cssi/SciSciGPT-SciSciNet huggingface dataset:
Quotient representations of meromorphic functions

Let f be a meromorphic function in [z I 0. It is implicit in the method of proof that for any B > 1 there is a corresponding A for which the desired representation holds for all f . We show that in general B cannot be chosen to be 1 by giving an example of a meromorphicfsuch that if f = fl]f2 where f l and f2 are entire then T(r,f2) # O(T(r,f)). Rubel and Taylor have obtained the above theorem for special classes of meromorphic functions. In particular it is shown in I-5] that such a representation exists for any meromorphic f such that either sup T(2r,f)]T(r,f) _l or such that log T(r,f) is a convex function of log r. Although the representation is not obtained in [-5] for all meromorphic functions, the general result is shown to be equivalent to a seemingly more elementary proposition concerning sequences of complex numbers. The contribution of this paper is to prove the result concerning sequences of complex numbers and to provide an example showing the theorem is sharp. Results in this direction for functions of several complex variables appear
Coupled diffusion of temperature and moisture

The interdependence of heat and moisture in solids has been discussed in [1–3]. It was demonstrated [3] that the effective diffusion constants measured in typical experiments [4] are equal to the diffusion coefficients of the material only in the case of very weak coupling. The processes of heat and moisture transfer can be coupled depending on the specified environmental conditions. An initially uniform dry solid can be suddenly immersed in a body of water of the same temperature which is kept constant. The solid will absorb moisture at a rate which is initially proportional to the square root of time [2, 3, 5]. The slope of the moisture content versus square root of time curve can then be used to compute the effective diffusion coefficient. It depends [3] on the diffusion coefficients for both heat and moisture and on the coupling parameters associated with the heat and moisture flow rate. In addition to this reinterpretation of experimental results of classical tests, there is the related diffusion of heat in the same test. For conditions in which moisture diffuses into the solid, heat has also diffused into the solid at a rate porportional to the square root of time initially resulting in an increase in temperature of the solid [2]. Ultimately, as the diffusion of moisture slows down, the flow of heat is reversed and the temperature of the solid decreases to its initial value. These are similar reciprocal effects for the case in which a slab is suddenly subjected to a change in surface temperature with no change in the surface moisture concentration [2, 3]. Experimental results on coupling of heat and moisture in textile materials can be found in [5].
The cell biology of the COP/DET/FUS proteins. Regulating proteolysis in photomorphogenesis and beyond?

Plants as sessile organisms have evolved a great deal of developmental plasticity to optimally respond to their immediate environment. Because light is one of the most important cues for plant growth, mechanisms to respond to light conditions are highly elaborated. In particular, the transition from
Trench isolation technology

The process technologies associated with fabricating trench isolation are discussed along with current process and device concerns. Potential development directions required for further refinements and diversification to satisfy future device designs are also considered. The following process elements are examined: trench formation, trench linear formation, trench filling, and surface replanarization. >
Describing service in independent demand inventory systems

We discuss the notion of service in independent demand inventory systems with random demand, and note several areas where existing pedagogy can be improved. We survey a collection of 23 operations management textbooks and recommend that different treatments be made. Specifically we recommend that the concept of Cycle Service, sometimes referred to as Type I Service should be abandoned as it is typically treated in operations management textbooks. We also recommend making a fundamental change in the way that periodic review systems are depicted. The recommendations are made on the basis of general concepts of the notion of customer service and on the basis of long-standing theoretical results from the field of mathematical inventory theory.
Motorized facilitated ankle stretching

Proprioceptive neuromuscular facilitation (PNF) technique combines both passive and active stretching and significant improvement on muscle strength and coordination has been reported. Therefore PNF technique will be an excellent candidate as a more effective intervention strategy in stroke rehabilitation. The goal of this study is to develop a motorized device which could successively implement PNF hold-relax technique on the ankle joint. The motorized device consists of a servo motor, an inline gear box with a 25:1 gear ratio which increases the loading capacity of the motor up to 50 Nm, one uniaxial torque sensor to register the torque signal. The motor is controlled by a motor drive using speed mode in which both speed and direction of the motor rotation could be modulated. National Instrument PCI6221 M Series data acquisition card was used for data acquisition and motor control. A custom graphical user interface (GUI) written in LabVIEW is used to set testing parameters including speed, ankle range of motion and display testing results in real time. Preliminary study showed that PNF technique can be successfully implemented using the developed motorized ankle device interfaced with the GUI. It is expected that the motorized facilitated ankle intervention will be more effective in increasing ankle joint range of motion and neuromuscular function. It will be a promising intervention for treating spastic joint in stroke survivors.
Gigascale integration: is the sky the limit?

Early 21st century opportunities for Gigascale integration (GSI) will be governed by a hierarchy of theoretical and practical limits whose five levels can be labeled as: 1) fundamental, 2) material, 3) device, 4) circuit, and 5) system. This article reviews recent enhancements of this hierarchy and identifies those critical limits that appear to present the most formidable challenges to continued progress toward GSI.
Variations in Alkali Reserve of Plasma and Excretion of Total Titratable Urinary Acid in Hyperthyroidism

SummarySerial observations on 18 patients reveal a rise of carbon dioxide-combining power of the plasma in 8 cases as their clinical status improves with treatment and operation. All values fall within the normal range. The excretion of total titratable acid of the urine in 9 patients on constant diets is reported. In the patients in whom decided improvement occurs shortly after operation, the preoperative amounts are from 2 to 4 times as large as those excreted postoperatively. Excretion of organic acids and ammonia nitrogen were also followed for nearly a month in one patient and in exacerbations of hyperthyroidism her excretion of these substances, as well as of total acid, is seen to rise; urinary pH values fall during exacerbations. In 2 patients who improved promptly following thyroidec-tomy, fall in total acid excretion is accompanied by a rise of alkali reserve; in a third patient who showed little early improvement and only a slight change of total acid excretion, there was no change in carbon di...
When Receiving Help Hurts: Gender Differences in Diurnal Cortisol Responses to Spousal Support

Wives are considered more effective support providers than are husbands. As support promotes healthy physiological functioning, husbands should derive greater health benefits from spousal support than do wives. Yet, a growing literature indicates that men are relatively insulated from the physiological consequences of marital interactions, suggesting that men may not reap the benefits that support can provide. To examine gender differences in physiological responses to spousal support, couples completed a 6-day diary task that assessed daily support exchanges and diurnal cortisol slopes. On days of greater spousal support, wives exhibited steeper cortisol slopes, whereas husbands exhibited flattened cortisol slopes. Furthermore, for husbands, the association between daily support and cortisol was moderated by problem-solving efficacy; the less efficacious husbands perceived their problem-solving abilities, the flatter their cortisol slopes on high support days. All results held controlling for daily stres...
Thermal Conductivity of Quartz Sands by Thermo-Time Domain Reflectometry Probe and Model Prediction

AbstractThe heat transfer process in soil depends on its thermal conductivity property and is affected by soil compositional and environmental factors, such as soil gradation, mineralogy components, compaction moisture content, and dry unit weight conditions. In this research, thermal conductivities of three quartz sands were studied using a newly developed thermo–time domain reflectometry (TDR) probe. The test results revealed that thermal conductivity of quartz sands increased with compaction moisture content and dry unit weight. Higher quartz content also led to higher thermal conductivity. The new thermo-TDR probe provided measurements of thermal properties similar to those of the standard KD2 probe. The deviation of the two methods was within 5%. An improved thermal conductivity model was also proposed on the basis of the normalized thermal conductivity concept and present experimental data. This improved model exhibited the highest accuracy in thermal conductivity predictions of quartz sands (within...
Transforming growth factor-{beta}: a biomarker in Marfan syndrome?

Marfan syndrome is an autosomal dominant disorder of connective tissue due to abnormal fibrillin-1 caused by mutations in the FBN1 gene on chromosome 15. Affecting 1 in ≈5000 individuals, Marfan syndrome has widespread features involving the cardiovascular system, eye, skeleton, lung, dura, and skin. After evaluation of individuals and families with Marfan syndrome over the years, it is remarkable how variable the phenotype and age of onset of various manifestations may be among affected individuals, even in the same family. Some individuals with Marfan syndrome require aortic root replacement early in childhood, whereas others may not require aortic surgery until late in life, if at all. This highlights the importance of thorough screening of all first-degree relatives of the Marfan patient, long-term follow-up, and consideration of mutation analysis for those with ambiguous features. Article see p 526 The past 2 decades have witnessed remarkable scientific discovery and progress, providing hope to those affected by Marfan syndrome. In 1991, it was discovered that Marfan syndrome was due to a mutation in FBN1 , the gene that encodes fibrillin-1.1 Hundreds of different mutations in FBN1 have subsequently been described, with most families having their own private mutation. Because fibrillin-1 is present in tissues affected by Marfan syndrome, it was considered that the underlying defect in fibrillin-1 led to a primary structural weakness in this connective tissue protein. Because of recent discovery, this concept has come into question. Genetically engineered mouse models of Marfan syndrome, which recapitulate the phenotype observed in humans, have revolutionized understanding of basic pathophysiological mechanisms of this disease.2–4 Fibrillin-1 is a 350-kDa glycoprotein with multiple repeating, cysteine-rich, epidermal growth factor–like motifs, most of which are calcium binding. Fibrillin-1 also has motifs with homology to latent transforming growth factor-β–binding proteins. Fibrillin-1 proteins aggregate and associate to form microfibrils, …
Participation Patterns in Campus Recreational Sports: An Examination of Quality of Student Effort from 1983 to 1998

The 1980s and 1990s saw tremendous growth in campus recreational sports programs. The emergence of these programs as significant contributors to the higher education mission has led practitioners t...
Combining Transarterial Chemoembolization With Radiofrequency Ablation for Hepatocellular Carcinoma: One Step Forward?

Managementofhepatocellularcarcinoma(HCC),thesixthmost common cancer and the third most common cause of cancer-related death globally, 1 continues to present many challenges. First, despite the
Hand injury patterns in softball players using a 16 inch ball

Softball is a popular recreational and competitive sport among both men and women. The injury rate in softball players is as high as that in baseball and basketball players. We conducted a retrospective analysis of 119 hand injuries in 108 patients treated at the University of Chicago hand clinic. All of the injuries were caused by the impact of a 16 inch circumference softball. Of the 119 injuries, 87 (73%) had bone involvement. Operative treatment was required in 26 (22%) injuries, 23 involving fractures and 3 involving soft tissue only. There was one (3.8%) operative complication. Of all injuries, 101 (86%) involved the finger joints, including 46 (39%) injuries to the distal interphalangeal (DIP) joint, 48 (40%) to the proximal interphalangeal (PIP) joint, and 7 (6%) to the metacarpophalangeal (MCP) joint. The most common DIP joint injury was a mallet injury. This fracture, the most common single type of injury in our series, accounted for 27% of all injuries. Of all mallet injuries, 86% were fractures. The most common PIP joint injury was a volar plate fracture, the second most common injury in our series. Variables such as the patient's sex, dominance or nondominance of hands, and early or late season play were not associated with a higher risk of injury. Certain parts of the hand, such as the more ulnar digits and the DIP and PIP joints, were at particularly high risk of injury.
Miniaturized integrated folded helical antennas

This paper presents a folding scheme to address fundamental issues of planar electrically small resonant antennas with small radiation resistance, high Q factor, and narrow bandwidth. Two printed folded helical antennas are investigated as examples of small antennas for GSM1800/1900 bands. Dramatic bandwidth enhancements of as much as 66% and 163% are found, respectively, for folded helical dipole and its monopole version over their non-folded counterparts. The proposed folding method facilitates integrated antenna miniaturization with self resonance, sufficient bandwidth, and self impedance matching.
Biomarkers of HIV-1 Associated Dementia: Proteomic Investigation of Sera

New, more sensitive and specific biomarkers are needed to support other means of clinical diagnosis of neurodegenerative disorders. Proteomics technology is widely used in discovering new biomarkers. There are several difficulties with in-depth analysis of human plasma/serum, including that there is no one proteomic platform that can offer complete identification of differences in proteomic profiles. Another set of problems is associated with heterogeneity of human samples in addition intrinsic variability associated with every step of proteomic investigation. Validation is the very last step of proteomic investigation and it is very often difficult to validate potential biomarker with desired sensitivity and specificity. Even though it may be possible to validate a differentially expressed protein, it may not necessarily prove to be a valid diagnostic biomarker. In the current study we report results of proteomic analysis of sera from HIV-infected individuals with or without cognitive impairment. Application of SELDI-TOF analysis followed by weak cation exchange chromatography and 1-dimensional electrophoresis led to discovery of gelsolin and prealbumin as differentially expressed proteins which were not detected in this cohort of samples when previously investigated by 2-dimensional electrophoresis with Difference Gel Electrophoresis technology. Validation using western-blot analysis led us to conclude that relative change of the levels of these proteins in one patient during a timeframe might be more informative, sensitive and specific than application of average level estimated based on an even larger cohort of patients.
Pediatric Teledermatology Consultations: Relationship Between Provided Data and Diagnosis

There is a shortage of pediatric dermatologists. Teledermatology has emerged as a tool to facilitate access to dermatologists. Many questions remain regarding how to optimize consultations in order to provide the best diagnosis and management recommendations. The aim of this retrospective cohort study was to categorize the historical data and judge the adequacy of photographs sent by referring providers to our academic pediatric teledermatology practice at the University of California, San Francisco, and to evaluate the relationship of these data to our ability to render a diagnosis. A diagnosis was rendered in 75% of cases. The only historical data associated with receiving a diagnosis was prior treatment (OR 2.01, CI 1.01, 4, p < 0.05). Appropriate image distance from the target was associated with receiving a diagnosis for rashes (OR 2.69, CI 1.07, 6.8, p = 0.04) and growths (OR 4.16, CI 1.04, 16.6, p = 0.04). A lack of diagnosis was significantly associated with a recommendation for referral for biopsy (OR 0.03, CI 0.01, 0.10, p < 0.0001) or for in-person consultation (OR 0.19, CI 0.05, 0.66, p < 0.001). In conclusion, pediatric teledermatologists are able to make a diagnosis most of the time, regardless of historical information provided or image quality. The rate of diagnosis may be improved with the use of standardized templates for historical information. Similarly, photography training could minimize the need for in-person consultation. Specific information regarding prior treatments could also help in providing useful management recommendations.
Family Structure History and Adolescent Romance

This study examined the association between family structure history and adolescent romance. Using a national sample drawn from Add Health (N= 13,570), family structure at Wave I was associated with the likelihood that adolescents were involved in a romantic relationship at Wave II and, among those in a relationship, the number of relationships they had since Wave I. Cumulative family instability and its timing were also associated with these outcomes and largely drove the family structure effects. Gender and age interactions suggest that experiences of family instability were more consequential to the romantic lives of boys and younger teens.
What Is Special About Special Education for Students with Emotional or Behavioral Disorders

Although students with emotional or behavioral disorders have historically experienced poor school outcomes compared to other students with and without disabilities, a number of effective practices are available that can make special education for students with emotional or behavioral disorders special. Within the three broad intervention areas of inappropriate behavior, academic learning problems, and interpersonal relationships, we provide a brief overview of a number of empirically validated practices. We argue that teaching students with emotional or behavioral disorders demands unique interventions that are beyond that typically available or necessary in general education. We conclude that special education is special for students with emotional or behavioral disorders and that it can be even more special with greater efforts at implementing research-based practices early, with integrity, and sustaining these interventions over the course of students’ school careers.
Endogenous hyperglycemia restores insulin release impaired by somatostatin analogue

These studies assessed the ability of des-Asn5-[D-Trp8-D-Ser13]-somatostatin (d-ATS-SS) to selectively inhibit insulin release and produce a hyperglycemia sufficient to compensate for the original impairment. d-ATS-SS at 0.017 micrograms/min inhibited basal insulin output (delta = -38 +/- 6%, P less than 0.005) and increased basal pancreatic glucagon output (delta - +21 +/- 6%, P less than 0.05, n = 5). d-ATS-SS at 0.17 micrograms/min markedly inhibited insulin output (delta = -84 +/- 4%, P less than 0.0005) and slightly inhibited glucagon output (delta = -14 +/- 6%, P less than 0.05, n = 5). d-ATS-SS at 0.055 micrograms/min decreased basal and stimulated insulin release but not basal nor stimulated glucagon release. By 3.5 of analogue infusion, plasma glucose had risen by 116 +/- 13 mg/dl, and base-line insulin levels and the insulin responses to both isoproterenol and arginine, but not glucose, increased toward control values. We conclude that d-ATS-SS produces selective insulinopenia resulting in hyperglycemia which in turn compensates for the original impairment. Thus, the hyperglycemia observed in other states of selective insulin deficiency (e.g., noninsulin-dependent diabetes mellitus) may compensate for defects in beta-cell function.
4.1× 10 − 8 Second Metastable State in Pa 231

A metastable state of ${\mathrm{Pa}}^{231}$ with a half-life of (4.1\ifmmode\pm\else\textpm\fi{}0.4)\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}8}$ second has been observed. This half-life is exhibited by both 26- and 85-kev $E1$ gamma transitions. A comparison is made with the metastable state in ${\mathrm{Pa}}^{233}$. Upper limits on lifetimes are given for the $E1$ gamma transitions in ${\mathrm{Np}}^{239}$ and ${\mathrm{Ac}}^{225}$. The erratic variation in the lifetimes for $E1$ transitions is discussed.
Multiple UAV Target Tracking Using Consensus-Based Distributed High Degree Cubature Information Filter

In this paper, a distributed nonlinear estimation scheme is proposed for target tracking with a team of UAVs. The maneuvering target is modeled as a jump Markov nonlinear system and the interacting multiple model approach is employed based on the integration of a new high degree cubature information filter with the consensus algorithm. Each UAV only communicates with its neighbors and the fusion of the estimates is achieved by the distributed information filtering and the consensus process. In addition to the advantages of the distributed tracking, the proposed scheme is able to achieve higher estimation accuracy than the unscented information filter.
Experiment study on the principle of solid fuel scramjet

Solid fuel scramjet was investigated by experiment.Ignition and combustion experiments that include solid hydrocarbon fuel and PMMA fuel were successfully done,which proved reliable ignition of the solid fuel in supersonic flow and stable combustion of the flame.Finally supersonic chamber characteristics of solid fuel were obtained.Combustion of PMMA fuel in supersonic flow was also investigated,and its regression rule was analyzed.Results show that regression rate of PMMA fuel changes with time,combustion outline tends to be plane and combustion region exhibits column.
Sibling separation and health risk behaviors of children orphaned by acquired immune deficiency syndrome

Objective:To explore the relationship between sibling separation and health risk behaviors in children orphaned by acquired immune deficiency syndrome(AIDS).Methods:Totally 155 children aged 6-17 years who lost both of their parents to AIDS and with at least one sibling were selected.Among them,96 double orphans were separated from their siblings and 59 double orphans were not separated from their siblings;97 double orphans were placed in orphanage,8 double orphans were placed in group home and 50 double orphans were placed in kinship care at the time of this study.They were assessed with the Health Risk Behaviors Scale.Results:The children separated from their siblings got higher scores in "alcohol use" [(1.6±0.7) vs.(1.4±0.5)],"beating up someone" [(1.5±0.8) vs.(1.3±0.6)] and "public property destruction" [(1.1±0.5) vs.(1.0±0.0)] than those who did not experienced sibling separation(Ps0.05).The children living in the orphanage got significantly higher scores than the children living in the group home and adopted by relatives on "beating up someone" [(1.6±0.8) vs.(1.2±0.4),(1.2±0.4);Ps0.05].Multivariate analysis showed that after controlling for age,care arrangement,number of household replacement,trusting relationship with the current caregivers and perceived quality of current living condition,sibling separation was associated with higher scores in "alcohol use" and "threatening to hurt someone" [(1.2±0.5) vs.(1.1 ± 0.2),P0.05].Conclusion:It suggests that children orphaned by AIDS separated from their siblings may suffer from more health risk behaviors than those who have symbiosis with their siblings.
Survey of foodborne disease outbreak caused by Salmonella stanley

To identify the pathogen causing 3 clusters of diarrhea cases and 1 suspected food poisoning event.Biological samples of the cases and related person,food and environmental samples were collected for the isolation of pathogen. Among the 19 samples collected,10 were Salmonella stanley positive( 4 from food samples,5 from cases' stool samples and 1 from anal swab of one related person) and all the S. stanley strains shared same PFGE pattern. It was confirmed that the foodborne disease outbreak was caused by S. stanley.
Some Aspects on the History of Computational Quantum Chemistry in view of the Development of the Supercomputers and Large-Scale Parallel Computers

When Max Planck1 introduced the quantum postulate E = hv in 1900, the main purpose was to give a theoretical description of the black-body radiation in agreement with the experimental experience. When Albert Einstein2 in 1905 introduced the quantization of the electromagnetic waves according to the law E = hv, the idea was to give a theoretical explanation of the photo-electric effect. When Niels Bohr3 in 1913 developed the first model of the hydrogen atom based on the quantization of angular momenta, pa = nh/2π, the success was guaranteed by the fact that his theoretical results were in agreement with the experimental spectra. Somewhat later Sommerfeld4 introduced the three quantum numbers (n, l, m) describing the elliptical orbits, and in 1918 he could successfully explain the fine-structure of the hydrogen atom spectra by using the special theory of relativity and the fine-structure constant α = 2πe2/hc = 1/137.
Beginning careers in academic psychiatry for women--"Bermuda Triangle"?

OBJECTIVE The proportion of women in leadership positions in academic psychiatry has not kept pace with the increase in the number of women entering the field. This study examines differences in career activities between women and men who graduated from the Yale University psychiatric residency training program and explores whether these differences can be explained by preresidency expectations, residency experiences, or training immediately after residency. METHOD Departmental educational records of the Yale residency program were reviewed to determine professional interests expressed before psychiatric residency and training focus during residency for 355 residents in the 1970-1983 graduating classes. A 1984 follow-up study focused on their postresidency career activities. Differences in preresidency interests and experiences, training activities, and career paths between all female and male graduates and between women and men who chose academic careers were examined. RESULTS After residency, the female graduates' marital status differed from men's--more had never married or were divorced. Women's professional activities diverged from men's; their practice pattern was different, they spent more hours teaching, and they had fewer publications in peer-reviewed journals. This divergence was not accounted for by differences in pretraining interests or in training focus during residency. The authors present possible explanations. CONCLUSIONS Further research is indicated to determine the underlying causes of career differences between women and men in psychiatric practice and academia so that effective strategies for correcting the present inequality of women in senior faculty positions can be implemented.
Colloidal Nanoclusters of MgO Coated with Alkali Metal Nitrates/Nitrites for Rapid, High Capacity CO2 Capture at Moderate Temperature

Colloidal nanoclusters of metal oxides constitute a promising new class of building blocks for a range of advanced functional materials. Herein, we report on the development of colloidal nanoclusters of MgO for CO2 capture prepared by a novel nonhydrolytic sol–gel reaction followed by the deposition of alkali metal salts by methanol evaporation-induced surface precipitation. The CO2 uptake exceeded 11.7 mmol g–1 (514.8 mg CO2 per 1 g of adsorbent) in 30 min in the presence of 100% dry CO2 under ambient pressure (1 bar) at 340 °C and reached 15.7 mmol g–1 (690.8 mg CO2 per 1 g of adsorbent) in 4 h. Colloidal nanoclusters possessing multiple inner grain boundaries and rough surfaces allowed for a dramatic increase in active surface area of MgO coated with thin layers of alkali metal salts and enabled the rapid conversion of MgO to MgCO3 with high conversion ratio. It was also discovered that the CO2 uptake loading and the regenerability of the sorbents can be enhanced on introduction of nitrite salts to the...
Unmanned Aerial Vehicle (UAV)-Assisted Water Sampling

Abstract. Water quality assessment programs require the collection of water samples for physical, chemical and bacteriological analysis. Lack of personnel, accessibility of water bodies and time of water sampling after natural disasters and emergencies are some of the challenges of water sampling. A water collection mechanism was developed and mounted on a multirotor unmanned aerial vehicle (UAV) for autonomous water sampling from water bodies. The payload capacity and endurance of the hexacopter were verified using an indoor test station. The hexacopter was equipped with floating foam, and the electronic components were coated against water damage in case of a crash, landing on water due to emergencies or for water sampling. The system was able to collect 130 ml of water for 48 times out of 73 flight missions from a pond. The unsuccessful missions were due to the malfunctions of the triggering mechanism of the water sampler. The UAV-assisted autonomous water sampling is a promising method for collection of water from water bodies. The system would be useful for collection of water samples from large lakes or difficult to access water sources. The details of the developed water sampling mechanism and the results of the experiments are reported in this paper.
Advanced imaging of glenohumeral instability: the role of MRI and MDCT in providing what clinicians need to know

The inherently unstable anatomy of glenohumeral (GH) joint predisposes it to shoulder dislocation. Shoulder dislocation can occur either due to acute trauma or due to chronic microtraumas in the setting of underlying morphological abnormality. A plain radiograph is the initial imaging modality for diagnosis and management of shoulder dislocation and its associated osseous abnormalities such as Hill-Sachs deformity or osseous Bankart lesion. However, advanced imaging techniques such as multidetector CT (MDCT) with three-dimensional (3D) volume rendering and MRI can be helpful in further characterization of osseous abnormalities and detection of associated soft tissue injuries, respectively. These additional findings may be useful for optimal surgical repair for GH joint stabilization. In this pictorial essay, we present the clinically relevant osseous and soft tissue pathologies in various types of shoulder dislocation, with emphasis on pathologies that can be demonstrated using advanced imaging examinations. Discussed pathologies include glenoid fractures, labral tears, Bankart lesion, Hill-Sachs defect, Perthes lesion, anterior labral posterior sleeve avulsion (ALPSA), glenolabral articular disruption (GLAD), humeral avulsion of the glenohumeral ligament (HAGL), Kim lesion, and other associated soft tissue and nerve injuries.
Genome Sequencing in a Case of Niemann-Pick Type C

Adult-onset Niemann-Pick disease type C (NPC) is an infrequent presentation of a rare neurovisceral lysosomal lipid storage disorder caused by autosomal recessive mutations in NPC1 (∼95%) or NPC2 (∼5%). Our patient was diagnosed at age 33 when he presented with a 10-yr history of difficulties in judgment, concentration, speech, and coordination. A history of transient neonatal jaundice and splenomegaly with bone marrow biopsy suggesting a lipid storage disorder pointed to NPC; biochemical ("variant" level cholesterol esterification) and ultrastructural studies in adulthood confirmed the diagnosis. Genetic testing revealed two different missense mutations in the NPC1 gene-V950M and N1156S. Symptoms progressed over >20 yr to severe ataxia and spasticity, dementia, and dysphagia with aspiration leading to death. Brain autopsy revealed mild atrophy of the cerebrum and cerebellum. Microscopic examination showed diffuse gray matter deposition of balloon neurons, mild white matter loss, extensive cerebellar Purkinje cell loss with numerous "empty baskets," and neurofibrillary tangles predominantly in the hippocampal formation and transentorhinal cortex. We performed whole-genome sequencing to examine whether the patient harbored variants outside of the NPC1 locus that could have contributed to his late-onset phenotype. We focused analysis on genetic modifiers in pathways related to lipid metabolism, longevity, and neurodegenerative disease. We identified no rare coding variants in any of the pathways examined nor was the patient enriched for genome-wide association study (GWAS) single-nucleotide polymorphisms (SNPs) associated with longevity or altered lipid metabolism. In light of these findings, this case provides support for the V950M variant being sufficient for adult-onset NPC disease.
pQC: A novel approach for robust automatic near-surface analysis in low-relief geology

A novel approach, named pQC, was developed to automatically derive near-surface velocities and statics by applying surface-consistent analysis to refraction data, where the data consist of first-break (FB) traveltimes and early-arrival waveforms. This approach is facilitated by the introduction of a new sorting domain in which FB traveltimes and traces are organized in a multidimensional space consisting of a common-midpoint (CMP) location, offset, and azimuth, called the XYOA domain. The FB traveltime data sorted in this domain can be analyzed efficiently with statistical methods to obtain localized average depth domain velocity trends for calculation of long-wavelength statics. Short-wavelength (residual) refraction statics are then calculated based on the cross correlation of early-arrival waveforms in the XYOA gathers over multiple offset classes and inverted for surface-consistent source and receiver corrections. The application of the combined statics solution to the traces enhances the continuity a...
P2F2: Privacy-preserving face finder

Fueled by the explosive growth in the number of pictures taken using smart phones, people are increasingly using cloud photo storage services. Although many innovative apps have been developed to leverage this collection of photos in the cloud, users are concerned with the privacy of their photos. We have developed Privacy-Preserving Face Finder (P2F2), a system that allows cloud-based photo matching, while preserving the privacy of the photos from the cloud provider. P2F2 stores encrypted photos in the cloud and performs photo matching based on feature vectors extracted from the photos. At its core, P2F2 relies on a novel privacy-preserving protocol for computing the Chi-square distance between the feature vectors of two photos. To achieve its goal, P2F2 extracts two privacy-preserving components from a photo's feature vector and stores them at non-colluding cloud providers. Unlike previous privacy-preserving work, P2F2 is designed to work with feature descriptors that are optimized for face recognition. An authorized querier can match a target face photo with a set of encrypted face photos stored in the cloud and receive the k most similar encrypted photos, which can then be decrypted. We have implemented a prototype of P2F2 and evaluated its performance using smart phones and a small-size cloud. Our security analysis and experimental evaluation show that P2F2 successfully achieves the desired security guarantees and is feasible in practical conditions.
“Even my sister says I'm acting like a crazy to get a check”: Race, gender, and moral boundary-work in women's claims of disabling chronic pain

Recent research examines how women claim chronic pain in response to gendered moral discourses. However, extant research does not explore how race shapes the moral boundary-work performed by women suffering from disabling chronic pain. Through the qualitative analysis of twenty-four semi-structured interviews with women fibromyalgia sufferers conducted between October 2014 and August 2016 in the U.S.A., I demonstrate how women with fibromyalgia claim chronic pain by doing moral boundary-work, referencing gendered and racialized moral discourses that structure how claims of chronic pain as disability are and are not read as legitimate by doctors, disability bureaucrats and personal networks. Extending Hansen et al.'s work on stigma and the "pathologization of poverty," I suggest that, per my sample, the different moral discourses deployed in white and Black women's claims of chronic pain can be explained by the racialized and gendered boundaries of citizenship that structure U.S. welfare and disability politics. Finally, I argue for intersectionality's relevance to research on moral boundary-work and the medicalization of poverty.
Probing single-molecule electron–hole transfer dynamics at a molecule–NiO semiconductor nanocrystalline interface

Interfacial charge transfer dynamics in dye-sensitized NiO nanoparticles are being investigated for photocathodes in p-type dye-sensitized solar cells. In the photoreaction, after fast electron transfer from NiO to a molecule, the recombination of the hole in the nanoparticles with the electron in a reduced molecule plays an important role in the charge separation process and solar energy harvesting. Nevertheless, knowledge of the interfacial charge recombination (CR) rate and its mechanism is still limited due to the complex photoinduced electron and hole dynamics and lack of characterization of the inhomogeneity of the dynamics. Here, we report our work on probing interfacial charge recombination dynamics in Zn(II)–5,10,15,20-tetra(3-carboxyphenyl)porphyrin (m-ZnTCPP) dye-sensitized NiO nanoparticles by correlating single-molecule fluorescence blinking dynamics with charge transfer dynamics using single-molecule photon-stamping spectroscopy. The correlated analyses of single-molecule fluorescence intensity, lifetime, and blinking reveal the intrinsic distribution and temporal fluctuation of interfacial charge transfer reactivity, which are closely related to site-specific molecular interactions and dynamics.
Endometrial cancer: Molecular markers and management of advanced stage disease

Abstract Endometrial cancer is the most prevalent gynecologic cancer in the United States. Over the last 10 years, death rates from endometrial cancer have been rising about 1.4% per year. Traditionally endometrial cancer treatment has been driven by stage and histology. Recent studies have, however, shown that cancers of the same stage and histology have very distinct molecular and genomic profiles. Translational research is progressing rapidly and endometrial cancer-specific precision medicine is evolving. The first tissue agnostic therapy based on the molecular profile of the tumor was approved by the FDA this year. The approval of immune checkpoint inhibitor, pembrolizumab (anti-PD-1), for all solid tumors with defective DNA mismatch repair, could benefit 20–30% of patients with advanced endometrial cancer. Other genomic changes and molecular markers in endometrial cancer, such as hormone receptor status, could lead to more tailored therapy in the future. Pre-clinical and clinical investigations of targeted therapies suggest efficacy for some agents. Single agent targeted therapies, however, have modest activity. Identifying biomarkers that effectively determine response to targeted therapy remains a challenge. The next generation of clinical trials will focus on novel combinations and how to best utilize the advances that have been made in sequencing technology and bioinformatics. Although there is currently an immense body of data and many options for obtaining genomic characteristics of endometrial cancer, how to interpret and utilize this data is still being explored. This review will summarize the important trials that have led to the treatment options we have for advanced and/or recurrent endometrial cancer and discuss the important studies that have led to a better understanding of the distinctive molecular and genomic profiles within endometrial cancer. We will review the current status of biomarker-driven targeted therapy in endometrial cancer and the rationale behind ongoing clinical trials that are utilizing novel targeted agents.
The gastrointestinal tract: Development, implementation & evaluation of a tailored continuing education "Best Practices" series for nuclear technologists

1028 Objectives: There is considerable variability in educational background and clinical experience of nuclear technologists in practice. Each department differs in imaging protocols, referral patterns, radiopharmaceutical availability and instrumentation. Therefore, traditional continuing education approaches at local/regional/national meetings may have limited direct applicability for individual technologists. At our institution, the nuclear radiologists developed, implemented, and evaluated the effectiveness of a tailored “Best Practices” program comprised of four structured modules on gastrointestinal scintigraphy. Methods: We developed 4 formal gastrointestinal modules for our technologists. The modules covered: (1) GI Bleeding/Meckel’s, (2) Hepatobiliary/Biliary Atresia, (3) Gastric Emptying/Aspiration and (4) Liver/Spleen/Liver Blood Pool. We administered the program as 4 one-hour sessions biweekly over 8 weeks; the clinical schedule was modified to facilitate attendance. Our 8 technologists completed a multiple-choice/short-answer test before the session (“pre-test”) and took the same test after the teaching session (“post-test”). 40% of the test questions were related to anatomy & physiology (“basic science”) and the remaining 60% to “clinical practice”. A comprehensive review test on all four topics is pending. Technologists’ individual and group performances were recorded and analyzed. Results: There was a statistically significant improvement in the performance in individual modules (p Conclusions: Traditional continuing education for nuclear technologists via formal lectures at local/regional/national meetings or individual feedback on a case-by-case basis cannot adequately address specific needs. We designed, implemented, and demonstrated the effectiveness of a new instructional program tailored by the nuclear radiologists for our own technologists. The technologists enthusiastically embraced the opportunity to learn and showed an overall average improvement of 22% after completing the four gastrointestinal tract modules. Enhanced morale and clinical performance suggest that this “Best Practices” series can serve as a model for other educational modules covering a variety of nuclear topics.
Supporters and Opponents of Federal Preemption Take Sides, Anticipate High Court's Ruling on Third FDA Preemption Case This Year

his fall term, on November 3, the Supreme Court is scheduled to hear oral argument in Wyeth v. Levine (No. 07562). The latest in a trilogy of FDA Preemption cases to make their way to the Court, Levine has been dubbed “the most highly anticipated pharmaceutical products liability ruling since the Court’s 1993 decision in Daubert v. Merrell Dow Pharmaceuticals.” “The outcome of this case will affect the fate of hundreds of state tort suits, consumer protection actions of state attorneys general, and the role of the states in our federal government,” says Massachusetts Attorney General Martha
JUST DO IT: Notes on Politics and Race at the Dawn of the Obama Presidency

President-elect Barack Obama will take office after a campaign that was pathbreaking on many levels. The argument here, necessarily somewhat speculative, is that Obama's management of his racial identity and of racial politics is roughly predictive of his soon-to-begin management of executive power in the United States. Obama is characterized as a “practical idealist,” a true pragmatist in the deeply grounded, philosophical (as opposed to vulgar) sense of that term. Attention is directed to the way Obama has handled or may be likely to handle the racial politics of the election itself, the ongoing realities of structural racism in the United States and the problem of exercising executive power in an endemically racial state, the role of race in national politics, and the role of race in global politics. The uniqueness of this new administration—headed by a preternaturally skilled and intellectually prepared Black politician—is not chiefly located in the symbolism of Obama's Blackness, important as that is. Rather it is Obama's formation as a Black intellectual and politician that may be expected to guide his thought and action in the White House.
A simulation-based model for understanding the time dependent x-ray drive asymmetries and error bars in indirectly driven implosions on the National Ignition Facility

Time-dependent low-mode asymmetries are believed to play a leading role in limiting the performance of current inertial confinement fusion implosions on the National Ignition Facility (NIF) [E. I. Moses et al., Phys. Plasmas 16, 041006 (2009)]. These long wavelength modes are initiated and driven by asymmetries in the x-ray flux from the hohlraum; however, the underlying hydrodynamics of the implosion also act to modify and amplify these asymmetries. We present here a simulation-based model connecting the time-dependent drive asymmetry seen by the capsule to the measured inflight and hot spot symmetries. This approach is based on a Green's function analysis for which we evaluate the response of the capsule to impulses of drive asymmetry at a series of times. Our model sheds new light on the sensitivity to the drive asymmetry of an imploded capsule, giving a new tool for design. Inverting the problem and finding the drive asymmetry needed to match the experimental data allow us to tightly constrain the drive asymmetry seen by the capsule, providing an error estimate on the result. Doing so, we are able to point out when and how the complex hohlraum simulations start to deviate from what they should obtain to match the experimental data. Ultimately, we project to use this model to make some experimental recommendations to fix the time-dependent low-mode asymmetry of indirectly driven implosions and identify additional measurements to further constrain the asymmetries with a view to improving target design on the NIF.Time-dependent low-mode asymmetries are believed to play a leading role in limiting the performance of current inertial confinement fusion implosions on the National Ignition Facility (NIF) [E. I. Moses et al., Phys. Plasmas 16, 041006 (2009)]. These long wavelength modes are initiated and driven by asymmetries in the x-ray flux from the hohlraum; however, the underlying hydrodynamics of the implosion also act to modify and amplify these asymmetries. We present here a simulation-based model connecting the time-dependent drive asymmetry seen by the capsule to the measured inflight and hot spot symmetries. This approach is based on a Green's function analysis for which we evaluate the response of the capsule to impulses of drive asymmetry at a series of times. Our model sheds new light on the sensitivity to the drive asymmetry of an imploded capsule, giving a new tool for design. Inverting the problem and ...