cssi/SciSciGPT-SciSciNet huggingface dataset:
O último conto policial de Borges e o que havia no labirinto

This essay makes two different, though related claims. On the one hand, it suggests that Borges' detective story"Ibn Hakkan Al-Bokhari, Dead in his Labyrinth" was written in such a way that the role of the detective has to be played by the reader. This is a model Borges himself had proposed in"Examination of the Works of Herbert Quain." I claim that the solution at the end of the story is only provisional, and I propose a possible alternative solution. On the other hand, I place this story within the broader frame of Borges' narrative poetics and conception of the reader. I advance the idea that this poetics should be seen as the invention of a new reader, one that arises from the combination of two strong, and in many ways opposed, reading models: those provided by the sacred text and by detective fiction. I claim that this unprecedented combination is one of Borges' main contributions to the renewal of the short story as a literary genre, and that its virtuosic execution in this story leads us to reconsider it as a major piece in the body of Borges' narrative.
Basic Properties of Continuous Parameter Supermartingales

The continuity properties of continuous parameter supermartingales derived in this section are of course also valid for continuous parameter sub-martingales and martingales. Recall that a process is said to be [almost surely] [right continuous if [almost] every sample function is right continuous and the process is said to be [almost surely] right continuous with left limits if [almost] every sample function is right continuous and has a left limit at every point.
What is love? An empirically-based essentialist account

This two-part study investigates new possibilities in our understanding of the nature of love. Evidence collected lends preliminary support to the following contentions: First, Persons’ concepts of human love of various kinds may not be, as widely maintained, Roschian prototypical ones, but may instead be definable, essentialist ones. Second, Foremost among love’s essential characteristics in terms of transcending four different kinds of love (romantic, parental, companionate, and altruistic) may be “Investment in the well-being of the other for his or her own sake.” Third, Persons’ models or prototypes of romantic, parental, companionate, and altruistic relationships may be different from and broader than their essentialist concepts of love itself of each of these kinds.
G Protein–Coupled Receptors

This Teaching Resource provides lecture notes and slides for a class covering G protein–coupled receptors (GPCRs) and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with a discussion of the major classes of GPCRs and then proceeds to describe the mechanisms of receptor diversity, ligand interaction, desensitization, coupling, and mutations associated with human diseases.
Being‐in‐Christ and Putting Death in Its Place: An Anthropologist's Account of Christian Performance in Spanish America and the American South

Being-in-Christ and Putting Death in Its Place: An Anthropologist's Account of Christian Performance in Spanish America and the American South. Miles Richardson. Baton Rouge: Louisiana State University Press, 2003. 414 pp.
Approximation of Generator Coherency Based on Synchronization Coefficients

Dynamically coupled or coherent groups of generators are likely to occur between strongly connected generators connected to the system through weak or strained transmission lines. Establishing which machines in a system are dynamically coupled has shown to be helpful in identifying coherent areas for aggregation, providing insights into system stability, and for showing potential stability limits. Synchronizing coefficients between machines is a well established measure for the level of influence that machines have on each other. The synchronizing coefficients reflect not only the strength of the connections between machines but also include the effects of system loading. This paper proposes a method to approximate dynamic coupling or coherency based on direct evaluation of the synchronizing coefficient magnitudes. It is shown that estimation of the dynamic coupling in this manner has the benefit of being computationally simple without requiring any additional information beyond the load flow data.
Normalization of transposon-mutant library sequencing datasets to improve identification of conditionally essential genes

Sequencing of transposon-mutant libraries using next-generation sequencing (TnSeq) has become a popular method for determining which genes and non-coding regions are essential for growth under various conditions in bacteria. For methods that rely on quantitative comparison of counts of reads at transposon insertion sites, proper normalization of TnSeq datasets is vitally important. Real TnSeq datasets are often noisy and exhibit a significant skew that can be dominated by high counts at a small number of sites (often for non-biological reasons). If two datasets that are not appropriately normalized are compared, it might cause the artifactual appearance of Differentially Essential (DE) genes in a statistical test, constituting type I errors (false positives). In this paper, we propose a novel method for normalization of TnSeq datasets that corrects for the skew of read-count distributions by fitting them to a Beta-Geometric distribution. We show that this read-count correction procedure reduces the number of false positives when comparing replicate datasets grown under the same conditions (for which no genuine differences in essentiality are expected). We compare these results to results obtained with other normalization procedures, and show that it results in greater reduction in the number of false positives. In addition we investigate the effects of normalization on the detection of DE genes.
Perceptions about the relative importance of patient care-related topics: a single institutional survey of its anesthesiologists, nurse anesthetists, and surgeons

Persistently variable success has been experienced in locally translating even well-grounded national clinical practice guidelines, including in the perioperative setting. We have sought greater applicability and acceptance of clinical practice guidelines and protocols with our novel Perioperative Risk Optimization and Management Planning Tool (PROMPT™). This study was undertaken to survey our institutional perioperative clinicians regarding (a) their qualitative recommendations for (b) their quantitative perceptions of the relative importance of a series of clinical issues and patient medical conditions as potential topics for creating a PROMPT™. We applied a mixed methods research design that involved collecting, analyzing, and “mixing” both qualitative and quantitative methods and data in a single study to answer a research question. Survey One was qualitative in nature and asked the study participants to list as free text up to 12 patient medical conditions or clinical issues that they perceived to be high priority topics for development of a PROMPT™. Survey Two was quantitative in nature and asked the study participants to rate each of these 57 specific, pre-selected clinical issues and patient medical conditions on an 11-point Likert scale of perceived importance as a potential topic for a PROMPT™. The two electronic, online surveys were completed by participants who were recruited from the faculty in our Department of Anesthesiology and Perioperative Medicine and Department of Surgery, and the cohort of hospital-employed certified registered nurse anesthetists. A total of 57 possible topics for a PROMPT™ was created and prioritized by our stakeholders. A strong correlation (r = 0.82, 95 % CI: 0.71, 0.89, P < 0.001) was observed between the quantitative clinician survey rating scores reported by the anesthesiologists/certified registered nurse anesthetists versus the surgeons. The quantitative survey displayed strong inter-rater reliability (ICC = 0.92, P < 0.001). Our qualitative clinician stakeholder survey generated a comprehensive roster of clinical issues and patient medical conditions. Our subsequent quantitative clinician stakeholder survey indicated that there is generally strong agreement among anesthesiologists/certified registered nurse anesthetists and surgeons about the relative importance of these clinical issues and patient medical conditions as potential topics for perioperative optimization and risk management.
Translation — 9/11: Terrorism, Immigration, Language Politics

As my book The Translation Zone: a New Comparative Literature (2006) neared completion, I noticed that the topic of translation was increasingly coming out from behind the shadows of academic discussion and into the light of the cultural mainstream. Films such as Sophia Coppola’s Lost in Translation (2003), in which the Japanese language is associated with a high-rise Tokyo hotel, walling the American traveller into psychic anomie; Sydney Pollack’s The Interpreter (2005), featuring a translator at the United Nations entangled in a plot to assassinate an African leader; or Alejandro Gonzalez Inarritu’s Babel (2006), a ‘global’ version of the multi-ethnic metropolis movie Crash (2005) drawing English, Arabic, Spanish and Japanese into suspense-ful relationality, have all highlighted the mystery of untranslatability and the paranoia-inducing closure of foreign language worlds. Books like Gregory Rabassa’s 2005 memoir If This Be Treason: Translation and its Discontents, Hector Tobar’s Translation Nation (2005), a look at the bilingual culture of Los Angeles, and Temple Grandin and Catherine Johnson’s Animals in Translation: Using the Mysteries of Autism to Decode Animal Behavior (2005) also capitalized on the premise that translation carries you over to some other place, a different site of consciousness, cultural space, national or even species affiliation.
Gliomatosis peritonei:a clinicopathological observation

Objective To study the pathogenesis,clinicopathological features and prognosis of gliomatosis peritonei(GP).Methods A case of GP was analyzed by light microscopy and immunohistochemistry and related literatures were reviewed.Results A 10-year-old girl presented with abdominal distension.CT showed a huge cystic and solid mass in the abdominal cavity.Macroscopically,the tumor measured 21?cm× 18?cm× 7?cm with intact capsule and local adhesion of omentum.Neumerous,grey-white nodules,0.1?cm to 0.5?cm in diameter,were noted on the surface of the tumor and omentum.Microscopically,the ovary tumor was composed of mature epidermal,mesodermal and endodermal elements with large amount of glial tissue.Numerous omental nodules were composed of mature glial tissue.Immunohistochemically,glial fibrillary acid protein(GFAP),S-100 protein,vimentin were positive in the mature glial tissue.Cytokeratin was positive in the mesothelial cells covering the nodules.Conclusion GP is an extremely rare condition which has no adverse effect on the prognosis,but needs a long-term follow-up because of its potential of malignant transformation.
Muscle Fatigue: The Cellular Aspects:

High-intensity contractile activity causes a rapid fall in peak tension or force, a reduced shortening velocity, decline in power, prolonged twitch duration, a sarcolemma action potential with a prolonged duration, reduced amplitude, and a conduction velocity that may result in conduction block. The calcium transient is characterized by a reduced amplitude and prolonged duration. What is the role of hydrogen in high-intensity exercise? It may affect E-C coupling but we do not think so. It definitely inhibits the rate of force development and calcium binding to TN-C. It also definitely inhibits the cross-bridge transition from the low to high force state. It inhibits velocity or the cross-bridge cycle rate and, therefore, decreases power and, importantly, prolongs the rate of calcium reuptake by inhibiting the sarcoplasmic reticulum calcium ATPase pump. Phosphate inhibits tension by reversing the cross-bridge transition from the low to the high force state, but it does not affect cycle rate; therefore, it does not have an effect on velocity. It may be involved in decreasing the free energy of ATP hydrolysis, which would provide less energy and, most importantly, play a role in inhibiting the sarcoplasmic reticulum calcium reuptake. Finally, what does all this mean to the athlete and how can fatigue be prevented? Basically, we do not have answers to these questions, but it is clear that the athlete is going to have to have a varied training program. If an athlete trains with one particular type of exercise, fatigue will result from other factors. Thus, a heterogeneous training program is essential. Diet is very important, and warm-up and fluid replacement are all factors that are going to be important in triggering peak performance.
CD10/neutral endopeptidase 24.11 is phosphorylated by casein kinase II and coassociates with other phosphoproteins including the lyn Src-related kinase

CD10/neutral endopeptidase 24.11 (NEP) regulates peptidemediated proliferation of lymphoid progenitors and certain epithelial cells and is itself regulated by cellular proliferation. To further characterize mechanisms by which cell-surface signaling might regulate CD10/NEP expression, we determined whether CD10/NEP was phosphorylated and whether the enzyme co-associated with additional cellular phosphoproteins. The CD10/NEP cytoplasmic tall contains two consensus recognition sequences for casein kinase II (CKII), a serine and threonine kinase that increases in activity following peptide signaling. In standard in vitro kinase assays, CKII phosphorylated full-length recombinant CD10/NEP but did not phosphorylate a truncated CD10/NEP protein that lacked the transmembrane region and cytoplasmic tail. To determine whether CD10/NEP might interact with additional cellular phosphoproteins, in vitro kinase assays were performed on CD10/NEP immune complexes from Nalm-6 cells. Three additional tyrosine phosphoproteins of approximately 40 kD, approximately 58 kD, and approximately 75 kD were identified in the CD10/NEP immunoprecipitates. The approximately 56-kD CD10/NEP-associated phosphoprotein was immunoprecipitated with an anti-lyn antibody confirming its identity as the lyn src-related kinase. Taken together, these data indicate that CD10/NEP is itself phosphorylated by CKII and that CD10/NEP co- associates with additional tyrosine phosphoproteins including lyn.
Carbamylation of the chains of hemoglobin S by cyanate in vitro and in vivo.

Carbamylation of the NH2-terminal valine residues of hemoglobin by cyanate in vitro is about 2½ times as extensive in partially deoxygenated whole blood (40 to 50% oxygen saturation) as in fully oxygenated whole blood. When the carbamylated α and β chains of deoxyhemoglobin are separated, analyses show that the ratio of carbamylation is about 1.7:1 in favor of the α chain, whereas in fully oxygenated hemoglobin the ration is 1:1. The distribution of carbamyl groups on the hemoglobin chains prepared from the blood of patients on oral cyanate therapy suggests that carbamylation in vivo takes place predominantly with the deoxygenated protein.
An unusual case of disseminated adenovirus infection in a cystic fibrosis, liver transplant patient.

• HAdV infection should be considered as a source of disease in the pediatric solid organ transplant population, causing severe disseminated disease or having an atypical presentation including hepatic focal lesions with absence of liver necrosis.
Heavy Ground: William Mulholland and the St. Francis Dam Disaster. By Norris Hundley Jr. and Donald C. Jackson

Heavy Ground: William Mulholland and the St. Francis Dam Disaster. Western Histories Series. By Norris Hundley Jr. and Donald C. Jackson. (Oakland: University of California Press, 2015. viii + 440 pp. Illustrations, maps, appendices, notes, index. $55.00, £37.95). On March 12, 1928, the St. Francis Dam in the Santa Clara River Valley north of Los Angeles collapsed with 12 billion gallons of water creating a tsunami of death and destruction on its way to the Pacific Ocean. The flood killed an estimated 400-450 people and devastated the landscape. Except for the pioneering work of Charles Outland, few historians have conducted in-depth research into the causes and consequences of this tragedy. In recent years it has at last attracted scholarly attention, with studies by J. David Rogers and Jon … hoffmanaz{at}gmail.com
Stress management, leukocyte transcriptional changes and breast cancer recurrence in a randomized trial: An exploratory analysis.

Purpose Cognitive behavioral stress management (CBSM) is an empirically-validated group-based psychosocial intervention. CBSM is related to decreased self-reported indicators of psychological adversity during breast cancer treatment and greater disease-free survival (DFS) vs. a control condition. This study examined relationships between CBSM, DFS, and a potential biobehavioral pathway linking these variables in breast cancer patients through a gene expression composite representing the leukocyte conserved transcriptional response to adversity (CTRA).
Imaging the motility and chemotaxis machineries in Helicobacter pylori by cryo-electron tomography.

Helicobacter pylori is a bacterial pathogen that can cause many gastrointestinal diseases, including ulcers and gastric cancer. A unique chemotaxis-mediated motility is critical for H. pylori to colonize in the human stomach and to establish chronic infection, but the underlying molecular mechanisms are not well understood. Here, we employ cryo-electron tomography (cryo-ET) to reveal detailed structures of the H. pylori cell envelope, including the sheathed flagella and chemotaxis arrays. Notably, H. pylori possesses a distinctive periplasmic cage-like structure with 18-fold symmetry. We propose that this structure forms a robust platform for recruiting 18 torque generators, which likely provide the higher torque needed for swimming in high-viscosity environments. We also reveal a series of key flagellar assembly intermediates, providing structural evidence that flagellar assembly is tightly coupled with the biogenesis of the membrane sheath. Finally, we determine the structure of putative chemotaxis arrays at the flagellar pole, which have implications for how the direction of flagellar rotation is regulated. Together, our pilot cryo-ET studies provide novel structural insights into the unipolar flagella of H. pylori and lay a foundation for a better understanding of the unique motility of this organism. IMPORTANCE Helicobacter pylori is a highly motile bacterial pathogen that colonizes approximately 50% of the world's population. H. pylori can move readily within the viscous mucosal layer of the stomach. It has become increasingly clear that its unique flagella-driven motility is essential for successful gastric colonization and pathogenesis. Here, we use advanced imaging techniques to visualize novel in situ structures with unprecedented detail in intact H. pylori cells. Remarkably, H. pylori possesses multiple unipolar flagella, which are driven by one of the largest flagellar motors found in bacteria. These large motors presumably provide the higher torque needed by the bacterial pathogens to navigate in the viscous environment of the human stomach.
Dried Plums, Prunes and Bone Health: A Comprehensive Review

The 2015–2020 Dietary Guidelines for Americans advocate for increasing fruit intake and replacing energy-dense foods with those that are nutrient-dense. Nutrition across the lifespan is pivotal for the healthy development and maintenance of bone. The National Osteoporosis Foundation estimates that over half of Americans age 50+ have either osteoporosis or low bone mass. Dried plums, also commonly referred to as prunes, have a unique nutrient and dietary bioactive profile and are suggested to exert beneficial effects on bone. To further elucidate and summarize the potential mechanisms and effects of dried plums on bone health, a comprehensive review of the scientific literature was conducted. The PubMed database was searched through 24 January 2017 for all cell, animal, population and clinical studies that examined the effects of dried plums and/or extracts of the former on markers of bone health. Twenty-four studies were included in the review and summarized in table form. The beneficial effects of dried plums on bone health may be in part due to the variety of phenolics present in the fruit. Animal and cell studies suggest that dried plums and/or their extracts enhance bone formation and inhibit bone resorption through their actions on cell signaling pathways that influence osteoblast and osteoclast differentiation. These studies are consistent with clinical studies that show that dried plums may exert beneficial effects on bone mineral density (BMD). Long-term prospective cohort studies using fractures and BMD as primary endpoints are needed to confirm the effects of smaller clinical, animal and mechanistic studies. Clinical and prospective cohort studies in men are also needed, since they represent roughly 29% of fractures, and likewise, diverse race and ethnic groups. No adverse effects were noted among any of the studies included in this comprehensive review. While the data are not completely consistent, this review suggests that postmenopausal women may safely consume dried plums as part of their fruit intake recommendations given their potential to have protective effects on bone loss.
Modeling, Analysis and Design of Bio-hybrid Micro-robotic Swarms for Medical Applications

In this chapter, we present a cyber-physical approach towards the design of bio-hybrid micro-robotic swarms that can achieve various complex tasks at micro-level in a minimal invasive manner, such as abnormal tissue detection and drug delivery in hardly accessible regions of the human body. To this end, we cease to view micro-robots as passive point-like particles, but rather as interactive Turing machines performing complex biochemical processing, as well as physical interactions in a realistic 3D environment. Our theoretical framework is based on a non-equilibrium statistical physics approach capable of accounting for attraction and repulsion interactions among micro-robots, as well as the volume exclusion effects. To account for biological sensing, interacting, actuation dynamics, and the 3D complex tumor microenvironment, we also use an open-source 3D multiscale simulator specifically developed for this research. Taken together, the theoretical framework and computational platform we develop can enable various design trade-offs of interacting bio-hybrid micro-robotic swarms for future medical applications.
Quality Attributes of Sweet Sorghum for the Large-Scale Production of Bioproducts: A 1-Year Comparison of Commercial Hybrids and a Cultivar

Quality attributes of sweet sorghum affect the industrial processing of this biomass into biofuels and bioproducts. In a 1-year study, two commercial sweet sorghum hybrids 105 and 106, late and early maturing, respectively, were compared to inbred, later-maturing Top 76-6 cultivar, for quality attributes at the soft dough (SD) and hard dough (HD) maturity stages. Crops were grown in South Louisiana, and juice was extracted from topped whole stalks by roller milling. Crop biomass yields varied (P Top 76-6 > 106, with hybrid 106 containing markedly more auxiliary seed head/stalk (side-branch tillers) compared to none in hybrid 105 and only 0.5% in Top 76-6 at HD. For the three genotypes, the stalk contributed between 63.8 and 86.5% of the fresh weight biomass which decreased from SD to HD. The growth parameters of crop yield, and stalk biomass, height, wet weight, first internode diameter, and to a lesser degree hardness of the last internode were strongly, negatively correlated with both soluble and insoluble starch in the raw juice. This suggested that increased growth/maturity of the genotypes tended to reduce starch. Overall, except for significantly (P < 0.05) lower mode values in the hybrids compared to Top 76-6, there were little statistical differences in starch granule size parameters. Further studies are now warranted to ascertain environmental effects on quality.
Metallic surface states in elemental electrides

Recent high-pressure studies have uncovered an alternative class of materials, insulating electride phases created by compression of simple metals. These exotic insulating phases develop an unusual electronic structure: the valence electrons move away from the nuclei and condense at interstitial sites, thereby acquiring the role of atomic anions or even molecules. We show that they are also topological phases as they exhibit a wide diversity of metallic surface states (SSs) that are controlled by the bulk electronic structure. The electronic reconstruction occurs that involves charge transfer between the surfaces of opposite polarity making both of them metallic, resembling the appearance of the two-dimensional gas at the renowned $\mathrm{SrTi}{\mathrm{O}}_{3}/\mathrm{LaAl}{\mathrm{O}}_{3}$ interface. Remarkably, these materials thus embody seemingly disparate physical concepts---chemical electron localization, topological control of bulk-surface conductivity, and the two-dimensional electron gas. Such metallic SSs could be probed by direct electrical resistance or by standard photoemission measurements on recovery to ambient conditions.
Less Hope, More Paint: On the Political War Being Waged in Urban Contexts

In this response to the call for transformative models of teaching students in urban contexts, the author presents his own experiences in becoming a critical pedagogue, the path that led him there,...
Imaging Following Treatment of Lung Cancer

Patients who receive curative intent therapy need adequate follow-up imaging. The purpose of imaging in these patients is to identify and manage complications related to the curative intent therapy itself, including managing postoperative complications of surgery, chemotherapy, and radiation therapy, and to measure the tumor to document response and to detect recurrences of the primary lung cancer and/or development of a new primary lung cancer early enough to allow potentially curative retreatment.
Sleep in Amyotrophic Lateral Sclerosis

This review was conducted in order to identify sleep disorders in amyotrophic lateral sclerosis, as insomnia and fatigue are common complaints. Sleep quality is impaired in amyotrophic lateral sclerosis due to sleep-disordered breathing, loss of REM atonia, movement disorders, nocturnal cramps, and fasciculations. Sleep-disordered breathing consists predominantly of pseudo-central events related to diaphragm weakness with additional impairment in the central control of breathing. From a pathophysiologic perspective, diaphragmatic weakness, bulbar dysfunction, central neurodegeneration, neuronal hyperexcitability, and denervation all play a role. Noninvasive ventilation to address sleep-disordered breathing improves long-term sleep quality. Pharmacologic interventions may be needed for cramps, REM behavior disorder, insomnia, and movement disorders. However, not all disorders require treatment. For instance, loss of REM atonia may protect against sleep-disordered breathing, and the impact of the restless legs syndrome on morbidity is unclear. Future research can address the role of nocturnal polysomnography in guiding noninvasive ventilation settings.
Molecular Dynamics Simulations of Tribology

Publisher Summary This chapter provides an overview of the molecular dynamics (MD) technique and reactive potentials with special regard to their use in investigating atomic-scale friction. In MD simulations, atoms are treated as discrete particles whose trajectories are followed by numerically integrating the classical equations of motion. After the geometry and boundary conditions of the system are specified and the initial position and velocity of each atom are given, a numerical integration is carried out. Typical timesteps range between 0.1 and about 15 femtoseconds, depending on the largest vibrational frequency of the model system. Instantaneous values of quantities such as energy, force, velocity, strain, and stress can be calculated at regular intervals and saved for postsimulation analysis. Atomistic simulation of a large number of atoms using molecular dynamics is a powerful tool for understanding the fundamental mechanisms of friction and tribology. The underpinning of such calculations is the assumed atomic interaction potential. The most desirable circumstance would be to take the atomic interactions directly from first-principle calculations; however, such calculations are orders of magnitude too slow for the sheer number of energy evaluations required to study a system of reasonable size and practical interest.
Leptomeningeal metastases in non-small-cell lung cancer.

Summary Leptomeningeal metastasis is a complication of advanced non-small-cell lung cancer (NSCLC). Diagnosis and monitoring of leptomeningeal metastasis are challenging, and are based on neurological, radiographic, and cerebrospinal fluid findings. Substantial progress has been made in several key aspects of management of leptomeningeal metastasis, including improved characterisation of the genetic profiles, generation of clinically relevant animal models, advances in cerebrospinal fluid liquid biopsy with improved cytology and genotyping analysis, and the development of therapeutic agents with greater CNS penetration. This Review discusses cumulative data on multiple treatment modalities with a particular focus on recent advances in molecularly targeted therapies in subtypes of patients with leptomeningeal metastasis from NSCLC. Future research is needed to further understand the biology of leptomeningeal metastasis and the mechanisms of resistance to treatment.
Reduction of vascular complication rates from femoral artery access in contemporary women undergoing cardiac catheterization.

Abstract Background Femoral arterial access (FAA) during diagnostic coronary angiography (CAG) and percutaneous coronary interventions (PCI) are associated with several vascular complications (VC). VC rate in our experience a decade ago was 3.02% and higher in women (4.7% in women, and 1.67% in men, p Methods Patients who underwent CAG and PCI utilizing FAA (n = 2617) were separated into Period 1 (2005 to 2008; 1970 patients; Male 1045; Female 925) and Period 2 (2016–2017; 647 patients; Male 357; Female 290). FA access was preceded by anatomic FA localization during Period 1 vs. additional fluoroscopic marking of femoral head during Period 2. Ultrasound guidance was not utilized during either period. VCs were defined as hematoma>3 cm, major bleeding requiring blood transfusion or hemoglobin drop >2 g, retroperitoneal bleed, pseudoaneurysm, AV fistula, arterial thrombosis, distal embolism, dissection, and transient limb ischemia. Results Rate of VCs did not differ from Periods 1 to 2 (2.44% vs. 2.32%, p = 1.0). An elevated rate of VCs experienced by women in Period 1 (Female 3.68% vs. Male 1.34%, p Conclusions The use of fluoroscopic marking of femoral head prior to access, smaller sheath size, and being a high femoral volume center may have contributed to the reduced incidence of VCs in women. VCD utilization is continuing to reduce VC rates in both men and women.
Masks and the Space of Play

Masks are devices and symbols. In the first instance, they are artifacts that allow opposite poles to take each other’s place. They split the world into appearance and reality, manifest and repressed, sacred and profane. In this sense, they are dualistic. But by so doing they invert these terms. In this sense, they are dialectical. In the second instance, they exemplify doubt about people’s identities and the veracity of their words; they denote duplicity, inauthenticity, and hypocrisy. The conjunction of these two senses resides in the fact that masks are at the threshold between reality and fiction. Such a threshold makes possible the emergence of a space of play which asserts that the world does not express a determinate and final order but is infinitely open to the emergence of new, yet transient, forms of self-organization and open new spatiotemporal worlds.
Behind the Legend

In 2017 a new biography, Behind the Legend - The Many Worlds of Charles Todd, by Denis Cryle, was published. The biography seeks to provide a more complete understanding of Charles Todd beyond the single achievement for which he became most famous the building of the Overland Telegraph Line linking Darwin and Adelaide in 1872. The biography lives up to its promise and sets out in considerable detail the contribution that Todd made in many fields during his long lifetime and period of public service. Those fields include astronomy, meteorology, telegraphy, telecommunications more generally, public administration, and contribution to the processes of federal coordination and cooperation. Todds fame and legacy have been heavily bound up with the construction of the Overland Telegraph Line. As Cryle notes, he was dubbed Telegraph Todd by the media of the day. It is the stated purpose of Cryles biography to do justice to Todd across the full range of his achievements. I think that Cryle succeeds admirably. He has written an engaging book that is thoroughly researched and referenced. It will appeal both to historians and to the general reader without expertise in any of the scientific or technical fields inhabited by Todd.
Global challenges and adaptations in management practices to preserve soil carbon pool with changing climate

Increasing CO2 levels and its consequent effects have been prominent with climate change. Three out of ten transgressed planetary boundaries reflect our planet’s status at tipping point. Soil Organic Carbon (SOC) which helps soil supply water and nutrients to plants through roots is inherently related to various ecological systems and needs urgent attention. Although the total SOC globally is more than the total carbon in biosphere and atmosphere, the vulnerability of SOC due to anthropogenic activities is unavoidable. The environmental factors affecting sequestration of SOC, soil fertility, crop production, accelerated SOC removal with rising temperatures, green-house gases emissions and climate change are interrelated. Thus, it is impossible to understand and estimate the various scenarios of impacts on SOC pool with ever-changing ecosystems and related processes in soil environment completely. Based on currently predicted climate change scenarios, if deforestation is controlled and reestablishment is achieved, tropical forests can trap atmospheric CO2 in the cheapest way and function as the largest sink on earth. The agricultural management practices (AMPs), which have been practiced in the last two decades and found helpful are suitable. However, some innovative adaptations such as crop modelling, selecting types of residue to change microbial communities, practices of grassland-grazing and low-C-emission AMPs are also necessary. To achieve the millennium development goals, we must accomplish food security, which relates all 17 sustainable development goals (SDGs) also relays agricultural systems, soil systems, ecosystem services, soil fertility and how best we nurture SOC pool with supportive AMPs.
Pulmonary Embolism and Deep Venous Thrombosis Following Extracorporeal Shock Wave Lithotripsy

Among 500 patients undergoing extracorporeal shock wave lithotripsy (ESWL) with the Dornier HM3 lithotripter at the Midwest Stone Institute, a postoperative pulmonary embolus (PE) occurred in three. Serial impedance plethysmography and Doppler flow studies were performed in 16 patients at high risk for thromhosis to determine whether the position of the patient in the gantry might cause deep venous thrombosis (DVT) and subsequent PE. None of these patients developed any evidence of DVT following ESWL.
Signature Change in Matrix Model Solutions

Various classical solutions to lower dimensional Ishibashi-Kawai-Kitazawa-Tsuchiya--like Lorentzian matrix models are examined in their commutative limit. Poisson manifolds emerge in this limit, and their associated induced and effective metrics are computed. Signature change is found to be a common feature of these manifolds when quadratic and cubic terms are included in the bosonic action. In fact, a single manifold may exhibit multiple signature changes. Regions with a Lorentzian signature may serve as toy models for cosmological spacetimes, complete with cosmological singularities, occurring at the signature change. The singularities are resolved away from the commutative limit. Toy models of open and closed cosmological spacetimes are given in two and four dimensions. The four-dimensional cosmologies are constructed from noncommutative complex projective spaces, and they are found to display a rapid expansion near the initial singularity.
Toward Cyber Workforce Development: An Exploratory Survey of Information Security Professionals

High-profile cases of network intrusions in private organizations are becoming a regular occurrence, illustrating the vulnerabilities in current information technology. Cybersecurity is an emerging...
School Readiness Assessments for Class Placements and Academic Sorting in Kindergarten.

Kindergarten readiness assessments are commonly used in schools nationwide. Prior work shows that the use of such assessments for class placement decisions has increased in recent years. This artic...
Three dimensional secondary ion mass spectrometry imaging (3D-SIMS) of Aedes aegypti ovarian follicles

The mobilization of nutrient reserves into the ovaries of Aedes aegypti mosquitoes after sugar-feeding plays a vital role in the female's reproductive maturation. In the present work, three-dimensional secondary ion mass spectrometry imaging (3D-SIMS) was used to generate ultrahigh spatial resolution (~1 μm) chemical maps and study the composition and spatial distribution of lipids at the single ovarian follicle level (~100 μm in size). 3D-Mass Spectrometry Imaging (3D-MSI) allowed the identification of cellular types in the follicle (oocyte, nurse and follicular cells) using endogenous markers, and revealed that most of the triacyglycerides (TGs) were compartmentalized in the oocyte region. By comparing follicles from water-fed and sugar-fed females (n=2), 3D-MSI-Time of Flight-SIMS showed that TGs were more abundant in ovarian follicles of sugar-fed females; despite relative sample reproducibility per feeding condition, more biological replicates will better support the trends observed. While the current 3D-MSI-TOF-SIMS does not permit MS/MS analysis of the lipid species, complementary LC-MS/MS analysis of the ovarian follicles aided tentative lipid assignments of the SIMS data. The combination of these MS approaches is giving us a first glimpse of the distribution of functionally relevant ovarian lipid molecules at the cellular level. These new tools can be used to investigate the roles of different lipids on follicle fitness and overall mosquito reproductive output.
Lattice Monte Carlo simulations as link between ab-initio calculations and macroscopic behavior of dopants and defects in silicon

In this work, we show that lattice Monte Carlo simulations can be used to span the time and distance scales between underlying atomistic processes and macroscopic diffusion behavior. We use ab- initio calculations of binding energies versus configuration to calculate hopping rates of vacancies for use in lattice Monte Carlo (LMC) simulations of diffusion and aggregation in silicon. The LMC simulations consider the biased nature of vacancy hop frequencies in the neighborhood of dopants, with interactions up to sixth-nearest- neighbor distances included. We use these simulations to investigate the expected macroscopic diffusion behavior, as well as the process by which dopant/defect aggregation occurs. Specific phenomena investigated include collective behavior leading to greatly enhanced diffusivity at high doping levels, the time dependence of effective diffusivity due to the formation of dopant/vacancy clusters, and dopant fluxes in the presence of a vacancy gradient.
1259-P: Adherence and Persistence for Dulaglutide (DU) vs. Basal Insulin (BI) in Injection-Naïve Patients with Type 2 Diabetes (T2D): The DISPELTM Study

Adherence and persistence are key considerations in patient-centric treatment selection for T2D management. The objective of this retrospective real-world study was to assess 1-year adherence and persistence using different measures among injection naive patients with T2D initiating DU vs. BI. A U.S. claims database was used to identify patients with T2D initiating DU or BI between Nov’14 - Apr’17 (index date=earliest fill date). Patients ≥18 years, with no claim for any antidiabetic injectable in the 6 months pre-index period (baseline), continuous enrollment and ≥1 HbA1c result at baseline and 1-year post-index were included. Two widely used measures for assessing persistence of injectables in the real-world were implemented. DU users were propensity-matched 1:1 to BI users. Matched cohorts (903 pairs) were balanced in baseline patient characteristics with mean age of 54 years. Key study outcomes are included in the Table. Using the 45-day gap measure, more BI vs. DU patients discontinued their therapy but more BI patients restarted their index therapy. More DU vs. BI patients discontinued based on the 90th percentile measure, and more DU patients restarted their index therapy. In this real-world study, DU demonstrated higher adherence than BI. Given the results, the most appropriate persistence measure may vary for different classes of antidiabetic injectables. Disclosure R. Mody: Employee; Self; Eli Lilly and Company. Q. Huang: None. M. Yu: Employee; Self; Eli Lilly and Company. Employee; Spouse/Partner; Lifelabs. Stock/Shareholder; Self; Eli Lilly and Company. L. Wang: Employee; Self; HealthCore. Employee; Spouse/Partner; Janssen Pharmaceuticals, Inc. X. Zhang: None. M. Grabner: None. H. Patel: Employee; Self; Eli Lilly and Company. Stock/Shareholder; Self; Eli Lilly and Company. Funding Eli Lilly and Company
A Pilot Study on Ranking the Critical Components of a System

Components of complex systems are interdependent in various dimensions including physical, functional, and social dimensions. Identifying and understanding critical components of a system have many implications in terms of system analysis, design, and operation. Systems consist of many components some of which are more significant than the others. A component is deemed significant if it is part of the structural core or architecture of a system, and proper operation of the rest of the system relies on the correct functioning of this component. Identifying such significant components is important since change is inevitable as a normal course of evolution in any system, and critical components of the systems must not only be designed to be reliable but also designed to minimize their impact on change. Testability of these components is also critical for ease of diagnosis and troubleshooting for quality assurance. In addition, complex systems carry socio-technical characteristics where understanding critical elements of an organizational structure is important for successful system design and operation. Several different component ranking strategies exist that rank components using their own unique perspective. As such, these ranking strategies behave differently in their ranking of significant components within a system. In this paper, we propose a discrete-time Markov chain-based algorithm for ranking the components of the system and compare its ranking with three commonly used ranking strategies, namely, closeness, betweenness, and eigenvector centrality. In our pilot study on three different systems, Markov chain outperformed other ranking strategies in highly ranking the significant components of the system.
Everyone can do Differential Equations

Abstract: The original research is to make connection between classroom mathematics and real life issues through dynamic models using Excel. After we completed several sample models such as Prey and Predator model, SIR model, we found we did really solve initial value differential equation problems. We even solve initial values system of linear differential equations numerically and graphically. Therefore we extend our research to solve initial value differential equations using the same approach as we create dynamic models. We tested first order and second order differential equations and all got satisfactory numerical solutions.
BOOK REVIEW: Mohawk Interruptus: Political Life Across the Borders of Settler States

Book review of Audra Simpson's (2014) Mohawk Interruptus: Political Life Across the Borders of Settler States
Value Relevance of Corporate Governance Disclosure in Annual Reports: Evidence from Listed Banks in Kenya

This study investigates the value-relevance corporate governance disclosures published in the narrative part of annual reports of ten banks listed at the Nairobi Securities Exchange (NSE) over the entire period from year 2010 to year 2015. This work extends the line of research on value relevance by quantifying narrative accounting, in this case corporate governance disclosures using content analysis. In addition, in line with prior studies, this study employs the Ohlson´s (1995) value-relevance model and finds that corporate governance disclosure is significantly positively related to market value, measured by the average market price per share. The findings reveal that corporate governance disclosures influence investors’ perceptions and are therefore, vital to be included in annual reports, which are a major communication tool.
Incorporating Research Design in Public Diplomacy: The Role of Listening to Foreign Publics

Research design involves a set of decisions regarding what or who will be studied and the procedures in acquiring and analyzing information. In this article, we apply lessons from research design to public diplomacy, a field focused on engaging with foreign publics. Much prior scholarship sheds light on what PD is and its programs, but less attention has been given to the role of listening to understand what foreign publics think and believe. We propose three interrelated recommendations to improve the quality of implementing PD programs. First, before any program is implemented, we need to correctly identify a perceived issue that requires a program. Once we confirm if the issue exists, we also need to understand why it exists. Second, designing PD programs with clear goals increases the effectiveness of the program and the ability to confirm its success. This requires designing programs unique to each case. Third, public opinion data should be collected at several points—taking advantage of time—to confirm the effectiveness of programs. Our recommendations are particularly valuable for policy makers.
Analysis of Lung Gene Expression Reveals a Role for Cl - Channels in Diisocyanate-induced Airway Eosinophilia in a Mouse Model of Asthma Pathology.

Diisocyanates are well-recognized causes of asthma. However, sensitized workers frequently lack diisocyanate-specific IgE, which complicates diagnosis and suggests the disease involves IgE-independ...