cssi/SciSciGPT-SciSciNet huggingface dataset:
Evaluation of the selective detachment process in flotation froth

Abstract The improved selectivity between particles of varying degrees of hydrophobicity in flotation froths has been well documented in literature, especially in the deep froths utilized in flotation columns. The phenomenon is believed to be due to the selective detachment process whereby the least hydrophobic particles are released from the bubble surface upon bubble coalescence. To quantify the selective detachment process, column flotation experiments were performed under various operating conditions that provided varying amounts of reflux between the froth and collection zones. Entrainment was eliminated by the use of relatively coarse 250 × 75 micron material. The flotation column incorporated the ability to provide instantaneous stoppage of the process streams and separation between the collection and froth zones after ensuring steady-state operation of the column. The samples collected from the two zones and process streams were evaluated to quantify the flotation rate distribution of the particles comprising each sample. The flotation rate was used as an indicator of the degree of hydrophobicity and thus a relative measure of the binding force between the particle and bubble in the froth zone. The flotation rate data was used as input into well known flotation models to obtain the froth zone recovery rate and the quantity of material that refluxes between the collection and froth zones.
Augmentation of mouse natural killer cell activity by combined hyperthermia and streptococcal preparation, OK-432 (Picibanil) treatment.

It has previously been demonstrated that the local administration of OK-432 (Picibanil) enhances the response of a murine tumour and normal tissue to elevated temperatures. The experimental animals were C3Hf/Sed mice and the tumours were the fourth generation isotransplants of a spontaneous non-immunogenic fibrosarcoma, FSa-II. The thermal enhancement ratio was greater for the tumour than for normal tissue, resulting in a favourable differential effect between normal and malignant tissues. Further studies were conducted to disclose the mechanism of OK-432 induced thermal enhancement. Although OK-432 showed a slight direct cytotoxic activity against tumour cells in vitro, the in vivo antitumour effect of combined OK-432 and hyperthermia treatments was greater than the effect expected from in vitro cytotoxicity, indicating the involvement of the host-mediated mechanisms. Whole body irradiation (WBI), which suppressed the host's immune reaction, did not affect the thermal enhancement mediated by OK-432, sugg...
Dynamic Scaffolding in a G Protein-Coupled Signaling System

The INAD scaffold organizes a multiprotein complex that is essential for proper visual signaling in Drosophila photoreceptor cells. Here we show that one of the INAD PDZ domains (PDZ5) exists in a redox-dependent equilibrium between two conformations--a reduced form that is similar to the structure of other PDZ domains, and an oxidized form in which the ligand-binding site is distorted through formation of a strong intramolecular disulfide bond. We demonstrate transient light-dependent formation of this disulfide bond in vivo and find that transgenic flies expressing a mutant INAD in which PDZ5 is locked in the reduced state display severe defects in termination of visual responses and visually mediated reflex behavior. These studies demonstrate a conformational switch mechanism for PDZ domain function and suggest that INAD behaves more like a dynamic machine rather than a passive scaffold, regulating signal transduction at the millisecond timescale through cycles of conformational change.
Centralized small-cell radio access network with shared millimeter-wave radio-over-fiber resources

Centralized radio access networks (RANs) based on radio-over-fiber (RoF) techniques can simplify the remote access units (RAUs) and maximize the resource sharing among services and operators, thus improving the system efficiency and reducing the operational cost. A scheme of resource sharing is proposed for centralized RANs based on millimeter-wave (MMW) RoF system. Both RoF infrastructure resources and microwavephotonics resources are shared by multiple operators in the heterogeneous system. High-throughput services carried on both V-band (60GHz) and W-band (100GHz) are delivered to RAUs through flexible configuration at the central office (CO). This proposed multi-service centralized RAN with shared infrastructure is successfully demonstrated via both simulations and experiments.
Concept Classification Using a Hybrid Data Mining Model

Apriori is a well-known algorithm which is used extensively in market-basket analysis and data mining. The algorithm is used for learning association rules from transactional data bases and is based on simple counting procedures. In this paper we propose enhancements to Apriori which allow it to perform concept classification similar to the way decision tree algorithms learn. Specifically, training examples are modified and treated as transactional data and the results are verified and further improved by C4.5 decision tree and k-means clustering algorithms, respectively. To demonstrate the novelty of the enhanced Apriori algorithm, we present a hybrid data mining model (HDMM) which identifies at-risk students based on their academic performance and other pertinent data.
Uniqueness of oral contraceptive progestins.

Gonane progestins are more potent and except for levonorgestrel less androgenic than the estrane progestins that preceded them. The current informal method for classifying oral contraceptives (OCs) as old first generation or second generation on the basis of their date of introduction obscures the fact that each of the gonane progestins has unique biologic properties. Recommended instead is the classification of OCs according to their level of androgenicity. Under such a system norgestimate desogestrel and monophasic norethindrone (0.4-0.5 mg) would fall into the low category. Triphasic levonorgestrel norethindrone (1.0 mg) norethindrone acetate (1.0 mg) and ethynodiol diacetate (1.0 mg) would be classified as having medium androgenicity while norgestrel (0.3 mg) norethindrone acetate (1.5-2.5 mg) and levonorgestrel (0.15 mg) would fall into the high androgenicity category.
A framework for computing the outcome of proxied combinatorial auctions

Proxy bidding has been proposed for combinatorial auctions as a means to speed up the auctions, to simplify the user interface, and to limit strategic behavior. The only previously known solution method for proxy bidding in combinatorial auctions requires the auctioneer to run the auction with myopic bidders to determine the outcome. In this paper we present a radically different approach that computes the bidders' allocation of their attention across the bundles only at the points at which they change their bidding patterns. This algorithm has several advantages over alternatives, including that it computes exact solutions and is invariant to the magnitude of the bids. We present a general framework and apply it to Ausubel and Milgrom's APA mechanism and our own simple combinatorial proxy auction. We present an example in which the approach is applied to a multistage proxy auction, and report on some preliminary computational results.
SAP Facilitates Recruitment and Activation of LCK at NTB-A Receptors during Restimulation-Induced Cell Death

Upon TCR restimulation, activated, cycling T cells can undergo a self-regulatory form of apoptosis known as restimulation-induced cell death (RICD). We previously demonstrated that RICD is impaired in T cells from patients with X-linked lymphoproliferative disease, which lack SLAM-associated protein (SAP) expression. Both SAP and the specific SLAM receptor NK, T, and B cell Ag (NTB-A) are required for RICD, but the mechanism by which these molecules promote a strong, proapoptotic signal through the TCR remains unclear. In this article, we show that the Src-family kinase LCK, but not FYN, associates with NTB-A in activated human T cells. This association increased after TCR restimulation in a SAP-dependent manner, requiring both immunoreceptor tyrosine-based switch motifs in the NTB-A cytoplasmic tail. Both NTB-A-associated LCK phosphorylation and kinase activity were enhanced in restimulated T cells, amplifying proximal TCR signaling. In contrast, TCR-induced LCK association with NTB-A, as well as phosphorylation and kinase activity, was reduced in T cells from patients with X-linked lymphoproliferative disease or normal T cells transfected with SAP-specific small interfering RNA, consistent with RICD resistance. Collectively, our data reveal how SAP nucleates a previously unknown signaling complex involving NTB-A and LCK to potentiate RICD of activated human T cells.
Mutable R-navajo alleles of cyclic origin in maize.

The generation in cyclic fashion of 26 mutable R-Navajo (mRnj) alleles in maize involved transposition of a non-specific repressor of gene action, Modulator (Mp), first away from, and then back to, the R locus represented by the R-Navajo (Rnj) allele on chromosome 10. The mRnj alleles reconstituted in this way varied widely, and continuously, in mutability to Rnj—that is, in transposition of Mp away from the R locus, thus derepressing the Rnj gene. They were alike, or nearly so, however, in activating Ds chromosome breakage and in increasing the stability of variegated pericarp, another unstable compound allele comprising Mp conjoined with Prr on chromosomal 1. These latter two phenomena are based primarily on loci elsewhere in the genome. It is postulated that the 26 reconstituted mRnj alleles carry a common Mp which, however, is intercalated at a different site within each allele. Nucleotide sequence in the regions adjacent to Mp is assumed to determine the frequency with which a form of micro-nondisjunction occurs whereby Mp is released from a donor site. Transposition to a new site is interpreted in terms of a chromosome model that gives effect to nicking, or single strand breaks, occurring throughout the genome as a prerequisite to unwinding, strand separation, and replication, of the DNA double helix.
Cell adhesion of Shewanella oneidensis to iron oxide minerals: Effect of different single crystal faces

The results of experiments designed to test the hypothesis that near-surface molecular structure of iron oxide minerals influences adhesion of dissimilatory iron reducing bacteria are presented. These experiments involved the measurement, using atomic force microscopy, of interaction forces generated between Shewanella oneidensis MR-1 cells and single crystal growth faces of iron oxide minerals. Significantly different adhesive force was measured between cells and the (001) face of hematite, and the (100) and (111) faces of magnetite. A role for electrostatic interactions is apparent. The trend in relative forces of adhesion generated at the mineral surfaces is in agreement with predicted ferric site densities published previously. These results suggest that near-surface structure does indeed influence initial cell attachment to iron oxide surfaces; whether this is mediated via specific cell surface-mineral surface interactions or by more general interfacial phenomena remains untested.
Creating Communities of Readers: A Study of Children's Information Networks as Multiple Contexts for Responding to Texts

This case study explores the perspectives of a group of sixth-grade language arts students concerning their views of the contexts of reading and responding to books in school. The researcher took the role of participant-observer and characterizes this study as a qualitative interpretive case study. As participant-observer, the researcher collected data in the form of fieldnotes, interviews, and written responses; the researcher analyzed data using the constant comparison method. Results of the study indicated that in this setting children respond to texts differently in the contexts under which they read and write about books. There were four different classroom contexts for responding to books in school: "silent" reading, book selection, writing, and aesthetic activity. Three conclusions were drawn from the study and make up an emerging grounded theory: (a) Children respond to books in patterns specific to school contexts, (b) Classroom contexts for reading and responding to books are socially constructed through children's interactions, and (c) Children constructed a community of readers by interacting with one another to respond to books in socially constructed contexts serving as information networks. This study was inspired first by my own love of books and reading and second, by the work of Galda (1988) who suggests that readers' responses to books are influenced by the nature of the reader, the text, and the context. We seem to know more about readers and texts than we do contexts for responding to books. Specifically, there seems to be a need for an investigation of the social construction of the contexts for reading and responding to books. Thus, this study was conducted to
THE SUSCEPTIBILITY OF INFANT RHESUS MONKEYS TO POLIOMYELITIS VIRUS ADMINISTERED BY MOUTH : A STUDY OF THE DISTRIBUTION OF VIRUS IN THE TISSUES OF ORALLY INFECTED ANIMALS.

Although rhesus monkeys have been generally regarded as refractory to infection with poliomyelitis virus administered by the oral route, two of seven infant rhesus developed paralytic poliomyelitis when fed murine-adapted strains of virus. Preliminary intranasal treatment with zinc sulfate and negative serial sections of the olfactory bulbs of the positive animals ruled out the possibility that infection occurred by way of the olfactory pathway. Studies on the distribution of virus in the tissues of the infected animals yielded positive results in one animal only. In this instance, virus was widely distributed throughout the body being isolated from spinal cord, buccal mucosa, duodenal wall, colon contents, superficial lymph nodes, spleen, heart, and adrenals.
Modulation of Dengue Virus Infection in Human Cells by Alpha, Beta, and Gamma Interferons

A role for interferon (IFN) in modulating infection by dengue virus (DV) has been suggested by studies in DV-infected patients and IFN receptor-deficient mice. To address how IFN modulates DV type 2 infection, we have assayed IFN-α, -β, and -γ for the ability to enhance or diminish antibody-independent and antibody-dependent cell infection using a competitive, asymmetric reverse transcriptase-mediated PCR (RT-PCR) assay that quantitates positive and negative strands of viral RNA, a flow cytometric assay that measures viral antigen, and a plaque assay that analyzes virion production. Our data suggest that IFN-α and -β protect cells against DV infection in vitro. Treatment of hepatoma cells with IFN-α or -β decreases viral RNA levels greater than 1,000-fold, the percentage of cells infected 90 to 95%, and the amount of infectious virus secreted 150- to 100,000-fold. These results have been reproduced with several cell types and viral strains, including low-passage isolates. In contrast, IFN-γ has a more variable effect depending on the cell type and pathway of infection. Quantitative RT-PCR experiments indicate that IFN inhibits DV infection by preventing the accumulation of negative-strand viral RNA.
Automating the Bureaucracy: Using McDonaldization Theory to comprehend the future evolution of E-Government

Sociologist George Ritzer has written extensively on the phenomenon of ‘ McDonaldization’ occurring in various facets of the American life experience, and increasingly around the world. This paper posits that the current interest in E-Government may be considered a new front in the trend towards McDonaldization, in this case the McDonaldization of government. Concepts from Ritzer's theory are used to demonstrate why E-Government may be considered an effort to foster McDonaldization of government; and to explore what this may mean for the future of government. It is proposed that McDonaldization can serve as a useful paradigm and framework for E-Government research; and that by familiarizing themselves with Ritzer's McDonaldization thesis, researchers in E-Government should be able to glean useful insights that can help them during the course of their research.
Organizing and sharing distributed personal web-service data

The migration from desktop applications to Web-based services is scattering personal data across a myriad of Web sites, such as Google, Flickr, YouTube, and Amazon S3. This dispersal poses new challenges for users, making it more difficult for them to: (1) organize, search, and archive their data, much of which is now hosted by Web sites; (2) create heterogeneous, multi-Web-service object collections and share them in a protected way; and (3) manipulate their data with standard applications or scripts.In this paper, we show that a Web-service interface supporting standardized naming, protection, and object-access services can solve these problems and can greatly simplify the creation of a new generation of object-management services for the Web. We describe the implementation of Menagerie, a proof-of-concept prototype that provides these services for Web-based applications. At a high level, Menagerie creates an integrated file and object system from heterogeneous, personal Web-service objects dispersed across the Internet. We present several object-management applications we developed on Menagerie to show the practicality and benefits of our approach.
Words without Mind

A woman (LR), unconscious for 20 years, spontaneously produces infrequent, isolated words unrelated to any environmental context. Fluorodeoxy-glucose-positron emission tomography (FDG-PET) imaging coregistered with magnetic resonance imaging (MRI) revealed a mean brain metabolism equivalent to deep anesthesia. Nevertheless, PET imaging demonstrated islands of modestly higher metabolism that included Broca's and Wernicke's areas. Functional brain imaging with magnetoencephalographic (MEG) imaging, a technique providing a temporal resolution of better than 1 msec, identified preserved dynamic patterns of spontaneous and evoked brain activity in response to sensory stimulation. Specifically, we examined spontaneous gamma-band activity (near 40 Hz) and its reset or modification during early auditory processing, a measure that correlates with human perception of sensory stimuli (Joliot, Ribary,& Llinas, 1994). Evidence of abnormal and incomplete gamma-band responses appeared in the left hemisphere only in response to auditory or somatosensory stimulation. MEG single-dipole reconstructions localized to the auditory cortex in the left hemisphere and overlapped with metabolically active regions identified by FDG-PET. The observation demonstrates that isolated neuronal groups may express well-defined fragments of activity in a severely damaged, unconscious brain. The motor fixed-action pattern character of her expressed words supports the notion of brain modularity in word generation.
A Numerical Study of the Effect of Upper-Ocean Shear on Flexible Drogued Drifters

Abstract The shape and slip of freely drifting, two-dimensional, flexible weighted drogues tethered to a surface buoy in a specified upper-ocean velocity profile are examined numerically. A simple analytic solution for a drogue in a linear shear flow, in the limit of small deviations from a straight vertical configuration, is used to identify the parameters of the problem and to predict the functional dependence of the slip and shape of the drogue on those parameters. The numerical computations, using a finite elements static equilibrium model, confirm the functional dependence predicted by the analytic solution and estimate the parametric dependences. However, a linear shear is not the “worst case” shear one needs to design for. In optimizing a drogue for linear shear, one can make use of the symmetry of the velocity profile to minimize the slip. The design problem arises from not knowing a priori the shear for which one is designing (especially since a drogue eventually moves far from its deployment sit...
Extra-high frequency hearing loss and hyperlipidemia.

Auditory thresholds in the extra-high frequency (EHF) range (10-18 kHz) were determined for twenty normal and twenty hyperlipidemic subjects. Subjects all passed a standard frequency auditory screening; all were otologically normal; all were aged between 20 and 50 years; none had a positive history of noise exposure. Modest, although significant, relationships were found between serum lipid levels and EHF acuity. Right ear thresholds and thresholds at 14 kHz showed the larger differences between the normals and hyperlipidemics
Editorial: Implementing the Teacher Education Initiative

Representatives from ten specialty professional associations affiliated with the National Technology Leadership Coalition (NTLC) are collaborating with Microsoft Corporation to develop an innovative professional development opportunity for teacher educators—the Teacher Education Initiative (TEI). The goal of the initiative is to enhance preparation of future teachers to use technology in effective ways to teach students across grades and academic disciplines. This effort builds upon initiatives such as Preparing Tomorrow’s Teachers to Use Technology (PT3) and Microsoft’s Partners in Learning (PIL) program.
Mitochondrial Function during and Regulation of Cardiac Development

The roles played by mitochondria during cardiac development are poorly understood. However, recent data has suggested that mitochondria are vitally important for normal formation and function of the heart in the embryo, the fetus, and the neonate. As the heart develops, mitochondrial ATP production becomes increasingly important, while mitochondrial regulation of the cellular redox state is important for cardiac myocyte differentiation. The mechanisms that control mitochondrial function during this period are becoming clearer and may include changes in protein acetylation, permeability transition pore activity, assembly of the electron transport chain, and mitochondrial dynamics and biogenesis.
Residues of Gardona in the body tissues and eggs of laying hens exposed to treated litter and dust boxes for control of external arthropod parasites.

Gardona® (2-chloro-1-(2,4,5-trichlorophenyl) vinyl dimethyl phosphate) placed in dust-bath boxes and in floor litter in chicken houses for 4 weeks produced maximum residues of 0.058 ppm in the back skin and 0.048 ppm in the body fat of chickens. Also, 6 samples of egg white contained residues ranging from 0.003 to 0.022 ppm, and 1 sample of egg yolk had a residue of 0.003 ppm. No residues were detectable in eggs or tissues the 2nd week after the insecticide was removed from the houses. Gardona, as used, had no apparent ill effect on the birds.
Socio-demographic differences in energy drink consumption and reasons for consumption among US college students:

Background:Energy drink consumption has become increasingly prevalent among US college students, yet little is known about current rates of consumption and reasons for consumption among current ene...
Cutaneous heat receptors in primates

In preparations from the saphenous nerve and the superficial branch of the radial nerve in Rhesus monkeys (Macaca mulatta), afferent impulses could be recorded during moderate warming of the skin. Single warm fibres serving the back of the hand and the foot had spot-like peripheral fields which were not excited by mechanical stimulation. Multi-fibre preparations excited by mild warming were also obtained, indicating a relatively dense distribution of warm receptors. At constant temperatures from 32° C on, single warm fibres showed a static discharge with a maximum frequency up to 20 impulses/sec in the range between 40 and 44° C. At higher temperatures the frequency decreased again, the discharge often changing from a regular sequence of impulses to an irregular type or a series of periodic bursts. Rapid warming caused an overshoot, rapid cooling a transient inhibition of the warm receptor discharge.
Development of an Ion Chromatography–Inductively Coupled Plasma–Mass Spectrometry Method To Determine Inorganic Arsenic in Liver from Chickens Treated with Roxarsone

Roxarsone, (4-hydroxy-3-nitrophenyl)arsonic acid, is an arsenic-containing compound that has been approved as a feed additive for poultry and swine since the 1940s; however, little information is available regarding residual arsenic species present in edible tissues. We developed a novel method for the extraction and quantification of arsenic species in chicken liver. A strongly basic solution solubilized the liver, and ultrafiltration removed macromolecules and particulate material. Ion chromatography separated the species [arsenite, arsenate, monomethylarsonic acid, dimethylarsinic acid, (4-hydroxy-3-aminophenyl)arsonic acid, (4-hydroxy-3-acetaminophenyl)arsonic acid, and roxarsone] in the extracts, which were then detected by inductively coupled plasma-mass spectrometry. The extraction oxidized most arsenite to arsenate. For fortification concentrations at 2 μg kg(-1) and above, recoveries ranged from 70 to 120%, with relative standard deviations from 7 to 34%. We detected roxarsone, its 3-amino and 3-acetamido metabolites, inorganic arsenic, and additional unknown arsenic species in livers from roxarsone-treated chickens. Both the originating laboratory and a second laboratory validated the method.
Study on the risk of the vector borne disease in the urban area based on the risk assement index matrix

Objective To establish the risk assessment indicator system for the vector borne disease in the urban area for practical use. Methods The Delphi method was used to determine the influencing factors and their hazard severity. The risk matrix was used to evaluate the risk scales of the vector borne disease. Results This risk assessment indicator system included 4 kinds of first level indexes,and were divided into 21 kinds of second level indexes on the aspect of the risk probability. Six kinds of indexes were also included on the aspect of the risk hazard severity in this system. Weightings of each index were determined by the Expert Arrangement Method. Meanwhile,the evaluation of the dengue fever in Nanchang city was in low risk level by this indicator system. Conclusions The indicator system is practical and objective and can be used for evaluation of the risks of other vector borne diseases.
Evolutionary optimization for parameterized whole-body dynamic motor skills

Learning a parameterized skill is essential for autonomous robots operating in an unpredictable environment. Previous techniques learned a policy for each example task individually and constructed a regression model to map between task and policy parameter spaces. However, these techniques have less success when applied to whole-body dynamic skills, such as jumping or walking, which involve the challenges of handling discrete contacts and balancing an under-actuated system under gravity. This paper introduces an evolutionary optimization algorithm for learning parameterized skills to achieve whole-body dynamic tasks. Our algorithm simultaneously learns policies for a range of tasks instead of learning each policy individually. The problem can be formulated as a nonconvex optimization whose solution is a closed segment of curve instead of a point in the policy parameter space. We develop a new optimization algorithm which maintains a parameterized probability distribution for the entire range of tasks and iteratively updates the distribution using selected elite samples. Our algorithm is able to better exploit each sample, greatly reducing the number of samples required to optimize a parameterized skill for all the tasks in the range of interest.
Third Parties in American Politics

Third parties have been, and continue to be, part of our political culture. To understand the two-party system, we need to know the roles which these third parties play They are important because they have become fairly frequent phenomena, because they reveal the vulnerabilities of the two major parties, and because they can influence the results of elections and the direction of public policy Rather than criticize them, we should understand their contribution to the dynamism of our politics. And finally, studying them can help us understand how and why the two party system has survived as long as it has.
The Costs and Benefits of Ethics Laws

This chapter assesses the impact of ethics laws at the state level in the U.S., focusing on laws that apply specifically to one category of public officials: legislators. I first discuss the positive contribution of ethics laws to the functioning of democratic government. I then turn to the costs of the laws, which are often subtle and counterintuitive. The discussion of the costs of ethics laws draws on a growing body of empirical evidence, and highlights the ways that legislation can have unintended and undesirable consequences.
Roux-en-Y gastric bypass augments the feeding responses evoked by gastrin-releasing peptides

Abstract Background Roux-en-Y gastric bypass (RYGB) is the most effective method for the treatment of obesity, and metabolic disease RYGB may reduce body weight by altering the feeding responses evoked by the short-term satiety peptides. Materials and methods Here, we measured meal size (MS, chow), intermeal interval (IMI) length, and satiety ratio (SR, IMI/MS; food consumed per a unit of time) by the small and the large forms of gastrin-releasing peptide (GRP) in rats, GRP-10 and GRP-29 (0, 0.1, 0.5 nmol/kg) infused in the celiac artery (CA, supplies stomach and upper duodenum) and the cranial mesenteric artery (CMA, supplies small and large intestine) in an RYGB rat model. Results GRP-10 reduced MS, prolonged the IMI, and increased the SR only in the RYGB group, whereas GRP-29 evoked these responses by both routes and in both groups. Conclusions The RYGB procedure augments the feeding responses evoked by exogenous GRP, possibly by decreasing total food intake, increasing latency to the first meal, decreasing number of meals or altering the sites of action regulating MS and IMI length by the two peptides.
Introduction Rethinking Dubliners : A Case for What Happens in Joyce’s Stories

More than a century ago, James Joyce published Dubliners, and since then, readers, scholars, and academics have vigorously discussed and interpreted the stories and the collection from perspectives that have become by 2016, it seems to us, in need of reorientation. Readers have come not only to accept these readings, but also to internalize them, understanding them as a kind of gospel truth. In Rethinking “Dubliners,” the editors take up a challenge that Fritz Senn gave Joyceans at the end of the twentieth century, hoping to put “descriptive possibility” not just on the critical periphery of writing about Dubliners, but also at the front and center, as a necessary movement forward in scholarly approaches to Joyce’s famous stories. Moreover, in the centenary year of the 1916 Easter Rising in Ireland and just over one hundred years after Joyce gave us our beloved short stories, we urge readers of Dubliners to reconsider the traditional tropes of paralysis and stagnation in favor of movement and change.
Post-Colonization Interval Estimates Using Multi-Species Calliphoridae Larval Masses and Spatially Distinct Temperature Data Sets: A Case Study

Common forensic entomology practice has been to collect the largest Diptera larvae from a scene and use published developmental data, with temperature data from the nearest weather station, to estimate larval development time and post-colonization intervals (PCIs). To evaluate the accuracy of PCI estimates among Calliphoridae species and spatially distinct temperature sources, larval communities and ambient air temperature were collected at replicate swine carcasses (N = 6) throughout decomposition. Expected accumulated degree hours (ADH) associated with Cochliomyia macellaria and Phormia regina third instars (presence and length) were calculated using published developmental data sets. Actual ADH ranges were calculated using temperatures recorded from multiple sources at varying distances (0.90 m–7.61 km) from the study carcasses: individual temperature loggers at each carcass, a local weather station, and a regional weather station. Third instars greatly varied in length and abundance. The expected ADH range for each species successfully encompassed the average actual ADH for each temperature source, but overall under-represented the range. For both calliphorid species, weather station data were associated with more accurate PCI estimates than temperature loggers associated with each carcass. These results provide an important step towards improving entomological evidence collection and analysis techniques, and developing forensic error rates.
Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury

Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective activities. It has been shown to target multiple secondary injury mechanisms in spinal cord injury, via its anti-inflammatory, anti-oxidant, and anti-apoptotic properties. The secondary injury mechanisms that MH can potentially target include inflammation, free radicals and oxidative stress, glutamate excitotoxicity, calcium influx, mitochondrial dysfunction, ischemia, hemorrhage, and edema. This review discusses the potential mechanisms of the multifaceted actions of MH. Its anti-inflammatory and neuroprotective effects are partially achieved through conserved mechanisms such as modulation of p38 mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Akt signaling pathways as well as inhibition of matrix metalloproteinases (MMPs). Additionally, MH can directly inhibit calcium influx through the N-methyl-D-aspartate (NMDA) receptors, mitochondrial calcium uptake, poly(ADP-ribose) polymerase-1 (PARP-1) enzymatic activity, and iron toxicity. It can also directly scavenge free radicals. Because it can target many secondary injury mechanisms, MH treatment holds great promise for reducing tissue damage and promoting functional recovery following spinal cord injury.
High-Throughput Robotic Phenotyping of Energy Sorghum Crops

Plant phenotyping is a time consuming, labour intensive, error prone process of measuring the physical properties of plants. We present a scalable robotic system which employs computer vision and machine learning to phenotype plants rapidly. It maintains high throughput making multiple phenotyping measurements during the plant lifecycle in plots containing thousands of plants. Our novel approach allows scanning of plants inside the plant canopy in addition to the top and bottom section of the plants. Here we present our design decisions, implementation challenges and field observations.
Coordinated Investment in Transmission and Storage Systems Representing Long- and Short-Term Uncertainty

In this paper, the coordinated investment in transmission and storage systems under uncertainty is addressed from the perspective of a central planner. The problem is formulated with the objective of achieving an effective expansion of both transmission and storage that minimizes the investment cost, while achieving an effective operation of a power system with high penetration of renewable power. The problem is stated within an adaptive robust optimization framework that incorporates stochastic modeling. Future available generation capacity and peak load in the target year (long-term uncertainty) are modeled using a robust set, while daily operating conditions (short-term uncertainty) are represented with a scenario set. The expansion tradeoff between transmission and storage systems is analyzed using the IEEE RTS 24-bus and IEEE 118-bus networks.
Principled, Professional, and Personal Integration and Beyond: Further Reflections on the past and Future:

This article contains the author's further reflections on integration and beyond (Tan, 2001), covering both the past and future, in celebration of 40 years of publication of the Journal of Psycholo...
Organizational Adaptation Under Stress: Tracing Communication Processes in Four California County Health Departments During the H1N1 Threat, April 28, 2009, to March 11, 2011:

Urgent public health threats present a growing problem for public health surge. This study addresses tensions that occur in organizations as they confront unexpected, urgent demands for performance that exceed their existing allocation of resources and personnel, patterns of adaptation in response, and consequences for continued functionality in their mission. We view the problem through a conceptual lens of complex adaptive systems and distributed cognition to focus on patterns of organizational communication as critical factors in shaping organizational response to crisis operations. We employ a mixed-methods approach to examine communication and coordination patterns in a small-N comparative case study of four California county health departments during the H1N1 threat in late spring–summer of 2009 and the following 24 months. Findings indicate factors that contribute to, or inhibit, the communication process, such as organizational structure, past experiences, exercise of authority, and document the o...
Abstract 1268: Anti-PD-1 monotherapy outperforms multiple immunotherapy combination strategies in an oral cancer prevention mouse model

Oral premalignant lesion (OPL) expression of PD-L1 is associated with increased cancer risk. These data suggest that immune evasion is already present at the OPL stage and warrant an evaluation of immune modulatory therapies for cancer prevention. We conducted this preclinical study in a carcinogen-induced mouse model of oral cancer to evaluate the efficacy of multiple immunomodulatory strategies, given at a time point when only OPLs are present, to reduce the incidence of oral squamous cell carcinoma (OSCC). We treated C57BL/6 mice with the carcinogen 4-nitroquinoline 1-oxide (4-NQO) for 8 weeks in drinking water. Eight weeks after discontinuing 4-NQO treatment, a group of mice (N=6) was sacrificed for assessment of invasive and non-invasive tongue lesions. A second group of mice was treated with either anti-PD-1 (N=40), anti-CTLA-4 (N=20), anti-OX40 (N=20), anti-PD-1 + anti-CTLA-4 (N=20), anti-PD-1 + anti-OX40 (N=20) antibodies, or IgG (N=40) for a total of 3 doses every 3 days, initiating 8 weeks after the cessation of 4-NQO. Antibodies used in combination were given on the same day . Mice were sacrificed 56 days after the last dose of treatment. We assessed serial HE p= 0.018). At this time point, invasive oral cancers had developed in 75% versus 50% of IgG and anti-PD-1 treated mice, respectively (p=0.03). There were also non-significant decreases in the mean OSCC area in tongues from mice treated with anti-CTLA-4 (mean = 5.07 mm2), anti-OX40 (mean = 3.79 mm2) and anti-PD-1 + anti-CTLA-4 (mean = 3.86 mm2) antibodies when compared to mice treated with IgG (mean = 6.62 mm2) control. In the group treated with anti-PD-1 + anti-OX40 combination therapy, there was an increase in the mean OSCC area when compared to anti-PD-1 monotherapy (mean 3.53 mm2 versus 9.03 mm2), respectively (p= 0.01). Short-term anti-PD-1 immune checkpoint inhibitor therapy in the context of OPLs led to a reduction in the incidence of oral cancer. When comparing the mean area of OSCC in each group, anti-PD-1 monotherapy was superior to IgG and all other treatment strategies. Paradoxically, combining anti-OX40 and anti-PD-1 antibodies created an antagonizing effect on the therapy and increased total tumor burden when compared with anti-PD-1 monotherapy. Citation Format: Jose Augusto Monteiro de Oliveira Novaes, Marlese A. Pisegna, Alissa Poteete, Fahao Zhang, John V. Heymach, William N. William. Anti-PD-1 monotherapy outperforms multiple immunotherapy combination strategies in an oral cancer prevention mouse model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1268.
The predictive ability of entity-wide geographic sales disclosures: IAS 14R versus IFRS 8

Abstract This report examines the predictive value of geographic revenue disclosures under IFRS 8 in forecasting company revenues using four forecast models. The findings show that the predictive accuracy of IFRS 8 entity-wide geographic sales significantly outperform consolidated sales in forecasting consolidated sales one year out. The results indicate that the predictive ability of country specific entity wide geographic sales improves on average by six percent when geographic sales are reported for country of domicile or by each individually material country. The study also finds that geographic sales disclosures by companies located in countries with high and moderate enforcement regimes improve the predictive accuracy of geographic sales by five percent. These results provide evidence that the disclosure of finer geographic sales data is more decision useful and associated with improved predictive accuracy for large listed companies in Europe, Australia and New Zealand.
Essential Role of Histone Methyltransferase G9a in Rapid Tolerance to the Anxiolytic Effects of Ethanol.

Background Tolerance to ethanol-induced anxiolysis promotes alcohol intake, thus contributing to alcohol use disorder development. Recent studies implicate histone deacetylase-mediated histone H3K9 deacetylation in regulating neuropeptide Y expression during rapid ethanol tolerance to the anxiolytic effects of ethanol. Furthermore, the histone methyltransferase, G9a, and G9a-mediated H3K9 dimethylation (H3K9me2) have recently emerged as regulators of addiction and anxiety; however, their role in rapid ethanol tolerance is unknown. Therefore, we investigated the role of G9a-mediated H3K9me2 in neuropeptide Y expression during rapid ethanol tolerance. Methods Adult male rats were administered one injection of n-saline followed by single acute ethanol injection (1 g/kg) 24 hours later (ethanol group) or 2 injections (24 hours apart) of either n-saline (saline group) or ethanol (tolerance group). Anxiety-like behaviors and global and Npy-specific G9a and H3K9me2 levels in the amygdala were measured. Effects of G9a inhibitor (UNC0642) treatment on behavioral and epigenetic measures were also examined. Results Acute ethanol produced anxiolysis and decreased global H3K9me2 and G9a protein levels in the central and medial nucleus of the amygdala as well as decreased occupancy levels of H3K9me2 and G9a near a putative binding site for cAMP-response element binding protein on the Npy gene. Two identical doses of ethanol produced no behavioral or epigenetic changes relative to controls, indicating development of rapid ethanol tolerance. Interestingly, treatment with UNC0642, before the second ethanol dose reversed rapid ethanol tolerance, decreased global H3K9me2 and increased neuropeptide Y levels in the central and medial nucleus of the amygdala. Conclusions These results implicate amygdaloid G9a-mediated H3K9me2 mechanisms in regulating rapid tolerance to the anxiolytic effects of ethanol via neuropeptide Y expression regulation.
Addition of Tocilizumab to Cyclosporine/ MMF for Acute Graft-Vs-Host Disease (aGVHD) Prophylaxis in Adult Double Unit Cord Blood Transplant (dCBT) Recipients: Promising Preliminary Results of a Phase II Clinical Trial.

Background Adult dCBT recipients are at significant risk for aGVHD especially involving the GI tract. Investigation of augmented prophylaxis is indicated. Methods Based on adult donor allograft data (Kennedy et al, Lancet 2015; Drobyski et al Haematologica 2018), we are investigating the addition of a single dose of tocilizumab 8 mg/kg (cap 800mg) on day -1 to standard cyclosporine/ MMF starting day -3 in adult patients (pts) with hematologic malignancies undergoing intermediate intensity Cy 50/ Flu 150/ Thio 10/ TBI 400 dCBT. We report an interim analysis of the first 16 pts of a 27 pt phase II trial (NCT03434730). All pts received standard bacterial/ fungal prophylaxis & Letermovir if CMV seropositive. Results 16 pts [median 50 years (range 27-59), median 85 kg (range 59-125), 6 AML, 5 ALL, 2 MPAL, 2 MDS, 1 CML, median aaHCT-CI of 3 (range 0-6)] received double-unit CB grafts with a median CD34+ cell dose of 1.33 × 105/kg/unit (range 0.24-3.83) & median unit-recipient 8-allele HLA-match of 5/8 (range 3-6). Pt outcomes are shown (Table). All (100%) pts engrafted with a median neutrophil recovery of 26 days (range 19-40). 94% of pts engrafted platelets (median 44 days, range 32-59). All pts had single unit dominance (median day 28 blood winning unit chimerism 100% (range 58-100). Prior to engraftment, 11/16 (69%) had no neutropenic fever, 3/16 (19%) pts had fever with bacteremia, 1 pt (6%) had febrile neutropenia (duration 2 days) responding to antibiotics, & 1 pt (6%) had initial fever due to bacteremia followed by fever/ rash attributed to pre-engraftment syndrome (PES). An additional 2 pts developed rash without fever prior to engraftment attributed to PES. Thus, a total of 3/16 (19%) pts had PES (onset ranging 12-14 days). Ten pts developed grade II aGVHD (median onset 45 days, range 26-81) for a cumulative incidence of 63% (95%CI: 33-82). This was limited primarily to skin &/or the upper gut with one pt having stage I lower GI. No pt has developed grade III-IV aGVHD & no pt has had stage II-IV lower GI aGVHD to date (Figure). With a median follow-up of 147 days (range 74-214), 15 pts are alive & disease-free (1 death due to HHV-6 pneumonitis). Conclusions Preliminary data suggests tocilizumab is safe with no adverse effects upon engraftment or unit dominance. Tocilizumab mitigates PES (expected incidence 65% in dCBT controls, Bhatt et al, ASBMT 2019). Expected days of febrile neutropenia were also reduced especially given the prolonged neutrophil recovery. Notably, lower gut aGVHD appears markedly reduced with no cases of grade III-IV aGVHD or aGVHD mortality to date. Our findings appear consistent with the published adult donor data. Overall, one tocilizumab dose has improved the early post-dCBT morbidity & investigation of this promising & potentially cost-effective approach is ongoing.
Wireless Energy Harvesting in Massive MIMO with Low-Dimensional Digital Precoding

The objective of this paper is to analytically quantify the performance gap between the hybrid processing and full-dimensional (FD) digital processing for simultaneous wireless information and power transfer (SWIPT) in massive multiple-input multiple-output (MIMO) systems. To this end, a hybrid precoder&#x002F;combiner structure, which consists of a low-dimensional digital precoder&#x002F;decoder cascaded with an analog beamformer&#x002F;combiner, is employed at the base-station (BS) for SWIPT. For two hybrid processing designs, the harvested energy, achievable rates and fundamental energy-rate trade-off are derived when the number of BS antennas grows without bound with respective to the number of user nodes. Thereby, the percentage losses of the achievable rate and the harvested energy of the proposed hybrid precoding&#x002F;combining over the FD digital precoding&#x002F;combining are quantified. Our analysis and numerical results reveal that the proposed hybrid processing technique for SWIPT significantly reduces the number of radio frequency chains at the massive MIMO BS, while yielding only marginal energy-rate trade-off degradation over the FD digital counterpart.