cssi/SciSciGPT-SciSciNet huggingface dataset:
Expression and Regulation of Endothelial Nitric Oxide Synthase

Abstract Endothelium-derived nitric oxide (NO) is a key determinant of blood pressure homeostasis and platelet aggregation and is synthesized by the endothelial isoform of nitric oxide synthase (eNOS). In the vascular wall, eNOS is activated by diverse cell-surface receptors and by increases in blood flow, and the consequent generation of NO leads to vascular smooth-muscle relaxation. Endothelium-dependent vasorelaxation is deranged in a variety of disease states, including hypertension, diabetes, and atherosclerosis, but the roles of eNOS in endothelial dysfunction remain to be clearly defined. The past several years have witnessed important advances in understanding the molecular and cellular biology of eNOS regulation. In endothelial cells, eNOS undergoes a complex series of covalent modifications, including myristoylation, palmitoylation, and phosphorylation. Palmitoylation of eNOS dynamically targets the enzyme to distinct domains of the endothelial plasma membrane termed caveolae; caveolae may serve as sites for the sequestration of signal-transducing proteins and are themselves subject to dynamic regulation by ligands and lipids. Originally thought to be expressed only in endothelial cells, eNOS is now known to be expressed in a variety of tissues, including blood platelets, cardiac myocytes, and brain hippocampus. Paradigms established in endothelial cells for the molecular regulation and subcellular targeting of eNOS are being extended to the investigation of eNOS expressed in nonendothelial tissues. This review summarizes recent advances in understanding the molecular regulation of eNOS and the other NOS isoforms and identifies important parallels between eNOS and other cell-signaling molecules. © 1997, Elsevier Science Inc. (Trends Cardiovasc Med 1997;7:28–37).
cAMP-activated apical membrane chloride channels in Necturus gallbladder epithelium. Conductance, selectivity, and block

Elevation of intracellular cAMP levels in Necturus gallbladder epithelium (NGB) induces an apical membrane Cl- conductance (GaCl). Its characteristics (i.e., magnitude, anion selectivity, and block) were studied with intracellular microelectrode techniques. Under control conditions, the apical membrane conductance (Ga) was 0.17 mS.cm-2, primarily ascribable to GaK. With elevation of cell cAMP to maximum levels, Ga increased to 6.7 mS.cm-2 and became anion selective, with the permeability sequence SCN- > NO3- > I- > Br- > Cl- >> SO4(2-) approximately gluconate approximately cyclamate. GaCl was not affected by the putative Cl- channel blockers Cu2+, DIDS, DNDS, DPC, furosemide, IAA-94, MK-196, NPPB, SITS, verapamil, and glibenclamide. To characterize the cAMP-activated Cl- channels, patch-clamp studies were conducted on the apical membrane of enzyme-treated gallbladders or on dissociated cells from tissues exposed to both theophylline and forskolin. Two kinds of Cl- channels were found. With approximately 100 mM Cl- in both bath and pipette, the most frequent channel had a linear current-voltage relationship with a slope conductance of approximately 10 pS. The less frequent channel was outward rectifying with slope conductances of approximately 10 and 20 pS at -40 and 40 mV, respectively. The Cl- channels colocalized with apical maxi-K+ channels in 70% of the patches. The open probability (Po) of both kinds of Cl- channels was variable from patch to patch (0.3 on average) and insensitive to [Ca2+], membrane voltage, and pH. The channel density (approximately 0.3/patch) was one to two orders of magnitude less than that required to account for GaCl. However, addition of 250 U/ml protein kinase A plus 1 mM ATP to the cytosolic side of excised patches increased the density of the linear 10-pS Cl- channels more than 10-fold to four per patch and the mean Po to 0.5, close to expectations from GaCl. The permeability sequence and blocker insensitivity of the PKA-activated channels were identical to those of the apical membrane. These data strongly suggest that 10-pS Cl- channels are responsible for the cAMP-induced increase in apical membrane conductance of NGB epithelium.
The effects of food deprivation of rats on swimming to exhaustion.

Male Wistar rats were deprived of food for 3 days and then forced to swim continuously to a criterion of exhaustion. Controls swam after ad libitum feeding. In the first experiment a load equal to 11% of the rat's body weight was attached to the dorsal skin near the tail during the swim. In a second study, two matched groups, treated identically as those in the first study swam without a load in water treated with a wetting agent, "Aerosol O.T." In a third experiment, controls as well as experimentals were deprived of food for three days. The control group, however, was fed for 30 minutes, immediately before the swim. A fourth experiment was conducted in a similar manner as the third, except both groups were deprived 6 hours. In each of the experiments the deprived groups swam significantly longer than the fed groups.
Poor Positive Accuracy of QuickVue Rapid Antigen Tests during the Influenza A (H1N1) 2009 Pandemic

We assessed the accuracy of positive QuickVue rapid influenza virus antigen test results. Using reverse transcription (RT)-PCR as the gold standard, 17 (37.8%) of 45 QuickVue-positive specimens were determined to be false positives. We report an unexpectedly high rate of false-positive QuickVue results during a period of high influenza A (H1N1) 2009 virus prevalence.
Dismantling Promoter-driven RNA Polymerase II Transcription Complexes in Vitro by the Termination Factor Rat1

Proper RNA polymerase II (Pol II) transcription termination is essential to generate stable transcripts, to prevent interference at downstream loci, and to recycle Pol II back to the promoter (1-3). As such, termination is an intricately controlled process that is tightly regulated by a variety of different cis- and trans-acting factors (4, 5). Although many eukaryotic termination factors have been identified to date, the details of the precise molecular mechanisms governing termination remain to be elucidated. We devised an in vitro transcription system to study specific Pol II termination. We show for the first time that the exonucleolytic Rat1·Rai1 complex can elicit the release of stalled Pol II in vitro and can do so in the absence of other factors. We also find that Rtt103, which interacts with the Pol II C-terminal domain (CTD) and with Rat1, can rescue termination activity of an exonucleolytically deficient Rat1 mutant. In light of our findings, we posit a model whereby functional nucleolytic activity is not the feature of Rat1 that ultimately promotes termination. Degradation of the nascent transcript allows Rat1 to pursue Pol II in a guided fashion and arrive at the site of RNA exit from Pol II. Upon this arrival, however, it is perhaps the specific and direct contact between Rat1 and Pol II that transmits the signal to terminate transcription.
Continuous micro-indenter push-through technique for measuring interfacial shear strength of fiber composites

Abstract This paper describes a continuous push-through, micro-indentation technique for measuring the fiber-matrix interfacial shear strength. E-glass fibers embedded perpendicular to the plane of thin polished specimens of epoxy matrix, with and without coupling agents, were indented with a micro-indenter until failure of the interface occurred and the fibers were pushed through the epoxy. The results show over 60% higher interfacial shear strength for fibers with coupling agent than for fibers without coupling agent. Average shear strength values obtained via the indentation technique are in good agreement with those obtained from the single-fiber-composite test. Absence of acoustic emission signals for debonding of the fibers coupled with no sudden drops in load vs indentation depth suggest that in this geometry the debonding is a slow, continuous process for both fiber surface treatments.
FACTOR ANALYSIS APPLIED TO WINE DESCRIPTORS

Eighty-six descriptors commonly used to characterize wines were evaluated by 86 respondents. The list was reduced to 33 descriptors which had the greatest meaning. Panels of 33 and 18 judges, respectively, evaluated 14 red and 12 white table wines for acceptability. For each descriptor, each wine was compared against a red or white reference wine. The tines had originally been purchased based on price and general repute as to quality. The panels did not rank the most expensive wines as the most acceptable. For the red wines, 27 descriptors were used for factor analysis. Eight factors were extracted and 14 well defined, oblique simple-structure planes were identified. For the white wines, six factors were extracted and 11 planes identified.
Orthogonality and normalization of torsional modes of vibration of solid elastic spheres

In this paper the work of Lamb on the free torsional vibrations of spheres (or “Vibrations of the First Class”) has been extended. In particular the conditions for the orthogonality of the normal modes have been established. These conditions have allowed the normalized displacements to be presented as a function of the radial distance from the centre of the sphere. Three-dimensional diagrams have been devised which show the displacements of the surface of the sphere. These modal diagrams also show the nodes and nodal lines.
Light Apparatus for Mesocosm Photo-manipulation (LAMP): An inexpensive waterproof lighting device for within-lake mesocosm experiments

Although light is a key biological driver, light additions to in-lake experiments can be difficult, if not impossible. To address this problem, we developed an inexpensive Lighting Apparatus for Mesocosm Photo-manipulation (LAMP), a device that can be deployed within experimental underwater enclosures to increase ambient light levels. Each apparatus consists of 12 Light Emitting Diode (LED) flashlights embedded within a watertight PVC frame. Through the use of a voltage regulator, each is wired to a 12V deep-cycle marine battery. Twelve LAMPs were deployed during a 3.5-week mesocosm experiment in Cranberry Lake in the Adirondack region of New York State and run 12 hours per day. LAMPs proved durable under harsh wind and weather conditions. Mesocosms with LAMPs had significantly higher average Photosynthetic Photon Flux Density (PPFD) in the water column than did controls (8% higher integrated Photosynthetic Active Radiation [PAR] over a 1.75 m depth, paired t test, P < 0.01). Other potential research applications for LAMPs include (1) testing light limitation in highly eutrophic systems where algal biomass may be self-shading, (2) experimentation at depth (e.g., examination of light limitation at the deep chlorophyll maximum), (3) application at different depths or in water bodies where specific wavelengths have been naturally attenuated using LEDs with different spectral properties, (4) testing animal responses to light climate in the field, or (5) collection of macroinvertebrates or fish larvae in modified LAMP-based light traps.
The influence of left ventricular filling pressure on atrial contribution to cardiac output

The influence of left ventricular filling pressure on the atrial contribution filling pressure and atrial contribution was seen in studies done at baseline (PCW (r=-.53, p less than .025), as well as in studies done after PCW was modified by volume expansion and/or nitrates (r=-.53, p less than .005). At baseline, atrial contribution averaged 9.3 +/- 1.3 c.c./M.2 in patients with PCW less than 20 mm. Hg, while it was only 2.4 +/- 1.2 c.c./M.2 in patients with PCW greater than or equal to 20 mm. Hg (p less than .005). Atrial contribution was significantly greater in patients who had no history of heart failure when they were volume loaded to a PCW above 20 mm. Hg than in patients with impaired ventricular function whose baseline PCW was above 20 mm. Hg. Thus, atrial contribution tends to be less effective in augmenting cardiac output when filling pressure is already elevated, particularly in patients with impaired left ventricular function.
Is the cesarean delivery rate increased in the unengaged primigravida at term

Objective: To determine whether station (STAT) of the vertex (VTX) in term primigravid (G1) singleton pregnancy predicts mode of delivery (MOD). Methods: Retrospective chart review of 304 singleton, VTX, 37-42-week gestation G1s admitted in labor during 1999. Data included demographics, STAT, membrane and cervical status on admission, gestational age (GA), pelvic assessment, pitocin augmentation, maternal weight and height, infant birth weight, MOD, and indications for cesarean delivery (CD). Statistical methods included (2, t test, and multiple logistic regression analyses. Since 79% overall had epidural analgesia, this variable was not included in the logistic model. Results: STAT at presentation was at or above -2 in 59.2% of patients, and in 87.5% it was -1 or above. Preliminary results reveal a CD rate of 18.4%. Most common indications were arrest of active phase/cephalopelvic disproportion (75.9%) and fetal indications (13.6%). The risk of CD was significantly associated with higher STAT (P = 0.003) and advancing GA (P = 0.007), and marginally associated with maternal age (P = 0.052), but not with race or pitocin use. Average BMI was higher for mothers with CDs (P = 0.006). Predictors of CD were GA (P = 0.002), borderline pelvis (P = 0.004), and STAT (P = 0.0019). However, STAT became nonsignificant when BMI was added to the model. Conclusion: A high STAT at presentation, advanced GA or a borderline pelvis, or both, are significant predictors of CD. There seems to be a significant interaction between BMI and STAT. In institutions in which unengaged and obese G1s are common, primary CDs are likely to be high.
Reduction in data collection for determination of cultivar coefficients for breeding applications

Abstract Plant breeding applications of crop simulation models require cultivar coefficients of new breeding lines. These cultivar coefficients are normally estimated from field experiments conducted under optimum conditions over several environments with elaborate data collection for each line throughout its life cycle. Such an intensive sampling scheme poorly applies to breeding lines at the early testing stages, because the number of lines is large and seed supply is limited. The objective of this study was to determine the minimum data to be collected for the estimation of cultivar coefficients of peanut lines for breeding applications of the CSM-CROPGRO-Peanut model. Nine peanut lines varying in maturity were selected for this study. Data on plant growth and development stages of these lines that were collected following the recommended procedure were obtained from a previous study. These data were used in a stepwise procedure to determine the minimum plant characteristics required for deriving the cultivar coefficients. This included both the intensity of data collection as well as the type of phenological and growth characteristics. The full versus partial data sets were then used for model calibration to derive the cultivar coefficients and an independent data set was used for model evaluation. The results showed that (i) different types of reduced phenological data resulted in the same values of the cultivar coefficients; (ii) cultivar coefficients derived from some reduced growth data sets were as good as those derived from full data collection; (iii) model calibration of cultivar coefficients derived from various types of reduced data collection worked well for all development characteristics and fairly well for the normalized root mean square error (RMSEn) values of the plant growth characteristics; and (iv) model evaluation showed good agreements between observed and simulated values for all growth and development characteristics. These results showed that it is possible to reduce the data collection for cultivar coefficients determination. The minimum data suggested is to determine two developmental stages, i.e., first flowering (R1) and harvest maturity (R8), and three plant samplings for growth analysis, i.e., around the stages of full seed (R6), physiological maturity (R7) and harvest maturity (R8).
Muscarinic receptors in developing rat colon

Muscarinic receptor subtypes were characterized in fetal (21 day), newborn (3 day), and adult (3 month) rat colon smooth muscle. Saturation binding of the nonselective muscarinic antagonist radioligand [3H]quinuclidinyl benzilate revealed a single class of binding sites in all three age groups. The binding affinities of [3H]quinuclidinyl benzilate were not significantly different among three age groups (KD: 0.19-->0.27 nM). In contrast, the receptor densities (Bmax, fmol/mg protein) showed a significant age-related decrease with fetus (518.9 +/- 7.4) > newborn (480.3 +/- 45.6) >> adult (192.4 +/- 32.8). In both newborn and adult tissues, the muscarinic agonist carbachol bound to two sites with high and low affinities. Although the agonist binding affinities in the newborn tissue were not significantly different from those in the adult tissue, the high-affinity binding sites for carbachol were significantly increased in the later (41%-->61%). Addition of guanosine-5'-O-(3-thio)triphosphate (100 microM) abolished apparent high-affinity binding sites in both newborn and adult tissues. Antagonist competition binding in the newborn tissue indicated a homogeneous population of muscarinic M2 receptors. Unlike in newborn tissues, the heterogeneous binding of pirenzepine and 4-diphenylacetoxy-N-methylpiperidine methobromide in adult tissues revealed coexistence of muscarinic M3 (45%) and M2 (55%) receptors. In accordance, activation of muscarinic receptors in the adult tissue stimulated synthesis of inositol 1,4,5-trisphosphate. These results suggest maturational changes of muscarinic receptor subtypes and their coupling to G proteins in rat colonic smooth muscle. These changes may account, at least in part, for developmental alterations of functional responses in colonic smooth muscle.
Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity

The discovery, proposed binding mode, and optimization of a novel class of Rho-kinase inhibitors are presented. Appropriate substitution on the 6-position of the azabenzimidazole core provided subnanomolar enzyme potency in vitro while dramatically improving selectivity over a panel of other kinases. Pharmacokinetic data was obtained for the most potent and selective examples and one (6n) has been shown to lower blood pressure in a rat model of hypertension.
Glycogen metabolism of human diploid fibroblast cells in culture. I. Studies of cells from patients with glycogenosis types II, 3, and V.

Extract: Glycogen synthetase, phosphorylase, debrancher, and acid maltase activities were measured in fibroblasts from normal subjects and from five patients with three different forms of glycogen storage disease. Acid maltase was absent in fibroblasts from two patients with glycogenosis type II, debrancher activity was decreased in fibroblasts from two patients with glycogenosis type III, and phosphorylase activity was normal in fibroblasts from one patient with glycogenosis type V. Fibroblasts from patients with glycogenosis types II and III accumulated more glycogen than normal cells; glycogen concentrations were about twice normal 10 days after subculture. In both types of mutant cells, glucose starvation was followed by rapid utilization of glycogen. Effective metabolism of glycogen in cells devoid of acid maltase activity makes the role of this enzyme uncertain. Speculation: Glycogen is stored excessively in cultured skin fibroblasts from patients with glycogenosis types II (lack of acid maltase) and III (debrancher deficiency). The ready mobilization of glycogen in glycogenosis type II cells challenges the postulated lysosomal mechanism of this disease, or indicates that this in vitro system is not exactly comparable with the in vivo situation.
Evaluation of effective flange width by shear lag model for orthotropic FRP bridge decks

Abstract In bridge engineering, the three-dimensional behavior of a bridge system is usually reduced to the analysis of a T-beam section with a reduced width of deck in relation to center-to-center spacing of stringers, over which the longitudinal normal stresses are assumed to be uniformly distributed, which is termed as effective flange width. It is defined in the AASHTO specifications primarily for concrete slabs and has inherent applicable limitations because of its empirical nature. This paper provides an analytical shear lag model for effective flange width for orthotropic bridge decks, applicable to various materials including Fiber-Reinforced Polymer (FRP) and concrete decks. To verify this solution, a Finite Element (FE) parametric study is conducted on 44 simply-supported FRP deck-on-steel girder bridges. The results from the shear lag model correlate well with the FE results. The accuracy of this model is further verified by close correlations with an existing empirical solution. It is also illustrated that the shear lag model, with the introduction of a reduction factor, can be applied to predict effective flange width for FRP deck-on-steel girder bridges with partial composite action, by favorable comparisons between the analytical and testing results for a T-beam section cut from a one-third scaled bridge model, which consists of an FRP sandwich deck attached to steel girders by mechanical connectors.
A heuristic procedure for the detection of locally similar substructures of two equivalent structures

A heuristic procedure is presented for the detection of locally similar substructures in two equivalent molecules, using elementary graph theoretical concepts. The capabilities of the procedure are demonstrated on the comparison of the calmodulin backbone in the X-ray structure and in a structure obtained from molecular dynamics.
Subnanosecond time resolved measurements of synchrotron X-ray pulses using photoconductive detectors

Abstract We have employed fast photoconductive detector (InP:Fe) and a sampling oscilloscope to time resolve the X-ray emission from the SPEAR storage ring. The detector and recording system had a response time (fwhm) of less than 200 ps. For photon energies between 1000 and 3000 eV we observed a Gaussian shaped pulse with a fwhm of 560 ps.
New Route from Si−O to Si−C Bonds: Alkylalkoxysilanes from Alkoxysilanes and Metal Hydrides

The typical pathway from silicon−oxygen to silicon−carbon bonds involves nucleophilic attack of an organometallic reagent on the silicon center. A new transformation from silicon−oxygen to silicon−...
Parental assessment of executive function and internalizing and externalizing behavior in primary hypertension after anti-hypertensive therapy.

Objective To determine the change in parental ratings of executive function and behavior in children with primary hypertension after anti-hypertensive therapy. Study design Parents of subjects with untreated hypertension and control subjects completed the Behavior Rating Inventory of Executive Function (BRIEF) to assess behavioral correlates of executive function and the Child Behavior Checklist (CBCL) to assess internalizing and externalizing behaviors. Subjects with hypertension subsequently received anti-hypertensive therapy to achieve casual blood pressure (BP) Results Twenty-two subjects with hypertension and 25 normotensive control subjects underwent both baseline and 12-month assessments. The BP of subjects with hypertension improved (24-hour systolic BP [SBP] load: mean baseline versus 12-months, 60% versus 25%, P P = 0.001), but not in the normotensive control subjects (Δ = –0.36, P = .83). In contrast, T-scores on the CBCL Internalizing and Externalizing summary scales did not change significantly from baseline to 12 months in either subjects with hypertension or control subjects. Conclusions Children with hypertension demonstrated improvement in parental ratings of executive function after 12 months of anti-hypertensive therapy.
Optimal beam frequencies by the finite element displacement method

Abstract A finite element displacement formulation is used to maximize the first mode natural frequency of a vibrating beam of specified volume with elastically restrained ends and resting on a continuous elastic foundatior subject to a constraint of minimum allowable moment of inertia. For cross-sections with moment of inertia and area related by I = pA n (p and n are positive constants), the optimality condition is reduced to a relation between the strain energy and kinetic energy densities. Beginning with a uniform beam, an iterative procedure is used to converge to the optimum material distribution and maximum first mode frequency. Results are presented for various boundary conditions, with and without the effect of any given arbitrarily varying axial load distribution and/or dead mass distribution for n = 1, 2 and 3.
Immunological comparisons of the crystal protein from strains of Bacillus thuringiensis

The parasporal crystal from Bacillus thuringiensis var. kurstaki strain 27 (HD-1) was solubilized by alkali and the 130,000-Da crystal protein was purified by column chromatography. Antibody specific to this protein was obtained and used to study the relationship among crystal proteins from 66 strains of B. thuringiensis representing 20 flagella and 11 crystal serovars. On the basis of the results of Ouchterlony immunodiffusion studies and experiments involving the quantitative microcomplement fixation technique, the crystal proteins were assigned to five groups. These assignments were consistent with a number of previous studies. There were also, however, some discrepancies in that crystal proteins from strains with a previously determined flagella and crystal serovar were found in several of our crystal groups. No phenotypic properties were found which would distinguish the strains of one crystal group from those of another. Some possible reasons for these discrepancies are discussed.
Supramolecular protein cage composite MR contrast agents with extremely efficient relaxivity properties

A DTPA-Gd containing polymer was grown in the interior of a heat shock protein cage resulting in T(1) particle relaxivities of 4200 mM(-1) sec(-1) for the 12 nm particle. Relaxivity parameters were determined, and this analysis suggests that the rotational correlation time has been optimized while the water exchange lifetime is longer than optimal. This synthetic approach holds much promise for the development of next generation contrast agents and this report will aid in their design.
Progress in the Theory of Economic Progress

The problem of economic development was among the main preoccupations of the classical economists; and Karl Marx, Max Weber, and their followers continued to be interested in it. The Anglo-Saxon economists and their followers, however, during the century preceding the Second World War, all but forgot about economic development—perhaps because they took it for granted. The growth of most of the advanced economies was impressive enough to be taken for granted; as for the underdeveloped areas, next to nothing was known about their rates of growth, although economists (at least in the advanced countries) seem to have supposed that the magnitude of capital exports to these areas gave them a chance to develop even faster than, and ultimately to catch up with, the more highly developed Western economies. Only England's development received some attention and mild doubts were occasionally raised as to whether her rate of economic growth was as fast as it could and should have been. From the turn of the century onward, blue books and white papers appeared, uneasily comparing British with German and American industrial production, questioning the wisdom of exporting quite so much capital, stressing the need for more aggressive export drives—but next to nothing was done about all this. For one thing, the philosophy of laisser faire still ruled supreme; for another, business fluctuations obscured and rendered difficult a true assessment of the situation; for a third, Britain's continued political supremacy may have lulled concern over the deterioration of her relative economic position. The problem of development came to the forefront of economic discussion only with the Second World War, as a result of two important changes. In the West, political power shifted across the Atlantic; in the East, Russia's war record established her both as an important center of political attraction and as a shining example of the success of planned industrialization and development.
Klippel-Trénaunay syndrome. An unusual presentation of unilateral leg edema.

Klippel-Trenaunay syndrome is a rare congenital condition that classically presents as a triad of varicosities, bone or soft-tissue hypertrophy, and cutaneous hemangiomas. The authors describe a case of this disease in an otherwise healthy patient with unilateral leg edema and intermittent bleeding from prominent ankle varicosities. The diagnosis was made on the basis of clinical presentation, diagnostic studies, and a comprehensive literature review. An overview of the pathology, treatment, and prognosis of this disease is provided.
The group-theoretical structure of the atomic d shell and the energies of the corresponding terms

The icosahedral symmetry I ≈ A 5 of the atomic d shell can arise from the symmetries of the five-dimensional d orbital space through the subgroup chain SO(5) ⊃ SO(3) ⊃ I or O(5) ⊃ S 6 ⊃ S 5 ⊃ I. In the latter case the symmetric group S 5 can be generated from I ≈ A 5 by addition of the period 4 kaleidoscope operator K, which mixes the d orbitals with m = ±1 and those with m = ±2. Furthermore, separation of the d n configurations into two sets according to the parity of n (even or odd) and the irreps of SO(5) is found to lead to new relationships between the multiplicities and seniorities of the corresponding terms. Thus the sums of the seniorities and multiplicities for even and odd n for a given irrep of SO(5) lead to a constant, namely 12. Furthermore, new pseudodegeneracies are found to arise when the energy expressions of pairs of otherwise equivalent terms with different seniorities for a given d n are adjusted to remove the radicals arising from solution of the quadratic secular equation. In additio...
uvby FCAPT photometry of the mCP stars HD 32633, θ Aur, 49 Cam, and 3 Hya

Differential Stromgren uvby observations from the Four College Automated Photoelectric Telescope are presented for the magnetic Chemically Peculiar (mCP) stars HD 32633, θ Aur, 49 Cam, and 3 Hya. We find for over 30 years, these four stars with stable optical region light curves have had constant periods of 6.4300, 3.61868, 4.28679, and 11.305 days, respectively.
Dynamics of myoglobin: comparison of simulation results with neutron scattering spectra.

Abstract Molecular dynamics simulations are used to calculate the incoherent neutron scattering spectra of myoglobin between 80 K and 325 K and compared with experimental data. There is good agreement over the entire temperature range for the elastic, quasi-elastic, and inelastic components of the scattering. This provides support for the accuracy of the simulations of the internal motions that make the dominant contributions to the atomic displacements on a time scale of 0.3-100 ps (100-0.3 cm-1). Analysis of the simulations shows that at low temperatures a harmonic description of the molecule is appropriate and that the molecule is trapped in localized regions of conformational space. At higher temperatures the scattering arises from a combination of vibrations within wells (substates) and transitions between them; the latter contribute to the quasi-elastic scattering.
Tradition, tension, and transformation: a structuration analysis of a game warden service in transition

Independence and competence define the traditional characteristics of a game warden. External pressure to transform the game warden service into a more culturally and ethnically diverse state law enforcement agency, however, creates tensions surrounding these characteristics in the organization's structurationally defined agency and reflexivity of law enforcement; duality of structure in office memos and citation counts; social integration and institutional reproduction of law enforcement training, use of decoys, and search and seizure procedures; and time-space distanciation of working a 40-hour week or having complete responsibility for a territory. The present study examined how these tensions interact with the traditional assumptions of independence and competence to transform the meaning of these characteristics, and of the game warden service itself.
Prediction intervals for the random intercept linear model

Our main purpose is to give a method of constructing prediction intervals for the mean of us future observations in the random intercept linear model, A method is also indicated for constructing exact confidence intervals on the expected value of a future observation.
Continuing education, industry, and physicians.

![Figure][1] In no other profession is lifelong continuing education as valued and pursued as in medicine. Our profession is one in which the fund of knowledge is constantly increasing. We physicians pride ourselves on keeping abreast of new information and providing patients with the best
Effect of testosterone and growth hormone on nucleic acid and protein in the sex accessory glands of Long-Evans and Sprague-Dawley rats.

Growth of the sex accessory glands was studied in hypophysectomizedcastrated male rats of the Long-Evans and the Sprague-Dawley strains, following the injection of testosterone propionate, bovine growth hormone, or a combination of the two hormones. Testosterone propionate, 300 μg/day, effected similar increases in the wet weight, the protein and the ribonucleic acid (RNA) of the ventral prostate and the seminal vesicles in rats of both strains. Growth hormone itself was ineffective in stimulating growth of the sex accessory glands; however, when given with testosterone, it enhanced their response with respect to the synthesis of both RNA and protein.
Use of capillary zone electrophoresis for the analysis of DNA-binding to a peptide derived from amyloid P component

Abstract Capillary zone electrophoresis was used to characterize the binding interactions between oligonucleotides and synthetic peptides derived from human serum amyloid P component. From a solution containing free and peptide-bound oligonucleotides, free nucleotide was separated from the complex by means of electrophoresis. In this way, both qualitative and quantitative aspects of the binding could be assessed rapidly using minute amounts of unlabelled samples. Minimal structures and sequence specificity of binding of nucleotides and peptides could be characterized and, based on the quantitative output of the electrophoretic analysis, binding constants were estimated. In theory, the approach is applicable for any molecular interaction where the charge/mass ratio of complexes differ from the free molecules and where at least one of the interacting components is quantitatively recoverable and detectable in the capillary electrophoresis system. As such, it is the only method available for simple and fast e...
The effect of neurotensin on the concentration of cholesterol and bile acids in the guinea pig

In guinea pigs, total plasma cholesterol concentrations increased above the control values after single intravenous injections and after 3 days of continuous subcutaneous administration of neurotensin (NT). A high dose of NT (125 pmol/100 g body weight) induced tachycardia and severe respiratory distress; the lowest dose (1.25 pmol/100 g body weight) had the greatest hypercholesterolemic effect 15 min after the injections. The bulk of the total plasma cholesterol was in low density lipoprotein fractions. Cholesterol increased in the same fractions after intravenous administrations of NT. NT induced a decrease in the cholesterol content in the ileum but did not affect significantly the cholesterol content in the liver, kidneys or adrenals. In 48-hr fasted controls, plasma cholesterol concentration and cholesterol content in the liver, kidneys, adrenals and terminal ileum increased; after intravenous injections of NT, plasma cholesterol concentration further increased but cholesterol content of the liver, kidneys and ileum decreased. In fed animals, the concentration of the biliary taurochenodeoxycholic acid increased above the control values 5 and 35 min after the intravenous injections of NT. In fasted controls, the total concentration of bile acids was higher than in fed controls, but only the concentration of taurochenodeoxycholic acid further increased after the injections of NT. Proportionately more taurochenodeoxycholic acid than cholesterol was present in bile after the intravenous injections of NT. These data are consistent with the hypothesis that NT has a regulatory role in intestinal cholesterol transport.
Biodiversity, climate, and the Kyoto Protocol: risks and opportunities

Climate change is occurring at the same time as another problem of global and historical proportions – the sixth mass species extinction crisis in the history of life on earth. Wide-scale deforestation is fueling climate change and biodiversity loss, and is expected to greatly accelerate biodiversity loss and species extinctions. Recognizing the intimate interconnection between these two global problems and designing resilient actions that address both simultaneously is more important than ever; humanity has neither the time nor the financial resources to treat these challenges separately and sequentially. We must establish an international framework to encourage synergistic actions that capture multiple benefits while avoiding negative trade-offs. The Kyoto Protocol, as currently written, does little to advance such convergent solutions, and in many ways could unwittingly promote further biodiversity loss. Here we outline the risks associated with this climate treaty and suggest possible approaches that could capture otherwise lost opportunities.
On the "equine species" in clinical medicine.

Plaidoyer sur l'importance du depistage neonatal des maladies metaboliques hereditaires, sous-tendu par l'idee que, a la naissance, grâce a l'activite metabolique de l'unite fœtomaternelle, les enfants atteints ne se distinguent pas cliniquement
Effect of moisture content at harvest and degree of milling (based on surface lipid content) on the texture properties of cooked long-grain rice.

ABSTRACT The effects of the degree of milling (based on surface lipids content [SLC]) on cooked rice physicochemical properties were investigated. Head rice yield (HRY), protein, and SLC decreased with increasing milling, while the percent of bran removed and whiteness increased. Results showed that SLC significantly (P < 0.05) affected milled as well as cooked rice properties across cultivar, moisture content (MC) at harvest, and location (Stuttgart, AR, and Essex, MO). Cooked rice firmness ranged from 90.12 to 111.26 N after milling to various degrees (SLC). The decrease in cooked rice firmness with increasing milling was attributed to the lowering of total proteins and SLC. Cooked rice water uptake increased with increasing degree of milling. Water uptake by the kernel during cooking dictated the cooked rice firmness. The increase in cooked rice stickiness with increasing degree of milling was attributed to an increase in starch leaching during cooking because of the greater starch granule swelling ass...
Measures of human influence in habitats of South Asian monkeys

Human disturbance of habitat has important consequences for the demography, the morbidity, the behavior, and ultimately the survival of non-human primates. This paper is an effort to define, qualitatively, the potential influence of humans on monkey habitats and behavior in South Asia. Four variables are proposed and scored on a fourpoint scale. These variables can be used in comparisons within and between species. The four variables are description of the home range, level of harassment of the animals, habituation of the animals to humans, and the presence of predators. These measures are intentionally simple and conventional so that information may be retrieved from earlier field studies, and sites scored retrospectively. Methods for some continuous numerical measures of human influence are proposed for future studies.
CORRELATIONS BETWEEN STANDARD ENGLISH AND DIALECTICAL SPANISH VERSIONS OF FIVE PERSONALITY SCALES

Although there have been increased attempts to provide bilingual, bicultural mental health services to Spanish-speaking residents of major Southwestern cities, little effort has been directed toward the development and testing of Spanish versions of easily administered personality scales for use in assessment, treatment, and evaluation. The Spanish versions of the five tests were developed for use as a part of a project involving native Spanish-speaking clients at the Austin Child Guidance Clinic. Tests selected for the project included the Rational Behavior Inventory that provides an index of rational beliefs based on 37 items scored on a five-point Likert scale (2, 3, 4) . Other scales included a five-item Anomia scale developed by Srole; a 10-item Self-esteem scale developed by Rosenberg; a 10-item Dogmatism scale developed by Schulze; and a 4-item Authoritarianism scale developed by Lane ( 1 ) . A preliminary version of each scale was developed by integrating independently developed stimulus items constructed by rwo native bilingual social work students of Mexican descent. The preliminary items were then independently reviewed by two native bilingual social workers of Mexican descent for choice of words, sentence construction, and verbal flow. The final items were then selected jointly by the social work professionals. Thirty-two native bilingual students of Mexican descent from four sections of a lower division Mexican American studies class at the University of Texas at Austin completed both the Spanish and English versions of the test. Half of the students first complered the English version followed by the Spanish version of the test, and the others completed the test in the opposite order. Correlation coefficients computed for the English and Spanish versions of each test were all significant ( p < .DO1 ) . Values of the correlations included: Rational Behavior Inventory (.93 ) , Self-esteem scale ( .91), Anomia scale (.97 ) , Authoritarianism scale (.77), and the Dogmatism scale ( .88). Differences between the means of the English and Spanish versions of all five tests were analyzed using t test. Means and standard deviations for the English and Spanish versions, respectively, were: Rational Behavior Inventory (22.78 and 5.33; 23.34 and 5.63), Self-esteem scale (8.08 and 2.20; 7.83 and 2.41), Anomia scale (2.31 and 1.51; 2.17 and 1.47), Authoritarianism scale (2.00 and 1.16; 1.93 and 1.24), and Dogmatism scale (4.69 and 1.89; 4.86 and 2.10). A significant difference between mean scores was found only for the Anomia scale ( p < .05). The difference between the mean scores on the English and Spanish versions of the Anomia scale were small but significant; SDs were small. These results provide preliminary support for use of the Spanish dialectical versions of the four scales.
Non-sensory involvement of the olfactory bulbs in the mediation of social behaviors.

Bilateral removal of the olfactory bulbs produces a syndrome of profound and apparently permanent social behavioral deficits. These deficits are not seen when mice are rendered anosmic by a peripheral manipulation not affecting the integrity of the olfactory bulbs. Apparently the olfactory bulbs are importantly involved in a non-sensory manner in the control of social behaviors in the mouse.
Characteristic Views As A Basis For Three-Dimensional Object Recognition

This paper describes a new technique for modeling 3D objects that is applicable to recog-nition tasks in advanced automation. Objects are represented in terms of canonic 2D models which can be used to determine the identity, location and orientation of an unknown object. The reduction in dimensionality is achieved by factoring the space of all possible perspective projections of an object into a set of characteristic views, where each such view defines a characteristic-view domain within which all projections are topologically identical and related by a linear transformation. The characteristic views of an object can then be hierarchically structured for efficient classification. The line-junction labelling constraints are used to match a characteristic view to a given unknown-object projection, and determination of the unknown-object projection-to-characteristic view transformation then provides information about the identity as well as the location and orientation of the object.
Raman scattering techniques applied to problems in solid state physics

A discussion of the application of Raman scattering to solid state problems is followed by a description of the experimental technique. A recent experiment is described in which the thickness of the domain wall in the strongly coupled ferroelectric–ferroelastic material gadolinium molybdate is found to be within the limits 0.8–3 μ. The Raman scattering from part of the wall volume is characteristic of the high temperature paraelectric phase.
A Sensitive DRVVT Reagent System for the Detection of Lupus Anticoagulants

Lupus anticoagulants are antibodies that inter fere with the phospholipid-dependent steps in in vitro blood clotting. The dilute viper venom (DVV)test is a phospholipid-limiting assay in which a pl...
Effect of Panel Joints on the Performance of Cold-Formed-Steel Light-Frame Shear Walls

AbstractSome existing qualification/validation data for alternatives to code-compliant light-frame cold-formed steel (CFS) shear wall construction were developed before requirements for test specimens with 1∶1 aspect ratios and the inclusion of a vertical panel joint. These requirements were introduced on the notion/assumption that walls with an included panel joint and 1∶1 aspect ratio provide a lower bound estimate of wall performance (strength, displacement, and toughness). In this technical note, data from three independent experimental test programs were analyzed to shed light on panel joint and aspect ratio effects on cold-formed steel frame shear wall performance. The analysis showed that the performance of walls without a panel joint and with aspect ratios as high as 214∶1 provide reasonable lower bound measures of performance.