cssi/SciSciGPT-SciSciNet huggingface dataset:
Selective 5ht-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex

Evidence suggests that the serotonin 5HT-1 receptor site is functionally linked to adenylate cyclase in the brain, but a biochemical effector system which is linked to the serotonin 5HT-2 receptor site has not been found. In the present paper we report an investigation of 5HT stimulated phosphatidylinositol (PI) hydrolysis in rat cerebral cortex and have found that selective 5HT-2 antagonists (pizotifen and ketanserin) block 5HT's effect upon PI metabolism. These data suggest that 5HT stimulated PI hydrolysis is mediated by the 5HT-2 binding site.
CD47 blockade improves survival after transplantation of steatotic liver allografts

INTRODUCTION: Nearly 22 million people suffer from heart failure (HF) worldwide. Heart transplantation is the only viable treatment option, but donor organ shortage and immunosuppression remain significant challenges. The creation of a bioartificial heart could overcome limitations. In this work, we recellularized human heart matrix slices with human induced pluripotent stem (iPS) derived cardiomyocytes to create contracting human myocardium.
Brianmyia stuckenbergi, a new genus and species of Prosopochrysini from South Africa (Diptera: Stratiomyidae)

A new genus and species of Stratiomyidae, Brianmyia stuckenbergi gen. et sp. n., are described from the Drakensberg, KwaZulu-Natal, South Africa. The new genus is placed in the tribe Prosopochrysini of the subfamily Stratiomyinae and is the first genus and species of this tribe known from southern Africa.
A scheme for little languages in interactive graphics

SUMMARY Programming environments for interactive graphics software typically have a multiplicity of tools and applications. Many of these programs contain ad hoc ‘little language’ interpreters 1 that do many similar things in needlessly different ways. In particular, many little languages have, in addition to their special-purpose constructs, vestigial support for ordinary programming, such as variables, loops and conditionals. If a single, standard programming language were the basis for all these little languages, they could have complete, coherent programming semantics; they could communicate with each other more easily; no design work for basic constructs would be needed; and interpreter implementation work would be saved. The approach of reusing and extending the same core language and interpreter for a variety of little languages is the extension language approach. Scheme is proposed as a good choice for such a core language. Scheme is a simple, elegant, high-level programming language. Extendable implementations are readily available in C source form. Example applications in Scheme from interactive graphics are presented that would be nearly impossible to code in a typical scripting language and very tedious to code in a lower-level implementation language such as C.
Bioinformatic Resources of microRNA Sequences, Gene Targets, and Genetic Variation.

Variation in quantitative gene expression has been observed in natural populations and associated with various complex traits/phenotypes such as risks for common diseases and drug response. MicroRNAs (miRNAs), a family of small, non-coding RNA molecules, have been demonstrated to be an important class of gene regulators that mostly downregulate gene expression at the post-transcriptional level. A comprehensive and reliable catalogue of miRNAs and miRNA gene targets is critical to understanding the gene regulatory networks. Though experimental approaches have been used to identify many miRNAs and their gene targets, due to cost and efficiency, currently miRNA and target identification still largely relies on computational algorithms. We reviewed several widely-used bioinformatic resources of miRNA sequences and gene targets that take advantage of the unique characteristics of miRNA-mRNA interactions, experimental validation, as well as the integration of sequence-based evidence and microarray expression data. Furthermore, given the importance of miRNAs in regulating gene expression, elucidating expression quantitative trait loci (eQTLs) involved with miRSNPs or miR-polymorphisms will help improve our understanding of complex traits. We reviewed the available resources of miRNA genetic variation, and the current progress (e.g., the 1000 Genomes Project) in detailing the genetic variation in miRNA-related single nucleotide polymorphisms (SNPs). We also provided our perspectives of the potential impact of next-generation sequencing on the research of miRNAs, gene targets and miRSNPs. These bioinformatic resources may help interpret experimental and association study results, thus enhancing our knowledge of the dynamic gene regulatory networks and the physiological pathways for complex traits and phenotypes. Prospectively, these bioinformatic resources of miRNAs will need to address the challenges due to the application of next-generation sequencing in miRNA research.
Testing DSM-5 in routine clinical practice settings: feasibility and clinical utility.

The fifth edition of the Diagnostic and Statistical Manual (DSM-5) attempts to capture the latest scientific advances and to enhance the reliability of diagnostic criteria. Among the new manual's most noticeable differences is the inclusion of patient-reported measures to identify initial clinical status and monitor progress. In 2011 and 2012, clinicians and their patients from the United States, Canada, Australia, and the United Kingdom undertook to assess the clinical utility and feasibility of the new manual. The results of the field trials are reported.
Fragments of Regionalism: The Limits of Southern California Governance

ABSTRACT:This paper explores the manifestations of regional governance in Southern California. The author evaluates whether three regional public authorities, empowered to address areawide transpor...
Parallels between attention deficit hyperactivity disorder and behavioral deficits produced by neurotoxic exposure in monkeys.

Attention deficit hyperactivity disorder (ADHD) is a disability that affects between 3 and 7% of children, with a significant number of individuals continuing to be affected into adolescence and ad...
Profile-based focused crawling for social media-sharing websites

We present a novel profile-based focused crawling system for dealing with the increasingly popular social media-sharing websites. In this system, we treat the user profiles as ranking criteria for guiding the crawling process. Furthermore, we divide a user's profile into two parts, an internal part, which comes from the user's own contribution, and an external part, which comes from the user's social contacts. In order to expand the crawling topic, a cotagging topic-discovery scheme was adopted for social media-sharing websites. In order to efficiently and effectively extract data for the focused crawling, a path string-based page classification method is first developed for identifying list pages, detail pages, and profile pages. The identification of the correct type of page is essential for our crawling, since we want to distinguish between list, profile, and detail pages in order to extract the correct information from each type of page, and subsequently estimate a reasonable ranking for each link that is encountered while crawling. Our experiments prove the robustness of our profile-based focused crawler, as well as a significant improvement in harvest ratio, compared to breadth-first and online page importance computation (OPIC) crawlers, when crawling the Flickr website for two different topics.
MODELING JOB PERFORMANCE IN A POPULATION OF JOBS

The Army Selection and Classification Project has produced a comprehensive examination of job performance in 19 entry-level Army jobs (Military Occupational Specialties) sampled from the existing population of entry-level positions. Multiple methods of job analysis and criterion measurement were utilized in a subsample of nine jobs to generate over 200 performance indicators, which were then used to assess performance in a combined sample of 9,430 job incumbents. An iterative procedure involving a series of content analyses and principal components analyses was used to develop a basic array of up to 32 criterion scores for each job. This basic set of scores formed the starting point of an attempt to model the latent structure of performance in this population of jobs. After alternative models were proposed for the latent structure, the models were submitted to a goodness-of-fit test via LIS-REL VI. After accounting for two components of method variance, a five-factor solution was judged as the best fit. The implications of the results and the modeling procedure for future personnel research are discussed.
Weak interactions and the baryonic current

We conjecture that neutrino scattering probes the baryonic currents of hadrons. A new model of $\ensuremath{\Delta}S=0$, $\ensuremath{\Delta}Q=0$ semileptonic weak interactions is constructed with numerous experimental consequences.
Stakeholder Service Perspectives: A Triadic Analysis of Service Quality in South Mississippi Fine Dining Restaurants

The primary goal of this study was to replicate and extend earlier work by Fallon and Schofield that examined the relationship between customer, wait staff and manager perceptions in fine dining restaurants. Subjects included 266 participants from three fine-dining restaurants in Hattiesburg, Mississippi. Participants completed a survey instrument revised from the Fallon and Schofield instrument. Participants ranked the most important question in each section of the survey instrument to determine which factor in each quality dimension was most important. There were no significant differences among the participants by restaurant. Composite data were examined to identify differences in perception among participants using analysis of variance. A relationship between wait staff and customers confirmed the earlier work by Fallon and Schofield that managers ranked quality service dimensions higher than other participant groups. Customers ranked service higher as compared with wait staff, which is a new finding ...
Acceleration sensitivity of SAW oscillators: a market survey

The results of a market survey on both fixed frequency and voltage controlled surface acoustic wave (SAW) oscillators (VCO) are presented. The survey attempts to establish the acceleration sensitivity performance baseline for commercially available SAW oscillators and to determine the feasibility of using them to meet the requirements of future systems. Some of the observed advantages and disadvantages of particular SAW oscillator design configurations are reported. Results will lead to a greater understanding of the ability of commercial vendors to satisfy the hostile vibration environment of the battlefield. >
Educating children to cope with death: A preventive model

Today's children increasingly are exposed to death in their environments. The professional literature indicates potentially adverse effects of unresolved childhood grief. These factors point to the need for death education to be included in the school curriculum, with a focus on promotion of health and prevention of disorders. School psychologists should be in the forefront of advocating, developing, and implementing such a program, in collaboration with the teachers. This article reviews what is known about children's conceptions of death, how children grieve, and relevant research. The guidelines of clinicians in the field are presented on such issues as explaining death to children, their attending funerals, and treating bereaved youths and their families. In addition the broad outline for a death education program is presented, incorporating developmental and theoretical principles about children's grieving process. The curriculum's goals are to provide students with appropriate information about the life cycle, to identify affective issues associated with grief, and to facilitate the development of effective coping strategies for managing bereavement reactions. A death education program may help students to more fully appreciate life while realizing that death is a natural part of the life process.
Flexible Firms and Labor Market Segmentation: Effects of Workplace Restructuring on Jobs and Workers

Employers in all industrial societies have sought greater flexibility in their employment systems. This article discusses some key ways in which employers have sought to restructure their workforces to become more flexible and the consequences of such restructuring for workers and jobs. The author argues that U.S. employers' use of numerical and functional flexibility strategies has led to a division between organizational insiders (standard employment relations) and outsiders (who have nonstandard work arrangements). The consequences of working in nonstandard employment relations differ depending on workers' individual and collective control over skills and other valued resources.
Phenotypes associated with Saccharomyces cerevisiae Hug1 protein, a putative negative regulator of dNTP Levels, reveal similarities and differences with sequence-related dif1

Saccharomyces cerevisiae Hugl is a small protein of unknown function that is highly inducible following replication stress and DNA damage. Its deletion suppresses the lethality of deletion of checkpoint kinase Mecl. Although DNA damage responses were largely normal in the HUG1 deletion mutant, we found enhanced resistance towards heat in logarithmic phase. In response to simultaneous carbon and replication stress, overall growth delay and less pseudohyphal filament formation were evident. These novel phenotypes are shared with deletion mutants of the negative regulators of ribonucleotide reductase, Difl and Smll. Microarray analysis showed the influence of Hugl on the expression of a large number of transcripts, including stress-related transcripts. Elevated dNTP levels in hugl Δ cells may result in a stress response reflected by the observed phenotypes and transcript profiles. However, in contrast to a deletion of structurally related Difl, Rnr2-Rnr4 subcellular localization is not grossly altered in a Hugl deletion mutant. Thus, although Hugl appears to be derived from the Rnr2-Rnr4 binding region of Difl, its mechanism of action must be independent of determining the localization of Rnr2-Rnr4.
THE APPLICATION OF THE MAIZE-DERIVED GENE COMPETITION MODEL TO THE PROBLEM OF DOSAGE COMPENSATION IN DROSOPHILA

The gene competition model, originally formulated from studies on the regulation of alcohol dehydrogenase activity in maize, is also applicable to the phenomenon of dosage compensation in Drosophila. The model accounts for the absence of dosage compensation in sex determination.
Induratio penis plastica. Priapismus. Erkrankung der Schwellkörper

Die im Rahmen dieses Handbuchs 1927 veroffentlichte Monographie CallomonS (1927a) uber die Induratio penis plastica hat — wenn auch bis heute offenbar nicht wieder in so vollkommener Weise — verschiedentlich Nachfolge gefunden, z. B. durch Scherber (1935), Molineus (1951) usw.
Pure Red Cell Aplasia in Major ABO-Mismatched Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Severe Pancytopenia

Abstract In major ABO-mismatched allogeneic hematopoietic stem cell transplantation (HSCT) persistence of antidonor isohemagglutinins leads to pure red cell aplasia (PRCA). To investigate severe pancytopenia noted in a previous study of PRCA, we analyzed all major ABO-mismatched HSCT between January 2003 and December 2012. Of 83 PRCA patients, 13 (16%) had severe pancytopenia. Severe pancytopenia was defined as an absolute neutrophil count (ANC)
Child Abuse and Neglect

Child abuse, long neglected by both society and medicine, is now a focus of public attention. Cases of suspected maltreatment are often featured in the news media and argued in the courts. Some cases raise profound questions about the relative rights of parents, children, and those charged with child abuse. Allegations of sexual abuse by celebrities have raised questions of privacy both for those charged with abuse and for their alleged victims, and cases of fatal physical abuse among middle-class families have challenged the stereotype that violence in the home occurs only among the poor or disadvantaged. Physicians and others . . .
Instructional Leadership: New Responsibilities for a New Reality

Dans un paysage educatif de plus en plus complexe, les bibliothecaires charges de coordonner les services d'instruction dans les universites doivent assumer les responsabilites de veritables leaders instructionnels, en faisant de la culture de l'information un objectif strategique de la bibliotheque. Le role du leader en instruction est caracterise par une vision globale, la capacite de planifier, d'inspirer ses collegues, de favoriser la communication entre les bibliothecaires comme au sein du campus, ainsi que par l'aptitude a innover et a repenser l'instruction.
Morphology and Function of Hohokam Small Structures

ABSTRACTLarge numbers of prehistoric Hohokam structures less then 9 m2 in size have been excavated in the Salt-Gila Basin. These small structures occur both in isolated situations and within more substantial sites with large structures. Historic data for groups living in southern Arizona and northern Mexico reveal that small structures were constructed for a variety of uses, primarily for storage or temporary habitation. The function of historic small structures in the settlement-subsistence system included temporary restriction of personnel viewed as dangerous to the community and shelter for personnel temporarily separated from the community caring for crops or in pursuit of wild food resources. Given these historic data, it is possible to attempt an interpretation of the uses of prehistoric small structures.
Jewish fish (ΙΧΘΥΣ) in post-supersessionist water: Messianic Judaism within a post-supersessionistic paradigm

This article defines, explains and argues for the necessity of a post-supersessionistic hermeneutical posture towards the New Testament. The post-supersessionistic reading of the New Testament takes the Jewish nature of the apostolic documents seriously, and has as its goal the correction of the sin of supersessionism. While supersessionism theologically is repudiated in most corners of the contemporary church through official church documents, the practise of reading the New Testament continues to exhibit supersessionistic tendencies and outcomes. The consequence of this predominant reading of the New Testament is the continued exclusion of Jewish ethnic identity in the church. In light of the growing recognition of multiculturalism and contextualisation on the one hand, and the recent presence of a movement within the body of Messiah of Jewish believers in Jesus on the other, the church’s established approach to reading Scripture that leads to the elimination of ethnic identity must be repudiated alongside its post-supersessionist doctrinal statements. This article defines terms, explains consequences and argues for a renewed perspective on the New Testament as an ethnic document; such a perspective will promote the church’s cultivation of real embodied ethnic particularity rather than either a pseudo-interculturalism or the eraser full ethnicity.
An analysis of insulation requirements for metal-clad switchgear

Metal-clad switchgear, as defined in American Standards, “Consists of an indoor or outdoor metal structure containing switching equipment and other associated equipment, such as instrument transformers, buses, and connections. The transformers, buses and connections are insulated and placed in separate grounded compartments. The circuit breaker is equipped with self-coupling disconnecting devices and etc.”
Raman and Conductivity Analysis of Graphene for Biomedical Applications

In this study, we present a comprehensive investigation of graphene's optical and conductive properties using confocal Raman and a Drude model. A comparative analysis between experimental findings and theoretical predictions of the material's changes and improvements as it transitioned from three-dimensional graphite is also presented and discussed. Besides spectral recording by Raman, which reveals whether there is a single, a few, or multi-layers of graphene, the confocal Raman mapping allows for distinction of such domains and a direct visualization of material inhomogeneity. Drude model employment in the analysis of the far-infrared transmittance measurements demonstrates a distinct increase of the material's conductivity with dimensionality reduction. Other particularly important material characteristics, including carrier concentration and time constant, were also determined using this model and presented here. Furthermore, the detection of micromolar concentration of dopamine on graphene surfaces not only proves that the Raman technique facilitates ultrasensitive chemical detection of analytes, besides offering high information content about the biomaterial under study, but also that carbon-based materials are biocompatible and favorable micro-environments for such detection. Such information is valuable for the development of bio-medical sensors, which is the main application envisioned for this analysis.
Degrees of freedom in low rank matrix estimation

The objective of this paper is to quantify the complexity of rank and nuclear norm constrained methods for low rank matrix estimation problems. Specifically, we derive analytic forms of the degrees of freedom for these types of estimators in several common settings. These results provide efficient ways of comparing different estimators and eliciting tuning parameters. Moreover, our analyses reveal new insights on the behavior of these low rank matrix estimators. These observations are of great theoretical and practical importance. In particular, they suggest that, contrary to conventional wisdom, for rank constrained estimators the total number of free parameters underestimates the degrees of freedom, whereas for nuclear norm penalization, it overestimates the degrees of freedom. In addition, when using most model selection criteria to choose the tuning parameter for nuclear norm penalization, it oftentimes suffices to entertain a finite number of candidates as opposed to a continuum of choices. Numerical examples are also presented to illustrate the practical implications of our results.
The Promise and Challenge (and Reality) of Defining Therapist Expertise

This article is a commentary on Hill, Spiegel, Hoffman, Kivlighan, and Gelso’s interesting and thought-provoking article focused on defining psychotherapy expertise. I address Hill et al.’s inclusi...
Empathy is Not a Thermometer

We raise two objections to Slote’s article. First, empathy cannot provide information about the world in the direct way Slote proposes. Emotional contagion might be able to do so, but this type of process is different from the empathic one. Second, even if we accept his view of empathy, his claim that we make moral judgments via empathizing with the ‘warmth’ or ‘coldness’ of the actor seems misguided because, we usually empathize with the patient (not the actor), and we empathize with emotions, not “temperatures”.
Adverse Event Incidences following Facial Plastic Surgery Procedures: Incorporating FACE-Q Data to Improve Patient Preparation

Background:Before creation and validation of the FACE-Q by Pusic et al., adverse event types and incidences following facial cosmetic procedures were objectively measured and reported by physicians, potentially leading to misrepresentation of the true patient experience. This article analyzes and co
Teaching Social Work Students about Alcohol and Other Drug Use Disorders: From Faculty Learning to Pedagogical Innovation.

This article builds on prior research demonstrating that intensive faculty training in alcohol and other drug (AOD) identification and treatment methods can result in increases in AOD knowledge and teaching efficacy. We provide examples of how faculty participants in the Alcohol and Other Drugs Education Program have adapted their teaching in clinical practice, research methods, and addiction specialty courses as a result of participation in our immersion-based training program. Examples from 3 schools provide ideas for teaching innovations and serve as templates for faculty interested in advancing their teaching and the integration of AOD-related content into the social work curriculum.
The U.S. immigration debate: what’s all the shouting for?

Potential GDP growth has slowed by 1.3% a year. The main culprit is labor force decline. It follows logically that a more welcoming immigration policy would be responsive to our demographic challenges and thereby complementary to macroeconomic growth. Ironically, anger at immigration has grown in inverse proportion to actual immigration flows. There is little evidence that immigrants have negative impacts on the wages of native-born workers, and increased immigration would likely have a net positive fiscal impact. Based on these economic considerations, the U.S. immigration debate seems driven by much more heat than light.
Conventional and emerging renal biomarkers

The structural and functional complexity of the kidneys presents numerous challenges in assessing renal status. The kidneys are sensitive to events such as exposure to chemicals, low perfusion, immune system activity, and prerenal pathological conditions, such as diabetes, each of which may affect renal structure and function in distinct ways. Recent studies have demonstrated that several urinary biomarkers are more useful indices for detecting nephrotoxicity than conventional circulating biomarkers, such as blood urea nitrogen and creatinine. Some of these biomarkers include kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), urinary albumin (uALB), cystatin C (Cyst C), clusterin (CLU), and urinary total protein (uTP). These urinary biomarkers have the advantage over circulating biomarkers because sample collection for their assessment is noninvasive. A panel of biomarkers, compared to a single biomarker, is more likely to detect important changes and give rise to a richer description of renal impairment. This chapter describes the conventional and emerging renal biomarkers.
Reef-Building Corals and Identification of Enso Warming Episodes

Abstract Many chemical and physical changes that occur in the atmosphere and surface ocean are recorded in coral skeletons. In this chapter, we discuss some of the physical, chemical and isotopic changes observed in coral skeletons and their relationships with various climate-related forcing functions. Among the specific factors affecting coral growth and the chemical and isotopic composition of the accreted aragonite are those encountered during ENSO events: abnormal temperature and salinity, reduced nutrient and zooplankton supply, and variation in light intensity. We also determine the usefulness of coral skeletons for reconstructing ENSO records in the eastern tropical Pacific. We present records of stable oxygen and carbon isotopes in corals from the Galapagos Islands and the coast of Panama. We conclude that stable isotopic studies are adequate for tracking most minor and major ENSO events, but are insufficient for unequivocally determining the occurrences of all events or of catastrophic events, such as that which occurred during 1982-83. The catastrophic environmental stresses imposed on corals during such events result in cessation of skeletal accretion, and thus an absence of a significant portion of the record.
Stress and Coping Factors in the Epidemiology of Substance Use

The purpose of this chapter is to provide a systematic review of the role of stress and coping factors in substance use. In recent years, accumulating evidence from epidemiological studies has shown relationships between life stressors and substance use for each of the major phases of use: initiation, maintenance, and relapse. This research extends a line of investigation beginning with the tension reduction model of alcohol use (Conger, 1956; Cappell and Herman, 1972) and encompasses new studies of stress-related predictors of cigarette smoking, tranquilizers, and opiate use. Here I consider findings from field studies that provide evidence of stress-substance use relationships for each of the three phases. After detailed review of the field evidence, a final section discusses implications for theoretical models of substance use and abuse.
Overcoming the Stigma of Complications of Continent Cutaneous Diversion

The introduction of continent cutaneous diversions have increased the acceptability and decreased the stigmata associated with bladder cancer therapy. The understanding of the complications associated with continent cutaneous diversions is of vital importance for individuals caring for bladder cancer patients. The utilization of such techniques requires significant understanding of the immediate and long-term complications to allow for appropriate patient selection for individuals undergoing radical cystectomy. The appropriate selection criteria, immediate and late complications are reviewed. The chapter is organized by patient aspects such as capabilities, selection criteria, and QOL concerns. The complications are described by those associated with the reservoir, the continence mechanism or the stoma. This review serves as a valuable reference for the care of bladder cancer patients prior to and after receiving a continent cutaneous diversion.
Freshwater Fish Release Urinary Pheromones in a Pulsatile Manner

This study provides the first evidence in a fish that sex pheromone release may have an important, temporal component. This was accomplished using a visual dye and a radioactive tracer to record urination in the goldfish (Carassius auratus), a species known to release a spawning pheromone in urine. We found that goldfish release urine in a pulsatile manner at approximately 2-4 min intervals. Although there was no apparent sexual-dimorphism in urinary release among sexually inactive goldfish, ovulated females tended to urinate while rising into the weeds and spawning. Our study also suggests that a species difference exists in urinary pheromone release rates, as a pilot study of Eurasian ruffe (Gymnocephalus cernuus) demonstrated that females of this species urinate less frequently than goldfish. Together, these studies demonstrate that temporal characteristics of pheromone release are likely important to fish reproductive behavior and establish a new technique for studying this phenomenon.
Non-invasive assessment of liver fibrosis and prognosis: an update on serum and elastography markers

Introduction: Non-invasive assessment of fibrosis is increasingly utilized in clinical practice to diagnose hepatic fibrosis. Non-invasive assessment of liver fibrosis relies on biologic and/or phy...
A Double Fail-Safe Approach to Prevent Tumorigenesis and Select Pancreatic β Cells from Human Embryonic Stem Cells.

Summary The transplantation of human embryonic stem cell (hESC)-derived insulin-producing β cells for the treatment of diabetes is finally approaching the clinical stage. However, even with state-of-the-art differentiation protocols, a significant percentage of undefined non-endocrine cell types are still generated. Most importantly, there is the potential for carry-over of non-differentiated cell types that may produce teratomas. We sought to modify hESCs so that their differentiated progeny could be selectively devoid of tumorigenic cells and enriched for cells of the desired phenotype (in this case, β cells). Here we report the generation of a modified hESC line harboring two suicide gene cassettes, whose expression results in cell death in the presence of specific pro-drugs. We show the efficacy of this system at enriching for β cells and eliminating tumorigenic ones both in vitro and in vivo. Our approach is innovative inasmuch as it allows for the preservation of the desired cells while eliminating those with the potential to develop teratomas.
Equivariant K-theory and Resolution I: Abelian Actions

The smooth action of a compact Lie group on a compact manifold can be resolved to an iterated space, as made explicit by Pierre Albin and the second author. On the resolution the lifted action has fixed isotropy type, in an iterated sense, with connecting fibrations and this structure descends to a resolution of the quotient. For an Abelian group action the equivariant K-theory can then be described in terms of bundles over the base with morphisms covering the connecting maps. A similar model is given, in terms of appropriately twisted deRham forms over the base as an iterated space, for delocalized equivariant cohomology in the sense of Baum, Brylinski and MacPherson. This approach allows a direct proof of their equivariant version of the Atiyah–Hirzebruch isomorphism.
A STUDY ON CYBERCRIME WITH SPECIAL REFERENCE TO INTERNET USERS IN TIRUNELVELI DISTRICT

Millions of folks round the world use computers and the web every day. The internet represents both risk and opportunities for young people. The internet has become all pervasive in the lives of young people. We all use it in school, work even at home, computers have made us life easier, it has additionally brought some issues and agreement cybercrimes is me them. Cybercrime is one of the greatest common increasing crimes being steadfast today. This paper examines a study on cyber crime special reference to internet users in Tirunelveli district. A questionnaire investigation was lead surrounded by 150 internet users of Tirunelveli District.
The Romanticism of Elizabeth Barrett's Juvenile Poetics

This article traces enthusiastic language and tropes across the juvenilia of Elizabeth Barrett (later Browning) in order to establish her investment in the concept during her teens and early twenties. Barrett’s early autobiographical essays praise and emulate Romantic strong feeling, but they also address the conflated—and sometimes conflicted—forms of enthusiasm at the root of this tradition. After analyzing "My Own Character" (1818) and "Glimpses of My Life and Literary Character" (1820), the article reads Barrett’s first major volume of poetry, An Essay on Mind, with Other Poems (1826), as a logical extension of the principles found in these juvenile memoirs. As these texts show, Barrett's early poetics valued enthusiasm as necessary for writing poetry, and for establishing poetic identity.
Immersive Exhibition as Expanded Cinema: Augmenting Multisensory Experiences Through Responsive Atmosphere

This paper presents a multisensorial approach in the design and fabrication of an installation for “SEE-ING: The Environmental Consciousness Project”- a curated exhibition that brings together a diverse group of ten architects, artists, designers, technologies, and theorists across the global to look at how the transformed notion of vision, visual, or the visible nowadays inspires creative practices in a number of areas. To respond to the exhibition theme, the design takes the act of seeing as an incentive which elicits associated senses and exposes matters of the unseen. With 14 TV monitors in the gallery displaying moving images on the floor and the walls along with printed media, the exhibition is designed to be a comprehensive visual representation of featured contributions, and meanwhile, stitches the ten unique projects into a choreographed seeing experience through spatial and technological strategies that provoke senses beyond sight. This installation builds durational interfaces between human and the environment by visualizing data through physical computing and ephemeral mediums in order to generate physical spaces that trigger visual, tactile, and audial perceptions. It transitions the design of the “seen” into the construction of the “experience”. Situated in a contemporary exhibition setting, the paper discusses the creation of an immersive responsive atmosphere and its role in inviting human participation and interaction in various formats.
Domesticating the foreign body response: Recent advances and applications

The foreign body response is an immunological process that leads to the rejection of implanted devices and presents a fundamental challenge to their performance, durability, and therapeutic utility. Recent advances in materials development and device design are now providing strategies to overcome this immune-mediated reaction. Here, we briefly review our current mechanistic understanding of the foreign body response and highlight new anti-FBR technologies from this decade that have been applied successfully in biomedical applications relevant to implants, devices, and cell-based therapies. Further development of these important technologies promises to enable new therapies, diagnostics, and revolutionize the management of patient care for many intractable diseases.
Abstract C034: Cancer-specific intracellular delivery of therapeutic antibodies against RAS

Antibodies and peptides directed against the switch regions of RAS can disrupt interactions with its downstream effector proteins, blocking downstream protumorigenic signaling. However, these biologic therapies are unable to reach the intracellular environment. We have overcome this problem using peptidic molecular guidance system (MGSs) that have the unique ability to bind specifically to epithelial-derived cancer cells, and upon binding, trigger rapid internalization and trafficking to a specific subcellular location. Using an unbiased phage display approach, we have identified a series of cancer-specific MGSs that deliver cargo to discrete subcellular locations. Chemical optimization results in MGSs with 1-10 nM affinity for their cellular target, serum stability >48 hours, and 50- to 1000-fold specificity for cancer cells compared to normal control cells. The rate of MGS internalization is rapid with t1/2 of 10-30 minutes, achieving intracellular concentrations up to 1.5 μM. Using these MGSs as delivery agents, we have delivered a function-blocking RAS antibody (Y13-259), resulting in a reduction of p-ERK and apoptosis in KRAS mutant cell lines. The effect is MGS dependent, and confocal microscopy indicates co-localization of KRAS and the antibody indicating target engagement. The MGS-antibody homes to tumors in an animal model, resulting in significant suppression in tumor growth compared to untreated animals. Free MAb does not impact tumor growth. Using MGSs to delivery MAb for intracellular targets is a paradigm change for immunotherapy and represents a new approach for controlling intracellular protein-protein interactions. Combination of these cancer-specific delivery agents with effectors of RAS signaling, such as antibodies and other biologics, has therapeutic potential for KRAS-driven cancers. Citation Format: Michael J. McGuire, Susan Li, Indu Venugopal, Claire Gormley, Kevin J. Luebke, Curtis A. Allred, Kathlynn C. Brown. Cancer-specific intracellular delivery of therapeutic antibodies against KRAS [abstract]. In: Proceedings of the AACR Special Conference on Targeting RAS-Driven Cancers; 2018 Dec 9-12; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2020;18(5_Suppl):Abstract nr B21.
Responsibility to Protect goes to China: An interpretivist analysis of how China’s coexistence policy made it a Responsibility to Protect insider:

The article offers an interpretivist analysis of China’s coexistence approach to developing the Responsibility to Protect norm concerning atrocity crimes against civilians. The English school’s con...
With Wandering Steps and Slow: Schwellenkunst in Adalbert Stifter’s Granit

EnglishThis article explores what Walter Benjamin calls threshold images in Stifter’s tale, concrete objects or events that look both backwards and forwards, are allegorically infused with utopic fantasies, and nonetheless invite an awakening into history and change. The images are read for both their peculiar temporality and their allegorical poetics, and are pursued in their religious, psychological, and political dimensions before focusing on how they allegorize the work’s own aesthetic representational project through a staging of the medium-icity of language itself. The essay follows how Stifter’s language theory establishes the necessarily allegorical nature of realist representation that his aesthetic practice enacts, in ways that both ground and undermine the program of literary realism more generally. DeutschDieser Aufsatz untersucht »Schwellenbilder« in Stifters Erzahlung: laut Walter Benjamin konkrete, aber doch allegorische Gegenstande oder Ereignisse, die sowohl zuruck- als auch vorausweisen, mit utopischen Fantasien beladen sind und dennoch zum geschichtlichen Erwachen einladen. Die eigentumliche Temporalitat und die allegorische Poetik dieser Bilder werden herausgearbeitet, zunachst in Bezug auf ihre religiosen, psychologischen und politischen Dimensionen; danach in Bezug auf ihre Allegorisierung der im Text verwendeten Darstellungsweise bzw. der Medialitat von dessen Sprache. Der Aufsatz verfolgt, wie Stifters Sprachtheorie die notwendigerweise allegorische Beschaffenheit der Darstellungsweise etabliert, die nicht nur die Poetik dieser Erzahlung, sondern auch das allgemeine Programm des Realismus sowohl fundiert als auch untergrabt.
Embodied Intersectionalities of Urban Citizenship: Water, Infrastructure, and Gender in the Global South

Scholars have demonstrated that citizenship is tied to water provision in megacities of the Global South where water crises are extensive and the urban poor often do not have access to public water...
A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS EVALUATING RENAL DENERVATION FOR UNCONTROLLED AND RESISTANT HYPERTENSION

We systematically reviewed the literature to assess the comparative efficacy of treatment options for uncontrolled and resistant hypertension. Five engines were searched between 2010 and September 2019 for randomized controlled trials (RCTs) evaluating renal denervation with radiofrequency (RF) or
Functional Magnetic Resonance Imaging-Based Brain Computer Interfaces

Functional magnetic resonance imaging (fMRI) has been extensively used to study brain activity. With advances in signal processing, fMRI data can be analyzed in real time and used in a brain–computer interface (BCI). The feasibility and applications of an fMRI-based BCI (fMRI-BCI) have been studied with increasing frequency in the last decade. This chapter describes aspects of the fMRI-BCI technology and provides a thorough overview of the topic. We review the foundations of the fMRI-BCI, including the fundamental physics and physiology behind fMRI, present a qualitative introduction to relevant statistical analysis techniques, and discuss current applications including control of an external device and therapeutic neurofeedback techniques. Innovations in study design and neuroscience research will increase the suitability for fMRI-BCI to be integrated into clinical methods.
Tip-enhanced Raman spectroscopy and microscopy in the atomistic near-field

Tip-enhanced Raman spectroscopy and microscopy are performed on a single nitrogen atom, carbon monoxide, pyridine, and benzene adsorbed on the Cu(100) surface. As the complexity of system ranging from an atomic vibrator to polyatomic molecules increases, the collective information gained from individual experiments elucidates the governing mechanism of Raman scattering in the atomistic near-field from different angles. Rich physics observed from above-mentioned systems such as dielectric screening, concomitant electromagnetic and chemical enhancement, Stark shift, dehydrogenation, and distortion and recovery of vibrational information will be discussed.
Association Between Knee- and Hip-Extensor Strength and Running-Related Injury Biomechanics in Collegiate Distance Runners

Context Running-related injuries are common in distance runners. Strength training is used for performance enhancement and injury prevention. However, the association between maximal strength and distance-running biomechanics is unclear. Objective To determine the relationship between maximal knee- and hip-extensor strength and running biomechanics previously associated with injury risk. Design Cross-sectional study. Setting Research laboratory. Patients or other participants A total of 36 collegiate distance runners (26 men, 10 women; age = 20.0 ± 1.5 years, height = 1.74 ± 0.09 m, mass = 61.97 ± 8.26 kg). Main outcome measure(s) Strength was assessed using the 1-repetition maximum (1RM) back squat and maximal voluntary isometric contractions of the knee extensors and hip extensors. Three-dimensional running biomechanics were assessed overground at a self-selected speed. Running variables were the peak instantaneous vertical loading rate; peak forward trunk-lean angle; knee-flexion, internal-rotation, and -abduction angles and internal moments; and hip-extension, internal-rotation, and -adduction angles and internal moments. Separate stepwise linear regression models were used to examine the associations between strength and biomechanical outcomes (ΔR2) after accounting for sex, running speed, and foot-strike index. Results Greater 1RM back-squat strength was associated with a larger peak knee-flexion angle (ΔR2 = 0.110, ΔP = .045) and smaller peak knee internal-rotation angle (ΔR2 = 0.127, ΔP = .03) and internal-rotation moment (ΔR2 = 0.129, ΔP = .03) after accounting for sex, speed, and foot-strike index. No associations were found between 1RM back-squat strength and hip kinematics or kinetics, trunk lean, or vertical loading rate. Hip- and knee-extensor maximal voluntary isometric contractions were also not associated with any biomechanical variables. Conclusions Greater 1RM back-squat strength was weakly associated with a larger peak knee-flexion angle and smaller knee internal-rotation angle and moment in collegiate distance runners. Runners who are weaker in the back-squat exercise may exhibit running biomechanics associated with the development of knee-related injuries.
Right transradial coronary angiography in the setting of tortuous brachiocephalic/thoracic aorta ("elephant head"): Impact on fluoroscopy time and contrast use

Objectives Assess the impact on fluoroscopy time and contrast use in patients with tortuous brachiocephalic/thoracic aortas undergoing right transradial coronary angiography (RTCA) and provide strategies to manage. Background Unfavorable anatomy with severe brachiocephalic/thoracic tortuosity, referred to as an "elephant head," remains a significant obstacle for RTCA. Methods We reviewed the coronary angiograms of patients who underwent RTCA and had tortuous aortas. Angiography was attempted first using a universal catheter (Tiger) and switched to a left coronary specific catheter (Judkins Left [JL]) if challenging. Fluoroscopy time, contrast volume, and greatest distance from the patient's midline to the catheter in the aorta were recorded. Results Forty-nine patients (62.6 ± 12.0 years, 69.4% male) were included. Fifteen (30.6%) patients underwent successful angiography with a Tiger catheter; 34 (69.4%) patients required switching to JL catheter. The average distance of Tiger catheters to the midline of the spine was 0.78 ± 0.41 cm versus 1.28 ± 0.44 cm (p = .001) in JL catheters. Tiger catheter use resulted in less fluoroscopy time (6.48 ± 4.73 min) and contrast use (58.87 ± 43.53 ml) than in cases switched to JL (13.26 ± 10.76 min [p = .026]; 86.5 ± 69.95 ml [(p = .017]). Conclusions For patients undergoing RTCA with significant brachiocephalic/thoracic aorta tortuosity, "elephant head," a Tiger catheter can be used efficiently for curvatures 1 cm, operators should consider immediately switching to a JL catheter.