cssi/SciSciGPT-SciSciNet huggingface dataset:
Subacute Sepsis of the Hip Treated by Antibiotics and Cemented Prosthesis

Nineteen patients suffering from subacute (latent) or recently arrested sepsis of the hip joint were treated by massive doses of antibiotics and total prosthetic reconstruction. A minimum of two years' follow-up is recorded. Recurrence of infection caused failure in two patients, possibly because of inadequate antibiotic treatment. Results were satisfactory in the other seventeen patients, and infection did not recur. The ultimate symptomatic and functional results of reconstruction in the patients with satisfactory results were classified as excellent in nine patients, good in six, and fair in two. One patient with a good result required a revision because of loosening of the prosthesis. All results were considered superior to those from simple resection of the hip (the Girdlestone procedure).
Abstract 4565: Whole exome sequencing links MAPK1 mutation to exquisite sensitivity to brief erlotinib monotherapy in head and neck cancer.

Activating mutations of EGFR, primarily found in a subgroup of lung cancers, serve as predictive biomarkers for EGFR tyrosine kinase inhibitor (TKI) sensitivity. Clinical responses to EGFR TKIs in other cancers are only moderate and predictive biomarkers are lacking. Here, we report a head and neck cancer patient with no EGFR genetic alterations, who experienced a complete histologic clinical response after 14 days of erlotinib monotherapy on a window-of-opportunity presurgical trial. To determine the somatic genetic events underlying the extraordinary and unexpected response to erlotinib alone, whole exome sequencing was performed. A bi-allelic missense mutation of MAPK1(E322K) was detected in the tumor in the absence of other mutations reported to be correlated with EGFR TKI sensitivity in preclinical models or cancer patients. Combined bioinformatics analyses of genomics-drug databases revealed, for the first time, that loss-of-function of MAPK1 or MAPK1 mutation correlates with erlotinib sensitivity. Functional studies confirmed heightened sensitivity to erlotinib by loss-of-function of MAPK1 in HNSCC cells. Our preliminary findings suggest that this MAPK1 mutation, which is also found at low frequencies in HNSCC and cervical cancers, may identify a subgroup of cancer patients who may be cured with EGFR TKI monotherapy. Citation Format: Vivian WY Lui, Eliezer Van Allen, Hua Li, Fan Zhang, Yan Zeng, Jonas T. Johnson, Levi A. Garraway, Gordon B. Mills, Jennifer Rubin Grandis. Whole exome sequencing links MAPK1 mutation to exquisite sensitivity to brief erlotinib monotherapy in head and neck cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4565. doi:10.1158/1538-7445.AM2013-4565
An integrated classifier for computer-aided diagnosis of colorectal polyps based on random forest and location index strategies

Feature classification plays an important role in differentiation or computer-aided diagnosis (CADx) of suspicious lesions. As a widely used ensemble learning algorithm for classification, random forest (RF) has a distinguished performance for CADx. Our recent study has shown that the location index (LI), which is derived from the well-known kNN ( k nearest neighbor) and wkNN (weighted k nearest neighbor) classifier [1], has also a distinguished role in the classification for CADx. Therefore, in this paper, based on the property that the LI will achieve a very high accuracy, we design an algorithm to integrate the LI into RF for improved or higher value of AUC (area under the curve of receiver operating characteristics -- ROC). Experiments were performed by the use of a database of 153 lesions (polyps), including 116 neoplastic lesions and 37 hyperplastic lesions, with comparison to the existing classifiers of RF and wkNN, respectively. A noticeable gain by the proposed integrated classifier was quantified by the AUC measure. Key words : CADx, RF, location index, mixture classifier, AUC, ROC
First principles of hot-tip scanning electrochemical microscopy: Differentiating substrates according to their thermal conductivities

Abstract The use of ac polarized microelectrodes in the arrangement for scanning electrochemical microscopy is described. Application of a high frequency ac waveform to a microelectrode tip results in a resistive heating of the surrounding electrolyte solution and the onset of the electrothermal flow. We report that the presence of a substrate in close proximity to the hot tip leads to a substantial change of the temperature in the hot zone, which in turn results in a measurable effect on the shape of the recorded approach curves. Thus, the observed changes in the faradaic current, measured with the tip, can be used to distinguish substrates according to their thermophysical properties, namely, thermal conductivity. Experimental data are shown to be in good agreement with the results of the theoretical simulations. This work exemplifies initial findings obtained with a novel technique that is termed Hot-Tip Scanning Electrochemical Microscopy (HT-SECM).
171 ORPHANIN FQ/NOCICEPTIN REGULATION OF STERIOD ACTIVATION OF μ-OPIOID RECEPTORS AND SEXUAL BEHAVIOR IN RAT MODELS.

Previous studies have shown that estrogen and progesterone play an important role in facilitating sexual receptivity by regulating the activity of the μ-opioid receptor (MOR) in the medial preoptic nucleus (MPN) and the opioid receptor like receptor (ORL-1) in the ventral medial hypothalamus (VMH). Estrogen rapidly activates MOR in the MPN via the release of β-endorphin originating from neurons in the arcuate, which inhibit lordosis. Subsequent progesterone facilitates lordosis by activating ORL-1 through the release of OFQ/N into the VMH or ARH. Since the ARH projects into the MPN, we hypothesize that infusion of orphanin FQ/nociceptin (OFQ/N) exogenous ligand into the VMH-ARH region will facilitate lordosis by attenuating the activity of MOR inhibitory circuit. Secondly, we will test whether OFQ/N is the endogenous ligand acting in the VMN-ARH region to facilitate lordosis. To test whether OFQ/N activation in the VMH-ARH blocks MOR activity in the MPN and facilitates lordosis, two groups of estrogen primed, nonreceptive ovariectomized rats were either implanted with bilateral cannula aimed at the VMH or a unilateral cannulae aimed at the ARH, using standard stereotaxic procedures. The VMH group was infused with either anti-OFQ (Phoenix 1:10, Neuromics 1:2) to passively immunoneutralize endogenous OFQ/N or normal rabbit serum as control 48 hours post 5 μg estradiol benzoate injection and tested 10 and 90 minutes later to measure sexual receptivity, as measured by lordosis quotient. One week after the behavioral experiment, these animals and the unilateral ARH cannulated animals were treated with 2 μg estrogen and 30 hours later infused with either 25 nmol OFQ/N or artifical cerebrospinal fluid (aCSF). Thirty minutes later, both groups were perfused transcardially with paraformaldehyde and the MPN of each animal was processed for MOR immunohistochemistry. The level of MOR internalization, a marker for receptor activation, was measured by density of immunoreactivity. Immunoneutralization of OFQ/N in the VMH blocked the facilitation of lordosis, indicating that OFQ/N is a relevant ligand in the facilitation of lordosis in the VMH (ANOVA, p
Caffeine effects on velocity selection and physiological responses during RPE production

Caffeine (CAF) blunts estimated ratings of perceived exertion (RPE) but the effects on RPE production are unclear. This study examined effects of acute caffeine ingestion during treadmill exercise where participants exercised at prescribed RPE 4 and 7. Recreational runners (maximal oxygen consumption = 51.4 ± 9.8 mL·kg−1·min−1) (n = 16) completed a maximal treadmill test followed by trials where they selected treadmill velocity (VEL) (1% grade) to produce RPE 4 and RPE 7 (10 min each). RPE production trials followed CAF (6 mg·kg−1) or placebo (PLA) (counterbalanced) ingestion. Participants were blinded to treadmill VEL but the Omni RPE scale was in full view. Repeated-measures ANOVA showed a main effect (trial) for VEL (CAF ∼5 m·min−1 faster) for RPE 4 (p = 0.07) and RPE 7 (p = 0.03). Mean heart rate and oxygen consumption responses were consistently higher for CAF but failed to reach statistical significance. Individual responses to CAF were labeled positive using a criterion of 13.4 m·min−1 faster for C...
Improve or Design Phase

In Chap. 5, methods were described with goals that included clarifying the input-output relationships of systems. The purpose of this chapter is to describe methods for using the information from previous phases to tune the inputs and develop tentative recommendations. The phrase “improvement phase” refers to the situation in which an existing system is being improved. The phrase “design phase” refers to the case in which a new product is being designed.
Revised Classification of Epilepsies

The proposals for a revised classification of epilepsy and epileptic syndromes (1981-1985) have again been revised by the Commission on Classification and Terminology of the International League Against Epilepsy.
Interfacial Phenomena During Chemical Vapor Deposition

Chemical vapor deposition (CVD) is a material synthesis method whereby the constituents of the vapor phase react to form a single or multicomponent, vitreous or crystalline solid film, coating or bulk shape on a substrate surface. Typical reactions include pyrolysis, reduction, oxidation, hydrolysis, nitride and carbide formation and synthesis. The desired deposition reaction is almost always heterogeneous i. e., it occurs at the substrate surface rather than in the gas phase (homogeneous reaction), as the latter type of reaction normally causes deposits composed of powder or flakes. Epitaxy is the regular oriented growth of a monocrystalline substance on another one. When an epitaxial film is grown on a substrate of the same type of material, one has homoepitaxy; if growth occurs on a different substance, it is considered heteroepitaxy. Kern and Ban1 have recently reviewed the CVD process as well as provided an extensive bibliography concerned with fundamental aspects, reactor systems and process control techniques, applications for preparing important and representative materials and previous reviews and conference proceedings.
CT Imaging for Parathyroid Disease

The use of CT for parathyroid imaging is an emerging technique offering precise localization of parathyroid lesions with high sensitivity and accuracy relative to other commonly employed preoperative imaging modalities. This chapter covers the basis of the utility of CT for parathyroid imaging, patient selection, technical factors, and test characteristics of the multi-phase parathyroid CT.
ArtThrust Teen Empowerment Program: Teaching Youth to Fly Against Resistance

ABSTRACTMany communities across the United States are striving to foster positive social change, despite limited financial and human resources. Although there is no formula for change that will work in every community, transformation is happening through the efforts of artists and social workers using group methods. This article illustrates one model that connects contemporary art making, social practice art, and group art methods with art therapy activities. It will provide the foundational principles used in the ArtThrust Teen Empowerment Program to create positive change for lesbian, gay, bisexual, transgender, queer or questioning youth within a one-week intensive art-based program.
Impact of Provider Recommendation on Tdap Vaccination of Adolescents Aged 13-17 Years.

Introduction Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination has been recommended for adolescents in the U.S. since 2006. Information on Tdap vaccination by provider recommendation is limited. The purpose of this study is to assess recent Tdap vaccination by provider recommendation status among adolescents aged 13–17 years. Methods The 2013 National Immunization Survey-Teen data (N=18,948) were analyzed in 2016 to assess national and state-specific Tdap vaccination coverage disparities among adolescents by provider recommendation status, and other demographic and access to care variables. Multivariable logistic regression analysis and predictive marginal modeling evaluated associations between Tdap vaccination and provider recommendation status and other factors among adolescents aged 13–17 years. Results Overall, only 56.9% of adolescents aged 13–17 years received a provider recommendation for Tdap. Coverage was significantly higher among adolescents with a provider recommendation (88.6%) compared with those without a provider recommendation (80.5%) ( p p Conclusions Provider recommendations were significantly associated with Tdap vaccination among adolescents aged 13–17 years. However, 43% of parents of adolescents did not receive a provider recommendation. Evidence-based strategies such as standing orders and provider reminders alone or health systems interventions in combination should be taken to improve provider recommendation and Tdap vaccination coverage.
The Emergent Nematic Phase in Ionic Chromonic Liquid Crystals.

Chromonic liquid crystals exhibit a unique self-assembly process which is of both theoretical and practical interest. A characteristic feature of chromonics is the occurrence of molecular association through stacking at extremely low concentrations. Experimental evidence has suggested that this process is approximately isodesmic across a broad concentration range. Another important aspect of these phases is a separation of energy scales for elastic deformation that leads to novel bulk morphologies and defect arrangements. To date, only a handful of computational studies have managed to reproduce crucial aspects of chromonic phases, with ionic chromonics treated only by expensive fully atomistic simulations. Here, we present a simple model based on the competition between long-range repulsions and short-range anisotropic attractions capable of capturing all features of the chromonic phase. Molecular simulations of coarse-grained mesogens are used to map out the phase behavior and explore how structural and...
A Progressive Running Program for an Adolescent With Cerebral Palsy.

PURPOSE To describe the physical therapy intervention and outcomes for a 20-week progressive running program. SUMMARY OF KEY POINTS A 12-year-old boy with spastic diplegic cerebral palsy, Gross Motor Function Classification System level II, participated in a 20-week running program. The 6-minute walk test and the 88-item and 66-item versions of the Gross Motor Function Measure (GMFM) were administered at baseline and program completion. After completion of the program, the participant exceeded thresholds for minimally clinically important differences on the GMFM-66 total score and GMFM-88 Dimension D and E scores. He improved gait speed and distance walked during the 6-minute walk test. CONCLUSIONS AND RECOMMENDATIONS FOR CLINICAL PRACTICE Participation in a progressive running program is a feasible intervention to promote improvements in walking speed and gross motor function in some adolescents with spastic diplegic cerebral palsy in Gross Motor Function Classification System level II.
Effect of positive perioperative donor and recipient respiratory bacterial cultures on early post-transplant outcomes in lung transplant recipients

Background It is standard practice to administer prophylactic antibiotics post lung transplantation. However, no studies have evaluated the impact of culture positivity. The purpose of this study was to evaluate early post-transplant outcomes of culture-positive and culture-negative lung transplant (LT) recipients and the appropriateness of the empiric regimens used. Methods Adult patients who received an LT at Emory University Hospital between January 1, 2010 and August 31, 2015 were reviewed and stratified into three groups: (i) culture-positive appropriate empiric treatment, (ii) culture-positive inappropriate empiric treatment, and (iii) culture-negative. Antibiotics were defined as appropriate if bacteria were sensitive to the empiric regimen. The primary endpoint was 30-day mortality. Secondary endpoints included hospital length of stay (LOS), intensive care unit (ICU) LOS, percent neutrophil count in a bronchoalveolar lavage (BAL), presence of airway ischemia, and appropriateness of the empiric antibiotic regimen. Results Respectively nine, zero, and four patients died within 30 days in the culture-positive appropriate (n=113), culture-positive inappropriate (n=5), and culture-negative groups (n=29) (P=.564). The median hospital LOS was 19, 16, and 15 days respectively. Median ICU LOS was 6, 5, and 7 respectively. The respective percent neutrophil counts in the BAL fluid were 79, 83, and 65. The presence of airway ischemia was only documented in eight patients, all in the culture-positive appropriate group. Conclusion We did not identify an association between antibiotic appropriateness and 30-day mortality, hospital LOS or ICU LOS in post-LT recipients. This article is protected by copyright. All rights reserved.
Spirituality and Religion: The Ninth CACREP Core Curriculum Area

On the basis of the ACA Code of Ethics (American Counseling Association [ACA], 2014) and ACA-endorsed competencies, the ability to address spirituality and religion is a recommended skill set of counselors. The Council for Accreditation of Counseling and Related Educational Programs (CACREP) addresses the “spirit” in the standards; however, in the training of students, additional focus could be placed on this competency. The authors introduce expert-reviewed standards to be considered as a 9th core curriculum area of the CACREP Standards (CACREP, 2015) titled Spirituality and Religion.
Increasing the Practice of Preventive Medicine in a Clinical Setting

In the practice of preventive medicine there often is a discrepancy between physicians’ attitudes and behavior. Surveys of physicians (Daly 1980; Hill 1976; Wechsler 1983; Berg 1978) in primary care consistently report a strong interest in health promotion and a willingness to help patients develop a healthier life style. Studies (Cohen 1982; Romm 1981; Mandel 1982; Bates 1970) of the behavior of these physicians, however, report inconsistent utilization of screening tests as well as a lack of confidence in using skills, such as counseling, that promote health. For example, the few studies (Cohen 1982; Bates 1970; Carter 1981) that exist on the rate of referral for mammography report a referral rate ranging from only 1–5%.
Culture, Change, and their Effects on Children:

Three culturally related changes in adult attitudes toward children and youth, while not entirely negative in implication, are potential sources of conflict
THE HOME TREATMENT

It is now recognized that alcohol addiction generates problems that extend beyond the heavy drinker to the family and particularly the spouse. Yet for several decades, when the spouse (and especially the wife) was the focus of research, primary emphasis was on her as an unwitting causal agent in her husband’s problem drinking, due to the presumed presence of “pathological” personality traits such as dominance, dependency, or sadomasochism. More recently, Steinglass and others11,16–18 have taken a functionalist, systems approach and attempted to show that the wife is a part of a family ”system“ that may help maintain the husband’s problem drinking. Where the focus has been on the coping behavior of wives of alcoholics, investigators have been concerned with their management of the problem over a considerable time span of their husband’s drinking career and do not detail early attempts to get their husbands to stop or cut down.4–8,10 This effort to fit the wife into the etiology of alcoholism, or condense her attempts to cope with a husband’s long drinking career into major stages, has resulted in ignoring what might be the first line of defense in the battle with a man’s compulsive drinking behavior—the wife’s early intervention efforts.
Distributed Safety-Critical Systems

The use of computers in systems which have a direct or indirect effect on human, environmental, and equipment safety is prevalent. This paper presents an overview of the problems encountered by those designing safety-critical systems along with the fundamental definitions and concepts employed by their design. A survey of such designs is also presented along with a generic safety-critical system design model. Finally, a taxonomy of safety-critical system designs is presented which classifies the known design solutions. It is the authors’ hope that this information will aid current and future designers of safety-critical systems to understand their design-space and to quickly assemble candidate solutions for their particular problem.
Comparison of Static Neural Network with External Memory and RNNs for Deterministic Context Free Language Learning

In this paper, a learning model for prediction is introduced by coupling a static neural network with an external stack memory, creating a new type of recurrent system. We analyze the differences between this external memory recurrent network and recurrent neural network, which possesses internal memory. Internal memory remembers the last state while external memory remembers past useful contents. For a specific automaton, the internal memory is needed if the last state is a variable of the state transition function and the external memory is needed if the past content is a variable of state transition function. Our arguments are verified by comparing the prediction accuracy of different models with internal memory, external memory and the combination of them on counting and reversing tasks. The results shows that: network with an external stack works best for counting tasks since the variables of state transition function is composed of the current input and one past input, while network with the combination of internal and external memory works best for the reversing task since the variables of state transition function is composed of the current input, current state and the past inputs.
Cutaneous Adverse Effects of Diabetes Mellitus Medications and Medical Devices: A Review.

Diabetes mellitus is one of the most prevalent chronic diseases in the USA. If uncontrolled, diabetes can lead to devastating complications. Diabetes medications and medical devices largely contribute to the significant financial expense that the disease inflicts on affected individuals and society. Alongside significant economic burden, there are numerous cutaneous adverse effects associated with diabetes medications and medical devices. Despite the large and increasing number of individuals living with diabetes and the wide use of the related medications and medical devices, there is limited literature that comprehensively documents their cutaneous adverse effects. These cutaneous adverse effects are significant as they can worsen glycemic control, increase disease distress, and may increase risk of associated complications. Thus, it is important that providers can recognize these cutaneous adverse effects, identify the culprit agents, and can properly manage them. In this article, we provide a critical review of the cutaneous adverse effects of medications and devices used in the management of diabetes and provide insight into risk factors and prevention and an overview of therapeutic management. An emphasis is placed on clinical recognition and treatment for use of the medical providers who, regardless of practice setting, will treat patients with diabetes.
Automatic Registration of Serial Cerebral Angiography: A Comparative Review

Image registration can play a major role in medical imaging as it can be used to identify changes that have occurred over a period of time, thus mirroring treatment effectiveness, recovery, and detection of diseases onset. While medical image registration algorithms have been largely evaluated on MRI and CT, less attention has been given to Digital Subtraction Angiography (DSA). DSA of the brain is the method of choice for the diagnosis of numerous neurovascular conditions and is used during neurovascular surgeries. Numerous studies have relied on semi-automated registration that involve manual selection of matching features to compute the mapping between images. Nevertheless, there are currently a variety of automatic registration methods which have been developed, although the performance of these methods on DSA have not been fully explored. In this paper, we identify and review a variety of automatic registration methods, and evaluate algorithm performance in the context of serial image registration. We find that intensity-based methods are consistent in performance, while feature-based methods can perform better, but are also more variable in success. Ultimately a combined algorithm may be optimal for automatic registration, which can be applied to analyze vasculature information and improve unbiased treatment evaluation in clinical trials.
Living Apart Together as a “Family Form” Among Persons of Retirement Age: The Appropriate Family Law Response

This article discusses the phenomenon of “living apart together,” or LAT, among persons of retirement age. LATs are committed couples who maintain separate residences. The article first explores the literature on sexuality and dating among older persons and then discusses social science research done, primarily outside of the U.S., about LAT among persons in older age groups. It then describes what was learned from the author’s own interviews of LATs over the age of 65 about their reasons for living apart, their manner of life, economic arrangements, and mutual caregiving. Based on this research, it reaches a number of conclusions about what the appropriate legal treatment of these couples should be.
Resistance of House Fly, Musca domestica L. (Diptera: Muscidae), to Five Insecticides in Zhejiang Province, China: The Situation in 2017.

Objectives. High dependency on pesticides could cause selection pressure leading to the development of resistance. This study was conducted to assess the resistance of the house fly, Musca domestica, to five insecticides, namely, permethrin, deltamethrin, beta-cypermethrin, propoxur, and dichlorvos, in Zhejiang Province. Methods. Field strains of house flies were collected from the 12 administrative districts in Zhejiang Province in 2011, 2014, and 2017, respectively. Topical application method was adopted for the bioassays. The probit analysis was used to determine the median lethal doses with the 95% confidence interval, and then the resistance ratio (RR) was calculated. The insecticides resistance in different years and the correlations of the resistance between different insecticides were also analyzed. Results. The resistance of field strains house flies to insecticides in Zhejiang Province was relatively common, especially for permethrin, deltamethrin, and beta-cypermethrin. The reversion of the resistance to dichlorvos was found, and most of the field strains in Zhejiang Province became sensitive to dichlorvos in 2017. Propoxur was much easier to cause very high level of resistance; the Hangzhou strain had the highest RR value more than 1000 in 2014, and five field strains had the RR value more than 100 in 2017. Compared to 2011 and 2014, the resistance of the house flies to propoxur and deltamethrin increased significantly in 2017. The resistance of permethrin, deltamethrin, beta-cypermethrin, and propoxur was significantly correlated with each other, and the resistance of dichlorvos was significantly correlated with beta-cypermethrin. Conclusions. Our results suggested that resistance was existed in permethrin, deltamethrin, beta-cypermethrin, and propoxur in the house flies of Zhejiang Province, while the resistance reversion to dichlorvos was found.
Filter-free optofluidic micropipette devices for fluorescence sensing

We demonstrate a novel optofluidic micropipette device for filter-free fluorescence-based biosensing. The optofluidic micropipette tube composed of a glass capillary microtube and a polymer-based structure designed to load analyte solution using a regular micropipette and serves as an optical waveguide. Ray-tracing simulations suggest that the excitation light can be effectively guided along the glass capillary with a small amount of leakage through the scattering at the solutionair interface. Fluorescence emission of the analyte propagates in the radial direction of the glass capillary which can be efficiently captured by a smartphone camera through a miniaturized objective lens. Fluorescence intensity and spectra were characterized using Rhodamine 6G (R6G) with various concentrations. The emission was collected via a microscope with 5X magnification and a smartphone camera. Both experimental and simulation results suggest that the excitation rays are efficiently coupled into the glass micropipette tube for fluorescence excitation. The fluorescence emissions from the analyte will either pass along the glass tube or propagate in the radial direction collected by the detector. A limited amount of excitation leakage scattered from the liquid-air interface showed a minimal effect on fluorescence detection. We demonstrated the platform that combines the optofluidic micropipette and smartphone camera to detect steroid hormone.
Short-term Calorie Restriction and 17α-Estradiol Administration Elicit Divergent Effects on Proteostatic Processes and Protein Content in Metabolically Active Tissues

17α-Estradiol (17α-E2) is a "non-feminizing" estrogen that extends life span in male, but not female, mice. We recently reported that 17α-E2 had robust beneficial effects on metabolic and inflammatory parameters in aged male mice. However, it remains unclear if 17α-E2 also delays other "hallmarks" of aging, particularly maintaining proteostasis. Here, we used isotope labeling methods in older mice to examine proteostatic mechanisms. We compared weight-matched mild calorie restricted (CR) and 17α-E2 treated male mice with the hypothesis that 17α-E2 would increase protein synthesis for somatic maintenance. 17α-E2 had no effect on protein synthesis or DNA synthesis in multiple tissues, including white adipose tissue. Conversely, mild short-term CR decreased DNA synthesis and increased the protein to DNA synthesis ratio in multiple tissues. Examination of individual protein synthesis and content did not differentiate treatments, although it provided insight into the regulation of protein content between tissues. Contrary to our hypothesis, we did not see the predicted differences in protein to DNA synthesis following 17α-E2 treatment. However, mild short-term CR elicited differences consistent with both lifelong CR and other treatments that curtail aging processes. These data indicated that despite similar maintenance of body mass, 17α-E2 and CR treatments elicit distinctly different proteostatic outcomes.
PCR monitoring of response in patients treated with high-dose chemotherapy for low-grade lymphoma

The ability to detect lymphomatous infiltration is important not only for the accurate staging of disease at diagnosis but also to monitor the response to therapy. Although patients with advanced-stage low-grade lymphoma often achieve clinical complete remission, the majority of these patients ultimately relapse. The source of such relapse is most likely residual lymphoma cells that are below the limit of detection using standard diagnostic techniques. Therefore, considerable effort has been made over the past decade to develop new techniques that have greatly increased the sensitivity of detection of minimal residual disease. In particular, the identification of specific gene rearrangements and chromosomal translocations of neoplastic cells has permitted the development of sensitive molecular techniques that are capable of detecting minimal residual malignant cells. Because of the specific nature of the gene rearrangements of their antigen receptor genes, the lymphoid malignancies have been studied most extensively. Tumor-specific DNA sequences occur also at the sites of nonrandom chromosomal translocations and are candidates for detection by molecular biologic techniques. With the development of these more sensitive techniques for the detection of lymphoma, the presence of residual lymphoma cells in patients in complete clinical remission, commonly called minimal residual disease, has been demonstrated clearly. It would seem obvious that if such residual lymphoma cells can be detected in a patient, then additional therapy would be necessary for cure. However, this has never been conclusively established for the minimal residual numbers of lymphoma cells that can now be detected izn patients following achievement of a clinical complete remission. Therefore, the critical issue is to determine whether such sensitive detection of residual lymphoma cells by PCR will identify which patients will relapse. If this proves to be the case, then molecular biologic techniques will become a routine part of staging and follow-up of patients with lymphoma and will redefine our concept of complete remission.
Editorial Commentary: So Your Knee Has a Big Pivot Shift Before Anterior Cruciate Ligament Surgery-Why Does that Matter???

Abstract Control of anterolateral knee laxity has always been a major goal of anterior cruciate ligament (ACL) reconstruction. The recent focus on the anatomy of the anterolateral knee and new studies demonstrating decreased graft failure risk with the additional of lateral procedures to intra-articular ACL reconstruction have given these procedures new relevance. A key question that drives indications is which patients benefit the most from these procedures. Those patients with increased rotational knee laxity, particularly in the absence of a repairable meniscus injury, may be good candidates. ACL injury chronicity, bony anatomy, concomitant anterolateral injury, and other factors all contribute to increased anterolateral knee laxity. This high laxity population is ideal for evaluation of the effectiveness of new methods to control knee laxity and improve outcomes of isolated intra-articular ACL reconstruction.
Identifying Project Opportunity Gaps Using a Descriptive Literature Review: 2010-2019

The purpose of this paper is to identify gaps in the opportunity management literature (as a subset of overall risk management) and to identify future research in opportunity management. The methodology is non-experimental using a descriptive literature review content analysis of opportunity management articles published between 2010 and 2019. The identified strengths and weaknesses establish a future research agenda including process steps and tailoring, risk exposure, and balanced risk. The research resulted in a repeatable methodology that can be applied to other research domains in addition to the opportunity management research agenda.
Variability in commercially available deformable image registration: A multi-institution analysis using virtual head and neck phantoms

PURPOSE The purpose of this study was to evaluate the performance of three common deformable image registration (DIR) packages across algorithms and institutions. METHODS AND MATERIALS The Deformable Image Registration Evaluation Project (DIREP) provides ten virtual phantoms derived from computed tomography (CT) datasets of head-and-neck cancer patients over a single treatment course. Using the DIREP phantoms, DIR results from 35 institutions were submitted using either Velocity, MIM, or Eclipse. Submitted deformation vector fields (DVFs) were compared to ground-truth DVFs to calculate target registration error (TRE) for six regions of interest (ROIs). Statistical analysis was performed to determine the variability between each DIR software package and the variability of users within each algorithm. RESULTS Overall mean TRE was 2.04 ± 0.35 mm for Velocity, 1.10 ± 0.29 mm for MIM, and 2.35 ± 0.15 mm for Eclipse. The MIM mean TRE was significantly different than both Velocity and Eclipse for all ROIs. Velocity and Eclipse mean TREs were not significantly different except for when evaluating the registration of the cord or mandible. Significant differences between institutions were found for the MIM and Velocity platforms. However, these differences could be explained by variations in Velocity DIR parameters and MIM software versions. CONCLUSIONS Average TRE was shown to be <3 mm for all three software platforms. However, maximum errors could be larger than 2 cm indicating that care should be exercised when using DIR. While MIM performed statistically better than the other packages, all evaluated algorithms had an average TRE better than the largest voxel dimension. For the phantoms studied here, significant differences between algorithm users were minimal suggesting that the algorithm used may have more impact on DIR accuracy than the particular registration technique employed. A significant difference in TRE was discovered between MIM versions showing that DIR QA should be performed after software upgrades as recommended by TG-132.
Semisubmersible Offshore Structure in an Extreme Wave Domain with Itinerant Ice Pieces

Presence of nomadic ice pieces of various sizes in the North Seas such as, in the Grand Bank area of Newfoundland and Labrador largely inflicts extra threats to the operations and stability of semisubmersible offshore structures (SOS). During stormy weather or in a situation of very large waves, the operation and safety of such SOS are extremely risked when ices pieces propagating alongside with the heavy waves. This paper reports initial findings for the effects of various large waves on the risk of occurrence and severity of ice pieces and topside collisions. OrcaFlex™ is a commercial code utilized in this project as the numerical simulator. This is a 3D non-linear time-domain finite element implicit and explicit code that utilizes lumped mass elements to simplify equations and to enhance computational efficiency. The results obtained from the OrcaFlex code are compared with the results predicted by StarCCM+ full scale dispersive commercial code for an alike case. The comparisons of the data show a valuable data match.
New taxonomic and nomenclatural acts in Cephenniini (Coleoptera: Staphylinidae: Scydmaeninae).

Status of some species and names in Cephenniini is clarified. Cephennium ovatum Nietner is transferred to Cephennodes resulting in Cephennodes (incertae sedis) ovatus comb. n.; Cephennodes zwaluwenburgi Zimmerman is placed in the nominotypical subgenus; Cephennium felicitas Scott is transferred to Pomphopsilla Jaloszynski, resulting in Pomphopsilla felicitas comb. n.; Pseudocephennium maximum Jaloszynski is placed as a junior synonym of Pseudocephennium integricolle Reitter; and Cephennomicrus ignarus nom. n. is proposed as a replacement name for the preoccupied Cephennomicrus impressus Jaloszynski.
Medical Data and Mathematically Modeled Implicit Surface Real-Rime Visualization in Web Browsers

Raycasting can display volumetric medical data in fine details and reveal crucial inner imaging information, while implicit surface is able to effectively model complex objects with high flexibilit...
Outcomes of gynecologic oncology patients at an epicenter of the COVID-19 pandemic

Objectives: To describe the clinical course and associated mortality and morbidity of gynecologic cancer patients with COVID-19 infection with respect to cancer status, demographics, and comorbidities. Methods: An IRB approved prospective registry was initiated of all gynecologic oncology patients with COVID-19 infections at a health care system in New York City from March 1 to June 1 2020. Clinical and demographic data was abstracted from the electronic medical record. Univariate and multivariate regression analyses were performed to identify factors associated with development of an adverse event defined as the composite of death, intubation, or ICU admission. Results: In total, 57 gynecologic cancer patients with documented COVID-19 positivity were identified. The median age of identified patients was 68 years (range 32 - 91years). 29 patients (50.9%) required hospital admission and 28 (49.1%) patients required supplemental oxygen. 17 patients (30%) experienced an adverse event, defined as the composite of death, intubation, or ICU admission. Specifically 7 (12%) were intubated, 13 (23%) were admitted to the ICU, and 16 (27%) patients died from acute complications of COVID-19. All patients who were intubated and/or admitted to the ICU died from COVID-19 complications. Patients with elevated white blood cell count (WBC), absolute neutrophil count (ANC) and/or elevated prothrombin time (PT) were significantly more likely to experience an adverse event (WBC: 47 vs 12%, p=0.01; ANC: 37 vs 8%, p=0.04; PT: 61 vs 17%, p=0.04). On multivariable analysis, ECOG status of 1 or greater was associated with a 26-fold increase in the odds of an adverse event (OR=26, 95% CI: 2 - 415, p=0.02), and seven or more abnormal lab values was associated with a 305-fold increase in the odds of an adverse event (p=0.007). The presence of active cancer (n=33. 57.9%) or receipt of systemic therapy (n=18, 31.6%) was not associated with the development of an adverse event (p=0.205, p=0.81 respectively). Type of systemic therapy (chemotherapy, immunotherapy, radiation) was not associated with adverse event development. Download : Download high-res image (83KB) Download : Download full-size image Conclusions: In this study, we analyzed the outcomes of gynceocologic oncology patients with COVID-19 infections at an urban New York City hospital. Over 50% of patients required hospital admission for COVID-19 related symptoms, with a case fatality rate of 27%. Age, active cancer status, or recent systemic therapy was not associated with subsequent intubation, ICU admission, or mortality, while performance status and multiple abnormal lab values were significant risk factors. Further characterization of associated poor prognostic factors is needed in order to formulate best oncologic practices during the COVID-19 pandemic.
Assessing the Knowledge State of Online Students - New Data, New Approaches, Improved Accuracy.

We consider the problem of assessing the changing knowledge state of individual students as they go through online courses. This student performance (SP) modeling problem, also known as knowledge tracing, is a critical step for building adaptive online teaching systems. Specifically, we conduct a study of how to utilize various types and large amounts of students log data to train accurate machine learning models that predict the knowledge state of future students. This study is the first to use four very large datasets made available recently from four distinct intelligent tutoring systems. Our results include a new machine learning approach that defines a new state of the art for SP modeling, improving over earlier methods in several ways: First, we achieve improved accuracy by introducing new features that can be easily computed from conventional question-response logs (e.g., the pattern in the student's most recent answers). Second, we take advantage of features of the student history that go beyond question-response pairs (e.g., which video segments the student watched, or skipped) as well as information about prerequisite structure in the curriculum. Third, we train multiple specialized modeling models for different aspects of the curriculum (e.g., specializing in early versus later segments of the student history), then combine these specialized models to create a group prediction of student knowledge. Taken together, these innovations yield an average AUC score across these four datasets of 0.807 compared to the previous best logistic regression approach score of 0.766, and also outperforming state-of-the-art deep neural net approaches. Importantly, we observe consistent improvements from each of our three methodological innovations, in each dataset, suggesting that our methods are of general utility and likely to produce improvements for other online tutoring systems as well.
Anticoagulation Monitoring for Perioperative Physicians.

From preoperative medications to intraoperative needs to postoperative thromboprophylaxis, anticoagulants are encountered throughout the perioperative period. This review will focus on coagulation testing clinicians utilize to monitor the effects of these medications.
The Changing Role of Surgery in the Treatment of Cancer

When consideration is given to recent advances and progress made in the treatment of cancer, little attention is directed toward those changes taking place that are probably as profound and as far reaching in consequence as are any in our time. To many—particularly those in other disciplines—the surgical approach to cancer is deemed anachronistic in concept. While categorically such may be true, the leading edge of that specialty is attempting to redefine the basis for cancer surgery so that it is in keeping with present understanding of tumor biology.
Contagion of Liquidity Crisis between Firms

In this paper, I present a model in which contagion of the liquidity crisis between non- nancial institutions occurs due to the co-creditors learning behavior. The fact that di¤erent rms share the same group of creditors leads to the transmission of information on the type of other creditors from one rm to the other. That is, after observing what happens in one rm, creditors get to conjecture the type of other creditors. And when they decide their actions in another rm, creditors reect this information. Without common knowledge of each rms fundamentals, each rms switching equilibrium the threshold for the liquidity crisis there is uniquely determined and particularly the latter rms equilibrium is a¤ected by creditors updated beliefs on the other creditors type. Analysis of these switching equilibria shows that the contagion of the liquidity crisis from the rm having a small possibility to fail is more propagable than otherwise. Comparative statics analysis provides policy proposals to mitigate the severity of contagion on the liquidity crisis in the latter rm. (JEL G33, G38, D82, D83)
Perceptions and Preferences of Study Abroad: Do Business Students Have Different Needs?.

Abstract This research compares the study-abroad perceptions and preferences of business and non-business majors. The results suggest that the two groups have somewhat different motivations for studying abroad. On balance, business students appear more pragmatic than their non-business counterparts, expressing greater concern for financial issues, and the effects of study abroad on both graduation dates and future job prospects. However, the two groups expressed virtually unanimous agreement when asked to describe their specific preferences regarding a study-abroad program. The results suggest that although the two groups seem driven by different motivations, their study-abroad needs may be satisfied by a single, carefully designed program.
Municipal Bonds and Monetary Policy: Evidence from the Fed Funds Futures Market

This paper examines the impact of conventional and unconventional monetary policy on municipal bonds using a novel high-frequency dataset. I use three proxies for monetary policy surprises: the surprise change to the current federal funds target rate, the surprise component in the Federal Open Market Committee (FOMC) balance-of-risk statement, and the unanticipated announcements of future large-scale asset purchases. Estimation results show that monetary policy news have economically important and highly significant effects on municipal bond prices. Their daily responses are, however, substantially lower than the reaction of comparable Treasury notes. This work documents that market (in)efficiency, and the slow adjustment of municipal bond prices, can partially rationalize this discrepancy. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark 34:434–450, 2014
Settlement Ecology: The Social and Spatial Organization of Kofyar Agriculture

Settlement Ecology: The Social and Spatial Organization of Kofyar Agriculture. Glenn Davis Stone. Tucson: University of Arizona Press, 1996. 256 pp.