cssi/SciSciGPT-SciSciNet huggingface dataset:
Ethnic reorganization: American Indian social, economic, political, and cultural strategies for survival

Abstract In this article, we argue that there is an important, but as yet unidentified, process involved in the maintenance and reconstruction of ethnic identity. We call this process ‘ethnic reorganization’. We argue that this process is useful for understanding the ethnic survival of indigenous peoples in colonized societies, as well as for illuminating the processes of ethnic renascence among both indigenous and immigrant groups. We find it especially useful in accounting for both the persistence and the transformation of American Indian ethnicity in the United States. Ethnic reorganization occurs when an ethnic minority undergoes a reorganization of its social structure, redefinition of ethnic group boundaries, or some other change in response to pressures or demands imposed by the dominant culture. From this viewpoint, ethnic reorganization is a mechanism that facilitates ethnic group survival, albeit in a modified form. We specify several types of ethnic reorganization. These include: social reorgan...
A stable analytic foliation with only exceptional minimal sets

February 25, 2015 call #: Level 1 QA3 .L28 no.468 Borrower: RAPlD:GZM &#39;-°°aq°q’q°‘°5‘ q°qdiq9 Strmg: Billing Category: Exempt Journal Title: Lecture notes in mathematics Maxcost: S &#39; - ( prmger Verlag) Delivery Method: Send via Odyssey Volume: 468 |3sue; email: MonthIYear: 1975 EMAq-3 Pages: 9-10 Article Author: M. Hirsch Shipping Address: NEW: Memorial Library Article Title: A stable analytic foliation with only exceptional minimal sets :117121i1 I||||||Illlilllllllllil||||||||||l||||||||||| ILL Number: -8986333 University of Utah Marriott Library ILL lLLiad TN “NOTICE WARNING CONCERNING COPYRIGHT RESTICTIONSq The copyright law of the United States [Title 17, United States Code] governs the making of photocopies or the other reproductions of copyrighted material. Under certain conditions specified in the law, libraries and archives are authorized to furnish a photocopy or other reproduction. One of these specified conditions is that the reproduction is not to be used for any purpose other than private study, scholarship, or research. If a user makes a request for, or later uses, a photocopy or reproduction for purposes in excess of fair use, that use we use may be liable for copyright infringement. This institution reserves the right to refuse to accept a copying order if, in its judgment, fulfillment of the order would involve violation of copyright law. No further reproduction and distribution of this copy is permitted by transmission or any other means.
Automated Algorithmic Software in Echocardiography: Artificial Intelligence?∗

Assessment of left ventricular (LV) volumes and ejection fraction (EF) is critical to decision making in valvular heart disease, heart failure, and post-infarct care with 2-dimensional echocardiography (2DE) usually serving this task. Unfortunately, even in 2015, 2DE quantitation remains quite
Zn in the +III Oxidation State

The possibility that the group 12 elements Zn, Cd, and Hg can exist in an oxidation state of +III or higher has fascinated chemists for decades. It took nearly 20 years before experiments could confirm the theoretical prediction that Hg indeed can exist in the +IV oxidation state. While this unusual property of Hg is attributed to relativistic effects, Zn, which is much less massive than Hg, has not been expected to have an oxidation state higher than +II. Using density functional theory, we have shown that an oxidation state of +III for Zn can be realized by choosing specific ligands with large electron affinities. We demonstrate this by a systematic study of the interaction of Zn with the ligands F, BO(2), and AuF(6), whose electron affinities are progressively higher (3.4, 4.5, and 8.4 eV, respectively). The discovery of higher oxidation states of elements can help in the formulation of new reactions and hence in the development of new chemistry.
Comparison of Kinetics of TiSi 2 Formation on Si(100) and Si(111)

Refractory-metal silicides are currently receiving widespread attention because of their usefulness as interconnects in VLSI devices. Potentially the most important of these silicides is TiSi 2 . TiSi 2 offers a sharp stable interface, a high process-compatible eutectic temperature, and the lowest resistivity of all refractory-metal silicides. Much of the previous work on TiSi 2 [1-8] has been directed towards the understanding of the kinetics of silicide formation in order to optimize these electrical and interfacial properties. One parameter that may affect the silicide formation is substrate orientation [9]. We have compared the kinetics of formation of TiSi 2 for Ti deposited onto p-type 10Ω-cm Si(100) and Si(111). All process parameters except substrate orientation were identical. 2800A of Ti was electron-beam evaporated at a rate of 20A/s and a background pressure of 9×10 −8 torr onto chemically cleaned (HNO 3 , HF, rinse) Si substrates and subsequently annealed at temperatures between 470°C and 700°C in evacuated sealed quartz tubes. A turbopumped vacuum system was used to evacuate the quartz tube before sealing. A Ti getter was independently heated to remove remaining background contaminants prior to annealing.
High Output Power from an Efficient Praseodymium Doped Fluoride Fibre Amplifier1

The emergence of 1.3µm praseodymium doped fluoride fibre amplifiers has over the past year generated immense interest within the field of optical telecommunications[1], as most current optical fibre systems installed worldwide operate at wavelengths around 1.3µm within the second telecommunications window. A practical device operating within this window is therefore likely to have a major impact on future network design and upgrade strategies. Furthermore, a 1.3µm amplifier could find application within broadband analogue distribution systems due to the lower dispersion penalty, and superior source characteristics at this wavelength as compared to 1.5µm.
Endotracheal Tube Introducer (Bougie)

During orotracheal intubation, when only epiglottic visualization or partial glottic view is obtained during laryngoscopy.
Design of a portable altitude measurement system based on BMP085

A kind of pressure measurement altimeter system based on BMP085 is introduced.The altitude and atmospheric pressure,temperature is relevant.Using digital pressure sensor and microcontroller chip C8051F310 to make serial communication(I2C),the pressure,temperature and compensation parameters from the sensor are read out.Compensation of temperature and calculation of altitude are carried out with the software,and on this basis,the value of the pressure noise processing,the current temperature,pressure,altitude and relative altitude are displayed on the OLED.The whole system integrates the micro-controller with micro-sensor,which has many advantages such as high precision,small size,low power consumption,simple operation,etc.
Children’s Voices and Mediation

When family mediation first came on the American scene in the early 1980s, proponents argued the process would benefit all family members, including children. Very little recent research on the law side has explored whether or not mediation is overall a positive development, though it is now required in a number of states in contested custody cases and is an alternative mechanism in the remainder. The research on advantages or disadvantages to children themselves is still scantier — most studies measure indirect effects. Very few studies from the United States (much less procedures) consider children’s perspectives directly. However, the good research (from a social science standpoint) indicates that children’s interests seem to be served in the mediation context in both expected and unexpected ways (though not in the minority of cases where the parents cannot focus on any interests but their own, or those in which there has been partner violence that should preclude mediation itself). Every study of this kind stresses that it cannot be generalized to larger populations, so more work clearly needs to be done, and perhaps the most valuable information comes from an Australian rather than a U.S. sample.
METASTATIC CARCINOMA OF THE SPINE WITH NEUROLOGIC COMPLICATIONS: AN AUTOPSY REVIEW

Metastatic carcinoma involving the vertebral column and causing spinal cord compression is a common and potentially devastating complication. It has been estimated that 5% of patients with systemic cancer who come to autopsy have pathological evidence of a tumor invading the extradural space [1]. However, the incidence of spinal metastases varies with the primary tumor, for example, breast cancer may have an incidence as high as 70% [2].
Evaluation of CYP2B6 Induction and Prediction of Clinical Drug–Drug Interactions: Considerations from the IQ Consortium Induction Working Group—An Industry Perspective

Drug-drug interactions (DDIs) due to CYP2B6 induction have recently gained prominence and clinical induction risk assessment is recommended by regulatory agencies. This work aimed to evaluate the potency of CYP2B6 versus CYP3A4 induction in vitro and from clinical studies and to assess the predictability of efavirenz versus bupropion as clinical probe substrates of CYP2B6 induction. The analysis indicates that the magnitude of CYP3A4 induction was higher than CYP2B6 both in vitro and in vivo. The magnitude of DDIs caused by induction could not be predicted for bupropion with static or dynamic models. On the other hand, the relative induction score, net effect, and physiologically based pharmacokinetics SimCYP models using efavirenz resulted in improved DDI predictions. Although bupropion and efavirenz have been used and are recommended by regulatory agencies as clinical CYP2B6 probe substrates for DDI studies, CYP3A4 contributes to the metabolism of both probes and is induced by all reference CYP2B6 inducers. Therefore, caution must be taken when interpreting clinical induction results because of the lack of selectivity of these probes. Although in vitro-in vivo extrapolation for efavirenz performed better than bupropion, interpretation of the clinical change in exposure is confounded by the coinduction of CYP2B6 and CYP3A4, as well as the increased contribution of CYP3A4 to efavirenz metabolism under induced conditions. Current methods and probe substrates preclude accurate prediction of CYP2B6 induction. Identification of a sensitive and selective clinical substrate for CYP2B6 (fraction metabolized > 0.9) is needed to improve in vitro-in vivo extrapolation for characterizing the potential for CYP2B6-mediated DDIs. Alternative strategies and a framework for evaluating the CYP2B6 induction risk are proposed.
The Necroculture of Capitalism

In the television series The Walking Dead, survivors of an apocalypse take shelter in a prison, while zombies circle the fences looking for a way in. The zombies are shadows cast by a past to which the survivors cannot return but which they cannot escape. The living dead represent the past that, as Karl Marx wrote, “weighs like a nightmare on the brains of the living.” The prison that holds us today is what right-wing philosopher Francis Fukuyama called “the end of history,” a predicament in which “we cannot picture to ourselves a world that is essentially different from the present one, and at the same time better.”
Abstract 388: Pathway-directed high throughput drug screen identifies PI3K inhibitors that synergistically potentiate anti-tumor activity of HDAC inhibitors in mycosis fungoides and Sézary syndrome

Introduction and Purposes: Mycosis fungoides and Sezary syndrome (MF/SS) represent a group of heterogeneous diseases. Recent studies demonstrated dysregulation of several signaling pathways in MF/SS, including PI3K/AKT, JAK/STAT, RAS and NFκB pathways. We performed a high throughput drug screen to determine the potential of novel agents targeting these pathways for the treatment of MF/SS. Experimental Procedures: We compiled a library of 94 compounds targeting pathways known to be relevant in cancer biology. These included kinases involved in growth factor receptor signaling, HDACs, proteasome, DNA repair and regulators of apoptosis. The compounds were screened for anti-proliferative activity against four MF/SS cell lines in high throughput proliferation assays. Selected hits were further studied in xenograft models of MF/SS and in primary T cell lymphomas. Promising candidates from different classes were also tested in combination therapy assays using a matrix block method across dose gradients of each compound designed to detect synergistic activities. Results: From the high throughput screen, we identified 14 compounds with anti-proliferative activity in MF/SS, including multiple inhibitors of the PI3K pathway. PI3K inhibitors emerged as preliminary hits in this screen and secondary validation assays confirmed the class effect of PI3K inhibitors. From this class, the PI3K inhibitor BKM120 was selected for in vivo studies. In a xenograft model of MF, BKM120 exhibited striking anti-tumor activity measured by a marked suppression of tumor growth and prolonged survival of tumor-bearing mice compared with vehicle control. In a search for even more effective combination therapies, we identified that BKM120 and the HDAC inhibitor class of compounds exhibit synergistic anti-proliferative effects in MF/SS tumor cells. Each of three HDAC inhibitors including LBH, Romidepsin and Vorinostat showed synergistic activity with BKM120, most evident at the GI50 concentrations of each drug, and apparent in both growth inhibition and apoptotic assays. Conclusion: BKM120 is highly active in preclinical models of MF/SS. Furthermore, it synergistically potentiates the effect of HDAC inhibitors against MF/SS tumor cells. These are highly promising approaches for the treatment of MF/SS and warrant clinical investigation. Citation Format: Chen-Yen Yang, Razan Faraj, Taha Rakhshandaroo, Shervin Afghani, Laura Pincus, Sourav Bandyopadhyay, Frank McCormick, Weiyun Ai. Pathway-directed high throughput drug screen identifies PI3K inhibitors that synergistically potentiate anti-tumor activity of HDAC inhibitors in mycosis fungoides and Sezary syndrome. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 388.
Effect of Discontinuities and Penetrations on the Shielding Efficacy of High Temperature Superconducting Magnetic Shields

High Temperature Superconducting (HTS) materials have been demonstrated to be suitable for applications in shielding of both DC and AC magnetic fields. Magnetic shielding is required for protecting sensitive instrumentation from external magnetic fields and for preventing the stray magnetic fields produced by high power density equipment from affecting neighbouring devices. HTS shields have high current densities at relatively high operating temperatures (40-77 K) and can be easily fabricated using commercial HTS conductor. High current densities in HTS materials allow design and fabrication of magnetic shields that are lighter and can be incorporated into the body and skin of high power density devices. HTS shields are particularly attractive for HTS devices because a single cryogenic system can be used for cooling the device and the associated shield. Typical power devices need penetrations for power and signal cabling and the penetrations create discontinuities in HTS shields. Hence it is important to assess the effect of the necessary discontinuities on the efficacy of the shields and the design modifications necessary to accommodate the penetrations.
Resistance to Western Popular and Pop-Culture in India

The essay is designed to present the phenomena of popular culture, its difference from pop culture, both products of modern West, and their impact on film and advertisement media in India. First, the discussion focuses on the Critical School which proposed the initial thesis of commodification of culture with a resultant “lowering” of standards to appeal to “the masses”, and an appeal to the “average” tastes. In the essay an argument is presented that pop culture is a “critique” of popular culture and is an elitist position attempting to shock popular mores and media content. Given this setting, it is argued that while India has followed both the globalizing popular and pop cultures, neither are adequate to encompass Indian media, specifically their film content.
Debating Self-Knowledge

Introduction 1. Brains in a vat Anthony Brueckner 2. Scepticism, objectivity, and brains in vats Gary Ebbs 3. Ebbs on scepticism, objectivity, and brains in vats Anthony Brueckner 4. The dialectical context of Putnam's argument that we are not brains in vats Gary Ebbs 5. Trying to get outside your own skin Anthony Brueckner 6. Can we take our words at face value? Gary Ebbs 7. Is scepticism about self-knowledge incoherent? Anthony Brueckner 8. Is scepticism about self-knowledge coherent? Gary Ebbs 9. The coherence of scepticism about self-knowledge Anthony Brueckner 10. Why scepticism about self-knowledge is self-undermining Gary Ebbs 11. Scepticism about self-knowledge redux Anthony Brueckner 12. Self-knowledge in doubt Gary Ebbs 13. Looking back Anthony Brueckner Bibliography Index.
The usability of unmanned aerial vehicles (UAVs) for measuring park-based physical activity

Abstract While various observation techniques have been developed to measure park use or park-based physical activity, no study has used unmanned aerial vehicles (UAVs) to do so. Thus, this study develops a new observation method that uses UAVs to survey park-based physical activity. This study tests the inter-rater reliability and criterion validity of the UAV-using observation method in comparison to an existing on-the-ground observation tool in five diverse urban parks in Salt Lake City, Utah. With a systematic observation tool, SOPARC (System for Observing Play and Recreation in Communities), this study finds that the UAV observations show a high level of inter-rater reliability (ICC = 0.99 for a total number of users). In addition, compared to the results of on-the-ground observations using SOPARC, those of UAV observations demonstrate validity (ICC = 0.98 for a total number of users). Compared to existing methods, the UAV observation tool, covering larger target areas, is suitable for counting park users in a more reliable and efficient way and mapping their use patterns; however, the tool is weaker at collecting detailed user information and surveying under poor weather conditions. Thus, the UAV method could complement existing tools. Finally, this study suggests practical implications of the UAV observation method.
EXTEMPORANEOUS COMPOUNDING: The End of the Road?

Extemporaneous compounding has long been a part of dermatology. It has served to produce niche therapies that otherwise would have been poorly treated with available drugs. Increasingly however, the unpredictable nature of compounded medications, both in effectiveness, as well as safety and stability of such products, has diminished the use of this approach. The increasing availability of new pharmaceutical drugs that fill these niches more effectively, coupled with economic and legal concerns over the practice of compounding make it a tradition with an increasingly limited role in dermatology today. It is safe to predict that in the near future, compounding will virtually disappear from dermatology, as it already has from virtually all other medical specialties.
Cracking the Chaperone Code: Cellular Roles for Hsp70 Phosphorylation

Heat shock protein 70 (Hsp70) is a molecular chaperone required for protein folding, cell viability, and cancer cell proliferation. Recent studies suggest that Hsp70 phosphorylation regulates important cellular processes, such as cell cycle progression, apoptosis, protein degradation, and resistance to anticancer therapeutics.
Incorporation of integrative medicine education into undergraduate medical education: a longitudinal study

Abstract Objective Integrative medicine (IM) combines complementary medical approaches into conventional medicine and considers the whole person. We implemented a longitudinal IM short-course curriculum into our medical school education. This study aimed to evaluate the feasibility and effectiveness of the curriculum via knowledge and attitude surveys regarding IM among students. Methods A mandatory short IM curriculum across all years of medical school was created and taught by IM professionals and physician faculty members with expertise in integrative therapies. Graduating classes of 2015 and 2016 completed the same survey in their first and third years of medical school. Paired data analysis was done, and only students who completed surveys at both time points were included in final analyses. Results Of 52 students in each class, 17 (33%) in the class of 2015 and 22 (42%) in the class of 2016 completed both surveys. After the IM curriculum, students' knowledge of and comfort with several IM therapies–biofeedback, mindfulness, and the use of St. John's wort–improved significantly. Students' personal health practices also improved, including better sleep, exercise, and stress management for the class of 2015. Students graduating in 2016 reported decreased alcohol use in their third year compared with their first year. Conclusion It is feasible to incorporate IM education into undergraduate medical education, and this is associated with improvement in students' knowledge of IM and personal health practices.
Pathology of Histiocytic Disorders and Neoplasms and Related Disorders

The pathology of histiocytic disorders and neoplasms of the macrophage-dendritic cell lineages is heterogeneous and may have overlapping features, all the while made more difficult by their rarity. The morphologic features together with immunophenotype and pattern of involvement should be taken together with the clinical and radiographic findings to make a unifying diagnosis. The “molecular microscope” of these lesions is further unraveling their biologic potential, which in some cases has helped to solidify their standing as inflammatory myeloid neoplasms. The histopathologic clues for the diagnosis of Langerhans cell histiocytosis (LCH), Erdheim-Chester Disease (ECD), the “juvenile xanthogranuloma” (JXG) family of lesions, Rosai-Dorfman disease (RDD), malignant histiocytoses including histiocytic sarcoma and Langerhans cell sarcoma, and other less common histiocytic-related disorders, including hemophagocytic lymphohistiocytosis (HLH), are reviewed in this chapter.
Wideband LGE MRI permits unobstructed viewing of myocardial scarring in a patient with an MR-conditional subcutaneous implantable cardioverter-defibrillator.

Abstract A subcutaneous implantable cardioverter-defibrillator (S-ICD) is an alternative device for prevention of sudden cardiac death, without any leads within the heart. Patients implanted with any type of ICD may need catheter ablation of ventricular tachycardia (VT) to reduce the overall arrhythmia burden (e.g., recurrent monomorphic VT) and lower the incidence of painful shocks induced by the device. Late gadolinium enhancement (LGE) MRI is a useful pre-test for guiding VT ablation, because it can be used to map myocardial scar and produce better outcomes. Growing evidence suggests that MRI can be performed with manageable risks on patients with a cardiac implantable electronic device (CIED). Nonetheless, the diagnostic yield of cardiac MRI is still low because of severe image artifacts, regardless of MR-conditional or non-MR conditional labeling. Image artifacts in the heart induced by an S-ICD is expected to be larger than the artifacts induced by a transvenous ICD, because the former is twice as large in size and implanted closer to the heart. This is the first reported case of successful wideband LGE MRI in a patient implanted with an MR-conditional S-ICD. A 37-year-old man with ischemic cardiomyopathy was referred for a cardiac MRI at 1.5 T ten months after S-ICD implantation, in order to rule out constrictive pericarditis. Clinical standard LGE MRI produced severe image artifacts, rendering it useless. In contrast, wideband LGE MRI provided unobstructed viewing of myocardial scarring. This case illustrates the usefulness of wideband LGE MRI for assessment of myocardial scarring in a patient with an MR-conditional S-ICD.
Phospholipid Exchange between Membranes

Exchange of phospholipids between serum lipoproteins was described more than 20 years ago by Eder et al. (1954) and by Kunkel and Beam (1954). A few years later, Florsheim and Morton (1957) showed that phospholipid exchange between serum lipoprotein fractions is rapid compared to the disappearance of these lipids from plasma. Exchange of phospholipids between chylomicrons and higher density serum lipoprotein was demonstrated by McCandless and Zilversmit (1958). These studies were extended by Minari and Zilversmit (1963), who showed that the loss of labeled phospholipids from chylomicrons incubated with dog serum was increased greatly when the proportion of serum phospholipid to chylomicron phospholipid was increased approximately tenfold (Fig. 1). In the same study, it was demonstrated that phospholipids exchanged between chylomicrons and serum lipoproteins but that the movement from chylomicrons to serum was greater than that in the reverse direction, thus leading to a net loss of phospholipid from the chylomicron fraction. The relation of this transfer to the removal of chylomicrons from the circulation has been discussed by Zilversmit (1969).
Phase Behavior of H2 + H2O at High Pressures and Low Temperatures

Whereas several clathrate-like structures are known to exist from mixtures of H2 + H2O under pressure, the combined high-pressure and low-temperature region of the phase diagram remains largely unexplored. Here we report a combined Raman spectroscopy and synchrotron X-ray diffraction study on the low-temperature region of the phase diagram. Below ∼120 K, the H2 vibron originating from the clathrate 2 (C2) phase splits into two distinct components, yet X-ray diffraction measurements reveal no structural change between room temperature and 11 K. We suggest that the two vibrons of the C2 phase at low temperature originate from vibrational transitions of hydrogen molecules in the ground and first excited rotational energy levels. At ∼1 GPa we observe the clathrate 1 (C1) phase to persist to the lowest temperature measured (80 K). Upon decompression from the C2 phase we observed the appearance of cubic ice (Ic), which converted to a new phase before transforming to the C1 phase. The structure of the new phase ...
EPR-Derived Structure of a Paramagnetic Intermediate Generated by Biotin Synthase BioB

Biotin (vitamin B7) is an enzyme cofactor required by organisms from all branches of life but synthesized only in microbes and plants. In the final step of biotin biosynthesis, a radical S-adenosyl-l-methionine (SAM) enzyme, biotin synthase (BioB), converts the substrate dethiobiotin to biotin through the stepwise formation of two C-S bonds. Previous electron paramagnetic resonance (EPR) spectroscopic studies identified a semistable intermediate in the formation of the first C-S bond as 9-mercaptodethiobiotin linked to a paramagnetic [2Fe-2S] cluster through one of its bridging sulfides. Herein, we report orientation-selected pulse EPR spectroscopic results that reveal hyperfine interactions between the [2Fe-2S] cluster and a number of magnetic nuclei (e.g., 57Fe, 15N, 13C, and 2H) introduced in a site-specific manner via biosynthetic methods. Combining these results with quantum chemical modeling gives a structural model of the intermediate showing that C6, the target of the second hydrogen-atom abstraction, is now in close proximity to the nascent thioether sulfur and is ideally positioned for the second C-S bond forming event.
The validity of a performance based assessment for aspiring school leaders

This paper introduces the new Massachusetts Performance Assessment for Leaders (PAL) and uses critical policy analysis to re-examine the validity evidence (using the 2014 Standards for Educational and Psychological Testing and a theory of multicultural validity) for the use and interpretation of the PAL in regards to emerging school leadership. Data sources include two years of PAL test documentation plus candidate surveys and interviews with program directors. The author’s role as a test user, faculty instructor, and certified test scorer afforded access to student work, student communications, scorer network training, and state department of education communications and meetings. The paper challenges the content validity, raises questions in regards to evidence based on response processes, internal structure, relation to other variables, consequences, and multicultural validity particularly when the PAL is used as a stand-alone, high-stakes licensure test and offers suggestions to improve the test as a formative assessment.
Compact Wideband Internal Antenna for Sub-60Hz 5G Radios

This paper presents an approach of very compact planar antenna design for integration in 5G mobile phone and laptops. The antenna is designed to cover 5G sub-6GHz high frequency bands. The bands start from 1710 MHz to 6 GHz, it includes LTE high bands, NR and LAA. The antenna design approach and analysis is explained in this study. The impact of feed position, gap between antenna and ground to achieve wider frequency bandwidth is described. The antenna is embedded in the top left corner of the laptop lid to make the study more practical. The lid contains display glass, metal chassis and plastic back cover. The antenna is designed and explained using CST EM-simulator and it has been prototyped and measured. Return loss and efficiency of the antenna is simulated and measured. The antenna is designed over 0.4mm FR4 substrate and it requires only 28mmx8mm area including gap from the ground. It shows better than 6dB returnloss and >40% efficiency over the band starts from 1710MHz to 6GHz. The antenna is well suited for sub-6GHz, 5G high bands for 4×4 MIMO operations.
Progranulin mutations result in impaired processing of prosaposin and reduced glucocerebrosidase activity

Frontotemporal dementia (FTD) is a common neurogenerative disorder characterized by progressive degeneration in the frontal and temporal lobes. Heterozygous mutations in the gene encoding progranulin (PGRN) are a common genetic cause of FTD. Recently, PGRN has emerged as an important regulator of lysosomal function. Here, we examine the impact of PGRN mutations on the processing of full-length prosaposin to individual saposins, which are critical regulators of lysosomal sphingolipid metabolism. Using FTD-PGRN patient-derived cortical neurons differentiated from induced pluripotent stem cells, as well as post-mortem tissue from patients with FTLD-PGRN, we show that PGRN haploinsufficiency results in impaired processing of prosaposin to saposin C, a critical activator of the lysosomal enzyme glucocerebrosidase (GCase). Additionally, we found that PGRN mutant neurons had reduced lysosomal GCase activity, lipid accumulation and increased insoluble α-synuclein relative to isogenic controls. Importantly, reduced GCase activity in PGRN mutant neurons is rescued by treatment with saposin C. Together, these findings suggest that reduced GCase activity due to impaired processing of prosaposin may contribute to pathogenesis of FTD resulting from PGRN mutations.
Insights into Auditor Public Oversight Boards: Whether, How, and Why they 'Work'

We survey 170 inspectors, representing 27% of the inspection staff, from auditor public oversight boards (POBs) in 20 countries to understand whether, how, and why auditors change auditing practices in response to POB oversight. We ask about several theories and areas in the literature. We find that a large majority of POB inspectors believe that auditors frequently respond to inspector feedback by changing audit procedures and quality control systems. Inspectors perceive inspections to have broad effects on several aspects of auditing, ranging from documentation, scrutiny of management estimates, and training to changes in firm culture and even the removal of low-quality partners from public company audit engagements. Inspectors think that the primary reasons why auditors respond to their feedback are 1) POB enforcement capabilities, 2) the perceived authority of the POBs, 3) public disclosure of inspection findings, and 4) that POBs have a culture conducive to detecting auditing deficiencies.
Naloxone-responsive respiratory depression in a patient with a negative urine drug screen

Abstract A 24-year-old male with a history of dizziness and syncope presented to the emergency department via ambulance for the fourth time in 36 hours. His medical history is significant for postural orthostatic tachycardia and factitious disorder. Upon examination in the emergency department, the patient appeared somnolent and displayed shallow, short breaths with occasional apnea. There was a concern for possible opioid overdose prompting admission to the medical intensive care unit. Laboratory testing demonstrated hypercapnic respiratory failure and a negative urine drug screen. Though the patient’s symptoms resolved upon administration of naloxone he denied ingestion of any substances that would contribute to his condition. Previous medical issues had been attributed to misuse of medications prescribed to the patient and loperamide was discovered in his belongings. Testing confirmed the presence of loperamide at supratherapeutic concentrations in his serum.
Prior Sexually Transmitted Infection and Human Immunodeficiency Virus Risk Perception in a Diverse At-Risk Population of Men Who Have Sex with Men and Transgender Individuals.

Prior sexually transmitted infections (STIs) are associated with higher rates of subsequent human immunodeficiency virus (HIV) infection, but the influence of prior STIs on perceived vulnerability ...
Distinguishing active pediatric COVID-19 pneumonia from MIS-C.

Active pediatric COVID-19 pneumonia and MIS-C are two disease processes requiring rapid diagnosis and different treatment protocols. To distinguish active pediatric COVID-19 pneumonia and MIS-C using presenting signs and symptoms, patient characteristics, and laboratory values. Patients diagnosed and hospitalized with active COVID-19 pneumonia or MIS-C at Children’s of Alabama Hospital in Birmingham, AL from April 1 through September 1, 2020 were identified retrospectively. Active COVID-19 and MIS-C cases were defined using diagnostic codes and verified for accuracy using current US Centers for Disease Control case definitions. All clinical notes were reviewed for documentation of COVID-19 pneumonia or MIS-C, and clinical notes and electronic medical records were reviewed for patient demographics, presenting signs and symptoms, prior exposure to or testing for the SARS-CoV-2 virus, laboratory data, imaging, treatment modalities and response to treatment. 111 patients were identified, with 74 classified as mild COVID-19, 8 patients as moderate COVID-19, 8 patients as severe COVID-19, 10 as mild MIS-C and 11 as severe MIS-C. All groups had a male predominance, with Black and Hispanic patients overrepresented as compared to the demographics of Alabama. Most MIS-C patients were healthy at baseline, with most COVID-19 patients having at least one underlying illness. Fever, rash, conjunctivitis, and gastrointestinal symptoms were predominant in the MIS-C population whereas COVID-19 patients presented with predominantly respiratory symptoms. The two groups were similar in duration of symptomatic prodrome and exposure history to the SARS-CoV-2 virus, but MIS-C patients had a longer duration between presentation and exposure history. COVID-19 patients were more likely to have a positive SAR-CoV-2 PCR and to require respiratory support on admission. MIS-C patients had lower sodium levels, higher levels of C-reactive protein, erythrocyte sedimentation rate, d-dimer and procalcitonin. COVID-19 patients had higher lactate dehydrogenase levels on admission. MIS-C patients had coronary artery changes on echocardiography more often than COVID-19 patients. This study is one of the first to directly compare COVID-19 and MIS-C in the pediatric population. The significant differences found between symptoms at presentation, demographics, and laboratory findings will aide health-care providers in distinguishing the two disease entities.
Moisture Mode Theory’s Contribution to Advances in our Understanding of the Madden-Julian Oscillation and Other Tropical Disturbances

Our understanding of the Madden-Julian Oscillation (MJO) and other tropical motion systems has significantly improved in recent years. This article reviews the contribution of moisture mode theory to this progress. Two realizations have contributed significantly to our understanding of the MJO: (1) Free tropospheric water vapor plays an important role in the occurrence and organization of tropical deep convection. (2) The latent heat released in convection is quickly transported around the tropics by gravity waves, the physical mechanism underpinning the weak temperature gradient (WTG) approximation. Simple models of the tropics that include (1) and (2) revealed the existence of moisture modes, waves in which water vapor plays a dominant role in their evolution. It was soon recognized that the MJO exhibits properties of moisture modes. The ensuing development and application of the so-called moisture mode theory of the MJO have led to the recognition that horizontal and vertical moisture advections are central to the propagation of the MJO, and that cloud-radiative heating is at least partially responsible for its maintenance. Moisture mode theory has also been applied to understand the MJO’s seasonality, Maritime Continent transit, and response to increasing CO2. Recent work suggests that moisture mode theory can be extended beyond the MJO in order to explain the observed diversity of tropical motion systems. A mounting body of evidence indicates that the MJO has properties of moisture modes. Extension of the theory beyond the MJO may help us further understand the processes that drive large-scale tropical circulations.
Swahili Poetry’s Digital Geographies: WhatsApp and the Forming of Cultural Space

As the availability of web-enabled mobile devices and internet access have sky-rocketed in East Africa in the last decade and a half, so too have digital media played an increasing role in the composition, circulation, and consumption of literary texts. One striking example is the burgeoning Majagina wa Ushairi poetry group on the digital messaging platform WhatsApp. Considering the strict formal rules established by the group’s administrators, and attending closely to a few of the poems and poetic dialogues circulated within the group in the last two years, I argue that the use of group messaging features by members of the Majagina wa Ushairi group serves not only to establish or augment a network of poets writing in Swahili across East Africa and the diaspora, but to form (and defend) a new space for an idealized Swahili cultural identity grounded in poetic dialogue. While poetic discourse on the platform reveals utopic post-territorial aspirations among the members, the group also evinces competing and gendered geographies of literary production and performance, revealing an entanglement between the boundaries of poetic form and the boundaries of social and cultural space.
The Impact of Technical Interviews, and other Professional and Cultural Experiences on Students' Computing Identity

Increasingly companies assess a computing candidate's capabilities using technical interviews (TIs). Yet students struggle to code on demand, and there is already an insufficient amount of computing graduates to meet industry needs. Therefore, it is important to understand students' perceptions of TIs, and other professional experiences (e.g., computing jobs). We surveyed 740 undergraduate computing students at three universities to examine their experiences with the hiring process, as well as the impact of professional and cultural experiences (e.g., familial support) on computing identity. We considered the interactions between these experiences and social identity for groups underrepresented in computing - women, Black/African American, and Hispanic/Latinx students. Among other findings, we observed that students that did not have positive experiences with TIs had a reduced computing identity, but that facing discrimination during technical interviews had the opposite effect. Social support may play a role. Having friends in computing bolsters computing identity for Hispanic/Latinx students, as does a supportive home environment for women. Also, freelance computing jobs increase computing identity for Black/African American students. Our findings are intended to raise awareness of the best way for educators to help diverse groups of students to succeed, and to inform them of the experiences that may influence students' engagement, resilience, and computing identity development.
Digital Engineering of Large Scale System of Systems: End-to-End (E2E) Modeling and Analysis Environment

The US Department of Defense (DoD) has increasingly expanded their focus beyond systems to address the application of systems engineering approaches to ‘missions’. Mission Engineering (ME) is defined in the Defense Acquisition Guidebook as: “the deliberate planning, analyzing, organizing, and integrating of current and emerging operational and system capabilities to achieve desired operational mission effects”. At the same time, in the DoD Digital Engineering Strategy, the DoD has emphasized the transformation of systems engineering into a digital, model-based discipline. Bringing these two together, there is strong interest in the development and application of Digital Engineering Environments (DEE) to address mission level systems of systems (SoS) requirements, analysis, engineering, and portfolio management. This paper provides an approach to applying Digital Engineering (DE) to a large system of systems mission [1].
IgG4 Related Disease is characterized by the overexpression of Immunomodulatory proteins.

Introduction IgG4 related disease (IgG4-RD) is a multisystem disease, characterized by tumefactive lesions and a swift response to immunosuppressive therapy. Although elevated serum and tissue IgG4 are characteristic, T-cells appear to be the primary driver of this immunologically mediated disease. The overarching goal was to examine the role of immunomodulatory cells in IgG4-RD. Methods Biopsies from patients with IgG4-RD (n=39) and mimics of this disease (n=78) were evaluated for IgG4, IgG, CD8, PD-L1 and a subset (n=18) evaluated for CD4, PU.1, Foxp3, PD-L1, PD-1, IDO1 and LAG3. Data pertaining to demographics and laboratory findings at baseline evaluation was extracted from electronic medical records. Results When compared to mimics, IgG4-RD showed increased numbers of PD-L1 (p=0.0001), PD-1 (p=0.001), IDO1 (p=0.03), LAG3 (p=0.04) and Foxp3 (p=0.04) positive immune cells. The PD-L1 positive cells were enriched within aggregates of CD4 and CD8 positive T-cells. 31 of 39 (80%) IgG4-RD cases showed greater than 5 PD-L1 positive cells per HPF, while 4 of 78 (5%) mimics of this disease exceeded this cut point. In IgG4-RD PD-L1 positive macrophages correlated with PD-1 (p=0.002), LAG3 (p=0.001) and IDO1 positive cells (p=0.001); a positive correlation was also noted between IgG4/IgG ratio and PD-L1, PD-1, and IDO1 positive cells. Conclusions IgG4-RD shows expansion of mechanisms that maintain peripheral tolerance. The spatial and temporal relationship between T-cells and the PD-L1-PD1 axis, and the upregulation of multiple immunomodulatory proteins suggests that these immunoregulatory mechanisms play a significant role in IgG4-RD.
Doubly-ionized lanthanum as a qubit candidate for quantum networks

We propose doubly-ionized lanthanum (La$^{2+}$) as a possible qubit candidate for quantum networks. Transitions between the lowest levels in the atom are in the infrared, enabling a direct matter-light interface amenable to long-distance quantum communication. These transitions could also be used to directly laser-cool trapped La$^{2+}$ ions. The rich hyperfine structure of the ion may allow for a qubit stored in magnetic-field insensitive states, as well as protocols for atom-photon entanglement.
Thermal emission of Saturn's rings and disk at 34 µm

The relative thermal emission from the rings and disk of Saturn in the band from 29 to 43 micrometers has been measured with the aid of ground-based observations in which new filter techniques were used. The new data provide an important constraint for separating the thermal properties of Saturn from those of its rings. The results reported support previous suggestions of a large internal heat source for Saturn.
Fibrilhação auricular num ACeS da Região Norte - sua prevalência e proporção de terapêuticas antitrombóticas

Objectives: To determine the prevalence of atrial fibrillation among patients in primary health care clinics in West Porto in May 2013, to assess the distribution of CHA2DS2VASc risk factors for thromboembolism, to study antithrombotic therapy and the sites where anticoagulation therapy is managed. Type of Study: Cross-sectional study. Setting: Primary Health Care Centres of West Porto. Population: Patients registered in the health units of West Porto. Methods: Data were collected from the electronic medical records using SIARS, MIM@UF and SAM software. The chi-squared statistic was used for comparison of proportions, with statistical significance set at the p < 0.05 level. Results: The authors identified 1628 people with atrial fibrillation. Of these 58% were female. They ranged in age from 29 to 104 years with a mean age of 76 ± 11 years. The prevalence of atrial fibrillation was 0.98%, with a prevalence of 1.77% in patients over 39 years. The CHA2DS2VASc score was greater than zero in 95% of patients, excluding cases where female gender was the only risk factor. The main risk factors were arterial hypertension (75%), age greater than 74 years (62%) and female gender. Anticoagulation therapy was prescribed to 68% of patients with 88% receiving vitamin K antagonists. Follow-up of anticoagulation was performed in clinical laboratories in 74% of cases. Conclusions: The prevalence of atrial fibrillation in this population was greater than that reported in a national study in 2006 (0.5%). However the prevalence in patients over 39 years of age was less than that found in a study conducted in 2010, using electrocardiographic diagnosis (2.5%). Identification of patients with atrial fibrillation is an important task in primary health care.
The perturbed structure of the neutral atmospheric boundary layer over irregular terrain

The differential equations for first-order (linear) response of the planetary boundary layer are formulated for flow over periodic terrain, for variations in both surface roughness and terrain elevation. A simple second-order closure model of the turbulence is used, and Coriolis forces are neglected. Flow over a periodic terrain produces corresponding periodic structure in all meteorological fields above the surface. The periodic structure consists of two components. The first is very nearly evanescent with height. It corresponds to the motion that would be observed were the atmosphere inviscid. The second component, introduced by turbulent viscosity, exhibits a phase variation with height in addition to a decay in amplitude. W.K.B. [Wentzel-Kramers-Brillouin] approximations for the two components are developed, and the coupling between the components is discussed. The formulation for calculating solutions by numerical integration is developed, including specification of appropriate boundary conditions. Calculations are presented in a companion paper.