cssi/SciSciGPT-SciSciNet huggingface dataset:
Punctures for theories of class $ {\mathcal{S}}_{\varGamma } $

With the aim of understanding compactifications of 6D superconformal field theories to four dimensions, we study punctures for theories of class $$ {\mathcal{S}}_{\varGamma } $$ . The class $$ {\mathcal{S}}_{\varGamma } $$ theories arise from M5-branes probing ℂ 2/Γ, an ADE singularity. The resulting 4D theories descend from compactification on Riemann surfaces decorated with punctures. We show that for class $$ {\mathcal{S}}_{\varGamma } $$ theories, a puncture is specified by singular boundary conditions for fields in the 5D quiver gauge theory obtained from compactification of the 6D theory on a cylinder geometry. We determine general boundary conditions and study in detail solutions with first order poles. This yields a generalization of the Nahm pole data present for 1/2 BPS punctures for theories of class $$ \mathcal{S} $$ . Focusing on specific algebraic structures, we show how the standard discussion of nilpotent orbits and its connection to representations of $$ \mathfrak{s}\mathfrak{u}(2) $$ generalizes in this broader context.
Prenatal Opioid Exposure and ADHD Childhood Symptoms: A Meta-Analysis.

To systematically investigate the association between prenatal opioid exposure (POE) and attention-deficit hyperactivity disorder (ADHD) symptoms in children 2–18 years old, studies were searched using PubMed, CINAHL, PsycINFO, and Web of Science from January of 1950 to October of 2019. Inclusion criteria were observational studies reporting ADHD symptoms of children with POE compared with non-exposed children or normative data. The study protocol was registered with PROSPERO: CRD42018115967. Two independent reviewers extracted data on hyperactivity/impulsivity, inattention symptoms, ADHD combined subscale symptoms, and sample characteristics. Of 223 articles screened, seven met the inclusion criteria. Data represent 319 children with POE and 1308 non-exposed children from 4.3 to 11.2 mean years from five countries. POE was positively associated with childhood hyperactivity/impulsivity (d = 1.40; 95% CI, 0.49–2.31; p = 0.003), inattention (d = 1.35; 95% CI, 0.69–2.01; p < 0.0001), and combined ADHD symptoms scores (d = 1.27; 95% CI = 0.79–1.75; p < 0.0001). POE was positively associated with ADHD combined symptom scores at preschool (d = 0.83, 95% CI, 0.57, 1.09; p < 0.0001) and school age (d = 1.45, 95% CI, 0.85 to 2.04; p < 0.0001). Results suggest increased risk of ADHD symptoms during school age. Future research is needed to clarify the relationship between biological, social, and environmental risk and ADHD symptoms for children who experienced POE.
Model Adaptation In Biomedical Image Reconstruction

Deep neural networks have been successfully applied to a wide variety of inverse problems arising in biomedical imaging. These networks are often trained using a forward model, which is not only used to generate the training data but is often incorporated directly into the network itself. However, these approaches lack robustness to misspecification of the forward model: if at test time the forward model varies (even slightly) from the one the network was trained on, the network performance can degrade substantially. Given a network trained to solve an initial image reconstruction problem with a known forward model, we propose novel retraining procedures that adapts the network to reconstruct measurements from a perturbed forward model. Our procedures do not require access to more labeled data (i.e., ground truth images), but only a relatively small collection of measurements under the perturbed forward model. We demonstrate this simple retraining procedure empirically achieves robustness to changes in the forward model for image reconstruction in magnetic resonance imaging from undersampled k-space measurements.
Cardiovascular Risk Factors in Younger Black Women: Results from the 10,000 Women Community Screening Project

Abstract Background Cardiovascular Disease (CVD) risk factors are prevalent in black women, but when these risk factors arise is not clear. We aimed to determine when obesity, hypertension, and hyperlipidemia appear in black women within a community screening program. Methods 945 black women who enrolled in the 10,000 Women community screening project in the metro Atlanta area were included (2015-2018). Socioeconomic, lifestyle, and traditional CVD risk factor information was patient-reported and measured. Characteristics of three cohorts stratified by age, 20-39 years old (yo), 40-59 yo, and ≥60 yo, were compared using pairwise analysis. Results All cohorts had class 1 obesity. Mean systolic blood pressure was higher in older cohorts [20-39 yo: 122 ± 15; 40-59 yo: 133 ± 19; ≥60 yo: 142 ± 20 mmHg; p Conclusion We report that CVD risk factors, like elevated blood pressure and obesity, are prevalent at young ages in black women, which could be due to lifestyle practices. Earlier initiation of CVD preventive care in black women could be beneficial; however, this needs to be studied further.
The Cytoskeleton During Early Development: Structural Transformation and Reorganization of RNA and Protein

Attention has been directed toward understanding the role of the cytoskeleton in the mediation of cellular events (reviewed in Schliwa 1986). Much of this research has focused on somatic cells and has provided the foundation for theories about cytoskeletal function. Although less is known about the cytoskeletons of oocytes, zygotes, and developing embryos, it is reasonable to expect that they share common functions with the somatic cell cytoskeleton as well as exhibit some unique, specialized functions. We first summarize the function of the cytoskeleton in somatic cells, then the role of the cytoskeleton in early development.
Multiple myeloma involving the mandible. Report of a case.

Abstract 1. 1. In the case reported here the patient achieved relief from right mandibular pain for the observable hospital period after tooth extractions. 2. 2. A simple diagnosis of caries-produced odontalgia was obscured by the presence of the osteolytic lesion surrounding the root apex of the severely carious lower right second molar. 3. 3. Apical root resorption of the lower right second molar was apparently due to encroachment of the coalescing osteolytic lesion which was observed chronologically by radiographic studies. 4. 4. The lytic tissue present in the apical portion of the lower right second molar socket had not proliferated occlusally before slow but apparently normal socket healing occurred. 5. 5. The potential mandibular fracture was avoided by judicious instrumentation. 6. 6. The patient was discharged from the hospital shortly after completion of dental treatment and died approximately 24 months after the diagnosis of multiple myeloma had been established. A singular cause for the “odontalgia” suffered by the patient has not been totally resolved within the scope of this case report. Certainly, the presence of both a large carious lesion and the osteolytic lesion of multiple myeloma would have contributed to the jaw pain.
CPW line-to-line coupling on glass and low resistivity silicon

This paper presents experimental results for line-to-line coupling between adjacent coplanar waveguide (CPW) transmission lines. The CPW lines are fabricated on glass and low resistivity CMOS grade Si substrates coated with a 20/spl mu/m cyclotene polymer. From the measurement results it is found that the coupling increases with frequency on low resistivity silicon substrate while the coupling on glass shows relatively constant peaks. A spacing of 600/spl mu/m between CPW lines is required to avoid parasitic coupling less than 30dB for frequencies up to 30GHz when fabricated on low resistivity silicon, while a spacing of 200/spl mu/m is required when fabricated on glass. The conductor width (W) and the slot width (S) for low resistivity silicon is 80/spl mu/m and 45/spl mu/m, and on the glass substrate W = 150/spl mu/m, S = 30/spl mu/m. Based on full-wave EM simulation results, it is argued that the primary coupling mechanism is through the interaction of higher-order modes.
Trying to Touch “A Touchy Case”: Discussion of a Clinical Case by Jack Drescher

Looking for a different perspective that might deepen this otherwise good psychoanalytic process, the author focuses on the remarkable family history of multiple losses that seem not to have been mourned by anyone, including the patient. Like his family, he formed a defensive armor to deaden his feelings and to avoid grief and fear of further loss. It is suggested that the difficult task for the analyst is fostering, and then analyzing, the transference-countertransference repetition of the vulnerable little boy and the emotionally unavailable, oedipal father.
Magnetic properties of nanoclusters embedded in HCP

Abstract The magnetic properties of 3 He nanoclusters in phase-separated solid 3 He – 4 He mixture were investigated for samples with pressures between 2.64 and 3.71 MPa and temperatures between 0.6 and 10 mK . From pulse NMR from 62 to 250 kHz , it was found that there are two components with different spin–spin relaxation times for the samples of pressure from 2.95 to 3.04 MPa . The component with longer T 2 ∗ showed large downward deviation from Curie law or decrease of magnetization at about 1.05 mK which was larger for lower field. The component with shorter T 2 ∗ showed ferromagnetic tendency. The solid-like fraction was obtained from the relative magnitudes of magnetization and it shows a sharp increase with pressure around 2.95 MPa .
A modification of the two-antenna method to determine the phase center location as well as the gain of a wideband antenna

A technique is presented for determining the amplitude center or phase center location of a wideband Vivaldi antenna at measurement distances of a few wavelengths. It is based on the well known two-antenna gain measurement technique but makes the antenna separation a variable. The phase center separation is shown to be proportional to the derivative of a transmission matrix loss parameter which is constant and independent of the antenna separation. A linear least squares fit to transmission loss parameters measured at several antenna separations is shown to yield the antenna gain and phase center location.
Preceramic Occupations in the Orinoco River Valley

Two sites in the Orinoco Valley containing preceramic from excavated contexts are described. Radiocarbon dating and stylistic comparisons indicate that the northern tropical lowlands were inhabited at the onset of the Holocene, suggesting a time depth of 9000 years before the present for tropical forest-savanna adaptations in northern South America.
Performability: a retrospective and some pointers to the future *

Abstract As computing and communication systems become physically and logically more complex, their evaluation calls for continued innovation with regard to measure definition, model construction/solution, and tool development. In particular, the performance of such systems is often degradable, i.e., internal or external faults can reduce the quality of a delivered service even though that service, according to its specification, remains proper (failure-free). The need to accommodate this property, using model-based evaluation methods, was the raison d'etre for the concept of performability. To set the stage for additional progress in its development, we present a retrospective of associated theory, techniques, and applications resulting from work in this area over the past decade and a half. Based on what has been learned, some pointers are made to future directions which might further enhance the effectiveness of these methods and broaden their scope of applicability.
Identifying Fungal Regulatory Motif Patterns Using SCOPE, an Ensemble Learning Method Motif Finder

We reported previously on the development of SCOPE, an ensemble learning method motif finder. In this study, SCOPE was used to examine motif patterns for gene sets regulated by transcription factors MBF and SBF in Saccharomyces cerevisiae. Gene sets individually regulated by MBF or SBF and gene sets that could be regulated by either MBF or SBF clustered separately. This clustering was dependent on the presence of recognition motifs, their position distribution upstream of the gene start and binding site differences. Highly similar sequences were also identified for homologs of MBF-regulated S. cerevisiae genes in 11 other fungal species. SCOPE consistently identified a core motif, CGCG, but the neighboring bases slightly varied in different species, as did position preferences. Results indicate that the presence of a motif, its position with respect to a gene start and its context are important factors in gene regulation.
Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids.

In situ hybridization was used to localize and quantify gene expression in rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissue. Collagenase, tissue inhibitor of metalloproteinases (TIMP), HLA–DR, and complement (C2 and C3) gene expression was studied in synovial tissue from 23 patients with RA, OA, or other inflammatory arthropathies. Gene expression was highly compartmentalized: Collagenase, TIMP, and C2 messenger RNA (mRNA) were localized primarily to the synovial lining layer; HLA–DR mRNA was prominent in the lining and in some sublining lymphoid aggregates; the C3 probe hybridized only to sublining lymphoid aggregates. Relative mRNA levels were quantified using computer-assisted image analysis. There was significantly more collagenase, C2, C3, and HLA–DR mRNA in RA compared with OA patients. However, TIMP mRNA levels were similar in RA and OA. Expression of collagenase, TIMP, C2, C3, and HLA–DR genes correlated with the degree of synovial inflammation. The effect of intraarticular corticosteroid injection on synovial tissue gene expression was studied using serial percutaneous synovial biopsy samples from the knees of 3 RA patients. Joints were biopsied, injected with triamcinolone, and rebiopsied 1–2 weeks later. Histologic inflammation scores were lower in posttreatment synovia. Collagenase and TIMP mRNA, although abundant in presteroid samples, were nearly undetectable in post-steroid tissues. HLA–DR mRNA levels also were significantly decreased. C2 and C3 hybridization significantly decreased in 2 of 3 patients and 1 of 3 patients, respectively. Hence, clinical response to intraarticular steroid therapy was accompanied by histologic improvement and decreased expression of genes that play a role in articular destruction. This study demonstrates the power of quantitative in situ hybridization as a tool for studying drug efficacy and mechanism.
Trisomy 21 associated with ovarian dysgerminoma

A 13-year-old G(0)P(0) white female with trisomy 21 presented with a complex pelvic mass. She underwent resection of the mass and complete staging for what was found to be a stage IIIC completely resected dysgerminoma. She was treated with three cycles of bleomycin, etoposide, and cisplatin chemotherapy and remains free of disease 1 year later. This association is presented as a rare case that may illustrate the relative increase in germ cell neoplasms in female patients with Down's syndrome. While the association of seminoma with Down's syndrome has been documented in a number of cases in males, the female counterpart of this tumor, dysgerminoma, in trisomy 21 has been reported quite infrequently. The potential for germ cell tumors in both male and female trisomy 21 is therefore illustrated.
Attitudes and action: the effects of behavioral intent and perceived effectiveness of acts.

Summary Based on the assumption that an individual's behavioral intentions mediate the relationship between his attitudes and behaviors, an attempt was made to obtain a direct assessment of (a) subjects' intentions with regard to a series of acts varying in behavioral thresholds and (b) the perceived instrumentality of these acts for achieving one's goals After the reliability of the Intentions Scale was established, it was combined multiplicatively with ratings of perceived effectiveness to form a combined Action Potential Index (AP) The index resulted in significantly greater predictive validity than a conventional attitude assessment instrument. A second study was undertaken to determine the consistency of the AP-index across issues. The high correlations obtained for the AP-index across three issues suggested the operation of an “activism” personality dimension
Judge me more by my future than by my past

Premature death rites have occurred before. Truman was prematurely declared the loser before he won the 1948 election. Mark Twain, said “Rumors of my death have been seriously exaggerated.” Huck Finn attended his own funeral. The 1969 New York Mets were deemed vanished prior to their miraculous comeback and World Series victory. Churchill changed political parties but continued to rebound. Phil Nieckro, the great knuckleball pitcher, was continually counted out but kept returning for another year. John Travolta’s career seemed moribund before he reemerged with the leading roles in Pulp Fiction and Phenomenon. Premature deaths occur not only in lifestyles, but in professions. In the field of human resources (HR), death rites have been proclaimed, eulogies written, and funerals prepared for the demise of the HR function. These eulogies are premature. While HR as we know it (with images of policy police, regulators, and administrative guardians) has passed, a new HR is emerging. If HR is to play the more significant role many advocate, then the future will have to be characterized by understanding and mastering nine challenges.
Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors

Background Several γ-secretase inhibitors (GSI) are in clinical trials for the treatment of Alzheimer's disease (AD). This enzyme mediates the proteolytic cleavage of amyloid precursor protein (APP) to generate amyloid β protein, Aβ, the pathogenic protein in AD. The γ-secretase also cleaves Notch to generate Notch Intracellular domain (NICD), the signaling molecule that is implicated in tumorigenesis.
Gradient-index eyepiece design

A study of gradient-index eyepieces was conducted. The general performance of homogeneous eyepieces having two and three elements was examined. Axial gradients were introduced into the eyepieces in an attempt to increase the half-fields of view to 25° and extend the eye reliefs to 12 mm. The homogeneous eyepieces examined were of the Huygenian, Ramsden, and Kellner configurations. These eyepieces were scaled to the specifications of f/3, 21.4-mm focal length, and magnifying power of 10×. These classic systems were optimized to produce two- and three-element homogeneous eyepieces to determine how homogeneous systems could perform with the extended eye relief and larger field of view. Axial gradient eyepieces having two and three elements were designed to the same specifications. The balance of third-order aberrations, color, and distortion was maintained or improved compared to the homogeneous systems.. The additional degrees of freedom associated with the gradient made it possible to extend the eye relief and increase the field of view of these eyepieces.
A theorem on flows in networks

The theorem to be proved in this note is a generalization of a well-known combinatorial theorem of P. Hall, [4].
Specialty care single and multi-period location–allocation models within the Veterans Health Administration

Abstract Optimal location of specialty care services within any healthcare network is increasingly important for balancing costs, access to care, and patient-centeredness. Typical long-range planning efforts attempt to address a myriad of quantitative and qualitative issues, including within-network access within reasonable travel distances, space capacity constraints, costs, politics, and community commitments. To help inform these decisions, single and multi-period mathematical integer programs were developed that minimize total procedure, travel, non-coverage, and start-up costs to increase network capacity subject to access constraints. These models have been used to help the Veterans Health Administration (VHA) explore relationships and tradeoffs between costs, coverage, service location, and capacity and to inform larger strategic planning discussions. Results indicate significant opportunity to simultaneously reduce total cost, reduce total travel distances, and increase within-network access, the latter being linked to better care continuity and outcomes. An application to planning short and long-term sleep apnea care across the VHA New England integrated network, for example, produced 10–15% improvements in each performance measure. As an example of further insight provided by these analyses, most optimal solutions increase the amount of outside-network care, contrary to current trends and policies to reduce external referrals.
Drotrecogin Alfa (Activated) Approved for Treatment of Severe Sepsis

Drotrecogin alfa (activated) is a recombinant form of human activated protein C that has been shown to reduce mortality in severely septic patients with a high risk of death. Given the complexity of the inclusion and exclusion criteria, the stability and unique duration of infusion, and the cost of treatment, therapy with this agent should be carefully considered to ensure its appropriate use.
The art of assessing multiattribute utility functions

Abstract Multiattribute utility theory is appropriate for developing preference models to address value trade-offs among multiple objectives and uncertainty in complex problems. The purpose of this paper is to illustrate by an example how one puts the theory into practice. The example chosen concerns energy policy. Specifically, an 11-attribute utility function over attributes including deaths, SO2 pollution, radioactive waste, health effects, and electrical energy generated is assessed. A dialogue indicating the procedure used, with comments on why various questions were asked, is presented in detail. The resulting utility function is being used to examine energy policies differing in terms of main fuel (fossil or nuclear) and degree of conservation.
Use of microearthquakes in the study of the mechanics of earthquake generation along the San Andreas fault in central California

Abstract A small, dense network of independently recording portable seismograph stations was used to delineate the slip surface associated with the 1966 Parkfield-Cholame earthquake by precise three dimensional mapping of the hypocenters of its aftershocks. The aftershocks were concentrated in a very narrow vertical zone beneath or immediately adjacent to the zone of surf ace fracturing that accompanied the main shock. Focal depths ranged from less than 1 km to a maximum of 15 km. The same type of portable network was used to study microearthquakes associated with an actively creeping section of the San Andreas fault south of Hollister during the summer of 1967. Microearthquake activity during the 6-week operation of this network was dominated by aftershocks of a magnitude-4 earthquake that occurred within the network near Bear Valley on July 23. Most of the aftershocks were concentrated in an equidimensional region about 2 1 2 km across that contained the hypocenter of the main shock. The zone of the concentrated aftershocks was centered near the middle of the rift zone at a depth of about 3 1 2 km . Hypocenters of other aftershocks outlined a 25 km long zone of activity beneath the actively creeping strand of the fault and extending from the surface to a depth of about 13 km. A continuing study of microearthquakes along the San Andreas, Hayward, and Calaveras faults between Hollister and San Francisco has been under way for about 2 years. The permanent telemetered network constructed for this purpose has grown from about 30 stations in early 1968 to about 45 stations in late 1969. Microearthquakes between Hollister and San Francisco are heavily concentrated in narrow, nearly vertical zones along sections of the Sargent, San Andreas, and Calaveras faults. Focal depths range from less than 1 km to about 14 km.
Consistency tests for key comparison data

Results of International Key Comparisons of National Measurement Standards provide the technical basis for the Mutual Recognition Arrangement (MRA) formulated by Le Comite International des Poids et Mesures (CIPM). With many key comparisons already completed and a number of new key comparison experiments currently under way, we now have a better understanding of the statistical issues that need to be addressed for successfully analysing data from key comparisons and making proper interpretations of the results. There is clearly a need for a systematic approach to statistical analyses of key comparison data that can be implemented routinely by all participating laboratories.The determination of a key comparison reference value (KCRV) and its associated uncertainty and the degrees of equivalence are the central tasks in the evaluation of key comparison data. A satisfactory definition of a KCRV, however, is based on the assumption that all laboratories are estimating the same unknown quantity of the common circulating artefact, that is, the results from the different laboratories are mutually consistent. In this paper, we compare a number of statistical procedures for testing the consistency assumption.
Environmental enrichment for zoo bears

The high incidence of stereotypic behaviors in zoo bears (van Keulen-Kromhout: International Zoo Yearbook 18:177–186, 1978) suggests that the environment of these animals lacks essential stimuli for guiding normal behavior. Three experiments investigated ways in which bear husbandry procedures can be altered to promote normal behavior. In experiments 1 and 2, honey-filled logs were given to a sloth (Melursus ursinus), American black (Ursus americanus), and brown bear (Ursus arctos) to determine 1) the role of food in stimulating investigatory behavior, 2) the rate of habituation to manipulable objects introduced into the exhibit, and 3) effects on locomotory behaviors. Results show specific and general habituation to the introduced objects that can be counteracted by refilling the logs with honey and by providing multiple logs in the exhibit. Investigatory activity directed toward honey-logs replaces pacing and walking in the sloth bear and is most effective in doing so when the log is novel. Experiment 3 examined the behavioral effects of feeding an American black bear in three different ways: 1) once daily in the den, 2) once daily with supplemental food from a mechanical feeder, and 3) once daily with food hidden in the exhibit in manipulatable objects. The latter method reduced stereotypic pacing from a median of 150 min/day to 20 min/day; the mechanical feeder method had no such effect. The results of a survey of 67 zoos concerning the diet and manner of feeding these three species of bears, as well as Asian black bears (Ursus thibetanus) are presented. Results are discussed with respect to the ways in which husbandry procedures can be improved to stimulate functional foraging and feeding behavior in confined bears.
Theoretical Aspects of Minority Carrier Extraction in Unipolar Barrier Infrared Detectors

We have examined, theoretically, minority carrier collection in unipolar barrier infrared photodetectors. In barrier infrared detectors, for example the nBn, the unipolar barrier should block only majority carriers and allow unimpeded flow of minority carriers. However, an imperfect barrier would also block minority carriers, resulting in higher than expected turn-on bias. Minority carrier blocking can be caused by barrier doping or unintended band offset between the barrier and the absorber. The distinct manner in which these two mechanisms affect device performance were investigated. We found that introduction of an appropriate amount of barrier doping can reduce depletion dark current without increasing turn-on bias. We examined the effects of band structure on conductivity effective masses when the n-type absorber was a type-II superlattice (T2SL). We showed that for a long-wavelength infrared InAs/GaSb T2SL the vertical conductivity hole effective mass can be much smaller than that predicted by the simple band-edge effect mass picture, implying that the vertical hole mobility estimated from the band-edge effective mass can be unduly pessimistic.
Trace metal complexation by the triscatecholate siderophore protochelin: structure and stability.

Although siderophores are generally viewed as biological iron uptake agents, recent evidence has shown that they may play significant roles in the biogeochemical cycling and biological uptake of other metals. One such siderophore that is produced by A. vinelandii is the triscatecholate protochelin. In this study, we probe the solution chemistry of protochelin and its complexes with environmentally relevant trace metals to better understand its effect on metal uptake and cycling. Protochelin exhibits low solubility below pH 7.5 and degrades gradually in solution. Electrochemical measurements of protochelin and metal–protochelin complexes reveal a ligand half-wave potential of 200 mV. The Fe(III)Proto3− complex exhibits a salicylate shift in coordination mode at circumneutral to acidic pH. Coordination of Mn(II) by protochelin above pH 8.0 promotes gradual air oxidation of the metal center to Mn(III), which accelerates at higher pH values. The Mn(III)Proto3− complex was found to have a stability constant of log β110 = 41.6. Structural parameters derived from spectroscopic measurements and quantum mechanical calculations provide insights into the stability of the Fe(III)Proto3−, Fe(III)H3Proto, and Mn(III)Proto3− complexes. Complexation of Co(II) by protochelin results in redox cycling of Co, accompanied by accelerated degradation of the ligand at all solution pH values. These results are discussed in terms of the role of catecholate siderophores in environmental trace metal cycling and intracellular metal release.
Transitional Phase of a Security Manager: A Closer Look into the Struggles and Difficulties Experienced during the Transition into Security Management

This research report tests employment transition for the modern day security manger. In this experiment 30 subjects were asked to complete a 14-question survey regarding their personal experiences that took place during the transitioning phase of previous employment into the field of security. The results of this study showed that security managers are well educated and progressive in their viewpoints of security as a business function, although hardships were experienced during their transition. Answers point to the understanding that a lack of training dominate the field of security management, and point to the necessity of security management as an academic focus.
MEASUREMENT OF MEAN PEAK BLOOD FLOW USING DUPLEX ULTRASOUND IN THE NEONATE

Duplex ultrasonography combines a range-gated Doppler flowmeter with real time 2-dimensional ultrasound imaging to yield measurements of blood velocity and cross-sectional area. Flow is calculated using the equation F = V * A where V = velocity and A = cross-sectional area. To evaluate the validity of this technique we obtained measurements in an in vitro model of pulsatile flow (1) and in the dog using the carotid and brachial arteries. Flow calculations of mean peak flow were compared to direct (volumetric) measurements (n = 50) of mean flow in the in vitro model and indirect (surgically-placed electromagnetic flowmeter) measurements (n = 40) of mean flow in the dog. The correlation was 0.90 with the in vitro model and 0.80 with the dog model. We then measured mean peak blood flow in the anterior cerebral artery of 13 neonates through the anterior fontanelle. Flow ranged from 0.87 to 10.39 cc/min (mean 3.88 cc/min). We conclude that noninvasive measurement of blood flow with duplex ultrasonography is comparable to other established direct, invasive methods, and may be useful in the evaluation of the intracranial circulation in the neonate. 1. Miles, R.: Transmission of vibration from simulated arterial stenosis. Masters Thesis, Iowa State University, 1976.
Best Practices for Dealing with Price Volatility in Commercial Construction

In the commercial construction industry, the problem of price volatility as it pertains to materials and labor is a consistent problem. The changing instability of market conditions presents a challenge for construction companies to accurately estimate and complete projects within budget. This volatility can lead to higher costs and more risk to suppliers, contractors, and owners which can cause financial distress for all parties involved in the construction process. Volatility in construction will continue to be a risk that participants in the construction industry will face. Price volatility can be economically dangerous when price changes affect the assumptions on which the contract is based. In an effort to identify the best practices being used by parties in the commercial construction industry for dealing with the risk of price fluctuation, panel members consisting of construction industry experts in the state of Utah were given rounds of questionnaires. This research report summarizes the responses...
Isotopic differences in human growth hormone preparations

The 13C/12C isotope ratios have been measured for human pituitary growth hormone and three commercial growth hormone products in an attempt to differentiate endogenous versus exogenous origin. This might be a strategy to detect doping, as has recently been recognized for testosterone. While all preparations are statistically different from each other, we find that only Humatrope from Lilly has a carbon isotope ratio that is markedly different from those of human growth hormone or Genentech's Nutropin and Protropin. The low renal clearance of growth hormone reduces the applicability of this concept.
Confidence intervals for the odds ratio in case-control studies: a calculator program for Cornfield's method.

Abstract A Hewlett-Packard 67 calculator program is given to compute confidence intervals for odds ratios in case-control studies, using the method of Cornfield and an algorithm of Fleiss. Recent work by Brown has shown Cornfield's method to be superior to other approximate methods of odds ratio confidence interval computation and to agree closely with Fisher's exact method. Although a calculator program for the exact method is available in the literature, the convergence times are frequently in excess of 30 min. The program for Cornfield's method given below typically yields upper and lower confidence limits in
Pater meus agricola est: the early years of Alexander Agricola

The circumstances of Alexander Agricola's birth and early years, as revealed by newly discovered documents in Ghent, were not especially happy. He and his brother Jan (who was almost certainly a musician as well) were the illegitimate children of Lijsbette Naps, an independent businesswoman in her forties who, according to all indications, had been taken advantage of by their natural father, Heinric Ackerman. The latter emerges as an unreliable and unscrupulous individual, an expert in what we now call creative accounting, who apparently sought to make his fortune by marrying or handling the affairs of wealthy women. In 1444 he seems have set his sights on Lijsbette Naps, with whom he had traded on behalf of another woman early that year. Lijsbette was wealthy, independent, and by all accounts not a person who could easily be duped—least of all by Heinric, in whom she clearly had little trust. Yet she was also vulnerable: unmarried, without family or other social networks in Ghent, and, as a non-citizen, not entitled to a range of civic privileges and legal protections. Given what the documents reveal about Heinric's previous dealings, it is not hard to guess what might have happened next. This essay presents the most likely scenario in light of the available evidence, and discusses the consequences and implications for the composer's youth and upbringing in Ghent during the 1450s and early 1460s. The circumstances of his birth, as it turns out, lend considerable irony to the scriptural passage which Agricola selected as the title for one of his musical settings: ‘I am the true vine, and my Father is the husbandman’ (pater meus agricola est; John 15:1). By the standards of his own time, Alexander was neither a ‘true’ vine, nor had his father proved himself a caring husbandman. The musical fruits he bore as a composer are to be credited in large part to Lijsbette, who chose to raise her sons as a single mother while running a profitable business and maintaining her social and economic independence.
Comment on "A simple tool for neuroimaging data sharing".

In our recent paper “A simple tool for neuroimaging data sharing,” we introduced a system for sharing DICOM data. Addressing anonymization, we mentioned DICOM Supplement 551, the National Cancer Institute deidentification profile, and the default deidentification profile in XNAT's DICOM Browser and noted the disagreement in these various anonymization profiles. While a careful analysis of anonymization (especially as applied to DICOM) was not in the scope of this work, we could also have mentioned further work from the DICOM Standards Committee, specifically Supplement 1422 (Clinical Trial De-identification Profiles) and Annex E (Attribute Confidentiality Profiles) of PS3.153 (Security and System Management Profiles), which provide well thought-out and detailed analyses and recommendations for anonymization of DICOM data by dedicated working groups. Also, in our observation of the current state of DICOM anonymization within the neuroimaging research community, we stated that no consensus could be found. Certainly most solutions in the neuroimaging research community do not follow the DICOM standard, preferring instead to design their own schemes that satisfy different levels of anonymization needed given each specific Institutional Review Board's (IRB) requirements and the nature of the specific data; the result is a lack of consensus in this particular community. This is an unfortunate reality and should not be construed to reflect negatively on the effort and the outcomes of the DICOM working groups, which are consensus solutions from the broader imaging community. Indeed, there are several tools that support the DICOM standards out of the box, among these dicom-anon4 (supporting PS3.15, Annex E), DICOM Anonymizer5 (PS3.15, Annex E), the CTP DICOM Anonymizer6 (Supplement 142), and gdcmanon7 (PS3.15, Annex E and Supplement 142). However, these tools have been developed for radiological or more general biomedical research applications and the authors have not seen them adopted by the neuroimaging community. Tools such as DicomBrowser8, part of the XNAT environment more familiar to neuroimagers, tend to focus on flexible anonymization, and configuration files supporting PS3.15, Annex E are available but must be downloaded separately. By integrating all of these considerations regarding anonymization profiles, we hope that the neuroimaging research community will also begin to converge on standardization of this important aspect of data sharing.
Electron counting and valence instability in CeT3Bn systems: L3 studies

Abstract Ce-L 3 -valence estimates are presented for the Ce(T 1 −x T′ x ) 3 B n compound series with T and T′ being the 4d elements Ag, Pd, Rh and Ru and with n = 0, 1 and 2. The coupling of the Ce-valence instability to the band electron count and the effective B contribution to the electron count are discussed.
Is Cass's Model of Homosexual Identity Formation Relevant to Today's Society?

Cass's Homosexual Identity Formation Model (1979) is one of the most well-known and well-referenced models of identity development for gay males and lesbians. This article provides a review of Cass's six steps of the model, as well as research support for and critiques of the model. As the model was developed more than 30 years ago, the applicability of the model for today's youth is explored and implications for practitioners are discussed.
Benefit of intracytoplasmic sperm injection in patients with a high incidence of triploidy in a prior in vitro fertilization cycle

Objective To test the hypothesis that intracytoplasmic sperm injection (ICSI) overcomes a high incidence of tripronucleate zygotes resulting from standard insemination in a previous cycle. Design A retrospective analysis of matched-pair cycles. Setting Assisted reproductive technologies (ART) program of Brigham and Women's Hospital. Patient(s) Ninety-five patients with a ≥20% incidence of tripronucleate zygotes in an IVF cycle with use of ICSI in a subsequent attempt. Intervention(s) Cycles with either standard insemination or ICSI. Main Outcome Measure(s) Incidence of diploid (2pn) and triploid (3pn) zygotes and number and quality of embryos obtained. Result(s) Patient age, ampules of gonadotropin used, peak E 2 , number of follicles at hCG trigger, and total number of oocytes were all significantly higher in the ICSI cycles, but the number of mature oocytes did not differ. After ICSI, the percentage of 2pn was higher (65.0% vs. 34.1%) and the percentage of 3pn was lower (5.0% vs. 33.9%) than after IVF, and more diploid embryos were obtained with ICSI (5.5 ± 3.7 vs. 3.4 ± 2.2 [mean ± SD]). There was no difference in embryo quality between the two groups. Conclusion(s) ICSI appears beneficial in women with a high 3pn occurrence from IVF because it increases the number of diploid zygotes without affecting embryo quality.
A semi-automatic method for the production of primary cell suspensions

A method is described for the production of primary chick embryo cell suspensions that allows the processing of from 200 to several thousand embryos daily at a significantly lower cost than with other methods. Special apparatus enables high yields of cells, free of microbial contamination to be produced under controlled conditions with the minimum of supervision.
Thyroid disease and other endocrine disorders in pregnancy

Endocrine disorders are encountered frequently during pregnancy and the postpartum period. Most of these conditions are treatable and may affect mother and fetus adversely if they are not evaluated and managed appropriately. This article summarizes maternal endocrine adaptation to pregnancy and outlines common problems and their treatment. Hypothalamus and pituitary Hypothalamic releasing and inhibitory hormones regulate anterior pituitary function. These substances are produced in hypothalamic nuclei and reach the pituitary by way of a portal circulation. Thus, thyrotropin-releasing hormone (TRH) releases thyrotropin (TSH) and prolactin; growth hormone–releasing hormone releases growth hormone (GH), corticotropin-releasing hormone (CRH) releases corticotropin (ACTH), and gonadotropin-releasing hormone releases the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Normally, prolactin is under inhibitory control by way of the hypothalmic neurotransmitter, dopamine. The posterior pituitary is a storage site for oxytoxin and vasopressin, which are produced by the paraventricular nuclei. Osmoreceptors in the hypothalamus increase vasopressin release when plasma osmolality increases. Oxytocin is involved in parturition and suckling; maternal concentrations increase during gestation. Nipple stimulation promotes its release which leads to stimulation of myoepithelial cells in the breasts and milk letdown. Physiologic changes during pregnancy [1–3] are summarized in Box 1. The fetal pituitary and hypothalamus are functional midgestation.
Helical computed tomography of urinary tract stones: Accuracy and diagnostic value of stone size and density measurements

This study was carried out to determine the accuracy and diagnostic utility of ureteral stone size and density measurements at helical computed tomography (CT). Sixteen calciumcontaining and eight non-calciumcontaining ureteral stones of varying size and composition were examined in vitro with helical CT. Scans were obtained with 10-,5-,3-, and 1-mm collimation. Stone size was determined with CT calipers at each collimation thickness. Stone density was determined by using the maximum value obtained at pixelgram analysis, measured in Hounsfield units. Stone size measured with CT cursors closely matched actual stone size with 10-, 5-, 3-,and 1-mm collimation. Pixelgram density measurements steadily increased as slice thickness decreased. There was better separation of calciumcontaining from non-calcium-containing stones with thinner slices. CT stone size measurement does not vary significantly with slice thickness. CT stone density measurement in Hounsfield units does vary with slice thickness; the highest density numbers were recorded with the thinnest slice thicknesses. Density measurements did not reliably separate calciumcontaining from non-calcium-containing stones, but the amount of density overlap between the two stone types was diminished on the thinnest slices.
Violence and the Effects of Trauma on American Indian and Alaska Native Populations

Violence and the resulting trauma has had a major impact on American Indian/Alaska Native (AI/AN) children and their families, creating hardships that have been very difficult to address or overcome. This article provides a brief description of the cultures and shared beliefs of the indigenous people. A review of the recent published literature on poverty and historical trauma, including a discussion on oppression and hegemony, is presented. Additionally, recent research on violence and the resulting trauma, suicide, domestic violence, and post-traumatic stress disorder is described. A brief description of select cultural adaptations of evidence-based treatments is also provided.
Abstract A241: Targeting FGFR4 for rhabdomyosarcoma therapy.

Rhabdomyosarcoma (RMS) is a soft tissue sarcoma in children. Despite advances in modern therapy, metastatic patients with this disease have a very poor clinical prognosis. FGFR4 is a tyrosine kinase receptor which plays a role in cell division, regulating cell growth and maturation. FGFR4 also involves in myogenesis and is a direct downstream target of PAX3-FOXO1A found in the majority of alveolar RMS subtype, and suggests its oncogenic role in RMS. Our and other9s studies have shown that this gene is activated by amplification, over-expression and/or by mutation. Our previous data showed that activated FGFR4 promotes RMS tumor progression and inhibiting FGFR4 suppresses RMS tumor growth and metastasis. Ponatinib (Ariad, Cambridge, MA) is a multiple tyrosine kinase inhibitor that potently inhibits FGFR4 and is currently undergoing a pivotal phase 2 trial in adults with CML. Using a BaF3 TEL-FGFR4 model system, ponatinib was found to inhibit FGFR4 TK domain autophoshorylation and resulted in cell death. Five RMS cell lines that we have tested were all sensitive to ponatinib and the sensitivity was proportion to expression level of FGFR4. When treated with ponatinib, RMS cell line harboring the FGFR4 mutations K535 or E550, discovered by our group to be commonly mutated, were more sensitive to ponatinib compared to wild type as demonstrated by increase in active caspase 3/5 and in sub G1 population. Western blot confirmed that ponatinib inhibited autophosphorylation of FGFR4 K535 and E550 in a dose dependent manner. Furthermore, our pilot study also showed that the growth of subcutaneously injected RMS cells with the FGFR4 K535 mutants were suppressed after treating with ponatinib. Therefore our data suggest that ponatinib may be an effective therapy for patients with RMS and a clinical trial is warranted. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr A241.