cssi/SciSciGPT-SciSciNet huggingface dataset:
Fabrication and testing of large-area flexible electronics for displays and sensor arrays

The development of inexpensive high-performance electronics requiring low-temperature device processing will enable low-cost, large-area flexible electronics for applications such as large-area displays, sensors, and evolving technologies such as electric paper. The recent developments of thin-film transistor backplanes fabricated on flexible plastic substrates opens the possibility for novel device structures, processes, and applications. These new structures and processes have intrinsic difficulties that affect device yield and performance that will require new fabrication and testing procedures. For example, layer-to-layer registration on flexible substrates may require real-time alignment during patterning processes that can not be easily accomplished with conventional photolithography. In addition, the scaling of these novel techniques for fabricating flexible electronics will require new characterization techniques and monitoring systems.
Exercise interventions for upper limb dysfunction due to breast cancer treatment.

This excerpt was created in the absence of an abstract . highlights the findings and application of Cochrane reviews and other evidence pertinent to the practice ofphysical therapy. The Cochrane Library is a respected source of reliable evidence related to health care. Cochrane systematic reviews explore the evidence for and against the effectiveness and appropriateness of interventions—medication, surgery, education, nutrition, exercise—and the evidence for and against the use of diagnostic tests for specific conditions. Cochrane reviews are designed to facilitate the decisions of clinicians, patients, and others in health care by providing a careful review and interpretation of research studies published in the scientific literature.1 Each article in this PTJ series summarizes a Cochrane review or other scientific evidence on a single topic and presents clinical scenarios based on real patients or programs to illustrate how the results of the review can be used to directly inform clinical decisions. This article focuses on a woman with a diagnosis of breast cancer who underwent a modified radical mastectomy with a sentinel lymph node biopsy. She subsequently received chemotherapy and radiation therapy and required episodic physical therapy to decrease impairments and improve functional limitations. Could an exercise program for the upper limb delivered preoperatively and postoperatively and along the trajectory of adjuvant chemotherapy and radiation therapy help reduce shoulder and upper extremity impairments?
Stimulation of vesicular‐arbuscular mycorrhiza formation and growth of white clover by flavonoid compounds

summary The effects of flavonoid compounds on VA mycorrhiza root colonization and growth of white clover (Trifolium repens L.) plants under growth chamber conditions are reported. The isoflavonoids, formononetin and biochanin A, previously identified from clover roots, stimulated colonization and growth of clover, while several other flavonoid compounds were inactive when tested at concentrations of 5 mg 1−1. The flavone, chrysin, when applied at concentrations higher than those tested for formononetin and biochanin A, also increased root colonization and plant growth. The stimulatory effects of the isoflavonoids on plant growth were mediated by VA mycorrhizal fungi and were dependent on concentration, period of growth and soil spore density. Maximum responses were found when 5 mg 1−1 solutions were applied to soil containing 2 to 4 VA mycorrhiza spores g−1 of soil. These results may provide insights on the molecular mechanisms of host-fungus interaction and for the development of technology to exploit the potential of the indigenous VA mycorrhizal fungi in field soil.
Quantitative Association Analysis Using Tree Hierarchies

Association analysis arises in many important applications such as bioinformatics and business intelligence. Given a large collection of measurements over a set of samples, association analysis aims to find dependencies of target variables to subsets of measurements. Most previous algorithms adopt a two-stage approach; they first group samples based on the similarity in the subset of measurements, and then they examine the association between these groups and the specified target variables without considering the inter-group similarities or alternative groupings. This can lead to cases where the strength of association depends significantly on arbitrary clustering choices. In this paper, we propose a tree-based method for quantitative association analysis. Tree hierarchies derived from sample similarities represent many possible sample groupings. They also provide a natural way to incorporate domain knowledge such as ontologies and to identify and remove outliers. Given a tree hierarchy, our association analysis evaluates all possible groupings and selects the one with strongest association to the target variable. We introduce an efficient algorithm, TreeQA, to systematically explore the search-space of all possible groupings in a set of input trees, with integrated permutation tests. Experimental results show that TreeQA is able to handlelarge-scale association analysis very efficiently and is more effective and robust in association analysis than previous methods.
Guidelines and the use of inferior vena cava filters: a review of an institutional experience.

Summary. Background and objectives: Based on the American College of Chest Physicians 2004 antithrombotic therapy for venous thromboembolism (VTE) and the Eastern Association for the Surgery of Trauma 2002 guidelines, placement of an inferior vena cava (IVC) filter is indicated in patients who either have, or are at high risk for, VTE, but have a contraindication or failure of anticoagulation. Our aim is to compare clinical characteristics and outcomes of patients receiving IVC filters within-guidelines (WG) and outside-of-guidelines (OOG). Methods: The 558 patients who received an IVC filter were divided into two groups called WG or OOG. The WG group met the criteria described above and the OOG group did not have a contraindication to or a failure of anticoagulation. Results: The WG group had 362 patients and the OOG group had 196 patients. The OOG group had one (0.5%) patient with post-filter pulmonary embolism (PE), two (1%) with IVC thrombosis, and seven (3.6%) with deep vein thrombosis (DVT). The WG group had five (1.4%) patients with post-filter PE, 13 (3.6%) with IVC thrombosis, and 34 (9.4%) with DVT. All patients who developed post-filter PE had a DVT before filter placement, and patients who did not have a prior VTE event were at a significantly lower risk of developing post-filter IVC thrombosis and PE. Conclusion: Our data do not support the use of an IVC filter outside of guidelines in patients without prior VTE who can tolerate anticoagulation because of the low risk of developing PE.
TG/FTIR/MS study of organic compounds evolved during the co-firing of coal and refuse-derived fuels

Complementary thermal analytical techniques were used to analyze gaseous products evolved during the co-firing of coal with refuse derived fuels. The combined thermogravimetric . . . TG rFourier transform infrared FTIR rmass spectrometry MS techniques were employed to study the reaction pathways for the formation of gaseous products during combustion, as well as identify molecular chlorine, HCl, CO, CO , H O and various organic compounds. The discovery 22 of molecular chlorine has led us to look for the possible formation of chlorinated organic compounds in the combustion process. Chlorine and hydrocarbon species are released in the same temperature range and in higher concentrations during fast heating rates compared to relatively slow ones. These results indicate that there may be more opportunities to form chlorinated organic . compounds during the co-firing of coals with refuse-derived fuels RDF at the faster heating rates . that may occur in a fluidized-bed combustor FBC system. q 1999 Elsevier Science B.V. All rights reserved.
Patterns and Mechanisms of the Forest Carbon Cycle1

▪ Abstract Forests are an important source for fiber and fuel for humans and contain the majority of the total terrestrial carbon (C). The amount of C stored in the vegetation and soil are strongly influenced by environmental constraints on annual C uptake and decomposition and time since disturbance. Increasing concentrations of atmospheric carbon dioxide (CO2), nitrogen deposition, and climate warming induced by greater greenhouse gas (GHG) concentrations in the atmosphere influence C accumulation rates of forests, but their effects will likely differ in direction and magnitude among forest ecosystems. The net interactive effect of global change on the forest C cycle is poorly understood. The growing demand for wood fiber and fuel by humans and the ongoing anthropogenic perturbations of the climate have changed the natural disturbance regimes (i.e., frequency and intensity); these changes influence the net exchange of CO2 between forests and the atmosphere. To date, the role of forest products in the gl...
Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals.

Abstract Background l-arginine, the substrate for endothelial nitric oxide synthase, is essential for normal endothelial function. Aim of the present study was to investigate in healthy smokers the effect of a short-term daily l-arginine administration on vascular function. Methods We studied the effect of a 3-day oral administration of l-arginine in 10 healthy smokers (24.3±0.73 years old) on 3 occasions (day0, day1 and day3). The study was carried out on two separate arms, one with l-arginine (7 gr/d) and one with placebo according to a randomized, placebo-controlled, double-blind, cross-over design. Measurements were carried out before, immediately after (Sm0) and 20 min after (Sm20) cigarette smoking. Endothelial function was evaluated by flow-mediated dilatation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections. Results Compared to placebo, l-arginine led to an increase of FMD ( p p p p p Conclusions Short-term daily administration of l-arginine improves arterial performance in healthy smokers and abrogates the smoking-induced increase in arterial stiffness and wave reflections in these individuals.
Causes of focus-error feedthrough in optical-disk systems: astigmatic and obscuration methods

High-density magneto-optical recording systems require sensitive and robust focus position sensors that are immune to transient changes in the amplitude and the phase of the light diffracted from pregrooved media during the seek operation. The false focus-error signal produced by track crossing during seeking is termed feedthrough. Total immunity to feedthrough is never achieved, although some focus-error detection methods, notably the obscuration method, perform better in this regard. The astigmatic focus-error detection method is usually operated with a large astigmatic foci separation distance to facilitate detector alignment and to permit push–pull tracking, which increases pattern noise and contributes to its poor resistance to feedthrough. Pattern noise is caused by the projection of the intensity pattern at the exit pupil of the objective lens onto the detector plane, at which it produces false focus-error signals. The obscuration method, a diffraction-limited method of focus-error sensing, evens out this pattern noise and is therefore more resistant to feedthrough. We present numerical modeling results that compare the feedthrough performance of the astigmatic and the obscuration methods of focus-error detection.
Game theory in the death galaxy: Interaction of cancer and stromal cells in tumour microenvironment

Preventing relapse is the major challenge to effective therapy in cancer. Within the tumour, stromal (ST) cells play an important role in cancer progression and the emergence of drug resistance. During cancer treatment, the fitness of cancer cells can be enhanced by ST cells because their molecular signalling interaction delays the drug-induced apoptosis of cancer cells. On the other hand, competition among cancer and ST cells for space or resources should not be ignored. We explore the population dynamics of multiple myeloma (MM) versus bone marrow ST cells by using an experimental microecology that we call the death galaxy, with a stable drug gradient and connected microhabitats. Evolutionary game theory is a quantitative way to capture the frequency-dependent nature of interactive populations. Therefore, we use evolutionary game theory to model the populations in the death galaxy with the gradients of pay-offs and successfully predict the future densities of MM and ST cells. We discuss the possible clinical use of such analysis for predicting cancer progression.
CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging

The major histocompatibility complex I (MHCI) pathway, which canonically functions in innate immune viral antigen presentation and detection, is functionally pleiotropic in the central nervous system (CNS). Alternative roles include developmental synapse pruning, regulation of synaptic plasticity, and inhibition of neuronal insulin signaling; all processes altered during brain aging. Upregulation of MHCI components with aging has been reported; however, no systematic examination of MHCI cellular localization, expression, and regulation across CNS regions, life span, and sexes has been reported. In the mouse, MHCI is expressed by neurons and microglia, and MHCI components and receptors (H2-K1, H2-D1, β2M, Lilrb3, Klra2, CD247) display markedly different expression profiles across the hippocampus, cortex, cerebellum, brainstem, and retina. MHCI components, receptors, associated inflammatory transcripts (IL1α, IL1β, IL6, TNFα), and TAP (transporter associated with antigen processing) components are induced with aging and to a greater degree in female than male mice across CNS regions. H2-K1 and H2-D1 expression is associated with differential CG and non-CG promoter methylation across CNS regions, ages, and between sexes, and concomitant increased expression of proinflammatory genes. Meta-analysis of human brain aging data also demonstrates age-related increases in MHCI. Induction of MHCI signaling could contribute to altered synapse regulation and impaired synaptic plasticity with aging.
In Situ Measurement of Oxygen Partial Pressure in a Cathode Catalyst Layer

A micro-structured electrode scaffold (MES) was developed for performing in-situ measurements of through-plane oxygen partial pressure (OPP) distributions in the cathode of a polymer electrolyte membrane fuel cell (PEMFC). Alternating layers of insulating material and platinum are stacked and bonded, and surround a 100 micron diameter hole filled with catalyst layer material. The platinum layers serve as ultra-microelectrodes, allowing the measurement of local OPP at discrete intervals through the catalyst layer thickness. Following an investigation of ultra-microelectrode sensitivity and repeatability, pulsed amperometric detection was selected over potentiostatic operation as the most effective method for performing OPP measurements. Using calibration points at the full air and zero OPPs, the OPP distribution at a fuel cell current density of 450 mA cm-2 was measured.
Temperature, moisture, and habitat effects on Entomophthora muscae (Entomophthorales: Entomophthoraceae) conidial germination and survival in the onion agroecosystem

Conidia of Entomophthora muscae (Cohn), collected from the onion fly, Delia antiqua (Meigen), produced secondary eonidia at vapor pressure deficits from 0.0 to 3.6, but at highly reduced rates when compared with germination in free water. Germ tubes (the invasive stage) were only produced in the free-water and saturated-atmosphere treatments. Germination rates for these treatments were temperature-dependent; the optimal germination temperature was close to 21°C. The upper and lower conidial germination limits were found to be between 26.7 and 32.2°C and 1.0 and 4.4°C, respectively. Germination and survival in the field were affected by the habitat where the conidia were deposited. Onions, carrots, and grassy border areas (the main sites of E. muscae sporulation in the onion agroecosystem) affected germination and survival differentially based on the amount of cover in each canopy and the location of the conidia within the canopy. On four experimental dates, conidia experienced nearly 100% mortality after a single day of exposure to full sun. Fungicide applications were detrimental to conidial survival in the field.
Angiotensin II responses of rabbit aortic strips compared with fast and slow epinephrine responses.

SummaryEpinephrine causes a biphasic contraction of rabbit aorta, consisting of (i) a fast component, F, ascribed to release of intracellular calcium, and (ii) a slow component, S, ascribed to calcium movement into the muscle cell. Angiotensin produces a single-phase contraction of uncertain calcium source. Insight into the latter might be gained if angiotensin contractions consistently resembled the F or S epinephrine response. Contractions of rabbit aorta strips produced by both drugs were therefore compared during five interventions which had dissociated effects on F or S epinephrine responses. These interventions consistently altered the angiotensin responses in the same way as they affected epinephrine F responses, and differently from their effects on epinephrine S responses. These results are compatible with the view that the likely major source of activator calcium for angi-otensin-induced contractions of rabbit aorta is intracellular, although a small extracellular calcium contribution could not ...
Lack of Effect of Growth Hormone on Deposition of Radiostrontium in Bone.

SummaryHypophysectomized rats treated with growth hormone and consequently in a state of rapid growth, deposited in femur and mandible, when injected with radioactive strontium, essentially the same amounts of strontium, as did untreated hypophysectomized control rats injected simultaneously with the same amount of radioactive strontium.
A shamanistic fessure to catch a fleeting truth

Architectural schools extend ideology unknowingly. We have lost the primary sources essential to architectural thinking and making, that is a means of grasping, intellectually ad imaginatively, the small, evanescent details that reveal a fleeting truth. Architecture educators have allowed architecture and design to develop separately. The ideological construct of a scale through which we distinguish a building from its landscape, sublets the fractal nature of cities, which is a conversion of outer to inner — a matter of “emergence” rather than causal chains. The city embodies the human essence, the will to exist not just in the face of, but also through self-destruction. Architecture’s origins are in the shamanistic construction of fissures that allow us to make shadows to be measured with a precise musical geometry and sung to create the Real of the world.
Characterisation of patients with interstitial pneumonia with autoimmune features.

Patients with interstitial lung disease (ILD) may have features of connective tissue disease (CTD), but lack findings diagnostic of a specific CTD. A recent European Respiratory Society/American Thoracic Society research statement proposed criteria for patients with interstitial pneumonia with autoimmune features (IPAF).We applied IPAF criteria to patients with idiopathic interstitial pneumonia and undifferentiated CTD-ILD (UCTD). We then characterised the clinical, serological and morphological features of the IPAF cohort, compared outcomes to other ILD cohorts and validated individual IPAF domains using survival as an endpoint.Of 422 patients, 144 met IPAF criteria. Mean age was 63.2 years with a slight female predominance. IPAF cohort survival was marginally better than patients with idiopathic pulmonary fibrosis, but worse than CTD-ILD. A non-usual interstitial pneumonia pattern was associated with improved survival, as was presence of the clinical domain. A modified IPAF cohort of those meeting the clinical domain and a radiographic or histological feature within the morphological domain displayed survival similar to those with CTD-ILD.IPAF is common among patients with idiopathic interstitial pneumonia and UCTD. Specific IPAF features can identify subgroups with differential survival. Further research is needed to replicate these findings and determine whether patients meeting IPAF criteria benefit from immunosuppressive therapy.
Designing the Robot Behavior for Safe Human–Robot Interactions

Recent advances in robotics suggest that human–robot interaction (HRI) is no longer a fantasy, but is happening in various fields such as industrial robots, autonomous vehicles, and medical robots. Human safety is one of the biggest concerns in HRI. As humans will respond to the robot’s movement, interactions need to be considered explicitly by the robot. A systematic approach to design the robot behavior toward safe HRI is discussed in this chapter. By modeling the interactions in a multiagent framework, the safety issues are understood as conflicts in the multiagent system. By mimicking human’s social behavior, the robot’s behavior is constrained by the ‘no-collision’ social norm and the uncertainties it perceives for human motions. An efficient action is then found within the constraints. Both analysis and human-involved simulation verify the effectiveness of the method.
Situational Analysis of Physical Therapist Clinical Instructors' Facilitation of Students' Emerging Embodiment of Movement in Practice.

Background Physical therapists improve the functional ability of patients after injury and disease. A unique component of their practice is the ability to use the movement of their own bodies to effect change in their patients. This ability has been recognized as a distinctive attribute of expert physical therapists. Objective The purpose of this qualitative situational analysis study was to examine how physical therapist clinical instructors perceive and facilitate their students' emerging integration of movement in practice. Design Data collection and analysis were guided by a theoretical framework for understanding "professional ways of being." Data were analyzed using coding and mapping strategies consistent with situational analysis techniques. Methods The study included 5 physical therapist clinical instructors and their respective 5 physical therapist students. Data were collected during beginning, midterm, and final weeks of the students' clinical internships using participant interviews, observation, and document analysis. Results Coded data were summarized using situational analysis mapping strategies, resulting in 11 maps. These maps were further analyzed and reduced to 5 thematic behaviors enacted by a clinical instructor as he or she helps facilitate students' use of movement in practice. These behaviors are adapt, prepare, enhance, connect , and develop . Limitations The limited number of participants and the relative homogeneity of the student sample may have limited the diversity of data collected. Conclusions The 5 behaviors are useful when considered as a trajectory of development. To our knowledge, this study marks the first description of how physical therapist clinical instructors develop students' use of movement in practice and how to enact behaviors important in students' continued professional development. The findings are important for clinical instructors and academic programs considering how best to prepare students to use movement and develop their skills early in practice.
Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons

Synaptojanin 1 (SJ1) is a major presynaptic phosphatase that couples synaptic vesicle endocytosis to the dephosphorylation of PI(4,5)P2, a reaction needed for the shedding of endocytic factors from their membranes. While the role of SJ1's 5-phosphatase module in this process is well recognized, the contribution of its Sac phosphatase domain, whose preferred substrate is PI4P, remains unclear. Recently a homozygous mutation in its Sac domain was identified in early-onset parkinsonism patients. We show that mice carrying this mutation developed neurological manifestations similar to those of human patients. Synapses of these mice displayed endocytic defects and a striking accumulation of clathrin-coated intermediates, strongly implicating Sac domain's activity in endocytic protein dynamics. Mutant brains had elevated auxilin (PARK19) and parkin (PARK2) levels. Moreover, dystrophic axonal terminal changes were selectively observed in dopaminergic axons in the dorsal striatum. These results strengthen evidence for a link between synaptic endocytic dysfunction and Parkinson's disease.
Psychoanalytic Perspectives on Resistance

From a psychoanalytic perspective, the concept of resistance is an element of clinical theory based on repeated observations in the therapeutic situation. These clinical observations have influenced the theory and practice of psychoanalysis since Freud’s (Breuer & Freud, 1893/1955) earliest attempts to formulate a therapeutic process. Initially he used hypnosis in an attempt to promote the recall and verbal expression of otherwise inaccessible memories of psychologically traumatic experiences. When hypnosis failed with many of his patients, he subsequently substituted various other forms of suggestion and other actively directive techniques, attempting to overcome the patient’s difficulties in recovering unpleasant memories from the past.
Natural Disasters and Human Capital Accumulation: The Case of Nepal's Earthquake

Using the 1988 earthquake in Nepal as a natural experiment, we examine the long-term repercussions of a large exogenous physical shock on human capital accumulation. We exploit the quasi-random spatial and temporal nature of ground tremors to evaluate the long-term impact of earthquake on educational outcomes among affected children of rural Nepal. Results show that infants exposed to earthquake complete on average 0.6 years less schooling. Our findings further demonstrate that male infants born in earthquake-affected districts perform significantly better than the female counterparts, suggesting prospects of gender bias in an entirely patriarchal society. We also offer suggestive evidence that negative health shocks possibly influenced the long-term educational attainment of infants exposed to earthquake at an early age.
Pleasures and Paradoxes of New Media

Studying information technology and new media feels like navigating a sprawling, organic labyrinth. Flush with seeming contradiction and paradoxes, the social and technical elements of any medium or piece of technology blossom outward while simultaneously folding and refolding in on themselves in a dense, tangled-yetexpansive whorl of self and other, individual and group, human and machine.
Characteristics of Clostridium difficile infection in patients hospitalized with myelodysplastic syndrome or acute myelogenous leukemia.

Characteristics of Clostridium difficile infection in patients hospitalized with myelodysplastic syndrome or acute myelogenous leukemia
A constrained topological decomposition method for the next-generation smart grid

The inherent heterogeneity in the uncertainty of variable generations (e.g., wind, solar, tidal and wave-power) in electric grid coupled with the dynamic nature of distributed architecture of sub-systems, and the need for information synchronization has made the problem of resource allocation and monitoring a tremendous challenge for the next-generation smart grid. Unfortunately, the deployment of distributed algorithms across micro grids have been overlooked in the electric grid sector. In particular, centralized methods for managing resources and data may not be sufficient to monitor a complex electric grid. This paper discusses a decentralized constrained decomposition using Linear Programming (LP) that optimizes the inter-area transfer across micro grids that reduces total generation cost for the grid. A test grid of IEEE 14-bus system is sectioned into two and three areas, and its effect on inter-transfer is analyzed.
Sterile stamens do not enhance seed set in females of the cryptically dioecious Thalictrum macrostylum (Ranunculaceae)1

In cryptically dioecious species, at least one morph is functionally unisexual despite hermaphroditic morphology. In such species, sterile reproductive structures may indirectly increase fitness of the cryptic morph. This study manipulates pollination mode to investigate two hypotheses regarding the influence of sterile stamens on female fitness in the cryptically dioecious Thalictrum macrostylum. Pollination mode and the presence of pollen limitation in natural populations were also investigated. In two natural populations, pollen receipt on pistils was quantified in open-pollinated and pollinator-exclusion flowers with varying numbers of stamens. Seed set was quantified in additional open-pollinated flowers, a subset of which received supplemental pollen to test for pollen limitation. Females were not significantly insect pollinated at either site. Number of sterile stamens per flower was positively related to pollen receipt in open-pollinated flowers at one site, but had no influence on seed set at either site. In one population, seed set was significantly pollen limited, and high variance in seed set among pollen-addition flowers in both populations indicates that high pollen loads do not always increase seed set. In the wind-pollinated and cryptically dioecious Thalictrum macrostylum, sterile stamens in females do not appear to increase female fitness. Other explanations for the persistence of stamens and sterile pollen in females of T. macrostylum should be sought.
Biologics monitoring: incongruity between recommendations and clinician monitoring trends.

Background: Biologics are commonly used for moderate to severe psoriasis. Monitoring laboratory tests may provide little definitive benefit to patients.Objective: We queried a Humana database to gain insight regarding dermatologists' laboratory monitoring practices for psoriasis patients on biologics.Methods: Data were obtained from the Humana database. Our cohort included 333 patients with primary ICD-9 diagnosis of psoriasis (696.1) between the years 2008 and 2013 who are prescribed any biologic medication. Subjects on methotrexate, acitretin, or cyclosporine were excluded from the study. We separately queried laboratory tests by CPT codes and quantified based on frequency over a 2-year time period. Percentages of demographic group receiving a laboratory test at a given frequency category were calculated.Results: About 46% and 47% of patients received >4 comprehensive metabolic panel and complete blood count tests 2 years after starting a biologic. About 18% of individuals age >50 received greater than four Basic Metabolic Panel tests 2 years after starting a biologic.Limitations: Patient comorbidities might confound some of our findings, as these laboratory tests may have been ordered for a comorbidity rather than for biologics side effect monitoring.Conclusions: There are inconsistencies between current monitoring practices and guidelines. Clarifying biologics monitoring recommendations in psoriasis patients may reduce healthcare costs and provider workload.
Rehabilitation of head and neck cancer patients.

Patients who are treated for head and neck cancer can present with some of the most significant posttreatment morbidity of any cancer group [1–29]. Their eating, talking, respiration, and cosmesis can all be significantly altered by their treatment. All these effects may be quite visible and may interfere with socialization and employment. Therefore, rehabilitation for head and neck cancer patients about to undergo treatment should be an initial and continuing concern of the patient’s attending physician or surgeon, not the last item to be considered in the patient’s care plan [30—42]. In fact, the thinking of physicians and surgeons caring for patients with head and neck cancer has changed significantly over the last 10 years to the point where rehabilitation is usually considered at the time of treatment selection, rather than at the end of the treatment continuum. This chapter will review the particular functional problems resulting from head and neck cancer at various disease sites and the subsequent treatment(s) of this cancer and will present current thinking on aggressive rehabilitation for these patients.
Mechanisms of Precipitation of Auroral Particles

The visible aurora and other ionospheric effects, as well as direct measurements, have shown that substantial particle fluxes with energies of 1 to 100 keV are incident upon the upper atmosphere. As has been noted in Section 1.3 these particles probably originate in the solar wind. The solar wind velocity changes from the supersonic values of Table 3.3 to subsonic at the collision free shock II in Figure 1.1. Here the ordered flow velocity of the protons is largely converted to random motions so that protons and electrons in the magnetosheath region EE have thermal energies of the order of 500 eV and 100 eV respectively. In the case of electrons this energy is largely thermal even in the solar wind (see Table 3.3). In order to achieve the energies of nighttime auroral particles a 50 × or larger increase in energy must be produced. The midday red aurora discussed in Section 3.3.6b may arise from magnetosheath plasma penetrating directly into the dayside cusp or clefts F of Figure 1.1. This aurora alone may be explained without the need for an acceleration mechanism. Thanks to direct satellite explorations of the magnetosphere and the solar wind the framework within which this acceleration process must take place is fairly well defined. It is difficult by direct observation to determine the details of dynamic processes in the magnetosphere-ionosphere system, consequently optical observations of aurora constitute a powerful tool for testing ideas about the processes occurring in magnetospheric substorms. The most challenging task is to understand not only how particles are able to enter the magnetosphere and be accelerated but also to know how the fine structure and motions of auroral forms may be explained.
Abstract 2358: Uncovering novel mechanisms of resistance in AML using integrative functional genomics

Treatment options that effectively cure patients diagnosed with acute myeloid leukemia (AML) continue to represent an area of unmet need in oncology clinical care. While remission rates in AML patients can reach upwards of 90% under the current frontline therapy paradigm, nearly all patients relapse with treatment refractory disease less than 5 years after diagnosis. Relapse driven by therapy resistant cells that persist in the body after treatment (defined as minimal residual disease, or MRD) is the principal source of fatality in AML patients. Therefore, understanding how and where these leukemic cells survive treatment in vivo may help advance the rational development of highly synergistic combination therapies for the treatment of AML. Using a functional genomic approach (in vivo RNAi) and a new mouse model of AML chemoresistance (ChemoR) generated in our labs, we have identified several putative mediators of therapy resistance. Transcriptional profiling of the ChemoR model allowed us to generate a chemoresistance gene signature that we overlapped with the results of the shRNA screen to identify high-confidence genes of interest. The top genes from a ranked list of the most highly overexpressed (OE) genes in ChemoR cells and the top depleted genes from the shRNA screen in the context of therapy treatment were selected as high interest hits and subsequently tagged for individual follow-up experiments. Early validation studies suggest that some of our hits protect leukemic cells resident only at specific anatomical niches from therapy, while other proteins appear to be general chemosensitizers both in vivo and in vitro, and in both murine and human AML. Subsequent work will focus on elucidating the mechanisms by which these proteins promote resistance to frontline therapies in AML. Citation Format: Azucena Ramos, Luis R. Millan Barea, Alexandre Puissant, Nina Fenouille, Gabriela Alexe, Kimberly Stegmaier, Michael T. Hemann. Uncovering novel mechanisms of resistance in AML using integrative functional genomics [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2358.
Insomnia and risk for suicidal behavior: A test of a mechanistic transdiagnostic model in veterans.

Abstract Background Insomnia has been shown to have direct and indirect associations with suicidal ideation, attempts, and death in U.S. military and veteran populations. However, transdiagnostic models of insomnia and psychopathology have not been used to examine the contribution of psychopathology. Method The present study is a secondary analysis examining the associations among insomnia symptoms, posttraumatic stress disorder (PTSD) and depressive symptoms, interpersonal theory of suicide variables, and risk for suicidal behavior in community veterans (n = 392). Serial mediation was used to test sequential associations, allowing for examination of direct and indirect associations. Results The model with insomnia, PTSD, and depressive symptoms, and thwarted belongingness, accounted for 29% of the variance in risk. Insomnia symptoms had an indirect association through PTSD and depressive symptoms, and thwarted belongingness. The model with insomnia, PTSD, and depressive symptoms, and perceived burdensomeness accounted for 35% of the variance in risk. Insomnia symptoms had an indirect association through PTSD and depressive symptoms, and perceived burdensomeness. Limitations Data are cross-sectional, precluding the testing of causal associations. Conclusions In veterans, insomnia symptoms may be associated with increased PTSD and depressive symptoms, which may be associated with increased risk for suicidal behavior directly and indirectly through relationship disruptions.
Disseminating universal genetic testing to a diverse, indigent patient population at a county hospital gynecologic oncology clinic.

Abstract Objective The universal genetic testing initiative (UGTI) is a quality improvement effort to increase rates of guideline-based genetic counseling (GC) and genetic testing (GT) of patients with potentially hereditary cancers. The UGTI was disseminated to a county hospital gynecologic oncology clinic that serves a diverse, indigent patient population. Methods Using the Model for Improvement quality improvement framework, interventions including integrated GC, clinic tracking, assisted GC referrals, and provider education were tested over 26 months. A retrospective data review included patients with high-grade, non-mucinous epithelial ovarian, fallopian tube, and primary peritoneal cancers (HGOC) and endometrial cancers (EC) diagnosed between 9/1/12–8/31/16. Statistical analyses were performed to describe the population and to evaluate rates of recommendation and use of immunohistochemistry tumor testing (IHC), GC, and GT. Results A cohort of 241 patients (57 HGOC, 184 EC) were included. At the conclusion of the study 84.2% of HGOC patients were referred for GC, 89.6% (43/48) completed GC, and 90.7% (39/43) completed GT. Of EC patients, 81.0% were recommended to have IHC and 62.4% (93/149) completed IHC. Patients with HGOC diagnosed during dissemination of UGTI were significantly more likely to receive a recommendation for GC (p = 0.02) and to complete GT (p = 0.03) than those diagnosed before UGTI. Patients with EC were significantly more likely to complete IHC if diagnosed after UGTI than those diagnosed prior to dissemination (p Conclusions The UGTI can be adapted to increase use of guideline-based cancer genetics services in a diverse, indigent, gynecologic cancer patient population.
x-automate

Control Your Home with Linux: Mr. Benedict show us the way to live in the home of the futureusing our computer to control lights and appliances
Patterns of C P violation from mirror symmetry breaking in the η →π + π - π 0 Dalitz plot

A violation of mirror symmetry in the $\ensuremath{\eta}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}{\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\pi}}^{0}$ Dalitz plot has long been recognized as a signal of $C$ and $CP$ violation. Here we show how the isospin of the underlying $C$- and $CP$-violating structures can be reconstructed from their kinematic representation in the Dalitz plot. Our analysis of the most recent experimental data reveals, for the first time, that the $C$- and $CP$-violating amplitude with total isospin $I=2$ is much more severely suppressed than that with total isospin $I=0$.
Light stau phenomenology and the Higgs γγ rate

Recently, an excess of events consistent with a Higgs boson with mass of about 125 GeV was reported by the CMS and ATLAS experiments. This Higgs boson mass is consistent with the values that may be obtained in minimal supersymmetric extensions of the Standard Model (SM), with both stop masses less than a TeV and large mixing. The apparently enhanced photon production rate associated with this potential Higgs signal may be the result of light staus with large mixing. Large stau mixing and large coupling of the staus to the SM-like Higgs boson may be obtained for large values of tan β and moderate to large values of the Higgsino mass parameter, μ. We study the phenomenological properties of this scenario, including precision electroweak data, the muon anomalous magnetic moment, Dark Matter, and the evolution of the soft supersymmetry-breaking parameters to high energies. We also analyze the possible collider signatures of light third generation sleptons and demonstrate that it is possible to find evidence of their production at the 8 TeV and the 14 TeV LHC. The most promising channel is stau and tau sneutrino associated production, with the sneutrino decaying into a W boson plus a light stau.
Cerebrovascular Complications of CNS Infections

The most common cerebrovascular complication of infection overall is cerebral infarction. A less common complication is hemorrhage either from ruptured infective aneurysm or from vasculitic destruction of the vessel wall. The central nervous system (CNS) vasculature can be affected by systemic or local CNS infectious processes. Infections can compromise the arteries or the veins-dural venous sinuses. The arterial involvement includes (1) infectious intracranial aneurysm (IIA) or (2) infectious vasculitis. The venous involvement results in venous or dural venous sinus thrombophlebitis. We will present common imaging patterns on CT (computed tomography) and MRI (magnetic resonance imaging) of the arterial and venous complications of infections. We will approach the cerebrovascular complications of infections by anatomic distribution. The imaging findings for infective aneurysm are similar for different pathogens; also the imaging characteristics in infectious vasculitis are usually nonspecific and overlap for different organisms and even with noninfectious vasculitides. Infectious vasculitis can be caused by a large number of pathogens. In this chapter we will also discuss the most common organisms causing infectious vasculitis.
Assistive wearables: opportunities and challenges

Wearable technologies are body-worn devices, including smart clothes, e-textiles, and accessories. Wearables embed computational capabilities in garments to provide information, services and resources for end users. By being continuously worn, promptly accessible, and unobtrusive, wearable devices are well-suited to serve as assistive technologies meeting the needs of users with diverse abilities. For neurodiverse users specifically, belts have been explored to control impulsive speaking, smart clothes (such as t-shirts and caps) have been employed for emotional expression, and badges have been assessed to raise proximity awareness. Among diverse form factors, wrist-worn devices stand out due to their conventional look and popular usage. They have been explored for emotional regulation, touch monitoring, stress release, and self-regulation. Despite a growth in research and development of wearables, their application as assistive technologies for neurodiverse users is still underexplored. Challenges emerge on designing for heterogeneous users' profiles, automating assistance, increasing accuracy, and managing users' privacy. This paper discusses the main opportunities and affordances for wearables to support neurodiverse users as well as the grand challenges in the field.
A permissioned blockchain-based implementation of LMSR prediction markets

Abstract Since the seminal work by Hanson (2003), the Logarithmic Market Scoring Rule (LMSR) has become the de facto market-maker mechanism for prediction markets. We suggest in this paper three potential issues with centralized implementations of LMSR, which we refer to as the availability, security, and privacy problems. We also explain how a permissioned blockchain-based implementation of LMSR effectively solves all the above problems. Following the design science research framework (Peffers et al., 2007), our main contribution is a fully functional permissioned blockchain-based implementation of LMSR that is ready to be deployed. We believe our results are of great value not only to prediction market researchers and practitioners looking for LMSR implementations, but also to blockchain professionals looking for fully developed solutions as well as applications of suitable research frameworks to guide blockchain research and development.
Speeding up Particle Track Reconstruction using a Parallel Kalman Filter Algorithm

One of the most computationally challenging problems expected for the High-Luminosity Large Hadron Collider (HL-LHC) is determining the trajectory of charged particles during event reconstruction. Algorithms used at the LHC today rely on Kalman filtering, which builds physical trajectories incrementally while incorporating material effects and error estimation. Recognizing the need for faster computational throughput, we have adapted Kalman-filter-based methods for highly parallel, many-core SIMD architectures that are now prevalent in high-performance hardware. In this paper, we discuss the design and performance of the improved tracking algorithm, referred to as mkFit. A key piece of the algorithm is the Matriplex library, containing dedicated code to optimally vectorize operations on small matrices. The physics performance of the mkFit algorithm is comparable to the nominal CMS tracking algorithm when reconstructing tracks from simulated proton-proton collisions within the CMS detector. We study the scaling of the algorithm as a function of the parallel resources utilized and find large speedups both from vectorization and multi-threading. mkFit achieves a speedup of a factor of 6 compared to the nominal algorithm when run in a single-threaded application within the CMS software framework.
Religious and spiritual revival through a Winnicottian lens

The view of psychoanalytic theorists toward religion has proceeded along the same trajectory as sociological theory: from rejection, to ambivalence and tolerance, and on to a guarded acceptance and...