cssi/SciSciGPT-SciSciNet huggingface dataset:
Activating Mutations of the FMS-Like Tyrosine Kinase-3 (FLT3) At Complete Response and Relapse in Patients with Acute Myeloid Leukemia,

Abstract Abstract 3557 Background – Activating mutations of the transmembrane receptor tyrosine kinase, FLT3, occur in approximately 30% of patient with acute myeloid leukemia (AML) and predict for a shorter relapse-free and overall survival. There is limited data on loss or persistence of the mutated clones at the time of complete response (CR) and their recurrence at the time of relapse. Objectives and Methods – To evaluate patterns of loss and recurrence of FLT3 mutated clones in relation to response and relapse in patients with FLT3 mutated AML treated with idarubicin and cytarabine (IA) with or without sorafenib (S), vorinostat (V), or tipifarnib (T). Bone marrow samples at diagnosis, CR and relapse were examined for the presence of FLT3 mutated clones using reverse transcription polymerase chain reaction. Results – Among 361 patients with AML treated from October 2004 to March 2010 on one of the 4 induction regimens of IA, IAS, IAV, and IAT, 321 had presentation bone marrow samples tested and 72 had FLT3 mutations (including 50 with ITD and 16 D835 with 6 having both). The median age for the entire group was 53 years (range, 17–73) and for the FLT3 mutated patients 52 years (range, 17 to 73). Cytogenetics at diagnosis in FLT3 mutated patients included normal karyotype in 48 (67%) patients, chromosome 5 and 7 abnormalities in 4(6%), trisomy 8 in 4(6%), 11q abnormalities in 2 (3%), insufficient metaphases in 3(4%), and miscellaneous in 11(16%). 271 (75%) patients overall, and 64 (89%) patients with mutated FLT3 achieved CR. Among the 56 patients with presentation FLT3-ITD, 51 achieved CR. Among 13 patients with available samples at CR, none had FLT3-ITD; 8 of these patients relapsed and 5 had FLT3-ITD positive clones at relapse (2 negative and 1 not done); Among the 38 patients with no samples at CR, 17 relapsed, 8 with a FLT3-ITD clone (1 negative and 8 not done). Among the 201 patients without FLT3-ITD at diagnosis, who achieved CR, 8 patients acquired a clone with FLT3-ITD at relapse. Conclusions – FLT3-ITD mutant clones are unstable at follow-up. Relapse may occur in their absence and they may occur for the first time at relapse. Therefore, FLT3-ITD cannot be used reliably for minimal residual leukemia monitoring. Disclosures: Ravandi: Bayer Onyx: Honoraria, Research Funding.
A hemodynamic-directed approach to pediatric cardiopulmonary resuscitation (HD-CPR) improves survival.

Abstract Aim Most pediatric in-hospital cardiac arrests (IHCAs) occur in ICUs where invasive hemodynamic monitoring is frequently available. Titrating cardiopulmonary resuscitation (CPR) to the hemodynamic response of the individual improves survival in preclinical models of adult cardiac arrest. The objective of this study was to determine if titrating CPR to systolic blood pressure (SBP) and coronary perfusion pressure (CoPP) in a pediatric porcine model of asphyxia-associated ventricular fibrillation (VF) IHCA would improve survival as compared to traditional CPR. Methods After 7min of asphyxia followed by VF, 4-week-old piglets received either hemodynamic-directed CPR (HD-CPR; compression depth titrated to SBP of 90mmHg and vasopressor administration to maintain CoPP ≥20mmHg); or Standard Care (compression depth 1/3 of the anterior–posterior chest diameter and epinephrine every 4min). All animals received CPR for 10min prior to the first defibrillation attempt. CPR was continued for a maximum of 20min. Protocolized intensive care was provided to all surviving animals for 4h. The primary outcome was 4-h survival. Results Survival rate was greater with HD-CPR (12/12) than Standard Care (6/10; p=0.03). CoPP during HD-CPR was higher compared to Standard Care (point estimate +8.1mmHg, CI 95 : 0.5–15.8mmHg; p=0.04). Chest compression depth was lower with HD-CPR than Standard Care (point estimate −14.0mm, CI95: −9.6 to −18.4mm; p Conclusions Hemodynamic-directed CPR improves short-term survival compared to standard depth-targeted CPR in a porcine model of pediatric asphyxia-associated VF IHCA.
Fundamentals Of Multibody Dynamics. Theory And Applications

Preface Particle Dynamics: The Principle fo Newton's Second Law Rigid-Body Kinematics Kinematics for General Multibody Systems Modeling of Forces in Multibody Systems Equations of Motion of Multibody Systems Hamilton-Lagrange and Gibbs-Appel Equations Handling of Constraints in Multibody Systems Dynamics Numerical Stability of Constrained Multibody Systems Linearization and Vibration Analysis of Multibody Systems Dynamics of Multibody Systems with Terminal Flexible Links Dynamic Analysis of Multiple Flexible-Body Systems Modeling of Flexibility Effects Using the Boundary-Element Method Appendix A: Multibody Dynamics Flowchart for the Construction of the Equations of Motion with Constraints Appendix B: Centroid Location and Area Moment of Inertia Appendix C: Center of Gravity and Mass Moment of Inertia of Homogeneous Solids Appendix D: Symbols Description Appendix E: Units and Conversion References Index
Comparison of paleotemperature reconstructions as evidence for the paleo-analog hypothesis

There is an apparent inconsistency between the estimated low accuracy reported by Kheshgi and Lapenis (1996; hereinafter KL) for the reconstructed zonal-mean annual paleotemperatures for the mid-Holocene, and the high agreement reported by Shabalova and Konnen (1995; hereinafter SK) between the normalized temperature anomalies of these reconstructed paleotemperatures and those reconstructed for earlier epochs. The reasons for this inconsistency could be: (i) overestimation by KL of the reconstruction errors by more than a factor of two, (ii) significant smoothing of the paleodata resulting in a reduction in the number of independent pieces of information represented by the zonal-mean temperatures, or (iii) bias of the paleotemperature reconstruction by prior knowledge of the expected patterns of climate change. Because it is unlikely that the errors involved in producing the reconstructed mid-Holocene temperatures have been overestimated by more than a factor of two, one or both of the other reasons is the likely explanation for the inconsistency. If this holds true, then support for the paleo-analog hypothesis provided by the mid-Holocene paleotemperature reconstruction is severely weakened.
Dispositional Influences on Pay Preferences

This study tested whether individual measures of intrinsic and extrinsic motivation and positive and negative affect predict a job seeker's attraction to organizations offering merit pay, skill-based pay, or broad banding. Intrinsic motivation was found to predict a decision for merit pay while extrinsic motivation did not. Hierarchical regression analysis results suggested that job seekers who were intrinsically motivated or experienced positive affect were attracted to pay plans that offer high levels of personal involvement. Individuals who were extrinsically motivated or experienced negative affect were attracted to pay plans that offer higher than average starting salaries.
Complexity Classification of Deterministic Scheduling Problems

Complexity theory is based on a mathematical framework developed by logicians and computer scientists. This theory was developed to study the intrinsic difficulty of algorithmic problems and has proven very useful for combinatorial optimization. This appendix presents a brief overview of this theory and its ramifications for scheduling
Digital Transformation in Alumina Refining

Digital Transformation is a significant enabler for generating business value. Many of these technologies have been used in alumina refining by leading producers and these leaders have realized step changed improvements in operational and business performance. The technologies deployed have included Industrial Internet of things (IIoT), big data, cloud computing, and deep analytics. Other alumina producers are considering these digital technologies to sustain or improve their competitiveness and bottom line. This paper will discuss the value that digital technologies and solutions can deliver to alumina refineries. The author is employed by the leading provider of these technologies and discuss proven technologies and methods used that ensure success of digital transformation to deliver of business value.
Superelectrophilic Activation of Phenylglyoxamides: Efficient Synthesis of Triarylacetamides and Fluorenecarboxamides by Superacid Catalysis

Direct synthesis of triarylacetamides and 9-fluorenecarboxamides has been achieved. Phenylglyoxamides upon superelectrophilic activation in trifluoromethanesulfonic acid (triflic acid, TFSA) leads to Friedel–Crafts hydroxyalkylation or one-pot tandem hydroxyalkylation-4π-electrocyclization of aromatics into triarylacetamides or 9-fluorenecarboxamides, respectively. Mechanistic investigation by DFT calculations suggests the intermediacy of diprotonated (or “protosolvated”) intermediates.
Classification, Evaluation, and Management of Congenital Peripheral Vascular Malformations

The International Society for Study of Vascular Anomalies (ISSVA) categorizes congenital vascular malformations by their flow properties into high-flow arteriovenous malformations, slow-flow venous and lymphatic malformations, and congenital mixed syndromes. Despite historically confusing and often conflicting nomenclature and classification schemes, our understanding of the natural history, hemodynamics, and treatment outcomes of these lesions has expanded and evolved over the last few decades. As such, certain fundamental diagnostic and therapeutic principles have been established and are considered standard of care. It is crucial to adhere to these overarching principles in the overall management of these lesions. These are highlighted and expanded upon in this chapter. Furthermore, recently discovered biomolecular pathways implicated in the pathogenesis of vascular malformations and affiliated syndromes are briefly reviewed.
Studio teaching: An embedded systems course

Teaching microprocessors at the undergraduate level can be accomplished far more effectively when modern teaching techniques utilizing hands-on and project-based methods are implemented. This article presents an embedded systems course taught in a studio format that combines lecturing and laboratory experimentation to teach and train students in the direct application of microprocessor and micro-controller systems. Studio teaching is best conducted in facilities that are designed for that purpose. One of the main topics to be addressed in the development of a studio course is the selection of suitable experiments that seamlessly support effective teaching of fundamental concepts through direct application of those concepts. This paper discusses several aspects of the course development and delivery including facilities, equipment, pedagogy, and example classwork.
CO oxidation catalyzed by Cu-exchanged zeolites: a density functional theory study

The catalytic oxidation of CO by Cu‐exchanged high‐silica zeolites (e.g., ZSM‐5) has been investigated theoretically using density functional theory. Calculations reveal two distinct, parallel pathways for oxidation of CO: (i) adsorption of O2= on a reduced Cu site followed by O atom abstraction by CO, and (ii) adsorption of CO followed by its reaction with O2= to form a cyclic compound which decomposes to form CO2=. The reduced site is regenerated via two different pathways, both of which involve oxidation of one or more CO molecules: (i) abstraction of atomic oxygen by CO from the oxidized active site, and (ii) formation of a carbonate species followed by its reaction with a molecule of CO. The relevance of these reactions to the reduction of NO is discussed.
When is a Computer Program Not a Computer Program - The Perplexing World Created by Proposed U.C.C. Article 2B

The primary purposes of the Uniform Commercial Code set forth in section 1-102(2)(a) are to simplify, clarify, and modernize the law governing commercial transactions. Contrary to this objective, proposed Article 2B of the Uniform Commercial Code adds needless complexity to computer industry transactions. If enacted, it will produce uncertainty in intellectual property transactions, create unnecessary litigation, and eliminate protections for licensees afforded by existing law.
What Is the Problem with Consent Theory

Both defenders and critics of the consent theory of political obligation share a view about the act that expresses consent and grounds political obligations. According to this view, the act of consenting to one's political obligations is no different from the act through which one consents, for example, to return a book to a friend. This view is wrong because it assumes precisely what an answer to the problem of political obligation needs to establish - the existence of shared understandings and reliable expectations about the future. My argument will show that the problem of political obligation is intrinsically related to 'the problem of judgment' - the problem that in the absence of a common judge whose decisions we accept as binding we disagree fundamentally about the meaning of words and we lack relevant shared understandings. These shared understandings are necessary to constitute an act of ours as an act of consent. The problem with the consent theory of political obligation is that it misunderstands the problem of political obligation by de-coupling it from that of judgment and from the question of legitimate authority.
Gating Mechanisms of Shaker Potassium Channels

Voltage-gated ion channels are a class of proteins that change conformation in response to changes in the electrical potential across a cell membrane. By opening and closing in response to changes in membrane potential, they regulate the movement of ions across the cell membrane. The ability of these proteins to change conformation rapidly from closed to open states in response to membrane voltage changes of only a few millivolts suggests a highly sophisticated molecular machinery for sensing membrane voltage and changing conformation. The nature of the gating mechanisms of these molecules has been the object of intensive study by membrane biophysicists over the last forty years (see Hille 1984). From these studies a number of insights about the molecular operation of these channels have emerged. Voltage-dependent gating comes about by a difference in the distribution of charged entities of the channel protein between different conformations. The larger the charge movement parallel to the electrical field across the membrane, between states, the greater the voltage dependence of the transition rate between the states. Many voltage-gated channels inactivate after opening during a step change in voltage by a conformational change that is not very voltage dependent and therefore does not involve a significant movement of charge through the membrane.
Recurrent Malignant Gliomas

Malignant gliomas are the most common brain tumor in adults. Each year, more than 14,000 new cases are diagnosed in the USA. Glioblastomas account for approximately 60–70% of malignant gliomas, anaplastic astrocytomas for 10–15%, and anaplastic oligodendrogliomas, anaplastic oligoastrocytomas, and less common tumors such as anaplastic ependymomas and anaplastic gangliogliomas account for the rest (Primary Brain Tumors in the United States Statistical Report 2007–2008).
Successful Public Health Information System Database Integration Projects: A Qualitative Study

Objective To explore the most important public health information system database integration project success factors, whether technological, organizational, project-specific, or external in nature. Methods This study involved a cross-case design. Cases were identified through literal replication logic and screened through a survey and literature review. Study participants were interviewed through hour-long sessions with a semi-structured guide. Survey responses, interview transcripts and available documents were coded and analyzed deductively, with matrices developed to illustrate relationships. Results Leadership among the project’s participants is the most important integration project success factor. Executive sponsors champion the initiative. Informaticians facilitate communication and system requirement collection. Program directors contribute substantive energy to the project and remove obstacles. Other factors substantially contribute to project success. Strong Financial Management and Support promotes project initiation. Technological aspects impact the functionality of the final product. Utilizing formal project management techniques, particularly the Agile software development methodology, contributes to successful project resolution by ensuring daily operational effectiveness. Discussion The principal finding illustrates project leadership transcending the role of the executive sponsor. Other participants, notably informaticians and program directors, substantially contribute to the project’s success. Additionally, the Agile software development methodology is emerging as a successful approach to project management for these and related projects. Conclusion Investing in the leadership and project management skills of database integration project participants could improve the success of future projects. State health department staff considering these projects should carefully select project participants and train them accordingly.
Mind It: Increasing Rate of Mental Health Disorders in Hospitalized Sickle Cell Patients

Introduction: The number of patients with sickle cell disease (SCD) approaches 100,000 in US after adjusting for early mortality (Hassell Am J Prev Med 2010). Management of SCD and its complications require frequent access to healthcare system lifelong, thus impacting patients9 quality of life and cost of healthcare. Chronic pain inducing illnesses are known to increase susceptibility to mental health disorders (Rayner Pain 2016). Psychosocial disorders are common in this population and impact the course of hospitalization, however we have limited published data in this area. Hence, we performed a large retrospective study utilizing the National Inpatient Sample (NIS) data to evaluate the prevalence of mental health disorders in hospitalized sickle cell patients, and their influence on length of hospitalization. Methods: We identified hospitalized sickle cell patients using ICD 9 codes (282.5,282.6X -282.6X ) in the National Inpatient Sample (NIS) database. Similarly, ICD-9 codes were used to identify patients with mental health disorders of interest. The demographics and length of hospital stay of patients with and without mental health disorders were then compared. Surveyfreq was used to calculate proportions and surveymeans was used to calculate median length of stay and hospital charges. Cochran-Armitage test was used for analyzing trends. We used chi-square for categorical data frequency, P value of Results: We identified a total of 1,349,701 hospitalizations for sickle cell patients between 2003-2014, of which 221,279 (16%) had associated mental health disorders. Mood disorders were most common (40%), followed by substance abuse (28%) and anxiety disorder (16%) (Table 1). Over the timeline of our study, we found a longitudinal trend towards higher prevalence of mental health disorders in hospitalized sickle cell patients (Figure 1). There was higher prevalence of mental health disorders among patients aged between 21-40 years (24%). No difference in the rate of mental health disorders was noted in patients admitted with or without acute sickle cell pain episode. Median length of hospital stay (LOS) was 4 days in patients with mental health disorders (95% CI 4.04-4.12) compared to 3 days in those without (95% CI 3.17-3.20). Conclusion: The prevalence of mental health disorders in hospitalized sickle cell patients has been gradually increasing from 2003 to 2014 and approaches 16% overall. The length of hospital stay is longer for the individuals with these disorders than those without hence, increasing the cost of health care and reducing patient satisfaction. Therefore, early recognition and intervention for mental health disorders is paramount to promote quality of life and reduce health care costs. This demands for a multidisciplinary approach to provide better access to mental health resources to this population in the outpatient setting. Disclosures No relevant conflicts of interest to declare.
Cumulative burden of new-onset chronic health conditions (CHCs) among older cancer survivors.

11528Background: In the US there are an estimated 11 million survivors of cancer diagnosed at ≥65y of age. Description of the morbidity in these survivors has been limited to single complications o...
Abstract 11: Early Magnetic Resonance Imaging to Quantify Ischemic Brain Insult Early Following Cardiac Arrest in a Swine Model

Introduction: Hypoxic ischemic brain injury (HIBI) results from loss of oxygen or perfusion during cardiac arrest and is the most common cause of death/disability in patients surviving to admission...
Sensitivity Analysis of Pore Morphology Method and X-Ray CT Imaging in SWCC Predictions for Ottawa Sand

The hydromechanical response of partially saturated soils at macroscale is a manifestation of fundamental physics associated with pore scale. The Soil Water Characteristic Curve (SWCC) is an important state variable which affects mechanical as well as transport properties in a multiphase porous media. In present work, X-ray CT imaging and Pore Morphology Method (PMM) are leveraged to demonstrate robustness of a predictive approach in enhancing understanding of multiphase flow in sands from a pore scale perspective. The 3D microstructure of the Ottawa sand assembly is obtained from attenuation contrast-based X-ray Computed Tomography (CT) which serves as an input to PMM-based predictions. PMM relies on Young Laplace equation and mathematical morphology to simulate drainage and imbibition processes on an actual pore space. This approach is computationally efficient in comparison to computational fluid dynamics approach where highly nonlinear Navier Stokes equation is solved on a computational grid. In addition, the effect of X-ray CT resolution on SWCC predictions for drainage and imbibition is investigated. The effect of the surface roughness on wettability is demonstrated in numerical predictions by varying contact angle of the three-phase system. The spatial distribution of air and water corresponding to different capillary pressures is presented which can be helpful in developing improved multiscale modeling approaches in partially saturated sands.
Electrocardiographic myocardial injury and stroke mortality in the general population.

Abstract Background Recent evidence suggests a link between myocardial infarction and stroke risk, but it is unclear whether such risk exists with electrocardiographic myocardial injury in otherwise healthy individuals. Therefore, we explored the association of myocardial injury with stroke mortality in participants free of cardiovascular disease. Methods This analysis included 6017 participants (58.4 ± 13.4 years, 54.1% women, 50.3% white) from the Third National Health and Nutrition Examination Survey. Cardiac infarction/injury score (CIIS), a weighted scoring system composed of several electrocardiographic waveform components related to myocardial injury and ischemia, was used to define myocardial injury. Stroke mortality was ascertained using the National Death Index during follow-up. Multivariable adjusted Cox proportional hazard analysis was used to examine the association between baseline myocardial injury and risk of stroke mortality. Results Over a median follow-up of 14 years, 152 stroke deaths occurred. Stroke mortality was more common in those with than those without myocardial injury (3.8% vs. 2.1%, respectively; p = 0.0003). In a model adjusted for potential confounders, the myocardial injury was associated with a 44% increased risk of stroke mortality (HR (95%CI):1.44(1.02–2.03)). In a similar model, each 1 CIIS score point increase was associated with a 2% increase in the risk of stroke mortality (HR (95%CI):1.02 (1.00–1.04), p = 0.01). Conclusions Electrocardiographic myocardial injury in cardiovascular disease-free adults is associated with an increased risk of stroke mortality suggesting a potential link between asymptomatic myocardial injury and risk of cardiac thromboembolism. Whether screening and management of myocardial injury would reduce such risk requires further investigation.
Centre of pressure velocity shows impairments in NCAA Division I athletes six months post-concussion during standing balance

Sport-related concussion return to play (RTP) decisions are largely based on the resolution of self-reported symptoms and neurocognitive function. Some evaluators also incorporate balance; however,...
Midpoints, endpoints and the cognitive structure of events

Events unfold over time, i.e. they have a beginning and endpoint. Previous studies have illustrated the importance of endpoints for event perception and memory. However, this work has only discusse...
A Path Twice Traveled: My Journey as A Historian of China: Paul A. Cohen, Cambridge: Massachusetts: Fairbank Center for Chinese Studies at Harvard University, 2019, 303pp, xii, $33.00 (paperback). isbn: 978-0-674-23729-2

Paul A. Cohen is a well-known American historian who has exerted a wide-ranging impact upon American academic circles. His significant contributions to Chinese studies earn himself a unique fame, a...
Band Gap and Band Offset of Ga 2 O 3 and (Al x Ga 1 -x ) 2 O 3 Alloys

The band gaps and band offsets of the transparent conducting oxides Ga${}_{2}$O${}_{3}$ and (Al${}_{x}$Ga${}_{1\ensuremath{-}x}$)${}_{2}$O${}_{3}$ are key parameters in the design of next-generation high-power transistors and solar-blind ultraviolet photodetectors and solar cells. Based on first-principles calculations, the authors determine the mixing enthalpies, band-gap bowing, and band offsets of (Al${}_{x}$Ga${}_{1\ensuremath{-}x}$)${}_{2}$O${}_{3}$ alloys. The band gap can be tuned across a wide range by changing Al composition, adding great flexibility in device design, while the offset arises mostly from discontinuity in the conduction band.
Locke v. Davey and the Lose-Lose Scenario: What Davey Could Have Said, but Didn't

This Article is brought to you for free and open access by Digital Commons at Michigan State University College of Law. It has been accepted forinclusion in Faculty Publications by an authorized administrator of Digital Commons at Michigan State University College of Law. For moreinformation, please contactdomannbr@law.msu.edu.
A Comparison of Methylprednisolone and Dexamethasone in Intensive Care Patients with COVID-19

OBJECTIVESThis study retrospectively compares the effectiveness of methylprednisolone to dexamethasone in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) requiring ICU care. DESIGNThis is an institutional review board approved cohort study in patients with COVID-19 requiring intensive care unit admission. Patients admitted and requiring oxygen supplementation were treated with either methylprednisolone or dexamethasone. SETTINGThis study takes place in the intensive care units at a large, tertiary, public teaching hospital serving a primarily low-income community in urban Los Angeles. PATIENTSAll eligible patients admitted to the intensive care unit for COVID-19 respiratory failure from March 1 to July 31, 2020 were included in this study. INTERVENTIONSA total of 262 patients were grouped as receiving usual care (n=75), methylprednisolone dosed at least at 1mg/kg/day for [≥] 3 days (n=104), or dexamethasone dosed at least at 6 mg for [≥] 7 days (n=83). MEASUREMENTS and MAIN RESULTSAll-cause mortality within 50 days of initial corticosteroid treatment as compared to usual care was calculated. The mortality effect was then stratified based on levels of respiratory support received by the patient. In this cohort of 262 patients with severe COVID-19, all-cause mortalities in the usual care, methylprednisolone, and dexamethasone groups were 41.3%, 16.4% and 26.5% at 50 days (p <0.01) respectively. In patients requiring mechanical ventilation, mortality was 42% lower in the methylprednisolone group than in the dexamethasone group (hazard ratio 0.48, 95% CI: 0.235-0.956, p=0.0385). CONCLUSIONSIn COVID-19 patients requiring mechanical ventilation, sufficiently dosed methylprednisolone can lead to a further decreased mortality as compared to dexamethasone.
Dynamic distortion of the orientation representational space after learning in the mouse primary visual cortex

Learning is an essential cognitive mechanism that supports behavioral adaptation through neural processing adjustments. Learning was shown to modify sensory integration, yet the nature of those modifications and the computational advantages they confer remain unclear. By comparing the responses of primary visual cortex (V1) neurons evoked by oriented stimuli in naive mice and mice performing an orientation discrimination task, we found that the representations of rewarded and non-rewarded cues were sparser, more accurate and more stable in trained mice. This improved representation was associated with a distortion of the V1 orientation space such that stimuli close to the task cues were represented as the task stimuli themselves. This distortion was context-dependent, as it was absent in trained mice passively viewing the cues. Hence, visual processing in V1 was dynamically adapted to enhance the reliability of the representation of the learned cues and favor stimulus generalization in the task-relevant computational space.
A Content Analysis of How Labels Help Consumers Determine if Clothing is Sustainable

Most articles of clothing regardless of brand name, share similarity of having a label exempting those not regulated by law. The FTC regulates the labelling of clothing in the United States with guidelines and procedures on what must be provided in a label and other hangtags to deter false advertisement and fraud. Clothing labels usually sit on the inside of the neck or side seam of shirts or the back of pants and provide consumers with information such as size, content, and country of origin. Disregarding the brand name of the garment the consumer chooses, clothing labels are the only transcript that provide the consumer with some clue as to what they are wearing. This study explored whether the information presented for consumers is adequate or misleading for consumers to make conscious decisions. A content analysis with substantive coding to analyze the information listed on clothing product labels and how the information is presented from stores as well as online data collection in addition to promotional messages and descriptions. My sample study will include brands identified by Business Insider as the United States most popular as well as brands that have made Eco- Friendly claims. Both online product details and the hand labels will be collected and coded into an excel spreadsheet that will categorize and examine the perception of the garment. A Q- Sort methodology will then be implemented with the findings of the data analysis and will analyze participants viewpoints of the labels. Findings include the misinterpretation of eco-friendly or sustainable product description.
Volunteer and staff participants in social movements: a comparison of two local coalitions

This paper examines how volunteer and staff participants influence coalition functioning and outcomes. We compare two environmental coalitions in Pittsburgh, Pennsylvania: the Clean Rivers Campaign...
“You can be anything [?]” – „Du kannst sein, was Du willst [?]“: Der Geschlechterrollenwandel im Barbie-Werbespot und seine mediendidaktischen Einsatzmöglichkeiten

The article deals with Barbie commercials from the 1980s to the present and examines the role of gender in them. The chapter shows how its concepts seem to change by establishing young transgender models and introducing ideas of female emancipation connected with the American Dream. Despite this transformation the article shows that there are still continuities concerning binary gender concepts. The medial strategies used for the representation of gender in the commercials are analysed and explained in the chapter. At the end, teaching ideas offer possibilities for analysing the spots in primary and secondary school classes.
Bicycle handlebar injuries – a systematic review of pediatric chest and abdominal injuries

Abstract Objective The severity of handlebar injuries can be overlooked due to subtle signs and wide range of associated internal injuries. Our objective was to describe thoracoabdominal injuries due to bicycle handlebars and their outcomes in children. Methods Articles that reported thoracoabdominal injuries were identified from database conception to March 3, 2019 using PubMed, EMBASE, Cochrane Library, CINHAHL Complete, Web of Science and Scopus. A systematic review of studies of thoracoabdominal handlebar injuries in children ≤21 years on human-powered bicycles in English was performed. Information on demographics, clinical features, injuries, interventions and outcomes was noted. Results A total of 138 articles were identified from 1952 to 2019. There were 1072 children (males, 85.1%) and 1255 thoracoabdominal injuries. Mean age was 9.7 ± 3.3 years old. Common clinical features included abdominal pain and guarding, vomiting, fever and a handlebar imprint. The liver was the most frequently injured organ. Surgery was performed in 338 children with a mean age of 10.0 ± 3.3 years. Twenty-seven children (2.5%) were discharged and returned due to worsening symptoms, of whom 23 (85.2%) required surgery. Thirty-one children (2.9%) transferred to a higher level of care due to injury severity. Two deaths were reported. Conclusion Bicycle handlebars can cause significant thoracoabdominal injuries. Presence of abdominal pain, vomiting, fever or a circular imprint on the chest or abdomen should prompt further workup. Future studies on diagnostic modalities and best practices are needed to lower the chance of missed injuries.
WE-G-304-00: It Can’t Happen to Me! - My Position Has Been Terminated, Now What?

In the past few years, several high-profile medical physicists found their positions terminated. It is a fact that no medical physics job is a sinecure, and that individuals can be terminated through no fault of their own. Medical physicists need to be prepared for such an occurrence. Termination provisions in an employment contract, whether individually negotiated or as part of an employee manual, are important, and also generally overlooked when one is going into a new job. Coupled with the fact that most states are “at-will,” that makes for a tough position for any physicist who finds his/her position terminated. In this course, a medical physicist who is also a practicing attorney will start the discussion with a description of the various types of employment situations and employment agreements. This will be followed by two high-profile medical physicists who had their positions terminated in recent years, who will describe their experiences, including answering such questions as How much time were you given before termination was effective? Did you have any foreshadowing of what was coming? How did you deal with the termination? Given hindsight, what would you have done differently to mitigate the effects of your termination? During job interviews, are there ways to open closets to find the skeletons? What advice would you give medical physicists if faced with a similar situation? What can you negotiate in a termination agreement? What kinds of termination agreements could be presented? The symposium will conclude with a panel discussion. Learning Objectives: 1. Identify the various types of employment contracts with an emphasis on termination provisions. 2. Recognize the implications of non-compete clauses in employment contracts. 3. Recognize the possibility of termination of employment. 4. Identify ways to recognize possibly poor employment situations 5. Identify steps that one could take to mitigate the effects of termination.
Economic Epidemiology & Infectious Diseases

Infectious disease is currently the main cause of mortality in the world and has been even more important historically. This paper reviews recent research in economic epidemiology. Specifically, it discusses the occurrence of infectious diseases and the effects of public health interventions designed to control them. Several key points include: differences in the predictions regarding short- and long-run disease occurrence between rational and epidemiological epidemics, the nonstandard effects of interventions when epidemics are rational, the desirability and possibility of eradicating infectious diseases, as well as the components of the welfare loss induced by infectious diseases.
Mathematical models in the design and development of chemical reactors

An account is given of some typical mathematical models used for heterogeneous catalytic reactors. Three aspects of reactor analysis are discussed in particular: formal equivalence between reactors of different type, global analysis corresponding to the study of a set of operating and design conditions, and local analysis which is related to perturbation theory. Es wird eine Darstellung einiger typischer mathematischer Modelle gegeben, die fur heterogen-katalytische Reaktoren verwendet werden. Dabei werden besonders drei Aspekte der Reaktoranalyse diskutiert: die formale Aquivalenz zwischen Reaktoren verschiedenen Typs, die globale Analyse, die der Untersuchung eines Satzes von Betriebs- und Konstruktionsbedingungen entspricht, und die lokale Analyse, die mit der Storungstheorie verknupft ist.
The Essential Child: Origins of Essentialism in Everyday Thought

PART I: THE PHENOMENA PART II: MECHANISMS OF ACQUISITION PART III: IMPLICATIONS AND SPECULATIONS
Academic health sciences librarians' use of the Brandon-Hill selected list in book selection activities: results of a preliminary descriptive study.

Cet article presente une etude mise en place pour evaluer l'utilisation de la liste Brandon-Hill pour la selection de documents et le developpement des collections par les bibliothecaires des bibliotheques universitaires specialisees en sciences medicales aux Etats-Unis et au Canada. Apres une presentation de l'enquete, les resultats sont discutes
A couple analysis of relationship perception among couples who face work demands

This study addresses how couples experiencing work travel demands talk about their relationship. Using a sample of 29 couples who experience work travel, this study examines what couples in separate interviews reported regarding their relationship, and uses mixed-method strategies to develop a typology of couples. Three different relationship types were uncovered: aware couples who consider a variety of aspects of themselves, their partners, their relationships, and their contexts as they discuss their lives; individually focused couples who discuss their relationship only in terms of themselves and their partners; and isolated couples who discuss their relationships void of context. These findings support the notion that couples have a degree of similarity when it comes to social cognitions of their relationships.
Prácticas de enseñanza y enfoques de aprendizaje empleados por los estudiantes en algunos programas académicos de la Institución Universitaria de Envigado. Practices of teaching and the learning approaches of students in some academic programs of UIE.

Practices of teaching and the learning approaches of students in some academic programs of the University Institution of Envigado. Resumen El articulo presenta resultados de la investigacion orientada a indagar por las caracteristicas de las practicas de ensenanza de los docentes universitarios y los enfoques de aprendizaje que emplean los estudiantes universitarios en programas academicos de psicologia, administracion, ingenierias (de sistemas y electronica) y derecho de la Institucion Universitaria de Envigado. La metodologia del presente estudio fue de enfoque cuantitativo y nivel descriptivo. La poblacion del estudio representaron los estudiantes de los programas escogidos. Segun datos obtenidos solo hay una categoria de las practicas de ensenanza que obtuvo puntajes altos: planificacion, lo cual significa que solo en esta categoria se fomenta adecuadamente el aprendizaje profundo en todos los programas. En el resto de las categorias como ambiente en el aula, estrategias de mediacion cognitiva y motivacionales, estrategias evaluativas y recursos didacticos el puntaje medio muestra la necesidad de mejoras significativas. En relacion a los enfoques de aprendizaje se revelo que los estudiantes emplean predominantemente el enfoque superficial de aprendizaje, solo se observa una mayor tendencia hacia el enfoque profundo en los estudiantes de ingenierias, ya que muestran mayores niveles de manejo de estrategias cognitivas y metacognitivas. Palabras clave: practicas de ensenanza, enfoques de aprendizaje, teorias implicitas, Abstract The paper presents results of research aimed to investigate the characteristics of teaching practices of university teachers and learning approaches used by university students in academic programs in psychology, management, engineering (electronics and systems) and right Institution University of Envigado. The methodology of this study was descriptive quantitative approach and level. The study population represented students in selected programs. According to data obtained there is only one category of teaching practices that got high scores planning, which means that only in this category adequately developing deep learning in all programs. In the other categories such as classroom environment, cognitive strategies and motivational mediation, assessment strategies and teaching resources mean score shows the need for significant improvements. Regarding learning approaches revealed that students use predominantly surface learning approach, only there is a greater tendency to focus on the students of engineering, as they show higher levels of management of cognitive and metacognitive strategies. Key words: teaching practice, learning approaches, implicit conceptions.
Motivations and roles for sub–national governmental participation in managing climate change

States and regions provide flexibility and innovation in managing climate change. This is exemplified by energy conservation, transportation, forestry, land use, regional planning, waste management policies and programmes to promote lifestyle changes. Problematically, however, sub–national government roles vary considerably among countries, depending on the division of authority between central government and regions. For example, in federal systems such as the USA, states can serve as policy 'laboratories'. This may be less true in unitary systems. We explore sources of this variation and its significance for understanding sub–national climate change activities.
The octavolateral systems in the stingray, Dasyatis sabina. I. Primary projections of the octaval and lateral line nerves.

The central projections of the electrosensory, mechanosensory, and octaval nerves of the Atlantic stingray were examined by transganglionic transport of horseradish peroxidase. Particular attention was paid to the relation of the projections to cell plates C1 and C2, and to a newly described cell plate, C3. The electroreceptors in the stingray are found in three groups on the dorsal and ventral sides of the body. The electroreceptors are represented topographically on the ipsilateral dorsal nucleus. Those of the rostral part of the head and pectoral fins are represented on the rostroventral part of the nucleus, and those on the caudal part of the head and the pectoral fin on the dorsocaudal part of the nucleus. Mechanosensory lateral line afferents terminate within the ipsilateral intermediate and caudal nuclei, and the lateral granular mass of the vestibulocerebellum. Anterior lateral line afferents also project to the magnocellular octaval nucleus. A topographic representation of the mechanosensory lateral line periphery is present on the intermediate and caudal nuclei. Mechanoreceptors on the trunk are represented laterally and those on the head medially. The terminal field of the anterior lateral line afferents on the intermediate nucleus surrounds cell plates C1 and C2. The anterior lateral line afferents also project to the medial part of the lateral granular mass, whereas the posterior lateral line afferents project to the lateral portion. Sparse projections of anterior lateral line afferents to the periventricular octaval nucleus were also observed. The octaval nerve afferents terminate largely within the octaval column. Octaval nerve projections were also observed to the reticular formation, the periventricular octaval nucleus, the deep cerebellar nucleus, the vestibulocerebellum, particularly the lower lip and medial granular mass, and the intermediate nucleus. A sparse projection to cell plate C3 was found. The relation between cell plates C1 and C2 and the anterior lateral line afferents suggests that these cell plates are related to processing lateral line information. While the relationship between cell plate C3 and the octaval afferents is not strong, the sparse octaval projection C3 receives suggests that it is relaying octaval information. © 1993 Wiley-Liss, Inc.
Role of conduction velocity restitution and short-term memory in the development of action potential duration alternans in isolated rabbit hearts.

Background— Spatially discordant alternans (SDA) has been linked to life-threatening arrhythmias. The mechanisms underlying SDA development in cardiac tissue remain unclear. Methods and Results— We...
Power engineering education: Challenges and opportunities

This paper presents a summary of the presentation given at the IEEE Power Engineering Society 2008 General Meeting in the Panel Session ldquoEducation of the Power Engineer of the Future". In this paper the author presents the challenges facing the current engineering student and the faculty who teach them. Challenges include declining student interest, volatile job markets, and the changing profile of the power and energy industry.
Rinaldo Castello: Berkeley Roots

When asked to write this article about Rinaldo Castello, I found myself reflecting on my own years at UC Berkeley, particularly when I first arrived in the early 1990s. As someone who grew up in Michigan, then attended the University of Michigan for my undergraduate degree, it was certainly a dream of mine to go to graduate school at a place like UC Berkeley. Initially, I was amazed by the faculty, all of them engineering luminaries. I have vivid memories of my first few days on campus, particularly the first time I walked down the corridor of faculty offices on the 5th floor of Cory Hall, awestruck by the names on each door I passed. Every few feet I would say to myself, ?Yep, I used his textbook?.yes, read his book?.oh, I?ve seen several of his papers.? However, after working a few months in Paul Gray?s research group (where, like Rinaldo, I was fortunate to find a place to hang my hat during my first year of graduate school), I soon realized that the uniqueness of Berkeley?s culture and excellence in IC research really lies as much, if not more, with the graduate students as it does with faculty. The leadership, the transfer of technical knowhow, and the breading of a creative environment was really attributed to the students that surrounded us. With every successive generation of graduate students, there always seems to be one student who stands out and leaves a lasting impression. Although Rinaldo was long gone by the time I came to Berkeley, stories of his leadership and technical excellence still abounded; so much so, that before I met him for the first time, I almost had a larger than life image of this person who embodied the ethos of a collaborative research group and had gone on to do so many great things in the IC design community. I met Rinaldo early on during my graduate studies at Berkeley and not only did he live up to the image, but he also became a great friend, from whom I have received so much technical advice and career guidance through the years, as do many former and current EECS graduate students from UC Berkeley.