cssi/SciSciGPT-SciSciNet huggingface dataset:
Clarifying the role of pain tolerance in suicidal capability

article i nfo Joiner's (2005) interpersonal-psychological theory of suicide hypothesizes that painful and provocative events increase pain tolerance. The theory further proposes that increased pain tolerance represents one component of increased suicidal capability. Although initial studies have been consistent with this model, several key aspects remain untested. In 67 undergraduates, we investigated associations among painful and provocative events, nonsuicidal self-injury, acquired capability for suicide, and pain tolerance, threshold, and perceived intensity. Results were highly consistent with the interpersonal-psychological theory: a multiple mediation model specified that pain tolerance - but not other pain variables - accounted for significant variance within the association between painful and provocative events and acquired capability for suicide. These results held even when the pain tolerance item was removed from the suicidal capability questionnaire. Results also supported the interpersonal-psychological theory hypothesis that nonsuicidal self-injury represents an important painful and provocative event that increases suicidal capability. Specifically, participants with a history of nonsuicidal self-injury displayed increased suicidal capability and decreased pain perception. Overall, these results indicate that pain tolerance plays an important and specific role in suicidal capability.
Observations of the diurnal variation of nitrogen dioxide in the stratosphere

Observations of NO2 from the limb infrared monitor of the stratosphere (LIMS) experiment in high-latitude summer are presented. Appropriate selection of latitude and days during the month of May yields NO2 observations obtained during the afternoon and evening at solar zenith angles ranging from about 35-110 deg. These data show that the NO2 abundances in the stratosphere become strongly dependent on the solar zenith angle for angles exceeding about 80 deg. Model calculations and other observations suggest that from about 80-95 deg this dependence probably reflects variations in the propagation of the visible radiation that photodissociates NO2. The data obtained at zenith angles greater than about 95 deg provide clear evidence for the night decay of NO2 to form N2O5, and the observed decay rate is shown to be consistent with present theory.
Test Procedure for Detectors with Resistance Coupled Output

This paper presents a simple circuit for use primarily in determining the response, to modulation, of a detector with resistance coupled output Only d-c, 60-cycle a-c, and the corresponding meters are used. The theory of operation of the circuit is briefly explained: This theory neglects the effects of capacity reactances at modulation frequencies but not at carrier frequencies. Sample curves obtained by this method show marked differences between the positive and negative peak values of the audio output of the detector with high percentage modulation of the carrier.
Contact, Repellency and Ovicidal Effects of Four Lamiaceae Plant Essential Oils against Tetranychus urticae Koch (Acari: Tetranychidae)

Tetranychus urticae Koch (Acari: Tetranychidae) is an important pests in the world. Many plant essential oils show a broad spectrum of activity against pests. The usage of essential oils in two spotted spider mite control is seen as an alternative to pesticides. This study investigated the contact and repellency effects of Lavandula x intermedia Emeric ex Loisel., Salvia officinalis L., Rosmarinus officinalis L. and Hyssopus officinalis L. essential oils on Tetranychus urticae. The chemical composition of the four essential oils was characterized by GC-MS. In this study, 1, 5, 10 and 20 ml/l concentrations of essential oils were used to conduct adult and nymph period applications on two spotted spider mite through leaf disc-spray tower method. In addition, the ovicidal effect of essential oils on Tetranychus urticae eggs was evaluated. It was found that in all concentrations of the essential oils of lavandin, sage, rosemary and hyssop essential oils had high contact effect on T. urticae adults and nymphs ...
Legal Standards for Establishing Concealment: A Theoretical Framework for Statistical Analysis

This article demonstrates a technique linguists can use to objectively determine a speaker’s intent to conceal. The article reviews the theoretical foundation for classifying reference forms in wiretapped data. After classifying data obtained from a criminal trial that involves speakers from a drug cartel, the article presents simple statistics to support the argument that a speaker’s intent to conceal can be objectively determined, provided a larger study is undertaken to set statistical standards as reference points. The article contains an outline on how to conduct this study.
Distributed path planning for connectivity under uncertainty by ant colony optimization

Movement and allocation of network resources for a system of communicating agents are usually optimized independently. Path planning under kinematic restrictions and obstacle avoidance provides a set of paths for the agents, and given the paths, it is then the job of network design algorithms to allocate communication resources to ensure a satisfactory rate of information exchange. In this paper, we consider the multiobjective problem of path planning for the sometimes conflicting goals of fast travel time and good network performance. In previous work we considered this problem under the assumption of full knowledge of network topologies and unlimited computational resources. In this paper, nothing is known a priori about topology, information is exchanged between nodes within a connected component of the network, and sources of environment-dependent communication failure can only be approximately estimated through learning. All the planning must be done online in a distributed fashion. We apply ant colony optimization to this problem of planning under uncertain information, and show that significant benefit in network performance can be achieved even under the difficult conditions of the scenario. Furthermore, we show the ability of nodes to quickly learn the communication patterns of the arena, and use this information for improved path planning.
How portable are the metadata standards for scientific data? a proposal for a metadata infrastructure

The one-covers-all approach in current metadata standards for scientific data has serious limitations in keeping up with the ever-growing data. This paper reports the findings from a survey to metadata standards in the scientific data domain and argues for the need for a metadata infrastructure. The survey collected 4400+ unique elements from 16 standards and categorized these elements into 9 categories. Findings from the data included that the highest counts of element occurred in the descriptive category and many of them overlapped with DC elements. This pattern also repeated in the elements co-occurred in different standards. A small number of semantically general elements appeared across the largest numbers of standards while the rest of the element co-occurrences formed a long tail with a wide range of specific semantics. The paper discussed implications of the findings in the context of metadata portability and infrastructure and pointed out that large, complex standards and widely varied naming practices are the major hurdles for building a metadata infrastructure.
Faculty Perceptions Of Resource Constraints In Business Academic Research

Administrators and faculty are grappling with the relative importance of teaching and research by professors in higher education. While various opinions exist, both faculty and administrators will likely agree that research will remain prominent in the near future. Faculty frustration can result from inadequate support for research. A national survey of business school faculty examines support adequacy by type of school. Of the ten categories of research support studied, six are receiving less than adequate support. Administrators who allocate their limited research budgets based on the findings of this study will likely remove many of the obstacles their faculty members face in meeting the research objectives of their institutions.
Age of entry into the labor market and career success: The case of the NFL

The consensus across labor market research in sports and non-sports literature has shown that there is a significant interaction between age, ability, and performance. While this relationship is at the foundation of all acts of production or utility creation, little econometric work exploring the role of precocity in career success can be found in the literature. This study therefore examines the role of precocity on labor market outcomes of elite-level National Football League (NFL) players and, indirectly, assesses the on-field efficacy of the NFL’s age rule. The findings indicate that precocity, as measured by the age of entry into the elite-level professional football labor pool, leads to better career success. That is, the younger a player is when he first enters the NFL labor market; the more successful he is likely to be.
Phosphorylation of serine-167 on the human oestrogen receptor is important for oestrogen response element binding and transcriptional activation

We have studied the role of phosphorylation of the human oestrogen receptor (hOR; otherwise known as hER) at serine-167, which has been identified previously as the major oestrogen-induced phosphorylation site. We have tested transactivation by the hOR in yeast and cell-free transcription assays, and shown that mutation of serine-167 results in a 70% decrease in hOR-dependent transcription. Furthermore we explored the functional significance of phosphorylation at this site by hormone binding and DNA binding. DNA binding affinity was 10-fold lower when serine-167 was changed to alanine in the hOR. Cell-free transcription experiments showed that casein kinase II is the enzyme responsible for oestradiol-dependent phosphorylation of the hOR at serine-167. This suggests that a conformational change of the hOR must occur upon hormone binding that exposes serine-167 to casein kinase II, resulting in transactivation of oestrogen-responsive genes.
Enumeration of VSV particles and a demonstration of their growth kinetics by electron microscopy.

SummaryGrowth curve studies indicate that the m.o.i. plays a major role in the replication and resultant quantity of VSV. Consistent high yields of the virus can be obtained when the m.o.i. is kept at approximately 1. Natural aggregation studies using the count technique indicate that the virus is extruded from the cells in loosely connected chains. The agar sedimentation procedure for counting virus particles can be readily adapted to vesicular stomatitis virus with high efficiency.The author is most grateful for the excellent technical assistance of Mary-Martin Bratcher.
Endometriosis impairs the efficacy of gamete intrafallopian transfer: results of a case-control study.

Objective To determine whether pelvic endometriosis impairs the efficacy of GIFT. Design Matched follow-up study. Setting University-based assisted reproduction program. Participants Patients undergoing GIFT between 1987 and 1991. Cases had a primary diagnosis of endometriosis. Controls had no endometriosis and were matched with cases according to age, number of mature eggs transferred, and sperm grade. Intervention Gamete intrafallopian transfer was performed in all patients in an identical manner independent of their underlying diagnosis. Main Outcome Measures Pregnancy and delivery rates. Results Of 114 laparoscopic egg retrievals performed in the endometriosis group, there were 37 pregnancies (32.5%) and 27 deliveries (23.7%). Of the 214 retrievals in the control group, there were 101 pregnancies (47.2%) and 76 deliveries (35.5%). Mantel-Haenszel estimates of relative risk indicated that endometriosis significantly impaired pregnancy and delivery rates. There was no statistically significant difference in pregnancy rates according to severity of disease among endometriosis cases. There was no statistically significant difference in pregnancy rates according to severity of disease among endometriosis cases. Conclusions Our finding that GIFT pregnancy rates were lower in women with a primary diagnosis of endometriosis than in matched controls suggests that endometriosis is associated with reduced efficacy of GIFT.
Tick-bite paralysis in a six-year-old girl.

(1974). Tick-Bite Paralysis in a Six-Year-Old Girl. Postgraduate Medicine: Vol. 56, No. 4, pp. 187-188.
Modular genetic regulatory networks increase organization during pattern formation

Studies have shown that genetic regulatory networks (GRNs) consist of modules that are densely connected subnetworks that function quasi-autonomously. Modules may be recognized motifs that comprise of two or three genes with particular regulatory functions and connectivity or be purely structural and identified through connection density. It is unclear what evolutionary and developmental advantages modular structure and in particular motifs provide that have led to this enrichment. This study seeks to understand how modules within developmental GRNs influence the complexity of multicellular patterns that emerge from the dynamics of the regulatory networks. We apply an algorithmic complexity to measure the organization of the patterns. A computational study was performed by creating Boolean intracellular networks within a simulated epithelial field of embryonic cells, where each cell contains the same network and communicates with adjacent cells using contact-mediated signaling. Intracellular networks with random connectivity were compared to those with modular connectivity and with motifs. Results show that modularity effects network dynamics and pattern organization significantly. In particular: (1) modular connectivity alone increases complexity in network dynamics and patterns; (2) bistable switch motifs simplify both the pattern and network dynamics; (3) all other motifs with feedback loops increase multicellular pattern complexity while simplifying the network dynamics; (4) negative feedback loops affect the dynamics complexity more significantly than positive feedback loops.
Persuasive Hebrew Exercises: The Wit Of Technology-Enhanced Language Learning

This chapter describes current work by the author to develop learning technology for the Werkgroep Informatica Vrije Universiteit (WIVU) database which Eep Talstra and his Werkgroep Informatica team is building for storage and retrieval of linguistic and textual information on the Hebrew Bible. The work on corpus-based language learning described in the chapter is an initial stage in a larger research project to construct persuasive learning objects and technologies (PLOTs). The chapter traces the development of tools from the early teaching technology in 2004 to the current Ezer Emdros-based Exercise Tool. The chapter introduces the linguistic terminology from the database which is used in learning technology. It explains the structure of a curriculum for teaching Biblical Hebrew from the database for Genesis 1-3, and describes when and where technology-enhanced exercises can be introduced, based on the author's test results and observations from the classroom as well as on focused interviews. Keywords: corpus-based language learning; Eep Talstra; Ezer Emdros-based exercise tool; Genesis; Hebrew Bible; persuasive learning objects and technologies (PLOT); WIVU database
Substrate intergrated E-plane horn antenna

A substrate integrated E-plane horn antenna is proposed in this paper. It is built on a printed circuit board. In order to provide paths for longitudinal current which are required by E-plane type of devices, two copper strips are laid at the middle layer of the antenna along the direction of propagation. Two rows of metal posts are arrayed along the same direction to emulate the vertical walls. Moreover, the horn antenna is loaded with a dielectric slab in order to improve the reflection coefficient.
FRI0375 Clinical Improvement According To Patient Reported Outcomes in Patients with Polymyalgia Rheumatica: A Longitudinal Analysis from Routine Care

Background Several outcomes and clinical response measures have been used in patients with polymyalgia rheumatica (PMR), but there is no consensus about the optimal endpoint for evaluating response to treatment. A PMR activity score has been proposed which includes three patient reported outcomes (PROs) 1 . RAPID3 is an index found on a multidimensional health assessment questionnaire (MDHAQ) only including PROs, which is effective to document improvement not only in RA but also in other rheumatic diseases 2 Objectives To prospectively evaluate the performance of RAPID3 and other PROs included on the MDHAQ to document improvement in clinical status over time in patients with PMR. Methods This study was conducted at an academic rheumatology center at which all patients complete a MDHAQ, which includes 0–10 scores for physical function (FN), pain (PN), and patient global estimate (PATGL), compiled into a 0–30 RAPID3. The MDHAQ also scores fatigue, morning stiffness, self-reported joint counts and demographic data. Data collection included MDHAQ, acute-phase reactants, and prednisone dose. PMR patients with complete data seen between 2010 and 2014 were included. A baseline visit and the most recent visit were compared using paired t-test and McNemar9s test. Spearman correlation analysis for non-normally distributed variables was performed between RAPID3 and ESR and CRP. Results 34 PMR patients seen in routine care were included: 59% were females, 71% Caucasian, and mean age was 71.6 years. The mean duration from a baseline visit to most recent visit was 15.5 months. At initial presentation, RAPID3 was 12.2, FN 2.2, pain 5.3, and PATGL 4.7, fatigue 3.9, and morning stiffness 63.1 minutes; 64.7% of the patients had painful hips, 79.4% had painful shoulders, 73.5% had abnormal ESR, and 70.6% had abnormal CRP. Significant improvement was seen between baseline and last visit in mean level of RAPID3 and all other MDHAQ measures, except fatigue (p Conclusions In patients with PMR, improvement was seen according to PROs included on a self-reported MDHAQ questionnaire in a similar range to ESR and CRP, documenting effective response to prednisone. References Leeb BF, Bird HA. Ann Rheum Dis 2004;63(10):1279–83. Castrejon I, Bergman MJ, Pincus T. J Clin Rheumatol 2013;19:169–74. Disclosure of Interest None declared
Speaking up about traditional and professionalism-related patient safety threats: a national survey of interns and residents.

Background Open communication between healthcare professionals about care concerns, also known as ‘speaking up’, is essential to patient safety. Objective Compare interns9 and residents9 experiences, attitudes and factors associated with speaking up about traditional versus professionalism-related safety threats. Design Anonymous, cross-sectional survey. Setting Six US academic medical centres, 2013–2014. Participants 1800 medical and surgical interns and residents (47% responded). Measurements Attitudes about, barriers and facilitators for, and self-reported experience with speaking up. Likelihood of speaking up and the potential for patient harm in two vignettes. Safety Attitude Questionnaire (SAQ) teamwork and safety scales; and Speaking Up Climate for Patient Safety (SUC-Safe) and Speaking Up Climate for Professionalism (SUC-Prof) scales. Results Respondents more commonly observed unprofessional behaviour (75%, 628/837) than traditional safety threats (49%, 410/837); p Conclusions Interns and residents commonly observed unprofessional behaviour yet were less likely to speak up about it compared with traditional safety threats even when they perceived high potential patient harm. Measuring SUC-Safe, and particularly SUC-Prof, may fill an existing gap in safety culture assessment.
Demonstration of a silicon photonic transceiver for polarization-based discrete variable quantum key distribution

We demonstrate a silicon photonic transceiver circuit to implement polarization encoding/decoding for DV-QKD. The circuit is capable of encoding BB84 states with >30 dB PER and decoding with >20 dB ER.
Quantitative Microbial Risk Assessment for Spray Irrigation of Dairy Manure Based on an Empirical Fate and Transport Model

Background: Spray irrigation for land-applying livestock manure is increasing in the United States as farms become larger and economies of scale make manure irrigation affordable. Human health risks from exposure to zoonotic pathogens aerosolized during manure irrigation are not well understood. Objectives: We aimed to a) estimate human health risks due to aerosolized zoonotic pathogens downwind of spray-irrigated dairy manure; and b) determine which factors (e.g., distance, weather conditions) have the greatest influence on risk estimates. Methods: We sampled downwind air concentrations of manure-borne fecal indicators and zoonotic pathogens during 21 full-scale dairy manure irrigation events at three farms. We fit these data to hierarchical empirical models and used model outputs in a quantitative microbial risk assessment (QMRA) to estimate risk [probability of acute gastrointestinal illness (AGI)] for individuals exposed to spray-irrigated dairy manure containing Campylobacter jejuni, enterohemorrhagic Escherichia coli (EHEC), or Salmonella spp. Results: Median risk estimates from Monte Carlo simulations ranged from 10−5 to 10−2 and decreased with distance from the source. Risk estimates for Salmonella or EHEC-related AGI were most sensitive to the assumed level of pathogen prevalence in dairy manure, while risk estimates for C. jejuni were not sensitive to any single variable. Airborne microbe concentrations were negatively associated with distance and positively associated with wind speed, both of which were retained in models as a significant predictor more often than relative humidity, solar irradiation, or temperature. Conclusions: Our model-based estimates suggest that reducing pathogen prevalence and concentration in source manure would reduce the risk of AGI from exposure to manure irrigation, and that increasing the distance from irrigated manure (i.e., setbacks) and limiting irrigation to times of low wind speed may also reduce risk.
Globalization from Below: Transnational Activists and Protest Networks and It Was Like a Fever: Storytelling in Protest and Politics

Globalization from Below: Transnational Activists and Protest Networks. By Donatella della Porta, Massimiliano Andretta, Lorenzo Mosca, and Herbert Reiter. Minneapolis: University of Minnesota Press, 2006. 300p. $75.00 cloth, $25.00 paper. It Was Like a Fever: Storytelling in Protest and Politics. By Francesca Polletta. Chicago: University of Chicago Press, 2006. 242p. $45.00 cloth, $19.00 paper. While different in scope and intent, both books offer a refreshing and uplifting sense of the capacity and willingness of people to protest conditions in society, or the world, which they deem unjust. The authors may not have set out to highlight idealism in political activism, but they ended up doing so.
Contrast-enhanced ultrasound evaluation of skeletal muscle perfusion in response to left ventricular assist device (LVAD) therapy

Chronic and advanced heart failure patients experience reduced capacity for exercise, likely due to reduced cardiac output and exercise-induced capillary vasodilation. To address these symptoms, clinicians implant a left ventricular assist device (LVAD) to improve physical function for this patient population. However, most LVADs, including the HeartMateII investigated in this study, are designed to provide continuous flow, and cannot respond to exercise-mediated demand for increased blood flow in skeletal muscles. This study investigates whether skeletal muscle perfusion and exercise capacity improved following LVAD implantation using contrast-enhanced ultrasound (CEUS) imaging of the quadriceps muscle. To date, eight patients have enrolled in and completed the CEUS study, and were evaluated prior to LVAD implantation (baseline), 2 weeks after LVAD implantation, and again at 3 months after LVAD implantation. Patients underwent two CEUS exams at each time point, one at a resting muscle state and the other at a muscle fatigue state after completing knee extensor exercises. We observed that patients experienced a reduction in quadriceps muscle area and diameter following LVAD implantation, but were regaining muscle area by approximately 4% by the 3-month postoperative evaluation compared to the 2-week post-operative evaluation (p<0.0001). Additionally, patients experienced approximately 35% increase in muscle strength at the 3-month post-operative evaluation, compared to their baseline assessment (p=0.0033). While there were no significant differences in skeletal muscle perfusion across the three study time points (p=0.0765), we did observe that the time to initial contrast visualization (p < 0.04) and time to peak contrast intensity (p < 0.03) decreased after exercise across all time points, compared to pre-exercise evaluations. LVAD therapy appears to improve physical function in patients with heart failure and reduced cardiac output, and does not appear to diminish exercise-induced blood flow to skeletal muscle. CEUS-estimated muscle perfusion seems to indicate appropriate physical function in patients with LVAD therapy, although more data is required to bolster these preliminary results.
A New Model of Persistent Retail Price Dispersion

Price dispersion persists, even on the Internet where search costs are small. One reason may be that consumers prefer randomized prices to fixed prices, implying that retail price data will always show some degree of price dispersion.
Lung transplantation in idiopathic pulmonary fibrosis.

Introduction: Idiopathic Pulmonary Fibrosis (IPF) is a unique type of interstitial pneumonia in which progressive fibrosis can ultimately result in respiratory failure and death. The median surviva...
Progress in cancer nanotechnology.

Publisher Summary A strict definition of nanotechnology refers to molecular devices smaller than 100 nm, which are, therefore, on the nano scale. One nanometer (nm) is one billionth or 10–9 of a meter. Nanomedicine has emerged as a specific focus in nanotechnology and refers to medical interventions at the molecular scale for curing disease or repairing damaged tissues such as bone, muscle, or nerve. This field combines the expertise of individuals in medicine, mathematics, biology, engineering, chemistry, and computer science for the creation of devices for human application. While many fields are now employing nanomedicine, the major focus remains in oncology. Potential applications involve the ability to specific targeted treatment of cancer and also enhanced ability for the prevention, early diagnosis, and monitoring of oncologic disease progression through superior imaging techniques. According to the National Cancer Institute, nanotechnology will serve as multifunctional tools that will not only be used with any number of diagnostic and therapeutic agents but will change the very foundations of cancer diagnosis, treatment, and prevention. The envisioned multifunctional smart nanodevice would contain the ability to (a) detect cancer at an early stage, (b) enhance imaging to pinpointing tumor location, (c) deliver drugs effective against the tumor, (d) and allow for monitoring of cancer cell eradication.
Involvement of PLP in biological formation iron-sulfur clusters

The nifS gene product is a pyridoxal phosphate binding enzyme which catalyzes the desulfuration of L-cysteine to yield L-alanine and sulfur. This activity is required for the full activation of the two nitrogenase component proteins called Fe protein and MoFe protein. Because both Fe protein and MoFe protein have metalloclusters comprised of metals and inorganic sulfide, we have suggested that NIFS might supply the inorganic sulfide for Fe-S core formation. The mechanism for the desulfurization of L-cysteine catalyzed by NIFS was determined in several ways. The substrate analogs, L-allylglycine and L-vinylglycine, were shown to irreversibly inactivate NIFS by formation of a γ-methylcystathionyl or cystathionyl residue, respectively, through nucleophilic attack by an active site cysteinyl residue on the corresponding pyridoxal phosphate-analog adduct. The reactive cysteinyl residue, which is required for cysteine desulfurization activity, was identified as Cys325 by the specific alkylation of that residue and by site-directed mutagenesis experiments. Also, the formation of an enzyme-bound cysteinyl persulfide was identified as an intermediate in the NIFS-catalyzed reaction. Finally, evidence was obtained for an enamine intermediate in the formation of L-alanine. These results support a mechanism for NIFS-catalyzed desulfurization of L-cysteine which involves formation of a substrate cysteine-pyridoxal phosphate ketimine adduct and subsequent nucleophilic attack by the thiolate anion of Cys325 on the sulfur of the substrate cysteine. This leads to formation of a protein-bound persulfide, which is the proposed sulfur donor in Fe-S core formation, and a pyridoxal phosphate-bound enamine which is ultimately released as L-alanine. Using L-cysteine, ferrous ion, DTT, and MgATP, NIFS is able to catalyze the reactivation of the apo-Fe protein in vitro. The Fe4S4 cluster of the Fe protein reconstituted by NIFS is identical to the native one, as indicated by EPR analysis in the presence or absence of MgATP.
Rasmussen’s Syndrome

Rasmussen’s syndrome is a childhood developing syndrome, usually characterized by refractory focal motor seizures (epilepsia partialis continua). Most cases originate between the age of 1 and 10 years, mean age about 5 years. Symptoms are attributed to chronic pathogen-free inflammation of both gray and white matter. There is a progressive unihemispheric atrophy (Rasmussen 1978). In 50% of patients, the onset of Rasmussen encephalitis is preceded by an inflammatory episode such as an U.R.I.
A symposium on psychotherapy in the age of managed care.

This article is based upon a symposium presented at Vanderbilt University Medical Center on the Department of Psychiatry's 50th anniversary (September 20, 1997). The panel of psychotherapy scholar-clinicians discusses issues including: whether or not managed care and psychotherapy are compatible; the relevance of the Consumer Reports' psychotherapy study to MCOs' emphasis on brief therapy; how MCOs impact upon the therapist-patient relationship; the effects of MCOs on the psychotherapist's personal and professional identity; and training psychotherapists in the era of managed care. The paper is dedicated to Pietro Castelnuovo-Tedesco, M.D., Vanderbilt's Blakemore Professor of Psychiatry, who died on January 24, 1998.
Intracellular gold nanoclusters boost energy conversion.

Intracellular gold nanoclusters act as photosensitizers, enabling non-photosynthetic bacteria to produce acetic acid from carbon dioxide in a more efficient and durable fashion.
A changing paradigm of transcriptional memory propagation through mitosis.

The highly reproducible inheritance of chromosomes during mitosis in mammalian cells involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range intrachromosomal interactions, loss of enhancer–promoter proximity, displacement of many transcription regulators from the chromatin and a marked decrease in RNA synthesis. Despite these dramatic changes in the mother cell, daughter cells are able to faithfully re-establish the parental chromatin and gene expression features characteristic of the cell type. Pioneering studies of mitotic chromatin signatures showed that despite global repression of transcription, the Hsp70 gene promoter retains an open chromatin conformation, which was proposed to allow the reactivation of the Hsp70 gene upon completion of mitosis — a phenomenon termed mitotic bookmarking. It was later shown that various cell-type-specific transcription factors, such as GATA-binding factor 1 (GATA1) in erythroblasts and forkhead box protein A1 (FOXA1) in hepatocytes, remain bound at a subset of their interphase binding sites in mitosis. Such bookmarking transcription factors remain on chromosomes in mitosis and have been shown to enable a subset of genes to be reactivated in a timely fashion upon mitotic exit. In addition, sensitive new methods to measure transcription revealed that mitotic cells retain residual transcription at a large number of genes. Furthermore, genes recover their interphase level of transcription in distinct waves. Thus, gene expression is precisely regulated as cells pass through mitosis to ensure faithful propagation of cell identity and function through cellular generations.
Revenge is sweet

The first half of this paper defends the claim revenge is a personal good. That is, it is the sort of thing, the pursuit of which, for oneself, always provides a reason for action. This makes trouble for the dominant philosophical view of the relation between morality and practical reason: a view held by theorists we can call ‘Angels’. Angels hold that moral requirements are also rational requirements. Devils, on the other hand, hold that immoral behavior is at least sometimes rationally required, so that one would have to act against reason to do what is right. The position in the largely undefended space between the Angels and the Devils is occupied by those we can call ‘Humans’. Humans acknowledge that immoral behavior is sometimes rationally permissible, but they also hold that it is never rationally required. The second half of the paper explains how one can endorse the view that revenge is a good without becoming a Devil. It also argues that the goodness of revenge supports the existence of a theoretically interesting kind of reason: a purely justifying reason.
The Effect of Manuka Honey on dHL-60 Cytokine, Chemokine, and Matrix-Degrading Enzyme Release under Inflammatory Conditions

A large body of in vivo and in vitro evidence indicates that Manuka honey resolves inflammation and promotes healing when applied topically to a wound. In this study, the effect of two different concentrations (0.5% and 3% v/v) of Manuka honey on the release of cytokines, chemokines, and matrix-degrading enzymes from neutrophils was examined using a differentiated HL-60 cell line model in the presence of inflammatory stimuli. The results indicate that 0.5% honey decreased TNF-α, IL-1β, MIP-1α, MIP-1β, IL-12 p70, MMP-9, MMP-1, FGF-13, IL-1ra, and IL-4 release, but increased MIP-3α, Proteinase 3, VEGF, and IL-8 levels. In contrast, 3% honey reduced the release of all analytes except TNF-α, whose release was increased. Together, these results demonstrate a dose-dependent ability of Manuka honey to modify the release of cytokines, chemokines, and matrix-degrading enzymes that promote or inhibit inflammation and/or healing within a wound. The findings of this study provide further guidance for the future use of Manuka honey in wounds or tissue engineering templates. Future in vivo investigation is warranted to validate the in vitro results and translate these results to physiologically relevant environments
Escaping Local Risk by Entering Indentureship: Evidence from Nineteenth-Century Indian Migration

Of the millions of Indians who migrated internationally in the long nineteenth century, over one million went as indentured servants in a massive South-South migration. I test how price volatility in origin markets in India affected out-migration under indentureship contracts from 1873–1916 to four major destinations around the world. Using new, unique district-level flows calculated from roughly 250,000 individual records, I show that indentureship take-up is consistent with migrating to escape local price volatility.
Multiple Asteroid Retrieval Mission from Lunar Orbital Platform-Gateway Using Reusable Spacecrafts

This paper describes the results of a study to find possible Near Earth Asteroids (NEA) capable of being captured using upcoming rocketry for the purposes of space-based mining, combining reusable rockets such as SpaceX's Big Falcon Rocket (i.e. BFR) and refueling capabilities. This work introduces a relatively low-cost option with higher Delta V, $\triangle V$ , compared to non-reusable rockets, and an opportunity for NASA's Lunar Orbital Platform-Gateway (LOP-G) for synergy with services, science, and technologies. In an effort to maximize the number of viable missions, the study focused on choosing a refueling orbit near LOP-G; thus, the Earth-Moon Lagrange points L1 and L2 were selected as possible choices for this paper. The resulting simulations of a Cislunar infrastructure orbiting in Lagrange points highlight differences in orbital options. Indeed, the optimal option is balanced between a Near Rectilinear Halo Orbit (NRHO) in L1 and a NRHO in L2. The decision for optimal positioning of any Gateway Station is dependent on the type of mission allocated to the Cislunar station. However, both options seem promising, not only for asteroid extraction and mining but also for crewed and cargo missions. In a worst case scenario, an operation of 3 decades starting in 2030 retrieving 33 asteroids, or 1.1 per year, comprising up to 2,581 tons in minerals. The work culminated in developing a data mining online tool that searches the entire Near Earth Asteroids (NEA) close approach database from JPL and the small body database from NASA. Using a fleet of 10 BFRs over 30 years may provide a higher long-term success for a business case than any other investment on Earth.
Paleoarchean Spherule Layers

The Archean marks the earliest time in Earth history for which there is a decipherable record of surface events. As noted in Chap. 7, the end of the Archean Eon is formally defined chronologically as 2,500 Ma. The International Union of Geological Sciences (IUGS) provisionally recommended dividing the Archean into four Eras named the Neoarchean, Mesoarchean, Paleoarchean, and Eoarchean (Robb et al. 2004). They also suggested placing the Mesoarchean-Neoarchean boundary at 2,800 Ma, the Paleoarchean-Mesoarchean boundary at 3,200 Ma, and the Eoarchean-Paleoarchean boundary at 3,600 Ma. The time period from the start of Earth history to the beginning of the Archean is widely referred to as the Hadean, but there is no universal agreement on where to place the Hadean-Eoarchean boundary. Robb et al. (2004) say the age of the Hadean-Eoarchean boundary is ‘‘undetermined,’’ whereas Van Kranendonk et al. (2008) gave an age of ~4,000 Ma for the boundary but other values (e.g., 4,030 Ma) are under consideration. Cawood et al. (2006) put the boundary at 3.8 Ga, whereas Tanaka and Hartmann (2008) avoid the term Hadean altogether and extend the Eoarchean from 3,600 Ma back to the start of Earth history. In terms of the IUGS recommended subdivision, the spherule layers described in this chapter are all Paleoarchean in age. More significantly, they are ~600 million years or more older than the Neoarchean layers described in Chap. 8, and no distal ejecta or spherule layers of intermediate ages have been reported.
Teachers’ awareness in identifying microaggressive behaviors within the K-12 classroom

In the field of education, teachers are sentries for maintaining proper decorum, upholding school policies, and maintaining a social justice classroom, free of adversarial behaviors. While the premise of proper social and academic student engagement is expected, teachers are not always aware of or able to respond to inappropriate social interactions. This qualitative study using a narrative inquiry approach investigates and portrays the levels of awareness and decision-making processes teachers possess when addressing microaggression and microaggressive behaviors. Five public school teachers from varying grade levels in a culturally diverse school district participated in semi-structured, in-depth interviews for this study. Emergent themes included: (a) awareness and recognition of microaggression as related to bullying, (b) microaggression as denigrating behavior directed toward others, and (c) microaggression with the school discipline framework. Findings suggest that teachers often lack awareness of microaggression as a concept distinct from bullying. But when the distinction is evident, teachers understand how microaggression can be a precursor to bullying which, if proactively addressed within the school discipline framework, may result in preventing bullying incidents before they start. Teachers were interested in receiving targeted professional development and adjusting school discipline policy to consider microaggression a unique concept. Guidance is offered to support educators, schools, and districts as clear guidelines and policies are established pertaining to identifying and addressing microaggression within the school community, thereby ensuring social and behavioral awareness.
State space discovery in spatial representation circuits with persistent cohomology

Persistent cohomology is a powerful technique for discovering topological structure in data. Strategies for its use in neuroscience are still undergoing development. We explore the application of persistent cohomology to the brain9s spatial representation system. We simulate populations of grid cells, head direction cells, and conjunctive cells, each of which span low-dimensional topological structures embedded in high- dimensional neural activity space. We evaluate the ability for persistent cohomology to discover these structures and demonstrate its robustness to various forms of noise. We identify regimes under which mixtures of populations form product topologies can be detected. Our results suggest guidelines for applying persistent cohomology, as well as persistent homology, to experimental neural recordings.
Clinician perspectives on inpatient cystatin C utilization: A qualitative case study at Mayo Clinic.

Introduction Serum creatinine (SCr) testing has been the mainstay of kidney function assessment for decades despite known limitations. Cystatin C (CysC) is an alternative biomarker that is generally less affected than SCr by pertinent non-renal factors in hospitalized patients, such as muscle mass. Despite its potential advantages, the adoption of CysC for inpatient care is not widespread. At one hospital with CysC testing, we demonstrated a significant rise in non-protocolized use over the last decade. This study uses qualitative methods to provide the first report of how clinicians understand, approach, and apply CysC testing in inpatient care. Methods Fifteen clinicians from various disciplines were interviewed about their experience with inpatient CysC testing. The semi-structured interviews were audio-recorded, transcribed verbatim, and analyzed thematically using a phenomenological approach. Results Knowledge and confidence with CysC varied greatly. Clinicians reported first learning about the test from colleagues on consulting services or multidisciplinary teams. The majority believed CysC to provide a more accurate measure of kidney function than SCr. Common scenarios for CysC ordering included medication dosing, evaluation of acute kidney injury, and a thorough evaluation of kidney function in patients with risk factors for an altered SCr. Facilitators for ordering CysC included the availability of rapid results turnaround and the automated calculation of glomerular filtration rate based on the biomarker. Barriers to use included a lack of education about CysC, and the absence of an institutional protocol for use. Discussion Clinicians at our site decided independent of institutional guidance whether and when CysC added value to patient care. While the majority of study participants indicated advantages to rapid turnaround CysC testing, its use depended not just on the features of the specific case but on clinician familiarity and personal preference. Findings from this research can guide the implementation and expansion of CysC testing.
Semi Automotive Vehicle Using Raspberry

Voice controlled robotic framework is exceptionally helpful in self driving vehicles and also territories where there is high hazard for people to enter. Voice controlled robotic framework is controlled through voice orders got by means of android gadget. Using the speech as the interface for processes became more important with the improvements of artificial intelligence. Robot direction controlling along with speed control is main motto of this concept. Three speeds are generated using PWM signals based on user speech command. The proposed system allows user to view live video from robot position through General WIFI communication. Raspberry stops its movement if any obstacle comes in its direction. Battery voltage measurement is also done by this amazing robot to alert user.
Postpartum pathologic changes associated with a palpable uterine lumen in dairy cattle

15 holstein cows with a palpable uterine lumen (PUL) at first postpartum palpation were identified and each cow was matched with a normal cow for parity and stage of lactation. Blood was collected from each cow and the uterus cultured, flushed with lactated Ringer's solution and biopsied. Analysis of blood samples indicated that all cows were healthy. Bacteria were isolated form 14 of 15 PUL cows and 13 of 15 normal cows. Uterine flush analysis showed evidence of an inflammatory response in 5 PUL cows and 1 normal cow. Mean scores from microscopical examination of the biopsy specimens were greater in PUL cows, indicating increased pathologic changes in this group.
Maximizing (Electro)catalytic CO2 Reduction with a Ferredoxin-Based Reduction Potential Gradient

Tuning the electron-transfer (ET) steps in redox reactions has proven to be an effective strategy to modulate enzyme catalysis. Here, we use 2-oxoacid:ferredoxin oxidoreductase (OFOR) as a model sy...
Adverse Effects of Antiresorptive Therapy

Adverse effects of antiresorptive therapy contribute to high rates of non-adherence to osteoporosis treatments. Gastrointestinal side effects are the most common cause of oral bisphosphonate discontinuation, and acute phase reactions are the most common adverse effect of IV bisphosphonate therapy. Popular press articles and social media often mischaracterize the prevalence of extremely rare bisphosphonate side effects like osteonecrosis of the jaw and atypical femur fractures. Learning about risk factors for these side effects can help prevent them by choosing appropriate candidates for therapy. Understanding of these side effects can help promote prompt and effective treatment. Knowing about the frequently overstated prevalence of these side effects can help guide evidence-based risk benefit discussions when deciding on treatment options to prevent the morbidity and mortality of devastating osteoporotic fractures while minimizing the risks of therapy.
SCAMP: Peer-to-Peer Lightweight Membership Service for Large-Scale Group Communication

Gossip-based protocols have received considerable attention for broadcast applications due to their attractive scalability and reliability properties. The reliability of probabilistic gossip schemes studied so far depends on each user having knowledge of the global membership and choosing gossip targets uniformly at random. The requirement of global knowledge is undesirable in large-scale distributed systems.In this paper, we present a novel peer-to-peer membership service which operates in a completely decentralized manner in that nobody has global knowledge of membership. However, membership information is replicated robustly enough to support gossip with high reliability. Our scheme is completely self-organizing in the sense that the size of local views naturally converges to the 'right' value for gossip to succeed. This 'right' value is a function of system size, but is achieved without any node having to know the system size. We present the design, theoretical analysis and preliminary evaluation of SCAMP. Simulations show that its performance is comparable to that of previous schemes which use global knowledge of membership at each node.
The application of MAGIC internal combustion engine model: turbulent combustion results

Modele de calcul des processus thermophysiques dans un moteur a combustion interne (MAGIC: modelling algorithm for generic internal combustion engines). Resultats obtenus pour une combustion turbulente