cssi/SciSciGPT-SciSciNet huggingface dataset:
The Informative Role of the Value Line Investment Survey: Evidence from Stock Highlights

I examine abnormal stock returns associated with “stock highlights” published by the Value Line Investment Survey. At the time of their publication, stock highlights elicit strong positive abnormal returns. They also have positive abnormal returns at the time of the earnings announcement preceding stock highlight publications. Post-earnings announcement drift is present, but is much too small to explain abnormal returns at the time of the publication of stock highlights. Thus, Value Line stock highlights provide useful information to investors. This information is rapidly reflected in stock prices, consistent with market efficiency.
DRISP: a versatile scheme for distributed fault-tolerant queues

A versatile scheme for implementing fault-tolerant queues in a distributed system is proposed. Based on the combination of two simple concepts, by distributing replications of a queue and conducting intelligent-sequential probe (DRISP), the backbone of this work is unsophisticated, yet powerful. A description is presented of the protocols for handling a replicated and distributed queue, which is different from a replicated file in the sense that FIFO order should be maintained in a queue. The replicated distributed queue supported by these algorithms provides dynamic fault tolerance, high availability, and uniform load balancing with small storage space requirements and low communication cost. It is also adaptable to environment changes. Consistency is guaranteed. >
Both a fiction and an existential fact: Theorizing identity in second language acquisition and literacy studies

Abstract This review of literature outlines the ways that identity has been theorized in recent years in two educational sub-disciplines concerned with language and education: second language acquisition (SLA) and literacy studies. The article explores how selective appropriations from the work of Bourdieu and Foucault have informed ethnographic and case studies as well as theoretical discussions on identity and learning in these fields. It concludes by arguing that Bakhtin's theories of language have the potential to resolve some of the contradictions between continuity and change that have arisen in these discussions.
A Wide-Bandwidth 2.4 GHz ISM Band Fractional- $N$ PLL With Adaptive Phase Noise Cancellation

A fast-settling adaptive calibration technique is presented that makes phase noise cancelling DeltaSigma fractional-N PLLs practical for the low reference frequencies commonly used in wireless communication systems. The technique is demonstrated as an enabling component of a 2.4 GHz ISM band CMOS PLL IC with a 730 kHz bandwidth, a 12 MHz reference, and an on-chip loop filter. In addition to the adaptive calibration technique, the IC incorporates a dynamic charge pump biasing technique to reduce power dissipation. The worst-case phase noise of the IC is -101 dBc/Hz and -124 dBc/Hz at 100 kHz and 3 MHz offsets, respectively, and the adaptive phase noise cancellation technique has a worst-case settling time of 35 mus . The IC is implemented in 0.18 CMOS technology. It measures 2.2 x 22 mm2 and its core circuitry consumes 20.9 mA from a 1.8 V supply.
Modeling Ultrasonic Sealing of Membrane Electrode Assemblies for High-Temperature PEM Fuel Cells

Ultrasonic bonding, with its extremely fast cycle times and energy efficiency, is being investigated as an important manufacturing technology for future mass production of fuel cells. The objectives of the authors’ research are to (1) create a multi-physics simulation model that predicts through-thickness energy distribution and temperature gradients during ultrasonic sealing of polybenzimidazole (PBI) based Membrane Electrode Assemblies (MEAs) for High Temperature PEM fuel cells, and (2) correlate the model with experimentally measured internal interface (e.g., membrane/catalyst layer) temperatures. The multi-physics model incorporates the electrode and membrane material properties (stiffness and damping) in conjunction with the ultrasonic process parameters including pressure, energy flux and vibration amplitude. Overall, the processing of MEAs with ultrasonic bonding rather than a hydraulic thermal press results in MEAs that meet or exceed required performance specifications, and potentially reduces the manufacturing time from minutes to seconds.Copyright © 2011 by ASME
Estrogen Receptor Immunoreactivity in Rat Brain: Rapid Effects of Estradiol Injection*

The existence of cytoplasmic estrogen receptor immunoreactivity (ER-IR) has been reported in the brain using three different antibodies raised against different enitones on the ER nrotein. With each antibody. the darYkest reaction product was seen within cell nuclei, but cytoplasmic ER-IR was also observed with each antibody in most neuroantaomical areas. We have reported previously that an injection of estradiol causes a rapid decrease in ER-IR in ovariectomized guinea pigs when the H 222 estrogen receptor antibody was used. In extending this work to rats, we used three different ER antibodies to determine if this decrease in ER-IR is likely to be due to down-regulation of the receptor by estradiol or a decrease in the ability of some antibodies to bind to their particular epitopes on the receptor. Estradiol injection in ovariectomized rats caused a rapid (within 20 min), nearly total loss of cytoplasmic ER-IR when the H 222 antibody was used to visualize the receptor. This decrease did not appear to be due to movement of the receptors to the cell nucleus, as cell nuclear ER-IR also decreased. When other antibodies were used, the extent of loss and the pattern of immunostaining were greatly influenced by the particular antibody. Extensive loss of cytoplasmic and cell nuclear ER-IR was seen when an antiserum against the hinge region of the receptor was used. However, when an antiserum against the N-terminus of the ER was used, a decrease was seen in cytoplasmic ER-IR, but little or no decrease was observed in cell nuclear ER-IR. Because loss of cell nuclear ER-IR was not seen with all of the antibodies, these results suggest that the dramatic decrease in cell nuclear ER-IR seen immediately after estradiol injection is due at least in part to a conformational change in the receptor. This, in turn, may impede association with particular antibodies during the immunocytochemical procedure.
«Jardines vallados» y la Stationers’ Company 2.0

La llei de drets d'autor es va originar com una llei dissenyada per a regular el comerc de treballs impresos, no pas com una llei dissenyada per a protegir els interessos d'autors. L'Estatut d'Anne ho va canviar concedint els drets d'autor a l'autor, la qual cosa creava la possibilitat de negociacions de prepublicacio. Avui aquest acord s'ha trencat. En la nostra era de la computacio en nuvol i el web 2.0, els intermediaris no autors proporcionen plataformes que constitueixen les eines d'autoria, les eines de publicitat i les eines de distribucio comercial. En aquest nou ecosistema, veiem una tornada al model de la Stationers' Company, en el qual el poder legal sobre la produccio d'autor esta a les mans dels propietaris de les tecnologies intermediaries. Aixi, doncs, el futur dels drets d'autor digitals sembla cada vegada mes una tornada als seus origens, ates que els autors tenen un paper de vassalls obligats pels senyors de les plataformes on treballen.
Wigner term generated by isovector p-n pairing

The linear term proportional tojN Zj in the nuclear symmetry energy (Wigner energy) is obtained in a model that uses isovector pairing on single particle levels from a deformed potential combined with a ~ 2 interaction. The pairing correlations are calculated by numerical diagonalization of the pairing Hamiltonian acting on the six or seven levels nearest the N = Z Fermi surface. The experimental binding energies of nuclei with N Z are well reproduced. The Wigner energy emerges as a consequence of restoring isospin symmetry.
Denaturing high-performance liquid chromatography efficiently detects mutations of the acetolactate synthase gene

Abstract Acetolactate synthase (ALS), a common enzyme in the biosynthesis of branched-chain amino acids, is a target for the sulfonylurea, imidazolinone, triazolopyrimidine, pyrimidinylthiobenzoate, and the sulfonylaminocarbonyltriazolinone classes of herbicides. Widespread resistance to the ALS-inhibiting herbicides has been attributed to single-base mutations in the ALS gene. The objective of this study was to investigate the feasibility of using denaturing high-performance liquid chromatography (DHPLC), a recently developed method of mutation analysis, for the detection of three ALS mutations, Ala122Thr, Leu574Trp, and Ser653Thr, which confer herbicide resistance. The mutated variants of the ALS gene were isolated from herbicide-resistant biotypes of smooth pigweed and Powell amaranth using polymerase chain reaction (PCR). The PCR products were hybridized with a wild-type sample and subjected to DHPLC analysis. All three mutations could be detected using a modified High performance liquid chromatograph...
Interneuron Transplantation as a Treatment for Epilepsy

Stem-cell therapy has extraordinary potential to address critical, unmet needs in the treatment of human disease. One particularly promising approach for the treatment of epilepsy is to increase inhibition in areas of the epileptic brain by grafting new inhibitory cortical interneurons. When grafted from embryos, young γ-aminobutyric acid (GABA)ergic precursors disperse, functionally mature into host brain circuits as local-circuit interneurons, and can stop seizures in both genetic and acquired forms of the disease. These features make interneuron cell transplantation an attractive new approach for the treatment of intractable epilepsies, as well as other brain disorders that involve increased risk for epilepsy as a comorbidity. Here, we review recent efforts to isolate and transplant cortical interneuron precursors derived from embryonic mouse and human cell sources. We also discuss some of the important challenges that must be addressed before stem-cell-based treatment for human epilepsy is realized.
Office Supplies for Entertainment World (B)

Global Paper is a major player in the worldwide office-products market. It has served Entertainment World, a West Coast business, for many years. Entertainment World has issued an RFP for a global supply of its office products, asking for a proposal with maximum mutual partnership benefits. How should Global Paper respond to this request? This case is part of a series of cases on value-based selling. The A case (UVA-M-0719) provides the background. The B case provides the value mapping and value proposition.
When Higher Working Memory Capacity Hinders Insight.

Higher working memory capacity (WMC) improves performance on a range of cognitive and academic tasks. However, a greater ability to control attention sometimes leads individuals with higher WMC to persist in using complex, attention-demanding approaches that are suboptimal for a given task. We examined whether higher WMC would hinder insight problem solving, which is thought to rely on associative processes that operate largely outside of close attentional control. In addition, we examined whether characteristics of the insight problems influence whether this negative relationship will be revealed. In Experiment 1, participants completed matchstick arithmetic problems, which require a similar initial problem representation for all problems. Higher WMC was associated with less accurate insight problem solving. In Experiment 2, participants completed insight word problems, which require substantially different representations for each problem. Higher WMC was again negatively associated with insight, but only after statistically controlling for shared variance between insight and incremental problem-solving accuracy. These findings suggest that WMC may benefit performance on fundamental processes common to both incremental and insight problem solving (e.g., initial problem representation), but hinder performance on the processes that are unique to insight (e.g., solution and restructuring). By considering the WMC of the individual, and the nature of the insight task, we may better understand the process of insight and how to best support it. (PsycINFO Database Record
Progress Report: The Activated Coagulation Time of Whole Blood (ACT)

The activated coagulation time of whole blood (ACT) has, in the nearly ten years since its first description in the literature, proven itself one of the best laboratory tests for the control of heparin therapy, both for patients undergoing treatment for thromboembolic disease and for those on extracorporeal circulation. It is simple, largely free from subjective variation, precise, and quick. Prolongation of the ACT in the heparinized individual is directly proportional to the concentration of heparin in the blood, and the test accurately reflects the semilogarithmic disappearance of the anticoagulant effect in most patients. In addition, the test serves well as a bedside screening test for deficiencies of the intrinsic coagulation mechanism. The author summarizes the sutdies that have been carried out on this technic since its original description, and briefly presents three protocols for heparinization of patients who have thromboembolic disease.
Abnormal Tubulovesicular Particles in Brains of Hamsters with Scrapie

AbstractAbnormal tubulovesicular particles of an average diameter of 23 nm have been observed in brains of mice with scrapie as well as in other animals with spongiform encephalopathies, but they were thought to be absent from the brains of hamsters with scrapie in which the highest known concentrations of the infectious agent occur. We observed in neuronal processes of hamsters as well as mice clusters of those tubulovesicular structures, most often in postsynaptic terminals. Such particles have now been seen regularly in both experimental and natural scrapie in all species examined as Well as in Other Spongiform encephalopathies.
Pitfalls of appropriating prestigious theories to frame conceptual arguments

Researchers are often encouraged to shape an existing theoretical framework around their arguments to make them more convincing to readers. This can improve the coherence of their narratives and better ground them in existing literature. However, overarching theoretical frameworks can in many cases serve to insulate the author’s unique and presumably novel arguments from criticism concerning omitted variables and ambiguous causal direction. After discussing reasons authors appropriate external theoretical frameworks into their papers I suggest that relying on a small number of prestigious overarching theories as explanatory, rather than simply organizational frameworks may have subtle and pernicious influences on inquiry by (a) restricting the boundaries of the phenomena that are considered relevant, (b) introducing barriers to changing or supplanting theories, (c) biasing estimation of relationships due to omitted variables, (d) encouraging authors to exclude contradictory evidence and insights from thei...
Team Pay-For-Performance The Devil is in the Details

Teams are an important part of most organizations. As such, it is necessary that organizational leaders make a number of decisions regarding how to pay teams. In this article, prominent themes in the teams literature and the pay-for-performance literature are integrated to develop a framework of team pay-for-performance effectiveness. Using this framework as a guide, the literature on team pay-for-performance is reviewed. Important dimensions of the team pay-for-performance construct are identified, and mediating paths between these dimensions and team outcomes are clarified. This integration leads to identification and discussion of valuable areas for future work.
Are Ethics Training Programs Improving? A Meta-Analytic Review of Past and Present Ethics Instruction in the Sciences

Given the growing public concern and attention placed on cases of research misconduct, government agencies and research institutions have increased their efforts to develop and improve ethics education programs for scientists. The present study sought to assess the impact of these increased efforts by sampling empirical studies published since the year 2000. Studies published prior to 2000 examined in other meta-analytic work were also included to provide a baseline for assessing gains in ethics training effectiveness over time. In total, this quantitative review consisted of 66 empirical studies, 106 ethics courses, 150 effect sizes, and 10,069 training participants. Overall, the findings indicated that ethics instruction resulted in sizable benefits to participants and has improved considerably within the last decade. A number of specific findings also emerged regarding moderators of instructional effectiveness. Recommendations are discussed for improving the development, delivery, and evaluation of eth...
Pan-Caribbean Synecdoche: Coloniality and the Haitian Revolution

Review of Victor Figueroa, Prophetic Visions of the Past: Pan-Caribbean Representations of the Haitian Revolution.
Abstract C54: High caveolin-1 expression in a cohort of African American women with triple-negative breast cancer

In the U.S., the incidence rates of breast cancer (BC) among Caucasian (CA) women are lower than those of African American (AA), however, AA women have a significantly higher mortality rate. AA women often present at a younger age, with later stage and higher grade tumors. In fact, AA women are 3x more likely to be diagnosed with the more aggressive molecular subtype, triple-negative breast cancer (TNBC), than CA women. Socioeconomic and lifestyle factors may be contributory; however, it is imperative that we investigate the underlying molecular biology that may be the cause of health disparities between AA and CA with TNBC. In this study, gene expression profiling, using the Almac BC DSA Research Tool, was performed on archived FFPE samples, obtained from CA and AA women diagnosed with early stage (Node 0) TNBC. Unsupervised hierarchical clustering revealed a pattern of differential gene expression in the AA cohort compared to CA. Using the TNBC type: A Subtyping Tool for TNBC, we found a distinct distribution pattern of TNBC molecular subtypes in the AA cohort, which was very different than the CA cohort; Basal-like (14%), Immunomodulatory (43%) and Mesenchymal (43%). Gene expression analyses, comparing the AA and CA cohort (fold change > 2.0, p-value Citation Format: Julie E. Getz, Davyd B. Teoh, Sara Nasser, Christophe R. Legendre, Waibhav Tembe, Venkata Yellapantula, Mary Ellen Ahearn, Carmen R. Gomez, Merce Jorda, Shuk Mei Wong, Mark D. Pegram, John D. Carpten, Lisa L. Baumbach-Reardon. High caveolin-1 expression in a cohort of African American women with triple-negative breast cancer. [abstract]. In: Proceedings of the Eighth AACR Conference on The Science of Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Nov 13-16, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2016;25(3 Suppl):Abstract nr C54.
Indirect impacts of invaders: A case study of the Pacific sheath-tailed bat (Emballonura semicaudata rotensis)

Abstract Although many indirect consequences of biological invasions are plausible, few studies test hypotheses for management of threatened taxa. A case study of the endangered Pacific sheath-tailed bat ( Emballonura semicaudata rotensis ) illustrates the importance of investigating indirect effects of invasion on species of conservation concern. We hypothesized that two invaders, feral goats and Lantana camara , would indirectly affect the bat by decreasing availability of suitable resources. Specifically, that microclimate and bat prey abundances in lantana shrub differ from native forest habitat, and that preferential browsing by goats structures forests to be less suitable for bats. Our results suggest that bats avoid lantana shrub. However, we found no evidence that preferential goat browsing influenced bat activity. Our research implies that the impact of lantana on the persistence of the bat has been underestimated and that it is unclear how goats alter bat habitat aside from reducing understory vegetation. Future managers should prioritize efforts that restore native forest and reforest areas currently dominated by lantana. We urge conservation scientists to evaluate indirect effects of invasive species and publish findings that elucidate the consequences for native populations.
The Counter-Conduct of Medieval Hermits

The hermit posed a challenge to a medieval Church that emphasized rule, order, and discipline since oversight of their life could be virtually non-existent. The writings of Richard Rolle, hermit, negotiates the space between Foucauldian exomolgesis and exoagouresis as Rolle strove to articulate the identity of the hermit without any kind of church endorsement. As well, he forged his life out of a struggle with concepts of medieval sin, specifically Pride, which placed him in a queer position in terms of relationships with his surrounding community. His way of life was highly influential in his local community, however, and, through manuscript dissemination, beyond. Because he experienced mystical visions without church oversight, his eremitic life and example inspired a movement toward lay, affective piety in the later Middle Ages. The hermit, in his case, challenges the medieval Church’s hierarchy in that hermits practice a form of living at a local level, placing them in dangerous, sometimes heretical, positions that force the Church to either absorb their practices or suppress them.
Development and Application of a Stepwise Assessment Process for Rational Redesign of Sequential Skills-Based Courses

Objective. To develop and apply a stepwise process to assess achievement of course learning objectives related to advanced pharmacy practice experiences (APPEs) preparedness and inform redesign of sequential skills-based courses. Design. Four steps comprised the assessment and redesign process: (1) identify skills critical for APPE preparedness; (2) utilize focus groups and course evaluations to determine student competence in skill performance; (3) apply course mapping to identify course deficits contributing to suboptimal skill performance; and (4) initiate course redesign to target exposed deficits. Assessment. Focus group participants perceived students were least prepared for skills within the Accreditation Council for Pharmacy Education's pre-APPE core domains of Identification and Assessment of Drug-related Problems and General Communication Abilities. Course mapping identified gaps in instruction, performance, and assessment of skills within aforementioned domains. Conclusions. A stepwise process that identified strengths and weaknesses of a course, was used to facilitate structured course redesign. Strengths of the process included input and corroboration from both preceptors and students. Limitations included feedback from a small number of pharmacy preceptors and increased workload on course coordinators.
Gallium Arsenide versus Silicon — Applications and Modelling

Silicon is the most important material for semiconductor electronics. Silicon devices and integrated circuits are dominant in most applications -- from consumer electronics to computers, from automotive electronics to sensors and imagers. However, in certain areas, silicon is being challenged by other semiconductor materials, such as gallium arsenide and related compounds. Gallium arsenide devices and monolithic microwave integrated circuits excel in ultra-high frequency applications. Gallium arsenide digital integrated circuits have emerged as leading contenders for ultrahigh speed applications in the next generation of supercomputers and communication equipment. These new technologies are located much earlier on the learning curve and their relative importance is expected to increase sharply in the near future.
Using magnetic fly ash to identify post-settlement alluvium and its record of atmospheric pollution, central USA

Abstract Fly ash has been atmospherically dispersed from coal burning in the central USA since the 1860s and subsequently incorporated into post-European settlement alluvial records. Regionally, the onset of significant coal burning approximately coincides with widespread land clearing for agriculture and accelerated erosion. Field identification of post-settlement alluvium (PSA) is difficult in many areas where the record lacks apparent contrast with older alluvium. Here, we show the PSA basal contact can be reliably identified based on the occurrence of magnetic fly ash. Fly ash methodology is relatively simple, effective, and inexpensive. The proportion of spheroidal fly ash grains in silt-size magnetic fractions was evaluated from 17 sites in the Upper Sangamon River Basin, central Illinois. Data indicate the PSA is 25–95 cm thick, increasing linearly with valley width (r2 = 0.74). Yet, the proportion of PSA within Holocene alluvium is inversely and linearly correlated with valley width (r2 = 0.87), implying significant storage of recent sediment in tributary valleys. A peak in fly ash content (∼15–50 cm in Sangamon Valley), circa 1945–1980, is coeval with peaks in 137Cs (cesium), Pb (lead) concentrations, magnetic susceptibility, and silt content during a time of maximal atmospheric pollution and accelerated topsoil erosion. Sharp decreases in fly ash in the upper 10–20 cm (post-1980) of some Sangamon Valley sites coincide with the implementation of particulate pollution controls and reductions in 137Cs and Pb concentrations; more sandy alluvium also suggests proportionally increased stream bank erosion relative to upland erosion. PSA sedimentation averages ∼5 mm/yr, an order of magnitude faster than pre-settlement rates, reflecting impacts of agriculture and other land-use changes.
Intrinsic absorption and photoconductivity in single crystal SiTe2

Abstract Optical absorption in single crystal SiTe2 has been studied at 300°K throughout the wavelength range 0·3–10 μ. Platelet type samples were prepared by iodine vapor transport. On the basis of the absorption measurements SiTe2 has been classified as an indirect gap semiconductor with a threshold for phonon assisted transitions in the neighborhood of 1·85 eV. An analysis of the functional dependence of the fundamental absorption edge on photon energy indicates the existence of a direct transition with a band gap at 2·18 eV. Photoconductive spectral response curves show a peak response at 2·16 eV. The photoresponse observed away from the direct band gap has been attributed to the effects of rapid chemical decomposition which is known to occur on the surface of crystalline SiTe2.
Can incentives mitigate student overconfidence at grade forecasts

Research shows that college students exhibit bias in their forecasts of exam performance. Most students are overconfident in their forecasts, academically weaker students are the most overconfident...
Single-pedicle hinge flap performed by shelter medicine team resolves chronic antebrachial wound in a cat

Case summaryAn approximately 3-year-old, male domestic longhair cat was presented to a mobile veterinary unit for routine neuter. Preoperative physical examination revealed an approximately 5 cm × ...
Wideband single-layer Fabry-Pérot cavity antenna with a radial variation of the cavity permittivity

A broadband single-layer Fabry-Perot Cavity antenna formed by a thin metallic frequency-selective-surface over a grounded non-uniform dielectric slab having a radial variation in the permittivity is designed. The performance of the proposed design is investigated using full-wave simulations.
Transcatheter Aortic Valve Replacement in Low-Flow Aortic Stenosis: Treat the Flow or Treat the Patient?

Aortic valve calcification and mechanical stenosis is a common finding in advanced age and has a progressive course. Myocardial dysfunction and remodeling, on the other hand, is a common entity in advanced age and could be caused by a wide variety of sources (from a mechanical sequel of valvular
Condensed-Phase Photochemistry in the Absence of Radiation Chemistry

We report postirradiation photochemistry studies of condensed ammonia using photons of energies below condensed ammonia’s ionization threshold of ∼9 eV. Hydrazine (N2H4), diazene (also known as dii...
Implications for global change

Chapter 1 described, on a global scale, the material fluxes driven by energy from the sun. In subsequent chapters the focus narrowed to the ecosystem scale, or to areas small enough to be relatively homogeneous but large enough to be regarded as self-sustaining ecological units, except for possible inputs and losses of nutrients. A variety of phenomena that can be mechanisms involved in environmental problems at the ecosystem scale were touched on in earlier chapters. Several of these are listed in Table 12.1.
Propylene Oxide Formation on a Silica Surface with Peroxo Defects: Implications in Astrochemistry

The formation of the chiral molecule propylene oxide (CH3CHCH2O) recently detected in the interstellar medium (ISM) is proposed to take place on an amorphous silicate grain surface where peroxo defects are present. A computational analysis conducted at the DFT and MP2-F12 levels of theory on a neat amorphous silica model supports such a hypothesis resulting in (a) strong thermodynamic driving forces and low activation energies allowing the synthesis of CH3CHCH2O at low temperatures, (b) chemical defects on silica surfaces promoting heterogeneous catalysis of the increasing molecular complexity found in interstellar and circumstellar medium, and (c) chemical defects that have implications on understanding how processing phases modify the nature of the reactive groups on a silica surface affecting the surface catalytic activity.
Exploring the use of an integrative and ecological framework when treating children with trauma.

ABSTRACTChildren’s clinical symptoms can often only be understood within their individual and family contexts. However, contemporary research has pointed to the importance of also working with children’s social identities and macrosystem environment when attempting to understand and treat clinical problems. The case of a 10-year-old Dominican-American girl who presented with a significant trauma history, oppositional behavior, and difficulties interacting with her peers is examined using a developmental ecological framework. Attachment theory, cognitive behavioral therapy, narrative therapy, and multicultural family systems therapy, with a focus on trauma responses, are integrated when exploring the case. Additionally, the benefits of exploring the influence of social identities (race, ethnicity, immigration status/perceived immigration status, and class) are explored via an approach that focus on transformation and healing from oppressive systems by integrating sociopolitical realities in therapy.
KAJIAN PERUBAHAN SOSIAL BUDAYA DI PESANTREN NURUL IMAN

As a religious educational institutions, boarding schools since the first until now had a strategic role in the community. Pesantren are traditional Islamic educational boarding students live with and study under the guidance of a teacher who is better known by scholars. Pesantren now have fairly rapid growth, including exposure to the development of science and technology, so now it's not only religious knowledge is taught in pesantren curriculum but also in science and technology that are already included in the curriculum of modern education in boarding schools. The purpose of this study was to find out about the development of boarding until now, the activities at the school, and social culture that became a tradition at the school. The method used in this research is descriptive qualitative method. The results showed that the boarding school has developed very rapidly, and the presence of broader changes in the field of science and technology. Kiai and boarding are two things that can not be separated. The role of the pesantren kiai is very important. Scholars through the development of science and technology can be disseminated in a boarding school curriculum. The presence of electronic media and communication media at the school shows that boarding schools are already open to everything related to modern technology. Keywords: Socio-Cultural, Pesantren
Assessing Assessment Literacy: Are new teachers prepared to assume jobs in school districts engaging in grading and assessment reform efforts?

Abstract Grading and assessment practices of K-12 educators in the U.S. continue to be among the most discussed areas in school reform and school leaders question whether or not new teachers are prepared to engage in this type of work. The purpose of this qualitative study was to better understand the phenomenon of being a new teacher in a school that uses innovative methods such as standards-based or standards-referenced grading (SBG). The finding of this study indicated that limits to preparedness as a professional was due to teacher education training on assessment, which was inconsistent at best.
Cognitive heterogeneity in probable Alzheimer disease: Clinical and neuropathologic features

Objective To identify heterogeneity in cognitive profiles of patients with probable Alzheimer disease (AD) who have mild to moderate dementia and satisfy inclusion and exclusion criteria for a typical AD clinical trial, and to determine whether cognitive profiles are systematically related to the clinical course and neuropathologic features of the disease. Methods Neuropsychological test data from patients with mild to moderate probable AD (n = 4,711) were obtained from the National Alzheimer9s Coordinating Center. Inclusion and exclusion criteria usually used in AD clinical trials were applied. Principal component analysis and model-based clustering were used to identify cognitive profiles in a subset of patients with autopsy-verified AD (n = 800) and validated in the overall (nonautopsy) sample and an independent cohort with similar test data. Relationships between cognitive profile, clinical characteristics, and rate of decline were examined with mixed-effects models. Results In the autopsy-confirmed sample, 79.6% of patients had a typical AD cognitive profile (greater impairment of episodic memory than other cognitive functions), and 20.4% had an atypical profile (comparable impairment across cognitive domains). Similar results were obtained in the overall (typical 79.8%, atypical 20.2%) and validation (typical 71.8%, atypical 28.2%) samples. Atypicality was associated with younger age, male sex, lower probability of APOE e4, less severe global dementia, higher depression scores, lower Braak stage at autopsy, and slower cognitive decline. Conclusion We can reliably identify distinct cognitive profiles among patients with clinically diagnosed probable AD that are associated with tangle pathology and with different rates of decline. This may have implications for clinical trials in AD, especially therapies targeting tau.
Investigating teacher adoption of authentic pedagogy through lesson study

In this article, we investigated the level of transfer of authentic pedagogy among 12 classroom teachers after participating in a three-year professional development project using scaffolded lesson...
Lacrimal duct probing in the treatment of congenital dacryocystitis

Objective To evaluate the effect of lacrimal duct probing in the treatment of congenital dacryocystits.Methods A retrospective study of 839 patients with congenital dacryocystitis who underwent lacrimal duct probing was reviewed.Results Of 832 cases (998 eyes) were cured by lacrimal duct probing.The cure rate was 99.10％.Two eyes suffered from subcutaneous edema and 3 eyes had hemorrhage,but there was not any severe complication.Conclusions The effects of lacrimal duct probing are related to the causes of obstruction of lacrimal duct.Lacrimal duct probing is an effective and simple method for treatment of congenital dacryocystitis with no severe complication. Key words: Congenital dacryocystitis; Lacrimal duct probing
Rejuvenating the periorbital area using platelet-rich plasma: a systematic review and meta-analysis

Intradermal injection of autologous platelet-rich plasma (PRP) is a non-surgical cosmetic therapy to rejuvenate the periorbital area pathologies of wrinkles, periorbital hyperpigmentation (POH), and photoaging. The past decade has seen the adoption of this novel therapy around the world. This is the first systematic review and meta-analysis evaluating PRP treatment of periorbital pathologies. This is a PRISMA compliant review that includes a comprehensive search of the databases Cochrane Library, Ovid Medline, Ovid Embase, and clinicaltrials.gov. The search was performed in June 2019 to obtain all peer-reviewed articles published in English that describe the application of PRP to periorbital pathologies. A meta-analysis of patient satisfaction was performed for randomized controlled trials. Nineteen studies treating 455 patients (95% female, age range 28–60) were included. Studies were categorized based on reported outcomes: wrinkles (11 studies), POH (7 studies), and photoaging (6 studies). Patients were treated a mean of 3 times (range 1–8) in mean intervals of 23 days (range 14–56 days). Follow-up averaged 3 months (range 1–6 months). Meta-analysis of 3 randomized controlled clinical trials (RCTs) shows that patients treated with PRP have increased satisfaction above controls of saline, platelet-poor plasma, mesotherapy, and as an adjunct to laser therapy (overall effect p = 0.001, heterogeneity I2 = 64%). PRP treatment of periorbital area pathologies results in histologic improvements of photoaging, subjective satisfaction score increases, and blind evaluator assessments of rejuvenated skin appearance. Future studies are needed to address limitations of the current literature and should include long-term follow-up, delineation of the POH etiology that is treated, RCTs with low risk of bias, and be absent conflicts of interest or industry sponsors. Trial registration: Prospero Systematic Review Registration ID: CRD42019135968
Case report: 68 yo Chinese-American woman with high HDL-C and ischemic stroke attributed to intracranial atherosclerotic stenosis

Abstract Atherosclerotic cardiovascular disease (ASCVD) events are the most common cause of death in the United States and for most individuals who experience these events, may be predicted by risk identification tools. ASCVD risk calculators enable a clinician-patient discussion and the presence of risk-enhancing factors may further inform decision-making with respect to preventive pharmacotherapy, especially statin prescription. In cases where the decision of whether to treat with medicine is unclear, coronary artery calcium scoring by computed tomography offers enhanced risk stratification and may allow both clinicians and patients to feel more at ease with the decision to withhold statin therapy. Despite this thoughtful approach, individual risk may still be underestimated. We present a case of a woman whose family history suggested increased short- and long-term ASCVD risk due to intracranial atherosclerosis, but whose tests suggested a more equivocal indication for treatment. Neither she nor her clinician appreciated the presence of significant enough risk to persevere through minor statin side effects for primary prevention, but she was lucky to have survived without appreciable harm from an acute cerebrovascular event and is now able to pursue an appropriate secondary preventive strategy. We discuss how exceptional characteristics may mislead clinicians, including misperception about lower risk due to gender, East Asian predisposition to intracranial more than coronary atherosclerosis, high levels of high density lipoprotein cholesterol (HDL-C), and CACS = 0.
Evaluation of spin in the abstracts of orthopedic trauma literature: A cross-sectional review.

Abstract Objectives A cross-sectional analysis of orthopedic trauma randomized controlled trial (RCT) abstracts to assess the frequency and manifestations of spin, the misrepresentation or distortion of research findings, in orthopedic trauma clinical trials. Methods The top 5 orthopedic trauma journals were searched from January 1, 2012, to December 31, 2017. RCTs with nonsignificant endpoints (p > .05) were analyzed for spin in the abstract. The primary endpoint of our investigation was the frequency and type of spin. The secondary endpoint was to assess whether funding source was associated with the presence of spin. Due to the low reporting of funding sources no statistics were able to be computed for this outcome. Results Our PubMed search yielded 517 articles. Primary screening excluded 303 articles, and full text evaluation excluded an additional 161. Overall, 53 articles were included. Spin was identified in 35 of the 53 (66.0%) abstracts analyzed. Evidence of spin was found in 21 (39.6%) abstract results sections and 22 (41.5%) abstract conclusion sections. Of the 21 RCTs reporting a clinical trial registry, 3 (14.3%) had evidence of selective reporting bias. Conclusions Orthopedic trauma RCTs from highly ranked journals with nonsignificant endpoints published from 2012 to 2017 frequently have spin in their abstracts. Abstracts with evidence of spin may influence a reader's perception of new drugs or procedures. In orthopedic trauma, the implications of spin may affect the treatment of patients with orthopedic trauma, so efforts to mitigate spin in RCT abstracts must be prioritized.
Touching Information with DIY Paper Charts & AR Markers

Fostering data literacy has largely been the domain of formal educational systems and export-oriented tools. Informal educational approaches, such as games or family activities, may overcome barriers to engaging with data by fostering data literacy through casual engagement. This work in progress explores how informal learning through creation and play with interactive data representations (physicalizations) can foster increased literacy and engagement with data. We outline a series of DIY paper charts using AR markers and everyday materials to help children interact and explore data through the creative process of making.
Alternative management of delayed spontaneous oesophageal perforation by endoscopic stenting

Boerhaave's syndrome or spontaneous perforation of the oesophagus is a life-threatening condition that carries high mortality. Delayed diagnosis has a mortality rate of 20%-50%. While surgical intervention has been the mainstay of treatment, advancements in endoscopy and oesophageal stenting have allowed for alternative management. Our case involves a 33-year-old man with self-induced emesis and DKA. After 10 days in the ICU, he developed a large right pleural effusion, which was treated with chest tube placement. Upper GI study confirmed delayed Boerhaave's syndrome. A self-expanding stent was inserted followed by percutaneous endoscopic gastrostomy (PEG) for decompression and jejunal extension for nutrition. He developed empyema and underwent right thoracotomy for washout and lung decortication. Stent was exchanged once due to recurrent leak following migration and removed after 40 days. Endoscopic stent placement with PEG with jejunal extension followed by thoracotomy is a viable alternative to primary repair of delayed oesophageal perforation.
Association between City-wide Lockdown and COVID-19 Hospitalization Rates in Multigenerational Households in New York City

ABSTRACT Background City-wide lockdowns and school closures have demonstrably impacted COVID-19 transmission. However, simulation studies have suggested an increased risk of COVID-19 related morbidity for older individuals inoculated by house-bound children. This study examines whether the March 2020 lockdown in New York City (NYC) was associated with higher COVID-19 hospitalization rates in neighborhoods with larger proportions of multigenerational households. Methods We obtained daily age-segmented COVID-19 hospitalization counts in each of 166 ZIP code tabulation areas (ZCTAs) in NYC. Using Bayesian Poisson regression models that account for spatiotemporal dependencies between ZCTAs, as well as socioeconomic risk factors, we conducted a difference-in-differences study amongst ZCTA-level hospitalization rates from February 23 to May 2, 2020. We compared ZCTAs in the lowest quartile of multigenerational housing to other quartiles before and after the lockdown. Findings Among individuals over 55 years, the lockdown was associated with higher COVID-19 hospitalization rates in ZCTAs with more multigenerational households. The greatest difference occurred three weeks after lockdown: Q2 vs. Q1: 54% increase (95% Bayesian credible intervals: 22 – 96%); Q3 vs. Q1: 48%, (17 – 89%); Q4 vs. Q1: 66%, (30 – 211%). After accounting for pandemic-related population shifts, a significant difference was observed only in Q4 ZCTAs: 37% (7 –76%). Interpretation By increasing house-bound mixing across older and younger age groups, city-wide lockdown mandates imposed during the growth of COVID-19 cases may have inadvertently, but transiently, contributed to increased transmission in multigenerational households. Funding National Center for Advancing Translational Sciences; Clinical and Translational Science Center at Weill Cornell Medical College.
Primary thromboprophylaxis to prevent thrombotic events in pediatric oncology patients with a malignant mediastinal mass

Children with malignant mediastinal masses have increased thrombotic events (TE). Eligible subjects with malignant mediastinal masses between January 2000 and December 2017 were evaluated for TE, with 19 among 76 subjects receiving enoxaparin thromboprophylaxis. There were 13 TEs among 76 subjects for an incidence of 17.1%. Mediastinal compression directly led to TE in 9.2% of subjects who also had statistically significant superior vena cava compression at diagnosis. Primary thromboprophylaxis did not significantly affect TE occurrence; however, larger studies are warranted to consider strategic thromboprophylaxis guided by radiological monitoring of dynamic vascular compression to improve TE outcomes.
Red blood cell transfusions increase fecal calprotectin levels in premature infants

Objective We hypothesized that red blood cell (RBC) transfusions influence intestinal inflammation in very low birth weight (VLBW) infants. We also suspected that hematocrit (Hct) at transfusions and RBC storage time correlate with intestinal inflammation. Study design VLBW infants, without major congenital defects, intestinal perforation or necrotizing enterocolitis, were enrolled prospectively. Fecal calprotectin (FC) levels were measured from stool samples collected before and after RBC transfusions. Data on Hct and RBC storage time were collected. Result Data from 42 RBC transfusions given to 26 infants revealed that FC levels increased faster than baseline after RBC transfusions (P=0.018) and were higher in multiple-transfused infants (0 to 48 and >48 h post transfusion, P=0.007 and P=0.005, respectively). Lower Hct and RBC storage >21 days correlated with higher FC levels (P=0.044 and P=0.013, respectively). Conclusion RBC transfusions, anemia and prolonged RBC storage were associated with an increase in intestinal inflammation.
Thriving Systems Through Metaphor-Driven Modeling

Computer-based information systems are certainly among the most complex constructions conceived by humankind. And more often than not, those constructions that may be more complex include embedded information systems of some kind. To address the total range of issues and all the variations of process that are or can be employed in the development of information systems is far beyond the scope of this monograph. Thus, the goal here is to focus on the modes of perception, representation, and understanding that lead to the success of all those efforts expended regardless of any particular paradigm, technology, or methodology – and in doing so, to propose an enlightened context within which to consider those paradigms, technologies, and methodologies.