cssi/SciSciGPT-SciSciNet huggingface dataset:
The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice

Voltage-gated L-type Ca(2+) (Ca(v)1.2) channels in vascular smooth muscle cells are a predominant Ca(2+) influx pathway that mediates arterial tone. Channel biogenesis is accomplished when the pore-forming α(1C) subunit coassembles with regulatory Ca(v)β subunits intracellularly, and the multiprotein Ca(v)1.2 channel complex translocates to the plasma membrane to form functional Ca(2+) channels. We hypothesized that the main Ca(v)β isoform in vascular smooth muscle cells, Ca(v)β3, is required for the upregulation of arterial Ca(v)1.2 channels during the development of hypertension, an event associated with abnormal Ca(2+)-dependent tone. Ca(v)1.2 channel expression and function were compared between second-order mesenteric arteries of C57BL/6 wild-type (WT) and Ca(v)β3(-/-) mice infused with saline (control) or angiotensin II (Ang II) for 2 weeks to induce hypertension. The mesenteric arteries of Ang II-infused WT mice showed increased Ca(v)1.2 channel expression and accentuated Ca(2+)-mediated contractions compared with saline-infused WT mice. In contrast, Ca(v)1.2 channels failed to upregulate in mesenteric arteries of Ang II-infused Ca(v)β3(-/-) mice, and Ca(2+)-dependent reactivity was normal in these arteries. Basal systolic blood pressure was not significantly different between WT and Ca(v)β3(-/-) mice (98 ± 2 and 102 ± 3 mm Hg, respectively), but the Ca(v)β3(-/-) mice showed a blunted pressor response to Ang II infusion. Two weeks after the start of Ang II administration, the systolic blood pressure of Ca(v)β3(-/-) mice averaged 149 ± 4 mm Hg compared with 180 ± 5 mm Hg in WT mice. Thus, the Ca(v)β3 subunit is a critical regulatory protein required to upregulate arterial Ca(v)1.2 channels and fully develop Ang II-dependent hypertension in C57BL/6 mice.
Apolipoprotein E Modulates Establishment of HSV-1 Latency and Survival in a Mouse Ocular Model

Purpose: To evaluate and compare the neuroinvasiveness and neurovirulence after ocular HSV-1 infection in ApoE knockout (ApoE−/−) and control C57BL/6 (ApoE+/+) mice. Methods: Age-matched (14 weeks of age) C57BL/6J (ApoE+/+) female mice and female ApoE knockout (ApoE−/−) mice were inoculated by corneal scarification with HSV-1 strain 17Syn+. Analysis of HSV-1 replication in the mouse cornea was assessed through infectious virus assays of ocular (tear film) swabs at 1 to 5 days postinoculation (PI), slit-lamp examination (SLE) of corneas at PI days 1 to 7, and survival of infected mice. The contribution of apoE to the efficient establishment of latency was measured by real-time PCR quantitation of the latent viral genome in the trigeminal ganglia (TG) of infected mice. Results: These studies showed that HSV-1 strain 17Syn+ replicates efficiently in the eyes, regardless of the host ApoE genotype. Neither the scoring of corneal pathology via SLE nor the infectious virus assay of the tear film resulted in any ...
Consistency Tests for the Declarations of U.S. Fissile-Material Production

In the 1970s and early 1980s, the United States Government released data on the history of its purchases of natural uranium, the amount of separative work done by U.S. uranium enrichment plants, and the fission energy released by U.S. production reactors. These data provided the basis of nongovernmental estimates in the 1980s of U.S. production of plutonium and highly enriched uranium. In 1996 and 2006, the United States published reports on its historical production of plutonium and highly enriched uranium respectively. This article presents a first rough analysis of the two sets of data and finds that they are reasonably consistent.
Replacement behavior following deprivation of a saccharin solution or water

The replacement properties of a need system (water) and an incentive system (saccharin) were compared following a 6-day period of fluid deprivation. While water deprivation was followed by complete replacement of the water deficit, deprivation of a saccharin solution was followed by substantial over-replacement of the water deficit. This result is interpreted as indicating, an increase in the incentive value of the saccharin solution attributable to deprivation.
Covering the n-space by convex bodies and its chromatic number

Rogers [A note on coverings, Matematika 4 (1957) 1-6] proved, for a given closed convex body C in n-dimensional Euclidean space R^n, the existence of a covering for R^n by translates of C with density cnlnn for an absolute constant c. A few years later, Erdos and Rogers [Covering space with convex bodies, Acta Arith. 7 (1962) 281-285] obtained the existence of such a covering having not only low-density cnlnn but also low multiplicity c^'nlnn for an absolute constant c^'. In this paper, we give a simple proof of Erdos and Rogers' theorem using the Lovasz Local Lemma. Furthermore, we apply the result to the chromatic number of the unit-distance graph under @?"p-norm.
A Preliminary Analysis of the Palm Flora of the Solomon Islands

The following observations on representation and relationships of palms in the Solomon Islands (including Bougainville) have been extracted from notes and manuscripts on palms of the region. They are based on literature and limited material (chiefly collections of B.S.I.P., Brass, Kajewski), hence are distinctly preliminary in nature. The list will surely change in time—there are, for example, unindentified species of Physokentia on Santa Isabel, of Rehderophoenix on Guadalcanal, perhaps another , and it seems likely that the number of described genera (see Rehderophoenix , Strongylocaryum below) and species (as in Areca ) may be reduced eventually.
Advanced Metering and Demand Response communication performance in Zigbee based HANs

Using IEEE 802.15.4 and Zigbee for home area networks (HANs) in the Smart Grid is becoming an increasingly prominent topic in the research area. As the standard designed for low data rate and low cost wireless personal area networks, IEEE 802.15.4 is widely employed in the construction of home sensor networks to assist with real-time environment information. For the purposes of Smart Grid the Zigbee Alliance has defined new Smart Energy Profile Protocol that leverages the existing TCP and HTTP protocols. In this paper, we provide an overview of the Smart Grid's Advanced Metering Infrastructure (AMI) and Demand Response (DR) functionalities, and the communication requirement they pose for the new SEP protocol. The discussion is followed by an evaluation of the theoretical performance bounds of the new architecture based on a analytical model. We conclude, by extending the model to account for WiFi interference which is expected to be present in home and office environments.
Latin American women and the search for social justice

A clear and detailed study of Latin American women s history from the late nineteenth century to the present."
A Paradigm Shift in Third Sector Theory and Practice: Refreshing the Wellsprings of Democratic Capacity

For the past quarter-century, the field of voluntary action/nonprofit organization/third sector research has been dominated by a paradigm that focuses on organizations certified as tax exempt by the IRS and subject to an inability to distribute economic assets. This definition has facilitated large-scale empirical research but has dropped from visibility a wide range of important community-based voluntary and nonprofit organizations, including in the United States some 9 million grassroots organizations and a wide range of cooperative and mutual benefit organizations. In recent years, a critical literature has developed that challenges this dominant conception. This perspective has taken form under the leadership of the EMES European Research Network and employs a more expansive conception of the third sector than does the conventional American view. That conception is explored and refined in this article, the argument being that the value of the third sector far exceeds the contributions of tax-certified...
C9ORF72 expansion in a family with bipolar disorder

Objective To investigate the role in bipolar disorder of the C9ORF72 hexanucleotide repeat expansion responsible for frontotemporal lobe dementia and amyotrophic lateral sclerosis. Methods Eighty-nine subjects from a previously described panel of individuals with bipolar disorder ascertained for genetic studies were screened to detect expansion of the C9ORF72 repeat. One two-generation family with bipolar disorder and an expanded repeat was characterized in depth using molecular diagnostics, imaging, histopathology, and neurological and neuropsychological evaluation. Results One proband, with the typical clinical presentation of bipolar disorder, carried an expanded C9ORF72 allele of heterogeneous length between 14 and 20 kilobases (kb) as assessed by Southern blot. The expanded allele was inherited from a parent with atypical, late onset clinical features of bipolar disorder, who subsequently progressed to frontotemporal lobe dementia. The expansion in peripheral blood of the parent ranged from 8.5 to 20 kb. Cultured lymphoblastoid cells from this parent exhibited a homogeneous expansion of only 8.5 kb. Conclusions The disease course in the two generations described here demonstrates that expansion of the C9ORF72 may be associated with a form of bipolar disorder that presents clinically with classic phenomenology and progression to neurodegenerative disease. The frequency in our bipolar disorder cohort was only 1%, indicating that C9ORF72 is not a major contributor to bipolar disorder. DNA from cultured cells may be biased towards shorter repeats and nonrepresentative of the endogenous C9ORF72 expansion.
Fetal ethanol exposure and the developing alveolar macrophage

Excessive consumption of alcohol (EtOH), the 3 leading preventable cause of death in the USA, has been shown to lead to increased incidence and severity of acute respiratory distress syndrome. The increased risk of respiratory infections in alcoholics is believed to be due to alterations in alveolar macrophage (AM) function. Previous studies have shown chronic EtOH ingestion leads to increased oxidant stress, increased TGFb production, increased fibronectin production, and decreased phagocytosis in AMs. Alternative (M2) activation of AMs has also been shown to lead to similar alterations. Classical ‘‘M1’’ by T helper 1 (TH1) cytokines leads to a proinflammatory response that is required for the respiratory burst necessary for phagocytosis. However, M2 is induced by TH2 cytokines leads to increased arginase production, increased arginase activity, and increased proline and polyamine production. These events promote fibroblast proliferation, collagen production and fibrosis within the lung. Our aim was to determine if chronic EtOH treatment leads to alterations in the expression of markers of M2 activation in AMs. To test this hypothesis, NR8383 cells, a rat-derived alveolar macrophage cell line, were treated with 0.08% EtOH, 25mM acetylaldehyde (AA), or IL-13, a know activator of M2 activation, 6 GSH or 6 IL-13 neutralizing antibody for 5 days. The cells were then analyzed for arginase activity and expression, active TGF-b production in cell culture media, and fibronectin production by 3T3 cells, a fibroblast cell line. In NR8383 cells, treatment with EtOH, AA, or IL-13 led to increased arginase activity, increased arginase expression, active TGF-b production, and secretion of factors that promoted fibronectin production in 3T3 cells. Supplementation with GSH or IL-13 neutralizing antibody during the 5 day treatment led to partial normalization of arginase activity, arginase expression, active TGF-b production, and activation of 3T3 cells in fibronectin production. In conclusion, several markers of M2 activation were greatly increased in response to EtOH, AA, and IL-13 treatment and GSH/ IL-13 neutralizing antibody treatment blocked these effects suggesting chronic EtOH treatment leads to M2 activation of AMs and antioxidant treatment can partially prevent that switch.
Rural Parentage and Labor Market Disadvantage in a Sub-Saharan Setting: Sources and Trends

High unemployment in many developing countries is intensifying job competition and raising concern for the employment prospects of vulnerable groups, including children of rural parents. This paper examines the trends and sources in employment disadvantage associated with rural parentage in Cameroon. In documenting the sources of inequality, the study moves beyond a "consensus versus conflict" dichotomy, and instead uses regression decomposition to estimate the relative contributions of both perspectives. It also uses fixed-effects methods to examine the importance of unobserved family influences that have been understudied in previous research. In documenting historical change in rural disadvantage, the study distinguishes between long-term trends and shorter-term economic fluctuations. Findings show that although rural parentage does not create a disadvantage in off-farm employment as a whole, it does so within the formal sector. This disadvantage is predominantly due to rural-urban differences in returns to schooling rather than levels of schooling. Disadvantage in schooling has been declining over time but, interestingly, these gains may stall during prosperous times, as these tend to inordinately benefit urban children.
A DSP-based ramp test for on-chip high-resolution ADC

Ramp test approach is widely used in analog-to-digital converter (ADC) built-in self-test (BIST), which generates linear and slow-slope analog ramp signals intended for histogram-based non-linearity test. The test time can be high for high-resolution ADCs. In this paper, a new DSP-based ramp test approach is presented to address the test time issue. The linear range of signal ramp is divided into two parts and a sum of measured ADC outputs is calculated in each part. Characteristics of ramp signals are derived from the two sums so that timedomain function of the ramp generator can be approximately reconstructed to determine non-linearity error of each ADC measurement. With the obtained testing signal function, non-linearity of each measured code is obtained. A minimal number of samples is required to make sure that quantization errors and the non-linearity of unmeasured code are acceptable. Simulations show that the proposed approach is suitable for quick static test of most on-chip high-resolution ADCs.
The Archaeology of Ancestors: The Saxe/Goldstein Hypothesis Revisited

Since the mid-1980s, debates between competing schools of archaeological interpretation have become more theoretical and abstruse, moving away from confrontations over specific methods of analyzing our data. This article reopens arguments over one of the more controversial propositions of the New Archaeology - Saxe's claim that the emergence of formal cemeteries corresponds to the appearance of agnatic lineages monopolizing vital resources through inheritance. The hypothesis is examined in three ways: through a generalized ethnological model; through specific ethnographic data from Taiwan and Kenya; and through a historical comparison of Athens from 500 to 100 BC and Rome from 200 BC to AD 200. It is argued that all three methods lead to a similar conclusion, that many societies do indeed talk about the dead in the way the Saxe/Goldstein hypothesis maintains, but that in any specific instance the cemetery/property message may well be subverted by other arguments which the buriers are making.
Isolation and characterization of cDNA clones for chicken major histocompatibility complex class II molecules.

Summary The chicken major histocompatibility complex (MHC), the B complex, is being intensively analysed at the DNA level. To further probe the molecular structure of chicken MHC class II genes, cDNA clones coding for chicken MHC class II (B-L) p chain molecules were isolated from an inbred G-B2 Leghorn chicken spleen and liver. Twenty-nine cDNA clones were isolated from the spleen and eight cDNA clones were isolated from the liver. Based on restriction maps, most clones could be clustered into one family of genes. Four cDNA clones were sequenced (S7, S10 and S19 from the spleen and L1, which was identical to S19, from the liver). Complete amino acid sequences of B-Lβ chain molecules were predicted from the nucleotide sequences of the cDNA clones. Although both the nature and the location of the conserved residues were similar in chicken and mammalian sequences, some species-specific differences were found, suggesting that the structures of the B-L molecules of this haplotype are similar, but not identical, to their mammalian counterparts.
PLATCOM: a Platform for Computational Comparative Genomics

Motivation: As more whole genome sequences become available, comparing multiple genomes at the sequence level can provide insight into new biological discovery. However, there are significant challenges for genome comparison. The challenge includes requirement for computational resources owing to the large volume of genome data. More importantly, since the choice of genomes to be compared is entirely subjective, there are too many choices for genome comparison. For these reasons, there is pressing need for bioinformatics systems for comparing multiple genomes where users can choose genomes to be compared freely. Results: PLATCOM (Platform for Computational Comparative Genomics) is an integrated system for the comparative analysis of multiple genomes. The system is built on several public databases and a suite of genome analysis applications are provided as exemplary genome data mining tools over these internal databases. Researchers are able to visually investigate genomic sequence similarities, conserved gene neighborhoods, conserved metabolic pathways and putative gene fusion events among a set of selected multiple genomes. Availability: http://platcom.informatics.indiana.edu/platcom Contact:sunkim2@indiana.edu; kwchoi@indiana.edu
A Biologically Accurate 3D Model of the Locomotion of Caenorhabditis Elegans

The nematode Caenorhabditis Elegans has become an important model organism for many areas of biological research including genetics, development, and neurobiology. It is the first organism to have its genome sequenced, complete cell ontogeny determined, and nervous system mapped. With all of the information that is available on this simple organism, \emph{C. elegans} may also become the first organism to be accurately and completely modeled in silico. In this work we take a step toward this goal by presenting a biologically accurate, 3-dimensional model of C. elegans. This model takes into account many facets of the organism including size, shape, weight distribution, muscle placement, and muscle force. We also explicitly model the environment of the worm to include factors such as contact, friction, inertia, and gravity. We tuned and validated our model using video recordings taken of the worm and show that our model accurately depicts the physics of undulatory locomotion used to forward crawl on an agarose surface. We also present evidence that suggests that the forces applied by the nematode during locomotion are not uniform, but decrease as the wave is propagated from its head to its tail.
Angiotensin II Receptor

The diversity of specific physiological effects elicited by angiotensin II1,2 (ANG II) poses a simple but important question: Are they mediated by a single or multiple type of receptors? While workers on ANG II action expected more than one subtype as suggested by the presence of the dithiothreitolsensitive and -insensitive receptors, exceeding instability of the receptor protein thwarted numerous attempts at obtaining direct evidence for its multiplicity. Thus, the development of the new types of ANG II receptor antagonists,3–5 which turned out to be isoform specific, was the important turning point that provided indirect but important tools to reveal the problem of ANG II receptor properties.
The information capacity of the human motor system in controlling the amplitude of movement.

Information theory has recently been employed to specify more precisely than has hitherto been possible man's capacity in certain sensory, perceptual, and perceptual-motor functions (5, 10, 13, 15, 17, 18). The experiments reported in the present paper extend the theory to the human motor system. The applicability of only the basic concepts, amount of information, noise, channel capacity, and rate of information transmission, will be examined at this time. General familiarity with these concepts as formulated by recent writers (4, 11,20, 22) is assumed. Strictly speaking, we cannot study man's motor system at the behavioral level in isolation from its associated sensory mechanisms. We can only analyze the behavior of the entire receptor-neural-effector system. However, by asking 51 to make rapid and uniform responses that have been highly overlearned, and by holding all relevant stimulus conditions constant with the exception of those resulting from 5"s own movements, we can create an experimental situation in which it is reasonable to assume that performance is limited primarily by the capacity of the motor system. The motor system in the present case is defined as including the visual and proprioceptive feedback loops that permit S to monitor his own activity. The information capacity of the motor system is specified by its ability to produce consistently one class of movement from among several alternative movement classes. The greater the number of alternative classes, the greater is the information capacity of a particular type of response. Since measurable aspects of motor responses, such as their force, direction, and amplitude, are continuous variables, their information capacity is limited only by the amount of statistical variability, or noise, that is characteristic of repeated efforts to produce the same response. The information capacity of the motor Editor's Note. This article is a reprint of an original work published in 1954 in the Journal of Experimental Psychology, 47, 381391.
Chaos? in Physiological Systems

Over the last two decades chaotic dynamical systems analysis has become a standard tool for systems analysis in the hydrodynamics of turbulence, in mechanical systems, and in electrical signals. The label “chaotic” referes to the lack of predictability of the weather and other complex systems. We can use “chaos” theory to enhance our understanding of cardiovascular pressures, flows, heart rates, and tracer exchanges. “Chaos” is the descriptor applied to the state of a system that is unpredictable, even though bounded. Poincare (1880) observed that some simple differential equations resulted in unpredictable behavior. But, as brought forcefully to our attention in modern times by Lorenz (1963), the unpredictability is not necessarily equivalent to randomicity. There is no reason to think that biological systems must be chaotic, and Glass and Malta (1990) argue that biochemical systems are in general not chaotic, so in this essay the focus is on the idea that consideration of chaotic and fractal aspects of systems augments our power to examine and interpret data, and perhaps to characterize the system.
Fibre-based source of femtosecond pulses tunable from 1.0 to 1.3 [micro sign]m

Tunable short-pulse generation in the spectral range 1030–1330 nm with an all-fibre source is demonstrated. A compact system with a femtosecond Yb fibre oscillator and a photonic crystal fibre relies on the soliton self-frequency shift to cover the wavelengths of primary interest to biological/biomedical imaging deep in tissue. Continuous tuning of <100 fs pulses with energies in the range 0.1–0.5 nJ is accomplished by adjusting the pulse energy.
Conservation of images

Images are being generated at an ever increasing rate, while new imaging technologies are also appearing all the time. The archivist must predict the archival stabilities of all these images. He needs to know how mechanisms of image deterioration results of accelerated ageing tests applicable to those degradation mechanisms and archival storage recommendations. These needs were discussed for the following image types: photographic (silver halide); electrostatic; magnetic; optical disc; vesicular; diazo; thermal and ink jet. The author considerd that only the silver image type is currently archivally acceptable. Recommends that machine-readable records should not be conserved as such but transferred to human readable microfilm. The need for trained image conservators is stressed.
Relation Extraction from Community Generated Question-Answer Pairs

Community question answering (CQA) websites contain millions of question and answer (QnA) pairs that represent real users’ interests. Traditional methods for relation extraction from natural language text operate over individual sentences. However answer text is sometimes hard to understand without knowing the question, e.g., it may not name the subject or relation of the question. This work presents a novel model for relation extraction from CQA data, which uses discourse of QnA pairs to predict relations between entities mentioned in question and answer sentences. Experiments on 2 publicly available datasets demonstrate that the model can extract from 20% to 40% additional relation triples, not extracted by existing sentence-based models.
BLACKPOLL WARBLER (DENDROICA STRIATA) FAT DEPOSITION IN SOUTHERN NOVA SCOTIA DURING AUTUMN MIGRATION

There is considerable evidence that the Blackpoll Warbler (Dendroica striata) undertakes a non-stop, transoceanic, fall migration from New England and Atlantic Canada to South America. However, this unique migration strategy is not yet clearly understood. Based on flight range esti- mates, Blackpoll Warblers must require large amounts of fat for this flight. I captured Blackpoll Warblers during fall migration on Bon Portage Island, a small island off southern Nova Scotia, to determine if Blackpoll Warblers either arrive with, or remain on the island and deposit, the large fat reserves necessary for their migration. Most Blackpoll Warblers did not arrive at Bon Portage with sufficient fat reserves to complete transoceanic migration from Nova Scotia to South America. Furthermore, although young Blackpoll War- blers did show moderate rates of diurnal fat deposition while on Bon Portage, most did not remain long enough to accumulate the necessary fat reserves for transoceanic migration. I conclude then, that Bon Portage Island is not one of the final sites for Blackpoll fat deposition, and I discuss several possible explanations for these results.
Reducing Cardiovascular Risk Using Genomic Information in the Era of Precision Medicine

With the pace of current advances in genomics technologies, we are fast approaching an era when patients will have complete genome sequence information on which clinicians will need to act when making routine clinical decisions. Precision medicine is “an approach to disease treatment and prevention that seeks to maximize effectiveness by taking into account individual variability in genes, environment and lifestyle.”1 One central aim of the recently launched US Precision Medicine Initiative is the return of genetic results for clinical utility. Atherosclerotic cardiovascular disease (CVD), the leading cause of death in men and women, is a chronic disease influenced by lifelong exposure to inherited and environmental risk factors. The major clinical and biochemical atherosclerosis risk factors for coronary heart disease (CHD) and other forms of CVD have been well defined over the past 50 years by prospective population cohorts like the Framingham Heart Study and resulting randomized, controlled treatment trials (RCTs). Genetics for CVD risk prediction provides the opportunity to more precisely identify individuals at high risk for developing disease for whom preventive therapy can be directed. Article, see p 1181 Our initial understanding regarding genetic risk for myocardial infarction and other forms of CHD has focused on rare ( 50 common (>1:20 carrier rate) gene variants with strong evidence for modest increases in CHD risk,6 and >150 common genetic variants with strong evidence for modest alterations of levels of key lipid fractions.7 Despite many novel discoveries, …
Expectancy Value Models of Attitude Measurement: A Measurement Problem:

Expectancy value models of attitude have become increasingly popular in recent years and have inspired a large and growing body of research. The models to date are largely based on interpretations of Rosenberg's [13] or Fishbein's [6] model of attitudes. Although the literature has discussed different scaling procedures, most researchers employ fiveto sevenpoint Likert or bipolar type scales for measurement of the independent variables "belief" (Bi) and "desirability" (a,).1 The differing techniques and opinions of the various researchers in this field are thoroughly discussed and reviewed by Wilkie and Pessemier [ 17]. Their review reveals that the marketing literature investigating attitudes has become quite sophisticated and refined. However, there is an important measurement problem in this area that has only been alluded to [2, 3] and which needs specific attention. This 'is not to detract from previous work but simply an attempt to improve future efforts. Researchers in marketing have examined both additive [4] and multiplicative [1, 15] functional forms for the independent variables in the expectancy value models. Both Fishbein and Rosenberg specify the combinatorial rule as multiplicative [5]. An important scaling consideration in tests of multiplicative models is presented here. Advocacy of a multiplicative composition rule implies the desirability of that rule relative to alternative rules. But multiplication of scales, in order to be logically meaningful, requires the existence of a true rational zero point on both the measures entering into
Red cell glutathione and glutathione reductase in cystic fibrosis.

SummaryRed blood cell glutathione reductase and whole blood total (oxidized and reduced) glutathione were assayed in cystic fibrosis subjects and non-cystic fibrosis controls. Glutathione reductase...
Emotionally Focused Couple Therapy An Interview With Scott Woolley, PhD

Dr. Shea Dunham interviews Dr. Scott Woolley about Emotionally Focused Couple Therapy (EFT). Dr. Woolley discusses what attracted him to EFT, the founders of EFT and the differences in their approaches, key components of the model, diversity, and how pathology is viewed from an EFT perspective. Finally he discusses the research base of EFT.
233 HEMODYNAMIC COMPROMISE REJECTION PREDICTS FUTURE CARDIAC ALLOGRAFT VASCULOPATHY AND NONFATAL MAJOR ADVERSE CARDIAC EVENTS.

Hemodyanamic compromise rejection (HCR) has been reported to be between 5 and 20% in the cardiac transplantation population. There has been controversy as to whether this form of rejection leads to a higher incidence of cardiac allograft vasculopathy (CAV) and nonfatal major adverse cardiac events (nf-MACE, defined as acute myocardial infarction, congestive heart failure, percutaneous cardiac intervention, need for implantable cardiac defibrilator, cerebral vascular accident, peripheral vascular disease). In our program, HCR is defined as heart failure symptoms associated with left ventricular ejection fraction ≤ 40%, cardiac index ≤ 2.0 L/min/m 2 , and the need for inotropic support. Between January 1994 and December 2003, 487 heart transplants were performed at our institution. There were 86 episodes of HCR, 23 occurring less than 30 days (early HCR) and 63 occurring greater than 30 days (late HCR) after heart transplantation. Compared to those patients without HCR (control group), 5-year survival was significantly less in those patients with early HCR (early HCR 47.8% vs control 71.3%, p = .008). The incidence of nf-MACE and CAV was without difference between these two groups. However, more patients in the early HCR group died and did not have the opportunity to develop nf-MACE and CAV. For patients with late HCR, 5-year survival and nf-MACE was comparable compared to the control group. However, there was increased development of CAV at 5 years (33.3% vs 21.7% for control, p = .049). For early and late HCR combined, there was significantly more nf-MACE compared to the control group (12.8% vs 5.1%, p = .011). Conclusion HCR less than 30 days of transplant confers poor 5-year survival, and late HCR is associated with greater development of CAV at 5 years. Overall, HCR is associated with the development of nf-MACE. Modification of subsequent maintenance of immunosuppresion and/or careful monitoring need to be pursued in these patients in order to improve outcome.
Incident chronic kidney disease: trends in management and outcomes.

Background Management trends in early chronic kidney disease (CKD) and their associations with clinical outcomes have not previously been reported.
The Morphology of Dust Emission in Planetary Nebulae and Proto-Planetary Nebulae

This review covers recent results from ground based mid-infrared (mid-IR; 8–25μm) imaging of thermal dust emission. The mid-IR images of proto-PNe show evidence for axially symmetric superwinds. In young PNe, the dust appears to be well mixed with the gas in the ionized gas regions. In carbon rich PNe and proto-PNe, the 11.3#x03BC;m feature attributed to PAHs appears more spatially extended than “continuum” dust emission and the near-IR (1–3#x03BC;m) excess appears spatially coincident with mid-IR dust emission. This review is not meant to cover the broader topic of dust in PNe and proto-PNe and we refer the reader to (Barlow 1993) for the most recent broad review.
Reminiscing together: joint experiences, epistemic groups, and sense of self

In this essay, I consider a kind of social group that I call ‘epistemic’. It is constituted by its members’ possession of perceptually grounded common knowledge, which endows them with a particular kind of epistemic authority. This authority, I argue, is invoked in the activity of ‘joint reminiscing’—of remembering together a past jointly experienced event. Joint reminiscing, in turn, plays an important role in the constitution of social and personal identity. The notion of an epistemic group, then, is a concept that helps explain an important aspect of a subject’s understanding of who she is.
Right Heart Catheterization

In the catheterization laboratory and the intensive care unit, right heart catheterization (RHC) can provide vital physiologic information. Although clinical trials have never demonstrated improved outcomes with RHC, when used appropriately, it is viewed as an invaluable tool for the hemodynamic monitoring and management of critically ill patients with cardiovascular disease.
Nutritional management of acute pancreatitis

Purpose of review Acute pancreatitis is one of the most common causes for hospitalization related to a gastrointestinal disorder. It carries significant morbidity, and when severe, significant mortality. Multiple interventions have been studied to treat pancreatitis. Of all these interventions, none is more important or impactful than nutrition. Recent findings High-quality evidence along with society guidelines have recommended the use of enteral nutrition over parenteral nutrition in patients with pancreatitis. Recent systematic reviews and meta-analyses have been published and will be reviewed here. Summary The use of enteral nutrition has been demonstrated to decrease mortality and infectious complications compared with parenteral nutrition. The ideal timing of initiating enteral nutrition is not clear, however, early nutrition (within 48 h) appears to be safe and tolerated. Most studies have utilized nasojejunal feeding tubes; however, some patients may tolerate nasogastric or even oral refeeding. Clinicians who manage patients with pancreatitis must be aware of the critical role of nutrition in preventing pancreatitis-related complications.
A Directory to International LIS Education Accreditation Processes: Part II

Let us continue to look at the LIS education accreditation processes across the world in Part II of this directory. This time, readers will find information on the accreditation processes for higher education in general, and LIS education in particular in Ireland, Germany, and South Africa. In Ireland, the Library Association of Ireland (LAI) accredits only LIS programs that meet the academic quality assurance requirements of the state agency Quality and Qualifications Ireland (QQI). In South Africa, a LIS program provider will first contact the Library and Information Association of South Africa (LIASA) for input before submitting the accreditation application to The Council on Higher Education (CHE), the statutory body in South Africa for quality assurance in higher education. In Germany, the Accreditation Council is the central decision-making body that is responsible for the accreditation of all study programs of any disciplines in Germany. There is no specialized accreditation institution for LIS accreditations, and German Library Associations is not involved in the LIS education accreditation processes.
Health and quality of life (QOL) issues in four groups of lung cancer patients: Low-dose computed tomography (LDCT) screened, chest x-ray detected, incidentally found, and routinely diagnosed.

1610 Background: Low dose computed tomography (LDCT) scans have reduced lung cancer deaths by 20.3% in high risk populations, although there is an unknown balance between the benefits and harms of LDCT scans as a screening tool. Our purpose was to compare health-related QOL issues among lung cancer patients who were initially detected by LDCT scans; 4 comparison groups included: lung cancer diagnosed by a screening chest X-ray, as an incidental finding from procedures taken for other medical reasons, or based on symptoms indicative for lung cancer and routinely diagnosed, and individuals who were LDCT screened but found no lung cancer (controls who participated in Mayo’s lung cancer CT screening trial). Methods: A total of 1,658 lung cancer patients (cared at Mayo Clinic) in the 4 groups (37, 151, 389, and 1081 respectively) and 488 controls were compared on following patient-reported outcomes (collected via validated tools): overall QOL, four symptoms (cough, pain, dyspnea, fatigue), mental/ physical/ em...
Design and investigation of an enhanced magneto-mechanical nonlinear energy harvester

In this work, a unique magneto-mechanical energy harvester is fabricated, modeled, and investigated. The magnetomechanical energy harvester consists of a levitated magnet, forming a magnetic spring, connected to oblique, mechanical springs. Upon base-excitation, the levitated magnet experiences nonlinear forces in the direction of motion due to the mechanical and magnetic spring. Voltage is induced in a coil placed around the body of the energy harvester. Results confirm the oblique, mechanical springs and magnetic springs introduce geometric negative and hardening stiffnesses. This behavior allows for the use of disc magnets instead of ring magnets, reducing energy dissipation due to Coulomb damping. Forward and reverse sinusoidal frequency sweep measurements at a constant acceleration of 0.75g shows the characteristic backbone curve exhibited by Duffing-type nonlinear oscillators. The frequency response of the proposed device demonstrates the broadband capabilities with a measured peak power of approximately 7-mW at 15Hz. Results from the model are in good agreement with data obtained from the experiment.
Management of Posterior Cruciate Ligament Tibial Avulsion Injuries: A Systematic Review:

Background:Tibial-sided avulsion injuries of the posterior cruciate ligament (PCL) generally require surgical intervention. No consensus exists concerning the optimal surgical treatment approach fo...
Figuras del sujeto

En el presente articulo se confrontan las proposiciones de Touraine y Lacan en torno al sujeto, partiendo de un breve recuento de lo que dijo el a critica estructuralismo ta respecto al tema. El punto de vista que aqui se sostiene es el del psicoanalisis y el objetivo es mostrar los limites del pensamiento sociologico sobre en el tema del sujeto y su constitucion.”. Pero,, ?podria atribuirse este fracasoe f racaso a una simple inadecuacion de las categorias sociologicas para pensar el sujeto? ?O es algo particular al enfoque de Touraine, incluso si el suyo es el mas elaborado esfuerzo por entender el proceso social como resultante de la accion del sujeto en acto obra en el movimiento social? Tal vez la falla la falla del pensamiento sociologico respecto al sujeto revela algo mas profundo, algo que podria interpretarse como un obstaculo epistemologico, como un sintoma que insiste y que esta aun por a tratar. La hipotesis que se expone es que la Sociologia errara su sujeto si no se redefine como disciplina que considera la accion del lenguaje y el discurso en la constitucion de los sujetos en la sociedad y de los nexos que los unen. En ese caso, sin embargo, el “sujeto sociologico” vendria a ser identico al sujeto del significante postulado por Lacan.
Factors that affect scientists' knowledge sharing behavior in health and life sciences research communities

In the past decade, the number of knowledge networking platforms has been rapidly increasing, in part to support data intensive and cross-disciplinary research in growing fields such as health and life sciences. To promote knowledge sharing, it is important to understand why scientists want to or hesitate to share knowledge with other research communities. We examined five determining factors (reciprocal benefit, anticipated relationship, reputation, altruism and fear of being scooped) that impact scientists' intention to share explicit and implicit knowledge and built a predictive research model. The proposed model was then evaluated using partial least squares (PLSs) method against 141 valid survey responses. The results suggested that reciprocal benefit and fear of being scooped were significant in affecting implicit and explicit knowledge sharing behavior in health and life sciences research communities. Reputation had a main effect on scientists' intention to share explicit knowledge and anticipated relationship had an effect on scientists intention to share implicit knowledge. However, altruism showed no main effects on knowledge sharing. We concluded by discussing strategies, derived from analyzing our survey data, to assist user experience practitioners in designing and promoting knowledge networking support in complex scientific domains. This study examines the factors that affect knowledge sharing behavior in health and life sciences research communities.Two types of knowledge are considered; implicit knowledge and explicit knowledge.Reciprocal benefit and fear of being scooped are critical in explicit and implicit knowledge sharing behavior.Anticipated relationship influences one's implicit knowledge sharing behavior.Reputation affects one's explicit knowledge sharing behavior.
Opaque Liabilities, Learning, and the Cost of Equity Capital for Insurers

Analyzing the top 100 U.S. property-liability insurers, we find that the cost of equity capital is negatively related to insurers’ underwriting performance, but not their investment performance. The difference is attributable to opaque insurer liabilities and investor learning. We also find that the capital market and product market imperfections are important determinants of insurers’ cost of equity capital. We address endogeneity concerns using property losses from natural disasters as an instrumental variable. Overall, our evidence contributes to the important literature examining insurers’ cost of capital, and it highlights that opaque liabilities are a distinguishing feature of insurers in determining their cost of capital.
The Role of Magnetism in High-Tc Superconductivity

A magnetic contribution toward the transition to the high-Tc superconductivity state is described from our recent experimental data on effects of paramagnetic moment and magnetic field sweep rate. Also previous related information taken from our studies and the work of others is reviewed and interpreted. The magnetic contributor is interpreted to be related to spin fluctuations from anti-ferromagnetism and to a spin density wave. Ultimately, this spin density wave couples with a charge density wave due to the system of holes. In terms of quasiparticles this interpretation relates to spinons and holons.
A Single-Institution Experience in the Preoperative Selection of DCIS Patients for IORT using the ASTRO Consensus Guidelines.

Abstract Purpose Intraoperative radiation therapy (IORT) as a form of accelerated partial breast irradiation (APBI) is controversial given the limited evidence to support its efficacy. However, it remains an attractive option for low-risk patients with ductal carcinoma in situ (DCIS), who derive a small absolute benefit in local control with standard whole breast irradiation (WBI). We examine how the American Society for Therapeutic Radiation Oncology (ASTRO) APBI consensus guidelines (CG) may be applied to the preoperative selection of patients with DCIS for IORT and determine treatment outcomes by CG group. Methods and Materials We identified patients with biopsy-proven pure DCIS enrolled in an institutional prospective registry IORT database using the Zeiss Intrabeam® device between September 2013 and February 2017. Based on available preoperative clinicopathologic information, patients were deemed suitable, cautionary, or unsuitable for IORT according to the ASTRO CG. Change in CG group based on final pathologic diagnosis was determined, and additional therapy was recommended for unsuitable patients. Outcome in terms of ipsilateral breast tumor recurrence was determined. Results A total of 61 DCIS lesions in 60 patients were treated with IORT. Preoperatively, 21 patients (35%) were suitable and 36 (59%) were cautionary. Four (6%) were unsuitable because of lesion size but declined WBI. Final pathologic diagnosis changed the CG grouping of 10 patients (16%) because of either occult high-grade disease in 2 (3%) or close/positive margins in 8 (13%). Ultimately 12 patients total were considered unsuitable, of whom 8 (66%) accepted additional WBI after IORT. At a median follow-up of 2.2 years, ipsilateral breast tumor recurrence was identified among 2 suitable, 1 cautionary, and no unsuitable patients. Conclusion Further investigation is necessary to refine selection of patients with DCIS who may be optimally treated with IORT alone. High acceptance of additional therapy among unsuitable patients resulted in excellent outcomes. The use of biomarkers in addition to traditional clinical and pathologic factors may help to better select patients for IORT.
Comparing the accuracy of MODIS data products for vegetation detection between two environmentally dissimilar ecoregions: the Chocó-Darien of South America and the Great Basin of North America

The daily images produced by the MODIS (Moderate Resolution Imaging Spectroradiometer) sensor aboard the Terra and Aqua satellites have been widely used to monitor global vegetation. Using these da...