cssi/SciSciGPT-SciSciNet huggingface dataset:
HER-2/neu-Positive breast carcinoma: molecular concomitants by proteomic analysis and their therapeutic implications.

Objective: To identify molecular events that occur concomitantly in HER-2/neu protein-receptor- positive breast carcinoma and to identify pathogenetic and growth-modulating sequences around its tyrosine- kinase-mediated cell proliferation and tumorigenesis that may be amenable to therapeutic interventions. Methods: Slides containing sections of 3 pelleted human breast carcinoma cell lines (DAKO HercepTest) and expressing HER-2/neu protein-receptor scored at 3+ (SKBR-3), 1+ (MDA-175), and 0 (MDA-231), respectively, were reacted in immunohistochemical procedures for the detection of the following antigens: HER-2, estrogen receptor (ER), progesterone receptor (PR), Ki-67, cyclin D1, c-Jun, epidermal growth factor receptor (EGFR), transforming growth factor (TGF)-α, components of the JAK/STAT signal transduction pathway (gp130, interleukin (IL)-6, and IL-11), p21ras, farnesyl transferase (FT), and potential growth inhibitory/proapoptotic and antiapoptotic-related proteins (latency-associated peptide (LAP) of TGF-β1, TGF-β receptor (R) II, p53, and bcl-2 and cyclooxygenase (COX)-2). Immunoreactivities were graded using bright-field microscopy on a scale of 0 to 3+. Results: Commonalities noted among the 3 cell lines include absent (0) chromogenic signals for ER and PR, relatively high Ki-67 proliferation indices (54, 40, and 61%, respectively), and positive signals (1 to 3+) for IL-6, IL-11, TGF-α, EGFR, TGF-β1 (LAP), TGF-βRII,FT, p21ras, and p53. Strong intranuclear immunopositivities for cyclin D1 and c-Jun antigens were evident in the MDA-231 cell line but absent or rare (0 to ±) in SKBR-3. Conversely, gp130 antigen was readily detected in the SKBR-3 cell line but only weakly expressed (±) in MDA-231, whereas bcl-2 and COX-2 were expressed in the latter and not in SKBR-3 cells. Conclusions: These data suggest that signal transduction through farnesylated p21ras is part of the pathogenesis of tyrosine-kinase-mediated proliferation in HER-2/neu protein-receptor-positive breast carcinoma. Collaborations with the EGFR and JAK/STAT systems in these molecular events are also likely. Potential therapeutic agents include downregulators of c-erb-B1 (EGFR) and -B2 (HER-2) receptor expressions, inhibitors of tyrosine kinase and farnesylation, and activators of growth inhibitory/proapoptotic pathways. (received 3 August 2001, accepted 21 September 2001)
No Child Left Unharmed: The Image of the Child in The Hunger Games

This project seeks to examine the role of the child presented in The Hunger Games by comparing the image of the child to that of the adult, both in the individual districts and in the utopian city of the Capital. By using the contrasting images, I aim to show how imagery is used to draw on the significance of the misplaced roles. Director Gary Ross uses opposing color themes to show stark differences between the Capital and the districts. However, I feel that a further argument can be made in the way that the children and adults are expressed on screen. The image of the child is important to look at in this film, because of how the Capital uses children—both their image on screen and by tools within this society—to manipulate the power within the dystopian city of Panem.
Modeling of Jet Noise Sources and their Diffraction with Uniform Flow

A methodology is presented for treating the propagation of elementary jet noise sources in the presence of a uniform mean flow. The sources include wavepacket and point sources, and the propagation includes the diffraction around solid boundaries. The governing equations are reduced to the canonical wave equation through established transformations. The impact of the transformations on the wavepacket and point sources is discussed, with attention on the distinction between sources of pressure and sources of volume. The coupling of the transformations with the boundary element method, for the prediction of diffraction, is outlined. The impact of uniform flow on the emission of an acoustic monopole produces a complicated pressure field with different near- and and far-field scaling laws. The principal effect of flight speed on the wavepacket emission is to shift the range of radiating axial wavenumbers, resulting in attenuation and re-direction of the acoustic emission. For both the wavepacket and monopole, the flight Mach number causes a compaction of the acoustic field downstream of the source, a trend that benefits the shielding of those sources.
Family physical activity and meal practices associated with disordered weight control behaviors in a multiethnic sample of middle-school youth

Abstract Objective Family practices around weight-related behaviors can shape children's development of disordered weight control behaviors (DWCB), such as vomiting, taking laxatives, or taking diet pills without a prescription. This study examined family meal and physical activity (PA) practices associated with DWCB among a multiethnic sample of youth. Methods We assessed self-report data on frequency of family sit-down dinners, types of parental involvement in their children's PA, and DWCB are from 15,461 6th to 8th grade girls and boys in 47 middle schools participating in the Massachusetts Healthy Choices Study at baseline (2005). Results Youth who had family sit-down dinners every day had lower odds of DWCB (girls: odds ratio [OR] 0.3; 95% confidence interval [CI] 0.2–0.5; boys: OR 0.6; 95% CI 0.4–0.9) than youth who never had family sit-down dinners. Similar effect estimates were found for youth who had family sit-down dinners most days. Parental provision of rides to and from a PA event was also found to be protective against DWCB among girls (OR 0.7; 95% CI 0.5–0.9). In contrast, parental participation in PA with their children was associated with increased risk for DWCB (girls: OR 1.4; 95% CI 1.0–1.8; boys: OR 1.9; 95% CI 1.4–2.4). These associations did not differ by race/ethnicity or weight status. Conclusions Programs emphasizing the importance of family meals may be beneficial in preventing DWCB in youth of all ethnicities. Further research is needed on how various methods of parental involvement in their children's PA are associated with DWCB.
5-HTTLPR short allele, resilience, and successful aging in older adults.

Objective Resilience is proposed as a significant component of successful aging. Young adult carriers of the Serotonin Transporter Polymorphism (5-HTTLPR) short(s) allele appear to have reduced resilience to stress. We examined whether the presence of the short allele was associated with poorer emotional resilience in older adults. Methods In a cross-sectional study of 99 healthy, community-dwelling, older adults, we determined 5-HTTLPR genotype status and administered the Connor-Davidson Resilience Scale and self-reported measures of successful aging, cognition, and health. Results There was no significant association between the 5-HTTLPR s allele and resilience. S allele carriers had worse cognition and self-report ratings of successful aging. Conclusion These findings suggest that the impact of the 5-HTTLPR s allele on stress-related outcomes may attenuate with older age. However, s allele status appears to be a biomarker of poorer self-rated successful aging, and cognitive performance in older adults.
Linezolid Therapy of Staphylococcus aureus Experimental Osteomyelitis

The in vivo activity of linezolid or cefazolin against a clinical isolate of methicillin-susceptible Staphylococcus aureus (linezolid MIC, 2 μg/ml) was studied in a rat model of experimental osteomyelitis. Sixty rats with experimental S. aureus osteomyelitis were treated for 21 days with no antimicrobial, with 25 μg of linezolid per kg of body weight administered intraperitoneally twice or three times a day, or with 50 μg of cefazolin per kg administered intramuscularly three times a day. After treatment, the animals were sacrificed and the infected tibiae were processed for quantitative bacterial cultures. The results of treatment were expressed as log10 CFU/gram of bone and analyzed by rank sum analysis. The results of linezolid treatment were not significantly different from those of untreated controls, while cefazolin treatment was significantly more active than no treatment or linezolid treatment.
Radiative Penguin Decays of B Mesons: Measurements of B → K*γ, $B \to K^*_2(1430)\gamma$, and Search for B0 → ϕγ

Electromagnetic radiative penguin decays of the B meson were studied with the BABAR detector at SLAC's PEP-II asymmetric-energy B Factory. Branching fractions and isospin asymmetry of the decay B → K*γ, branching fractions of , and a search for B0 → ϕγ are presented. The decay rates may be enhanced by contributions from non-standard model processes.
Carrier Transport and Velocity Overshoot in Strained Si On Sige Heterostructures

We examine the velocity overshoot effect in strained Six on Six-Ge1-x heterostructures. We also investigate the performance of surface-channel strained-Si MOSFETs for devices with gate lengths representative of the state-of-the-art technology. The Ensemble Monte Carlo method, self-consistently coupled with the 2D Poisson equation solver, is used in the investigation of the device performance. Our simulations suggest that, in short-channel devices, velocity overshoot is very important. In fact, when velocity overshoot occurs, it greatly affects the carrier dynamics and the current enhancement factor of both surface-channel strained-Si and conventional Si MOSFETs.
The Rotation Curve of Simulated and Real Galaxies

We discuss the accuracy for the recovery of mass profiles in simulated dwarf galaxies. We also present cosmologically motivated, high resolution N -body models for two nearby dwarf galaxies: NGC 3109 and NGC 6822. The rotation curves in our models are measured using standard observational techniques, projecting velocities along the line of sight of an artificial observer and performing a tilted ring analysis. Our models reproduce the rotation curves of both galaxies, the disk surface brightness profiles as well as the profile of isophotal ellipticity and position angle. We show that non-circular motions combined with gas pressure support and projection effects systematically underestimate by up to 50% the rotation velocity of cold gas in the central ~1 kpc region, creating the illusion of a constant density core.
Diffusional Creep and Cavitational Strains in High‐Purity Alumina under Tension and Subsequent Hydrostatic Compression

Diffusional creep and cavitation in pure alumina prepared with three different fabrication processes are compared under tension and subsequent hydrostatic compression. The deformation rates are separated into a volume-conserving creep rate and cavitational rate by measuring the longitudinal and transverse strains intermittently during deformation. Concurrent grain growth causes the volume-conserving strain rate to decrease in a manner consistent with Nabarro-Herring creep. The creep stress index of n= 1.3 and the average activation energy of Q= 480 kJ/mol are also consistent with Nabarro-Herring creep controlled by aluminum lattice diffusion. Anelastic loading and unloading transients are also identified and separated from the creep strains. High-voltage electron microscopy indicates that cavities nucleate at grain edges early and continuously in the creep process. The surfaces of these cavities tend after some growth to exhibit negligible curvature and various dihedral angles. The activation energy of Q= 450 kJ/mol and stress dependence of the cavitation rate of n= 1.3 are consistent with a grain boundary diffusional growth mechanism. The loading mode is found to have no significant effect on the cavitation rate during tensile creep and the subsequent decavitation rate during hydrostatic compression. The cavitation and decavitation rates are in good agreement with the model proposed by Speight and Beere when the effects of grain growth on cavity accumulation on grain boundaries are included. Exaggerated grain growth in high-density specimens can lead to early cavity coalescence and failure.
Trust-Based Cooperative Action Control in Multi-agent Systems for Network Management

A mechanism to control cooperative actions in multi-agent systems for network management systems that consists of agents managed by different network management authorities (NMAs), such as ISPs and universities, is presented. In spite of cooperative work among NMAs being indispensable for Internet management, NMAs do not always trust or coordinate with each other because their intentions or policies may conflict. Therefore, in actual cases, cooperative work among NMAs is controlled with regard to the trustworthiness of the NMAs. Cooperative actions with no control may cause security problems, such as unintentional disclosure of network information. When a multi-agent system is deployed for network management, cooperative actions between agents must also be controlled in the same way as in actual network management. To achieve such control, our mechanism focuses on the trustworthiness of NMAs and controls cooperative actions on the basis of two parameters: 1) agent attributes and 2) reliability values. These parameters are referred or exchanged among the agents on an on-demand basis, and on their basis,the agents determine the availability of information of concern. Experimental results suggest that a network management system combined with our mechanism appropriately controls cooperative actions. These results demonstrate the feasibility of our basic design.
Improving medication-related outcomes for patients with psychiatric and neurologic disorders: Value of psychiatric pharmacists as part of the health care team

Psychiatric pharmacists have specialized knowledge, skills, and training or substantial experience working with patients with psychiatric or neurologic disorders. As part of the collaborative team with a physician, psychiatric pharmacists can provide comprehensive medication management (CMM), a direct patient care service, to patients with psychiatric or neurologic disorders. CMM is a standard of care in which all medications for an individual patient are assessed to determine appropriateness, effectiveness, safety, and adherence. Studies have shown that when psychiatric pharmacists are included as part of the collaborative team with a physician, medication-related outcomes for patients with psychiatric or neurologic disorders improve. Despite the evidence supporting the value of psychiatric pharmacists as part of the health care team, the very limited mechanisms for compensation for CMM limit the numbers of patients with psychiatric or neurologic disorders who have access to services provided by a psychi...
We Must Rescue Them

KIE: Leber describes the motivation and goals of Operation Rescue, a pro-life activist organization. Arguing that all human life is sacred from the moment of conception until natural death, Leber blames the acceptance of abortion on the values of an affluent society. He finds justification for Operation Rescue's work in the Old and New Testaments, and calls for acceptance of biblical standards of ethics and morals in rejecting abortion.
Intellectual and Physical Disabilities in Prehistory and Early Civilization

This paper is focused on three basic questions: The first concerns when specific disabilities first appeared during human evolution. The second question has to do with causes of disabilities. The third question concerns social responses to people with disabilities. Discussions on each of the issues are presented.
Establishing therapeutic rapport in telemental health.

Concepts of rapport and therapeutic alliance have been found to be robust predictors of treatment response and can be impacted by technology found in telemental health. This chapter reviews the relevant research on rapport and the concepts of therapeutic alliance as they impact telemental health and discusses practical considerations impacting technology choices, such as technology that allows sufficient bandwidth for fluid transmissions and detailed observations of patients. Careful consideration of rapport within the context of individual interactions, relationships with local clinicians, and communities at large are also discussed. The focus is on a practical understanding of rapport with concrete recommendations to develop relationships within the telemental health setting.
Development and Testing of the Combined Assessment of Psychiatric Environments: A Patient-Centered Quality Measure for Inpatient Psychiatric Treatment

BACKGROUND: Inpatient psychiatric treatment satisfaction measures are not constructed from patients’ perspective of hospitalization experiences that they deem meaningful and important. OBJECTIVE: To develop and conduct psychometric testing of a measure that evaluates person-centered care on inpatient psychiatric units, the Combined Assessment of Psychiatric Environments (CAPE). The measure is built on a theoretical framework holding that if optimal care is to be achieved, all major stakeholders (patients and staff) need to experience a positive environment. DESIGN: An instrument development design was used to create the patient/staff nurse versions of the CAPE and to test their dimensions. The pilot versions of the CAPE were tested on six inpatient psychiatric units to determine the psychometrics of the staff/patient versions. RESULTS: The overall reliability of both versions of the CAPE (staff/patient) was .91. The test–retest reliability for both versions was significant at the .01 level. Construct vali...
Paper chromatographic determination of trimethyloctadecyl quaternary ammonium chloride in dimethyldioctadecyl quaternary ammonium chloride

A quantitative paper chromatographic method was worked out for determining small amounts of trimethyloctadecyl quaternary ammonium chloride in dimethyldioctadecyl quaternary ammonium chloride. With a mixed solvent containing methanol, acetone, and water, the trimethyl-type quaternary travels just behind the solvent front, whereas the dimethyl-type quaternary and other components move very little. The trimethyl quaternary spot is developed with bromphenol blue and the resulting color is measured photometrically at 607 mμ. Standards are run on either side of the sample spot and are used for quantitative calibration. Accuracy and reproducibility of the method appears to be within 0.4% absolute.
Configuration Synthesis in Multidimensional Scaling

This article illustrates how separate data sets or scaling solutions can be synthesized to develop “master” configurations that summarize communalities among separate solutions. The procedure is il...
Genetic and environmental parameters for traits derived from the Brody growth curve and their relationships with weaning weight in Angus cattle

Direct and maternal genetic and environmental variances and covariances were estimated for weaning weight and growth and maturing traits derived from the Brody growth curve. Data consisted of field records of weight measurements of 3,044 Angus cows and 29,943 weaning weight records of both sexes. Growth traits included weights and growth rates at 365 and 550 d, respectively. Maturing traits included the age of animals when they reached 65% of mature weight, relative growth rates, and degrees of maturity at 365 and 550 d. Variance and covariance components were estimated by REML from a set of two-trait animal models including weaning weight paired with a growth or maturing trait. Weaning and cow contemporary groups were defined as fixed effects. Random effects for weaning weight included direct genetic, maternal genetic, and permanent environmental effects. For growth and maturing traits, a random direct genetic effect was included in the model. Direct heritability estimates for growth traits ranged from .46 to .52 and for maturing traits from .31 to .34. Direct genetic correlations between weaning weight and weights and growth rates at 365 and 550 d ranged from .56 to .70. Correlations of maternal weaning genetic effects with direct genetic effects on weights at 365 and 550 d were positive, but those with growth rates were negative. Between weaning weight and degrees of maturity at both 365 and 550 d, direct genetic correlation estimates were .55 and maternal genetic correlations estimates were -.05, respectively. Direct genetic correlations of weaning weight with relative growth rates and age at 65% of mature weight ranged from .04 to .06, and maternal-direct genetic correlation estimates ranged from -.50 to -.56, respectively. These estimates indicate that higher genetic capacity for milk production was related to higher body mass and degrees of maturity between 365 and 550 d of age but was negatively related to absolute and relative growth rates in that life stage.
Additive main effect and multiplicative interaction analysis of national turfgrass performance trials: II. Cultivar recommendations

A parsimonious additive main effect and multiplicative interaction (AMMI) model has often been shown to be more accurate than the cell means from which it is computed in predicting future performance, especially where complex genotype x environment (GE) interactions exist, as is typical of National Turfgrass Evaluation Program (NTEP) variety trials. NTEP relies on ANOVA procedures for estimates (means averaged over replicates) to predict turfgrass quality performance. The objectives of this research were (i) to compare the predictive accuracy and statistical efficiency of AMMI models relative to the cell means model (means averaged over replicates or AMMI-F full model) and (ii) using mega-environment analysis of AMMI, identify subregions within the cool-season turfgrass growing region having similar GE interaction patterns and cultivar recommendations. The 1990 Kentucky bluegrass (Poa pratensis L.) and perennial ryegrass (Lolium perenne L.) variety trials were analyzed. The GE interactions in Kentucky bluegrass (KBG) and perennial ryegrass (PRG) data sets contain 33.3 and 40.6% noise, respectively. Noise complicates cultivar recommendations and AMMI was shown to recover noise selectively in a discarded residual. Based on validation studies, AMMI reduced models (AMMI-2 for PRG and AMMI-7 for KBG) were shown to be more predictively accurate with a statistical efficiency relative to AMMI-F of 2.05 (KBG) and 5.6 (PRG). Mega-environment analysis identified several subregions, each representing several NTEP locations. Mega-environments follow a cultural intensity gradient that can be altered by mowing height and nitrogen fertilization. Locations from the same subregion had better predictive value for other locations from the same subregion. This may allow the same genotypes to be targeted to all locations from the same subregion, simplifying cultivar recommendations. The data suggest that if the goal is to recommend the most reliable genotype, then priority should be given to AMMI adjusted means.
Electronic “Ambassador”: The Diplomatic Missions of IBM’s RAMAC 305

This paper traces the “diplomatic missions” of the RAMAC 305 developed by IBM in California during the late 1950s and instrumentalized as an “animate” ambassador of American computing technology abroad. Specifically, this paper looks at IBM’s exhibit at the American National Exhibition in Moscow (July 1959) and Nikita Khrushchev’s tour to the IBM manufacturing plant in San Jose, California (September 1959) to argue that the RAMAC 305 was envisioned and designed as a modular system of combinable units and peripherals that could be easily—and quite literally—transferred around the world. Ultimately, this work demonstrates how the carefully choreographed exhibiting of Western computing power by American companies like IBM actively accelerated the participation of USSR in global treatises on the fair use of patented information technologies in the decades that followed.
Hemophilia Treatment - A Model for Appropriate Cost Control.

Hemophilia patients consume large quantities of biologicals. Many are on prophylactic regimens which cost substantially more and have better outcomes as compared to on-demand treatment. In either situation, 95% of costs of care are biologics. As costs are high, third-party payers frequently challenge various treatment regimens. Aetna Inc., working with nurses and a hemophilia treater, initiated a systematic evaluation program of 400 members with hemophilia enrolled in HMO plans to investigate whether these costs could be appropriately controlled. Several caveats were agreed to: No therapeutic modality would be changed unless medically indicated. Patients would be supported to have an annual visit to a comprehensive center, if they were not already followed by one. Changes where biologics were purchased were only done with physician and client agreement. Over the past three years, substantial savings have been accomplished PMPM (per member / per month fully-insured HMO member). The savings were attributable, in the main, to simply shifting how and where biologics were purchased and could not have been accomplished without the federal PHS pricing program. In three years’ time, annual savings per patient were substantial. The savings per subscriber encouraged Aetna, Inc. to continue this program.
Abstract TP110: Polymerase δ-Interacting Protein 2 Regulates Astrocyte Activation in Ischemic Stroke

Introduction: Polymerase δ-Interacting Protein 2 (Poldip2) is a binding partner of Nox4 NADPH oxidase and carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). Nox4 and CEACAM1 have been implicated in stroke, but with different outcomes: both contribute to neurodegeneration but only CEACAM1 contributes to blood brain barrier (BBB) dysfunction. However, the underlying mechanisms are still obscure. Hypothesis: Poldip2+/- mice may be protected from the consequences of transient middle cerebral artery occlusion (tMCAO). Methods: tMCAO was induced in wild type (WT) and Poldip2+/- mice. The volume of the ischemic lesion was measured in TTC-stained sections. BBB breakdown was evaluated by Evans blue dye extravasation. Poldip2 protein expression was evaluated by immunofluorescence and western blotting. RT-PCR was used to measure mRNA levels of cytokines, MMPs and TIMPs. Astrocytes were transfected with Poldip2 siRNA in culture and mRNA levels of cytokines were evaluated. Results: Poldip2+/- and WT mice displayed comparable infarct sizes following tMCAO (n=6). A decrease in Evans blue dye extravasation was observed in Poldip2+/- mice (25±3 vs 6±2uM/g) (n=7). Upregulation of cytokine mRNA following tMCAO was also attenuated in Poldip2+/- mice (n=5): MCP-1(253±34 vs 83±23AU), IL-6 (134±38 vs 38±10AU), TNFα (39±12 vs 12±3AU), MMP-2 (19±3 vs 10±1AU), MMP-9 (253±12 vs 13±3AU) and TIMP-1 (286±110 vs 61±15AU). Poldip2 protein expression increased in the ischemic brain of WT mice after tMCAO (69±4 vs 20±5AU) and was predominantly located in astrocytes (n=4). Poldip2 protein expression was also increased in astrocytes following oxygen and glucose deprivation (79±15 vs 27±5AU) (n=6), and Poldip2 siRNA prevented cytokine induction under these conditions. Conclusions: In conclusion, Poldip2 contributes to stroke-induced BBB breakdown via its ability to inhibit a pro- inflammatory response in perivascular astrocytes.
The Structure of Medical Intensive Care Units at Training Institutions.

Abstract Background As a result of the 2011 Accreditation Council for Graduate Medical Education (ACGME) work hour guideline implementation, the structure of intensive care unit (ICU) teams at training institutions has been affected. The impact these changes have had on the current work environment has not been well described. Methods The authors conducted an online survey of internal medicine program directors in 2016. The survey investigated how training institutions structure their intensive care units in reference to volume, resident housestaff and alternative coverage options, with a focus on changes made after the implementation of the 2011 ACGME duty hour restrictions. Results Notable differences were found in program director responses to coverage of patients in the ICUs. A total of 62 of the 132 (48%) responding program directors describe coverage of all patients solely by resident housestaff. Since 2011, 54 (41%) programs have increased the number of resident physicians rotating in the ICU per month and initiated or increased the use of nonresident coverage of patients. Use of non-resident providers is not associated with a decrease in the number of total ICU months per resident or a decrease in educational value. Conclusions Since the 2011 ACGME duty hour implementation, there is wide variability in the learning environment of medical intensive care units in training institutions.
The phosphatidic acid-binding, polybasic domain is responsible for the differences in the phosphoregulation of lipins 1 and 3.

Lipins 1, 2, and 3 are Mg2+-dependent phosphatidic acid phosphatases and catalyze the penultimate step of triacylglycerol synthesis. We have previously investigated the biochemistry of lipins 1 and 2 and shown that di-anionic phosphatidic acid (PA) augments their activity and lipid binding and that lipin 1 activity is negatively regulated by phosphorylation. In the present study, we show that phosphorylation does not affect the catalytic activity of lipin 3 or its ability to associate with PA in vitro. The lipin proteins each contain a conserved polybasic domain (PBD) composed of nine lysine and arginine residues located between the conserved N- and C-terminal domains. In lipin 1, the PBD is the site of PA binding and sensing of the PA electrostatic charge. The specific arrangement and number of the lysines and arginines of the PBD vary among the lipins. We show that the different PBDs of lipins 1 and 3 are responsible for the presence of phosphoregulation on the former but not the latter enzyme. To do so, we generated lipin 1 that contained the PBD of lipin 3 and vice versa. The lipin 1 enzyme with the lipin 3 PBD lost its ability to be regulated by phosphorylation but remained downstream of phosphorylation by mammalian target of rapamycin. Conversely, the presence of the lipin 1 PBD in lipin 3 subjected the enzyme to negative intramolecular control by phosphorylation. These results indicate a mechanism for the observed differences in lipin phosphoregulation in vitro.
Medullary Thyroid Cancer: Overview and Case Study of a Rare Cancer

Background Medullary thyroid cancer (MTC) is a rare cancer that has historically been managed by endocrinologists. In 2011, the first of several multi- targeted tyrosine kinase inhibitors was approved as treatment for MTC. These drugs have changed the management of MTC to teams that include oncologists and oncology nurses. Objectives This article illustrates MTC diagnostics, surveillance, management of adverse drug reactions, and disease progression through a case study. Methods An overview of MTC is offered, followed by an in-depth case study that examines MTC from the patient's perspective. Findings Oncology nurses can influence patient outcomes through the provision of patient education, support, and management of disease and treatment complications.
Evaluation of a novel, low-cost plastic solar air heater for turkey brooding

Abstract Solar heat could displace fossil fuel to reduce energy cost for brooding livestock and poultry. A transpired solar collector (TSC), consisting of a perforated dark-colored metal surface, can provide considerable heating but metal TSCs (mTSCs) are expensive. Since a perforated black plastic sheet will be less-expensive, a plastic TSC (pTSC) was evaluated. The 1.49 m2 pTSC (porosity of 1.2%) supplemented a propane heater in a room housing 240 turkey poults; an adjacent room without a pTSC, with 240 poults was the control. Monitoring was performed over two flocks of poults. A custom-built controller bypassed the pTSC during nighttime or when the room did not require heating to bring in fresh air. The pTSC gave a maximum temperature rise of 25.4 °C at a solar irradiance (I) of 882 W/m2 and suction velocity (Vs) of 0.033 m/s over 15 min. Over 178 h of operation, with an average I of 668 ± 295 W/m2 and average Vs of 0.036 m/s, the pTSC increased air temperature by an average of 8.1 ± 4.2 °C. Probably due to higher ventilation rate and an oversized propane heater, propane use was not reduced in the Test room with the pTSC vs. the Control room. The Test room had lower CO2 and CO concentrations due to higher ventilation, which may have improved turkey performance. The metal TSC gave a slightly higher temperature rise at a lower Vs but the less-expensive pTSC could be a more cost-effective solar air heater that could readily be scaled up for agricultural and other applications in many parts of the world. Scale-up considerations seem feasible and are presented for a 10,000-poult brooder barn.
Biomineralization and Tentative Links to Plate Tectonics

Tectonic processes appear to be a principal forcing function controlling some aspects of the sedimentary cycling of materials during the geologic past. Chemical trends observed in the sedimentary rock record for the past 80 Ma substantiate the hypothesis that plate tectonics play a major role in influencing, on a long-time scale, several variables of ocean-atmosphere-sediment chemistry. The apparent long-term decrease in sea level since the Late Cretaceous (80 Ma) was probably caused by a global decrease in sea-floor spreading rate and ridge volume. This waning of tectonic activity may have resulted in reduced volcanic and diagenetic-metamorphic CO2 release to the earth’s surface environment, giving rise to lower atmospheric CO2 level and temperatures. The carbonate saturation state and the Mg/Ca, Sr/Ca, Na/Ca, 87Sr/86Sr, and 143Nd/144Nd ratios of sea water may have progressively increased during the sea level fall. It is postulated that the global environmental response to increased tectonic activity probably is opposite to that proposed for the past 80 Ma.
CALCIUM-DEPENDENT LINKS IN STIMULUS-SECRETION COUPLING IN THE ADRENAL MEDULLA AND NEUROHYPOPHYSIS

Publisher Summary This chapter describes calcium-dependent links in stimulus–secretion coupling in the adrenal medulla and neurohypophysis. The chromaffin cells of the adrenal medulla are known to be innervated by secretomotor nerves that are cholinergic. Acetylcholine is, thus, the immediate physiological stimulus that causes the chromaffin cells to release their hormones, adrenaline, and noradrenaline, into the blood stream. In the presence of 56 mM potassium, it was found that Ca++ uptake in the medulla was enormously increased. This was encouraging because there was already evidence that excess potassium has a direct stimulant action on the medullary chromaffin cells. It was also found that potassium, like ACh, stimulated catecholamine secretion only when calcium was present in the external environment, and further, that the response to potassium became increasingly great as the concentration of calcium in the extracellular medium was increased. The most probable explanation of the stimulant effect of excess potassium was, therefore, the consequence of membrane depolarization resulting from a diminution the ratio of K inside to K outside the membrane.
Restatements and Non-State Codifications of Private Law

This paper offers a vantage point through which to assess the phenomenon of projects codifying private law that are undertaken by private persons or institutions, distinct from legislatures and state-sponsored codification and law-revision projects. The private institution on which this paper focuses is the American Law Institute (ALI). ALI works in statutory form—most notably the Uniform Commercial Code and the Model Penal Code—as well as through projects that generate “Principles” to guide legal development within their specific fields and “Restatements” that authoritatively cover the law in a field.
Clavicular osteotomy and internal rigid fixation to the super extended pectoralis major musculocutaneous flap.

Technique de reconstruction immediate apres exerese des lesions malignes de la tete et du cou
Protection of Keratinous Materials with Synthetic Pyrethroid Insecticides

Deterioration of wool by insects dates back to antiquity. It is unusual to find woolen textiles at prehistoric sites. Woolen items are rarely found at archeological sites because wool is so prone to deterioration by insects and microorganisms. Conversely, fabrics like linen have survived from times more remote because it is not susceptible to insect and/or other deterioration.
Negative Pressure Wound Therapy (Wound VAC) in the Treatment of Chylous Fistula After Neck Dissection

Objectives:Cervical chylous fistula is an uncommon but potentially severe occurrence associated with neck surgery. Methods for treating this problem have inconsistent efficacy and may result in len...
Disease characteristics and treatment outcomes of young colorectal cancer patients.

691Background: The incidence of colorectal cancer (CRC) in young patients (< 50 years) is increasing but little is known about disease characteristics and treatment outcomes in this patient populat...
A Review of Self-Control Treatments for Aggressive Behavior

Self-control procedures have recently been applied in numerous settings to a number of learning and behavior problems. Treatment of acting-out and aggressive behaviors, an area that is a major conc...
Prevalence and concentration of stx+ E. coli and E. coli O157 in bovine manure from Florida farms

Fresh produce outbreaks due to Shiga toxin-producing Escherichia coli (STEC) continue to occur in the United States (US). Manure-amended soils can pose a public health risk when used for growing raw agricultural commodities. Knowing the prevalence and concentration of STEC in untreated biological soil amendments of animal origin (BSAAO) is important to help guide the most appropriate pre-harvest interval(s) following application to limit risks from these soil amendments. Bovine manure samples were collected from 12 farms in Florida, including samples from piles, lagoons, barns, and screened solids. Two methods were used to detect stx1/2 and rfbE genes in samples. A prevalence rate of 9% for stx1 and/or stx2 and 19% for rfbE was observed from the 518 bovine manure samples evaluated. A most probable number (MPN) assay was performed on stx+ samples when applicable. The geometric mean for stx+ samples (n = 20) was 3.37 MPN g-1 (0.53 log MPN g-1) with a maximum value of 6,800 MPN g-1 (3.83 log MPN g-1). This research was part of a larger nationwide geographical study on the prevalence and concentration of STEC in bovine manure to help guide regulations on feasible pre-harvest intervals for the application of untreated BSAAO.
Issues in the Design of Marine Vehicles A Needs Based Analysis

Over the last two and a half decades, the design of both Autonomous Underwater Vehicles (AUVs) and Autonomous Surface Vessels have matured considerably as the original academic and commercial designs have been deployed in the field. In the case of AUVs, the designs typically came from the scientific community based on fundamental theoretical principles that, in most cases, were well understood and easy to formulate. Numerous companies now provide off the shelf solutions across a variety of scales and application areas. Most of the offerings are very similar with torpedo shaped vehicles and depth ratings that are standard in the ranges 100m, 1500m3000m, and 4500-6000m. In this paper we look instead at some of the evolving designs and challenges facing the AUV/ASV technologies. Some of these challenges such as docking have been around for two and a half decades. Other challenges include the disruptive forces associated with technologies such as hobby electronics and IoT (the internet ofthings). The focus of this paper is to look at a number of examples of AUVs and ASVs that are typically nontraditional in terms of their design and how they evolved to fit their respective niches. Examples of such concepts include the original ABE, Seabed and Sentry vehicles at WHOI and the hybrid AUV/ROV technologies that were also pioneered there. We extend our analysis to look at Autonomous Surface Vessels to point out how the Jetyak Autonomous Surface Vessel (ASV) came to be and why it and ASVs such as the Wave Glider are unique platforms and the design lessons we can learn from them. Finally, we present a taxonomy of vehicles and applications across multiple, mostly orthogonal axes. This analysis highlights two important issues for the field physical constraints that are hard limiting factors, and areas where future innovations may arise. The axes along which we conduct this exercise include endurance (battery capacity), spatial sampling scales (cm to 100s of kilometers), temporal sampling scales (sub second to hours, days, weeks, and months), depth rating, manipulation capabilities, and docking technologies.
Plenty of calcification: imaging characterization of polymorphous low-grade neuroepithelial tumor of the young

Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a recently described epileptogenic neoplasm. As the name implies, PLNTYs are indolent tumors most often encountered in the pediatric or young adult population. The imaging features of PLNTY are not well characterized in the existing literature. We performed a retrospective review, identifying nine patients with pathologically proven PLNTY and available preoperative imaging in order to identify common features which may facilitate confident imaging diagnosis of this entity. Patients were ages 5 to 34 years (median 16 years), and seven (78%) were female. Most tumors had a highly characteristic appearance, with temporal lobe location (6/9; 67%), calcification (8/9; 89%), cortical/subcortical origin (8/9; 89%), cystic components (8/9; 89%), and relatively infrequent contrast enhancement (3/9; 33%). PLNTYs demonstrate characteristic calcification, subcortical location, and frequent temporal lobe localization, features that may allow radiologists to prospectively suggest the diagnosis in the proper clinical setting.
If only journals could talk: Abiola Irele’s “contemplative vitalism”

This study locates and names as “contemplative vitalism” the nucleus of Abiola Irele's massive analyses of the complex trajectories of Africa-inflected 20th century intellectual history, particular...
HIV-1 Broadly Neutralizing Antibodies Take the Road Less Traveled, and That Makes All the Difference.

Broadly neutralizing antibodies (bnAbs) against HIV-1 provide critical insights into co-evolution between the virus and human B cell responses. In this issue of Cell Host & Microbe, Shen et al. (2020) describe a rare mutation in an antibody lineage targeting the fusion peptide of HIV-1 envelope creating a critical bifurcation, with only one path leading to bnAb development.
Enabling Fine-grained Finger Gesture Recognition on Commodity WiFi Devices

Gesture recognition has become increasingly important in human-computer interaction and can support different applications such as smart home, VR, and gaming. Traditional approaches usually rely on dedicated sensors that are worn by the user or cameras that require line of sight. In this paper, we present fine-grained finger gesture recognition by using commodity WiFi without requiring user to wear any sensors. Our system takes advantages of the fine-grained Channel State Information available from commodity WiFi devices and the prevalence of WiFi network infrastructures. It senses and identifies subtle movements of finger gestures by examining the unique patterns exhibited in the detailed CSI. We devise environmental noise removal mechanism to mitigate the effect of signal dynamic due to the environment changes. Moreover, we propose to capture the intrinsic gesture behavior to deal with individual diversity and gesture inconsistency. Lastly, we utilize multiple WiFi links and larger bandwidth at 5GHz to achieve finger gesture recognition under multi-user scenario. Our experimental evaluation in different environments demonstrates that our system can achieve over 90% recognition accuracy and is robust to both environment changes and individual diversity. Results also show that our system can provide accurate gesture recognition under different scenarios.
ITINERARIOS DEL CUERPO, ECONOMÍA Y ERÓTICA DEL VIAJE EN EL ENTRESIGLO LATINOAMERICANO

Este articulo propone discutir el viaje y la extranjeria como experiencias corporales que interrumpen la idea de progreso y productividad de la modernidad y la modernizacion. Aborda los itinerarios...
Incidence of EEG seizures in patients with intraparenchymal hemorrhage re-veals a significant role for subcortical hemorrhages in epileptogenicity. (P5.286)

Objective: To look for the incidence of seizures and abnormal EEG in patients with IPH, particularly those patients with deep IPH. Background: NA Design/Methods: A retrotrospective chart review of 121 patients who had undergone CT or MRI brain and continuous EEG (cEEG) monitoring from January 2013 to December 2014 was conducted. Eleven patients with isolated cerebellar or brainstem hemorrhages were excluded. Abnormal EEG was defined as the presence of periodic lateralized epileptiform discharges (PLEDS) and seizures. Deep IPH was defined as subcortical white matter, thalamic or basal ganglia IPH. Results: Twenty five (22.73%) of the 110 patients had an abnormal EEG. Of the 110 patients, 40 (36.36%) had subcortical white matter or thalamic or basal ganglia IPH +/− IVH. A total of 18 (16.36% of the 110) patients had EEG seizures. Of these 18 patients, 5 (27.78%) patients had deep IPH +/− IVH. Eleven (61.11%) of the 18 had cortical hemorrhage +/− IVH[OR=0.71, CI=0.23 to 2.23, p=0.56]. Two (10.5 %) additional patients had both cortical and deep IPH. Additionally, of the 25 patients with abnormal EEG, 7(28%) patients had deep IPH +/− IVH. Fifteen(60%) of the 25 patients had cortical hemorrhage +/− IVH. Three additional patients with both cortical and deep IPH were eliminated. Thus 17.5% of patients with deep IPH and 22.7% of patients with cortical IPH had abnormal cEEG.[OR=0.55, CI=0.20 to 1.48, p=0.23]. Conclusions: Subcortical IPH is a common etiology of IPH and often overlooked in terms of seizure risk. A significant portion of the patients with IPH and seizures on cEEG monitoring had subcortical hemorrhages accounting for 28% of cases with seizures and abnormal EEG as well as for 13% of all the patients with subcortical ICHs. Thus patients with supratentorial IPH, specifically subcortical IPH should be evaluated for subclinical seizures. Disclosure: Dr. Parikh has nothing to disclose. Dr. Punia has nothing to disclose. Dr. George has nothing to disclose. Dr. Hantus has nothing to disclose.
An Accident Waiting to Happen: Copyright Material IEEE Paper No. ESW2028-28

Homemade equipment - to save money Non-performing craft - because management doesn't want to have the hard discussion Unqualified personnel - because we need the bodies on the job A lack of formal procedures - because they take a lot of time and effort to write A deviation from lockout/tagout protocol - because it was quicker Any one of these can be the prelude to a serious electrical incident. Mix them all together and you have a recipe for a catastrophic failure which resulted in a near fatality and a cost to the company of millions of dollars.