cssi/SciSciGPT-SciSciNet huggingface dataset:
Implications of Alternative Cotton Acreage Allotment Levels

T HE many problems facing the cotton industry have caused much thought about alternative government programs for cotton. One objective of Southern Regional Research Project S-42 is to evaluate the effects of several alternative cotton acreage-allotment and price situations. Intensive studies are being made in most major cotton-producing areas. The results of these studies will be combined into a beltwide re-
Problem-Based Learning in the Family Sciences: A Good Fit in Theory and Practice

Problem-Based Learning (PBL) is a good fit for pedagogy in the family sciences due to the developmental and psychological theories that overlap with key features of PBL. Vygotsky's Zone of Proximal Development (ZPD) and "authentic problem solving" are examples of theories that explain how PBL works. These learner-centered pedagogies increase engagement and motivation by helping students learn to solve real-world problems. Furthermore, PBL has been shown to enhance professional practice and preparation for students as they enter the workforce. Examples of how instructors can apply PBL in family science college classrooms are offered. Furthermore, a graphic organizer is presented to compare and contrast similarities and differences between PBL and ZPD theories. A sample worksheet that can be used in the classroom is also included. The goal of this paper is to give instructors a sufficient understanding of PBL and plausible examples of how it might be used in the classroom.
α-Klotho in Health and Diseases

α-klotho - (α-kl) was first identified as an aging gene and later shown to be a regulator of calcium and phosphate homeostasis. α-kl is predominantly expressed in tissues that are involved in mineral homeostasis, and it encodes a 130-kDa type I glycoprotein. α-Kl was first predicted to localize to the cell surface. However, large amounts of α-Kl proteins have been detected in the intra-cellular space. In addition, the extra-cellular domain is cleaved, and secreted forms have been identified in the blood, CSF and urine. These findings suggest that α-Kl has several functions that depend on its intracellular, membrane, and extra-cellular secreted forms. In fact, the intra-cellular form of α-Kl activates Ca2+ transport from the blood to the CSF in the choroid plexus and Ca2+ re-absorption in the kidney and regulates PTH secretion in parathyroid glands by controlling the trafficking of the Na+-K+-ATPase complex to plasma membrane. On the membrane, α-Kl forms a ternary complex with FGF23 and FGFR1 and negatively regulates 1, 25(OH)2D synthesis and phosphate re-absorption in the kidney. As a down-steam event of hypervitaminosis D and hyperphosphatemia, Calpain-1 is greatly activated and is responsible for many phenotypes. Although a growing number of papers have reported the biological and clinical roles of the secreted form of α-Kl, the functions of the secreted form of α-Kl are poorly understood.
A Note on Mean Square Successive Differences

This paper deals with the use of higher order mean square successive differences for estimating dispersion when a strong trend is present in the mean value and the method of first differences does not adequately eliminate the trend. The first four moments of the mean square successive second difference, δ22, are derived in samples from an arbitrary population with constant mean (or with linear trend in the means). Because the efficiency of δ22 relative to δ22 increases with β2, the approximate distribution of δ22 is discussed only for a leptokurtic population, specifically for the symmetrical two-tailed exponential population. For populations with varying mean the first two moments of δ22 are given and the effect of trend of the mean values on these moments is discussed. Short tables of the efficiency of the mean square successive second, third, and fourth differences, all relative to s2 are given.
Food Counseling for Patients with AIDS

1. Sires LR, Hruby S, Alvord EC Jr, Hellstrom I, Hellstrom K-E, Kies MW, Martenson R, Deibler GE, Beckman ED, Casnellie JE. Species restrictions of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein. Science 1981;214:87-9 2. Reik L Jr, Smith L, Khan A, Nelson W. Demyelinating encephalopathy in Lyme disease. Neurology 1985;35:267-9 3. Sterman AB, Nelson S, Barclay P. Demyelinating neuropathy accompanying Lyme disease. Neurology 1982;32:1302-5 4. Suchanek G, Kristoferitsch W, Stanek G, Bernheimer H. Antimyelin antibodies in cerebrospinal fluid and serum of patients with meningopolyneuritis Garin-Bujadoux-Bannwarth and other neurological diseases. Zentralbl Bakteriol Mikrobiol Hyg [A] 1986;263:160-8 668 Correspondence
Context-Induced Parameter Instability in a Disaggregate-Stochastic Model of Store Choice:

A model of individual consumer choice is described which posits that the relative weights consumers associate with product attributes in forming preferences covary with the amount of variability on...
Evaluating an Online Stress Management Intervention for College Students

The goal of this study was to assess the feasibility and effectiveness of a theory-based online intervention designed to improve stress management in undergraduate students. The intervention focused on present control because it has been found to be associated with a range of positive outcomes, including lower levels of depression, anxiety, and stress, controlling for a range of other variables (e.g., Frazier et al., 2011, 2012). Two pilot studies were first conducted to confirm that our intervention could increase present control. We then randomly assigned psychology students (n = 292) who were prescreened to have lower scores on the present control subscale of the Perceived Control Over Stressful Events Scale (Frazier et al., 2011) to 1 of 3 conditions: the present control intervention, the present control intervention plus feedback, and stress-information only. Seventy-six percent (n = 223) began the intervention, and 87% (n = 195) of those completed the posttest and 3-week follow-up. The 2 present control intervention groups had lower levels of stress, depression, and anxiety symptoms (on the Depression Anxiety Stress Scales; Lovibond & Lovibond, 1995) and perceived stress (on the Perceived Stress Scale; Cohen, Kamarck, & Mermelstein, 1983) relative to the stress-information-only group at posttest and 3-week follow-up (mean between group d at follow-up = .35, mean within group d for intervention groups at follow-up = -.46). Further, mediation analyses revealed that these effects were mediated by changes in present control. Our intervention represents a potentially valuable tool for college mental health services.
REM Sleep without Atonia Severity Predicts Cognitive Impairment in REM Sleep Behavior Disorder (P7.307)

OBJECTIVE : We investigated whether REM sleep without atonia (RSWA) severity was associated with cognitive functioning in REM sleep behavior disorder (RBD). BACKGROUND : RBD is a potentially injurious parasomnia that is strongly associated with synucleinopathy. Patients with RBD exhibit RSWA, the loss of normal muscle atonia during REM sleep, on polysomnography (PSG). DESIGN/METHODS : Both idiopathic (iRBD) and symptomatic RBD (sRBD) patients completed two cognitive batteries: CNS Vital Signs (CNS-VS) and Useful Field of View (UFOV). All subjects underwent PSG and muscle (SM: submentalis; AT: anterior tibialis) tone during REM sleep was visually and automatically scored. Group differences between sRBD and iRBD were then compared, and regression models fit to determine the relationship of RSWA and dependent cognitive measures. RESULTS : Twenty iRBD and 10 sRBD participated. Demographics were similar between groups. Deficits on cognitive testing were observed on CNS-VS in processing (sRBD iRBD, all p<0.002). sRBD patients had greater combined phasic and tonic RSWA in SM (p=0.026) and longer mean phasic burst duration (p=0.03). Regression analyses demonstrated that SM RSWA independently predicted overall CNS-VS Neurocognitive Index (NCI) (F=4.5, p=0.006), adjusting for age, gender, depressive symptoms (Zung Score), and sleep disturbances (PSQI), and this relationship also remained significant for the iRBD group after excluding sRBD patients from analysis to account for the effect of co-morbid neurologic or cognitive disorders (F=3.5, p=0.03). SM RSWA was not predictive of total UFOV performance. CONCLUSIONS : RSWA is predictive of lower overall cognitive performance in patients with RBD. Future prospective analysis of a larger cohort is planned to determine whether RSWA may also predict other neurological signs of phenoconversion to overt synucleinopathy in iRBD patients. Study Supported by: UL1 RR024150-01. Disclosure: Dr. Sandness has nothing to disclose. Dr. St. Louis has received personal compensation for activities with Inspire, Inc. Dr. McCarter has nothing to disclose. Dr. Boeve has received research support from GE Healthcare. Dr. Silber has nothing to disclose.
Preliminary Report on Experiment of Medicament Control for Oidium monilioides

Oidium monilioides is an important disease of Jatropha carcass in Yongsheng county,which pathogenic bacteria usually infect stem and leaves of tender branches,.flower order and fruits.Infected ratio of severe stand can be as high as 100% and index of disease status as 70%.The experiment reveals occurrence period of Oidium monilioides starting from middle of May to early of July,vigorous period from middle of July to end of September,final phase from early of October to December.Moreover,effective medicament and density are followed as 15% of 400-600 times of wettable triadimefon powder,29% of 300-500 times of lime sulfur,50% of 250-1000 times of carbendazol and sulfur wettable powder.
Simultaneous Economic and Risk-Based Routing of Gas Pipelines

The current procedure used for the determination of the route of a pipeline starts by considering the economic considerations only followed by quantitatively assessing the risk of the proposed pipeline. In this work, we propose a new methodology that takes the economic and safety considerations simultaneously into account, and, thus, provide a more efficient method of establishing the route of gas pipelines.
Prevalence of Complementary and Alternative Medicine use among a Population of Head and Neck Cancer Patients: A Survey-Based Study:

We sought to determine the prevalence and patterns of complementary and alternative medicine (CAM) use among head and neck cancer patients who were being treated at an academic otolaryngology practice in the northeastern United States from January 2005 through December 2006. During a 3-month period, we conducted an anonymous survey of 213 new and established patients regarding their use of CAM during their cancer treatment. According to the responses, only 13 of these patients (6.1%) were currently using CAM during treatment. With respect to the various products being taken, 9 patients (69.2% of all CAM users) were taking herbs or supplements. Only 7 patients (53.8%) who used CAM disclosed this fact to their physician during in-office encounters. The most common sources for obtaining CAM were health-food stores, where most patients spent approximately $25 per week. The most frequently cited reason for using CAM was that a particular product had been recommended by family or friends as being potentially helpful. No adverse effects of CAM were reported. We conclude that while CAM use was not very prevalent in this study, patients who did use it were employing modalities with biologic activity that may potentially interact with conventional therapies. Because patients' disclosure of CAM use is frequently not volunteered, otolaryngologists should routinely elicit this information in a highly specific fashion so that we may better serve our unique patient population.
1975: Thoughts on Inflation: the Basic Forces

So much has been written and is currently being written on inflation that it is impossible to read everything and say anything that has not been said before. The best I can do under these circumstances is, I believe, not to comment on current events but to go back to basic principles which are often lost sight of in daily work, although they are frequently a better guide for things to come than minute description of current events and the extrapolation of recent trends.
Organizations That Help Women to Build STEM Careers

This chapter begins the second half of the book, which examines various case studies. The chapter is devoted to the descriptions and histories of four organizations that have worked to support increased numbers and better experiences for women in science and engineering careers. The chapter considers these organizations in the chronological order of their origins: the Society of Women Engineers (SWE 1950), the Association for Women in Science (AWIS 1971), the Women in Engineering ProActive Network (WEPAN 1990), and MentorNet (1997).
The Dynamic Motion and Delicate Control Of Vkor Catalysis

Vitamin K epoxide reductase (VKOR) is an intramembrane enzyme required for blood coagulation and is the target of the anticoagulant warfarin. The reduction of vitamin K epoxide is coupled with disulfide-bond formation at the active site of VKOR. To regenerate the active site, VKOR is reduced by protein partners that transfer electrons to VKOR. Here we report two crystal structures of a bacterial VKOR homolog with its reducing partner captured in different conformational states. These structures reveal a short helix at the hydrophobic active site of VKOR that undergoes stretching and compressing motions. Motions of this “horizontal helix” promote electron transfer to the VKOR active site by regulating the positions of two cysteines in an adjacent loop. Compression of the helix also separates the “loop cysteines” to prevent backward electron transfer. During these motions, hydrophobicity at the active site is maintained to facilitate vitamin K reduction. Biochemical experiments support the structural model and suggest that several warfarin-resistant mutations act by changing the conformation of the horizontal helix. Taken together, these structures provide a comprehensive understanding of electron transfer and vitamin K reduction catalyzed by VKOR. Disclosures: No relevant conflicts of interest to declare.
The morphosyntactic development of case in Down syndrome

Abstract The experimental research presented in this paper reports on findings from the study of case (syntactic and morphological) in 16 Cypriot Greek adults diagnosed with Down syndrome (DS) and 17 typically developing children. We perform phonetic and phonological analyses alongside morphosyntactic and syntactic analyses on data collected from eight experimental tasks. Results reveal near-ceiling performance for both groups. Syntactically conditioned differences related to structural complexity, problematic use of tense and subject-verb agreement or bundling/DP effects, are not recorded. We establish that the greater majority of differences observed between the two groups are mainly conditioned by articulatory limitations related to the distinct physiology associated with DS, as well as minor differences in their phonological systems. A small residue of differences that are determined to be morphosyntactic in nature is also recorded; these exhibit a clear systematicity in choosing the default case value (nominative), instead of the targeted one. Given the close to ceiling performance with case, morphosyntactic inaccuracies are determined to be neither due to lack of knowledge of the case assignment mechanisms, nor lack of knowledge of inflectional paradigms, but rather a morphological discrepancy, during the Vocabulary Insertion stage.
Quantitative imaging to evaluate malignant potential of IPMNs.

// Alexander N. Hanania 1,2 , Leonidas E. Bantis 3 , Ziding Feng 3 , Huamin Wang 4 , Eric P. Tamm 5 , Matthew H. Katz 6 , Anirban Maitra 4 and Eugene J. Koay 2 1 University of Texas Medical School, Houston, TX, USA 2 Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA 4 Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA 5 Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA 6 Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA Correspondence to: Eugene J. Koay, email: // Keywords : IPMN, quantitative imaging, radiomics, fukuoka, pancreatic cyst Received : July 06, 2016 Accepted : August 18, 2016 Published :August 31, 2016 Abstract Objective: To investigate using quantitative imaging to assess the malignant potential of intraductal papillary mucinous neoplasms (IPMNs) in the pancreas. Background: Pancreatic cysts are identified in over 2% of the population and a subset of these, including intraductal papillary mucinous neoplasms (IPMNs), represent pre-malignant lesions. Unfortunately, clinicians cannot accurately predict which of these lesions are likely to progress to pancreatic ductal adenocarcinoma (PDAC). Methods: We investigated 360 imaging features within the domains of intensity, texture and shape using pancreatic protocol CT images in 53 patients diagnosed with IPMN (34 “high-grade” [HG] and 19 “low-grade” [LG]) who subsequently underwent surgical resection. We evaluated the performance of these features as well as the Fukuoka criteria for pancreatic cyst resection. Results: In our cohort, the Fukuoka criteria had a false positive rate of 36%. We identified 14 imaging biomarkers within Gray-Level Co-Occurrence Matrix (GLCM) that predicted histopathological grade within cyst contours. The most predictive marker differentiated LG and HG lesions with an area under the curve (AUC) of .82 at a sensitivity of 85% and specificity of 68%. Using a cross-validated design, the best logistic regression yielded an AUC of 0.96 (σ = .05) at a sensitivity of 97% and specificity of 88%. Based on the principal component analysis, HG IPMNs demonstrated a pattern of separation from LG IPMNs. Conclusions: HG IPMNs appear to have distinct imaging properties. Further validation of these findings may address a major clinical need in this population by identifying those most likely to benefit from surgical resection.
Have a Scoop of Grandpa: Composting as a Means of Final Disposition of Human Remains

Many a religious tradition teaches that, upon death, our human souls are transported to another realm. Yet in the end, our physical bodies are nothing but a bag of bones. The body’s decay can be delayed by embalming, the death industry’s version of Botox and facial fillers, aimed at forestalling our inevitable decay and decline. The methods of final disposition of the body, burial, cremation, or the death industry’s newest innovation of alkaline hydrolysis, are variations on a theme – reduction of the physical body to fragments of bone. This Article examines mortality composting, the latest frontier in death care, and particularly, whether the law permits mortality composting as a method of final disposition of human remains. Likely because of its sheer novelty, the law's permissibility of the composting of human remains has yet to be explored in the legal academic literature. This Article argues that the split statutory approach to alkaline hydrolysis provides a useful framework for assessing the legality of composting as a means of final disposition. At first glance, the visual imagery of a human body - limbs askew - sticking out of a compost bin amidst the fodder of banana peels, eggshells, and coffee grounds, is disrespectful and distasteful. Imagine instead a respectful, dignified well-designed urban space, perhaps embellished tastefully by public art in memoriam to the lives lived. Moreover, in lieu of pumping the dead human body with chemicals in an attempt to inject the appearance of vim and vigor and then encasing it in tons of concrete, wood, and steel, mortality composting honors the human dead’s place in the cycle and recycling of life and its valuable role in enriching the earth. It transforms the body into humus, the rich organic material that enriches soil and allows water and nutrients to better penetrate plants, setting the stage for the literal flowering of new life.
Eating Disorders and Breast Cancer.

Background: Eating disorders such as anorexia nervosa and bulimia nervosa affect overall and reproductive health and may also affect breast cancer risk. We studied the association between self-reported eating disorders and breast cancer risk in a prospective cohort study. Methods: In 2003-2009, the Sister Study enrolled women aged 35-74 who had a sister with breast cancer but had never had it themselves. Using data from 47,813 women, we estimated adjusted hazard ratios (HR) and 95% confidence intervals for the association between eating disorders and invasive breast cancer over a median of 5.4 years of follow-up. Results: Three percent (n=1,569) of participants reported a history of an eating disorder. Compared to women who never had an eating disorder, women who reported eating disorders in the past had reduced breast cancer risk (HR=0.62, 95% CI: 0.42-0.92). Conclusions: In this large, prospective, observational cohort study, we observed an inverse association between having a history of an eating disorder and invasive breast cancer. Impact: Historical eating disorders may be associated with a long-term reduction in breast cancer risk. -
Abstract 5141: A comprehensive system of congenic mouse melanoma models for evaluation of immune therapies

Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA There has been longstanding interest in the relationship between the immune system and malignant melanoma, the deadliest form of skin cancer. Melanoma has been the tumor of choice for the evaluation of a wide variety of therapeutic approaches that rely on stimulation of the immune system to combat cancer. The striking responses to immune checkpoint inhibitors noted in some melanoma patients have now been observed in several other malignancies, including renal cell carcinoma, lung cancer, and prostate cancer. These findings are very encouraging, however the specific mechanisms of response and reasons why only a subset of patients respond to therapy are not known. The extraordinary potential of immune therapies in cancer suggests that human-relevant mouse models of cancer are required to understand mechanisms of response and to optimize therapy so that a larger proportion of patients respond. We have generated and evaluated a series of genetically engineered mouse models driven by alterations in Braf, Pten, Cdkn2a, beta catenin, p53, and Nras that reflect the genetic diversity of the vast majority of human melanoma. We have backcrossed 6 of these models to C57Bl/6, generated tumors, and isolated a series of over 20 congenic mouse melanoma cell lines. Several independent lines have been isolated for each melanoma genotype generated. Injection of these lines into C57Bl/6J mice results in reproducible tumor formation in the absence of co-injection of Matrigel. We are in the process of characterizing the tumor microenvironment in each of the models using flow cytometry and a novel quantitative imaging approach of histological sections, which produces flow cytometry-like data, but retains spatial and morphologic information that can be utilized to characterize much smaller tumors. This series of congenic lines represents an ideal set of models for the study of cancer immunology and responses to immune therapies. Citation Format: Katrina M. Meeth, William E. Damsky, Marcus Bosenberg. A comprehensive system of congenic mouse melanoma models for evaluation of immune therapies. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5141. doi:10.1158/1538-7445.AM2015-5141
Real-time measurement of small molecules directly in awake, ambulatory animals

The development of a technology capable of tracking the levels of drugs, metabolites, and biomarkers in the body continuously and in real time would advance our understanding of health and our ability to detect and treat disease. It would, for example, enable therapies guided by high-resolution, patient-specific pharmacokinetics (including feedback-controlled drug delivery), opening new dimensions in personalized medicine. In response, we demonstrate here the ability of electrochemical aptamer-based (E-AB) sensors to support continuous, real-time, multihour measurements when emplaced directly in the circulatory systems of living animals. Specifically, we have used E-AB sensors to perform the multihour, real-time measurement of four drugs in the bloodstream of even awake, ambulatory rats, achieving precise molecular measurements at clinically relevant detection limits and high (3 s) temporal resolution, attributes suggesting that the approach could provide an important window into the study of physiology and pharmacokinetics.
Persistent Symptoms After Antireflux Surgery and Their Management

At the end of this chapter, the reader will understand the prevalence of persistent symptoms following antireflux surgery, the most common symptoms reported, and the pre-operative risk factors that may predict the development of symptoms. The reader will also understand how to approach the work-up of persistent symptoms in an algorithmic fashion, and the common treatments to consider.
An implementable optimization of airfare structure

Pricing and especially fare structures have received little attention within the revenue management literature. For an airline, well-designed fare structures segment customers properly, selling to correct customers at intended prices. For a given origin and destination, the pricing manager seeks to maximize revenue by jointly optimizing all price levels in the airline’s menu of fares. Deterministic demand is modeled using booking periods as primary customer segments; inventory management is integrated as a secondary segmentation tool. Analytical solutions are attained under various demand functional forms, and comparative statics are juxtaposed to reveal characteristics of each demand type.
The Incidence of and Risk Factors for Postintubation Hypotension in the Immunocompromised Critically Ill Adult.

Objectives:Our primary aim was to ascertain the frequency of postintubation hypotension in immunocompromised critically ill adults with secondary aims of arriving at potential risk factors for the ...
Chapter 5 - Characterization of Model Nanocatalysts by X-ray Absorption Spectroscopy

Abstract Nanoparticles, due to their finite sizes, demonstrate enhanced catalytic properties compared with their bulk counterparts. In order to understand their mechanisms of work and design new and better nanocatalysts, fundamental understanding of the structural and electronic properties is required. Well-defined nanoclusters are most attractive for such purpose. Their unique shapes, compositional motifs, enhanced strain, electronic and structural heterogeneities, and their dynamic changes caused by the environment are all important descriptors of catalytic activity. The main challenge toward their systematic investigation is the scarcity of techniques that can characterize these attributes of structure with high spatial, energy, and temporal resolutions. In this chapter, we summarize a number of methods of extended X-ray absorption fine structure (EXAFS) spectroscopy recently developed for characterization of well-defined nanocatalysts. We demonstrate how EXAFS enables the determination of their structure, size, shape, and compositional motifs. We also describe challenges that impede accuracy of EXAFS methods and discuss corrective strategies.
Characterization of a geometrically constrained tripolar antenna under M2M channel conditions

Historically, antenna designs have been dictated by specific performance requirements for gain, beamwidth, return loss, etc. without consideration of the environment the antenna is being deployed in. Herein, we consider an over-the-air (OTA) approach for characterizing antenna performance for a wireless device arbitrarily deployed in a cluttered environment, e.g., a machine-to-machine (M2M) installation. We then explore antenna system geometries that can be cofabricated with the device's enclosure using 3D printing technologies. Based on a channel characterization study and fabrication constraints, we propose a tripolar antenna design that is readily integrated with, for example, a wireless sensor.
Algorithm and Constraints for Exact Non-blind Deconvolution

Image filtering is generally an irreversible process. Image restoration methods, such as inverse filtering or other deconvolution techniques, cannot precisely recover the original image and often introduce some level of artifacts. In the current paper, we formulate the filtering as a blending of several transformed replications of the original image. We assume zero noise after the filtering. Using this convention, we propose a method that precisely restores the original image from its filtered version. The method is applicable for a family of filters including average box filters and approximated Gaussian filters.
Porous carbon/CeO2 composites for Li-ion battery application

Development of new materials hold the key to the fundamental progress in energy storage systems such as Li-ion battery, which is widely used in modern technologies because of their high energy density and extended cycle life. Among these materials, porous carbon is of particular interest because it provides high lithiation and excellent cycling capability by shortening the transport length for Li+ ions with large electrode/electrolyte interface. It has also been demonstrated that transition metal oxide nanoparticle can enhance surface electrochemical reactivity and increase the capacity retention capability for higher number of cycles. Here we investigate porous carbon/ceria (CeO2) nanoparticles composites as an anode material. The high redox potential of ceria is expected to provide a higher potential window as well as increase the specific capacity and energy density of the system. Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM) is used for material characterization, while battery analyzer is used for measuring the electrochemical performance of the battery.
Abstract B157: Effect of HGF concentration on c-Met phosphorylation and inhibition in paracrine-activated tumor cells

c-Met is a receptor tyrosine kinase critical for embryogenesis and liver repair. In tumors, including breast, prostate, glioblastoma, and thyroid cancer, Met protein levels are often elevated and associated with disease progression and metastasis. The c-Met pathway is activated by the endogenous ligand hepatocyte growth factor (HGF). HGF is produced by mesenchymal cells and binds to the c-Met protein, leading to phosphorylation and upregulation of a variety of downstream signaling pathways that result in increased tumor cell migration, proliferation, survival, and induction of angiogenesis. Consequently, there has been significant interest in the development of c-Met inhibitors as anticancer therapeutics. The efficacy of such agents usually initially are determined in vitro utilizing HGF concentrations of 25-50 ng/mL. However, HGF serum levels in humans typically range from 0.4-0.8 ng/mL. To examine the impact of exogenous HGF levels on c-Met inhibitor activity, human prostate (PC-3, DU145) and lung (A549) cancer cell lines were utilized in this study. These cell lines have been previously characterized as paracrine-activated: cell lines that express the c-Met receptor, but not HGF. In the presence of 25-50 ng/mL HGF, these cell lines demonstrated a reduction in migration, invasion, and phosphorylation of Met after treatment with the small-molecule c-Met inhibitor BMS-777607. However, such antitumor efficacy was absent when these paracrine-activated cell lines were treated with BMS-777607 in the presence of physiologically normal concentrations of HGF (0.4-0.8 ng/mL). A human HGF-expressing mouse model has been developed for xenograft studies of human c-Met inhibition, on the basis that mouse HGF does not activate human c-Met. However, we found that mouse HGF was able to induce phosphorylation of Met in the human DU145 cell line. In vivo, DU145 xenografts in NSG mice treated with BMS-777607 showed no reduction in c-Met phosphorylation unless the mice were administered exogenous HGF during tumor growth. Taken together, these findings indicate that the utilization of nonphysiologic concentrations of HGF in tissue culture evaluations of c-Met targeting agents may result in an overestimation of agent activity not likely to be observed in the tumor microenvironment. Citation Format: Veronica S. Hughes, Dietmar W. Siemann. Effect of HGF concentration on c-Met phosphorylation and inhibition in paracrine-activated tumor cells [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2017 Oct 26-30; Philadelphia, PA. Philadelphia (PA): AACR; Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B157.
An Interprofessional Curriculum to Advance Relational Coordination and Professionalism in Early-Career Practitioners.

Introduction We created a curriculum to help new physicians and nurses develop skills in interprofessional collaboration. This modular, team-based curriculum for early practitioners delivered train...
Discussion: Rationale for the Psychotherapy of Schizophrenia

The authors of these four papers are clearly sensitive to close encounters with schizophrenic patients, and, despite the announced theme of the session, this may be one reason why none of them focused exclusively on the rationale for psychotherapy with schizophrenics. I think that most of us who have been in the field believe that the personally involving nature of the therapeutic experience really precludes any need to justify it. The possibility of intensive interaction constitutes its own rationale, because it contains an element of hope; with the prevalence and the devastating character of the disorder, no further justification is required.
Privacy-preserving location publishing under road-network constraints

We are experiencing the expanding use of location-based services such as ATST TeleNav GPS Navigator and Intel’s Thing Finder. Existing location-based services have collected a large amount of location data, which have great potential for statistical usage in applications like traffic flow analysis, infrastructure planning and advertisement dissemination. The key challenge is how to wisely use the data without violating each user’s location privacy concerns. In this paper, we first identify a new privacy problem, namely inference route problem, and then present our anonymization algorithms for privacy-preserving trajectory publishing. The experimental results have shown that our approach outperforms the latest related work in terms of both efficiency and effectiveness.
Using Excel’s Built-In Functions

As you saw in the previous chapter, a function is a predefined formula for performing a standard calculation. Excel includes several hundred built-in functions that you can simply insert in a cell and provide with the data they need to deliver the answer. Functions save you from having to create complex formulas from scratch and from getting such formulas wrong, so when you need to perform a standard calculation, check whether Excel has a function for it. There’s no point in reinventing the wheel, especially if the result isn’t round.
Dynamic changes in the reflex exam of patients with sub-axial cervical stenosis

Abstract Though dynamic changes in the physical exam of patients being evaluated for cervical spine pathology have been reported, there is limited information on the prevalence and clinical features associated with reflex changes in a population undergoing surgical evaluation for cervical spine pathology. Fifty-one patients with at least grade 1 cervical stenosis on MRI underwent initial surgical evaluation for cervical spine pathology. All patients received complete neurologic examinations including dynamic reflex testing in three positions (neck neutral, extended, and flexed) by 2 spine surgeons. The average age was 58.7 years (range, 34–80), with 28 (55%) patients being male. Stenosis at the symptomatic levels was grade 1 in 18 patients (35%), grade 2 in 11 (21%), and grade 3 in 22 (43%). Twenty-one patients (41%) had a dynamic change in reflex exam. The most common change in reflex exam was seen in the Hoffman’s reflex with 14 patients (28%). Patients with grade 3 stenosis were more likely to have a static Hoffman’s reflex (64%) compared with grade 1 (17%) and grade 2 (18%) (p
Relation of Intake Rate to Length of Run in Surface Irrigation

Relationship between intake rate of soil and length of run in surface irrigation with regard to amount of water lost below root zone through deep percolation; nomograph is included from which percentage of loss by deep percolation can be estimated for soils having different intake characteristics.
Mallomonas skogstadii sp. nov. and M. bakeri sp. nov.: Two New Fossil Species from the Middle Eocene Representing Extinct Members of the Section Heterospinae?

Two new fossil species of the synurophyte genus Mallomonas, M. skogstadii and M. bakeri, are described from Giraffe Pipe, an Eocene locality situated near the Arctic Circle in northern Canada. Scales of both new species share a suite of characters, including an oval-shaped rib encircling approximately half of the base plate and most of the dome, a series of thick ribs on the posterior flange, but lacking on the shield, a thin posterior rim, and a flat and shallow dome. In addition, both species possess two types of scales, body scales and apical scales. Apical scales of M. bakeri form a unique forward–projecting dome, and those of M. skogstadii are significantly different in shape than the body scales. Scales of M. skogstadii are significantly larger and have a different base plate pore pattern than those of M. bakeri, and remains of both taxa were uncovered in strata deposited hundreds of years apart. Based on comparison made with modern species, M. bakeri, and to a lesser extent M. skogstadii, are placed into, and likely represent basal representatives of section Heterospinae. The floras associated with each species reflect acidic environments, probably high in dissolved humic content.
Chapter 7 – Triangle Test

This chapter discusses the triangle test methodology, its setup, and practical usages. This test, considered as one of the most basic discrimination tests, is probably the most used methodology in the industry. Most fast-moving consumer good companies have used it as the standard methodology for decades to discriminate or ascertain similarity between products. The test can be used for different products ranging from food and drink to personal care, household, fabrics, etc. Good practices are provided to avoid any misuse of the methodology. Guidance is given in terms of products choice and preparation and in terms of information and instructions given to assessors to avoid bias. Directions are also given in the choice of the type of assessors and their numbers. Examples and references are provided to analyze and interpret the results.
X-ray sources from laser-plasma acceleration on picosecond, kilojoule-class lasers (Conference Presentation)

Plasma-based particle accelerators are now able to provide the scientific community with novel light sources. Their applications span many disciplines, including high energy density sciences, where they can be used as probes to explore the physics of dense plasmas and warm dense matter. The development and improvement of these light sources continues to be of great interest for the plasma physics community. This talk will present their experimental and theoretical characterization in a regime where little is known about their properties. In Self-modulated laser wakefield acceleration (SMLWFA), electrons are accelerated in a plasma wave driven by a long laser pulse broken up into a train of short pulses, each of these having a width on the order of a plasma period. Our recent experimental and theoretical work shows that we can use three mechanisms to produce high energy x-rays and gamma-rays from SMLWFA: Betatron motion of electrons, Bremsstrahlung, and inverse Compton scattering. A series of experiments at the LLNL Jupiter Laser Facility, using the 1 ps 150 J Titan laser, have demonstrated low divergence electron beams with energies up to more than 300 MeV and 10’s nCs of charge, and betatron x-rays with critical energies up to 20 keV. These experiments have led to important advances in understanding the details of the x-ray generating mechanisms and some of the most detailed characterization of the associated x-ray emission. New experiments have demonstrated using Compton scattering and Bremsstrahlung to generate >100 keV x-rays. This study presents the results of several highly successful experiments and associated theory and provides important understanding of these three sources. This work is an important step toward their development on large-scale international laser facilities, and also opens the prospect of using them for applications.
Scalable Performance Prediction of Codes with Memory Hierarchy and Pipelines

We present the Analytical Memory Model with Pipelines (AMMP) of the Performance Prediction Toolkit (PPT). PPT-AMMP takes high-level source code and hardware architecture parameters as input, predicts runtime of that code on the target hardware platform, which is defined in the input parameters. PPT-AMMP transforms the code to an (architecture-independent) intermediate representation, then (i) analyzes the basic block structure of the code, (ii) processes architecture-independent virtual memory access patterns that it uses to build memory reuse distance distribution models for each basic block, (iii) runs detailed basic-block level simulations to determine hardware pipeline usage. Further, PPT-AMMP uses machine learning and regression techniques to build the prediction models based on small instances of the input code, then integrates into a higher-order discrete-event simulation model of PPT running on Simian PDES engine. We validate PPT-AMMP on four standard computational physics benchmarks, finally present a use case of hardware parameter sensitivity analysis to identify bottleneck hardware resources on different code inputs.
Examination of Polypharmacy Trajectories Among HIV-Positive and HIV-Negative Men in an Ongoing Longitudinal Cohort from 2004 to 2016.

Abstract Polypharmacy is the concurrent use of five or more medications. We used group-based trajectory analysis to identify groups of non-HIV medication polypharmacy and investigate associated ris...
1295-P: Newly Diagnosed Pediatric Patients with Type 1 Diabetes Show Steady Decline in Glucose Time-in-Range (TIR) over 1 Year: Pilot Study

Optimal glycemic control is associated with improved T1D outcomes. However, in the U.S. over the last decade, glycemic control has worsened. We aimed to monitor glucose time-in-range (TIR) in the first year after diagnosis in pediatric T1D to identify the time when glucose control worsens. Newly diagnosed patients (N=67) with T1D were commenced on continuous glucose monitoring (CGM). Data was uploaded to Dexcom Clarity and analyzed retrospectively. Sample size differences at each time period vary due to patient enrollment start dates. All data was analyzed by mixed model and Tukey’s multiple comparison test. In 67 children (mean age 10±5 yrs, A1c at onset 12.1±1.9%) glucose TIR decreased from 64±21% to 55±18% at 10±9 days to 361±23 days post-diagnosis (P=0.03, Table). Mean glucose increased from 146±28 mg/dL at nadir to 172±29 mg/dL at 361±23 days post-diagnosis (P=0.001). CGM wear time also increased from 83±20% to 95±9% at 10±9 days to 361±23 days post-diagnosis (P=0.04). Time spent Disclosure D. Zaharieva: Speaker’s Bureau; Self; Ascensia Diabetes Care, Insulet Corporation, Medtronic. P. Prahalad: None. A. Addala: None. D. Scheinker: None. M. Desai: None. K.K. Hood: Research Support; Self; Dexcom, Inc. Speaker’s Bureau; Self; LifeScan, Inc., MedIQ. B. Leverenz: None. D.M. Maahs: Advisory Panel; Self; Eli Lilly and Company, Insulet Corporation, Medtronic, Novo Nordisk A/S. Consultant; Self; Abbott, Sanofi. Research Support; Self; Bigfoot Biomedical, Dexcom, Inc., Roche Diabetes Care, Tandem Diabetes Care.
Policing in the Eye of the Storm

In the wake of Hurricane Harvey, a series of focus groups were held with local law enforcement agencies in Southeast Texas to discuss the implementation of their emergency plans and challenges faced. The area suffered up to 60 in. of rain and flooding within three days. Their comments became prophetic when Tropical Storm Imelda swept through the area two years later dumping 42 in. of rain within a similar time frame. The purpose of this study is to present the lessons learned from a law enforcement perspective. A thematic qualitative design was used to identify key factors. Focus groups with the major law enforcement and local governmental officials in the Golden Triangle area of Southeast Texas revealed that prior existing relationships with other government entities, nonprofit organizations, and private industry are essential to address the challenges of coordination and system barriers that occur in the initial stages of response in the eye of the storm.
A Dual-Band Rectifying Antenna Design for RF Energy Harvesting

A novel dual-band rectifying antenna (also termed rectenna) is designed to harvest ambient energy at WIFI frequencies. The proposed rectenna consists of a Coplanar Waveguide (CPW) Folded-Slot (FS) antenna, a two-stages matching network, a half-wave rectifier circuit, and a resistive load. The CPW FS antenna is designed and demonstrated to resonate at both 2.4 and 5.2 GHz at a compact size of 55mm×30mm with a measured Return Loss (RL) higher than 20dB at each resonance, respectively. Harmonic Balance (HB) simulation is then performed to sweep input power levels and load resistance values to achieve the highest RF-DC conversion efficiency and corresponding output DC voltages. Expected RF-DC conversion efficiency and output DC voltage level at first resonance are 63.38% and 1.4V at an input power of 13 dBm and a load of 150 Ω. At the secondary resonance, the maximum conversion efficiency and output voltage can reach up to 65.4% and 1.53V at input power of 13 dBm and load of 150 Ω.
Hospital treatment of persons found not guilty by reason of insanity

After being found not guilty by reason of insanity (NGRI), individuals are typically admitted to a secure forensic hospital for evaluation and treatment. This patient population can pose a challenge to clinicians in the hospital setting due to significant violence risk, complex psychiatric presentations, and scrutiny from oversight boards and the public. This article reviews the scientific literature around several key aspects of hospital-based treatment of insanity acquittees, including the management of inpatient aggression, the provision of specific treatments to acquittees, the assessment of violence risk and readiness for release, and the process of community transition. The authors conclude that the existing literature is heavily weighted toward the study of risk assessment and recidivism, with relatively little attention paid to the study of therapeutic modalities and recovery-oriented care in this population.