cssi/SciSciGPT-SciSciNet huggingface dataset:
Integrating Wildlife Conservation into Urban Planning

Conservation of wildlife at the scale of cities and metropolitan areas, particularly for species that are “urban avoiders,” will require identification, restoration, or preservation of adequate areas of key habitats. Connections between these habitats and to their natural disturbance regimes, all within the context of rapidly changing urban landscapes, must also be maintained. This necessitates the integration of concepts, knowledge, and practice from landscape ecology, conservation biology, and urban planning to successfully engage in local and regional processes that support wildlife-friendly urban growth. In this chapter, we review the broad-scale effects of urbanization on wildlife and relevant principles from conservation biology and urban planning, and propose wildlife zoning within a green infrastructure framework to integrate wildlife conservation into urban planning. Two case studies describing regional-scale urban conservation efforts––the Sonoran Desert Conservation Plan, and the Chicago Wilderness––are offered as examples of integrative, collaborative efforts to conserve wildlife in large metropolitan areas.
WATER QUALITY EFFECTS OF A DREDGING DISPOSAL AREA.

The effect of the settling-basin concept on the water quality associated with a typical disposal site for polluted maintenance dredgings, and the fate of pollutants during a typical dredging and disposal cycle were determined between Aug.20, 1972 and Dec.20, 1972 in Toledo, Ohio. Over 100 samples of slurry influent, overflow effluent, ground water, ambient river water, bottom sediments, and material from the hopper bins and overflow waters were collected and analyzed for standard physical, chemical, and microbiological parameters. It was concluded that only a small fraction of the pollutants are discharged via the overflow weir into the ambient river water; this is attributable to the fact that the polluting substances tend to associate with the solid particles, which settle out of the suspension and are retained within the diked enclosure. The water quality of the effluent resembled that of the ambient river water used as a carrier to pump the dredgings in slurry form from the hopper dredge into the disposal area.
Privileged Communications: When Psychiatrists Envy the Clergy

Although in many states the clergy enjoy certain legal protection of privileged communications that psychotherapists do not, their legal position may have many limitations. Pastoral counselors need to join with other mental health professionals in securing a broadly defined psychotherapist-patient privilege for therapeutic communications.
The Penalisation of Poverty and the rise of Neo-Liberalism

This article explicates and extends the analyses put forth by the author in his book, Prisons of Poverty, which argues that the generalised increase of carceral populations in advanced societies is due to the growing use of the penal system as an instrument for managing social insecurity and containing the social disorders created at the bottom of the class structure by neo-liberal policies of economic deregulation and social-welfare retrenchment. It retraces the steps whereby this ‘neo-liberal penality’ was elaborated in the United States and then diffused throughout the world, but contends that European countries are not blindly following the American road to mass imprisonment: Europe's path to the penal state entails the conjoint intensification of both social and penal treatments of poverty and the activation of the policing functions of welfare services leading to a form of ‘social panoptism’. Only the building of a Europe-wide social state can check the spread of the penalisation of poverty and its deleterious social consequences.
Effect of localized surface-plasmon mode on exciton transport and radiation emission in carbon nanotubes.

We report on a general theoretical approach to study exciton transport and emission in a single-walled carbon nanotube (SWNT) in the presence of a localized surface-plasmon (SP) mode within a metal nanoparticle interacting via near-field coupling. We derive a set of quantum mechanical equations of motion and approximate rate equations that account for the exciton, SP, and the environmental degrees of freedom. The material equations are complemented by an expression for the radiated power that depends on the exciton and SP populations and coherences, allowing for an examination of the angular distribution of the emitted radiation that would be measured in experiment. Numerical simulations for a (6,5) SWNT and cone-shaped Ag metal tip (MT) have been performed using this methodology. Comparison with physical parameters shows that the near-field interaction between the exciton–SP occurs in a weak coupling regime, with the diffusion processes being much faster than the exciton–SP population exchange. In such a...
Characteristics and control strategies of Coordinated Control System (CCS) for supercritical and ultra supercritical power units

Due to the small volume of evaporation area in supercritical and ultra supercritical boilers, the utilization capability of boiler heat-storage is weak. The thermodynamic characteristic of water and steam results in the great nonlinear of heat-storage-coefficient with steam pressure and affects the load response rate of power unit. The object structure of 3-input-3-output CCS has even more strict criteria for the heat balance in load variation and the anti-disturbance capability for load regulation. Based on the comparison and analysis of two different coordinated control strategies in the supercritical units of Lanxi Power Plant and the ultra supercritical units of Yuhuan Power Plant, the improving measures were suggested. This includes to increase the initial gradient of advance fuel flow instruction, separately regulate the sequence and amplitude of fuel and water flow advance instruction, use variable-proportion enthalpy controller, add an overriding feedwater controller to prevent overheat, etc. The coordination and fault-tolerance performance in control process were improved with favorable effect.
Serological investigation on hand foot and mouth disease in healthy population in Jinan

Objective To understand the infection and immune status of the enterovirus CoxA16 and EV71 in healthy population. Methods CoxA16 and EV71 IgG antibodies were detected in serum of health people with the enzyme linked immunosorbent assay( ELISA). Results In 1000 healthy persons covering 10 age groups,the total positive rate of CoxA16 and EV71 IgG antibodies was 84. 9%( 849 /1000). The positive rate of CoxA16 IgG was 78. 6%( 786 /1000),while that of EV71 was 32. 5%( 325/1000),and there was significant statistical differences between the two( χ2= 430. 3,P 0. 05). The double positive rate was 26. 2%( 262 /1000),mainly in children less than 5 years old,accounting for 62. 6%. Conclusion The infection rate of CoxA16 in healthy person was higher than EV71. People was widely susceptible to CoxA16. There was no gender difference or cross immunity in different virus genotypes. Prevention and control of superinfection in young children is the key of HFMD prevention.
Endocrine Evaluation of Adults with Mild Hypospadias

AbstractABSTRACTThe goal of our study was to determine the frequency of endocrine abnormalities in sexually mature men with mild hypospadias. For this purpose we evaluated 16 men 22 to 52 years old with mild hypospadias. All patients had a urethral meatus distal to the penoscrotal junction. Serum concentrations of luteinizing hormone, follicle-stimulating hormone and testosterone were measured in all subjects. Dihydrotestosterone and testosterone precursors also were determined in men who had abnormally elevated levels of luteinizing hormone. The level of serum luteinizing hormone in patients was significantly higher than that of normal men, whereas the levels of serum follicle-stimulating hormone and testosterone were similar to those of normal subjects. Of the 16 men with mild hypospadias 3 had abnormally elevated levels of gonadotropins: 2 had primary gonadal dysfunction (elevated luteinizing hormone and follicle-stimulating hormone with low or normal testosterone) and 1 had hormonal evidence of partia...
Counseling services for Asian, Latino/a, and White American students: Initial severity, session attendance, and outcome.

Objective The current study examined racial/ethnic differences in initial severity, session attendance, and counseling outcomes in a large and diverse sample of Asian American, Latino/a, and White student clients who utilized university counseling services between 2008 and 2012. Method We used archival data of 5,472 clients (62% female; M age = 23.1, SD = 4.3) who self-identified their race/ethnicity as being Asian American (38.9%), Latino/a (14.9%), or White (46.2%). Treatment engagement was measured by the number of counseling sessions attended; initial severity and treatment outcome were measured using the Outcome Questionnaire-45. Results Asian American clients, particularly Chinese, Filipino/a, Korean, and Vietnamese Americans, had greater initial severity compared with White clients. Asian Indian, Korean, and Vietnamese American clients used significantly fewer sessions of counseling than White clients after controlling for initial severity. All racial/ethnic minority groups continued to have clinically significant distress in certain areas (e.g., social role functioning) at counseling termination. Conclusions These findings highlight the need to devote greater attention to the counseling experiences of racial/ethnic minority clients, especially certain Asian American groups. Further research directions are provided. (PsycINFO Database Record
SU‐F‐P‐61: Does It Matter Not to Use Optimization Points at the Apex for Vaginal Cylinder HDR Brachytherapy Planning?

Purpose: To test the impact of the use of apex optimization points for new vaginal cylinder (VC) applicators. Methods: New “ClickFit” single channel VC applicators (Varian) that have a different top thicknesses but the same diameters as the old VC applicators (2.3 cm diameter, 2.6 cm, 3.0 cm, and 3.5 cm) were compared using phantom studies. Old VC applicator plans without apex optimization points were also compared to the plans with the optimization points. The apex doses were monitored at 5 mm depth doses (8 points) where a prescription dose (Rx) of 6Gy was prescribed. VC surface doses (8 points) were also analyzed. Results: The new VC applicator plans without apex optimization points presented significantly lower 5mm depth doses than Rx (on average −31 ± 7%, p <0.00001) due to their thicker VC tops (3.4 ± 1.1 mm thicker with the range of 1.2 to 4.4 mm) than the old VC applicators. Old VC applicator plans also showed a statistically significant reduction (p <0.00001) due to Ir-192 source anisotropic effect at the apex region but the % reduction over Rx was only −7 ± 9%. However, by adding apex optimization points to the new VC applicator plans, the plans improved 5 mm depth doses (−7 ± 9% over Rx) that were not statistically different from old VC plans (p = 0.923), along with apex VC surface doses (−22 ± 10% over old VC versus −46 ± 7% without using apex optimization points). Conclusion: The use of apex optimization points are important in order to avoid significant additional cold doses (−24 ± 2%) at the prescription depth (5 mm) of apex, especially for the new VC applicators that have thicker tops.
Paths to Freedom

A black presence in Portuguese America was the result of an intense slave trade between the ports of Brazil and West Africa for some 300 years. Blacks had been imported into Brazil during the period of the donatories, but it was only with the establishment of the governor-generalship in 1549 and the subsequent development of the sugar plantations that the import of slaves became essential to the Brazilian economy.1 The slave trade has received extensive treatment elsewhere and will only be described here briefly in so far as is necessary to an appreciation of the position of the free black and the free mulatto in the colonial era.2
Racial Disparity In Immunotherapy for Diffuse Large B-Cell Lymphoma Explained by HIV Status In Veterans Administration Patients

Abstract 936 Background- Previous studies have demonstrated that African-American (AA) patients with diffuse large B-cell lymphoma (DLBCL) are less likely to receive rituximab (R) compared to Caucasian patients, despite the incorporation of R into the standard of care in 2002. Reasons for this difference are unclear, though insurance coverage differences have been suggested as one potential cause. We evaluated DLBCL patients treated at Veterans Health Administration (VHA) hospitals in an effort to identify other potential causes of racial differences in R use. Since VHA patients receive treatment regardless of insurance coverage, insurance status should not influence treatment decisions in this population. Methods- Electronic records of patients diagnosed with DLBCL between October 2002 and September 2008 were identified in the Veterans Administration Central Cancer Registry. Data was obtained on patient demographics and stage at diagnosis. Each record was then linked to pharmacy records and ICD-9 diagnostic codes, to identify drugs used in treatment of DLBCL and concurrent co-morbidities respectively. Of 2,164 newly diagnosed DLBCL patients identified in the VACCR, drug records were obtained for 1,942 (90%), and CHOP or R-CHOP was used as first treatment in 1446 (67%). Only patients who received CHOP or R-CHOP were included in the analysis. Demographic and stage variables were reported in approximately 95% of patients. Results- For comparison between AA and Caucasian patients, see Table. Univariate analyses demonstrated significant differences in R use based on age (p =0.002), race (p= 0.006), and HIV status (p Conclusions- After controlling for HIV status, race no longer predicted use of R in patients treated within the VHA system. The decreased use of R in HIV+ patients is likely a related in part to a 2005 publication which demonstrated increased infectious toxicity in HIV associated lymphoma patients treated with R. Given the higher prevalence of HIV in the AA population compared to the Caucasian population in the United States (546.7/100,000 vs. 80.4/100,000 in 2007), differential rates of HIV may be responsible for some of the previously observed disparity in R use outside the VHA. On the other hand, race based differences in age at diagnosis are only partially explained by HIV status. In conclusion, HIV status is an important co-morbid factor that should be considered in future studies of racial disparities in lymphoma patients. Disclosures: Carson: Genentech, Inc.: Consultancy, Speakers Bureau; American Cancer Society, IRG 58-010-52: Research Funding.
Morphomechanics of dermis-A method for non-destructive testing of collagenous tissues

Background Collagenous tissues store, transmit and dissipate elastic energy during mechanical deformation. In skin, mechanical energy is stored during loading and then is dissipated, which protects skin from mechanical failure. Thus, energy storage (elastic properties) and dissipation (viscous properties) are important characteristics of extracellular matrices (ECMs) that support the cyclic loading of ECMs without tissue failure. Methods Uniaxial stress-strain measurements on decellularized human dermis have been made and compared to results of a non-destructive technique involving optical coherence tomography (OCT) combined with vibrational analysis. In addition, Poisson's ratio has been determined for tensile deformation of decellularized dermis. Results The modulus of decellularized dermis measured using standard tensile stress-strain tests and that determined from calculations derived from natural frequency measurements give similar results. It is also observed that Poisson's ratio for dermis is between 0.38 and 0.63 after correction for changes in volume that occur during tensile deformation. These results suggest that the assumption that dermis and other ECMs deform at constant volume is incorrect and will lead to differences in the calculated modulus by conventional tensile stress-strain measurements. Conclusions It is proposed that OCT in conjunction with vibrational analysis is a convenient way to non-destructively measure the modulus of decellularized dermis, ECMs and other materials that have a positive curvature to their stress-strain curves. Tensile deformation of dermis and possibly other ECMs is associated with an increase in Poisson's ratio consistent with a model of fluid expulsion from collagen fibrils during stretching. The value of Poisson's ratio should be considered in analyzing the mechanical properties of ECMs since at least dermis appears to be compressible during tensile deformation. Fluid expression during tensile deformation may play a role in mechanotransduction in skin in a similar manner to cartilage and bone tissue.
Directed Science, Curiosity-Driven Science, and Striking the Balance

After nearly three months as president and one year as president-elect, what amazes me most about the ASM is the breadth and depth of our activities. We literally span the globe, with ambassadors in 54 countries and outreach programs in Africa, South America, and Asia focused on building laboratory capacity for tuberculosis, HIV, and other infectious diseases. The 14 journals we publish are reinventing themselves to remain vital in an electronic world, and mBio, our newly launched premier publication, scored an impressive impact factor of 5.3 less than two years after publishing its first issue. Our membership numbers are up nearly 2% from last year, with the largest increases in student and international members, and a new tiered structure will make it easier and more attractive to join. The General Meeting has recently undergone a metamorphosis, and I am pleased to report that total registration for 2012 was the highest since 2008, with over 9,300 attendees. The Academy of Microbiology continues to examine ways that microbes can positively impact environmental and human health, as exemplified by their recent colloquium on Designing Drugs That Last, and our Public and Scientific Affairs Board has been working tirelessly to advocate on our behalf to agencies and lawmakers throughout Washington. Their current efforts to lobby against across-the-board cuts in discretionary spending, as stipulated in the Budget Control Act of 2011 and slated to be enacted on January 2, 2013, are critical for preventing a potentially crippling blow to the nation’s scientific research enterprise. This is just a small sampling of recent accomplishments and activities, and for more information please see our website at www.ASM.org. It is intended to illustrate the influence and reach of the ASM and its potential for advancing our field, which brings me to the point of this editorial.
Complementary techniques: preparations of entomopathogens and diseased specimens for more detailed study using microscopy

Microscopy techniques and protocols for entomopathogens are varied and often complex with some developed for specific pathogen groups while others can be used regardless of the pathogen or host. This chapter provides the researcher with some of the basic techniques and protocols used to study insect pathogens with light and electron microscopes. Many of the specialized protocols have been developed in order to determine distinguishing characteristics of the pathogen that are often required for proper taxonomic placement. This information is also useful for collecting accurate information on the developmental cycles and host–pathogen relationships of the organisms under study. Specific methods, protocols, and procedures are described and suggestions on possible modifications and adaptations of the standard procedures that are often required depending on the pathogen and host.
Magnesium Development as a Lightweight Material—In Competition with Other Structural Materials

Magnesium is emerging as a lightweight material for mass reduction and structural efficiency in the automotive, aerospace and consumer industries, but is currently only a niche material competing with other structural materials such as advanced high-strength steels, aluminum and carbon-fiber-reinforced polymers. This talk will discuss what the magnesium community can learn from our competition, what critical technologies needed for magnesium to become a main stream material for automotive lightweighting. This talk will also present successful examples of multi-material lightweighting in the automotive industry, and highlight the role of magnesium in providing lightweight solutions when competing with other structural materials. Opportunities and challenges for automotive applications of magnesium will be discussed.
In silico imaging clinical trials for regulatory evaluation: initial considerations for VICTRE, a demonstration study

Expensive and lengthy clinical trials can delay regulatory evaluation and add significant burden that stifles innovation affecting patient access to novel, high-quality imaging technologies. In silico imaging holds promise for evaluating the safety and effectiveness of imaging technologies with much less burden than clinical trials. We define in silico imaging as a computer simulation of an entire imaging system (including source, object, task, and observer components) used for research, development, optimization, technology assessment, and regulatory evaluation of new technology. In this work we describe VICTRE (our study of virtual imaging clinical trials for regulatory evaluation) and the considerations for building an entire imaging pipeline in silico including device (physics), patient (anatomy, disease), and image interpretation models for regulatory evaluation using open-source tools.
Model and analysis of population density estimation via quorum sensing

Microbial communities regulate various collective functions using molecular signaling circuits known as quorum sensing. Understanding and modeling of quorum sensing regulation is essential to design nano-networks and enable communication and coordination among nano-machines. In this paper, a stochastic queuing model of quorum sensing is developed, inspired by known biological processes. The dynamics of quorum sensing across the bacterial community are investigated analytically. Necessary conditions for population density estimation via quorum sensing are presented. It is shown that the synthesis rate of autoinducers needs to lie within a certain range of values, in order to establish correlation between the local autoinducer concentration within each cell and population density.
Acquisition of Tacting Using a Speech-Generating Device in Group Learning Environments for Preschoolers with Autism

Skinner (1957) described the tact as the most important verbal operant; however, there remains a disproportionate amount of research evaluating mand training compared to tact training for young children with autism. The current study sought to alleviate some of this disparity by evaluating the effectiveness of the iPad® and application Proloquo2Go™ as a speech-generating device, using a multiple baseline design, on the acquisition of a tact repertoire in three preschool aged children with autism. The procedures employed a time delay with full physical prompts, during a “circle time” routine. During the circle time routine, the classroom teacher would read the lift-the-flap children’s book “Where’s Spot?” and pause for five-seconds upon reaching the targeted animal for each respective student. During this time delay if the student independently selected the picture that corresponded to the animal, evoking the SGD’s digitized output, the teacher provided verbal praise. If the child did not respond or responded incorrectly, a full physical prompt was used to evoke the tact of the animal. Results indicated that all three participants acquired the ability to tact at least one animal at 100% independence, across three consecutive sessions, after an average of four training sessions. This skill was also found to maintain for those two participants for whom maintenance data were taken. These results extend the evidence base on the use of the iPad® and application Proloquo2Go™ as a SGD, as well as, the research based on tacting acquisition.
Identifying therapeutic targets for Alzheimer's disease with big data.

Nilufer Ertekin-Taner is a Professor of Neuroscience and Neurology at the Mayo Clinic, Jacksonville, FL, USA. A neurogeneticist and board-certified behavioral neurologist, she received her medical degree from Hacettepe University Medical School in Ankara, Turkey and her doctorate degree in Molecular Neuroscience from Mayo Graduate School. She completed her residency training in the Department of Neurology at Mayo Clinic in Rochester (MN, USA) and fellowship in Behavioral Neurology at Mayo Clinic in Jacksonville. Her laboratory aims to discover and characterize genetic factors underlying the complex genetics of Alzheimer's disease (AD) and related neurodegenerative conditions. Her earlier work contributed to the establishment of the endophenotype approach in genetic studies of AD and pioneered the use of amyloid β peptide levels as an endophenotype in AD genetic research. Her laboratory currently uses biological traits such as gene expression levels and cognitive scores and leverages combined genome, transcriptome and epigenetic data to uncover genetic risk factors for neurodegenerative conditions. She is the principal investigator of numerous NIH and foundation grants. She leads multiple collaborative projects aimed at gene and pathway discoveries in AD and other neurodegenerative diseases, as a part of the NIH initiatives Accelerating Medicines Partnership AD (AMP-AD) and Molecular Mechanisms of the Vascular Etiology of AD (M2OVE-AD) consortia. She is the Principal Investigator of the Florida Consortium for African-American AD Studies (FCA3DS). As a neurologist in the Memory Disorders Clinic at Mayo Clinic in Jacksonville, Florida, she continues to evaluate and manage patients with AD and other dementias and aspires to improve the quality of care that we provide to our patients and their families.
School psychologists and full-service schools: Partnerships with medical, mental health, and social services.

Schools that offer medical, mental health, and social services are proliferating. Yet school psychologists typically have a minor role in such full-service schools. This article outlines a conceptu...
Recode then LSB-first SAR ADC for Reducing Energy and Bit-cycles

Least Significant Bit-first (LSB-first) algorithm is suitable for low-activity signals as it reduces DAC activity and the number of bit-cycles required per conversion. However, certain code transitions degrade performance by requiring large switching energy and number of bit-cycles even when the code change over previous code is small. This paper addresses it by a new algorithm called Recode then LSB-first (RLSB-first) that reduces the switching energy required for all cases of small code change across the full range of possible previous sample codes. The energy reduction is achieved while maintaining a low number of bit-cycles per conversion.
Theoretical Overview of Chemical Dynamics

Chemical dynamics is the link between the potential energy surface (or surfaces) and physically observable chemical phenomena. The potential surface comes in principle from an ab initio quantum chemistry calculation (within the Born-Oppenheimer approximation) though in practice it is often constructed by some more approximate model, e.g., semiempirical quantum chemistry or totally empirical “force field” models. The purpose of this Overview is to give a brief snapshot of the present state of the methodology and scope of applications in this area. I will concentrate on chemical dynamics in the gas phase, though much of the methodology (and mentality!) of this field has carried over to the study of dynamical processes in condensed phases, gas-surface collision processes, and also dynamics in biomolecular systems. In these latter fields of application there is obviously strong input from and overlap with statistical mechanics.
Onyx embolization of a ruptured anterior inferior cerebellar artery in a neonate

Aneurysmal subarachnoid hemorrhage (SAH) is rare in neonates. The authors present a unique report of a neonate with SAH from anterior inferior cerebellar artery (AICA) aneurysm rupture that was successfully treated with Onyx embolization. This case report demonstrates the utility of Onyx embolization for posterior circulation aneurysms in neonates and the successful management of SAH in this population.
Towards rapid prediction of drug-resistant cancer cell phenotypes: single cell mass spectrometry combined with machine learning

Combined single cell mass spectrometry and machine learning methods is demonstrated for the first time to achieve rapid and reliable prediction of the phenotype of unknown single cells based on their metabolomic profiles, with experimental validation. This approach can be potentially applied towards prediction of drug-resistant phenotypes prior to chemotherapy.
Sample average approximation for the continuous type principal-agent problem

Abstract We develop a method for finding approximate solutions to the continuous agent type principal-agent problem when analytical methods are not available. The solution is calculated by solving a discrete agent type version of the problem using sample average approximation and bootstrapping. We show how a solution to the approximate problem can be used to derive a lower bound and expected upper bound for the optimal objective function, and evaluate the error associated with the approximation. Numerical examples illustrate convergence in the approximate solution to the true solution as the number of samples increases. This works yields a method for obtaining some tractability in continuous type principal-agent problems where solutions were previously unavailable.
Understanding behavioral dynamics of social anxiety among college students through smartphone sensors

Abstract The way people use smartphones provides a window into the relationship between behaviors and mental health. This relationship is of particular significance to individuals with elevated social anxiety, as it helps to reveal when and where their stress increases in relation to social interactions, ultimately leading to more precise treatment delivery and interventions. In this collaboration between engineers and psychologists, we present the first study to use smartphone sensors to examine socially anxious individuals’ fine-grained behaviors around periods in which they engage in some form of social interaction, and how these behaviors differ as a function of location (e.g., at home, at work, or at an unfamiliar location). In a two-week study of 52 college students, we show that there is a significant difference in behaviors for individuals based on social anxiety levels and locations, in that individuals higher (vs. lower) in social anxiety symptoms exhibit more movement (as tracked by the accelerometer) around the time of phone calls, especially in an unfamiliar location (i.e., not home or at work). Finally, we discuss the implications of these findings for developing better interventions for socially anxious individuals.
Impact of Multi-Disciplinary Care and Clinical Coach Coordinators on Participant Satisfaction and Retention in TBI Clinical Trials: A TEAM-TBI Study.

Background Targeted Evaluation Action and Monitoring of Traumatic Brain Injury (TEAM-TBI) is a monitored, multiple interventional research identifying clinical profiles and assigns individualized, evidence-based treatment program. The objective of the current study was to assess overall participant satisfaction of the multi-disciplinary care team and approach. Methods Between 2014 and 2017, 90 participants completed the 4-day TEAM-TBI clinical intake evaluation resulting in individualized treatment recommendations followed by a six-month intervention phase follow-up. Inclusion criteria were: age 18-60, history of chronic TBI (>6 months post-injury) with refractory clinical sequelae at screening (Post-Concussion Symptom Scale [PCSS] score >30). Results A total of 85/90 (94%) participants completed the survey at baseline focusing on intake evaluation and approach; 90% of eligible participants also completed the follow-up time-point. Hundred percent of participants had a mean score of >4 across all questions at the initial time point." Conclusions The multi-disciplinary care approach and individualized treatment plans of the TEAM-TBI study yielded high participant retention and satisfaction scores. The Clinical Coach component of the trial was one of the highest rated aspects of the program and was associated with participant motivation and high retention rates.
Headache due to spontaneous spinal cerebrospinal fluid leak secondary to cerebrospinal fluid-venous fistula: Case series:

ObjectiveCerebrospinal fluid-venous fistula is an uncommon cause of spontaneous spinal cerebrospinal fluid leak (SSCSFL). We aim to describe the clinical presentation, imaging evaluation, treatment...
Non-Liquid Cellular States

The existence of quantum non-liquid states and fracton orders, both gapped and gapless states, challenges our understanding of phases of entangled matter. We generalize Wen's cellular topological states to liquid or non-liquid cellular states. We propose a mechanism to construct more general non-abelian states by gluing gauge-symmetry-breaking vs gauge-symmetry-extension interfaces as extended defects in a cellular network, including defects of higher-symmetries. Our approach also includes the anyonic particle/string condensation and composite string (p-string)/membrane condensations. This also shows gluing the familiar extended topological quantum field theory or conformal field theory data via topology, geometry, and renormalization consistency criteria (via certain modified group cohomology or cobordism theory data) in a tensor network can still guide us to analyze the non-liquid states. (Part of the abelian construction can be understood from the K-matrix Chern-Simons theory approach and coupled-layer-by-junction constructions.) This may also lead us toward a unifying framework for quantum systems of both higher-symmetries and sub-system/sub-dimensional symmetries.
Age and body composition related-effects on the pharmacokinetic disposition of STEALTH liposomal CKD- 602 (S-CKD602) in patients with advanced solid tumors

2528 Background: STEALTH liposomes (SL), which contain lipids conjugated to polyethylene glycol (PEG), prolong the circulation time of a drug in plasma, achieve high and extended drug exposure in tumor, and are eliminated via the reticuloendothelial system (RES). S- CKD602 is a SL formulation of CKD-602, a camptothecin analogue. CKD-602 released from S-CKD602 is eliminated by the kidney. There is significant interpatient variability in the pharmacokinetic (PK) disposition of S-CKD602. Thus, there is a need to identify factors associated with the PK variability. We hypothesize that older patients (pts) have a reduced capacity to eliminate SL agents due to age-related impairment of the RES and that body composition alters the disposition of SL. Methods: PK studies of S-CKD602 were performed in a phase I study of S-CKD602 at 0.1 to 2.5 mg/m2 IV q 21 d in pts with solid tumors. Concentrations of encapsulated (E), released (R), and sum total (E + R) CKD-602 in plasma and CKD-602 in urine were measured by LC-MS...
Hereditary Transthyretin Amyloidosis and Carpal Tunnel Syndrome: Update on Opportunities for Earlier Diagnosis of Amyloidosis (1594)

Objective: To describe the updated time delay between symptoms of carpal tunnel syndrome (CTS) and diagnosis of hereditary transthyretin amyloidosis (hATTR) as well as opportunities for improvement. Background: CTS is common in many genetic mutations of hATTR amyloidosis, with manifestations known to oftentimes greatly precede diagnosis of amyloidosis, in one recent study by an average of 10.4 years (Karam 2019). In addition, there is a high rate of positive Congo Red staining in tenosynovial tissue after release surgeries, in one study 10%, among these 20% ultimately diagnosed with hATTR (Sperry 2018). These statistics are alarming given the missed opportunities for a timely hATTR diagnosis. Design/Methods: A retrospective chart review of all consecutive patients evaluated at a single United States Amyloidosis Center between January 1, 2016 to December 31, 2018 was performed. Variables coded included genetic mutation, symptoms of CTS, timing of symptoms of CTS, past neurophysiological testing for CTS, carpal tunnel release surgeries, staining results and others. Results: Of 92 total patients, 67 (72.8%) had symptoms of CTS (unilateral or bilateral). The average delay between onset of CTS symptoms and hATTR diagnosis was 5.8 years. The respective prevalence of symptoms of CTS among most common mutations was 83% (V30M), 80% (L58H), 75% (T60A) and 64% (V122I). Ninety-five percent of patients who had CTS symptoms without neurophysiological confirmation prior to evaluation at the center were recommended to have neurophysiological studies after neurological evaluation. Twenty-five patients had prior release surgeries without tenosynovial tissue staining. Conclusions: The updated delay of 5.8 years between onset of CTS symptoms and hATTR diagnosis compared to longer delays previously described suggests better awareness of hATTR in the community. Nonetheless, important efforts for earlier diagnoses should be directed towards lower threshold for staining of tenosynovial tissue after release surgeries and earlier confirmatory neurophysiological studies ideally prior to center referral. Disclosure: Dr. Bhadola has nothing to disclose. Dr. Lau has nothing to disclose. Dr. Kaku has nothing to disclose.
Stressed-out gut bacteria are pterin up gut inflammation.

Sub-inhibitory levels of an antibiotic switch on cryptic stress pathways in Escherichia coli that result in the production of immunomodulatory molecules.
A Shell of Thermal X-Ray Emission Surrounding the Young Crab-like Remnant 3C 58

Deep X-ray imaging spectroscopy of the bright pulsar wind nebula 3C 58 confirms the existence of an embedded thermal X-ray shell surrounding the pulsar PSR J0205+6449. Radially resolved spectra obtained with the XMM-Newton telescope are well characterized by a power-law model with the addition of a soft thermal emission component in varying proportions. These fits reproduce the well-studied increase in the spectral index with radius attributed to synchrotron burn off of high energy electrons. Most interestingly, a radially resolved thermal component is shown to map out a shell-like structure ≈6' in diameter. The presence of a strong emission line corresponding to the Ne IX He-like transition requires an overabundance of ~3 × (Ne/Ne☉) in the Raymond-Smith plasma model. The best-fit temperature kT ~ 0.23 keV is essentially independent of radius for the derived column density of NH = (4.2 ± 0.1) × 1021 cm-2. Our result suggests that thermal shells can be obscured in the early evolution of a supernova remnant by nonthermal pulsar wind nebulae emission; the luminosity of the 3C 58 shell is more than an order of magnitude below the upper limit on a similar shell in the Crab Nebula. We find the shell centroid to be offset from the pulsar location. If this neutron star has a velocity similar to that of the Crab pulsar, we derive an age of 3700 yr and a velocity vector aligned with the long axis of the PWN. The shell parameters and pulsar offset add to the accumulating evidence that 3C 58 is not the remnant of the supernova of CE 1181.
Contribution of Gestational Weight Gain on Maternal Glucose Metabolism in Women with GDM and Normal Glucose Tolerance.

Context Efforts to decrease the risk of developing metabolic complications of pregnancy such as gestational diabetes (GDM) through lifestyle intervention (decreasing excessive gestational weight gain (GWG)) during pregnancy have met with limited success. Objective The purpose of this study was to determine the relationship between the longitudinal changes in weight/body composition and insulin sensitivity and response in women with normal glucose tolerance (NGT) and those who developed GDM. Design We conducted a secondary analysis of a prospective cohort developed before conception and again at 34 to 36 weeks gestation. A total of 29 NGT and 17 GDM women were evaluated for longitudinal changes in insulin sensitivity/response using the hyperinsulinemic-euglycemic clamp and an IV-glucose tolerance test. Body composition was estimated using hydrodensitometry. Both absolute change (Δ) and relative change (%Δ) between these 2 time points were calculated. We performed simple and multiple linear regression analysis to assess the relationship between GWG and measures of glucose metabolism, ie, insulin sensitivity and response. Results Based on the primary study design there was no significant difference in clinical characteristics between women with NGT and those developing GDM. Prior to pregnancy, women who developed GDM had lower insulin sensitivity levels (P = 0.01) compared with NGT women. Absolute change and %Δ in insulin sensitivity/insulin response and body weight/body composition were not significantly different between NGT and GDM women. Changes in body weight contributed to only 9% of the Δ in insulin sensitivity both in women developing GDM and NGT women. Conclusions These data suggest that other factors-such as maternal pre-pregnancy insulin sensitivity and placental derived factors affecting insulin sensitivity-rather than maternal GWG account for the changes in glucose metabolism during human pregnancy.
Medical Spanish in US Medical Schools: a National Survey to Examine Existing Programs.

Most medical schools offer medical Spanish education to teach patient-physician communication skills with the growing Spanish-speaking population. Medical Spanish courses that lack basic standards of curricular structure, faculty educators, learner assessment, and institutional credit may increase student confidence without sufficiently improving skills, inadvertently exacerbating communication problems with linguistic minority patients. To conduct a national environmental scan of US medical schools’ medical Spanish educational efforts, examine to what extent existing efforts meet basic standards, and identify next steps in improving the quality of medical Spanish education. Data were collected from March to November 2019 using an IRB-exempt online 6-item primary and 14-item secondary survey. All deans of the Association of American Medical Colleges member US medical schools were invited to complete the primary survey. If a medical Spanish educator or leader was identified, that person was sent the secondary survey. The presence of medical Spanish educational programs and, when present, whether the programs met four basic standards: formal curricular structure, faculty educator, learner assessment, and course credit. Seventy-nine percent of medical schools (125 out of 158) responded to either or both the primary and/or secondary surveys. Among participating schools, 78% (98/125) of medical schools offered medical Spanish programming; of those, 21% (21/98) met all basic standards. Likelihood of meeting all basic standards did not significantly differ by location, school size, or funding type. Fifty-four percent (53/98) report formal medical Spanish curricula, 69% (68/98) have faculty instructors, 57% (56/98) include post-course assessment, and 31% (30/98) provide course credit. Recommended next steps for medical schools include formalizing medical Spanish courses as electives or required curricula; hiring and/or training faculty educators; incorporating learner assessment; and granting credit for student course completion. Future studies should evaluate implementation strategies to establish best practice recommendations beyond basic standards.
CFD-based study on structured packing geometry

Abstract A computational fluid dynamics (CFD) based investigation of structured packing geometry was performed for gas phase hydrodynamic and mass transfer performance. The computational results were validated with experimental data with a robust mass transfer methodology for the gas-phase resistance identified through pipe flow simulations. The methodology was then applied to structured packing simulations for a variety of industrially relevant geometries. The mass transfer predictions agreed to within five percent of pilot-scale experimental data for standard commercial packings. The geometry of structured packing was studied by systematically changing the specific packing area, channel inclination angle, and channel opening angle to determine the geometry which produced a high degree of mass transfer or a low pressure drop.
Vanadia/Titania Catalysts for Selective Catalytic Reduction (SCR) of Nitric-Oxide by Ammonia: I. Combined Temperature-Programmed in-Situ FTIR and On-line Mass-Spectroscopy Studies

Combined in situ FTIR and on-line mass spectrometric studies have provided simultaneous information of the surface adsorbed species on vanadia/titania catalysts and the composition of reaction products during the selective catalytic reduction (SCR) of NO. The experiments were carried out as temperature programmed surface reaction (TPSR) studies by exposing catalysts with preadsorbed ammonia to either pure NO, pure O2, or a mixture of NO and O2. This allowed detailed information to be obtained concerning the changes in the concentrations and the nature of the surface VO and VOH species. The TPSR studies in O2 showed mainly ammonia desorption and some ammonia oxidation at high temperatures. The SCR reaction was observed to take place during the TPSR studies in both NO and NO + O2, but a greater rate was observed in the latter case. It was found that NH3 reduces the VO species and subsequent reaction with NO results in the formation of reduced VOH species. The results showed that the NO reduction reaction involves the ammonia species adsorbed on VOH Bronsted acid sites. Evidence for the importance of redox reactions was also found. Separate temperature programmed reduction (TPR) studies in H2 showed that the surface vanadia layer breaks up while re-exposing TiOH groups. Subsequent temperature programmed oxidation (TPO) studies in O2 showed this phenomenon to be completely reversible, thus providing direct evidence for spreading/redispersion of vanadia on titania. The TPR/TPO studies also indicated that the Bronsted acid sites essential for the deNOx reaction are associated with V5+OH surface sites.
Inducible knockout of Mef2a, -c, and -d from nestin-expressing stem/progenitor cells and their progeny unexpectedly uncouples neurogenesis and dendritogenesis in vivo

Myocyte enhancer factor (Mef)-2 transcription factors are implicated in activity-dependent neuronal processes during development, but the role of MEF2 in neural stem/progenitor cells (NSPCs) in the adult brain is unknown. We used a transgenic mouse in which Mef2a, -c, and -d were inducibly deleted in adult nestin-expressing NSPCs and their progeny. Recombined cells in the hippocampal granule cell layer were visualized and quantified by yellow fluorescent protein (YFP) expression. In control mice, postmitotic neurons expressed Mef2a, -c, and -d, whereas type 1 stem cells and proliferating progenitors did not. Based on this expression, we hypothesized that Mef2a, -c, and -d deletion in adult nestin-expressing NSPCs and their progeny would result in fewer mature neurons. Control mice revealed an increase in YFP(+) neurons and dendrite formation over time. Contrary to our hypothesis, inducible Mef2 KO mice also displayed an increase in YFP(+) neurons over time-but with significantly stunted dendrites-suggesting an uncoupling of neuron survival and dendritogenesis. We also found non-cell-autonomous effects after Mef2a, -c, and -d deletion. These in vivo findings indicate a surprising functional role for Mef2a, -c, and -d in cell- and non-cell-autonomous control of adult hippocampal neurogenesis that is distinct from its role during development.