Objectively measured physical activity and one-year change in symptoms among individuals with radiographically confirmed knee osteoarthritis

s / Osteoarthritis and Cartilage 23 (2015) A82eA416 A388 of 46.8 and 43.7 (p1⁄40.37). While 23 ultimately decided against weight loss surgery, we are collecting post-operative data on the 153 patients (40 RYGB1⁄426%, 93 sleeve1⁄461%, 20 LAGB1⁄413%). Improvement in average KOOS and WOMAC scores over baseline has been observed at all intervals (67, 71, 65, and 42 responses at 1,3,6,12 month visits), with more improvement farther after surgery. At 6 months post-op, mean KOOS scores available thus far improved 29 points for pain, with mean WOMAC pain and index improving by 6 and 22 points. The %EWL correlated with knee symptoms at each interval and for all followups combined, as the smallest and largest %EWL quartiles (4-29%, 54-92%) showedmean improvements of 18 and 31 points (p1⁄40.03) in KOOS pain mirrored across KOOS and WOMAC scores. RYGB and sleeve yielded higher %EWL than LAGB (44%, 43% vs. 37%) across all intervals, and greater improvement in mean KOOS and WOMAC scores (e.g. mean KOOS pain increased by 28, 29 and 8). Neither presence nor severity of KOA severity affected knee pain improvement from weight loss. Conclusions: These data suggest that bariatric surgery improves patients’ KOA pain proportional to percent excess weight loss, with durability over time. RYGB and sleeve gastrectomy havemore impact on knee symptoms than LAGB. While patients with worse KL grades report more baseline pain and disability, as expected, x-ray severity did not impact the response to surgical weight loss. 645 OBJECTIVELY MEASURED PHYSICAL ACTIVITY AND ONE-YEAR CHANGE IN SYMPTOMS AMONG INDIVIDUALS WITH RADIOGRAPHICALLY CONFIRMED KNEE OSTEOARTHRITIS S.-H. Liu y, J.B. Driban z, C.B. Eaton x, T.E. McAlindon z, L.R. Harrold k, K.L. Lapane ¶. yClinical and Population Hlth. Res. Program, Graduate Sch. of BioMed. Sci., Univ. of Massachusetts Med. Sch., Worcerster, MA, USA; zDiv. of Rheumatology, Tufts Med. Ctr., Boston, MA, USA; xCtr. for Primary Care and Prevention, Mem. Hosp. of Rhode Island and Depts. of Family Med. and Epidemiology, Warren Alpert Med. Sch., Sch. of Publ. Hlth., Brown Univ., Providence, RI, USA; kUniv. of Massachusetts Med. Sch., Worcerster, MA, USA; Div. of Epidemiology of Chronic Diseases and Vulnerable Populations, Dept. of Quantitative Hlth. Sci., Univ. of Massachusetts Med. Sch., Worcerster, MA, USA Purpose: Physicians typically recommend exercise to patients with knee osteoarthritis (OA) to improve symptomatology. The purpose of this study is to quantify the effect of physical activity measured by accelerometer on changes in symptoms among people with knee OA. We hypothesized that greater daily minutes of physical activity would be associated with improvements in symptoms of the knee over the subsequent one-year period among individuals with OA. Methods: Using publicly available data from the Osteoarthritis Initiative, we examined changes in symptoms of the knee in the 12months following an assessment of physical activity based on accelerometry data. Participants with radiographically confirmed knee OA at the 48 months visit and complete outcomes were included (N1⁄41,059). Physical activity was assessed using GT1M ActiGraph uniaxial accelerometers at the 48month follow-up visit. Outcomemeasures were one-year change in symptoms of the knee between the 48 month and 60 month followup visits measured by Western Ontario and McMaster Universities (WOMAC) scales including pain, stiffness, and physical function. Higher scores indicate worse symptoms of the knee or knee-related function. Two variables categorizing physical activity were constructed: 1) tertiles of daily light activity; and 2) tertiles of daily moderate to vigorous activity. Descriptive characteristics and objectively measured physical activity and WOMAC scores were calculated and tested for linear trend according to tertiles of average daily minutes in light physical activity. Multivariable linear models estimated the relationship between tertiles of physical activity and changes in knee symptoms, adjusting for socioeconomic, health factors and other potential confounders. Separate models were used for light and moderate to vigorous physical activity. Stratified analyses were performed based on the disease severity measured by Kellgren-Lawrence (K-L) Grading Scale. Results: Approximately 12% of participants met 2008 U.S. Department of Health and Human Services (DHHS) physical activity guidelines for 150 minutes per week engaging in moderate to vigorous physical activity. Compared to the participants in the lowest tertile of daily time in light activity, those with higher daily minutes were more likely to be younger, women and have higher summary scores of SF-12 physical component. Relative to those in the lowest tertile of average daily minutes in light activity, those in the highest tertile had similar changes in pain and stiffness, but worse physical function (adjusted b: 1.90; 95% CI: 0.42 to 3.38); p trend 1⁄4 0.01). Higher tertiles of time spent in moderate to vigorous activity was associated with worsening pain and physical function (p trend 1⁄4 0.01 and 0.02, respectively), but not stiffness. Analyses stratified by K-L grade revealed that worsened symptoms associated with physical activity were limited to participants with K-L grade 4. Among those with K-L grade 4, participants in the highest tertile of light activity and participants in the highest tertile of moderate/vigorous activity experienced worsened pain, stiffness, and function relative to the lowest light activity tertile and lowest moderate/vigorous activity tertile, respectively. No association between physical activity and changes in symptoms were present for participants with K-L grade 2 or 3. Conclusions: Few community dwelling adults with OA achieved DHHS recommendations for physical activity. Greater time spent in objectively measured physical activity was not associated with one-year improvements in patient-reported knee symptoms among community dwelling adults with knee OA, and was associated with worsening symptoms among those with severe OA as measured for both light and moderate to vigorous objectively measured physical activity. Further research on the role of physical activity as either helpful or harmful for knee OA symptom progression based on the severity of knee OA is