cssi/SciSciGPT-SciSciNet huggingface dataset:
Scaffold Functions of 14-3-3 Adaptors in B Cell Immunoglobulin Class Switch DNA Recombination

Class switch DNA recombination (CSR) of the immunoglobulin heavy chain (IgH) locus crucially diversifies antibody biological effector functions. CSR involves the induction of activation-induced cytidine deaminase (AID) expression and AID targeting to switch (S) regions by 14-3-3 adaptors. 14-3-3 adaptors specifically bind to 5′-AGCT-3′ repeats, which make up for the core of all IgH locus S regions. They selectively target the upstream and downstream S regions that are set to undergo S–S DNA recombination. We hypothesized that 14-3-3 adaptors function as scaffolds to stabilize CSR enzymatic elements on S regions. Here we demonstrate that all seven 14-3-3β, 14-3-3e, 14-3-3γ, 14-3-3η, 14-3-3σ, 14-3-3τ and 14-3-3ζ adaptors directly interacted with AID, PKA-Cα (catalytic subunit) and PKA-RIα (regulatory inhibitory subunit) and uracil DNA glycosylase (Ung). 14-3-3 adaptors, however, did not interact with AID C-terminal truncation mutant AIDΔ(180–198) or AIDF193A and AIDL196A point-mutants (which have been shown not to bind to S region DNA and fail to mediate CSR). 14-3-3 adaptors colocalized with AID and replication protein A (RPA) in B cells undergoing CSR. 14-3-3 and AID binding to S region DNA was disrupted by viral protein R (Vpr), an accessory protein of human immunodeficiency virus type-1 (HIV-1), which inhibited CSR without altering AID expression or germline IH-CH transcription. Accordingly, we demonstrated that 14-3-3 directly interact with Vpr, which in turn, also interact with AID, PKA-Cα and Ung. Altogether, our findings suggest that 14-3-3 adaptors play important scaffold functions and nucleate the assembly of multiple CSR factors on S regions. They also show that such assembly can be disrupted by a viral protein, thereby allowing us to hypothesize that small molecule compounds that specifically block 14-3-3 interactions with AID, PKA and/or Ung can be used to inhibit unwanted CSR.
Utilization by fishes of shallow, seagrass-covered banks in Florida Bay: 1. Species composition and spatial heterogeneity

Species composition and relative capture rates of water column fishes occurring on the shallow (<1 m), seagrass-covered mudbanks of Florida Bay were assessed using small-mesh gillnets. The fauna was largely temperate, with few tropical representatives, and was similar to the fish community in adjacent basins. There was a high variability in the catch across the Bay, reflecting heterogeneity in both the physical environment and various aspects of the seagrass canopy. The Gulf site, in the northwestern section of the Bay, had the highest species richness and highest capture rates of individual species, relative to other sites. Higher densities of potential prey, greater available foraging area, and organically rich, fine sediments are probably influential in the greater fish utilization of this bank. The greater exchange of western Florida Bay with open Atlantic or Gulf waters is proposed as a secondary factor influencing species richness; the probability of non-resident species occasionally appearing on western banks is greater than in isolated interior sections of the Bay.
Risk of death in cystic fibrosis patients with severely compromised lung function.

Background Lung disease accounts for most of the mortality in patients with cystic fibrosis (CF). Lung transplantation is an option for patients severely impaired, being recommended when life expectancy is estimated to be Methods Data were retrieved from CF patients followed up at our center who reached and kept an FEV1 Results The median survival was 3.9 years (95% confidence interval, 2.88 to 4.12 years), with no significant differences according to gender, nutritional status, presence of diabetes, or decade in which the patient was cared for. Only by age was there a significant difference in the median survival (p Conclusion In our patient population, a cutoff value of FEV1 of
Individual differences in information processing: An investigation of intellectual abilities and task performance during practice ☆

Abstract A conceptual theory for predicting the relations between intellectual abilities and performance during task practice is proposed and evaluated. This macro-theory integrates modern hierarchical theories of intellectual abilities with information-processing theories of automatic and controlled processing (Schneider & Shiffrin, 1977) and performance-resource functions (Norman & Bobrow, 1975). An empirical evaluation of the theory is provided from an experiment with high school and college students. Subjects practiced for several hours on verbal and spatial memory tasks with consistent and varied information-processing manipulations. Derived correlations between ability factors and task performance measures indicate support for the theory and support for linkage of the concepts of intellectual abilities and attentional resources.
Radiologic evaluation of soft tissue tumors. A retrospective study.

The radiologist's ability to evaluate soft tissue tumors is clearly limited. Features which have diagnostic significance include radiographic density, homogeneity, and alterations in the adjacent bone or adipose tissue. Relevant information is potentially available by plain film examination but requires technical excellence with special attention to soft tissue detail and choice of projections. The role of special techniques, including angiography, is discussed, and the results of a “blind” retrospective evaluation of the roentgenograms in 60 histologically verified neoplasms are presented.
Directed Oxidative Cyclizations to C2- or C4-Positions of Indole: Efficient Construction of the Bicyclo[4.3.1]Decane Core of Welwitindolinones

Regiocontrolled oxidative cyclizations of 3-substituted indoles are described herein. Specifically, it is shown that the installation of a chloride at C2 alters the inherent propensity for cyclization at the 2-position of indole so as to favor the 4-position, enabling the construction of the unique framework found in most welwitindolinone alkaloids. The chloride functions here as more than a blocking group, as it also provides ready access to the corresponding oxindole.
Patterns of prescription drug expenditures and medication adherence among medicare part D beneficiaries with and without the low-income supplement

The association between the Medicare Part D low-income subsidy (LIS), gap coverage, and outcomes such as medical expenditures, prescription fills, and medication adherence is not well understood. The purpose of this study was to examine the relationship between the LIS and these measures for patients within a large, national Part D plan in the United States. In this cross-sectional, retrospective analysis, we compared total and plan expenditures, out-of-pocket costs, and medication fills and adherence for three categories of Medicare beneficiaries: non-LIS beneficiaries without gap coverage (non-LIS/non-GC), non-LIS beneficiaries with gap coverage (non-LIS/GC), and LIS beneficiaries (LIS). LIS beneficiaries, relative to non-LIS/non-GC and non-LIS/GC beneficiaries, had higher total expenditures ($1,887 vs. $1,360 vs. $1,341); lower out-of-pocket costs ($148 vs. $546 vs. $570); more expenditures exceeding the gap threshold (27.6% vs. 18.4% vs. 16.9%); and slightly higher adherence to blood pressure (65.6% vs. 64.2% vs. 62.4%); diabetes (62.5% vs. 57.7 vs. 57.4%); and lipid-lowering (59.6% vs. 57.0 vs. 55.6%) medications. LIS beneficiaries had higher total expenditures, lower out-of-pocket costs, and modestly better adherence to diabetes medications than non-LIS/non-GC and non-LIS/GC beneficiaries.
Wheat Effect on Frost‐Seeded Red Clover Cultivar Establishment and Yield

Frost-seeding red clover (Trifolium pratense L.) into winter cereals is a cost effective establishment method. Abiotic effects on seedling establishment have been reported, but information on cultivar differences is lacking. The objectives of this study were to quantify the effect of winter wheat (Triticum aestivum L.) on the establishment, persistence, and forage dry matter (DM) production of 15 red clover cultivars of diverse origin. Cultivars were frost-seeded near Ames, IA in March of 2003 and 2004 and Prairie du Sac, WI in 2004. Presence of the wheat crop caused 19 and 23% mortality in 2003 and 2004 compared with the no-wheat treatment in Iowa and 51% mortality in 2004 in Wisconsin. Dry matter yield of diploid cultivars exceeded tetraploids in all environments (439 vs. 559 g m -2 ). Favorable conditions for germination and emergence in 2003 resulted in high plant densities and no relationship between post-wheat red clover density and DM yield. In 2004, unfavorable environmental conditions reduced plant densities, creating a relationship between red clover density (x) and DM yield (y) (y = 305 + 8.86x, R 2 = 0.65 in Iowa; y = 382 + 3.83x, R 2 = 0.22 in Wisconsin). The southern cultivar Cherokee generally had greater performance than the average northern cultivar. Differences across years and locations were inconsistent for elite and land races. Within different origins and selection histories, large variability exists in cultivar performance. More data are needed to determine if the cultivar-by-wheat interaction is important for screening cultivars for dual grain/forage systems.
Goodman’s “New Riddle”

First, a brief historical trace of the developments in confirmation theory leading up to Goodman’s infamous “grue” paradox is presented. Then, Goodman’s argument is analyzed from both Hempelian and Bayesian perspectives. A guiding analogy is drawn between certain arguments against classical deductive logic, and Goodman’s “grue” argument against classical inductive logic. The upshot of this analogy is that the “New Riddle” is not as vexing as many commentators have claimed (especially, from a Bayesian inductive-logical point of view). Specifically, the analogy reveals an intimate connection between Goodman’s problem, and the “problem of old evidence”. Several other novel aspects of Goodman’s argument are also discussed (mainly, from a Bayesian perspective).
Divergent mechanisms of action of the inflammatory cytokines interleukin 1‐β and tumour necrosis factor‐α in mouse cremasteric venules

1. Protein synthesis dependency and the role of endogenously generated platelet activating factor (PAF) and leukotriene B(4) (LTB(4)) in leukocyte migration through interleukin-1beta (IL-1beta)- and tumour necrosis factor-alpha (TNFalpha)-stimulated mouse cremasteric venules was investigated using established pharmacological interventions and the technique of intravital microscopy. 2. Based on previously obtained dose-response data, 30 ng rmIL-1beta and 300 ng rmTNFalpha were injected intrascrotally (4 h test period) to induce comparable levels of leukocyte firm adhesion and transmigration in mouse cremasteric venules. 3. Co-injection of the mRNA synthesis inhibitor, actinomycin D (0.2 mg kg(-1)), with the cytokines significantly inhibited firm adhesion (49+/-13.6%) and transmigration (67.2+/-4.2%) induced by IL-1beta, but not TNFalpha. 4. In vitro, TNFalpha (1-100 ng ml(-1)), but not IL-1beta, stimulated L-selectin shedding and increased beta(2) integrin expression on mouse neutrophils, as quantified by flow cytometry. 5. The PAF receptor antagonist, UK-74,505 (modipafant, 0.5 mg kg(-1), i.v.), had no effect on adhesion induced by either cytokine, but significantly inhibited transmigration induced by IL-1beta (66.5+/-4.5%). 6. The LTB(4) receptor antagonist, CP-105,696 (100 mg kg(-1), p.o.), significantly inhibited both IL-1beta induced adhesion (81.4+/-15.2%) and transmigration (58.7+/-7.2%), but had no effect on responses elicited by TNFalpha. Combined administration of the two antagonists had no enhanced inhibitory effects on responses induced by either cytokine. 7. The data indicate that firm adhesion and transmigration in mouse cremasteric venules stimulated by IL-1beta, but not TNFalpha, is protein synthesis dependent and mediated by endogenous generation of PAF and LTB(4). Additionally, TNFalpha but not IL-1beta, can directly stimulate mouse neutrophils in vitro. The findings provide further evidence to suggest divergent mechanisms of actions of IL-1beta and TNFalpha, two cytokines often considered to act via common molecular/cellular pathways.
Viscosity, yield stress, slip, and natural convection of HSPAN gel-water dispersions

Three hydrolyzed-starch–polyacrylonitrile (HSPAN) copolymer materials tested as gel–water dispersions in a Brookfield rotating spindle viscometer exhibited velocity slip at solid boundaries and a yield stress. Dispersions with 0.5% HSPAN concentrations were about 20,000 times more viscous than water when the shear stress surpassed the yield stress and viscous power-law flow ensued. The apparent viscosity of an HSPAN gel–water dispersion was reduced by nearly an order of magnitude when tap water was substituted for deionized water. The apparent viscosity of the HSPAN gel–water dispersions decreased by about 30% after the fluid was continuously maintained at a temperature of 80°C for 1 week, and by an order of magnitude or more after 3 weeks under those conditions. In natural convection tests, the yield stress enabled an HSPAN gel–water dispersion to withstand greater temperature differences across a horizontal layer before inception of natural convection than a fluid without one. © 1993 John Wiley & Sons, Inc.
Examining the Effects of Stress and Campus Climate on the Persistence of Students of Color and White Students: An Application of Bean and Eaton's Psychological Model of Retention.

The current study examined the effects of stress and campus climate perceptions on the persistence decisions of students of color and White students using Bean and Eaton’s (2000) Psychological Model of College Student Retention. A sample of first-year students (N = 1,491) at a predominantly White research university were survey enduring their second semester and their enrollment status was subsequently tracked after 2 years. Path analysis was conducted on the sample of students of color (n = 548) and White students (n = 943). Results indicated models that explained 27 % of the variance for students of color and 44 % of the variance for White students in persistence after 2 years of college. Among the initial 37 variables included in the models, 17 had significant direct and indirect effects on students’ of color persistence including observing racism on campus, having comfortable academic interactions, stress related to the academic environment, and feelings about the campus environment. For White students, 13 variables had significant direct and indirect effects on persistence, including having opportunities for diverse peer interactions and comfortable academic interactions, stress related to the social environment on campus, and feelings about the campus environment. The discussion highlights the usefulness of the Bean and Eaton model for examining retention for students of color and White students.
Computed tomographic angiography in pediatric blunt traumatic vascular injury

Pediatric vascular injuries are rare but can be difficult to diagnose and challenging to manage. We present our experience with computed tomographic angiography in 3 pediatric patients with vascular injuries secondary to blunt trauma. Computed tomographic angiography is noninvasive, fast, rapidly available in most centers, and can evaluate for other injuries. We present a review of the literature and recommend computed tomographic angiography as the diagnostic tool of choice in the evaluation of pediatric blunt vascular trauma.
Discriminative stimulus properties of atypical and typical antipsychotic drugs: a review of preclinical studies

Background Drug discrimination is an increasingly valuable behavioral assay for the preclinical development of antipsychotic drugs. The majority of studies have used the atypical antipsychotic clozapine because it displays robust discriminative stimulus properties and is the “prototypical” or “gold standard” atypical antipsychotic against which other antipsychotics will undoubtedly be compared for many years.
Spatial grids for hurricane climate research

The authors demonstrate a spatial framework for studying hurricane climatology. The framework consists of a spatial tessellation of the hurricane basin using equal-area hexagons. The hexagons are efficient at covering hurricane tracks and provide a scaffolding to combine attribute data from tropical cyclones with spatial climate data. The framework’s utility is demonstrated using examples from recent hurricane seasons. Seasons that have similar tracks are quantitatively assessed and grouped. Regional cyclone frequency and intensity variations are mapped. A geographically-weighted regression of cyclone intensity on sea-surface temperature emphasizes the importance of a warm ocean in the intensification of cyclones over regions where the heat content is greatest. The largest differences between model predictions and observations occur near the coast. The authors suggest the framework is ideally suited for comparing tropical cyclones generated from different numerical simulations.
Cyclic deformation and fracture in Pb-Sn solid solution alloy

The cyclic deformation behavior of Pb-2 pct Sn solid solution alloy has been investigated. Results indicate that grain boundary migration and sliding occur in a systematic manner, giving rise to a series of migration markings on the surface of deformed specimens. Extensive cracking and cavitation takes place at migrating boundaries leaving an array of microcavities at high strain amplitudes. This feature was not observed at the low strain amplitudes investigated. Dynamic recrystallization and the evolution of a diamond grain configuration from an initial random distribution of grains were observed. These microstructural observations are discussed in relation to their influence on high temperature fatigue fracture.
A comparison of the labile disulfide bonds of rabbit γG-immunoglobulin fragments

Abstract The Fab fragment from insoluble papain digestion and mild reduction of rabbit γG-immunoglobulin was compared with the F(ab′) 2 fragment from peptic digestion of γG. Insoluble papain digestion of F(ab′) 2 , when preceded or followed by mild reduction and alkylation with iodoacetic acid-1- 14 C, results in the liberation of S -carboxymethylcysteine (CMC)-peptides containing a total of slightly more than one mole of CMC per Fab fragment formed. Fab has less proline and less leucine than Fab′. On mild reduction and alkylation, Fab has a lower content of CMC than either Fab′ or γG per half molecule. These data lend quantitative support to the hypothesis that papain and pepsin may split on opposite sides of a disulfide bond between the heavy chains of rabbit γG.
Two-part wage structures

According to the monopsony model, a firm facing an imperfectly competitive labor market will hire an amount of labor such that the marginal revenue product will equal the marginal factor cost. However, if the firm can use a twopart wage structure, the result is substantially different, to the benefit of both firm and employees. This article develops the theory of a two-part wage structure, which is the labor market analogue of a two-part tariff. A two-part wage structure arises whenever the employment transaction between a firm and its workers involves a payment by the worker to the firm upon beginning employment and a payment by the firm to the worker each period thereafter for labor received. As with two-part tariffs, there are circumstances under which an ideal result holds: even in imperfectly competitive labor markets, firms would pay a wage equal to the marginal revenue product (and receive all gains from the market situation through the workers' initial payments to the firm). Two-part tariffs arise in many economic contexts [1, 2, 3, 4, 5]. For example, W. Oi [5] has examined the pricing problem of an amusement park which sells admission tickets and ride tickets in imperfect competition. The standard twopart tariff result holds for the amusement park: it charges a group of identical consumers a price on rides equal to the marginal cost, and collects all profits from imperfect competition through the lump-sum admission fee. This solution maximizes park profits since the admission fee does not distort the consumer's choice between rides and other goods. The maximum consumer's surplus is extracted with this two-part tariff.
Transport Function of Rice Amino Acid Permeases (AAPs)

The transport function of four rice (Oryza sativa) amino acid permeases (AAPs), OsAAP1 (Os07g04180), OsAAP3 (Os06g36180), OsAAP7 (Os05g34980) and OsAAP16 (Os12g08090), was analyzed by expression in Xenopus laevis oocytes and electrophysiology. OsAAP1, OsAAP7 and OsAAP16 functioned, similarly to Arabidopsis AAPs, as general amino acid permeases. OsAAP3 had a distinct substrate specificity compared with other rice or Arabidopsis AAPs. OsAAP3 transported the basic amino acids lysine and arginine well but selected against aromatic amino acids. The transport of basic amino acids was further analyzed for OsAAP1 and OsAAP3, and the results support the transport of both neutral and positively charged forms of basic amino acids by the rice AAPs. Cellular localization using the tandem enhanced green fluorescent protein (EGFP)-red fluorescent protein (RFP) reporter pHusion showed that OsAAP1 and OsAAP3 localized to the plasma membrane after transient expression in onion epidermal cells or stable expression in Arabidopsis.
Analyzing solar energy policies using a three-tier model: A case study of photovoltaics adoption in Arizona, United States

Abstract This study reveals the interrelationships among a variety of policies supporting solar energy adoption in the U.S. and then calculates the amount of financial subsidies required to support mandatory policies such as Renewable Portfolio Standard (RPS). To illuminate interrelationships among these policies, this study proposes three tiers of descriptive model: the top tier includes mandatory policies such as the Renewable Portfolio Standard (RPS); the middle tier is composed of financial support mechanisms, such as tax credit and rebates; and the bottom tier comprises policies that provide funding sources, such as Public Benefit funds. Based on our proposed model, this study further builds a model which calculates the amount of financial subsidies required to support RPS targets of distributed photovoltaics (PV) adoption. The model is applied to the case study of residential PV adoption in the state of Arizona by 2025. The financial requirements are calculated considering of the uncertainty of federal tax credits (extension or termination after 2016) and compared with planned funds that support PV adoption. This study points out that if states would pursue a sustainable PV adoption targets, they should make more efforts on financial support programs.
Children in Research: The Experiences of Siblings in Research Is a Family Affair:

The specific aims of this study were to (a) ascertain siblings’ ethical concerns, process, and meaning of their brother’s or sister’s involvement in clinical research; (b) describe siblings’ understanding of the research in which their brother/sister was involved; (c) explore siblings’ perception of sociocultural influences on their brother’s/sister’s willingness to participate in research; and (d) describe how siblings are affected by their brother’s/sister’s research trial. Nineteen siblings (ages 9 to 21) whose brother or sister had been enrolled in a clinical research trial within the past 6 months were interviewed, and the data were analyzed qualitatively. A sibling’s understanding of the clinical research trial was distinctly different depending on his or her developmental age and the illness of the brother/sister. These differences included the invasiveness of procedures, seriousness of condition, and the need for siblings to actually participate in the clinical research treatment.
Inpatient Radiology Utilization: Trends over the Past Decade

OBJECTIVE. The objective of our study was to assess patterns of use of radiology services for inpatients at our institution between 1993 and 2002.MATERIALS AND METHODS. We retrospectively reviewed the administrative data about adult inpatients for fiscal years 1993-2002 in a 721-bed tertiary care institution. Examinations were coded according to imaging technique: conventional (plain films and fluoroscopy), sonography, nuclear medicine, CT, or MRI. We assessed workload trends using relative value units (RVUs). Linear regression analysis was used to assess the significance of trends for the number of examinations and RVUs per case-mix-adjusted admission (CMAA).RESULTS. There was a significant decrease in the total number of examinations per CMAA (p < 0.001). This was due to significant decreases in the use of conventional studies (p < 0.001) and sonograms (p < 0.001), despite significant increases in the number of nuclear medicine (p = 0.046), CT (p < 0.001), and MRI (p < 0.002) examinations per CMAA. The ...
Quantifying dominance of adult female white-tailed deer in the presence of abundant food

Dominance is a behavioural mechanism that allows individuals to access and monopolize resources which should ultimately improve their fitness. Hierarchy strength should be strongest when resources are limited; however, this relationship is not consistent. We provided abundant food to assess whether hierarchy strength was consistent with resource abundance using 9 groups of captive female white-tailed deer (Odocoileus virginianus). We further assessed how body mass, age and testosterone levels were associated with rank position. Deer displayed a weak hierarchy with a mean linearity ( h ′ ) of 0.39 (SD = 0.09) and a mean directional consistency index of 0.83 (SD = 0.06). Rank was related to body mass ( p = 0 . 004 , slope = 0.011), but not age or testosterone levels ( p ⩾ 0 . 163 ). We demonstrate that hierarchy strength was weak in the presence of abundant food resources and suggest the possibility that dominance is a plastic behaviour that may vary with resource abundance.
Design and precision construction of novel magnetic-levitation-based multi-axis nanoscale positioning systems

Abstract This paper presents two novel six-axis magnetic-levitation (maglev) stages capable of nanoscale positioning. These stages have very simple and compact structures, which is advantageous to meet the demanding positioning requirements of next-generation nanomanipulation and nanomanufacturing. Six-axis motion generation is accomplished by the minimum number of actuators and sensors. The first-generation maglev stage, namely the Δ-stage, is capable of generating translation of 300 μm and demonstrates position resolution better than 2 nm root-mean-square (rms). The second-generation maglev stage, namely the Y-stage, is capable of positioning at a resolution better than 3 nm rms over a planar travel range of 5 mm × 5 mm. A novel actuation scheme was developed for the compact structure of this stage that enables six-axis force generation with just three permanent-magnet pieces. This paper focuses on the design and precision construction of the actuator units, the moving platens, and the stationary base plates. The performance of the two precision positioners is compared in terms of their positioning and load-carrying capabilities and ease of manufacture. Control system design for the two positioners is discussed and an experimental plant transfer function model is presented for the Y-stage. The superiority of the developed instruments is also demonstrated over other prevailing precision positioning systems in terms of the travel range, resolution, and dynamic range. The potential applications of the maglev positioners include semiconductor manufacturing, microfabrication and assembly, nanoscale profiling, and nanoindentation.
Baclofen: what's in a word? A world of difference.

Dear Editor, The paper by Addolorato et al . (2011) attributes to me and to Dr William Bucknam a hypothesis that neither of us has advanced. Addolorato et al . write: ‘However, anecdotal reports have hypothesized the ability of high doses of baclofen (up to 140 and 270 mg/day) to reduce alcohol craving and consumption (Ameisen, 2005a; Bucknam, 2007)’. My 2005 paper and Bucknam's (2007) paper expressly advance a very different hypothesis, that baclofen at higher doses can suppress , …
Disorganizing and Reorganizing Conflict: Outcomes of the State's Legal Regulation of the Strike since the Wagner Act

Aux Etats-Unis, de nombreuses etudes privilegient la notion d'autonomie de l'Etat par rapport aux acteurs sociaux. L'A. etudie l'impact de l'Etat en matiere de conflits sociaux du travail. La loi Wagner de 1935, puis la loi Taft-Hartley de 1947 sont examinees notamment en ce qui concerne la gestion des mouvements de greves. Trois theories de l'Etat sont confrontees : la theorie structuraliste, la theorie de la classe politique et la theorie de l'Etat centralise. Cette derniere n'offre que peu de perspectives, tandis que les deux autres, plus fecondes, s'averent complementaires
The Crossover Effects of Supervisor Work-Family Positive Spillover on Employee Sleep Deficiency: Moderating Effects of Family Supportive Supervisor Behaviors (FSSB)

The majority of literature on the work-family interface has focused on, and provided evidence of, the conflict associated with engagement in both work and family roles (Eby, Casper, Lockwood, Bordeaux, & Brinley, 2005). Research examining the positive aspects of work and family participation remains limited. The current study investigated how work-family positive spillover is transferred between members of the supervisoremployee dyad and subsequently how this affects employee sleep outcomes. It was hypothesized that work-to-family affective positive spillover experienced by supervisors would crossover to employees and increase their experiences of work-to-family affective positive spillover. In turn, this would allow for better employee sleep. It was also proposed that these relationships would depend on the level of employee perceptions of family-supportive supervisor behaviors (FSSB), such that higher levels of FSSB would result in higher levels of employee positive spillover and better employee sleep. As part of a larger study, survey data were collected in a sample of 696 workers supervised by 180 managers in the information technology sector. Contrary to expectations, results indicated that supervisor positive spillover was negatively related to employee positive spillover. Furthermore, FSSB moderated the association between supervisor positive spillover and employee sleep duration, such that the relationship between supervisor positive spillover and employee sleep duration was positive under high levels of FSSB, but negative under low levels of FSSB. Again, this finding was contrary to expectations. Alternative explanations are discussed. POSITIVE SPILLOVER AND SLEEP ii Acknowledgements I would like to acknowledge my thesis committee for their guidance, suggestions, and enthusiasm. Each member’s expertise has proved extremely valuable in the development of this manuscript. I am especially grateful to my advisor, Dr. Leslie Hammer, for providing me with continual support and assistance over the course of this project. I would also like to thank my cohort for their helpful feedback. Finally, I would like to acknowledge my roommates, friends, and family members for their encouragement and support.
Assessing sustainability for global forests: a proposed pathway to fill critical data gaps

The UN’s Millennium Development Goals (MDGs) and other regional and national policy commitments have motivated an upsurge of interest in concepts and practical methods for monitoring forest conditions and trends at very wide geographic scales. Two approaches to sustainability assessment at a global level are reviewed here. One consists of monitoring change in forest conditions over time—the so-called Criteria and Indicators (C&I) approach. Another approach compares nations at a given point in time. An example is the Yale Environmental Performance Index (EPI). Both approaches yield insights. It is widely recognized, though, that severe data weaknesses afflict forest information over much of the world. These weaknesses include weak or absent information on wood consumption in many regions, poor area estimates, and weak or absent information on key ecological conditions in forests. The purpose of this essay is to introduce these efforts at global assessment, and to argue that an entirely new discipline is needed to supply the information needed. The focus of this new discipline would be to design an ecologically based set of definitions for forest and related ecosystems, and then to build and implement the optimum combination of satellite measurements, air photo interpretation, and field plot measurements needed to measure world forest resource conditions and trends. Examples of this new approach are already appearing. This argument is addressed to members of the global forest policy community concerned with assessment, and to scientists, technologists, and managers in the many technical fields already engaged on one or another aspect of measuring and monitoring forest conditions at a national and regional scale.
The natural history of asymptomatic severe carotid artery stenosis

Background Although level 1 evidence supports carotid endarterectomy (CEA) for stroke prevention in patients with asymptomatic severe carotid artery stenosis (ASCAS; >70%), medical therapy alone has been promulgated by some as equally effective. The goal of this study was to determine the natural history of medically treated patients with ASCAS. Methods Patients with ASCAS from 2005 to 2006 were identified in a health network database. Patients were included if the initial therapeutic plan involved medical therapy alone (usually because of comorbidities or patient preference). Study end points included: ipsilateral neurologic symptoms (INS) of transient ischemic attack and/or stroke, death, and INS and/or death. Results There were 126 carotid arteries identified in 115 patients. Using standard duplex velocity criteria, 88 (70%) had severe (70%-89%) and 38 (30%) had very severe stenoses (VSS; 90%-99%). The average age was 73.5 years, demographic characteristics included: 66% hypertension, 64% coronary artery disease, 30% diabetes, 5% chronic kidney disease (CKD), and 86% were taking a statin drug (28% had a low-density lipoprotein level P = .002), CKD (HR, 6.25; 95% CI, 2.05-19.2; P = .001), and age (HR, 0.94; 95% CI, 0.91-0.98; P = .001). There were 41 patients (33%) who underwent eventual carotid revascularization (32 CEA, nine stent); 23 of 41 (56%) were performed for INS and 18 (44%) for plaque progression. Overall 5-year actuarial survival was 69.8% ± 4.1%. Multivariate predictors of death included: age (HR, 1.06; 95% CI, 1.03-1.1; P = .0001), chronic obstructive pulmonary disease (HR, 1.92; 95% CI, 1.08-3.41; P = .03), and diabetes (HR, 5.08; 95% CI, 2.86-9.01; P P = .006), CKD (HR, 5.46; 95% CI, 2.12-14.08; P = .0004), and diabetes (HR, 2.6; 95% CI, 1.59-4.24; P = .0001). Statin use was not protective against INS or death in this cohort. Conclusions Medically managed patients with ASCAS develop INS early, especially in patients with VSS. Medical therapy with aspirin and statins failed to control ASCAS, thus validating the role of CEA in these patients as promulgated in multiple current treatment guidelines.
Temporal Polyethism and Worker Specialization in the Wasp, Vespula germanica

Temporal polyethism is a common mechanism of worker specialization observed in social insect species with large colony sizes, Vespula wasp colonies consist of thousands of monomorphic workers, yet studies based on small cohorts of workers report that temporal polyethism is either weak or completely absent in different Vespula species. Concerned that the small sample size of these studies precluded detection of temporal polyethism, several hundred, known-age Vespula germanica (F.) (Hymenoptera: Vespidae) workers were studied. High variability was found in the sequence and diversity of tasks workers perform, suggesting that V. germanica colonies exhibit weak temporal polyethism. The most common order in which tasks were taken up was 1) nest work, 2) pulp foraging, 3) carbohydrate foraging, and 4) protein foraging. However, only 61% of the wasps performed more than two of the tasks during their lives. Thorax size had a significant negative effect on the age at first foraging, but the magnitude of the effect was small. The daily ratio of task generalists to specialists was relatively constant despite the high turnover of workers, growth of the colony, and the colony's transition from rearing worker larvae to rearing reproductives. Over the course of their lives, 43% of the workers averaged more than one kind of task performed per day. Life history traits are identified that may explain why vespines with large colonies use a generalist strategy of labor division rather than the specialist strategy observed in honey bees (Apis mellifera) and large colonies of wasps (Polybia occidentalis).
On the relationship between recognition familiarity and perceptual fluency: Evidence for distinct mnemonic processes

Abstract Fluent reprocessing of perceptual aspects of recently experienced stimuli is thought to support repetition priming effects on implicit perceptual memory tests. Although behavioral and neuropsychological dissociations demonstrate that separable mnemonic processes and neural substrates mediate implicit and explicit test performance, dual-process theories of memory posit that explicit recognition memory judgments may be based on familiarity derived from the same perceptual fluency that yields perceptual priming. Here we consider the relationship between familiarity-based recognition memory and implicit perceptual memory. A select review of the literature demonstrates that the fluency supporting implicit perceptual memory is functionally and anatomically distinct from that supporting recognition memory. In contrast to perceptual fluency, recognition familiarity is more sensitive to conceptual than to perceptual processing, and does not depend on modality-specific sensory cortices. Alternative possible relationships between familiarity in explicit memory and fluency in implicit memory are discussed. PsycINFO classification: 2343
A study on mode of antifeedant effects of epilimonol against Leptinotarsa decemlineata

Colorado potato beetle, Leptinotarsa decemlineata (Say), neonate larvae and adults were bioassayed with the antifeedant epilimonol. Three-day exposure of neonate larvae resulted in increasing delays in development (appearance of 4th instars) corresponding to increasing dosages. At a dosage of 20 μg/cm2, development was delayed by about 40% without other detrimental effects. Mouthpart coating of adult beetles with epilimonol emulsion resulted in significant feeding reductions, while injection of epilimonol into the haemolymph of female adults did not elicit significant feeding reduction or oviposition suppression. The results indicated that epilimonol did not elicit significant internal toxicity, and feeding reductions were most likely exerted by action on chemoreceptors on mouthparts or in the preoral cavity.
Predicting the types of file fragments

A problem that arises in computer forensics is to determine the type of a file fragment. An extension to the file name indicating the type is stored in the disk directory, but when a file is deleted, the entry for the file in the directory may be overwritten. This problem is easily solved when the fragment includes the initial header, which contains explicit type-identifying information, but it is more difficult to determine the type of a fragment from the middle of a file. We investigate two algorithms for predicting the type of a fragment: one based on Fisher's linear discriminant and the other based on longest common subsequences of the fragment with various sets of test files. We test the ability of the algorithms to predict a variety of common file types. Algorithms of this kind may be useful in designing the next generation of file-carvers - programs that reconstruct files when directory information is lost or deleted. These methods may also be useful in designing virus scanners, firewalls and search engines to find files that are similar to a given file.
Symbolic Execution of Virtual Devices

Device drivers are a principal source of failures in computer systems. Therefore, improving driver reliability greatly improves overall system reliability. However, driver development largely has to wait until a first stable version of the device becomes available. This dependency often leaves not enough time for driver validation. Recently, virtual machines and virtual devices have found their way into early driver development and validation. Virtual devices enable driver development even before real devices become available and bring complete observability and trace ability that evade real devices. We present an approach to static analysis of virtual devices which is central to achieving observability and traceability. This approach exercises the device model of a virtual device by symbolic execution. Based on the result of symbolic execution, a concrete test case is generated for each path through the device model, which has been exercised. We have applied this approach to virtual devices of five network adapters. The results show that this approach is feasible, efficient, and useful.
Research Note: Nonlinear time series analysis of northern and southern solar hemisphere daily sunspot numbers in search of short-term chaotic behavior

Daily sunspot number data for the northern and southern solar hemispheres from 22 cycle maximum to the current cycle 23 maximum are analyzed using nonlinear time series methods in an eort to identify chaotic behavior on short time scales as indicated by the recent helioseismic observations. We nd that separate analyses of north and south solar hemisphere data provide more consistent results. Dierent behavior at maxima and minimum are observed. The maximum sections have a region that bears the marks of self-similarity whereas the minimum shows no such behavior. However, it is the minimum data that determine the results for the correlation dimension over one cycle. Thus, over many cycles, minima mask the potentially self-similar sections at maximum; access to information on whether the solar cycle is chaotic long-term is severely limited, if not precluded. To make sure the results were not aected by noise, the method of artifactual correlations was used to investigate the noise content of the data, indicating that both the north and south data sets were relatively free of additive noise.
Correlates of Retention for African-American Males in Community Colleges:

The retention rates of African-American men in community colleges are among the lowest of all ethnic groups nationally. This study analyzes organizational data for three cohorts of men in a longitudinal design for three semesters (N = 202), and uses logistic regression to identify the factors that best predict retention. The importance of high school grades, age, number of courses, a positive view of personal skills, clear high goals, and the early identification of a college major appear to be salient for this group and offer implications for practice.
Regional adrenergic regulation of ion transport across the isolated porcine gallbladder

The regional transport properties of the porcine gallbladder epithelium were studied using Ussing chambers in which tissues were bathed in porcine Ringer solution. Under basal conditions, tissues from the neck absorbed Na and Cl. Fundic tissues also absorbed Na, but net Cl transport was not different from zero. Serosal norepinephrine (NE; 0.1 microM) stimulated Na and Cl absorption in the neck but only Cl absorption in the fundus. The effects of NE on Na and Cl transport were blocked by pretreatment with yohimbine, suggesting that alpha 2-adrenoceptors mediate the transport-related actions of this neurotransmitter. Serosal isoproterenol (0.1 microM) produced a tetrodotoxin-insensitive, propranolol-sensitive increase in the short-circuit current (Isc) in fundic tissues but not in tissues from the neck. The beta 2-adrenergic agonist salbutamol produced a response similar to that of isoproterenol. However, the beta 1-adrenergic agonist dobutamine had no effect. Isoproterenol was 5.8-fold more potent than salbutamol in increasing the Isc. A possible explanation for the regional effects of beta-agonists is that beta-adrenoceptors are localized to epithelial cells in the fundic region. These results and results obtained previously suggest regional differences in basal Na and Cl transport across the porcine gallbladder epithelium and that both alpha 2- and beta 2-adrenoceptors act to regulate ion transport in this tissue.
THE EFFICACY AND SAFETY OF CANGRELOR WITH AND WITHOUT GLYCOPROTEIN IIB/IIIA INHIBITORS IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: A POOLED ANALYSIS OF THE CHAMPION TRIALS

Cangrelor, an intravenous, reversible P2Y12 antagonist, was recently approved for use in patients undergoing percutaneous coronary intervention (PCI) in the US. We evaluated the efficacy and safety of cangrelor compared with clopidogrel in the subgroup who received glycoprotein IIb/IIIa inhibitors
Abstract 5215: EZH2-mediated STAT3 activation in glioblastoma

Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor despite maximal therapy. Recent studies suggest that GBMs contain highly tumorigenic, stem cell-like cells termed glioblastoma stem cells (GSCs). GSCs significantly contribute to tumor propagation and treatment resistance and thus are critical target for curative therapy in GBMs. These GSCs share a key characteristic of normal stem cells, such as unlimited self-renewal capacity. Maintenance of the stem cell status in normal stem cells is governed by the Polycomb Repressive Complex 2 (PRC2)-mediated transcriptional repression. Enhancer of zeste homolog 2 (EZH2) is the only catalytically active component in PRC2, and it methylates a specific lysine residue of histone 3, resulting in the repressive chromatin structure. Signal transducer and activator of transcription 3 (STAT3) regulates diverse cellular processes and is frequently activated during tumorigenesis. Components of PRC2 are highly expressed in various cancers including GBMs and STAT3 is required for GSCs maintenance. In this study, we investigated the functional interaction between these two oncogenic pathways regulating GSCs phenotype. We show that targeted pharmacologic disruption of EZH2 by the S-adenosylhomocysteine hydrolase inhibitor called 3-deazaneplanocin A (DZNep), or its specific downregulation by short hairpin RNA (shRNA) inhibits STAT3 activity. Furthermore, AKT-mediated EZH2 phosphorylation affects STAT3 activity through STAT3 methylation. We demonstrate that STAT3 bind to EZH2 promoter and inhibition of STAT3 activity by small molecule inhibitor decrease PRC2 protein expression. Targeting of EZH2 and STAT3 by combined treatment with DZNep and STAT3 inhibitor strongly impairs GSCs self-renewal in vitro and decreases markers of neural stem cell multipotency. In addition, shEZH2 transduction + STAT3 inhibitor treatment extend survival of SCID mice with intracranial GSCs than shEZH2 single transduced group. Together, these obtained results strongly suggest the presence of positive feedback activation loop between PRC2 and STAT3 signaling in GSCs and targeting of this activation loop may offer an attractive therapeutic strategy for GBM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5215. doi:1538-7445.AM2012-5215