cssi/SciSciGPT-SciSciNet huggingface dataset:
Changing approaches to research synthesis affect social and intellectual structures of science

Research synthesis methods, like collaboration and interdisciplinary research, comprise practices through which scholarly and scientific knowledge is integrated. The methods, which include meta-analysis and integrative or systematic review, are also arguably one of the most important contemporary methodological innovations in many social, medical, health, and perhaps other sciences. As an innovative research practice, research synthesis, like many innovations, may be associated with complex or unexpected consequences as it diffuses through the research system. This study examines the extent to which the diffusion of research synthesis methods has affected levels of collaboration and research use through comparison with literature reviews in five fields. In Social Work and Information and Library Science, more authors contributed to research syntheses than reviews. There was no difference in number of authors in the biological sciences examined: two to four authors typically contributed to both reviews and syntheses. Research syntheses were used more than reviews in Conservation Biology and Women's Studies. In Social Work, research syntheses and reviews were cited at similar levels, but production of reviews decreased as syntheses increased, suggesting that research synthesis was becoming the predominant approach to review, while traditional reviews remained valuable to researchers though in an increasingly narrow range of contexts. In Information and Library Science, research reviews were used more than research syntheses, and trends suggest that research reviews are a relatively rare but highly prized - or at least frequently used - resource. No difference was found between use of research syntheses and reviews in Evolutionary Biology. Future research should investigate relationships between different approaches to knowledge integration in the context of science fields, which would lead to a better understanding of integration, or synthesis, in science overall.
The Future of the Superfund: Where is it Headed and How Will it Get There?

This paper is a critical analysis of the Environmental Protection Agencyâ€™s Superfund program, turned 25 last year. This paper will provide a historical overview of the programâ€™s development in managing environmental contamination. It will also discuss the more recent problems the program finds itself addressing. The corporate taxes that helped finance the Superfund Trust Fund expired in 1995. Now the question is: does the cleanup program still need $1.4 billion a year, or is it time to start cutting appropriations as the list of sites are completed? This paper will challenge the belief that current funding levels are sufficient to complete the cleanup of the remaining contaminated sites that exist throughout the nation. Specifically, five assumptions of those who argue for fewer appropriations will be thoroughly examined.
Adjacent-segment disease after thoracic pedicle screw fixation

OBJECTIVEPedicle screw fixation is a technique widely used to treat conditions ranging from spine deformity to fracture stabilization. Pedicle screws have been used traditionally in the lumbar spine; however, they are now being used with increasing frequency in the thoracic spine as a more favorable alternative to hooks, wires, or cables. Although safety concerns, such as the incidence of adjacent-segment disease (ASD) after cervical and lumbar fusions, have been reported, such issues in the thoracic spine have yet to be addressed thoroughly. Here, the authors review the literature on ASD after thoracic pedicle screw fixation and report their own experience specifically involving the use of pedicle screws in the thoracic spine.METHODSSelect references from online databases, such as PubMed (provided by the US National Library of Medicine at the National Institutes of Health), were used to survey the literature concerning ASD after thoracic pedicle screw fixation. To include the authors’ experience at Rutge...
Abstract P261: Intensive Systolic Blood Pressure Lowering Will Prevent Over 100,000 Deaths Annually

Background: The Systolic Blood Pressure Intervention Trial (SPRINT) trial randomized 9,361 adults aged ≥50 years at high cardiovascular disease (CVD) risk without diabetes or stroke to intensive systolic blood pressure (SBP) lowering (≤120 mmHg) or standard SBP lowering (≤140 mmHg). After a median follow up of 3.26 years, all-cause mortality was 27% (95% CI 40%, 10%) lower with intensive SBP lowering. We estimated the potential number of prevented deaths with intensive SBP lowering in the U.S. population meeting SPRINT criteria. Methods: SPRINT eligibility criteria were applied to the National Health and Nutrition Examination Survey 1999-2006, a representative survey of the U.S. population, linked with the mortality data through December 2011. Eligibility included (1) age ≥50 years with (2) SBP 130-180 mmHg depending on number of antihypertensive classes being taken, and (3) presence of ≥1 CVD risk conditions (history of coronary heart disease, estimated glomerular filtration rate (eGFR) 20 to 59 ml/min/1.73 m 2 , 10-year Framingham risk score ≥15%, or age ≥75 years). Adults with diabetes, stroke history, >1 g/day proteinuria, heart failure, on dialysis, or eGFR 2 were excluded. Annual mortality rates for adults meeting SPRINT criteria were calculated using Kaplan-Meier methods and the expected reduction in mortality rates with intensive SBP lowering in SPRINT was used to determine the number of potential deaths prevented. Analyses accounted for the complex survey design. Results: An estimated 18.1 million U.S. adults met SPRINT criteria with 7.4 million taking blood pressure lowering medications. The mean age was 68.6 years and 83.2% and 7.4% were non-Hispanic white and non-Hispanic black, respectively. The annual mortality rate was 2.2% (95% CI 1.9%, 2.5%) and intensive SBP lowering was projected to prevent 107,453 deaths per year (95% CI 45,374 to 139,490). Among adults with SBP ≥145 mmHg, the annual mortality rate was 2.5% (95% CI 2.1%, 3.0%) and intensive SBP lowering was projected to prevent 60,908 deaths per year (95% CI 26, 455 to 76, 792). Conclusions: We project intensive SBP lowering could prevent over 100,000 deaths per year of intensive treatment.
SIGCHI Lifetime Practice Award Talk -- Riding the Wave

I'm an optimist. I entered our field believing that we can use technology to make people's lives better, and agreeing with Lincoln, Drucker, Kay and others that "The best way to predict your future is to create it." For HCI, as the technological tools we have available to design experiences have evolved, our impact has moved from its initial focus on human factors, fitting systems to users (efficiency and effectiveness), to 2nd wave considerations of people in community and the rich context of life, and delight and identity. Third wave HCI recognizes the growing ubiquity of a digital world as the new context that we shape and are shaped by, and its ability to touch every aspect of what it is to be human. It is the ecosystem of digital products that many of us are creating with maturing and diverse design perspectives that is enriching lives. There has certainly been a dark side of those left behind, unintended consequences and apparent failures of promising innovations. In this talk I will be reflecting on lessons learned through these waves of evolution in our field. I'll also be sharing what I believe are some of the properties of the wave that could come if we embrace the transformative power of the next generation of technology to address the toughest social issues we face by baking universal design into the fabric of the digital world.
Role Conflict and the Psychological Impacts of the Post-Ferguson Period on Law Enforcement Motivation, Cynicism, and Apprehensiveness

In the wake of high-profile deadly force cases in the post-Ferguson era, a number of negative psychological outcomes have been depicted by law enforcement officers. We examine if negative post-Ferguson outcomes predict current cynicism, motivation, and apprehensiveness. Further, we account for whether role orientations, specifically support for a law enforcement orientation or a community policing orientation, mediate the psychological effects of the post-Ferguson period. Since the law enforcement orientation, exercised through strict enforcement of the law, has been called out of favor in the post-Ferguson area, supporting this role may negatively impact officers via role conflict. The opposite may be observed for those supporting a community policing orientation. We test these arguments using results from an online survey of law enforcement officers in the USA, administered 6 months following highly publicized incidents in Dallas and Baton Rouge where police were targeted and killed. Results showed that post-Ferguson psychological impacts continued to affect current levels of cynicism, motivation, and apprehensiveness. Support for law enforcement or community policing orientation did not mediate the effects of post-Ferguson sentiments. Nonetheless, role orientations played a significant role in predicting current cynicism, motivation, and apprehensiveness and provided support for the theory of role conflict.
Benign Bone Tumors

Lesions and proliferations throughout the musculoskeletal system are extremely common but rarely manifest into complications. Although they do not behave aggressively locally, that can at times become symptomatic and result in pathologic fracture.
Clinical and Psychosocial Characteristics of Young Children With Suicidal Ideation, Behaviors, and Nonsuicidal Self-Injurious Behaviors.

Objective Based on previous findings that suicidal ideation (SI) and behavior (SB) arose in depressed preschoolers and showed stability into school age, we sought to investigate whether unique clinical and psychosocial correlates of SI/SB and nonsuicidal self-injurious behaviors (NSSI) could be identified in young children recuited into a depression treatment study and healthy controls. Method Data from 288 children 3.0 to 6.11 years of age who were recruited for participation in a psychotherapy treatment study of depression and 26 healthy control subjects (total N = 314) were used. At baseline, subjects received a comprehensive assessment of psychopathology and suicidal ideation/suicidal behavior. Multinominal logistic regressions were conducted comparing those with no SI/SB/NSSI to those with SI/SB or NSSI. Those with SI/SB who also had NSSI were placed in the SI/SB group. Results In this sample of young children, the rates of NSSI, SI, and SB were 21.3%, 19.1%, and 3.5% respectively. Children with SI/SB or NSSI experienced a greater frequency of violent life events than children with no SI/SB/NSSI. Children with SI/SB had significantly more preoccupation with death compared to subjects with NSSI and subjects with no SI/SB/NSSI. Children with SI/SB had more vegetative signs of depression and greater depression severity, and those with NSSI were more irritable with higher depression severity than those with no SI/SB/NSSI. Conclusion Distinct characteristics of SI/SB and NSSI in early childhood were identified, informing high risk subgroups. Findings suggest that clinicians should be aware of the potential for SI/SB and/or NSSI in young children and should directly address these symptoms in clinical interviews. Clinical trial registration information: A Randomized Controlled Trial of PCIT-ED for Preschool Depression. https://clinicaltrials.gov/ ; NCT02076425 .
Variable external forcing obscures the weak relationship between the NAO and North Atlantic multidecadal SST variability

AbstractNorth Atlantic sea surface temperatures (SST) exhibit a lagged response to the North Atlantic Oscillation (NAO) in both models and observations, which has previously been attributed to chan...
Neurotrophic Proteins in Dentin and Their Effect on Trigeminal Sensory Neurons

Abstract Introduction A plethora of bioactive molecules present during tooth formation become sequestered in the mineralized dentin matrix and can be released into the pulp tissue after demineralization from carious lesions. However, neurotrophic factors are differentially expressed and secreted during various stages of odontogenesis. Thus, the aims of this study were (1) to investigate their presence and relative abundance in crown and root dentin and (2) to evaluate the bioactivity of dentin-derived proteins on neuronal cells. Methods Dentin matrix proteins (DMPs) were isolated from matched roots and crowns of extracted healthy human third molars. The total protein amount as well as the concentration of growth factors and neurotrophic proteins were quantified. The impact on neuritogenesis was determined with mouse trigeminal neurons in vitro and by a hydrogel implant model in vivo. Transient receptor potential cation channel subfamily V member 1 (TRPV1) sensitization of DMP-conditioned neurons was evaluated by single-cell calcium imaging. Results The relative concentration of neurotrophic molecules revealed that nerve growth factor is the most abundant neurotrophin with 3-fold increased expression in radicular dentin. Similarly, brain-derived neurotrophic factor and neurotrophin 3 are more abundant in radicular than coronal dentin. Conversely, glial cell line–derived neurotrophic factor is more abundant in coronal dentin, whereas neurotrophin 4 is equally distributed. Dentin matrix proteins promoted neurite outgrowth in vitro and axonal targeting in vivo, with a greater effect observed by radicular dentin extracts. Furthermore, DMPs sensitized TRPV1 responses in mouse trigeminal neurons with greater activity seen with extracts from root dentin. Conclusions Neurotrophic factors are differentially distributed between coronal and radicular dentin with different effects of dentin-derived proteins on axonal growth and targeting as well as the sensitization of TRPV1. Thus, extracellular proteins from the dentin matrix are likely involved in neurogenic responses to caries and could be exploited in clinical regenerative endodontics to promote reinnervation and enhance tissue regeneration.
Oil source and peroxidation status interactively affect growth performance and oxidative status in broilers from 4 to 25 d of age

ABSTRACT The objectives of this experiment were to evaluate the effect of oil source and peroxidation status on broiler performance and oxidative stress. Broilers (initial BW 85.1 ± 7.8 g) were allotted to 40 cages with 5 birds per cage in a completely randomized design. The 4 × 2 factorial arrangement of treatments consisted of oil source (palm oil, soybean oil, flaxseed oil, and fish oil) and peroxidation status (fresh or peroxidized). Broilers were fed experimental diets for 20 d to measure growth performance; on day 21 of the experiment, plasma and liver samples were harvested for analysis of oxidative stress including thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC), 8-hydroxy-2'-deoxyguanosine (8- OH-2dG), glutathione peroxidase activity (GPx) and superoxide dismutase and catalase (CAT). An interaction occurred between oil source and peroxidation status where broilers fed peroxidized oils had reduced ADFI, ADG, G:F, and plasma GPx in all oil sources except for fish oil (P ≤ 0.04). Plasma 8-OH-2dG was increased by feeding peroxidized oils (P = 0.01). An interaction occurred in liver TBARS where broilers fed peroxidized palm oil had greater liver TBARS compared to fresh palm oil (P = 0.09). An interaction was noted for liver PC where broilers fed palm, flaxseed, and fish oil had similar liver PC regardless of peroxidation status, while broilers fed peroxidized soybean oil had increased liver PC compared to the fresh soybean oil diet (P = 0.04). Oil source affected plasma TBARS and 8-OH-2dG (P = 0.01), plasma PC (P = 0.09), liver 8-OH-2dG (P = 0.08), and liver CAT (P = 0.02). Correlations between oil composition with growth performance and oxidative stress markers imply that oil UFA:SFA, p-anisidine value, DDE, total polar compounds, and polymerized triglycerides should be measured as an indicator of oil quality, with growth performance being correlated to plasma TBARS, PC, and GPx. In conclusion, the degree of unsaturation and peroxidation status of dietary oils affected growth performance and markers of oxidative stress in poultry.
How to Define Successful Stocking of Florida’s Freshwater Recreational Fisheries

Florida researchers and fisheries management agencies have conducted years of research on stocking, a common and popular but intensive option for improving recreational fisheries, but determining how successful it has been in Florida has been challenging. This 7-page fact sheet written by Edward V. Camp, Rick Stout, Nick Trippel, Jon Fury, Stasey Whichel, and Kai Lorenzen and published by the UF/IFAS School of Forest Resources and Conservation Program in Fisheries and Aquatic Sciences reviews recent scientific literature to describe the benefits of stocking and the potential drawbacks to create useful definitions of stocking success, as well as metrics for evaluation that are specifically tailored for Florida. Well-planned stocking can not only improve recreational fishing but achieve broader research and management goals and help us to understand how fisheries function, both biologically and socioeconomically. http://edis.ifas.ufl.edu/fa216
Will the Crowd Go Wild?: Reimagining the Newspaper Sports Section for Digital Subscribers

The economic troubles facing the media industry have led newspapers to search for new revenue models. At least one major American media company has made a big bet on digital subscriptions, includin...
The state of educational leadership in the United States: trends and implications for higher education and local school districts

Educational leadership programs are designed to enhance the skills of educational leaders working in a variety of executive positions at the primary, secondary, and postsecondary levels. Specifical...
Occult Nodal Metastases in Patients Down-Staged to Nonmuscle Invasive Disease Following Neoadjuvant Chemotherapy.

Objectives To evaluate the risk of occult nodal metastasis in patients with muscle invasive bladder cancer who exhibit a complete or partial clinical response to neoadjuvant chemotherapy (NAC) and assess a potential role for “bladder sparing” management given that the gold standard treatment, radical cystectomy (RC), is associated with high morbidity. Methods We queried the National Cancer Database for bladder cancer from 2004 to 2013 including patients with cT2-4aN0M0 bladder cancer who underwent multiagent NAC followed by RC and pelvic lymphadenectomy and excluding patients with nonurothelial predominant histology and those undergoing partial cystectomy. Student's t test was used to evaluate patients’ demographics, presence of co-morbid conditions, and pathologic findings, notably the presence of lymphovascular invasion and variant histology. Results We identified 17,917 patients who underwent RC. Of these, 14.9% (n = 2673) received NAC before RC. About 13.1% and 14.5% of patients had complete (ypT0) and partial (ypTa, Tis, and T1) pathologic response, respectively. These 14.7% of cT2, 9.0% of cT3, and 6.9% of cT4 patients exhibited pT0 status on final pathology. And 4.9% of complete and 5.4% of partial responders demonstrated occult nodal metastases. Age, sex, ethnicity, the presence of co-morbidities, LVI, and variant histology were not significantly associated with occult nodal metastasis. Conclusion While bladder preservation may be a viable option in patients who are carefully selected and closely followed after NAC, patients undergoing NAC may be at risk of occult disease outside of the bladder despite an otherwise clinical complete response diagnosed with cross-sectional imaging, cystoscopy, TURBT, and cytology.
Influenza vaccine effectiveness among outpatients in the US Influenza Vaccine Effectiveness Network by study site 2011-2016.

Background Influenza vaccination is recommended for all US residents aged ≥6 months. Vaccine effectiveness (VE) varies by age, circulating influenza strains, and the presence of high-risk medical conditions. We examined site-specific VE in the US Influenza VE Network, which evaluates annual influenza VE at ambulatory clinics in geographically diverse sites. Methods Analyses were conducted on 27 180 outpatients ≥6 months old presenting with an acute respiratory infection (ARI) with cough of ≤7-day duration during the 2011-2016 influenza seasons. A test-negative design was used with vaccination status defined as receipt of ≥1 dose of any influenza vaccine according to medical records, registries, and/or self-report. Influenza infection was determined by reverse-transcription polymerase chain reaction. VE estimates were calculated using odds ratios from multivariable logistic regression models adjusted for age, sex, race/ethnicity, time from illness onset to enrollment, high-risk conditions, calendar time, and vaccination status-site interaction. Results For all sites combined, VE was statistically significant every season against all influenza and against the predominant circulating strains (VE = 19%-50%) Few differences among four sites in the US Flu VE Network were evident in five seasons. However, in 2015-16, overall VE in one site was 24% (95% CI = -4%-44%), while VE in two other sites was significantly higher (61%, 95% CI = 49%-71%; P = .002, and 53%, 95% CI = 33,67; P = .034). Conclusion With few exceptions, site-specific VE estimates aligned with each other and overall VE estimates. Observed VE may reflect inherent differences in community characteristics of the sites and highlights the importance of diverse settings for studying influenza vaccine effectiveness.
Mask-Wearing Increased After a Government Recommendation: A Natural Experiment in the U.S. During the COVID-19 Pandemic

On April 3 2020, the U.S. Centers for Disease Control and Prevention (CDC) recommended that all Americans wear face masks to prevent the spread of COVID-19. The announcement came during the fielding of a large, nationally-representative survey (N = 3,933) of Americans’ COVID-19-related knowledge, attitudes, and behaviors, providing an opportunity to measure the impact of the CDC’s recommendation on public reported mask wearing and buying behavior. The study found significant increases in reported mask wearing (+12 percentage points) and mask buying (+7 points). These findings indicate the speed with which government recommendations can affect the adoption of protective behaviors by the public. The results demonstrate the importance of national leadership and communication during a public health crisis.
Family nurture intervention in the NICU increases autonomic regulation in mothers and children at 4-5 years of age: Follow-up results from a randomized controlled trial.

Background Maturation of multiple neurobehavioral systems, including autonomic regulation, is altered by preterm birth. The purpose of this study was to determine the long-term effects of Family Nurture Intervention (FNI) in the NICU on autonomic regulation of preterm infants and their mothers. Method A subset of infants and mothers (48% of infants, 51% of mothers) randomly assigned to either standard are (SC), or SC plus the FNI in the NICU in a prior RCT (ClincalTrials.gov; NCT01439269) returned for follow-up assessments when the children were 4 to 5 years corrected age (CA). ECGs were collected for 10 minutes in mothers and their children while children were in their mothers’ laps. Heart rate, standard deviation for heart rate, respiratory sinus arrhythmia (RSA)–an index of parasympathetic regulation, and a measure of vagal efficiency were quantified. Results Both children and mothers in the FNI group had significantly greater levels of RSA compared to the SC group (child: mean difference = 0.60, 95% CI 0.17 to 1.03, p = 0.008; mother: mean difference = 0.64, 95% CI 0.07 to 1.21, p = 0.031). In addition, RSA increased more rapidly in FNI children between infancy and the 4 to 5-year follow-up time point (SC = +3.11±0.16 loge msec2, +3.67±0.19 loge msec2 for FNI, p<0.05). These results show that the rate of increase in RSA from infancy to childhood is more rapid in FNI subjects. Conclusion Although these preliminary follow-up results are based on approximately half of subjects originally enrolled in the RCT, they suggest that FNI-NICU led to healthier autonomic regulation in both mother and child, when measured during a brief face-to-face socioemotional interaction. A Pavlovian autonomic co-conditioning mechanism may underly these findings that can be exploited therapeutically.
Are sexual minority adults differentially exposed to smoke-free laws and televised anti-tobacco media campaigns compared to the general US population? A descriptive analysis.

Background Sexual minority (SM) (gay, lesbian and bisexual) adults are at higher risk of smoking compared with heterosexual individuals, yet little is known about how the tobacco control policy landscape interacts with sexual orientation smoking disparities. Methods We conducted a descriptive analysis to explore differential exposure to smoke-free laws and televised anti-tobacco media using two sources of national data from the United States: Census data on same-sex couple households/all households and data on SM adults/all adults from the National Health Interview Survey (NHIS). We combined this information with variables representing the proportion of individuals in each county covered by smoke-free laws (2013–2017), and average county-level exposure to televised anti-tobacco media campaigns (2013–2015). We compared average coverage levels for SM populations to average coverage levels for the broader US population. Results Between 2013 and 2017, same-sex couple households/SM adults lived in counties with higher levels of smoke-free law coverage compared with all US households/adults for workplaces (Census: 71.3% vs 68.0%; NHIS: 70.7% vs 67.9%) and hospitality venues (Census: 82.3% vs 77.0%; NHIS: 80.5% vs 77.2%). There were no consistent differences in exposures to anti-tobacco media campaigns across datasets. Conclusions SM adults may be more likely to live in areas with smoke-free laws, compared with the general population. Findings point to the need to examine other potential drivers of smoking in SM populations.
Revealing How Color Vision Phenotype and Genotype Manifest in Individual Cone Cells.

Purpose Psychophysical and genetic testing provide substantial information about color vision phenotype and genotype. However, neither reveals how color vision phenotypes and genotypes manifest themselves in individual cones, where color vision and its anomalies are thought to originate. Here, we use adaptive-optics phase-sensitive optical coherence tomography (AO-PSOCT) to investigate these relationships. Methods We used AO-PSOCT to measure cone function-optical response to light stimulation-in each of 16 human subjects with different phenotypes and genotypes of color vision (five color-normal, three deuteranopic, two protanopic, and six deuteranomalous trichromatic subjects). We classified three spectral types of cones (S, M, and L), and we measured cone structure-namely cone density, cone mosaic arrangement, and spatial arrangement of cone types. Results For the different phenotypes, our cone function results show that (1) color normals possess S, M, and L cones; (2) deuteranopes are missing M cones but are normal otherwise; (3) protanopes are missing L cones but are normal otherwise; and (4) deuteranomalous trichromats are missing M cones but contain evidence of at least two subtypes of L cones. Cone function was consistent with the subjects' genotype in which only the first two M and L genes in the gene array are expressed and was correlated with the estimated spectral separation between photopigments, including in the deuteranomalous trichromats. The L/M cone ratio was highly variable in the color normals. No association was found between cone density and the genotypes and phenotypes investigated, and the cone mosaic arrangement was altered in the dichromats. Conclusions AO-PSOCT is a novel method for assessing color vision phenotype and genotype in single cone cells.
U.S. Federal Genomic Data Release and Access Policies

Researchers today have access to a vast aggregation of human and nonhuman genomic data, largely on an open access basis. According to the Joint Genome Institute’s Genomes OnLine Database (GOLD), data from more than 40,000 sequencing projects around the world, representing more than 375,000 different organisms, were publicly available to researchers as of July 2020. The availability of this tremendous public resource is due, in large part, to the data release policies developed a quarter century ago, toward the beginning of the Human Genome Project (HGP), which have been carried forward, in modified form, to the present. These policies impose requirements on both the generators of data (typically the sequencing centers and other laboratories conducting genetic experiments) and the users of that data (i.e., researchers who download and/or use it). This chapter, briefly outlines the history of such data release policies, particularly in the U.S. and with respect to human genomic data, and provides an overview of the obligations imposed on both data generators and data users.
Elastohydrodynamic friction of robotic and human fingers on soft micropatterned substrates.

Frictional sliding between patterned surfaces is of fundamental and practical importance in the haptic engineering of soft materials. In emerging applications such as remote surgery and soft robotics, thin fluid films between solid surfaces lead to a multiphysics coupling between solid deformation and fluid dissipation. Here, we report a scaling law that governs the peak friction values of elastohydrodynamic lubrication on patterned surfaces. These peaks, absent in smooth tribopairs, arise due to a separation of length scales in the lubricant flow. The framework is generated by varying the geometry, elasticity and fluid properties of soft tribopairs and measuring the lubricated friction with a triborheometer. The model correctly predicts the elastohydrodynamic lubrication friction of a bioinspired robotic fingertip and human fingers. Its broad applicability can inform the future design of robotic hands or grippers in realistic conditions, and open up new ways of encoding friction into haptic signals. A framework for the elastohydrodynamic lubrication between soft patterned surfaces identifies the contributions of substrate elasticity and pattern geometry for friction, which have implications for the engineering of haptic soft materials.
[Compartment syndrome of the forearm after intra-arterial self-injection : With a mixture of methadone, flunitrazepam, saliva and water].

A drug-addicted patient injected himself intra-arterially with a mixture of methadone, flunitrazepam, saliva and water. The resulting compartment syndrome could be treated by fasciotomy and multiple debridement, with which a major amputation could be prevented. The course of the treatment and the resulting functional results are described, as well as a brief overview of the literature and a treatment proposal for similar cases.
Mentoring practices, developmental networks, and doctoral science training experiences

The realization that mentoring during doctoral science training is provided by a variety of actors beyond the traditional doctoral adviser/mentor led us to empirically verify, using confirmatory factor analysis and normal error regression analysis, whether developmental networks (DNs) assist in enriching the doctoral training experiences of those who aspire to be scientists (i.e., doctoral science students). We analyzed data from face-to-face interviews we conducted with 115 chemical science doctoral students at selected elite universities in Japan, Singapore, and Taiwan. We schematized a measure of DN types from an egocentric name-generator. That measure was based on diversity of alters' sector of science (i.e., academia, government, industry) and tie strength. Despite the salience of the doctoral mentor and the recognition of DNs in providing support to students in Western training systems, we observed that the doctoral mentor remains to be the central influential actor in doctoral students’ training experiences in the non-West. In contrast to studies on Western scientific training systems, our results suggest that the contribution, influence, salience, and role of doctoral mentors and DNs in the training experiences of doctoral students are shaped by the larger sociocultural context in which scientific training systems are embedded.
Antibacterial Envelope Use for the Prevention of Surgical Site Infection in Spinal Cord Stimulator Implantation Surgery: A Retrospective Review of 52 Cases.

Objective Surgical site infection in patients who undergo spinal cord stimulator implant surgery represents a significant concern in terms of increased health care costs and patient morbidity. The use of antibacterial envelopes in spinal cord stimulator implant surgeries has not been previously described. The aim of this retrospective review was to evaluate the effectiveness of the antibacterial envelope in reducing surgical site infection in spinal cord stimulator implant surgeries when used adjunctively to standard infection prevention measures. Materials and Methods The study included 52 patients, all of whom were implanted with a spinal cord stimulator between January 2015 and November 2020. To be included, patients were required to have had an antibacterial envelope utilized at the time of surgery. Patient records were retrospectively reviewed. All patients who received an antibacterial envelope at the time of implant surgery were included. Results Data was collected and analyzed on 52 permanent SCS implantations, including primary implantation (n=26) and revision surgery (n=26). All patients were at least three months post-operative from the implant surgery (average follow-up time period was 518.4 days). There were no surgical site infections reported in the 52 patient cohort. Conclusion Antibiotic impregnated envelopes appear to be a safe and effective modality to decrease surgical site infection risk in spinal cord stimulation implant surgeries.
Race and Ethnicity in Contemporary Vietnam

Vietnam is a nation-state located in Southeastern Asia, sharing borders with Cambodia and Laos to the west, China to the north, the Gulf of Tonkin to the east, and the South China Sea to the south. It spans more than 331,210 sq. km, which compares in size to New Mexico in the United States. It is a country historically rife with conflict. In part, this can be traced to ongoing legacies of colonialism. The following chapter is organized under five general themes: (1) general demographic trends, (2) Vietnam in the racialized world system, (3) ethnic conflict and inequality in Vietnam, (4) intergroup conflict outside of Vietnam, and (5) future trends and what can be expected. In each of these sections, we sketch an empirical overview describing various historical and contemporary trends, and then we offer some theoretical assessments and explanations of these data. Though our analysis is not exhaustive, it nonetheless highlights a number of social problems that merit further examination and scrutiny if ethnic inequality in Vietnam is to be reduced.
Studies in animal models of osteoarthritis as predictors of a structure-modifying effect of diacerhein in humans with osteoarthritis

In addressing the use of animal models of osteoarthritis (OA) for predicting a structure-modifying effect of the anthraquinone derivative, diacerhein (DAR) (Fig. 1), in humans with OA, it is worth considering at the outset the context for the use of animal models, in general, as predictors of drug effects in humans with OA. In this vein, the excellent chapter by Doherty et al. [6] on the limitations of animal models in OA research provides excellent background. Paradigms of drug development based on animal models rely chiefly on demonstration of therapeutic activity in an animal model of the human disease to justify moving on to evaluation of the compound in man. In contrast, mechanism-based paradigms involve identification of a specific target (e.g., cytokine, enzyme, receptor) that is presumed to be important in the human disease and the selection of compounds that have appropriate activities against the target in vitro in assays utilizing appropriate human reagents, ensuring that the compound possesses the necessary pharmacodynamic properties. Promising compounds may then be evaluated in humans without a requirement for demonstration of therapeutic efficacy in an animal model of the disease. Drug development schemes that rely on animal models can be confounded by false positive and false negative results, partly because species differences with respect to the relative contribution of various mediators, receptors or enzymes to the pathology are common. For example, antihistamines are efficacious in treating asthma in guinea pigs but not in humans; prostaglandin inhibitors (e.g., indomethacin)
Quality expectation-variance tradeoffs in crowdsourcing contests

We examine designs for crowdsourcing contests, where participants compete for rewards given to superior solutions of a task. We theoretically analyze tradeoffs between the expectation and variance of the principal's utility (i.e. the best solution's quality), and empirically test our theoretical predictions using a controlled experiment on Amazon Mechanical Turk. Our evaluation method is also crowdsourcing based and relies on the peer prediction mechanism. Our theoretical analysis shows an expectation-variance tradeoff of the principal's utility in such contests through a Pareto efficient frontier. In particular, we show that the simple contest with 2 authors and the 2-pair contest have good theoretical properties. In contrast, our empirical results show that the 2-pair contest is the superior design among all designs tested, achieving the highest expectation and lowest variance of the principal's utility.
Using simulation-based inference for learning introductory statistics

Recent curriculum development projects emphasize teaching simulation and randomization-based statistical inference as a prominent feature in introductory statistics courses. We describe the goals, distinctive features, and examples from some of these projects. Technology is a key component of these courses, so we mention desirable features of the various technology products used with this approach. We also discuss how student learning is being assessed in such courses, along with how the curriculum effort itself is being evaluated. We also touch on some challenges that we have encountered with teaching these courses, both from a student and a faculty viewpoint. WIREs Comput Stat 2014, 6:211-221. doi: 10.1002/wics.1302
Optical anisotropy of porous polymer film with inverse slanted nanocolumnar structure revealed via generalized spectroscopic ellipsometry

We use generalized spectroscopic ellipsometry to characterize the biaxial optical properties of porous polymer and slanted nanocolumnar template thin films. The porous polymer with inverse columnar structure was prepared via infiltrating polymer into the voids of the slanted nanocolumnar film and selectively removing the column material (cobalt). The anisotropic Bruggeman effective medium approximation was employed to analyze the ellipsometry data of the porous polymer film and nanocolumnar template. The classification and structure of optical anisotropy are found to be identical for both samples. The interchangeable optical behaviors between two complementary structures are attributed to the equivalency in their anisotropic polarizabilities.
Protein Aggregation, Denaturation

Introduction Methods for Measuring Solubility and Protein Association Combining Methods to Follow Aggregation and Precipitation and Determine the Structure of Complexes Characterizing Protein–Solvent Interactions Protein Stability in a Practical Sense Determining the Surface Charge and Hydrophobicity of a Protein Empirical Models for Salting-in and Precipitation with Various Agents Models for Determining the Effect of Co-solvents on Protein Folding Computer Design of More Soluble Proteins Automatic Homology Modeling Modeling Using Self-Correcting Distance Geometry with the Programs CLUSTAL, MASIA, NOAH, DIAMOD, and FANTOM to Develop a 3-D Model of a Protein Modeling Complexes Protein Design Conclusion Acknowledgments Bibliography Keywords: aggregation; biophysical techniques; co-solvent effects; homology modeling; kinetics; measuring; protein folding; surface force; three-dimensional structure
Cooperation among Multiple Transcription Factors Is Required for Access to Minimal T-Cell Receptor α-Enhancer Chromatin In Vivo

To understand the molecular basis for the dramatic functional synergy between transcription factors that bind to the minimal T-cell receptor α enhancer (Eα), we analyzed enhancer occupancy in thymocytes of transgenic mice in vivo by genomic footprinting. We found that the formation of a multiprotein complex on this enhancer in vivo results from the occupancy of previously identified sites for CREB/ATF, TCF/LEF, CBF/PEBP2, and Ets factors as well as from the occupancy of two new sites 5′ of the CRE site, GC-I (which binds Sp1 in vitro) and GC-II. Significantly, although all sites are occupied on a wild-type Eα, all sites are unoccupied on versions of Eα with mutations in the TCF/LEF or Ets sites. Previous in vitro experiments demonstrated hierarchical enhancer occupancy with independent binding of LEF-1 and CREB. Our data indicate that the formation of a multiprotein complex on the enhancer in vivo is highly cooperative and that no single Eα binding factor can access chromatin in vivo to play a unique initiating role in its assembly. Rather, the simultaneous availability of multiple enhancer binding proteins is required for chromatin disruption and stable binding site occupancy as well as the activation of transcription and V(D)J recombination.
Home Incarceration: An International Alternative to Institutional Incarceration

This work undertakes to examine the potential use of home incarceration as an alternative sentence. Beginning with a theoretical consideration of the purposes of sentencing, it proceeds to an examination of home incarceration in terms of both advantages and disadvantages. Advantages include a good degree of fit with other alternatives, potential for use at various stages of the sentencing process, ease of initiation by either offender or official, reasonable expectation of adoption, and a history of latent use. Problems include both legal questions and administrative issues. Close examination indicates that home incarceration is well worth investigating as a viable sentencing alternative.
A non-flight muscle isoform of Drosophila tropomyosin rescues an indirect flight muscle tropomyosin mutant.

The tropomyosin I(TmI) gene of Drosophila melanogaster encodes two isoforms of tropomyosin. The Ifm-Tml isoform is expressed only in indirect flight and jump muscles; the Scm-TmI isoform is found in other muscles of the larva and adult. The level of Ifm-TmI is severely reduced in the flightless mutant Ifm(3)3, which also is unable to jump. To explore the functional significance of tropomyosin isoform diversity in Drosophila, we have used P element-mediated transformation to express Scm-TmI in the indirect flight and jump muscles of Ifm(3)3 flies. Transformants gained the ability to jump and fly. The mechanical properties of isolated indirect flight muscle myofibres, and the ultrastructure of indirect flight and jump muscles from the transformants were comparable to wildtype. Thus, the Scm-TmI isoform can successfully substitute for Ifm-TmI in the indirect flight and jump muscles of the Ifm(3)3 strain.
Deficiencies in accident record systems

As part of the continuous process of improving highway safety, the engineer relies heavily on information provided by accident record systems. The study described in this paper sought to determine the reliability of this system in New Mexico. Techniques employed in the study included internal consistency checks, comparison with other record systems, and matching actual and reported crash site data. The extent of omitted and inaccurate data having primary relevance to engineering analyses was found to exceed acceptable limits. Incorrect locational information was the most serious problem. The recommended solutions to this problem consist of a modified accident report form and improved contact with enforcement officials.
“The Greatest Crime Syndicate since the Gambinos”: A Hacker Critique of Government, Law, and Law Enforcement

The current study presents a content analysis of articles, editorials, short stories, and book reviews from the widely read and disseminated hacker zine 2600: The Hacker Quarterly, which were examined for author discussions of governments, law, law enforcement, and government officials. A total of five themes were uncovered. The first three themes are part of a hacker critique of governments that describe these institutions as controlling, as incompetent or inadequate, and as creators of collateral damage. Then, exceptions to the hacker critique are presented and their significance assessed. Finally, solutions to the problems the authors discuss are presented.
Progress in Brucella vaccine development

Brucella spp. are zoonotic, facultative intracellular pathogens, which cause animal and human disease. Animal disease results in abortion of fetuses; in humans, it manifests flu-like symptoms with an undulant fever, with osteoarthritis as a common complication of infection. Antibiotic regimens for human brucellosis patients may last several months and are not always completely effective. While there are no vaccines for humans, several licensed live Brucella vaccines are available for use in livestock. The performance of these animal vaccines is dependent upon the host species, dose, and route of immunization. Newly engineered live vaccines, lacking well-defined virulence factors, retain low residual virulence, are highly protective, and may someday replace currently used animal vaccines. These also have possible human applications. Moreover, due to their enhanced safety and efficacy in animal models, subunit vaccines for brucellosis show great promise for their application in livestock and humans. This review summarizes the progress of brucellosis vaccine development and presents an overview of candidate vaccines.
BINDING OF IXR1, A YEAST HMG-DOMAIN PROTEIN, TO CISPLATIN-DNA ADDUCTS IN VITRO AND IN VIVO

Ixr1 is a yeast HMG-domain protein that binds specifically to DNA adducts formed by the antitumor drug cisplatin. Interruption of the IXR1 gene in yeast desensitizes cells to cisplatin. This effect is unrelated to a natural function of Ixr1, which is to repress the transcription of COX5b. Ixr1 interacts specifically and preferentially with DNA modified by cisplatin. In the present work, Ixr1 was purified from a clone expressed in Escherichia coli. The dissociation constant for Ixr1 binding site-specifically to a 92-bp probe containing a single cis-[Pt(NH3)2{d(GpG)-N7(1) -N7(2)}] intrastrand cross-link was measured to be 2.5 (+/- 0.1) x 10(-7) M, similar to that found for HMG1. Ixr1 binds at least an order of magnitude more tightly to cisplatin-DNA adducts than to unmodified DNA. Hydroxyl radical footprinting revealed that Ixr1 protects an area of platinated DNA that is approximately 15 bp in size and centered at the platinum adduct. The binding of HMG-domain proteins to cisplatin-DNA adducts has been proposed to divert these proteins from their natural DNA-binding sites, disrupting transcription. This hypothesis was tested for Ixr1 in yeast. The protein was not titrated away from the Cox5b promoter sufficiently well to disrupt transcription either of Cox5b mRNA from genomic DNA or of the beta-galactosidase gene under control of the promoter in a plasmid DNA transformed into yeast.