cssi/SciSciGPT-SciSciNet huggingface dataset:
Serum Uric Acid: Novel Prognostic Factor in Primary Systemic Amyloidosis

OBJECTIVE To determine the prognostic value of serum uric acid (UA) in patients with primary systemic (light chain) amyloidosis (AL). PATIENTS AND METHODS A cohort of 1977 patients with newly diagnosed AL seen at our institution between April 1, 1960, and August 1, 2006, and 293 patients with AL who underwent peripheral blood stem cell transplant between March 1, 1996, and October 1, 2006, were studied retrospectively to examine the value of serum UA. The prognostic value of several variables was examined using Cox proportional hazards models, and the survival time was estimated using Kaplan-Meier analysis; curves were compared using the log-rank test. RESULTS Patients with UA levels greater than 8 mg/dL had a median overall survival of 9 months from diagnosis compared with 20.3 months for the remaining patients ( P 8 mg/dL; cTnT, >0.035 ng/mL; and NTProBNP, >332 pg/mL) had a median overall survival of 36.6, 29.2, 11.1, and 3.6 months, respectively ( P CONCLUSION The data confirm the prognostic utility of cTnT and NTProBNP in a large group of patients and highlight the value of serum UA in allowing better forecasting of probable outcomes for patients with AL.
Cognitive vulnerability to depression

Rick E. Ingram, Jeanne Miranda, and Zindel V. Segal, The Guilford Press, New York, 1998, 330 pp., $37.95.
Generalized gamma parameter estimation and moment evaluation

The generalized gamma distribution includes the exponential distribution, the gamma distribution, and the Weibull distribution as special cases. It also includes the log-normal distribution in the limit as one of its parameters goes to infinity. Prentice (1974) developed an estimation method that is effective even when the underlying distribution is nearly log-normal. He reparameterized the density function so that it achieved the limiting case in a smooth fashion relative to the new parameters. He also gave formulas for the second partial derivatives of the log-density function to be used in the nearly log-normal case. His formulas included infinite summations, and he did not estimate the error in approximating these summations. We derive approximations for the log-density function and moments of the generalized gamma distribution that are smooth in the nearly log-normal case and involve only finite summations. Absolute error bounds for these approximations are included. The approximation for the first m...
Two Bathointermediates of the Bacteriorhodopsin Photocycle, from Time-Resolved Nanosecond Spectra in the Visible

Time-resolved measurements were performed on wild-type bacteriorhodopsin with an optical multichannel analyzer in the spectral range 350−735 nm, from 100 ns to the photocycle completion, at four temperatures in the 5−30 °C range. The intent was to examine the possibility of two K-like bathochromic intermediates and to obtain their spectra and kinetics in the visible. The existence of a second K-like intermediate, termed KL, had been postulated (Shichida et al., Biochim. Biophys. Acta 1983, 723, 240−246) to reconcile inconsistencies in data in the pico- and microsecond time domains. However, introduction of KL led to a controversy, since neither its visible spectrum nor its kinetics could be confirmed. Infrared data (Dioumaev and Braiman, J. Phys. Chem. B 1997, 101, 1655−1662) revealed a state which might have been considered a homologue to KL, but it had a kinetic pattern different from that of the earlier proposed KL. Here, we characterize two distinct K-like intermediates, KE (“early”) and KL (“late”), ...
Supervisor Preferences for the Design and Delivery of Training

Although the consensus is that training for child protective services (CPS) supervisors is essential, there is an apparent gap in the literature about how the training should be delivered. Using interviews, focus groups, and a statewide survey, supervisors in Arizona identified how, when, and where they wanted training delivered and their reasons why. The preferred methods balance training within the responsibilities and time demands of the supervisor role.
Loan Performance of Group-Based Microcredit Programs in the United States:

Peer group lending programs in the United States adapt methodologies first used in developing countries and apply them domestically to benefit low-income communities. This article investigates the effects of context, program design, and staff as well as peer group actions on the loan performance of such programs in the United States. Based on surveys of programs across the country, loan delinquency is primarily a function of context, especially the credit risk of borrowers and time. However, evidence suggests that the payoff structure and peer group actions have discouraged some loan default. Peer group members must be persistently more vigilant than pro- gram staff members throughout the process to ensure loan repayment within the group. Expanding the clientele to the working poor in small towns and rural areas rather than focusing on welfare recipients in big cities may ensure greater financial viability of these programs in the United States.
Lp Exponential Stability for the Equilibrium Solutions of the Navier-Stokes Equations

The exponential stability of the solution of the Navier-Stokes equation in Lp, p > 2, p ≠ 3, in bounded domain is considered in this paper. Under some assumptions on the external force, it can be shown that the bounded solution of the Navier-Stokes equation with initial and boundary conditions approaches the stationary solution of the system exponentially when time t goes to infinite.
Effect of Calcium Carbonate Particle Size on the Available Phosphorus Requirement of Broiler Chicks

Abstract Sixteen hundred broiler strain cockerels housed in battery brooders 1 to 21 days of age were used to determine the effect of feeding different commercially available particle-sized calcium carbonate (CaCO3) on the phosphorus requirement. Five replicates of 8 chicks each were fed corn-soy type diets consisting of either 12 to 20, 20 to 60, or 100 to 200 (passed-retained basis) United States Bureau of Standards (USBS) sieve-sized CaCO3 Each particle-sized CaCO3 was fed in diets containing either .20 to .30% (Experiment 1), .15 to 30% (Experiment 2), or .20 to .45% (Experiment 3) available phosphorus (AP) with .05% increments. Supplementary phosphorus was added as sodium phosphate monobasic. Tibia ash and body weight were greater when the USBS 20 to 60 particle-sized CaCO3 was fed than when either the USBS 12 to 20 or 100 to 200 particle-sized CaCO3 was fed. When .90% dietary calcium was fed to broiler chicks, the phosphorus requirement was either .35% AP with the USBS 20 to 60 particle-sized CaCO3 or at least .45% AP with either the USBS 12 to 20 or 100 to 200 particle-sized CaCO3. Blood alkaline phosphatase, which indicates bone calcification, was inversely correlated (r = –.65) with bone ash. Blood calcium and blood phosphorus increased, and blood alkaline phosphatase decreased with increasing dietary phosphorus. These data show that the 21-day-old broiler chick's available phosphorus requirement is less in corn-soybean meal diets containing a USBS 20 to 60 particle-sized CaCO3 than in diets containing either the USBS 12 to 20 or 100 to 200 particle-sized CaCO3
Data Resources For Sensor Fusion

Advances in our sensor-fusion capabilities are often limited by the lack of appropriate data of scenes and objects acquired by selected sensors. This limitation is severe for sensor-fusion techniques that view objects in space for which observations are costly and require long lead times to plan. An alternative to making the observations is to acquire the data from test results already resident in various collections. This paper reviews the requirements for optical and radar data sets to advance sensor-fusion performance, and shows that these data sets can be identified using existing or developing automated catalogs. Examples are described in which disparate data are brought together to support the development of unique sensor-fusion techniques at a fraction of the cost and time required for observations dedicated to specific sensor-fusion schemes.
Sulfation of cholesterol in rat kidney and liver

Abstract Supernatant fractions obtained by high speed centrifugation of rat kidney and liver homogenates incorporated sulfate- 35 S into an endogenous lipid. The radioactive product was identified as cholesterol sulfate- 35 S by thin-layer chromatography and by co-crystallization with authentic cholesterol sulfate. More sulfate- 35 S was incorporated into the lipid fraction when non-radioactive cholesterol was added to the incubation mixture. When tritium labeled cholesterol was added to the supernatant fraction from kidney, tritium labeled cholesterol sulfate was formed. Following parenteral administration of sulfate- 35 S, cholesterol sulfate- 35 S was identified as the predominant radioactive lipid in the kidney and liver. These studies demonstrate the presence of cholesterol sulfotransferase activity in rat kidney and liver.
Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos.

Abstract Background: RNA interference (RNAi) is a phenomenon in which introduced double-stranded RNAs (dsRNAs) silence gene expression through specific degradation of their cognate mRNAs. Recent analyses in vitro suggest that dsRNAs may be copied, or converted, into 21–23 nucleotide (nt) guide RNAs that direct the nucleases responsible for RNAi to their homologous mRNA targets. Such small RNAs are also associated with gene silencing in plants. Results: We developed a quantitative single-embryo assay to examine the mechanism of RNAi in vivo . We found that dsRNA rapidly induced mRNA degradation. A fraction of dsRNAs were converted into 21–23nt RNAs, and their time of appearance and persistence correlated precisely with inhibition of expression. The strength of RNAi increased disproportionately with increasing dsRNA length, but an 80bp dsRNA was capable of effective gene silencing. RNAi was saturated at low dsRNA concentration and inhibited by excess unrelated dsRNA. The antisense strand of the dsRNA determined target specificity, and excess complementary sense or antisense single-stranded RNAs (ssRNAs) competed with the RNAi reaction. Conclusions: Processed dsRNAs can act directly to mediate RNAi, with the antisense strand determining mRNA target specificity. The involvement of 21–23nt RNAs is supported by the kinetics of the processing reaction and the observed size dependence. RNAi depends on a limiting factor, possibly the nuclease that generates the 21–23mer species. The active moiety appears to contain both sense and antisense RNA strands.
Bragg structure and the first spectral gap

Abstract Periodic media are routinely used in optical devices and, in particular, photonic crystals to create spectral gaps, prohibiting the propagation of waves with certain temporal frequencies. In one dimension, Bragg structures, also called quarter-wave stacks, are frequently used because they are relatively easy to manufacture and the spectrum exhibits large spectral gaps at explicitly computable frequencies. In this short work, we use variational methods to demonstrate that within an admissible class of pointwise-bounded, periodic media, the Bragg structure uniquely maximizes the first spectral gap-to-midgap ratio.
Complex fluids: Spread the word about nanofluids

Liquid spreads and wets a surface, but wetting behaviour changes if the liquid contains nanoparticles. New experiments point to an explanation and a way to create effective detergents for cleaning oil from a surface.
Surgical treatment of lateral rectus muscle paralysis.

We conducted a retrospective study of 55 cases to investigate the effectiveness of three different surgical procedures (medial rectus muscle recession and lateral rectus muscle resection in 16 cases, the Hummelsheim procedure in 27 cases, and the Jensen procedure in 12 cases) in the treatment of lateral rectus muscle paralysis. All three procedures were equally effective. Shorter duration of lateral rectus muscle paralysis, greater preoperative lateral version, less contracture of the medial rectus muscle, and a traumatic origin for the sixth cranial nerve damage had a significant effect (P
A protein structure predictor based on an energy model with learned parameters

Abstract A new protein folding model for obtaining low-level structure information from sequence is constructed. Its form is related both to a parameterized energy function to represent the folding problem and a feed-back “neural network”. The values of unknown physical quantities appear as free parameters in this potential function. Ideas from the study of neural network models are used to develop a learning algorithm that finds values for the free parameters by using the database of known protein structures. This algorithm can be implemented in parallel on a multicomputer. The ideas are illustrated on a simple model of α-helix formation and prediction and used to investigate the role of hydrophobic forces in stabilizing helix hydrogen bonds.
Reminiscence as an Intervention: Rediscovering the Essence of Nursing

The authors initiated an educational program to teach homecare nurses and aides how to implement and evaluate one creative nursing intervention-reminiscence with clients. Client outcomes resulting from the implementation of reminiscence included increased opportunities for self-expression, enhanced coping abilities, the discovery of significance and continuity of life, and enjoyment. Positive staff outcomes also were achieved. The authors conclude that the implementation of creative nursing interventions can assist nurses to rediscover the art and enjoyment inherent in nursing practice and produce positive client outcomes in the current changing healthcare environment.
Differential effects of low-phenylalanine protein sources on brain neurotransmitters and behavior in C57Bl/6- Pahenu2 mice

Phenylketonuria (PKU) is an inborn error of metabolism caused by a deficiency of the enzyme phenylalanine hydroxylase, which metabolizes phenylalanine (phe) to tyrosine. A low-phe diet plus amino acid (AA) formula is necessary to prevent cognitive impairment; glycomacropeptide (GMP) contains minimal phe and provides a palatable alternative to the AA formula. Our objective was to assess neurotransmitter concentrations in the brain and the behavioral phenotype of PKU mice (Pah(enu2) on the C57Bl/6 background) and how this is affected by low-phe protein sources. Wild type (WT) and PKU mice, both male and female, were fed high-phe casein, low-phe AA, or low-phe GMP diets between 3 and 18 weeks of age. Behavioral phenotype was assessed using the open field and marble burying tests, and brain neurotransmitter concentrations were measured using HPLC with electrochemical detection system. Data were analyzed by 3-way ANOVA with genotype, sex, and diet as the main treatment effects. Brain mass and the concentrations of catecholamines and serotonin were reduced in PKU mice compared to WT mice; the low-phe AA and GMP diets improved these parameters in PKU mice. Relative brain mass was increased in female PKU mice fed the GMP diet compared to the AA diet. PKU mice exhibited hyperactivity and impaired vertical exploration compared to their WT littermates during the open field test. Regardless of genotype or diet, female mice demonstrated increased vertical activity time and increased total ambulatory and horizontal activity counts compared with male mice. PKU mice fed the high-phe casein diet buried significantly fewer marbles than WT control mice fed casein; this was normalized in PKU mice fed the low-phe AA and GMP diets. In summary, C57Bl/6-Pah(enu2) mice showed an impaired behavioral phenotype and reduced brain neurotransmitter concentrations that were improved by the low-phe AA or GMP diets. These data support lifelong adherence to a low-phe diet for PKU.
Proposed design guidelines for strengthening of steel bridges with FRP materials

Abstract This paper focuses on the use of externally bonded high modulus carbon fiber reinforced polymer (HM CFRP) materials to strengthen steel bridges and structures. Proper installation of the CFRP materials is necessary to prevent premature failure due to debonding. The paper proposes guidelines and installation techniques based on the best practice reported in the literature and the extensive practical experience in bonding of composite materials. The surface preparation of the materials, the application of the adhesive and the detailing of the strengthening are provided in detail. The design guidelines include the structural design criteria for the use of high modulus CFRP materials as flexural strengthening system of typical steel–concrete composite bridge girders. The flexural design procedure is based on a moment–curvature analysis and a specified increase of the live load carried by the bridge to satisfy specific serviceability requirements. A bond model is also described which can be used to calculate the shear and peel stresses within the adhesive thickness. To prevent a premature debonding failure of the strengthening system, the criteria specify a maximum principle stress in the adhesive which cannot be exceeded for a given characteristic strength of an adhesive. A worked example is presented to illustrate the proposed flexural design approach. The research findings conclude that high modulus CFRP materials provide a promising alternative for strengthening steel bridges that can be easily designed and installed to increase their strength and stiffness.
Food plant choices of two goldenrod beetles: Relation to plant quality

The leaf beetles Trirhabda borealis and T. virgata are specialist herbivores of meadow goldenrods, Solidago spp., in central New York. Upon emergence, both larvae and adults must actively search for food plants, and must choose among the five goldenrod species (S. canadensis, S. gigantea, S. graminifolia, S. juncea and S. rugosa) that co-occur in old fields. The relationship between Trihabda foraging decisions and plant quality was examined by comparing food preferences in the field with the performance of beetles caged on each host. Trirhabda adults were highly selective in their use of food plants. Adults of T. borealis preferred a single host, S. canadensis, while T. virgata adults were most common on S. canadensis and S. gigantea. These preferences were not strictly related to variation in plant quality. In the laboratory, T. borealis performed equally well on four goldenrods (but completely failed to reproduce when fed S. graminifolia), and T. virgata performed equally well on all five hosts.Larval feeding preferences in each beetle species were broader, and were more in accord with subtle variation in plant quality. Newly-hatched T. borealis larvae readily colonized four hosts and rejected only S. graminifolia, which conferred the lowest survivorship and the slowest growth. Larvae of T. virgata accepted each host, even though growth rates were somewhat slower on S. graminifolia and S. juncea.Ontogenetic differences in host preference and host tolerance may have evolved because of the different host-finding abilities of each beetle stage. During host search, the sluggish, newly-emerged larvae may be more food-limited and accept even marginally inferior food plants. The relatively mobile adults are more discriminating and use a subset of suitable hosts. The intermingled dispersion of Solidago species in old fields results in frequent larval colonization of hosts seldom used by adults. In diverse plant communities, ultimate patterns of food plant choice can be a complex function of at least three factors: intrinisic plant quality, local plant dispersion, and the host-search abilities of the insect forager.
R&D Spillovers: Evidence from U.S. Food Processing, Farm Machinery and Agricultural Sectors

This paper computes private and social rates of return to R&D capital in the three vertically linked sectors, primary agriculture, food processing, and the farm machinery in the United States. Using a cost function approach, the private rates of return to R&D ranged from an average of 21.5% per annum for farm machinery to 87.5% for agriculture. The social rates of return to R&D in food processing and farm machinery are larger than the private rates due to spillovers. We find that spillovers from public agricultural R&D mitigates the market's failure in farm machinery to fully appropriate the returns to its R&D capital.
Rhabdomyolysis in a neonate due to very long chain acyl CoA dehydrogenase deficiency

Very long chain acyl CoA dehydrogenase deficiency (VLCADD) is an inborn error in long chain fatty acid oxidation with significant variability in the severity and timing of its clinical presentation. Neonatal presentations of VLCADD have included hypoglycemia and cardiomyopathy while rhabdomyolysis is usually a later onset complication. We describe a neonate with VLCADD presenting with rhabdomyolysis prior to the return of an abnormal newborn screen. This report suggests that evaluating for rhabdomyolysis, in addition to a cardiac and hepatic work-up, is an important part of the initial evaluation of an infant with an abnormal newborn screen suggesting a diagnosis of VLCADD.
Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans.

GBR12909 (GBR) is a high-affinity, selective, and long-acting inhibitor of dopamine (DA) uptake that produces a persistent and noncompetitive blockade of DA transporters and substantially reduces cocaine-induced increases in extracellular DA in the nucleus accumbens of rats. Prior studies showed that intravenous infusion of GBR to Rhesus monkeys selectively reduced (1 mg/kg) and eliminated (3 mg/kg) cocaine self-administration. This study tested the hypothesis that doses of GBR that reduce cocaine self-administration in nonhuman primates produce significant occupation of DA transporters. DA transporters were quantitated in two baboons using [11C]WIN35,428 and positron emission tomography (PET). Each baboon underwent paired control/blocked PET scans (performed on three separate study days, 3-4 weeks apart). On the first scan the baboon received saline (3 ml/kg) 90 minutes before the injection of the radiotracer. GBR (1 mg/kg i.v.) was infused 90 minutes before the second [11C]WIN 35,428 study. The same experimental design was repeated with GBR doses of 3 and 10 mg/kg, respectively. Doses of 1 (n = 2), 3 mg/kg (n = 2), and 10 mg/kg (n = 2) reduced binding potential by 26, 53, and 72%, respectively. GBR was well tolerated in all baboons. These results demonstrate that doses of GBR that suppress cocaine self-administration in nonhuman primates also produce high occupancy of the DA transporter. These data strongly suggest that occupancy for the DA transporter by GBR explains its ability to attenuate cocaine-induced increases in extracellular DA and to suppress cocaine self-administration. Moreover, these data suggest that experimental human studies of orally administered GBR to test the DA hypothesis of cocaine addiction should use doses that produce at least 70% occupancy of the DA transporter.
Synchronization of the Probes of a Distributed Instrument for Real-Time Ethernet Networks

This work deals with distributed, multi-probe, instrument for performance analysis of Real-Time Ethernet (RTE) network Particularly, the work is focused on synchronization techniques for distributed measurements. In fact, the accuracy of results (typically jitter and delay) strictly depends on synchronization among distributed probes that sample data. Three synchronization techniques have been implemented and experimental results are reported. Synchronization by means of an external dedicated l-PPS signal gives the best results but requires a more complicated instrument structure. On the other hand, a network-oriented synchronization, such as IEEE 1588 FTP or PCTP (PROFINET 10), can simplify time distribution keeping accuracy well below 1 mus.
Posterior penetrating injury in the rabbit eye: Effect of blood and ferrous ions

The effects of intravitreal injections of blood or ferrous chloride solutions on experimental posterior penetrating eye injury in the rabbit are described. An 8-mm standard posterior penetrating wound, without additional manipulation, healed without retinal detachment or membrane formation. Injection into the vitreous cavity of blood or ferrous chloride solution in addition to the wound resulted in fibroblastic proliferation with membrane formation. A critical amount of blood or iron solution was associated with marked traction and traction retinal detachment. Severe inflammation in association with the development of thick intravitreal membranes was also observed in eyes receiving the ferrous chloride solutions, the extent of which was related to the severity of the retinal detachment. These results show that iron is an important stimulus to inflammation and to intravitreal fibroblastic proliferation in rabbit eyes with posterior penetrating eye injuries.
Development of a Markerless Genetic Exchange System for Desulfovibrio vulgaris Hildenborough and Its Use in Generating a Strain with Increased Transformation Efficiency

In recent years, the genetic manipulation of the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough has seen enormous progress. In spite of this progress, the current marker exchange deletion method does not allow for easy selection of multiple sequential gene deletions in a single strain because of the limited number of selectable markers available in D. vulgaris. To broaden the repertoire of genetic tools for manipulation, an in-frame, markerless deletion system has been developed. The counterselectable marker that makes this deletion system possible is the pyrimidine salvage enzyme, uracil phosphoribosyltransferase, encoded by upp. In wild-type D. vulgaris, growth was shown to be inhibited by the toxic pyrimidine analog 5-fluorouracil (5-FU), whereas a mutant bearing a deletion of the upp gene was resistant to 5-FU. When a plasmid containing the wild-type upp gene expressed constitutively from the aph(3′)-II promoter (promoter for the kanamycin resistance gene in Tn5) was introduced into the upp deletion strain, sensitivity to 5-FU was restored. This observation allowed us to develop a two-step integration and excision strategy for the deletion of genes of interest. Since this in-frame deletion strategy does not retain an antibiotic cassette, multiple deletions can be generated in a single strain without the accumulation of genes conferring antibiotic resistances. We used this strategy to generate a deletion strain lacking the endonuclease (hsdR, DVU1703) of a type I restriction-modification system that we designated JW7035. The transformation efficiency of the JW7035 strain was found to be 100 to 1,000 times greater than that of the wild-type strain when stable plasmids were introduced via electroporation.
The Legislative Role of Juries

Is it possible that jurors, in the process of evaluating the evidence against a defendant, act to some degree as legislators by assessing the soundness of policies they perceive the criminal law to be supporting? To test the hypothesis that jurors reflect public opinion in making such judgments, the author correlated changes in public opinion on war policy with fluctuations in the proportion of jury trial defendants found guilty of violating selective service laws. It was found that juries convicted those accused of draft evasion at a higher rate when a war was in progress than during peacetime and that during the Korean and Vietnam wars the conviction rate was directly correlated with public approval of American military actions, A breakdown of regional differences showed that the South was somewhat more supportive of the Vietnam War and more prone to convict in selective service cases than the rest of the nation was, but the results of this comparative analysis were inconclusive. Although the correspondence between public opinion and verdict tendencies was far from perfect (perhaps in part because of the skewed composition of juries), the study does sup port the notion that jurors draw on prevailing popular sentiments about laws and the public policies the laws further.
Semiautomated autoradiographic measurement of DNA repair in normal and xeroderma pigmentosum cultured human fibroblasts

Assessment of DNA repair in cultured human fibroblasts by autoradiography may be facilitated by using semiautomated grain counting instruments. The instrument-determined number of autoradiographic grains per nucleus in cultured human skin fibroblasts was found to be linear in comparison to visual counts up to only 30 grains per nucleus. However, with two different instruments a greater range of linearity (to 100 to 120 grains per nucleus) was attained by measuring the grain surface area per nucleus. Semiautomated analysis of the grain surface area per nucleus yielded measurements of relative rates of unscheduled DNA synthesis after ultraviolet irradiation in xeroderma pigmentosum and normal human fibroblasts, which were reproducible and rapid.
Hydrophobic ion pairing of isoniazid using a prodrug approach

Inhalation therapy for infectious lung diseases, such as tuberculosis, is currently being explored, with microspheres being used to target alveolar macrophages. One method of drug encapsulation into polymeric microspheres to form hydrophobic ion-paired (HIP) complexes, and then coprecipitate the complex and polymer using supercritical fluid methodology. For the potent antituberculosis drug, isoniazid (isonicotinic acid hydrazide, INH), to be used in this fashion, it was modified into an ionizable form suitable for HIP. The charged prodrug, sodium isoniazid methanesulfonate (Na-INHMS), was then ion paired with hydrophobic cations, such as alkyltrimethylammonium or tetraalkylammonium. The logarithms of the apparent partition coefficients (log P') of various HIP complexes of INHMS display a roughly linear relationship with the numbers of carbon atoms in the organic counterions. The water solubility of the tetraheptylammonium-INHMS complex is about 220-fold lower than that of Na-INHMS, while the solubility in dichloromethane exceeds 10 mg/mL, which is sufficient for microencapsulation of the drug into poly(lactide) microspheres. The actual logarithm of the dichloromethane/water partition coefficient (log P) for tetraheptylammonium-INHMS is 1.55, compared to a value of - 1.8 for the sodium salt of INHMS. The dissolution kinetics of the tetraheptylammonium-INHMS complex in 0.9% aqueous solutions of NaCl was also investigated. Dissolution of tetraheptylammonium-INHMS exhibited a first-order time constant of about 0.28 min(-1), followed by a slower reverse ion exchange process to form Na-INHMS. The half-life of this HIP complex is on the order of 30 min, making the enhanced transport of the drug across biological barriers possible. This work represents the first use of a prodrug approach to introduce functionality that would allow HIP complex formation for a neutral molecule.
Network Sampling with Memory: A proposal for more efficient sampling from social networks

Techniques for sampling from networks have grown into an important area of research across several fields. For sociologists, the possibility of sampling from a network is appealing for two reasons: (1) A network sample can yield substantively interesting data about network structures and social interactions, and (2) it is useful in situations in which study populations are difficult or impossible to survey with traditional sampling approaches because of the lack of a sampling frame. Despite its appeal, methodological concerns about the precision and accuracy of network-based sampling methods remain. In particular, recent research has shown that sampling from a network using a random walk–based approach such as respondent-driven sampling (RDS) can result in a high design effect (DE): the ratio of the sampling variance to the sampling variance of simple random sampling (SRS). A high DE means that more cases must be collected to achieve the same level of precision as SRS. In this article, we propose an alter...
A serological comparison of some species of microsporida

Abstract Double immunodiffusion techniques were used to investigate the taxonomic relationships between six different microsporidian isolates. Microsporidia used included Nosema bombycis, N. algerae, N. plodiae , and three organisms morphologically similar to N. necatrix . Antigens were extracted from spores after disruption in an MSK Braun cell homogenizer. Cross-reactions were seen between N. plodiae and two of the N. necatrix isolates, while the third N. necatrix, N. bombycis , and N. algerae were antigenically unrelated. One of the N. necatrix isolates revealed temperature-related antigenic differences, but no antigenic differences resulted from aging spores for 5 months before disruption.
Epidemiology of Acute Rheumatic Fever in a Multiethnic, Multiracial Urban Community: The Miami-Dade County Experience

During the mid-1980s, several US communities experienced outbreaks of acute rheumatic fever (ARF), often involving predominantly white, middle-class individuals living in suburban or rural settings. The medical records of all patients diagnosed with ARF in Miami-Dade County, Florida, between 1984 and 1988 were reviewed. Thirty-five cases met the revised Jones criteria and were considered definite; four additional cases were classified as probable. Carditis was present in 54%. Of the 39 patients, 32 (82%) were black. The annual incidence of ARF among black children aged 5-14 years was 12.25 per 100,000 compared to 0.71 for other (non-Hispanic white plus Hispanic) children (P less than .001). ARF was centered in the inner city, where the incidence among black children reached 15.21. Despite the multiethnic, multiracial character of Miami-Dade County and the rapid influx of immigrants, ARF in this community remains primarily a disease of underprivileged, black inner-city children.
The oestrous cycle of the mare and its uterine control.

SUMMARY The reproductive findings from a group of nonpregnant mares were studied. Oestrous cycle length averaged 20.6 days (range 13–34) excluding anoestrous periods, or 25 days (31–141) if included. Average oestrus length was 5.7 days (range 1–24) but from February to May it averaged 7.6 days (range 2–24) and from May to November 4.8 days (range 1–10). Seventy-eight per cent of the mares ovulated within 48 hours prior to the end of oestrus, 10% were out of oestrus before ovulation occurred, while 76% of the ovulations occurred between 4 p.m. and 8 a.m. Follicles averaged 45 mm in size the day of ovulation and multiple ovulations occurred 25.5% of the time. Oestrus without associated ovulation was very uncommon in this group of mares, whereas ovulation without oestrus occurred in 6 of the 11 mares, including one mare who ovulated 32 of 34 times without oestrus. The CL were palpable for an average period of 8.9 days (range 1–18). On occasions, a hematoma formed within the ovulation site, reached a size of 10–12 cm in length and persisted beyond the next ovulation without affecting cycle length. Dioestrus averaged 15.4 days (range 6–25) excluding anoestrus, or 19.5 days (range 6–121) if anoestrus was included. Dioestrous ovulations unaccompanied by signs of oestrus and with the cervix pale, tight, dry and sticky occurred in 10 of the 11 mares. The CL formed following dioestrous ovuations were normal, but did not affect cycle length. A syndrome of spontaneous prolongation of the corpus luteum for 2 to 3 months was observed in 6 of the 11 mares. Oestrus was not manifested during this time, but considerable follicular activity and, in some instances, ovulation was observed. Hysterectomised mares and some mares with pyometra had prolonged CL and follicular activity with a few ovulating similar to mares with spontaneously-prolonged CL. Other mares with pyometra had normal cyclic ovarian activity. Evidence suggests that the endometrium had been destroyed by the infection in the anoestrus mares with pyometra and, thus, was incapable of forming and/or releasing luteolytic factors. Experimental intrauterine inoculation of Streptococcus zooepidemicus during dioestrus reduced oestrous cycle length in 5 of 7 inoculations, whereas inoculations during oestrus failed to alter cycle length.
Social Roles and Social Judgment: How an Impression Conveyed Influences an Impression Formed

Two studies examined the effect of enacting a social role on perceptions of a partner in a simulated interaction. Subjects were led to believe they were interacting with a partner whom they saw on a TV monitor (which actually showed a videotaped recording). Subjects evaluated the introversion/extraversion of their 'interaction partner. " Those instructed to enact an introvert role saw the partner as more extraverted than those who enacted an extravert role. Study 2 showed that, compared with a control group that did not enact a role, extraverts saw the person as more introverted (though not statistically significantly so), whereas introverts saw the person as more extraverted. Neither study found an effect of subjects' actual personality classification as introverts or extraverts. These findings have implications for the relative importance of temporary and chronic construct activation in social perception.
Acute disseminated encephalomyelitis: an MRI/MRS longitudinal study

A clinical and radiologic diagnosis of acute disseminated encephalomyelitis was made in two children: a 6-month-old female who presented with focal seizures and thalamic and cerebral white matter lesions, and a 4.5-year-old male who presented with tremor and dystonia and had bilateral basal ganglia lesions, without evidence of active brain infection. Serial clinical and laboratory evaluations were supplemented by neuroimaging including routine magnetic resonance imaging and (1)H magnetic resonance spectroscopy. They were treated symptomatically, without using steroids or intravenous immunoglobulin, and both children recovered. Single voxel (1)H magnetic resonance spectroscopy data were acquired from the involved areas and from normal-appearing white matter. Abnormalities in N-acetyl-aspartate, choline, and lactate peaks were evident during the symptomatic phase, and persistence of low N-acetyl-aspartate was observed during recovery. These spectroscopic findings are consistent with neuropathologic findings of neuronal dysfunction, cellular membrane turnover, cellular infiltration, and metabolic stress in the acute phase, and with neuronal loss in the chronic phase.
TURKEY'S QUEST FOR PEACEFUL NUCLEAR POWER

(1997). Turkey's quest for peaceful nuclear power. The Nonproliferation Review: Vol. 4, No. 3, pp. 33-44.
The use of virtual reality for people with balance and vestibular disorders: the Pittsburgh experience

Abstract Objective: The purpose of this paper is to describe our experiments with virtual reality in the treatment of people with vestibular disorders. We will share insights about virtual reality use in people with complaints of dizziness and balance loss. Methods: Two experiments measured simulator sickness and discomfort in people with and without dizziness when viewing simulations that manipulated optic flow or required navigation and object recognition. A third experiment tested transfer of virtual environment training to self-report and balance performance measures for a group of individuals with vestibular hypofunction. Results: People with vestibular disease had greater symptoms in optic flow and virtual environments, but not greater than that which is experienced in conventional vestibular rehabilitation. Overall, patients improved on both self-perception and objective measures of balance and postural control. Discussion: Our next goal is to determine if virtual reality intervention is superior t...
Rural women and state policy: The Latin American agrarian reform experience

Abstract This review of 13 Latin American agrarian reforms shows that most have directly benefited only men. It is argued that this is largely because of the common designation of ‘households’ as the beneficiaries of an agrarian reform and the subsequent incorporation of only male household heads into the new agrarian reform structures. It is shown that a necessary, but not sufficient, condition for rural women to benefit on par with men is that they too be designated as beneficiaries. Women as well as men must be given access to land or the opportunity to participate within the agrarian cooperatives or state farms promoted by an agrarian reform. This comparative analysis of the Latin American agrarian reform demonstrates that this has happened only in countries where the incorporation of rural women to the reform is an explicit objective of state policy.
Reactivation and immunological studies on a japanese variant of red cell carbonic anhydrase I, CA I hiroshima-1

Abstract 1. 1. Under certain conditions, CA I HIR-1‡ (86 Asp→ Gly) was inactivated in Gnd-HCl more rapidly than normal CA I. 2. 2. After denaturation in 5.0 M Gnd · HC1, CA I HIR-1 was reactivated more slowly than normal CA I. 3. 3. CA I HIR-1 was precipitated by purified anti-CA I antibodies, under certain conditions, more rapidly than normal CA I.
Concurrent oral shedding of feline calicivirus and feline herpesvirus 1 in cats with chronic gingivostomatitis

Oral mucosal salivary samples were collected from 25 cats with chronic gingivostomatitis and 24 cats with periodontal disease. Viral culture and isolation of feline calicivirus and feline herpesvirus 1 were performed. Eighty-eight per cent of cats with chronic gingivostomatitis were shedding both viruses, compared to 21% of cats without chronic oral inflammatory disease. Cats with chronic gingivostomatitis are significantly more likely to concurrently shed both feline calicivirus and feline herpesvirus 1 than are cats with classical periodontal disease.
Chiral recognition in the gas phase: Mass spectrometric studies of diastereomeric cobalt complexes.

Results of mass analyzed ion kinetic energy (MIKE) spectra and kinetic energy release (KER) measurements of diastereomeric octahedral cobalt complexes indicate that these diastereomers can be distinguished in the gas phase. Four alkyl tartrate esters were complexed to cobalt trisacetylacetonate (Co(acac)3) in the presence of a chiral auxiliary, RR- and SS-threohydrobenzoin. Different KER values of the product ion generated from [Co(acac)2/D- or L-diisopropyl tartrate]+ reflect differences in the precursor ion structure. The dissociation pathway resulting in this product ion is believed to arise via a hydride transfer from the acetylacetonate ligand to the metal center with subsequent loss of neutral organic species. It has been established that two conditions are necessary for observation of chiral recognition in this system; (1) the cobalt complex must be octahedral and (2) a chemical kinetic resolving agent must be present during formation of the complex.
Increased CRH mRNA levels in the rat amygdala during short-term withdrawal from chronic 'binge' cocaine.

Abstract There is evidence that suggests that increased corticotropin-releasing hormone (CRH) release in the central nucleus of the amygdala underlies the anxiogenic and stress-like consequences of withdrawal that are common in phenomenology to all drugs of abuse. The present studies were undertaken to determine levels of CRH mRNA in the amygdala, and also in the hypothalamus, frontal cortex and brainstem after short-term (2 days) and intermediate-term (10 days) cocaine withdrawal (with continued saline injections) from chronic (14 days) ‘binge’ pattern cocaine administration (3×15 mg/kg per day at hourly intervals). Confirming our recent finding of an activation of stress responsive hypothalamic–pituitary–adrenal activity during early cocaine withdrawal, there was a significant elevation of plasma corticosterone level after 2-day cocaine withdrawal. There was also a significant elevation of CRH mRNA levels in the amygdala, but not in the hypothalamus, frontal cortex or brainstem after 2-day cocaine withdrawal. A negative correlation between amygdalar CRH mRNA and plasma corticosterone levels was found in the 2-day cocaine withdrawn rats but not in control rats, suggesting that CRH neurons in the amygdala may be differentially responsive to glucocorticoids after chronic cocaine exposure and withdrawal. There were no changes in either plasma corticosterone or amygdalar CRH mRNA levels after 10-day cocaine withdrawal. Our findings of an increase in amygdalar CRH gene expression during early cocaine withdrawal support a potentially important role for amygdalar CRH activity in the anxiogenic and aversive consequences of withdrawal from cocaine during a time when humans are most subject to relapse.
2-[N-(tert-Butoxy­carbonyl)­tyrosyl]-1,2,3,4-tetra­hydro­iso­quinoline-3-carboxyl­ic acid nitro­methane solvate

The title compound, C24H28N2O6·0.825CH3NO2, is a member of the TIPP (i.e. Try–Tic–Phe–Phe) family of opioid ligands. The asymmetric unit contains one peptide mol­ecule and one nitro­methane mol­ecule. Unlike other members of this familiy, this dipeptide has an extended conformation [i.e. φ1 = −103.6 (6)°, ω1 = 168.1 (4)°, ψ1 = 152.4 (5)°]. This conformation was further ex­amined with the program CHEM3D. No significant energy difference was found between the energy-minimized conformation and a more tightly folded model conformation.
Complete primary structure of statherin, a potent inhibitor of calcium phosphate precipitation, from the saliva of the monkey Macaca arctoides

Human saliva, which is supersaturated with respect to basic calcium phosphate salts, is stabilized primarily by the presence of two classes of phosphoproteins, statherin and the acidic proline-rich proteins (PRP). These molecules act by inhibiting both primary (spontaneous) precipitation of calcium phosphates in saliva and secondary (surface induced) precipitation of these salts onto dental enamel. The complete amino-acid sequences of several human PRP and the N-terminal sequence of PRP from saliva of M. arctoides have been determined. Similarly, the complete sequence of statherin from human and M. fascicularis saliva is known. We now report the complete structure of statherin from the saliva of the stump-tailed monkey, M. arctoides. The structure was determined by gas-phase sequencing of intact statherin, elucidating positions 1-26, and sequencing an unpurified mixture of tryptic peptides which elucidated the remaining positions through the C-terminus (residue 42) of the molecule. This latter degradation produced an eight amino-acid overlap with that of intact statherin and was confirmed by C-terminal analysis and amino-acid composition of native statherin. The complete amino-acid sequence of M. arctoides statherin is: NH2-Asp-PSer-PSer-Glu-Glu5-Lys-Phe-Leu-Arg-Arg10 -Leu-Arg-Arg-Phe-Asp15-Glu- Gly-Arg-Tyr-Gly20-Pro-Tyr-Gln-Pro-Phe25-Val-Pro-Pro- Pro29Leu30-Tyr- Pro-Gln-Pro-Tyr35-Gln-Pro-Tyr-Gln-Pro40-Gln-Tyr-COOH This sequence differs from human statherin at positions 11, 12, 15, 16, 18, 25-27, 38-40 and from M. fascicularis statherin at positions 26 and 28.