cssi/SciSciGPT-SciSciNet huggingface dataset:
Signaling Functions of the Tyrosine Residues in the βc Chain of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor

The granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR) is a heterodimeric receptor expressed by myeloid lineage cells. Binding of GM-CSF activates at least one receptor-associated tyrosine kinase, JAK2, and rapidly induces tyrosine phosphorylation of the GMR betac-chain (GMRbeta), but not the GMR alpha-chain (GMRalpha). To examine the role of GMRbeta tyrosine phosphorylaiton, each of the 8 tyrosine residues in the cytoplasmic domain of the human GMRbeta was mutated to phenylalanine (GMRbeta-F8), and this mutant receptor was expressed with wild-type GMRalpha in the interleukin-3-dependent murine hematopoietic cell line, Ba/F3. GM-CSF induced tyrosine phosphorylation of multiple cellular proteins in cells expressing GMRbeta-F8 , including JAK2 and STAT5. However, GM-CSF-induced tyrosine phosphorylation of both SHP2 and SHC was reduced or absent compared with wild-type. Next, a series of 8 receptors were generated, each containing only a single, restored, tyrosine residue. Tyrosine 577 was found to be sufficient to regenerate GM-CSF-dependent phosphorylation of SHC, and any of Y577, Y612, or Y695 was sufficient to regenerate GM-CSF-inducible phosphorylation of SHP2. Despite the signaling defect to SHC and SHP2, Ba/F3 cells expressing GMRbeta-F8 were still able to proliferate in response to 10 ng/mL of human GM-CSF, although mitogenesis was impaired compared with wild-type GMRbeta, and this effect was even more prominent at lower concentrations of GM-CSF (1 ng/mL). Overall, these results indicate that GMRbeta tyrosine residues are not necessary for activation of the JAK/STAT pathway or for proliferation, viability, or adhesion signaling in Ba/F3 cells, although tyrosine residues significantly affect the magnitude of the response. However, specific tyrosine residues are needed for activation of SHC and SHP2.
The 1990 Harry Bruce Legislative Fellowship.

The experiences described here recount my involvement in the various legislative processes and measure the tangible knowledge gained. It is most difficult to convey the impact of these experiences on my values and insights. This of course is not an uncommon phenomenon, it9s encountered daily in dental education. However, probably one of the most significant outcomes of this experience is my expanded appreciation for the role of the AADS Division of Government Affairs in advocating for the concerns of dental education and the betterment of the oral health in our society. They serve and represent us well. However, their success is only as good as the support we, as dental educators, are willing to provide in the legislative process. A major step to the fulfillment of our obligation is simply understanding that we can play a most important role. The next step is informing the AADS of your interest and willingness to support their efforts and becoming a legislative advocate. And finally, when called upon to assist in a legislative effort you must be prepared to respond in a timely manner. I am satisfied that I have fulfilled my goals for the fellowship experience. It is my assessment that the goals of the Association were also met. I have been fortunate to have the opportunity to immediately implement my new knowledge and skills. Since the completion of my fellowship experience I have stayed in touch with the issues and served as a contact person and resource at my institution.(ABSTRACT TRUNCATED AT 250 WORDS)
Limitations of T2*–Gradient Recalled-Echo and Susceptibility-Weighted Imaging in Characterizing Chronic Subdural Hemorrhage in Infant Survivors of Abusive Head Trauma

A possible misconception among radiologists is that chronic subdural hemorrhage should show some degree of blooming on T2*-gradient recalled-echo or susceptibility-weighted sequences such as SWI and susceptibility-weighted angiography, which is not necessarily true. We present 5 cases of chronic subdural hemorrhages in infants, demonstrating intensity near or greater than that of CSF with variable amounts of hemosiderin staining along the neomembranes. We review the physiology and MR imaging physics behind the appearance of a chronic subdural hemorrhage, highlighting that the absence of a BBB can allow hemosiderin to be completely removed from the subdural compartment. Finally, we stress the importance of reviewing all multiplanar sequences for the presence of neomembranes, which can be quite subtle in the absence of hemosiderin staining and are critical for making the diagnosis of chronic subdural hemorrhage.
Rising Syphilis Infection among Rural HIV-Infected Men who Routinely Received Risk-Reduction Counseling: New Challenges to HIV Prevention in Clinical Care

Objective: Syphilis incidence has been steadily increasing among HIV-infected men in the United States, representing an important public health challenge to HIV prevention. Clinic-based HIV prevention interventions are available but may need to be revisited in response to syphilis epidemic. We wanted to better understand the current epidemiology of syphilis in rural HIV-infected men who routinely received HIV risk-reduction counseling in order to plan more effective HIV prevention strategies in clinical care. Methods: We conducted a retrospective cohort study to examine factors associated with syphilis infections in rural HIV-infected men who received sexually transmitted disease screening and HIV risk-reduction counseling during HIV primary care from January 2008 to June 2013. We assessed patients’ demographic, clinical, behavioral and psychosocial characteristics and performed a multivariable exact logistic regression to identify factors related to syphilis. Results: Despite routine risk screening and HIV risk-reduction counseling, a total of 51 syphilis infections were diagnosed among 702 HIV-infected men (5 patients were diagnosed ≥ 2 episodes). The majority of the study participants was sexually active and reported at least one unsafe sexual behavior, mainly inconsistent condom use. Younger age (<35 years, adjusted odds ratio (aOR)=3.09), higher educational attainment (some college or above, aOR=3.72), and perception that the partner may have sex with other people (aOR=3.10) were significantly associated with syphilis infection. Non-injection drug use was related to syphilis in HIV-infected men who have sex with men (aOR=2.86). Discussion: Some HIV-infected men, especially young, educated men, or those who perceived that their partners may have sex with other people, continue to have high-risk behaviors that increase their own risks of acquiring syphilis and may also facilitate HIV transmission. New strategies need to be developed for HIV primary care providers to help HIV-infected patients maintain safer sex practices.
Malfunction Analysis of a 220 kV Transformer

With the fast development of power grids,the malfunction of transformer winding deformation caused by external short circuit increases a lot.According to a practical fault case of a 220 kV transformer,the fault reasons are analyzed in the paper,and the transformer inner winding's ability to withstand short circuit is checked.
Histological changes in the cow following progestogens.

80 heifers 18 to 21 months old were fed 180 mg of progesterone derivative containing medroxyprogesterone acetate daily over an 18-day period. Follicle size was normal in most heifers slaughtered on Days 2 3 4 and 5 after last progesterone feeding (Day 0). Of the 40 heifers slaughtered on Days 4 and 5 70 percent had ovulated and 15 percent showed luteinization of unruptured follicles. The relation of oviduct epithelial cell height to the estrus cycle was normal. On Days 2 3 4 and 5 the authors found 19 20 4 and 0 uteri were vascular. Seperation of the epithelium from the stratum compactum was observed in 13 9 5 and 7 animals on Days 2 3 4 and 5 respectively. The difference between day means of uterine gland epithelial height increasing to Day 4 and decreasing on Day 5 was significant (p less than .01). Cervices of 20 percent of heifers slaughtered on Day 4 were small and hard. Examination of control heifers is necessary for a more definite determination of causes for lowered conception rate at the first synchronized estrus of heifers fed progesteron compounds.
Role of kinins in pain and hyperalgesia: Psychophysical studies in a patient with kininogen deficiency

1. Bradykinin is considered to be an important mediator of pain and hyperalgesia associated with injury and inflammation. Psychophysical studies were conducted in a patient with complete kininogen deficiency to determine whether the absence of bradykinin was associated with abnormalities in pain sensibility. Pain evoked by heat stimuli to the thenar eminence was tested before and after a localized burn, which has been shown to cause hyperalgesia in normal subjects. In addition, pain evoked by intradermal administration of bradykinin (0.1-10 micrograms) to the forearm and the effects of bradykinin on pain induced by heat stimuli were studied. The patient rated the intensity of pain evoked by all heat stimuli relative to the pain induced by a 3 s 45 degrees C stimulus. 2. The patient's heat pain threshold (45 degrees C) in the glabrous skin was similar to that of age-matched control subjects (n = 5) and to that previously observed in younger control subjects. 3. The burn resulted in a decrease in pain threshold and an increase in pain induced by suprathreshold stimuli. The magnitude of hyperalgesia was within the range observed in the age-matched control subjects and in younger control subjects. Thus, kinins are not essential for the development of hyperalgesia after heat injury. 4. In control subjects, intradermal injections of bradykinin produced pain and hyperalgesia to heat stimuli. In the patient, intradermal bradykinin injections induced minimal pain and no hyperalgesia to heat stimuli. Thus, congenital absence of kininogens may be associated with a deficiency in bradykinin receptors.
Recovery of 13CO2 from infused [1-13C]leucine and [1,2-13C2]leucine in healthy humans

Carbon (C) in the 1-position of leucine is released as CO2 with the decarboxylation of α-ketoisocaproate (KIC). Carbon in the 2-position of leucine undergoes several additional metabolic steps befo...
Pseudoachalasia presenting 20 years after Nissen fundoplication: a case report

Background Pseudoachalasia is a rare diagnosis manifested by clinical and physiologic symptoms of achalasia, with alternative etiology for outflow obstruction. While malignancy is a frequent cause of pseudoachalasia, prior surgical intervention especially surgery involving the esophagogastric junction, may result in a misdiagnosis of achalasia.
Ceramics from the Kelley site : Perspectives on the Oneota tradition in southeast Iowa

The Kelley phase is a Middle period Oneota manifestation, dating to the fifteenth century. It is one of three phases comprising a local sequence in the Kingston locality in southeast Iowa. From early to late these are the Burlington, Kelley, and Bailey Farm phases-all defined on the basis of ceramics. Similar ceramic variation occurs coevally with other southeast Iowa localities as well. The defining features of Kelley phase pottery include shoulder motifs composed of alternating or opposed trailed-line-filled triangles or vertical bands of parallel trailed lines in association with strap handles which are either attached to or below the exterior lip-rim juncture. Arguments for replacing the current Oneota horizon model with a descriptive taxonomy based on a temporal model are presented Group continuities and issues ofethnic boundaries and ethnic continuity are examined in the contexts of the present and proposed taxonomic models with respect to the ethnographic record.
Dynamics of Foliage and Thatch Populations of Introduced Pseudomonas fluorescens and Streptomyces sp. on a Fairway Turf

Populations of bacteria (Pseudomonas fluorescens A506 and Streptomyces sp. strain 93) applied to a creeping bentgrass/annual bluegrass fairway turf were followed over time on leaves and thatch. While introduced populations remained at detectable levels over a period of 11–25 days, they usually declined gradually and did not increase after their application to turf. Streptomyces rapidly disappeared from leaves while P. fluorescens was able to maintain similar population sizes on both thatch and leaves, after an initial decline of about 1-log unit, showing that it was actively colonizing the foliage despite loss of biomass from lawn mowing. Throughout these experiments, populations of indigenous microbes on foliage and thatch remained stable, about 106 and 108 cfu g−1 for fungi and bacteria, respectively, and were not affected by the application of bacterial antagonists. Niche-clearing with hydrogen peroxide, which temporarily reduced the population size of indigenous microorganisms two-fold, caused population size of P. fluorescens to increase approximately ten-fold within 24 h, while it declined by about one log unit on untreated turf. It is concluded that the indigenous microflora competes with introduced bacterial antagonists and interferes with their establishment and persistence on turf. Additional studies with P. fluorescens revealed that its population size was inoculum dose-dependent and that solid top dressing was slightly more efficient than spraying liquid suspension in establishing the antagonist. It was possible to maintain P. fluorescens populations above 105 cfu/g of thatch and leaves for 2 weeks or more with both top-dressing or spraying with about 1 to 3 × 1010 cfu m−2.
Teilhard's Vision and the Environment

Pierre Teilhard de Chardin was a pioneer in integrating modern science and Christian theology. He was also a mystic who throughout his life and writings attempted to share the ways in which the divine was the source, power and goal of all creation and to point out how spirit glowed within all of matter. Teilhard's vision of the earth can be most helpful today as we attempt to restore and sustain our environment. In this article I will explore Teilhard's deep reverence for the cosmos and humanity, as well as his views on how God's power works through Christ and the church. Along the way I will suggest how this vision might be linked to our contemporary concerns for our environment. I will close with some recommendations for updating Teilhard's vision so that it might better serve our present day needs.
Who Controls Public Lands?: Mining, Forestry, and Grazing Policies, 1870-1990

In this historical and comparative study, Christopher McGrory Klyza explores why land-management policies in mining, forestry, and grazing have followed different paths and explains why public-lands policy in general has remained virtually static over time. According to Klyza, understanding the different philosophies that gave rise to each policy regime is crucial to reforming public-lands policy in the future. Klyza begins by delineating how prevailing policy philosophies over the course of the last century have shaped each of the three land-use patterns he discusses. In mining, the model was economic liberalism, which mandated privatization of public lands; in forestry, it was technocratic utilitarianism, which called for government ownership and management of land; and in grazing, it was interest-group liberalism, in which private interests determined government policy. Each of these philosophies held sway in the years during which policy for that particular resource was formed, says Klyza, and continues to animate it even today. |With the arrival of European settlers during the seventeenth century, Native American ways of life and the environment itself underwent radical alterations as human relationships to the land and ways of thinking about nature all changed. This colonial ecological revolution lasted until the nineteenth century, when New England's industrial production brought on a capitalist revolution that again remade the ecology, economy, and conceptions of nature in the region. In a preface to the second edition, Merchant introduces new ideas about narrating environmental change based on gender and the dialectics of transformation, while the revised epilogue situates New England in the context of twenty-first-century globalization and climate change.
An analysis of the error in indirect rotor position sensing of switched reluctance motors

It is noted that rotor position information is essential for the operation of the switched reluctance motor (SRM) drive for generating the phase current switching signals. The accuracy of this position information dictates the efficiency and smoothness of the drive. The authors present the results of an accuracy analysis of a novel indirect SRM position sensing scheme, the FM (frequency modulated) encoder. The technique can be used to detect the rotor position with an error of 1 degrees electrical. The analysis breaks down the position error to its fundamental sources in the position sensing system. The same basic approach can be used to evaluate other SRM rotor position sensing schemes. The results are helpful in comparing the various sensing schemes as well as focusing improvement efforts on the right component in the system. >
The Voyage of La Pérouse: Part 2 From Monterey Bay to Botany Bay

The expedition sailed from Monterey Bay on 24 September 1786 meaning to cross the Pacific to reach the Portuguese colony of Macao. By that date, the Spanish enthusiasm for discovery had flagged, and their chief concern had become the security of the route from Acapulco to Manila. Whereas the French, primarily interested in new discoveries and the promotion of navigation in little-known areas, chose a more northerly route through waters less explored. The benefits from a leisurely passage for exploration had to compete with a need for repairs to the ships that could not be accomplished until reaching Macao. As a consequence, anchorages during the crossing would be few and brief, a circumstance necessarily irritating to the naturalists on board but beyond their control.
Child-Centered Play Therapy: Nancy from Baldness to Curls.

Nancy stood in the middle of the waitand eat. Nancy's parents had decided ing room, in the midst of a new and she needed counseling. After diagnostic strange environment known as the Pupil interviews with her mother, the coun Appraisal Center, a multidisciplinary seling staff concurred and determined counseling and diagnostic center for that play therapy, accompanied by pe children and families on the North riodic parent interview, would be the most Texas State University campus. The efficient therapeutic procedure, fingers of her left hand made small cir cling movements over her head as if entwining strands of hair, while two RATIONALE FOR USING fingers of her right hand completely PLAY THERAPY filled her mouth. For the most part, Nancy looked like any other 4-year old. , ,. r 7 ,. .7 . , . 7 . "lay is the child s natural medium of 1 here was one distinguishing charac,. ,n.n ... , . 6.. o. expression (Axline, 1947; Ginott, 1961), tenstic though that could not be over, ,. , , , . . , 6 . , , . .. .... and according to Ginott (1961), the play looked. She was completely bald! The r . ... . , , , , . .. _r, r' of a child is talk, with toys as the words, circling movement of thehngersol her , , , i r i ■ • r • . . . . Thus, play is to the child what verbal left hand left little doubt that there once
Caretaker Awareness of Health Care Provided Developmental Screening: Increases from 2007 to 2012.

Objectives Developmental screening is considered critical to identifying children with developmental delays and disabilities so that they may receive early intervention. To date, only a handful of studies report data on the percentage of health care professionals (HCP) who provide developmental screening. These reports are limited by low participation rates and reporters being pediatricians who may be biased towards reporting higher rates of developmental screening. The purpose of this study is to verify reported increases by reporting on changes in caretakers’ awareness of HCP provided developmental screening from 2007/2008 to 2011/2012. Methods Authors report data on caretaker reported receipt of HCP provided developmental screening from the National Survey of Children’s Health (NSCH, 2007/2008) and NSCH (2011/2012), as well as changes from the 2007/2008 to 2011/2012. Changes for the 50 states plus Washington D.C. are visualized using ‘micromapST’ and states are organized in ascending order according to changes in caretaker awareness of developmental screening. Results Nationally, the proportion of caretakers aware that their HCP provided developmental screening increased from 23.0% in 2007/2008 (range 12.6–46%) to 33.3% in 2011/2012 (range 19.4–61.6%) and states level changes ranged from −2 to +35%, with a median change of +10%. Conclusions for Practice Data reported here indicate that a greater number of caretakers are aware that their HCP is providing developmental screening. This reinforces the existing reports indicating increases in HCP reported developmental screening. Despite growth, there is still a need to increase developmental screening efforts in many states.
Polyomaviruses of Humans

Both JC virus (JCV) and BK virus (BKV) were first isolated in 1971 from the brain tissue of a patient suffering from progressive multifocal encephalopathy (PML) and from the urine of a kidney allograft recipient with chronic pyelonephritis respectively. Both viruses are members of the polyomavirus family and are non-enveloped DNA viruses with icosahedral capsids containing a small, circular, double-stranded DNA genome. JCV is the etiologic agent of PML, whereas BKV is involved in polyomavirus-associated nephropathy (PVAN) in patients receiving renal transplants. The genomic organization of both viruses is very similar to that of simian vacuolating virus 40 (SV40) in that regulatory and coding regions make up of the genome of each virus. The regulatory region of each virus consists of the origin of DNA replication and promoter/enhancer elements and is responsible for the regulation of viral early and late gene expression. Both viral genomes are oncogenic in experimental animals and can transform cells in tissue culture system. In addition, both genomes have been detected in a variety of human tumors. Despite the extensive structural and genomic similarities, JCV and BKV display a distinct biology with respect to the infection of the specific tissues in human host. There has been a rapid expansion in the number of the additional human polyomaviruses in recent years, due to new discoveries, bringing the present number to 13. Those include merkel cell carcinoma-associated polyomavirus (MCPyV) and Trichodysplasia Spinulosa-associated polyomavirus (TSPyV) Karolinska Institute polyomavirus (KIPyV), Washington University polyomavirus (WUPyV), human polyomavirus-6 (HPyV6), human polyomavirus-7 (HPyV7), human polyomavirus-9 (HPyV9), human polyomavirus-10 (HPyV10) Malawi human polyomavirus (MWPyV), Mexico X human polyomavirus (MXPyV) and human polyomavirus-12 (HPyV12). Among those recently discovered human polyomaviruses, only MCPyV and TSPyV appear to be associated a human disease; the rest has yet to be definitively linked to with a particular human disease. In this review, a particular attention was devoted to the description of the biology of JCV, BKV, MCPyV and TSPyV.
Evaluation of component repair using direct metal deposition from scanned data

In this work, the repair volume of AISI H13 tool steel samples with hemisphere-shaped defects was reconstructed through reverse engineering and the samples were repaired by laser-aided direct metal deposition (DMD) using Co-based alloys powder as the filler material. Microstructure characterization and elemental distribution of deposits were analyzed using optical microscope (OM), scanning electron microscope (SEM), and energy dispersive spectrometry (EDS). Mechanical properties of repaired samples were evaluated via tensile test and microhardness measurement. The experiment showed that a gap between deposits and substrate exists if only employing the tool path generated from the reconstructed repair volume but the gap can be removed by depositing an extra layer covering that region. Microstructure and tensile test confirmed strong metallurgical bond in the interface. Defect-free columnar structure dominated the deposits near the interface while other regions of deposits consisted of dendrite structure with interdendritic eutectics. The tensile test showed that the repaired samples have a higher ultimate tensile strength (UTS) and lower ductility compared with those of base metal. Fractography from tensile test showed repaired samples fractured brittlely at the deposits section with cracking propagating along the grain boundaries. The hardness measurement showed that the deposited layers have a much higher hardness in comparison to the substrate.
Tumor-Like Reaction to Polypropylene Mesh from a Mid-Urethral Sling Material Resembling Giant Cell Tumor of Vagina.

Background. Polypropylene material is widely used in gynecological surgery. There are few reports regarding its carcinogenic potential. There is lack of evidence supporting tumor formation directly attributed to the use of polypropylene material. Case. This patient is a 49-year-old woman with a history of stress urinary incontinence which required a MiniArc® Sling who presented with a hard, tender, immobile mass on the anterior vaginal wall. Pathological analysis of the mass revealed a tumor-like reaction to the polypropylene material that resembled a giant cell tumor of soft tissue. Conclusion. The use of polypropylene in surgery is ubiquitous across disciplines; thus consideration for a tumor-like reaction to the material should exist for patients who present with a mass near the surgical site.
Time Series Disturbance Detection for Hypothesis-Free Signal Detection in Longitudinal Observational Databases

Signal detection remains a cornerstone activity of pharmacovigilance. Routine quantitative signal detection primarily focuses on screening of spontaneous reports. In striving to enhance quantitative signal detection capability further, other data streams are being considered for their potential contribution as sources of emerging signals, one of which is longitudinal observational databases, including electronic medical record (EMR) and transactional insurance claims databases. Quantitative signal detection on such databases is a nascent field—with published methods being primarily based either on individual metrics, which may not effectively represent the complexity of the longitudinal records and their necessary variation for analysis for drug–outcome pairs, or on visualization discovery approaches leveraging multiple aspects of the records, which are not particularly tractable to high-throughput hypothesis-free signal detection. One extensively tested example of the latter is chronographs. We apply a disturbance detection algorithm to chronographs using UK EMR The Health Improvement Network (THIN) data. The algorithm utilizes autoregressive integrated moving average (ARIMA)-based time series methodology designed to find disturbances that occur outside the normal pattern trends of the ARIMA model for the chronograph. Chronographs currently highlight drug–event pairs as potentially worthy of further clinical assessment, via filter-based increases in disproportionality scores from before to after the index drug exposure, tested across a range of case and control windows. We replicate the findings on six exemplar chronographs from a previous publication, and show how disturbances can be effectively detected across this set of pairs. Further, 692 disturbances were detected in analysis of all 384 individual READ code outcomes ever recorded 50 or more times for patients prescribed sibutramine. The disturbances are algorithmically further broken into subsets of clinical interest. Overall, the disturbance algorithm approach shows promising capacity for detecting outliers, and shows tractability of the algorithmic approach for large-scale screening. The method offers an array of pattern types for detection and clinical review.
Real, Unreal, and Hacked

This installment of Notes from the Community covers emerging virtual, augmented, and mixed reality applications; security and privacy issues related to Internet of Things devices; and talking fish.
Multivariate Analysis of Students Perception on Teaching with Client Based and Non-Client Based Team Projects

The classroom experience has evolved from traditional lecture, PowerPoint and whiteboards to a more active environment where students and instructors work together more on hands-on activities to achieve the course objectives. Various names have been given to this pedagogy; experiential learning, project-based learning, active learning, problem-based learning are a handful of names used to describe this evolving pedagogy. The main challenge faced by educators in educating undergraduate students to be independent thinkers and problem solvers, has been the driving force fueling the shift in pedagogy. The skill sets needed to be successful in the workforce has also evolved over the years. Today’s employees are not only expected to demonstrate proficiency in green skills in their field of study, but must also possess soft skills required to be competitive in the industry. Gone are the days where engineers worked in silos applying their green skills to create for the common good. To be productive, employers expect today’s engineer to demonstrate the ability to work in teams, communicate effectively, while applying the technical and analytical know-how needed to achieve a desired goal. To ensure that undergraduate students have these desired skills, most engineering educators have shifted away from the traditional all lecture classes and are applying active learning pedagogies. This research looks into student’s perception on project-based learning with client based and non-client based projects in terms of: the project as a learning device, contribution to research knowledge, motivation to learn, contribution to skills and personal benefits, and their effects on student evaluation of teaching and motivation to learn.
Real-Time Change Point Detection with Application to Smart Home Time Series Data

Change Point Detection (CPD) is the problem of discovering time points at which the behavior of a time series changes abruptly. In this paper, we present a novel real-time nonparametric change point detection algorithm called SEP, which uses Separation distance as a divergence measure to detect change points in high-dimensional time series. Through experiments on artificial and real-world datasets, we demonstrate the usefulness of the proposed method in comparison with existing methods.
Biochemical Purification of a CSF-1 like Molecule Released during Malignant Transformation of IL-3 Dependent Hematopoietic Progenitor cell lines Cocultivated with Gamma Irradiated Clonal Marrow Stromal cell lines

Cocultivation of IL-3 dependent hematopoietic progenitor cell line FDC-P1JL26 with 5000 cGy irradiated clonal bone marrow stromal cell line D2XRII has been demonstrated to stimulate selection of factor independent hematopoietic cell lines that produce tumors in vivo (1,2). Hematopoietic stem cell specific and stromal cell specific variables in this experiment have been described (3). The precise molecular mechanism of the malignant transformation of hematopoietic cells and the growth factor or cell membrane contact which is responsible for the transformation have not yet been elucidated. Biochemical purification of several liters of conditioned medium from D2XRII cells revealed a 75,000 molecular weight protein that was neutralized by a polyclonal antiserum to M-CSF. This growth factor stimulated formation of macrophage colonies in fresh mouse bone marrow cells in vitro. A biochemical purification scheme utilizing a Pellicon cassette system concentration, followed by lentil lectin chromatography, ion exchange high pressure liquid chromatography, gel filtration high pressure liquid chromatography, and reverse phase HPLC yield biological activity using tritiated thymidine incorporation into microwell cultures of FDC-P1JL26 cells (4). Active fractions were run out on NaDodSO4/PAGE gel electrophoresis and revealed a band consistent in size with 75,000 molecular weight.
State of water in void-free and void-containing epoxy specimens:

AbstractThe effect of voids on the state of water absorbed in epoxy has been examined using differential scanning calorimetric analysis for a range of void contents (0 to 50%). For void-free specim...
cuRipples: influence maximization on multi-GPU systems

Influence maximization is an advanced graph-theoretic operation that aims to identify a set of k most influential nodes in a network. The problem is of immense interest in many network applications (e.g., information spread in a social network, or contagion spread in an infectious disease network). The problem is however computationally expensive, needing several hours of compute time on even modest sized networks. There are numerous challenges to parallelizing influence maximization including its mixed workloads of latency- and throughput-bound steps, frequent and irregular access to graph data, large memory footprint, and potential load imbalanced workloads. In this work, we present the design and development of a new hybrid CPU+GPU parallel influence maximization algorithm (CuRipples) that is also capable of running on multi-GPU systems. Our approach uses techniques for efficiently sharing and scheduling of work between CPU and GPU, and data access and synchronization schemes to efficiently map the different steps of sampling and seed selection on a heterogeneous system. Our experiments on state-of-the-art multi-GPU systems show that our implementation is able to achieve drastic reductions in the time to solution, from hours to under a minute, while also significantly enhancing the approximation quality.
Adversarially regularized autoencoder for hyperspectral image unmixing

Deep autoencoders have recently been applied to blind hyperspectral unmixing task to estimate endmembers and their corresponding abundances simultaneously. The objective of an original autoencoder is to reconstruct an input data matrix unsupervisedly with an encoder network and a decoder network. For the purpose of spectral unmixing, the activations of the final layer of the encoder and the weights of the decoder form abundances and endmember signatures, respectively; constraints, e.g., abundance non-negativity and abundance sum-to-one, can be imposed. In this paper, we present a novel regularization technique for autoencoder-based hyperspectral unmixing. The basic idea is the inclusion of a generative adversarial network (GAN) joint training objective to condition the decoder to generalize to unseen abundance mixtures. In addition to regularizing the endmember weights of the decoder, this approach has the benefit of explicitly modeling the prior distribution of hyperspectral pixels for a given scene as the abundance output of the generator. The benefit of the proposed strategy is evaluated on synthetic and real data sets, demonstrating that it can produce endmember estimates closer to the ground truth.
A unified system for tree- and stand-level predictions

Abstract The unified system developed in this study comprises two components, one to predict survival and the other to predict diameter, both at tree and stand levels. The tree survival model defaults to the stand survival model when tree diameter reaches a certain value. Similarly, the tree diameter growth model defaults to the quadratic mean diameter model when tree diameter is equal to quadratic mean diameter. The annual growth approach was used to accommodate growth intervals of different lengths. Parameters of the unified system can be estimated together (Simultaneous Estimation) or separately in two phases (Sequential Estimation). Also investigated was the Disaggregation method in which tree attributes (survival probabilities and diameters) were adjusted to match outputs from the stand-level models (number of trees and basal area per unit area). Results indicated that, overall, the Disaggregation approach gave a better performance than did the Unadjusted approach. On the other hand, the Sequential Estimation narrowly surpassed the Simultaneous Estimation method (overall rank of 1.00 versus 1.10). Parameters of the unified system should be estimated by use of the Sequential Estimation method because it is a simpler method which involves only a subset of the parameters at each estimation phase.
Sgr A* Polarization: No ADAF, Low Accretion Rate, and Non-Thermal Synchrotron Emission

The recent detection of polarized radiation from Sgr A* requires a non-thermal electron distribution for the emitting plasma. The Faraday rotation measure must be small, placing strong limits on the density and magnetic field strength. We show that these constraints rule out advection-dominated accretion flow models. We construct a simple two-component model which can reproduce both the radio to mm spectrum and the polarization. This model predicts that the polarization should rise to nearly 100% at shorter wavelengths. The first component, possibly a black-hole powered jet, is compact, low density, and self-absorbed near 1 mm with ordered magnetic field, relativistic Alfven speed, and a non-thermal electron distribution. The second component is poorly constrained, but may be a convection-dominated accretion flow with dM/dt~10^-9 M_Sun/yr, in which feedback from accretion onto the black hole suppresses the accretion rate at large radii. The black hole shadow should be detectable with sub-mm VLBI.
Measuring Marginal Crime Concentration: A New Solution to an Old Problem:

Objectives:In his 2014 Sutherland address to the American Society of Criminology, David Weisburd demonstrated that the share of crime that is accounted for by the most crime-ridden street segments ...
Becoming Animal of Philosophy: Pragmatism, Pragrammatology, Speculative Pragmatism

I argue that American pragmatism can be understood as an effort to recuperate a sense of the animality of thought and thus as an example of what Deleuze and Guattari call a “becoming animal” within the field of philosophy. At issue in this becoming animal of pragmatism is the influence of Charles Peirce’s theory of abduction on the history of pragmatism from its origins to its more recent reception within Jacques Derrida’s (pra)grammatology and Brian Massumi’s speculative pragmatism. Predicated on the evolutionary notion that animal instinct is the source of language, thought, and inquiry, Peirce’s theory of creative inference, or “abduction” as he called it, has allowed generations of pragmatists to begin “shaking philosophy’s dust off their feet and following the call of the wild” (James); to recognize in the origin of their thought something like “the movements of a wild creature toward its goal” (Dewey); to define intellectual inquiry as “doing what comes naturally” (Fish), and to pursue such inquiry “without method” (Rorty). Emerging under the ostensible heading of a new “humanism”, pragmatism exceeds what Derrida calls “the anthropological limit” from the very start, relieving humanism of its exclusive claim to logocentrism by reinscribing the question if not the origin of the logos within the animal kingdom. Yet unlike Derrida, whose rejection of biological continuism in the name of difference prevents him from committing fully to the logic of abduction, Massumi is able to rehabilitate Peirce’s theory of abduction as the foundation for his speculative pragmatism as a result of his commitment to a processual ontology that rejects binary oppositions in favor of “disjunctive syntheses” and “zones of indiscernibility.” Article received: April 15, 2020; Article accepted: July 1, 2020; Published online: April 15, 2021; Original scholarly paper How to cite this article : Reynolds, Anthony. "Becoming Animal of Philosophy: Pragmatism, Pragrammatology, Speculative Pragmatism." AM Journal of Art and Media Studies 24 (2021): 95–108. DOI: 10.25038/am.v0i24.424
pp→ππ In a baryon-exchange-potential model☆

Abstract A potential-model approach is applied to the antinucleon -nucleon annihilation into two pions, and tested against recent experimental results on angular distributions, including data with a polarized target. We take into account nucleon and delta exchange in the potential, and use a current N−N optical model to generate the initial-state interaction, the one in the final state being ignored. With two parameters appearing in vertex form factors, the main features of the data can be reproduced up to laboratory momenta of 1 GeV/c. Above this point, however, new dynamical effects appear which are not accounted for by the model.
The lymphatic spread of carcinoma of the cervix and of the body of the uterus; a study of 420 necropsies.

Abstract 1. 1. The necropsy study of 420 cases of carcinoma of the cervix (356 cases) and the corpus uteri (64 cases) is presented with the incidence of lymph node involvement, distant metastases, and the assigned cause of death. 2. 2. Careful dissection and multiple sections of the lymph nodes in twenty-six nontreated and fifteen treated cases of cervical carcinoma emphasize the frequency of early metastasis, the probable impedimentary effect of irradiation, and traces the routes of lymphatic spread. The parametrium was involved in 77 per cent of the nontreated cases and 33 per cent of the treated cases. Distant metastasis occurred in 27 per cent of the nontreated and 53 per cent of the treated cases. 3. 3. In the series of 356 nontreated and treated cases of cervical carcinoma, the probable arresting effect of irradiation is emphasized by the difference in the node group involvement. The incidence of distant metastases varies little in the two groups. 4. 4. The lymphatic spread, from cervical carcinoma, follows a constant course, the parametrium, the nodes of the primary group, and finally the secondary group nodes, before extension beyond the pelvis. 5. 5. Uremia, the end result of ureteral compression, was the assigned cause of death in 58.5 per cent of nontreated cases and 49.3 per cent of the treated cases. Evidence of ureteral obstruction and hydronephrosis was found in 82.8 per cent of the nontreated and 78.6 per cent of the treated cases. 6. 6. The routes of lymphatic spread of endometrial carcinoma are less constant. The three main channels permit involvement of the same node groups as found in cervical carcinoma, or a by-passing of the primary groups with metastases directly to the inguinal nodes or the aortic nodes. 7. 7. Uremia and/or pyelonephritis was the most frequent assigned cause of death in cases with endometrial carcinoma. 8. 8. The disintegrating effects of irradiation does not occur in all of the treated cases, and similar changes, though usually of a lesser degree, are present in the nontreated cases. Histopathological changes are more frequent when there is a history of infection. 9. 9. Histopathological evidence is lacking to support the claim that metastatic nodes may be sterilized by irradiation. The necropsy findings suggest the possibility of this effect. 10. 10. The numerous intercommunicating lymphatic vessels account for the unpredictable sites of metastases.
Event-Related Potentials accompanying Voluntary Movement in Rhesus Monkeys*

Publisher Summary This chapter discusses event-related potentials accompanying voluntary movement in rhesus monkeys. The preparation to make a movement is accompanied by a series of scalp potentials. The potentials that precede the movement are bilaterally asymmetrical and are sensitive to such parameters as the force of the movement and the handedness of the subject. The diagnostic value of these movement-related potentials has also been demonstrated with patient populations characterized by such motor disorders as Parkinsonism. However, certain of these results—such as the presence of large pre-movement slow potentials (SPs) in the hemisphere ipsilateral to the responding limb—are difficult to integrate with the relevant anatomical and physiological data. Whereas SP activity has been shown to be lateralized to a much greater degree in human intracerebral recordings, by its very nature, the use of this technique is limited to subjects with pathological conditions. The problems of working with human subjects may be circumvented through the development of an animal model of the relation among movement-related potentials and normal and abnormal motor activities. Indeed, potentials with similar morphologies have been found in monkeys.
Deoxyribonucleic Acid Synthesis in FV-3-infected Mammalian Cells

Deoxyribonucleic acid (DNA) synthesis and virus growth in frog virus 3 (FV-3)-infected mammalian cells in suspension were examined. The kinetics of thymidine incorporation into DNA was followed by fractionating infected cells. The cell fractionation procedure separated replicating viral DNA from matured virus. Incorporation of isotope into the nuclear fraction was depressed 2 to 3 hr postinfection; this inhibition did not require protein synthesis. About 3 to 4 hr postinfection, there was an increase in thymidine incorporation into both nuclear and cytoplasmic fractions. The nuclear-associating DNA had a guanine plus cytosine (GC) content of 52%; unlike host DNA it was synthesized in the presence of mitomycin C, it could be removed from nuclei by centrifugation through sucrose, and it was susceptible to nuclease digestion. This nuclear-associating DNA appeared to be a precursor of cytoplasmic DNA of infected cells. The formation of the latter DNA class could be selectively inhibited by conditions (infection at 37 C or inhibition of protein synthesis) that permit continued incorporation of thymidine into nuclear-associating DNA. The cytoplasmic DNA class also had a GC content of 52%, was resistant to nuclease degradation, and its sedimentation profile in sucrose gradients corresponded to that of infective virus. Contrary to previous reports, we found that (i) viral DNA synthesis can continue in the absence of concomitant protein synthesis, and (ii) viral DNA synthesis is not abolished at 37 C. The temperature lesion in FV-3 replication appeared to be in the packaging of DNA into the form that appears in the cytoplasmic fraction of disrupted cells.