cssi/SciSciGPT-SciSciNet huggingface dataset:
Numerical simulation of non‐isothermal SMC (sheet molding compound) molding

Design of molding tools and molding cycles for sheet molding compounds (SMC) is often expensive and time consuming. Computer simulation of the compression molding process is a desirable approach for reducing actual experimental runs. The focus of this work is to develop a computer model that can simulate the most important features of SMC compression molding, including material flow, heat transfer, and curing. A control volume/finite element approach was used to obtain the pressure and velocity fields and to compute the flow progression during compression mold filling. The energy equation and a kinetic model were solved simultaneously for the temperature and conversion profiles differential scanning calorimetry (DSC) was used to experimentally measure the polymer zation kinetics. A rheometrics dynamic analyzer (RDA) was used to measure the rheological changes of the compound. A series of molding experiments was conducted to record the flow front location and material temperature. The results were compared to simulated flow front and temperature profiles.
Synovial cyst of the cervical spine: case report and review of the literature.

A 42-year-old woman was in good health until 2 years before admission. when she began to have right-sided neck pain radiating to the right shoulder. This progressed in severity for 18 months. at which time she began having episodes of spontaneous torticollis accompanied by muscle spasms in her neck and right shoulder. In addition. she experienced infrequent episodes of tingling in her right arm. especially when her head was tumed to the left. against the spastic muscles. There were no complaints of motor problems in the extremities. and no history of trauma. On physical examination. the patient's head was turned to the right. with contraction of the sternocleidomastoid muscle and elevation of the right shoulder. The cranial nerves were intact. and there were no sensory or motor abnormalities. Laboratory studies were normal. including sedimentation rate. rheumatoid factor. and antinuclear antibody. Clinical diagnosis was neurogenic torticollis. Radiographs of the cervical spine revealed grade-I spondylolisthesis of C4 on C5. with mild disk space narrowing. There was a hypertrophic spur seen on the posterior aspect of the superior end plate of C5. and slight irregularity of the superior aspect of the C5 facet (Fig. 1). Pleuridirectional tomography disclosed erosion of the inferior and superior facet margins on the right at C4-C5 (Figs. 2 and 3). The margins were slightly irregular. with bone erosion. and were accompanied by mild eburnation of the joint surface. The joint space itself appeared widened. probably due to effusion. CT with first-generation scanners . both with and without contrast. again demonstrated the facet erosion with no soft-tissue mass seen in the periarticular area. Myelography was not performed. At surgery. a soft-tissue mass was seen protruding between the laminae on the right at C4C5. Partial laminectomy of the inferior aspect of the C4 lamina revealed a cystic mass in the region of the facet joint itself. causing widening of the jOint space. The mass was easily dissected free of the C5 nerve root. which had been compressed by the cyst. Clear fluid was obtained from the cyst. Histologic examination revealed fibrous tissue walls with a lining of reactive synovial cells (Fig . 4).
Distressing adverse events after antidepressant switch in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial: influence of adverse events during initial treatment with citalopram on development of subsequent adverse events with an alternative antidepressant.

STUDY OBJECTIVE To determine whether distressing adverse events (DAEs) experienced during initial antidepressant treatment are associated with subsequent DAEs after switching to a second antidepressant. DESIGN Secondary analysis of data from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial. SETTING Primary care and psychiatric care facilities. PATIENTS A total of 727 outpatients aged 18-75 years with nonpsychotic major depressive disorder who failed first-step therapy with citalopram and were switched to second-step monotherapy with an alternative antidepressant. MEASUREMENTS AND MAIN RESULTS In the STAR*D trial, patient-reported DAEs were entered into the Patient-Rated Inventory of Side Effects (PRISE). In this secondary analysis, data from PRISE were used to determine the incidence of DAEs during first-step treatment with citalopram and second-step treatment with sustained-release bupropion, sertraline, or extended-release venlafaxine. Regression models were used to compare the risk of adverse events during second-step treatment between those who reported similar adverse events during first-step treatment and those who did not, while controlling for potential confounders. Of the 727 patients analyzed, DAEs were reported by 514 patients (70.7%) during first-step treatment and 626 (86.1%) during second-step treatment; no significant differences were observed among the three second-step treatment groups. Overall, patients reporting DAEs during first-step treatment were more likely to report DAEs during second-step treatment (risk ratio [RR] 1.11, 95% confidence interval [CI] 1.03-1.20). After controlling for confounders, patients were significantly more likely to report DAEs specific to a body function or organ system, such as those involving the genitourinary system (RR 3.39, 95% CI 2.41-4.78) or sexual functioning (RR 2.75, 95% CI 2.29-3.29), if the patients had reported similar events during initial treatment. CONCLUSION Patients who experienced DAEs with initial antidepressant treatment were likely to report similar adverse events after switching to an alternative antidepressant, even when subsequent treatment is from a different class of antidepressants.
Fairness Opinions in Mergers and Acquisitions

When evaluating a merger or acquisition proposal, boards frequently seek fairness opinions from their financial advisors. This fairness opinion ratifies the consideration being paid or received as "fair from a financial point of view" to shareholders. This chapter (Chapter 26 in "The Art of Capital Restructuring: Creating Shareholder Value through Mergers and Acquisitions", Baker and Kiymaz (eds.),Wiley 2011) describes how a Delaware Supreme Court ruling and Delaware corporate law combined to institutionalize fairness opinions and how the form and content of a fairness opinion results from concerns over limiting the liability associated with delivering the opinion. It then surveys the limited finance literature that examines whether fairness opinions provide value to shareholders or serve the interests of the board and management at the expense of shareholders. It also highlights the difficulties associated with conducting such empirical tests because of the way fairness opinions are sought and provided. It concludes with some conjectures about the potential value of fairness opinions, and raises questions for future research.
Mutational Analysis of the Properties of Caveolin-1 A NOVEL ROLE FOR THE C-TERMINAL DOMAIN IN MEDIATING HOMO-TYPIC CAVEOLIN-CAVEOLIN INTERACTIONS

Caveolin is a principal structural component of caveolae membranes in vivo Recently, a family of caveolin-related proteins has been identified; caveolin has been retermed caveolin-1. Caveolin family members share three characteristic properties: (i) detergent insolubility at low temperatures; (ii) self-oligomerization; and (iii) incorporation into low density Triton-insoluble fractions enriched in caveolae membranes. Here, we have used a deletion mutagenesis approach as a first step toward understanding which regions of caveolin-1 contribute to its unusual properties. Two caveolin-1 deletion mutants were created that lack either the C-terminal domain (Cav-1ΔC) or the N-terminal domain (Cav-1ΔN); these mutants were compared with the behavior of full-length caveolin-1 (Cav-1FL) expressed in parallel. Our results show that the N-terminal domain and membrane spanning segment are sufficient to form high molecular mass oligomers of caveolin-1. However, a complete caveolin-1 molecule is required for conveying detergent insolubility and incorporation into low density Triton-insoluble complexes. These data indicate that homo-oligomerization and an intact transmembrane are not sufficient to confer detergent insolubility, suggesting an unknown role for the C-terminal domain in this process. To better understand the role of the C-terminal domain, this region of caveolin-1 (residues 135-178) was expressed as a glutathione S-transferase fusion protein in Escherichia coli Purified recombinant glutathione S-transferase-C-Cav-1 was found to stably interact with full-length caveolin-1 but not with the two caveolin-1 deletion mutants. These results suggest that the C-terminal domain interacts with both the N-terminal and C-terminal domains of an adjacent caveolin-1 homo-oligomer. This appears to be a specific homo-typic interaction, because the C-terminal domain of caveolin-1 failed to interact with full-length forms of caveolin-2 and caveolin-3. Homo-typic interaction of the C-terminal domain with an adjacent homo-oligomer could provide a mechanism for clustering caveolin-1 homo-oligomers while excluding other caveolin family members. This type of lateral segregation event could promote caveolae membrane formation and contribute to the detergent insolubility of caveolins-1, −2, and −3.
The design and testing of a 600000 transistor standard cell ASIC for the Raycasting Engine

Describes the design and implementation of a 600000 transistor ASIC designed using standard cells, to be used in the next generation of the Ray-casting Machine. The authors present a new redundancy scheme with testing methodology that allows one to build, test, and reconfigure for increased yield a large array of identical processors. >
Unraveling hypertension: epigenomics comes of age.

Shifting paradigms in hypertension research Early recognition of a significant familial aggregation of high blood pressure [2] held promises that gene discovery would offer significant insights into disease pathophysiology and open avenues for the development of novel therapeutic modalities. In the past decade, genome-wide linkage strategies have successfully identified genes for several rare forms of hypertension, in each of which a single gene imparts large effects on blood pressure in affected individuals [3]. However, the population-wide attributable risk for hypertension of each of these rare gene variants is minimal, and the contribution of common variants of these genes to susceptibility to high blood pressure remains largely unverified. Despite considerable efforts [4], application of linkage mapping strategies to the common form(s) of hypertension has failed to yield significant progress in identifying disease genes, indicating that genes of large effects are unlikely to underlie susceptibility to high blood pressure in the population-at-large. In an attempt to detect susceptibility genes of small-to-moderate effects, research efforts are now shifting toward linkage disequilibrium strategies that assess the association of disease phenotypes with single nucleotide polymorphisms (SNPs) distributed over the whole genome. These studies are made possible by advances in the identification and characterization of patterns of sequence variation in human populations, coupled with the development of large-scale cost-effective genotyping technologies. Yet, limitations of these ‘genotype-centric’ strategies are predicted by the growing recognition that susceptibility to common chronic diseases such as hypertension, is shaped by the dynamic and adaptive responses of physiological and regulatory networks – at the levels of individual cells, tissues, organs or whole organisms – to genetic variation and variation in environmental exposures indexed over time and space [5,6]. Hence, comprehensive research approaches that efficiently integrate genomic and epigenomic information are required to fully understand susceptibility to disease such as hypertension.
Basal cell carcinoma of the nail unit

We report a case of a 70-year-old white male with a basal cell carcinoma of the left thumb nail unit. Excision of the tumor via Mohs micrographic surgery was completed in 2 stages. The defect was repaired with a full thickness skin graft. Five months later the nail unit healed without complications. Prior to this report, 21 cases of basal cell carcinoma have been reported in the world literature. This case, as well as the prior reports, are reviewed with a focus on time to diagnosis, location, excisional technique, and method of repair.
A random effect autologistic regression model with application to the characterization of multiple microstructure samples

ABSTRACTThe microstructure of a material can strongly influence its properties such as strength, hardness, wear resistance, etc., which in turn play an important role in the quality of products produced from these materials. Existing studies on a material's microstructure have mainly focused on the characteristics of a single microstructure sample and the variation between different microstructure samples is ignored. In this article, we propose a novel random effect autologistic regression model that can be used to characterize the variation in microstructures between different samples for two-phase materials that consist of two distinct parts with different chemical structures. The proposed model differs from the classic autologistic regression model in that we consider the unit-to-unit variability among the microstructure samples, which is characterized by the random effect parameters. To estimate the model parameters given a set of microstructure samples, we first derive a likelihood function, based on...
An urban intergenerational program for cancer control education.

Abstract Background. Recognizing the disparities in cancer morbidity and mortality that exist between African Americans and whites, an urban university and its neighborhood community undertook the development of an education program to transfer state‐of‐the‐art cancer prevention, detection, and treatment information from an academic medical center to community residents, including school‐age children. Methods. An intergenerational, multilevel intervention was developed to: 1) assess the health beliefs of the community, 2) identify, develop, and train an intergenerational group of community residents who would serve as health educators, and 3) promote behavioral change among the target population. Results. Ten community residents were trained as educators. Over the course of two years they conducted cancer education programs that reached 775 adults. During the same period, the school‐based educational intervention reached 264 seventh‐grade students. Conclusions. Implications for the design and implementati...
Circulating concentrations of estradiol, luteinizing hormone, and follicle-stimulating hormone during waves of ovarian follicular development in prepubertal cattle.

Objectives were to characterize changes in concentrations of LH, FSH, and estradiol-17b (estradiol) in blood and populations of ovarian follicles of prepubertal cattle during waves of follicular development and to evaluate interactions between day after follicular aspiration and month prepuberty for these variables. During each month (month prepuberty), ovarian follicles of prepubertal cattle were aspirated to induce synchronous emergence of a wave of follicular development (day after follicular aspiration). Characteristics of ovarian follicular development and concentrations of hormones in blood were evaluated during the synchronous wave of follicular growth. Multiple regression was used to estimate hormonal variables and evaluate interactions for variables between day after follicular aspiration and month prepuberty. There were no interactions between day after follicular aspiration and month prepuberty for numbers of follicles # 4o r. 5 mm or concentrations of LH, FSH, and estradiol. The pattern of change in these variables after follicular aspiration was, therefore, similar each month prepuberty. There were interactions between day after follicular aspiration and month prepuberty for frequency and amplitude of LH pulses and size of largest follicle. There were also endocrine changes that were related to follicular development after follicular aspiration throughout the peripubertal period.
Study of the Level Structure of Ni 60 from (p, p'γ) Angular Distributions

Measurements of ${\mathrm{Ni}}^{60}(p, {p}^{\ensuremath{'}}\ensuremath{\gamma})$ angular distributions have been made for incident proton energies of 5 to 7 MeV, using a 99.0% enriched ${\mathrm{Ni}}^{60}$ target 3.9 mg/${\mathrm{cm}}^{2}$ thick. The $\ensuremath{\gamma}$-ray spectra become quite complex at 7 MeV, with transitions from most of the ${\mathrm{Ni}}^{60}$ states up to 4-MeV excitation being present. The angular distributions remain essentially the same at various energies after correction for cascade feeding. The earlier tentative ${0}^{+}$ assignment for the 2.29-MeV level now appears to be correct, since the angular distribution of the 0.95-MeV $\ensuremath{\gamma}$ ray is isotropic (\ifmmode\pm\else\textpm\fi{}4%) and the ($p, {p}^{\ensuremath{'}}$) cross section is in good agreement with Hauser-Feshbach theory. From its observed angular distribution, a 0.47-MeV cascade (2.63\ensuremath{\rightarrow}2.16 MeV) has been identified as a ${3}^{+}(M1, E2){2}^{+}$ transition essentially pure $E2$ in character. The angular distribution of the 1.79-MeV cascade from the 3.12-MeV level agrees with the prediction for a ${2}^{+}(M1, E2){2}^{+}$ transition with a mixing ratio of $\ensuremath{\delta}=0.24\ifmmode\pm\else\textpm\fi{}0.06$, in accord with a previous determination from the decay of ${\mathrm{Cu}}^{60}$. The present work indicates the following level scheme for ${\mathrm{Ni}}^{60}$: 1.33(${2}^{+}$), 2.16(${2}^{+}$), 2.29(${0}^{+}$), 2.50(${4}^{+}$), 2.63(${3}^{+}$), and 3.12(${2}^{+}$); 3.19(1) and 3.39(3 or 2) MeV.
A Reactive Bearing Angle Only Obstacle Avoidance Technique for Unmanned Ground Vehicles

In this paper, we present a reactive, vision based obstacle avoidance technique for Unmanned Ground Vehicles (UGVs) navigating in an indoor environment without Global Positioning System (GPS) signals. The proposed technique enables UGVs to maneuver using only visual electro-optic sensors. The proposed work is unique in that, to the best of our knowledge, there was no other bearing angle only obstacle avoidance technique for ground vehicles reported in the literature. A Lyapunov-based sliding mode controller is used to maintain the bearing angle of the UGV from obstacles, using a real-time image processing method. The proposed technique is implemented and tested with a Pioneer robot in an indoor environment, and the results demonstrate its effectiveness.
Format and Symbols in TV Coverage of Terrorism in the United States and Great Britain

A conceptual scheme for understanding how TV news formats shape reports broadcast in the United States and the United Kingdom is examined in this explanatory, comparative study of TV news coverage of a terrorist incident in London's Hyde Park in 1982. While ideological positions clearly flow from most news reports, the analysis suggests that news practices and perspectives also contribute to the visual and thematic emphasis of reports. News formats of the event type associated with regular evening newcasts in both countries focused on visuals of the aftermath and tactics of terrorism, while topic type formats associated with interviews and documentary presentations included materials about purposes, goals, and rationale. These variations in format produced consistent differences in message content in both countries, suggesting that an organizational media logic is relevant for understanding information control about terrorism and other events. Implications are noted for theoretic understanding about ideology and social control. In particular, future research attention is directed to regulation and control of news formats, and the implications for a mass audience, leadership styles, and international affairs.
Trend of Health Management for Radiation Workers in Liangshan Prefecture during 27 Years

[Objective]To understand the history and current situation of health management for radiation workers in Liangshan Yi Autonomous Prefecture.[Methods]The information of radiological health work in Liangshan Prefecture from 1979 to 2008 were collected and reorganized.Retrospective investigation was adopted to perform statistical analysis.[Results]Occupational health examination rate of radiation workers in Liangshan Prefecture had increased from 67.01% in 1986 to 73.45%-95.03% in recent years.The rate of individual dose monitoring had increased from 18.27% in 1986 to 73.45%-95.03% in recent years.[Conclusion]With the development of radiation health,health management and health care of radiation workers in Liangshan Prefecture has been further strengthened and standardized gradually during 27 years.Occupational health examination rate of radiation workers shows upward trend.The health management of radiation workers has already covered a full range of occupational health surveillance such as the occupational health inspection,education(radiological protection knowledge,training of radiological health laws and regulations) and individual dose monitoring as well as establishment of occupational health files.However,the implementation status of health examination on workers being employed and being unemployed has been poor,and should be further strengthened.
Förster resonance energy transfer (FRET) microscopy for monitoring biomolecular interactions.

Forster or Fluorescence resonance energy transfer (FRET) can be used to detect protein-protein interactions. When combined with microscopy, FRET has high temporal and spatial resolution, allowing the interaction dynamics of proteins within specific subcellular compartments to be detected in cells. FRET microscopy has become a powerful technique to assay the direct binding interaction of two proteins in vivo. Here, we describe a sensitized emission method to determine the presence and dynamics of protein-protein interactions in living cells.
Confidence Statements about the Time Range over which Survival Curves Differ

SUMMARY Statistical tests can indicate that two groups have different survival experiences without the associated survival curves being stochastically ordered. Often the two survival curves are similar at early times, even though eventually one curve might dominate the other. This paper addresses the problem of making confidence statements about the range of time over which survival curves differ. In particular, the data are subjected to right censoring and we focus on estimating an upper confidence bound for the earliest time at which the survival curves diverge and remain different.
Internationalization and longevity of small- and medium-sized software firms

This study empirically analyzes the relationship between the internationalization of small- and medium-sized software firms (SMSFs) and their longevity. Analysis on data from US-based SMSFs shows that even though the size of internationalization does not affect longevity, the volatility of internationalization positively influences the longevity of SMSFs. This study also shows that the longevity of SMSFs has negative relationship with the number of high-risk foreign countries of operation; short-lived SMSFs have more assets compared with long-lived SMSFs and improve longevity through mergers and acquisitions.
Redesigning pictographs for patients with low health literacy and establishing preliminary steps for delivery via smart phones

Background: Pictographs (or pictograms) have been widely utilized to convey medication related messages and to address nonadherence among patients with low health literacy. Yet, patients do not always interpret the intended messages on commonly used pictographs correctly and there are questions how they may be delivered on mobile devices.Objective: Our objectives are to refine a set of pictographs to use as medication reminders and to establish preliminary steps for delivery via smart phones.Methods: Card sorting was used to identify existing pictographs that focus group members found “not easy” to understand. Participants then explored improvements to these pictographs while iterations were sketched in real-time by a graphic artist. Feedback was also solicited on how selected pictographs might be delivered via smart phones in a sequential reminder message. The study was conducted at a community learning center that provides literacy services to underserved populations in Seattle, WA. Participants aged 18 years and older who met the criteria for low health literacy using S-TOFHLA were recruited.Results: Among the 45 participants screened for health literacy, 29 were eligible and consented to participate. Across four focus group sessions, participants examined 91 commonly used pictographs, 20 of these were ultimately refined to improve comprehensibility using participatory design approaches. All participants in the fifth focus group owned and used cell phones and provided feedback on preferred sequencing of pictographs to represent medication messages.Conclusion: Low literacy adults found a substantial number of common medication label pictographs difficult to understand. Participative design processes helped generate new pictographs, as well as feedback on the sequencing of messages on cell phones, that may be evaluated in future research.
Growth and Survival of Campylobacter fetus subsp. jejuni as a Function of Temperature and pH

The objective of this study was to determine what effect temperature and pH have on the ability of Campylobacter fetus subsp. jejuni to grow and survive. None of three strains of C. fetus subsp. jejuni could grow at 30 C and below or at 47 C and above. The optimum temperature for growth was in the range of 42 to 45 C. Only one of three strains, FRI-CF8, could grow at pH 4.9 and none could grow at pH 4.7. The optimum pH for growth was in the range of 6.5 to 7.5; however, all strains grew well at pH 5.5 to 8.0. Rate of cell death at pH 3.0 to 4.5 was temperature-dependent. At comparable pH, cells of C. fetus subsp. jejuni died most rapidly at 42 C, less rapidly at 25 C and at the slowest rate at 4 C. For example, at pH 4.5, a 3 log10 decrease of cells occurred within 8 h when incubated at 42 C but took 4 days when incubated at 4 C. At 25 C and pH 4.5, cells were inactivated at an intermediate rate. Rates of thermal inactivation of five strains of C. fetus subsp. jejuni were determined at 48, 50, 53, and 55 C in a skim milk heating menstruum. At 48 C, D-values ranged from 7.2 to 12.8 min while at 55 C they ranged from 0.74 to 1.00 min. The times and temperatures used to pasteurize milk should be sufficient to free milk of even unusually large numbers of viable cells of C. fetus subsp. jejuni.
Instant gratification: temporal discounting and self-employment

Differences in temporal discounting could separate self-employed individuals from employees working for wages. Drawing on a sample of 13,198 individuals, from the 2012–2013 cross-sectional STEP Skills Measurement Survey, we find that higher temporal discounting is more positively associated with the likelihood of self-employment. We further find that younger individuals with higher temporal discounting are more likely to engage in self-employment. The association of lower socioeconomic status at a young age or those who experienced economic shocks at a young age with the likelihood of self-employment is only significant when interaction effects of temporal discounting and age are present in the model. Risk seeking is not associated with the likelihood of engagement in self-employment under higher discounting. These findings have implications for the self-employment literature as well as the literature on behavioral decision making.
Internet-based cognitive behavior therapy for major depressive disorder: A randomized controlled trial

Background Prior research has shown that the Sadness Program, a technician-assisted Internet-based cognitive behavioral therapy (iCBT) intervention developed in Australia, is effective for treating major depressive disorder (MDD). The current study aimed to expand this work by adapting the protocol for an American population and testing the Sadness Program with an attention control group. Methods In this parallel-group, randomized controlled trial, adult MDD participants (18–45 years) were randomized to a 10-week period of iCBT (n = 37) or monitored attention control (MAC; n = 40). Participants in the iCBT group completed six online therapy lessons, which included access to content summaries and homework assignments. During the 10-week trial, iCBT and MAC participants logged into the web-based system six times to complete self-report symptom scales, and a nonclinician technician contacted participants weekly to provide encouragement and support. The primary outcome was the Hamilton Rating Scale for Depression (HRSD), and the secondary outcomes were the Patient Health Questionnaire-9 and Kessler-10. Results Intent-to-treat analyses revealed significantly greater reductions in depressive symptoms in iCBT compared with MAC participants, using both the self-report measures and the clinician-rated HRSD (d = −0.80). Importantly, iCBT participants also showed significantly higher rates of clinical response and remission. Exploratory analyses did not support illness severity as a moderator of treatment outcome. Conclusions The Sadness Program led to significant reductions in depression and distress symptoms. With its potential to be delivered in a scalable, cost-efficient manner, iCBT is a promising strategy to enhance access to effective care.
Selected Commensals Mediate GvHD Via MyD88-Dependent Signaling in Non-Hematopoietic Cells.

Abstract 3005 Graft-versus-host disease (GVHD) primarily affects the epithelial compartments of skin, liver, and gut and is thought to display tissue tropism for two main reasons: the conditioning regimen can selectively damage these epithelial cell compartments due to rapid cell turnover; and these epithelial organs have high exposure to host commensals and their products that promote tissue-specific inflammation. To understand how commensals mediate GVHD, we first tested the hypothesis that the disruption of the MyD88 signaling pathway, which is critical for host-microbe interaction, would alter GVHD outcomes. We created bone marrow chimeras that received a second allogeneic bone marrow transplant (BMT) and showed that MyD88 deficiency in recipient hematopoietic cells reduced BMT mortality, while deficiency in the non-hematopoietic cells (NHC) increased BMT mortality (p Disclosures: No relevant conflicts of interest to declare.
Ovotestis in Adolescence: 2 Case Reports

We present 2 patients found to have ovotesticular disorder of sexual development (otDSD) in late adolescence. Two 15-year-old phenotypically male patients presented to a large pediatric hospital with different complaints: 1 with concern for testicular rupture after a straddle injury; 1 with gynecomastia. Further workup, including imaging and laboratory tests, was performed before surgical exploration. The first patient had unilateral ovotestis, contralateral testis, and SRY-negative 46,XX karyotype. The second patient with gynecomastia had unilateral ovotestis with hemi-uterus and fallopian tube, contralateral ovarian tissue, and 46,XX/47,XXY Klinefelter mosaic karyotype. Although rare, phenotypically normal male patients may present later with ovotesticular disorder of sexual development.
Failure Mechanisms and Methods to Estimate Material Resistance to Failure

This chapter discusses the most common forms of failure in asphalt mixtures, i.e., rutting, fatigue cracking, transverse cracking, moisture-induced damage, bleeding or flushing, and the influence of aging on these distresses. The chapter discusses the mechanism of failure for each one of these distresses. Two different approaches to measure the resistance of mixtures to any of these distresses are discussed: (i) the measurement of empirical performance indicators, and (ii) the measurement of fundamental material properties that can be combined with numerical models to measure the performance of the mixture. Examples based on each of the above two approaches for each distress type (rutting, fatigue cracking, low-temperature cracking, and moisture damage) are discussed. These discussions also provide a context for the mechanistic tools that are discussed in Part 2 of this book.
Project Feedback Loops: Visualizing Collection Evaluation Decisions

In 2016, a collection assessment project evaluated print serials and book collections at Johns Hopkins University in preparation for an upcoming renovation of the Eisenhower Library. Project metric...
Serial Poisoning: Actualizations of the “Yellow Peril” in 1960s Fu Manchu Films

This chapter argues that poison does not only appear to be the signature weapon of Fu Manchu, but that the characteristics of poison apply to the master villain himself. The ‘logic of spread’ (Mayer 2013) inherent to the serial figure is linked to the danger of racialized contamination through expansion, evoked by the term “yellow peril.” Focusing on the 1960s Fu Manchu film series, primarily produced for the West-German market, the essay traces the emergence of the trope to German Imperialism and analyses the series’ historical displacements. It shows that in the films, the poison motif rather reflexively points to the serial poisoning by Fu Manchu’s cinematic returns, which can be understood as an attempt to immunize against his imagined ‘toxic’ nature. This becomes especially apparent when, in the last entry The Castle of Fu Manchu (1969, D. Jess Franco), the poisoning leaves the narrative and spreads onto the screen.
Architect of Quality: The Autobiography of Dr. Joseph M. Juran

(2004). Architect of Quality: The Autobiography of Dr. Joseph M. Juran. Quality Management Journal: Vol. 11, No. 2, pp. 53-53.
Acoustic Characterization of Pulse Detonation Combustors

The Paper deals with the investigation of the effect of multiple facets of pulse detonation combustors on its acoustic signature. First, the acoustic signature is characterized in both the near- an...
Sanism and the Law

Sanism, irrational prejudice against people with mental illness including erroneous and stereotypical beliefs, perverts legal proceedings involving the mentally ill.
Archaebacteria and Cellular Origins: An Overview

Summary Archaebacteria are a group of organisms distinct from all others at the highest level. They are no more related to other bacteria, i.e., the true bacteria (eubacteria) than they are to eucaryotic cells. Archaebacteria, eubacteria and (some aspect of) the eucaryotic cell each represent separate primary lines of descent. The archaebacteria comprise a small but diverse collection of phenotypes. While they have certain unique common phenotypic characteristics, it would have been difficult to group them convincingly on the basis of these. What was needed (and what is needed in all reliable and convincing phylogenetic measurement) is a genotypic neutral measure of genealogical relationships. Macromolecules are chronometric, in that other things being constant, changes in their sequences mark time (in a stochastic, not a metronomic way). Comparative sequence analysis is therefore a powerful measure of genealogical relationships. Using such (neutral) genotypic measures, phylogenetic ordering at the higher levels can be reliably determined — and archaebacteria can be recognized for the primary kingdom that they are. Although it is too early to generalize with certainty, it seems that the archaebacteria differ from the other two major groups in significant details of most, if not all, molecular processes. [This is the same way in which “procaryotes” were known to differ from eucaryotes at the mloecular level.] It does not seem reasonable intuitively that this extent of difference among the three primary kingdoms can be accounted for by one of the phenotypes undergoing an extensive evolution to become the others. Rather, it seems that all lines have shared a common ancestor that possessed a more rudimentary, less detailed, phenotype, and so each has evolved separately the details in which they differ. The universal common ancestor should be called a progenote; it is an organism still in the throes of evolving the link between genotype and phenotype. The important question is why there is a universal, unique ancestor. The existence of archaebacteria provides a new and powerful perspective on the origin of the eucaryotic cell. As a result, our concept of eucaryotic origins will undergo revision. The conventional endosymbiotic model for eucaryotic origins is no longer a sufficient explanation. The main characteristics of the eucaryotic cell — those that distinguish it at the molecular level — were evolved long before the endosymbioses that led to he mitochon- drion and the chloroplast. The nature of the eucaryotic cell is perhaps related to the nature of the ancestral progenote. The evolutionary questions and answers offered by archaebacteria should go far to rekindle the biologist's flagging interest in evolutionary matters, and hopefully divert biology to some extent from its present course of technological adventurism.
The Electric Potential

We have just seen how a force motivates the idea of an electric field (the electric force per unit test charge).
The Common LISP object system: an example of integrating programming paradigms

Publisher Summary A programming paradigm is a supported style of programming with significant advantages for a domain of problems. Many programming paradigms have been added on top of LISP, but few have been tightly integrated. Common LISP Object System (CLOS) is a model of a good integration. CLOS blends the object-oriented programming paradigm smoothly and tightly with the usual procedure-oriented paradigm of LISP. Functions and methods are combined in a more general abstraction. Message passing is invoked via normal LISP function call and methods are viewed as partial descriptions of procedures. LISP data types are integrated with object classes. With these integrations, it is easy to incrementally move a program between the procedure and object-oriented styles. By integrating classes with the LISP type system and using a syntax for method invocation that is identical to the LISP function call, CLOS makes possible a smooth and incremental transition from using only the functional paradigm for user code to using the object paradigm. As a portable system implemented in a widely available base, it allows users the choice of hardware and environments. It allows them a road to the future.
Emerging Issues in Victim Assistance

Follow this and additional works at: http://digitalcommons.pepperdine.edu/plr Part of the Civil Rights and Discrimination Commons, Criminal Law Commons, Criminal Procedure Commons, Law and Society Commons, Law Enforcement and Corrections Commons, Legal History, Theory and Process Commons, Legislation Commons, Organizations Commons, Public Law and Legal Theory Commons, Remedies Commons, and the State and Local Government Law Commons
Family Matters: How Family Influenced My Career

My family emigrated from Korea, and I was born and raised in the Bronx. I was taught to value education, and my parents worked several jobs just so my brother and I could go to good schools. I loved math and science all throughout my life and got to experience research during my high school career. My love was fostered by my teachers, and, while I never considered an academic scientist as a career, it was my teachers and mentors who led me on my path.
Changes in stair ascent biomechanics two to eight years after ACL reconstruction are associated with patient-reported outcomes.

Abstract Background Anterior cruciate ligament (ACL) injury is often followed by quadriceps deficits that are apparent with gait analysis. The deficit frequently remains after ACL reconstruction (ACLR). As such, evaluation of ACLR patients could be enhanced by a simple method to detect quadriceps deficits. Analyzing forward trunk flexion during stair ascent has been suggested as an assessment of quadriceps function that can be visualized with relatively simple instrumentation. Aim The purpose of this study was to determine if trunk flexion angle (TFA) during stair ascent is associated with quadriceps function (as measured by the peak knee flexion moment (KFM)) at 2 and 8 years post-ACLR and if changes are associated with patient-reported outcomes (PRO). Methods Fourteen subjects with unilateral primary ACLR performed three stair-ascending trials at two-time periods: 2 years (baseline) and 8 years (follow-up) post-ACLR. Paired Student t-tests determined differences in KFM and TFA. Associations between KFM, TFA, and PRO were determined through Pearson correlations. Results Peak KFM during stair ascent significantly increased from baseline to follow-up (p = 0.01). Though there was no significant difference in TFA (p = 0.84) compared to baseline, 50% of subjects showed decreases in TFA. Further, subjects with reduced TFA during stair ascent at follow-up had significantly increased peak KFM (p = 0.029) and improvements in PRO (p = 0.001). Discussion The results suggest that TFA during stair ascent can provide a simple method to assess changes in quadriceps function and pain over time following ACLR. Further analysis is needed to draw conclusions between knee osteoarthritis development and increases in TFA.
Sweet baby Jesus, the band who must not be named, and friends U can’t trust: Disparaging, immoral and scandalous trademarks in the United States and the European Union

ABSTRACTThis article will compare the ways in which the European Union’s Office of Intellectual Property (EUIPO) and the US Patent and Trademark Office (PTO) have interpreted and applied their resp...
Simon, Robert. Understanding the Portuguese Poet Joaquim Pessoa, 1942-2007: A Study in Iberian Cultural Hybridity. Lewiston: Edwin Mellen Press, 2008.

In his book, Simon proceeds from several ambitious— although legitimate—premises. He claims that since the 1970s postmodernism has been one of the most defining (and unchanging) traits of the lyrical tradition of Portugal and Spain and, most interestingly, that both during the Portuguese and the Spanish dictatorships these postmodern characteristics constituted deconstructive and self-referential symptoms of subversive intentions behind apparently esoteric writings.
A Usability Study of Low-Cost Wireless Brain-Computer Interface for Cursor Control Using Online Linear Model

Computer cursor control using electroencephalogram (EEG) signals is a common and well-studied brain-computer interface (BCI). The emphasis of the literature has been primarily on evaluation of the objective measures of assistive BCIs such as accuracy of the neural decoder whereas the subjective measures such as user's satisfaction play an essential role for the overall success of a BCI. As far as we know, the BCI literature lacks a comprehensive evaluation of the usability of the mind-controlled computer cursor in terms of decoder efficiency (accuracy), user experience, and relevant confounding variables concerning the platform for the public use. To fill this gap, we conducted a 2-D EEG-based cursor control experiment among 28 healthy participants. The computer cursor velocity was controlled by the imagery of hand movement using a paradigm presented in the literature named imagined body kinematics with a low-cost wireless EEG headset. In this article, we evaluated the usability of the platform for different objective and subjective measures while we investigated the extent to which the training phase may influence the ultimate BCI outcome. We conducted pre- and post-BCI experiment interview questionnaires to evaluate the usability. Analyzing the questionnaires and the testing phase outcome shows a positive correlation between the individuals’ ability of visualization and their level of mental controllability of the cursor. Despite individual differences, analyzing training data shows the significance of electrooculogram on the predictability of the linear model. The results of this work may provide useful insights towards designing a personalized user-centered assistive BCI.
Patient-Level Factors Associated with Oncology Provider-Delivered Brief Tobacco Treatment Among Recently Diagnosed Cancer Patients.

Background:A cancer diagnosis is seen as a “teachable moment” for patients to consider changing their behavioral risk factors, such as smoking. It also offers an opportunity for oncology providers ...
Quantum dot multi-wavelength lasers for Tbit/s coherent communications and 5G wireless networks -INVITED

We will present the design, growth, fabrication, electronic control and packaging of the InAs/InP quantum dot (QD) multi-wavelength lasers (MWLs) developed by AEP of NRC in Canada. Their key technical specifications include L-I-V curves, optical and RF beating spectra, relative intensity noise (RIN), and optical phase noise of each individual wavelength channel, as well as timing jitter are investigated. Data bandwidth transmission capacity of 5.376 Tbit/s and 10.3 Tbit/s respectively in the PAM-4 and 16-QAM modulation formats are demonstrated by only using a single QD MWL chip. We have also developed a novel monolithic InAs/InP QD dual-wavelength (DW) DFB laser as a compact optical beat source to generate millimeter-wave (MMW) signals. Because of using a common cavity, highly coherent and correlated optical modes with optical linewidth as low as 15.83 kHz, spectrally pure MMW signals around 46.8 GHz with a linewidth down to 26.1 kHz were experimentally demonstrated. By using this QD DW-DFB laser, a 1Gbaud (2Gbps) MMW over-fiber transmission link is demonstrated with PAM-4 signals. The results show that the demonstrated device is suitable for high speed high capacity MMW fiber-wireless integrated fronthaul of 5G networks.
Elemental iron: reduction of pertechnetate in the presence of silica and periodicity of precipitated nano-structures

Nano-structural transformation of iron minerals in the natural environment is altered and often retarded in the presence of silica (e.g., impeded transformation of ferrihydrite) resulting in a modulated interaction with constituents or contaminants present in groundwater. This phenomenon can significantly affect molecular mechanisms of reduction, precipitation, and sequestration of pertechnetate (TcO4−), the most prevalent chemical form of radioactive contaminant technetium-99 in the environment, by elemental iron Fe0 often referred to as zero valent iron (ZVI). Understanding the role of silica in moderating the reactivity of Fe0 toward reduction of TcO4− to Tc4+ and its interaction with in situ formed iron minerals (ferrihydrite, magnetite) is crucial for successful design of a practical separation system and can be related to similar environmental systems. This study was designed to evaluate silica-modified ZVI systems with two commercially available iron materials. The results revealed that the efficiency of TcO4− reduction by Fe0 increased in the presence of silica due to inhibited transformation of iron oxyhydroxide into non-stoichiometric magnetite. Moreover, microscopic evaluation of the newly formed iron mineral phases, both in the presence and absence of silica, revealed unique morphologies related to geological phenomena, such as orbicular rocks and Liesegang rings, suggesting that iron dissolution/re-precipitation is a rhythmical reaction–diffusion process, which occurs in both micro-scaled and macro-geological environments resulting in layered structures of iron oxidation products.