cssi/SciSciGPT-SciSciNet huggingface dataset:
Choice and Doses of Antibacterial Agents for Cement Spacers in Treatment of Prosthetic Joint Infections: Review of Published Studies

Background. Addition of antibacterial drugs to interim antibacterial cement spacers (ACSs) is considered to be standard of care for surgical revision in prosthetic joint infections (PJIs). We reviewed published studies evaluating the choice and doses of antibacterials in spacers. Methods. We conducted a PubMed search of all clinical study reports evaluating the use of ACSS in a 2-stage hip or knee arthroplasty for treatment of PJI (1988 through August 2011). The trial design, antibacterials used, and end points studied were analyzed. Results. No randomized trials were found comparing either ACSs with different concentrations of antibacterials or ACSs with or without antibacterials. Most of the studies were uncontrolled and used various time points to evaluate the outcome. Twenty publications that reported doses of antibacterials in spacers and had a follow-up of ≥24 months after the second stage were selected for review. Most ACSs included vancomycin and aminoglycosides. The doses of aminoglycosides and vancomycin ranged from 0.25 to 4.8 g and from 1 to 4 g, respectively, per 40 g of cement. No association between reported eradication of the infection and antibacterial load was found. Conclusions. Published data do not allow evaluation of whether antibacterials in temporary cement spacers provide additional benefits in the treatment of PJI, compared with systemic antibacterials, and are not sufficient to support recommendations on dosages. Complications of ACSs have not been consistently analyzed. Prospective randomized trials comparing spacers with and without antibacterials or spacers with different loads of antibacterials are needed to evaluate the safety and efficacy of ACSs.
Vulnerability of Structures to Weapons Effects

The Geotechnical and Structures Laboratory (GSL) has a number of funded research efforts to support Department of Defense (DoD) requirements for understanding the response of structures to explosives/weapons. These efforts are all heavily dependent on high performance computing (HPC) simulations to meet research needs. The research efforts to be supported include Force Protection, Military Operations in Urban Terrain, and Homeland Defense. HPC simulations are used to enhance ongoing experimental programs. The simulations are used to assist in designing experiments, to aid in understanding the experiments, to extend the knowledge beyond the limitations of the experiments, and to develop numerical databases. High priority HPC hours available through the High Performance Computing Modernization Program (HPCMP) Challenge Project were used to perform these simulations. Simulation results are compared with experimental results when available.
Diffraction gratings and geometrical optics

We show that diffraction gratings can be naturally placed in the framework of geometrical optics. In this context, the relationship between path length and group delay, τ(ω) = l(ω)/c, is a straightforward result of Fermat’s principle. This result eases some of the conceptual difficulties involved in the analysis of grating-pair pulse compressors. Our method is equally applicable to both phase and amplitude gratings.
Variability in FMRP and Early Development in Males With Fragile X Syndrome

To test the hypothesis that variability in development in fragile X syndrome is related to FMRP (the protein deficient in this syndrome expression), we studied 53 males between 23 and 98 months of age. For the entire group, which included males with either mosaism, partially methylated full mutation, and fully methylated full mutation, FMRP expression ranged from 1% to 40% and accounted for a small but significant amount of variance in level, but not rate, of total development as well as motor, social, adaptive, cognitive, and language development. For males with a fully methylated full mutation, the association was in the hypothesized direction, but not statistically significant. Findings support the hypothesized relationship between FMRP and individual capabilities but suggest that other factors also play a major role.
The Role of Naming in Stimulus Categorization by Preschool Children.

The purpose of the current study was to assess whether children would categorize pictures when taught the relevant listener and speaker behaviors separately. A category-sort test was used to assess emergent conditional relations. Category-sort trials consisted of looking at (Test 1) or tacting/labeling (Test 2) a sample stimulus and selecting the appropriate comparison stimuli. In Experiment 1, 4 children (3-5 years) were taught to tact pictures of six U.S. state maps as either north or south. An assessment was conducted to determine whether they would (1) correctly categorize or sort when presented with a visual sample and (2) select the correct stimuli when hearing their category names (listener behavior). Two of the children categorized the pictures during Posttest 1 after the initial (pairwise) tact training. The other 2 categorized after receiving additional tact training with all pictures presented together. However, one of them categorized only during Posttest 2. In Experiment 2, 4 children (3-5 years) were taught to select pictures when hearing their category names. An assessment was conducted to determine whether they would (1) correctly categorize or sort and (2) tact the stimuli (speaker behavior). One child categorized the pictures during Posttest 1, and two during Posttest 2. The other child required additional training with all pictures grouped together. When participants failed to categorize, they also failed to tact the pictures accurately. Taken together, results from Experiments 1 and 2 show that both speaker and listener behavior play an important role in stimulus categorization.
Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin

Cutaneous vasoconstriction (VC) is the initial thermoregulatory response to cold exposure and can be elicited through either whole body or localized skin cooling. However, the mechanisms governing ...
TCP vs. TCP: a systematic study of adverse impact of short-lived TCP flows on long-lived TCP flows

This paper describes systematical development of TCP adversarial scenarios where we use short-lived TCP flows to adversely influence long-lived TCP flows. Our scenarios are interesting since, (a) they point out the increased vulnerabilities of recently proposed scheduling, AQM and routing techniques that further favor short-lived TCP flows and (b) they are more difficult to detect when intentionally found to target long-lived TCP flows. We systematically exploit the ability of TCP flows in slow-start to rapidly capture greater proportion of bandwidth compared to long-lived TCP flows in congestion avoidance phase, to a point where they drive long-lived TCP flows into timeout. We use simulations, analysis and experiments to systematically study the dependence of the severity of impact on long-lived TCP flows on key parameters of short-lived TCP flows-including their locations, durations and numbers, as well as the intervals between consecutive flows. We derive characteristics of pattern of short-lived flows that exhibit extreme adverse impact on long-lived TCP flows. Counter to common beliefs, we show that targeting bottleneck links does not always cause maximal performance degradation for the long-lived flows. In particular, our approach illustrates the interactions between TCP flows and multiple bottleneck links and their sensitivities to correlated losses in the absence of 'non-TCP friendly' flows and paves the way for a systematic synthesis of worst-case congestion scenarios. While randomly generated sequences of short-lived TCP flows may provide some reductions (up to 10%) in the throughput of the long-lived flows, the scenarios we generate cause much greater reductions (>85%) for several TCP variants and for different packet drop policies (DropTail, RED).
Histology, Cytology, and Size of the Parathyroid in Bovine Related to Age and Function

Abstract The weight of bovine parathyroids, along with the histological and cytological changes that occur in them throughout lactation and the reproductive cycle, have been studied. Results indicate that there are cyclic changes that occur in the activity of the parathyroid which correspond with the annual mineral metabolism cycle of the dairy cow. During heavy lactation, the glands are depressed in secretory activity, as indicated by their smaller size. The tissue is composed of small chromophilic cells containing massive aggregations of sudanophilic granules and vesicles. A gradual change occurs after mid-lactation to increase gland size. Deposition of fatty tissue within the gland capsule and a change in cytology to cells (principal cells) devoid of the aggregated sudanophilic granules and vesicles is evident. Just prior to parturition the parathyroids show evidence of the greatest secretory activity. The tissue hypertrophies, resulting in larger glands composed of large clear cells.
p53CP is p51/p63, the third member of the p53 gene family: partial purification and characterization

The p53 tumor suppressor is a transcription factor that upon activation by DNA-damaging agents induces growth arrest or apoptosis mainly through transactivation and transrepression of its downstream target genes. Two additional p53 family members, p73 and p51/p63, were recently identified and characterized. Although the three family members share some similarities in transcription activation and apoptosis induction, each of them appears to play a distinct role in development and tumor suppression. We have previously identified a nuclear protein, p53CP (p53 competing protein), that is not p53 but binds to the p53 consensus sequence. Here we report the partial purification of p53CP from HeLa cells by ammonium sulfate precipitation, followed by a series of chromatography steps through heparin-agarose, Mono S ion exchange and DNA affinity columns, coupled with a gel shift assay. Although p53CP activity is readily detectable in HeLa cells by gel shift assay, only a trace amount of p53CP protein was partially purified, which was not sufficient for direct protein sequencing. Using a monoclonal antibody (4A4) specific for all p51/p63 isoforms or a polyclonal antibody (N-18) recognizing the N-terminus-containing p51/p63 isoforms we detected a significant enrichment of p51/p63 protein in p53CP-containing fractions following each step of purification. Significantly, p51/p63 was detected only in the DNA affinity column fractions that contain p53CP activity. Thus, p53CP appears to be p51/p63, the third member of the p53 gene family.
Designing Interactions for Robot Active Learners

This paper addresses some of the problems that arise when applying active learning to the context of human-robot interaction (HRI). Active learning is an attractive strategy for robot learners because it has the potential to improve the accuracy and the speed of learning, but it can cause issues from an interaction perspective. Here we present three interaction modes that enable a robot to use active learning queries. The three modes differ in when they make queries: the first makes a query every turn, the second makes a query only under certain conditions, and the third makes a query only when explicitly requested by the teacher. We conduct an experiment in which 24 human subjects teach concepts to our upper-torso humanoid robot, Simon, in each interaction mode, and we compare these modes against a baseline mode using only passive supervised learning. We report results from both a learning and an interaction perspective. The data show that the three modes using active learning are preferable to the mode using passive supervised learning both in terms of performance and human subject preference, but each mode has advantages and disadvantages. Based on our results, we lay out several guidelines that can inform the design of future robotic systems that use active learning in an HRI setting.
Metabolism of Arachidonic Acid in Inflamed Human Gingivae. I.: Formation of 6-Keto-prostaglandin F1α:

Incubation of [14 C]-arachidonic acid with slices of inflamed human gingivae in the absence of glutathione resulted in formation of 6-keto-PGF1α, the stable hydrolytic product of prostacyclin. Significantly smaller amounts of this product were obtained when normal gingivae were treated in a similar manner. The formation of prostacyclin in inflamed gingivae may play an important role in alveolar bone resorption and as a mediator of inflammation in periodontal disease.
Current Options for the Topical Treatment of Acne Vulgaris

The etiopathogenesis of acne vulgaris, a common disorder of youth and adolescence, includes four primary processes: hyperkeratinization (plugging) of the pilosebacous follicles, increased testosterone levels, bacterial colonization with Propionibacterium acnes, and inflammation. No single agent has yet been developed that addresses all of these factors. Combination regimens, therefore, which usually include an antibiotic and an agent to reduce follicular plugging, have become the mainstay of treatment. Despite a relative dearth of new treatments for almost a decade, recent research has produced a number of new significant oral and topical agents. Azelaic acid, a naturally occurring dicarboxylic acid analogue, has shown promise, and a group of retinoids that include adapalene, tazarotene, and reformulations of tretinoin represent new and forthcoming agents for topical treatment of acne vulgaris. Some studies indicate that several of these agents are associated with less skin irritation than previous formulations while they retain potent comedolytic activity. Adapalene also possesses significant anti-inflammatory activity.
Covering the Uninsured: How Much Would It Cost?

To evaluate the costs of providing insurance coverage to the uninsured, this study presents two sets of estimates derived from medical spending patterns of lower-middle income people with private insurance plans and of people with public insurance coverage during 1996?1998. The analysis suggests that the uninsured would use between $33.9 and $68.7 billion (in 2001 dollars) in additional medical care if they were fully insured. An increase in medical spending of this range would increase total health care spending by 3 to 6 percent, and increase health care's share of GDP by less than one percentage point. (Health Affairs Web Exclusive, June 4, 2003.)
Mechanism of action of Escherichia coli exonuclease III

Exonuclease III is the major apurinic/apyrimidinic (AP) endonuclease of Escherichia coli, accounting for more than 80% of the total cellular AP endonuclease activity. We have shown earlier that the endonucleolytic activity of exonuclease III is able to hydrolyze the phosphodiester bond 5' to the urea N-glycoside in a duplex DNA [Kow, Y. W., & Wallace, S. S. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 8354-8358]. Therefore, we were interested in studying the mechanism of action of the endonucleolytic activity of exonuclease III by preparing DNA containing different base lesions as well as chemically modified AP sites. When AP sites were converted to O-alkylhydroxylamine residues, exonuclease III was able to hydrolyze the phosphodiester bond 5' to O-alkylhydroxylamine residues. The apparent Km for different O-alkylhydroxylamine residues was not affected by the particular O-alkylhydroxylamine residue substituted; however, the apparent Vmax decreased as the size of the residue increased. On the basis of a study of the substrate specificity of exonuclease III, a modification of the Weiss model for the mechanism of action of exonuclease III is presented. Furthermore, a temperature study of exonucleolytic activity of exonuclease III in the presence of Mg2+ showed discontinuity in the Arrhenius plot. However, no discontinuity was observed when the reaction was performed in the presence of Ca2+. Similarly, no discontinuity was observed for the endonucleolytic activity of exonuclease III, in the presence of either Ca2+ or Mg2+. These data suggest that, in the presence of Mg2+, exonuclease III, in the presence of either Ca2+ or Mg2+.(ABSTRACT TRUNCATED AT 250 WORDS)
Multidimensional Variation in an Avian Display: Implications for Social Communication

An analysis of song-spread displays performed in social communication by carib grackles, Quiscalus lugubris, revealed that two components of this motor coordination. beak elevation and wing elevati...
Architecture and compiler tradeoffs for a long instruction wordprocessor

A very long instruction word (VLIW) processor exploits parallelism by controlling multiple operations in a single instruction word. This paper describes the architecture and compiler tradeoffs in the design of iWarp, a VLIW single-chip microprocessor developed in a joint project with Intel Corp. The iWarp processor is capable of specifying up to nine operations in an instruction word and has a peak performance of 20 million floating-point operations and 20 million integer operations per second. An optimizing compiler has been constructed and used as a tool to evaluate the different architectural proposals in the development of iWarp. We present here the analysis and compiler optimizations for those architectural features that address two key issues in the design of a VLIW microprocessor: code density and a streamlined execution cycle. We support the results of our analysis with performance data for the Livermore Loops and a selection of programs from the LINPACK library.
‘Til Eph Do Us Part’: Intercellular Signaling via Eph Receptors and Ephrin Ligands Guides Cerebral Cortical Development from Birth Through Maturation

Eph receptors, the largest family of surface-bound receptor tyrosine kinases and their ligands, the ephrins, mediate a wide variety of cellular interactions in most organ systems throughout both development and maturity. In the forming cerebral cortex, Eph family members are broadly and dynamically expressed in particular sets of cortical cells at discrete times. Here, we review the known functions of Eph-mediated intercellular signaling in the generation of progenitors, the migration of maturing cells, the differentiation of neurons, the formation of functional connections, and the choice between life and death during corticogenesis. In synthesizing these results, we posit a signaling paradigm in which cortical cells maintain a life history of Eph-mediated intercellular interactions that guides subsequent cellular decision-making.
Girl game designers

Educational programs designed to bridge the digital divide for girls often aim to increase girls’ technological literacy. However, little research has examined what aspects of technological literacy are highlighted in these programs. In this article, I provide a case study of a video game design workshop hosted by a girls’ advocacy organization. Through observations, interviews, and analysis of program materials, I look at how the organization conceptualizes technological literacy as contributing to gender equality. I compare this conceptualization to how technological literacy was taught in the classroom. Finally, I draw on situated learning theory to help explain how girls responded to the class. In the end, both the organization’s limited notion of how technological literacy could increase gender equality as well as gender and race differences between the teachers and the girls influenced girls’ participation in the workshop.
Cross-Sensor Continuity of Satellite-Derived Water Clarity in the Gulf of Mexico: Insights Into Temporal Aliasing and Implications for Long-Term Water Clarity Assessment

Addressing critical earth science questions often requires time scales beyond the life of any single satellite sensor. Overlap between satellite-based datasets allows for the quantification of continuity (and discrepancies) between sensors. Toward that end, collocated matchups between Sea-viewing Wide Field-of-View Sensor (SeaWiFS), Moderate Resolution Imaging Spectroradiometer (MODIS), and Visible Infrared Imager Radiometer Suite (VIIRS) water clarity data from the Gulf of Mexico were analyzed at simultaneous, daily, and monthly time scales. Simultaneous data indicated strong agreement between sensors, with unbiased percent difference (UPD) generally less than 10% for both SeaWiFS/MODIS and VIIRS/MODIS matchups, with no apparent temporal trends. Spatially, UPD was highest near frontal boundaries and at high sensor zenith angles, while bias showed nearshore/offshore trends. UPD and bias statistics did not diminish for daily matchups; however, large degradation was seen for comparisons of monthly means between sensors, particularly SeaWiFS/MODIS matchups. Data coverage represented an important factor contributing to uncertainties in monthly mean data, as higher UPD was observed when fewer valid satellite measurements were recorded. Requiring a minimum of 15 samples per pixel per month minimizes the uncertainties in monthly mean products, with UPD between satellites roughly equivalent to that for simultaneous matchups. Overall, these findings demonstrate high consistency between three satellite instruments for most locations, while several “hot spots” of inconsistency are also revealed, which should be avoided in time-series studies. The findings also highlight the need to quantify uncertainties in often-used satellite products (particularly monthly mean composites) as well as the need to have a sufficient number of observations to assure the fidelity of monthly means.
Upregulation of BST-2/tetherin by HIV infection in vivo

The interferon-inducible antiviral factor BST-2 prevents several enveloped viruses, including HIV, from escaping infected cells. The HIV protein Vpu antagonizes this host defense. Little is known about the expression of BST-2 during HIV infection in vivo and whether it can be modulated to the host's advantage. We studied the expression of BST-2 on blood cells from HIV-infected patients during the acute and chronic phases of disease as well as after antiretroviral treatment (ART). The expression of BST-2 was increased on mononuclear leukocytes, including CD4-positive T lymphocytes from HIV-positive patients, compared to that on cells of uninfected controls. The expression of BST-2 was highest during acute infection and decreased to levels similar to those of uninfected individuals after ART. Treatment of primary blood mononuclear cells in vitro with alpha interferon or with Toll-like receptor (TLR) agonists increased the expression of BST-2 to levels similar to those found during infection in vivo. The interferon-induced levels were sufficient to overcome the Vpu protein in vitro, reducing the release of wild-type HIV. These data show that BST-2 is upregulated during HIV infection, consistent with its role as an interferon-stimulated gene. The data further suggest that this upregulation is sufficient to saturate the activity of Vpu and inhibit wild-type HIV.
Civil Rights and Writing Assessment: Using the Disparate Impact Approach as a Fairness Methodology to Determine Social Impact

The Civil Rights Act of 1964 has served as an influential legal framework for addressing intentional (disparate treatment) and unintentional (disparate impact) discrimination. While philosophical and methodological discussions of Title VI and Title VII are well articulated in the legal scholarship, the disparate impact approach — a method for determining unintended racial differences in outcomes resulting from facially neutral policies or practices — remains an underutilized conceptual and methodological framework in the assessment literature. In this article, we argue that the burden-shifting heuristic used by entities such as the Office for Civil Rights to redress disparate impact is a valuable approach in determining fairness of writing assessment practices. In demonstrating an application of the burden-shifting approach at one university writing program, we discuss the value of the proposed integrative framework as well as point to remaining questions regarding sampling concerns — group identification, group stability, and intersectionality.
Issues of gustatory neural coding: Where they stand today

The basic issues of gustatory neural coding are revisited. Questions addressed and conclusions drawn are: (1) what is the physical dimension across which gustatory neurons are sensitive, and upon which taste perceptions are based? The dimension that unites the various taste qualities is not physical, but physiological: a dimension of well-being, bounded by toxins at one extreme and nutrients at the other. (2) How broadly tuned are taste cells across the dimension? There are instances of specificity, but most mammalian taste cells respond to a range of qualities. (3) Are there basic taste qualities? Sweet, salty, sour, and bitter are widely accepted as basic tastes. Umami and starch tastes are considered basic by some. (4) Is taste topographically organized? There is some degree of physical separation among neurons most responsive to different taste qualities, but this does not appear to be sufficient precision to act as a meaningful coding mechanism. (5) Are there gustatory neuron types? Neurons, separated into categories according to their response profiles, respond as members of their category to the challenges of conditioned aversions and preferences, sodium deprivation, hyperglycemia, and receptor blockade, while cells from other categories react differently. This indicates the existence of functionally distinct types of taste cells. (6) Is the quality signal coded within the activity of the single most appropriate category of neurons, or is it carried by the pattern of response across neuronal categories? Both the breadth of responsiveness and the logical ambiguity of the signal in any one category of neurons argue that the taste message is carried by a pattern of activity across gustatory neuron types.
On a Coefficient Conjecture of Brannan

In 1972. D.A. Branna conjectured that all of the odd coefficients, a 2n+1 of the power series (1+xz)α/(1-z) were dominated by those of the series (1 + z)α(1-z) for the parameter range 0 < α < 1 after having shown that this was not true for the even coefficients. He verified the case when 2n + 1 = 3 The case when 2n + 1 = 5 was verified in the mid-eighties by J. G. Milcetich. In this paper, we verify the case when 2n + l = 7 using classical Sturm sequence arguments and some computer algebra.
Hypothetical Bias Mitigation in Choice Experiments: Effectiveness of Cheap Talk and Honesty Priming Fade with Repeated Choices

We design a choice experiment comparing policies that reduce agricultural nutrient pollution and harmful algal blooms in Lake Erie and administer it to Ohio residents using an online survey panel. We compare two treatments that have been found to mitigate hypothetical bias, cheap talk and honesty priming. We find greater sensitivity to price among respondents during choices made immediately following the cheap talk intervention. As additional choices are made, price sensitivity diminishes and eventually matches that of respondents in the control treatment. We find this effect in both our online choice experiments and among respondents to face-to-face choice experiments conducted by de-Magistris, Gracia and Nayga (2013, DNG). Our online implementation of an honesty priming intervention yields no significant change in price sensitivity compared to a control. While DGN (2013) implement an honesty priming intervention that fully mitigates hypothetical bias in a face-to-face setting, we show this effect is also transient, and in later choice exercises we cannot reject the null hypothesis of equality between honesty priming and the control. Our results suggest additional work is required to adapt priming interventions for online settings and to extend the effectiveness of popular hypothetical bias mitigation techniques when respondents face multiple choice tasks.
Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro.

Dendritic cells (DCs) genetically modified to continually express and present antigens may be potent physiologic adjuvants for induction of prophylactic or therapeutic immunity. We have previously shown that an env and nef deleted HIV-1 vector (HIV-1ΔEN) pseudotyped with VSV-G transduced monocyte-derived macrophages as well as CD34+ precursors of DCs. Here we extended these findings with HIV-1ΔEN to highly differentiated human DCs derived in culture from circulating monocytes (DCs). In addition, a new vector derived from HIV-1ΔEN but further deleted in its remaining accessory genes vif , vpr, and vpu (HIV-1ΔEN V3) was also tested. Both vectors efficiently transduced DCs. Transduction of DCs did not significantly alter their viability or their immunophenotype when compared with untransduced DCs. Furthermore, the phagocytic potential of immature DCs, as well as their ability to differentiate into mature DCs capable of stimulating T-cell proliferation, was not affected. Finally, DCs transduced by the HIV-1ΔEN vector were able to elicit a primary antiviral cytotoxic T-cell response in autologous CD8 T cells. These results suggest that HIV-1–based vectors expressing viral antigens may be useful for in vivo active immunization as well as ex vivo priming of cytotoxic T cells for adoptive T-cell therapy.
Comparison of Pulse-Burst PIV Data to Simultaneous Conventional PIV Data

Time-resolved particle image velocimetry (PIV) using a pulse-burst laser has been acquired of a supersonic jet issuing into a Mach 0.8 crossflow. Simultaneously, the final pulse pair in each burst has been imaged using conventional PIV cameras to produce an independent two-component measurement and two stereoscopic measurements. Each measurement depicts generally similar flowfield features with vorticity contours marking turbulent eddies at corresponding locations. Probability density functions of the velocity fluctuations are essentially indistinguishable but the precision uncertainty estimated using correlation statistics shows that the pulse-burst PIV data have notably greater uncertainty than the three conventional measurements. This occurs due to greater noise in the cameras and a smaller size for the final iteration of the interrogation window. A small degree of peak locking is observed in the aggregate of the pulse-burst PIV data set. However, some of the individual vector fields show peak locking to non-integer pixel values as a result of real physical effects in the flow. Even if peak locking results entirely from measurement bias, the effect occurs at too low a level to anticipate a significant effect on data analysis.
Save Water To Save Carbon and Money: Developing Abatement Costs for Expanded Greenhouse Gas Reduction Portfolios

The water–energy nexus is of growing interest for researchers and policy makers because the two critical resources are interdependent. Their provision and consumption contribute to climate change through the release of greenhouse gases (GHGs). This research considers the potential for conserving both energy and water resources by measuring the life-cycle economic efficiency of greenhouse gas reductions through the water loss control technologies of pressure management and leak management. These costs are compared to other GHG abatement technologies: lighting, building insulation, electricity generation, and passenger transportation. Each cost is calculated using a bottom-up approach where regional and temporal variations for three different California water utilities are applied to all alternatives. The costs and abatement potential for each technology are displayed on an environmental abatement cost curve. The results reveal that water loss control can reduce GHGs at lower cost than other technologies an...
Disorienting guitar practice: an alternative archive

ABSTRACTThis paper critically examines the gendering of electric guitar technique in its limited scholarly reception. Focus is given to the work of Steve Waksman, specifically the “technophallus,” a coinage through which he engages feminist scholarship to interrogate the electric guitar's masculine performative identity. This paper offers a counter-archive of punk guitarists whose work, when approached with a queer analytic, problematize the pairing of virtuosity with heteromasculinity. Synthesizing the work of Jose Esteban Munoz and Jack Halberstam on queer failure and virtuosity, I offer disorienting guitar practice as a critical lens which can materialize efforts at refusing the linearity of guitar technique as well as guitar hero worship. Consideration is given to St. Vincent's pairing of a disorienting virtuosity with her extension of the guitar's sonic possibilities through effect pedals.
Surface activation of plasma clotting: a function of Hageman factor.

Summary1. Asbestos treatment of plasma produced activation (clotting-time acceleration) in normal and AHF, PTC, proconvertin, prothrombin, proaccelerin and Stuart deficient plasmas. Hageman deficient plasma was not activated by comparable treatment. 2. Purified Hageman factor preparations from normal sera simulated activation, whereas preparations from sera of Hageman trait patients were inactive in the same test system. 3. The phenomenon of surface activation resulted from Hageman factor activation and was not due to inhibitor adsorption. 4. Asbestos treatment of plasma may be used as a presumptive test for Hageman trait.
Research and Design of Ethernet Interface at the Merging Unit

The interface of electronic instrument transformers and secondary equipment is realized by merging unit in the digital substation.The interface design of digital output is the key design on merging unit and the important items for inspection and testing.This paper analyses the digital output requirement according to electronic instrument transformers and IEC61850-9 standard and puts forward to a realization scheme of digital output frame.On this basis,the scheme of interface design based on DSP and FPGA is proposed and the realization method of hardware and software is detailed introduced.Experimental results show that this scheme can be well used in digital output of merging unit.
Domestic minor sex trafficking: beyond victims and villains

Lutnick’s book, Domestic Minor Sex Trafficking: Beyond Victims and Villains, provides a platform, beyond the predominant narrative of modern-day slavery, for discussion of commercial sex involving ...
Analysis of RPE morphometry in human eyes.

PURPOSE To describe the RPE morphometry of healthy human eyes regarding age and topographic location using modern computational methods with high accuracy and objectivity. We tested whether there were regional and age-related differences in RPE cell area and shape. METHODS Human cadaver donor eyes of varying ages were dissected, and the RPE flatmounts were immunostained for F-actin with AF635-phalloidin, nuclei stained with propidium iodide, and imaged with confocal microscopy. Image analysis was performed using ImageJ (NIH) and CellProfiler software. Quantitative parameters, including cell density, cell area, polygonality of cells, number of neighboring cells, and measures of cell shape, were obtained from these analyses to characterize individual and groups of RPE cells. Measurements were taken from selected areas spanning the length of the temporal retina through the macula and the mid-periphery to the far periphery. RESULTS Nineteen eyes from 14 Caucasian donors of varying ages ranging from 29 to 80 years were used. Along a horizontal nasal to temporal meridian, there were differences in several cell shape and size characteristics. Generally, the cell area and shape was relatively constant and regular except in the far periphery. In the outer third of the retina, the cell area and shape differed from the inner two-thirds statistically significantly. In the macula and the far periphery, an overall decreasing trend in RPE cell density, percent hexagonal cells, and form factor was observed with increasing age. We also found a trend toward increasing cell area and eccentricity with age in the macula and the far periphery. When individuals were divided into two age groups, <60 years and ≥60 years, there was a higher cell density, lower cell area, lower eccentricity, and higher form factor in the younger group in the macula and the far periphery (p<0.05 for all measurements). No statistically significant differences in RPE morphometry between age groups were found in the mid-periphery. CONCLUSIONS Human cadaver RPE cells differ mainly in area and shape in the outer one third compared to the inner two-thirds of the temporal retina. RPE cells become less dense and larger, lose their typical hexagonal shape, and become more oval with increasing age.
Phenylephrine infusion for spinal-induced hypotension in elective cesarean delivery: Does preload make a difference?

Background and Aims: Patients undergoing elective cesarean delivery (CD) have a high-risk of spinal-induced hypotension (SIH). We hypothesized that a colloid preload would further reduce SIH when compared with a crystalloid preload. Material and Methods: Eighty-two healthy parturients undergoing elective CD were included in the study. Patients were randomly assigned to two groups (41 patients in each group) to receive either Lactated Ringer's solution (1500 ml) or hydroxyethyl starch (6% in normal saline, 500 ml) 30 min prior to placement of spinal anesthesia. All patients were treated with a phenylephrine infusion (100 mcg/min), titrated during the study. Results: There was no statistical difference between groups with regards to the incidence of hypotension (10.8% in the colloid group vs. 27.0% in the crystalloid group, P = 0.12). There was also no difference between groups with respect to bradycardia, APGAR scores, and nausea and vomiting. Significantly less phenylephrine (1077.5 ± 514 mcg) was used in the colloid group than the crystalloid group (1477 ± 591 mcg, P = 0.003). Conclusion: The preload with 6% of hydroxyethyl starch before CD might be beneficial for the prevention of SIH.
Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice.

Background Morbid obesity increases the cost of care in critically ill patients. Sepsis is the leading cause of death in noncoronary intensive care units. Circulating cell-endothelial cell interactions in microcirculation are the rate-determining factors in any inflammation; obesity increases these interactions further. Adiponectin deficiency is implicated in increased cardiovascular risk in obese patients. We have shown that adiponectin deficiency increases microvascular dysfunction in early sepsis. In the present study, we investigated the effect of adiponectin replacement on nutritionally obese mice with early sepsis. Methods We used cecal ligation and puncture model of sepsis in mice with diet-induced obesity (DIO) vs control diet (CTRL), with or without adiponectin treatment. We studied leukocyte/platelet adhesion in the cerebral microcirculation in early sepsis. We also studied the effect of adiponectin on free fatty acid (FFA)-fed and lipopolysaccharide-stimulated bone marrow-derived macrophages (BMDM) for mechanistic studies. Results Leukocyte and platelet adhesion increased in the cerebral microcirculation of DIO and CTRL mice with early sepsis vs. sham; moreover cell adhesion in DIO-sepsis group was significantly higher than in the CTRL-sepsis group. Adiponectin replacement decreased leukocyte/platelet adhesion in CTRL and DIO mice. In FFA-fed BMDM, adiponectin treatment decreased tumor necrosis factor-alpha mRNA expression and increased sirtuin-1 (SIRT1) mRNA expression. Furthermore, using BMDM from SIRT1 knockout mice, we showed that the adiponectin treatment decreased inflammatory response in FFA-fed BMDM via SIRT1-dependent and -independent pathways. Conclusion Adiponectin replacement attenuates microvascular inflammation in DIO-sepsis mice. Mechanistically, adiponectin treatment in FFA-fed mouse macrophages attenuates inflammatory response via SIRT1-dependent and -independent pathways.
Skin Conductance as an In Situ Marker for Emotional Arousal in Children with Neurodevelopmental Communication Impairments: Methodological Considerations and Clinical Implications

Even though electrodermal activity has been widely used in the study of psychological states and processes for over 130 years, the use of such technology in situ, within the context of daily activities, remains a major challenge. Recent technological advancements have led to the development of wearable biosensors that noninvasively measure electrical conductance across the skin. These biosensors represent a new approach for skin conductance assessment, as a proxy for emotional arousal, in children with neurodevelopmental communication impairments who are often described as having difficulties with emotional regulation, expressing thoughts and feelings, and present a higher prevalence of challenging behaviors. Here we provide an overview of skin conductance and explore the benefits of recent technological advancements for applied research and clinical practice. We draw on user experience from two experimental interventions involving eight children with neurodevelopmental impairments. In both cases investigators monitored phasic and tonic EDA measures in situ using wearable biosensors. We share the behavioral and technical challenges experienced across these two experimental contexts, and propose associated considerations for future use. Specifically, sensor functioning, synchronization, and data preprocessing/analysis difficulties, as well as behavioral findings related to developmental differences, sensor tolerance over time, and sensor placement are discussed.
Economic inequality increases risk taking

Rising income inequality is a global trend. Increased income inequality has been associated with higher rates of crime, greater consumer debt, and poorer health outcomes. The mechanisms linking inequality to poor outcomes among individuals are poorly understood. This research tested a behavioral account linking inequality to individual decision making. In three experiments (n = 811), we found that higher inequality in the outcomes of an economic game led participants to take greater risks to try to achieve higher outcomes. This effect of unequal distributions on risk taking was driven by upward social comparisons. Next, we estimated economic risk taking in daily life using large-scale data from internet searches. Risk taking was higher in states with greater income inequality, an effect driven by inequality at the upper end of the income distribution. Results suggest that inequality may promote poor outcomes, in part, by increasing risky behavior.
The Impact of Social Exclusion on "Reading the Mind in the Eyes" Performance in Relation to Borderline Personality Disorder Features.

In this study we used the Reading the Mind in the Eyes Test (RMET) to explore facial emotion recognition in borderline personality disorder (BPD). We also used Cyberball, a computerized task designed to mimic social ostracism, to examine the response of BPD-feature participants to social exclusion. Seventeen individuals with BPD features were compared to 16 healthy controls on RMET performance pre- and post-exclusion via Cyber-ball. Our results revealed a significant interaction between BPD-feature status and RMET performance in relation to neutral stimuli following a social exclusion experience. BPD participants’ ability to correctly identify neutral faces significantly decreased following exclusion. This finding suggests that once an individual with BPD features experiences a social exclusion event, his or her objectivity decreases and affective valence is ascribed to stimuli previously perceived as neutral. Our results may help to explain, in part, the social instability seen in BPD.
First Clinical Report on Comparative Treatment and Survival Outcomes in Second Cancers after Primary Head and Neck Cancer: A Population-Based Study.

INTRODUCTION To compare patients' survival of second primary malignancy (SPM) after head and neck squamous cell carcinoma (HNSCC). METHODS The Surveillance, Epidemiology, and End Results (SEER) database was utilized (1973-2011). The Kaplan-Meier method with log-rank test was used to compare the overall survival (OS) and cause-specific survival (CSS) among treatment methods from the time of diagnosis of SPMs. Cox proportional regression models were used to adjust the impact for risk factors on CSS. RESULTS A total of 3,038 patients were identified (5-yr OS 22.6% (21.0-24.3%)). For head and neck (HN) SPMs, the patients who received 'conservative surgery with radiation' had the best 5-yr OS (65.2% (48.9-86.9%)); and the 'conservative surgery' group had the best 5-yr CSS (89.9% (85.6-94.5%)). For lung SPMs, the 'radical surgery' group showed the best survival (2-yr OS 60.8% (56.0-66.1%), 2-yr CSS 70.6% (65.8-75.8%), respectively). Esophagus SPMs had poor prognosis, with no difference among the treatment groups. In lung SPMs, younger age (p<0.001) and black race (p<0.05) were most favorable CSS predictors. CONCLUSIONS The prognosis of SPMs after HNSCC is worse compared with corresponding primary tumor. Conservative surgery with or without radiation showed the most favorable outcomes in HN SPMs.​.
Towards seamlessly-integrated textile electronics: methods to coat fabrics and fibers with conducting polymers for electronic applications

Traditional textile materials can be transformed into functional electronic components upon being dyed or coated with films of intrinsically conducting polymers, such as poly(aniline), poly(pyrrole) and poly(3,4-ethylenedioxythiophene). A variety of textile electronic devices are built from the conductive fibers and fabrics thus obtained, including: physiochemical sensors, thermoelectric fibers/fabrics, heated garments, artificial muscles and textile supercapacitors. In all these cases, electrical performance and device ruggedness is determined by the morphology of the conducting polymer active layer on the fiber or fabric substrate. Tremendous variation in active layer morphology can be observed with different coating or dyeing conditions. Here, we summarize various methods used to create fiber- and fabric-based devices and highlight the influence of the coating method on active layer morphology and device stability.
Neural Network Models of Human Executive Function and Decision Making

Neural network modeling, first developed in the mid-12th century, has reached a point where it has yielded sophisticated quantitative models of executive functions. This chapter reviews computational models of executive processes including decision making, sequence learning, suppressing habitual responses, and cognitive control.
A directional coherence attribute for seismic interpretation

The coherence attribute is one of the most commonly used attributes in seismic interpretation. In this paper, we propose building on the recently introduced Generalized Tensor-based Coherence (GTC) attribute to make it directionally selective. This directional selectivity is achieved by selecting a directional Gaussian preprocessing kernel and applying a 3D rotational matrix to its covariance matrix. By weighing traces, or voxels, in the analysis cube by their relative proximity to the reference trace or voxel, this approach greatly enhances the clarity of the attribute. Furthermore, by making these weights directional, the proposed attribute gives interpreters greater freedom in exploring and understanding the seismic data. Various results from the Netherlands North Sea F3 block show that this approach greatly enhances the clarity of the coherence attribute and can highlight structures that are not visible using the traditional C3, or GTC coherence.
OPTIMAL POSITIONING OF MEDTRONIC CORE VALVE BEFORE DEPLOYMENT DECREASES PARAVALVULAR REGURGITATION POST TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR)

The Medtronic Core Valve (MCV) can be recaptured and repositioned, allowing the TAVR operator to minimize paravalvular leak (PVL). We evaluated the association between PVL and angiographic measurements of MCV position during deployment stages while the MCV is recapturable. 470 patients with TAVR (