cssi/SciSciGPT-SciSciNet huggingface dataset:
Modulation of cell proliferation in the embryonic retina of zebrafish (Danio rerio).

We describe light-microscopically the development of the embryonic zebrafish eye with particular attention to cell number, cell proliferation, and cell death. The period from 16 to 36 hr post fertilization (hpf) comprises two phases; during the first (16-27 hpf) the optic vesicle becomes the eye cup, and during the second (27-36 hpf) the eye cup begins to differentiate into the neural retina and pigmented epithelium. All cells in the eye primordium are proliferative prior to 28 hpf, and the length of the cell cycle has been estimated to be 10 hr at 24-28 hpf (Nawrocki, 1985). Our cell counts are consistent with that estimate at that age, but not at earlier ages. A 10-hr cell cycle predicts that the cell number should increase by 7% per hr, but during 16-24 hpf the cell number increased by only 1.5% per hr. Despite the low rate of increase, all cells labeled with bromo-deoxyuridine, so all were proliferative. We considered three possible explanations for the nearly-constant cell number in the first phase: proliferation balanced by cell emigration from the eye, proliferation balanced by cell death, and low proliferation caused by a transient prolongation of the cell cycle. We excluded the first two, and found direct support for the third. Previous examinations of the cell cycle length in vertebrate central nervous system have concluded that it increases monotonically, in contrast to the modulation that we have shown. Modulation of the cell cycle length is well-known in flies, but it is generally effected by a prolonged arrest at one phase, in contrast to the general deceleration that we have shown.
Simulation of the Elastic and Ultimate Tensile Properties of Diamond, Graphene, Carbon Nanotubes, and Amorphous Carbon Using a Revised ReaxFF Parametrization

In light of the enduring interest in using nanostructured carbon materials as reinforcing elements in composite materials, there is a significant need for a reliable computational tool capable to predict the mechanical properties, both elastic properties and properties at the point of fracture, in large-scale atomistic simulations. A revised version of the ReaxFF reactive force field parametrization for carbon, ReaxFFC-2013, was recently published and is notable because of the inclusion of density functional theory (DFT)-derived mechanical data for diamond and graphite in the fitting set. The purpose of the present work is to assess the accuracy of this new force field for predicting the mechanical properties for several allotropes of carbon, both in the elastic regime and during fracture. The initial discussion focuses on the performance of ReaxFFC-2013 for diamond and graphene, the two carbon forms for which mechanical properties were included in the parametrization data set. After it is established that simulations conducted with the new force field yield results that agree well with DFT and experimental data for most properties of interest, its transferability to amorphous carbon and carbon nanotubes is explored. ReaxFFC-2013 is found to produce results that, for the most part, compare favorably with available experimental data for single and multiwalled nanotubes and for amorphous carbon models prepared over a range of densities. Although there is opportunity for improvement in some predicted properties, the ReaxFFC-2013 parametrization is shown to generally perform well for each form of carbon and to compare favorably with DFT and experimental data.
Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart.

Antioxidant properties of thioctic and dihydrolipoic acid have been demonstrated in membranes and low density lipoproteins (LDL) in vitro. In vivo studies with dietary supplementation of thioctic acid to rats showed that it can also protect tissues against oxidative damage. Presumably, this action is due to a thioctic acid dihydrolipoic acid (TA/DHLA) coupled antioxidant mechanism, which enhances the activity of other antioxidants (i.e. ascorbate, α-tocopherol) by regenerating them from their radical form.In the present study, thioctic acid proved to protect against ischemia/reperfusion injury to Langendorff perfused hearts. Hearts isolated from rats fed thioctic acid and subjected to ischemia exhibited better mechanical recovery (left ventricular developed pressure) after reperfusion and lower lactate dehydrogenase leakage. Thioctic acid supplementation also decreased the appearance of fluorescent lipid peroxidation products after ischemia/reperfusion, lowered the rate of 2,2′-azobis-(2,4-dimethylvaleron...
Choice Functions on Tree Quasi-Orders

The domain of social choice functions is extended to tree quasi-orders, and versions of the theorems of Arrow, Muller–Satterthwaite, and Gibbard–Satterthwaite are proved in this setting.
Abstract 446: Rostral Ventrolateral Lateral Medulla Mediates the Sympathetic and Cardiovascular Response to Increased Cerebrospinal Fluid Sodium Concentration

Compelling evidence indicates increased cererbrospinal fluid (CSF) sodium elevates sympathetic nerve activity (SNA) and arterial blood pressure (ABP) in salt-sensitive hypertension. RVLM neurons pr...
The Question of Upper Silesia

It is important to distinguish clearly between an official Upper Silesia, that is, the entire district of Oppeln, and a more narrowly defined Upper-Silesia comprising only the southeastern part of this district most of it being on the right bank of the Oder from Rosenberg to Ratibor, the great industrial region included. After the Hussite Wars (1420-31) Polish law gradually began to prevail among farmers and peasants. It was utilized by magnates after the Thirty Years War (1618-48) in acquiring more and more land, as independent farmers, primarily Germans, lost out; a number of these emigrated to the north and west. The magnates, no more than eight or ten at that time on the right bank of the Oder, were pleased with the Polish laws that favored them and so they employed primarily Polish farmhands, who were completely at the mercy of their masters.
THE EVOLUTION OF COOPERATIVE BREEDING BY DELAYED RECIPROCITY AND QUEUING FOR FAVORABLE SOCIAL POSITIONS.

Cooperative breeding, in which some members of a social group help others to reproduce, recurs as a normal feature of social organization in a variety of birds and mammals. In many cases, these helpers do not themselves reproduce while assisting in the care of others' young. How such apparently altruistic helping could evolve has been a central question in the recent development of sociobiology. The hypotheses advanced so far fit into three general categories (Brown, 1978): (1) immediate, direct benefits for helpers, such as immediate improvement in survival or chances for breeding; (2) indirect benefits as a result of selectively helping genealogical relatives; and (3) delayed, direct benefits as a result of eventually acquiring a favorable position for breeding. This paper focuses on the third category of explanation. The aim is to develop quantitative conditions under which delayed benefits can provide a sufficient explanation for the evolution of helping and to consider some of the evolutionary problems of delayed benefits. It is important to emphasize that the three kinds of hypotheses above are not mutually exclusive. All three effects might contribute to the evolution of cooperative breeding in a particular species or population. Indeed, it is possible that none of the three alone could provide a sufficient explanation for a particular case of cooperative breeding, whereas a combination of two or all three could. Nevertheless, a first step is to test the adequiacy of each hypothesis separately. To make these tests, we need to know the conditions under which each hypothesis can provide a sufficient explanation for the evolution of cooperative breeding. These conditions are comparatively well formulated for the first two hypotheses. For instance, immediate, direct benefits can provide a sufficient explanation for cooperative breeding provided that each individual in a group realizes an immediate gain in fitness, either through production of young or increased survival, in comparison to its fitness when breeding alone. Immediate, direct benefits to group members play an important part in the evolution of cooperative breeding in some species (Vehrencamp, 1978). In many species, however, helpers do not reproduce, or at least have very low chances for reproduction, so that immediate, direct benefits cannot provide a complete explanation for the evolution of helping in these cases. The indirect benefits from kin selection are also relatively well understood. Although these benefits are clearly important in the many species of cooperative breeders in which helpers join their natal groups, kin selection has nevertheless remained a controversial explanation for the evolution of cooperative breeding (Brown, 1978; Brown and Brown, 1981; Emlen, 1978, 1981; Gaston, 1978b; Ligon and Ligon, 1978a, 1978b, 1982; Koenig and Pitelka, 1981; Woolfenden, 1981). To determine whether or not indirect benefits can pro-
Interaction of Saccharomyces cerevisiae HMO2 domains with distorted DNA.

The Saccharomyces cerevisiae high mobility group protein HMO2 is a component of the chromatin remodeling complex INO80. In this capacity, it has been shown to direct INO80 to DNA double-strand breaks, thereby contributing to double-strand break repair. Consistent with such function, HMO2 binds DNA ends, protecting them from exonucleolytic degradation. We show here that both domains of HMO2, HMO2-BoxA and HMO2-BoxB, bind preferentially to distorted DNA, with HMO2-BoxA binding preferentially to four-way DNA junctions and DNA with tandem mismatches and HMO2-BoxB binding four-way junctions as well as DNA with stem–loop structures, tandem mismatches, and abasic sites. As previously reported for mammalian high mobility group proteins, the acidic C-terminal extension significantly attenuates DNA binding. Notably, the unique ability of HMO2 to protect DNA ends is conferred by the Box A domain. Considering the reported roles for INO80 in other events such as recovery of stalled replication forks and nucleotide exc...
Editorial Comment: Oesophageal cancer staging: refining regional lymph node classification (N)

We read with great interest the article by D’Annoville et al. [1], which investigates the association of metastatic oesophageal cancer extension outside the capsule of regional lymph nodes (ECLNI) and ‘disease-free survival’. ECLNI, a site-specific factor in the American Joint Committee on Cancer (AJCC) 7th edition staging manual, should be recorded for all oesophageal cancer patients with regional lymph node metastases (positive nodes) [2]. It is being actively collected by the Worldwide Esophageal Cancer Collaboration (WECC) for inclusion in the analysis that will produce the 8th edition cancer staging recommendations.
Luteotropic and Luteolytic Effects of Rat Chorionic Mammotropin

SummaryThe results of the experiments reported herein support the findings of Malven and Sawyer (11) that a luteotropic hormone, capable of stimulating luteal cell synthesis and secretion of progestogen, can also be luteolytic. Rat chorionic mammotropin, a potent luteotropic hormone detectable during midpregnancy may under some circumstances have an opposite effect on luteal cells and become luteolytic. The dose of 0.1 ml of serum from rats 12 days pregnant promoted hypertrophy in newly formed luteal cells and continuing progestogen secretion if injected commencing on the day of hypophysectomy or 1 day later. This luteotropic potency is equal to about 1.5 IU of ovine pituitary LTH as tested in 1-month-old rats. Both luteotropic hormones induce luteolysis at the same dose level (or higher levels) if the luteal cells are deprived of trophic hormone for 48 hr or more. There has been no evidence favoring a rat placental ICSH (LH) as the luteolytic factor in these experiments but this possibility, under differ...
The genetics of Parkinson’s disease

The recent identification of several genes and gene loci linked to familial forms of Parkinson’s disease (PD) has contributed significantly to our understanding of the genetic contribution in PD. Although the etiology of sporadic PD remains unknown, it is currently assumed that genetic susceptibilities may be involved. The advent of genome-wide scanning techniques has now made it possible to conduct complete genome screens for linkage in PD in multigenerational parkinsonian kindreds. Such studies undoubtedly will be instrumental in establishing the susceptibility genes involved in idiopathic PD. This article reviews the recent advances in the genetics of PD.
Analysis and Application on Public Opinion of Network Monitoring System in Power Enterprise

With the rapid development of network information,the internet is rapidly expanding as an ideological position,making more and more people are willing to express their personal thoughts through a network as channels.This article describes the network of public opinion monitoring system architecture,information collection methods and various functions to enhance the monitoring and analysis of internet information,the network for power companies to respond quickly to emergencies and complete control of society and public opinion has a positive effect.
A Case of Recurrent Insomnia: Extending the Spectrum of Autoimmune Encephalitis.

Recurrent insomnia is an uncommon manifestation that is encountered rarely in a sleep clinic. We report a woman with recurrent insomnia due to an autoimmune process that resolved after a course of ...
Verified lifting of stencil computations

This paper demonstrates a novel combination of program synthesis and verification to lift stencil computations from low-level Fortran code to a high-level summary expressed using a predicate language. The technique is sound and mostly automated, and leverages counter-example guided inductive synthesis (CEGIS) to find provably correct translations. Lifting existing code to a high-performance description language has a number of benefits, including maintainability and performance portability. For example, our experiments show that the lifted summaries can enable domain specific compilers to do a better job of parallelization as compared to an off-the-shelf compiler working on the original code, and can even support fully automatic migration to hardware accelerators such as GPUs. We have implemented verified lifting in a system called STNG and have evaluated it using microbenchmarks, mini-apps, and real-world applications. We demonstrate the benefits of verified lifting by first automatically summarizing Fortran source code into a high-level predicate language, and subsequently translating the lifted summaries into Halide, with the translated code achieving median performance speedups of 4.1X and up to 24X for non-trivial stencils as compared to the original implementation.
Applications of underwater fields

Though severely limited in range by the attenuation of seawater, underwater electric, magnetic and electromagnetic fields are being utilized in a wide variety of oceanographic applications. Many present uses of underwater fields are essentially straightforward extensions of land-based applications. Other uses, however, involve techniques that may be applied only in the underwater environment. This paper will survey the various applications which make use of electrostatic and magnetostatic fields as well as the low audio frequency electromagnetic channel.
Thiolate-based dinitrosyl iron complexes: Decomposition and detection and differentiation from S-nitrosothiols

Dinitrosyl iron complexes (DNIC) spontaneously form in aqueous solutions of Fe(II), nitric oxide (NO), and various anions. They exist as an equilibrium between diamagnetic, dimeric (bi-DNIC) and paramagnetic, monomeric (mono-DNIC) forms. Thiolate groups (e.g., on glutathione or protein cysteine residues) are the most biologically relevant anions to coordinate to Fe(II). Low molecular weight DNIC have previously been suggested to be important mediators of NO biology in cells, and emerging literature supports their role in the control of iron-dependent cellular processes. Recently, it was shown that DNIC may be one of the most abundant NO-derived products in cells and may serve as intermediates in the cellular formation of S-nitrosothiols. In this work, we examined the stability of low molecular weight DNIC and investigated issues with their detection in the presence of other NO-dependent metabolites such as S-nitrosothiols. By using spectrophotometric, Electron Paramagnetic Resonance, ozone-based chemiluminesence, and HPLC techniques we established that at neutral pH, bi-DNIC remain stable for hours, whereas excess thiol results in decomposition to form nitrite. NO was also detected during the decomposition, but no S-nitrosothiol formation was observed. Importantly, mercury chloride accelerated the degradation of DNIC; thus, the implications of this finding for the diagnostic use of mercury chloride in the detection of S-nitrosothiols were determined in simple and complex biological systems. We conclude S-nitrosothiol levels may have been substantially overestimated in all methods where mercury chloride has been used.
Evaluation of user-guided semi-automatic decomposition tool for hexahedral mesh generation

Abstract Volumetric decomposition is essential for all-hexahedral mesh generation. Because fully automatic decomposition methods that can generate high-quality hexahedral meshes for arbitrary volumes have yet to be realized, manual decomposition is still required frequently. Manual decomposition is a laborious process and requires a high level of user expertise. Therefore, a user-guided semi-automatic tool to reduce the human effort and lower the requirement of expertise is necessary. To date, only a few of these approaches have been proposed, and a lack of user evaluation makes it difficult to improve upon this approach. Based on our previous work, we present a user evaluation of a user-guided semi-automatic tool that provides visual guidance to assist users in determining decomposition solutions, accepts sketch-based inputs to create decomposition surfaces, and simplifies the decomposition commands. This user evaluation investigated (1) the usability of the visual guidance, (2) the types of visual guidance essential for decomposition, (3) the effectiveness of the sketch-based decomposition, and (4) the performance differences between beginner and experienced users using the sketch-based decomposition. The result and user feedback indicate that the tool enables users who have limited prior experience or familiarity with the computer-aided engineering software to perform volumetric decomposition more efficiently. The visual guidance increases the success rate of the user’s decomposition solution by 28%. The sketch-based decomposition significantly reduces 46% of the user’s time on creating decomposition surfaces and setting up decomposition commands.
Painting the Soul: A Complex Legacy of Romanticism in Edith Johnstone’s New Woman Novel, A Sunless Heart (1894)

In the last decade of the twentieth century, the scholarly consensus was that genius was incompatible with what Lyn Pykett terms the “proper feminine.” This incompatibility makes the “New Woman” ar...
Neighborhood characteristics and resistance to the impacts of housing abandonment

Housing abandonment is often disproportionally distributed across a city. Past research has determined that a number of neighborhood socioeconomic and spatial characteristics are associated with ho...
Residual Efficacy of Chlorpyrifos and Diazinon Formulations for German Cockroaches (Orthoptera: Blattellidae) on Panels Placed in Commercial Food Preparation Areas

Ceramic and stainless steel panels were treated with chlorpyrifos (Dursban LO or ME) or diazinon (Knox Out 2FM) and aged in a commercial kitchen. Type of surface (ceramic tile or stainless steel) d...
Gate-all-around FET based 6T SRAM design using a device-circuit co-optimization framework

Gate-all-around nanowire transistor is deemed as one of the most promising solutions that enables continued CMOS scaling. Compared with FinFET, it further suppresses short-channel effects by providing superior electrostatic control over the channel. Due to the unique device structure, gate-all-around nanowire transistor also allows more efficient layout design by exploiting 3-dimensional stacking configurations. In this paper, we investigate the 6T SRAM cell design for gate-all-around nanowire transistors using a device-circuit co-optimization framework. At the device level, TCAD simulation and current source modeling method are applied to extract the model. Layout designs with horizontal, lateral, vertical stacking device structures are explored. At the circuit level, read and write assist techniques are studied to relieve the negative impact of low on-currents on SRAM stabilities incurred by nanowire channels. Operating at 300 mV, assist techniques can increase the read static noise margin and the write static noise margin of 6T SRAM up to 82% and 92%, respectively.
Professional nursing values: A concept analysis

Aim The aim of this concept analysis is to clarify the meaning of professional nursing values. Background In a time of increasing ethical dilemmas, it is essential that nurses internalize professional values to develop and maintain a professional identity. However, nursing organizations and researchers provide different conceptions of professional nursing values, leading to a lack of clarity as to the meaning and attributes of this construct. Design Walker and Avant's (2011) method was used to guide an analysis of this concept. Data Source Resources published from 1973 to 2016 were identified via electronic databases and hand-searching of reference lists. Review Methods A review of the literature was completed and the data were analyzed to identify uses of the concept; the defining attributes of the concept; borderline, related, contrary, and illegitimate examples; antecedents and consequences; and empirical referents. Results Professional nursing values were defined as important professional nursing principles of human dignity, integrity, altruism, and justice that serve as a framework for standards, professional practice, and evaluation. Conclusions Further research is needed in the development and testing of professional nursing values theory, and the reassessment of values instruments. Core professional values that are articulated may help unify the profession and demonstrate the value of nursing to the public.
Concluding Reflections: From Research to Policy and Practice

In a set of final reflections, the distinctive strengths of the Capabilities Approach are taken into account and selected areas for future research, policy and practice are identified.
Social Work with Transsexuals

The social worker can be of significant help in the treatment of the transsexual client through informed use of skills and creation of a network of resources
The effect of electronic medical record system sophistication on preventive healthcare for women

Objective To observe the effect of electronic medical record (EMR) system sophistication on preventive women's healthcare. Materials and Methods Providers in the National Ambulatory Medical Care Survey (NAMCS), 2007–8, were included if they had at least one visit by a woman at least 21 years old. Based on 16 questions from NAMCS, the level of a provider's EMR system sophistication was classified as non-existent, minimal, basic, or fully functional. A two-stage residual-inclusion method was used with ordered probit regression to model the level of EMR system sophistication, and outcome-specific Poisson regressions to predict the number of examinations or tests ordered or performed. Results Across the providers, 29.23%, 49.34%, 15.97%, and 5.46% had no, minimal, basic, and fully functional EMR systems, respectively. The breast examination rate was 20.27%, 34.96%, 37.21%, and 44.98% for providers without or with minimal, basic, and fully functional EMR systems, respectively. For breast examinations, pelvic examinations, Pap tests, chlamydia tests, cholesterol tests, mammograms, and bone mineral density (BMD) tests, an EMR system increased the number of these tests and examinations. Furthermore, the level of sophistication increased the number of breast examinations and Pap, chlamydia, cholesterol, and BMD tests. Discussion The use of advanced EMR systems in obstetrics and gynecology was limited. Given the positive results of this study, specialists in women's health should consider investing in more sophisticated systems. Conclusions The presence of an EMR system has a positive impact on preventive women's healthcare; the more functions that the system has, the greater the number of examinations and tests given or prescribed.
Performance Analysis of Live-Virtual-Constructive and Distributed Virtual Simulations: Defining Requirements in Terms of Temporal Consistency

This research extends the knowledge of live-virtual-constructive (LVC) and distributed virtual simulations (DVS) through a detailed analysis and characterization of their underlying computing architecture. LVCs are characterized as a set of asynchronous simulation applications each serving as both producers and consumers of shared state data. In terms of data aging characteristics, LVCs are found to be first-order linear systems. System performance is quantified via two opposing factors; the consistency of the distributed state space, and the response time or interaction quality of the autonomous simulation applications. A framework is developed that defines temporal data consistency requirements such that the objectives of the simulation are satisfied. Additionally, to develop simulations that reliably execute in real-time and accurately model hierarchical systems, two real-time design patterns are developed: a tailored version of the model-view-controller architecture pattern along with a companion Component pattern. Together they provide a basis for hierarchical simulation models, graphical displays, and network I/O in a real-time environment. For both LVCs and DVSs the relationship between consistency and interactivity is established by mapping threads created by a simulation application to factors that control both interactivity and shared state consistency throughout a distributed environment.
Pb2Y0.5Ca0.5Sr2Cu3O8+x Superconducting Ceramics from Glass Crystallization

Pb2Y0.5Ca0.5Sr2Cu3Oy forms a glass. The glass transition temperature and the first crystallization temperature of the glass are 344°C and 387°C, respectively. The density of the glass is 6.3146 g/cm3. Heat treatments of the glass in air do not produce Pb2Y0.5Ca0.5Sr2Cu3Oy superconducting phase at all temperatures, but heat treatments of the glass in argon yield the Pb2Y0.5Ca0.5Sr2Cu3Oy phase starting at 430° C. After being heat treated at 660°C for 8 hours in argon, the sample is superconducting with an onset Tc of 80 K.
The interplay between neutrophils and microbiota in cancer

The role of the microbiota in many diseases including cancer has gained increasing attention. Paired with this is our expanding appreciation for the heterogeneity of the neutrophil compartment regarding surface marker expression and functionality. In this review, we will discuss the influence of the microbiota on granulopoiesis and consequent activity of neutrophils in cancer. As evidence for this microbiota-neutrophil-cancer axis builds, it exposes new therapeutic targets to improve a cancer patient's outcome.
Journalism and mass communication capstone course: Bringing it all together?

Although most higher education programs include a capstone course to culminate the student experience, program directors disagree on what the experience should look like. Updating previous research...
Simultaneous acute appendicitis in identical twin boys

Acute appendicitis is one of the most common causes of abdominal pain in children but remains a diagnostic challenge, and insight into the aetiology of the condition is lacking. A case of simultaneous acute appendicitis in monozygotic twin boys is reported here. Familial aggregation in acute appendicitis has been described, but the underlying causes for this are not well understood. The patients reported here were both genetically identical and lived a mostly identical lifestyle. Their simultaneous presentation would be exceedingly rare if explained entirely by chance, suggesting a role for both genetic and environmental influences. Increased knowledge of this occurrence may assist in prompt diagnosis and reporting on the incidence and timing of appendicitis in monozygotic twins could better elucidate the genetic and environmental factors that predispose to this disease.
Dissemination and implementation science activities across the Clinical Translational Science Award (CTSA) Consortium: Report from a survey of CTSA leaders.

Introduction: Dissemination and implementation (D&I) science is not a formal element of the Clinical Translational Science Award (CTSA) Program, and D&I science activities across the CTSA Consortium are largely unknown. Methods: The CTSA Dissemination, Implementation, and Knowledge Translation Working Group surveyed CTSA leaders to explore D&I science-related activities, barriers, and needed supports, then conducted univariate and qualitative analyses of the data. Results: Out of 67 CTSA leaders, 55.2% responded. CTSAs reported directly funding D&I programs (54.1%), training (51.4%), and projects (59.5%). Indirect support (e.g., promoted by CTSA without direct funding) for D&I activities was higher – programs (70.3%), training (64.9%), and projects (54.1%). Top barriers included funding (39.4%), limited D&I science faculty (30.3%), and lack of D&I science understanding (27.3%). Respondents (63.4%) noted the importance of D&I training and recommended coordination of D&I activities across CTSAs hubs (33.3%). Conclusion:These findings should guide CTSA leadership in efforts to raise awareness and advance the role of D&I science in improving population health.
Forgotten @ Scale: A Practical Solution for Implementing the Right To Be Forgotten in Large-Scale Systems

The European General Data Protection Regulation asserts data subjects' right to be forgotten, i.e., their right to request that all their personal data be deleted from an organizations' data stores. However, fulfilling such requests in large-scale systems is technically challenging. It requires that organizations keep track of all locations in which an individual's data is stored, be able to access and delete it in a reasonable time frame, and be able to prove that all such data was in fact deleted. In addition, organizations must cope with complexities such as multiple, distributed, and continuously evolving systems of record, complex data retention policies and deletion approval workflows. We present a first design pattern and practical implementation of the right to be forgotten on a large scale in Big Data and cloud environments.
Advances in surgical hemostasis: a comprehensive review and meta-analysis on topical tranexamic acid in spinal deformity surgery

Tranexamic acid (TXA) is an effective and commonly used hemostatic agent for perioperative blood loss in various surgical specialties. It is being increasingly used in spinal deformity surgery. We aimed to evaluate the safety and efficacy of topical TXA (tTXA) compared to both placebo and/or intravenous (IV) TXA in patients undergoing spinal deformity surgery. We conducted a systematic review of the electronic databases using different MeSH terms from January 1970 to August 2019. Pooled and subgroup analysis was performed using fixed and random-effect model based upon the heterogeneity (I2). A total of 609 patients (tTXA: n = 258, 42.4%) from 8 studies were included. We found that there was a statistically significant difference in terms of (i) postoperative blood loss [mean difference (MD) − 147.1, 95% CI − 189.5 to − 104.8, p < 0.00001], (ii) postoperative hemoglobin level (MD 1.09, 95% CI 0.45 to 1.72, p = 0.0008), (iii) operative time (MD 7.47, 95% CI 2.94 to 12.00, p < 0.00001), (iv) postoperative transfusion rate [odds ratio (OR) 0.39, 95% CI 0.20 to 0.78, p = 0.007], postoperative drain output (MD, − 184.0, 95% CI − 222.03 to − 146.04, p < 0.00001), and (v) duration of hospital stay (MD − 1.14, 95% CI − 1.44 to − 0.85, p < 0.00001) in patients treated with tTXA compared to the control group. However, there was no significant difference in terms of intraoperative blood loss (p = 0.13) and complications (p = 0.23) between the two comparative groups. Furthermore, low-dose (250–500 mg) tTXA (p < 0.00001) reduced postoperative blood loss more effectively compared to high-dose tTXA (1–3 g) (p = 0.001). Our meta-analysis corroborates the effectiveness and safety of tTXA in spinal deformity surgery.
Transfer learning improves antibiotic resistance class prediction

Motivation: Antibiotic resistance is a growing public health problem, which affects millions of people worldwide, and if left unchecked is expected to upend many aspects of healthcare as it is practiced today. Identifying the type of antibiotic resistant genes in genome and metagenomic sample is of utmost importance in the prevention, diagnosis, and treatment of infections. Today there are multiple tools available that predict antibiotic resistance class from DNA and protein sequences, yet there is a lack of benchmarks on the performances of these tools. Results: We have developed a dataset that is curated from 15 available databases, and annotated with their antibiotic class labels. We also developed a transfer learning approach with neural networks, TRAC, that outperforms existing antiobiotic resistance prediction tools. While TRAC provides the current state-of-the-art performance, we hope our newly developed dataset will also provide the community with a much needed standardized dataset to develop novel methods that can predict antibiotic resistance class with superior prediction performance. Availability: TRAC is available on github https://github.com/nafizh/TRAC and the datasets are available at figshare https://doi.org/10.6084/m9.figshare.11413302.
Two-photon laser-induced fluorescence of sodium in multiphase combustion

Alkali metals are prevalent in coal combustion, biomass thermal conversion to fuels, and energetic material combustion, and have applications as dopants for combustion diagnostics and plasma-based combustion control. Recently, the dynamic control of propellant burning rate and pyrotechnic luminosity have been demonstrated through combined microwave field radiation and incorporation of alkali dopants. Understanding of the alkali distribution within the flame is essential to predicting field–flame interaction. However, the multiphase propellant combustion environment exhibits significant particle scattering, broadband emission background, and high optical density, which complicate optical measurements. Here, multiple two-photon laser-induced fluorescence (LIF) schemes for atomic sodium were compared in gas-phase flames and sodium-doped solid propellant combustion. For the two-photon Na LIF scheme, a rate equation model incorporating fluorescence, amplified spontaneous emission, and ionization shows good agreement with experimental characterization in a gas-phase flame. The technique was then extended to sodium-doped solid propellant flames, a multiphase combustion environment characterized by strong particle scattering. The 3s–3d two-photon excitation LIF achieved a better signal-to-noise ratio of ∼100 in the propellant flame and allowed imaging of gradients in the gas-phase sodium distribution at the burning surface.
Patients with high-grade alectinib-induced skin rash: How do we desensitize these patients? A case report and review of literature

With the advent of targeted therapy for non-small-cell lung cancer, there are many new available treatment options for patients whose cancer harbors an actionable mutation or alteration. These new ...
Correction to: Denominational and Gender Differences in Hypertension Among African American Christian Young Adults.

Readers should note that the “95% CI” column of estimates for Model 1 was erroneously included under the Model 2 heading in Table 2 in this article as originally published.
Taming the News Feed on Facebook: Understanding Consumptive News Feed Curation through a Social Cognitive Perspective

As algorithms are increasingly integrated into news selection and consumption processes, it is crucial to understand how news users respond to them. Drawing upon social cognitive theory, this study...
Examination of structural brain changes in recent suicidal behavior.

Abstract We aimed to identify brain structural changes in cortical and subcortical regions linked to recent suicidal behavior. We performed secondary analyses of structural MRI data of two independent studies, namely the Establishing Moderators/Biosignatures of Antidepressant Response - Clinical Care (EMBARC) study and a Little Rock study on acute suicidal behavior. Study 1 (EMBARC, N = 187), compared individuals with remote suicide attempts (Remote-SA), individuals with lifetime suicide ideation but no attempts (Lifetime-SI only), and depressed individuals without lifetime suicide ideation or attempts (non-suicidal depressed). Study 2 (Little Rock data, N = 34) included patients recently hospitalized for suicide ideation or attempt constituted by: patients who recently attempted suicide (Recent-SA), individuals with remote suicide attempts (Remote-SA), and Lifetime-SI only. Study 3 combined the EMBARC and Little Rock datasets including Recent-SA, Remote-SA, Lifetime-SI only and non-suicidal depressed individuals. In Study 1 and Study 2, no significant differences were observed between groups. In Study 3, significantly lower middle temporal gyrus thickness, insular surface area, and thalamic volume and higher volume in the nucleus accumbens were observed in Recent-SA. This pattern of structural abnormalities may underlie pain and emotion dysregulation, which have been linked to the transition from suicidal thoughts to action.
The Santa Clara Strength of Religious Faith Questionnaire (SCSRFQ): A Brief, Nondenominational, and Multicultural Assessment Tool

The Santa Clara Strength of Religious Faith Questionnaire (SCSRFQ) was developed and published in 1997 as a very brief and general purpose self-report instrument that provides an overall index of strength of religious faith. It was developed to be used with most all faith traditions and over the decade numerous studies from across the globe have been conducted in multiple languages and cultures as well as within multiple faith traditions. Overall, published and peer reviewed research has found the scale to be reliable, valid, and useful in multiple settings applied to diverse research, clinical, medical, and educational environments as well. Since the scale is brief, completely free to use, and general enough for diverse faith and spiritual traditions and cultures it can be integrated into many different research projects with diverse populations as well as can be used clinically in medical, psychiatric, and educational environments. This chapter introduces the scale, discusses the theoretical underpinnings of the instrument and the individual items utilized in its development, highlights much of the research that has investigated the psychometric properties of the instrument, and summarizes many of the major results from numerous research studies that have used the SCSRFQ during the past several decades. The chapter also discusses some of the more relevant literature regarding assessment approaches to religious and spiritual engagement as well as a general critique of the SCSRFQ approach. The scale published in multiple languages is also includes in the chapter as well.
Frequency of persistent obesity 5 years after first time diagnosis of status asthmaticus.

BACKGROUND/OBJECTIVES When a severe asthma exacerbation occurs in an obese pediatric patient, it is unknown if this body type persists in future encounters. Persistent obesity can lead to future asthma exacerbations. The main study objective is to evaluate the persistence of a BMI percentile ≥85th in children 5 years after the first reported diagnosis of status asthmaticus. We hypothesized that a hospital admission for status asthmaticus was associated with persistence of a BMI percentile ≥85th. METHODS This was a long-term retrospective observational cohort study utilizing TriNetX ® electronic health record (EHR) data. We included subjects aged 2 to 18 years of age with a diagnosis of status asthmaticus. Study population was divided into two groups based on their admission body mass index percentile: (underweight/healthy weight [<85th percentile] and overweight/obese [≥85th percentile]) and evaluated for the following outcomes: age, race, ethnicity, diagnostic codes, and BMI percentiles (initially and 5 years after diagnosis of status asthmaticus). RESULTS A total of 129 subjects (n%) (76 [58.9%] underweight/healthy weight and 53 [41.1%] overweight/obese) were included. Children that were initially overweight/obese with status asthmaticus had significantly increased odds of continuing to be overweight/obese 5 years after diagnosis compared to children who were underweight/healthy weight at baseline (OR = 7.50 [95% confidence interval, 3.20-17.60; p < 0.001]). CONCLUSIONS Overweight/obese asthmatic children are at risk of continuing to be obese several years after being diagnosed with status asthmaticus. This study reinforces the notion that when an asthmatic obese child presents with status asthmaticus, a thorough evaluation of nutrition, physical activity, and asthma control should be considered to reduce the risk of persistent obesity and possibly future asthma exacerbations.
Preventive HIV-1 Vaccines

The World Health Organization (WHO) has estimated that 40 million individuals are living with HIV-1 as of 2003 (UNAIDS/WHO, 2003). In addition, approximately 14,000 people are newly infected with HIV-1 each day, worldwide (UNAIDS/WHO, 2003). Thus, there is tremendous public health interest in developing safe and effective preventive HIV-1 vaccines. Vaccines have proven to be one of the most effective means of preventing serious infectious diseases. The contribution of vaccines toward markedly decreasing the incidence of many of the once-common childhood infectious diseases has been particularly notable (CDC, 1999). Thus, the public health goal is to develop an effective HIV-1 vaccine that will achieve a similar success in controlling the AIDS epidemic. However, the development of an HIV-1 vaccine has a unique and complex set of scientific, clinical, social, ethical, and economic challenges (Amara and Robinson, 2002; Esparza and Osmanov, 2003; Fast et al., 1995; Goldenthal et al.,1998; Klausner et al., 2003; Nathanson and Mathieson, 2000). Collaborative efforts in the development of an effective HIV-1 vaccine are ongoing among government agencies, academic investigators, and pharmaceutical and biotechnology companies. Even more organization on a global scale has been strongly encouraged (Klausner et al., 2003).
Medusa's Severed Head

Gazes from a Grecian urn strangely peaceful, Demure. Serpents tranquil. Floating down the gallery hall, motes of Opera keep expanding my body's Cubic volume and who wouldn't rather be her? Sleek black hair, black velvet bow: the Japanese soprano. Sometimes I think Joe's daughter Woke up angry the morning She was born. Fourteen years old, beauty that Switchblade she can't stop rubbing Absently with one thumb. I married them. Certain days her silence Shimmers our house Till roof-tiles twitch and burn.
A Novel Approach to Robotic Cardiac Surgery Using Haptics and Vision

Cardiovascular disease is one of the leading causes of death in the United States and also a major disease nationwide. Over 700,000 coronary artery bypass graft (CABG) procedures are performed annually all around the world, of which 350,000 are performed in the United States. The use of mechanical stabilizers to isolate and immobilize the surface region of the heart is not without its limitations such as hemodynamic deterioration, and arrythmia induction requiring inotropic support. Consequently, the use of mechanical stabilizers leads to a poor immobilization of the surgical field in spite of significant forces of traction and retraction used with these devices. The primary goal of this research is to develop effective haptic (sense of touch) and visual servoing methods with the long-term goal of eliminating the need for mechanical stabilizers and extracorporeal support for CABG procedures. We present in this paper the results from our initial work in the area of tracking a deformable membrane using vision and providing haptic feedback to the user, based on the visual information through the vision hardware and the material properties of the membrane. In our first experiment, we track the deformation of a rubber membrane in real-time through stereovision while providing haptic feedback to the user interacting with the reconstructed membrane through the PHANToM haptic device. In the second experiment, we verify the ability of our vision system to track a point on a surface undergoing a complex 3D motion.
A novel cilia-based feature within the food grooves of the ctenophore Mnemiopsis mccradyi Mayer

We describe a novel compound ciliary structure (g-cilium) from the food groove of the lobate ctenophore Mnemiopsis mccradyi. G-cilia are small, flat compound ciliary organelles that are oriented with their tips pointing toward the mouth. Typically three to four rows of g-cilia line the inner surface of the tentacular groove, which together with the transport groove, make up the food groove. G-cilium cells are ~11.4 μm long and ~4.2 μm wide at the g-cilium base. The g-cilium itself is ~3.4 μm long and tapers to a flat, sharp tip. G-cilia are not motile but are surrounded by many hundreds of smaller, actively motile cilia that beat with orally-directed effective strokes. G-cilia contain ~50 conventional ‘9+2’ cilia embedded in a fibrous core that arises from the cell body. In addition, g-cilia contain mitochondria, thousands of small membrane-bounded vesicles and rod bacteria. G-cilia basal bodiesare anchored by large, strongly-banded rootlets that extend approximately the entire length of the cell. G-cilia may have organizational, sensory and/or secretory function within the feeding apparatus. Their placement strongly suggests that they play critical roles in feeding. They may enhance the efficiency of prey capture and so contribute to M. mccradyi’s well-known voracious appetite. By enhancing prey capture they probably playa critical role in the capacity of this organism to follow prey dynamics, so contributing to dense blooms in mid-late summer in coastal regions.