cssi/SciSciGPT-SciSciNet huggingface dataset:
Study of Ordering in High‐Quartz Solid Solutions by Substitutions Affecting Superlattice Reflections

Ordering of the interstitial and network atoms in stuffed high-quartz solid-solution (ss) phases was studied by correlating suitable substitutions in the structure with the resultant changes in the superlattice reflections arising from these phases. In an MgO·Al2O3·3SiO2 high-quartz ss, the special ordering of the interstitial Mg atoms, which produces satellite reflections around superlattice positions, was disturbed by replacement of ∼20 mol% of the MgO by Li2O or ZnO. The interstitial atoms were further disordered by larger substitutions. The streaked superlattice reflections arising from an Li2O·Al2O3·2SiO2 high-quartz ss disappeared on replacement of ∼40 mol% of the Li2O by MgO. This result implies that the interstitial Li atoms are ordered and were disordered by the substitution. The superlattice reflections were much intensified when ∼25 mol% of the SiO2 was replaced by GeO2. However, these reflections were intensified to a lesser degree when presumably both SiO2 and Al2O3 were partially replaced by GeO2 and Ga2O3, respectively. These observations strongly suggest an ordering of the network Si and Al atoms, which, together with the ordering of the interstitial Li atoms, contributed to the original streaked superlattice reflections.
Performance Calculations for 1000 MWp Magnetohydrodynamic/Steam Power Plants

The effects of MHD generator operating conditions and constraints on the performance of MHD/steam power plants are investigated. Power plants using high-temperature combustion air preheat (1644 K) and plants using intermediate-temperature preheat (866 K) with oxygen enrichment are considered. Variations of these two types of power plants are compared on the basis of fixed total electrical output (1000 MW). Results are presented to show the effects of generator length and level of oxygen enrichment on the plant thermodynamic efficiency and on the required generator mass flow rate. Factors affecting the optimum levels of oxygen enrichment are analyzed. It is shown that oxygen enrichment can reduce the magnet stored energy requirement.
MONO- AND POLYCULTURE OF Penaeus vannamei AND P. stylirostris IN PONDS

Polyculture of fish has been shown to be an effective means of increasing production beyond that achieved in monoculture, but little research has been conducted to evaluate the effect of polyculture on production of shrimp species. This research was designed to investigate performance of Penaeus vannamei (v) and P. stylirostris (s) in monoculture (treatments 100v and 100s) as well as in polyculture at various species ratios (75v:25s, 50v:50s, and 25v:75s) at a constant density of 1.8 × 105 /ha. Shrimp were stocked into fifteen 0.1-ha ponds at the Texas AM however, no significant difference in mean value was detected between the 100v and 75v:25s treatments. As a secondary objective of this study, performance of shrimp (25v: 75s treatment) in a single-phase pond system was compared to that in a three-phase (nursery, intermediate, and grow-out) system. Survival, growth, production, and value were found to be similar between systems.
Seismic characterization of delta front sand bodies in Lower Magdalena Valley basin and their potentiality as reservoirs in Cienaga de Oro Formation, Colombia.

Introduction The Lower Magdalena Basin is located in the northwest of Colombia where oblique subduction along the Romeral fault system has produced transpressional and transtensional deformation since late Cretaceous to present day. The Lower Magdalena Basin is limited to the northeast by the Bucaramanga Santa Marta fault system; to the south by the Central Cordillera and to the west by the Romeral fault system. This basin is subdivided by three structural elements that have controlled sedimentation since Eocene to late Miocene. These structural elements are: The Plato sub-basin to the north, the Cicuco Arch in the central part, and the San Jorge sub-basin to the south. Within the sequence, Cienaga de Oro Formation is subdivided in Upper and Lower, where the Upper corresponds to transitional delta facies and the lower to delta front sandstone deposits, the objective of this study. Delta front deposits are from transitional environment deposits and are formed by high volumes of sediments that have been transported from their original location due to hyperpycnal flow. Although the bulk of the material in delta front deposits are sand and silt blocks that could represent potential reservoir, having good reservoir quality and being surrounded by shale material of distal delta facies. The objective of this study is to highlight these sandstone blocks within the Lower Cienaga de Oro formation using seismic attributes and estimate the amount of hydrocarbon present in one of those blocks.
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

IL-2 plays a critical role in the maintenance of CD4+CD25+ FOXP3+ regulatory T cells (Tregs) in vivo. We examined the effects of IL-2 signaling in human Tregs. In vitro, IL-2 selectively up-regulated the expression of FOXP3 in purified CD4+CD25+ T cells but not in CD4+CD25- cells. This regulation involved the binding of STAT3 and STAT5 proteins to a highly conserved STAT-binding site located in the first intron of the FOXP3 gene. We also examined the effects of low-dose IL-2 treatment in 12 patients with metastatic cancer and 9 patients with chronic myelogenous leukemia after allogeneic hematopoietic stem cell transplantation. Overall, IL-2 treatment resulted in a 1.9 median fold increase in the frequency of CD4+CD25+ cells in peripheral blood as well as a 9.7 median fold increase in FOXP3 expression in CD3+ T cells. CD56+CD3- natural killer (NK) cells also expanded during IL-2 therapy but did not express FOXP3. In vitro treatment of NK cells with 5-aza-2′-deoxycytidine restored the IL-2 signaling pathway leading to FOXP3 expression, suggesting that this gene was constitutively repressed by DNA methylation in these cells. Our findings support the clinical evaluation of low-dose IL-2 to selectively modulate CD4+CD25+ Tregs and increase expression of FOXP3 in vivo.
Radiolabeling of commercial 99mTc Sestamibi kits using an electric heating device

2419 Objectives Within the past several years, generic Tc-99m Sestamibi Kits have been introduced. The aim of the study was to establish effective parameters for radiolabeling generic Tc-99m Sestamibi kits from various manufacturers under clinical radiopharmaceutical settings, utilizing an electric heating device. Methods Sestamibi kits from two manufacturers, DraxImage (New York, NY) and Pharmalucence (Bedford, MA) were utilized. Initial evaluation of internal vial solution temperatures was performed by injecting 5.0 ml normal saline into four empty kit vials, inserting a thermometer, heating two vials at instrument calibrated setting of 100°C and 120°C, respectively. Vial temperature was measured every 2 minutes for a total of 16 minutes. Radiolabeling of Sestamibi kits was performed with two Drax and two Pharmalucence vials by adding Tc-99m pertechnetate (498 - 509 mCi) to each vial followed by heating for 15 minutes on an electric heating device. Two vials were heated at 100°C and 120°C, respectively. Following radiolabeling, radiochemical purity was assessed with miniaturized chromatography consisting of Whatman 31 ET and ethyl acetate. Three replicate samples were evaluated for each radiochemical purity assessment and the data was statistically summarized. Results Radiochemical purity greater than 90% was achieved for Tc-99m Sestamibi preparations from Pharmalucence at both temperatures. Radiochemical purity of Tc-99m Sestamibi from DraxImage was below 90% at a lower temperature of 100° C, but exceeded 90 % when increased to 120° C. Consistent internal vial temperatures greater than 100° C resulted acceptable radiochemical purity results. Conclusions Effective radiolabeling parameters for generic Tc-99m Sestamibi preparations using an electric heating plate were established. Lower temperatures were necessary to radiolabel Pharmalucence sestamibi kits whereas higher temperatures were needed to effectively radiolabel DraxImage sestamibi kits
Features of laminar and somatotopic organization of lumbar spinal cord units receiving cutaneous inputs from hindlimb receptive fields

Single-unit recordings from 312 units of lamina I-VII of the lumbar spinal cord of unanesthetized, decerebrate, T8 spinal cats were used to determine the somatotopic and laminar organization of spinal neurons responding to cutaneous stimulation of the hindlimb. Properties of cells confined to different Rexed laminae (I-VII) were shown to differ in several respects, including responses to variations in stimulus intensity, receptive-field areas, spontaneous frequencies, and central delays. Spinal cord neurons with similarly localized cutaneous receptive fields were found to be organized in sagittally oriented rectangular columns. These columns were 7 to at least 20 mm long (rostral-caudal axis), 0.5-1.0 mm wide, and could encompass laminae I-VII in depth. Touch, pressure, and pinch were effective excitatory inputs into each column subserving a given receptive-field location. A map of the somatotopic organization of units in the horizontal plane is presented, which in general confirms previous reports and in particular deals with the organization of units with receptive fields on the plantar cushion and individual toes.
The Biology and Ecology of Granary Mites of the Pacific Northwest I. Ecological Considerations

The role of phytophagus, predaceous, parasitic and saprophagous mites found in stored grain in Oregon, Washington and Idaho is discussed. The ecological interrelationships of granary mites with other members of the granary community also are reviewed. A checklist of granary mites found in the Pacific Northwest is included, with species arranged as to food preferences.
On Archaic Words in Idiom of Southern Hunan Province

This paper analyzes through examples the archaic words in idiom of southern Hunan province, including the words from archaic dialect and archaic common language, traces their origins and illustrates their distribution in idiom of southern Hunan provice.
Sample Design of Equivalence Division Test

Equivalence class division is one of the typical test methods of black box.To divide all the data in the program to be tested into several parts and take from each part a few representative data as test sample can effectively reduce test times,improve software test effeciency and shorten software development cycle.
Influence of model resolution on geometric simulations of antibody aggregation

It is estimated that allergies afflict up to 40% of the world's population. A primary mediator for allergies is the aggregation of antigens and IgE antibodies bound to cell-surface receptors, FceRI. Antibody/antigen aggregate formation causes stimulation of mast cells and basophils, initiating cellular degranulation and releasing immune mediators which produce an allergic or anaphylactic response. Understanding the shape and structure of these aggregates can provide critical insights into the allergic response. We have previously developed methods to geometrically model, simulate and analyze antibody aggregation inspired by rigid body robotic motion simulations. Our technique handles the large size and number of molecules involved in aggregation, providing an advantage over traditional simulations such as molecular dynamics (MD) and coarse-grained energetic models. In this paper, we study the impact of model resolution on simulations of geometric structures using both our previously developed Monte Carlo simulation and a novel application of rule-based modeling. These methods complement each other, the former providing explicit geometric detail and the latter providing a generic representation where multiple resolutions can be captured. Our exploration is focused on two antigens, a man-made antigen with three binding sites, DF3, and a common shrimp allergen (antigen), Pen a 1. We find that impact of resolution is minimal for DF3, a small globular antigen, but has a larger impact on Pen a 1, a rod-shaped molecule. The volume reduction caused by the loss in resolution allows more binding site accessibility, which can be quantified using a rule-based model with implicit geometric input. Clustering analysis of our simulation shows good correlation when compared with available experimental results. Moreover, collisions in all-atom reconstructions are negligible, at around 0.2% at 90% reduction.
Lactic Acidosis: A Rare Oncological Emergency in Solid Tumors at Presentation

Lactic acidosis is a potentially life-threatening complication characterized by accumulation of blood lactate resulting in low arterial pH. The majority of lactic acidosis in malignancies are reported in association with hematologic malignancies. It may result from an imbalance between lactate production and hepatic lactate utilization, but the exact pathophysiology is far more complex than what we can fathom from current micromolecular studies. We report a case of a 71-year-old male with metastatic lung cancer presenting with fatal lactic acidosis in the absence of liver involvement. Review of the literature reveals only 27 reported cases of solid tumors presenting with lactic acidosis, of which nearly all of them had extensive liver metastasis. Patients were treated with aggressive fluid resuscitation, bicarbonate administration and hemodialysis, but the only effective treatment modality was early aggressive chemotherapy initiation.
Influence of masker bandwidth on binaural masking level differences.

Masking level differences (MLDs) were investigated using masking noise with 160 Hz (amplitude-modulated noise) and 600 Hz (filtered-random noise) bandwidth. One hundred normally hearing subjects received the MLD test under both types of noise. Significant differences between noise types were observed in both N0Sπ and NπS0 conditions; MLDs were larger in amplitude-modulated noise. Consideration of these differences would indicate that older MLD norms based solely on filtered-random noise are invalid for amplitude-modulated noise especially where bandwidth differences in the noise exist. Were the norms for 600-Hz-wide filtered-random noise to be applied to results of MLD testing performed using 160-Hz-wide amplitude-modulated noise, patients with lesions in the central auditory pathway might exhibit normal or borderline normal results. Clinical MLD norms established on one type of noise should not be used to interpret MLD results obtained using a different type of noise.
Residual Empirical Processes and Weighted Sums for Time‐Varying Processes with Applications to Testing for Homoscedasticity

In the context of heteroscedastic time-varying autoregressive (AR)-process we study the estimation of the error/innovation distributions. Our study reveals that the non-parametric estimation of the AR parameter functions has a negligible asymptotic effect on the estimation of the empirical distribution of the residuals even though the AR parameter functions are estimated non-parametrically. The derivation of these results involves the study of both function-indexed sequential residual empirical processes and weighted sum processes. Exponential inequalities and weak convergence results are derived. As an application of our results we discuss testing for the constancy of the variance function, which in special cases corresponds to testing for stationarity.
From Judgment to Illumination

Documentaries tend to do poorly at the box office, where audiences prefer diverting fiction to stark reality. This is unfortunate, because some of the most powerful and important films about the Holocaust are “nonfiction” but not “nondramatic.” Consequently, television has played a significant role in bringing at least two of the following to American audiences: Kitty: Return to Auschwitz, The Sorrow and the Pity (both telecast on PBS), and The Memory of Justice . All three are compelling personal documents – moving pictures that achieve their greatness through uniquely cinematic means. Brave and often abrasive, they demonstrate that the facts of the Holocaust are richer than the fictions an artist could invent. Particularly in the films of Marcel Ophuls, the montage is the message – namely the juxtaposition of multiple viewpoints which, together, shed light on human response and responsibility. When Kitty: Return to Auschwitz (1980) was aired on American television, on February 4, 1981, the question raised after Holocaust – how much truth can be found in a fictional reconstruction of the Nazi era? – was replaced by the acknowledgment of how much drama could inhere in documentary. This ninety-minute film directed by Peter Morley for Yorkshire Television in Great Britain is real “docudrama” – the simple presentation of one survivor's recollection that yields a profoundly moving and often shattering story. Kitty Felix Hart, a fifty-one-year-old radiologist in Birmingham, returned in 1978 to Auschwitz – where she and her mother had been prisoners for two years – with her son David, a Canadian doctor.
Essential Oil Variability and Biological Activities of Tetraclinis articulata (Vahl) Mast. Wood According to the Extraction Time.

In the present work, the hydrodistillation (HD) and microwave-assisted hydrodistillation (MAHD) kinetics of essential oil extracted from Tetraclinis articulata (Vahl) Masters wood was conducted, in order to assess the impact of extraction time and technique on chemical composition and biological activities. GC and GC–MS analyses showed significant differences between the extracted essential oils, where each family class or component presents a specific kinetic according to extraction time, technique and especially for the major components: camphene, linalool, cedrol, carvacrol and α-acorenol. Furthermore, our findings showed a high variability for both antioxidant and anti-inflammatory activities, where each activity has a specific effect according to extraction time and technique. The highlighted variability reflects the high impact of extraction time and technique on chemical composition and biological activities, which led to conclude that we should select essential oils to be investigated carefully depending on extraction time and technique, in order to isolate the bioactive components or to have the best quality of essential oil in terms of biological activities and preventive effects in food. This article is protected by copyright. All rights reserved.
Judicial independence and state-business relations: the case of Taiwan’s ordinary courts

ABSTRACTThe question of how ordinary courts in new and emerging democracies may gain judicial independence remains an understudied subject compared to its constitutional court counterpart. Through a case study of Taiwan, this article adopts and expands upon the concept of power diffusion from the extant literature, arguing that the growing power of Taiwan’s private corporate sector led the dominant political party Kuomintang (KMT) to grant independence to the ordinary courts as a means to check against this threat, because the excessive rent-seeking and corruption brought about by these empowered corporations were threatening the nation’s successful economic model and its rule of law. Also, due to the corporate sector’s growing influence on the ruling party itself, the KMT leadership had to devise strategies that can credibly commit to ordinary court independence, which would otherwise be reversed thereafter. This unique implication guides a qualitative empirical analysis that reinterprets the historical ...
Joint Decode-and-Forward and jamming for wireless physical layer security with destination assistance

A distributed wireless network with one source, one destination, one eavesdropper and multiple Decode-and-Forward (DF) relays is considered. A two-slot cooperative relaying scheme is proposed, in which relays help the source transmit to the destination while keeping the message as secret as possible from the eavesdropper. In the first slot, the source transmits a weighted combination of the information bearing signal and a noise signal. At the same time, the destination cooperates with the source in transmitting a noise signal with the purpose of confounding the eavesdropper. In the second slot, the ‘best’ relay cooperates with the source to send a jamming signal along the null space of the destination channel. Optimal relay selection and also optimal power allocation among the first/second slot data signal and jamming noise is proposed. With the proposed transmission scheme, the system secrecy rate is shown to outperform the methods in literature and always benefits from increasing total power and larger number of relays.
Experimental Validation of Comprehensive Steady-State Analytical Model of Bidirectional WPT System in EVs Applications

A flexible, automatic, reliable, and safe charging and discharging system for electric vehicles (EVs) and hybrid EVs is crucial in vehicle-to-grid (V2G) operation. The bidirectional inductive wireless power transfer system (BIWPTS) is an ideal solution in this situation. With authentic power-flow models for the BIWPTS in hand, designers and operators can predict, optimize, and analyze the interaction performance between the EV and the grid. Thus, this paper presents a harmonics-based theoretical power-flow model for BIWPTS for charging and discharging EVs in V2G applications. The proposed model provides accurate estimation for the active and reactive power flow during V2G and grid-to-vehicle modes. Moreover, the impact of the circuit losses and harmonics, due to the high-frequency power inverters, on the power-flow performance is investigated. This effect is stated mathematically by four novel power-flow criteria formulas. New conditions for achieving maximum active and reactive power, and unity and zero power-factor system operation, are also developed. The sensitivity of the circuit performance to the variation of its parameters has been studied. For validation purposes, a computer-based model and experimental platform of BIWPTS for EV applications are developed and tested. The comparison between the theoretical, simulation, and experimental results verified the proposed models and analysis.
The Role of Simulations in Neuropharmacology

Computational models and simulations have evolved dramatically in the past decades, providing useful insights on neurological systems, their functions and dynamics. They successfully deepened our knowledge on systems ranging from biomolecular to neuronal network scale. In spite of these successes, Modeling and Simulation still represent a marginal contribution to the field of neuropharmacology. What may be the reasons behind this? These pages succinctly describe the current state of neuropharmacology, and provide arguments in favor of amplifying the role of Modeling and Simulation on the various phases of the drug discovery and development process for the nervous system. We provide examples illustrating how Modeling and Simulation can guide neuropharmacology. We then present a methodology for building multiscale models by reducing the computational complexity while maintaining predictability levels using computationally efficient input-output modeling. Finally, we deliver arguments in support of generalizing Modeling and Simulation in neuropharmacology to make it a cornerstone of the drug discovery and development process.
Does Hip Arthroscopy Have a Role in the Treatment of Developmental Hip Dysplasia

Abstract Background Indications for hip arthroscopy in mildly dysplastic patients with a symptomatic hip remain controversial. Methods This article provides a concise review of the available literature evaluating the role of hip arthroscopy in treating symptomatic dysplasia. Potential indications for hip arthroscopy in isolation are reviewed. Emerging evidence on the role of hip arthroscopy based on patient-specific pathomorphology is highlighted. Results Hip arthroscopy in isolation may be helpful for select dysplastic patients with dynamic impingement or microinstability. Isolated arthroscopic treatment of intra-articular pathology resulting from static overload is unlikely to be successful in the long term and may be detrimental. Conclusion Arthroscopic procedures for individuals with mild dysplasia in the absence of frank instability may be effective; however, great caution should be exercised when approaching dysplastic patients with symptomatic hips.
Teacher learning of technology-enhanced formative assessment

This study examined the integration of technology enhanced formative assessment (FA) into teachers’ practice. Participants were high school physics teachers interested in improving their use of a classroom response system (CRS) to promote FA. Data were collected using interviews, direct classroom observations, and collaborative discussions. The physics teachers engaged in collaborative action research (AR) to learn how to use FA and CRS to promote student and teacher learning. Data were analyzed using open coding, cross-case analysis, and content analysis. Results from data analysis allowed researchers to construct a model for knowledge skills necessary for the integration of technology enhanced FA into teachers’ practice. The model is as a set of four technologies: hardware and software; methods for constructing FA items; pedagogical methods; and curriculum integration. The model is grounded in the idea that teachers must develop these respective technologies as they interact with the CRS (i.e., hardware and software, item construction) and their existing practice (i.e., pedagogical methods, curriculum). Implications are that for teachers to make FA an integral part of their practice using CRS, they must: 1) engage in the four technologies; 2) understand the nature of FA; and 3) collaborate with other interested teachers through AR.
Percent mammographic density prediction: development of a model in the nurses' health studies.

To develop a model to predict percent mammographic density (MD) using questionnaire data and mammograms from controls in the Nurses’ Health Studies’ nested breast cancer case–control studies. Further, we assessed the association between both measured and predicted percent MD and breast cancer risk. Using data from 2,955 controls, we assessed several variables as potential predictors. We randomly divided our dataset into a training dataset (two-thirds of the dataset) and a testing dataset (one-third of the dataset). We used stepwise linear regression to identify the subset of variables that were most predictive. Next, we examined the correlation between measured and predicted percent MD in the testing dataset and computed the r 2 in the total dataset. We used logistic regression to examine the association between measured and predicted percent MD and breast cancer risk. In the training dataset, several variables were selected for inclusion, including age, body mass index, and parity, among others. In the testing dataset, the Spearman correlation coefficient between predicted and measured percent MD was 0.61. As the prediction model performed well in the testing dataset, we developed the final model in the total dataset. The final prediction model explained 41% of the variability in percent MD. Both measured and predicted percent MD were similarly associated with breast cancer risk adjusting for age, menopausal status, and hormone use (OR per five unit increase = 1.09 for both). These results suggest that predicted percent MD may be useful for research studies in which mammograms are unavailable.
A concurrent approach for process design and multicomponent adsorption modeling with local isotherms

Abstract An iterative approach is proposed to predict the optimal concentration profiles in an adsorption process and to simultaneously obtain parameters for a multicomponent isotherm by selecting representative liquid compositions for experimental measurements. The proposed approach was demonstrated for xylene adsorption on zeolite 13X that has undergone a barium ion exchange. Breakthrough experiments were performed at liquid compositions predicted by the process model, which was refined in an iterative manner with the experimental data. Robustness of the isotherm parameters for model uncertainty and variations in the process design were also analyzed.
Synthesis and Optical Properties of Pentamethine Cyanine Dyes With Carboxylic Acid Moieties

Cyanine dyes possessing carboxylic acid groups have been used in many different fields of study. The acid groups can act as handles for bioconjugation or as metal chelators. Several pentamethine cyanine dyes with propionic acid handles were synthesized and their optical properties were studied to determine their usefulness as fluorescent probes. The optical properties studies performed include the absorbance and emission maxima values as well as the calculation of quantum yield and molecular brightness levels. Molecular models were also calculated to help analyze the dyes’ behavior and were compared with similar dyes with varying alkyl chain lengths replacing the acid moieties.
SEM imaging and Automated Defect Analysis at advanced technology nodes

As the scaling continues and industry moves to sub 1× nm nodes, Defect Review Scanning Electron Microscopy (DR-SEM) faces increasingly difficult challenges. The Defects of Interest (DOI) shrink as the features shrinks leading to imaging difficulty purely based on scale. The defect signal gets immersed in noise and the challenge of separating false from true is larger than ever. Also, more complex defect analysis is required for DOIs with 3D morphology and for previous layer DOI. A smart approach to DR-SEM must be adopted which allows for high quality imaging focused on yield improvements within a short cycle time. In this paper we demonstrate that reporting defects location in computer aided design (CAD) coordinates eliminates tool and user discrepancy in the inspection/review loop, facilitating robust DOI search at higher magnification and sensitivity. Further, smart implementation of defect analysis such as high landing energy see-through imaging, quantitative material analysis and tilt imaging on select DOI subsets allows for root-cause analysis and improved classification of defects which were previously misclassified or determined to be SNV (SEM non-visual).
Building nature’s market: the business and politics of natural foods

Laura J. Miller’s Building Nature’s Market: The Business and Politics of Natural Foods examines the development the natural food market in the United States. From its early days of marginalization ...
A distributed control architecture for a reconfigurable manufacturing plant

This work presents a novel approach for the implementation of industrial Cyber-Physical System (CPS) based on the integration of the IEC 61499 international standard for distributed industrial automation, as conceived in the DAEDALUS Horizon 2020 project. Among the different innovations introduced by the project, this work focuses on the establishment of internal cognitive functionalities: a Function Block for model-based optimal control is devised for the optimal orchestration of CPS. As a case study, the automation of a lab-scale industrial plant for End Of Life treatment of electronic circuit boards is developed with the proposed methodology. The plant orchestrator is a validated Hybrid Model Predictive Control solution. It is shown how it is possible to model complex systems, creating aggregated structures of CPSs, and to orchestrate them thanks to the distributed intelligence. The completion of the software development kit for a seamless development of optimal orchestration and logic control is the final objective of the ongoing project.
Serotonin and Mood: Neuroendocrine Aspects

The role of serotonin (5-HT) in the pathophysiology of mood disorders has been intensively investigated during the past 25 years (Meltzer and Lowy 1987). If 5- HT is involved in the etiology of affective disorders and the mechanism of action of thymoleptic drugs, it must have a significant role, direct or indirect, in the regulation of somatic processes that are disturbed in these mood disorders. In fact, 5-HT has been shown to have an important influence on mood itself, as well as on sleep, sexual activity, appetite, circadian rhythms, neuroendocrine function, anxiety, motor activity, and cognitive function, all of which are disturbed in affective disorders (Meltzer and Lowy 1987).
Parabolic Boundary-Value Problems

The use of upper and lower solutions as initial iterations, discussed in the previous chapter, leads to two monotone sequences each of which converges to a unique solution of an integral equation. This chapter shows that the limit of the monotone sequence is indeed the solution of the parabolic problem for each of the three basic boundary conditions. This regularity result is given in the framework of a more general parabolic boundary-value problem using the property of a fundamental solution. The same approach is extended to a class of integroparabolic equations of Volterra and Fredholm types. It is also extended to a parabolic boundary-value problem with time delay in the reaction function. Some qualitative properties of the solution such as positivity and boundedness are also included in the discussion.
Spatial and qualitative aspects of reasoning about motion

Reasoning about motion is an important part of common sense knowledge. The spatial and qualitative aspects of reasoning about motion through free space are studied through the construction of a program to perform such reasoning. An analog geometry representation serves as a diagram, and descriptions of both the actual motion of a ball and envisioning are used in answering simple questions.
Dynamic Group Key Distribution Using MDS Codes

Efficient key distribution is an important problem for secure group communications. In this paper, we present a new group key distribution scheme that supports dynamic multicast group membership changes. Instead of using encryption algorithms, the scheme employs MDS codes, a class of error control codes. The scheme achieves both forward and backward secrecy of sessions using freshly generated random session keys. The computation complexity of key distribution is significantly reduced using proper MDS codes with efficient encoding and decoding algorithms. The computation load is also more evenly distributed among the group key distribution controller (GC) and all the group members. Easily combined with any key-tree based schemes, this scheme provides much lower computation complexity, while maintaining low and balanced communication complexity and storage complexity for dynamic group key distribution.
Criteria for Selecting Practice Theories: Working with Alcoholic Women:

The authors analyze female alcoholics and consider the appropriateness of various theories for direct practice with this population. Criteria for the selection of theories to guide practice evolve ...
Delafloxacin (Baxdela) for Skin Infections.

Delafloxacin is a new fluoroquinolone antibiotic available in intravenous and oral formulations for the treatment of serious skin and skin structure infections in patients requiring initial intravenous therapy. It is effective for infections caused by MRSA or P. aeruginosa, in addition to other common causative pathogens, but has not been shown to be more effective than existing antibiotic regimens.
Flexural Basics of Analysis and Design

Analysis and design are two interrelated activities. Analysis is the determination of the effect of loads in a member based on the given properties and applied loads. Analysis is typically a deterministic process, that is, for a given set of conditions, a single result is calculated for each external load combination. Design is a creative process that establishes the parameters needed to conduct the analysis, including selection of appropriate member sizes, prestress, and connections. An engineer designs a structure, which can be a building, bridge, or other endeavor. The structure consists of members such as slabs, beams, columns, and foundations. The loads applied to the structure generate internal stresses in these members. Consequently, building codes require that the nominal strength of a member exceed the effects of externally generated loads at all sections.
The Adoption of Artificial Intelligence in Cancer Pathology and Imaging

Artificial intelligence (AI) is revolutionizing how the world operates, in manufacturing, in transportation, in advertising, and in criminal justice, how we communicate, and how we practice medicine. AI had undergone cyclical interests and disinterests over the past few decades, but recent surge of interest in AI owing to the emerging practical deep learning technologies that have caught the healthcare industry’s attention. Obtaining key understanding of AI is essential in incorporating such disruptive technologies into healthcare. The medical field is diverse and complex leading to a myriad of barriers in optimal integration in the clinical workflow, with some specialties reaping better success incorporating AI into their practices than other specialties. Medical imaging, notably radiology, is one success story due to the digital nature of their workload, allowing simple conversion for AI to complement their practices and to automate mundane tasks. On the other hand, pathology has limited success in combining pathological practice and AI due to a lack of supporting digital infrastructure and a complex imaging workflow. Other complications include the fear of the ambiguity, legal representation, responsibility and culpability, and significant capital expenditures necessary to keep the industry up-to-date, hindering the ability of AI to transform the healthcare landscape. Should these conundrums be addressed, AI could prove to be an incredibility powerful tool for improving the practice and productivity of oncologists and imaging specialists.
Role of p90 ribosomal S6 kinase in long-term synaptic facilitation and enhanced neuronal excitability

Multiple kinases converge on the transcription factor cAMP response element-binding protein (CREB) to enhance the expression of proteins essential for long-term synaptic plasticity and memory. The p90 ribosomal S6 kinase (RSK) is one of these kinases, although its role is poorly understood. The present study exploited the technical advantages of the Aplysia sensorimotor culture system to examine the role of RSK in long-term synaptic facilitation (LTF) and long-term enhancement of neuronal excitability (LTEE), two correlates of long-term memory (LTM). Inhibition of RSK expression or RSK activity both significantly reduced CREB1 phosphorylation, LTF, and LTEE, suggesting RSK is required for learning-related synaptic plasticity and enhancement in neuronal excitability. In addition, knock down of RSK by RNAi in Aplysia sensory neurons impairs LTF, suggesting that this may be a useful single-cell system to study aspects of defective synaptic plasticity in Coffin-Lowry Syndrome (CLS), a cognitive disorder that is caused by mutations in rsk2 and associated with deficits in learning and memory. We found that the impairments in LTF and LTEE can be rescued by a computationally designed spaced training protocol, which was previously demonstrated to augment normal LTF and LTM.
An Evaluation of the Functions of Challenging Behavior in Toddlers with and without Autism Spectrum Disorder

Despite the early onset of challenging behaviors, there is a lack of research investigating the function of challenging behavior in toddlers with autism spectrum disorder (ASD) and developmental disabilities (DDs). The current study evaluated group differences in the frequency and severity of five functions of challenging behavior (i.e., Attention, Escape, Nonsocial, Physical, Tangible). A total sample of 98 toddlers, aged 19–40 months, were classified into the ASD group or the atypical development group. No group differences were found in regard to the reported frequency of the function of behavior. Group differences in the severity of the function of behavior were found in the Attention function only. Significant differences across ASD symptom severity groups were also found in the Attention and Nonsocial functions. Clinical implications of the current findings are discussed.
Agustín Rayo, The Construction of Logical Space

Agustin Rayo, The Construction of Logical Space, Oxford University Press, Oxford, 2013, 220 pp.
Oncology Nursing Considerations when Developing Outpatient Staffing and Acuity Models.

Abstract Objectives Objectives include review of existing benchmarks and nurse-sensitive indicators relevant to the ambulatory care setting. Applying the data to existing ambulatory staffing models with consideration of multiple clinic settings that include medical oncology, infusion, and stem cell transplant clinics. And to describe key considerations needed to optimize oncology care efficiently with an acuity-based staffing model. Data Sources Published literature indexed in PubMed, CINAHL, textbooks. Conclusion In today's complex oncology environment, optimization and utilization of outpatient facilities is essential in providing high-quality care and improving satisfaction of patients as well as providers and staff. Implications for Nursing Practice Nurse leaders should utilize benchmarking data to ensure staffing levels are appropriate, given the size and scope of their facility. Staff nurses should be engaged to ensure that acuity tools are developed in accordance with their experiences and perceptions of patient care.
African Education: Consciencism or Neocolonialism

The essay analyzes educational relationship between Consciencism and neocolonialism in the post decolonized African countries. The concepts of education, Philosophical Consciencism, neocolonialism, and post-colonial traumatic syndrome are introduced and defined. A case is made that the current African education, as extensions of colonial curricula, is producing a neocolonial Philosophical Consciencism, intelligentsia, and collective personality that maintain the colonial characteristics in the form of neocolonialism in Africa. To produce Africentric Philosophical Consciencism, the curricula of African education must be Africanized especially the subjects in social sciences. It is the contents of education, as indicated by the curricula, that create acceptable boundaries of Consciencism, personality, thinking and problem-solving skills relevant to the dynamics of African existence and her transformations from colonialism to independence and emancipation by establishing a non-subservient cognitive zone over the social decision-choice space with Africa’s non-defective self-confidence for resisting being drawn into the spheres of beggar’s syndrome, neocolonialism, and imperial influence at all forms of the game of existence. The current African mind, through the neocolonial education, has been brought under control in the zone of neocolonial Philosophical Consciencism. In this way, the imperial problem of establishing neocolonial states for resource exploitation as well as preventing African independence, self-development, and creation of self-confidence has been solved by neocolonialists through the neocolonial education.
Domain Adaptation with Reconstruction for Disaster Tweet Classification

Identifying critical information in real time in the beginning of a disaster is a challenging but important task. This task has been recently addressed using domain adaptation approaches, which eliminate the need for target labeled data, and can thus accelerate the process of identifying useful information. We propose to investigate the effectiveness of the Domain Reconstruction Classification Network (DRCN) approach on disaster tweets. DRCN adapts information from target data by reconstructing it with an autoencoder. Experimental results using a sequence-to-sequence autoencodershow that the DRCN approach can improve the performance of both supervised and domain adaptation baseline models.
The 'Fairness Doctrine' lives on?: Theorizing about the Algorithmic News Curation of Google's Top Stories

When one searches for political candidates on Google, a panel composed of recent news stories, known as Top stories, is commonly shown at the top of the search results page. These stories are selected by an algorithm that chooses from hundreds of thousands of articles published by thousands of news publishers. In our previous work, we identified 56 news sources that contributed 2/3 of all Top stories for 30 political candidates running in the primaries of 2020 US Presidential Election. In this paper, we survey US voters to elicit their familiarity and trust with these 56 news outlets. We find that some of the most frequent outlets are not familiar to all voters (e.g. The Hill or Politico), or particularly trusted by voters of any political stripes (e.g. Washington Examiner or The Daily Beast). Why then, are such sources shown so frequently in Top stories? We theorize that Google is sampling news articles from sources with different political leanings to offer a balanced coverage. This is reminiscent of the so-called "fairness doctrine'' (1949-1987) policy in the United States that required broadcasters (radio or TV stations) to air contrasting views about controversial matters. Because there are fewer right-leaning publications than center or left-leaning ones, in order to maintain this "fair'' balance, hyper-partisan far-right news sources of low trust receive more visibility than some news sources that are more familiar to and trusted by the public.
Abstract MP03: Immunophenotyping A Heart Failure With Preserved Ejection Fraction (HFpEF) Mouse Model With Cellular Indexing Of Transcriptomes And Epitopes (CITE)-seq

Deoxycorticosterone acetate (DOCA)-salt is a common hypertension model in mice and has recently been used to study heart failure with preserved ejection fraction (HFpEF) in rats. Our goal was to va...
Immune Checkpoint Inhibitor-Related Pneumonitis in Lung Cancer: Real-World Incidence, Risk Factors, and Management Practices Across Six Health Care Centers in North Carolina.

Background Immune checkpoint inhibitors (ICIs) are standard treatments for advanced non-small cell lung cancer and have expanded use in small cell lung cancer. Although generally better tolerated than traditional chemotherapy, immune-related adverse events, such as immune checkpoint inhibitor-related pneumonitis (ICI-P), remain poorly understood toxicities that limit ICI treatment and can result in considerable morbidity. In this retrospective case-control study, we assessed a lung cancer cohort to identify ICI-P risk factors. Research Question What are the risk factors, clinical presentations, radiographic findings, and outcomes for ICI-P in a real-world lung cancer cohort? Do chronic pulmonary diseases confer increased risk for ICI-P? Study Design and Methods Medical records from lung cancer patients receiving nivolumab, pembrolizumab, or combination ipilimumab and nivolumab at six centers in North Carolina were reviewed (January 2004-July 2017). Patients with ICI-P and control participants were characterized, and logistic regression was used to assess for ICI-P risk factors. Results Three hundred fifteen lung cancer patients who predominantly received nivolumab (76.5%) or pembrolizumab (22%) were included. The incidence of ICI-P was 9.5%, with a median time to diagnosis of 52.5 days. Most patients with ICI-P had cases of high severity, and eight patients (27%) died with ongoing ICI-P treatment. Development of ICI-P was independently associated with the presence of baseline fibrosis on chest CT scan (adjusted OR [aOR], 6.61; 95% CI, 2.48-17.7), a composite measure of obstructive lung disease (aOR, 2.79; 95% CI, 1.07-7.29), and treatment with pembrolizumab (aOR, 2.57; 95% CI, 1.08-6.11). Interpretation In this cohort, ICI-P was more common and severe than previously reported and carried an unexpectedly high mortality rate. Risk for ICI-P was shown to be independently associated with several chronic pulmonary diseases, which may account for the higher incidence of ICI-P in patients with lung cancer.