec, Avanir Pharmaceuticals, Acorda Therapeutics, Cytokinetics, Synapse, and the National Institute of Neurological Disorders and Stroke. Dr. Brooks has received research support from Biogen Idec, Avanir Pharmaceuticals, Cytokinetics, Neuraltus, GlaxoSmithKline, Inc., and the National Institute of Neurological Disorders and Stroke.
Designing Cloaks and Absorbing Blankets for Scattering Reduction Using Field and Impedance Transformation Techniques

In this chapter we present an alternative approach to Transformation Optics (TO) for scattering reduction from radar targets and similar scatterers. The approach is based on Field or Impedance Transformation, as opposed to geometry transformation, which is the heart of the TO algorithm.
Diabetic Retinopathy, Dilated Eye Examination, and Eye Care Education Among African Americans, 1997 and 2004

Objective To examine diabetic retinopathy, dilated eye examination, and eye care education among African Americans before and after a community-level public health intervention. Methods We analyzed data from Project DIRECT (Diabetes Interventions Reaching and Educating Communities Together) participants with self-reported diabetes (617 in 1996-1997 and 672 in 2003-2004) in Raleigh (intervention community) and Greensboro (comparison community), North Carolina. All analyses were weighted to adjust for the complex sample design of pre and post cross-sectional surveys. Estimates were age standardized to the 2000 US Census population. We used multivariate logistic regression to calculate odds ratios and corresponding 95% confidence intervals. Results We found no significant difference in prevalence of diabetic retinopathy between the control and intervention communities ( p > .05). However, after adjusting for other confounders, receipt of eye care education (OR, 1.59; 95% CI, 1.19-2.13) was independently associated with receipt of dilated eye examination among African Americans with diabetes. Compared with individuals without diabetic retinopathy, those with diabetic retinopathy were more likely to use eye care services (OR, 1.89; 95% CI, 1.41-2.54). Conclusions Diabetic retinopathy is a considerable problem among African American communities. Community intervention efforts, such as comprehensive eye care education, that specifically target improvement in diabetic retinopathy and use of eye care services could help better serve this population.
Case Report: Aplastic Anemia with Platelet Thrombi

1. A case of aplastic anemia with platelet thrombi is presented. 2. The developmental features of this anemia are stressed and comparisons made with thrombotic thrombocytopenic purpura. 3. The role of platelet thrombi in other conditions are briefly reviewed.
Changes in Diverse Sexual and Contraceptive Behaviors Across College

Researchers have made repeated calls for a better understanding of normative sexuality development during adolescence and young adulthood. We examined how the occurrence of seven penetrative, nonpe...
Assessing the Impact of Body Mass Index Information on the Performance of Risk Adjustment Models in Predicting Health Care Costs and Utilization

Background:Using electronic health records (EHRs) for population risk stratification has gained attention in recent years. Compared with insurance claims, EHRs offer novel data types (eg, vital signs) that can potentially improve population-based predictive models of cost and utilization.Objective:T
From Association to Foundation

When the basis for AO’s growth was laid in the early 1960s with the creation of the Synthes AG Chur, and the institutionalizing of development through the AOTK, the levers of control were in the hands of just four surgeons—Muller, Schneider, Allgower, and Willenegger. They were all shareholders in Synthes AG Chur, the vessel built to collect the royalties from the three producers and to further fund and develop the AO. The allocation of funds from these collected fees remained in the hands of these four surgeons for most of the AO’s early years.
Using self-determination theory to identify organizational interventions to support coal mineworkers’ dust-reducing practices

Abstract Advancing the application of safety and health (S&H) technologies is likely to remain a value in the mining industry. However, any information that technologies generate must be translated from the organization to the workforce in a targeted way to result in sustainable change. Using a case study approach with continuous personal dust monitors (CPDMs), this paper argues for an organizational focus on technology integration. Although CPDMs provide mineworkers with near real-time feedback about their respirable coal dust exposure, they do not ensure that workers or the organization will continuously use the information to learn about and reduce exposure sources. This study used self-determination theory (SDT) to help three mines manage and communicate about information learned from the CPDM technology. Specifically, 35 mineworkers participated in two mixed-method data collection efforts to discuss why they do or do not use CPDMs to engage in dust-reducing practices. Subsequently, the data was analyzed to better understand how organizations can improve the integration of technology through their management systems. Results indicate that using the CPDM to reduce sources of dust exposure is consistent with mineworkers’ self-values to protect their health and not necessarily because of compliance to a manager or mine.
Perceptions of the LGBTQ College Campus Climate Scale: Development and Psychometric Evaluation

This article reports the development and psychometric properties of scores on a new scale designed to assess views of the university/college campus climate concerning LGBTQ students and issues: Perceptions of the LGBTQ College Campus Climate Scale. This 6-item scale includes two subscales: College Response to LGBTQ Students and LGBTQ Stigma. We provide evidence for structural validity (via exploratory and confirmatory factor analyses) and reliability for scores on this new measure. Supporting construct validity, Perceptions of the LGBTQ College Campus Climate full scale and subscales were each positively correlated with experiences of LGBTQ victimization on campus, anxiety, and depression and negatively correlated with satisfaction with college and intention to persist in college. Relationships with mental health and academic outcomes held true, even after controlling for LGBTQ victimization experiences, providing support for incremental validity. Implications for future research and practice are discussed.
Two Philosophical Approaches to the Problem of Technics and Their Meaning for Latin America

The first difficulty one encounters when thinking about technics concerns whether it is singular or plural. Technics manifests itself today in the guise of many technics, as an irreducible plural reality, which argues against any hypostatizing of the phenomenon by talking about it with a reductionist singularity. Technics are not always some one technique. There are always many technics in the form of radically diverse manifestations that are impossible to unify in some global definition that takes account of this complexity.
Leptin-induced Trafficking of KATP Channels: A Mechanism to Regulate Pancreatic β-cell Excitability and Insulin Secretion

The adipocyte hormone leptin was first recognized for its actions in the central nervous system to regulate energy homeostasis but has since been shown to have direct actions on peripheral tissues. In pancreatic β-cells leptin suppresses insulin secretion by increasing KATP channel conductance, which causes membrane hyperpolarization and renders β-cells electrically silent. However, the mechanism by which leptin increases KATP channel conductance had remained unresolved for many years following the initial observation. Recent studies have revealed that leptin increases surface abundance of KATP channels by promoting channel trafficking to the β-cell membrane. Thus, KATP channel trafficking regulation has emerged as a mechanism by which leptin increases KATP channel conductance to regulate β-cell electrical activity and insulin secretion. This review will discuss the leptin signaling pathway that underlies KATP channel trafficking regulation in β-cells.
A Critical Review of Help-Seeking for Couples Therapy: Clinical Implications and Next Steps

Research has linked relationship distress and divorce to negative mental and physical health outcomes. However, couples seem reluctant to engage in couples therapy. One aim of couple help-seeking is to better understand the process involved in getting couples into therapy. The goal of this type of literature this is to increase participation in couples therapy. To achieve this goal, a critical understanding of the current literature on help-seeking for couples therapy is needed. This paper reviews that literature, evaluating methodologies and theories used, and discuss research and clinical implications. We hope researchers can use this article as a springboard for future projects and that clinicians can apply the findings and implications in their practices.
Transhuman, posthuman and complex humanness in the 21st century

Summary Bodies are hacked to exceed natural physical human limits, which is a sine qua non of the world view of transhumanism. According to transhumanists, death is unnecessary, and medicine undermines radically evolving humans beyond unrealized levels. To body hackers and biohackers, there is no need to wait to explore the innovations that conventional medicine acts exiguously in combatting. The goal of the transhumanist movement is to go beyond current human, to become posthuman. Unbound potential and existential risks of life expansion and radical modifications are inflection points of a new world. I propose looking at ethics from a calculus of iterative complexity to understand a dynamic scientific movement that is unchartered. Evolution of the human of the 21st century is at the mercy of novel, radical technology. Contested arguments around superwellness and superlongevity are certain to follow the revolution. The cascading effects of posthumanism and transhumanism on the body will unavoidably impinge on us all.
Mapping lesbian and queer lines of desire: Constellations of queer urban space:

The path to lesbian, gay, bisexual, transgender, and queer (LGBTQ) liberation has been narrated through a claim to long-term, propertied territory in the form of urban neighborhoods and bars. Howev...
COMe-SEE: Cross-modality Semantic Embedding Ensemble for Generalized Zero-Shot Diagnosis of Chest Radiographs

Zero-shot learning, in spite of its recent popularity, remains an unexplored area for medical image analysis. We introduce a first-of-its-kind generalized zero-shot learning (GZSL) framework that utilizes information from two different imaging modalities (CT and x-ray) for the diagnosis of chest radiographs. Our model makes use of CT radiology reports to create a semantic space consisting of signatures corresponding to different chest diseases and conditions. We introduce a CrOss-Modality Semantic Embedding Ensemble (COMe-SEE) for zero-shot diagnosis of chest x-rays by relating an input x-ray to a signature in the semantic space. The ensemble, designed using a novel semantic saliency preserving autoencoder, utilizes the visual and the semantic saliency to facilitate GZSL. The use of an ensemble not only helps in dealing with noise but also makes our model useful across different datasets. Experiments on two publicly available datasets show that the proposed model can be trained using one dataset and still be applied to data from another source for zero-shot diagnosis of chest x-rays.
Radical Moderns/Poetry International: Communist Poets in the 1930s

This chapter focuses on an international circle of communist poets active during the long 1930s: Nâzim Hikmet (Turkey), Pablo Neruda (Chile), Muriel Rukeyser and Langston Hughes (USA), and Yannis Ritsos (Greece). Described variously as “poetry international” (Aijaz Ahmad) and “radical moderns” (Michael Denning), these poets represent a distinctive moment for left-wing aesthetics and internationalist solidarity. This chapter discusses the common events and experiences that appear across their poems (especially the Spanish Civil War). It analyzes the twin themes of love (as a form of solidarity across distance) and “the people” (the creation of a usable national past). These make up a “1930s structure of feeling,” which the chapter compares with the dominant aesthetic modes, sensibility, and genres of the present day. The chapter discusses the contemporary prospects for a global cultural movement resisting populism and authoritarianism, arguing that the poetry of the 1930s may inspire but cannot serve as the basis for the poetry of today.
SPORT MATTERS: On Art, Social Artifice, and the Rules of the Game, or, the Politics of Sport

This essay will explore three interrelated topics. First, I will examine the moral implications of viewing sport as an example of social artifice, that is, arbitrary norm-and-boundary-creation which makes certain complex social rituals possible. Second, I will examine the history of the Modern Olympic Revival as an example of Neohellenism, one which emphasized the moral and pedagogical meaning of such athletic artifice. This will set the stage for the third and longest portion of the essay, a discussion of what is arguably the finest book on the moral and political meaning of organized sport ever written, C. L. R. James’s Beyond a Boundary.
A Novel Assessment Using Projected Transmitral Gradient Improves Diagnostic Yield of Doppler Hemodynamics in Rheumatic and Calcific Mitral Stenosis.

Abstract Objectives The aims of this study were to: 1) develop a formula for projected transmitral gradient (TMG), expected gradient under normal heart rate (HR), and stroke volume (SV); and 2) assess the prognostic value of projected TMG. Background In mitral stenosis (MS), TMG is highly dependent on hemodynamics, often leading to discordance between TMG and mitral valve area. Methods All patients with suspected MS based on echocardiography from 2001 to 2017 were analyzed. Data were randomly split (2:1); projected TMG was modeled in the derivation cohort, then tested in the validation cohort. The composite endpoint was death or mitral valve intervention. Results Of 4,973 patients with suspected MS, severe and moderate MS, defined as mitral valve area ≤1.5 and >1.5 to 2.0 cm2, were present in 437 (9%) and 936 (19%), respectively. In the derivation cohort (n = 3,315; age 73 ± 12 years; 34% male), corresponding gradients were TMG ≥6 and 4 to Conclusions The novel concept of projected TMG, constructed using the observed impact of HR and SV on TMG, significantly improved the concordance of gradient and valve area in MS and provided better risk stratification than TMG.
Myocardial Infarction with Nonobstructive Coronary Artery Disease—Definition, Etiopathogenesis, Diagnosis, and Management

Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a complex clinical syndrome that is characterized by evidence of acute myocardial infarction in the absence of significant epicardial coronary artery disease on angiography. The term “MINOCA” encompasses a group of heterogeneous diseases with varying underlying mechanisms and each with its own pathophysiology. Overlooked plaque rupture or erosion and coronary vasospasm are the most common causes of MINOCA and can be diagnosed by routine intracoronary imaging and vasoreactivity testing, respectively. Coronary microvascular dysfunction is a less recognized, albeit an important cause of morbidity in patients presenting with MINOCA. Although MINOCA is a rare presentation of acute coronary syndrome, it is not a benign disorder and can have adverse consequences if untreated. In this article, we aim to review the pathogenesis, clinical characteristics, and finally propose a systematic approach in the diagnosis and management of patients with MINOCA.
Comment on "Direct observation of excitonic instability in Ta$_2$NiSe$_5$" [arXiv:2007.08212 (2020)]

The origin of the second order phase transition at 328K in Ta$_2$NiSe$_5$, a prominent candidate for direct gap excitonic insulator, remains under fervent debate. The driving force for the transition can be revealed by identification of the soft mode's origin that may be deducted from polarization resolved Raman scattering experiments. Such studies were recently reported in [arXiv:2007.07344 (2020)], [arXiv:2102.07912 (2021)], [arXiv:2007.01723 (2020)] and [arXiv:2007.08212 (2020)]. In this Comment, it is shown that the parameters derived in a recent arXiv by Kwangrae Kim et. al. [arXiv:2007.08212 (2020)], including the Weiss temperature for excitonic transition, are based on inconsistent data.
Indigenous Technology Standards for Development: The Case of China

Research since the 1980s has considered the economic and innovation impacts of technology standards policies. This paper extends the research on the impact of standardization policies to consider how the policies themselves, governing how the standards are created, determine standards’ impact on emerging economies’ economic performance and innovation capabilities. Using four cases of digital technology standardization in China, this paper finds that combinations of government financial and market support and openness to domestic and foreign contributors determines how and when digital standardization begets positive technological and economic impacts for firms. This paper contributes to our understanding of international technology upgrading in emerging economies, as well as suggesting policies for successful economic upgrading in large emerging economies.
GORHAM-STOUT DISEASE IN THE MANDIBLE: A CASE REPORT

Introduction Gorham-Stout disease is a rare disease that was first described by Jackson in 1838. The first case in jaws was reported in 1924. There is no clear consensus on the etiopathogenesis of the disease. A few proposed theories include bone destruction secondary to hyperemia from hemangiomatosis, increased osteoclastic activity mediated by IL-6, and lymphangiogenesis mediated by vascular endothelial growth factor, platelet-derived growth factor, and IL-6. The disease presents as an osteolytic lesion without cortical expansion. Here, we present a case of Gorham-Stout disease exhibiting hemorrhagic gingival overgrowth in the mandible. Case Report A 46-year-old female patient presented with a chief complaint of blisters and bubbles in her lower gums. Clinical examination revealed multiple loose teeth in the anterior and left mandible with hemorrhagic and hyperplastic gingival tissue. Upon radiographic evaluation, significant bone loss was recognized in the area, giving the appearance of “teeth floating in air.” The differential diagnosis included Gorham-Stout disease, osteomyelitis, Langerhans cell histiocytosis, and other conditions with osteolytic changes. Histologic examination of the biopsy specimen revealed atypical vascular proliferation with mixed acute and chronic inflammation favoring exuberant granulation tissue. Her lab workup confirmed elevated levels of serum IL-6 and vascular endothelial growth factor. A diagnosis of Gorham-Stout disease was made based on these findings. The patient presented with a pathologic fracture of her left mandible 3 months after her initial consultation. She was referred to rheumatology and treatment with bisphosphonates was initiated. However, the patient failed to return for further treatment with the physician and was lost to follow-up.
Increased Odds of Incident Alzheimer's Disease and Related Dementias in Presence of Common Non-Cancer Chronic Pain Conditions in Appalachian Older Adults.

BackgroundThere is a growing concern regarding the increasing prevalence of common non-cancer chronic pain conditions (NCPCs) and their possible association with Alzheimer’s disease and related dem...
Ureteral reconstruction for complex strictures: a review of the current literature

Frequently employed procedures for ureteral reconstruction include balloon dilation, pyeloplasty and ureteral re-implants. However, these procedures do not work for complex ureteral disease. The goal of this literature review is to report on techniques and success rates for the following techniques: buccal graft ureteroplasty, appendiceal interposition, transureteroureterostomy, ileal ureter and autotransplantation. A comprehensive literature search for English-language original and review articles was conducted using PubMed. The following terms were queried: “ureteral reconstruction”, “buccal graft”, “appendiceal interposition”, “ileal ureter”, “transureteroureterostomy”, “autotransplantation”. Procedures involving the buccal mucosa or appendix offer minimally invasive techniques and low morbidity with good short-term success. Drawbacks to appendiceal interposition include the availability and length of appendix, and 10–20% of patients may have insufficient appendix upon intra-operative assessment. Transureteroureterostomy is typically limited to extensive exonerations due to concerns of injury to the contralateral kidney, even with reported success rates > 90%. Ileal ureter may carry a risk of metabolic acidosis in patients with renal insufficiency along with bowel-related complications. Ileal ureter and autotransplantation are reserved for the most severe cases due to their high morbidity but do offer options for the complex patient. Ureteral stricture disease not amenable to pyeloplasty, ureteroureterostomy or ureteroneocystostomy offers a challenge to urologist. Careful patient selection with pre-operative assessment of renal and bladder is vital to a successful operation with minimal complications.
Factors associated with intention to engage in self-protective behavior: The case of over-the-counter acetaminophen products.

Abstract Background Inappropriate use of acetaminophen products is a concern due to the severe liver damage associated with intentional or accidental overdose of these products. In 2009, the U.S. Food and Drug Administration (FDA) issued more severe organ-specific warnings for the acetaminophen Drug Facts label to improve protective behavior among patients. However, it is not clear how patients react to such interventions by the FDA. Objective The objective of this study was to evaluate the factors influencing patients' intention to engage in protective behavior while using acetaminophen products after reading the Drug Facts label. The study specifically looked at the relationship between four Protection Motivation Theory-based risk cognition factors and the intention to engage in protective behavior. Methods An experimental, cross-sectional, field study was conducted using self-administered questionnaires at four community pharmacies in Houston, TX. Two hundred surveys were collected from adults visiting the selected pharmacy stores. Participants were exposed to a simulated label (i.e. Drug Facts label) containing organ-specific warnings for over-the-counter (OTC) acetaminophen products. Risk cognition measures (i.e. measures of perceived severity, perceived vulnerability, response efficacy, and self-efficacy) and measures of intention to engage in protective behavior (always reading warnings, using products with more caution, and consulting a pharmacist/physician) were recorded. Pearson correlation and multiple linear regression analyses, controlling for demographic and behavioral characteristics of the participants, were performed. Results Bivariate analyses indicated that an increase in perceived severity, perceived vulnerability and response efficacy were associated with a higher intention to engage in protective behavior. Findings from the multiple regression indicated that increase in perceived severity of liver damage, belonging to a non-healthcare occupation, no history of acetaminophen use and no history of alcohol consumption were associated with a higher intention to engage in protective behavior. Conclusion Higher risk cognition of liver damage associated with inappropriate use of OTC acetaminophen products leads to greater intention to engage in protective behavior while using such products. Developing interventions targeted towards improving reading and adhering to the Drug Facts label could improve risk cognition, and thus improve patients' intention to engage in protective behavior. Regular acetaminophen users, heavy alcohol consumers and healthcare professionals might need other interventions apart from the Drug Facts label to improve their likelihood to engage in protective behavior.
Impact of providing milk options and nutrient information in school lunch programs

Results of this study suggest that there is considerable demand for a choice of milk in school lunch programs.
Recipe for disaster: professional and patient equally sharing responsibility for developing psychiatric diagnosis.

Fulford et al are, of course, correct in asserting that psychiatric diagnosis involves not only facts, but values. They are also correct in emphasizing the stake that patients - and the community - have in how psychiatric diagnosis is developed and applied. No one can doubt that, for example, certain terms that have been used in psychiatric classification, such as "psychopath" and "addict", have had a stigmatizing effect. It is partly for these reasons that such terms have been avoided in more recent psychiatric classifications. However, Fulford et al have not provided the reader with examples from the current DSM in which the classification would have been better, had more attention been given to examining the implicit values of various diagnoses or the way in which diagnostic criteria were formulated.