cssi/SciSciGPT-SciSciNet huggingface dataset:
Legislative Approaches of Access to Genetic Resources and Benefit-sharing in Foreign Countries and Their Implications for China

In order to share the benefit arising from the utilization of genetic resources,many mega-biodiversity countries promulgated their laws,based on the Convention on Biological Diversity,to regulate access to genetic resources and benefit-sharing(ABS).In this field,there are four legislative approaches amendment/interpretation,comprehensive legislation,specific legislation,and transnational legislation.Although each approach has its strong point,the trend will be the specific legislation.Namely,the countries shall pass its regulations on ABS and then upgrade it to national law in appropriate time.China should follow this trend.
Inguinal Node Metastases From Testicular Tumors in Patients With Prior Orchiopexy

Testicular tumors in patients who have had the lymphatics disrupted by prior scrotal or inguinal surgery can metastasize primarily to the ipsilateral inguinal nodes in addition to the usual retroperitoneal pattern. Whether routine inguinal node dissection along with retroperitoneal node dissection is warranted in patients with testicular tumors and prior scrotal surgery is controversial due to the small numbers of such cases reported in the literature. We report on 2 patients who had undergone previous orchiopexy and who presented with inguinal and testicular masses. Both patients underwent retroperitoneal lymph node dissection and inguinal node dissection with hemiscrotectomy and metastatic tumor was in each lymphatic area. Ipsilateral inguinal along with bilateral retroperitoneal node dissection should be considered in the primary therapy of any patient with a nonseminomatous testicular tumor who has had prior scrotal and certain inguinal procedures.
A Synthesis of Hepatitis C prevalence estimates in Sub-Saharan Africa: 2000–2013

Hepatitis C (HCV) is a deleterious virus that can be cured with new, highly effective anti-viral treatments, yet more than 185 million individuals worldwide remain HCV positive (with the vast majority un-diagnosed or untreated). Of importance, HCV is a leading cause of chronic liver disease and liver cancer, especially in Sub-Saharan Africa (SSA) where the prevalence remains high but uncertain due to little population-based evidence of the epidemic. We aimed to synthesize available data to calculate and highlight the HCV disease burden in SSA. Weighted random-effects generalized linear mixed models were used to estimate prevalence by risk cohort, African region (Southern, Eastern, Western, and Central Africa), type of assay used, publication year, and whether the estimate included children. A pooled prevalence estimate was also calculated. Multi-variable analyses were limited to cohort and region specific prevalence estimates in the adult population due to limited studies including children. Prevalence estimates were additionally weighted using the known adult population size within each region. We included more than 10 years of data. Almost half of the studies on HCV prevalence in SSA were from the Western region (49 %), and over half of all studies were from either blood donor (25 %) or general population cohorts (31 %). In uni-variable analyses, prevalence was lowest in Southern Africa (0.72 %), followed by Eastern Africa at 3.00 %, Western Africa at 4.14 %, and Central Africa at 7.82 %. Blood donors consistently had the lowest prevalence (1.78 %), followed by pregnant women (2.51 %), individuals with comorbid HIV (3.57 %), individuals from the general population (5.41 %), those with a chronic illness (7.99 %), and those at high risk for infection (10.18 %). After adjusting for the population size in each region, the overall adult prevalence of HCV in SSA rose from 3.82 to 3.94 %. This meta-analysis offers a timely update to the HCV disease burden in SSA and offers additional evidence of the burgeoning epidemic. The study highlights the need to account for type of cohort and region variation when describing the HCV epidemic in SSA, the need for more studies that include children, as well as the need to factor in such variations when planning public health interventions.
Circular Migration and the Gulf States

In this chapter the authors assess the application of the circular migration framework to the six Gulf Cooperation Council member states of Kuwait, Saudi Arabia, Bahrain, Qatar, United Arab Emirates, and Oman. By some estimations, the six GCC states comprise the third largest migratory destination in the contemporary world, and for decades these states have hosted large transient migrant populations that, in some manner or another, appear to fit the definition of circular migration. Through an analysis of migration to the Gulf States this chapter provides an empirical contribution to the expanding discussion of circular migration. In this chapter the nexus between the Gulf migration system and the circular migration framework is configured around two focal points. After an overview of migration in the Gulf States, the authors first examine the policy frameworks that regulate and govern migration to the GCC. Second, using an ethnographic lens, the authors explore the experiences of the migrants at work in the region. They conclude with a discussion of the implications of promoting the circular migration framework in the region.
Splenic Marginal Zone Lymphoma (SMZL): Clinical Course after Splenectomy. A Single Institution Experience

Abstract SMZL is an indolent B-cell malignancy accounting for 1–2% of chronic lymphoid leukemia found on bone marrow examination and up to 25% of low-grade B-cell neoplasms in splenectomy patients. Aggressive transformation of SMZL rarely occurs. It usually presents as an incidental finding or with symptoms of splenomegaly and anemia. There is still no reliable clinical or biological scoring system for prognostic stratification. We reviewed pathology reports of 41 splenectomized patients at HFHS from 1994 to 2007 and identified 14 patients with splenic marginal zone lymphoma (SMZL). The reasons for splenectomy were symptoms of splenomegaly in all 14 patients, anemia in 13 patients, thrombocytopenia in 12 patients, AIHA in 4 patients, splenic laceration in one patient. We report here the demographics, clinical course and pathology review of these patients. The median age of patients was 77.8 years. There were 7 male and 7 female patients. ECOG performance status was 0–1 in 12(86%), and 2 in 2(14%). Of the 14 patients, 8(57%) were at Ann Arbor stage IV, 1(7%) was at stage III, 4(29%) were at stage II, and 1(7%) at stage I. LDH was above normal in 9(64%) patients B-symptoms were observed in 1(7%). Bone marrow involvement was documented in 8(57%) of the patients. Anemia in 13(93%), thrombocytopenia in 12(86%), AIHA in 4(29%). IPI score was 1–2 in 5(36%), and score 3–4 in 9(64%) of the patients. Median weight of the spleen was 1235 gm. Bone marrow cytogenetics were abnormal in 4(29%) cases. Following splenectomy, cytopenias resolved completely or partially (CR/PR) in 13(93%) patients. Bacterial infections were observed in 4(29%) patients and 2(14%) died of infectious complications. Progressive disease requiring additional systemic therapy was documented in 5(36%) patients. Total of 5(36%) patients died. One secondary to NSLC, 1(7%) of urothelial carcinoma, 1(7%) secondary to hypercalcemia, 2(14%) due to bacterial sepsis. Patients were followed up to 139 months (with median follow-up time of 42 months). The estimated median overall survival (OS) for this group was 116.5 months (9.7 years), the median progression-free survival (PFS) was 91 months (7.6 years). The Kaplan Meier method was used to calculate these estimates. A simple median was calculated for the sample median. In summary, we report the course of 14 patients with SMZL who underwent splenectomy for symptomatic disease. Only 5(36%) required systemic therapy following splenectomy. No death was attributed to progressive SMZL. Overall course was indolent even after splenectomy. Estimated OS was 116.5 months (9.7 years), PFS - 91 month (7.6 years).
Kaybob Revisited: What We Have Learned about Compressor Stability from Self-Excited Whirling

The Kaybob compressor failure of 1971 was an excellent historic example of rotordynamic instability and the design factors that affect this phenomenon. In the case of Kaybob, the use of poorly designed bearings produced unstable whirling in both the low and high pressure compressors. This required over five months of vibration troubleshooting and redesign along with over 100 million modern U.S. dollars in total costs and lost revenue. In this paper, the history of the Kaybob compressor failure is discussed in detail including a discussion of the ineffective bearing designs that were considered. Modern bearing and rotordynamic analysis tools are then employed to study both designs that were considered along with new designs for the bearings that could have ultimately restored stability to the machine. These designs include four-pad, load-between-pad bearings and squeeze film dampers with a central groove. Simple relationships based on the physics of the system are also used to show how the bearings could be tuned to produce optimum bearing stiffness and damping of the rotor vibration, producing insights which can inform the designers as they perform more comprehensive analyses of these systems.
Usual Consumption of Specific Dairy Foods Is Associated with Breast Cancer in the Roswell Park Cancer Institute Data Bank and BioRepository.

Background : Dairy foods are complex mixtures which include nutrients and non-nutrient substances that could potentially influence cancer etiology, including breast cancer. Objective: The purpose of this study was to examine associations between the types and quantity of dairy foods consumed and the risk of breast cancer among women participating in the Roswell Park Cancer Institute Data Bank and BioRepository (DBBR) between 2003 and 2014. Methods: Archived clinical and questionnaire data were obtained from the DBBR from 1941 women diagnosed with breast cancer between December 2003 and October 2014, and 1237 control participants. Intakes of dairy foods were queried with a self-administered food-frequency questionnaire and grouped into monthly intakes of total dairy, milk, yogurt, low-fat cheese, other cheese, and sweet dairy. ORs and 95% CIs were estimated with unconditional logistic regression adjusting for age, race, body mass index, menopausal status, energy intake, type of milk usually consumed, cigarette smoking status, and family history of breast cancer. Results: Total dairy intakes were associated with a non-significant 15% reduction in breast cancer risk ( P = 0.11). Higher intakes of yogurt were associated with reduced risk of breast cancer (OR: 0.61; 95% CI: 0.46, 0.82) and higher intakes of American, cheddar, and cream cheeses were associated with a marginally significant increased risk (OR: 1.53; 95% CI: 0.99, 2.34; P = 0.05). Associations with dairy foods were mixed when stratified by estrogen receptor (ER) status, and in general reflected those of overall breast cancer. However, we observed positive associations between milk intake and risk of ER− breast cancer (OR: 1.58; 95% CI: 1.05, 2.37) and inverse associations between sweet dairy and ER+ breast cancer (OR: 0.52; 95% CI: 0.29, 0.95). Conclusions: Specific dairy foods may contribute to breast cancer risk in women, although the risk varies by source of dairy. Future studies are warranted to confirm the protective potential of yogurt in this type of cancer.
Regulated methionine oxidation by monooxygenases

Protein function can be regulated via post-translational modifications by numerous enzymatic and non-enzymatic mechanisms, including oxidation of cysteine and methionine residues. Redox-dependent regulatory mechanisms have been identified for nearly every cellular process, but the major paradigm has been that cellular components are oxidized (damaged) by reactive oxygen species (ROS) in a relatively unspecific way, and then reduced (repaired) by designated reductases. While this scheme may work with cysteine, it cannot be ascribed to other residues, such as methionine, whose reaction with ROS is too slow to be biologically relevant. However, methionine is clearly oxidized in vivo and enzymes for its stereoselective reduction are present in all three domains of life. Here, we revisit the chemistry and biology of methionine oxidation, with emphasis on its generation by enzymes from the monooxygenase family. Particular attention is placed on MICALs, a recently discovered family of proteins that harbor an unusual flavin-monooxygenase domain with an NADPH-dependent methionine sulfoxidase activity. Based on structural and kinetic information we provide a rational framework to explain MICAL mechanism, inhibition, and regulation. Methionine residues that are targeted by MICALs are reduced back by methionine sulfoxide reductases, suggesting that reversible methionine oxidation may be a general mechanism analogous to the regulation by phosphorylation by kinases/phosphatases. The identification of new enzymes that catalyze the oxidation of methionine will open a new area of research at the forefront of redox signaling.
Predictors of early treatment failure following initial therapy for systemic immunoglobulin light-chain amyloidosis.

We analysed factors predicting early treatment failure (ETF), after first-line therapy for light-chain amyloidosis (AL). AL amyloidosis patients seen at Mayo Clinic within 90 days of diagnosis, from 2006 to 2015, excluding those who died within 3 months of initial therapy, were analysed retrospectively. ETF was defined as progression requiring treatment change or death within 12 (ETF12) or 24 (ETF24) months of first-line treatment. Non-ETF included those with a follow-up of more than 12 or 24 months who had progression beyond 12 or 24 months. A total of 724 patients met the study criteria; 244 (33.7%) had ETF12 and 388 (53.6%) had ETF24. Patients with ETF12 were older (64.1 vs. 62.2 years) with higher prevalence of cardiac (81 vs. 64.1%) and multi-organ involvement (67.2 vs. 45.4%) and higher proportion of patients with t(11; 14) (58.5 vs. 44.3%) or in higher Mayo 2012 stage (58.5 vs. 41.1%).The median follow-up was 5.4 years from start of initial therapy. In multivariate analysis, presence of t(11; 14) and non-incorporation of autologous transplant in initial therapy are significant predictors of ETF12 (p = .01and p = .003) and ETF24 (p = .0001 and p = .005) while Mayo stage is predictive of ETF24 (p = .002), but not ETF12.
Abstract 1154: Targeted silencing of elongation factor 2 kinase (EF2K) suppresses invasion, cell proliferation and growth in an orthotopic model of ovarian cancer

Ovarian cancer (OCa) is one of the most aggressive and deadliest cancer and is currently incurable disease with the poorest prognosis and survival rates (4%, 5year survival rates). One of the hallmarks of OCa is its early invasion and metastasis, resistance to chemotherapeutics and radiotherapy and aggressive tumor progression. These features contribute to a poor prognosis of this highly complex malignancy with many molecular alterations and mutations involving multiple genes. The major reason for patient death is due to metastasis and resistance to current therapies that include chemotherapy, hormonal therapy and radiation. Therefore, novel molecular targets and therapeutics strategies are urgently needed to enhance the efficacy of current therapies and prolong patient survival. Recently, we discovered that Eukaryotic elongation factor-2 kinase (EF2K), an atypical kinase, is dramatically up-regulated in cells and promotes cell survival and proliferation, its inhibition significantly reduces cell growth and colony formation. However, the role that EF2K in OCa and pathways regulating cell proliferation, colony formation, survival, invasion/metastasis and resistance remains is largely unknown. Here, we show that specific inhibition of EF2K by siRNA-mediated knockdown markedly inhibits OCa (HeyA8 and SKOV3ip1) cell proliferation, colony formation and invasion/migration in vitro. This targeting resulted in a substantial decrease in eEF2 phosphorylation in the tumors, and led to the inhibition of tumor growth and metastasis. Lack of function demonstrated that EF2K regulates Beta1-integrin, p-SRC, p-FAK, p-AKT, p-IF2alpha, p-ERK expression. Our western blot data suggested that EF2K may enhance tumorigenesis and metastasis through the upregulation of pro-tumorigenic, metastatic proteins and pathways in OCa. Furthermore, we found that therapeutic inhibition of EF2K by systemically administered (i.v) nanoliposomal EF2K siRNA inhibited growth SKOV3 tumor xenografts and intraperitoneal tumor nodules (intraperitoneal metastatic model) in nude mice (p Citation Format: Mumin Alper Erdogan, Bulent Ozpolat. Targeted silencing of elongation factor 2 kinase (EF2K) suppresses invasion, cell proliferation and growth in an orthotopic model of ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1154. doi:10.1158/1538-7445.AM2017-1154
Improvement in Quality of Life in Patients with Moderate to Severe Psoriasis Treated with Adalimumab or Ustekinumab

Introduction:Quality of life (QoL) is an important issue in psoriatic disease that should be included when assessing therapeutic efficacy of treatments. The objective of this study was to compare i...
AnS 490-H: Part I; Building a Portable Environmentally Enriched Wagon for a North American Porcupine

The objective of this project was to design and construct a portable environmentally enriched wagon for a North American Porcupine with the intent for it to be used during educational presentations at the Omaha Henry Doorly Zoo and Aquarium. The wagon design was built using SolidWorks. A nine-step process was developed to build the wagon: (1) cut the boards to proper length and secure with corner braces (2) place border around primary and secondary platforms (3) add casters to primary boards and pegs to secondary board (4) connect U-brackets to board underside for dowels to fit (5) cut and add plastic base to boards (6) place cork tiles on secondary board (7) secure tree trunk and branches to primary board (8) secure hide next to tree (9) add woodchips to primary board. It took approximately 53 hours with two persons to construct the wagon and cost ~$63. In conclusion, the construction of the portable environmentally enriched wagon was successful. It was cost friendly and completed within the desired time frame.
Patience Clever’s exciting voyage through the world of matrices and challenging analyses

The calibration curve for iron did not look good (Fig. 7.1). The absorbance axis intercept was negative and the calibration curve was concave. The precisions for the blank were not very good (see Tab. 7.1). Patience gazed at the printout of the determinations, took off her glasses and looked at Frank who seemed to be unhappy. “I checked all instrument parameters. The intensity is o.k., the characteristic mass is o.k., there is almost no background absorbance and yet the reproducibility is lousy and an adequate calibration almost impossible. We definitely cannot guarantee a 0.5 μg/L, detection limit for this analysis!”. Patience chuckled “If you could see yourself now Frank, you would agree that you look fairly silly at the moment. Had you looked at the individual repetitions carefully, you would have seen the problem you are up against. The good news is that I think I know pretty much what the problem is. Now comes the bad news: it will be really tough to get it under control.” Frank indeed was puzzled. Can you help him to understand his data?
DYSON ANALYSIS OF GRAVITON PRODUCTION, LIGO, AND THE GERTSENSHTEIN EFFECT

In a 2013 paper, Freeman Dyson presented thought experiments challenging the detectability of gravitons via LIGO interferometry and via the Gertsheshtein effect. Dyson assumed a distance of several light years would be required for detection of the interaction between gravitational waves (GWs) and tenuous B fields and photons, making gravitons experimentally unverifiable. In this paper, we present contrary theoretical evidence for detectability of near-field interaction of gravitons, photons, and a magnetic field. Our first example of 100% probability of the Gertshenshtein effect working is due to a GW generated by a Tokamak with a interaction of GW, B field, and photons, in a volume on the order of a few cubic meters. We furthermore outline how Dyson was giving misleading information on the efficiency of LIGO, which is inimical to that research initiative on gravitational wave still very pertinent to essential gravitational physics, via the interferometer arrays, which has been noted and corrected
More Thoughts About Conceptual Models and Literature Reviews: Focus on Population Health:

This essay extends discussion of the ways in which a conceptual model of nursing can guide literature reviews. Emphasis is placed on ways in which the conceptual model of nursing and population health was used to guide and/or categorize the results of scoping reviews of the literature. Examples are presented in the form of diagrams and narrative explanations of the resultant conceptual-theoretical-empirical structures.
Standards Collections: Considerations for the Future

Technical standards are a form of gray literature that describe consensus for a wide variety of applications. They promote safety, quality, and interchangeability of parts. In academic libraries, s...
Breast Cancer During Pregnancy

Pregnancy-associated breast cancer is uncommon and presents unique challenges for the treating physician. Ultrasound should be performed for the evaluation of a breast mass discovered during pregnancy, although mammography can be obtained with proper fetal shielding. Biopsy of suspicious lesions should be performed. Surgery is safe during any stage of pregnancy and can consist of either mastectomy or breast-conservation therapy. Axillary staging is generally performed with axillary lymph node dissection, although sentinel lymph node biopsy can be performed without the use of blue dye, which is contraindicated in pregnancy. However, the accuracy of sentinel lymph node biopsy during pregnancy is not well established. Radiation therapy should be delayed until after delivery due to risk of fetal exposure. Chemotherapy is contraindicated during the first trimester of pregnancy. In addition, some chemotherapeutic agents are contraindicated during any stage of pregnancy. Neoadjuvant chemotherapy can be given to allow for breast-conservation therapy to be performed and also to allow for radiation to be delayed until after delivery.
Molecular-Level Insight into CO2 Adsorption on the Zirconium-Based Metal–Organic Framework, UiO-66: A Combined Spectroscopic and Computational Approach

Carbon dioxide (CO2) capture and separation in sorbent materials relies on the interactions that take place between guest molecules and topological or chemical features of the sorbent. Although researchers have developed an immense library of metal–organic framework (MOF) designs, which range in shape, size, and chemical functionality, a molecular-level understanding of how MOF structure and functionality affect capture and transport has yet to be fully achieved. In this work, in situ infrared spectroscopic techniques, coupled with density functional theory, were used to provide insights into the binding locations and energetics of CO2 on the zirconium-based MOF, UiO-66. Two unique CO2 binding motifs in UiO-66 were identified through differing vibrational frequencies of the asymmetric OCO stretching mode. One configuration is established through hydrogen bonding with μ3-OH groups on the MOF nodes, and a second binding mode exists where CO2 is stabilized through dispersive interactions. Variable temperatur...
Treatment of Essential Tremor: Medical Therapy

Essential tremor [ET] is characterized by the gradual onset of tremor in both upper limbs evident during maintenance of posture and with movement. It may also affect the head or voice. Essential tremor is often familial (autosomal dominant) and usually improves temporarily with alcohol. Treatment is indicated when the tremor interferes with functioning, typically dexterous tasks such as writing, or when it is a source of psychological distress causing embarrassment. The first-line drugs for tremor of the upper limbs are propranolol and primidone either alone or combined; they usually offer little relief for bothersome tremor of the voice or head, both of which can be treated with botulinum toxin. For disabling limb tremor unresponsive to maximal medical therapy, deep brain stimulation should be considered.
Summary: Order and Disorder in Brains and Behavior.

The 83rd Cold Spring Harbor Symposium on Quantitative Biology on Brains and Behavior: Order and Disorder in the Nervous System explored the tremendous recent progress in neuroscience and how these advances may be used to improve brain health and address psychiatric and neurological disorders. The Symposium explored a vast array of topics from cell types to cognition. My summary focuses on a few emerging themes. Innovative techniques were ever-present, opening up new experimental possibilities. The commoditization of many state-of-the-art technologies is pushing neuroscience beyond its artisanal ways. Another important theme was "circuits in the middle": Numerous presentations dissected links to cell type-specific circuits that connect different levels of analysis from molecules to behavior. These new technologies have enabled curiosity-driven investigations in animals to connect more directly with preclinical and clinical studies of human brain disorders. Numerous emerging approaches were presented in human neuroscience, bolstering the hope that circuit-specific manipulations will soon provide improved treatments for brain disorders.
Randomized Controlled Trial of a Novel Video-enhanced Advanced Airway Curriculum for Pediatric Residents*

BACKGROUND: Neonatal endotracheal intubation is an ACGME requirement in pediatric residency, and training in non-neonatal intubation is encouraged. Available data suggest that pediatric residents complete training without becoming competent in endotracheal intubation. With limited clinical opportunities for trainees to perform intubation, innovative strategies for instruction are needed. OBJECTIVE: To investigate the impact of a novel curriculum integrating recordings of patient intubations obtained with a videolaryngoscope on pediatric trainees’ intubation performance as measured in a simulated environment. METHODS: We conducted a blinded, randomized controlled educational intervention trial for pediatric interns between January …
Applying the Rasch Model to the University of Rhode Island Change Assessment

Purpose: Measuring readiness for change is an important part of the treatment planning process for individuals with addiction and co-occurring disorders. The University of Rhode Island Change Assessment (URICA) is a commonly used instrument in conjunction with motivational interviewing and has been endorsed by federal and several state substance abuse agencies. This study provides an alternative to classical test theory in determining the extent to which the URICA measures the complex concept of motivation for change in determining the stage of change of participants.Method: The Rasch model analysis was used to determine model-fit of the URICA in measuring motivation for change among participants (N=256) in a web-based recovery program.Results: The URICA did not exhibit model-fit. Items do not provide a step-wise difficulty level in measuring motivation for change. Category responses did not support a clear distribution between categories and responses.Discussion: Findings suggest that significant adaptations to the instrument are needed to ensure the specificity of items and discrete endorsement of more specific motivational factors among individuals seeking aftercare services.Conclusion: It is vital that social workers utilize standardized measures to support clinical decision-making. While the URICA is a commonly used instrument to measure motivation for change, the Rasch analysis supported findings from other analyses that the URICA failed to adequately predict motivation for change among participants.
Assistive Robotics and Muscular System Modeling for Rehabilitation of Spasticity Patients

The use of robotic rehabilitation systems allows specialists to decide on objective measures of patient progress, allowing them to program a personalized training plan. Thus, the use of assistive robotics provides individuals with rehabilitation and restoration of motor functions, if not totally, at least in part, which directly impacts their quality of life. In this work models are used to simulate muscle dynamics using EMG sensors.
In-Band Communications for DC Microgrids

DC microgrids contain DC power sources, storage, and loads. These microgrids use low data-rated communication to manage the DC voltage and current. The student engineering team have simulated and tested an in-band communications mechanism for use on unshielded DC power wires. This mechanism uses transceivers designed for unlicensed wireless communication using deliberately reduced signal power, in order to minimize radio frequency interference. The results of this work will be contributed to relevant IEEE 2030.10 and Open DC Grid standards.
Three‐dimensional cardiac print assisted percutaneous closure of left ventricular pseudoaneurysm in patient with Behçet's disease

Spontaneous left ventricular pseudoaneurysms are very rare and can have catastrophic consequences if unrecognized. A case of combined spontaneous left ventricular aneurysm and pseudoaneurysm in Behcet's disease (BD) has been reported. The case emphasizes advanced techniques for percutaneous closure of the defects with the use of an ex-vivo three-dimensional cardiac printed model as a tool to facilitate the procedure.
WOMEN AT THE LEVEL OF MANAGEMENT, AGENCY CONFLICT MECHANISMS, AND FINANCIAL PERFORMANCE

This study analyzes the effect of female representation in top management, agency conflict mechanism on firm performance in Indonesia Manufacturing Firms. Agency conflict in this reseach consist of managerial ownership, institutional ownership, and debt. The sample of this study consist of 90 manufacturing firms over the period 2013-2017. This study measures firm performance with return on asset and return on equity. Data on this research were analyzed using multiple regression. This study found that female representation in top management and managerial ownership do not affect firm performance. This study also found that institutional ownership positively affects the firm performance and debt negatively affects the firm performance
Modelling, Simulation, and Implementing ROS for Autonomous Navigation of Tracked Robot

This paper presents autonomous navigation and its implementation based on Robotic Operating System (ROS) for a non-holonomic autonomous tracked robot, whereas it handles a full design, implementation, dynamic modeling, and kinematic modeling of the robot. This paper applies robot localization using Adaptive Monte Carlo Localization (AMCL) which uses a particle filter to track the pose of a robot against a known map. It also uses mapping based on the mapping package. It provides laser-based SLAM (Simultaneous Localization and Mapping) mapping. The LIDAR is used to create a 2-D occupancy grid map. Path planning is established using the Dijkstra algorithm to plan a path to a goal position, using a persistent map created by the robot during the mapping process. Also, the robot was equipped with a camera module for image processing and detection of different objects for security purposes. The proposed system shows its capability for adaptation to road segments of different curvatures and the transitions between them.
Dating Violence Victimization Among Adolescent Girls in the American Rural South

Research has shown that girls in rural contexts are more likely to experience dating violence victimization than peers in urban or suburban ones. Yet, little research has been carried out on rural adolescent girls in regard to the outcomes of such dating violence and the role of parenting. The current study tested the link between dating violence victimization (both general and sexual violence victimization) and internalizing problems (depression, anxiety, and low self-esteem), and whether maternal peer approval conditioned this relationship. Cross-sectional data were collected from 335 adolescent girls (Mage = 15.77 years; SD = 1.12) in the American rural South. Results provided evidence that maternal peer approval moderated the relationships between general victimization and low self-esteem, sexual violence victimization and low self-esteem, as well as sexual violence victimization and depression. In addition, adolescent girls with higher levels of maternal peer approval were at greater risk for internalizing problems, following dating violence victimization. Findings provide paradoxical evidence in that high autonomy granting behaviors by parents, trusting daughters to make good decisions about romantic relationships, which might also mean less parental knowledge or monitoring, was associated with greater victimization and associated internalizing problems. Future studies need to replicate this finding so that the role of parental peer (dis)approval in the link between dating violence experiences and internalizing problems can be further tested.
Patient-Reported Outcomes Measurement Information System Test Is Less Responsive Than Legacy Hip-Specific Patient-Reported Outcome Measures in Patients Undergoing Arthroscopy for Femoroacetabular Impingement Syndrome

Purpose To evaluate and compare the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) computerized adaptive test and PROMIS Pain Interference (PI) instruments versus legacy patient-reported outcome measures (PROMs) in patients undergoing hip arthroscopy for femoroacetabular impingement syndrome at 1-year follow-up. Methods Patients undergoing primary hip arthroscopy for the treatment of femoroacetabular impingement syndrome without concomitant procedures performed by a single surgeon between August 2018 and January 2019 were identified. The PROMIS PF score, PROMIS PI score, Hip Outcome Score–Activities of Daily Living Subscale (HOS-ADL), Hip Outcome Score–Sports Subscale (HOS-SS), modified Harris Hip Score (mHHS), International Hip Outcome Tool 12 (iHOT-12), and visual analog scale (VAS) pain score were obtained preoperatively and at 6 months and 1 year postoperatively. Bivariate correlation analyses between PROMIS and legacy PROMs were performed. The floor and ceiling effects, responsiveness, and relative efficiency (RE) of each PROM were calculated. Results This study included 124 patients with an average age of 32.7 ± 12.3 years. The PROMIS PF score showed very good correlations with the HOS-ADL (r = 0.73, P Conclusions At 1-year follow-up, PROMIS PROMs displayed very good correlations with legacy PROMs. However, PROMIS PROMs had lower effect sizes and were not as responsive as legacy PROMs. Level of Evidence Level II, development of diagnostic criteria on the basis of consecutive patients.
Study of the Three-Dimensional Map about Rural Complicated Scene

At present, construction of a rural scene must rely on professional and technical personnel and professional three-dimensional mapping software. Therefore, it needs a great deal time, energy and devotion to construct a complicated scene. This paper builds a rural scene component library with rural new properties, and gets real-time external terrain data with rural mapping assistant equipment. It can build a rural three-dimensional scene graph quickly through an interactive way and using an organization technique of resource list-style. According to experimental results, comparing to the traditional modeling software, this method in this paper is out standing for its simple functions, friendly interaction, short development cycle and favorable commonality.
Channeling radiation and coherent bremsstrahlung for simple lattices : a three-dimensional approach

The effect of the longitudinal variation of the lattice potential is investigated numerically for the case of electron channeling in the low-energy regime. Corrections to the energy of the emitted photons are found to be three dimensional (3D), rather than longitudinal, in character. These 3D effects are small and of about the same size as the error due to shortcomings in the description of the lattice potential. Coherent bremsstrahlung involves transitions between quantum states that emanate from the 3D nature of the potential. The corresponding photon energies and intensities are calculated and compared to available experimental results.
A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes.

Abstract The fgr proto-oncogene encodes a nonreceptor protein-tyrosine kinase, designated p55c-fgr. In this study, we have isolated human fgr cDNA molecules from normal monocyte mRNA templates. Nucleotide sequence analysis of the longest fgr cDNA revealed a 5' untranslated region of 927 bp which included two Alu-like repeats as well as three translation stop codons immediately upstream of the initiator for p55c-fgr synthesis. Within genomic DNA, these sequences were distributed over 13 kbp as three distinct 5' untranslated exons. Previous studies have shown that Epstein-Barr virus (EBV) increases c-fgr mRNA levels in B lymphocytes. By comparing the nucleotide sequence reported for transcripts isolated from EBV-infected B lymphocytes with those of our monocyte cDNA as well as genomic DNA, we identified a novel untranslated exon utilized only in EBV-infected cells. The transcriptional initiation sites of fgr mRNA expressed in EBV-converted cells were mapped and shown to reside within a region identified as an intron for fgr mRNA that is expressed in normal myelomonocytic cells. Furthermore, the region of the fgr locus upstream of the novel exon displayed properties of a transcriptional promoter when transfected into heterologous cells. We conclude from all of these findings that activation of the fgr gene by EBV is achieved by mechanisms distinct from those normally regulating its programmed expression in myelomonocytic cells.
RESPONSE TENDENCIES, ETHNICITY, AND DEPRESSION SCORES

The Center for Epidemiologic Studies Depression scale was given to a sample of whites, blacks, and Mexican-Americans residing in Alameda County, California, in 1978. Scores on the scale were analyzed to see whether or not a potentially important source of bias called response tendencies affected prevalence estimates and associations between symptom scores and demographic variables. Response tendencies were found to be differentially correlated with symptom scores by ethnic status; however, their effects were not of sufficient magnitude to alter most associations observed between symptom scores and demographic variables. The need for further methodological studies to clarify the definitions of concepts such as "depression" is discussed.
A mechanistic model linking insect (Hydropsychidae) silk nets to incipient sediment motion in gravel‐bedded streams

Plants and animals affect stream morphodynamics across a range of scales, yet including biological traits of organisms in geomorphic process models remains a fundamental challenge. For example, laboratory experiments have shown that silk nets built by caddisfly larvae (Trichoptera: Hydropsychidae) can increase the shear stress required to initiate bed motion by more than a factor of 2. The contributions of specific biological traits are not well understood, however. Here we develop a theoretical model for the effects of insect nets on the threshold of sediment motion, τ*crit, that accounts for the mechanical properties, geometry, and vertical distribution of insect silk, as well as interactions between insect species. To parameterize the model, we measure the tensile strength, diameter, and number of silk threads in nets built by two common species of caddisfly, Arctopsyche californica and Ceratopsyche oslari. We compare model predictions with new measurements of τ*crit in experiments where we varied grain size and caddisfly species composition. The model is consistent with experimental results for single species, which show that the increase in τ*crit above the abiotic control peaks at 40–70% for 10–22 mm sediments and declines with increasing grain size. For the polyculture experiments, however, the model underpredicts the measured increase in τ*crit when two caddisfly species are present in sediments of larger grain sizes. Overall, the model helps explain why the presence of caddisfly silk can substantially increase the forces needed to initiate sediment motion in gravel-bedded streams and also illustrates the challenge of parameterizing the behavior of multiple interacting species in a physical model.
Effect of Liver Transplant on Long-term Disease-Free Survival in Children With Hepatoblastoma and Hepatocellular Cancer.

Introduction Hepatoblastoma (HBL) and hepatocellular cancer (HCC) are the most common primary hepatic malignant neoplasms in childhood. Given the rarity of these childhood tumors and their propensity to present at advanced stages, updated long-term data are needed. Objective To determine the efficacy of liver transplant in children with HBL or HCC. Design, Participants, and Setting This single-institution retrospective medical record review and analysis spanned from January 1, 1997, through September 17, 2014, at Stanford University School of Medicine. A total of 40 patients younger than 18 years underwent liver transplant for treatment of HBL (n = 30) or HCC (n = 10) during the study period, with follow-up until September 17, 2014. Patients who underwent transplant for HCC included those with tumors that were greater in size than what is proposed by the Milan (a single tumor measuring ≤5 cm or ≤3 nodules measuring ≤3 cm) and University of California, San Francisco (single tumor measuring ≤6.5 cm or ≤3 nodules measuring ≤4.5 cm and a total diameter of ≤8 cm), criteria. Main Outcomes and Measures Disease-free and overall patient survival and graft survival. Results Using a Kaplan-Meier survival analysis, 1-, 5-, and 10-year disease-free survival after liver transplant was 93%, 82%, and 82%, respectively, for 30 patients with HBL and 90%, 78%, and 78%, respectively, for 10 patients with HCC. Risk factors associated with HBL recurrence after transplant included having pretreatment extent of disease stage IV lesions and a longer waiting list time and being older at the time of the transplant. Recurrence was found in 2 of 7 patients with HBL and pretransplant metastases, which were not found to be an independent risk factor for recurrence. Patients with HCC larger than the proposed Milan and University of California, San Francisco, criteria experienced good 5-year disease-free (82%) and overall (78%) survival after transplant. Being older at the time of transplant (18 vs 11 years; P = .04) and the presence of metastatic disease (1 patient vs none; P = .05) were associated with HCC tumor recurrence. Conclusions and Relevance Liver transplant combined with chemotherapy is an excellent treatment that provides long-term disease-free survival in children diagnosed with advanced HBL and HCC. Early addition to a waiting list and aggressive multimodal therapy provide excellent results. Transplant should still be considered in children with HCC larger than the Milan and University of California, San Francisco, criteria.
Stretched String with Self-Interaction at High Resolution: Spatial Sizes and Saturation

We model the (holographic) QCD Pomeron as a long and stretched (fixed impact parameter) transverse quantum string in flat ${D}_{\ensuremath{\perp}}=3$ dimensions. After discretizing the string in $N$ string bits, we analyze its length, mass and spatial distribution for large $N$ or low $x$ ($x=1/N$), and away from its Hagedorn point. The string bit distribution shows sizable asymmetries in the transverse plane that may translate to azimuthal asymmetries in primordial particle production in the Pomeron kinematics, and the flow moments in minimum bias $pp$ and $pA$ events. At moderately low $x$ and relatively small string self-interactions ${g}_{s}\ensuremath{\approx}{\ensuremath{\alpha}}_{s}$ (the gauge coupling), a presaturation phase is identified whereby the string transverse area undergoes a sharp transition from a large diffusive growth to a small fixed size area set by few string lengths ${l}_{s}$. For lower values of $x$ the transverse string bit density is shown to increase as $1/x$ before saturating at the Bekenstein bound of one bit per Planck area with the Planck length ${l}_{P}/{l}_{s}\ensuremath{\approx}{\ensuremath{\alpha}}_{s}^{2/3}$. We argue that the effects of the ${\mathrm{AdS}}_{5}$ curvature on the interacting string may be estimated using an effective transverse dimension between the interacting string bits. The result is a smoother transition with a transverse string bit density increasing as $1/{x}^{0.31}$.
Interpreting Ancient Figurines: Universalist Explanation and Prehistoric Figurines

“The first god was a goddess!” proclaimed Etienne Renaud in 1929. A dozen tiny figurines from Arizona, perhaps two thousand years old, were the immediate inspiration for Renaud's “bold paradox.” Just inches tall, they were roughly shaped in clay with crude facial features and punctate designs suggesting clothing or ornamentation. All had prominent, modeled breasts. To Renaud, these were “fetishes of the feminine principle of fecundity and reproduction” depicting “a goddess of life.” He supported this contention by embarking on a world tour of ancient female imagery. The itinerary included Western Europe, the Balkans, Southern Russia, Anatolia, Cyprus, Crete, Egypt, and the Near East before he crossed the Atlantic again to finish in Nicaragua and Panama. In case after case, female figurines appeared in the most ancient archaeological strata. Surely, this revealed a deeply rooted “worship of the life-giving mother” and “betray[ed] the same psychology in primitive man of different continents.” Renaud's article succinctly lays out a once-common universalist vision in the study of prehistoric figurines. The goal was to account for the perception that the earliest prehistoric figurines, everywhere, were female. Today, archaeologists are immediately suspicious of Renaud's sweeping cross-cultural generalizations. His drawings, in which a single image stands for each region (Egypt, Crete, Nicaragua), at best seem quaintly amusing. We now insist on serious attention to local variation and context. We also are suspicious of the assumption that the category “female” is stable across contexts. Ambitious cross-cultural explanations are regarded with skepticism.
The effects of selected social and environmental variables on the eating behavior of adults in the natural environment

The current study investigated the effects of social setting, type of restaurant environment, relative weight, and sex on the number of calories consumed by adults. Subjects were observed in 14 different restaurants by trained observers. Results indicated that both males and females consumed more calories in fast-food restaurants and that they ate more when in groups as compared to when they ate alone. Females ate less in larger as compared to smaller groups of people. Relative weight was not associated with the number of calories consumed. Implications of the results are discussed and possible treatment recommendations are outlined.