cssi/SciSciGPT-SciSciNet huggingface dataset:
Genetic parameter estimates of growth curve and reproduction traits in Japanese quail

The goal of selection studies in broilers is to obtain genetically superior chicks in terms of major economic traits, which are mainly growth rate, meat yield, and feed conversion ratio. Multiple selection schedules for growth and reproduction are used in selection programs within commercial broiler dam lines. Modern genetic improvement methods have not been applied in experimental quail lines. The current research was conducted to estimate heritabilities and genetic correlations for growth and reproduction traits in a Japanese quail flock. The Gompertz equation was used to determine growth curve parameters. The Gibbs sampling under a multi-trait animal model was applied to estimate the heritabilities and genetic correlations for these traits. A total of 948 quail were used with complete pedigree information to estimate the genetic parameters. Heritability estimates of BW, absolute and relative growth rates at 5 wk of age (AGR and RGR), β0 and β2 parameters, and age at point of inflection (IPT) of Gompertz growth curve, total egg number (EN) from the day of first lay to 24 wk of age were moderate to high, with values ranging from 0.25 to 0.40. A low heritability (0.07) for fertility (FR) and a strong genetic correlation (0.83) between FR and EN were estimated in our study. Body weight exhibited negative genetic correlation with EN, FR, RGR, and IPT. This genetic antagonism among the mentioned traits may be overcome using modern poultry breeding methods such as selection using multi-trait best linear unbiased prediction and crossbreeding.
The National Wilms Tumor Study: a 40 year perspective

The National Wilms Tumor Study (NWTS) was the first pediatric intergroup clinical research unit in North America. It was thus able to collect data concerning children with malignant kidney tumors from each of the then-extant childhood cancer cooperative study groups. Enough patients—about 350 per year—could thus be gathered to study the nature and clinical characteristics of the various kidney malignant tumors of childhood. It also enabled randomized trials of comparative treatment regimens, patients stratified following stipulated risk criteria. The result has been a steadily increasing two-year survival rate to the 90% level while at the same time modulating the intensity of therapy according to well-defined needs. For example, routine post-operative radiation therapy, damaging to normal as well as neoplastic tissues, has been largely eliminated. The proportion of patients given doxorubicin, a cardiotoxic drug, also has been curtailed. These two therapies are now restricted to the 30% of patients who have more advanced or more aggressive disease. All this has been driven to meet the challenge inherent in the motto of pediatric oncology: “Cure is not enough”; that is, the cured child of to-day must not become the chronically ill adult of tomorrow, suffering from the delayed complications secondary to unnecessary, toxic therapies.
Experiments on the Flow Around a Sphere at High Reynolds Numbers

Fluid flow around sphere at high Reynolds number by measuring pressure distribution, considering boundary layer separation, tunnel blockage, etc
Cytoskeletal Regulation of TRPC Channels in the Cardiorenal System

Transient receptor potential canonical (TRPC) channels have been implicated in several aspects of cardiorenal physiology including regulation of blood pressure, vasoreactivity, vascular remodeling, and glomerular filtration. Gain and loss of function studies also support the role of TRPC channels in adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses TRP channels in the cardiovascular and glomerular filtration systems and their role in disease pathogenesis. We describe the regulation of gating of TRPC channels in the cardiorenal system as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of TRP channels in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure.
Effect of BioGlue® on the Incidence of Pancreatic Fistula Following Pancreas Resection

Despite numerous modifications of surgical technique, pancreatic fistula remains a serious problem and occurs in about 10% of patients following pancreas resection. BioGlue is a new sealant that creates a flexible mechanical seal within minutes independent of the body’s clotting mechanism. Application of BioGlue sealant will reduce the incidence of pancreatic fistula following pancreas resection. A retrospective cohort study was performed with 64 patients undergoing pancreas resection. BioGlue sealant was applied to the pancreatic anastomosis (Whipple) or resection margin (distal pancreatectomy) in 32 cases. Factors that could affect the rate of postoperative pancreatic fistula were recorded. Pancreatic fistula was defined as greater than 50 ml of drain output with an amylase content greater than three times normal serum value after postoperative day 10. To improve the sensitivity of our study, we also examined pancreatic fistula with a strict definition of any drain output on or after postoperative day 3 with a high amylase content and graded the fistulas in terms of clinical severity. Grade A leaks were defined as subclinical. Grade B leaks required some response such as making the patient nil per os, parenteral nutrition, octreotide, antibiotics, or a prolonged hospital stay. Grade C leaks were defined as serious and life threatening. They were associated with hemorrhage, sepsis, resulted in deterioration of other organ systems, and mandated intensive care. Comparisons between the two groups were made using the chi-square test or Fisher’s exact test for categorical variables and by the Wilcoxon rank-sum test for continuous variables. P values of 0.05 or less were deemed statistically significant. There were no differences between the patients who received BioGlue and the control cohort in terms of comorbid conditions, tumor location, texture of the pancreas, size of the pancreatic duct, or surgical technique. By the common definition, pancreatic fistula occurred in 6% (control) vs. 22% (BioGlue). By the strict definition, a fistula occurred in 41% (control) vs. 60% (BioGlue). In the control group, ten were subclinical (grade A) and two were clinically apparent leaks (grade B). In the BioGlue group, seven were subclinical (grade A), five were clinically apparent (grade B), and three were severe (grade C). There were no statistically significant differences in the incidence or severity grades of postoperative pancreatic fistulas between the two groups. Application of BioGlue sealant probably does not reduce the incidence of pancreatic fistula following pancreas resection.
N-(4-hydroxyphenyl) retinamide induces cell cycle specific growth inhibition in PC3 cells

The synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) has been demonstrated to inhibit the development of primary and metastatic neoplasms in several animal models. In order to investigate the effect of 4-HPR on human prostate adenocarcinoma, we designed a series of in vitro experiments with the PC3 cell line to evaluate effects on proliferation, cell cycle kinetics, and c-myc mRNA expression. 4-HPR demonstrated cytoxicity only at the supraphysiologic concentration of 10.0 μM. However, asynchronously growing cells exposed to 1 μM 4-HPR demonstrated a 51% reduction in proliferation rate, associated with an accumulation of cells in the G0/G1 phase of the cell cycle. PC3 cells synchronized with serum deprivation or aphidicoline exhibited significant decreases in DNA synthesis when treated with 1 μM 4-HPR. Additionally, these cells were found to accumulate in G0/G1 and S phase. Northern blots indicated a significant decrease in c-myc mRNA expression in asynchronously growing cells with continuous administration of 1 μM 4-HPR for 6 days. These data suggest that 4-HPR can inhibit growth of PC3 cells as a consequence of a block in cell cycle transition from G1 to S phase at a concentration of 1 μM, and that this inhibition is associated with a suppression of c-myc gene expression. © 1994 Wiley-Liss, Inc.
Design, Synthesis, Linear, and Nonlinear Optical Properties of Conjugated (Porphinato)zinc(II)-Based Donor−Acceptor Chromophores Featuring Nitrothiophenyl and Nitrooligothiophenyl Electron-Accepting Moieties

An extensive series of conjugated (porphinato)zinc(II)-based chromophores featuring nitrothiophenyl and nitrooligothiophenyl electron-accepting moieties has been synthesized using metal-catalyzed cross-coupling reactions involving [5-bromo-15-triisopropylsilylethynyl-10,20-diarylporphinato]zinc(II) and an unusual electron-rich Suzuki-porphyrin synthon, [5-(4-dimethylaminophenylethynyl)-15-(4‘,4‘,5‘,5‘-tetramethyl[1‘,3‘,2‘]dioxaborolan-2‘-yl)-10,20-diarylporphinato]zinc(II), with appropriately functionalized aryl and thienyl precursors. These donor−acceptor chromophores feature thiophenyl, [2,2‘]bithiophenyl, and [2,2‘;5‘,2‘ ‘]terthiophenyl units terminated with a 5-nitro group; one series of structures features these acceptor moieties appended directly to the porphyrin macrocycle meso-carbon position, while a second set utilizes an intervening meso-ethynyl moiety to modify porphyrin-to-thiophene conjugation. The dynamic hyperpolarizability of these compounds was determined from hyper-Rayleigh light scatte...
Mixed-Layer Kaolinite—Montmorillonite from the Yucatan Peninsula, Mexico

Clay beds 1–2 m thick and interbedded with marine limestones probably of early Eocene age are composed of nearly pure mixed-layer kaolinite-montmorillonite. Particle size studies, electron micrographs, X-ray diffraction studies, chemical analyses, cation exchange experiments, DTA, and TGA indicate that clays from three different localities contain roughly equal proportions of randomly interlayered kaolinite and montmorillonite layers. The montmorillonite structural formulas average K0·2Na0·2Ca0·2Mg0·2(Al2·5Fe 1·0 3+ Mg0·5)(Al0·75Si7.25)O20+(OH)4−, with a deficiency of structural (OH) in either the montmorillonite or kaolinite layers. Nonexchangeable K+ indicates that a few layers are mica-like. Crystals are mostly round plates 1/10 to 1/20 µ across. The feature most diagnostic of the mixed-layer character is an X-ray reflection near 8 A after heating at 300°C. The clays are inferred to have developed by weathering of volcanic ash and subsequent erosion and deposition in protected nearshore basins.
Heat transfer in micro region of a rotating miniature heat pipe

A theoretical model is established that describes the evaporating film flow in a rotating miniature heat pipe with an axial triangular grooved internal surface. The theory of thin liquid film vaporization heat transfer is used to predict the evaporation heat transfer in the micro region. The effects of disjoining pressure, surface tension and centrifugal force on the flow are discussed. Results show that the influence of centrifugal force on the liquid film flow and evaporation heat transfer in the micro region is not significant. The influence of superheat on the apparent contact angle and evaporation heat transfer coefficient in the micro region is shown.
Nonparametric iterative estimation of multivariate binary density

Abstract In this paper, an iterative estimate of the multivariate density is proposed when the variables are binary in nature. Some properties of this estimate are also discussed. Finally, applications of this estimate are discussed in the areas of pattern recognition and reliability.
Thrombin-induced phosphorylation of the myristoylated alanine-rich C kinase substrate (MARCKS) protein in bovine pulmonary artery endothelial cells.

Myristoylated alanine-rich C kinase substrate (MARCKS) is a prominent protein kinase C (PKC) substrate that is targeted to the plasma membrane by an amino-terminal myristoyl group. In its nonphosphorylated form, MARCKS cross-links F-actin and binds calmodulin (CaM) reciprocally. However, upon phosphorylation by PKC, MARCKS releases the actin or CaM. MARCKS may therefore act as a CaM sink in resting cells and regulate CaM availability during cell activation. We have demonstrated previously that thrombin-induced myosin light chain (MLC) phosphorylation and increased monolayer permeability in bovine pulmonary artery endothelial cells (BPAEC) require both PKC- and CaM-dependent pathways. We therefore decided to investigate the phosphorylation of MARCKS in BPAEC to ascertain whether this occurs in a temporally relevant manner to participate in the thrombin-induced events. MARCKS is phosphorylated in response to thrombin with a time course similar to that seen with MLC. As expected, MARCKS is also phosphorylated by phorbol 12-myristate 13 acetate (PMA), a PKC activator, but with a slower onset and more prolonged duration. Bradykinin also enhances MARCKS phosphorylation in BPAEC, but histamine does not. MARCKS is distributed evenly between the membrane and cytosol in BPAEC, and neither thrombin nor PMA caused significant translocation of the protein. Specific PKC inhibitors attenuated MARCKS phosphorylation by either thrombin or PMA. Since thrombin-induced MLC phosphorylation is also attenuated by these inhibitors, MARCKS may be involved in MLC kinase activation and subsequent BPAEC contraction. W7, a CaM antagonist, enhances the phosphorylation of MARCKS. This was expected since CaM binding to MARCKS has been shown to decrease MARCKS phosphorylation by PKC. On the other hand, tyrosine kinase inhibitors, genistein and tyrphostin, attenuate MARCKS phosphorylation but have no effect on MLC phosphorylation, suggesting that MARCKS may be phosphorylated by kinases other than PKC. Phosphorylation of MARCKS outside the PKC phosphorylation domain would not be expected to induce the release of CaM. These data provide support for the hypothesis that MARCKS may serve as a regulator of CaM availability in BPAEC. © 1996 Wiley-Liss, Inc.
Wildfire Consumption and Interannual Impacts by Land Cover in Alaskan Boreal Forest

Boreal forest fires are an important source of terrestrial carbon emissions, particularly during years of widespread wildfires. Most carbon emission models parameterize wildfire impacts and carbon flux to area burned by fires, therein making the assumption that fires consume a spatiotemporally homogeneous landscape composed of predominantly spruce forests and peat bogs with deep duff layers. While recent efforts have demonstrated that boreal forest fires heterogeneously consume aboveground vegetation, little remains known about the vegetation consumed during such fires. We examined climate, land cover, area burned, and fire impacts for large fires (2002 to 2009) across the Alaskan boreal landscape to address the validity of assumptions made by carbon emissions models for boreal fires. Results indicated that while coniferous vegetation, particularly spruce forests and spruce bogs, comprised the majority of the area burned in all years, shrub land cover comprised a substantial proportion (up to 35 %) of the area burned during warmer years of the study period. Interannual climate variability significantly influenced both the proportion of vegetation classes burned and the distribution of fire impacts across years and vegetation classes. We found that surface fuel modifications were sensitive to both the vegetation type that burned and climatic conditions. Area burned is an inadequate input metric for increasingly refined carbon emissions models, and consideration of heterogeneous fire impacts may improve carbon emissions modeling.
An on-line square rooting algorithm

An on-line algorithm for computing square roots in a radix 2, normalized floating-point number system with the redundant digit set {-1, 0, 1} is described. The algorithm has on-line delay of one and it is amenable for modular implementation. A systematic approach, used in deriving this algorithm, is presented in detail.
Hypoxia induced changes in expression of proteins involved in iron uptake and storage in cultured lens epithelial cells

Hypoxia inducible factor (HIF) regulates expression of over 60 genes by binding to hypoxia response elements (HRE) located upstream of the transcriptional start sites. Many genes encoding proteins involved in iron transport and homeostasis are regulated by HIF. Expression of iron handling proteins can also be translationally regulated by binding of iron regulatory protein (IRP) to iron responsive elements (IREs) on the mRNA of ferritin chains and transferrin receptor (TfR). Lens epithelial cells (LEC) function in a low oxygen environment. This increases the risk of iron catalyzed formation of reactive oxygen species (ROS) and oxidative cell damage. We examined changes in expression of ferritin (iron storage protein) and Tf/TfR1 (iron uptake proteins) in LEC cultured under hypoxic conditions. Ferritin consists of 24 subunits of two types, heavy (H-chain) and light (L-chain) assembled in a cell specific ratio. Real-time PCR showed that 24 h exposure to hypoxia lowered transcription of both ferritin chains by over 50% when compared with normoxic LEC. However it increased the level of ferritin chain proteins (20% average). We previously found that 6 h exposure of LEC to hypoxia increased the concentration of cytosolic iron which would stimulate translation of ferritin chains. This elevated ferritin concentration increased the iron storage capacity of LEC. Hypoxic LEC labeled with 59FeTf incorporated 70% more iron into ferritin after 6 h as compared to normoxic LEC. Exposure of LEC to hypoxia for 24 h reduced the concentration of TfR1 in cell lysates. As a result, hypoxic LEC internalized less Tf at this later time point. Incorporation of 59Fe into ferritin of hypoxic LEC after 24 h did not differ from that of normoxic LEC due to lower 59FeTf uptake. This study showed that hypoxia acutely increased iron storage capacity and lowered iron uptake due to changes in expression of iron handling proteins. These changes may better protect LEC against oxidative stress by limiting iron-catalyzed ROS formation in the low oxygen environment in which the lens resides.
A representation of Jacchia's thermospheric models in spherical harmonic functions

The Jacchia models are represented in terms of spherical harmonic functions. This representation has the advantage of ease of comparison with other global theoretical and empirical models that use this mathematical form. Furthermore, it is analytic, continuous, and has continuous derivatives all over the globe. The representation of the exospheric temperatures shows clearly the amplitudes of the various periodic terms and uses relatively few constants. An example of a similar representation for the total mass density at a particular height and level of solar activity is given as well.
Smart electrochemical biosensors: From advanced materials to ultrasensitive devices

Abstract The specificity, simplicity, and inherent miniaturization afforded by advances in modern electronics have allowed electrochemical sensors to rival the most advanced optical protocols. One major obstacle in implementing electrochemistry for studying biomolecular reaction is its inadequate sensitivity. Recent reports however showed unprecedented sensitivities for biomolecular recognition using enhanced electronic amplification provided by new classes of electrode materials (e.g. carbon nanotubes, metal nanoparticles, and quantum dots). Biosensor technology is one area where recent advances in nanomaterials are pushing the technological limits of electrochemical sensitivities, thus allowing for the development of new sensor chemistries and devices. This work focuses on our recent work, based on metal-enhanced electrochemical detection, and those of others in combining advanced nanomaterials with electrochemistry for the development of smart sensors for proteins, nucleic acids, drugs and cancer cells.
Cortisol metabolite binder. I. Identity with the dimethylaminoazobenzene binding protein of liver cytosol.

Abstract Of the four macromolecules in liver cytosol that bind anionic metabolites of cortisol, the basic protein, designated “cortisol metabolite binder I”, is identical to the protein that binds dimethylaminoazobenzene. This conclusion is based on double label experiments with the 14C-labeled azo dye and tritiated cortisol. Correspondence of the two labels persists through fractionation steps leading to homogeneity: molecular sieve filtration of liver cytosol, column chromatography on DEAE Sephadex A-50, chromatography on cellulose-P columns and gel filtration on Sephadex G-75. In addition, there is convincing agreement in the reported values of molecular weight, sedimentation coefficient, isoelectric pH and amino acid composition. This demonstration provides, for the first time, evidence that carcinogens and corticosteroids have an identical site of action at the molecular level.
Tumor cell contamination of peripheral blood stem cell transplants and bone marrow in high-risk breast cancer patients

Twenty-one high-risk patients with primary stage II/III breast cancer were treated with high-dose chemotherapy comprising etoposide, ifosfamide, carboplatin and epirubicin (VIC-E). Tumor cells of epithelial origin were analyzed using the monoclonal antibodies CK2 (IgG1) and A45-B/B3 (IgG1) against cytokeratin (CK) components in bone marrow (BM) aspirates prior to chemotherapy, and in peripheral blood stem cell transplants (PBSCT). They were separated after the first (21/21 patients) and the second cycle (16/21 patients) of induction chemotherapy with VIP-E (etoposide, ifosfamide, cisplatin, epirubicin). Preliminary results showed CK positive tumor cells in 40% (14/35) of the analyzed transplants. In 7/12 (58.3%) patients, CK positive tumor cells were detectable in BM prior to treatment. Sixteen patients were separated after the 1st and 2nd cycle of VIP-E. PBSCT of 14/16 patients were assessable for presence of CK positive tumor cells. Our preliminary results demonstrate a lower tumor cell contamination of PBSCT separated after the 2nd cycle of induction therapy (14.3%) compared to contamination after the first induction therapy (64.3%). To date, 4/21 patients have experienced a relapse, and three of these patients had tumor cell positive transplants. Due to the small patient number only a trend towards a superior relapse-free survival in the patient group with CK negative transplants can be shown by Kaplan–Meier analysis.
Determining object geometry with compliance and simple sensors

To determine object geometry in unstructured environments, sensors must be mechanically robust, must exert only low forces on objects during exploration, and must be able to scan large regions efficiently without risk of damaging objects or sensors. Joint-angle sensors on compliant joints provide an appealing option for this task. An algorithmic framework is presented that allows them to be used for contact detection and to determine object geometry without requiring tactile arrays or other complicated contact location sensors. This volumetric approach to using proprioceptive sensors provides improvements in accuracy over other existing approaches based on the intersection of planes and lines.
Competitive inhibitors of human immunodeficiency virus reverse transcriptase

Nucleoside analogs continue to provide a rich source of potent and selective anti-HIV agents. The 5′-triphosphate forms of the clinically useful nucleosides are competitive inhibitors of retroviral reverse transcriptases and can result in the termination of chain elongation of proviral DNA. The function of viral reverse transcriptases and the mechanism of action of various compounds against HIV and hepatitis B virus are discussed. Insights in drug combination and viral resistance to nucleoside analogs are also provided with emphasis on novel enantiomers of nucleosides with the unusuall-configuration.
Typical Patterns in Atypical Anorexia Nervosa

Only a few published accounts describe atypical anorexia nervosa. To provide more information about this eating-disorder subtype, 15 patients (12 females, 3 males) with atypical anorexia nervosa were studied. In general, the 12 female patients were characterized by 1) older age at onset and presentation, 2) recurring bouts of depression, 3) numerous somatic complaints, 4) unmet dependency needs, and 5) little evidence of distortion in body image. The three male patients were characterized by a younger age at onset compared to the females, and in many ways they resembled young female anorexics or bulimic anorexics.
High toughness ceramics

Abstract The principal microstructural sources of toughening are reviewed, with emphasis on comparisons between theory and experiment. Process zone mechanisms, such as transformation and microcracking, as well as bridging mechanisms induced by either ductile phases or fibers and whiskers are afforded primary consideration. Microstructural variables which allow toughness optimization are discussed.
Autoimmune Markers in Diabetes

BACKGROUND: Type 1 diabetes (T1DM) results from cell-mediated autoimmune destruction of the β cells of the islets of Langerhans. Autoantibodies directed against the islets are useful clinical tools that allow the recognition and confirmation of β-cell autoimmunity. CONTENT: In this review we define the term “islet autoantibody,” describe the pathogenesis of autoantibody generation, and explain the uses of islet autoantibodies in clinical medicine and in research studies that concern the interruption or prevention of T1DM. We also discuss the biology of islet autoantibodies and their rates of appearance at the time of onset of T1DM and their appearance before the development of T1DM. SUMMARY: The presence of islet autoantibodies in persons with diabetes confirms an autoimmune etiology. In nondiabetic individuals, islet autoantibodies are strong predictors of the later development of T1DM.
Operant response requirements affect touching of visual reinforcement by infants

Studies of instrumental learning in infants have been concerned with negative transfer between noncontingent and contingent learning experiences, sparking debate about the value of responsive environments and calling for measures beyond operant performance to shed light on the underlying perception of contingency. The present studies focused on contingent versus non-contingent stimulation and their effect on attention and consummatory responses as unlearned features of the infant’s interaction with stimuli. In each experiment the dependent variable was tactile behavior directed toward pictures, and the independent variable was the type of contingency controlling the pictures. In Experiment 1, 12- to 18- month-old infants were tested in the laboratory using a modified discrete-trial operant procedure in which a touch-sensitive video screen served as both a projection surface and a touch-recording device. Infants touched contingent slides significantly more often than noncontingent slides. Experiment 2 extended this effect to fixed-ratio 1 (FR-1) versus fixed-ratio 2 (FR-2) schedules of reinforcement. A second group of 12- to 18-month-old infants showed a similar pattern; they touched the FR-2 slides significantly more often than the FR-1 slides. These findings indicate that factors other than operant behavior vary as a function of the degree of contingency in an instrumental situation, and hint at possible cognitive processes that compare contingency “rules” governing the responsiveness of a changing environment.
Replacing Projective Data Association with Lucas-Kanade for KinectFusion

We propose to overcome a significant limitation of the KinectFusion algorithm, namely, its sole reliance upon geometric information to estimate camera pose. Our approach uses both geometric and color information in a direct manner that uses all the data in order to perform the association of data between two RGBD point clouds. Data association is performed by aligning the two color images associated with the two point clouds by estimating a projective warp using the Lucas-Kanade algorithm. This projective warp is then used to create a correspondence map between the two point clouds, which is then used as the data association for a point-to-plane error minimization. This approach to correspondence allows camera tracking to be maintained through areas of low geometric features. We show that our proposed LKDA data association technique enables accurate scene reconstruction in environments in which low geometric texture causes the existing approach to fail, while at the same time demonstrating that the new technique does not adversely affect results in environments in which the existing technique succeeds.
Do we need a price index for industrial R&D?

Abstract Price deflators for research expenditures of 12 individual industries and of all U.S. industries combined are constructed for the period 1969–1988. These indexes are derived with a set of proxy price series that are highly correlated with surveyed R&D input prices, and that may be easily extended forward in time as the requisite proxy data become available. The approach could be replicated for other countries. Given the recent consideration to treat R&D as part of capital formation in satellite accounts to the international System of National Accounts and the U.S. National Income and Product Accounts, there is an immediate need for such deflators. Trends in U.S. industrial R&D expenditures utilizing these R&D deflators, and others found in the literature, are contrasted. Although broad-based deflators — such as the GNP deflator used in reporting most official R&D statistics provide reasonable approximations of changes in aggregate industry R&D costs, they are much less appropriate for calculating real R&D expenditures of individual industries. The industry-specific R&D indexes built here rather readily capture variations in inter-industry R&D cost trends that broader deflators miss.
Changing data, changing minds: What the data on cognitive sex differences tell us and what we hear

Abstract There is a widespread belief among the general public that females and males differ in many ways. Although the usual preference for environmentally-based explanations of these differences is, in part, a reaction against group-based prejudices, there is no justification for stereotypes or prejudices based on the finding that some areas of cognition show sex differences. New types of data are accumulating at a rapid rate that would logically require revised conclusions about the origins of cognitive sex differences. Despite large quantities of rapidly changing data, the willingness to embrace new sorts of judgments has been slow to follow. Sociocultural influences and personal tendencies to maintain a consistent belief system are identified as possible reasons why there is considerable disgreement in this area of research. Finally, practical applications for those concerned with the full development of human potential are offered.
The Use and Misuse of Orthogonal Regression in Linear Errors-in-Variables Models

Abstract Orthogonal regression is one of the standard linear regression methods to correct for the effects of measurement error in predictors. We argue that orthogonal regression is often misused in errors-in-variables linear regression because of a failure to account for equation errors. The typical result is to overcorrect for measurement error, that is, overestimate the slope, because equation error is ignored. The use of orthogonal regression must include a careful assessment of equation error, and not merely the usual (often informal) estimation of the ratio of measurement error variances. There are rarer instances, for example, an example from geology discussed here, where the use of orthogonal regression without proper attention to modeling may lead to either overcorrection or undercorrection, depending on the relative sizes of the variances involved. Thus our main point, which does not seem to be widely appreciated, is that orthogonal regression, just like any measurement error analysis, requires ...
Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice.

The contribution of adherens junction inactivation, typically by downregulation or mutation of the transmembrane core component E-cadherin, to cancer progression is well recognized. In contrast, the role of the desmosomal cadherin components of the related cell-cell adhesion junction, the desmosome, in cancer development has not been well explored. Here, we use mouse models to probe the functional role of desmosomal cadherins in carcinogenesis. Because mice lacking the desmosomal cadherin Desmoglein 3 (Dsg3) have revealed a crucial role for Dsg3 in cell-cell adhesion in stratified epithelia, we investigate the consequence of Dsg3 loss in two models of skin carcinogenesis. First, using Dsg3−/− keratinocytes, we show that these cells display adhesion defects in vitro and compromised tumor growth in allograft assays, suggesting that Dsg3 enables tumor formation in certain settings. In contrast, using an autochthonous model for SCC development in response to chronic UVB treatment, we discover a surprising lack of enhanced tumorigenesis in Dsg3−/− mice relative to controls, unlike mice lacking the desmosomal component Perp. Accordingly, there is no defect in the apoptotic response to UVB or enhanced immune cell infiltration upon Dsg3 loss that could promote tumorigenesis. Thus, Dsg3 does not display a clear function as a tumor suppressor in these mouse skin cancer models. Continued unraveling of the roles of Dsg3 and other desmosomal constituents in carcinogenesis in different contexts will be important for ultimately improving cancer diagnosis, prognostication, and treatment.
Roles of Ruva, Ruvc and Recg Gene Functions in Normal and DNA Damage-Inducible Replication of the Escherichia Coli Chromosome

Induction of the SOS response in Escherichia coli activates normally repressed DNA replication which is termed inducible stable DNA replication (iSDR). We previously demonstrated that initiation of iSDR requires the products of genes, such as recA, recB and recC, that are involved in the early stages of homologous recombination. By measuring the copy number increase of the origin (oriM1) region on the chromosome, we show, in this study, that initiation of iSDR is stimulated by mutations in the ruvA, ruvC and recG genes which are involved in the late stages of homologous recombination. Continuation of iSDR, on the other hand, is inhibited by these mutations. The results suggest that Holliday recombination intermediates, left on the chromosome due to abortive recombination, arrest replication fork movement. Low levels of iSDR and sfiA (sulA) gene expression were also observed in exponentially growing ruvA, ruvC and recG mutants, suggesting that the SOS response is chronically induced in these mutants. We propose that replication forks are arrested in these mutants, albeit at a low frequency, even under the normal (uninduced) conditions.
Strategic Liquidity Provision in Limit Order Markets

We characterize and prove the existence of Nash equilibrium in a limit order market with a finite number of risk-neutral liquidity providers. We show that if there is sufficient adverse selection, then pointwise optimization (maximizing in p for each q) in a certain nonlinear pricing game produces a Nash equilibrium in the limit order market. The need for a sufficient degree of adverse selection does not vanish as the number of liquidity providers increases. Our formulation of the nonlinear pricing game encompasses various specifications of informed and liquidity trading, including the case in which nature chooses whether the market-order trader is informed or a liquidity trader. We solve for an equilibrium analytically in various examples and also present examples in which the first-order condition for pointwise optimization does not define an equilibrium, because the amount of adverse selection is insufficient.
Microstructure and ultimate properties of injection molded amorphous engineering plastics: Poly(ether imide) and poly(2,6‐dimethyl‐1,4‐phenylene ether)

Specimens of two engineerig plastics i.e., poly(ether imide), PEI, and poly(2,6-dimethyl- 1,4-phenylene ether), PPE, were injection molded employing a 40t Van Dorn injection molding machine and industrial practices. The mold and melt temperatures and the injection speed were varied in a limited range which furnished acceptable samples. The density, birefringence, residual stress distributions, flexure and tensile properties, and crack development of the injection molded specimens were studied. Vacuum compression molded samples were also prepared to investigate the role played by the cooling rate in shaping microstructural distributions. The results revealed significant differences in the development of microstructure of the molded specimens of the two resins, which was related to rheology and molding conditions on one hand and to development of cracks and ultimate properties on the other hand.
Which patients pursue fertility preservation treatments? A multicenter analysis of the predictors of fertility preservation in women with breast cancer.

Objective To evaluate predictors of undergoing fertility preservation treatment (FPT) in women with breast cancer. Design Secondary analysis of a clinical database. Setting Three academic fertility preservation centers. Patient(s) One hundred eight patients with breast cancer undergoing FPT and 77 patients with breast cancer not undergoing FPT from 2005 to 2010. Intervention(s) None. Main Outcome Measure(s) Patients’ demographic and medical information. Result(s) Women who had FPT were older, wealthier, and had lower cancer stage compared with women who did not have FPT. The rate of the administration of neoadjuvant chemotherapy (NAC) was significantly lower in women who underwent FPT. After adjusting for age, body mass index (BMI), income, cancer stage, and center, a negative correlation persisted between NAC and FPT (odds ratio 0.091, 95% confidence interval 0.009–0.904). When we stratified the women by center, women at center 1 had a significantly lower FPT rate, lower parity, higher BMI, more advanced cancer stage, and lower income compared with centers 2 and 3. The rates of NAC were significantly higher in center 1. Conclusion(s) Although age, BMI, income, cancer stage, center, and NAC seem to be associated with undergoing FPT, NAC is the only modifiable variable. Because NAC restricts the time available for FPT, oncologists may consider offering adjuvant chemotherapy, except in cases in which NAC clearly improves survival, in women who are interested in FPT.
Experimental Ochratoxicosis in Turkey Poults

Abstract Graded concentrations of ochratoxin A (0, 1, 2, 4, and 8 γg/g of feed) incorporated into the diet of turkey poults from hatching until 3 weeks of age resulted in a decreased growth rate, enlarged proventriculus and gizzard, and a regressed thymus (all at 4 and 8 γg/g) and the sizes of liver, spleen, pancreas, kidneys, bursa of Fabricius were unaffected. Feed conversion ratio increased from 1.63 (control value) to 2.07 (8 γg/g) Mortality was increased significantly (P
Chronic Stress in Children and Adolescents.

(1983). Chronic stress in children and adolescents. Theory Into Practice: Vol. 22, Coping with Stress, pp. 48-56.
Kinetics of the isotopic halogen exchange between trans-dichlorobisethylenediamine platinum (IV) ion and aqueous chloride

The exchange of chloride ion with trans-Pt(en)2Cl22+ has been shown to follow a first order rate law with respect to both reactants and catalysts. Both Pt(NH3)42+ and Pt(en)22+ are effective catalysts for the exchange, but K2PtCl4 and Pd(NH3)42+ are ineffective. The rate is independent of acidity but shows dependence on the ionic strength of the solution. The specific rate constant at 20°C, Eact, Fact, and Sact for the exchange are 3·91 × 101 l2 mole−2 sec−1, 8·01 kcal mole−1, 14·61 kcal mole−1, and −23·76 e.u. respectively.
Resource typing in Guru

This paper presents a resource typing framework for the Guru verified-programming language, in which abstractions for various kinds of program resources can be defined. Implemented examples include reference-counted data, mutable arrays, and heap-allocated mutable aliased data. The approach enables efficient, type-safe programming with mutable and aliased data structures, with explicit deallocation (not garbage collection). We evaluate performance of the approach with two verified benchmarks, one involving mutable arrays, and another involving FIFO queues.
The protective role of cellular glutathione peroxidase against trauma-induced mitochondrial dysfunction in the mouse brain

Reactive oxygen species are believed to participate in the pathogenesis of traumatic brain injury (TBI). To evaluate the role of cellular glutathione peroxidase (Gpx1), a selenium-containing enzyme functioning in reduction of hydrogen peroxide and alkyl hyperoxides, in protecting animals against TBI, a line of Gpx1 transgenic mice was generated. Overexpression of Gpx1 was found in many organs including the brain of the transgenic mice. This line of transgenic mice and knockout mice deficient in Gpx1 were used in a model of controlled cortical impact injury and the efficiency of oxidative phosphorylation in brain mitochondria was determined. Although a 2-mm depth of mechanical impact caused a drastic decrease in NAD-linked electron transfer activities and energy-coupling capacities in brain mitochondria of nontransgenic mice, the decrease in mitochondrial function was completely prevented by overexpression of Gpx1 in Gpx1 transgenic mice. In addition, a 1-mm deformation depth hardly affected brain mitochondrial function in wild-type (Gpx1+/+) mice, yet resulted in a significant decrease in mitochondrial bioenergetic capacity in brains of homozygous Gpx1 knockout (Gpx1-/-) mice. Further experiments showed that inclusion of calcium chelator egtazic acid in measurement of mitochondrial respiration could completely restore the efficiency of mitochondrial respiration in injured brains of nontransgenic mice and Gpx1-/- mice, suggesting that the observed mitochondrial dysfunction is a direct result of increase in mitochondrion-associated calcium, which is secondary to the increased oxidative stress. These studies not only establish the role of Gpx1 in preventing mitochondrial dysfunction in mouse brain after TBI, but also suggest the species of reactive oxygen responsible for this event.
Floating-point unit in standard cell design with 116 bit wide dataflow

The floating point unit of a S/390 CMOS microprocessor is described. It contains a 116 bit fraction data flow for addition and subtraction and a 64 bit-wide multiplier. Besides the register array, there are no other dataflow macros used; it is fully designed with standard cell books and is placed flat with a timing driven placement algorithm. This design method allows more 'irregular' structures than usually found in custom designs. An overview of the floating point unit is given and some interesting design items are shown: a 120 bit-wide true-complement adder with precounting of leading zero digits, a signed multiplier with bit-optimized Wallace tree, intensive forwarding in source equal target cases and the checking method.
Reliability of spot test kits for detecting lead in household dust.

Abstract There has been a long-standing need for a technique that can provide fast, accurate and precise results regarding the presence of hazardous levels of lead in settled house dust. Several home testing kits are now available. One kit manufactured by Hybrivet (LeadCheck Swabs) is advertised as able to detect lead dust levels that exceed the US Environmental Protection Agency's dust lead standard for floors (40 μg/ft2). The purpose of the study was to determine the ability of LeadCheck Swabs to instantly detect lead in dust above EPA's hazard standard. A trained risk assessor collected 200 LeadCheck Swab samples side-by-side with standard dust wipe samples. The result of the LeadCheck Swab (positive (pink or red) or negative (yellow to brown)) was compared with the laboratory results for the corresponding dust wipe (over or under 40 μg/ft2). The LeadCheck Swabs produced a false negative rate of 64% (95% confidence interval: 55%, 72%). The likelihood of a swab producing a false negative depended on substrate (painted or non-painted) and surface type (floor or sill). Changing the interpretation rule by classifying all swab colors except yellow as positive yielded lower false negative rates under some test conditions, but still produced high error rates. LeadCheck Swabs do not reliably detect levels of lead in dust above 40 μg/ft2 using published methods under field conditions. Further research into alternate methodologies and interpretation guidance is needed to determine whether the swabs can be appropriately used by consumers and others to test homes for lead dust hazards.
Return Differences between Trading and Non-Trading Hours: Like Night and Day

We use transaction-level data and decompose the US equity premium into day (open to close) and night (close to open) returns. We document the striking result that the US equity premium over the last decade is solely due to overnight returns; the returns during the night are strongly positive, and returns during the day are close to zero and sometimes negative. This day and night effect holds for individual stocks, equity indexes, and futures contracts on equity indexes and is robust across the NYSE and Nasdaq exchanges. Night returns are consistently higher than day returns across days of the week, days of the month, and months of the year. The effect is driven in part by high opening prices which subsequently decline in the first hour of trading.
Microfocused x-ray study on precipitate formation in the separator region of nonaqueous Li-O2 Batteries

Using a microfocused synchrotron X-ray diffraction (μ-XRD) method, we systematically investigated the distributions of insoluble lithium precipitates, which formed through electrolyte decomposition, separately in all three regions (cathode, separator, and anode) of failed batteries with a spatial resolution of 20 μm. We found unexpectedly that there was a significantly higher concentration (almost twice as much) of precipitates in the separator than in the cathode. SEM revealed that the precipitates grew on the separator fiber surface, ultimately obstructing the pores serving as the ion-transport channel. A “refurbished” battery, which was composed of a spent separator from a failed battery, showed a much higher overpotential and shorter cycle life than that found in a new battery.
Generalizing the dubins and reeds-shepp cars: Fastest paths for bounded-velocity mobile robots

What is the shortest or fastest path a mobile robot can follow between two configurations in the unobstructed plane? The answer to this fundamental question is only known analytically for a few planar mobile robots: the Dubins and Reeds-Shepp steered cars, the differential drive, and a particular omnidirectional robot. This paper explores the optimal trajectories for a general parameterized model of a mobile robot that includes each previously-studied vehicle as a special case. The model also allows characterization of the optimal trajectories for several other mobile robot designs for which the optimal trajectories have not been previously explored. The paper applies Pontryagin's Maximum Principle to the generalized robot to find necessary conditions that optimal trajectories must satisfy, and gives geometric interpretations of the conditions. We also present an algorithm that generates and classifies all optimal trajectories for a given design.
Design of stuck-open fault testable CMOS complex gates

Tests that detect transistor stuck-open (TSOP) faults independent of timing skews in input changes may not exist for all TSOP faults in CMOS complex gates. A new design method is presented which does not require any extra hardware or test inputs to improve the testability of a CMOS complex gate.