cssi/SciSciGPT-SciSciNet huggingface dataset:
A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene.

A new long form of the c-Maf transcription factor (Lc-Maf) was identified and shown to interact specifically with SOX9 in a yeast two-hybrid cDNA library screening. Lc-Maf encodes an extra 10 amino acids at the carboxyl terminus of c-Maf and contains a different 3′-untranslated region compared with c-Maf. The interaction between SOX9 and Lc-Maf was further confirmed by co-immunoprecipitation and glutathione S-transferase pull-down assays, which mapped the interacting domain of SOX9 to the high mobility group box DNA binding domain and that of Lc-Maf to the basic leucine zipper motif. In situ hybridizations showed that Lc-Maf RNA was coexpressed withSox9 and Col2a1 RNA in areas of precartilaginous mesenchymal condensations during mouse embryo development. A DNA binding site of Lc-Maf was identified at the 5′-end of a 48-bp Col2a1 enhancer element near the high mobility group binding site of SOX9. Lc-Maf and SOX9 synergistically activated a luciferase reporter plasmid containing a Col2a1 enhancer and increased the transcription of the endogenous Col2a1gene. In summary, Lc-Maf is the first transcription factor shown to interact with Sox9, to be coexpressed with Sox9 during an early step of chondrogenesis and to cooperate with Sox9 in activating a downstream target gene of Sox9.
Analysis and Modeling of Damage in RRP Nb 3 Sn Wires During Cabling

High-critical current density (J c ) Nb 3 Sn wires such as restacked-rod process wires are used in Rutherford cables for high-field superconducting magnets. However, during cabling, the wires experience strong plastic strains, which break some superconducting sub-elements and can degrade the electromagnetic performances. The damage can be reduced by forming Cu-Sn phases in the sub-elements during an annealing process prior to cabling. We found experimentally that annealing plays a significant role in reducing damage. Furthermore, we used finite-element models to validate the observations on samples and quantify the impact of annealing on damage reduction.
Fabrication of three-dimensional photonic crystals with multilayer photolithography

We have developed a new approach for the fabrication of three-dimensional photonic crystals based on multi-layer photolithography. This method, which uses commercially available photoresist, allows parallel fabrication of three-dimensional photonic crystals, and possesses the flexibility to create a variety of different lattice arrangements and the freedom of arbitrary defect introduction. We describe in this work how this method is derived from mature two-dimensional photolithography and demonstrate it with the fabrication of multi-layer woodpile structures with and without defects as well as other unique three-dimensional microstructures.
Shape memory polymer actuated hollow snap-fit design analysis

Abstract With the increasing environmental requirements for recycling technologies at the end of product lifecycle, active disassembly is becoming more and more important especially for electric and electronic product recycling. Active disassembly using smart material (ADSM) has been studied in the past decade. However, ADSM have not been widely applied due to the cost, material properties, and limited supply. Shape memory polymer (SMP) actuated hollow snap-fit may become one of the possible alternatives in ADSM, which will reduce the usage of smart materials and increase the mechanical properties of snap-fit. This research is aimed to fully investigate the SMP-actuated hollow snap-fit design and propose some guidelines for its future implementation. The correlation between design parameters and two major design objectives, maximum deflection and mating force, were analyzed using FEA software. Furthermore, an approach to search the optimal design values for given design requirements was presented. In order to maximize the recovery force generated by SMP in active disassembly process, an investigation of magnifying the deformation stress by engineering actuator’s shape design was completed. The methods and conclusion presented in this paper could be used as reference for hollow snap-fit development and application.
Guideline adherence in management of stable chronic obstructive pulmonary disease.

Summary Background Chronic obstructive pulmonary disease (COPD) is the only leading cause of death with rising morbidity and mortality. Clinical practice guidelines (CPGs) to optimize pharmacotherapy for patients with COPD have been updated based on promising results of randomized clinical trials. We examined the frequency of and factors associated with guideline adherence by physicians in clinical practice at an academic medical center. Methods Patients with a clinical diagnosis of COPD, confirmed by spirometry, who presented to the ambulatory clinics, were enrolled. The primary outcome was provider's adherence to the 2007 Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. Subjects were categorized as guideline-concordant who received a rescue inhaler (all patients), or at least one long-acting bronchodilator (stage II), or at least one long-acting bronchodilator plus an inhaled corticosteroid (stage III–IV). Demographics, clinical information and type of provider were recorded. Provider type was classified as primary care physician (PCP), pulmonologist, or co-management by both. Results Among 450 subjects who met study criteria, 246 (54.7%) received guideline-concordant treatment. Age, sex, race, disease severity, and co-morbidities were not associated with guideline adherence. Multivariate analysis showed that patients co-managed by a PCP and pulmonologist had a higher likelihood of receiving guideline-concordant treatment than those managed by one or the other (Odds Ratio: 4.59; 95% Confidence Interval: 2.92, 7.22, p Conclusions Just over half of stable COPD patients receive guideline-concordant care. Co-management by a PCP and pulmonologist increases the likelihood of receiving guideline-concordant inhaler therapy.
The PEA Strategy: One Teacher's Approach to Integrating Writing in the Social Studies Classroom

With the adoption of the Common Core State Standards many social studies teachers are faced with the task of very intentionally integrating writing instruction into their content curriculum. While this task may be daunting, there are research-based instructional frameworks to help teachers implement strategies to support student writing. In this manuscript the Self-Regulated Strategy Development (SRSD), a research-based instructional framework for teaching writing strategies, is described as a helpful framework for designing writing curricula in the social studies classroom. The following manuscript includes a description of one teacher's experience using SRSD to design and implement a strategy (the PEA Strategy) to support argument-based writing in the context of a social studies classroom. The PEA strategy as well as the six stages of SRSD are defined and supported with examples from the teacher's integrated writing curriculum. Suggestions for implementation of SRSD are also provided.
Effect of faulty network components on node availability

Failure of network hardware components in parallel systems results in deterioration of the communication support provided to various nodes. Limited communication capability may result in the unavailability of one or more nodes to users. In this paper, we develop a framework to study the effect of faulty network components on node availability. We use the framework to investigate the specific case of wormhole routed mesh networks under random faults, and evaluate availability for various routing schemes. Results show that availability is poor in current networks, but can be significantly improved by combining simple existing techniques, and a minimal or no change in routing hardware complexity. >
The Dissolution of Metal Corrosion Products in Deionized Water at 38° C (100° F)

The dissolution of the corrosion products of metals in deionized water at 38°C (100°F) is discussed. Copper, tungsten, cadmium, and Mallory-1000 give soluble corrosion products. Mention is made of ...
TWO NEW SPECIES OF ELEUTHERODACTYLUS (ANURA: LEPTODACTYLIDAE) OF THE ALFREDI GROUP FROM EASTERN GUATEMALA

Two new species of frogs of the Eleutherodactylus alfredi group are described from Subtropical and Montane Wet Forests of the Montanas del Mico and the Sierra de Caral of the Caribbean slopes of Guatemala. They differ from other Guatemalan species in the group by having the fifth toe pad wider than the second, few melanophores on the abdominal area of the venter, and dorsal and ventral ground coloration. The species from the Sierra de Caral is larger in overall size and has smaller dentigerous fascicules than the one from the Montanas del Mico. These two species also differ between themselves in dorsal and ventral ground coloration.
The Impact of Training and Development on Employee Job Satisfaction, Loyalty, and Intent to Stay in the Lodging Industry

There is a tremendous amount of literature that explores the relationship between employee job satisfaction and intent to stay. Similarly, recent research in the area of human resources has focused on the impact of human resources practices on various organizational outcomes. In this article the authors explore the relationships between training and development, and employee job satisfaction, loyalty, and intent to stay in four lodging properties in the United States. Results indicate that employees who perceive they have the opportunity to develop new skills are more satisfied with their jobs, more loyal, and more likely to stay with the organization.
Prenatal evaluation for fetal surgery

The selection of fetuses that may benefit with in utero surgery is being developed. Noninvasive and invasive prenatal diagnosis techniques are utilized to try and gain as much knowledge about the fetus so that the appropriate counseling of parents can be undertaken. The most common invasive techniques are amniocentesis and chorionic villus sampling for fetal karyotyping and genetic diagnosis. Noninvasive techniques include ultrasound (2D and 3D), fetal echocardiography and magnetic resonance imaging. Additional techniques such as specific Doppler evaluation of vascular components, new techniques to look at fetal electrocardiograms and the use of computer tomography are also considered. The most common conditions for which in utero fetal surgery is also being considered are twin to twin transfusion syndrome, myelomeningocele, sacrococcygeal teratoma, cystic adenomatoid malformation of the lung with fetal hydrops and other monochorionic twin abnormalities (severe discordant birth defects or twin reversal arterial perfusion sequences). Ongoing evaluation of the sensitivity, specificity, positive and negative predicted values of these evaluation tools is required so that appropriate selection of fetuses for the surgery can be made.
Reducing a Suicidal Person’s Access to Lethal Means of Suicide: A Research Agenda

Reducing the availability of highly lethal and commonly used suicide methods has been associated with declines in suicide rates of as much as 30%–50% in other countries. The theory and evidence underlying means restriction is outlined. Most evidence of its efficacy comes from population-level interventions and natural experiments. In the U.S., where 51% of suicides are completed with firearms and household firearm ownership is common and likely to remain so, reducing a suicidal person’s access to firearms will usually be accomplished not by fiat or other legislative initiative but rather by appealing to individual decision, for example, by counseling at-risk people and their families to temporarily store household firearms away from home or otherwise making household firearms inaccessible to the at-risk person until they have recovered. Providers, gatekeepers, and gun owner groups are important partners in this work. Research is needed in a number of areas: communications research to identify effective messages and messengers for “lethal means counseling,” clinical trials to identify effective interventions, translational research to ensure broad uptake of these interventions across clinical and community settings, and foundational research to better understand method choice and substitution. Approaches to suicide methods other than firearms are discussed. Means restriction is one of the few empirically based strategies to substantially reduce the number of suicide deaths.
Hayek, social justice, and the market: Reply to Johnston

Abstract David Johnston's Rejoinder to my defense of Hayek's critique of social justice, though it has the merit of attempting to deal with Hayek's claim that the very idea of social justice is incoherent (in a way other critics of Hayek have not), fails to undermine that defense. Johnston's suggested counterexample to Hayek's claim that talk of an injustice presupposes an agency responsible for the injustice is not even prima facie plausible; he overlooks crucial disanalogies between the pursuit of social justice and the pursuit of other social goals; and he fails to understand the distinction between Hayek's (negative) case against social justice and his (positive) case for the market.
The curved interfacial crack between dissimilar isotropic solids

Abstract The paper examines analytically the role of curvature on the stress distribution of a curved interfacial crack between dissimilar isotropic solids. The crack-tip fields under in-plane and antiplane shear loading are studied, respectively. Using an asymptotic expansion of the circular interface geometry, the asymptotic solutions of the stress and displacement fields in the vicinity of the curved crack tip derived from modified stress functions is obtained. The eigenfunctions associated with the eigenvalues λ for the curved crack consist of not only rλ terms, but also rλ+1, rλ+2, … terms. In some cases, the terms rλ+1(ln r), rλ+2(ln r), etc. may also exist. Two examples, frictionless contact near the circular crack-tip under in-plane loading and circular interfacial crack subject to antiplane shear loading, are derived in a closed-form asymptotic solution to elucidate the curvature effect. The case of fully open interfacial crack is also briefly described. Comparing the eigenfunction solutions of straight interfaces, the curvature effect enters the stress fields from the third-order term of the asymptotic solution for both cases. The condition for the existence of the r½(lnr) term in the circular interfacial crack with frictionless contact is presented explicitly.
Crystal structure of the radical-cation radical-anion salt from 2,2′-bi-1,3-dithiole and 7,7,8,8-tetracyanoquinodimethane

The three-dimensional structure of the radical-cation radical-anion salt from 2,2′-bi-1,3-dithiole (1) and 7,7,8,8-tetracyanoquinodimethane (2) has been determined by X-ray diffraction methods; the structure is composed of segregated columnar stacks of cations and anions.
Current-Induced Reorientation of Exchange Bias on a Nanoscale

We demonstrate how local heating by an electric current can induce and reorient the exchange bias on a nanoscale. In our experiments we use point contacts ~10 nm in size to inject current densities as high as 10 into F/N/F/AFM exchange-biased spin valves (EBSV) where two ferromagnetic (F) layers are separated by a nonmagnetic (N) metal spacer and one of the Fs is biased by an adjacent antiferromagnetic (AFM) layer. At low currents the spin valves exhibit the usual giant magnetoresistance (GMR) when two F layers switch from parallel to antiparallel orientation. At highest applied currents the Joule heating in the contact becomes significant and in combination with static magnetic field can induce and repeatedly reorient the exchange bias in a small contact volume . The strength of exchange bias induced in the point contact was found to depend on the polarity of the applied current. We tentatively attribute this polarity dependence to spin-transfer torques arising near F/AFM interface at high currents.
QoS-aware optical burst switching in OpenFlow based Software-Defined Optical Networks

OBS over WSON is one of the promising paradigms for future optical networks, which offers statistical multiplexing over high speed optical networks while eliminating electronic bottlenecks. In such legacy IP/WDM networks, control planes at IP and WDM layers are independently operated and managed, which may not optimize network performance. Recently, OpenFlow-based Software Defined Network (SDN) architecture is introduced, which enables unified control protocols for multi-layer networks to improve network agility and automation while reducing capital and operational expenditures. In this paper, we introduce a Software Defined Optical Network (SDON) architecture and develop a QoS-aware unified control protocol for optical burst switching in OpenFlow-based software-defined optical networks. A novel adaptive-burst assembling algorithm, a latency-aware burst routing and scheduling algorithm, and an effective OpenFlow-based signaling protocol are investigated. The performance of the proposed protocol is evaluated with a well-known GMPLS-based distributed protocol. The proposed QoS-aware unified control protocol significantly improves burst blocking, network throughput, and packet latency while offering better quality of service (QoS) to different classes of traffic with heterogeneous delay requirements compared to the GMPLS-based distributed protocol.
The dice are rolling for schizophrenia genetics.

Professor Tim Crow’s impassioned review (Crow, In press) addresses the question at the heart of schizophrenia (SCZ) genetics: a decade into the genomic era and after at least 28 genomewide linkage studies (Konneker et al., Submitted), ~1300 association studies of ~700 candidate genes (Allen et al., In press), and three published genomewide association studies (GWAS) (Lencz et al., 2007, Shifman et al., 2008, Sullivan et al., In press), what do we truly know about the genetics of SCZ?
Intracranial taser dart penetration: Literature review and surgical management

We report the case of a fourteen-year-old female who obtained TASER dart penetration to her right parietal region. She was neurologically intact with headache. CT scan of the head demonstrated TASER penetration intracranially without hemorrhage. Attempts were made at sterile removal of TASER at bedside under sedation. This caused the TASER to break at multiple points leaving only an intracranial component. She was urgently taken to the operating room for craniectomy for TASER removal. After reviewing the literature of an additional two patients, we suggest patients should not have attempts at removing device at bedside and should be taken to the operating room for adequate removal and washout.
Analysis of an error control protocol for spread spectrum communication networks

The authors evaluate the performance of spread spectrum multiple access packet radio networks under a simple hybrid-ARQ (automatic-repeat-request) scheme using convolutional encoding and Viterbi decoding with repeat request. This scheme can achieve improved reliability with only a slight degradation in throughput. A shorter length of chip sequences (or frequency hopping patterns) or a required smaller transmitting power can be implemented under this scheme while still accomplishing the desired reliability. The retransmission and additional delay can be controlled by adjusting a threshold level. This hybrid scheme offers a more flexible set of parameters from which individual users can choose. The evaluation of packet error probability, throughput, and delay is investigated and numerically presented. >
The effects of physical activity on attention deficit hyperactivity disorder symptoms: The evidence

Evidence supports the beneficial effects of physical activity (PA) on cognitive performance and suggests that effects might be particularly large for children. However, limited research has explored PA as a means of managing behavioral symptoms and improving cognitive performance of children with attention deficit hyperactivity disorder (ADHD). The etiology of ADHD and the putative mechanisms for the effects of PA on cognitive performance suggest that PA might be especially important for this population.
The Seismogenic Zone of Subduction Thrust Faults

This book is essentially B.S.—Before Sumatra. Before December 26, 2004, when part of the thrust fault interface between the subducting Indian and overriding Burma plates off the coast of Sumatra broke. Before the rupture raced 1,200 km northward at 10,000 km/hr (Mach 8). Before an area of the subducting plate comparable to that of California moved 10 meters, causing a magnitude 9.3 earthquake that was the largest in 40 years. Before the resulting seafloor motion generated a tsunami that crossed the Indian Ocean at the speed of a jetliner and killed more than 200,000 people. Is a B.S.—Before Sumatra—book about subduction zones still useful? The almost unbelievable size of this earthquake and its effects brought home how little we still know about the physics of the subduction zone interface where large earthquakes including the rare giant (M 9) earthquakes occur. (As part of efforts to entice students into the earth sciences we might call these “extreme” or “X-quakes.”) Two previous giant earthquakes, off Chile in 1960 and Alaska in 1964, occurred just before the discovery of plate tectonics explained that such earthquakes occur when years of strain …
Personal dose equivalent conversion coefficients for neutron fluence over the energy range of 20-250 MeV.

Monte Carlo simulations were performed to extend existing neutron personal dose equivalent fluence-to-dose conversion coefficients to an energy of 250 MeV. Presently, conversion coefficients, H(p,slab)(10,alpha)/Phi, are given by ICRP-74 and ICRU-57 for a range of angles of radiation incidence (alpha = 0, 15, 30, 45, 60 and 75 degrees ) in the energy range from thermal to 20 MeV. Standard practice has been to base operational dose quantity calculations 20 MeV. Both light and heavy ions (HIs) (carbon, nitrogen and oxygen recoil nuclei) were transported down to a lower energy limit (1 keV for light ions and 5 MeV for HIs). Track energy below the limit was assumed to be locally deposited. For neutron tracks <20 MeV, kerma factors were used to obtain absorbed dose. Results are presented for a discrete set of angles of incidence on an ICRU tissue slab phantom.
Management of HIV-associated lipodystrophy: Medical and surgical options for lipoatrophy and lipohypertrophy

Over 25 years after the first published cases of the acquired immunodeficiency syndrome in 1981, human immunodeficiency virus (HIV) has infected an estimated 65 million people and resulted in at least 25 million deaths [1]. During the latter part of the 1990s, potent HIV therapies became available and produced a dramatic improvement in the prognosis of this fatal viral illness. Suppression of viral replication by highly active antiretroviral therapies (HAART) and subsequent increases in CD4+ cell count have yielded increases in disease-free survival. The benefits of HAART, however, have been tempered by the development of metabolic complications and morphologic changes in patients receiving these therapies, which may occur in 10–60% of this population [2].
Visual attention toward tourism photographs with text: An eye-tracking study

Abstract This study examines consumers' visual attention toward tourism photographs with text naturally embedded in landscapes and their perceived advertising effectiveness. Eye-tracking is employed to record consumers' visual attention and a questionnaire is administered to acquire information about the perceived advertising effectiveness. The impacts of text elements are examined by two factors: viewers' understanding of the text language (understand vs. not understand), and the number of textual messages (single vs. multiple). Findings indicate that text within the landscapes of tourism photographs draws the majority of viewers' visual attention, irrespective of whether or not participants understand the text language. People spent more time viewing photographs with text in a known language compared to photographs with an unknown language, and more time viewing photographs with a single textual message than those with multiple textual messages. Viewers reported higher perceived advertising effectiveness toward tourism photographs that included text in the known language.
Lay Conceptions of Volitional Personality Change: From Strategies Pursued to Stories Told

Recent research suggests that individuals play an active role in their own personality development. Here, we investigated lay conceptions of this volitional personality change process. In Study 1, participants (N = 602) provided open-ended descriptions of their desired personality changes as well as the strategies they were using to achieve these changes. In Study 2, participants (N = 578) completed these same measures and provided narrative descriptions of the emergence of their desires for (and previous) personality changes. Desired changes were quantified in a manner consistent with the Five-Factor Model (though desires pertinent to Openness to Experience were rare), whereas reported strategies were distinguished on the basis of cognitive and behavioral content. Desires to increase in Extraversion corresponded negatively with the use of cognitive strategies and positively with the use of behavioral strategies, whereas desires to increase in Agreeableness exhibited the opposite pattern. Finally, desires for change were typically construed as stimulated by specific events, whereas previous personality changes were attributed to shifts in social roles. Laypersons hold a diverse range of desired changes and strategies. In addition, different categories of events are recognized as catalysts of desires for (and previous) changes.
Human Trafficking Violates Anti-Slavery Provision: Introductory Note to Rantsev v. Cyprus and Russia - European Court of Human Rights

In a landmark judgment, the European Court of Human Rights ruled unanimously in Rantsev v. Cyprus and Russia that human trafficking violates Article 4 (prohibition of slavery, servitude and forced labor) of the European Convention on Human Rights. Although the Court had held in an earlier case that trafficking of a child domestic worker fell within the scope of Article 4, this is the first case in which it has addressed sex trafficking under that provision. This Introductory Note, which will appear in Volume 49 of International Legal Materials, provides an overview of the case and comments on the significance of the judgment.
Pharmacokinetics of ranitidine in morbidly obese women.

Virtually all patients who are under the physiologic stress of an intensive care unit (ICU) are vulnerable to stress-related mucosal damage and ulceration. Although clinically significant hemorrhage from stress ulceration occurs in only 5-20 percent of patients in the ICU, the associated mortality is greater than 50 percent. The pathophysiologic mechanisms of stress ulcer are not well understood; however, a number of risk factors such as intraluminal gastric acidity and mucosal ischemia have been implicated. To prevent the development of stress ulcers and subsequent complications, it is important to identify and correct these underlying risk factors. Improving mucosal blood flow (i.e., fluid resuscitation and low-dose dopamine) and providing adequate nutritional support are invaluable adjuncts in minimizing the risk of stress ulcer formation. The use of pharmacologic prophylaxis controls the gastric acidity and prevents the formation of stress ulcers. The potential for drug-induced adverse effects and drug-drug interactions are of particular concern in the care of critically ill patients. Multiple organ system dysfunction or failure, malnutrition, fluid and electrolyte abnormalities, as well as the use of multiple pharmacologic agents predispose these patients to alterations in drug pharmacokinetics, drug-induced adverse effects and drug-drug interactions. These changes may alter the pharmacodynamic response to therapy and must be considered when designing drug dosage regimens for critically ill patients.
Some new chemotherapeutic agents reported useful in psychiatric practice.

The newer psychopharmacologic agents facilitate the control of nervous and mental illness but are not a substitute for proper physical, mental or social adjustment of the patient. They are best used as a supplement to other direct measures aimed at obtaining a cure. All of them may produce troublesome, even dangerous side effects or complications.
Niche-Specific Impact of a Symbiotic Function on the Persistence of Microbial Symbionts within a Natural Host.

ABSTRACT How the function of microbial symbionts is affected by their population/consortium structure within a host remains poorly understood. The symbiosis established between Euprymna scolopes and Vibrio fischeri is a well-characterized host-microbe association in which the function and structure of V. fischeri populations within the host are known: V. fischeri populations produce bioluminescence from distinct crypt spaces within a dedicated host structure called the light organ. Previous studies have revealed that luminescence is required for V. fischeri populations to persist within the light organ and that deletion of the lux gene locus, which is responsible for luminescence in V. fischeri, leads to a persistence defect. In this study, we investigated the impact of bioluminescence on V. fischeri population structure within the light organ. We report that the persistence defect is specific to crypt I, which is the most developmentally mature crypt space within the nascent light organ. This result provides insight into the structure/function relationship that will be useful for future mechanistic studies of squid-Vibrio symbiosis. In addition, our report highlights the potential impact of the host developmental program on the spatiotemporal dynamics of host-microbe interactions. IMPORTANCE Metazoan development and physiology depend on microbes. The relationship between the symbiotic function of microbes and their spatial structure within the host environment remains poorly understood. Here we demonstrate, using a binary symbiosis, that the host requirement for the symbiotic function of the microbial symbiont is restricted to a specific host environment. Our results also suggest a link between microbial function and host development that may be a fundamental aspect of the more complex host-microbe interactions.
Technology Adoption in Hospitals – The Roles of System Integration and Technology Support

This research studies how hospital employees react to new HIT systems with an attention to the special IT environment of hospital operations. Two characteristics of the IT environment, system integration and technology support, are identified as contextual constraints that shape the adoption of new HIT systems. A research model is developed based on the established IS theory of the Technology Acceptance Model (TAM). A field study was conducted by surveying employees from two hospitals. The research model is tested and results are discussed.
Towards An Analysis of Study Habits of College Students

The current comparative study investigated the study habits of youth studying Diploma in Electrical and Electronic Engineering and Diploma in Mechanical Engineering in the private polytechnic college, Anguchettipalayam, Kadalur Dist., The purpose of this study was to compare and find out the study habits of youth. The respondents were from the age group of 16-25 years. The sample was composed of 180students (90 students from D.E.E.E. and 90 students from D.M.E.) and they were selected through convenience sampling. A standardized tool of C. Gilbert Wrenn’sstudy habits inventory was administered for data collection. The collected data was analyzed by SPSS20. The study revealed that overall in both the group students didn’t have good study skills.
Neither East Nor West: Ukraine's Security Policy Under Kuchma

Ukrainian security policy under Kuchma had no ideological foundation. As a result, Kuchma flip-flopped on Western integration to suit his personal interests.
A study on the life quality of patients with condyloma acuminatum and correlated factors

Objective To evaluate the quality of life and correlated factors in patients with condyloma acuminatum (CA). Methods 101 patients with CA and 50 healthy people as control were assessed by using the questionnaire of QOL-35. Results Compared with control group, the total score and general, physical, inde-pendence, psychological, social, environment domains scores of QOL were lower significantly in the CA group ( P <0.05). The QOL score has negative correlation with course of disease( r= -0.233, P<0.05), recurrence times(r= -0.556, P<0.05). Nevertheless, it has no noticeable correlation with gender, age, marital status, education, career (P0.05). Conclusion Quality of life was lower in patients with CA, and it was closely related with the course of disease and recurrence times. Key words: Condyloma aeuminatum; Life quality; Correlated factors
Optimizing Players' Expected Enjoyment in Interactive Stories.

In interactive storytelling systems and other story-based computer games, a drama manager is a background agent that aims to bring about an enjoyable and coherent experience for the players. In this paper, we present a personalized drama manager that increases a player’s expected enjoyment without removing player agency. Our personalized drama manager models a player’s preference using data-driven techniques, predicts the probability the player transitioning to different story experiences, selects an objective experience that can maximize the player’s expected enjoyment, and guides the player to the selected story experience. Human study results show that our drama manager can significantly increase players’ enjoyment ratings in an interactive storytelling testbed, compared to drama managers in pre-
Resistance training reduces inflammation and fatigue and improves physical function in older breast cancer survivors

OBJECTIVE Resistance training (RT) reduces fatigue and improves physical function and quality of life (QOL) in breast cancer survivors (BCS). This may be related to reductions in systemic and tissue-specific inflammation. This pilot study examines the hypothesis that RT induces changes in systemic and tissue-specific inflammation that contribute to improvements in physical and behavioral function in postmenopausal BCS. METHODS Eleven BCS (60 ± 2 years old, body mass index 30 ± 1 kg/m, mean ± SEM) underwent assessments of fatigue (Piper Fatigue Scale), physical function, QOL (SF-36), glucose and lipid metabolism, and systemic, skeletal muscle, and adipose tissue inflammation (n = 9) before and after 16 weeks of moderate-intensity whole-body RT. RESULTS Muscle strength improved by 25% to 30% (P < 0.01), QOL by 10% (P = 0.04), chair stand time by 15% (P = 0.01), 6-minute walk distance by 4% (P = 0.03), and fatigue decreased by 58% (P < 0.01), fasting insulin by 18% (P = 0.04), and diastolic and systolic blood pressure by approximately 5% (P = 0.04) after RT. BCS with the worst fatigue and QOL demonstrated the greatest improvements (absolute change vs baseline: fatigue: r = -0.95, P < 0.01; QOL: r = -0.82, P < 0.01). RT was associated with an approximately 25% to 35% relative reduction in plasma and adipose tissue protein levels of proinflammatory interleukin (IL)-6sR, serum amyloid A, and tumor necrosis factor-α, and 75% relative increase in muscle pro-proliferative, angiogenic IL-8 protein content by 75% (all P < 0.05). BCS with the highest baseline proinflammatory cytokine levels had the greatest absolute reductions, and the change in muscle IL-8 correlated directly with improvements in leg press strength (r = 0.53, P = 0.04). CONCLUSIONS These preliminary results suggest that a progressive RT program effectively lowers plasma and tissue-specific inflammation, and that these changes are associated with reductions in fatigue and improved physical and behavioral function in postmenopausal BCS.
Hemophagocytic lymphohistiocytosis and pulmonary alveolar proteinosis in a 13-month-old boy with lysinuric protein intolerance

Hemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome that can be inherited or acquired. Herein, we report a case of HLH and pulmonary alveolar proteinosis (PAP) in the setting of lysinuric protein intolerance (LPI) in a male toddler who presented with prolonged fever, respiratory distress, and failure to thrive. On histologic examination, hemophagocytosis was observed in lymph node, bone marrow sections and aspirates. Lung wedge resection was consistent with PAP. LPI was confirmed with genetic sequencing which revealed compound heterozygous mutations in the SLC7A7 gene. LPI is a rare inborn error of metabolism and is not widely known beyond the pediatric group. Though the association of LPI with HLH has been previously described, we believe this is the first reported case of HLH and PAP associated LPI with histopathological correlation. Early recognition of HLH is critical to successful treatment and LPI should be considered in any young infant who presents with HLH- and PAP-related symptoms.
Is Tall-1 a trimer or a virus-like cluster?

Our conclusion that a 60-meric soluble-TALL-1 cluster is the functional unit of this ligand1,2 is based on several lines of evidence.
Colossians 1:24 and the Suffering Church:

The essay begins with an analysis of the major interpretations of Paul's claim to “complete what is lacking in Christ's afflictions.” The author argues that, in the context of Colossians, these aff...
Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity

Chemical exposures have been implicated as environmental risk factors that interact with genetic susceptibilities to influence individual risk for complex neurodevelopmental disorders, including autism spectrum disorder, schizophrenia, attention deficit hyperactivity disorder and intellectual disabilities. Altered patterns of neuronal connectivity represent a convergent mechanism of pathogenesis for these and other neurodevelopmental disorders, and growing evidence suggests that chemicals can interfere with specific signaling pathways that regulate the development of neuronal connections. There is, therefore, a growing interest in developing screening platforms to identify chemicals that alter neuronal connectivity. Cell-cell, cell-matrix interactions and systemic influences are known to be important in defining neuronal connectivity in the developing brain, thus, a systems-based model offers significant advantages over cell-based models for screening chemicals for effects on neuronal connectivity. The embryonic zebrafish represents a vertebrate model amenable to higher throughput chemical screening that has proven useful in characterizing conserved mechanisms of neurodevelopment. Moreover, the zebrafish is readily amenable to gene editing to integrate genetic susceptibilities. Although use of the zebrafish model in toxicity testing has increased in recent years, the diverse tools available for imaging structural differences in the developing zebrafish brain have not been widely applied to studies of the influence of gene by environment interactions on neuronal connectivity in the developing zebrafish brain. Here, we discuss tools available for imaging of neuronal connectivity in the developing zebrafish, review what has been published in this regard, and suggest a path forward for applying this information to developmental neurotoxicity testing.
A case study in the identification of prosodic cues to turn-taking: Back-channeling in arabic

Discovering and quantifying the prosodic signals that help manage turn-taking is difficult, in part because of the limitations of commonly used methods. This paper presents an integrated method that uses both perceptually-based analysis and quantitative analysis. The eight activities involved in the method — clarification of aims, problem formulation, corpus preparation, feature discovery, feature combination, hypothesis refinement, tuning, and evaluation — are illustrated using task of finding prosodic cues for back-channel feedback in Arabic.
Applications of Video-Conferencing Technology in Special Education Teacher Preparation

Teacher educators must find ways to teach course content situated within realistic K-12 contexts so that their preservice teachers can better understand how to apply that content effectively in sit...
A peculiar case of caudal abnormality inhemidactylus flaviviridis rüppel

The case of caudal abnormality described here is the first of its type and differs from all the previous records of such abnormalities in lizards-A complete account of its external appearance, scalation and skeleton is given, as well as some observations made on the musculature of the regenerated region. The author tries to interpret, as far as possible, how the growing tail must have been injured to produce such a peculiar abnormality. The cartiliginous tube is of a sinuous type and is peculiarly disposed, giving off a very small branch on the right side about the middle of its length.
Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23).

Deletions of the long arm of chromosome 6 have been described in acute and chronic lymphocytic leukemia (ALL and CLL) and prolymphocytic leukemia (PLL), and have been associated with t(14;18)(q32;q21) in non-Hodgkin's lymphoma (NHL). Of 55 cases of small lymphocytic (sm lym) NHL, deletions of 6(q21q23) were the most common recurring cytogenetic abnormality. Among 14 sm lym NHL with del(6)(q21q23), this abnormality occurred as a solitary change in 3 cases. Each of these 3 cases, and 5 additional cases with del(6q) and other abnormalities, showed atypical larger forms with the morphologic appearance of prolymphocytes or paraimmunoblasts in the peripheral blood. In comparison, of the 11 cases without del(6q) and circulating abnormal cells, prolymphocytoid forms were observed in 4 cases (P < .001). Of the 31 sm lym without del(6q), trisomies of chromosomes 3, 12, or 18, or t(11;14)(q13;q32) occurred in greater than 10% of cases. Proliferation centers or infiltration by larger forms were observed in similar proportions of tissue sections derived from sm lym NHL with or without del(6q). The presence of the larger forms in the peripheral blood did not have an adverse prognostic impact on the survival of the del(6q) cohort, who experienced a median survival in excess of 6 years. All 14 cases of del(6q) sm lym NHL were characterized by a mature B-cell phenotype. Expression of CD11c, a feature of a CLL/PLL variant previously described, was not detected in 9 cases analyzed. In 5 cases of del(6q) sm lym NHL, no circulating abnormal lymphocytes were noted. Twelve cases presented with, or developed, clinical splenomegaly. These results suggest that deletion of a gene or genes at 6q21-23 is associated with the pathogenesis of a subset of B-cell sm lym NHL that may display larger prolymphocytoid cells in the peripheral blood, but that follows a clinical course typical of other well-differentiated lymphocytic neoplasms.
Conclusion: Toward a New Humanism

The conclusion offers reason to hope for a more unified progressive politics founded on a truly universal humanism—a revival on a cosmopolitan scale of an ideal first articulated in Western democracies that fell miserably short of realizing it. That hope is justified because—thanks to postmodernism, and in spite of the excesses it entailed—there could now be a truly representative diversity of voices involved. By appealing openly (and controversially) to educated elites—again, on a cosmopolitan scale—this vision challenges the young especially to take up an intellectual task, first of all. It invites those qualified to start from scratch and to ask again the ancient question: what is it to be human? What does it mean to be human? And it invites the same educated elites to step up and take responsibility for fashioning a political program founded on emerging answers to that ancient question, now being asked and answered in a cosmopolitan context. No one else can do it. It is their duty. And in the age of Trump in particular, and of know-nothing “autocratic populism” in general, in ascendency across the globe—it is a duty that could not be more urgent.
Fluctuations in cool quark matter and the phase diagram of quantum chromodynamics

We consider the phase diagram of hadronic matter as a function of temperature, $T$, and baryon chemical potential, $\ensuremath{\mu}$. Currently the dominant paradigm is a line of first order transitions which ends at a critical endpoint. In this work we suggest that spatially inhomogeneous phases are a generic feature of the hadronic phase diagram at nonzero $\ensuremath{\mu}$ and low $T$. Familiar examples are pion and kaon condensates. At higher densities, we argue that these condensates connect onto chiral spirals in a quarkyonic regime. Both of these phases exhibit the spontaneous breaking of a global $U(1)$ symmetry and quasilong range order, analogous to smectic liquid crystals. We argue that there is a continuous line of first order transitions which separate spatially inhomogeneous from homogeneous phases, where the latter can be either a hadronic phase or a quark-gluon plasma. While mean field theory predicts that there is a Lifshitz point along this line of first order transitions, in three spatial dimensions strong infrared fluctuations wash out any Lifshitz point. Using known results from inhomogeneous polymers, we suggest that instead there is a Lifshitz regime. Nonperturbative effects are large in this regime, where the momentum dependent terms for the propagators of pions and associated modes are dominated not by terms quadratic in momenta, but quartic. Fluctuations in a Lifshitz regime may be directly relevant to the collisions of heavy ions at (relatively) low energies, $\sqrt{s}/A:1\ensuremath{\rightarrow}20\text{ }\text{ }\mathrm{GeV}$.
Discourses of Exclusion: The Societal Securitization of Burma’s Rohingya (2012–2018):

AbstractThe contemporary persecution of Burma’s Rohingya has rapidly evolved from isolated episodes of communal violence into a global humanitarian crisis. The article analyses the evolution of the...
Levitation of a rapidly oscillating magnetic dipole above a metallic sheet

Abstract We show that such a magnetic dipole suspended at a height h above a conducting sheet experiences a lift force proportional to 1 / h 2 . This represents an order of magnitude improvement over the 1 / h 4 lift obtained in the quasistatic limit.
Abstract P015: Biomarkers Representing Key Aging-related Biological Pathways Are Associated With Subclinical Atherosclerosis: the Framingham Study

Background: Increased oxidative stress, telomere attrition, endothelial dysfunction and alterations in insulin-like growth factor-1 are key molecular mechanisms of aging. We hypothesized that bioma...
Prognostic implications of signet ring cell histology in esophageal adenocarcinoma: A SEER database analysis

4067 Background: Signet ring cell esophageal adenocarcinoma histology has been difficult to study in a single institution series because of its relative rarity, yet has an anecdotal reputation for ...
On corrected phase-type approximations of the time value of ruin with heavy tails

We approximate Gerber–Shiu functions with heavy-tailed claims in a recently introduced risk model having both interclaim times and premiums depending on the claim sizes. We apply a technique known as “corrected phase-type approximations”. This results in adding a correction term to the Gerber–Shiu function with phase-type claim sizes. The correction term contains the heavy-tailed behavior at most once per convolution and captures the tail behavior of the true Gerber–Shiu function. We make the tail behavior specific in the classical case of one class of risk insured. After illustrating a use of such approximations, we study numerically the approximations’ relative errors for some specific penalty functions and claims distributions.
Cutaneous manifestations of physical and sexual child abuse

This article reviews cutaneous manifestations of physical and sexual abuse and a stepwise approach that dermatologists can apply to differentiate abusive from accidental injuries.