cssi/SciSciGPT-SciSciNet huggingface dataset:
Analysis of Heat-Driven Jet-Pumped Cooling System for Space Thermal Management

Thesolarintegratedthermalmanagementandpowercycleisanewsystemthatcombinesathermalmanagement cycle and a power producing cycle into a single self-contained unit. The system is powered entirely by solar thermalinputvia a concentrating solarcollector.A jetpumpprovides thecompression in thethermal management subsystem, reducing vibration and weight while increasing reliability. Other advantages of the system include constant temperaturecooling, reduced number of system components, theability to use a singleworking e uid, and the incorporation of a waste heat recovery unit. The methods used to analyze the jet pump and the overall system are described separately and in detail. Performance curves based on these analyses are then discussed.
Domain Engineering Methodology

Domain Engineering Methodology aims to improve the communication and coordination of architecting complex System-of-systems (SoS) for Network Centric Warfare (NCW). The DEM identifies best-of-breed techniques across a variety of processes to derive a methodology that concentrates on architectures. This enables Projects and individuals to better collaborate on architectural efforts with improved consistency to produce quality engineering artifacts. This paper examines the approach and results of the research.
Self-Management as a Mediator of Family Functioning and Depressive Symptoms With Health Outcomes in Youth With Type 1 Diabetes

This study examined the relationship of family functioning and depressive symptoms with self-management, glycemic control, and quality of life in a sample of adolescents with type 1 diabetes. It also explored whether self-management mediates family functioning, depressive symptoms, and diabetes-related outcomes. Structural equation modeling was used to estimate parameters in the conceptual causal pathway and test mediation effects. Adolescents (n = 320) were primarily female (55%), younger adolescents (58%), and self-identified as White (63%). Self-management mediated the relationship between family conflict, family warmth-caring, parent guidance-control, and youth depressive symptoms with glycosylated hemoglobin (A1C). In addition, self-management mediated the relationship between family conflict and youth depressive symptoms with quality of life. Supporting optimal family functioning and treating elevated depressive symptoms in adolescents with type 1 diabetes has the potential to improve self-management, glycemic control, and quality of life.
Major Advances in Genetic Evaluation Techniques

The past quarter-century in genetic evaluation of dairy cattle has been marked by evolution in methodology and computer capacity, expansion in the array of evaluated traits, and globalization. Animal models replaced sire and sire-maternal grandsire models and, more recently, application of Bayesian theory has become standard. Individual test-day observations have been used more effectively in estimation of lactation yield or directly as input to evaluation models. Computer speed and storage are less limiting in choosing procedures. The increased capabilities have supported evaluation of additional traits that affect the net profitability of dairy cows. The importance of traits other than yield has increased, in a few cases due to an antagonistic relationship with yield. National evaluations combined internationally provide evaluations for bulls from all participating countries on each of the national scales, facilitating choices from among many more bulls. Selection within countries has increased inbreeding and the use of similar genetics across countries reduces the previously available outcross population. Concern about inbreeding has prompted changes in evaluation methodology and mating practices, and has promoted interest in crossbreeding. In just the past decade, distribution of genetic evaluations has gone from mailed paper or computer tapes for a limited audience to publicly accessible, request-driven distribution via the Internet. Among the distributed information is a choice of economic indices that combine an increasing array of traits into numbers reflecting breeding goals under different milk-pricing conditions. Considerable progress in genomics and the mapping of the bovine genome have identified markers for some deleterious recessive genes, but broader benefits of marker-assisted selection are still in the future. A possible exception is the proprietary use of DNA testing by semen producers to select among potential progeny test bulls. The collection and analysis of industry-wide data to evaluate genetic merit will continue to be the most important tool for genetic progress into the foreseeable future.
Do potatoes and tomatoes have a single evolutionary history, and what proportion of the genome supports this history?

Background Phylogenies reconstructed with only one or a few independently inherited loci may be unresolved or incongruent due to taxon and gene sampling, horizontal gene transfer, or differential selection and lineage sorting at individual loci. In an effort to remedy this situation, we examined the utility of conserved orthologous set (COSII) nuclear loci to elucidate the phylogenetic relationships among 29 diploid Solanum species in the sister clades that include tomato and potato, and in Datura inoxia as a far outgroup. We screened 40 COSII markers with intron content over 60% that are mapped in different chromosomes; selected a subset of 19 by the presence of single band amplification of size mostly between 600 and 1200 bp; sequenced these 19 COSII markers, and performed phylogenetic analyses with individual and concatenated datasets. The present study attempts to provide a fully resolved phylogeny among the main clades in potato and tomato that can help to identify the appropriate markers for future studies using additional species.
RECONSIDERING THE EMPLOYMENT INTERVIEW: A REVIEW OF RECENT LITERATURE AND SUGGESTIONS FOR FUTURE RESEARCH

Literature since the last comprehensive review of research on the employment interview is summarized, and suggestions for future studies in this area are described. Major changes in findings regarding the validity of the interview, the impact of applicant sex, and the effect of interviewer characteristics/behavior on applicant reactions, as well as other issues, are reported. Contrary to the widely held belief that the interview has low validity, recent research indicates at least modest validity for this selection tool. Conversely, the effect of the campus interview on applicant reactions has been seriously questioned. Researchers are urged to examine several areas in social psychology, including the literature on attitudes-intentions-behavior, the elaboration likelihood model, and theories of discrimination to achieve greater understanding of the employment interview.
National Security and Rangelands

Depletion of fossil fuels and global warming could drastically reduce world food production. Conserving and improving rangelands is important, because they likely will play an increased role in meeting world food needs. DOI:10.2458/azu_rangelands_v29i5_holechek2
Using an Error Detection Strategy for Improving Web Accessibility for Older Adults

The ability to use the Internet can provide an important contribution to an older adult's quality of life. Communication via email with family, friends and service providers has become a critical factor for improving ones ability to cope with modern society as individual's age. The problem is that as users age, natural physical and cognitive impairments make it more difficult for them to use the required technology. The present study investigates the use of error detection as a means of improving web access amongst older adults. Specifically, error detection strategies are compared to observation as a means of identifying the impairments of Internet users.
Skeletal Muscle Mass Recovery from Atrophy in IL-6 Knockout Mice

Aim Skeletal muscle interleukin-6 (IL-6) expression is induced by continuous contraction, overload-induced hypertrophy and during muscle regeneration. The loss of IL-6 can alter skeletal muscle’s growth and extracellular matrix remodeling response to overload-induced hypertrophy. IGF-1 gene expression and related signaling through Akt/mTOR is a critical regulator of muscle mass. The significance of IL-6 expression during the recovery from muscle atrophy is unclear. This study’s purpose was to determine the effect of IL-6 loss on mouse gastrocnemius (GAS) muscle mass during recovery from hindlimb suspension (HS)-induced atrophy.
Collision-induced spin exchange of alkali-metal atoms with 3 He: An ab initio study

We present a rigorous quantum study of spin-exchange transitions in collisions of the alkali-metal atoms with $^{3}\text{H}\text{e}$ in the presence of an external magnetic field. Using accurate ab initio interaction potentials, we obtain refined estimates for the Fermi contact interaction constants for complexes of Na, K, and Rb atoms with $^{3}\text{H}\text{e}$. Ab initio calculations show that the Fermi contact interaction in $\text{Li-}^{3}\text{H}\text{e}$ varies more slowly with internuclear distance than predicted by the atomic model [R. M. Herman, Phys. Rev. 37, A1062 (1965)]. The calculated spin-exchange rate constants for Na, K, and Rb atoms in a gas of $^{3}\text{H}\text{e}$ are in good agreement with experimental data. Our calculations demonstrate that at a temperature of 0.5 K, collision-induced spin exchange of the alkali-metal atoms occurs at a very slow rate of $\ensuremath{\sim}{10}^{\ensuremath{-}22}\text{ }{\text{cm}}^{3}/\text{s}$, suggesting potential applications in cryogenic cooling, precision spectroscopy, and quantum optics.
Additional Tyrosine Kinase Inhibitors in Renal Cell Carcinoma

The biology of clear-cell renal cell carcinoma (RCC) supports that anti-angiogenic agents may have therapeutic effect. Indeed, several agents have been shown to provide robust response rates and progression-free survival advantages over historic therapy. In addition, several newer agents are being tested in metastatic RCC. These agents including pazopanib, AZD2171 and PTK787 have demonstrated preclinical activity and have entered clinical trials. These novel agents are likely to add to the therapeutic armamentarium in RCC.
The formation of new bursae with cellophane.

1. Cellophane was effective in the formation of a new subdeltoid bursa in twenty-eight out of thirty cases, in which two previous operations had produced only scar tissue which had obliterated the bursa. In the two cases in which new bursae were not formed, the cellophane had coiled up and had been extruded. 2. Grossly, the new bursae were lined with a shiny, glistening wall. The cellophane lay in this new bursa with no gross evidence of foreign-body reaction in the tissues or of destruction of the cellophane. 3. Microscopically, the lining of these newly formed bursae differed in no way from the lining of normal bursae. There was no microscopic evidence of foreign-body reaction, or of fragmentation or destruction of the cellophane. 4. It is concluded that cellophane is a safe inert substance to use in the tissues. It will allow the formation of a new synovial membrane in areas where scarring is to be expected.
Introducing free volume in strongly dipolar polymers to achieve high dielectric constant

Advances in modern electronics require the development of polymer-based dielectric materials with high dielectric constant, low dielectric loss, and high thermal stability. Fundamental dielectric theory suggests that strongly dipolar polymers have the potential to realize a high dielectric constant. In order to achieve high thermal stability, these polymers should also possess a high glass transition temperature Tg. However, it has been observed in many dielectric polymers that the dielectric constant decreases markedly at temperatures below Tg due to dipole freezing. This study shows that a high energy density polymer with low loss and high operating temperature can be realized in a family of weakly-coupled strongly-dipolar polymers, such as aromatic urea and thiourea. Our experimental results uncover that disorder (or blending) in these polymers leads to a significantly larger free volume at temperatures far below Tg, thereby enabling easier reorientation of dipoles in response to an electric field. The net result is a substantial enhancement in the dielectric constant while preserving low dielectric loss and very high breakdown field. The results here pave the way for creating high energy density polymers with low loss and high operating temperature.
Building Service Brands via Social Identity: Lessons from the Sports Marketplace

This article forwards a framework illustrating the role of social identification in the construction of brand equity for services marketers. Services markets are proposed to exist along an identification continuum based upon levels of consumer commitment and emotional involvement. We illustrate the impact of social identification by focusing on one service industry, the sports marketplace, an industry typified by exceedingly high levels of identification between consumer and market offering. The authors examine four characteristics of the services environment (group experience, history/tradition, physical facility, rituals) that marketers can leverage to enhance consumers’ identification with a service and, ultimately, increase brand equity.
Branch: an interactive, web-based tool for testing hypotheses and developing predictive models

Summary: Branch is a web application that provides users with the ability to interact directly with large biomedical datasets. The interaction is mediated through a collaborative graphical user interface for building and evaluating decision trees. These trees can be used to compose and test sophisticated hypotheses and to develop predictive models. Decision trees are built and evaluated based on a library of imported datasets and can be stored in a collective area for sharing and re-use. Availability and implementation: Branch is hosted at http://biobranch.org/ and the open source code is available at http://bitbucket.org/sulab/biobranch/. Contacts: ude.sppircs@usa or ude.sppircs@doogb Supplementary information: Supplementary data are available at Bioinformatics online.
Semi-supervised learning using ensembles of multiple 1D-embedding-based label boosting

The paper continues the development of the multiple 1D-embedding-based (or, 1D multi-embedding) methods for semi-supervised learning, which is preliminarily introduced by the author in [J. Wang, Semi-supervised learning using multiple one-dimensional embedding based adaptive interpolation, Int. J. Wavelets, Multiresolut. Inform Process. 14(2) (2016) 11 pp.]. This paper puts the development in a more general framework and creates a new method, which employs the ensemble technique to integrate multiple 1D embedding-based regularization and label boosting for semi-supervised learning (SSL). It combines parallel ensemble and serial ensemble. In each stage of parallel ensemble, the dataset is first smoothly mapped onto multiple 1D sequences. On each 1D embedded data, a classical regularization method is applied to construct a weak classifier. All of these weak classifiers are then integrated to an ensemble of 1D labeler (E1DL), which together with a nearest neighbor cluster (NNC) algorithm extracts a newborn labeled subset from the unlabeled set. The subset is believed to be correctly labeled with a high confidence, so that it joins with the original labeled set for the next learning stage. Repeating this process, we gradually obtain a boosted labeled set and the process will not stopped until the updated labeled set reaches a certain size. Finally, we use E1DL to build the target classifier, which labels all points of the dataset. In this paper, we also set the universal parameters for all experiments to make the algorithm as a parameter-free one. The validity of our method in the classification of the handwritten digits is confirmed by several experiments. Comparing to several other popular SSL methods, our results are very promising.
Office of River Protection Advanced Low-Activity Waste Glass Research and Development Plan

The U.S. Department of Energy Office of River Protection (ORP) has initiated and leads an integrated Advanced Waste Glass (AWG) program to increase the loading of Hanford tank wastes in glass while meeting melter lifetime expectancies and process, regulatory, and product performance requirements. The integrated ORP program is focused on providing a technical, science-based foundation for making key decisions regarding the successful operation of the Hanford Tank Waste Treatment and Immobilization Plant (WTP) facilities in the context of an optimized River Protection Project (RPP) flowsheet. The fundamental data stemming from this program will support development of advanced glass formulations, key product performance and process control models, and tactical processing strategies to ensure safe and successful operations for both the low-activity waste (LAW) and high-level waste vitrification facilities. These activities will be conducted with the objective of improving the overall RPP mission by enhancing flexibility and reducing cost and schedule.
Experimental Evaluation of WiFi Active Power/Energy Consumption Models for Smartphones

We conduct an extensive experimental evaluation of a class of WiFi active power/energy consumption models for smartphones that are based on parameters readily available to the upper layers of the protocol stack. We first consider a number of parameters used by previous models and show their limitations. We then focus on a recent approach modeling the active power consumption as a function of the application layer throughput. We study the properties of a previously proposed throughput-based model in relation to other parameters such as the packet size and/or the transport layer protocol, and we evaluate its accuracy under a variety of scenarios that have not been considered in previous studies. Our results show that the model works well in a number of scenarios, with both 802.11n- and 802.11ac-equipped smartphones, and its accuracy can be largely improved with the knowledge of transport layer protocol and packet size. However, such knowledge makes the model more complex and results in largely reduced accuracy in high throughput settings or on hardware different from the one that was used for training. We further discuss a few practical issues related to the measurement and modeling methodology.
INDEPENDENCE OF URINARY ACID MUCOPOLYSACCHARIDES AND TAMM-HORSFALL URINARY MUCOPROTEIN.

SummaryTamm-Horsfall mucoprotein, found with urinary acid mucopolysaccharides prepared by precipitation with cethyltrimethylammonium bromide, is present adventitiously as a coprecipitated impurity rather than as bound moiety. The nature of any actual proteinaceous moiety is unknown. None is immunologically detectable with antisera to proteins of human serum or urine.
POSTBREEDING MOVEMENTS AND HABITAT USE OF ADULT WOOD THRUSHES IN NORTHERN VIRGINIA

We report movements and habitat use during the postbreeding period of ra- dio-tagged adult Wood Thrushes (Hylocichla mustelina) at the United States Marine Corps Base, Quantico, Virginia, from May to October 1993 to 1995. Thirty of 61 radio-tagged adults stayed on the study area up to two months after they finished reproductive activities. During this time they underwent molt. Of these 30 birds, 11 (6 females and 5 males) molted in the same sites where they nested, 4 males moved to stands of deciduous saplings adjacent to their nesting territories, and 15 (4 females and 11 males) moved to molting sites 545 to 7,291 m from their nesting territories. We found no clear patterns that sex or reproductive success were related to the probability of moving away from nesting sites to molt, nor that the lo- cation of molting adults was correlated with the presence of fruiting plants. However, struc- tural attributes of the vegetation that may enhance predation avoidance, such as the number of woody stems, the density of the understory, and the number of deciduous saplings, were significantly higher in molting sites than in nesting sites. We hypothesize that during molt, Wood Thrushes may need access to "safe havens" where protection from predators is en- hanced. Our study strongly suggests that a conservation strategy that focuses on identifying and protecting nesting habitat is inadequate if the events and needs during the postbreeding
The Personal Is Professional Caseworker-Mothers’ Experiences in Child Welfare

Most frontline child welfare workers are female, as are most adult clients. The authors posit that caseworkers who are themselves mothers bring valuable perspectives and expertise to their work; however, their experience and wisdom as mothers is essentially invisible within the profession or at least within the professional literature. This mixed-methods study investigated how the experience of being a mother affects caseworkers’ relationships with client–mothers as well as whether they perceive the child welfare system valuing their unique perspective. Twenty-four participants from diverse positions within the child welfare field completed an interview protocol. Participants overwhelmingly responded that their parenting was informed by their work with families, that their experiences and wisdom as mothers was largely ignored by their agencies, and that their employers’ practices were often not family-friendly. There was variance in participants’ beliefs about whether the client–mothers experienced bias o...
Simultaneous determination of 9 synthetic pigments in foods by high performance liquid chromatography

Objective:To develop a high performance liquid chromatographic method for simultaneous determination of 9 synthetic pigments,including new red,amaranth,ponceau,allura red,erythrosine,tartrazine,sunset yellow,indigotine,brilliant blue in foods.Methods: Beverages,wine samples were heated to remove carbon dioxide or ethanol,sugar products were dissolved in water by heating;meat products and dairy products with high fat and high protein were degreased with petroleum ether,then the pigments in sample solutions were extracted with 4mol/L urea and methanol(1+1),and centrifuged,then the supernatant was taken out and the procedure was repeated until the supernatant became colorless.The supernatant was rotary evaporated to nearly dry,redissolved in water and finally separated on column Cnwsil C18 with gradient elution and detected at 480 ～600nm.Results: The method showed good linearity with r =0.9996 ～0.9999.The average recoveries were 77.6% ～ 111.7% with RSDs of 0.6%～4.2%,the minimum detectable contents were 0.100mg/kg ～0.500mg/kg.Conclusion: The method is simple and practical,accurate and rapid,high sensitive and specific,it can be used for the determination of multiple synthetic pigments in foods.
Must feedback disrupt presence in serious games

Serious games are generally designed with two goals in mind: promoting learning and creating compelling and engaging experiences (sometimes termed a sense of presence). Presence itself is believed to promote learning, but serious games often attempt to further increase pedagogical value. One way to do so is to use an intelligent tutoring system (ITS) to provide feedback during gameplay. Some researchers have expressed concern that, because feedback from an ITS is often extrinsic (i.e., it operates outside of the primary game mechanic), attending to it disrupts players’ sense of presence. As a result, learning may be unintentionally hindered by an ITS. However, the most beneficial conditions of instruction are often counterintuitive; in this paper, we challenge the assumption that feedback during learning hinders sense of presence. Across three experiments, we examined how an ITS that provided extrinsic feedback during a serious game affected presence. Across different modalities and conditions, we found that feedback and other ITS features do not always affect presence. Our results suggest that it is possible to provide extrinsic feedback in a serious game without detracting from the immersive power of the game itself.
Atmospheric science: Unexpected player in particle formation.

Three studies find that a family of organic compounds affects the formation and initial growth of atmospheric aerosol particles in clean air — with implications for our knowledge of the climate effects of aerosols. See Letters p.521 & 527 The effect of atmospheric aerosols on clouds and the radiative forcing of the climate system remains poorly understood. It is thought that nucleation of aerosol particles from atmospheric vapours rarely proceeds in the absence of sulfuric acid. Now two papers in this week’s Nature point to a previously unappreciated role for highly oxygenated molecules (HOMs) in promoting new particle formation and growth, essentially a mechanism that produces aerosols in the absence of pollution. Jasper Kirkby et al. show that aerosol particles can form as a result of ion-induced nucleation of HOMs in the absence of sulfuric acid under conditions relevant to the atmosphere in the CLOUD chamber at CERN. Jasmin Trostl et al. examined the role of organic vapours in the initial growth of nucleated organic particles in the absence of sulfuric acid in the CERN CLOUD chamber under atmospheric conditions. They find that the organic vapours driving initial growth have extremely low volatilities. With increasing particle size, subsequent growth is primarily due to more abundant organic vapours of slightly higher volatility.
Glycoprotein IIb/IIIa blockade inhibits platelet-mediated force development and reduces gel elastic modulus

The effects of GPIIb/IIIa blockade on clot retraction were studied utilizing an instrument which directly measures force produced by platelets. GPIIb/IIIa disruption by calcium chelation, and GPIIb/IIIa blockade by peptides and anti-GPIIb/IIIa antibodies were investigated. One mM EDTA suppressed ADP-induced platelet aggregation by 72% and reduced force developed at 1200 s by 33%. At 234 μM, the tetrapeptide Arg-Gly-Asp-Ser (RGDS) suppressed platelet aggregation by 74%, reduced force at 1200 s by 45% and reduced gel elastic modulus by 19%. At 10 μM, the peptide D-Arg-Gly-L-Asp-L-Try (D-RGDW) completely suppressed platelet aggregation, reduced force development by 38% and reduced gel elastic modulus by 29%. At 0.133 μM, monoclonal anti-GPIIIa antibody (AP-3) reduced force development by 74% and reduced gel modulus by 60%. Murine antiGPIIb/IIIa antibodies 10E5 and 7E3 markedly suppressed force development. At 0.133 μM, 10E5 reduced force by 89% and reduced gel modulus by 67%. At 0.053 μM, 7E3 completely stopped force development and reduced gel modulus by 46%. Platelet aggregation was blocked by 0.027 μM 7E3. Selective GPIIb blockade by antibodies did not affect force development. None of the agents studied altered fibrin structure as monitored by effects on fibrin mass/length ratios. Suppression of platelet aggregation occurred at inhibitor concentrations substantially lower than those required to suppress force development. Complete suppression of platelet aggregation did not assure inhibition of clot retraction probably due to profound platelet activation by thrombin. These results indicate that inhibition of fibrin(ogen) binding to GPIIb/IIIa, either by disruption of GPIIb/IIIa or by competitive blockade, inhibits platelet mediated force development and results in clot structures which are substantially less resistant to deformation by outside forces.
Impacting Health Disparities in Urban Communities: Preparing Future Healthcare Providers for "Neighborhood-Engaged Care" Through a Community Engagement Course Intervention.

It is well known that health disparities exist and that a significant majority of patients who suffer disproportionately from them are lower income, non-white residents of dense, and diverse urban neighborhoods. It is our belief that factors hindering the reduction of health disparities in these neighborhoods are a lack of a framework and preparation needed to engage these communities in identifying specific health care needs. This paper describes one curricular intervention, a graduate level community engagement course, developed within an academic medical center located in an urban setting, that demonstrates promise in effecting change in the extent to which clinicians are able to engage communities and practice “neighborhood-engaged care” with the central goal of mitigating disparities.
Emergency relocation of items using single trips: Special cases of the Multiple Knapsack Assignment Problem

Abstract The Multiple Knapsack Assignment Problem (MKAP) has been solved successfully using heuristics, but important special cases have not yet been dealt with. Motivated by an emergency relocation problem, an optimal polynomial algorithm and a high performing heuristic that take advantage of the special structure are provided for two special cases of the MKAP.
Fuzzy XML Queries and Index

Huge amounts of electronic data are available on the Internet, and XML has been the de-facto standard of information representation and exchange over the Web. The basic structure of XML is tree, and an XML query is often formed as a twig pattern with predicates additionally imposed on the contents or attribute values of the tree nodes. Also, the XML query technique based on index mechanism is developed to further improve the query efficiency. However, the XML fall short in their ability to handle imprecise and uncertain information in many real-world applications, and also the relevant XML query techniques cannot support twig pattern query in fuzzy XML. Currently, fuzzy XML data modeling has been extensively investigated as introduced in Chap. 3. Therefore, topics related to the querying of fuzzy XML can be considered very interesting in the fuzzy XML data context. In this chapter, we focus on the methods of fuzzy XML complex twig queries with predicates and of building index mechanism on fuzzy XML query.
AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay

The c-Myc (MYC) transcription factor is a major cancer driver and a well-validated therapeutic target. However, directly targeting MYC has been challenging. Thus, identifying proteins that interact with and regulate MYC may provide alternative strategies to inhibit its oncogenic activity. In this study, we report the development of a NanoLuc-based protein-fragment complementation assay (NanoPCA) and mapping of the MYC protein interaction hub in live mammalian cells. The NanoPCA system was configured to enable detection of protein-protein interactions (PPI) at the endogenous level, as shown with PRAS40 dimerization, and detection of weak interactions, such as PINCH1-NCK2. Importantly, NanoPCA allows the study of PPI dynamics with reversible interactions. To demonstrate its utility for large-scale PPI detection in mammalian intracellular environment, we have used NanoPCA to examine MYC interaction with 83 cancer-associated proteins in live cancer cell lines. Our new MYC PPI data confirmed known MYC-interacting proteins, such as MAX, GSK3A, and SMARCA4, and revealed a panel of novel MYC interaction partners, such as RAC-α serine/threonine-protein kinase (AKT)1, liver kinase B (LKB)1, and Yes-associated protein (YAP)1. The MYC interactions with AKT1, LKB1, and YAP1 were confirmed by coimmunoprecipitation of endogenous proteins. Importantly, AKT1, LKB1, and YAP1 were able to activate MYC in a transcriptional reporter assay. Thus, these vital growth control proteins may represent promising MYC regulators, suggesting new mechanisms that couple energetic and metabolic pathways and developmental signaling to MYC-regulated cellular programs.
A two-species stage-structured model for West Nile virus transmission

We develop a host–vector model of West Nile virus (WNV) transmission that incorporates multiple avian host species as well as host stage-structure (juvenile and adult stages), allowing for both species-specific and stage-specific biting rates of vectors on hosts. We use this ordinary differential equation model to explore WNV transmission dynamics that occur between vectors and multiple structured host populations as a result of heterogeneous biting rates on species and/or life stages. Our analysis shows that increased exposure of juvenile hosts generally results in larger outbreaks of WNV infectious vectors when compared to differential host species exposure. We also find that increased juvenile exposure is an important mechanism for determining the effect of species diversity on the disease risk of a community.
Optimization-Based AC Microgrid Synchronization

This paper casts the synchronization phenomena in inverter-based ac microgrids as an optimization problem solved using alternating direction method of multipliers (ADMM). Existing cooperative control techniques are based on the standard voting protocols in multiagent systems, and assume ideal communication among inverters. Alternatively, this paper presents a recursive algorithm to restore synchronization in voltage and frequency using ADMM, which results in a more robust secondary control even in the presence of noise. The performance of the control algorithm, for an islanded microgrid test system with additive noise in communication links broadcasting reference signals and communication links connecting neighboring inverters, is evaluated for a modified IEEE 34-bus feeder system. An upper bound for the deviation due to communication noise from the reference set point is analytically derived and verified by the simulated microgrid test system.
Fostering the development of effective person-centered healthcare communication skills: An interprofessional shared learning model

Objective To describe the implementation of an interprofessional shared learning model designed to promote the development of person-centered healthcare communication skills. Participants Master of social work (MSW) and doctor of physical therapy (DPT) degree students. Methods The model used evidence-based principles of effective healthcare communication and shared learning methods; it was aligned with student learning outcomes contained in MSW and DPT curricula. Students engaged in 3 learning sessions over 2 days. Sessions involved interactive reflective learning, simulated role-modeling with peer assessment, and context-specific practice of communication skills. The perspective of patients/clients was included in each learning activity. Activities were evaluated through narrative feedback. Results Students valued opportunities to learn directly from each other and from healthcare consumers. Important insights and directions for future interprofessional learning experiences were gleaned from model implementation. Conclusions The interprofessional shared learning model shows promise as an effective method for developing person-centered communication skills.
Evaluation of deep learning approaches based on convolutional neural networks for corrosion detection

Corrosion is a major defect in structural systems that has a significant economic impact and can pose safety risks if left untended. Currently, an inspector visually assesses the condition of a str...
Your Bribery Is My Networking: Understanding the Meaning of the Exchange of Favors

This chapter focuses on cultural assessments to illustrate the difficulty of evaluating evidence cross culturally. The authors examine the use of bribery and corruption; bribery falls into the category of things that are “illegal” and therefore make the officials suspicious. They assume this is something only people from asylum-sending countries do, though in fact we all do it but we consider it perfectly acceptable and call it “networking” or “making use of contacts.” The authors show that certain kinds of fraudulence are considered offensive and reprehensible (and not credible) even though they are business as usual in the society from which the applicant is fleeing and especially so for someone fleeing persecution.
Chondrosarcoma of the nasal septum.

Chondrosarcoma of the nasal septum is a rarely encountered malignancy. When it does occur, early diagnosis is difficult because patients generally present with common, nonspecific sinonasal complai...
“he is bothyn modyr, broþyr, & syster vn-to me”: Women and the Bible in Late Medieval and Early Modern English Sermons

Examining recent claims that the early modern Bible served as an empowering force for women, this article draws evidence from English sermons designed for quotidinal lay instruction—such as the late medieval sermons of Festial, the sixteenth-century Tudor Homilies, and the seventeenth-century sermons of William Gouge and Benjamin Keach. As didactic religious texts written and delivered by men but also heard and read by women, sermons reveal how preachers rhetorically shaped the contours of women’s agency. Late medieval sermons include women specifically in scripture and authorize women through biblical role models as actively participating within the church. Conversely, early modern sermons were less likely to add women into scripture and more likely to use scripture to limit women by their domestic identities. Thus, through their approaches to biblical texts, medieval preachers present women as more visible and active agents whereas early modern preachers present women as less visible and more limited in their roles—thereby presenting a more complex story of how the Bible affected women across the Reformation.
SCREENING FOR CANCER : USEFUL DESPITE ITS LIMITATIONS

Abstract Effective primary prevention strategies are currently available for only a limited number of types of malignant neoplasms. In the meantime, the most effective intervention for cancer control is screening for the early detection of cancer in otherwise asymptomatic persons. Screening is probably most useful for cancers wherein the stage at diagnosis is clearly related to curability. Early detection by screening has been shown to lead to a better outcome following the treatment of cancers of the breast, cervix, and colon. Screening for cancer also enables preneoplastic states to be detected and treated. Screening programs offer an opportunity to enhance the potential of chemoprevention. New cancer screening tests will soon be developed, including some that will detect known genetic predispositions to cancer. Each new screening test must be critically evaluated in rigorous studies before being embraced or rejected by clinicians and patients. In particular, screening efficacy must be demonstrated as judged by improved survival of those screened.
Safeguarding Children's Well-Being: Voices From Abused Mothers Navigating Their Relationships and the Civil Courts.

Battered mothers often go to great lengths to protect their children from abuse. Most of these efforts play out in private settings such as the home. After their relationships end, women's actions shift to the public sphere for judgment by the courts. Abusers' strategies utilize the courts as another tool with which to call into question and challenge their former partners' parenting. Images of "good mothers" who behave passively are favored by officials who often have incomplete understandings of the dynamics of intimate partner violence and abuse. Existing studies about justice-involved mothers insufficiently portray women's experiences managing both continued abuse from past partners as well as discriminating treatment by the courts. Semistructured interviews with 25 women in the United States who have terminated their abusive relationships reveal strategies of negotiation and resistance used to protect their children both during and after their relationships; the women also recount instances of paternalism and naivete present in civil and criminal courts. While their male abusers seemed to receive leniency from court officials, despite, in some cases, violating judges' direct orders, the women's efforts were sometimes interpreted as recalcitrance and disobedience when they challenged unfair labels, visitation, and custody decisions. This qualitative study contextualizes women's efforts and actions taken to safeguard their children during and after their relationships to highlight women's experiences the courts overlook and misconstrue as well as what happens when women engage with the courts. Policy suggestions include ways to prevent the continued victimization of battered women by the courts, to challenge the pejorative assessment of mother's protective behaviors, and to illuminate court officials' malfeasance and toleration of fathers' tactics.
Validation of the Welch Allyn Pro BP 2000, a professional-grade inflation-based automated sphygmomanometer with arrhythmia detection in a combined pediatric and adult population by ANSI/AAMI/ISO standard testing.

Objective The Welch Allyn Pro BP 2000, an automated sphygmomanometer, was subjected to ANSI/AAMI/ISO testing. Patients and methods The protocol used was the same-arm sequential procedure described in the ANSI/AAMI/ISO 2013 Standard. Eight-eight (53 adults and 35 children aged 3-12 years old) patients completed testing successfully. Arm circumferences ranged from 15 to 49.5 cm. Seven different cuff sizes were used, including two long cuffs. Results All requirements for age, sex, blood pressure (BP), and cuff sizes were fulfilled. The mean±SD was -2.8±6.37 mmHg for systolic BP for criterion 1 and -3.6±6.14 mmHg for diastolic BP. The SD for criterion 2 were 5.29 for systolic BP and 5.75 for diastolic BP. All data passed the Standard's requirements. Conclusion The Pro BP 2000 uses an accurate inflationary algorithm. The time for each inflation/deflation cycle is short, thus improving patient comfort. There is also arrhythmia detection to caution the use of BP values obtained during irregular heart rhythms. The algorithm for the professional-grade Pro BP 2000 is also contained in the Home BP 1700, targeted for home use. This encourages out-of-office self-measurement. The healthcare professional can be confident that the values obtained at different sites are comparable.
Ranked Set Sampling With Unequal Sample Sizes

Abstract In this chapter, we review ranked set sampling with unequal samples for estimating the population mean proposed by Bhoj (2001), ranked set sampling with unequal samples and unequal replications, and ranked set sampling with unequal samples for skew distributions proposed by Bhoj and Kushary (2015, 2016). In addition, we consider new median ranked set sampling suggested by Bhoj (2002), which uses ranked set sampling with unequal samples. The relative precisions of these procedures are better than those based on ranked set sampling and median ranked set sampling. We also discuss the other ranked set sampling procedures suggested by other investigators. Finally, we summarize the applications of ranked set sampling with unequal samples to real data.
On Pain as a Distinct Sensation: Mapping Intensities, Affects, and Difference in ‘Interior States’:

A recent widely reported study found that some participants would prefer to self-administer a small electric shock than be bored. This flawed study serves as a departure point to diagram pain and s...
A conceptualization of militarization in domestic policing

Researchers have investigated the underlying mechanisms and consequences of militarization in law enforcement agencies for decades, yet there is no agreed-upon definition for this concept. Without ...
Gregory of Nazianzus and Q. Aurelius Symmachus: The Conflict between East and West and Elite Self-Presentation in the Later Fourth Century AD Rome and Constantinople

This article compares the literary self-presentations in the De vita sua of Gregory of Nazianzus and the Letters of Symmachus as their respective authors responded to public perceptions in Constant...
Ex Vivo Normothermic Machine Perfusion

Normothermic machine perfusion (NMP) involves perfusing organs ex vivo with normothermic oxygenated blood–based solutions that recreate the physiological environment, thereby tending to decrease the detrimental effects seen with standard cold storage (SCS). Several different NMP platforms exist that are in various stages of development. NMP has the potential to restore normal metabolic physiology, recondition marginal livers, and allow for the assessment of graft viability. The use of NMP for donation after circulatory death (DCD) liver grafts has been of particular interest, given the additional period of damaging warm ischemia these grafts are exposed to compared to donation after brain death (DBD) liver grafts. The present chapter describes the rationale for NMP, as well as providing a summary of pre-clinical and clinical studies that have investigated its application. The various platforms for NMP that have been utilized are also described.
Exciting prospects for detecting late-time neutrinos from core-collapse supernovae

In this theoretical study of successful core-collapse supernovae, the authors provide a detailed model of neutrino emission from the different phases of the transition - explosion to proto-neutron star cooling to late-time formation of either neutron star or black hole. They show that for a supernova in the Milky Way, these copiously produced neutrinos can be detected by current neutrino-detection experiments and used to extract information about the course of the event. The study offers a highly promising program to make full use of a rare core-collapse supernova event to extract as much physics as possible.
Heaps, Continued Fractions, and Orthogonal Polynomials

These notes are an exposition of work of Francon–Viennot, Flajolet and Viennot dealing with combinatorial aspects of the theory of continued fractions. We have added here some of the missing details, some of the proofs that were not given in the original works, and hopefully have corrected some of the errors without creating new ones.
The Impact of China's Official Development Finance on Other Developing Countries

The paper uses a fixed effect model to detect the impact of China’s official development finance program. It shows that China’s official development finance has a positive effect on bilateral trade. Further, China’s official development finance has stronger effect on bilateral trade in democratic recipient countries than in autocratic ones. Likewise, it has stronger effect on bilateral trade in the least developed countries (LDCs) than in middle-income countries (MICs). The results of the paper make the argument for China to direct more official development finance to recipient countries with democratic attributes and at a low level of per capita income, assuming promoting bilateral trade is one of China’s policy objectives. The results of the paper have significant policy implications in international development, because assisting the least developed members with democratic attributes is both in China’s own interest and is broadly consistent with the view held by traditional donors and lenders.
PERFORMANCE OF COAL SLURRY FUEL IN A DIESEL ENGINE

Three slurry fuels containing different concentrations of coal have been tested in a small-bore 4-cylinder diesel engine equipped with modified injectors under various loads and speeds. The relative effectiveness of coal in saving diesel fuel was determined. In general, at higher speeds, exhaust temperatures and smoke increased with the concentration of coal while brake thermal efficiency descreased. The blowby increased significantly in a period of 14 hours at the end of which the fuel pump sized. However, no abnormal wear was observed on injectors and valves. From this preliminary study, it appears that two BTU's of coal will replace about one BTU of diesel fuel in the energy utilization of a slurry fuel of this type, and that the use of slurry fuels will require major engine modifications.
Enzyme inhibition by excess substrate exploitation of kinetic data: I. Linear method

Abstract A reduced form of the Michaelis-Menten equation for enzyme inhibition by excess substrate is described. An iterative procedure permits the precise determination of the optimal concentration. This value is needed to bring the equation to its reduced form. Finally, an application of this technique to experimental data (hydrolysis of acetylcholine by acetylcholinesterase, EC 3.1.17) is illustrated.