cssi/SciSciGPT-SciSciNet huggingface dataset:
Divergent selection for postweaning feed conversion in Angus beef cattle: II. Genetic and phenotypic correlations and realized heritability estimate.

A single generation divergent selection study, replicated four times (1983, 1984, 1985, and 1986), was conducted to assess genetic differences between progeny of high and low feed conversion sires in Angus beef cattle and to determine correlated response for weight gain (ADG140), feed intake (AVFD140), and BW (OFFTSTWT) in a time- (140-d) and fat-constant (8.9 mm) period. Realized heritability estimates for unadjusted (feed/gain; FEFF140; .26) and adjusted feed conversion (adjusted as recommended by the BIF, 1986; ADJFDEFF; .46) were obtained. The difference in heritability estimates reflects variation accounted for by adjustment for BW differences, and thus maintenance requirements, of individual progeny. Phenotypic and "pseudo" realized genetic correlations of FEFF140 with ADG140, AVFD 140, and OFFTSTWT were -.33 and -.66, .49 and -.26, and .15 and -.41, respectively. Phenotypic and "pseudo" realized genetic correlations of ADJFDEFF with ADG140, AVFD140, OFFTSTWT, and FEFF140 were -.54 and -.59, .30 and -.23, .27 and -.36, and .97 and .49, respectively. Subcutaneous fat (as estimated by ultrasonic measurement; BF140) had phenotypic and "pseudo" realized genetic correlations with FEFF140 of -.33 and .66, respectively, and with ADJFDEFF of -.44 and -.58, respectively.
Hydrocarbon Biodegradation and Oil Spill Bioremediation

Much of the early work on the microbial utilization of petroleum hydrocarbons, conducted in the 1950s and 1960s, was done with the goal of using hydrocarbons as substrates for producing microbial biomass (Shennan, 1984; Champagnat, 1964; Champagnat and Llewelyn, 1962; Cooney et al., 1980; Ballerini, 1978). Petroleum was viewed as an inexpensive carbon source and single cell protein (microbial biomass) was considered as a possible solution to the perceived impending world food shortage for the predicted global population explosion. Applied studies focused on optimizing microbial growth on low- to middle-molecular-weight hydrocarbons. These studies developed fermentor designs for large-scale single cell protein production with agitation and aeration systems that permitted high rates of microbial growth on soluble and highly emulsified hydrocarbon substrates. High-speed impellers (>800 rpm) were used to mix the hydrocarbon substrates and high rates of forced aeration with baffles within the fermentors were used to supply the molecular oxygen necessary for the microbial utilization of hydrocarbons (Hatch, 1975; Prokop and Sobotka, 1975). Optimized microbial growth in these fermentors consumes as much as 100,000 g hydrocarbon/m3 per day (Kanazawa, 1975).
Race/ethnicity and socio-economic differences in colorectal cancer surgery outcomes: analysis of the nationwide inpatient sample

The purpose of this study was to examine racial and socio-economic differences in the receipt of laparoscopic or open surgery among patients with colorectal cancer, and to determine if racial and socio-economic differences exist in post-surgical complications, in-hospital mortality and hospital length of stay among patients who received surgery. We conducted a cross-sectional analysis of hospitalized patients with a primary diagnosis of colorectal cancer between 2007 and 2011 using data from Nationwide Inpatient Sample. ICD-9 codes were used to capture primary diagnosis, surgical procedures, and health outcomes during hospitalization. We used logistic regression analysis to determine racial and socio-economic predictors of surgery type, post-surgical complications and mortality, and linear regression analysis to assess hospital length of stay. A total of 122,631 patients were admitted with a primary diagnosis of malignant colorectal cancer between 2007 and 2011. Of these, 17,327 (14.13 %) had laparoscopic surgery, 70,328 (57.35 %) received open surgery, while 34976 (28.52 %) did not receive any surgery. Black (36 %) and Hispanic (34 %) patients were more likely to receive no surgery compared with Whites (27 %) patients. However, among patients that received any surgery, there were no racial differences in which surgery was received (laparoscopic versus open, p = 0.2122), although socio-economic differences remained, with patients from lower residential income areas significantly less likely to receive laparoscopic surgery compared with patients from higher residential income areas (OR: 0.74, 95 % CI: 0.70-0.78). Among patients who received any surgery, Black patients (OR = 1.07, 95 % CI: 1.01-1.13), and patients with Medicare (OR = 1.16, 95 % CI: 1.11-1.22) and Medicaid (OR = 1.15, 95 % CI: 1.07-1.25) insurance experienced significantly higher post-surgical complications, in-hospital mortality (Black OR = 1.18, 95 % CI: 1.00-1.39), and longer hospital stay (Black β = 1.33, 95 % CI: 1.16-1.50) compared with White patients or patients with private insurance. Racial and socio-economic differences were observed in the receipt of surgery and surgical outcomes among hospitalized patients with malignant colorectal cancer in the US.
Interactions Between Advanced Age and HIV Cognitive Impairment

Moreover, it is often accompanied by a multitude of comorbidities, both medical and psychiatric. This is common in geriatric medicine and typically requires a multidisciplinary approach. Most older HIV patients acquired infection at a younger age and aged with HIV; however, older individuals also acquire infection in their sixth or older decade of life and remain an often hidden population.
Immobilized hepatic microsomes for the synthesis of glucuronides

A method has been developed for the direct immobilization of hepatic microsomes. The technique is simple and efficient. The immobilized microsomes retain biological activity and can be used to perform enzymatic reactions.
Transcatheter aortic valve implantation with a Sapien 3 Commander 20 mm valves in patients with degenerated 19 mm bioprosthetic aortic valve.

Introduction Transcatheter aortic valve implantation (TAVI) in patients with degenerated bioprosthetic aortic valve has been successfully performed as an alternative to surgery. We describe our initial experience of valve-in-valve TAVI in five patients, using new generation Edwards Sapien 3 transcatheter heart valves implanted into degenerated 19 mm bioprosthetic valves. 20-mm Edwards S3 valves were offered for compassionate use. All patients had significant aortic valve stenosis. Methods and Results The main vascular access was achieved and pre-closed with two Proglide closure devices in one patient and Prostar closure devices in four patients. For each TAVI procedure an Edwards 14 French sheath was inserted without complication and sutured in place. The Sapien 3 Commander delivery system was inserted and the valve was aligned in the descending aorta. The 20-mm Sapien 3 valve was deployed with slow continuous inflation during rapid right ventricular pacing. The cranial edge of the Edwards S3 valve was aligned with the cranial radiopaque markers of bioprosthesis to minimize paravalvular leak. Post-deployment angiography, transesophageal echocardiography and aortogram confirmed absence of mild aortic insufficiency and no increase in trans-aortic gradient when compared to a naive 19 mm bioprosthetic valve. Conclusion Valve-in-valve TAVI with the Edwards S3 transcatheter heart valve for degenerative bioprosthetic aortic valves is technically feasible. The proper position of the stented valve minimizes the risk for post-procedure paravalvular insufficiency and provides good transaortic pressure gradient. © 2016 Wiley Periodicals, Inc.
Cancer incidence and mortality risks in a large US Barrett's oesophagus cohort.

Objective Barrett9s oesophagus (BE) increases the risk of oesophageal adenocarcinoma by 10–55 times that of the general population, but no community-based cancer-specific incidence and cause-specific mortality risk estimates exist for large cohorts in the USA. Design Within Kaiser Permanente Northern California (KPNC), we identified patients with BE diagnosed during 1995–2012. KPNC cancer registry and mortality files were used to estimate standardised incidence ratios (SIR), standardised mortality ratios (SMR) and excess absolute risks. Results There were 8929 patients with BE providing 50 147 person-years of follow-up. Compared with the greater KPNC population, patients with BE had increased risks of any cancer (SIR=1.40, 95% CI 1.31 to 1.49), which slightly decreased after excluding oesophageal cancer. Oesophageal adenocarcinoma risk was increased 24 times, which translated into an excess absolute risk of 24 cases per 10 000 person-years. Although oesophageal adenocarcinoma risk decreased with time since BE diagnosis, oesophageal cancer mortality did not, indicating that the true risk is stable and persistent with time. Relative risks of cardia and stomach cancers were increased, but excess absolute risks were modest. Risks of colorectal, lung and prostate cancers were unaltered. All-cause mortality was slightly increased after excluding oesophageal cancer (SMR=1.24, 95% CI 1.18 to 1.31), but time-stratified analyses indicated that this was likely attributable to diagnostic bias. Cause-specific SMRs were elevated for ischaemic heart disease (SMR=1.39, 95% CI 1.18 to 1.63), respiratory system diseases (SMR=1.51, 95% CI 1.29 to 1.75) and digestive system diseases (SMR=2.20 95% CI 1.75 to 2.75). Conclusions Patients with BE had a persistent excess risk of oesophageal adenocarcinoma over time, although their absolute excess risks for this cancer, any cancer and overall mortality were modest.
Categorization of survival and death after cardiac arrest

Abstract Background Most cardiac arrest (CA) patients remain comatose post-resuscitation, prompting goals-of-care (GOC) conversations. The impact of these conversations on patient outcomes has not been well described. Methods Patients (n = 385) treated for CA in Columbia University ICUs between 2008–2015 were retrospectively categorized into various modes of survival and death based on documented GOC discussions. Patients were deemed “medically unstable” if there was evidence of hemodynamic instability at the time of discussion. Cerebral performance category (CPC) greater than 2 was defined as poor outcome at discharge and one-year post-arrest. Results The survival rate was 31% (n = 118); most commonly after early recovery without any discussions (57%, n = 67), followed by survival due to family wishes despite physicians predicting poor neurological prognosis (20%, n = 24), and then survival after physician/family agreement of favorable prognosis (17%, n = 20). The survivors due to family wishes had significantly worse outcomes compared to the early recovery group (discharge: p = 0.01; one-year: p = 0.06) and agreement group (p Conclusions Most survivors due to family wishes despite poor neurological prognosis die or have poor outcomes at one-year. However, a small number achieve favorable recovery, demonstrating limitations with current prognostication methods. Among nonsurvivors, most WLST occurs while medically unstable, suggesting an overestimation of WLST due to unfavorable neurological prognosis.
Patterns of Myopia in the Barbados Eye Study

Population-based data on myopia in black adults are limited. The Barbados Eye Study (BES) is a population-based epidemiologic study that investigated major eye diseases in a large, predominantly black population. The BES included 4709 Barbados-bom citizens (84% of those eligible), ranging in age between 40 and 84 years. This report describes the frequency of myopia by self-reported race and presents the age-and sex-specific prevalence of myopia, as well as of high myopia, among BES black participants. b myopia were defined as spherical equivalents < −0.5 and < −6.0 diopters, respectively, based on data obtained through non-cycloplegic automated refraction. Analyses included the right eyes of 4036 black participants, after excluding individuals with a prior hi of cataract s The overall prevalence of myopia was 21.9%; men had a higher frequency of my; r women (25.0% vs. 19.5%, P.< 0.001). Among BES black males, the prevalence d from 19% at ages 40–49 years to 15% at ages 50–59 years but increased over the age c f 0 years. A similar pattern was noted in women. These age-specific patterns persisted even after eyes with visual acuity (VA) 20/40 or worse were excluded from the anal). I e overall prevalence of high myopia in black participants was 2.3%; a similar pattern of increasing prevalence after 60 years of age was noted. The age-specific patterns of myopia prevalence in the BES black population are different from those reported in other studies.
Abstract P253: Transcriptional Regulation of the IGFBP-1 Gene by RTEF-1 in Endothelial Cells

Background and Objective: Cardiovascular disease is the most important complication of type 2 diabetes, however, its underlying mechanism(s) are poorly understood. Our lab previously reported that RTEF-1 is a transcription factor that promotes angiogenesis via up-regulating HIF-1α and VEGF. In addition to these studies, we recently determined that RTEF-1 upregulates insulin-like growth factor binding protein-1 (IGFBP-1) expression in endothelial cells in vitro and in vivo. IGFBPs are key regulators of insulin-like growth factor (IGF) type 1 and 2 bioavailability at the cellular level. In addition, IGFBP-1 is implicated in cardiovascular health, in terms of blood pressure and glucose tolerance. Methods and Results: RTEF-1 upregulates IGFBP-1 expression in endothelial cells in vitro and in vivo through selectively binding and promoting transcription from the insulin response element (IRE) site on the IGFBP-1 promoter, demonstrated by ChIP assays. In addition to insulin inhibition of IGFBP-1 levels, insulin also dose-dependently inhibits RTEF-1 promoter activity (-2.4 ± 0.3-fold) and expression. In vivo data suggest that Tie2-Cre:RTEF-1 flox/flox transgenic mice, RTEF-1 EC-specific knockout mice, show a significant decrease decrease in IGFBP-1 mRNA levels compared with controls (0.21 ± 0.09 vs. 1.0, respectively), while VE-Cadherin/RTEF-1 overexpressing transgenic mice have increased IGFBP-1 mRNA levels (25.4 ± 0.02-fold). Increased IGFBP-1 levels relate physiologically in our RTEF-1 EC-specific knockout by showing decreased blood glucose tolerance as well as increased insulin resistance as calculated by HOMA-IR compared with littermate controls, (4.1 ± 0.5 vs. 1.1 ± 0.2, respectively). Furthermore, the RTEF-1 EC-specific knockout mice showed a significant increase in systolic blood pressure (10mmHg ± 6mmHg) compared with littermate controls. Conclusion: These results demonstrate that RTEF-1-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 attenuates blood glucose levels and potential cardiovascular function. These findings provide the basis for novel insights into transcriptional regulation of IGFBP-1 and contribute to understanding the role of vascular endothelial cells in metabolism.
Feedback From Internship Mentors in Technical Communication Internships

Documenting and characterizing interactions between student interns and their mentors in the workplace offers perspective on student learning and enculturation that can help us introduce these ways...
Surface modification of Ti64 through hydrothermal treatment in urea solutions

Abstract This study aims to modify Ti64 surface to improve its potential bioactivity and wear resistance. The polished Ti64 surfaces were hydrothermally treated in urea solutions with or without the subsequent heat treatment. Hydrothermal treatment increases the hydrophilicity and Vickers hardness of Ti64 surface. Heat treatment deteriorates the hydrophilicity of Ti64 surface although it enhances the surface hardness. Hydrothermal treatment on a polished Ti64 surface in 3 M urea solution achieves a crack-free and crystallized titania film while still retaining its negatively charged surface with high wettability.
Finding a community in the lab.

It is a rite of passage for every college student: English 101. The class began with introductions. At 28 years old, I knew that I would be older than the average student. After almost failing out of high school, I had enlisted in the U.S. Navy and spent the next 8 years operating the nuclear
A Satisficing, Negotiated, and Learning Coalition Formation Architecture

In this chapter, we present a multiagent system architecture for dynamic coalition formation and coalition strategy learning in a realtime multisensor target tracking environment. Agents operate autonomously, and they have incomplete information about their potential collaborators. In addition, accurate target tracking requires that multiple agents recognize and synchronize their actions-collecting measurements on the same target within the same time frame. Therefore some form of cooperation is necessary. In our system, agents form coalitions via multiple 1-to-l negotiations. However, due to the noisy and uncertain properties of the environment, coalitions formed can be only suboptimal and satisficing. To better adapt to changing requirements and environment dynamics, each agent is capable of multiple levels of learning. Each learns about how to negotiate better (case-based learning) and how to form a coalition better (reinforcement learning). To increase the chance of reaching a high-quality negotiated deal, our work also addresses issues in task allocation and dynamic utility-based profiling.
Coagulation monitoring during extracorporeal membrane oxygenation: The role of thrombelastography

Patients undergoing extracorporeal membrane oxygenation (ECMO) are at an increased risk for developing coagulopathies due to the adverse effects of extracorporeal circulation on the hemostatic mechanism. Methods of determining causative factors of bleeding diathesis are often inconsistent and non-specific. ECMO patients require aggressive transfusion therapy with autogenic blood products to stabilize and maintain hemostasis. The present study evaluated the coagulation status of newborn patients undergoing ECMO therapy, using a viscoelastic monitor (Thrombelastograph -TEG) that measures functional aspects of clot development and stabilization. Seventeen neonatal patients undergoing ECMO for severe respiratory dysfunction were entered into this study. Serial blood samples were obtained and routine coagulation assessment including fibrinogen concentration, platelet count and ionized calcium was performed. In addition, fibrin(ogen) degradation products (FDP), d-Dimers, antithrombin III and plasma free hemoglobin were measured. Transfusion indicators were established and total transfusion requirements recorded. TEG profiles were determined with the use of heparinase, an enzyme that degrades heparin but has little effect on other coagulation factors. The most commonly encountered complication was hemorrhaging which was diagnosed by laboratory and clinical assessment in 11 of 17 patients. Transfusion requirements (measured in ml/kg/ECMO hour) were the following: packed red blood cells--1.34 +/- 0.5; platelets--0.71 +/- 0.57; fresh frozen plasma--0.09 +/- 0.12; cryoprecipitate 0.05 +/- 0.05. Thrombelastograph profiles reflected hemostatic conditions that ranged from severe coagulopathies (DIC) to hypercoagulability. Interpretation of TEG profiles identified hemostatic abnormalities in 57 of 101 profiles (46.5%), with the most common etiology related to platelet dysfunction.(ABSTRACT TRUNCATED AT 250 WORDS)
Target N/Z Effects on Projectile Fragmentation

Peripheral reactions of 28Si with 112Sn and 124Sn at 30,40 and 50 MeV /­nucleon were used to elucidate the effect of the neutron content of the target on the process of projectile fragmentation. It is demonstrated that the fragments that result from these projectile fragmentation reac­tions can be divided into those which are the result of statistical emission of the quasi-projectile and those that are part of a direct component. The statistical part is independent of the target whereas the isotopic composition of fragments from the direct component are dependent on the neutron content of the target.
Canada’s early contributions to plasmonics

The field of plasmonics — the study of collective electron excitation in nanostructured metal and other conductors — is currently highly active with research foci in a number of related fields, inc...
Осмысливая феномен мягких бюджетных ограничений (Окончание)

The phenomenon of the soft budget constraint (SBC) in a competitive environment is analyzed in the second part of the article. Its consequences for banks and the role played in developing financial crises are considered. Political intervention in firms is studied. The conclusion is made that the SBC syndrome can arise in any economic system.
Lung Cancer Evolution: What's Immunity Got to Do with It?

During the development and progression of tumors, cancer cells undergo clonal selection due to a variety of genetic and microenvironmental factors. A recent report presents insights demonstrating the interplay between neoantigens and the immune system in untreated non-small-cell lung cancers.
MRI of common penile pathologies and penile prostheses

MRI can delineate finer details of penile anatomy and pathology due to inherent higher soft-tissue contrast and spatial resolution. It can characterize inflammation and identify abscesses, localize penile fractures, guide surgical planning in penile fibrosis and Peyronie's disease, and depict components of the penile prosthesis and its complications. MRI is a great investigative tool for penile neoplasms, including locally infiltrative neoplasms where clinical examination is limited, and local staging is crucial for surgical planning.
The influence of biological sex and sex hormones on bile acid synthesis and cholesterol homeostasis

Obesity and elevated serum lipids are associated with a threefold increase in the risk of developing atherosclerosis, a condition that underlies stroke, myocardial infarction, and sudden cardiac death. Strategies that aim to reduce serum cholesterol through modulation of liver enzymes have been successful in decreasing the risk of developing atherosclerosis and reducing mortality. Statins, which inhibit cholesterol biosynthesis in the liver, are considered among the most successful compounds developed for the treatment of cardiovascular disease. However, recent debate surrounding their effectiveness and safety prompts consideration of alternative cholesterol-lowering therapies, including increasing cholesterol catabolism through bile acid (BA) synthesis. Targeting the enzymes that convert cholesterol to BAs represents a promising alternative to other cholesterol-lowering approaches that treat atherosclerosis as well as fatty liver diseases and diabetes mellitus. Compounds that modify the activity of these pathways have been developed; however, there remains a lack of consideration of biological sex. This is necessary in light of strong evidence for sexual dimorphisms not only in the incidence and progression of the diseases they influence but also in the expression and activity of the proteins affected and in the manner in which men and women respond to drugs that modify lipid handling in the liver. A thorough understanding of the enzymes involved in cholesterol catabolism and modulation by biological sex is necessary to maximize their therapeutic potential.
Métodos de enseñanza comunicativos: El juego como estrategia didáctica en la instrucción del español como segunda lengua

Resumen El metodo mas efectivo para el aprendizaje no es aquel que suscita el acto de aglutinar ideas, sino aquel que promueve su creacion y recreacion (Freire, 1970). Asi mismo, y como senala Vygotsky (1978), el juego constituye una estrategia didactica versatil que promueve el desarrollo mental y estimula la construccion de conocimientos. El presente trabajo toma en cuenta los principios mas importantes de las teorias constructivistas de ensenanza-aprendizaje, dentro del marco de las metodologias comunicativas, con el objetivo de desarrollar una propuesta pedagogica basada en estrategias didacticas ludicas destinadas a la ensenanza del espanol a estudiantes universitarios de segunda lengua (L2). A traves de la descripcion teorico-analitica, a) se puntualizan los principales preceptos de las teorias constructivistas de Piaget, Ausubel y Vygotsky en el marco de la metodologia comunicativa de ensenanza de segundas lenguas; b) se senalan los aspectos fundamentales de las estrategias didactico-pedagogicas basadas en el aprendizaje a traves del juego; y c) se concluye con ejemplos de herramientas didacticas ludicas para la ensenanza del espanol como segunda lengua, disenadas en funcion de los conocimientos previos, el aprendizaje significativo y la interaccion social.
Comparing Managed Memory and ATS with and without Prefetching on NVIDIA Volta GPUs

One of the major differences in many-core versus multicore architectures is the presence of two different memory spaces: a host space and a device space. In the case of NVIDIA GPUs, the device is supplied with data from the host via one of the multiple memory management API calls provided by the CUDA framework, such as CudaMallocManaged and CudaMemCpy. Modern systems, such as the Summit supercomputer, have the capability to avoid the use of CUDA calls for memory management and access the same data on GPU and CPU. This is done via the Address Translation Services (ATS) technology that gives a unified virtual address space for data allocated with malloc and new if there is an NVLink connection between the two memory spaces. In this paper, we perform a deep analysis of the performance achieved when using two types of unified virtual memory addressing: UVM and managed memory.
Influence of ractopamine hydrochloride supplementation on pancreatic digestive enzyme activity in finishing steers

Sixty-nine finishing steers were randomly assigned to one of two treatment groups: supplementation to provide 0 or 267 mg·d−1 of ractopamine hydrochloride (RAC) for 42 d. Twelve steers were slaught...
Review of tau lifetime measurements

The measurements of the mean lifetime of the tau lepton are reviewed. The conditions for measuring the lifetime at various e+e- colliders are compared and the analysis methods are briefly described. The new developments since the previous Workshop on Tau Lepton Physics are listed. The world average is tau_tau = 290.5 +- 1.0 fs. The LEP experiments dominate this average and have analyzed nearly all of their data. In anticipation of the next era of precision measurements at CLEO and the b factories, the important sources of systematic errors and the treatment of systematic biases are discussed.
The role of institutional investors in pension risk transfers

Risk transfers represent a preferred method for removing pension liabilities from corporate balance sheet. We examine the role of institutional shareholders on firm’s decision to offload pension liabilities to professional risk managers. We find that the likelihood of pension risk transfers is higher for firms with higher level of institutional ownership and independent institutional owners. Firms with higher concentration of institutional ownership adopting a passive investment strategy are less likely to complete pension risk transfers. We also document the plan and sponsor-level factors affecting firms’ decision to undertake pension risk transfers.
Low Dose Interleukin-2 Induces Exosomes with Tolerance Markers (PDL1, CD73) and Significantly Delays Development of Chronic Rejection Following Murine Heterotopic Cardiac Transplantation

Purpose Aim of the study is to determine the effect of low dose interleukin-2 (IL-2) therapy on the kinetics of induction of circulating exosomes with tolerance markers (PDL1, CD73) and their role in abrogating chronic rejection following murine heterotopic cardiac transplant (HTx). Methods Allogenic (BALB/c to C57BL/6) HTx was performed heterotopically in abdominal cavity. Costimulatory blockade consisting of MR1 (250 μg/ip day 0) and CTLA4-Ig (200 μg/ip day 2) was performed. Low dose IL-2 (2000IU/day) was administered from day 15 post-transplant for 3 weeks. Sera was collected on days 7-100 for kinetic analysis of exosome induction and characterization of PDL1, CD73, cardiac self-antigens (SAgs) (Myosin, Vimentin), class II MHC trans-activator (CIITA), and 20S proteasome by western blot using specific antibodies (Abs) and Abs to SAgs. Results BALB/c to C57BL/6 HTx rejected transplanted heart with median survival time of 8 (7-9) days. HTx done following costimulatory blockade developed chronic rejection with mean survival time 26 (7-47) days. Exosome and Ab development demonstrated induction of exosomes with Vimentin (2.2± 1.0 vs 0.6±0.1; p Conclusion Circulating exosomes containing cardiac SAgs and development of Abs to SAgs lead to chronic rejection in a murine model occurring after costimulation blockade following allogenic HTx. Low dose IL-2 abrogated chronic rejection and induced circulating exosome with tolerance markers. This result supports an important role for exosomes, inducing tolerance and significantly delaying development of chronic rejection in murine model of chronic cardiac allograft rejection.
Modeling and Simulation of Inrush Currents in Harmonic Domain

Modeling and simulation capabilities are critical to the stability analysis and evaluation of power distribution systems, with respect to the emphasis on resiliency, microgrids, and distributed energy resources. In this paper, a computational method in the harmonic domain is proposed for the periodic steady-state analysis of the nonlinear inrush current phenomenon. The efficient inrush calculation facilitates the predictions of current amplitudes for the power system operation and control. To demonstrate the accuracy and efficiency, simulation results in the harmonic domain are compared with results from PSCAD in an electromagnetic timescale, as well as the authors' previous works in the frequency-domain. Impacts of the settings of both offset flux and interested harmonic order are discussed. In addition, within the proposed harmonic-domain method, a general approach that utilizes the discrete Fourier transform to obtain the response of a nonlinear device from a stimulus represented in the frequency-domain is utilized. This method can also be extended to perform the transient analysis in future, using trapezoidal rule for the integration.
Analysis and Characterization of Anti-Caking Additives Used in Rock Dust to Mitigate Mine Explosions

Experiments conducted with limestone dusts and dolomitic marble dusts have indicated that when rock dust is wetted and subsequently dried, it becomes a solid, non-dispersible cake. However, in order to be effectively inert a coal dust explosion, rock dust must be able to disperse as individual particles to air. To counteract this, rock dust manufacturers created treated rock dusts that will resist caking after moisture exposure. National Institute for Occupational Safety and Health (NIOSH) researchers conducted a series of laboratory-scale experiments on four base rock dusts and their treated counterparts to assess the effectiveness of various anti-caking additives after being exposed to moisture and then dried. The dusts were exposed to moisture using humidity cabinets having a high relative humidity (99% RH) and by also exposing the rock dust bed to water through bottom wicking. The dusts were then evaluated for dispersibility after drying using the NIOSH-designed dust dispersion chamber. The anti-caking additives were different concentrations of stearic acid, oleic acid, and xylene-based surfactants. All results were compared to a reference rock dust used to conduct large-scale experiments in the Lake Lynn Experimental Mine (LLEM), Fairchance, PA. When the untreated dusts were dried after exposure to moisture for 1 day, no dispersion was measured. However, rock dusts treated with anti-caking agents were readily dispersible even after exposure to moisture for 6 months. This report details the analysis and characterization of anti-caking additives using the NIOSH-designed dispersion chamber and the 20-L explosion test chamber.
Sales of private firms and the role of CEO compensation

Abstract We analyze the relation of private firms' CEO compensation with the probability of sale of a firm and its valuation at the time of the sale. Specifically, we study whether equity-based remuneration is consistent with compensating the CEO for effort related to selling the private firm, or with compensating for the illiquidity of the equity-based compensation for private firms. Using a sample of large private firms with public filings, we find that CEOs of IPO and acquired private firms have higher total and equity-based compensation than CEOs of firms that remain private. We also show that CEO compensation is positively related to the valuation premium of IPOs versus acquired firms.
Brief alcohol interventions with older adults: a systematic review of literature

The current systematic review analyzed empirical studies examining the effectiveness of brief alcohol interventions (BAI) for at-risk older adults. The authors independently reviewed the literature...
Excimer–monomer fluorescence changes by supramolecular disassembly for protein sensing and quantification

A protein binding-induced supramolecular dissociation strategy is developed with the ratio of monomer and excimer fluorescence as the tool for protein sensing and quantification. Due to the “lock-and-key” strategy based on specific ligand–protein binding, the probe exhibits excellent selectivity and quantification accuracy to the protein of interest. The ratiometric approach is immune to interference from extrinsic quenchers, while preserving the opportunity to be protein specific.
Revisiting TCP congestion control throughput models & fairness properties at scale

Much of our understanding of congestion control algorithm (CCA) throughput and fairness is derived from models and measurements that (implicitly) assume congestion occurs in the last mile. That is, these studies evaluated CCAs in "small scale" edge settings at the scale of tens of flows and up to a few hundred Mbps bandwidths. However, recent measurements show that congestion can also occur at the core of the Internet on inter-provider links, where thousands of flows share high bandwidth links. Hence, a natural question is: Does our understanding of CCA throughput and fairness continue to hold at the scale found in the core of the Internet, with 1000s of flows and Gbps bandwidths? Our preliminary experimental study finds that some expectations derived in the edge setting do not hold at scale. For example, using loss rate as a parameter to the Mathis model to estimate TCP NewReno throughput works well in edge settings, but does not provide accurate throughput estimates when thousands of flows compete at high bandwidths. In addition, BBR - which achieves good fairness at the edge when competing solely with other BBR flows - can become very unfair to other BBR flows at the scale of the core of the Internet. In this paper, we discuss these results and others, as well as key implications for future CCA analysis and evaluation.
Cost and Threshold Analysis of Positive Charge, a Multi-site Linkage to HIV Care Program in the United States

Positive Charge (PC) is a linkage to HIV care initiative implemented by AIDS United with sites in New York, Chicago, Louisiana, North Carolina, and the San Francisco/Bay Area. This study employed standard methods of cost and threshold analyses, as recommended by the US Panel on Cost-effectiveness in Health and Medicine, to calculate cost-saving and cost effective thresholds of the initiative. The overall societal cost of the linkage to care programs ranged from $48,490 to $370,525. The study found that PC’s five unique evidence-based linkage to care programs have relatively low costs per client served and highly achievable cost-saving and cost-effectiveness thresholds. The findings from this study suggest that HIV linkage to care programs have the potential to be a highly productive use of public health resources.
Rearrangement and evolution of mitochondrial genomes in parrots

Mitochondrial genome rearrangements that result in control region duplication have been described for a variety of birds, but the mechanisms leading to their appearance and maintenance remain unclear, and their effect on sequence evolution has not been explored. A recent survey of mitochondrial genomes in the Psittaciformes (parrots) found that control region duplications have arisen independently at least six times across the order. We analyzed complete mitochondrial genome sequences from 20 parrot species, including representatives of each lineage with control region duplications, to document the gene order changes and to examine effects of genome rearrangements on patterns of sequence evolution. The gene order previously reported for Amazona parrots was found for four of the six independently derived genome rearrangements, and a previously undescribed gene order was found in Prioniturus luconensis, representing a fifth clade with rearranged genomes; the gene order resulting from the remaining rearrangement event could not be confirmed. In all rearranged genomes, two copies of the control region are present and are very similar at the sequence level, while duplicates of the other genes involved in the rearrangement show signs of degeneration or have been lost altogether. We compared rates of sequence evolution in genomes with and without control region duplications and did not find a consistent acceleration or deceleration associated with the duplications. This could be due to the fact that most of the genome rearrangement events in parrots are ancient, and additionally, to an effect of body size on evolutionary rate that we found for mitochondrial but not nuclear sequences. Base composition analyses found that relative to other birds, parrots have unusually strong compositional asymmetry (AT- and GC-skew) in their coding sequences, especially at fourfold degenerate sites. Furthermore, we found higher AT skew in species with control region duplications. One potential cause for this compositional asymmetry is that parrots have unusually slow mtDNA replication. If this is the case, then any replicative advantage provided by having a second control region could result in selection for maintenance of both control regions once duplicated.
The Impact of International Internships and Short-Term Immersion Programs

For students in U.S. higher education institutions, global learning through study abroad has become a powerful force in student cultural competence. This chapter explores the impact of international internships and other short-term immersion experiences in further developing student learning, especially with respect to their understanding of the importance of global issues for their academic trajectories and future careers.
Improving the Navy's Passive Underwater Acoustic Monitoring of Marine Mammal Populations

Abstract : The long-term goals of this research effort are to improve the Navy s passive underwater acoustic monitoring of marine mammal populations. A major focus in this project is on further enhancing the ability to estimate environmentally-calibrated calling density (calls per unit area per unit time) obtained from raw detections of calls in underwater acoustic recordings. The efforts in this program also will support the Ph.D. research of a graduate student in marine bioacoustics and ocean acoustics at the Scripps Institution of Oceanography.
Randomized, Placebo‐Controlled Trial of the Cognitive Effect, Safety, and Tolerability of Oral Extended‐Release Oxybutynin in Cognitively Impaired Nursing Home Residents with Urge Urinary Incontinence

OBJECTIVES: Determine the cognitive effect, safety, and tolerability of oral extended-release oxybutynin in cognitively impaired older nursing home residents with urge urinary incontinence. DESIGN: Randomized, double-blinded, placebo-controlled trial. SETTING: Twelve skilled nursing homes. PARTICIPANTS: Fifty women aged 65 and older with urge incontinence and cognitive impairment. INTERVENTION: Four-week treatment with once-daily oral extended-release oxybutynin 5 mg or placebo. MEASUREMENTS: Withdrawal rates and delirium or change in cognition from baseline at 1, 3, 7, 14, 21, and 28 days after starting treatment using the Confusion Assessment Method (CAM), Mini-Mental State Examination (MMSE), and Severe Impairment Battery (SIB). The Brief Agitation Rating Scale, adverse events, falls incidence, and serum anticholinergic activity change with treatment were also assessed. RESULTS: Participants' mean age ±standard deviation was 88.6±6.2, and MMSE baseline score was 14.5±4.3. Ninety-six percent of subjects receiving oxybutynin (n=26) and 92% receiving placebo (n=24) completed treatment (P=.50). The differences in mean change in CAM score from baseline to all time points were equivalent between the oxybutynin and placebo groups. Delirium did not occur in either group. One participant receiving oxybutynin was withdrawn because of urinary retention, which resolved without treatment. Mild adverse events occurred in 38.5% of participants receiving oxybutynin and 37.5% receiving placebo (P=.94). CONCLUSION: Short-term treatment using oral extended-release oxybutynin 5 mg once daily was safe and well tolerated, with no delirium, in older female nursing home participants with mild to severe dementia. Future research should investigate different dosages and long-term treatment.
NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity

Reactive oxygen species are used by the immune system to eliminate infections; however, they may also serve as signaling intermediates to coordinate the efforts of the innate and adaptive immune systems. In this study, we show that by eliminating macrophage and T cell superoxide production through the NADPH oxidase (NOX), T cell polarization was altered. After stimulation with immobilized anti-CD3 and anti-CD28 or priming recall, T cells from NOX-deficient mice exhibited a skewed Th17 phenotype, whereas NOX-intact cells produced cytokines indicative of a Th1 response. These findings were corroborated in vivo by studying two different autoimmune diseases mediated by Th17 or Th1 pathogenic T cell responses. NOX-deficient NOD mice were Th17 prone with a concomitant susceptibility to experimental allergic encephalomyelitis and significant protection against type 1 diabetes. These data validate the role of superoxide in shaping Th responses and as a signaling intermediate to modulate Th17 and Th1 T cell responses.
Creating a Chinatown - Considerations for Christchurch

With the recent innovation and development within Christchurch following the earthquakes there have been suggestions of developing an ethnic precinct or 'Chinatown' within the city. This article explores the possiblity of this and its potential benefits .
A New Kind of Marketing: Creating Micro-Niches Using Resonance Marketing

Marketing has been dramatically changed by the Internet, the old rules do not apply. The Web allows companies to create products using micro-segmentation for target markets that are extremely small. Firms that want to be successful have to learn about resonance marketing. Resonance marketing used in conjunction with cause marketing and/or multicultural marketing can help a company find new market niches, charge premium prices. It can also be of great value to those interested in starting a small business.
An Ad Hoc SOR Method

Abstract An ad hoc method is presented for determining a sequence of successive overrelaxation factors (ω) that, although having no rigorous foundations at the moment, appears to produce a highly competitive iteration scheme for several classes of difference equations. A different ω is chosen for each difference equation.
A review of the literature evaluating the Defensive Driving Course

The Defensive Driving Course (DDC), like other post-licensure driver training programs, is intended to reduce the rate of motor vehicle crashes among those who take the course. A review of the literature revealed 14 controlled studies of the effects of DDC. About a third of these studies provided methodologically strong tests of DDC, but the remainder had design flaws that made their findings questionable or inadequate as tests of DDC. Only among the flawed tests were there large, positive effects of DDC. In the methodologically strong tests, DDC had no consistent effect on crashes but did decrease the frequency of traffic violations by about 10%. The failure of violation reductions to be translated into crash reductions may indicate that the violation reduction is an artifact of traffic record procedures or that the changes in driver behavior, if real, were insufficient to modify individual crash likelihoods. In either event, the best available evidence does not support the hypothesis that DDC decreases the likelihood of motor vehicle crashes.
Sublethal virus infection depresses cytochrome P-450 in an insect

Insect-specific cytoplasmic polyhedrosis virus infections, endemic in many species of insects, cause the gut tissue to assume on opaque, milky-white appearance through virus multiplication and formation of polyhedral protein inclusion bodies. Electron microscopy shows that the endoplasmic reticulum membrane is severely reduced and fragmented in infected midgut cells. Metabolism of foreign, lipophilic compounds, catalyzed by the membrane-bound cytochrome P-450, is significantly depressed, and resistance to insecticides disappears. In the absence of toxicants, most insects in this condition survive with sowewhat impaired fitness.
Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation.

On the basis of sequence homology and structural similarities, metabotropic glutamate receptors (mGluRs), extracellular Ca2+-sensing receptor, γ-aminobutyric acid type B receptor, and pheromone receptors are enlisted in a distinct family within the larger G protein-coupled receptor superfamily. When expressed in heterologous systems, group I mGluRs can activate dual signal transduction pathways, phosphoinositides turnover and cAMP production. To investigate the structural basis of these coupling properties, we introduced single amino acid substitutions within the second and third intracellular loops (i2 and i3) of mGluR1α. Wild-type and mutant receptors were expressed in human embryonic kidney 293 cells and analyzed for their capacity to stimulate both signaling cascades. Each domain appeared to be critical for the coupling to phospholipase C and adenylyl cyclase. Within i2, Thr695, Lys697, and Ser702 were found to be selectively involved in the interaction with Gq class α subunit(s), whereas mutation of Pro698 and the deletion Cys694-Thr695 affected only Gscoupling. Furthermore, the mutation K690A profoundly altered mGluR1α signaling properties and imparted to the receptor the ability to couple to the inhibitory cAMP pathway. Within i3, we uncovered two residues, Arg775 and Phe781, that are crucial for coupling to both pathways, since their substitution leads to receptor inactivation.
Detecting the Sybil Attack in Mobile Ad hoc Networks

Mobility is often a problem for providing security services in ad hoc networks. In this paper, we show that mobility can be used to enhance security. Specifically, we show that nodes that passively monitor traffic in the network can detect a Sybil attacker that uses a number of network identities simultaneously. We show through simulation that this detection can be done by a single node, or that multiple trusted nodes can join to improve the accuracy of detection. We then show that although the detection mechanism will falsely identify groups of nodes traveling together as a Sybil attacker, we can extend the protocol to monitor collisions at the MAC level to differentiate between a single attacker spoofing many addresses and a group of nodes traveling in close proximity.