cssi/SciSciGPT-SciSciNet huggingface dataset:
From Disgust to Humor: Rahab’s Queer Affect

This paper argues that contemporary disgust toward nonheteronormative sexuality in the U.S. is conditioned by racialized representations of Canaanite sexuality in the Bible, even where that biblical heritage is no longer obvious. Using queer theory and recent cultural studies analyses on affect, it suggests that the well-recognized humor in the story of Rahab in Joshua 2 might intervene in the usual circuits of disgust. A humorous earlier indigenous tale can be discerned that undercuts the affective values of the story’s colonial final form, especially as they circulate around the Canaanites, the divine warrior, holy war, and even Rahab’s own heroism. It is in the final form of the story, however, that Rahab is the most queer. Though resistant, she is neither fully transgressive or heroic, but she is funny. That hilarity revalues the usual emotive response to Canaanite sexuality, allowing affective bodily energies to turn the repulsion of disgust into the inclusion of pleasure.
Qualifying for Incentive Payments for Meaningful Use of Health Care IT for Radiologists: Practical Initial Steps

The last installment of “Bits and Bytes” [1] described some of the basic components of “meaningful use” (MU), briefly outlining the Health Information Technology for Economic and Clinical Health (HITECH) Act signed by President Obama into law in February 2009 and its broad goal of helping improve health care by accelerating the adoption and use of health care IT (HIT) [2]. To achieve this goal, the federal government will provide short-term CMS incentive payments to eligible providers (EPs) who become meaningful users of certified HIT and, ultimately, CMS penalties for EPs who do not meet the requirements of MU [3]. Meaningful use will be implemented in 3 phases, with phase 1 beginning in 2011, phase 2 beginning in 2013, and phase 3 beginning in 2015. Although phase 1 requirements have been issued, the requirements for the later phases have not yet been established. The maximum potential CMS financial incentive per EP is $44,000 over 5 years. Radiologists are EPs for MU and the ACR estimates that more than 85% of radiologists will qualify for incentive payments. This means that radiologists are also eligible for later financial penalties if they do not become meaningful users of certified HIT by 2015. Below, we suggest some practical initial steps you should take in your practice to prepare to qualify for MU. The initial question is whether your practice should plan to qualify for MU. The maximum potential financial incentive per EP ($44,000 over 5 years) seems substantial at first glance. However, it is highly unlikely that these incentive payments will provide adequate resources to acquire and implement the technology and process changes necessary for radiologists who qualify for MU over the next 5 years. Thus, MU can be best seen as a partially funded federal mandate. Despite the inadequacy of the resources provided by CMS for MU, the ambiguity of phase 1 MU requirements, and the uncertainty of future MU requirements, we believe that it is important for radiologists to work diligently to qualify as meaningful users of HIT. Health care reform is a major national priority, and HIT provides crucial tools to improve the quality and efficiency of health care services. Radiology as a specialty has historically been a leader in the adoption of IT tools. But recognizing that the promise of HIT has yet to be fully realized, as physicians and citizens, we must do our part to qualify for phase 1 MU requirements. Perhaps even more important, we must actively participate in the process of defining phase 2 and phase 3 MU requirements relevant to our specialty. Below are some specific initial steps you can take to prepare to qualify for MU requirements.
Analysis of temporal gene expression profiles: clustering by simulated annealing and determining the optimal number of clusters.

Motivation: Cluster analysis of genome-wide expression data from DNA microarray hybridization studies has proved to be a useful tool for identifying biologically relevant groupings of genes and samples. In the present paper, we focus on several important issues related to clustering algorithms that have not yet been fully studied. Results: We describe a simple and robust algorithm for the clustering of temporal gene expression profiles that is based on the simulated annealing procedure. In general, this algorithm guarantees to eventually find the globally optimal distribution of genes over clusters. We introduce an iterative scheme that serves to evaluate quantitatively the optimal number of clusters for each specific data set. The scheme is based on standard approaches used in regular statistical tests. The basic idea is to organize the search of the optimal number of clusters simultaneously with the optimization of the distribution of genes over clusters. The efficiency of the proposed algorithm has been evaluated by means of a reverse engineering experiment, that is, a situation in which the correct distribution of genes over clusters is known a priori. The employment of this statistically rigorous test has shown that our algorithm places greater than 90% genes into correct clusters. Finally, the algorithm has been tested on real gene expression data (expression changes during yeast cell cycle) for which the fundamental patterns of gene expression and the assignment of genes to clusters are well understood from numerous previous studies. Availability: The source code of the program implementing the algorithm is available upon request from the authors.
The Role of Leukocytes in Ethchlorvynol-Induced Pulmonary Edema

Intravenous administration of ethchlorvynol (Placidyl) is known to produce noncardiogenic pulmonary edema in animals and humans. Since intrapulmonary sequestration of leukocytes has been observed to occur following injection of ethchlorvynol, we evaluated the role of these elements of the blood in producing pulmonary edema. In vivo studies in dogs showed intrapulmonary trapping of leukocytes, as evidenced by increasing leukocyte differences between blood from the pulmonary artery and arterial blood. In both animals with normal leukocyte counts and those depleted of leukocytes (
Regional Government and Governance in China and the United States

A comparative analysis of regional governance policies in China and the United States is presented from multiple perspectives, including jurisdictional structure, intergovernmental relationship, and performance outcomes. Policy reviews and case studies contrast how regional approaches may assist governments to learn seminal lessons from multinational experiences.
Residual Stress Extraction of Surface-Micromachined Fixed-Fixed Nickel Beams Using a Wafer-Scale Technique

This paper reports on the extraction of residual stress in surface-micromachined nickel thin films of electrostatically actuated fixed-fixed beams using a wafer-scale technique. The distribution of residual stress for 87 beams on a 4-in quarter wafer piece is presented. The residual stress ( $\sigma _{0}$ ) is determined from the best fit of the displacement-voltage curves predicted by a computationally efficient model to the experimental data. The nondestructive and automated measurements are taken at room temperature and directly at the beam itself without any additional test structures. The model employed incorporates the nonideal effects of inclined supports, nonflat initial beam profiles, and fringing fields. The extracted residual stress values vary between −12.8 and 13.6 MPa (negative values are for compressive stresses and positive ones for tensile stresses). The residual stresses for these 87 beams follow a nearly normal distribution with a mean value of −1.7 MPa and a standard deviation of 5.9 MPa, which represents the variability of the residual stresses across the wafer. Detailed uncertainty analysis has been conducted, and it reveals that inaccurate modeling of the nonideal effects will result in significant errors in the extracted residual stress. Although demonstrated on nickel thin films, this technique can be applied to other metallic thin films. [2014-0344]
Multimodal Molecular Imaging Reveals High Target Uptake and Specificity of 111In- and 68Ga-Labeled Fibrin-Binding Probes for Thrombus Detection in Rats

We recently showed the high target specificity and favorable imaging properties of 64Cu and Al18F PET probes for noninvasive imaging of thrombosis. Here, our aim was to evaluate new derivatives labeled with either with 68Ga, 111In, or 99mTc as thrombus imaging agents for PET and SPECT. In this study, the feasibility and potential of these probes for thrombus imaging was assessed in detail in 2 animal models of arterial thrombosis. The specificity of the probes was further evaluated using a triple-isotope approach with multimodal SPECT/PET/CT imaging. Methods: Radiotracers were synthesized using a known fibrin-binding peptide conjugated to 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid (NODAGA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid monoamide (DOTA-MA), or a diethylenetriamine ligand (DETA-propanoic acid [PA]), followed by labeling with 68Ga (FBP14, 68Ga-NODAGA), 111In (FBP15, 111In-DOTA-MA), or 99mTc (FBP16, 99mTc(CO)3-DETA-PA), respectively. PET or SPECT imaging, biodistribution, pharmacokinetics, and metabolic stability were evaluated in rat models of mural and occlusive carotid artery thrombosis. In vivo target specificity was evaluated by comparing the distribution of the SPECT and PET probes with preformed 125I-labeled thrombi and with a nonbinding control probe using SPECT/PET/CT imaging. Results: All 3 radiotracers showed affinity similar to soluble fibrin fragment DD(E) (inhibition constant = 0.53–0.83 μM). After the kidneys, the highest uptake of 68Ga-FBP14 and 111In-FBP15 was in the thrombus (1.0 ± 0.2 percentage injected dose per gram), with low off-target accumulation. Both radiotracers underwent fast systemic elimination (half-life, 8–15 min) through the kidneys, which led to highly conspicuous thrombi on PET and SPECT images. 99mTc-FBP16 displayed low target uptake and distribution consistent with aggregation or degradation. Triple-isotope imaging experiments showed that both 68Ga-FBP14 and 111In-FBP15, but not the nonbinding derivative 64Cu-d-Cys-FBP8, detected the location of the 125I-labeled thrombus, confirming high target specificity. Conclusion:68Ga-FBP14 and 111In-FBP15 have high fibrin affinity and thrombus specificity and represent useful PET and SPECT probes for thrombus detection.
Republicanism at Work: Strategies for Supporting Resistance to Domination in the Workplace

Work, as organized in contemporary workplaces and situated in social and political structures, poses a threat to freedom that has been under-appreciated in political theory, especially liberal political theory. The recent revival of republicanism offers an intriguing alternative-can republicanism do any better, with respect to work and freedom? An examination of the workplace through a republican lens does a better job of helping us make sense of the way work threatens freedom–by exposing us to the threat of domination--and it can generate at least three plausible proposals that might render resistance to domination in the workplace more successful: enhanced exit, workplace constitutionalism, and workplace democracy. But this is here where republican political theory leaves us. In order adjudicate between these strategies, as well as identify positive goals to accompany the avoidance of domination, we must turn to democratic theory, and pay closer attention to how workers, as a distinct subset of the population, pursue the project of enhancing and protecting freedom in the workplace. This examination makes clear that a missing concept in neorepublican theory is resistance--workers seeking non- domination through their own initiatives. Once this modification is made, the relative importance of workplace democracy for securing non-domination becomes clearer.
Combining ablation of atrial fibrillation with ablation of atrial flutter: are we there yet?*

Atrial fibrillation (AF) and atrial flutter can coexist. Their association is of particular concern when considering curative ablation. Symptoms, similar for both, are disconcerting should either one occur after ablation. Complete cure is the goal. Right atrial (cavo-tricuspid isthmus) ablation can
ETS1 inactivation causes innate drug resistance to EGFR inhibitors

Mutations in epidermal growth factor receptor (EGFR) are found in approximately 10% of lung cancers. Treatment with EGFR inhibitors, although promising, has surprisingly resulted in greater than 90% tumor reduction in only 5% of cases, prompting us to investigate the mechanism of innate drug resistance.
In Pursuit of the Happy Transit Rider: Dissecting Satisfaction Using Daily Surveys and Tracking Data

This paper demonstrates the power and value of connecting satisfaction surveys from public transportation passengers to smartphone tracking data and automatic vehicle location (AVL) data. The high resolution of the smartphone location data allows travel times to be dissected into their individual components, and the connection with AVL data provides objective information on personal-level experiences of the respondents. Analyses show how these data can provide a quantitative understanding of the relationship between planned and provisioned service, and customer satisfaction. In-vehicle travel time data from 2,403 trips made by 529 unique participants could be obtained, along with origin wait time data for 779 of the trips and transfer time data for 188 trips. The addition of unreliability to the measurement of travel times, which is enabled by the highly detailed tracking data, shows that the relationship between passenger satisfaction and experienced travel times may be more nuanced than has previously b...
Microanalytical Methodology Relating to the Identification of Insect Sex Pheromones and Related Behavior-Control Chemicals

Methods currently in use in the extraction, isolation, and identification of insect sex attractants, which are needed for use in pest control, are described briefly. Because amounts of these materials in insects are generally minute, specialized microanalytical methods and techniques have been developed to aid in the determination of their chemical structures.
A Study of Self-Concept of Hearing-Impaired Students as Compared to the Self-Concept of Normal-Hearing Students

A STUDY OF SELF-CONCEPT OF HEARING-IMPAIRED STUDENTS AS COMPARED TO THE SELF-CONCEPT OF NORMAL-HEARING STUDENTS
Diagnostik und Therapie des Hyperinsulinismus

Der Hyperinsulinismus bei 47 Patienten wurde klinisch und durch Blutzucker-, Insulin- und C-Peptidmessungen gesichert. Die praoperative Lokalisation eines Insulinoms war zu 60% mit der Angiographie, zu 50% mit der CT-Untersuchung und in nur 10% mit der Sonographie erfolgreich. Die intraoperative Tumorlokalisation mit der szintigraphischen Messung von inkorporiertem P32 gelang in 70% der Falle. Bei 37 Patienten enukleierten wir ein oder mehrere Adenome. Bei 5 Kindern mit einer Neosideoblastose erfolgte die Pankreasteilresektion. Bei 5 Patienten mit einem Inselzellkarzinom fuhrten wir eine Resektion und Chemotherapie durch.
Numerical modeling of ventilated wall cavities with spray evaporative cooling system

Abstract Envelope systems are the main contributors to the energy consumption associated to cooling or heating buildings. There have been significant research efforts to improve the performance of building envelope systems by integrating passive cooling strategies to reduce cooling loads and maintain acceptable indoor thermal comfort. The ventilated wall cavity system is one of these passive-cooling strategies that have received considerable attention recently due to the significant benefits of reducing thermal loads of buildings. In particular, evaporative cooling inside ventilated wall cavities is an attractive passive cooling technique especially in hot and dry climates. This paper presents the initial findings of a current research study focusing on improving the ventilated wall cavity with spray evaporative cooling system that produce fine water droplets. Specifically, this paper describes a numerical modeling approach to evaluate the performance of the proposed passive cooling system to cool buildings in hot and dry climates. The simulation results suggest that a significant reduction in cooling loads can be achieved since the wall cavity can absorb heat from the indoor and outdoor while inducing acceptable supply air temperature capable of maintaining indoor thermal comfort within buildings.
Riskier Business: Atrial Fibrillation Stroke Prevention in the CHA2DS2-VASc Era.

During the past decade, 2 substantial advancements in atrial fibrillation (AF) management have shifted the clinical paradigm for thromboembolic risk reduction. The introduction and validation of the CHA2DS2-VASc score resulted in a refined clinical understanding of AF stroke risk, particularly among individuals identified as having a low risk of thromboembolism by the previously embraced CHADS2 score.1 The popularity of CHA2DS2-VASc quickly grew, and current AF management guidelines recommend this algorithm for AF stroke risk assessment and decision making.2,3 At the same time, new medications (and devices) became available as alternatives to warfarin for prevention of thromboembolism. Although anticoagulation with warfarin has long stood as the cornerstone of AF-associated stroke prevention, the drawbacks of this treatment have been well recognized. Direct oral anticoagulant (DOAC) therapy has emerged as an efficacious and safe anticoagulation strategy that eliminates many of the inconveniences and some of the risks imposed by vitamin K antagonism.4 The temporal proximity of these advances in anticoagulation and stroke risk stratification was fortuitous; as the CHAD2DS-VASc score identified a new cohort of previously low-risk patients now at sufficient stroke risk to warrant anticoagulation, DOAC therapy overcame many of the perceived barriers to warfarin use. See Article …
Adaptive Estimation Using Multiple Models and Neural Networks

Abstract A method is presented to combine multiple model estimation with a neural network to obtain more accurate estimates. The key idea is to use the data from the initial phase of the run for system identification, and then run a single estimator designed for the identified model for the remainder of the run. The use of multiple models and neural networks allows the on-line identification to take place extremely quickly. The method is validated on actual data from an important estimation problem in microelectronics manufacturing which is subject to model uncertainties: determining end-point to an etch step using reflectometry data.
A comparative study of the liberal arts tradition and Confucian tradition in education

In contrast to the continued decline and bleak future of liberal arts education and liberal arts colleges in Europe and America, there has been a revival of the liberal arts model in Asian countries in recent years. This paper compares the liberal arts tradition of education in the West and Confucian tradition of education in the East, in the aspects of educational goal, curriculum, and pedagogy, as well as the way both traditions are institutionalized. It makes connections between these humanistic approaches to demonstrate the common ground for the education of mankind: human beings need to develop meaning for life and to be able to relate to others in order to have a fulfilling life, and highlights the importance of such humanistic approaches as liberal arts education and the Confucian tradition in an increasingly utilitarian and vocation-oriented world.
Direct experimental evidence for a metastable state of deuterium fluoride (D2F), an analog of deuterium oxide D3O)

The D/sub 2/F radical has been studied by a combination of neutralized ion beam and charge stripping techniques. Neutrals formed by D/sub 2/SF/sup +//Na charge exchange are observed in metastable and dissociative states. The lifetime of metastable D/sub 2/F is greater than 0.4 ..mu..s. Metastability is not observed for HDF or H/sub 2/F. The dissociative state of D/sub 2/F releases about 1.9 eV of kinetic energy in its fragmentation products (DF + D). The vertical electron affinity of H/sub 2/F/sup +/ is calculated to be 6.6 +- 0.2 eV. The possibility of observing an emission continuum from electronically excited H/sub 2/F formed by H/sub 2/F/sup +//K charge exchange is suggested. Similarities in the mass spectra of D/sub 2/F and the isoelectronic D/sub 3/O radical are indicated.
The role of signal transduction pathways in drug and radiation resistance.

“MAPK” was first reported by Sturgill and Ray in 19861;. This protein kinase was originally described as a 42-kDa insulin-stimulated protein kinase activity whose tyrosine phosphorylation increased after insulin exposure, and which phosphorylated the cytoskeletal protein MAP-2 (hence “MAP” kinase). Contemporaneous studies by Boulton and Cobb identified an additional 44-kDa isoform of MAPK, which they named ERK1 (extracellular signal regulated kinase)2. Since many growth factors and mitogens could activate MAPK, the acronym for this enzyme has subsequently been considered to denote mitogen-activated protein (MAP) kinase. In the following years, additional studies demonstrated that the p42/p44 MAPKs regulated another protein kinase activity (p90rsk)3and that they were themselves regulated by a protein kinase activity originally designated MKK (MAPK kinase)4’5
PROCESSING OF OLFACTORY STIMULI AT PERIPHERAL LEVELS

Based upon his electrophysiological work during the early 1950’s, Adrian (1950, 1951, 1953, 1954) has left a legacy concerning the mechanisms which might underlie olfactory discrimination at the level of the olfactory mucosa. One such mechanism involves the selective sensitivity of individual receptor cells to particular odorants or groups of odorants. Any given cell would not be equally sensitive to all odorants, but would instead be maximally excited by some odorants and excited less, or not at all, by others. Thus, each receptor cell would signal the degree to which its particular sensitivity is matched by the molecules of incoming odorants.
Perspectives on the Asymptotic Geometry of the Hitchin Moduli Space

We survey some recent developments in the asymptotic geometry of the Hitchin moduli space, starting with an introduction to the Hitchin moduli space and hyperkahler geometry.
A massively-parallel, unstructured overset method for mesh connectivity

Abstract We present a method that dynamically and efficiently performs connectivity calculations between many ( O ( 10 5 ) ) moving, unstructured overset meshes in parallel. In order to connect overset meshes, elements exterior to the solution domain must be removed from the simulation. In regions with many overlapping meshes, elements must be selectively removed to reduce redundancy while maintaining a solution over the entire domain. Around masked regions interpolation partner pairing is required between meshes to provide boundary conditions. For general unstructured meshes, these steps involve challenging computational geometry calculations which must be efficient and automatic. For many moving meshes each step must be massively parallelized and scalable to large numbers of computational cores. To establish communication patterns a parallelized master/slave algorithm is used which minimizes global communication and storage. To remove elements a parallel ‘Forest Fire’ flood-fill algorithm is used to set a masking variable. For interpolation partner pairing, and other necessary searches, k-dimensional tree data structures (k-d trees) are extensively used. Often in a calculation, the connectivity between overset meshes remains largely the same between time steps. The temporal coherence of the various objects in the connectivity calculation is directly used to only update necessary information with time, resulting in substantial cost savings. Details of the different algorithms are presented. Resulting connectivity and timings are shown for complex geometries. Parallel scaling is demonstrated for 100,000 spherical particles within a channel up to 492,000 processors.
DE-Crawler: a densification-expansion algorithm for online data collection

Over the past two decades, online social networks have attracted a great deal of attention from researchers. However, before one can gain insight into the behavior or structure of a network, one must first collect appropriate data. Data collection poses several challenges, such as API or bandwidth limits, which require the data collector to carefully consider which queries to make. Many network crawling methods have been proposed; however, their performance depends on network structure. In particular, our previous work in [1] has shown that existing algorithms tend to either (1) Do well at exploring dense areas of a network, but have difficulty in transitioning to new areas of the network, or (2) Easily move between network regions, but fail to fully explore each region. In this work, we introduce DE-Crawler, a novel network crawler that attempts to capture the best of both worlds. DE-Crawler consists of two main stages: Densification, in which the crawler aims to find as many nodes as possible in the current dense region (or community), and Expansion, in which the crawler tries to escape from its current region and move to another dense region. We show that DE-Crawler performs well across networks with different structural properties, outperforming baseline algorithms by up to 28%.
Spontaneous Bacterial Peritonitis

Spontaneous bacterial peritonitis (SBP) is a common and potentially fatal infection of ascitic fluid in patients with cirrhosis. It is distinguished from secondary peritonitis by the absence of an evident intra-abdominal surgically treatable source. The prevalence of SBP is 10–30% in hospitalized patients with cirrhosis and ascites. Patients may present with symptoms such as abdominal pain, altered mental status, or fevers and chills. However, patients are often asymptomatic. In this chapter, we describe a case of SBP and discuss pathophysiology, diagnosis, treatment options, and outcomes.
Bioethics in the United States: 1989–1991

This report provides a summary and analysis of recent developments in bioethics in the United States on numerous topics. Its discussion has been organized according to eight broad areas. Section II reports on recent cases implicating several issues: the right to refuse medical treatment, the meaning of medical futility, and the legitimacy of physician-assisted suicide. Section m discusses recent cases involving abortion, including Webster and Rust V. Sullivan, as well as recent public policy decisions to ban the importation of the abortifacient pill RU-486. Section IV analyzes issues posed by the new reproductive technologies, including recent cases involving surrogate motherhood and the disposition of frozen embryos. Section V summarizes recent cases of maternal-fetal conflicts that raise questions about the legitimacy of courtordered medical treatment, the appropriateness of prosecution for fetal abuse, and the status of fetal protection policies in the workplace. Section VI analyzes several ethical and legal issues raised by AIDS, including the propriety of notifying third parties, appropriate policies on HIV testing, and the challenges to health insurance posed by the AIDS epidemic. Section VII discusses topics in genetics, including issues of property rights posed by genetic engineering, and questions of appropriate guidelines in the management of genetic information.Section VIII traces recent proposals for health care financing reform, including the Oregon Basic Health Services Act, the “Health Access America” plan of the American Association, the recommendations of the Pepper Commission, and the proposal offered by Physicians for a National Health Program. Finally, Section IX discusses recent discussion concerning the regulation of professional conduct, especially regarding relations between Physicians and th Parmaceutical industry, and problem of sexual misconduct between physicians and their patients.
Passive Elbow Movement Assistant (PEMA): A portable exoskeleton to compensate angle-dependent tone profile of the elbow joint post-stroke

Significant impairments in upper extremity function are commonly observed after neurological injuries such as stroke. While the efficacy of robotic training has been demonstrated, the use of these devices is confined to the laboratory setting due to its complexity and power requirements. In this study, we developed a passive, portable device (Portable Elbow Movement Assistant; PEMA) that can provide assistance during elbow movements of stroke survivors. The geometric properties of the device were designed to allow morphological changes in the elastic components during movements, so that the assistance produced by the elastic component counteract the angle-dependent flexor hypertonia commonly observed in stroke survivors. A mathematical model for the proposed design was first developed to characterize the assistance provided by the device. The capacity of the device was then tested in a pilot testing with four healthy subjects, for whom a custom device to simulate elbow flexor hypertonia (providing an increased resistance for the extended posture) was implemented. The proposed device was found to effectively counteract the angle-dependent flexion moment, produced by the hypertonia simulator, as a significant decrease was observed in the slope of the angle-activation relationship (movement phase) and activation level (hold phase) of the triceps brachii muscle. The assistance did not affect the activation of the antagonist muscle (biceps brachii), indicating an independent modulation of the agonist and antagonist muscles resulted from the assistance.
Finding purpose and happiness after recovery from suicide ideation

ABSTRACTAlthough most individuals who experience suicidal thoughts will never attempt suicide and the majority of those who survive a suicide attempt will neither re-attempt nor die by suicide, lit...
Predicting epiphyseal stability of slipped capital femoral epiphysis with preoperative CT imaging

Abstract Background We analyzed preoperative CT scans of hips with slipped capital femoral epiphysis (SCFE) for characteristics that could be predictive of intraoperative epiphyseal stability and d...
Current methods for assessing technical skill in cataract surgery.

Surgery is a major source of errors in patient care. Preventing complications from surgical errors in the operating room is estimated to lead to reduction of up to 41,846 readmissions and save $620.3 million per year. It is now established that poor technical skill is associated with an increased risk of severe adverse events after surgery and traditional models to train surgeons are being challenged by rapid advances in technology, an intensified patient-safety culture, and a need for value-driven health systems. This review discusses the current methods available for evaluating technical skills in cataract surgery as well as the recent technological advancements that have enabled capture and analysis of large amounts of complex surgical data for more automated objective skills assessment.
Terahertz spectroscopy and imaging: A review on agricultural applications

Abstract Terahertz (THz) waves are non-ionizing radiations with unique properties of both microwave and infrared. THz imaging and spectroscopy have been widely used for non-destructive testing, security screening, medical imaging, and quality control both in the agricultural and food industries. This review briefly describes the principles of how THz is generated, discusses its current agricultural applications and highlights the research gaps. THz spectroscopy has primarily been used for measuring the water content of plant leaves. Later, it was used to detect dead and live insects and pests in agricultural products. A combination of THz spectroscopy with chemometric methods, machine learning, and search algorithms helped scientists to construct classification models for discrimination of transgenic seeds, pesticides, harmful compounds, and poisonous plants. THz spectroscopy has also been used for soil inspection and detection of heavy metals and buried objects. In recent years, there have been significant technological improvements in developing THz sources and detectors, which enabled researchers to perform ultra-fast scanning and obtain high-resolution images. Using these new THz technologies, researchers can differentiate between fresh and old leaves, monitor the water status of plants, and estimate the crop yield. Although THz has proved to be a useful tool for non-destructive quality control of agricultural products and soil inspection, the technique has some limitations such as a low limit of detection (LOD) for pesticides, low spatial resolution, and limited penetration. It can also be influenced by the physical properties of samples such as particle size, and surface roughness. On the sensor side, more research is needed to improve the performance of THz systems, reduce THz sensor costs and ruggedness of the system for applications in agriculture. Also, more research is required to explore new potential applications of this technology in agriculture.
Investigating the effect of electric fields on lead halide perovskites by scanning tunneling microscopy

Lead halide perovskites have emerged as promising absorber materials over the last decade to increase the efficiency of photovoltaics beyond its current limits. However, to further optimize the performance of perovskites more detailed studies need to be performed, which allow for the correlation of film morphology and local electronic properties at the nanoscale. Here, we present a scanning tunneling microscopy (STM) approach to probe the effect of an applied electric field of a methylammonium formamidinium lead triiodide perovskite thin film on the film response by current–voltage spectroscopy, current imaging tunneling spectroscopy, differential conductance mapping, and x-ray absorption spectroscopy by means of synchrotron x-ray STM. We find a strong correlation between the measurement conditions and the obtained current–voltage characteristics when imaging under opposite bias polarities. In particular, we find similarities to already observed poling effects for lead halide perovskites, which result in either a positively or negatively charged interface due to ion and vacancy migration. Our results provide insight into the influence of measurement conditions such as bias polarity on the performance assessment of perovskite thin films by STM.
Women's Preventive Services Initiative recommends screening women for anxiety.

SOURCE CITATION Gregory KD, Chelmow D, Nelson HD, et al. Screening for anxiety in adolescent and adult women: a recommendation from the Women's Preventive Services Initiative. Ann Intern Med. 2020;173:48-56. 32510990.
Impact of higher oxygen saturation levels on postnatal weight gain to predict retinopathy of prematurity

Retinopathy of prematurity (ROP) is the leading cause of vision loss in children. A well-known risk factor for the development of ROP is duration of oxygen supplementation. Other postnatal factors have also been associated with ROP risk, including poor post-natal weight gain. The weight, insulin-like growth factor, neonatal retinopathy of prematurity (WINROP) algorithm predicts severe ROP based on postnatal weight gain and has been validated in several studies,1,2 including a high sensitivity for prediction of severe ROP in our local NICU populations. However, target oxygen saturation levels were subsequently increased in many NICUs based on results from the Neonatal Oxygen Prospective Meta-analysis (NeOProM) Collaboration, which showed statistically higher death and disability rates among preterm infants randomized to a lower oxygen-saturation target range (85 - 89%) versus a higher target range (91 - 95%),3 which may affect the incidence and severity of ROP4 as well as the validity of the WINROP algorithm. In 2018, Lundgren et al reported that the WINROP algorithm was no longer able to predict ROP requiring treatment at their institution after the implementation of higher target oxygen saturation levels, with a sensitivity of only 50%.5 The objective of this review was to evaluate WINROP's ability to identify infants at risk for severe ROP at our institution after target oxygen saturation levels were increased in 2014.
I Walked with a Zombie : Colonialismo e intertextualidad

This article is about some uses of intertextuality between cinema and literature. I Walked with a Zombie (1943) is the second of nine films produced by Val Lewton that shaped the horror genre and had a lasting influence on the language of cinema. Reframing the classic Victorian novel Jane Eyre in a Caribbean setting, the film outlines the fault-lines of the European colonial enterprise long before the advent of postcolonial studies. Jean Rhys’s partly autobiographical novel Wide Sargasso Sea (1966) rewrites Jane Eyre in a feminist and postcolonial perspective. In Manuel Puig’s novel Kiss of the Spider Woman, cinema and films, including I Walked with a Zombie , are the intertextual means to the creation of literary character and the figure of a love that has no name.
Role of Cholesterol and Phospholipids in Amylin Misfolding, Aggregation and Etiology of Islet Amyloidosis

Amyloidosis is a biological event in which proteins undergo structural transitions from soluble monomers and oligomers to insoluble fibrillar aggregates that are often toxic to cells. Exactly how amyloid proteins, such as the pancreatic hormone amylin, aggregate and kill cells is still unclear. Islet amyloid polypeptide, or amylin, is a recently discovered hormone that is stored and co-released with insulin from pancreatic islet β-cells. The pathology of type 2 diabetes mellitus (T2DM) is characterized by an excessive extracellular and intracellular accumulation of toxic amylin species, soluble oligomers and insoluble fibrils, in islets, eventually leading to β-cell loss. Obesity and elevated serum cholesterol levels are additional risk factors implicated in the development of T2DM. Because the homeostatic balance between cholesterol synthesis and uptake is lost in diabetics, and amylin aggregation is a hallmark of T2DM, this chapter focuses on the biophysical and cell biology studies exploring molecular mechanisms by which cholesterol and phospholipids modulate secondary structure, folding and aggregation of human amylin and other amyloid proteins on membranes and in cells. Amylin turnover and toxicity in pancreatic cells and the regulatory role of cholesterol in these processes are also discussed.
Tools for generation risk management

The first part of the paper is on a comprehensive price-based unit commitment (PBUC) formulation. it is perceived that GENCOs would use PBUC to schedule their generating units on short-term, and determine optimal bids for energy and ancillary services in order to maximize their profits. PBUC is a mixed integer program, which considers the characteristics of individual units, and is solved based on the augmented Lagrangian relaxation. The input to PBUC will also include market price forecasts. The output of PBUC will identify the on/off schedules of available generating units within the scheduling horizon. The PBUC solution will be for multiple products (energy and ancillary services portfolio) and will consider bidding in multiple markets. The second part of the presentation encompasses generation asset valuation and value-at-risk (VaR) for measuring the risk of committing the generating assets. The asset valuation problem is formulated as a multi-stage problem and VaR is used as an index for measuring risk. The presumption in this study is that there are hourly markets for both electricity and fuel with fluctuating prices. A Monte Carlo simulation is used for modeling different pricing and generation scenarios and calculate VaR for minimizing the financial risk of GENCOs for supplying the generation to the market.
Erythema multiforme: Clinical characteristics and natural history in fifty patients

Erythema multiforme is a chronic mucocutaneous inflammatory disease with a variable recurrent pattern. Thirty female and twenty male patients, ranging in age from 11 to 75 years, were studied. Twelve patients had oral lesions only, nineteen had oral and lip changes, and nineteen had oral, lip, and skin involvements. Most of the patients had a noncyclical pattern of attacks which required systemic corticosteroid therapy. When the disease attacks electively were not treated, healing would vary between 2 and 24 weeks. This study confirmed the idiopathic nature and extremely variable features of erythema multiforme. Frequency, location, duration, and severity of attacks did not shed any clues as to trigger mechanisms (etiology), persons who might be predisposed to such attacks, treatment responses, or prognosis.
Genetic Resources, Chromosome Engineering, and Crop Improvement. Volume 5: Forage Crops: Edited by Ram J. Singh

2009, CRC Press, Boca Raton, FL 33487-2742, USA 323 pp, hardcover ISBN 978–1-4200–4739-4. Price US$144.95
Bladder cancer: Chemohyperthermia for bladder cancer—clinically effective?

More effective treatment strategies are desperately needed for non-muscle-invasive bladder cancer due to the high costs of therapy and surveillance, and the substantial risk of ongoing recurrence or progression to muscle-invasive disease. A recent paper reviews the state of the art regarding combination intravesical chemotherapy and hyperthermia for bladder cancer.
A Sharp PageRank Algorithm with Applications to Edge Ranking and Graph Sparsification

We give an improved algorithm for computing personalized PageRank vectors with tight error bounds which can be as small as Ω(n − p ) for any fixed positive integer p. The improved PageRank algorithm is crucial for computing a quantitative ranking of edges in a given graph. We will use the edge ranking to examine two interrelated problems – graph sparsification and graph partitioning. We can combine the graph sparsification and the partitioning algorithms using PageRank vectors to derive an improved partitioning algorithm.
Electrical and Electronic Measurements, Introduction

Electrical and electronic measurements of materials are among the most powerful techniques available for materials characterization. These measurements can reveal information that completely characterizes the electrical transport properties of the material. Furthermore, modern instrumentation makes precision measurements and computer interfacing straightforward at reasonable cost. Keywords: electrical measurements; electronic measurements; introduction
Consistency of LEP event excesses with an h→aa decay scenario and low-fine-tuning next-to-minimal supersymmetric standard models

We examine the LEP limits for the Zh{yields}Z+b's final state and find that the excess of observed events for m{sub h}{approx}100 GeV correlates well with there being an m{sub h}{approx}100 GeV Higgs boson with SM-like ZZh coupling that decays partly via h{yields}bb+{tau}{sup +}{tau}{sup -} [with B(h{yields}bb){approx}0.08] but dominantly via h{yields}aa [with B(h{yields}aa){approx}0.9], where m{sub a}<2m{sub b} so that a{yields}{tau}{sup +}{tau}{sup -} (or light quarks and gluons) decays are dominant. This type of scenario is precisely that predicted in the Next-to-Minimal Supersymmetric Model for parameter choices yielding the lowest possible fine-tuning.
Virtual cluster management with Xen

Recently, virtualization of hardware resources to run multiple instances of independent virtual machines over physical hosts has gained popularity due to an industry-wide focus on the need to reduce the cost of operation of an enterprise computing infrastructure. Xen is an open source hypervisor that provides a virtual machine abstraction layer which is very similar to the underlying physical machine. Using multiple physical hosts, each hosting multiple virtual machines over a VMM like Xen, system administrators can setup a high-availability virtual cluster to meet the ever-increasing demands of their data centers. In such an environment, the Xen hypervisor enables live migration of individual virtual machine instances from one physical node to another without significantly affecting the performance of the applications running on a target virtual machine. This paper describes a scalable Virtual Cluster Manager that provides such application agnostic cluster management capabilities to the system administrators maintaining virtual clusters over Xen powered virtual nodes.
The lambda Phi^4 Miracle: lattice data and the zero-point potential

Recent lattice data for the effective potential of lambda Phi^4 theory fits the massless one-loop formula with amazing precision. Any corrections are at least 100 times smaller than is reasonable, perturbatively. This is strong evidence for the "exactness conjecture" of Consoli and Stevenson.
Hematopoietic stem cell transplantation

This chapter deals with different aspects related to Hematopoietic stem cell transplantation (HSCT). It has become an accepted therapeutic modality for a wide variety of diseases and is increasingly utilized for the treatment of malignant and nonmalignant disorders. Preparation for HSCT involves delivery of high dose chemotherapy with or without radiation to ablate normal hematopoiesis and provide sufficient immunosuppression to allow donor cell engraftment. Hematopoietic growth factor support offers the potential to maximize the dose response effort of high dose therapy. The most common form of stem cell transplantation to treat leukemia is allergenic, using a human leukocyte antigen. Solid tumors are treated with high-dose chemotherapy followed by autologous bone marrow transplantation or peripheral blood stem cell transplantation with concomitant use of hematopoietic growth factors. This chapter also reviews the sources and indications for allogenic and autologous HSCT, as well as their advantages and disadvantages. Post stem cell transplantation, patients do not require any chemotherapy with the exception of certain patients with lymphoma.
Challenges in SN38 drug delivery: current success and future directions

Introduction: Clinical use of SN38 is limited by its poor aqueous solubility and hydrolysis of the lactone ring at pH > 6 to inactive carboxylate form. A variety of drug delivery systems have been developed to improve the solubility and stability of SN38, and reduce its toxicity. A few noteworthy formulations with some success in initial phases of clinical trials are reported.Areas covered: This work aims to provide a comprehensive review on the various techniques and strategies employed (physical, chemical and biological methods) to improve physicochemical properties and to deliver the drug efficiently to the cancer cells. Physical methods such as nanoparticle encapsulation, cyclodextrin complexation; chemical methods such as prodrugs, polymer-, albumin- and immunoconjugates; and enzyme activated prodrug therapy are discussed.Expert opinion: The challenges in SN38 drug delivery may be overcome by two ways: ensuring multiple layers of protection against degradation and slow but sustained release of therap...