cssi/SciSciGPT-SciSciNet huggingface dataset:
The Process of Becoming an Embedded Curriculum Librarian in Multiple Health Sciences Programs

Higher education is moving to offer more fully online programs, and the health science fields are no different. These programs are either hybrid or completely online. It is up to the health sciences librarian to adapt services offered by the academic library to these types of courses. This column discusses the multiple ways a librarian can be an embedded librarian in a course using a learning management system (LMS). The process of creating a customized embedded librarian program, results, and lessons learned from the different embedded librarian roles are also discussed.
Adaptive calibration of wideband digital beam formers with injection calibration

This paper presents a closed-loop internal adaptive calibration method for wideband digital beam formers in phased array applications. The channels are time aligned and calibrated before beam forming using an internal network for illumination and correction of the elemental electronic channels. This approach lowers the cost of wideband phased arrays by eliminating manual factory tuning. The internal calibration network enables calibration during operation without the implicit electromagnetic compatibility (EMC) concerns of a cooperative radiating source. The approach facilitates correcting for age related changes from the initial factory calibration, and for the inherent factory calibration residual errors. Measured data from an existing 22-phase center elemental digital beam former array was used to evaluate the method. The channel response was extracted and bit error rate (BER) was evaluated using a simulation test bench. The results show two orders of magnitude improvement in BER over a narrow band method based on singular value decomposition.
Efficient and Accurate Methods for the Geometry Optimization of Water Clusters: Application of Analytic Gradients for the Two-Body:Many-Body QM:QM Fragmentation Method to (H2O)n, n = 3–10

The structures of more than 70 low-lying water clusters ranging in size from (H2O)3 to (H2O)10 have been fully optimized with several different quantum mechanical electronic structure methods, including second-order Moller-Plesset perturbation theory (MP2) in conjunction with correlation consistent triple-ζ basis sets (aug-cc-pVTZ for O and cc-pVTZ for H, abbreviated haTZ). Optimized structures obtained with less demanding computational procedures were compared to the MP2/haTZ ones using both MP2/haTZ single point energies and the root-mean-square (RMS) deviations of unweighted Cartesian coordinates. Based on these criteria, B3LYP/6-31+G(d,2p) substantially outperforms both HF/haTZ and MP2/6-31G*. B3LYP/6-31+G(d,2p) structures never deviate from the MP2/haTZ geometries by more than 0.44 kcal mol(-1) on the MP2/haTZ potential energy surface, whereas the errors associated with the HF/haTZ and MP2/6-31G* structures grow as large as 12.20 and 2.98 kcal mol(-1), respectively. The most accurate results, however, were obtained with the two-body:many-body QM:QM fragmentation method for weakly bound clusters, in which all one- and two-body interactions are calculated at the high-level, while a low-level calculation is performed on the entire cluster to capture the cooperative effects (nonadditivity). With the haTZ basis set, the MP2:HF two-body:many-body fragmentation method generates structures that deviate from the MP2/haTZ ones by 0.01 kcal mol(-1) on average and not by more than 0.03 kcal mol(-1).
A State Program of Insect Control

A few well planned projects of long time duration constitute the control program. Existing related agencies are utilized to aid in carrying them to the public. Examples are given of how insect control information is disseminated.
The Use of a Route and Survey Composite Display for Navigational Training in Virtual Environments

The present study examined if spatial knowledge gained from a virtual environment (VE) is affected by the spatial ability of the participant and whether information can be more efficiently acquired and applied to a physical space when participants are given a display featuring both an overhead map and first-person visual cues. Seventy-four participants were randomly assigned to one of three VE conditions: first-person view, overhead map, or first-person view with an integrated map. Participants learned the locations of 7 targets in a desktop-based computer simulation of a building. Spatial knowledge for these targets was assessed in the physical building. Results indicated that spatial orientation ability facilitated performance by the group with only the map view. Spatial orientation ability did not affect the other two groups.
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases

CRISPR-Cas9 RNA-guided nucleases are a transformative technology for biology, genetics and medicine owing to the simplicity with which they can be programmed to cleave specific DNA target sites in living cells and organisms. However, to translate these powerful molecular tools into safe, effective clinical applications, it is of crucial importance to carefully define and improve their genome-wide specificities. Here, we outline our state-of-the-art understanding of target DNA recognition and cleavage by CRISPR-Cas9 nucleases, methods to determine and improve their specificities, and key considerations for how to evaluate and reduce off-target effects for research and therapeutic applications.
Effect and Mechanism of Anions and Humic Acid in Aqueous Solution on Degradation of 2,4-DCP by UV/H_2O_2 Combination Process

The effect of UV/H2O2 process as well as anions and humic acid in aqueous solution on degradation of 2,4-DCP was studied.Results showed that UV/H2O2 process could remove 2,4-DCP effectively,with the process of photodegradation following the first order reaction kinetics model.Under the condition of H2O2 concentration of 8mg/L and irradiation of 30W low pressure mercury vapor discharge lamp,the photodegradation rate constant of 2,4-DCP in distilled water and tap water was 0.0232min-1 and 0.0162min-1 respectively.NO3-,Cl-and HCO3-has inhibitory action on photodegradation of 2,4-DCP.When anion concentration was 0.5mmol/L,10 mmol/L and 20 mmol/L,the inhibitory action order was HCO3-,NO3-and Cl-.The higher anions concentration was,the stronger inhibitory action.It was anions synthetic effect that caused photodegradation rate constant of 2,4-DCP in tap water lower than distilled water.Low humic acid concentration accelerated 2,4-DCP photodegradation rate while high humic acid concentration restrained photodegradation.
Screening for skin cancer.

Case study: A 65-year-old white man is in your office for a routine evaluation of his blood pressure. He complains of decreased urinary stream and nocturia. You notice that he has not had a rectal examination in the past two years, and you prepare to do this examination. When he has disrobed, you notice an irregularly shaped, dark skin lesion on the upper right posterior leg.
Development of a flotation model incorporating liberation characteristics

Abstract A liberation/flotation model has been developed to evaluate flotation performance, in which the grade distribution of composite particles is incorporated explicitly. The grade distribution of particles at a given size fraction was calculated using a predictive liberation model developed by the authors. Flotation behaviour of these particles in narrow size fractions were evaluated using batch flotation tests. The recovery of particles in narrow size/grade classes at various flotation times under a given flotation environment were obtained from SEM images of mounted specimens of feed, concentrate and tailings samples using image analysis techniques. By describing the size, grade and recovery data of particles in narrow size/grade classes by separate matrices, a transformation matrix technique has been developed that can predict the flotation performance of a composite sample of an ore comprising various size classes. It has been shown that the predicted results agree well with the observed results. This liberation/flotation model has wide applications in geometallurgical testing and design, where the downstream flotation performance is to be determined with limited availability of ore samples and their liberation characteristics. It also alleviates the deficiencies involved with flotation models that assumes first order behaviour.
Neighborhood characteristics, testosterone metabolism genotypes, and prostate cancer etiology.

Fifth AACR International Conference on Frontiers in Cancer Prevention Research, Nov 12-15, 2006 B194 Neighborhood characteristics such as poverty and educational attainment have been shown to influence various health outcomes, including cancer risks and outcomes. Individual characteristics including screening, genetics, lifestyle, and exposures also contribute to cancer etiology and outcomes. However, there have been few studies of multilevel influences on cancer etiology or outcomes that consider both neighborhood and individual factors simultaneously. Thus, we evaluated the joint relationship of socioeconomic status and educational attainment of residential census tract with genetic effects on prostate cancer using 1,002 Caucasian prostate cancer cases and 387 Caucasian controls. We geocoded the addresses of each participant to the census tract level using 2000 U.S. census data, and determined median cutpoints of census tract-specific values for analysis, including low per capita income (<$25,319), high poverty (<4.9%), and low high school graduation (<88.3%) . Genotypes of the androgen receptor (AR) CAG repeats (< 20 vs. ≥ 20) and SRD5A2-V89L or SRD5A2-A49T variants were studied. Genotype-neighborhood interactions were evaluated using logistic regression models, adjusted for age and participants' educational attainment. Genotype main effects on prostate cancer occurrence were in the expected directions based upon previous reports. However, genotype effects were observed primarily in men residing in the least deteriorated census tracts. We observed a significant interactions between SRD5A2-V89L for high-stage case status between high (OR=0.57, 95% CI=0.38-0.86) and low (OR=1.27. 95% CI=0.76-2.11) per capita income census tracts (interaction p-value=0.017). In addition, we observed a significant genotype-neighborhood interaction for AR-CAG genotypes among men living in areas with a higher percent of high school graduates (OR=0.55, 95%CI=0.32-0.95) compared to men residing in tracts with a lower percent of high school graduates (OR=1.23 95%CI=0.72-2.10; interaction p-value=0.040). Our findings confirm previous associations of testosterone metabolism genes with prostate cancer, and suggest that these genetic effects may be modulated by neighborhood characteristics including poverty and educational attainment. The etiological explanation for these neighborhood effects may include exposure to stress or other unhealthy lifestyle factors, for which neighborhood characteristics are a surrogate. These results therefore suggest that studies of genotype-environment interactions of cancer etiology or outcomes may expand the definition of "environment" to include both individual and neighborhood characteristics.
Mobile receive diversity technology improves 3G systems capacity

This work explores mobile receive diversity (MRD) technology for cdma2000 (3G) systems that operate in the 1900 MHz frequency band. MRD technology uses more than one antenna in mobile terminals to improve the service, capacity and coverage of the underlying systems. This paper focuses on the field testing conducted by Sprint Corporation to evaluate the MRD technology via prototype handsets and commercial base stations. Although the prototype handsets had their limitations, the testing revealed voice and data capacity gains in excess of 3 dB in the forward link (base station to mobile).
Growth and Enterotoxin Production by Staphylococcus aureus in Whey from the Manufacture of Domiati Cheese.

Staphylococcus aureus able to produce enterotoxin A was inoculated into Domiati cheese whey treated four different ways. Included were raw and pasteurized whey with 15% salt and unsalted raw and pasteurized whey. All wheys and their controls were kept at 30°C, and tested after 6, 12, 24, 48 and 72 h. There was a substantial loss in viability of S. aureus after 6 h of incubation in unsalted raw whey. Substantial loss of viability by S. aureus occurred in unsalted heat-treated whey after 24 h of incubation. S. aureus decreased in number slowly after 24 and 48 h of incubation in both salted raw and salted pasteurized whey. Thermonuclease and enterotoxin A were detected in unsalted heat-treated whey at and after 24 h when the number of S. aureus was 1.6 × 108/ml. Thermonuclease could not be detected after 6 h of incubation of unsalted or salted raw whey and after 48 h of incubation of salted whey.
A Comparison of the Impacts of PQ4R and Mind Mapping

Two learning methods which continue to receive interest from educational professionals is mind mapping and the preview, question, read, reflect, recite, and review (PQ4R) method. This study examines which method is more effective at raising academic performance in a 10th grade social studies class over one unit of study
Prospective Longitudinal Study of Predictors of Postpartum-Onset Depression in Women With a History of Major Depressive Disorder

OBJECTIVE Risk factors for postpartum depression in euthymic pregnant women with histories of major depressive disorder (MDD) were evaluated. METHODS From April 2003 to March 2009, 343 pregnant women with a history of Structured Clinical Interview for DSM-IV (SCID)-diagnosed major depressive disorder were prospectively assessed from the third trimester into the postpartum period using the SCID mood module and 17-item Hamilton Depression Rating Scale (HDRS). Data from 300 subjects who completed at least 2 mood module assessments (1 within 60 days before and the other within 60 days after delivery) were analyzed for predictive associations between variables assessed in the third trimester and the development of a postpartum depression. RESULTS The majority of women were euthymic in pregnancy by SCID criteria. Women with third trimester SCID-diagnosed depression (n = 45) versus euthymia (n = 255) had a significantly higher risk for having depression after delivery (24% vs 11%, P = .013). For pregnant euthymic women, third trimester total HDRS scores significantly predicted postpartum depression (P < .0001); specifically, scores on 3 HDRS items alone-work activities, early insomnia, and suicidality-significantly predicted postpartum depression. Antidepressant use in the third trimester in euthymic women did not confer protection against the onset of postpartum depression. CONCLUSIONS Among women with a history of MDD who are euthymic in the third trimester, 3 HDRS items-work activities, early insomnia, and suicidality-may be useful as screening items for clinicians working with pregnant women with histories of MDD to identify a group at risk for developing postpartum depression. Additionally, in euthymic women with a history of MDD, antidepressant use in the third trimester may not reduce the risk of developing postpartum depression.
Radiotherapy for stage I and II testicular seminomas: Secondary malignancies and survival.

Abstract Introduction Testicular seminoma affects relatively young men with excellent survival outcomes. There has been increasing concern that radiotherapy (RT) leads to secondary malignant neoplasms (SMNs) and subsequent mortality. We evaluated the effect of RT on incidence of SMNs and quantified cancer-related mortality and other causes of death for patients with stage I and II testicular seminoma. Material and methods A national sample of men (1988–2013) diagnosed with stage IA/IB/IS/IIA/IIB/IIC testicular seminomas from Surveillance, Epidemiology, and End Results were evaluated. Use of RT over time and survival curves (5/10/15-year) was stratified by stage. Log-binomial regression determined relative risk of developing SMNs. Incidence rate ratios (IRR) and age-adjusted Cox proportional hazards models compared overall, cancer-specific survival (CSS), and other cancer-specific survival. Competing-risks regression generated cumulative incidence functions. Prevalence ratios explored excess deaths owing to specific causes. Results A total of 16,463 men were included with 9,126 (55.4%) undergoing RT with markedly decreased use for stage I seminoma in recent years ( Conclusions RT offers excellent CSS for men with stage I/II seminoma and an increased risk of SMN later in life. Future studies should better evaluate risk-stratification for stage IB patients.
20 – AL–AUGITE AND CR–DIOPSIDE ULTRAMAFIC XENOLITHS IN BASALTIC ROCKS FROM WESTERN UNITED STATES*

Ultramafic xenoliths in basalts from the western United States are divided into Al-augite and Cr-diopside groups. The Al-augite group is characterized by Al, Ti-rich augites, comparatively Fe-rich olivine and orthopyroxene, and Al-rich spinel, the Cr-diopside group by Cr-rich clinopyroxene and spinel and by Mg-rich olivine and pyroxenes. Both groups have a wide range of subtypes, but the Al-augite group is dominated by augite-rich varieties, and the Cr-diopside group by olivine-rich lherzolites.
Eigenvalue Approximations for Numerical Observability Problems

Effort is being made to develop numerical procedures for approximating initial or boundary data for parabolic problems that arise, for example, in inverse heat conduction problems and observability of distributed parametic systems in mathematical control theory ([2],[3]).
Argument and Ideology: A Conceptually Adrift Introduction

(1987). Argument and Ideology: A Conceptually Adrift Introduction. The Journal of the American Forensic Association: Vol. 24, No. 1, pp. 1-3.
Coregulatory Proteins in Nuclear Hormone Receptor Action

Publisher Summary Steroid hormones exert their major biological effects on differentiation, growth, homeostasis, and behavior by binding to nuclear receptors, which, in turn, regulate patterns of gene expression in appropriate target cells. Members of the steroid receptor superfamily include not only receptors for steroid hormones but also receptors for various other lipophilic ligands such as thyroid hormone, retinoids, and vitamin D 3 . Nuclear receptors are phosphoproteins, and most of the phosphorylation sites, which have been identified, are serine-threonine residues located in the amino terminus. Nuclear accessory proteins that facilitate the sequence-specific DNA-binding activity of the steroid class of receptors are described in this chapter. These proteins do not heterodimerize with steroid receptors per se, they form a ternary complex with receptor homodimers on target DNA. The solution structure of the high-mobility group box has revealed a novel DNA-binding motif consisting of three helices folded into an L shape. It is found that helices 1 and 2 form the short arm of the L, which is held at an approximately 80° angle from helix 3 and an extended amino terminal segment that together form the long arm.
[14C]iodoantipyrine and microsphere blood flow estimates in cat brain

A comparison of local cerebral blood flow estimates with the microsphere and the 4-[N-methyl-14C]iodoantipyrine ([14C]IAP) techniques has been performed in cats. Good correlation of [14C]IAP with microsphere flow estimates in the gray matter was found. In the white matter, however, [14C]IAP flow estimates were consistently lower than microsphere flow estimates. Error analysis of both techniques and comparison with previous studies suggest that peculiarities of white matter arterial vasculature with preferential microsphere accumulation may lead to this discrepancy. Microspheres did not interfere with flow as shown by the normal appearance of subsequent [14C]IAP autoradiograms. The number of microspheres seen on autoradiograms was used for an estimate of microvessels blocked by spheres and found to be negligible. The study also demonstrates that [14C]IAP is not diffusion limited up to the observed flow values of 2 ml.g-1.min-1. Both techniques might be used together for a combination of their respective advantages, which are temporal and spatial resolution for microsphere and [14C]IAP, respectively.
Shannon impossibility, revisited

In this note we revisit the famous result of Shannon [Sha49] stating that any encryption scheme with perfect security against computationally unbounded attackers must have a secret key as long as the message. This result motivated the introduction of modern encryption schemes, which are secure only against a computationally bounded attacker, and allow some small (negligible) advantage to such an attacker. It is a well known folklore that both such relaxations -- limiting the power of the attacker and allowing for some small advantage -- are necessary to overcome Shannon's result. To our surprise, we could not find a clean and well documented proof of this folklore belief. (In fact, two proofs are required, each showing that only one of the two relaxations above is not sufficient.) Most proofs we saw either made some limiting assumptions (e.g., encryption is deterministic), or proved a much more complicated statement (e.g., beating Shannon's bound implies the existence of one-way functions [IL89].)
Recurrent Neural Network for (Un-)Supervised Learning of Monocular Video Visual Odometry and Depth

Deep learning-based, single-view depth estimation methods have recently shown highly promising results. However, such methods ignore one of the most important features for determining depth in the human vision system, which is motion. We propose a learning-based, multi-view dense depth map and odometry estimation method that uses Recurrent Neural Networks (RNN) and trains utilizing multi-view image reprojection and forward-backward flow-consistency losses. Our model can be trained in a supervised or even unsupervised mode. It is designed for depth and visual odometry estimation from video where the input frames are temporally correlated. However, it also generalizes to single-view depth estimation. Our method produces superior results to the state-of-the-art approaches for single-view and multi-view learning-based depth estimation on the KITTI driving dataset.
The Preventive Role of Angiotensin Converting Enzyme Inhibitors/Angiotensin-II Receptor Blockers and β-Adrenergic Blockers in Anthracycline- and Trastuzumab-Induced Cardiotoxicity

Anthracycline (doxorubicin) and trastuzumab treatments for cancer patients have been known to cause cardiotoxicity. The current recommendations for prevention of cardiac events from cancer chemotherapies are largely based on opinion. The American Society of Clinical Oncology recommends active screening and prevention of modifiable cardiovascular risk factors. The risk factors are defined as tobacco use, high blood pressure, high cholesterol, alcohol use, obesity, and physical inactivity. Beta-adrenergic blockers and angiotensin converting enzyme (ACE) inhibitors/angiotensin receptor blockers (ARBs) have been the mainstay of treatment for heart failure patients with reduced left ventricular ejection fraction for many years. This review analyzed the use of beta-adrenergic blockers and ACE inhibitors/ARBs as protection against cardiomyopathy caused by anthracyclines and trastuzumab. Although many more studies are warranted, it was concluded that the addition of a beta-blocker early in the treatment of cancer patients who are undergoing anthracycline or trastuzumab treatment can have beneficial effects in preserving left ventricular ejection fraction and preventing chemotherapy-induced cardiotoxicity. The effects are more apparent in the short term. More studies of the long-term effects are warranted, as are the additive effects of using a beta-blocker and ACE inhibitor/ARB together to prevent chemotherapy-induced cardiotoxicity.
Rapid in-field failures following adjuvant radiation for buccal squamous cell carcinoma.

Objectives/hypothesis Squamous cell carcinoma originating in the buccal mucosa and retromolar trigone (RMT) have historically poor outcomes. Difficulties in discriminating tumor origin often result in these subsites being combined in surgical and pathological reports. We aimed to determine if making this anatomical distinction has implications for treatment design and clinical outcomes. Study design Retrospective case series. Methods We identified 27 tumors from either the buccal mucosa patients or RMT patients who underwent surgery followed by radiation. For patients who developed a local failure, we fused the pretreatment imaging, simulation computed tomography, and follow-up imaging to determine the location of failures relative to the radiation field. We calculated the 2-year locoregional control and 2-year disease-free survival. Results The median time from surgery to radiation was 50 days (range, 32-133 days). The 2-year locoregional control for buccal mucosa versus RMT, respectively, were 35.9% versus 68.4% (P = .252). The 2-year disease-free survival rates were 32.7% versus 68.4%, respectively (P = .196). The median times to failure were 12.00 months (range, 4.9-115.0 months) versus 18.5 months (range, 4.5-61.0 months), respectively. All buccal mucosa failures occurred within the high-dose planning target volume, with a median dose of 60 Gy within the failure region. Following locoregional failure, 10 of the 12 patients have died, with a median time from local failure to death of 3.6 months (range, 1-17.6 months). Conclusions Squamous cell carcinomas of the buccal mucosa appear to have a poor prognosis characterized by rapid in-field failure. Therefore, differentiating tumor origin may be important for prognostication and treatment. Level of evidence 3 Laryngoscope, 130:413-417, 2020.
Parental Factors as Predictors of Dating Violence Among Latinx Adolescent Mothers.

The purpose of our study was to examine how parental stress and coparenting relationship quality were related to dating violence perpetration and victimization among 114 Latinx adolescent mothers. ...
Method for Deriving Telescope Specifications for Earth-Detecting Coronagraphs and Its Use in Prioritizing Technology Development Investments

Different potential exoplanet mission concepts require different enabling and enhancing technologies. Decisions regarding prioritizing the development of these technologies can be made using a Science-Driven Systems-Engineering framework. The white paper makes the following specific recommendations. (1) Any potential telescope/coronagraph combination should develop a wavefront stability error budget using the method described in this white paper. That error budget will inform discussions about what technology development will be needed to enable the mission. (2) Enhancing and enabling technologies requiring investment include: low noise reaction wheels or control moment gyros; micro-thruster technology; active vibration isolation; materials and design practice for making lightweight stiff structures and optical components; 200-hertz wavefront sensing and control; 500-hertz sub-picometer-precision edge sensor and position actuators; non-destructive process to quantify CTE (Coefficient of Thermal Expansion) homogeneity of 4-meter class mirrors to an uncertainty of plus or minus 1 parts per billion per degree Kelvin over a 100 by 100 sampling; laser gauge positional metrology system; and predictive active thermal control.
Inherited Platelet Defects and Mutations in Hematopoietic Transcription Factor RUNX1

Increasing evidence implicates mutations in hematopoietic transcription factors (TFs) as an important cause for inherited defects in platelet production, morphology, and function. TFs are proteins that bind to specific DNA sequences and regulate gene expression, with each TF regulating numerous genes. They act in a combinatorial manner to bind sequence-specific DNA within promoter regions to regulate lineage-specific gene expression, either as activators or repressors. The hematopoietic TFs associated with impaired platelet function and number include the runt related transcription factor 1 (RUNX1), Fli-1 proto-oncogene, ETS transcription factor (FLI1), GATA-binding protein 1 (GATA1), growth factor independent 1B transcriptional repressor (GFI1B), ETS variant 6 (ETV6), ecotropic viral integration site 1 (EVI1), and homeobox A11 (HOXA11). Mutations involving these TFs affect diverse aspects of megakaryocyte and platelet biology, leading to thrombocytopenia, platelet dysfunction, and often both. Some are associated with predisposition to hematologic malignancies. This review focuses on the inherited platelet abnormalities associated with mutations in RUNX1.
Approximate Mixed-Integer Programming Solution with Machine Learning Technique and Linear Programming Relaxation

Security constrained unit commitment (SCUC) is solved in the day-ahead electricity market to determine electricity generation schedule for the following date. The associated mixed integer programming (MIP) problem is known computationally hard. Heuristics like rounding can be computationally efficient for solving large MIP problems however often produces lower quality solutions due to discrepancy between MIP solution and linear programming relaxation (LPR) solution, i.e., variables taking different discrete values between MIP and LPR solutions. In this work, we applied the machine learning-based algorithms—Classification and Regression Tree (CART) model and random forest (RF) model—to obtain an LPR-based approximation that close to an MIP solution without actually solving the MIP problem. By computing feature importance derived from the CART and RF models, we assessed the link between coefficients in the MIP model, the LPR solution, and the optimal solution of the MIP problem. We applied the CART and RF approaches to solve SCUC problems using day-ahead energy market cases from Midcontinent Independent System Operator. The results show that our method is computationally efficient and could achieve an approximation sufficiently close to the SCUC solution with <0.15% error and ~78% reduction in the discrepancies between LPR and MIP solutions.
Sensitivity of Energy-Efficient Driving to Motor Efficiency for EVs

This paper is an extension of our previous study on optimizing energy-efficient speed profiles of electric vehicles. This paper investigates the influence of motor efficiency on performance, including the energy consumption and control modes through parametric studies, for a light weight military ground vehicle. A comprehensive comparison is conducted between the global optimal solutions obtained from DP with nonlinear motor efficiency, and the suboptimal solutions derived from various constant efficiencies. The global optimal solutions lead to about 2-3% lower energy consumption than the suboptimal solutions for the considered driving scenarios. It is observed that the energy consumption and control modes of the suboptimal solutions are hardly affected by the motor efficiency. For a flat road, the control modes of the global optimal solutions, characterized as Pulse and Glide, are considerably different from those of the suboptimal solutions. However, no significant difference is observed in control modes for a hilly terrain.
Novel Backoff Mechanism for Mitigation of Congestion in DSRC Broadcast.

Due to the recent re-allocation of the 5.9 GHz band by the US Federal Communications Commission (FCC), it will be inevitable that dedicated short-range communications (DSRC) and cellular vehicle-to-everything (C-V2X), two representative technologies for V2X, have to address coexistence. Especially, the distributed nature of DSRC makes it not trivial to control congestions due to an asynchronous structure, which makes it inefficient to disseminate a controlling signal. To this end, we propose a method to "lighten" a distributed V2X networking. Technically, it is to allocate the backoff counter according to the level of an accident risk to which a vehicle is temporarily exposed. We provide an analysis framework based on a spatiotemporal analysis. The numerical results show the improvement in the successful delivery of basic safety messages (BSMs).
My Dull Deaf Ears: Four Millennia of Acquired Hearing Loss

Millennia have passed since the first medical recognition of acquired hearing loss. Yet, our ears are still afflicted by the same tribulations today, most prominently presbycusis, noise trauma, and drug-induced hearing loss. Despite an increasingly detailed insight into the pathophysiology and underlying molecular pathology, our ability to ameliorate the deafening consequences of environmental insults remains limited. This chapter takes readers from a concise assessment of the current state of knowledge of the death and dying of our auditory sensory cells to questions of otoprotection and to promising targets of future—and perhaps futuristic—scientific exploration. The key to our ears succumbing to outside pressure might not be the fault of an inherited individual sensitivity or an inability of hair cells to muster a valiant defense. Rather than genetics it might be lifelong changes to epigenetics that render us vulnerable; supporting cells might abandon their allegiance under stress and support death in their surroundings instead; and subtle trickeries of 100 trillion gut bacteria might wreak havoc with a few thousand hair cells.
Techniques and Forces and the Communicative Constitution of Organization: A Deleuzian Approach to Organizational (In)Stability and Power:

This article introduces five principles of Deleuzian ontology and the conceptual framework of techniques and forces into emerging CCO scholarship addressing (dis)organization and power. By introduc...
IR-improved DGLAP parton shower effects for associated production of a W boson and jets in pp collisions at s = 8 and 13 TeV

In a previous paper, hereafter referred to as I, we have analyzed the 7 TeV LHC data on W + jets events from the standpoint of IR-improved DGLAP parton shower effects, using the IR-improved Herwiri...
Drinking water contamination from the thermal degradation of plastics: implications for wildfire and structure fire response

This study was conducted to determine if the thermal degradation of various plastic drinking water pipes (i.e., PEX, HDPE, PP, PVC, and CPVC) may be a source of drinking water contamination. Widespread volatile organic compound (VOC) contamination was found in water distribution systems following three wildfires in California. A potential source of this contamination was thought to be due to the degradation of plastic components in drinking water distribution systems. Eleven plastic drinking water pipes, across eight brands, were exposed to elevated temperatures (200 °C to 400 °C), and subsequently submerged in water or in n-hexane to observe the extent of VOC leaching. Results indicated that thermally damaged drinking water pipes can be sources of VOC leaching, with ten of the eleven materials leaching benzene, a carcinogen, into water. As exposure temperature increased, an increase in VOC leaching was observed in the polyethylene materials. Conversely, in the vinyl materials the significant mass loss associated with high exposure temperature was inversely proportional to the amount of BTEX leaching that was observed. Additional tentatively identified compounds (TICs), consisting primarily of aliphatic hydrocarbons, saturated ketones, or aromatic compounds, were found in the water (22 TICs) and n-hexane (134 TICs) leachate of burned plastics. This study has significant implications for both wildfire and structure fire recovery as plastic materials are increasingly being used in buried and building plumbing, and visual inspection is not a sufficient indicator of contamination risk.
Drivers of Dissolved Organic Carbon Mobilization From Forested Headwater Catchments: A Multi Scaled Approach

Understanding and predicting catchment responses to a regional disturbance is difficult because catchments are spatially heterogeneous systems that exhibit unique moderating characteristics. Changes in precipitation composition in the Northeastern U.S. is one prominent example, where reduction in wet and dry deposition is hypothesized to have caused increased dissolved organic carbon (DOC) export from many northern hemisphere forested catchments; however, findings from different locations contradict each other. Using shifts in acid deposition as a test case, we illustrate an iterative “process and pattern” approach to investigate the role of catchment characteristics in modulating the steam DOC response. We use a novel dataset that integrates regional and catchment-scale atmospheric deposition data, catchment characteristics and co-located stream Q and stream chemistry data. We use these data to investigate opportunities and limitations of a pattern-to-process approach where we explore regional patterns of reduced acid deposition, catchment characteristics and stream DOC response and specific soil processes at select locations. For pattern investigation, we quantify long-term trends of flow-adjusted DOC concentrations in stream water, along with wet deposition trends in sulfate, for USGS headwater catchments using Seasonal Kendall tests and then compare trend results to catchment attributes. Our investigation of climatic, topographic, and hydrologic catchment attributes vs. directionality of DOC trends suggests soil depth and catchment connectivity as possible modulating factors for DOC concentrations. This informed our process-to-pattern investigation, in which we experimentally simulated increased and decreased acid deposition on soil cores from catchments of contrasting long-term DOC response [Sleepers River Research Watershed (SRRW) for long-term increases in DOC and the Susquehanna Shale Hills Critical Zone Observatory (SSHCZO) for long-term decreases in DOC]. SRRW soils generally released more DOC than SSHCZO soils and losses into recovery solutions were higher. Scanning electron microscope imaging indicates a significant DOC contribution from destabilizing soil aggregates mostly from hydrologically disconnected landscape positions. Results from this work illustrate the value of an iterative process and pattern approach to understand catchment-scale response to regional disturbance and suggest opportunities for further investigations.
Slide over: advances in slide-free optical microscopy as drivers of diagnostic pathology

Abstract Conventional clinical histopathology analysis is based on bright-field microscopy of thinly sliced tissue specimens. Although bright-field microscopy is a simple and robust method for examining microscope slides, preparing the slides needed is a lengthy and labor-intensive process. Slide-free histopathology technologies address this problem by directly imaging intact, minimally processed tissue samples using advanced optical imaging systems, bypassing the extended workflow now required for preparation of tissue sections. This manuscript explains the technical basis of slide-free microscopy, reviews common slide-free optical microscopy techniques, and discusses the opportunities and challenges involved in clinical implementation.
Oblique and Spiral Phalangeal Shaft Fractures

When possible, closed reduction and percutaneous Kirschner wire fixation are preferred for displaced spiral and oblique phalangeal shaft fractures. The functional derangement that results from such fractures is so great, however, that when closed reduction cannot be either achieved or maintained satisfactorily, open reduction is indicated. The potential for mischief of this fracture configuration is considerable. For example, soft tissue interposition often may prevent reduction. The distal spike of the proximal fragment may impale the collateralligaments of the proximal interphalangeal joint or may block flexion of the middle phalanx, and the proximal spike of the distal fragment may easily become entrapped in the flexor tendons. Most important, the tendency of the fragments to rotate and override guarantees digital crossing or scissoring and a contracture of the volar plate with flexion deformity.
Clinical and FDG PET/CT scan presentation of splenic marginal zone lymphoma

1287 Learning Objectives To describe the pathogenesis and manifestations of splenic marginal zone lymphoma (SMZL) and findings on FDG PET scan. SMZL comprises less than 5% of all non-Hodgkin’s lymphoma (NHL) and about 1% of all B-cell lymphomas. It occurs at an average age of 65; uncommon before 50. Approximately 80% of patients have abnormal karyotype. SMZL is likely arising from a post germinal center, memory B cell of splenic type. The pathogenesis of disease is unclear. It is associated with viral infections, such as hepatitis C and Kaposi’s sarcoma-associated herpes virus. The typical manifestations are splenomegaly, lymphocytosis, and cytopenia (because of hypersplenism). Compared to other NHLs, lymph node and extralymphatic organs involvement are uncommon in SMZL. Peripheral blood, focal bone marrow and liver involvement are common. The diagnosis is made based on assessment of lymphocyte morphology, immunophenotype, cytogenetic analysis, bone marrow biopsy, and spleen histology (if available). Most of the cases are in stage IV at presentation. The malignant cells replace white pulp germinal centers of the spleen, merging with an outer marginal zone of larger cells with pale cytoplasm. The red pulp is infiltrated with both small and large cells, often with villous lymphocytes circulating in the peripheral blood. The course is usually very indolent, with a median overall survival of 10 years or more. No PET imaging of SMZL has been reported in literature.
A Possible Future: Deregulation

The spot price based energy marketplace is designed to operate in a regulated environment (regulated private company, or government owned). However, its implementation opens a door to deregulation of some or all generation. This door is already being opened slowly in the United States at both the federal and state level through regulations concerning cogeneration, small power production and wheeling. The purpose of this chapter is to look behind that slowly opening door and try to see what might be there.
The "Battlefield": Life Histories of Two Higher Education Staff Members of Color.

Deploying Russian philosopher M. M. Bakhtin’s notions of utterances or communicative interactions, we explore the life histories of two administrators at State University, a predominantly White institution of higher education in the Midwestern United States. In particular, we explore how working with White students, peers, and supervisors demands that staff members of color find means of answering overt and implied criticisms of their daily work. We name and analyze metaphors each participant uses to define ways she negotiates a campus culture that privileges some and interprets others as oppositional when they call into question long held institutional priorities and practices.
Correlation of retinal cytoarchitecture and ultrastructure in Golgi preparations.

A simple procedure is described for obtaining both cytoarchitectural and ultrastructural information about nervous tissue. Freshly excised fish retinas were impregnated by a modification of Cajal's rapid Golgi procedure, embedded in Epon, sectioned at 80 μ, and scanned by light microscopy. Isolated well-impregnated cells were selected for further study and remounted for ultrathin sectioning. The appearance of 80-μ, 1-μ, and ultrathin sections was correlated. The material responsible for Golgi impregnation is a water-soluble, electron-dense precipitate which usually fills the cytoplasmic ground substance but does not penetrate the plasma membrane or membrane-bound organelles. Preservation of ultrastructure of spared organelles permits identification of cells. Since the precipitate does not encrust the outer surface but is contained within the plasma membrane, it does not obscure fine-structural relationships between cells. The method has demonstrated the complex relations of horizontal and bipolar cell processes to the receptor synaptic terminals. While less comprehensive than three-dimensional reconstruction from serial ultrathin sections, this method is much simpler, and is useful for surveying larger amounts of tissue. It may be particularly advantageous for investigating ultrastructural relationships of cell processes which are so long as to prohibit such reconstruction.
On the Generalized Rogers-Ramanujan Continued Fraction

On page 26 in his lost notebook, Ramanujan states an asymptotic formula for the generalized Rogers-Ramanujan continued fraction. This formula is proved and made slightly more precise. A second primary goal is to prove another continued fraction representation for the Rogers-Ramanujan continued fraction conjectured by R. Blecksmith and J. Brillhart. Two further entries in the lost notebook are examined. One of them is an identity bearing a superficial resemblance to the generating function for the generalized Rogers-Ramanujan continued fraction. Thus, our third main goal is to establish, with the help of an idea of E Franklin, a partition bijection to prove this identity.
Abstract T MP8: Faster Angiographic Reperfusion is Associated with Improved Outcomes Across the Full Rankin Distribution: An Ordinal Analysis of the IMS III Trial

INTRODUCTION: In the NIH-funded IMS III trial, faster angiographic reperfusion led to a greater likelihood of good clinical outcome based on the dichotomized modified Rankin Score (mRS) score of 0-2 (minimal or no disability) vs. 3-6. From 240 to 390 minutes, among 1000 patients, every 15 minute acceleration in reperfusion was associated with 32 more patients with mRS 0-2. We hypothesized that faster reperfusion would lead to better clinical outcomes across the full mRS distribution (0, 1, 2, 3, 4, 5-6). METHODS: IMS III randomized subjects to IV/endovascular vs IV tPA alone. We analyzed the endovascular cohort with M1, M2 and ICAT occlusions reperfused (TICI 2-3) during the procedure (up to 7 hours). Time to reperfusion was defined as time from stroke onset to procedure termination. The ordinal 90-day mRS as a function of time to reperfusion was assessed using a proportional odds model with adjustment for pre-morbid mRS>0, ASPECTS 0-4, and NIHSS strata (10-19 vs ≥20). “Typical patient” covariate values were used to obtain mRS distributions at prespecified time points. An algorithmic joint table analysis was applied to generate number-needed-to-treat values. RESULTS: Among 177 M1, M2, and ICAT occlusion cases with angiographic reperfusion (after excluding 2 cases with missing 90-day mRS and 3 with missing baseline ASPECTS), the common OR for improvement across all levels of the mRS was 0.78 (95% 0.66-0.91) adjusted and 0.77 (95% 0.66-0.89) unadjusted for each 30 minute increase in time. See Figure for adjusted probabilities based on the fitted model. From 240 to 390 minutes, among 1000 patients, every 15 minute acceleration in reperfusion was associated with 57 more patients with improvement of ≥ 1 mRS disability level. CONCLUSION: Faster time to reperfusion improves clinical outcomes for substantially more patients when considering the potential effects across all mRS levels, as opposed to considering a single transition between binary endpoints 0-2 vs 3-6. ![][1] [1]: /embed/graphic-1.gif
Survey concerning electronic textbooks: Assessing student behavior and environmental considerations

Purpose – A survey of students in different undergraduate majors and years asked where they bought their textbooks, the types of electronic devices they used, and their post-class use of textbook material. The research goal was to determine the groups of students likely most receptive to e-textbooks and to assess the potential environmental benefits of e-textbook adoption. The paper aims to discuss these issues. Design/methodology/approach – The student population of freshmen and juniors registered at Michigan State University were surveyed via e-mail/online in summer 2010. 477 freshmen (7.8 percent of surveyed) and 652 juniors (10.2 percent of surveyed) responded. Responses were grouped together into seven categories by student major. Findings – Surveyed students used far more print textbooks than e-textbooks. Laptops were the dominant student device and their future promise for e-textbook use is limited. The higher-than-expected rate of e-waste generation by students indicates that the environmental ben...