cssi/SciSciGPT-SciSciNet huggingface dataset:
Intravascular ultrasound-guided catheter-based aspiration thrombectomy in patients with acute submassive pulmonary embolism: A case series

Abstract Contrast pulmonary angiography by hand injection or power injection is widely used during catheter-based therapies for acute submassive and massive pulmonary embolism (PE). Particularly, in patients with pre-existing chronic kidney disease , this approach may present a prognostic challenge owing to a double-contrast load, initially during computed tomographic pulmonary angiography (CTPA), and during percutaneous treatment. Intravascular ultrasound (IVUS) has been used as an adjunctive imaging modality in the percutaneous treatment of chronic thromboembolic pulmonary hypertension , and in coronary and peripheral vascular interventions. We report a series of cases illustrating the use of IVUS in the management of acute PE . All five patients presented with an acute submassive PE with evidence of right ventricular (RV) strain (RV/LV ratio ≥ 0.90). Body mass index and B-type natriuretic peptide ranged from 18 to 47 kgm/m 2 and 56–932 pg/mL (ref. ≤ 78), respectively. Three of the five patients had renal impairment prior to the procedure (acute kidney injury, AKI, and chronic kidney injury, CKD). Post-catheter-directed pulmonary embolectomy there was a modest reduction in mean pulmonary artery pressure in all five patients (range: −4 mmHg to −9 mmHg). The first case serves as a proof of concept of IVUS use in acute PE. This case series demonstrates that an IVUS-only approach in the catheter-directed management of acute submassive PE is feasible and may be of particular importance in patients with pre-existing renal dysfunction.
A Field study comparing fecal egg count reduction, weight gain and product safety in stocker cattle treated with either moxidectin or ivermectin with clorsulon

This study was conducted to assess effectiveness, safety and benefit of injectable moxidectin compared to an injectable ivermectin-clorsulon combination. A total 2,022 stocker calves maintained on 11 Arkansas and Missouri cattle farms were randomly and evenly allocated on each farm into either the moxidectin (MXD) or ivermectin-clorsulon (IC) group. No negative controls were utilized in the study. All treatments were administered on a unique day 0 for each farm. Herd sizes ranged from 54 to 544. Naturally infected mixed breed bull, steer or heifer calves, weighing from 241 to 810 lb (110 to 368 kg) on day 0, were used in the study. On days 0, 50 (approx) and 100 (approx), each animal was weighed, and fecal samples were obtained from 20% of the animals (same animals on each sample day) for determination of fecal nematode egg counts and coproculture larvae identification. Both products were easily administered and no adverse effects were noted following administration of either drug. Weight gain from day 0 did not vary significantly between treatment groups at either of the post-treatment sampling dates. In addition, sex by treatment interaction was not significant (P<0.05), as analyzed on those farms that had both male and female cattle in the study population. On day 0, no significant differences were found between treatment groups for strongyle eggs per gram of feces (EPG) counts or coproculture larvae percentages. For days 50 and 100, EPG counts for MXD-treated calves were significantly lower than those for IC-treated calves (P<0.05). Day 0 coproculture data indicated that the primary nematode parasites contributing to the fecal egg counts were Cooperia, Haemonchus and Ostertagia. On days 50 and 100, MXD-treated animal coprocultures yielded higher larvae percentages of Cooperia than did the IC-treated animal coprocultures (P<0.05), as well as significantly lower Ostertagia and Haemonchus larvae percentages. Egg count and coproculture results suggest that both parasiticides were most limited in their ability to control Cooperia, but greater post-treatment egg production by Cooperia, Ostertagia and Haemonchus occurred in calves treated with IC compared to those in the MXD group.
ZNF146/OZF and ZNF507 target LINE-1 sequences

Abstract Repetitive sequences including transposable elements (TEs) and transposon-derived fragments account for nearly half of the human genome. While transposition-competent TEs must be repressed to maintain genomic stability, mutated and fragmented TEs comprising the bulk of repetitive sequences can also contribute to regulation of host gene expression and broader genome organization. Here we analyzed published ChIP-seq data sets to identify proteins broadly enriched on TEs in the human genome. We show two of the proteins identified, C2H2 zinc finger-containing proteins ZNF146 (also known as OZF) and ZNF507, are targeted to distinct sites within LINE-1 ORF2 at thousands of locations in the genome. ZNF146 binding sites are found at old and young LINE-1 elements. In contrast, ZNF507 preferentially binds at young LINE-1 sequences correlated to sequence changes in LINE-1 elements at ZNF507’s binding site. To gain further insight into ZNF146 and ZNF507 function, we disrupt their expression in HEK293 cells using CRISPR/Cas9 and perform RNA sequencing, finding modest gene expression changes in cells where ZNF507 has been disrupted. We further identify a physical interaction between ZNF507 and PRMT5, suggesting ZNF507 may target arginine methylation activity to LINE-1 sequences.
Educator Perceptions of a Schoolwide Writing Intervention Implementation: Implications for Practice

Students with disabilities continue to perform below peers without disabilities in writing. To address the need for improving written expression for students with learning differences, schools are ...
A Compensation System for Gun Deaths and Injuries

My goal is to construct a compensation program for victims of gun violence. If the victim was killed or suffered serious injury through a negligent or intentional shooting, the survivor recovers stepped compensation. The claimant files a request for compensation with the new Second Amendment Commission. The financial part of the fund will be constructed from three sources: the federal government, the state government and the NRA coupled with the gun manufacturers. The fund will be administered by the Commission. My proposal does not rest on a finding of fault or blame by the contributors. It rests instead on cause in fact. At last gun victims will be compensated and receive more than mere condolences by political leaders.
Provider Training and Education in Disease Management

Disease management has emerged as an important tool to increase quality of care, improve patient outcomes and control costs. Reducing provider practice variation is a key aspect of successful disease management. Clinical practice guidelines are a useful tool to reduce practice variation but are often underutilized. Provider training interventions, particularly using multiple educational strategies, have been proven to be effective in increasing guideline adherence. For maximal effect, provider training must also be combined with system interventions to support and sustain new provider behaviors. Educational technologies encompass electronic-based delivery methods and innovations in instructional design such as adult education, problem-based learning, and competency-based training. Innovations in educational technology are lowering common barriers to provider training such as limited provider time, less provider acceptance of traditional classroom methods and limited organizational training resources. Electronic technologies are central to delivery of distance learning, which uses technology to link instructors separated from learners by time and/or distance. Distance learning includes synchronous methods (which link learners who are separated by geographic distance but allow for simultaneous interaction) and asynchronous methods (which allow for interaction at different times). The range of electronic technologies include relatively simple and inexpensive methods requiring minimal infrastructure such as audio or videotape instruction, to technology-intensive methods such as videoconferencing or telemedicine, involving substantial infrastructure. Computer-assisted learning methods range from simple freestanding programs, to more sophisticated interactive Internet-based instruction, to highly sophisticated and realistic patient simulators. Constraints to implementing innovative educational technologies include providers’ discomfort with electronic technology, increased time and cost of instructor-intensive face-to-face instructional methods and the requirement for extensive infrastructure and technical support of some electronic-based technologies. Selecting appropriate educational technology for disease management provider training requires careful consideration of both program and provider characteristics. More research is needed on the comparative effectiveness, synergies, limitations and health economics of innovative educational technologies in provider training.
Physics at High Pressure

Publisher Summary This chapter introduces the types of measurement that are being made at high pressures, with little regard in many cases, for the fundamental significance of the measurements. Various recent developments in high-pressure techniques are described, with particular emphasis on those techniques, which are applicable to the relatively new low-temperature region. The experimental method is discussed in the chapter. The interpretation of experimental high-pressure data in terms of theoretically calculated quantities is only possible if the experimental pressure scale is identical to the thermodynamic pressure scale. To this end, standards for the calibration of secondary pressure measuring devices have been set up in terms of the fundamental definition of pressure—namely, force per unit area.
Sick Building Syndrome

Sick building syndrome (SBS) is loosely defined as an increase in the frequency of a constellation of acute nonspecific symptoms characteristically affecting multiple occupants of a building.
A Neural Net Predictive Control for Telerobots with Time Delay

This paper extends the Smith Predictor feedback control structure to unknown robotic systems in a rigorous fashion. A new recurrent neural net predictive control (RNNPC) strategy is proposed to deal with input and feedback time delays in telerobotic systems. The proposed control structure consists of a local linearized subsystem and a remote predictive controller. In the local linearized subsystem, a recurrent neural network (RNN) with on-line weight tuning algorithm is employed to approximate the dynamics of the time-delay-free nonlinear plant. The remote controller is a modified Smith predictor for the local linearized subsystem which provides prediction and maintains the desirable tracking performance. Stability analysis is given in the sense of Lyapunov. The result is an adaptive compensation scheme for unknown telerobotic systems with time delays, uncertainties, and external disturbances. A simulation of a two-link robotic manipulator is provided to illustrate the effectiveness of the proposed control strategy.
What Do Subprime Securitization Agreements Say About Mortgage Modification

A review of pooling and servicing agreements from large subprime securitization programs in 2006 reveals that about 10% of the contract ban loan modifications altogether. The other 90% do not seem to forbid win-win loan modifications (defined as modifications that benefit the borrower and increase the present value of cash flows to the trust), although their terms are open-ended enough that reluctance to make such modifications is understandable. If the subprime universe as a whole looks similar to the contracts we have reviewed to date, mass clarification of contracts rather than mass abrogation either through special legislation or through the creation of a special bankruptcy process may be appropriate.
A Slow Manifold Approach to Feedback Control of Nonlinear Flexible Systems

In this paper we consider the control problem for a class of coupled, second-order singularly perturbed nonlinear dynamical systems. The problem has important application to flexible mechanical systems including robot manipulators with flexible joinra, where the singular perturbation parameter ? is the inverse of the joint stiffness. For this class of systems it is known that the reduced order model corresponding to the mechanical system under the assumption of perfect rigidity is globally linearizable via nonlinear state feedback, but that the full order flexible system is not, in general, linearizable. We utilize the concept of integral manifold to represent the dynamics of the slow subsystem, which reduces to the rigid model as the perturbation parameter tends to zero. We show that linearizability of the rigid model implies linearizability of the flexible system restricted to the integral manifold. Based on a power series expansion of the integral manifold around ? = 0 we show how to approximate the feedback linearizing control to any order in ?. The result is a nonlinear feedback control scheme to "stiffen" the nonlinear flexible system. That is, the behavior of the closed loop flexible system is nearly that of the controlled rigid system.
Branch-and-Price Algorithms for the One-Dimensional Cutting Stock Problem

We compare two branch-and-price approaches for the cutting stock problem. Each algorithm is based on a different integer programming formulation of the column generation master problem. One formulation results in a master problem with 0–1 integer variables while the other has general integer variables. Both algorithms employ column generation for solving LP relaxations at each node of a branch-and-bound tree to obtain optimal integer solutions. These different formulations yield the same column generation subproblem, but require different branch-and-bound approaches. Computational results for both real and randomly generated test problems are presented.
Trademark Law's Faux Federalism

Federal and state trademark laws regulate concurrently: The Lanham Act does not preempt state law, and in fact many states have statutorily and/or judicially developed trademark or unfair competition laws of their own. This state of affairs, which is now well-accepted even if it has not always been uncontroversial, distinguishes trademark law from patent and copyright law, since federal patent and copyright statutes preempt state law much more broadly. The Patent Act entirely preempts state law with respect to non-secret inventions and the 1976 Copyright Act preempts state copyright law with respect to all works fixed in a tangible medium of expression.According to the common wisdom, concurrent trademark regulation derives from the historical primacy of state law, which federal law later supplemented but did not supplant entirely. John Cross, for example, argues characteristically that the Lanham Act - builds upon a foundation of state-law rights, leaving states generally free to regulate the field of trademarks. This essay evaluates that claim and its implied premise that state law has always played an important role in trademark law. As it demonstrates, proper characterization of state law‘s historical role depends in substantial part on one‘s understanding of the status of general law before the Supreme Court‘s decision in Erie Railroad Co. v. Tompkins. To illustrate, this essay describes the history of trademark and unfair competition in three periods: (1) the pre-Erie era, in which trademark and unfair competition claims were understood as distinct species of the same general legal right, both of which were substantively determined by the common law; (2) the period after Erie and straddling passage of the Lanham Act, before courts had settled on an interpretation of the statute under which claims for infringement of unregistered trademarks could be brought under §43(a); and (3) the modern era, in which the Supreme Court and Congress have accepted and cemented that interpretation, making it possible to bring most trademark and unfair competition claims under the Lanham Act. It argues that, while state law has technically played a role in all three periods, it has never really played a significant substantive role, except in some cases in the modern era to broaden the scope of rights beyond the federal statute. In fact, the persistent sense that federal and state law regulate concurrently has masked a significant federalization of trademark and unfair competition law over the last forty to fifty years. The reasons for that federalization deserve some scrutiny. If those reasons are persuasive, then we should question any continuing role for state trademark law.
Illyrians in Cymbeline

AbstractThis essay explores the implications of Cymbeline's two references to the Illyrian peoples, named as the Pannonians and Dalmatians, for Shakespeare's portrayal of ancient Britain and its position of political and cultural in‐betweenness vis‐a‐vis Rome. In mentioning these peoples of the Roman province Illyricum, Shakespeare alludes to memorable episodes from non‐British history that have gone unnoticed or underappreciated in the criticism of the play, although they speak to the playwright's general curiosity about Roman history as well as his knowledge of the geographically distant but discursively familiar Illyrian peoples. Important parallels between the historical accounts of the Pannonians and Dalmatians and of the ancient Britons allow Shakespeare to explore the effects of Romanization on native populations that appear to share “national” characteristics and political and military fortunes. The play thus highlights mixed identities produced in an unstable space between Britishness and Romanne...
Weight functions and fundamental fields in layered media

Abstract A variational principle introduced by Sham to determine elastic fields with unbounded strain energy in finite homogeneous bodies is extended to piecewise homogeneous bodies. It is shown that the modification involves only an additional known body force like term in the functional. The resulting displacement-based finite element method determines the weight functions for all three fracture modes and for both traction and displacement boundaries in a unified manner. Numerical examples for two-dimensional cracks in layered isotropic bodies are presented.
Beta blocker toxicity after overdose: When do symptoms develop in adults?

Published reports of beta blocker ingestions in adults are retrospectively reviewed to determine at what point postingestion symptoms develop. Thirty-nine symptomatic beta blocker ingestions were found. The patients ranged from 14 to 67 years of age. Thirty-one (80%) of those who demonstrated symptoms did so within 2 h of ingestion. This number rose to thirty-eight (97%) by 4 h postingestion. Only one patient developed symptoms after more than 4 h of asymptomatic observation. The development of bradycardia and first degree atrioventricular block during observation appeared to predict toxicity in this patient who suddenly developed hypotension 6 h postingestion. No patient required treatment for delayed cardiovascular depression if they remained asymptomatic during a 4-h period of observation postingestion and demonstrated a normal electrocardiogram throughout. Whether the risk of delayed onset of toxicity after 6 h of asymptomatic observation is sufficiently low to warrant "medical clearance" requires further investigation.
Estimation of the Timing of Perinatal Transmission of HIV

Knowledge of the timing of perinatal transmission of HIV would be valuable for the determination and evaluation of preventive treatments and would shed light on the mechanism of transmission. Estimation of the distribution of the time of perinatal transmission is difficult, however, because tests of infection status can only be undertaken after birth. DNA and RNA polymerase chain reaction (PCR) assays and HIV culture have been the most commonly used diagnostic tests for perinatal HIV infection. Such tests have high sensitivity and specificity, except when they are given shortly after infection. In this paper we use the time-dependent sensitivity of these diagnostic tests to make nonparametric and semiparametric inferences about the distribution of the time of perinatal HIV transmission as well as the cumulative probability of perinatal transmission. The methods are illustrated with data from a clinical trial conducted by the AIDS Clinical Trials group.
Objectives of hedging and optimal hedge ratios: US vs Japanese investors

Abstract Assuming interdependence vs independence of the equity and currency markets, the hedging performances of the minimum-total return variance hedge (MTRVH) vs the minimum-return differential variance hedge (MRDVH) strategies are compared. Substantial interdependence between the two markets is observed. The MTRVH ratios yield the best risk/return tradeoffs in all cases, and they are smaller than the MRDVH ratios. The currency volatility ratio is introduced as an indicator of a natural hedge. The Japanese and US investors have potential to make gains from global diversification and currency hedging, but the Japanese investor benefits more than the US investor does. More hedging is needed for the Japanese investor due to the strong yen, some positive covariances and negative currency surprises.
The operating microscope in the management of melanotic neuroectodermal tumor of infancy

Melanotic neuroectodermal tumor of infancy is a rare condition that is most commonly found within the head and neck regions. We present a 4-month-old boy with a melanotic neuroectodermal tumor of infancy of his maxilla. Because of the fairly high recurrence rate, the operating microscope was used after surgical excision to remove unseen remnants of the pigmented lesion. The patient has been followed for 4 years without signs of recurrence.
Additional Reductions In Medicare Spending Growth Will Likely Require Shifting Costs To Beneficiaries

Policy makers have considerable interest in reducing Medicare spending growth. Clarity in the debate on reducing Medicare spending growth requires recognition of three important distinctions: the difference between public and total spending on health, the difference between the level of health spending and rate of health spending growth, and the difference between growth per beneficiary and growth in the number of beneficiaries in Medicare. The primary policy issue facing the US health care system is the rate of spending growth in public programs, and solving that problem will probably require reforms to the entire health care sector. The Affordable Care Act created a projected trajectory for Medicare spending per beneficiary that is lower than historical growth rates. Although opportunities for one-time savings exist, any long-term savings from Medicare, beyond those already forecast, will probably require a shift in spending from taxpayers to beneficiaries via higher beneficiary premium contributions (o...
The prospects for genetic improvement

(1956). The prospects for genetic improvement. Eugenics Quarterly: Vol. 3, No. 1, pp. 32-37.
Postoperative intramyocardial abscess caused by mucormycosis

Abstract We report the case of an intramyocardial abscess caused by mucormycosis thai arose after cardiac operation. Several causes of immunosuppressiun in a 71-year-old woman were exacerbated after she underwent coronary revascularization. Before she died of multiple organ system dysfunction, a variety of supraventricular and ventricular arrhythmias, as well as complete heart block, developed, but the cause was not clear until autopsy revealed a large septal myocardial abscess due to mucormycosis.
Dynamic Capabilities and Performance of Meeting Planners

ABSTRACT As a new strategic management approach, dynamic capabilities theory leads meeting planners to adapt to rapidly changing environments in order to generate better performance and gain competitive advantages in the industry. Previous studies in management focused on dynamic capabilities of organizations, but this present study focuses on dynamic capabilities of individual meeting planners. The purpose of this present study is to determine key abilities that lead to dynamic capabilities of meeting planners, and to examine the relationship between the dynamic capabilities and job performance of meeting planners. Findings confirmed that resource reconfigurability and knowledge management were key abilities in dynamic capability, which directly impact job performance. This present study offers insight into how competitive advantage of meeting planners is achieved. Implications of the findings for theory and future research are discussed.
Effects of incentives and primary and secondary group interaction on learning a complex maze.

ond. The friendship or primary group has been defined as "one in which members are predisposed to enter into a wide range of activities; and their predisposition to do so is associated with a strong predominance of positive affect" (Bates & Babchuck, 1961). The above dimension of the concept of primary group may be considered analogous to the concept of group cohesiveness, defined as ". . . the resultant of forces which are acting on members to stay in the group" (Festinger, eJ al., 1948). Thus cohesiveness can be assumed to be a quality that is part of the essence of the primary group. Back (1951) in a study of the cohesiveness-attraction within groups found that the greater the cohesiveness, the greater the power of the group to influence its members in the direction of the group's goals. Consequently, it appears that the interactions of primary (cohesive) groups should have more positive effects on achievement of the group's goals than the interactions of secondary groups. Thus it was hypothesized that individuals in primary groups who, between successive trials of a complex movement task, interact with the purpose of improving either individual or group performance, would evidence a significantly higher level of motor learning than individuals in secondary groups. Cratty and Sage (1964) studied the effects of the interactions of primary and secondary groups on the learning of a locomotor maze. They also compared the learning of interacting members of groups with that of individuals. While they found differences between groups and individuals, the expected differences between primary and secondary groups were not evidenced. This finding was probably due to the fact that, in the primary groups, interaction regarding the task tended to decline in favor of non-task-oriented conversation. Missing for the primary groups was the motivation, or more properly, the incentive1 to limit interaction to the question of the task. It was decided that 'It is contended that incentive is differentiated from motivation in that motivation is driveoriented, and, as such, is not as conscious or voluntary (Deese, 1958).
Declining tree stocks in African countries

Abstract The paper first discusses evidence of the loss of tree stocks in farming regions of Sub-Saharan African countries, and the associated ecological changes taking place. The second part discusses the economic merits and limitations of two forms of public investment in afforestation: (i) in forestry management and plantation programs, with special reference to watershed and shelterbelt plantings, and (ii) in various forms of support — research, extension and nurseries — for the development of agro-(or farm-)forestry. In areas where tree stocks are becoming seriously depleted, the ecological and economic benefits would be significant for both types of investment. Shelterbelt and watershed plantings have the advantage of having well-defined effects, but are limited in scope by their relatively large budgetary and labor requirements. It is widely acknowledged that they would need to be complemented by agro-forestry development programs. By involving the farmers themselves in tree planting and stabilization of soils, the development of agro-forestry practices in Africa would offer prospects of a major increase in afforestation rates at significantly lower budgetary costs per hectare of farmland protected. However, the risks and difficulties of obtaining a good farmer response are not small and success would depend on economic policies that were far more favorable towards investment in agriculture and natural resources than they have been so far in the region.
Quantum transport in microstructures

Abstract Advanced microfabrication techniques allow production of experimental systems as narrow as 20 nm for study of electron transport at low temperatures, ~1K. Fine wires in metals, Si-MOS inversion layers, and GaAs modulation-doped heterostructure layers have been studied. Metal rings of diameter ~1 μm have also been studied. New electron interference effects have been discovered in these systems, due to electron partial waves which scatter elastically from impurities. The length scale over which these interference effects occur is the phase coherence length, ¢ φ , of order 1 μm or greater at 1K. In this paper the physical mechanisms and manifestations of these electron interference effects are reviewed. The microfabrication methods used to produce these ultrasmall structures are also reviewed. Other quantum transport issues, including inelastic scattering mechanisms, detection of single trap states, and wavefunction spatial quantization, are also discussed.
Update of results of autologous bone marrow transplantation in lymphoma

A substantial proportion of patients with Hodgkin’s disease and non-Hodgkin’s lymphoma will fail to achieve a complete remission with initial chemotherapy or will relapse after attaining a complete remission. The results of conventional salvage chemotherapy regimens for these patients have been disappointing. This has led to the use of highdose therapy regimens which can be administered with the use of hematopoietic rescue (bone marrow transplantation). The use of bone marrow transplantation for patients with relapsed and refractory lymphoma has increased rapidly. Data from the North American Autologous Bone Marrow Transplant Registry indicate that approximately 40 % of autologous bone marrow transplants are being performed for patients with lymphoma. Several large series of transplantation for Hodgkin’s disease and non-Hodgkin’s lymphoma have been published in the last two years1-12. The results of these series vary widely due to differences in patient selection and pre-transplant prognostic factors. Differences in supportive care and preparative regimens prior to transplant may also account for the wide range of outcomes reported after transplantation. Although these differences make it impossible to compare results of one series with another, it is clear that a significant proportion of patients can achieve long term disease free survival following high dose therapy with marrow transplantation. It is also important, however, to note that this form of therapy can be associated with substantial morbidity and mortality. Transplant-related mortality exceeds 20 % in some series. However, greater experience, better patient selection, and advances in supportive care, such as hematopoietic growth factors, are allowing many institutions to perform transplantation with mortality rates under 5 %.
The phage SPO1-specific RNA polymerase, E.gp28, recognizes its cognate promoters in thymine-containing DNA

The bacteriophage SPO1 gene 28-encoded protein, gp28, directs specific recognition of viral middle promoters in hydroxymethyluracil-containing DNA by the Bacillus subtilis host's RNA polymerase core. Using appropriately sensitive methods of detection, we have shown that discrimination against thymine-containing DNA is not absolute and that the gp28-containing RNA polymerase precisely initiates transcription at two thymine-containing SPO1 middle promoters.
Variability of Internal Geometry of Duplexes: ABSTRACT

Duplexes are imbrications of the footwall of a thrust fault (or series of connected thrust faults) in which the minor faults connect to or intersect with the master thrust surface at both their leading and trailing edges. Within this closely constrained definition, there is considerable geometric variation. The current classification scheme recognizes the variation in postdeformational arrangement of horses in two dimensions, but ignores variations in the size and shape of the horses and in the displacement on the imbricate fault surfaces. Compilation of the geometric arrangement of horses in known duplexes shows that such variations are common and result in several geometric variations that do not fit into the current classification. Additional geometric variations can b found in 3-dimensional framework. These geometric variations can be correlated with mechanical properties of the footwall material in which the duplex formed. Since the deformational style within the horses is also controlled by the same mechanical factors, the internal structure of the horses can be correlated with the gross geometry of the duplex. Recognition of the range of duplex geometries and the correlation with deformational patterns should aid exploration in complex thrust belts. End_of_Article - Last_Page 538------------
Alopecia Areata and Comorbid Conditions Should We Screen Patients?: Comment on “Autoimmune, Atopic, and Mental Health Comorbid Conditions Associated With Alopecia Areata in the United States”

Comorbidity is an emerging issue in dermatology, with increasing evidence that common dermatological diseases, such as psoriasis, can be associated with systemic conditions that severely affect patients� health and even their life expectancy. The study reported by Huang and coworkers1 in this issue shows that alopecia areata (AA) is commonly associated with autoimmune diseases, atopic dermatitis, and psychiatric problems. This is not new information; most of these associations have been well known for more than 50 years. In 1963, Muller and Winkelmann2 published in this journal a retrospective study of 736 patients with AA seen at the Mayo Clinic from 1945 to 1954. Comparing the results of the 2 studies, we see the same comorbid conditions reported, even if the prevalence is considerably higher in the current study for most conditions, as follows: atopy, 11% for Muller and Winkelmann2 vs 38.2% for Huang et al1; psychiatric disorders, 18% vs 25.5%; thyroid diseases, 8% vs 14.6%; diabetes mellitus, 2% vs 11.1%; vitiligo, 4% vs 2.8%; collagen diseases, 2% vs 8.2%; and ulcerative colitis, less than 1% vs 6.3% for inflammatory bowel disorders.
Ventricular free wall and septal rupture (double rupture): a "pseudocomplication" during post-infarction laser angioplasty.

We report the rare occurrence of double rupture of the myocardium occurring immediately following successful laser recanalization of an occluded right coronary artery in a 72-year-old woman 5 days following infero-posterior myocardial infarction. © 1993 Wiiey-Liss, Inc.
Ophthalmic manifestations of IgG4-related disease: single-center experience and literature review.

Abstract Objectives IgG4-related disease (IgG4-RD) is an inflammatory disorder responsible for fibrosing, tumefactive lesions that can involve the lacrimal gland as well as the extraocular muscles, orbital soft tissues, sclera, and local nerves. We reviewed IgG4-related ophthalmic disease (IgG4-ROD), including the natural history, pathology, and treatment, based on our center's experience and that reported in the literature. Methods We identified 27 patients with orbital manifestations from our IgG4-RD registry; six were excluded because no pathology was available for review. All 21 cases included had histopathologically confirmed diagnoses of IgG4-RD, 11 of which were of the orbital tissue. Other data were obtained by a retrospective medical records review. MEDLINE and PubMed literature searches in English were conducted to identify articles for a literature review on the topic. Results Patients with IgG4-ROD were predominantly male (57%) and had an average age at symptom onset of 50 years (range: 21–79 years). The lacrimal gland was the most commonly involved structure (62%). Most patients (71%) had bilateral disease and extra-orbital involvement (71%); these patients also had elevated serum IgG4 concentrations compared to those with unilateral disease and no extra-orbital disease. Ten patients improved following rituximab treatment. Conclusions Ophthalmic involvement is a common manifestation of IgG4-RD and can affect nearly every orbital structure. Consideration of IgG4-RD and accurate diagnosis by biopsy have important implications for prognosis and treatment following the distinction of this condition from the Sjogren syndrome (SjS), granulomatosis with polyangiitis (GPA, formerly Wegener's), sarcoidosis, lymphoma, infection, and other disorders. Rituximab holds promise as an effective steroid-sparing agent or therapy for steroid-resistant cases.
Cerebral lateralization in young children as measured by dichotic listening and finger tapping tasks

Abstract Evidence of cerebral lateralization was found in children of 3, 4, and 5 yr of age, A dichotic listening experiment revealed a right ear advantage for verbal stimuli and a left ear advantage for nonverbal stimuli in children at these ages. During the finger tapping experiment, secondary tasks (reciting and humming) reduced both left and right index finger tapping rates. However, reciting disproportionately reduced tapping on the right while humming disproportionately reduced tapping on the left finger in each of the three age groups. The asymmetry of function revealed in both experiments suggests that the left hemisphere is in some sense specialized for verbal functions, and the right hemisphere for nonverbal functions by the age of 3.
Relationships Between Perceived Attributes of Innovations and Their Subsequent Adoption.

(1978). Relationships between perceived attributes of innovations and their subsequent adoption. Peabody Journal of Education: Vol. 55, No. 4, pp. 332-336.
Activation of a specific vestibulo-olivary pathway by centripetal acceleration in rat

Abstract Unanesthetized Long-Evans (pigmented) rats were subjected to 2.0G centripetal acceleration for 90 min. Immunohistochemical analysis, using a polyclonal antibody for Fos, revealed a distinct pattern of neuronal activation in the off-axis animals in the dorsomedial cell column (DMCC) of the inferior olivary nucleus. These results are consistent with previous anatomical evidence and indicate that the DMCC is an important component in an otolith-olivocerebellar circuit which may help to define an internal spatial reference.
A Collaborative Study to Develop a Standardized Food Protein Solubility Procedure

ABSTRACT A colaborative study was conducted to develop a rapid, simple and reliable procedure for determining the solubility of food protein prod- ucts, e.g., spray-dried whey protein concentrate, sodium caseinate, egg white protein and soy protein isolate. The procedure was devel- oped by modifying the nitrogen solubility index (NSI) procedure. Pro- tein content and soluble protein were determined by micro-Kjeldahl or biuret procedures with standard deviations of ? 0.83-4.12 for all proteins except caseinate which had a value of Y? 13.95. Although the biuret and micro-Kjeldahl procedures generally provided comparable accuracy and precision for protein content and solubility of certain proteins, the biuret procedure exhibited considerable error and vari- ability for other proteins. INTRODUCTION COMMERCIAL food protein products are important func- tional ingredients in a number of formulated food products (Kinsella, 1976; Pour-El, 1979; Cherry, 1981; Morr, 1982). These protein products, which are customarily spray-dried, must in most cases provide a high degree of solubility in order to be useful and functional. The solubility of these protein prod- ucts is dependent upon the physicochemical state of their pro- tein molecules, which are either favorably or adversely affected by heating, drying and other processing treatments during their manufacture and storage. Protein solubihty is commonly expressed as water-soluble nitrogen, nitrogen solubility index, water-soluble protein or protein dispersibility index (Wolf and Cowan, 1975). These latter methods utilize different dispersion media and proce- dures and different experimental conditions for recovering and quantitating the soluble proteins. These procedures are gen- erally tedious and time-consuming and are unsatisfactory for routine work. Thus, researchers commonly resort to short-cut solubility methods which frequently fail to correlate well with the physicochemical and functional properties of the protein products @hen, 1976). This collaborative study was undertaken to develop a rapid, convenient and reliable protein solubility procedure that would be suitable for characterizing large numbers of protein prod- ucts. A major objective underlying the development of this procedure was to identify and eliminate sources of variability in the
Two-dimensional acoustic scattering, conformal mapping, and the Rayleigh hypothesis

Methods for solving two-dimensional scattering problems using conformal mappings are investigated. It is shown that their convergence relies on a mapped form of the Rayleigh hypothesis. It is concluded that methods based on conformal mappings offer no advantages over established methods in which the scattered field is expanded as a series of circular-cylindrical outgoing wavefunctions.
The Scope of Latino/a Environmental Studies

This article surveys the development of Latino/a environmental studies over the past decade of research and activism. It addresses issues, concepts, and controversies in four major areas of research including (1) theories and concepts of environmental racism and environmental justice, (2) environmental history and ecological politics, (3) case studies of Latino/a environmental justice movements, and (4) the political ecology of sustainable development. It describes Latino/a contributions to the environmental justice discourse and presents an overview of studies of rural and urban-based social movements. The article identifies gaps in the literature and outlines areas for future research. There is a need for critical studies on the nature of the Latino/a environmental justice movement, on the spatiality of social life, the environmental history of groups other than Chicano/as, and the dialectics of globalization and re-localization.
Dynamic formation of a self-rejecting membrane by nanofiltration of a high-formula-weight dye

Abstract Nanofiltration of a high-formula-weight dye, Cibacron F3G-A, FW=840, was investigated at low-to intermediate-crossflow velocity and pressure using a zirconium hydrous oxide-poly(acrylic acid) membrane. A sharp minimum in the rejection vs. pressure curves obtained at constant crossflow velocities provided a distinct determination of the pressure required to initiate dynamic membrane formation. These minima occurred at a pressure near 2MPa and only at a crossflow velocity less than 0.4 m/s, indicating that a critical pressure is required for membrane formation while also implying that the concentration at the membrane surface is involved in the modification.
Theophylline: Induction of self-biting in rabbits

A tentative animal model is presented for studying the self-mutilating behavior seen in children with an abnormality of purine metabolism. Each of four groups of rabbits was given a quarter-normal diet and daily injections of saline or 46.0, 61.5, or 92.0 mg/kg of anhydrous theophylline (1, 3-dimethylxanthine). The major findings were that (1) the greatest number of self-biters were found in the 61.5 mg/kg group, (2) mortality was directly related to drug dosage, and (3) the onset of biting occurred earliest with the highest dosage.
Sequence analysis and mapping of a novel human mitochondrial ATP synthase subunit 9 cDNA (ATP5G3)

We describe the cloning, sequence analysis, and chromosomal mapping of a novel mitochondrial ATP synthase subunit 9cDNA, P3. Subunit 9 transports protons across the inner mitochondrial membrane to the F1-ATPase protruding on the matrix side, resulting in the generation of ATP. Sequence analysis of the P3 cDNA reveals only 80% identity with the human subunit 9 genes P1 and P2 in the DNA sequence encoding the mature peptide. However, this sequence predicts a mature protein identical to P1 and P2. The predicted sequence of the P3 leader peptide differs from the P1 and P2 leaders, but retains the "RFS" motif critical for mitochondrial import and maturation. The P3 gene (ATP5G3) maps to chromosome 2.
Hydrous pyrolysis of New Albany and Phosphoria Shales: production kinetics of carboxylic acids and light hydrocarbons and interactions between the inorganic and organic chemical systems

Abstract Hydrous pyrolysis in flexible gold-bag autoclaves was used to study the production of carboxylic acids and light hydrocarbons from two marine type IIb source rocks (New Albany and Phosphoria Shales). Kerogen pyrolysis produced significant amounts of the monocarboxylic acids (acetic>propionic>butyric). The gases were dominated by CO 2 and methane, in that order, and progressively smaller amounts of the alkanes (ethane>propane>butane>pentane). Kinetic analyses of production rates for the New Albany Shale suggest mean activation energies (E) of 51–54 kcal/mol for both the light hydrocarbons and acids. Pressure had little effect on measured production rates for either shale over the pressure range investigated. Chemical thermodynamic speciation modeling suggests that in these experiments metal–organic acid anion complexation had little impact on aluminum speciation/solubility, but was important with respect to the alkaline earths.
A 100-kyr periodicity in the flux of extraterrestrial 3He to the sea floor

Most of the helium-3 in oceanic sediments comes from interplanetary dust particles (IDPs), and can therefore be used to infer the accretion rate of dust to the Earth through time. ^3He records from slowly accumulating pelagic clays indicate that the accretion rate varies considerably over millions of years, probably owing to cometary and asteroidal break-up events. Muller and MacDonald have proposed that periodic changes in this accretion rate due to a previously unrecognized 100-kyr periodicity in the Earth's orbital inclination might account for the prominence of this frequency in climate records of the past million years. Here we report variations in the 3^He flux to the sea floor that support this idea. We find that the flux recorded in rapidly accumulating Quaternary sediments from the Mid-Atlantic Ridge oscillates with a period of about 100 kyr. We cannot yet say, however, whether the 100-kyr climate cycle is a consequence of, a cause of, or an effect independent of these periodic changes
Towards trust-aware access management for ad-hoc collaborations

In an ad-hoc collaborative sharing environment, attribute-based access control provides a promising approach in defining authorization over shared resources based on userspsila properties/attributes rather than their identities. While the userpsilas attributes are always asserted by different authorities in the form of credentials, these authorities may not be accepted by the resource owner with the same degree of trust. In this paper, we present a trust-aware role-based authorization framework, called RAMARS_TM, to address both the access control and the trust management issues in such environment. Central to our approach is the dynamic role assignment based on a userpsilas attributes, and trust management, as a special constraint, is in place to make trust decisions on a userpsilas attributes. Required components and functions are identified and specified in our trust and access management policies. An architecture of prototype system implementation is also discussed.