cssi/SciSciGPT-SciSciNet huggingface dataset:
Short- term effect of heat wave on daily hospital admission in Guangzhou and Xingning

Objective To assess the impact of heat waves on the incidence of hospitalization of urban residents in Guangzhou and Xingning and identify the vulnerable population. Methods Data of daily meteorologic record and hospital admission during 2006 to 2011 were collected from two hospitals of the two cities. Distributed lag model was applied to estimate cumulative effects of heat waves on the incidence of hospitalization and meanwhile analyze the effect of heat waves on the age,sex,and disease category.Results During 2006- 2011,the temperature thresholds of heat waves in cities of Guangzhou and Xingning were 30. 8 and 30. 9 ℃,respectively. The total number of heat wave days,intensity of heat waves( mean daily temperatures during heat waves),and average number of days for continuous heat waves in Xingning were higher than those in Guangzhou. Heat waves occurred from June to September in both cities.The effect of the heat wave on hospitalization in the two cities was relatively short and was the greatest at lag- 0 day( RR: 1. 045,95% CI: 1. 005- 1. 165 in Guangzhou; RR: 1. 165,95% CI: 1. 142- 1. 288 in Xingning). The cumulative effects of heat waves on hospitalization were largest at a lag of 0- 1 day; the number of inpatients increased by 2. 6%( 95% CI: 1. 4%- 3. 8%) in Guangzhou and 4. 5%( 95% CI:2. 0%- 6. 0%) in Xingning. Compared with people aged 65 years or below,patients with circulatory system diseases,and male,greater effects were observed in those with respiratory diseases( CER: 4. 6%),aged 75 years and older( CER: 5. 7%),and female( CER: 4. 7%) in Xingning. Conclusion The heat wave increased the risk of hospital admissions in Guangzhou and Xingning. Respiratory diseases,people aged 65 and over,and women are vulnerable to the heat waves.
GA based LQR optimal controller design for double inverted pendulum

Inverted pendulum is a multivariable,fast,non-linear unstable system.In the control methods of inverted pendulum,the LQR method is often adopted because of its stability characteristic.The key of this method is the selection of weighting matrix Q and R.It usually costs lots of time to obtain satisfied results by repeating experiments.So its effective application is restricted.In this paper,the genetic algorithm is applied to design Q and R weighting matrix based on the mathematical model of double inverted pendulum.With its effective intelligent search and the gradual optimization characteristics the Q,R weighting matrix and the state feedback control rate K are obtained.The control results of the double inverted pendulum experiment platform indicate that this method has quick response speed and small overshoot.The optimized parameters make the actual controller stable.Therefore this method has good validity and usability.
Therapeutic surfactant-stripped frozen micelles.

Injectable hydrophobic drugs are typically dissolved in surfactants and non-aqueous solvents which can induce negative side-effects. Alternatives like ‘top-down’ fine milling of excipient-free injectable drug suspensions are not yet clinically viable and ‘bottom-up’ self-assembled delivery systems usually substitute one solubilizing excipient for another, bringing new issues to consider. Here, we show that Pluronic (Poloxamer) block copolymers are amenable to low-temperature processing to strip away all free and loosely bound surfactant, leaving behind concentrated, kinetically frozen drug micelles containing minimal solubilizing excipient. This approach was validated for phylloquinone, cyclosporine, testosterone undecanoate, cabazitaxel and seven other bioactive molecules, achieving sizes between 45 and 160 nm and drug to solubilizer molar ratios 2–3 orders of magnitude higher than current formulations. Hypertonic saline or co-loaded cargo was found to prevent aggregation in some cases. Use of surfactant-stripped micelles avoided potential risks associated with other injectable formulations. Mechanistic insights are elucidated and therapeutic dose responses are demonstrated. The excipients used to solubilise hydrophobic drugs sometimes interfere with drug behaviour or induce adverse side effects once injected. Here, the authors use a low-temperature process to obtain surfactant-stripped micelles with high drug concentration for delivery of a wide range of hydrophobic cargoes.
Dermatologic manifestations of nosocomial infections.

SUMMARY There is no substitute for preventing dermatologic infection in a hospitalized patient by maintaining intact, well nourished skin. The integrity of the integument becomes assaulted on a daily basis from a variety of methods. Measures to lessen this risk can be undertaken, but it may not be totally preventable. The phenomenon of infected desquamated squamous cells being dispersed into the environment by patients and health care workers is one that deserves further study.43 If this proves to be an important factor, hospital spread of bacteria may indeed be unavoidable. It is hoped that this review will serve as a starting point in an area short on clinical data. Further study into this arena is clearly needed.
Urinary Tract Stone Incidence in the U.S. Veteran Population

The United States veteran population is comprised of primarily older males, a population at risk for urinary-tract stone disease. In response to that need, The National Veterans Administration Crystal Identification Center (NVACIC) was established in 1983 at the Clement J. Zablocki VA Medical Center in Milwaukee, Wisconsin for the characterization of all crystal-containing Veteran patient samples using high-resolution x-ray crystallographic techniques. Of all samples submitted for analysis, 96.5% were urinary tract calculi.
RADIO-FREQUENCY IMAGING IN GEOPHYSICAL APPLICATIONS.

AbstractX-ray reconstructive imaging (tomography) has found an incredible range of applications, from microscopy to astrophysics. Radio-frequency imaging has a similar potential which has not yet been fully realized: geophysical uses alone include exploration, mining, and underground process monitoring. Reconstructive imaging to date has been largely based on the explicit assumption of straight line propagation between source and receiver. This is much more valid for X-rays than for radio waves in an underground environment, and the relative lack of success of RF imaging can be largely attributed to this simplification. In this paper, a geophysical imaging technique is being proposed which reconstructs the unknown environment from cross-borehole measurements of RF electromagnetic wave transmission. Unlike some previous methods which assume straight-ray transmission, the technique explicitly accounts for refraction and first-order reflection in the reconstruction process. Several examples of images of unde...
In-bed posture classification using deep autoencoders

Pressure ulcers are high prevalence complications among bed-bound patients which are not only extremely painful and difficult to treat, but also impose a great burden in our health-care system. We target automatic posture detection which is a key module in all pressure ulcer monitoring platforms. Using data collected from a commercially-available pressure mapping system, we applied deep neural networks to automatically classify in-bed posture using features extracted from the histogram of gradient technique. High accuracy of up to 98% was achieved in classifying five different in-bed postures for more than 60,000 pressure images.
A Low-Power Digitizer for Back-Illuminated 3-D-Stacked CMOS Image Sensor Readout With Passing Window and Double Auto-Zeroing Techniques

This paper presents a high-performance digitizer based on column-parallel single-slope analog-to-digital converter (SS-ADC) topology for readout of a back-illuminated 3-D-stacked CMOS image sensor. To address the high power consumption issue in high speed digital counters, a passing window (PW)-based hybrid counter topology is proposed. In this approach, the memory cells in the digital counters of SS-ADCs are disconnected from the global bus during non-relevant timing. To address the high column fixed pattern noise (FPN) under bright illumination conditions, a double auto-zeroing (AZ) scheme is proposed. In this technique, the AZ process is employed twice at reset and signal level, respectively. The double AZ scheme not only allows the comparator to serve as a crossing detector around the common-mode level, but it also enables low-voltage comparator design. The proposed techniques are experimentally verified in a prototype chip designed and fabricated in the TSMC 40 nm low-power CMOS process. The PW technique saves 52.8% of power consumption in the hybrid digital counters. Dark/bright column FPN of 0.0024%/0.028% is achieved employing the proposed double AZ technique for digital correlated double sampling. A single-column digitizer consumes a total power of 66.8 $\mu \text{W}$ and occupies an area of 5.4 $\mu \text{m} \times $ 610 $\mu \text{m}$ .
Dynamic regulation of Nanog and stem cell-signaling pathways by Hoxa1 during early neuro-ectodermal differentiation of ES cells

Homeobox a1 (Hoxa1) is one of the most rapidly induced genes in ES cell differentiation and it is the earliest expressed Hox gene in the mouse embryo. In this study, we used genomic approaches to identify Hoxa1-bound regions during early stages of ES cell differentiation into the neuro-ectoderm. Within 2 h of retinoic acid treatment, Hoxa1 is rapidly recruited to target sites that are associated with genes involved in regulation of pluripotency, and these genes display early changes in expression. The pattern of occupancy of Hoxa1 is dynamic and changes over time. At 12 h of differentiation, many sites bound at 2 h are lost and a new cohort of bound regions appears. At both time points the genome-wide mapping reveals that there is significant co-occupancy of Nanog (Nanog homeobox) and Hoxa1 on many common target sites, and these are linked to genes in the pluripotential regulatory network. In addition to shared target genes, Hoxa1 binds to regulatory regions of Nanog, and conversely Nanog binds to a 3' enhancer of Hoxa1 This finding provides evidence for direct cross-regulatory feedback between Hoxa1 and Nanog through a mechanism of mutual repression. Hoxa1 also binds to regulatory regions of Sox2 (sex-determining region Y box 2), Esrrb (estrogen-related receptor beta), and Myc, which underscores its key input into core components of the pluripotential regulatory network. We propose a model whereby direct inputs of Nanog and Hoxa1 on shared targets and mutual repression between Hoxa1 and the core pluripotency network provides a molecular mechanism that modulates the fine balance between the alternate states of pluripotency and differentiation.
Interaction between the AAA ATPase p97/VCP and a concealed UBX domain in the copper transporter ATP7A is associated with motor neuron degeneration

The copper-transporting ATPase ATP7A contains eight transmembrane domains and is required for normal human copper homeostasis. Mutations in the ATP7A gene may lead to infantile-onset cerebral degeneration (Menkes disease); occipital horn syndrome (OHS), a related but much milder illness; or an adult-onset isolated distal motor neuropathy. The ATP7A missense mutation T994I is located in the sixth transmembrane domain of ATP7A, represents one of the variants associated with the latter phenotype, and is associated with an abnormal interaction with p97/valosin-containing protein (VCP), a hexameric AAA ATPase (ATPase associated with diverse cellular activities) with multiple biological functions. In this study, we further characterized this interaction and discovered a concealed UBX domain in the third lumenal loop of ATP7A, between its fifth and sixth transmembrane domains. We show that the T994I substitution results in conformational exposure of the UBX domain, which then binds the N-terminal domain of p97/VCP. We also show that this abnormal interaction occurs at or near the cell plasma membrane. The UBX domain has a conserved hydrophobic FP (Phe-Pro) motif, and substitution with di-alanine abrogated the interaction and restored the proper intracellular localization of ATP7A in the trans-Golgi network. Using protein MS, we identified potential coordinating components of the ATP7AT994I–p97 complex, including NSFL1 cofactor (NSF1C or p47) that may be relevant to the pathophysiology and clinical effects associated with ATP7AT994I. Our study represents the first report of p97/VCP binding to a UBX domain that is not normally exposed, resulting in an aberrant protein–protein interaction leading to motor neuron degeneration.
Acoustic correlates of prominence in Yawarana

Yawarana (Cariban) is a critically endangered language of Venezuela, with 20–30 speakers and little published research beyond wordlists. In these wordlists, orthographic indications of stress and/or vowel length are inconsistent. As part of our language documentation project, we examine acoustic correlates of prominence in Yawarana. Many other languages in the Cariban family have a clear rhythmic stress system, with vowel lengthening and pitch excursion marking prominence; Yawarana does not mark prominence in the same way. Even so, in some situations, native speakers do appear to attend to stress (i.e., when correcting the pronunciation of language learners). Here, we ask what the acoustic correlates of prominence are, paying particular attention to intensity, pitch, and duration information. We are examining over 200 lexical items produced by four native speakers. These items are repeated in isolation, produced in carrier phrases, and produced in narratives and conversations. We compare measures of promi...
Impact of immune checkpoint inhibitor dose on toxicity, response rate, and survival: A pooled analysis of dose escalation phase 1 trials.

3077Background: PK and PD studies demonstrate drug exposure and target saturation of immune checkpoint inhibitors (ICI) at doses below MTD. MTD remains a primary endpoint in ICI phase 1 trials and ...
Factor structure of the DSM-IV criteria for college students using the Adult Behavior Checklist.

This study evaluated the factor structure of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994) criteria for attention-deficit/hyperactivity ...
Personal privacy — transatlantic perspectives: European and American privacy: commerce, rights and justice — part II.

Abstract In a commercial context, there are strong moral arguments in favor of personal privacy using either a rights-based analysis or a justice-based analysis. The gap between European and American thinking about legal protection for personal privacy is partially explained by the emphasis that Europeans place on a rights-based approach, and the different way in which that approach is interpreted in the United States. This article suggests that the philosophical gap could be narrowed by placing greater emphasis on moral principles of justice in the European- US privacy dialogue. Part I of this article appeared in the last issue.
Non-Bulk-Like Water on Cellular Interfaces

Given that a major fraction of cellular water is non-bulk-like in its physical properties the question arises: What is the molecular basis of this non-bulk water? As proteins are, by mass, the major solute in the cell it is natural to suspect proteins as the main factor responsible for the non-bulk properties of water in cells. This report reviews possible theories and facts on the origins of this non-bulk-like cellular water. After review of theories in the literature it is concluded that native globular proteins in their free and polymerized state can account for the major fraction of cell water as being non-bulk-like in its physical properties
Dietary Fiber in Nutrition Management of Diabetes

Dietary fiber intake benefits individuals with a wide variety of metabolic conditions or gastrointestinal disorders. In the past decade the advantages of generous fiber intakes have been reported for persons with diabetes (Anderson, 1979; Anderson and Chen, 1979; Anderson and Ward, 1979; Jenkins et al, 1982), hypercholesterolemia (Anderson et al, 1984), hypertriglyceridemia (Anderson, 1980), obesity (Anderson et al., 1980a), or hypertension (Anderson, 1983). Individuals with high levels of dietary fiber intake are less likely to develop coronary heart disease (Morriset al1977; Kromhout et al., 1982; Liu et al., 1982) or colon cancer (Bingham et al., 1979) than their neighbors with low-fiber intakes. The role of dietary fiber in the prevention (Trowell, 1975) and management of diabetes (Anderson, 1979, Anderson and Chen, 1979; Anderson and Ward, 1979) has been studied extensively. This review will examine the effects of dietary fiber intake on glucose and lipid metabolism of lean diabetic individuals.
Perforin, Killer Cells and Gene Transfer Immunotherapy for Cancer

The science of immunology has entered the stage at which a reasonably detailed understanding of molecular mechanisms allows the application of immunological concepts to the treatment of certain diseases. Cytotoxic mechanisms of lymphocytes have been clarified to the point where cogent decisions can be made as to how to exploit them for the treatment of viral diseases and cancer. Granule exocytosis and perforin have been identified as major cytolytic mechanisms in vivo and in vitro in CD8+ T cells and natural killer (NK) cells by the creation of perforin knock-out mice and analysis of their cytotoxic potential. In addition Fas and Fas-ligand-mediated cytolytic mechanisms, which are granule-independent, are mediated by cytotoxic T cells (CTLs). The expression of Fas on the target, however, is required. Independent of Fas and perforin, a third, protein synthesis-independent, Ca2+-dependent cytotoxic mechanism exists in CTLs. The molecular nature of this pathway is not known. Finally, a protein synthesis-dependent, Ca2+-dependent pathway appears to be present in lympholuine-activated killer (LAK) cells.
Sounds Like a Winner: Voice Pitch Influences Perception of Leadership Capacity

It is well-known that non-human animals respond to information encoded in vocal signals, and the same can be said of humans. Specifically, human voice pitch affects how speakers are perceived. As such, does voice pitch affect how we perceive and select our leaders? To answer this question we recorded men and women saying “I urge you to vote for me this November.” Each recording was manipulated digitally to yield a higher- and lower-pitched version of the original. We then asked men and women to vote for either the lower- or higher-pitched version of each voice. Our results show that both men and women select male and female leaders with lower voices. These findings suggest that because women, on average, have higher-pitched voices than men, voice pitch could be a factor that contributes to fewer women holding leadership roles than men. Importantly, and contrary to our expectations, subjects’ characteristics such as political leanings and views on gender equality did not influence the results. As such, while people are free to make their own choices, our results clearly demonstrate that these choices cannot be understood in isolation from biological influences.
Spewing nonsense [or not]: communication competence and socialization in optics and photonics workplaces

This study investigated how managers, entry-level employees, and hiring professionals in the optics and photonics industry socialize each other to enact the communication norms and expectations in ...
Safety and benefits of new techniques and technologies in less invasive mitral valve repair

OBJECTIVE To assess the safety and benefits of new techniques and technologies such as single-dose (del Nido) cardioplegia and suture fasteners (COR-KNOT) in patients undergoing mini-thoracotomy for degenerative mitral valve repair (MVR). METHODS From 2009 to 2016, 252 patients underwent primary isolated degenerative MVR by mini-thoracotomy by a single surgeon. Del Nido cardioplegia was used in 153 patients (61%) and COR-KNOT in 168 (67%). Patient outcomes were compared using propensity-matching separately for del Nido versus Buckberg cardioplegia and COR-KNOT versus knot-pusher. RESULTS There were no operative deaths and 99.2% of the patients had none/trivial mitral regurgitation at discharge. In patients receiving del Nido or Buckberg cardioplegia, occurrence of adverse events was similar. However, aortic cross clamp (AoCC; 54.2 ± 15.7 vs 64 ± 15.8 min; P < 0.0001) and operative room (OR; 308 ± 42.1 vs 336 ± 63 min; P < 0.001) times were shorter with del Nido cardioplegia. In patients receiving COR-KNOT versus knot-pusher, occurrence of adverse events was similar. However, AoCC (54.1 ± 15.2 vs 66.1 ± 15.9 min; P < 0.0001) and OR (311 ± 43.6 vs 336 ± 65.4 min; P < 0.0001) times were shorter with COR-KNOT. Results were similar after matching for both, del Nido versus Buckberg cardioplegia and COR-KNOT versus knot-pusher. CONCLUSION New techniques and technologies, such as del Nido cardioplegia and COR-KNOT, decrease AoCC and OR times without compromising patient safety.
Alternating Decision Trees for Cloud Masking in MODIS and VIIRS NASA Sea Surface Temperature Products

AbstractIdentification and exclusion of clouds from satellite-based infrared fields is critical to achieve accurate retrievals of sea surface temperature (SST). Historically, identification of clou...
Clinical characteristics and outcomes of benign, atypical, and malignant breast adenomyoepithelioma: a single institution's experience.

Abstract Background Breast adenomyoepithelioma (AME) is rare. We sought to evaluate clinical characteristics, treatment, and outcomes of a contemporary patient cohort stratified by histology. Methods We queried health records containing “adenomyoepithelioma” between 2000 and 2018. Histology was confirmed with centralized review and classified into benign, atypical, and malignant. Clinical characteristics, demographics, treatment, and oncologic outcomes were compared. Results Our query yielded 24 patients with adenomyoethelioma. Histologic diagnosis was confirmed in 12 (benign n = 6, atypical n = 3, malignant n = 3). Excision (n = 11) was the usual initial treatment, with margin status available in 10 patients. Mean follow up was 44 months (range 1–138 months) with no local recurrence observed. Two patients with benign AME presented with concurrent contralateral breast cancer, and one with malignant AME died of metastatic AME. Conclusion Wide excision of atypical and malignant AME is recommended as local recurrence when excised completely was not observed. Given metastatic potential of malignant AME, multimodal therapy may be warranted.
Expanding the Teaching Toolbox: Characterizing Utility of a Web-Based Lecture Series in Educating Future Colleagues and Referrers about the Field of IR.

Abstract Opportunities for interventional radiology (IR) education and exposure remain limited at medical institutions without a local IR presence, thereby excluding a medical student population with potential to pursue careers in IR or become referring providers to IR. The purpose of this study was to evaluate the efficacy of a Webinar-based IR elective as an educational tool for outreach to US medical schools lacking local preclinical IR exposure. Our early results indicate that a Webinar-based IR lecture series can serve as an effective method for educating future physicians about the field of IR and when to consult IR for patient management.
Cortical Microstructural Alterations in Mild Cognitive Impairment and Alzheimer’s Disease Dementia

In Alzheimer's disease (AD), neurodegenerative processes are ongoing for years prior to the time that cortical atrophy can be reliably detected using conventional neuroimaging techniques. Recent advances in diffusion-weighted imaging have provided new techniques to study neural microstructure, which may provide additional information regarding neurodegeneration. In this study, we used neurite orientation dispersion and density imaging (NODDI), a multi-compartment diffusion model, in order to investigate cortical microstructure along the clinical continuum of mild cognitive impairment (MCI) and AD dementia. Using gray matter-based spatial statistics (GBSS), we demonstrated that neurite density index (NDI) was significantly lower throughout temporal and parietal cortical regions in MCI, while both NDI and orientation dispersion index (ODI) were lower throughout parietal, temporal, and frontal regions in AD dementia. In follow-up ROI analyses comparing microstructure and cortical thickness (derived from T1-weighted MRI) within the same brain regions, differences in NODDI metrics remained, even after controlling for cortical thickness. Moreover, for participants with MCI, gray matter NDI-but not cortical thickness-was lower in temporal, parietal, and posterior cingulate regions. Taken together, our results highlight the utility of NODDI metrics in detecting cortical microstructural degeneration that occurs prior to measurable macrostructural changes and overt clinical dementia.
Predicting the Impact of Increasing Plug-in Electric Vehicle Loading on Bulk Transmission Systems

This paper proposes a methodology to assess the impact of the increasing penetration of plug-in electric vehicles (PEV) in cascading failures. Our methodology captures the stochastic nature of the charging profiles of PEV and presents an algorithm to generate a PEV charge profile. A pseudo-inverse based cascading failure model and the linearized (DC) power flow equations are used in the framework of a Monte Carlo simulation. Finally, we validate the proposed methodology in the New England IEEE-39 bus test system under different levels of PEV penetration. The results of this paper provide insights to plan the expansion of transmission systems as well as to develop countermeasures to mitigate cascading failures caused by the rising penetration of PEV charging stations.
Siting charging stations for electric vehicle adoption in shared autonomous fleets

Abstract The transportation sector is undergoing three revolutions: shared mobility, autonomous driving, and electrification. When planning the charging infrastructure for electric vehicles, it is critical to consider the potential interactions and synergies among these three emerging systems. This study proposes a framework to optimize charging infrastructure development for increasing electric vehicle (EV) adoption in systems with different levels of autonomous vehicle adoption and ride sharing participation. The proposed model also accounts for the pre-existing charging infrastructure, vehicle queuing at the charging stations, and the trade-offs between building new charging stations and expanding existing ones with more charging ports. Using New York City (NYC) taxis as a case study, we evaluated the optimum charging station configurations for three EV adoption pathways. The pathways include EV adoption in a 1) traditional fleet (non-autonomous vehicles without ride sharing), 2) future fleet (fully autonomous vehicles with ride sharing), and 3) switch-over from traditional to future fleet. Our results show that, EV adoption in a traditional fleet requires charging infrastructure with fewer stations that each has more charging ports, compared to the future fleet which benefits from having more scattered charging stations. Charging will only reduce the service level by 2% for a future fleet with 100% EV adoption. EV adoption can reduce CO2 emissions of NYC taxis by up to 861 Tones/day for the future fleet and 1100 Tones/day for the traditional fleet.
Cancer patients’ perceptions of physicians who use an integrated electronic health record (EHR) approach during clinic visits: A double-blinded randomized clinical trial (RCT).

e24201Background: Our previous RCT found that cancer patients prefer and positively perceive physicians who communicate face-to-face as compared to using the EHR. However, the use of EHR in the exa...
Acute Motor-Sensory Axonal Neuropathy Associated with Systemic Lupus Erythematosus: A Challenge in Treatment (P1.2-047)

Objective: To present an unusual case with complex management of acute motor-sensory axonal neuropathy (AMSAN) associated with systemic lupus erythematosus (SLE). Background: AMSAN is a variant of Guillian-Barre syndrome. The standard treatment is intravenous immunoglobulin (IVIg) or plasmapheresis. SLE is a multisystem autoimmune disease which is generally treated by immunosuppressant. The association of AMSAN and SLE is rarely reported. Herein, we described the clinical presentation and complex management in the case of AMSAN with SLE. Design/Methods: NA Results: A previously healthy 72-year-old Caucasian man presented with rapidly progressive paraparesis and dysesthesia and bilateral knees and finger pain with morning stiffness. He had no history of recent fever, diarrhea or vaccination. Neurological examination showed complete quadriplegia and areflexia. Hyperesthesia was noted in all extremities. Cranial nerves were intact. Pain with passive movement and tenderness were noted in knees and joints of the fingers. Other systemic examination was normal. Blood work showed elevated erythrocyte sedimentation rate, antinuclear antibody, and anti-dsDNA titer. Antineutrophil cytoplasmic antibody and paraneoplastic antibodies were negative. Cerebrospinal fluid showed albuminocytologic dissociation. Nerve conduction study was suggestive for acute diffuse axonal sensorimotor polyneuropathy (motor predominant). Initially, the patient was treated by IVIg without significant response. Because the patient met the systemic lupus international collaborating clinic diagnostic criteria for SLE, intravenous methylprednisolone and cyclophosphamide were given. Joint pain was resolved. The motor strength was slowly improving. Ganglioside antibody panel reported positive GD1b antibody with negative GM1, GD1a and GQ1b. Ten days later, the weakness started worsening. After plasmapheresis, the patient was stabilized, then slowly improving. The outcome at 3 and 6 months will be presented at the conference. Conclusions: The association of AMSAN and SLE is poorly understood. Combination of IVIg and/or plasmapheresis with immunosuppression may benefit in AMSAN associated with SLE. Disclosure: Dr. Thakolwiboon has nothing to disclose. Dr. Karukote has nothing to disclose.
What Makes Teachers Well? A Mixed Methods Study of Special Education Teacher Well-being

Using a longitudinal convergent-mixed-methods approach, researchers explored how secondary special education teachers understand and experience well-being in their work as educators. Researchers were interested in how teachers’ reported levels of well-being, as well as interpretations of well-being, shifted over the course of the school year. Evidence from this study suggests that teachers’ subjective experiences matter, but the contexts in which they teach can shift their experiences, which may be connected to overall well-being. Simply reducing stressors and/or burnout will not necessarily result in improved well-being for teachers. School-wide efforts to improve relationships within the school building, providing space for teacher leadership, explicitly naming shared values, and recognizing the emotional calendar of the school year may facilitate teachers’ well-being.
The Data Revolution: Cloud Computing, Artificial Intelligence, and Machine Learning in the Future of Sports

Chase argues that data is the currency by which competitive advantage is won and lost. Those who find creative ways to unlock and harness it—largely through employment of Artificial Intelligence, Machine Learning, and Cloud Computing, which she discusses in turn—will be the champions of tomorrow. Use of these technologies will enable a waterfall of new abilities: Teams will better identify talent and optimize training protocols. Game strategy, team lineups, and player archetypes will be created and simulated in virtual “what if” environments. Fans’ experiences will be increasingly immersive. If these advanced insights could be properly unlocked, understanding that Artificial Intelligence and Machine Learning are tools with defined limits and biases, data will transform sport and push the limits of human performance.
The potential for biomimetic application of rumination to bioreactor design

Abstract Pretreatment of biomass feedstocks is considered necessary to increase their conversion to biofuels and other bioproducts. However, even the best chemical and physical pretreatments have disadvantages that make the development of alternative strategies to improve biomass fermentability a worthy pursuit. An interesting natural process is that of rumination, by which ruminant animals regurgitate their food for re-chewing to reduce particle size, increase surface area, and accelerate its biodegradation by the animal's mutualistic microbial community. Detailed examination of the process reveals that it is a unique, unusually effective, and energy-efficient type of physical treatment of fibrous biomass. Effectiveness and energy efficiency are gained by several unappreciated aspects of the process, including: full wetting of the biomass prior to its exposure to re-chewing; a hypsodont dentition pattern and jaw movement designed to maximize shearing and delamination (rather than cutting) of the biomass; and an effective feed sorting mechanism that results in a preferential processing of the larger particles that are in need of further grinding, rather than smaller particles whose additional grinding would provide little benefit. These nuances of the rumination process suggest designs for accomplishing similar particle size reduction and surface area increases within bioreactors during cellulosic biomass fermentation (“co-treatment”). While the rumination process has evolved within the context of allowing the ruminant animal to exploit widely available but highly fibrous feeds, it has the potential for broad applicability and improved efficiency for industrial conversion of cellulosic biomass by both pure and mixed cultures.
Stellar Bowshocks in the Northern Arm of the Galactic Center: More Members and Kinematics of the Massive Star Population

We present new 2.2 micron diffraction-limited images from the W. M. Keck 10 m and Gemini 8 m telescopes of the cool Galactic Center sources, IRS 1W, 5, 8, 10W, and 21 along with new proper motions for IRS 1W, 10W and 21. These observations were carried out to test the bowshock hypothesis presented by Tanner et al. as an alternative to a very recent (10^4 yr) epoch of star formation within the tidal stream of gas and dust known as the Northern Arm. Resolved asymmetric structure is detected in all the sources, with bowshock morphologies associated with IRS 1W, 5, 8 and 10W. For IRS 1W and 10W, there is an agreement between the position angle of the asymmetry and that of the relative velocity vector of the near-infrared source with respect to the Northern Arm gas strengthening the bowshock hypothesis. We therefore conclude that the observed morphology is indeed a bowshock generated by sources plowing through the Northern Arm. Furthermore, the large extent of the resolved structures (310-1340 AU) along with their luminosities (~10^4-5 Lsun) suggests that their central sources are Wolf-Rayet stars, comparable to the broad He emission-line stars, which have strong winds on the order of 1000 km/s. The bowshock morphology, along with the proper motion measurements, provide three-dimensional orbital solutions for this enigmatic class of objects; IRS 1W and 10W have orbital planes that are consistent with that of the putative clockwise plane which has been proposed as a solution for the He I emission-line stars. While these observations eliminate the need to invoke star formation within the Northern Arm, they increase by 14% the total known population of massive, young stars with strong winds, whose origin remains unexplained in the context of the nearby supermassive black hole.
An 8.1 ENOB 10bit 400MS/s Pipelined ADC Using SAR and Sub-Ranging Flash

This paper proposes a pipeline ADC consisting of a first stage SAR ADC and a second stage Flash ADC. This ADC has a 10-bit resolution at 0.9 V power supply voltage and operates at 400 MS/s. The first stage SAR ADC is 6bit resolution, operates in an asynchronous type, and calibrates the offset of the internal comparator before normal operation of the ADC. The second stage Flash ADC outputs 5 bit digital outputs, and a sub-ranging scheme is used to reduce the number of pre-amplifier required. This prototype ADC is manufactured using 28nm CMOS process and consumes 4.55mW power at 400MS/s operation at 0.9V supply voltage, and the chip area is 0.011mm2. The SNDR of 50.5 dB at input frequency 1 MHz, the SNDR of 45.2 dB at 100 MHz input was obtained.
A Yoga Intervention for Young Children: Self-Regulation and Emotion Regulation

Yoga-based interventions have been implemented in schools and demonstrated promising results on students’ self-regulation outcomes. Nevertheless, there is limited literature on the effects that yoga may have for children in the early primary grades, despite the evidence demonstrating that this is an opportune period in development for early self-regulation. Few studies have focused on young children living in the context of economic difficulty, which can hinder children’s development of self-regulatory skills and educational trajectories. The effects of an eight-week yoga intervention on economically disadvantaged pre-kindergarten and kindergarten children’s self-regulation and emotion regulation were examined via a paired within-subjects comparison study. Nine classrooms were assigned to the yoga intervention (Treatment First, TxFirst; n = 90) or a wait-list control group (Treatment Second, TxSecond; n = 64). All children were assessed at pre-intervention (Time 1), post-intervention assessment for TxFirst (Time 2), and post-intervention assessment for TxSecond (Time 3). Children demonstrated significant predicted gains on a behavioral task of self-regulation and declines in teacher-rated submissive venting and total behavior problems. Implications for future research are discussed, with a focus on including follow-up assessments and multiple dimensions of fidelity of implementation.
Towards Love as Life Praxis: A Black Queer and Feminist Pedagogical Orientation.

On April 21, 2021, after 32 days of criminal court proceedings, American citizens and the international (global) community anxiously awaited the jury’s decision in Derek Chauvin’s trial for murderi...
Individual's pretreatment psychological symptoms and progress in couples therapy: A person-centered analysis.

This study examined how individual pretreatment symptoms (depression and anxiety) predicted longitudinal, relational processes in couples therapy (the therapeutic alliance and couple satisfaction). This study included 99 heterosexual couples receiving systemic couples therapy. Partners reported their individual pretreatment symptoms of depression and anxiety before intake. Each member reported their therapeutic alliance with the therapist at the end of sessions 2-8, as well as their couple satisfaction before intake and at the end of sessions 4 and 8. A Latent Profile Analysis revealed four profiles characterizing couples on their pretreatment psychological symptoms, namely both higher (where both members of the couple had higher depressive and anxiety symptoms), female higher, male higher, and both lower profiles. Furthermore, longitudinal, dyadic multilevel models revealed that men in male higher, female higher, and both higher profiles had higher initial alliance levels, compared to men in the both lower profile. In contrast, only female partners in the both higher profile had a higher initial therapeutic alliance than those in the both lower profile. Men in the both higher profile had faster reductions in their alliance, whereas other profiles did not predict changes in male or female alliance. Additionally, the male higher and both higher profiles predicted a lower initial level of couple satisfaction in males but not females. The profiles did not predict changes in couple satisfaction, which may be a result of lowered power due to missing data. Findings were discussed in the context of systemic family theory, with clinical implications for distressed couples.
The Association of Refractive Error with Glaucoma in a Multiethnic Population.

Purpose To evaluate the association between refractive error and the prevalence of glaucoma by race or ethnicity. Design Cross-sectional study. Participants Kaiser Permanente Northern California Health Plan members with refractive error measured at 35 years of age or older between 2008 and 2014 and with no history of cataract surgery, refractive surgery, or a corneal disorder. Methods We identified 34 040 members with glaucoma or ocular hypertension (OHTN; cases) and 403 398 members without glaucoma (controls). Glaucoma cases were classified as primary angle-closure glaucoma (PACG); 1 of the 4 forms of open-angle glaucoma: primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), pigmentary glaucoma (PIGM), and pseudoexfoliation glaucoma (PEX); or OHTN. Refractive error, expressed as spherical equivalent (SE), was coded as a continuous trait and also as categories. Logistic regression analyses were used to estimate the association between refractive error and the prevalence of glaucoma overall and in specific racial or ethnic groups. Main Outcome Measures The association between refractive error and glaucoma subtypes evaluated as odds ratios (ORs) with 95% confidence intervals (CIs). Results In controls, the mean SE was −0.59 diopters (D) (standard deviation, 2.62 D). Each 1-D reduction in SE was associated with a 22% decrease in the odds of PACG (OR, 0.78; 95% CI, 0.77–0.80) and with increases in the odds of open-angle glaucoma ranging from 1.23 (95% CI, 1.20–1.26) for PIGM, to 1.07 (95% CI, 1.03–1.11) for PEX, and to 1.05 (95% CI, 1.04–1.06) for OHTN. In addition, we observed a stronger association between myopia and POAG among non-Hispanic whites (OR, 1.12; 95% CI, 1.11–1.13) and NTG among Asians (OR, 1.17; 95% CI, 1.15–1.20) and non-Hispanic whites (OR, 1.19; 95% CI, 1.15–1.22). Conclusions Myopia was associated with an increased prevalence of all forms of open-angle glaucoma and OHTN, whereas hyperopia was associated with a substantially increased prevalence of PACG. Although high myopia is a strong risk factor for glaucoma subtypes, low and moderate myopia also have a significant effect on glaucoma risk. Additionally, there were moderate racial differences in the association of myopia with the risk of POAG and NTG.
SECTION 6.3 – Micromechanically Inspired Continuous Models of Brittle Damage

The continuum models of damage evolution that are based on the micromechanics of damage are applicable to deformations during which the irreversible changes of microstructure are related primarily to the random site nucleation of microcracks and their stable growth. This class of deformation is typical of materials with inferior cohesive strength and heterogeneous microstructure at any state of stress; or all microstructures in the absence of long-range tensile stresses. These two materials are known as being damage-tolerant and damage-sensitive, respectively. The damage in the form of microcracks may be attributed to manufacturing processes, environmental causes, applied, and loads. In comparison to the determination of statistical distributions of microcracks, the measurement of effective compliance is rather simple. The thermodynamic force conjugated to the damage parameter is related to the elastic energy release rate. These facts provide the connection between the damage and fracture mechanics and may be used in the experimental measurements of damage needed to determine the model parameters. The described model in the chapter is applicable to quasi-static deformations at relatively small microcrack densities, especially when a damage-sensitive material is subjected to large-range tensile stresses.
Elicited Asynchronies in Recorded Performances of Chopin’s Mazurkas

Studies of duration in music performance since the 1980s have focused on the role of duration in the communication of musical structure, namely grouping and metric structure. This article posits a broader view of duration in performance, namely that performers choose durations to facilitate or inhibit listener-performer synchronicity. Listeners who maintain synchronicity are continually rewarded for making accurate predictions of when events will happen, and thus the loss of synchronicity might hazard feelings of frustration or isolation. Performers, by choosing durations that are difficult to predict, can therefore enlist these feelings in dynamic narratives of synchronicity that augment trajectories in the score. The article explores two such narratives, found in seventeen participants’ attempts to synchronize to two idiosyncratic renditions of passages of Chopin’s mazurkas. By ascribing significance not only to the choices of performers and composers but also to how individual listeners attend to those choices, the article aims to widen the circle of agencies ascribed with the ability to affect the meaning of musical works.
A comprehensive radiometric validation protocol or the CERES Earth radiation budget climate record sensors

The CERES Flight Model 1 and 2 instruments were launched aboard NASA's Earth Observing System (EOS) Terra Spacecraft on December 18, 1999 into a 705 Km sunsynchronous orbit with a 10:30 a.m. equatorial crossing time. These instruments supplement measurements made by the CERES Proto Flight Model (PFM) instrument launched aboard NASA's Tropical Rainfall Measuring Mission (TRMM) spacecraft on November 27, 1997 into a 350 km, 38-degree mid-inclined orbit. An important aspect of the EOS program is the rapid archival and dissemination of datasets measured by EOS instruments to the scientific community. On September 22, 2000 the CERES Science Team voted to archive the Edition 1 CERES/Terra Level 1b and Level 2 and 3 ERBE-Like data products. These products consist of instantaneous filtered and unfiltered radiances through temporally and spatially averaged TOA fluxes. CERES filtered radiance measurements cover three spectral bands including shortwave (0.3 to 5 /spl mu/m), total (0.3 to <100 /spl mu/m) and an atmospheric window channel (8 to 12 /spl mu/m). The current work summarizes both the philosophy and results of validation efforts undertaken to quantify the quality of the Terra data products as well as the level of agreement between the Terra and TRMM datasets.
Functional assessment of chronic obstructive pulmonary disease.

Purpose: To describe available methods for assessing functional capacity in persons with chronic obstructive pulmonary disease (COPD). Data sources: An extensive literature review is used to provide pertinent information. Conclusions: COPD disease affects millions of Americans and is physically and psychologically distressing. The hallmark of chronic obstructive pulmonary disease is irreversible airflow limitation and dyspnea. Dyspnea is a major contributor to decreased exercise capacity and functional status in this population. Understanding the methods to complete a functional assessment is important for all practitioners caring for this population. Implications for practice: This paper provides an overview of current methods used to assess functional status, including pulmonary function testing, exercise testing, and anthropomorphic and self-report measurements. In addition, there is discussion of the indications and contraindications for exercise testing in chronic obstructive pulmonary disease and the clinical significance of performing a global composite of functional ability.