cssi/SciSciGPT-SciSciNet huggingface dataset:
Ambulatory electrocardiographic monitoring between artifacts and misinterpretation, management errors of commission and errors of omission.

Background The aim of the study is to contrast the role of conventional ambulatory electrocardiographic monitoring (AEM) artifacts with a less emphasized problem with potentially more serious implications, that is, the failure to recognize, and therefore misinterpret, a genuine arrhythmia episode in the AEM recording. Methods The study material included 500 Holter recordings and 500 recordings from the cardiac telemetry unit. Results Electrocardiographic (ECG) artifacts were more common in telemetry recordings (5.6%) compared to Holter recordings (4%) for a total of 4.8%. There were 35 examples of misinterpretation of AEM recordings (3.5%). These were significantly more common in telemetry recordings (2.6%) compared to Holter recordings (0.9%). The most common ECG artifacts were examples of pseudo ventricular tachyarrhythmia (VT). The majority of misinterpretation (26 of 35 examples) were fast supraventricular tachyarrhythmias with aberrant QRS (including six examples of atrial flutter with periods of 1:1 atrioventricular conduction) that were misdiagnosed as ventricular VT. Other examples were misinterpretation of arrhythmic episodes consistent with sick sinus syndrome, pacemaker malfunction, and long QT syndrome. Only 5 of 48 examples of AEM artifacts resulted in management errors of commission or errors of omission compared to all 35 examples of misinterpretation. Conclusions Compared to conventional artifacts in AEM, misinterpretation of nonartifactual arrhythmic episodes consistently resulted in management errors. Misinterpretation was significantly more common with telemetry recordings compared to Holter ECG. This highlights the need for more appropriate training of the entire clinical team in charge of the management of the cardiac telemetry unit.
Automatic deployment and formation control of decentralized multi-agent networks

Novel tools are needed to deploy multi-agent networks in applications that require a high degree of accuracy in the achievement and maintenance of geometric formations. This is the case when deploying distributed sensing devices across large spatial domains. Through so-called embedded graph grammars (EGGs), this paper develops a method for automatically generating control programs that ensure that a multi-robot network is deployed according to the desired configuration. This paper presents a communication protocol needed for implementing and executing the control programs in an accurate and deadlock-free manner.
Making Music, Reaching Readers Making Powerful Connections Possible for Young Students

In this article, the author makes a case for the arts enhancing learning. Examples of how music experiences can make valid connections to reading without demeaning music as an art form are presented. These examples include teaching strategies for building vocabulary and increasing comprehension, phonological awareness, and reading fluency through music.
Sober Drag Queens, Digital Forests, and Bloated “Lesbians”: Performing Gay Identities Online

This essay focuses on how gay podcasters, or “Qpodders,” perform their identities in “soundscape” environments. Most of the “data” presented in the report take the form of poetry, dramatic monologue, and dramatic dialogue. Using creative reporting strategies, I chronicle how Qpodders record the ambient sounds of the scenes in which they are embedded; and, as a result, I argue that, within the context of a podcast, nonverbal sounds are poetic and narrate.
The Outreach of Dialogue

This talk, which is a lightly edited transcription of an award address, summarizes the author’s latest thinking about the value and practical application of Buber’s dialogical approach to relationships, both for individuals and society at large.
Analysis of fermentation processes using flow microfluorometry: Single-parameter observations of batch bacterial growth

The laser flow microfluorometer (FMF) can determine the amounts of certain components in single cells at sample rates of several thousand cells per second. This technique has been employed to characterize Bacillus subtilis populations in batch fermentations with different inocula. Protein and nucleic acid distributions obtained by FMF analyses at different times during the batch have been decomposed using an optimized fit of summed subpopulation distributions. The results of these decomposition calculations, some of which have been approximately confirmed by independent microscopic observations, indicate that the relative numbers of single rods, cell chains, spores, and swollen rounded cells change dramatically during the entire fermentation including the stationary phase. The dynamics of these subpopulations may be related to secondary metabolite production.
Development of scatterometer-derived surface pressures for the Southern Ocean

[1] High-resolution, research-quality surface pressures are objectively calculated over the Southern Ocean using winds derived from the SeaWinds scatterometer on the QuikSCAT satellite. The pressure fields are validated in comparison to in situ observations. Overall, the scatterometer-derived surface pressures are a small improvement over the National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis, which is used as the objective technique’s background field. This improvement is understated primarily because the comparison data undersample storms. Instances are found where the NCEP/NCAR reanalysis misses storms entirely and the scatterometer-derived pressures are a large improvement (as much as 20 hPa). INDEX TERMS: 3337 Meteorology and Atmospheric Dynamics: Numerical modeling and data assimilation; 0350 Atmospheric Composition and Structure: Pressure, density, and temperature; 3360 Meteorology and Atmospheric Dynamics: Remote sensing; 4275 Oceanography: General: Remote sensing and electromagnetic processes (0689); KEYWORDS: scatterometer, surface pressure, variational techniques, Southern Ocean, SeaWinds, QuikSCAT
A high-speed integrated optoelectronic photoreceiver

The authors present a high-speed optoelectronic photoreceiver, specifically designed for use in optical interconnections. This photoreceiver is composed of an MSM (metal-semiconductor-metal) photodetector coupled with a HEMT (high electron mobility transistor) transimpedance amplifier. Through the use of the lattice-mismatched materials system of AlGaAs/InGaAs/GaAs and quarter-micron gate length HEMTs, speeds in excess of 4 GHz as well as transimpedance gains of over 50 dB were achieved, well matching the results of the iSMILE simulator. The high performance of the pseudomorphic HEMTs was reflected in their transit frequency of f/sub 1/=66 GHz. This design also included an MSM photodetector with a measured dark current of less than 10 nA. >
Integrated Platform for Collaborative Learning in the Mobile Environment

The internet application for education has changed as development of technology. The prevalence of Web 2.0 makes internet become an environment to share knowledge differ from traditional e-Learning systems. Moreover, mobile devices have become more and more popular as a result of the advance of device performance. How to integrate the Web 2.0 environment and mobile devices to create a mobile learning system becomes an important issue. In this paper, we design an integrated platform for collaborative learning and mobile learning. The platform allows users to edit learning materials collaboratively in a Wiki system and learners can study online with a handheld device.
Reversed-Phase High-Performance Liquid Chromatographic Separation of LY309887 (Thienyl-5,10-Dideazatetrahydrofolate) Stereoisomers Using β-Cyclodextrin as a Mobile Phase Additive

The separation of the four stereoisomers of LY309887 (thienyl-5,10-dideazatetrahydrofolate) is studied here using commercially available high-performance liquid chromatography column technology. The selectivity needed to resolve the four stereoisomers is provided by an achiral reversed-phase column used with beta-cyclodextrin as a mobile phase additive. The separation is dependent on triethylamine and beta-cyclodextrin concentration in the buffer portion of the eluent, eluent strength, and buffer pH.
Aligning Supply Chain Incentives Using the Balanced Scorecard

In recent years, much has been written about the merits of collaborative supply chain partnerships. However, this article contends that companies will fail to reap the potential rewards of collabor...
A new box iterative method for a class of nonlinear interface problems with application in solving Poisson-Boltzmann equation

In this paper, a new box iterative method for solving a class of nonlinear interface problems is proposed by intermixing linear and nonlinear boundary value problems based on a special seven-overlapped-boxes partition. It is then applied to the construction of a new finite element and finite difference hybrid scheme for solving the Poisson-Boltzmann equation (PBE) - a second order nonlinear elliptic interface problem for computing electrostatics of an ionic solvated protein. Furthermore, a modified Newton minimization algorithm accelerated by a multigrid preconditioned conjugate gradient method is presented to efficiently solve each involved nonlinear boundary value problem. In addition, the analytical solution of a Poisson dielectric test model with a spherical solute region containing multiple charges is expressed in a simple series of Legendre polynomials, resulting in a new PBE test model that works for a large number of point charges. The new PBE hybrid solver is programmed as a software package, and numerically validated on the new PBE test model with 892 point charges. It is also compared to a commonly used finite difference scheme in the accuracy of computing solution and electrostatic free energy for three proteins with up to 2124 atomic charges. Numerical results on six proteins demonstrate its high performance in comparison to the PBE finite element program package reported in Xie (2014). Present a new box iterative method for a class of nonlinear interface problems.Obtain a new hybrid solver of Poisson-Boltzmann Equation (PBE) as application.Develop a new Newton-PCG-MG scheme for nonlinear boundary value problems.Obtain a simple series solution for Poisson ball test model with multiple charges.Validate the new PBE hybrid software and demonstrate its high performance.
Very-low-dose adult brain F-18 FDG PET/CT

1855 Objectives The aim of this study is to evaluate if the radiation dose due to PET component in adult brain F-18 FDG PET/CT could be significantly reduced using recently introduced PET time-of-flight (FX) technique and SharpIR (SIR) algorithm. Methods Five adult patients underwent whole brain F-18 FDG PET/CT imaging using D690 (GE) PET/CT scanner, following the administration of 10 mCi of F-18 FDG. We obtained their brain PET images in 12-minute scans. We also simulated 70% dose reduction via reconstruction of simulated 4-minute scans from the acquired list data. FDG brain scans were reconstructed using VUE Point with FX and SIR algorithm. We used 2.0 mm Gaussian in-plane post filter, heavy axial filter and 18/4 and 16/8 subsets/iterations for full and half dose, respectively. Two groups of images were obtained: group A with 100% and group B with 30% dose, respectively. Four nuclear medicine physicians blinded to the administered activity independently reviewed the images and compared diagnostic quality of images. Results No significant differences were reported in the final interpretation of the images from A and B groups. Conclusions This study indicates that radiation dose from F-18 FDG PET for our 5 adult patients in whole brain PET/CT studies could be reduced 70% without compromising the diagnostic performance. The larger clinical trials are needed to confirm that 70% dose reduction could be applied to all adult patients.
Effect of Lipophilicity and Drug Ionization on Permeation Across Porcine Sublingual Mucosa

Sublingual route is one of the oldest alternative routes studied for the administration of drugs. However, the effect of physical-chemical properties on drug permeation via this route has not been systemically investigated. The objective of this study was to determine the effect of two key physicochemical properties, lipophilicity and ionization, on the transport of drugs across porcine sublingual mucosa. A series of β-blockers were used to study the effect of lipophilicity on drug permeation across the sublingual mucosa, while nimesulide (pKa 6.5) was used as a model drug to study the effect of degree of ionization on sublingual mucosa permeation of ionized and unionized species. Permeation of β-blockers increased linearly with an increase in the lipophilicity for the range of compounds studied. The permeability of nimesulide across sublingual mucosa decreased with an increase of pH. The flux of ionized and unionized forms of nimesulide was determined to delineate the contribution of ionized and unionized species to the total flux. At low pH, the apparent flux was primarily contributed by unionized species; however, when the pH is increased beyond its pKa, the primary contributor to the apparent flux, nimesulide, is ionized species. The contribution of each species to the apparent flux was shown to be determined by the thermodynamic activity of ionized or unionized species. This study identified the roles of lipophilicity and thermodynamic activity in drug permeation across the sublingual mucosa. The findings can help guide the design of sublingual drug delivery systems with optimal pH and solubility.
Evaluation of a Rapid Dye-Reduction Test for Bacterial Susceptibility to Antibiotics

The determination of the susceptibility of bacteria to antibiotics in vitro is now accepted as a standard procedure. By whatever method the sensitivity is determined, the data are used as a guide in the selection of the antibiotic most likely to be effective in treating a patient with bacterial infection. The 2 methods in general use are: (1) the broth serial dilution technic, and (2) the agar diffusion method, using either cups or antibiotic-impregnated paper disks. 9 It is not pertinent to review here the advantages or disadvantages of either method, nor the extensive literature on testing for antibiotic susceptibility. I t must be recognized, however, that the agar diffusion technic is the one most widely used in hospitals where cost, simplicity, reliability, and promptness of results must all be given due consideration.
Swarming and Mating Behavior of a Natural Population of Culicoides Variipennis (Diptera: Ceratopogonidae)

Swarms of Culicoides variipennis are described, which are similar to those of Culicoides nubeculosus . These swarms were confirmed as mating sites in which matings were seen every 10–15 s. Extensive mating occurred despite a female : male sex ratio in the swarm of only 1:167 (sampled by sweep net). Coupling took place at the periphery of the swarm. Pairs fell to the ground and remained in copula from 30 to 120 s. Increased time in copula significantly increased successful insemination. Among females arriving at the swarm, 99.0% were nulliparous. The size and shape of the sensory pit on the 3rd segment of the maxillary palp was not a useful character in classifying coupled females as either C. variipennis or C. occidentalis .
Microprobe analysis and dating of monazite from the Potsdam Formation, New York: A progressive record of chemical reaction and fluid interaction

It has been recognized for several decades that REE-phosphates (monazite and xenotime) can grow during diagenesis and low-grade metamorphism. Growth of REE-bearing accessory phases at low-grade conditions commonly involves pervasive fluid-rock interaction, dissolution of detrital grains, transportation, and precipitation of REEs, typically facilitated by an increase in temperature. The occurrence of low-grade REE-phosphate offers a rare opportunity to date crystallization/mineralization and possibly fluid percolation. We report here the results of in situ dating by electron microprobe of Paleozoic authigenic and low-grade monazite and xenotime overgrowths on detrital monazite and zircon, respectively. Samples are from the Potsdam Formation, a basal sandstone deposited uncomformably on Proterozoic basement of the Adirondack Mountains of New York State. This study also focuses on the textural and chemical relationships of these REE-bearing accessory phases. Textures include rounded and fractured detrital monazite and zircon, which contrast with new sub-euhedral REE-phosphate overgrowths. Monazite overgrowths are enriched in LREE and depleted in HREE compared to detrital cores. The U and Th concentrations are low, typical of low-grade metamorphic conditions. Monazite core ages yield Proterozoic ages between 1.17 and 0.90 Ga (Shawinigan and Ottawan orogeny). Monazite overgrowth and xenotime ages indicate four to five major overgrowth events between ca. 500 Ma (shortly after the time of deposition) and ca. 200 Ma. As these ages are relatively young and the actinide content is low (∑ < 2 wt%), the radiogenic Pb content of monazite overgrowths and xenotime is low (<400 ppm). Therefore, EPMA dates have relatively large uncertainties. Nevertheless, the ages determined broadly correlate with major Paleozoic orogenic events recorded in the Appalachian Orogen to the East (Taconic, Salinic, Acadian, Neo-Acadian, and Alleghanian). Fluid percolation, driven by orogenic loading, may induce dissolution of detrital monazite and zircon. Subsequent precipitation of new monazite and xenotime probably results from changes in fluids or metamorphic conditions. This study demonstrates the power of the EMPA technique to resolve the fluid-related growth history of REE-phosphates in low-grade metasediments.
Biomechanical Comparison of Bicortical, Unicortical, and Unicortical Far-Cortex-Abutting Screw Fixations in Plated Comminuted Midshaft Clavicle Fractures.

Purpose The objective of this study was to assess the biomechanical properties of bicortical locking screws, unicortical locking screws, and unicortical far-cortex–abutting locking screw fixation in a cadaver model of comminuted midshaft clavicle fractures stabilized with a locking plate placed on the superior surface of the clavicle. Methods Nine pairs of adult fresh-frozen cadaver clavicles were allocated into 3 groups for either bicortical, unicortical, or unicortical far-cortex–abutting locking plate fixation. After a 1-cm osteotomy to simulate a comminuted fracture and instrumentation with an 8-hole locking plate placed on the superior surface of the clavicle, the specimens were mounted in a custom dual-gimbal fixture in a materials-testing system and tested in axial compression, torsional, and torsional load to failure. Results Axial stiffness and axial osteotomy site stiffness did not demonstrate differences between constructs. In cyclical torsion, both the bicortical and the unicortical far-cortex–abutting constructs were significantly stiffer than the unicortical construct. For torsional failure stiffness, both the bicortical and the unicortical far-cortex–abutting constructs were significantly stiffer than the unicortical construct. There was no difference between bicortical and unicortical far-cortex–abutting for torsional failure stiffness. The bicortical construct exhibited significantly higher peak failure torque compared with the unicortical construct. Conclusions Unicortical far-cortex–abutting locking screw fixation provides comparable mechanical properties under axial and torsional loads to bicortical fixation, without penetrating the far cortex. Clinical relevance Unicortical far-cortex–abutting locking screw fixation obviates far cortex penetration, and thereby protects nearby anatomical structures, may ease symptomatic implant removal, alleviates refracture risk, and eases conversion to bicortical fixation in the case of revision surgery.
Treatment Strategies for Intracranial Fusiform Aneurysms

Fusiform aneurysms represent a small subset of intracranial aneurysms that form from the pathological circumferential dilatation of a length of cerebral artery. These lesions have separate inflow and outflow sites and frequently differ from saccular aneurysms in both their clinical presentations and surgical treatment. Thromboembolic complications and hemorrhage occur from these aneurysms. This article reviews the pathophysiology and clinical presentation of fusiform aneurysms and also discusses some of the special considerations regarding surgical treatment of these lesions.
Quantitative Analysis of Cortical Actin-Membrane Microcluster Interactions

The spatial organization of receptors on the plasma membrane is crucial for their signaling efficacy. Previous studies have implied that the cortical-actin (CA) meshwork regulates receptor mobility and organization in the plasma membrane. To understand the molecular mechanisms underlying this process, we sought to quantitatively study the role of the CA meshwork in regulating the clustering and mobility of receptors in an in vitro reconstitution system. Specifically, we are studying the mobility, organization and clustering of Linker for Activation of T cells (LAT) complexes in an artificial lipid bilayer with an attached actomyosin meshwork. Our quantitative analyses using light microscopy and computational image analysis have led to the very exciting observation that while LAT complexes exhibit predominantly confined diffusion in the absence of actin, they exhibit nearly equal populations undergoing confined and normal diffusion in the presence of a CA meshwork. Additionally, presence of a CA meshwork influences both the diffusion speed and size distribution of LAT clusters. These results suggest that actin may be playing a larger and more interesting role in influencing cluster dynamics that extends beyond static spatial organization. Future work will focus on determining the proteins that link LAT complexes to the CA meshwork and on extending this work to cells and other receptor systems.
Computational exploration of wave propagation and heating from transcranial focused ultrasound for neuromodulation.

Objective. While ultrasound is largely established for use in diagnostic imaging, its application for neuromodulation is relatively new and crudely understood. The objective of the present study was to investigate the effects of tissue properties and geometry on the wave propagation and heating in the context of transcranial neuromodulation. Approach. A computational model of transcranial-focused ultrasound was constructed and validated against empirical data. The models were then incrementally extended to investigate a number of issues related to the use of ultrasound for neuromodulation, including the effect on wave propagation of variations in geometry of skull and gyral anatomy as well as the effect of multiple tissue and media layers, including scalp, skull, CSF, and gray/white matter. In addition, a sensitivity analysis was run to characterize the influence of acoustic properties of intracranial tissues. Finally, the heating associated with ultrasonic stimulation waveforms designed for neuromodulation was modeled. Main results. The wave propagation of a transcranially focused ultrasound beam is significantly influenced by the cranial domain. The half maximum acoustic beam intensity profiles are insensitive overall to small changes in material properties, though the inclusion of sulci in models results in greater peak intensity values compared to a model without sulci (1%–30% greater). Finally, heating using currently employed stimulation parameters in humans is highest in bone (0.16 °C) and is negligible in brain (4.27 × 10–3 °C) for a 0.5 s exposure. Significance. Ultrasound for noninvasive neuromodulation holds great promise and appeal for its non-invasiveness, high spatial resolution and deep focal lengths. Here we show gross brain anatomy and biological material properties to have limited effect on ultrasound wave propagation and to result in safe heating levels in the skull and brain.
Deriving a probability density calculator (functional pearl)

Given an expression that denotes a probability distribution, often we want a corresponding density function, to use in probabilistic inference. Fortunately, the task of finding a density has been automated. It turns out that we can derive a compositional procedure for finding a density, by equational reasoning about integrals, starting with the mathematical specification of what a density is. Moreover, the density found can be run as an estimation algorithm, as well as simplified as an exact formula to improve the estimate.
Evaluation and Management of Pathologic Femur Fractures in Children

While the vast majority of femur fractures in children occur from moderate to high-energy accidental trauma, pathologic fractures are not uncommon and tend to occur in two settings: (1) fracture through a localized area of compromised bone integrity, usually secondary to a benign bone cyst or non-malignant tumor in the femur; or (2) fracture in the setting of globally or systemically compromised bone integrity, usually secondary to underlying neuromuscular disease, disuse osteoporosis, or a specific named metabolic bone disease.
Automatic Delineation of Seacliff Limits using Lidar-derived High-resolution DEMs in Southern California

ABSTRACT Palaseanu-Lovejoy, M.; Danielson, J.; Thatcher, C.; Foxgrover, A.; Barnard, P.; Brock, J., and Young, A., 2016. Automatic delineation of seacliff limits using lidar-derived high-resolution DEMs in Southern California. In: Brock, J.C.; Gesch, D.B.; Parrish, C.E.; Rogers, J.N., and Wright, C.W. (eds.), Advances in Topobathymetric Mapping, Models, and Applications. Journal of Coastal Research, Special Issue, No. 76, pp. 162–173. Coconut Creek (Florida), ISSN 0749-0208. Seacliff erosion is a serious hazard with implications for coastal management and is often estimated using successive hand-digitized cliff tops or bases (toe) to assess cliff retreat. Even if efforts are made to standardize manual digitizing and eliminate subjectivity, the delineation of cliffs is time-consuming and depends on the analyst's interpretation. An automatic procedure is proposed to extract cliff edges from high-resolution lidar-derived bare-earth digital elevation models, generalized coastal shoreline vectors, and approxim...
Ideological Currency in the Psychological Contracts of Corporate Manufacturing Employees

Previous research on employee psychological contracts has focused on three different types of expectations that workers have of their employers: transactional exchange of economic currency, relational exchange of socioemotional currency, and, more recently, covenantal exchange of ideological currency. This last type of currency, however, has been studied almost entirely in nonprofit workplaces among employees in helping professions (e.g., healthcare, education) who hold advanced degrees. Although not explicit in the extant literature, the implication of such is that expressions of ideological currency may be limited to certain types of professions. In the present study, we therefore analyzed both white and blue-collar employees’ ideological expectations in a corporate, for-profit, manufacturing environment. Using 1492 responses to an open-ended question received from an email survey, we found that 36% contained an expression of ideological currency, with an additional 44.8% possessing a possible expression of ideological currency. Comparisons of these expressions reveal many similarities between white and blue-collar employees within this organization as well as between these employees and those found in the published literature from workers in other industries. We discuss the implications of these findings for theory and future research.
Abstract 184: Radiation Exposure, an Important Quality of Care Measure for Physicians and Patients

Background: The risks of ionizing radiation to patients and physicians from radiographic procedures are a significant concern. Radiation is essential for the performance of cardiac catheterization and angioplasty but exposure should be minimized. Because it cannot be sensed and the effects may be delayed, radiation exposure must be measured and critically reviewed. Methods: The procedure volume, personal radiation exposure of interventional cardiologists at Stony Brook University Hospital was reviewed for 10 months from 1-10/11. The sensitivity of 3 measures of patient exposure: total dose (Kerma area product = P ka ), fluoroscopy time and skin dose were compared and the deep dose exposure of physicians was correlated with the number of incidents exceeding lab benchmarks for patient reportable excess radiation exposure. Results: During the monitored period a total of 1,978 cardiac catheterizations and 1,324 angioplasties [PCI] (>90% ad hoc) were performed by 14 interventional cardiologists. PCI volume averaged 94.6±54.6/ physician (range 28-180) and 40% of total lab volume (with ad hoc conversion rates from diagnostic catheterization ranging from 24% [72/303] -54% [180/332]). The average total deep dose/ physician was 787.5±710.6 mRem (high of 2,840). There were 187 incidents of total dose exceeding our benchmark of >20,000 microGray m 2 (14.1% [187/1,324] of PCI; 41 cases were > 30,000 and the highest procedural dose was 52,562). Excess fluoroscopy time (>60 minutes) was present in 5% (9/187) and excess skin dose (>5,000 milliGray) in 24% (12/51) of reportable cases of excessive total dose. Total and PCI volumes had Pearson correlation coefficients of 0.61 and 0.71 respectively with deep dose and 0.54 and 0.64 with patient total dose. Physician deep dose exposure had the best correlate (0.89) with reportable cases of patient exposure. Lifetime physician deep dose reflected case volume and years of practice, but exposure also varied markedly by physician, with average annual accumulations (mean 1,120.6 mRem/yr) ranging from 67 mRem/yr to 4,451.1 mRem/yr (the latter expected to limit the physician9s cath lab career to an additional 6 years at the current rate of accumulation based on maximal allowable lifetime dose). Conclusions: The high variability in operator exposure suggests significant variations in technique which should be further explored. Of the routine measures of exposure, the total dose is the most sensitive indicator of patient exposure. Operator and patient exposures are highly correlated. The high number cases exceeding benchmarks provide an opportunity for further drill down and procedural changes to optimize the risk/benefit ratio for both patients and operators.
Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease

Identifying which neuropsychological measures detect early cognitive changes associated with Alzheimer disease (AD), brain pathology would be helpful clinically for the diagnosis of early AD and for the design of clinical trials. We evaluated which neuropsychological measures in our cognitive battery are most strongly associated with cerebrospinal fluid (CSF) biomarkers of AD brain pathology. We studied a large cohort (n = 233) of middle-to older-aged community-dwelling individuals (mean age 61 years) who had no clinical symptoms of dementia and underwent baseline CSF collection at baseline. Participants completed a battery of 9 neuropsychological measures at baseline and then every 1 to 3 years. CSF tau/Aβ42 was associated with baseline performance on 5/9 neuropsychological measures, especially measures of episodic memory, and longitudinal performance on 7/9 neuropsychological measures, especially measures of global cognition. The free recall portion of the Free and Cued Selective Reminding Task (FCSRT-free) detected declining cognition in the high CSF tau/Aβ42 group the earliest, followed by another measure of episodic memory and a sequencing task.
Coming back to voice: The multiple voices and identities of mature multilingual writers

Abstract Compositionists often speak of the need to help students acquire a voice or identity in their writing. This interest in teaching voice is understandable but also problematic. Satisfactorily defining “voice,” especially from a second language (L2) point of view, is one of those problems. Another is a reliance on various conceptualizations that privilege a “Western” or a romantic or individualistic notion of voice in classroom situations where many students do not share such a background. In this paper, we use three case studies to address a third problem: a tendency in L2 writing instruction and research to overlook the voices, or identities, already possessed by L2 writers, many of whom at the graduate level bring a history of success as professional/academic writers in their native language and culture to the L2 writing classroom. We examine the role voice can play not as a teaching device but rather as a means by which to investigate and understand the voice-related issues these mature writers encounter in L2 contexts.
The Effect of Horse Velocity on the Output of an Inertial Sensor System

Abstract Horse velocity has previously been demonstrated to influence both subjective and objective evaluation of lameness, especially in horses with mild lameness. As horse velocity is not always tightly controlled either within or between successive lameness examinations and horse-mounted sensor systems are becoming more commonly used in clinical practice, it is important to understand the influence of horse velocity on the results of these sensor systems. One inertial sensor (IS) system is widely available and commonly utilized to complement the subjective lameness examination. The objective of this study was to determine if horse velocity had an effect on the kinematic output from this commercial IS system. Twelve horses with at least one lame limb were examined with the IS system during a single daily high-speed treadmill exercise session. Horses were examined at the trot at 3.0, 3.5, and 4.0 m/s, in random order. Stride rate, maximum and minimum differences in head position (HDMax, HDMin), vector sum (VS), and maximum difference in pelvic position (PDMax) and minimum difference in pelvic position (PDMin) were analyzed using mixed-model analysis of variance with significance at P P = .0025) and one variable of hindlimb lameness (PDMin) ( P = .0234). Horse velocity resulted in no significant differences on forelimb lameness kinematics (HDMax, HDMin, VS). Horse velocity may have an impact on assessment of hindlimb lameness as determined by this system, making it more important to control velocity in these cases.
Radiation enhanced MMP-9 dependent migration/invasion in hepatocellular carcinoma cell through PI3K/Akt/NF-kB or MAPK/ERK/NF-kB pathways

5691 A view of all three members of the p53 family (p53, p63, p73) is needed to understand how they may cooperate to carry out activities in tumor suppression and response to ionizing (IR) and ultraviolet B (UVB) radiation. We investigated the roles in cell cycle arrest and apoptosis response to DNA damage of the endogenous p53 family member proteins in genetically related initiated control (03C) and malignant (03R) mouse keratinocytes. The malignant 03R cells possess a wt p53 gene but defective p53 protein activities, reduced overall expression of p63 protein, and a striking loss of p73 protein. The DNA affinity immunoblotting assay [Liu et al., 2001; Knights et al., 2003] detected endogenous p53 family member binding in vitro to target DNA sequences of p21 (cell cycle arrest) and Noxa (apoptosis). p53 family member proteins from initiated 03C cells treated with either IR or UVB light bound strongly to the p21 and Noxa DNA probes. This binding correlated with an increase in p21 and Noxa mRNA (as analyzed by quantitative real-time PCR), and increased cell cycle arrest and apoptosis compared to the untreated control. In contrast, the IR treated malignant 03R cells exhibited reduced p53 family member DNA binding to p21 and Noxa probes, a lack of p21 or Noxa mRNA induction, failure to arrest in G1, and a lack of apoptotic response. Surprisingly, the IR-resistant 03R cells were sensitized to UVB-induced apoptosis. The UVB-induced apoptosis in 03R cancer cells and the apoptosis response of 03C initiated cells correlated with an increased binding to Noxa of p53 and p63 isoforms (putative TAp63 alpha and beta), and upregulation of Noxa mRNA expression. Furthermore, following DNA damage, increased p63 binding to the Noxa binding site coincided with decreased p73 isoforms binding to Noxa. We will selectively modulate expression of p53 family member isoforms to explore the idea that specific isoforms of p63 and p73 coordinate with p53 in binding to cell cycle and apoptosis-related promoters to determine cell fate and may restore cell cycle arrest and apoptotic response in malignant cells. Insight into p53 family members’ roles in the etiology of radiation response in epithelial cancer development could suggest new therapeutic approaches to IR radiation-resistant human solid tumors of epithelia. Supported by NCI CA31101, CA98893, OHSU Cancer Institute CA69533, Medical Research Foundation of Oregon, the Tartar Trust Fellowship, and the Department of Dermatology, OHSU.
Identification and inhibitory activities of ellagic acid- and kaempferol-derivatives from Mongolian oak cups against α-glucosidase, α-amylase and protein glycation linked to type II diabetes and its complications and their influence on HepG2 cells’ viability

Abstract This study was to characterize phenolic composition of 50% ethanol crude extract (ECE) by UPLC-QTOF-MS/MS and to investigate anti-diabetic activities of the ECE and its four fractions from Mongolian oak cups. The results show that 24 phenolics were identified from the ECE, and ellagic acid (EA)- and kaempferol-derivatives were the main phenolic components in oak cups. Dominant constituents in each of the four fractions were subsequently characterized by HPLC fingerprints. Acid hydrolysis exhibited that oak cups contained both ellagitannins and gallotannins, and ellagitannins were the dominant hydrolysable tannins. Furthermore, ECE and its four fractions exhibited much more drastic inhibitory activities against α-glucosidase than α-amylase, and formation of advanced glycation end-products was inhibited differently by ECE and Frs I-IV. Overall, EA- and kaempferol-derivatives in oak cups were the main anti-diabetic contributors, and EA-derivatives exhibited superior inhibition against α-glucosidase and glycation while kaempferol-derivatives showed stronger α-amylase inhibitory activity. In addition, Frs I-IV affected cell viability differently and kaempferol-derivatives in Fr. IV resulted in its highest anticancer activity. Aforementioned results first indicated that oak cups, being underutilized plant byproducts, should be a novel dietary phytonutrient for diabetes management with inhibitory activities against α-glucosidase, α-amylase and formation of AGEs, as well as for cancer treatment.
Morbidity, Disability, and Mortality

Publisher Summary This chapter reviews some major directions and findings from recent research on morbidity, disability, and mortality among adults and the elderly. One of the findings is that during the last two decades of the 20th century, the United States continued to exhibit shifts in the age distribution of both overall deaths and deaths from major degenerative diseases toward older ages. This is consistent with predictions from the fourth stage of the epidemiologic transition—the age of delayed degenerative diseases. Research on the dynamics of morbidity and mortality in medical demography shows that the age dependence of mortality risk can be substantially reduced or explained by taking into account several measures of physiological functioning. If the therapies have the effect of helping a larger fraction of elderly cohorts maintain their physiological parameters near the optimal values, this could reduce the age dependence of mortality and further raise life expectancy, which has implications for forecasts of the size and health status of the elderly population that are based on the medical demography model. Research in social demography, epidemiology, and medical sociology has greatly improved knowledge of how social, economic, and lifestyle/behavioral factors affect differentials in morbidity, disability, and mortality by sex, race/ethnicity, and socioeconomic status.
Stability of Repackaged Products

For better patient compliance and easier distribution, some drug products are frequently repackaged from their original containers into unit-dose packages by pharmacists or commercial repackagers. The USP indicates that for non-sterile solid dosage forms packaged in unit-dose containers, the beyond-use date shall be 1 year from the date the drug is packaged into the unit-dose container or the expiration date on the manufacturer’s container, whichever is earlier, unless stability data or the manufacturer’s labeling indicates otherwise. Due to differences in moisture permeation, thermal susceptibility or surface chemistry of the new packaging material when compared to the original, the stability of a repackaged drug product can differ from that ­obtained from original container. This concern prompted us to study the stability issues associated with certain repackaged products. This chapter will highlight some of the findings in our research laboratory.
Using modified Lasso regression to learn large undirected graphs in a probabilistic framework

Learning the structures of large undirected graphs with thousands of nodes from data has been an open challenge. In this paper, we use graphical Gaussian model (GGM) as the underlying model and propose a novel ARD style Wishart prior for the precision matrix of the GGM. which encodes the graph structure we want to learn. With this prior, we can get the MAP estimation of the precision matrix by solving (a modified version of) Lasso regressions and achieve a sparse solution. We use our approach to learn genetic regulatory networks from genome-wide expression microarray data and protein-binding location analysis data. Evaluated on the basis of consistency with the GO annotations, the experiments show that our approach has a much better performance than the clustering-based approaches and BN learning approaches in discovering gene regulatory modules.
Conduct Unbecoming a Coordinate Branch: The Supreme Court in Garrett

In this essay, the authors analyze the Supreme Court's decision in Board of Trustees of the University of Alabama v. Garrett, where the Court last term held that the employment provisions (Title I) of the Americans With Disabilities Act were not a valid exercise of Congressional power under Section 5 of the Fourteenth Amendment. The authors argue that whether or not earlier cases from the Court in the 1990's construing Congress' section 5 power narrowly were correctly decided, the Court in Garrett makes a number of questionable analytic moves that demonstrate a disrespect for Congress' constitutional role in vindicating equal protection rights. In particular, the authors argue that the Court's treatment of earlier equal protection caselaw in the disability arena, its treatment of Congress' fact-finding record and the inferences Congress could draw from that record, and its treatment of who should count as a state wrongdoer for purposes of Congress' section 5 power are all unworthy of the Court.
Resource to Share with Parents: Helping Your Child Develop Physical Literacy

Research has shown that children's levels of physical activity are set at an all-time low, which can lead to health problems such as obesity and diabetes. So, what can parents do to ensure that the...
MineBike: Exergaming with Minecraft

Exergaming has drawn attention for years as a health benefactor that can contribute to public health improvement. Studies have shown that it can result in immediate health benefits. However, it has also been shown that current exergames do not have the staying power to bring players back for long-term use - the benefits tend to be short term with players initial excitement waning over time. The obvious conclusion is that current exergames are not designed with long-term challenges as their underlying game design criterion. To address the issue, we looked into adapting an existing popular game, with proven staying power, to an exercise bike. In a preliminary study that we conducted, we showed that children took very well to MineBike, an exergaming experience we developed using the popular game Minecraft. However, we also observed that to encourage the children to pursue a physical activity of consistent intensity we had to incorporate ongoing in-game challenges. In this paper, we specifically address the issue of embedding exergaming experiences in a popular game to enhance the staying power for sustained physical activity. We describe game design elements that can create the immersive exergaming experience that encourages mid- to high-level exercise intensity.
Dual Polarized Wideband Vivaldi 4x4 Subarray Antenna Aperture for 5G Massive MIMO Panels with Simultaneous Multiple Beams

In this paper, a wideband dual linear polarized Vivaldi 4x4 sub-array antenna aperture with low mutual coupling is analyzed for its impedance matching and radiation performance. This antenna also provides good polarization isolation to support simultaneous transmit and receive communications as desired in 5G communications. This array can be used as a base station panel for the Massive Multiple Input Multiple Output (MIMO) array. In addition, Keysight SystemVue tool has been used to generate digital beamforming (DBF) approach based simultaneous multiple beams.
190) Perceived Control over Chronic Pain in African American Adults Living in Urban Detroit

The purpose of this qualitative study was to describe experiences of urban cumulative trauma exposure and the relationship to chronic pain in African American adults. The study investigated whether lack of control over traumatic experiences while living in an urban area lead to a decreased perceived control over pain. Qualitative methodology was chosen due to limited literature available linking those with a history of cumulative trauma to perceived control over adulthood chronic pain. Descriptive, qualitative design utilizing open-ended interviewing was used to seek a more in depth understanding of the relationship between cumulative trauma in the urban environment and perceived control over pain in adults with chronic pain. Inclusion criteria: (1) self-identified African American ethnicity; (2) experiencing chronic pain (3) adults age 19 or older; (4) resided in an urban setting as youth; (5) experienced cumulative urban trauma. Saturation was reached after in-home interviews with 12 participants. Participants did not perceive trauma despite descriptions of neighborhood crime, neglect, racial segregation, and feelings of fear and decreased control over the neighborhood, suggesting neighborhood disorder to be more applicable to this population than cumulative trauma. Despite reporting pain scores of 6 to 10 on a 0-10 scale, participants believed their pain was controllable and well as controlled. Pain interfered significantly with all activities, with general activity, walking, and relations with others being the most affected. Associations were found between the stress of neighborhood disorder, perceived control over pain and life in general. The relationship between neighborhood disorder and perceived control over pain may aid in addressing existing pain disparity in African Americans residing in impoverished urban neighborhoods.