cssi/SciSciGPT-SciSciNet huggingface dataset:
Dual-modality single particle orientation and rotational tracking of intracellular transport of nanocargos.

The single particle orientation and rotational tracking (SPORT) technique was introduced recently to follow the rotational motion of plasmonic gold nanorod under a differential interference contrast (DIC) microscope. In biological studies, however, cellular activities usually involve a multiplicity of molecules; thus, tracking the motion of a single molecule/object is insufficient. Fluorescence-based techniques have long been used to follow the spatial and temporal distributions of biomolecules of interest thanks to the availability of multiplexing fluorescent probes. To know the type and number of molecules and the timing of their involvement in a biological process under investigation by SPORT, we constructed a dual-modality DIC/fluorescence microscope to simultaneously image fluorescently tagged biomolecules and plasmonic nanoprobes in living cells. With the dual-modality SPORT technique, the microtubule-based intracellular transport can be unambiguously identified while the dynamic orientation of nano...
Relative Toxicity of Minor Cotton Terpenoids Compared to Gossypol

The antibiotic activities of 3 compounds that have been described as insecticidal were compared to that of the closely related gossypol. No difference in toxicity was noted. Since gossypol content always was in excess of these substances, they may serve to supplement the activity of gossypol but, in themselves, are only of minor importance.
Mobile Lasercom Systems Using Modulating Retro-reflectors

The use of lasercom on mobile platforms is complicated by the pointing precision required. Modulating retro-reflectors greatly relax pointing requirements, enabling lasercom on a variety of mobile platforms not possible with traditional lasercom.
A Carbohydrate-Lipid Fraction of Gonococcus and Meningococcus

animals and, although protein-free, was antigenic and immunologically specific. Several reports from that laboratory followed, e.g. Boivin and Mesrobeanu (1934, 1935, 1937, 1938), Boivin, Mesrobeanu and Mesrobeanu (1933, 1935) and Boivin, Mesrobeanu, Mesrobeanu and Nestorescu (1934). These investigators regarded the preparation as the somatic antigen and designated it "antigene 'complet, .,, Maccolini (1938) confirmed Boivin's findings on Salmonella aertrycke. Boivin (1940) using trichloracetic acid prepared two toxic antigens from Shigella dysenteriae. One which was a glucolipid,* he called the endotoxin and the other the exotoxin although the latter was isolated from young bacterial cells as well as from a filtrate of liquid culture. Raistrick (1934) and Topley (1937) and collaborators prepared a material similar to Boivin's antigen from Salmonella aertrycke and from Bacterium typhosum by alcohol treatment of a
Expression and localization of Polo-like kinase 2 in osteosarcoma cells

Objective:To construct the expression plasmid of human Polo-like kinase 2(hPlk2) gene and identify the expression and localization of hPlk2 in osteosarcoma MG-63 cells.Methods: Human Plk2 coding sequence was obtained by polymerase chain reaction(PCR) amplification and cloned into 3* Flag vector.After the target region was identified by enzyme digestion and sequencing,the plasmid was transfected into osteosarcoma MG-63 cells.The expression of the recombinant plasmid in MG-63 cells was detected by Western blot.The localization of 3* Flag-hPlk2 in MG-63 cells was observed with laser scanning confocal microscopy.Purify the hPlk2 protein by immunoprecipitation assay.Results: hPlk2 was constructed into the expressing vector 3* Flag successfully.The length of the fragment identified by restriction enzyme digestion was 2058bp.The expression of 3* Flag-hPlk2 fusion protein with a molecular weight of 80kDa was detected by Western blot and pulled down by Flag antibody,and its localization was in the cytoplasm and perinucleus in MG-63 cells.Conclusion: The recombinant plasmid of hPlk2 gene was successfully cloned into eukaryotic expressing vector,and the expression of 3* Flag-hPlk2 fusion protein was identified and pulled down by Flag antibody,expressed in cytoplasm and perinucleus.
A remark on Donovan's conjecture

It is shown that the difference between Donovan’s conjecture and the weaker conjecture bounding Cartan numbers of blocks of finite groups by the defect of the blocks can be expressed in terms of the relationship between pairs of Galois conjugate blocks. A consequence is that for principal blocks the two conjectures are equivalent.
Review: bisphosphonates prevent or delay skeletal events in women with advanced breast cancer and bone metastases.

Source Citation Pavlakis N, Schmidt RL, Stockler M. Bisphosphonates for breast cancer. Cochrane Database Syst Rev. 2005;(3):CD003474. 16034900
Four Explanations of the Political Use of Psychiatry

As noted in the first chapter, many states confront episodic phenomena of widespread political, nationalist, ethnic and religious dissidence, or, like India, face a permanent risk of communal violence and dismemberment because of these social fracture lines. The Soviet experience with a dissident movement, remarkable for its duration, intensity, broad base of recruiting, and significance in the erosion of the Union, is also extraordinary1 because of the state’s response. The authorities have forcibly confined hundreds, possibly thousands, of the more vocal or irritating activists to psychiatric hospitals for extended periods as one coercive reaction to dissenting behaviour. Even pariah states such as South Africa at the height of its defence of apartheid and efforts to control inter-ethnic violence evidently did not resort to systematic psychiatric hospitalization in efforts to inhibit political upheaval in the townships. Perhaps equally inventively and more cost-effectively, the South African authorities did arrest thousands of children under 15, as a disincentive to political activity on the part of their parents and other relatives.
Impact of Sleep-Disordered Breathing Treatment on Patient Reported Outcomes in a Clinic-Based Cohort of Hypertensive Patients.

STUDY OBJECTIVES We hypothesized that patient reported outcomes (PROs) improve with positive airway pressure (PAP) in patients with sleep-disordered breathing (SDB) and hypertension (HTN). METHODS Questionnaire-based PROs (sleepiness [Epworth Sleepiness Scale, (ESS)], depression [Patient Health Questionnaire-9 (PHQ-9)], and fatigue [Fatigue Severity Scale (FSS)]) were retrospectively examined in patients with SDB and HTN at baseline and within a year following PAP initiation. PRO changes were estimated using multivariable linear mixed-effect models adjusted for baseline age, sex, race, body mass index, resistant hypertension (RHTN) status, cardiac and diabetes history, and correlation between repeated measurements. Age and race by PAP interaction terms (mean change, 95% CI) were examined. RESULTS 894 patients with HTN and SDB were examined. 130 (15%) had baseline RHTN (age 58 ± 12 y, 52.9 % male, BMI 36.2 ± 9.1 kg/m2). In multivariable models, a significant improvement in sleepiness ESS (-2.09, 95% CI: -2.37, -1.82), PHQ-9 (-1.91, 95% CI: -2.25, -1.56), and FSS scores (-4.06 95% CI: -4.89, -3.22) was observed. A significant race by PAP effect interaction was observed (p < 0.0001 for all PROs); Caucasians had greater improvements than non-Caucasians. The interaction term of effect of PAP and age was significant for ESS (p = 0.04) and PHQ-9 (p = 0.0003), indicating greater improvement in younger patients. CONCLUSIONS Consistent improvement of broad PRO domains in response to PAP in SDB was observed in this clinic-based hypertensive cohort; Caucasians and younger patients derived greater benefit.
Christopher Alexander’s Nature of Order

Christopher Alexander is an oft-referenced icon for the concept of patterns in programming languages and design [1–3]. Alexander himself set forth his theory of good architectural design and its pursuit via architectural patterns in three books published in the latter half of the 1970s [4–6]. In a follow-up to his three-volume architectural exposition, he published a four-volume treatise on The Nature of Order that extensively examines his underlying theory and philosophy of wholeness and the properties of life in systems [7–10]
Inhibition of Graft-Versus-Host-Disease (GVHD) by Treatment with the Cyclopentenone Prostaglandin 15d-PGJ2 Involves Modulation of the NF-κB Signaling Pathway.

Graft-versus-host disease (GVHD) mediated by alloreactive donor T cells is the most dreaded complication after allogeneic bone marrow transplantation (BMT). Interaction of donor T cells with host antigen presenting cells is considered to be central to the development of GVHD. Furthermore, GVHD development depends on the inflammatory response induced by the conditioning regimen. Interfering with inflammatory signaling pathways could be an approach to prevent GVHD without compromising the graft-versus-malignancy reaction. Peroxisome proliferator-activated receptor-gamma (PPARγ) is a nuclear receptor transcription factor that regulates cell growth, differentiation and homeostasis. PPARγ agonists, such as 15-deoxy -Δ12,14-Prostaglandin J2 (15d-PGJ2) have been shown to have potent immunomodulatory effects on B and T lymphocytes as well as DCs, and recent studies have demonstrated protective effects of PPARγ agonists on animal models of autoimmunity including experimental allergic encephalomyelitis (EAE), asthma, arthritis, colitis and diabetes. There is very few data addressing the role of PPARγ agonists on GVHD. The aim of this study was to investigate the protective effect and mechanism of 15d-PGJ2 on experimental GVHD. GVHD was induced following lethal irradiation (1075 rad) using the fully MHC-mismatched strain combination BALB/c to B6. Recipients were treated with 1 mg/kg of 15d-PGJ2 i.p on days −1, +1, +3, +5 and +7 post-BMT. Treatment with 15d-PGJ2 resulted in a significantly reduced GVHD mortality (p=0.01 log rank test) with a Median Survival Time (MST) of 23 days in the control group. Median survival was not reached in the 15d-PGJ2 treatment group at the end of the observation period (day +50 post BMT). Furthermore, we found a significant reduction in donor T cell expansion of 15d-PGJ2-treated animals on day +6 post-BMT. To further delineate the mechanisms underlying its protective effect, we analyzed the effects of 15d-PGJ2 on alloantigen-driven proliferation in MLR cultures in vitro as well as development and maturation of mouse bone marrow derived- dendritic cells (DC) in vitro. Treatment with 15d-PGJ2 resulted in a dose-dependent inhibition of allo-antigen driven proliferation. Furthermore, using a 12-day culture system 15d-PGJ2 led to a significant reduction of mature DC as determined by the number of DC co-expressing CD40, CD80, CD86. Treatment for 24 hours with 5uM of 15d-PGJ2 significantly inhibited activation of the NF-κB pathway as demonstrated by abrogation of p65 and IkB-α phosphorylation in response to alloactivation and also in 15d-PGJ2 treated DC using western blot analysis. In conclusion our data support the notion that the inhibitory effect of 15d-PGJ2 on the development of GVHD involves NF-κB-dependent inhibition of DC maturation and expansion of donor T cells. Given its potent antitumor effects cyclopentenone prostaglandins could be ideal candidates for prevention of GVHD while maintaining Graft versus malignancy effects.
Catalytic Valorization of Lignin Using Niobium Oxide

There is a significant interest in valorization of lignin into chemicals. In this research, niobium oxide was tested as a catalyst for partial oxidation of lignin. Research objectives were to: (1) study the effect of temperature and catalyst loading on synthesis of aromatics from lignin, (2) study the effect of oxidants and rate of mixing on lignin oxidation, and (3) determine the reaction kinetics. Batch experiments were performed via a factorial design with catalyst loading (0.1–0.3 g) and temperature (70–90 °C) as factors. Results indicated that under optimal conditions of temperature of 90 °C, and catalyst loading of 0.5 g, 137.194 mg L−1 of vanillin and 30.290 mg L−1 of acetovanillone were produced. Oxidant type was found have a significant effect for vanillin production but not for acetovanillone. In addition, production of both vanillin and acetovanillone were independent of mixing. It is theorized that formation of aceto derivatives and vanillin under alkaline conditions were due to retroaldol cleavage of the α-hydroxy-γ-carbonyl structure of the lignin.
Do Antiplatelet and Anticoagulation Agents Matter after Repair of Traumatic Arterial Injuries

Thrombosis is a devastating complication after repair of traumatic vascular injury. Although thrombosis rates have been described, the value of anticoagulation in preventing postrepair thrombosis is unknown. We hypothesize that postoperative anticoagulation reduces thrombosis rates. A total of 1524 consecutive patients with traumatic arterial injuries from January 2005 to June 2015 were identified, and 381 patients underwent the following repair types: direct suture of vessel wall, primary anastomosis, extra-anatomic reconstruction, tissue and synthetic interposition reconstruction. Twenty six patients received postoperative heparin at therapeutic levels, and 29 patients received postoperative aspirin for five consecutive days. The heparin and aspirin groups were matched with patients without postoperative anticoagulation by the following variables: anatomic arterial injury, type of vascular repair, and age. These groups were then compared using the following outcome measures: mortality, thrombosis of repaired vessel, amputation, hemorrhage, cerebral vascular accident, and extremity compartment syndrome. The demographics between the heparin, aspirin, and respectively matched groups were not statistically different. There was no statistically significant difference in the rate of thrombosis, bleeding, compartment syndrome, cerebral vascular accident, limb amputation, or mortality. Although there was no increase in bleeding complications with the use of heparin or aspirin, there was also no impact on the rate of thrombosis.
Evaluation of Inhibitors for Rapid Enumeration of Psychrotrophic Bacteria

Two inhibitors of the 17 tested inhibited growth of gram positive bacteria without causing inhibition of gram negative bacteria. These were crystal violet at 2 mg/1 and neotetrazolium chloride at 2 mg/1. In addition, basic fuchsin at 6 mg/1 produced only marginal reduction in counts of gram negative bacteria. These inhibitors might find further use in developing a test for psychrotrophic bacteria in the presence of non-psychrotrophic bacteria.
Depletion of Sorbate from Different Media During Growth of Penicillium Species.

Penicillium cyclopium , Penicillium roqueforti , Penicillium viridicatum , Penicillium puberulum , Penicillium cyclopium (atypical strain), Penicillium crustosum and Penicillium lanoso-viride were isolated from spoiled cheese. These molds grew and depleted sorbate from media when the chemical was present initially at a concentration of up to 3,000, 10,000, 6,000, 12,000, 12,000, 7,000 and 3,000 ppm, respectively. A combination of paper chromatography and spectrophotometry was used to determine amounts of residual sorbate. Seventy-one to 100% of sorbate present initially was depleted from media by the various molds during 4-20 days of incubation at 21°C and 22-48 days at 4°C. The substrate influenced growth of mold and depletion of sorbate, but uniform behavior was not observed for all the Penicillium species studied. For example, presence of 3,000 ppm of sorbate plus 1% casein in the medium inhibited P. cyclopium and P. lanoso-viride but not the other five species. Concentration of sorbate (3,000 - 9,000 ppm) plus temperature (4, 12, 21 °C) were important for inhibitory action of the preservative on P. cyclopium , P. viridicatum , P. crustosum and P. lanoso-viride but not P. puberulum , P. cyclopium (atypical strain) which grew at 4 °C and depleted sorbate when the initial concentration was up to 9,000 ppm and P. roqueforti which grew at up to 6,000 ppm at the same temperature.
The implantable loop recorder and its mammographic appearance: A case based approach

The normal radiographic appearance of implantable loop recorders has been illustrated in the radiology literature; however, their mammographic appearance has not been described. Breast imagers should become familiar with the appearance of loop recorders in order to create an accurate report. In this paper we report 3 cases of patients with implantable loop recorders who underwent mammography. We describe the types and components of implantable loop recorders, indications for their placement, and their classic appearance on mammography.
LCST–UCST-Based Copolymerizations

It was shown in Chap. 3 that a polymerization system can start as a conventional precipitation system and end as an FRRPP system, especially if the phase diagram exhibits an hourglass-shaped phase envelope at relatively high polymer molecular weight. This sets up the arguments for other types of shifts from UCST- and LCST-based chain polymerizations, especially in cases wherein multiple monomers are involved. The analysis here will be made for two monomers (copolymerizations), but can be easily extended to multiple monomers. Operationally, it should be emphasized that this is basically a one-pot polymerization methodology, which can be extended to semibatch reactant introduction into the reactor.
Structural Family Therapy and Autism Spectrum Disorder: Bridging the Disciplinary Divide

ABSTRACTApplied Behavior Analysis (ABA) is an evidence-based practice approach for the treatment of individuals with autism. The systemic effects of autism suggest that family therapy would considerably enhance the treatment of individuals with autism. Marriage and family therapy (MFT) training does not routinely include exposure to autism beyond the associated diagnostic criteria. Structural Family Therapy (SFT) is a systemic model that is familiar to those trained in family therapy and appropriate for the needs of families affected by autism. Therefore, the authors have used SFT as a foundation for supervising MFT trainees working in an autism treatment setting.
Interactions of a Low-Aspect-Ratio Cantilevered Dynamic Pin with a Boundary Layer

The interaction of a low-aspect-ratio finite-span pin with a laminar flow over a flat plate was investigated experimentally. The pin was either static or dynamically oscillated in the wall-normal d...
Growth Hormone Action on Adipocytes

Adipose tissue appears to be one of the physiologically important targets for direct actions of growth hormone. Many of the metabolic responses to growth hormone that can be elicited in appropriately prepared experimental animals in vivo can also be shown in vitro when physiologically relevant concentrations of growth hormone are added to segments of epididymal fat or isolated fat cells. Metabolic responses to growth hormone, which are demonstrable either in vivo or in vitro, however, are complex and time-dependent. The initial responses are insulinlike, but these are short-lived and within a few hours give way to the more typical counterinsulin responses that are generally recognized as the physiological consequences of chronic treatment with growth hormone.(1,2)
Wakefield in solid state plasma with the ionic lattice force

The advent of the path to a single cycle X-ray laser pulse via thin film compression and the relativistic compression enables laser wakefield acceleration in solid materials. We study the collective interaction of the X-ray laser pulse with the solid-state plasma, including ultrafast polariton effects, giving rise to TeV/cm wakefields with highly increased critical density. Our particle-in-cell computational analysis delineates wakefield effects and polariton dynamics. We show that a good quality wakefield can be excited even in the presence of the lattice force and the electron acceleration process is not influenced by polaritons. The applications and implications of the ultrafast wakefield and ultrafast plasmonics are discussed.
Understanding the Correlation Between DSA, Complement Activation, and Antibody-Mediated Rejection in Heart Transplant Recipients.

BACKGROUND Donor-specific HLA antibodies (DSA) are associated with increased rates of rejection and of graft failure in cardiac transplantation. The goal of this study was to determine the association of preformed and posttransplant development of newly detected DSA (ndDSA) with antibody-mediated rejection (AMR) and characterize the clinical relevance of complement-activating DSA in heart allograft recipients. METHODS The study included 128 adult and 48 pediatric heart transplant patients transplanted between 2010 and 2013. Routine posttransplant HLA antibody testing was performed by IgG single-antigen bead test. The C3d single-antigen bead assay was used to identify complement-activating antibodies. Rejection was diagnosed using International Society for Heart and Lung Transplantation criteria. RESULTS In this study, 22 patients were transplanted with preexisting DSA, and 43 patients developed ndDSA posttransplant. Pretransplant (P < 0.05) and posttransplant (P < 0.001) ndDSA were associated with higher incidence of AMR. Patients with C3d + DSA had significantly higher incidence of AMR compared with patients with no DSA (P < 0.001) or patients with C3d-DSA (P = 0.02). Nine (36%) of 25 patients with AMR developed transplant coronary artery disease compared with 17 (15.9%) of 107 patients without AMR (P < 0.05). Among the 47 patients who received ventricular assistant device (VAD), 7 of 9 VAD+ patients with preformed DSA experienced AMR compared with 7 of 38 VAD+ patients without preformed DSA, indicating presensitization to donor HLA significantly increased the risk of AMR (P < 0.01). CONCLUSIONS Preformed and posttransplant ndDSA were associated with AMR. C3d + DSA correlates with complement deposition on the graft and higher risk of AMR which may permit the application of personalized immunotherapy targeting the complement pathway.
Analyzing the Structure of Test Data

One of the common uses of MIRT is the analysis of the structure of the item response data that results from the administration of a set of test items to a sample of examinees. This type of analysis can be done in either an exploratory or confirmatory way. The exploratory analysis of item response data is used when either there is no clear hypothesis for the structure of the item response data, or when an unconstrained solution is seen as a strong test of the hypothesized structure. Confirmatory analyses require a clear hypothesis for the structure of the item response data. That is, there must be hypotheses about the number of coordinate dimensions needed to model the data and the relationship of the item characteristic surface to the coordinate axes. The types of confirmatory analyses that are typically done specify the relationship of the direction best measured by a test item (the direction of maximum discrimination) with the coordinate axes. It is also possible to have hypotheses about the difficulty of test items, but such hypotheses are seldom checked with the MIRT models. The difficulty parameters are typically left as parameters to be estimated without constraints.
Principles of Optical Radiometry and Measurement Uncertainty

Abstract The fundamental concepts of optical radiometry are developed from basic principles, with detailed explanations for radiance, irradiance, and reflectance. Examples of radiometric standards, in particular radiometers and reference sources, are given, and the methods of realization of spectral radiance, spectral irradiance, or spectral reflectance are described. The concept of the measurement equation is introduced and applied to methods of estimating uncertainty for measurement results. Examples of this approach are given, using a filter radiometer and lamp standards of spectral irradiance as a demonstration. The terminology and recommended protocols presented here are based on international bodies such as the International Organization for Standardization, the International Commission on Illumination, and the Bureau International des Poids et Mesures (BIPM).
Data Distillation at the Network's Edge: Exposing Programmable Logic with InLocus

With proliferating sensor networks and Internet of Things-scale devices, networks are increasingly diverse and heterogeneous. To enable the most efficient use of network bandwidth with the lowest possible latency, we propose InLocus, a stream-oriented architecture situated at (or near) the network's edge which balances hardware-accelerated performance with the flexibility of asynchronous software-based control. In this paper we utilize a flexible platform (Xilinx Zynq SoC) to compare microbenchmarks of several InLocus implementations: naive JavaScript, Handwritten C, and High-Level Synthesis (HLS) in programmable hardware.
Measuring the Influence of Physiological Noise Corrections on ICA Derived Intrinsic Connectivity Brain Networks in Rest and Task fMRI

Physiological noise corrections using RETROICOR algorithm has been shown to increase signal sensitivity in resting state networks such as the default-mode network. However, independent component analysis (ICA)-based network approach may suffer from such corrections especially if there is any overlap between two sources in the decomposition domain. To address the extent the physiological noise corrections may impact ICA derived intrinsic connectivity brain networks, we measured network features including functional network connectivity (FNC), power spectra, and network spatial maps in the resting state and task functional magnetic resonance imaging (fMRI) data that were acquired in the same visit from a group of healthy volunteers. Statistical analysis showed functional connectivity between several networks were significantly changed after RETROICOR corrections in both rest and task fMRI. Significant FNC alterations were found in the subcortical, basal ganglia, salience, and default-mode networks. Power spectra analysis showed a trend toward lower power spectra in the subcortical and salience networks at [0.20 and 0.24] Hz after RETROICOR corrections in both rest and task fMRI. Furthermore, physiological noise corrections led to volumetric decrease in the resting state networks that included the subcortical, basal ganglia, salience, and default-mode networks, and volumetric enlargement in the sensorimotor and cerebellar networks. In task fMRI data, physiological noise corrections generally resulted in the expansion of networks except for task-activated networks including the anterior salience, central executive, dorsal attention, and cerebellar networks. If confirmed with larger sample sizes, these results suggest that physiological noise corrections alter some network features, and that such alterations are different between resting state and task fMRI data.
10-Year Epidemiology of Ankle Injuries in Men’s and Women’s Collegiate Basketball:

Background Ankle injury is the most common injury in men's and women's basketball, regardless of the level of competition. Purpose To use the National Collegiate Athletic Association (NCAA) Injury Surveillance Program/System (ISP/ISS) to review the 10-year epidemiology of ankle injuries in men's and women's collegiate basketball players. Study design Descriptive epidemiology study. Methods The NCAA ISP was queried for men's and women's collegiate basketball ankle injury data from the 2004 through 2014 academic years. Ankle injury rates were calculated based on injuries per athlete-exposure (AE). Injury proportion ratios (IPRs) were determined by comparing variables between sexes. Activity and position of injury were also studied. Results Over the 10-year study period, most ankle injuries in collegiate basketball occurred in the preseason (female, 1.45/1000 AEs; male, 2.00/1000 AEs), were contact related (female, 50.4%; male, 57.6%), were treated conservatively (female, 98.5%; male, 99.3%), and were new injuries (female, 78.0%; male, 78.9%), resulting in a time loss of less than 7 days (female, 62.7%; male, 65.2%). The most common injury types were lateral ligament complex tears (female, 83.5%; male, 80.0%), deltoid ligament tears (female, 5.6%; male, 7.2%), and high ankle sprains (female, 7.1%; male, 7.0%). Guards experienced the highest rate of ankle injuries in competition (female, 50.1%; male, 43.3%), and rebounding was found to be the most common activity during an injury (female, 30.3%; male, 34.4%). The rate of ankle injuries was significantly lower in women than in men (IPR, 0.81 [95% CI, 0.75-0.88]). Conclusion This study found that most ankle injuries in collegiate basketball occurred during the preseason, were contact related, were treated conservatively, and were new injuries that resulted in a time loss of less than 7 days.
"Reduction mammaplasty with superomedial pedicle technique: A literature review and retrospective analysis of 938 consecutive breast reductions".

Summary Background The superomedial pedicle reduction mammaplasty has been noted in the literature to provide superior aesthetic results and longevity as well as shorter operative times. However, the inferior pedicle continues to be the most commonly utilized technique in the United States. There is a lack of large-volume outcome studies examining how the superomedial pedicle technique compares against more established reduction methods. Methods A retrospective review of 938 reduction mammaplasties was performed at a single institution over a 10-year period. A literature review of superomedial and inferior pedicle complication rates were performed. Study variables were compared against overall mean complication rates for the two techniques. Logistic regression, paired student T-Tests, and Chi-square analyses were used to calculate adjusted odds ratios and to compare continuous and categorical variables. Results Mean reduction weight was 730 g per breast, ranging from 100 to 4700 g. Overall complication rate was 16%, of which 10% were minor complications related to delayed wound healing. No cases of skin flap necrosis occurred. Increased complications were highly correlated with a BMI > 30, breast reduction weights > 831 g, and sternal notch to nipple distances > 35.5 cm. Conclusions The superomedial pedicle reduction mammaplasty technique is safe and reliable with a complication rate lower than the inferior pedicle technique. Based on our findings we propose that residents should be exposed to this method of reduction mammaplasty as part of a compilation of techniques learned in residency and that practicing surgeons would benefit from becoming familiar with its applications.
Educational Design Research for the Development of a Collectible Card Game for Cybersecurity Learning

The purpose of this paper is to explore the notion of formative design in the context of the design, development, implementation, and evaluation of a collectible card game (CCG) for teaching cybersecurity to middle school students. The approach involved a formative design approach, educational design research (EDR) that evolved from design-based research and design experiments commonly employed in fields such as the learning sciences, educational technology, and instructional design. The authors assert that the EDR process used to design an educational CCG is an effective approach for formative learning game design work.
International spillovers of U.S. financial volatility

Abstract We study the international spillover effects of U.S. bond and stock market volatility using a panel data set of seventeen developed countries. We find significant spillover impacts of U.S. financial market volatility on international output growth. Volatility of U.S bonds with longer maturities is shown to have a more significant impact on international output growth than volatility of U.S. bonds with shorter maturities. Regardless of the maturity of the bonds, U.S. financial market volatility is shown to play a larger role statistically in explaining international output growth than a country’s own financial market volatility.
The Papyrus of the Treasury Scribe Iry-Iry: A New Ramesside Source for a Memphite Hymn to Osiris and the Book of Caves (BD 168):

A publication of the papyrus of Iry-Iry in full with accurate identification of its contents. As a result, a Memphite hymn to Osiris has been identified from several sources gathered together with ...
Clinical outcome of patients managed for late relapse of germ cell tumor

4550 Background: The significance of late relapse (LR) of germ cell tumor (GCT) and its association with poor survival is becoming increasingly recognized. Methods: Between 1990 and 2004, 75 patien...
Supervised Machine Learning with Protein Structural and Network Topological Features Predicts Physical Interactors of the Human Huntingtons Disease Protein.

Huntington's disease is a genetically inherited disorder, causing progressive degeneration of the brain. The mutant protein in Huntington's disease patients exhibits complex biophysical properties, and affects numerous cellular processes. Since numerous proteins interact with either the normal or, the mutant huntingtin protein, or both, to decipher the features that enable this discrimination is a complex problem. We trained a Gradient Boosting Machine (GBM) on several protein-structural features and graph-topological features of the normal and the diseased proteins. The GBM was able to achieve an AUC up to 0.88 in predicting interacting partners of the mutant Huntington's disease protein in 10-fold cross-validation trials.
Ricci v. DeStefano: End of the Line or Just Another Turn on the Disparate Impact Road?

Reports of the death of Title VII's disparate impact theory of discrimination in the wake of Ricci v. DeStefano may be exaggerated. Widely praised and widely criticized in the newspapers and the blogosphere, Ricci is the latest, but perhaps not the last, chapter in a long-running feud between Congress and the Supreme Court regarding disparate impact. While the full implications of the decision remain to be worked out, Ricci certainly made things more complicated for employers. Disparate treatment of minorities remains forbidden. Disparate treatment of white males remains forbidden -- except to avoid disparate impact against minorities. Disparate impact (that is, unjustified disparate impact) against minorities remains forbidden, albeit there is an argument that dicta in Ricci create a "strong basis in evidence" defense even to unjustified disparate impact. The leeway employers had to avoid potential disparate impact suits has been narrowed considerably, but employers still need to assess the impact, the justifications, and the alternatives of various potential courses of action before proceeding. Finally, even where the possibility of disparate impact liability is influencing a course of action, the employer may well remain free to take racial impact into account in choosing among various alternatives (free of disparate impact liability), as long as it does so early enough to avoid disrupting settled expectations.
Coordination of Hybrid Energy Storage for Ship Power Systems With Pulsed Loads

Due to the presence of onboard pulsed loads and other electric loads, medium-voltage direct current system (MVdc), which contains hybrid energy storage, is attracting a lot of interest in ship power system studies. To ensure proper operation of such a system, suitable management is required to maintain the voltage of the MVdc bus and confirm the load-generation balance. Consequently, this article first shows the effect of uncontrolled insertion of pulsed loads on the ship performance. Then, a proposed intelligent coordination algorithm is used to mitigate the effects of pulsed loads and ensure proper power sharing among the storage units, having different available energy. The coordination algorithm differentiates between the transient and steady state needs and takes the proper decision of insertion/removal of the appropriate storage unit and reference values. The algorithm is simulated through MATLAB/Simulink, and then the processor in the loop testing is used to validate the proposed algorithm.
Gene regulatory networks controlling neuronal development: enhancers, epigenetics, and functional RNA

Abstract Gene regulation underlies the diversity in form and function of cell types in the brain. Here, we summarize the basic principles of gene regulatory networks that produce the dynamic expression patterns that distinguish neuronal cell types. We discuss the interplay between regulatory DNA, epigenetics, and relevant proteins and functional RNAs that determine transcriptional output. We present a perspective describing how gene regulatory networks are established that goes from early work defining major transcription factors controlling such networks to recent efforts to understand how such networks function at the molecular and genomic level. Finally, we provide examples of efforts to define the regulatory networks that drive neuronal differentiation and review emerging evidence for a critical role for mutations that perturb such regulatory networks in neurodevelopmental and neuropsychiatric disorders.
Climate change drives increase in modeled HIV prevalence

Long-term changes in temperature can negatively affect human livelihoods with resulting implications for health outcomes. While increasing attention has been paid to the direct health consequences of climate change, there has been less focus on indirect health effects, partly due to the relative complexity of establishing and modeling these outcomes. Here, I leverage a dataset of over 400,000 individuals across 25 countries in Sub-Saharan Africa, coupled with high-resolution climate data for the region, to test the effect of long-run temperature changes on HIV prevalence. I find that warmer periods are linked with an increase in HIV prevalence, particularly for younger generations. Both economic and behavioral changes likely drive this linkage: I find evidence that male migration and sex-market use increase with higher temperatures. I generate projections for future HIV prevalence using two methods. First, I project directly using the empirical estimate, an approach frequently used in econometric studies of climate change impacts. Second, I develop a mechanistic model of HIV spread, incorporating the estimated temperature effect. I find that agreement between the models is strong (77%). Under the RCP8.5 scenario for warming, I find that climate change will lead to between 11.6 and 16.0 million additional cases of HIV by 2050, an increase in prevalence of 1.4–2.1 percentage points.
Application of Fuzzy Unscented Kalman Filter for States and Parameter Estimation of Two-Mass Drive

This paper presents the estimation of mechanical state variables and parameter of the drive system with elastic coupling by using of a Fuzzy Unscented Kalman Filter (FUKF). The adaptive control structure was used with IP controller and two additional feedbacks. The value of mechanical parameter estimated by filter cause retuning of the control structure coefficients. The operation of the proposed structure was checked during simulation and experimental tests.
Electrospinning of Octenylsuccinylated Starch-Pullulan Nanofibers from Aqueous Dispersions

We aimed to develop a greener process for dry-electrospinning food-grade modified starch through the elimination of organic solvents. The rheological properties and electrospinnability of aqueous dispersions of commercial octenylsuccinylated (OS) starches with various molecular weight (Mw) were investigated, yet only nanofibers with beads or defects could be obtained from OS starch with the highest Mw, i.e., Purity Gum@ Ultra (PGU). Further improvement in the fiber morphology was achieved by adding pullulan (PUL) as a minor component in the spinning dope. Smooth, continuous, and bead-free nanofibers (147-250 nm) were obtained from the PGU-PUL dispersions. Shown on an electrospinnability map, the successful electrospinning of 12%, 15%, and 20% (w/v) aqueous PGU dispersions required a minimum addition of 6%, 5%, and 3% (w/v) of PUL, respectively. The addition of PUL contributed to establishing sufficient molecular entanglement for electrospinning. This study provides a promising green process to produce starch-based nanofibers for use in various applications, e.g., drug delivery, wound dressing, and tissue engineering.
Spherical-deformed mixing in Zr 94

I have applied a simple two-state mixing model to $E2$ strengths from a recent $^{94}\mathrm{Zr}(n,{n}^{\ensuremath{'}}\ensuremath{\gamma})$ experiment in order to obtain the mixing amplitudes between spherical and deformed basis states in $^{94}\mathrm{Zr}$. The fits also provide the transition matrix elements connecting the basis states.
Revisiting Primary Otoplasty: Surgical Approach to the Prominent Ear.

SUMMARY Prominent ears and other ear deformities are some of the most common congenital deformities of the head, affecting over 10 percent of the general population. In 2018, more than 10,000 otoplasties were performed in the United States, with over one-third performed on men. The goal of primary otoplasty is creation of a normal-appearing ear without evidence of surgical intervention. This article and video detail the authors' preferred technique for the treatment of prominent ears. This novel method allows for reduction of a hypertrophic concha and obtuse conchoscaphal angle, as well as creation of an adequate antihelical fold.
Cell-level reliability testing procedures for CIGS photovoltaics

The reliability of photovoltaics is commonly studied at the module level. Many reliability problems originate from module attributes, such as metal interconnections to cells, junction boxes. However, significant work in reliability can also be done prior to module design. Testing for reliability earlier in the research cycle increases the probability of avoiding common module reliability problems before cell changes are implemented on a large scale. Cell-level reliability studies can thus lower the rates of module failures in the field and provide confidence to investors that new technologies will perform as advertised. This report summarizes how we investigated three reliability concerns in Cu(In,Ga)Se2 (CIGS) photovoltaics at the cell level: metastability, shading-induced damage, and potential-induced degradation (PID). Examining these concerns required developing robust measurement protocols including the fabrication of novel testing structures. This information will allow readers to incorporate sound metrics for investigating reliability phenomena and aid their studies of cell and module reliability improvements.
The effect of milling additives on powder properties and sintered body microstructure of NiO

The evolution of powder particle size, crystal structure, and surface chemistry was evaluated for micron scale NiO powders subjected to impact milling with commonly employed milling additives: methanol, Vertrel XF, and amorphous carbon. The effect of the different comminution protocols on sintered body microstructure was evaluated for high temperature sintering in inert atmosphere (N2). X-ray photoelectron spectroscopy showed that NiO powder surface chemistry is surprisingly sensitive to milling additive choice. In particular, the proportion of powder surface defect sites varied with additive, and methanol left an alcohol or alkoxy residue even after drying. Upon sintering to intermediate temperatures (1100 ℃), scanning electron microscopy (SEM) showed that slurry milled NiO powders exhibit hindered sintering behaviors. This effect was amplified for NiO milled with methanol, in which sub-500 nm grain sizes dominated even after sintering to 1100 ℃. Upon heating to high temperatures (1500 ℃), simultaneous differential scanning calorimetry/thermogravimetric analysis (DSC/TGA) showed that the powders containing carbon residues undergo carbothermal reduction, resulting in a melting transition between 1425 and 1454 ℃. Taken together, the results demonstrated that when processing metal oxide powders for advanced ceramics, the choice of milling additive is crucial as it exerts significant control over sintered body microstructure.
Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA

The identity of Na+/H+ exchanger (NHE) isoforms in the human small intestine and colon and their role in vectorial Na+ absorption are not known. The present studies were undertaken to examine the regional and vertical axis distribution of NHE-1, NHE-2, and NHE-3 mRNA in the human intestine. Ribonuclease protection assays were used to quantitate the levels of mRNA of these isoforms in various regions of the human intestine. In situ hybridization technique was used to localize NHE-2 and NHE-3 mRNA in the colon. The NHE-1 isoform message was present uniformly throughout the length of the human intestine. In contrast, mRNA levels for human NHE-2 and NHE-3 isoforms demonstrated significant regional differences. The NHE-3 abundance was found in decreasing order: ileum > jejunum > proximal colon = distal colon. The NHE-2 message level in the distal colon was significantly higher than in the proximal colon but was evenly distributed in the small intestine. In addition, NHE-2 mRNA was present in surface epithelial cells as well as in cells of the crypt region, suggesting the presence of NHE-2 message throughout the vertical axis of the colonic crypts. In contrast, NHE-3 mRNA was localized to surface colonocytes in the proximal colon. On the basis of this tissue-specific localization of NHE-2 and NHE-3 mRNA, it can be speculated that the relative contribution of NHE-2 and NHE-3 isoforms in Na+ absorption in the human intestine may be region specific, and these putative apical isoforms may be differentially regulated.
Multi-mission activity planning for Mars lander and rover missions

The Web interface for telescience (WITS) provides downlink data visualization and uplink activity planning for multiple Mars lander and rover missions. WITS also provides a ground data system (GDS) for terrestrial rover operations. The architecture of the WITS system that enables its multi-mission use is described. WITS has been used as the GDS for the Rocky7, FIDO, and Rocky8 rovers at JPL. It was used for command sequence generation for the Mars Polar Lander mission robotic arm and robotic arm camera are to be used for science activity planning in the 2003 Mars Exploration Rover (MER) mission. It is also planned for use in the 2007 Phoenix Mars lander mission and 2009 Mars science laboratory (MSL) rover mission. WITS is currently being integrated with the Mission Data System (MDS) for use in the MSL mission and with the coupled layer architecture for robotic autonomy (CLARAty) system for use as the GDS for terrestrial technology development landers and rovers.
Response-pipelined CAM chips - Building blocks for large associated arrays

The authors introduce the architecture of a new type of fully parallel content addressable memory chips that serve as building blocks for large associated arrays. These new chips can be easily cascaded to increase the logical word size or the number of words and yet allow the search rate to be maintained constant irrespective of the logical word size or word count. Prototype CMOS implementations of the architecture have been tested and evaluated and demonstrated significant speedups compared to other existing associative hardware. >