cssi/SciSciGPT-SciSciNet huggingface dataset:
Wideband antenna using non-foster loading elements

This paper proposes a different approach to non-Foster or active matching. An antenna structure with two ports is considered. One port is used to couple the signal, while the other one is connected to a non-Foster network. The advantage of this configuration is that the antenna can be designed to have real input impedance, as seen from the feeding port, fairly constant across a very broad band when the active load is applied. The input reactance compensation is essentially performed by the non-Foster network, typically behaving as a negative inductor.
Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth

Alteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant prostate cancer (CRPC). However, how PTEN loss is involved in CRPC development is not clear. Here, we show that castration-resistant growth is an intrinsic property of Pten null prostate cancer (CaP) cells, independent of cancer development stage. PTEN loss suppresses androgen-responsive gene expressions by modulating androgen receptor (AR) transcription factor activity. Conditional deletion of Ar in the epithelium promotes the proliferation of Pten null cancer cells, at least in part, by downregulating the androgen-responsive gene Fkbp5 and preventing PHLPP-mediated AKT inhibition. Our findings identify PI3K and AR pathway crosstalk as a mechanism of CRPC development, with potentially important implications for CaP etiology and therapy.
Guest Editors' Introduction: African American Print Cultures

Toni Morrison’s words in the epigraph above delineate some of the multiple people and practices associated with the production and promotion of a single publication. Her words speak to various and imbricated cultures employed by an author interested in producing and promoting a book, a black book, THE Black Book, directing herself to the majority black readership of Black World magazine. When she wrote “Behind the Making of The Black Book” in 1974, Morrison was working as an editor at Random House, a white-owned publishing house; her metanarrative, then, assures readers that she was mindful about employing the services of a black “production man” and a black printer. Although her exclusion of a racial signifier for the book’s designer could suggest that this person was not black, there is no disputing that she had deliberately involved black professionals in the production of The Black Book and was now reassuring the readers of Black World of that deliberate choice. Morrison’s essay ran under a byline noting that she was a former teacher at Howard University
Nonlinear Weighted Flux Methods for Particle Transport Problems

A new parameterized family of iterative methods for the 1‐D slab geometry transport equation is proposed. The new methods are derived by integrating the transport equation over −1≤μ≤0 and 0≤μ≤1 with weight 1+β|μ|α, where α≥0. The asymptotic diffusion analysis enables us to determine a particular method of this family the solution of which satisfies a good approximation of both the diffusion equation and asymptotic boundary condition in the diffusive regions. Note that none of the α‐weighted nonlinear methods possesses this combination of properties. The convergence properties of the proposed method are similar to the properties of the diffusion‐synthetic acceleration (DSA), quasi‐diffusion, and DSA‐like α‐weighted nonlinear methods. Numerical results are presented to demonstrate the performance of the derived method.
Distribution of Myxobolus scleroperca (Myxobolidae: Myxosporea) in yellow perch (Perca flavescens) in the Great Lakes

Myxobolus scleroperca infected the sclerotic cartilage of 26 of 100 yellow perch (Perca flavescens) examined in August-September 1991 from the Indiana waters of southern Lake Michigan. The mean lengths of infected and uninfected fish were 171 mm and 148 mm, respectively. A significantly higher percentage of female fish were infected than male because more larger females were examined than males. Perch less than 94 mm were not infected, indicating that the parasite is not evenly distributed in the host population, preferring larger (older) fish. An alternative explanation that should be considered is that young fish die from this infection. Yellow perch collected from eastern Lake Michigan in 1990 and from Saginaw Bay, Lake Huron in 1991 were not infected with M. scleroperca, indicating that the parasite has a patchy distribution among perch populations of the Great Lakes.
Perceptions of Voice Teachers Regarding Students' Vocal Behaviors During Singing and Speaking

Summary Objective This study examined voice teachers' perceptions of their instruction of healthy singing and speaking voice techniques. Methods An online, researcher-generated questionnaire based on the McClosky technique was administered to college/university voice teachers listed as members in the 2012–2013 College Music Society directory. Results A majority of participants believed there to be a relationship between the health of the singing voice and the health of the speaking voice. Participants' perception scores were the most positive for variable MBSi, the monitoring of students' vocal behaviors during singing. Perception scores for variable TVB, the teaching of healthy vocal behaviors, and variable MBSp, the monitoring of students' vocal behaviors while speaking, ranked second and third, respectively. Perception scores for variable TVB were primarily associated with participants' familiarity with voice rehabilitation techniques, gender, and familiarity with the McClosky technique. Perception scores for variable MBSi were primarily associated with participants' familiarity with voice rehabilitation techniques, gender, type of student taught, and instruction of a student with a voice disorder. Perception scores for variable MBSp were correlated with the greatest number of characteristics, including participants' familiarity with voice rehabilitation techniques, familiarity with the McClosky technique, type of student taught, years of teaching experience, and instruction of a student with a voice disorder. Conclusion Voice teachers are purportedly working with injured voices and attempting to include vocal health in their instruction. Although a voice teacher is not obligated to pursue further rehabilitative training, the current study revealed a positive relationship between familiarity with specific rehabilitation techniques and vocal health.
Avoiding Litigation for Product Instructions and Warnings

The plaintiff suing for injuries arising from a product with allegedly defective instructions or warnings has the burden of proving each of the elements for every cause of action asserted, while the defendant prevails by defeating just one element for each cause of action. Technical communicators can increase their legal literacy by learning the elements that are most easily defeated and thereby avoid subjecting their product instructions and warnings to litigation. This article surveys the existing scholarship to show the need for more attention to legal terms, theory, and practice before explaining how lawyers approach litigation. The article then turns to each of the main causes of action—the functional approach of the Restatement (Third) of Torts: Products Liability, negligence, and breach of express warranty and misrepresentation—with an emphasis upon the elements that are most within the control of the technical communicator.
Multicenter survey analysis of satisfaction according to actual utilization of rehabilitation services

[Purpose] Most such studies have been limited to evaluating the muscle activity patterns of lower extremity muscles using surface electromyograms, but studies of muscle activity patterns according to chair types are lacking. [Subjects and Methods] In the present study, 52 university students in their 20s (26 males, 26 females) were selected in order to analyze the activity of five lower extremity muscles (vastus lateralis, rectus femoris, vastus medialis, tibialis anterior, and gastrocnemius). The selected subjects had sufficient muscle strength for the experiment and normal joint range of motion. [Results] To examine the sociodemographic variables of the study subjects, the frequencies and percentages of individual items were presented as follows Table 3. [Conclusion] Differences in lower extremity muscle activity levels during standing and sitting were identified, and differences between genders were also seen. There was no significant difference in lower extremity muscle activity levels between use of fixed and wheeled chairs.
Molecular Recognition of tRNA Species using Solid-State Nanopores

Intracellular RNA molecules adopt a wide variety of 3D structures, many of which have been studied using high-resolution structural techniques such as X-ray crystallography and NMR. However, while canonical structural features for a class of RNA molecules are assumed based on such studies, structural variations within a class are extremely difficult to detect, as only a limited set of structures are available. For example, the number of unique transfer-RNA (tRNA) molecules in eukaryotes can be ∼100, not including variant products of post-transcriptional modification. It has been hypothesized that tRNA accommodation in the ribosome during translation is modulated by tRNA stiffness, which in turn affects the translation kinetics. Despite this, no experimental studies that probe tRNA stiffness are available. In this work, we electrophoretically drive individual tRNA molecules through ∼3nm diameter pores in order to study their deformation kinetics during translocation. Surprisingly, we find that all six tRNAs studied here exhibit unique translocation kinetics, which we believe correspond to variations in their mechanical properties. Implementation of machine learning algorithms reveal a multidimensional set of parameters that can be used to ascertain the identity of a tRNA from a single ionic current pulse with 70-90% accuracy. Our results pave the way for a deeper understanding of RNA tertiary structure and its dependence on post-transcriptional modifications.
Adolescent mental health case management: Provider perspectives

ABSTRACTDue to the inconsistent definitions and varying models of implementation of adolescent mental health case management, the perceptions and experiences of the professionals providing services are invaluable to improving case management and mental health outcomes for adolescents. This qualitative article examines case management as a service for adolescents with mental illness within the context of one Midwestern state. The primary research question was: what are the current experiences of professionals providing case management services to adolescents with mental illness? Through collaboration with community mental health centers, researchers conducted five focus groups with adolescent mental health providers. Focus group participants discussed the challenges they currently experience while providing services to adolescents, and described current case management practices. Participants also provided suggestions for service delivery improvement. Researchers present focus group results and discuss the...
Chemical studies in experimental scorbutus in cortisone-treated guinea pigs.

Summary1. Sera of guinea pigs suffering from uncomplicated scurvy and sera of scorbutic guinea pigs where cortisone was administered, do not differ from one another as regards the following values: mucoprotein determined as a) tyrosine; b) glucosamine. 2. Sera of scorbutic guinea pigs recovering from the deficiency through the administration of ascorbic acid approach normal mucoprotein tyrosine values more rapidly when cortisone is administered concurrently with ascorbic acid. 3. The administration of cortisone elevates the already high cholesterol and lecithin values in scorbutic guinea pigs.
Igniting the Fire Within Marginalized Youth The Role of Critical Civic Inquiry in Fostering Ethnic Identity and Civic Self-Efficacy

Critical Civic Inquiry (CCI) is a transformative student voice initiative that engages students in critical conversations about educational equity and inquiry-based learning to increase student voi...
Heritage amid an urban crisis: Historic preservation in Cleveland, Ohio's Slavic Village neighborhood

Abstract Cleveland, Ohio's Slavic Village is a shrinking neighborhood within a shrinking city that, in recent years, garnered national attention as an epicenter of the foreclosure crisis. High vacancy rates, deferred maintenance, vandalism, and low market-values present challenges to neighborhood leaders and policymakers. While demolition has dominated policy discourses in shrinking cities, Slavic Village's built environment is the tangible manifestation of the community's rich working-class and immigrant heritage. Thus, this research asks: In an era of urban shrinkage, what role do heritage and historic preservation play in stabilizing or revitalizing shrinking neighborhoods? Drawing on a qualitative case study of Slavic Village, the findings show that neighborhood leaders value heritage, yet historic fabric is in peril as traditional preservation regulations and incentives are insufficient given the scale of devastation. For historic preservation to retain relevance in places like Slavic Village, the profession needs to consider new, creative, even radical approaches that respond to the challenges of urban shrinkage.
Low Molecular Weight GTP-binding Proteins Associated with the Membranes Involved in Post-Golgi Transport of Rhodopsin

Newly synthesized rhodopsin is sorted to the rod outer segment (ROS) of frog rod photoreceptor cells by a population of post-Golgi vesicles which have a relatively simple protein content (Deretic and Papermaster, 1991). In addition to rhodopsin, several low molecular weight (21–25 KD) GTP-binding proteins can be identified on these membranes by α 32P GTP overlays. We have compared the GTP-binding protein content of the retinal post-Golgi vesicle fraction to the content of the Golgi enriched and ROS fractions in order to follow changes in the GTP-binding protein content of these membranes as they mature. Comparison by isoelectric focusing/SDS 2D gel blots (Figure 1) shows that specific GTP-binding proteins are enriched in each fraction, while several proteins are common to all fractions.
Inaccuracy Mapping of 2-D Surfaces for Robot Off-Line Programming

While ihe repeatability of a given robot can be determincd and bounded, ihe accuracy of ihe same robot will vary with spatial position and oricnialion and is difficult (o measure. Not knowing the accuracy of a given robot greatly limits thc flexibility of using robotic workcells and limits the usc of off-linc programming in planning workccU tasks. By using sensor Systems to capture robot to part relative geometry information it is possible to map the inaccuracy of a robot in a localized area. Using such error mapping tcchniques eliminates the need to define the accuracy of the robot in global terms.
“They make money off of us”: a phenomenological analysis of consumer perceptions of corruption in Kenya’s HIV response system

Problems with misallocation and redirection of critical resources and benefits intended for PLHIV are not uncommon in Kenya. This study explores corruption in Kenya’s HIV response system and the implications for health outcomes from the perspective of people living with HIV (PLHIV). Although they might not be directly responsible for health care fund management, PLHIV and their advocacy efforts have been central to the development of HIV system response and they have a vested interest in ensuring proper governance. This phenomenological study was conducted in 2012 in Kiambu County in Kenya. The study was designed to capture the experiences of a select group of individuals living with HIV and AIDS and subsequent effects on intergenerational wealth transmission. Four focus groups were conducted with self-convened HIV/AIDS peer support groups. Findings related to corruption emerged unexpectedly, albeit consistently, across all four focus groups. To validate core themes within the data, including corruption, two coders independently reviewed and coded the data. Participants described incidences of resource misallocation, theft, and denial of services across three thematic levels namely at the interpersonal, provider, and institutional levels. Participants described the negative influence of corruption on their health and financial well-being, and propose: (1) strengthening legal protections for assets belonging to PLHIV, (2) direct representation of PLHIV within service agencies, (3) and addressing information asymmetries to inject transparency into the response system. Our findings add to the growing literature that identifies advocacy among individuals and families impacted by HIV and AIDS to be a useful tool in drawing attention to harmful practices in the HIV response infrastructure; consistent with this movement, communities in Kenya demand greater control over programmatic interventions both at the national and local levels.
Modulation of complex multitask performance by tDCS depends on individual differences in baseline task ability

The ability to multitask is central to many important occupations. Individual differences in multitasking ability have been linked with differential activation within the prefrontal cortex (PFC), but causal evidence is lacking. In this study we applied transcranial direct current stimulation (tDCS) to the PFC during performance of the dual-task videogame Warship Commander (WSC). For low performers- cathodal stimulation, regardless of hemisphere, decreased performance in a subtask of WSC during stimulation, with effects persisting 24hours later. Anodal stimulation to right PFC also decreased performance in the same subtask, but this effect was limited to performance during stimulation. Stimulation did not significantly affect performance for high performers. The results of this study are the first to provide causal evidence for differential recruitment of the PFC for low and high performers. These findings indicate the need for assessment of individual differences in development of cognitive interventions ...
Identitätsphilosophie and the Sensibility that Understands

ABSTRACTMany contemporary scholars argue that Schelling’s version of intellectual intuition retains certain central features of the Kantian and Fichtean conceptions. One of the common claims is that, as with Kant and Fichte, Schelling’s intellectual intuition is the power of the subject’s productive understanding. However, we show that for the Schelling of the Identitatsphilosophie period, intellectual intuition is the power not of an understanding that intuits, or a productive intellect, but of a receptive and penetrating sensibility that understands.
Nontraditional Cardiovascular Risk Factors in Pediatric Type 1 Diabetes

Schizophrenia is a chronic and debilitating brain disorder. It is associated with increased mortality, primarily due to elevated cardio-metabolic risk. Affected patients have higher rates of obesity, metabolic syndrome and diabetes [1]. Intrinsic factors contributing to this increased risk include a shared underlying pathophysiology between schizophrenia and diabetes mellitus involving stress, inflammation and genetics. Extrinsic contributing factors include diet, lifestyle, health care access, low socioeconomic status and overburden of traditional diabetes risk factors. Antipsychotics are associated with an increased risk of obesity, metabolic syndrome and diabetes mellitus [1]. Appetite-regulating hormones, pharmacodynamics and alterations in glucose metabolism may underlie the negative effect of these medications. Reduction in diabetes risk is achieved by mitigating traditional risk factors. Non-pharmacologic and pharmacologic approaches to cardio-metabolic risk reduction may be helpful in these patients.
Current Developments in Fundamental and Applied Aspects of Meat Color

The cherry-red color of retail fresh meats is a major quality influencing the purchase decisions. A multitude of endogenous and exogenous factors influence the redox biochemistry of myoglobin in postmortem skeletal muscles. Current research indicates that the interinfluential interactions between myoglobin, mitochondria, and biomolecules govern meat color stability in muscle-, species-, and packaging-specific manner. Advances in bioanalytical techniques enable characterizing the fundamental mechanisms of these biomolecular interactions, which in turn are exploited to develop innovative preharvest and postharvest strategies to improve the meat color stability.
Fatigue and physical functioning in children with multiple sclerosis and acute disseminated encephalomyelitis.

Background and Objective:Fatigue and physical impairments are a major concern in children with multiple sclerosis (MS) and after acute disseminated encephalomyelitis (post-ADEM). We here aimed to evaluate the interaction between fatigue, exercise capacity, motor performance, neurological status, and quality of life (HRQoL).Methods:In this cross-sectional study, data of 38 children (MS n = 22, post-ADEM n = 16), aged 4–17 years attending our national pediatric MS center, were studied. Fatigue was measured with the Pediatric Quality of Life Multidimensional Fatigue Scale, exercise capacity with the Bruce Protocol, motor performance with the Movement Assessment Battery for Children second edition, HRQoL with the Pediatric Quality of Life Questionnaire, and extent of disability with the Expanded Disability Status Scale (EDSS).Results:Children with MS and post-ADEM experienced more fatigue (p < 0.001), reduced exercise capacity (p < 0.001), and impaired motor performance (p < 0.001), despite low scores on the ...
Dockground: A comprehensive data resource for modeling of protein complexes

Characterization of life processes at the molecular level requires structural details of protein interactions. The number of experimentally determined structures of protein-protein complexes accounts only for a fraction of known protein interactions. This gap in structural description of the interactome has to be bridged by modeling. An essential part of the development of structural modeling/docking techniques for protein interactions is databases of protein-protein complexes. They are necessary for studying protein interfaces, providing a knowledge base for docking algorithms, and developing intermolecular potentials, search procedures, and scoring functions. Development of protein-protein docking techniques requires thorough benchmarking of different parts of the docking protocols on carefully curated sets of protein-protein complexes. We present a comprehensive description of the Dockground resource (http://dockground.compbio.ku.edu) for structural modeling of protein interactions, including previously unpublished unbound docking benchmark set 4, and the X-ray docking decoy set 2. The resource offers a variety of interconnected datasets of protein-protein complexes and other data for the development and testing of different aspects of protein docking methodologies. Based on protein-protein complexes extracted from the PDB biounit files, Dockground offers sets of X-ray unbound, simulated unbound, model, and docking decoy structures. All datasets are freely available for download, as a whole or selecting specific structures, through a user-friendly interface on one integrated website.
Multi-omics analysis of the healthy smoker airway reveals smoking related impacts on the lung microenvironment

Background: Smoking remains a global health problem and often leads to the development of lung disease, yet the effects of smoking on the lower airway microenvironment are not fully understood. Aims: We utilized a multi-omic approach to study the interconnectivity of the lower airway bacteriome, virome and metabolome in healthy smokers and nonsmokers. Methods: Bronchoalveolar lavage fluid (BALF) was collected from 30 healthy subjects (20 smokers and 10 nonsmokers). DNA was extracted from BALF supernatant and analyzed via high-throughput sequencing of bacterial 16S rRNA gene amplicons (bacteriome) or random-primed shotgun libraries (virome). BAL cells, cytokines and metabolites were analyzed with fluorescence-activated cell sorting, Luminex, or GC-TOF metabolomics, respectively. Ecological analyses were performed in R. Results: As previously shown, smoking resulted in significant changes in the lung virome but not the bacteriome. Significant differences between healthy smokers and nonsmokers were also noted in several metabolites and cytokines. A subset of BALF cells, cytokines and metabolites, including IL-8 and arachidonic acid (Fig 1B, 1C), were associated with separation of viral communities between smokers and nonsmokers (Fig 1A). Conclusions: Smoking leads to distinct changes in the lower airway microenvironment, including associated changes in the virome and metabolome.
Self-Definition in the Constitution of Faith and Family

In recent years, family law has moved steadily toward a broader conception of family. In the areas of cohabitation, marriage, child custody, and adoption, legislatures and courts have grown more deferential to individual constructions of family life, even if those constructions are quite non-traditional. For the most part, however that generosity has not carried over to the context in which the definition carries the most weight. In the constitutional law of family privacy, courts have tended to adhere to a much narrower and more traditional understanding of what counts as "family." That family should be understood so restrictively under the Constitution, however, is not self-evident. Indeed, in the context of the First Amendment, it is now accepted that religious pluralism demands that religion be understood broadly. Yet, the growing diversity of families has not yet generated a similiar consensus. This article evaluates possible explanations for the differences in the constitutional approach to defining religion and family, including family privacy's status as an unenumerated right and distinctions in the values underlying the respective constitutional guarantees, and concludes that none justifies the full scale of divergence. In fact, the difference in definitional approach ultimately masks a broader similarity in the Supreme Court's protection of family and religious liberties: in both contexts, the Court has used different strategies for grappling with a common dilemma - the need to balance respect for individualism in a realm of profound personal importance with the practical exigencies of communal governance. By pairing greater deference to self-definition of family and religion with an abandonment in both contexts of the pretense of absolutist judicial protection, however, the Court could take account of the core dilemma while remaining more faithful to the underlying constitutional values.
The Use of Confidence Profiles to Assess Tissue-Type Plasminogen Activator

In the last two-and-one-half decades, thrombolytic agents have been developed to dissolve clots from coronary arteries. One of the most recent is tissue-type plasminogen activator (t-PA). At present there are several unanswered questions about the effectiveness of t-PA and its appropriate use in the treatment of MI. It has not yet been approved by the Food and Drug Administration (FDA), recommended for Medicare coverage by the Office of Health Technology Assessment, or recommended for coverage by the Blue Cross and Blue Shield Association. On the other hand, there is evidence and a strong consensus among cardiologists that t-PA is more effective than other thrombolytic agents, including streptokinase (SK) and urokinase (UK), which are approved by the FDA, and at least one third-party payer, Blue Shield of California, has approved t-PA in centers with the necessary expertise. Researchers widely assume that t-PA by itself reduces long-term mortality from MI and are already moving to a new stage of research, in which t-PA is coupled with PTCA.
Obesity among Children and Adolescents

American men are among the most obese in the world (Keyes, Araranis, Blackburn, Van Buchen, Buzina, Djorojevic, Fidanza, Karrone, Menotti, Puddu, & Taylor, 1972), and the same is probably true of American children (Bray, 1976; Osancova & Hejda, 1975). When faced with such statements, two questions come to mind: (1) Does it matter? (or, more colloquially, “So what?”); and (2) Can we do anything about it?
Machine Intelligence in Healthcare and Medical Cyber Physical Systems: A Survey

Today, the US healthcare industry alone can save $300 B per year by using machine intelligence to analyze a rich set of existing medical data; results from these analyses can lead to breakthroughs such as more accurate medical diagnoses, discovery of new cures for diseases, and cost savings in the patient admission process at healthcare organizations. Because healthcare applications intrinsically imply a vast amount of data, the execution of any algorithm on medical data is computationally intensive. Significant advancements made in computational power in the past decade have provided the opportunity for many researchers to successfully implement various machine intelligence-based healthcare applications, which didn’t run efficiently on earlier computational platforms. In this paper, we provide a survey of machine intelligence algorithms within the context of healthcare applications; our survey includes a comprehensive list of the most commonly used computational models and algorithms. We view the application of these algorithms in multiple steps, namely, data acquisition, feature extraction, and aggregation, modeling, algorithm training, and algorithm execution and provide details—as well as representative case studies—for each step. We provide a set of metrics that are used to evaluate modeling and algorithmic performance, which facilitate the comparison of the presented models and algorithms. Medical cyber-physical systems are presented as an emerging application case study of machine intelligence in healthcare. We conclude our paper by providing a list of opportunities and challenges for incorporating machine intelligence in healthcare applications and provide an extensive list of tools and databases to help other researchers.
Assessing Educational Outcomes: Another Hurdle in the Accreditation Process

Universities and colleges that have aviation programs have a unique mission; such programs have a primary purpose of providing graduates for productive careers in aviation and aerospace. In addition, many if not most programs are approved by the Federal Aviation Administration (FAA) and are specifically taught to meet performance objectives contained in the appropriate Federal Aviation Regulations (FARs). But meeting such performance objectives may not be sufficient to meet the future demands of regional accreditation agencies. This paper is an overview of the institutional effectiveness movement, preparing for an accreditation visit, academic change, assisting faculty members to prepare performance objectives, and integrating academic programs that embrace the FARs, the academic traditions of the aviation program, and the unique and highly technical background of the faculty.
QMC-SW: A simple workflow for quantum Monte Carlo calculations in chemistry

Abstract With constant improvements in the speed of computers, the importance of Quantum Monte Carlo (QMC) in chemistry is destined to increase substantially in the next decades, for both benchmark and routine calculations. The accessibility of QMC methods, however, is currently limited by the unintuitive requirements to run most modern QMC codes, and by their sometimes-complicated connections with pre-existing quantum chemistry codes. We present QMC-SW, a Quantum Monte Carlo Snakemake Workflow that automates QMC calculations using the CASINO program, with trial wave functions generated by popular quantum chemistry software, such as ORCA and Q-Chem. A validation of the workflow is also presented, using calculations on atomic and molecular systems.
Prediction of ecological impact of two alien gobiids in habitat structures of differing complexity

Rapid expansion of round goby (Neogobius melanostomus) and western tubenose goby (Proterorhinus semilunaris) beyond their native ranges calls for urgent management action, particularly in localitie...
Rapid Detection of Methicillin-Resistant Staphylococcus aureus in BAL: A Pilot Randomized Controlled Trial.

Background Guidelines recommend empirical vancomycin or linezolid for patients with suspected pneumonia at risk for methicillin-resistant Staphylococcus aureus (MRSA). Unneeded vancomycin or linezolid use may unnecessarily alter host flora and expose patients to toxicity. We therefore sought to determine if rapid testing for MRSA in BAL can safely decrease use of vancomycin or linezolid for suspected MRSA pneumonia. Methods Operating characteristics of the assay were initially validated against culture on residual BAL. A prospective, unblinded, randomized clinical trial to assess the effect of antibiotic management made on the basis of rapid diagnostic testing (RDT) compared with usual care was subsequently conducted, with primary outcome of duration of vancomycin or linezolid administration. Secondary end points focused on safety. Results Sensitivity of RPCR was 95.7%, with a negative likelihood ratio of 0.04 for MRSA. The clinical trial randomized 45 patients: 22 to antibiotic management made on the basis of RDT and 23 to usual care. Duration of vancomycin or linezolid administration was significantly reduced in the intervention group (32 h [interquartile range, 22-48] vs 72 h [interquartile range, 50-113], P Conclusions A highly sensitive BAL RDT for MRSA significantly reduced use of vancomycin and linezolid in ventilated patients with suspected pneumonia. Management made on the basis of RDT had no adverse effects, with a trend to lower hospital mortality. Trial Registry ClinicalTrials.gov; No. NCT02660554; URL: www.clinicaltrials.gov.
Accurate and Efficient Mapping of the Cross-Linked microRNA-mRNA Duplex Reads.

Summary MicroRNA (miRNA) trans-regulates the stability of many mRNAs and controls their expression levels. Reconstruction of the miRNA-mRNA interactome is key to the understanding of the miRNA regulatory network and related biological processes. However, existing miRNA target prediction methods are limited to canonical miRNA-mRNA interactions and have high false prediction rates. Other experimental methods are low throughput and cannot be used to probe genome-wide interactions. To address this challenge, the Cross-linking Ligation and Sequencing of Hybrids (CLASH) technology was developed for high-throughput probing of transcriptome-wide microRNA-mRNA interactions in vivo. The mapping of duplex reads, chimeras of two ultra-short RNA strands, poses computational challenges to current mapping and alignment methods. To address this issue, we developed CLAN (CrossLinked reads ANalysis toolkit). CLAN generated a comparable mapping of singular reads to other tools, and significantly outperformed in mapping simulated and real CLASH duplex reads, offering a potential application to other next-generation sequencing-based duplex-read-generating technologies.
Seeing the Forest for the Trees: A Bibliometric Analysis of Environmental and Resource Sociology

Environmental sociology and the sociology of natural resources have become two established research areas in the United States with distinct institutional origins, research themes, and theoretical ...
Ex vivo expansion of tumor-draining lymph node cells using compounds which activate intracellular signal transduction. II. Cytokine production and in vivo efficacy of glioma-sensitized lymphocytes

We have investigated the anti-tumor activity of ex vivo activated and expanded T cells which had been sensitized in vivo to one of two different syngeneic rat glioma cell lines; D74 or RT-2. Rats were sensitized by inoculation of irradiated tumor cells into each hind foot pad. After 10 days, the tumor-draining lymph node (DLN) from each popliteal region was excised and prepared as a single cell suspension. Tumor-DLN lymphocytes were next activated overnight in RPMI-1640 medium containing 10% fetal bovine serum (FBS), Bryostatin-1 (5 nM), ionomycin (1 μM), and 20 U human recombinant interleukin-2 (IL-2) per ml. Culture for seven days in RPMI-1640 supplemented with FBS and IL-2 resultedin approximately 100-fold expansion of the lymphocyte population. Both D74- and RT-2-sensitized T cells constitutively secreted tumor necrosis factor-α, and both lymphocyte populations produced comparable amounts of the cytokine when co-cultured with either gliomacell line. Neither D74- and RT-2-sensitized effectors constitutively secreted γ-interferon (γ-IFN), but both populations produced γ-IFN when exposed to either glioma cell line in vitro. D74-sensitized T cells released significantly more γ-IFN than the RT-2 DLN lymphocytes. In vitro 51Chromium-release assays indicated that RT-2-sensitized T cells were more cytotoxic for RT-2 targetsthan for the D74 line and that D74-sensitized effectors werealso more cytotoxic for RT-2 targets. To assess in vivo therapeutic efficacy, rats who had been inoculated intradermally with RT-2 cells three days earlier received an intravenous injection of RT-2- or D74-sensitized DLN cells (106Q cells/gram body weight) expanded after activation with Bryostatin-1 and ionomycin or an equal number of lymphokine-activated killer (LAK) cells. Tumordiameters were measured daily and revealed that injection of glioma- sensitized lymphocytes led to the elimination of tumor while treatmentwith LAK cells had no therapeutic benefit. These results indicate, that at least for these two glioma lines, γ-IFN release, rather than in vitro cytotoxicity, was a better predictor for in vivo immunotherapeutic efficacy of the glioma-sensitized, expanded T cells.
Weakly supervised learning of point-level annotation for coral image segmentation

Successful methods for image segmentation typically are based on a large number of annotated data sets. However, these large amount of good quality labels are highly expensive and tedious to obtain especially for marine plants data sets like corals. Therefore, the deficiency of labels is one of the main obstacles to image segmentation. To alleviate this problem, we propose a novel framework that generates labels iteratively only given a few point-level labels taken advantage of the local structure of real images. In our framework, we first train a Convolutional Neural Network (CNN) with initial sparse point-level labeled pixels, and then we use Latent Dirichlet Allocation (LDA) to generate labels based on the features extracted by CNN models, add these generated labels in the training set and train the CNN model again. Thus, our framework relies only on sparsely point-level labels and does not require any extra annotations. Experimental results on coral image data set collected in Pulley Ridge region from the Gulf of Mexico show that our iterative label augmentation method outperforms previous models trained by the same level of supervision.
Innovative Methodology for Short Circuit Failure Localization by OBIRCH Analysis

Lock-in thermography (LIT) is a commonly used FA technique to perform fault isolation for parametric short failures in microelectronic devices as compared with Optical Beam Induced Resistance Change (OBIRCH). This is because the OBIRCH technique becomes significantly less sensitive for direct hard short circuit parametric failure. This paper presents a simple yet innovative and effective methodology to increase resistance variances during OBIRCH analysis in hard short failures to improve the fault isolation success rate.
A Colonial Tentweb Orbweaver Cyrtophora citricola

Few species of spiders can be considered truly social, but a greater number of species, particularly web-building spiders, live in close proximity to one another. One species which has become highly successful through a lifestyle of colonial aggregation is the orbweaver Cyrtophora citricola Forskal. This 6-page fact sheet was written by Lionel A. Stange, and published by the UF Department of Entomology and Nematology, October 2012. http://edis.ifas.ufl.edu/in966
An endocannabinoid catabolic enzyme FAAH and its paralogs in an early land plant reveal evolutionary and functional relationship with eukaryotic orthologs

Endocannabinoids were known to exist only among Animalia but recent report of their occurrence in early land plants prompted us to study its function and metabolism. In mammals, anandamide, as an endocannabinoid ligand, mediates several neurological and physiological processes, which are terminated by fatty acid amide hydrolase (FAAH). We identified nine orthologs of FAAH in the moss Physcomitrella patens (PpFAAH1 to PpFAAH9) with amidase signature and catalytic triad. The optimal amidase activity for PpFAAH1 was at 37 °C and pH 8.0, with higher specificity to anandamide. Further, the phylogeny and predicted structural analyses of the nine paralogs revealed that PpFAAH1 to PpFAAH4 were closely related to plant FAAH while PpFAAH6 to PpFAAH9 were to the rat FAAH, categorized based on the membrane binding cap, membrane access channel and substrate binding pocket. We also identified that a true ‘dynamic paddle’ that is responsible for tighter regulation of FAAH is recent in vertebrates and absent or not fully emerged in plants and non-vertebrates. These data reveal evolutionary and functional relationship among eukaryotic FAAH orthologs and features that contribute to versatility and tighter regulation of FAAH. Future studies will utilize FAAH mutants of moss to elucidate the role of anandamide in early land plants.
Controlled Strain of Cardiac Microtissue via Magnetic Actuation

This work presents a microscale tissue testbed with closed loop mechanical control. The platform leverages a non-contact technique capable of simultaneous actuation and detection, both derived from magnetic fields. We demonstrate cyclic tension and compression of engineered microtissue as well as long-term monitoring of spontaneous beating inside an incubator. The device is capable of positional feedback with high spatial and temporal resolution, while maintaining optical access from a standard microscope. Such a platform will enable experimental design of arbitrary mechanical environments for tissue conditioning, maturation, and monitoring.
Chapter Three – Mud Pumps

Publisher Summary This chapter presents theory and procedures for selecting mud pumps. The selected mud pump should be capable of providing mud flow rates that are high enough to transport drill cuttings to the surface at all stages of drilling. Mud properties that influence the type of pump include mud weight and rheological properties. For Newtonian fluids, viscosity is the only parameter describing fluid rheological characteristics. Plastic viscosity and yield point are the two parameters used to describe the rheological characteristics of Bingham plastic fluids. The minimum required mud flow rate from the mud pump is equal to the minimum required mud velocity times the maximum possible cross-sectional area of annular space during drilling. The minimum required mud flow rate demanded by the borehole geometry from the mud pump is estimated based on the minimum required mud velocity, which should be higher than the drill cuttings slip velocity. The selected mud pump should also be capable of providing pressure that is strong enough to overcome the total pressure loss and pressure drop at the bit in the circulating system at the total hole depth.
A resident’s reflections on queerness and countertransference in emergency psychiatry

This article provides a psychiatry resident's reflections on repeated interactions with a patient in the emergency department. Beginning with an overview of the clinical scenario of a 36-year-old t...
Crossed wires and crooked calls: Imagining the telephone in South Indian comedy films of the 1990s:

In this article, I argue for the necessity of studying the portrayal of technological infrastructures in popular cinema. Cinema provided a venue within which the potentialities of technological inf...
The authors reply: Shared appointments can be good care

Shared appointments are not for everybody, but we have found they help in providing access for hopelessly backlogged physicians and are usually enjoyable for both the patients and the physician.
“I Needed to Aim Higher:” Former Foster Youths’ Pathways to College Success

Although former foster youth desire to pursue higher education, childhood trauma and educational instability, among other experiences, contribute to low college enrollment and completion rates. Through the lens of the ecological systems model, the researchers sought to understand the internal and external factors that former foster youth believe have contributed to or impeded their choices to attend and ability to navigate college. Twenty-three former foster youth currently enrolled in a college or university participated in semi-structured interviews that asked them to explain influences on their preparation for pursuing higher education, their decisions to attend college, and their ability to navigate college life successfully. Findings indicated that youth relied on caregivers, high school counselors, social workers, and child welfare staff who prepared them for college and helped make decisions to apply. They also reported internal motivations to attend college. In college, they relied on campus resources (e.g., extra-curricular activities, faculty) to navigate college life. They reported lingering family problems, lack of family support, and racial/ethnic stereotyping on campus that impacted their college experiences. Their stress was managed by seeking counseling and increasing their campus involvement. Implications suggest that supportive resources should be holistic and include pre- and post-college enrollment academic guidance, family and fictive kin support, positive peer relationships, child welfare agency support, and elimination of social stigmas that can undermine youths’ sense of self-efficacy and future. With increased awareness of needs, colleges or universities and professionals will be better equipped to implement targeted supports for this unique, non-traditional population.
Antireflection temporal coatings: comment

The quarter-wavelength matching technique is widely used because it minimizes the reflection while it maximizes the transmission. The recently introduced antireflection temporal coatings (ATCs) [Optica7, 323 (2020)10.1364/OPTICA.381175] have been considered as its temporal analog. However, our study shows that by introducing an ATC, not only will the reflection be reduced but also the transmission. This phenomenon is opposite its spatial counterpart, which indicates that ATCs are more than simply a temporal dual of quarter-wavelength matching. This is a direct consequence of the different physical phenomena that are manifested in the temporal and spatial domains.