cssi/SciSciGPT-SciSciNet huggingface dataset:
Towards Quantum Computing: A Hybrid Approach That Will Unleash a Plethora of New QD Nanostructures, Bringing Us a Step Further to Laterally Coupled QDs.

While the properties of individual quantum dots (QDs) are deemed attractive for applications in quantum computing, practically, they are insufficient. However, being able to group QDs to enable communication among them (quantum dot molecules—QDMs) is still extremely challenging although this field has been studied for about 20 years. Therefore, in an attempt to control the lateral ordering of QDs, researchers at the University of Arkansas have developed a simple hybrid technique to fabricate QD pairs (QDPs) and QDMs. This technique has shown promise and paves the way for investigating possible interactions between QDs, taking us one step further to realizing quantum computing.
Trigger-specific risk factors and response to therapy in long QT syndrome type 2

Background Cardiac events in patients with long QT syndrome type 2 (LQT2) are predominately associated with sudden arousal. However, exercise-induced events also occur in this population. Objective The purpose of this study was to test the hypothesis that risk factors show a trigger-specific association with cardiac events in LQT2 patients. Methods The study population consisted of 634 genetically confirmed LQT2 patients from the U.S. portion of the International LQTS Registry. Multivariate Cox proportional hazards regression analysis was used to determine the independent contribution of clinical and genetic risk factors to the first occurrence of trigger-specific cardiac events, categorized as arousal, exercise-induced, and nonarousal/nonexercise, from birth through age 40 years. Results Study patients experienced 204 cardiac events during follow-up, of which 44% were associated with arousal triggers, 13% with exercise activity, and 43% with nonexercise/nonarousal triggers. Risk factors for arousal-triggered cardiac events included gender (female:male >13 years: hazard ratio [HR] 9.10, P P = .009). In contrast, non–pore-loop transmembrane mutations were the predominant risk factor for exercise-triggered events (HR 6.84, P P Conclusion The study findings suggest that management of patients with the LQT2 genotype should use a trigger-specific approach to risk assessment and medical therapy.
Learning disorders. Some medical aspects.

Gordon, N. (The Royal Manchester Children's Hospital and Booth Hall Children's Hospital, Manchester, England). Learning disorders—some medical aspects. Acta Paediatr Scand, 66:247, 1977.—The first skills are motor ones and these depend on perceptual development and the organisation of movement. If development is deviant the child will be clumsy. The clinical picture is considered, and the effects this may have in the school situation. Disorders of language development may be secondary to other factors such as deafness or brain injury, or may be a specific disability. The various grades of the latter are described. Both perceptual and language disorders can underlie reading retardation and the analysis of a particular child's difficulties is stressed. The etiology of these conditions is discussed with particular reference to the failure of integration. Intracerebral connections may not form, be destroyed, or not used. The role of the Doctor is an important one, and this includes not only diagnosis and assessment but also helping the child in the home and school, especially when emotional and behaviour complications occur. The doctor must also act as a questioner and co-ordinator.
Data Marshaling for Multicore Systems

Dividing a program into segments and executing each segment at the core best suited to run it can improve performance and save power. When consecutive segments run on different cores, accesses to intersegment data incur cache misses. Data Marshaling eliminates such cache misses by identifying and marshaling the necessary intersegment data when a segment is shipped to a remote core.
Performance evaluation of a Pose Estimation method based on the SwissRanger SR4000

This paper presents an experimental study on the performance of a Pose Estimation (PE) method based on a 3D time-of-flight camera — the SwissRanger SR4000. The PE method tracks the visual features in the camera's intensity image and computes the camera's pose change from the 3D data of the matched features. To attain a small PE error, the noises of the sensor's intensity and range data are analyzed and a Gaussian filter is applied to reduce the noises. The statistical property of the filtered data is then characterized and the result is used to determine the minimum number of 3D data points that are required for a satisfactory PE accuracy. Two feature extractors, the SIFT (Scale Invariant Feature Transform) and SURF (Speed Up Robust Features) extractors, are used for the PE method and their performances are compared in term of PE error and computational time. Experimental results with various combinations of rotation and translation movements demonstrate that the SIFT extractor outperforms the SURF extractor in both PE accuracy and repeatability.
Unusual oxidative rearrangement of 1,5-diazadecalin

Abstract Upon treatment with (PhIO)n or PhI(OAc)2, 1,5-diaza-cis-decalin undergoes oxidation at the more hindered position along with fragmentation to yield the ring-expanded bislactam. The cis and trans 1,5-diazadecalins both undergo the same elimination indicating a potential stereoelectronic preference for oxidation at the more substituted carbon alpha to the nitrogen. Oxidation at the less hindered positions of 1,5-diaza-cis-decalin was accomplished on the Boc-protected derivative to provide an intermediate for the synthesis of 2,6-substituted-1,5-diaza-cis-decalins.
Scattering measurements on a low-loss fluorozirconate optical fibre

The scattering loss in a low-loss fluorozirconate fibre has been measured in the infra-red and visible regions using an integrating sphere. At 2.55 ?m, the scattering loss is 1 dB/km including a wavelength-independent offset of 0.6 dB/km. Two bright pinpoints in the fibre were found to contribute a few per cent of the total scattering from the entire fibre. Otherwise, there was found to be little variation in scattering level along the fibre.
Velocity, scalar and transfer spectra in numerical turbulence

Velocity and passive-scalar spectra for turbulent fields generated by a forced three-dimensional simulation with 1283 grid points and Taylor-microscale Reynolds numbers up to 83 are shown to have convective and diffusive spectral regimes. One-and three-dimensional spectra are compared with experiment and theory. If normalized by the Kolmogorov dissipation scales and scalar dissipation, velocity spectra and scalar spectra for given Prandtl numbers collapse to single curves in the dissipation regime with exponential tails. If multiplied by k⅗ the velocity spectra show an anomalously high Kolmogorov constant that is consistent with low Reynolds number experiments. When normalized by the Batchelor scales, the scalar spectra show a universal dissipation regime that is independent of Prandtl numbers from 0.1 to 1.0. The time development of velocity spectra is illustrated by energy-transfer spectra in which distinct pulses propagate to high wavenumbers.
Time series analysis as input for clinical predictive modeling: Modeling cardiac arrest in a pediatric ICU

Background Thousands of children experience cardiac arrest events every year in pediatric intensive care units. Most of these children die. Cardiac arrest prediction tools are used as part of medical emergency team evaluations to identify patients in standard hospital beds that are at high risk for cardiac arrest. There are no models to predict cardiac arrest in pediatric intensive care units though, where the risk of an arrest is 10 times higher than for standard hospital beds. Current tools are based on a multivariable approach that does not characterize deterioration, which often precedes cardiac arrests. Characterizing deterioration requires a time series approach. The purpose of this study is to propose a method that will allow for time series data to be used in clinical prediction models. Successful implementation of these methods has the potential to bring arrest prediction to the pediatric intensive care environment, possibly allowing for interventions that can save lives and prevent disabilities.
A Monte Carlo simulation environment for wear out in VLSI systems

The authors describe a simulation environment for reliability prediction of VLSI designs. Specifically, the effect of electromigration on the time-to-failure is investigated. The capabilities of the environment are illustrated with a case study of a microprocessor intended for control applications. The system under investigation is first simulated at the switch level and trace data on the switching activity is collected. This data is then used along with Monte Carlo simulation to model wear-out at the chip-level. >
Replication, lies and lesser‐known truths regarding experimental design in environmental microbiology

A recent analysis revealed that most environmental microbiologists neglect replication in their science (Prosser, 2010). Of all peer-reviewed papers published during 2009 in the field's leading journals, slightly more than 70% lacked replication when it came to analyzing microbial community data. The paucity of replication is viewed as an 'endemic' and 'embarrassing' problem that amounts to 'bad science', or worse yet, as the title suggests, lying (Prosser, 2010). Although replication is an important component of experimental design, it is possible to do good science without replication. There are various quantitative techniques - some old, some new - that, when used properly, will allow environmental microbiologists to make strong statistical conclusions from experimental and comparative data. Here, I provide examples where unreplicated data can be used to test hypotheses and yield novel information in a statistically robust manner.
Poster: A neighbor-weighted K-nearest neighbor method for predicting protein subnuclear localizations

In this study, we have developed a neighbor-weighted K-nearest neighbor (K-NN) method for predicting subnuclear localizations of proteins.
A dependent pathway of gene functions leading to chromosome segregation in Saccharomyces cerevisiae

Methyl-benzimidazole-2-ylcarbamate (MBC) inhibits the mitotic cell cycle of Saccharomyces cerevisiae at a stage subsequent to DNA synthesis and before the completion of nuclear division (Quinlan, R. A., C. I. Pogson, and K, Gull, 1980, J Cell Sci., 46: 341-352). The step in the cell cycle that is sensitive to MBC inhibition was ordered to reciprocal shift experiments with respect to the step catalyzed by cdc gene products. Execution of the CDC7 step is required for the initiation of DNA synthesis and for completion of the MBC-sensitive step. Results obtained with mutants (cdc2, 6, 8, 9, and 21) defective in DNA replication and with an inhibitor of DNA replication (hydroxyurea) suggest that some DNA replication required for execution of the MBC-sensitive step but that the completion of replication is not. Of particular interest were mutants (cdc5, 13, 14, 15, 16, 17, and 23) that arrest cell division after DNA replication but before nuclear division since previous experiments had not been able to resolve the pathway of events in this part of the cell cycle. Execution of the CDC17 step was found to be a prerequisite for execution of the MBC-sensitive step; the CDC13, 16 and 23 steps are executed independently of the MBC-sensitive step; execution of the MBC-sensitive step is prerequisite for execution of the MBC-sensitive step; execution of the MBC-sensitive step is prerequisite for execution of the CDC14 and 23 steps. These results considerably extend the dependent pathway of events that constitute the cell cycle of S. cerevisiae.
Heterotopic ossification after hemiarthroplasty of the hip - A comparison of three common approaches.

Abstract Objective Heterotopic ossification (HO) about the hip after total hip arthroplasty and internal fixation of the hip, pelvis, and acetabulum has been linked to surgical approach. However, no study has investigated surgical approach and HO in patients undergoing hemiarthroplasty. We therefore aimed to explore the influence of operative approach in patients undergoing hemiarthroplasty. Methods Through a retrospective case series at an Urban level I trauma center, we found 80 patients over the age of 60 undergoing hemiarthroplasty for femoral neck fractures from 2000 to 2009. Patient charts, operative notes, and radiographs were reviewed for demographics, operative approach (anterior: A, anterior-lateral: AL, posterior: P), and any development of HO. Fisher's exact test compared rates of HO among the three approaches. Student's t-tests compared Brooker Classification levels of HO among the approaches. Results 82 hemiarthroplasties (26 A, 32 AL, 24 P) were included for analysis. 22 patients (27%) had HO. There was no significant difference in the development of HO based upon surgical approach: A: 19% (n = 5); AL: 34% (n = 11); P: 25% (n = 6). There was a significant difference in the grade of HO based on Brooker Classification (BC) with the posterior approach resulting in significantly lower grade of HO: A (BC: 2.60); AL (BC: 2.64); P (BC: 1.50) (p = 0.012). Conclusions Our data is the first to evaluate surgical approach and HO in patients with hemiarthroplasty. Patients have a significant risk of developing higher grade HO based on surgical approach (A or AL). Orthopedists should be mindful of these risks when considering A or AL approaches.
Skeletal muscle phosphocreatine depletion depresses myocellular energy status during sepsis.

Objective: To determine the effects of phosphocreatine (PCr) depletion on myocellular energetics. Design: Randomized controlled study. Setting: University laboratory. Materials: Thirty-eight adult male Wistar rats (110-121 g). Methods: The poorly metabolized creatine analogue β-guanidinopropionic acid, (β-GPA, 2% of a gel diet) was fed to the rats for 14 days to replace (75%) endogenous PCr stores before cecal ligation and puncture (CLP). Rats were randomized to receive sham operation and gel diet (sham-gel group [n= 10]), sham operation and β-GPA diet (sham-β-GPA group [n = 9]), CLP and gel diet (CLP-gel group [n = 10]), and CLP and β-GPA diet (CLP-β-GPA group [n=9]). On day 14, all animals underwent operation. Twenty-four hours later, in vivo phosphorus 31-labeled magnetic resonance spectroscopy ( 31 P-MRS) of the gastrocnemius muscle was performed. Muscle samples were collected to determine enzyme activities of β-hydroxyacyl-CoA dehydrogenase, phosphofructokinase, citrate synthase, and the metabolites adenosine triphosphate (ATP), PCr, inorganic phosphate, and creatine. Free adenosine diphosphate levels, the phosphorylation potential, and free energy change of ATP hydrolysis were then calculated. Results: All animals undergoing CLP but no controls had positive results of blood cultures. Although sham-β-GPA animals had altered bioenergetics, CLP-β-GPA rats experienced a greater deterioration of energy state compared with CLP-gel controls. Glycolytic and oxidative enzyme activities were not significantly different between groups and therefore could not explain the observed differences. Conclusions: There is an overall decrease in energy availability during sepsis, which is worsened by PCr depletion. These changes support the contention that PCr plays an important role as an ATP buffer during systemic infection.
An association between snowfall and ED presentation of cardiac arrest

Studies from several cities have reported increased cardiovascular mortality associated with snowfall; whether this weather also results in increased emergency department (ED) presentation of cardiac arrests is not known. A retrospective review was conducted of cardiac arrest patients presenting to a New England ED during the months of October through May, from 1991 to 1994. Comparing daily frequency of cardiac arrest patients with climactic data, a 27% increase was observed in the frequency of cardiac arrest presentation to the ED on days with snowfall (P = .0004). ED physicians and staff should anticipate an increased frequency of cardiac arrest patients on days with snowfall.
Symbolic integration of dynamical systems by collocation methods

Symbolic computational approaches are desirable for many applications and especially for large complex and nonlinear systems. These approaches work well when (a) the user interface is "symbolized" and (b) the underlying computational algorithms are robust. This paper presents advances in both of these areas and for the specific application of numerical integration of large complex nonlinear systems. We present a method for symbolically defining complex nonlinear systems. The methodology includes a human interface for symbolic manipulations of the system model. The system model is symbolically quadratized. The quadratized model is integrated with a numerical method that belongs to the general class of collocating methods. The presented methodologies are superior to previous approaches by the authors using symbolic manipulations and trapezoidal integration. The methodology is illustrated with example systems including converters with saturable inductors, surge arresters and other complex nonlinear systems. The proposed methodology is compared to previous approaches for the purpose of quantifying the advantages.
Energetics and stability of transmembrane helix packing : A replica-exchange simulation with a knowledge-based membrane potential

The energetics and stability of the packing of transmembrane helices were investigated by Monte Carlo simulations with the replica-exchange method. The helices were modeled with a united atom representation, and the CHARMM19 force field was employed. Based on known experimental structures of membrane proteins, an implicit knowledge-based potential was developed to describe the helix-membrane interactions at the residue level, whose validity was tested through prediction of the orientations when single helices were inserted into a membrane. Two systems were studied in this article, namely the glycophorin A dimer, and helices A and B of Bacteriorhodopsin. For the glycophorin A dimer, the most stable structure (0.5 A away from the experimental structure) is mainly stabilized by the favorable helix-helix interactions, and has the most population regardless of the helix-membrane interaction. However, for helices A and B of Bacteriorhodopsin, it was found that the packing determined by helix-helix interactions is nonspecific, and a native-like structure (0.2 A from the experimental one) can be identified from several structural analogs as the most stable one only after applying the membrane potential. Our results suggest that the contribution from the helix-membrane interaction could be critical in the correct packing of transmembrane helices in the membrane.
Analysis of cellulolytic and hemicellulolytic enzyme activity within the Tipula abdominalis (Diptera: Tipulidae) larval gut and characterization of Crocebacterium ilecola gen. nov., sp. nov., isolated from the Tipula abdominalis larval hindgut.

In forested stream ecosystems of the north and eastern United States, larvae of the aquatic crane fly Tipula abdominalis are important shredders of leaf litter detritus. T. abdominalis larvae harbor a dense and diverse microbial community in their hindgut that may aide in the degradation of lignocellulose. In this study, the activities of cellulolytic and hemicellulolytic enzymes were demonstrated from hindgut extracts and from bacterial isolatesusingmodelsugarsubstrates.Oneofthebacterialisolateswasfurthercharacterized as a member of the family Microbacteriaceae. Taxonomic position of the isolate within this family was determined by a polyphasic approach, as is commonly employed for the separation of genera within the family Microbacteriaceae. The bacterial isolate is Gram- type positive, motile, non-sporulating, and rod-shaped. The G + C content of the DNA is 64.9 mol%. The cell wall contains B2γ type peptidoglycan, D- and L-diaminobutyric acid as the diamino acid, and rhamnose as the predominant sugar. The predominant fatty acids are 12-methyltetradecanoic acid (ai-C15:0) and 14-methylhexadecanoic acid (ai-C17:0). The isolate forms a distinct lineage within the family Microbacteriaceae, as determined by 16S rRNA sequence analysis. We propose the name Crocebacterium ilecola gen. nov., sp. nov., to accommodate this bacterial isolate. The type species is T202 T (ATCC BAA-1359; GenBank Accession DQ826511).
Evidence and the Practice of Prosthodontics: 20 Years after EBD Introduction

Prosthodontics has a rich history related to the principles embedded in evidence-based health care. This paper reviews the evidence-based prosthodontics activity over the past 3 decades. It also discusses the impact of health care reform on evidence-based medicine as it relates to broader context of care outcomes. Finally, the value associated with an Evidence Stewardship emphasis in prosthodontics is presented. This emphasis suggests that combining evidence from clinical trials with evidence from clinical practice environments best equips clinicians for the management of patients in the future. Adoption of a strategic Evidence Stewardship direction is an extended commitment to change that recognizes health care reform aims and seeks to be an accountable provider group in the broader health care arena. The vision to form a representative network of prosthodontic practitioners that augments a commitment to Cochrane "clinical trial" data demonstrates a responsibility to professional transparency about who we are, adds value for patients and oral health care providers, impacts teachers and students in dental education, and provides a measure of care accountability unique in dentistry.
Guard cell zeaxanthin tracks photosynthetically active radiation and stomatal apertures in Vicia faba leaves

Zeaxanthin, antheraxanthin and violaxanthin concentrations in guard cells from sonicated abaxial epidermal peels of Viciafaba were measured from dawn to dusk, and compared with concentrations in mesophyll tissue of the same leaves. Measured changes in guard cell zeaxanthin and violaxanthin concentrations indicate that guard cells operate the xanthophyll cycle throughout the day. Mesophyll tissue had no detectable zeaxanthin at dawn, whereas guard cells had 30-50 mmol mol -1 chlorophyll a+b. On a chlorophyll basis, maximal zeaxanthin levels were 3-4 fold higher in guard cells than in mesophyll cells. Zeaxanthin concentrations tracked levels of photosynthetically active radiation (PAR) in both mesophyll and guard cells. In the mesophyll, most of the zeaxanthin changes occurred in mid-morning and mid-afternoon. In guard cells, zeaxanthin concentrations changed nearly linearly with PAR in the early morning and late afternoon, and closely tracked PAR levels throughout the day. Guard cell zeaxanthin concentrations were also closely correlated with stomatal apertures. The close relationship between zeaxanthin concentrations and PAR levels in guard cells indicates that zeaxanthin is well suited to function as a molecular photosensor in stomatal movements.
Conditional Induction of Ovulation in Mice

Follicle-stimulating hormone controls the maturation of mammalian ovarian follicles. In excess, it can increase ovulation (egg production). Reported here is a transgenic doxycycline-activated switch, tested in mice, that produced more FSHB subunit (therefore more FSH) and increased ovulation by the simple feeding of doxycycline (Dox). The transgenic switch was expressed selectively in pituitary gonadotropes and was designed to enhance normal expression of FSH when exposed to Dox, but to be regulated by all the hormones that normally control FSH production in vivo. Feeding maximally effective levels of Dox increased overall mRNA for FSHB and serum FSH by over half in males, and Dox treatment more than doubled the normal ovulation rate of female mice for up to 10 reproductive cycles. Lower levels of Dox increased the number of developing embryos by 30%. Ovarian structure and function appeared normal. In summary, gene switch technology and normal FSH regulation were combined to effectively enhance ovulation in mice. Theoretically, the same strategy can be used with any genetic switch to increase ovulation (or any highly conserved physiology) in any mammal.
Robot-directed speech: using language to assess first-time users' conceptualizations of a robot

It is expected that in the near-future people will have daily natural language interactions with robots. However, we know very little about how users feel they should talk to robots, especially users who have never before interacted with a robot. The present study evaluated first-time users' expectations about a robot's cognitive and communicative capabilities by comparing robot-directed speech to the way in which participants talked to a human partner. The results indicate that participants spoke more loudly, raised their pitch, and hyperarticulated their messages when they spoke to the robot, suggesting that they viewed the robot as having low linguistic competence. However, utterances show that speakers often assumed that the robot had humanlike cognitive capabilities. The results suggest that while first-time users were concerned with the fragility of the robot's speech recognition system, they believed that the robot had extremely strong information processing capabilities.
Localization of Cell-bound Penicillinase in Bacillus licheniformis

Abstract When protoplasts are prepared from Bacillus licheniformis (strain 749/C, constitutive for penicillinase), approximately 60% of the cell-bound penicillinase is released. The remainder is retained by the protoplast and cannot be removed by washing. This release is specific, in that less than 7% of the cellular reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase and α-glucosidase is liberated by the treatment. The freed penicillinase is excluded from G-200 Sephadex, and it is partially sedimented with a force of 65,000 × g for 20 hr. It is probably attached to characteristic tubular and vesicular structures with single-layered membranes that are comparable to structures previously described in intact penicillinase-forming cells. The specific activity of the organelle is more than six times that of twice washed peripheral membrane; furthermore, about 8% of the protein of the structure is penicillinase. At substrate concentrations (benzylpenicillin) of about one-fifth the Km value, whole cells show a slight permeability restriction, although this does not occur in isolated particles and protoplasts.
Estimating Reference Evapotranspiration with Minimum Data in Florida

Reference evapotranspiration estimation methods that require minimal data are necessary when climatic data sets are incomplete, inaccurate, or unavailable. This study was conducted to evaluate temp...
Effects of exchanged cation on the microporosity of montmorillonite

The micropore volumes of 2 montmorillonites (SAz-1 and SWy-1), each exchanged with Ca, Na, K, Cs and tetramethylammonium (TMA) ions, were calculated from the measured vapor adsorption data of N 2 and neo-hexane by use of t- and a~-plots. The corresponding surface areas of the exchanged clays were determined from Brunauer-Emmett-Teller (BET) plots of N 2 adsorption data. Micropore vol- umes and surface areas of the samples increased with the size of exchanged cation: TMA > Cs > K > Ca > Na. The SAz-1 exchanged clays showed generally greater micropore volumes and surface areas than the corresponding SWy-1 clays. The vapor adsorption data and d(001) measurements for dry clay samples were used together to evaluate the likely locations and accessibility of clay micropores, especially the relative accessibility of their interlayer spacing. For both source clays exchanged with Na, Ca and K ions, the interlayer spacing appeared to be too small to admit nonpolar gases and the accessible micropores appeared to have dimensions greater than 5.0 .~, the limiting molecular dimension of neo-hexane. In these systems, there was a good consistency of micropore volumes detected by N2 and neo-hexane. When the clays were intercalated with relatively large cations (TMA and possibly Cs), the large layer expansion created additional microporosity, which was more readily accessible to small N: than to relatively large neo-hexane. Hence, the micropore volume as detected by N 2 was greater than that detected by neo-hexane. The micropore volumes with pore dimensions greater than 5 A determined for clays exchanged with Na, Ca and K likely resulted from the pores on particle edges and void created by overlap regions of layers. The increase in micropore volumes with pore dimensions less than 5 A determined for clays exchanged with TMA and possibly Cs could be caused by opening of the interlayer region by the intercalation of these large cations.
Numeric databases on the kinetics of transient species in solution

Abstract A description is given of data compilations on the kinetics of transient species in solution. In particular information is available for the reactions of radicals in aqueous solution and for excited states such as singlet molecular oxygen and those of metal complexes in solution. Methods for compilation and use of the information in computer-readable form are also described. Emphasis is placed on making the database available for online searching.
Modeling the Response of Paved Low-Volume Roads Under Various Traffic and Seasonal Conditions

Since low-volume road (LVR) systems were first designed and built, events such as deregulation and free-trade agreements and changes in economic growth patterns and in manufacturing and farming practices have resulted in increased truck movements and have accelerated the deterioration of paved LVRs, such as the ones in North Dakota, which were not designed for such heavy-truck traffic. The traditional empirical methods—use of the soil factor and R-value designs and the use of visual inspection and ride quality—to assess pavement performance are not adequate. A mechanistic model that uses material data and is capable of predicting pavement response under different traffic loading and seasonal conditions is deemed necessary. An analytical approach to determine and compare pavement response for different truck axle loadings under normal, thaw, and hot summer seasonal conditions on paved LVRs is discussed. A three-dimensional finite element program is used to model the pavement response in the form of total p...
Some reflections on my career, publishing, and contributing significantly to a field

En el presente articulo, el autor ofrece una perspectiva general de sus mas de tres decadas de trayectoria academica y hace un analisis retrospectivo de su evolucion como investigador. Siguiendo esa perspectiva y bajo un analisis amplio, el autor resena sus 15 anos de investigacion colaborativa sobre la calidad del servicio (con sus colegas Valarie Zeithaml y Len Berry), con el fin de ilustrar la naturaleza de una corriente de investigacion programatica sobre un tema importante y el impacto significativo que esa forma de investigar puede tener en la base y en la practica del conocimiento de una disciplina. El autor tambien menciona un numero de experiencias personales que surgen de la reflexion sobre su carrera como investigador, y discute las repercusiones que estas experiencias podrian tener para otros investigadores. El articulo concluye con algunas observaciones y recomendaciones generales sobre como se puede contribuir significativamente a un campo del conocimiento.
Low NOx heavy fuel oil combustion with high temperature air

For an industrial-scale test furnace, the development and investigation of a heavy-oil-fired burner in a highly preheated air combustion system are discussed. The 1200 °C highly preheated combustion air was achieved by burners equipped with regenerators in high-cycle reciprocal firing. It was observed that the high-cycle reciprocal firing enhanced convective heat transfer to the furnace wall. Reduction of nitric oxide emissions was achieved by fuel directly injected into furnace (F2 mode) and mixed with combustion products. In previous studies of natural gas combustion in reciprocal firing, two injectors located at the burner quarl have been utilized to achieve low nitric oxide combustion. In this study, reduction of nitric oxide was investigated using single or paired atomizers located in the upper and lower position of burner quarl. It was found that buoyant forces were important for the mixing of fuel oil with high temperature air and for the resultant nitric oxide emission. Nitric oxide emission was found to be low with the paired atomizers in the F2 firing mode. Nitric oxide emission can be further reduced by use of a single atomizer rather than using paired atomizers.
The No-Care Zone: Availability, Accessibility, and Acceptability in Community-Based Long-Term Care

Community-based care for chronic illness requires a continuum of services. This article identifies three aspects of the organization of long-term care that are important in maintaining a continuum: availability, accessibility, and acceptability. Each category is illustrated by data from Missouri to demonstrate potential problems in each of the three areas that can prevent the chronically ill from obtaining needed services.
Bit and Power Allocation Strategies for OFDM Systems over Time-Varying Channels

Many bit and power allocation algorithms have been recently developed for OFDM systems assuming perfect knowledge of the channel state information (CSI). In practice, however, these algorithms experience significant performance loss due to the inaccuracies in CSI. For time-varying channels the imperfect channel state information due to outdated channel estimates is a major source of these inaccuracies. To mitigate this effect, we propose to predict the channel state information and devise the bit and power allocation algorithm using the predicted CSI. We study several channel prediction algorithms for OFDM systems and present robust bit and power allocation schemes based on the predicted CSI. Simulation results show that for Doppler frequencies up to 100Hz, the proposed bit and power allocation algorithms (using the predicted CSI) can achieve performance close to that of the algorithms that assume perfect knowledge of CSI.
High-Speed Modulation of Index-Guided Implant-Confined Vertical-Cavity Surface-Emitting Lasers

An etched photonic crystal (PhC) or holey wedge structure induces index confinement into 850-nm implant-confined vertical-cavity surface-emitting lasers (VCSELs) to engineer the spatial overlap between the optical mode and laser gain for improved high-speed operation and reduced relative intensity noise. Large-signal operation of 12.5 Gb/s is achieved with a single transverse-mode PhC VCSEL and 15 Gb/s with a single transverse-mode holey VCSEL. An excessive current diffusion effect is found when the difference between the electrical and optical diameter is large (>4 mum), which limits the large-signal modulation of single-mode VCSELs. The design rules for optimal single transverse-mode high-speed PhC and holey VCSELs are extracted from a parametric study of their large-signal modulation characteristics.
Pre-clinical activity of BET protein antagonist-based combinations against ibrutinib-sensitive or -resistant human Mantle Cell Lymphoma cells

S64 analyses have been conducted to help guide treatment of this disease. These suggest that DA EPOCH-R may be the most promising regimen. Conclusion: Our patient was started on DA EPOCH-R, her lesions have essentially resolved and PET/CT after the second (of six) cycle demonstrated a CR. Early CR predicts better outcomes in DLBCL, and unclear but hopefully applies to DHL.
The observation of the curative effect and safety about tripterygium wilfordii glucoside piece and loratadine on the treatment of chronic idiopathic urticaria

Objective To analyse the curative effect and safety about tripterygium wilfordii glucoside piece and loratadine on the treatment of chronic idiopathic urticaria. Methods 100 patients with CIU were included in the study,patients in research groupwere treatedwith tripterygium wilfordii glucoside piece and loratadine,whereas the control groupwere treatedwith loratadine only,50 cases in each group. Compared the clinical curative effect at the 2nd and 4thweek after treatment,and follow-up for 3 months to observe the condition of palindromiaand the clinical safety. Results The total effective rate of the research group and control groupwere82. 0% and 60. 0% at the 2ndweek after the treatment; Total effective rate of the research group and control group were92. 0% and 68. 0% at the 4th week after the treatment. The palindromia rate of the research group and control group were 8. 0% and 26. 0% after follow-up for 3 months. The incidence of adverse effect of research group and control group were 8. 0% and 6. 0% separately. Get together,the research group present better curative effect and more safty( P 0. 05). Conclusions The application of tripterygium wilfordii glucoside piece combined with loratadine present significant curative effect and high safety on the treatment of CIU,and worth promoting.
Activities of and time spent by the project dietitian in implementing a custom-designed decision support system for a computer.

Abstract Part 1 of this study involved development and implementation of a prototype of Interactive Foodservice Decision Assist Methods (IFDAM) software. A 1-day menu from the Health Center of Methodist Health Services, Inc., which included 161 menu items and 181 ingredients, composed the data base. The prototype was used to test transfer procedures from the mainframe computer at the university to the one at the hospital and to test the program and train users. Three supporting documents were written. The Procedure Manual described methodology for data collection and use of IFDAM at the Health Center. The Data-Entry Manual explained the use of the microcomputer for entering information into IFDAM. The User Manual illustrated the command structure of IFDAM. Part 2 of the study included the addition of data from five cost centers, which were serviced from the central production facility of the Health Center. Six-week-cycle menus and all ingredient files in the food service were incorporated into the data base. The data totaled 998 menu items and 660 ingredients. Time spent by the project dietitian on development of data bases and support manuals, completion of data forms, data entry and transfer, conferences, and training totaled 362.10 hours and 898.75 hours in Parts 1 and 2, respectively. The project required 30 months to complete. Problems classified as equipment, program, or personnel, delayed implementation. J Am Diet Assoc 88:200, 1988.
TU-AB-202-04: Development of a DeformableImage Registration (DIR) Error Correction Method Employing Kolmogorov-Zurbenko(KZ) Filter

Purpose: This study aims to develop a DIR error correction method capable of utilizing sparse ground-truth motion information and recovering missing data with the Kolmogorov-Zurbenko (KZ) filter. Methods: The error correction method employs a two-step approach. First, sparse ground-truth displacement vectors are integrated into a pre-correction deformable vector field (DVF) to estimate a post-correction DVF with coarse resolution. Second, the coarse post-correction DVF is boosted to a full-resolution DVF through convolution with the KZ filter. To validate the use of the KZ filter for missing data recovery, recovery errors were determined by comparing a DVF recovered from down-sampling with the original full-resolution DVF. The entire error correction method was tested on an in-house developed digital lung motion phantom consisting of a primary volume, a DVF, and a secondary volume synthesized by applying the DVF on the primary volume. Five pre-correction DVFs were obtained by performing DIR between the two volumes using Velocity, MIM, ILK and OHS algorithms in DIRART toolbox, and Elastix, and then corrected. Primary volumes were synthesized with pre- and post-correction DVFs, respectively. The error correction method was evaluated with pre- and post-correction registration errors, and intensity errors in synthesized primary volumes. Results: Our test results for sparsely down-sampled (<0.4%) DVFs showed that the KZ filter outperformed the cubic polynomial interpolation method for whole lung DVF map recovery in terms of median error (0.60mm vs 0.73mm) and mean error (1.18mm vs 1.29mm). Pre- and post-correction 3D registration errors per voxel for Velocity, MIM, ILK, OHS, and Elastix are reduced by 2.39 mm on average. Pre- and post-correction intensity errors are reduced by 0.37 in unit of image intensity on average. Conclusion: We have implemented a two-step method capable of utilizing sparse ground-truth displacement vectors for DIR error reduction, allowing DIR accuracy improvement utilizing clinically available motion data. This study is supported by NIH grant 1R21CA165384.
Effect of time, temperature, and peptic activity on intrinsic factor content of acid gastric juice.

The effect of time and temperature on the intrinsic factor (IF) activity of acid in native human gastric juice was investigated using a standardized radioimmunoassay. The following observations were made on the loss of IF activity: at body temperature, the loss was very rapid over a period of 4 hr; at room temperature, the loss occurred at a much slower rate over a 7-day period; at + 1 C the loss was almost imperceptible over a week’s time; at − 20 C the deterioration was relatively rapid and led to an almost total loss in only 7 days; and at − 70 C, after an initial fall, no further deterioration occurred for the next 6 days. The initial loss at − 70 C could be minimized by rapid freezing and thawing of the gastric juice. When acid gastric juice was depepsinized, reacidified to its original pH value, and kept at body temperature, practically no loss of IF activity occurred over a 4-hr period. Thus the loss of IF at body temperature would seem to be caused by the peptic activity. Depepsinized, reacidified gastric juice stored at − 20 C showed only a minor loss of IF activity over several days. Therefore, the relatively rapid loss of IF activity when native acid gastric juice is stored at − 20 C would seem to be due mainly to the peptic activity.
Recursive Exercises to Help Students Engage and Recognize Sociological Shifts.

Introductory sociology courses encourage students to shift from understanding social relations and inequalities through an individualistic lens toward a more sociological one. It is difficult for s...
Bacterial genome engineering and synthetic biology: combating pathogens.

Background The emergence and prevalence of multidrug resistant (MDR) pathogenic bacteria poses a serious threat to human and animal health globally. Nosocomial infections and common ailments such as pneumonia, wound, urinary tract, and bloodstream infections are becoming more challenging to treat due to the rapid spread of MDR pathogenic bacteria. According to recent reports by the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC), there is an unprecedented increase in the occurrence of MDR infections worldwide. The rise in these infections has generated an economic strain worldwide, prompting the WHO to endorse a global action plan to improve awareness and understanding of antimicrobial resistance. This health crisis necessitates an immediate action to target the underlying mechanisms of drug resistance in bacteria.
Dynamical analysis of recurrent neural circuits in articulated limb controllers for tool use

Recurrent neural networks (RNNs) often show very complicated temporal behavior. In this paper, we investigate the dynamics of a simple recurrent neural network used in a nontrivial articulated limb control task in a tool use domain. The RNN for the task is evolved by the NeuroEvolution of Augmenting Topologies (NEAT) algorithm. As a non-linear dynamical system, RNNs exhibit strong correlation between their external behavior and internal dynamics. Discovery of the fixed points and limit cycles in the system dynamics will help us understand the roles of neurons and connections in the neural network, and provide insights on how to analyze the function of biology-based nervous systems. We hope our results can provide new criteria to the evaluation of the evolved RNNs, and help the diagnosis of the failures in control problems using neuroevolution.
Multidisciplinary In Situ Simulation-Based Training as a Postpartum Hemorrhage Quality Improvement Project.

ABSTRACT Background: Postpartum hemorrhage is a common obstetric emergency affecting 3 to 5% of deliveries, with significant maternal morbidity and mortality. Effective management of postpartum hemorrhage requires strong teamwork and collaboration. We completed a multidisciplinary in situ postpartum hemorrhage simulation training exercise with structured team debriefing to evaluate hospital protocols, team performance, operational readiness, and real-time identification of system improvements. Our objective was to assess participant comfort with managing obstetric hemorrhage following our multidisciplinary in situ simulation training exercise. Methods: This was a quality improvement project that utilized a comprehensive multidisciplinary in situ postpartum hemorrhage simulation exercise. Participants from the Departments of Obstetrics and Gynecology, Anesthesia, Nursing, Pediatrics, and Transfusion Services completed the training exercise in 16 scenarios run over 2 days. The intervention was a high fideli...
Light Sensing of a-Si:H p-i-n DiodeMechanism of Asymmetric Charge Carrier Transfer

The mechanism of asymmetric carrier transfers on the light sensing of the a-Si:H p-i-n diode has been explored using devices of different i -layer thicknesses illuminated with lights of three different wavelengths, as well as the electric-optical stress method. The location of the photo-generated electron-hole pairs within the I -layer varies with the wavelength of the illuminated light, which contributes to the asymmetric transfer and loss of the carriers. Therefore, the performance of the a-Si:H p-i-n photodiode is a complicated function of the wavelength and defects in the structure.
Top–Down Bayesian Inference of Indoor Scenes

The task of inferring the 3D layout of indoor scenes from images has seen many recent advancements. Understanding the basic 3D geometry of these environments is important for higher level applications, such as object recognition and robot navigation. In this chapter, we present our Bayesian generative model for understanding indoor environments. We model the 3D geometry of a room and the objects within it with non-overlapping 3D boxes, which provide approximations for both the room boundary and objects like tables and beds. We separately model the imaging process (camera parameters), and an image likelihood, thus providing a complete, generative statistical model for image data. A key feature of this work is using prior information and constraints on the 3D geometry of the scene elements, which addresses ambiguities in the imaging process in a top–down fashion. We also describe and relate this work to other state-of-the-art approaches, and discuss techniques that have become standard in this field, such as estimating the camera pose from a triplet of vanishing points.