cssi/SciSciGPT-SciSciNet huggingface dataset:
Late gastric conduit ischemia from celiac artery stenosis salvaged by stent therapy.

Gastric conduit necrosis after esophagectomy usually presents early in the postoperative phase. The etiology of this ischemia most often lies in the inability of the isolated right gastroepiploic artery to provide adequate blood supply to the entire conduit. Here we describe an unusual presentation of late gastric conduit ischemia, occurring many years after surgery as a result of atherosclerosis and stenosis of the celiac artery. Successful salvage of the gastric conduit was achieved with stenting of the celiac artery.
Are We Up to Speed?: From Big Data to Rich Insights in CV Imaging for a Hyperconnected World

The first software implementation of the heat map display was developed in 1991 [(1)][1] and has been used since then as a mainstream tool in systems biology for communicating interactions among genes, proteins, and metabolites that define life processes. In general, heat maps are considered a
Superficial Zone Extracellular Matrix Extracts Enhance Boundary Lubrication of Self-Assembled Articular Cartilage

Previous work has shown that increasing the production of boundary lubricant, superficial zone protein (SZP), did not reduce the friction coefficient of self-assembled articular cartilage constructs and was possibly due to poor retention of the lubricant. The aim of this investigation was to reduce the friction coefficient of self-assembled articular cartilage constructs through enhancing SZP retention by the exogenous addition of extracellular matrix (ECM) extracted from the superficial zone of native articular cartilage.Superficial zone cartilage was shaved from juvenile bovine femoral condyles using a dermatome, minced finely with razor blades, extracted with 4 M guanidine-hydrochloride, buffer exchanged with culture medium, and added directly to the culture medium of self-assembled articular cartilage constructs at low (10 µg/mL) and high (100 µg/mL) concentrations for 4 weeks. Biochemical and biomechanical properties were determined at the conclusion of 4 weeks culture.ECM treatment increased compressive and tensile stiffness of self-assembled articular cartilage constructs and decreased the friction coefficient. Glycosaminoglycan content decreased and collagen content increased significantly in self-assembled constructs by the ECM treatment.Friction coefficients of self-assembled articular cartilage constructs were reduced by adding extracted superficial zone ECM into the culture medium of self-assembled articular cartilage constructs.
War Against the Idols: ERASMUS AS CRITIC OF LATE MEDIEVAL PIETY

W hen the city of Basel erupted into a violent iconoclastic riot in February 1529, Erasmus remarked in one of his letters: “I am greatly surprised that the images performed no miracle to save themselves; formerly the saints worked frequent prodigies for much smaller offenses.” Unlike the pilgrims at Tallard, the great humanist had difficulty believing in the power of images. In fact, few men in Europe had done as much to discredit the materialism of medieval piety as had Erasmus. When Guillaume Farel rejected everything his childhood pilgrimage stood for, his decision was formed, to a large extent, by ideas that can be traced directly to Erasmus. One of the most hackneyed aphorisms concerning the relationship between humanism and the Reformation is that which blames Erasmus for laying the egg that Luther hatched. Risking all the dangers that attend the stretching of metaphors, I think it is possible to say that Erasmus laid more than one egg; and that those hatched in succession by Karlstadt, Zwingli, Farel, and Calvin resembled their parent more closely in some respects than Luther's ever did. Regarding the issue of worship, or piety, a clear line can be traced between Erasmus and the Reformed tradition. Though Erasmus, the sardonic pacifist, could not stomach the “virulence” of Protestant iconoclasts, he was at heart in agreement with some of their basic assumptions regarding worship.
A Choice Sets Model of Retail Selection

The authors present a method that retail managers can use to assess competitive effectiveness and identify opportunities for improvement as consumers move through the choice process. The basis of t...
Numerical simulation of quasi-steady, single aluminum particle combustion in air

A two-dimensional numerical model of aluminum particle combustion in air is presented. This model includes nine reactions: two surface, three gaseous, one dissociation and three condensation. The initial combustion of an aluminum particle, free falling in air, shows the reaction is similar to the diffusion controlled combustion process due to the fast reaction between aluminum vapor and oxygen. The flame zone thickness is about three times that of the particle radius and at the flame zone the temperature flattens due to the dissociation of aluminum oxide. The position and temperature of the flame are strongly influenced by the aluminum oxide condensation process.
Studies on Relation between Solubilities of Stigmasterol and Non-Stigmasterol prepared from Soysterol

Solubility measurement in organic solvents was applied on stigmasterol, non-stigmasterol and these mixtures. These results are given in tables and figures.Separation of stigmasterol from the sterols mixtures was found difficult by inoculation method.From these data, stigmasterol and non-stigmasterol showed a behavior like a solid solution in crystalline form. However, this behavior could not be confirmed by X-ray powder diffraction method.
Determination of residues of chloramphenicol,thiamphenicol and florfenicol in shrimp by isotope dilution liquid and chromatography tandem mass spectrometry

Objective:The method for the determination of three chloramphicols including chloramphenicol(CAP),thiamphenicol(TAP) and florfenicol(FF) in shrimp was developed by isotope dilution liquid and chromatography tandem Mass Spectrometry(LC-MS/MS). Methods:With chloramphenicol-d5(CAP-d5) as internal standard,samples were extracted with acetonitrile,defatted with hexane,cleaned through LC-Si solid-phase column,eluted with acetone-hexane(6 + 4),evaporated by nitrogen gas to nearly dry. The extract components were separated completely on a Atlantis  T3 column with acetonitrile-water-10mmol. Lammonium acetate for gradient elution and simultaneously quantified by the isotope internal standard under the negative ion mode using multiple reactions monitoring mode. Results:The limits of detection for CAP,TAP and FF were the same as 0. 03μg/kg,and the limit of quantification were 0. 10 μg/kg. The average recoveries of CAP,TAP and FF for spiked blank sample were 82. 0% ~ 99. 3%,73. 5% ~ 85. 6%,76. 0% ~ 98. 5% respectively,and their relative standard deviation varied between 4. 0% and 12. 5%. The method was applied to analyze 90 shrimp samples from Guangdong region,three of which were confirmed to contain CAP,whose concentrations ranged from 1. 0 μg/kg to 4. 3 μg/kg.Conclusion:The method was selective,sensitive,accurate and suitable for deter mination of trace three chloramphicols analysis in shrimp.
Surgical management of diverticular disease.

It is the recognition of the severity and extent of extracolic infection, superimposed upon segmental muscular disease, that challenges clinical judgment as to how best to treat the patient with diverticulitis.
Exploring and Understanding Differences Between Deliberate and Impulsive Male and Female Burglars

Relying on rational choice theory, we compare burglars’ varying levels of offense planning to understand differences among types of burglars. Surveys were collected from a sample of incarcerated male and female burglars in three states. Participants answered questions detailing aspects of a burglary including motivations, target selection, deterrents, and techniques. Comparisons were made between 119 deliberate (32%) and 257 impulsive (68%) burglars. Deliberate burglars focused on obtaining cash, whereas impulsive burglars were more motivated by drug habits. Impulsive burglars were more easily dissuaded from a target when multiple obstacles are present. Burglars consider how many obstacles they may have to overcome, providing support for rational choice-based, situational crime prevention efforts. Differences in burglar motivation emerged and are discussed.
Der ultimative Trip

Es muss meine fruhe Liebe zu Planetarien gewesen sein, die mir den Wunsch eingab, Astronom zu werden.1 Man stelle sich also meine Uberraschung, Emporung und den Unmut vor, den ich empfand, als ich entdeckte, dass Astronomie nicht nur darin bestand, im Dunkeln zu sitzen und fasziniert nach oben in einen Abgrund zu starren. Man musste mathematische Operationen durchfuhren, physikalische Gesetze in Betracht ziehen und schier endlos katalogisieren. Meine Karriere als Naturwissenschaftler hat dieses rude Erwachen nicht uberlebt, das wohl in meinem ersten Jahr am College erfolgte. Da ware ich nun aber doch noch, wie ich mich der Diskussion uber das Science-Fiction-Kino widme und noch immer diesem Erlebnis hingebe, im Dunkeln zu sitzen und in die Unendlichkeit hinauszuspahen.
Scanning Tunneling Microscopy Study of the Interaction between Adsorbed Clusters and Graphite Substrates

In previous studies we have observed ten different superstructures on graphite near platinum clusters using scanning tunneling microscopy. Additional types of such structures were recently found for clusters of cobalt as well. The occurrence of the structures was independent of the size and shape of the clusters. They have the same periodicity as for platinum clusters and can be described by periodic charge-density modulations (PCDM) on the graphite lattice. The PCDM may be explained by surface stress produced by the clusters.
Occupational diversification as an adaptation to rainfall variability in rural India

Occupational diversification among household members in rural India is investigated as an adaptation strategy against the risks arising from the variability of local rainfall. Nationally representative household-level survey data are combined with the coefficient of variation of rainfall constructed based on historical rainfall data at the district level. The analysis finds that high rainfall variability has significant negative effects on the agricultural specialization of within-household occupational choices. This result is reinforced by the finding that improved access to irrigation, education, credit, roads, and postal services, is associated with a lower occupational diversification within families and a greater specialization of household members in agricultural-related employment.
Phase II trial of the combination of ofatumumab and lenalidomide in patients with relapsed chronic lymphocytic leukemia (CLL).

6516^ Background: Based on the activity of ofatumumab and lenalidomide as monotherapy, we evaluated efficacy and tolerability of the combination in pts with relapsed CLL. Methods: Thirty-six pts entered this phase II study. All pts had an indication for therapy, adequate liver/renal function and received prior fludarabine. Ofatumumab IV was given weekly for 4 weeks (300mg w 1; 1,000 mg w 2-4), monthly during months 2-6, and every other month during months 7-24. Lenalidomide 10 mg PO/day started on day 9 and continued for 24 months. Responses were assessed (2008 IWG criteria) at month 3, 6 and every 6 months. Results: Thirty-four pts are evaluable. Median age was 64 yrs (34-82), 59 % of the pts had Rai stage III-IV disease, median β-2M level was 4.1 mg/dL (1.7-16), 62 % of the pts had unmutated IgHV, 26% del(17p) and 12% del(11q). Median number of prior treatments was 2 (1-8), all pts had been treated with FCR and 29% were fludarabine-refractory. The overall response (OR) rate is 65% (22 pts); 7 pts (21%) ...
Robotic Partial Nephrectomy

Robotic-assisted laparoscopic partial nephrectomy in children most commonly involves patients who have a nonfunctioning moiety in a duplex renal system. Specific indications that would lead to discussion with the patient and parents of intervention include recurrent urinary tract infections, flank pain, or nausea/vomiting suspected to be related to the nonfunctioning moiety. Asymptomatic patients raise the concern about the long-term risks of developing symptoms, generally related to infection.
Board Composition and Crisis Management Effectiveness: The Case of Corporate Data Breaches

Despite extensive scholarly work on the antecedents and outcomes of organizational crisis, close research scrutiny on the role leaders play following high profile organizational crises is still evo...
TOPPE: A framework for rapid prototyping of MR pulse sequences.

Purpose To introduce a framework for rapid prototyping of MR pulse sequences. Methods We propose a simple file format, called "TOPPE", for specifying all details of an MR imaging experiment, such as gradient and radiofrequency waveforms and the complete scan loop. In addition, we provide a TOPPE file "interpreter" for GE scanners, which is a binary executable that loads TOPPE files and executes the sequence on the scanner. We also provide MATLAB scripts for reading and writing TOPPE files and previewing the sequence prior to hardware execution. With this setup, the task of the pulse sequence programmer is reduced to creating TOPPE files, eliminating the need for hardware-specific programming. No sequence-specific compilation is necessary; the interpreter only needs to be compiled once (for every scanner software upgrade). We demonstrate TOPPE in three different applications: k-space mapping, non-Cartesian PRESTO whole-brain dynamic imaging, and myelin mapping in the brain using inhomogeneous magnetization transfer. Results We successfully implemented and executed the three example sequences. By simply changing the various TOPPE sequence files, a single binary executable (interpreter) was used to execute several different sequences. Conclusion The TOPPE file format is a complete specification of an MR imaging experiment, based on arbitrary sequences of a (typically small) number of unique modules. Along with the GE interpreter, TOPPE comprises a modular and flexible platform for rapid prototyping of new pulse sequences. Magn Reson Med 79:3128-3134, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Iteratively Reweighted Least Squares Mapping of Quantitative Trait Loci

Mapping quantitative trait loci (QTL) is a typical problem of regression with uncertain independent variables because the genotype of a putative QTL is not observed. Rather, the genotype is inferred from marker information. The method of maximum likelihood (ML) methods is considered to be the optimal solution for this problem because the distribution of the unobserved QTL genotype is fully taken into account. The simple linear regression method (REG) is a first-order approximation to ML and usually performs very well. In this study, an iteratively reweighted least squares method (IRWLS) is proposed. The new method is a second-order approximation to ML because both the expectation and the variance of the unobserved QTL genotype are taken into consideration. The IRWLS is developed in the context of a single large outbred family. The properties of IRWLS are demonstrated and compared with REG and ML via replicated Monte Carlo simulations. The conclusions are: (1) when marker information content is high, the three methods perform equally well, but ML and IRWLS outperform REG when marker information content is low and the variance explained by the QTL is high; (2) when the residual distribution is not normal, ML can fail or have low power to detect small QTLs, but REG and IRWLS are robust to non-normality; and (3) when the residual distribution is normal, the performance of IRWLS is almost identical to ML, but the computational speed of IRWLS is many times faster than that of ML.
The Influence of Pheromones on Puberty in Rodents

This discussion will focus on evidence indicating that the onset of puberty can be influenced by both acceleratory and inhibitory pheromonal stimuli in a variety of species. It is important to understand the factors controlling puberty because it, along with birth and death, are the three most critical events in the life history of an organism. At a fundamental level, the attainment of puberty permits an organismto contribute its genes to the gene-pool of the species, and at a more immediate level, the attainment of puberty results in the addition of another individual to the breeding population of a species. Twenty-five years ago Cole (1954) described the important role of the age of puberty in population dynamics. A slight reduction in the mean age of attaining puberty can markedly enhance the reproductive potential of a population by reducing generation time. Pheromones may be one of several factors playing an important role in regulating puberty.
Epistemic Contrast in Medical and Legal Gender Classifications and their Influences on the Dewey Decimal Classification

Hjorland (2010) writes, “The relative strengths and weaknesses of different [epistemic] approaches are an important research question for the field of KO” (p. 40). Determining who has the authority to speak, along with examining the decisions those authorities make, can reveal the epistemological perspective or perspectives at play. Interrogating the epistemic stance underlying a classification can help understand ontological decision-making process of the institution that claims the classification. In classifying groups of people, formal gender classifications can marginalize people who do not identify with traditional understandings of sex and gender. Sex, or biological characteristics, and gender, the social aspects associated with a particular sex, intertwine, and their characteristics can be conflated. Though in practice both gender and sex possess a great deal of variation and fluidity, most of the world considers them binary or some version of trinary, particularly in formal institutions. Western classification reinforces this rigidity with its principles of mutual exclusivity and hierarchical force. A formal sex or gender classification represents the sanctioned outlook of a particular institution, which then can affect people’s lived experience.
Antiestrophilin Monoclonal Antibodies as Immunocytochemical Probes of Estrogen Receptor in Tissue Sections of Breast Carcinomas

In recent years, it has become apparent that a reliable histochemical technique for the demonstration of estrogen receptor (ER) in tissue sections would be very useful for the evaluation of breast cancer patients. Indeed, the biochemical assays for ER currently used in clinical laboratories, although of proven value, suffer from several limitations (Poulsen, 1981), a very important one being that of sampling. This is especially true for tumors with abundant or unevenly distributed stroma in which the specimen given to the biochemist may not be representative of the tumor as a whole, and for small lesions in which the amount of tissue available is not sufficient for biochemical analysis. The histochemical visualization of ER could obviate some of these limitations and offer the advantage of providing a better appreciation of the topographic distribution of ER in any given tumor and of the percentage of ER-positive carcinoma cells.
An electron microscope study of the dimorphic spermatozoa of Asplanchna (Rotifera). II. The development of "atypical spermatozoa".

1. The examination of the adult Asplanchna testis reveals several different cellular elements, including motile mature spermatozoa, groups of immature cells, possibly representing spermatids, and fusiform rod-like structures sometimes attached to highly specialized but non-motile cells. 2. The latter structures are thought to represent the atypical members of the dimorphic spermatozoa and it is suggested that the rods are produced by a fusion of membrane bounded elements characteristically seen in these cells. The rods may dissociate from the cells which then seem to undergo degenerative changes. 3. The rods are spiraled and contain microtubules longitudinally oriented along the 10–15 micron length of the rod. Their possible role in the mating process is discussed. 4. The typical or motile spermatozoa contain several unusual cytoplasmic organelles, including dense doughnut-shaped bodies and fenestrated bulbs which may be related to mitochondria. 5. There are apparent nuclear changes in the maturation of spermatids but no dramatic condensation or coiling of nuclear material similar to that seen in the spermatozoa of higher animal occurs.
Classification of propagation-invariant space-time wave packets in free space: Theory and experiments

Introducing correlations between the spatial and temporal degrees of freedom of a pulsed optical beam (or wave packet) can profoundly alter its propagation in free space. Indeed, appropriate spatiotemporal spectral correlations can render the wave packet propagation-invariant: the spatial and temporal profiles remain unchanged along the propagation axis. The spatiotemporal spectral locus of any such wave packet lies at the intersection of the light cone with tilted spectral hyperplanes. We investigate $(2+1)\mathrm{D}$ propagation-invariant ``space-time'' light sheets and identify ten classes categorized according to the magnitude and sign of their group velocity and the nature of their spatial spectrum---whether the low spatial frequencies are physically allowed or forbidden according to their compatibility with causal excitation and propagation. We experimentally synthesize and characterize all ten classes using an experimental strategy capable of synthesizing space-time wave packets that incorporate arbitrary spatiotemporal spectral correlations.
Clinical correlates of response to anti-PD-1 (aPD1)-based therapy in patients (pts) with metastatic melanoma (MM).

e21000Background: aPD1, alone or in combination with ipilimumab (IPI), produces durable responses in a subset of MM. Tumor features that correlate with treatment response, including size, number, a...
Beyond Marriage: Continuing Battles for LGBT Rights

The advance of civil rights for LGBTQ people is among the most important political transformations of the last two decades. During that same time the study of LGBTQ politics became an area of signi...
Intelligent Control Framework for Energy Storage Management on MVDC Ship Power System

Modern ships are undergoing a migration to become all electric ships (AES). Due to the nature and complexity of modern ships, MVDC power system has arisen as a viable option due to its economic and weight aspects. MVDC power system can ensure efficient operation of the power sources on the ship, eliminate the need for synchronization among the generators and avoid the use of heavy bulky transformers. However, the successful operation of a MVDC power system requires adequate control algorithm to ensure load-generation balance. Accordingly, this paper proposes a decentralized intelligent control algorithm to control the storage devices on modern ship power systems, considering pulsed loads. The controller is validated through detailed simulations on MATLAB/Simulink and the results showed that the controller could ensure load-generation balance and proper power sharing among the storage devices.
Effect of particle size on catalytic decomposition of hydrogen peroxide by platinum nanocatalysts

Abstract The decomposition of H2O2 to H2O and O2 is a fundamental chemical reaction catalyzed by platinum nanocatalysts. We recently showed that this is a two-step chemical reaction and that the rate of the overall reaction correlates with particle size for platinum samples subjected to heat. However, the mechanism by which particle size affects the rate of this reaction is not understood. We combined atomic-scale characterization of platinum nanocatalysts subjected to various conditions with multi-variate linear analysis of H2O2 decomposition rate data to determine structure-chemistry/activity relations of platinum nanocatalysts in the decomposition of H2O2. Catalyst particle size, determined through Rietveld analysis, ranged from 8.8 nm to 41 nm . Our results show that the effect of particle size on the rate of H2O2 decomposition is caused by a correlation of particle size with surface chemisorbed oxygen abundance – quantified as the fraction of catalyst surface covered with chemisorbed oxygen (θ). Surface θ has a nearly first order effect on the rate of H2O2 decomposition because the oxidation of Pt → Pt(O) is the rate limiting step of the reaction. When the effects of particle size and surface θ are decoupled the effect of particle size becomes trivial. The approach applied in this study provides a valuable methodology that can be used to deconvolute the effect of correlated variables in many other catalytic chemical reactions of scientific and technological interest.
Clinical Outcomes of Foot Infections in Patients Without Diabetes

Abstract The aim of this study was to report clinical outcomes of moderate and severe foot infections in patients without diabetes. Medical records of 88 nondiabetic patients with foot infections treated at a safety net hospital were retrospectively reviewed. Patients were grouped by the presence of soft-tissue infection (STI) or osteomyelitis (OM). The diagnosis of OM was determined by positive bone culture or histopathology. STIs were defined by negative bone biopsy or negative imaging with magnetic resonance imaging or computed tomography/dual-modality radiolabeled white blood cell single-photon emission computed tomography. Patient outcomes were recorded ≤1 year after admission. Eighty-eight nondiabetic patients admitted to our institution for moderate or severe foot infections were included, 45 OM and 43 STI. No differences were noted in patient characteristics except that OM patients had a higher prevalence of neuropathy (66.7% versus 39.5%, p = .02). OM patients required surgery more often (97.8% versus 67.4%, p
Impact of Collateral on Emergency Department Length of Stay in College-Aged Patients

This study evaluated the efficacy of a collaborative intervention between hospitals and universities to decrease the length of stay (LOS) in the Emergency Department (ED) for college students. The hypothesis was that university collateral would decrease LOS in the ED. A retrospective chart review was performed for 834 consults in patients aged 18–25 regarding presence of collateral, disposition, and LOS. Of those hospitalized, LOS in the ED was 15.7 h for students with collateral, 14.6 h for students without collateral, and 19.5 h for unenrolled peers. There was a statistically significant difference in LOS for patients hospitalized in enrolled versus unenrolled patients (t = 2.17, p = 0.031). Of those discharged home, students with collateral, students without collateral, and unenrolled peers spent 9.7 h, 11.6 h, and 13.6 h in the ED respectively. LOS of enrolled versus unenrolled patients discharged home trended towards significance (t = 1.80, p = 0.073), but no significance was found in relation to collateral (t = 1.21,p = 0.23). This study found that college students had decreased LOS in the ED regardless of collateral when compared to unenrolled peers.
School Counselors’ Experiences With the Section 504 Process: “I want to be a strong team member…[not] a case manager”:

In response to a gap in the literature and to inform school counseling practice, we conducted a phenomenological study of school counselors in five states and 10 school districts, examining their e...
Cardiac rehabilitation in patients with peripheral arterial disease after revascularization.

ObjectivesTo evaluate safety, feasibility, and benefit of cardiac rehabilitation (CR) in patients with peripheral arterial disease (PAD) who undergo revascularization.MethodsWe conducted a prospect...
Motivation in Clinical Interventions

Motivation is a multidimensional drive state that serves as a foundation for most clinical interventions, whether they are psychosocial, pharmacotherapeutic, or some combination. An essential element of health behavior change and maintenance of healthy behaviors, motivation is affected by extrinsic factors such as environmental contingencies and internal factors that are established by learning history. Models of Stages of Change and choice behavior help explicate motivation as a construct. Motivational interviewing is a contemporary, prevalent, and evidence-based approach to assessing and enhancing motivation in clients and patients in health care and social service settings.
Abstract 2532: MicroRNA-1205 directly binds to FRYL and suppresses aggressive prostate cancer

High mortality rates of prostate cancer (PCa) are associated with metastatic castration-resistant prostate cancer (mCRPC) due to the maintenance of androgen receptor (AR) signaling despite androgen deprivation therapies (ADTs). Resistance to second generation ADTs leads to the progression to AR-independent neuroendocrine PCa (NEPC), which is observed in nearly 1 in 5 men with mCRPC and is associated with very poor outcome. PCa neuroendocrine differentiation (PCND) is observed in treatment related NEPC, however, this mechanism is poorly understood. Therefore, further understanding of PCND in ADT resistance may prevent poorer outcomes. The 8q24 chromosomal locus is an important prostate cancer (PCa) susceptibility region containing genetic variants associated with increased PCa incidence and aggressiveness. PVT1 is a gene located within this region that encodes microRNA-1205 (miR-1205), whose function is largely unknown. We have previously reported that miR-1205 is underexpressed in a cohort of histologically confirmed PCa tissue obtained from moAA, when compared to normal tissue and is also underexpressed in vitro in CRPC cells, when compared to non-CRPC cells. We also demonstrated that exogenous miR-1205 significantly inhibited tumor volume in CRPC-derived xenograft male NOD/SCID gamma mice, suggesting that miR-1205 is a tumor suppressor. To understand the molecular mechanism of miR-1205, we demonstrated that miR-1205 directly targets Fry-like (FRYL) by performing an RNA pulldown assay. FRYL is predicted to regulate dendritic branching leading to the hypothesis that FRYL plays a role in PCND. To examine miR-1205 regulation of FRYL in PCND in vitro, LNCaP cells were cultured under androgen deprivation conditions for fourteen days. We observed FRYL mRNA overexpresssion and a significant reduction of miR-1205 expression in LNCaP-PCND cells when compared to undifferentiated LNCaP cells. To further determine whether this mechanism drives PCND, miR-1205 was inhibited in RWPE-1 and LNCaP androgen-sensitive cells. As a result, FRYL protein expression was increased along with neuroendocrine marker expression (Neuron specific enolase 2) when compared to cells transfected with a negative control. To determine whether PCND is driven directly through FRYL activity, FRYL was silenced using an siRNA in PC-3 cells (model of NEPC). Interestingly, knockdown of FRYL did not reveal a decrease of neuroendocrine markers, suggesting that miR-1205 may induce PCND independently of FRYL. Further investigation into the role of miR-1205 and FRYL in PCND is required. Further understanding this molecular mechanism may provide novel insights into overcoming ADT resistance in aggressive PCa. Citation Format: Michelle K. Naidoo, Fayola Levine, Xavier Grana, Olorunseun Ogunwobi. MicroRNA-1205 directly binds to FRYL and suppresses aggressive prostate cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2532.
Under-Recognition of Neonatal Acute Kidney Injury and Lack of Follow-Up.

Objective Acute kidney injury (AKI) incidence is 30% in neonatal intensive care units (NICU). AKI is associated with increased mortality and risk of chronic kidney disease (CKD) in children. To assess follow-up and early CKD, we retrospectively reviewed outcomes of Cincinnati Children's Hospital Medical Center (CCHMC) cohort of neonates from the AWAKEN trial (2014). Study Design Data from 81 CCHMC patients were extracted from the AWAKEN dataset. KDIGO (Kidney Disease: Improving Global Outcomes) criteria for serum creatinine (SCr) and urine output (UOP) 6 months of age (defined as: estimated glomerular filtration rate Results Seventy-seven patients had sufficient data to ascertain AKI diagnosis. In total 47 of 77 (61%) were AKI+ by SCr or UOP criteria (20 stage 1, 14 stage 2, 13 stage 3). Four died during their admission and five were removed from CKD analyses due to urologic anomalies. AKI-UOP alone outnumbered AKI-SCr (45 AKI+ vs 5 AKI+ for all stages). 33% of patients had Conclusion AKI is vastly under-recognized in the NICU, especially if based on SCr alone. This leads to insufficient follow-up to ascertain renal sequelae in this high-risk population. Key Points
Sociocultural determinants of health and wealth in historic African Americans.

In this study, we examine the impacts of individual ancestry and socioeconomic status (SES) on health in historic African Americans through bioarchaeological means. We estimate ancestry from dental...
Dynamic Resource Redistribution and Demand Estimation: An Application to Bike Sharing Systems

Shortage of bikes and docks is a common issue in bike sharing systems. To tackle this problem, operators use a fleet of vehicles to redistribute bikes across the network. We propose a model that captures successful user trips in the system, and a new mixed integer programming formulation that solves the dynamic redistribution problem by producing routes and pick-up/drop-off decisions for the vehicles. In order to scale to large instances, we develop a decomposition method based on proper station grouping, accompanied by an optimization with partial information approach, where relevant information for each group (routing and redistribution options) is modeled using piecewise linear concave functions and explicitly included in the model. We test our methods on both synthetic and real-world data, and show that our algorithms can scale to large real-world systems, with short running times that allow for real-time information to be taken into account. Furthermore, since accurate estimation of user demand is essential for efficient redistribution, we also develop data-driven and optimization-based approaches to consider lost and shifted demand. Our methods are general and not tied to the specific application domain; for instance, the optimization with partial information can be applied to any pick-up and delivery vehicle routing problem.
Genetic Characteristics of Influenza A/H3N2 Virus Neuraminidase Gene:A Survey from 2010 to 2012 in Qinghai Province,China

This study aims to perform a survey of genetic variation in neuraminidase(NA)gene of influenza A/H3N2virus,as well as related resistance to NA inhibitors,in Qinghai Province of China,2010to 2012. Strains of influenza A/H3N2isolated during an influenza survey from 2010to 2012in Qinghai were enrolled by random sampling.Viral RNA was extracted and amplified by RT-PCR.Purified PCR products were sequenced thereafter.Genetic analysis of nucleic acid and the derived amino acid sequences was performed by MEGA 4.0.Phylogenetic trees were also constructed.Strains isolated during 2010-2011in this study clustered closely with World Health Organization(WHO)2010-2012reference vaccine strain A/ Perth/16/2009and 2008-2010reference vaccine strain A/Brisbane/10/2007on the phylogenetic tree,while the 2012isolates were located on another branch.In analysis of derived amino acid sequences,the 2010 isolates mutated at K81T,the 2011isolates mutated at I26Vand D127N,while the 2012isolates mutated at E41K,P46A,I58V,T71N,L81P,D93G,D127N,D151N,and I307M.The D151N mutation added a glycosylation site to the activity center of NA.No significant variation was discovered in H3N2NA gene of 2010-2011isolates in Qinghai,China.Isolates of 2012were found with significant mutation,which has the potential of inducing minor resistance to NA inhibitors like zanamivir and oseltamivir.
Technical Aspects of Clinical and Experimental Cerebrospinal Fluid Investigations

In recent years, the physical and chemical examination of cerebrospinal fluid (CSF) has become increasingly important in diagnostic patient evaluations and in both clinical and animal research. The CSF bathes the brain and spinal cord, and thus tends to reflect the state of health and activity of the central nervous system.109 Meaningful interpretation of CSF findings requires relatively sophisticated knowledge of CSF physiology and pathology. It is hoped that this information will be supplied by this multidisciplined volume. The purpose of this chapter is to discuss aspects of protocol formulation that ensure the validity of CSF data. In addition, various clinical and experimental techniques of obtaining ventricular, cisternal, and lumbar CSF will be assessed.
Cyclic Stress-Strain Behavior of Two Alloys at High Temperature

The cyclic stress-strain curve is useful in the design of structural components that are subjected to cyclic plastic deformation. Since the incremental step test has been used successfully to approximate cyclic stress-strain curves of metals at room temperature, the objective of this study is to evaluate its usefulness in describing the cyclic deformation behavior of two alloys at elevated temperature. Constant strain rate incremental step tests were conducted on nickel-iron-chromium Alloy 800 and Type 304 austenitic stainless steel in air at temperatures between 70 and 1400 F. This experimental technique provided a useful method of determining cyclic stress-strain curves for these two alloys over that temperature range. Alloy 800 cyclically hardened by factors between 2 and 5, with a maximum amount of hardening at 1200 F. Type 304 stainless steel cyclically hardened by factors between 2 and 3, with a maximum amount of cyclic hardening at 1000 F. Strain rate and maximum strain range were shown to influence cyclic hardening of the Type 304 stainless steel at both 1000 and 1200 F. Results indicated that the cyclic stress-strain curve obtained from an incremental step test is most useful for estimating the cyclic stress-strain response of a material under variable-amplitude loading.
Cloning, nucleotide sequence, and taxonomic implications of the flagellin gene of Roseburia cecicola.

The gene coding for the flagellin protein of Roseburia cecicola, an oxygen-intolerant, gram-negative, anaerobic bacterium indigenous to the murine cecum, has been cloned and sequenced. NH2-terminal amino acid sequence data from the flagellin protein were used as a basis for the synthesis of two mixed-sequence deoxyoligonucleotides. The oligonucleotides were used to identify and clone the flagellin structural gene. DNA sequence analysis of M13mp8 and mp9 subclones revealed a protein with a length of 293 amino acids and a molecular weight of 31,370. Comparisons with the sequences of flagellins of other species revealed conserved regions and suggested that although R. cecicola has structural characteristics of a gram-negative bacterium, it may be most closely related to the gram-positive bacteria. Images
Natural polyphenols based new therapeutic avenues for advanced biomedical applications

AbstractPolyphenols are naturally occurring, synthetic or semisynthetic organic compounds that offer a vast array of advanced biomedical applications. The mostly researched polyphenolic compounds are resveratrol and flavanols, notably (−)-epicatechin. The ongoing research on clinically important resveratrol and flavanols has revealed their potentials as extremely efficient drug agents that can be leveraged for new therapeutic designs for combating stroke related injuries, cancer and renal failures. Here, we have highlighted recent developments in this area with an emphasis on the biomedical applications of polyphenols. Also, a perspective on the future research directions has been discussed. We believe that this review would facilitate further research and development of polyphenols as a therapeutic avenue in medical science.
Tenfold d-electron degeneracy in the Hubbard model and transition-metal magnetism I. The paramagnetic-ferromagnetic transition

Replacing the simplified s-electron picture of Penn [a] [4], intrasite d–d interactions are included in the Hubbard model. Choosing k-space correlation functions to represent the paramagnetic and ferromagnetic states, the tenfold degenerate eigenvalue problem is solved and free energies are calculated self-consistently for various combinations of the three parameters: bandfilling, direct interaction constant divided by the bandwidth, exchange interaction constant divided by the bandwidth. The paramagnetic-ferromagnetic phase boundary surface is plotted at near zero and finite temperatures with the third dimension being exchange interaction constant divided by the bandwidth. The near-zero-temperature trend shows that the inclusion of exchange, as expected, enhances the ferromagnetic region at the expense of the paramagnetic region. This is exactly opposite to the nondegenerate, t-matrix result of Caron and Kemeny [6]. Finite temperature calculations show the same trend with increasing exchange, but shift the phase boundary surface so as to decrease the ferromagnetic region. Innere d–d-Wechselwirkungen werden in das Hubbard-Nodell einbezogen und damit das vereinfachte s-Elektronenbild von Penn [4] erweitert. Durch die Wahl von Korrelations-funktionen im κ-Raum zur Darstellung der paramagnetischen und ferromagnetischen Zu-stande wird das zehnfach entartete Eigenwertproblem gelost und die freien Energien selbst-konsistent fur verschiedene Kombinationen der drei Parameter Bandfullung, Konstante der auf die Bandbreite bezogenen, direkten Wechselwirkung und Konstante der auf die Bandbreite bezogenen Austauschwechselwirkung berechnet. Die Grenzflache der para-magnetisch-ferromagnetischen Phase in der Nahe des Temperaturnullpunkts und bei end-lichen Temperaturen wird mit der dritten Dimension, der auf die Bandbreite bezogenen Austauschwechselwirkungskonstante dargestellt. Die Temperaturabhangigkeit in der Nahe des Nullpunkts zeigt wie erwartet, das der Einschlus von Austauschwechselwirkung den ferromagnetischen Bereich auf Kosten des paramagnetischen Bereichs ver-grollert. Das ist genau entgegengesetzt dem nichtentarteten t-Matrix-Ergebnis von Caron und Kemeny [6]. Berechnungen fur endliche Temperaturen zeigen denselben Verlauf mit anwachsender Austauschwechselwirkung, verschieben jedoch die Oberflache der Phasen-grenze so, das der ferromagnetisohe Bereich abnimmt.
Aerosol transport in a naturally-convected boundary layer☆

Abstract This paper is addressed to the analysis of aerosol deposition to an isothermal vertical surface through naturally-convected boundary layers. Both laminar and turbulent boundary layers, and condensing and noncondensing systems are considered. The general approach is to utilize a heat-transfer analogy to predict deposition in limiting cases of zero and predominant aerosol diffusion. These limiting results are then combined in an attempt to predict nonlimiting behavior. Comparison with computed results from a more refined boundary-layer analysis of the steam-air system shows reasonable agreement for most situations involving laminar flows. No such comparison is possible for the turbulent regime, owing to the absence of related work in the field. The equations presented herein are suggested for use in engineering estimates and as a means for correlating future related results of an experimental nature.
SHARED DECISION-MAKING RESULTS IN KNOWLEDGE TRANSFER ACROSS DIVERSE PATIENT SUBGROUPS: AN ENCOUNTER-LEVEL META-ANALYSIS OF DECISION AID TRIALS

Shared decision-making with decision aids (DA) improves patient knowledge and reduces decisional conflict. The extent to which they do so across sociodemographic subgroups remains unknown. An encounter-level meta-analysis of five cardiovascular DA randomized trials examined the impact of
In Vitro Activity of Cefepime and Other Broad-Spectrum β-Lactams Tested Against 129 mec A-negative Staphylococcus spp. Isolates: A Multicenter Sample

The in vitro activity of cefepime was compared to that of penicillin, piperacillin/tazobactam, ceftazidime, ceftriaxone, imipenem, vancomycin, and teicoplanin by using the broth microdilution method against 129 isolates of Staphylococcus [50 S. aureus and 79 coagulase-negative staphylococci (CoNS], selected for their lack of the mec A gene as determined by the polymerase chain reaction. These isolates were obtained from a recent (1995-1996) surveillance of nearly 5000 nosocomial blood stream isolates from more than 40 geographically diverse U.S. medical centers. These results were compared to CoNS results from the same collection selected for their phenotypic susceptibility to oxacillin (OS; MIC < or = 2 micrograms/ml) regardless of their med A genotype. Cefepime, as well as piperacillin/ tazobactam, ceftriaxone, and imipenem, showed 100% susceptibility against OS and mec A-negative staphylococci. Ceftazidime showed relative resistance (30.2% resistant) against CoNS classified as OS based on phenotypic characteristics (MIC < or = 2 micrograms/mL) as compared to strains of mec A-negative CoNS (5.1% resistant). Accurate phenotypic detection of mec A-positive staphylococci by simple standardized in vitro susceptibility tests becomes very important to guide empirical use of beta-lactams for therapy. Furthermore, previously published MIC90 and range data for broad-spectrum beta-lactams versus OS have been falsely elevated by the presence of mec A-positive strains. The greater use of these potent beta-lactams against true mec A-negative staphylococci should enhance clinical outcomes and reduce the need for vancomycin.
Developmental aspects of passive and active avoidance learning in rats

In Experiment 1, groups of rats 16, 19, 25, 32, and 90 to 120 days of age, were tested for retention of a passive avoidance response 2 min or 24 hr following a single training trial. Passive avoidance learning improved markedly with age, and retention over a 24-hr interval was complete for all age groups. In Experiment 2, rats 19, 25, 32, and 90 to 120 days of age were trained in a simple, active avoidance task. A trials-to-criterion measure indicated that learning was relatively independent of age, although 19-day rats were somewhat inferior to older rats. The occurrence of differences in passive avoidance learning through developmental ranges in age where simple active avoidance is little affected suggests that inhibition of responding may be selectively influenced by maturational variables.
Synergism between immunoglobulin enhancers and promoters

Enhancers are DNA sequences that stimulate transcription from eukaryotic promoters1–3. This stimulatory effect can be exerted over large distances and from a position either 5′ or 3′ of a promoter. Enhancers have been found in the genomes of many viruses, and in some cellular genes such as those encoding immunoglobulin heavy chain4,5 and κ light chain6,8. An important feature of both viral and cellular enhancers is the ability of each enhancer to stimulate transcription from many promoters other than the one with which it is found associated1,2. However, the question of whether cellular enhancers stimulate their ‘own’ promoter more efficiently than other promoters has apparently not been investigated. We show here that the κ light-chain enhancer stimulates a κ promoter about 20-fold more than it stimulates either the simian virus 40 (SV40) early promoter or a metallo-thionein (MT) promoter, two promoters that are very sensitive to other enhancers. Similarly, the heavy-chain enhancer stimulates a heavy-chain promoter much more than it stimulates the SV40 and MT promoters. This synergism between immunoglobulin enhancers and promoters might be due to the action of a protein that binds specifically to each of the regulatory elements.