cssi/SciSciGPT-SciSciNet huggingface dataset:
Development and Initial Psychometric Evaluation of the Semi-Structured Emotion Regulation Interview

ABSTRACTEmotion regulation (ER) strategy use has been identified as a transdiagnostic predictor of the development, maintenance, and recovery from several forms of psychopathology. However, the ER strategy use literature relies primarily on self-report measures that have several important limitations. This article describes the development and initial psychometric evaluation of a novel clinician-administered measure of ER strategy use, the Semi-Structured Emotion Regulation Interview (SERI; Lee, Weathers, & Sloan, 2016). The SERI was developed in a construct validation framework with emphasis on a multistage content validity process. The SERI assesses frequency and efficacy (i.e., proximal change in the targeted emotion) of 9 strategies in regulation of a specified emotion type and intensity (e.g., severe anxiety) during the past 30 days. Undergraduates (N = 68) completed a battery of self-report measures and a subsequent interview. Frequency and efficacy of each strategy was assessed separately with resp...
walking where jesus walked: american christians and holy land pilgrimage

Hillary Kaell’s Walking Where Jesus Walked: American Christians and Holy Land Pilgrimage is a stunning example of lived religion scholarship at its best. Kaell’s work mines the experiences of Prote...
Experiment to Detect Proton Decay and Neutrino Oscillations (Using Cosmic Ray Neutrino Events)

A large water cherenkov detector is being constructed in a deep mine at Park City, Utah by a collaboration of Harvard, Purdue and Wisconsin physicists. The purpose of the detector is to observe proton or bound neutron decay to lifetimes of 0.7 × 1033 years. The detector is designed to be sensitive to several decay modes of the proton and to suppress the backgrounds that are naturally associated with cosmic ray muon and neutrino interactions in the walls of the mine or the overburden of the site.
A multiresolution time domain approach to RF image formation

Conventional image formation approaches rely on frequency domain Fourier methods to create images of objects. Most rely on integrating spatial resolution in the Fourier domain and do not accurately factor in the spatial aperture function to create an image because of the uniform spatial sampling necessary for the Fourier transform. We propose a multiresolution approach based on a Greens function inverse scattering method that allows us to solve for the object function directly in the time domain thereby allowing a more accurate rendering of the object in question.
THz spectroscopic investigation of selected purines and amino acids

We report the measurement and calculation of low-frequency vibrations of selected purines and amino acids by using THz time-domain spectroscopy and density functional theory. Specific features in the vibrational spectra are identified and interpreted in the 0.3-3 THz region.
PENGGUNAAN APLIKASI ZAHIR PADA PERUSAHAAN DAGANG UNTUK MEMBUAT LAPORAN KEUANGAN

Accounting information systems ranging from the balance at beginning of period, journaling, posting ledger, trial balance at end of period, the adjusting entry to preparing the reports at end of period experience recording errors, lack of accurate financial statements that were made and the delay in the search data of financial accounting. Application of Accounting Information Systems to collect data of financial transactions manually and searching for literature on financial accounting information systems to support theories relating to the processing of financial data using application Zahir. Utilization Zahir applications to process financial data in accounting information system is a data recording error solutions in accounting, financial reporting delays and the accuracy of the search data of financial accounting. Keyword : Accounting information systems, financial data, zahir
TSUNAMI INDUCED FORCES IN BRIDGES: LARGE-SCALE EXPERIMENTS AND THE ROLE OF AIR-ENTRAPMENT

In this study large scale hydraulic experiments of tsunami waves impacting a straight composite I-girder bridge were conducted in the LWF at Oregon State University. Both solitary waves and turbulent bores were tested and the experimental results revealed the existence of 4 different phases in the vertical force histories, among which is (i) a phase with a large applied moment and bridge rotation at the time of the first impact of the tsunami bore on the bridge, and (ii) a phase with a governing uplift mode of the bridge during the passage of the wave through the bridge. The first phase introduced the largest tensile forces in the offshore bearings and must be considered in order to prevent the progressive damage of bearings. In addition, the air-entrapment occurring in bridges with diaphragms was seen to (a) alter significantly the pattern of the applied pressures on the girders and below the deck in the internal chambers, (b) consistently increase the total uplift forces for all examined wave heights, and (3) cause a complex nonlinear wave-air interaction phenomenon with significant 3D effects.
Photobiomodulation therapy for androgenetic alopecia: A clinician’s guide to home-use devices cleared by the Federal Drug Administration

ABSTRACTThe market for home-use photobiomodulation devices to treat androgenetic alopecia has rapidly expanded, and the Food and Drug Administration (FDA) has recently cleared many devices for this purpose. Patients increasingly seek the advice of dermatologists regarding the safety and efficacy of these hair loss treatments. The purpose of this guide was threefold: (1) to identify all home-use photobiomodulation therapy devices with FDA-clearance for treatment of androgenetic alopecia; (2) to review device design, features and existing clinical evidence; and (3) to discuss practical considerations of photobiomodulation therapy, including patient suitability, treatment goals, safety, and device selection. A search of the FDA 510(k) Premarket Notification database was conducted using product code “OAP” to identify all home-use devices that are FDA-cleared to treat androgenetic alopecia. Thirteen commercially available devices were identified and compared. Devices varied in shape, wavelength, light sources,...
Intermetallic Compound Growth and Stress Development in Al-Cu Diffusion Couple

This paper reports experimental observations evidencing that the intermetallic compound phase interfaced with Cu in the Al-Cu diffusion couple is most likely α2-Cu3Al phase, not γ-Cu9Al4 phase as previously assumed, and that its growth to a critical thickness may result in interface failure by stress-driven fracture. These conclusions are made based on an interdiffusion study of a diffusion couple made of a thick Cu plate coated with ∼ 2-μm-thick Al thin film. The interface microstructure and lattice parameter were characterized using scanning electron microscopy and x-ray diffraction analysis. Specimens aged at temperature between 623 K (350°C) and 723 K (450°C) for various hours produced consistent results supporting the main conclusions. It is found that disordered α2-Cu3Al phase grows in a similar manner to solid-state epitaxy, probably owing to its structural similarity to the Cu lattice. The increase in the interface strain that accompanies the α2-Cu3Al phase growth ultimately leads to interface fracture proceeding from crack initiation and growth along the interface. This mechanism provides the most consistent explanation for interface failures observed in other studies.
Molecular epidemiologic survey of infectious bursal disease viruses in broiler farms raised under different vaccination programs

SUMMARY Over a span of nearly 4 yr, 246 bursal tissue samples were collected from Brazilian commercial broiler flocks (Gallus gallus) throughout the country and imprinted to sample collection cards (Flinders Technology Associates (FTA) cards). A total of 75 infectious bursal disease virus (IBDV) strains was successfully detected from the FTA card imprints and were submitted for further identification and molecular characterization. Nucleotide and predicted amino acid sequences of the IBDV surface protein VP2 were used to identify strains of the virus and place them into phylogenetic groups. The amino acids across the hypervariable region of VP2 in this study varied, but around half of all positive samples were classified as vaccine virus. The IBD viruses fell into 3 categories: variant IBDV, classic IBDV (vaccine), and very virulent (vv) IBDV. The samples were collected according to the 3 different vaccination strategies used in broilers: vectored vaccine, antigen-antibody complex vaccine, and conventional live vaccine. The genetic profile and frequency of the strains recovered from the flocks were highly dependent on the vaccination program. This information helps us gain a better understanding of the current landscape of IBD in Brazil and provides additional scientific data to support selection of the most effective vaccination strategies, products, and practices to prevent disease.
Anti-TNF therapy for treatment of extraintestinal manifestations of inflammatory bowel disease

Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) are common, affecting up to one half of IBD patients (Vavricka et al., Inflamm Bowel Dis. 21:1794–800, 2015; Bernstein et al., Am J Gastroenterol. 96:1116–22, 2001; Vavricka et al., Am J Gastroenterol. 106:110–9, 2011; Zippi et al., World J Gastroenterol. 20:17463–7, 2014; Isene et al., Scand J Gastroenterol. 50:300–5, 2015; Veloso et al., J Clin Gastroenterol. 23:29–34, 1996; Greenstein et al., Medicine 55:401–12, 1976), and are of major clinical importance because of their impact on the health and quality of life of those affected. EIM of IBD can affect nearly any organ system with a range of severity from mild to debilitating. Patients may experience one or multiple EIM simultaneously, and the presence of one EIM increases the likelihood of developing other EIM (Vavricka et al., Am J Gastroenterol. 106:110–9, 2011; Veloso et al., J Clin Gastroenterol. 23:29–34, 1996). In some cases, the EIM may be more severe than the intestinal disease itself. While some EIM such as erythema nodosum and pauciarticular arthritis typically parallel luminal disease activity, others such as uveitis and ankylosing spondylitis may be active without concomitant intestinal disease (Vavricka et al., Inflamm Bowel Dis. 21:1982–92, 2015; Levine and Burakoff, Gastroenterol Hepatol. 7:235–41, 2011). This pattern and the approach to treatment is further complicated by the fact that EIM of IBD may develop even before the onset of gastrointestinal symptoms (Vavricka et al., Inflamm Bowel Dis. 21:1982–92, 2015).
CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons

Abstract Recent data have implicated voltage-gated calcium channels in the regulation of the excitability of neurons within the mesolimbic reward system. While the attention of most research has centered on high voltage L-type calcium channel activity, the presence and role of the low voltage-gated T-type calcium channel (T-channels) has not been well explored. Hence, we investigated T-channel properties in the neurons of the ventral tegmental area (VTA) utilizing wild-type (WT) rats and mice, CaV3.1 knock-out (KO) mice, and TH-eGFP knock-in (KI) rats in acute horizontal brain slices of adolescent animals. In voltage-clamp experiments, we first assessed T-channel activity in WT rats with characteristic properties of voltage-dependent activation and inactivation, as well as characteristic crisscrossing patterns of macroscopic current kinetics. T-current kinetics were similar in WT mice and WT rats but T-currents were abolished in CaV3.1 KO mice. In ensuing current-clamp experiments, we observed the presence of hyperpolarization-induced rebound burst firing in a subset of neurons in WT rats, as well as dopaminergic and non-dopaminergic neurons in TH-eGFP KI rats. Following the application of a pan-selective T-channel blocker TTA-P2, rebound bursting was significantly inhibited in all tested cells. In a behavioral assessment, the acute locomotor increase induced by a MK-801 (Dizocilpine) injection in WT mice was abolished in CaV3.1 KO mice, suggesting a tangible role for 3.1 T-type channels in drug response. We conclude that pharmacological targeting of CaV3.1 isoform of T-channels may be a novel approach for the treatment of disorders of mesolimbic reward system.
Transplanting organs from hepatitis B positive donors: Is it safe? Is it ethical?

Liver transplant centres throughout the USA face a huge shortage of liver organs for their wait-listed patients. Various types of innovations are being considered for expansion of this donor pool. Organs that were previously deemed to be high risk are now being considered for transplantation. For the last 25 years, hepatitis B core antibody (anti-HBc+) organs have been used for liver transplantation. While the initial transplantations did reveal a high incidence of de novo hepatitis (DNH) in the recipients, the medical knowledge and experience have evolved and this risk has been markedly decreased. In this paper, medical literature evaluating the safety of such organ transplants has been reviewed. There is strong evidence to suggest that using anti-HBc+ organs with appropriate prophylaxis after transplant is a safe practice with good patient and graft survivals. In the second half of the paper, we discuss whether it is ethical to use anti-HBc+ organs. We argue that the use of such organs is in compliance with the principles of medical ethics and that society at large benefits from the use of these organs. Hence, we recommend that the use of such organs is both safe and ethical and this practice should be continued in the future.
Silver Clusters and Silver Cluster/Ammonia Complexes

The chemistry and physics of small silver clusters are reviewed. Particular attention is directed towards establishing the electronic and geometric structure of silver clusters and linking these with their chemical properties in order to understand structure/reactivity correlations at a molecular level. In this regard we focus on silver cluster/ammonia complexes as a prototype for cluster association complexes. We include new data on the optical absorption spectra of silver clusters and their cations, Agn and Ag+ n (n = 4, 7, 9, 10 and 12) and on the infrared absorption spectra of silver cluster/ammonia complexes, Agn(NH3)m (n = 4 — 18, m =1, 2).
OLINDA/EXM 2.0: The new generation dosimetry modeling code

585 Objectives The OLINDA/EXM code developed by the RAdiation Dose Assessment Resource (RADAR) Task Group of the Society of Nuclear Medicine has standardized dose calculations for diagnostic and therapeutic radiopharmaceuticals. The previous generation of anthropomorphic phantoms were based on the Oak Ridge models, which employed geometrical shapes to define the body and its organs. These models have been replaced with realistic, NURBS-type models based on the recent standardized masses defined by the ICRP in its publication 89. These and other new models have been implemented in a new version of the OLINDA/EXM code. Methods The realistic adult, pediatric, and pregnant female phantom series were used in Monte Carlo simulations to produce organ specific absorbed fractions (SAFs). These values were used with recently released decay data to produce organ dose factors (DFs), which are used by the code. Updated techniques and data for modeling the kinetics of the gastrointestinal tract, gender averaging of dose, and calculation of effective dose were also implemented in the code. The code remains in the Java environment, although its structure was reorganized. The ability to automatically combine results for multiple nuclides (e.g. from a decay series) was added. Results The code remains user-friendly and easy to use. Numerical results are not significantly different from those based on the previous generation of phantoms, although some adjustments in understanding of doses to the GI tract, as proposed by the ICRP, will be needed. The ability to calculate doses to eyes, esophagus, salivary glands, and the prostate gland, and implementation of the new effective dose weighting factors represent a significant advance. Previous phantoms and effective dose weighting factors were retained for comparisons. Conclusions The new generation of models is now available in the OLINDA/EXM code, and represents a significant improvement in standardized dose calculations
Comparison of outcomes in early-stage uterine clear cell carcinoma and serous carcinoma.

Abstract Purpose The treatment paradigm for uterine clear cell carcinoma is often linked to serous carcinoma. This study compares oncologic outcomes between women with uterine clear cell and serous carcinoma. Methods and Materials We reviewed 114 women with stage I–II uterine clear cell carcinoma (n = 17, 15%) or serous carcinoma (n = 97, 85%) who underwent hysterectomy and salpingo-oophorectomy at our institution from April 1992 to December 2011; 86 (76%) had stage IA, 14 (12%) had stage IB, and 14 (12%) had stage II disease. Median followup was 57 months. Results Patients with uterine clear cell and serous carcinoma did not differ significantly by age ≥60 years, stage, or rate of lymphovascular invasion. There was no difference in the number of patients with clear cell or serous histology who received adjuvant radiotherapy (71% vs. 84%, respectively; p = 0.31); however, significantly fewer patients with clear cell histology received adjuvant chemotherapy (35% vs. 67%, respectively; p = 0.02). At 5 years, there were no significant differences in disease-free survival (94% vs. 84%, respectively; p = 0.27), disease-specific survival (100% vs. 92%, respectively; p = 0.20), or overall survival (100% vs. 89%, respectively; p = 0.34). The differences in chemotherapy utilization did not impact pattern of relapse, specifically peritoneal spread (7% vs. 6%, respectively; p = 0.92) or other distant sites (0% vs. 9%, respectively; p = 0.17). Conclusions Oncologic outcomes and recurrence patterns of women with stage I–II uterine clear cell carcinoma compared favorably with those of women with serous carcinoma, despite significantly less adjuvant chemotherapy use. Potential reduction in adjuvant therapy in women with clear cell carcinoma should be studied prospectively.
DIRECT PLANIMETRY OF LEFT VENTRICULAR OUTFLOW TRACT AREA BY SIMULTANEOUS BIPLANE IMAGING: CHALLENGING THE NEED FOR A CIRCULAR ASSUMPTION OF LEFT VENTRICULAR OUTFLOW TRACT AREA IN CALCULATING AORTIC VALVE AREA

Aortic valve area (AVA) and LV stroke volume index (SVi) calculations assume a circular-shaped LV outflow tract (LVOT). However, the LVOT is often ellipsoid rather than circular, resulting in underestimation of the true LVOT area. Biplane imaging of LVOT allows direct planimetry of LVOT area. We
Classification of in-plane failure modes for reinforced concrete frames with infills using machine learning

Abstract The failure modes of reinforced concrete frame structures with masonry infill panels have strong implications to their overall seismic performance . This paper explores a data-driven approach to classifying the in-plane failure modes of infill frames by employing machine learning methods . To this end, an experimental database consisting of 114 infill frame specimens is constructed. Six machine learning algorithms are implemented and evaluated for failure-mode classification using nine structural parameters as input variables. The validation results indicate that most of the models are able to achieve more than 80% prediction accuracy, with the highest accuracy of 85.7% achieved by the Adaptive Boosting and Support Vector Machine algorithms.
Hip Joint Pain

The hip is a ball-and-socket joint with robust muscular attachments. Hip pain can originate from spinal, intra-articular, and systemic pathologic issues which often renders diagnosis difficult. Range of motion deficits, specific physical exam tests, and radiographic imaging are useful for developing a differential diagnosis.
Parametric and Autoparametric Dynamics of Ships with Liquid Sloshing Interaction

Two mechanisms of parametric roll resonance of navigating ships together with roll-pitch autoparametric interaction of ship dynamics are outlined. Deterministic and stochastic parametric roll ship’s stability are outlined. Sloshing flow in liquid ship cargo adds additional problem in the vessel stability and dynamics. A liquid cargo tank is excited by the ship motion and the subsequent liquid sloshing flow itself affects the ship dynamics. The problem of ship interaction with liquefied natural gas (LNG) sloshing dynamics is discussed. Ship designers have been motivated to develop passive and active controls of ships roll instability. This includes free surface anti-roll tanks and U-tube anti-roll tanks. The basic principle of the two anti-roll tank types is to transfer the liquid from starboard to port side and vice versa, with a certain phase lag with respect to the ship’s rolling motion. This provides a counteracting moment to stabilize the ship roll oscillations. This article is dedicated in memory of two outstanding leaders in the field of nonlinear dynamics: the late Professor Ali H. Nayfeh and the late Professor Allan D. S. Barr.
A Friction-Based Kinematic Model for Skid-Steer Wheeled Mobile Robots

Skid-steer drive systems are widely used in mobile robot platforms. Such systems are subject to significant slippage and skidding during normal operation due to their nature. The ability to predict and compensate for such slippages in the forward kinematics of these types of robots is of great importance and provides the means for accurate control and safe navigation. In this work, we propose a new kinematic model capable of slip prediction for skid-steer wheeled mobile robots (SSWMRs). The proposed model outperforms the state-of-the-art in terms of both translational and rotational prediction error on a dataset composed of more than 6 km worth of trajectories traversed by a skid-steer robot. We also publicly release our dataset to serve as a benchmark for system identification and model learning research for SSWMRs.
Innovative Teaching for Real-World Capstone Experience in Apparel Production

The textiles and apparel industry is one of the most globalized, dynamic, and labor intensive businesses with various sectors of production providing jobs for millions of people worldwide. Due to these reasons, it is important to understand the industry demands and prepare students for these industry needs. Institutions need to consider curriculum development according to the professions involved primarily in the product development process, the production process, and the distribution process. The purpose of this paper is to provide insights to instructors who teach the main two areas; apparel product development and production, especially as capstone series, in their curriculum development.
Chapter 5 – Reactions and Energy Relationships

In chemistry, reactions occur as the result of energy changes. Specifically, the free energy change, ΔG, must be negative for a reaction to be spontaneous. Free energy change is related to the equilibrium constant, K, by the relationship, ΔG = −RT ln K. In many cases where the reaction does not involve a change in the number of moles of gaseous reactants or products, the enthalpy change, ΔH, is often useful for predicting spontaneity of reactions. The enthalpy change can be estimated from the difference between the energy required to break bonds and that released when bonds form. Some of the most important types of reactions are combination, replacement, metathesis, and neutralization.
Nuclear Resonance Fluorescence in Ni 60

The gamma radiation emitted by a gaseous source of ${\mathrm{Co}}^{60}$${\mathrm{Cl}}_{2}$ has been used to excite the 1.33-Mev level in ${\mathrm{Ni}}^{60}$. The angular distribution of the resonance radiation characterizes the spin of the 1.33-Mev excited state as 2 and the spin of the ${\mathrm{Ni}}^{60}$ ground state as 0.A resonance fluorescence self-absorption experiment has been performed and from it a mean life of (1.1\ifmmode\pm\else\textpm\fi{}0.2)\ifmmode\times\else\texttimes\fi{}${10}^{\ensuremath{-}12}$ second has been calculated for the 1.33-Mev excited state of ${\mathrm{Ni}}^{60}$.
Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function.

The e4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for Alzheimer's disease (AD) and multiple vascular conditions. ApoE is abundantly expressed in multiple brain cell types, including astrocytes, microglia, and vascular mural cells (VMCs). Here, we show that VMC-specific expression of apoE4 in mice impairs behavior and cerebrovascular function. Expression of either apoE3 or apoE4 in VMCs was sufficient to rescue the hypercholesterolemia and atherosclerosis phenotypes seen in Apoe knockout mice. Intriguingly, vascular expression of apoE4, but not apoE3, reduced arteriole blood flow, impaired spatial learning, and increased anxiety-like phenotypes. Single-cell RNA sequencing of vascular and glial cells revealed that apoE4 in VMCs was associated with astrocyte activation, while apoE3 was linked to angiogenic signature in pericytes. Together, our data support cell-autonomous effects of vascular apoE on brain homeostasis in an isoform-dependent manner, suggesting a critical contribution of vascular apoE to AD pathogenesis.
Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N2-ethenodeoxyguanosine by human DNA translesion polymerase η.

Etheno (e)-adducts, e.g., 1,N2-e−guanine (1,N2-e-G) and 1,N6-e−adenine (1,N6-e-A), are formed through the reaction of DNA with metabolites of vinyl compounds or with lipid peroxidation products. These lesions are known to be mutagenic, but it is unknown how they lead to errors in DNA replication that are bypassed by DNA polymerases. Here we report the structural basis of misincorporation frequencies across from 1,N2-e-G by human DNA polymerase (hpol) η. In single-nucleotide insertions opposite the adduct 1,N2-e-G, hpol η preferentially inserted dGTP, followed by dATP, dTTP, and dCTP. This preference for purines was also seen in the first extension step. Analysis of full-length extension products by LC-MS/MS revealed that G accounted for 85% of nucleotides inserted opposite 1,N2-e-G in single base insertion, and 63% of bases inserted in the first extension step. Extension from the correct nucleotide pair (C) was not observed, but the primer with A paired opposite 1,N2-e-G was readily extended. Crystal structures of ternary hpol η insertion-stage complexes with nonhydrolyzable nucleotides dAMPnPP or dCMPnPP showed a syn orientation of the adduct, with the incoming A staggered between adducted base and the 5’-adjacent T, while the incoming C and adducted base were roughly coplanar. The formation of a bifurcated H-bond between incoming dAMPnPP and 1,N2-e-G and T, compared with the single H-bond formed between incoming dCMPnPP and 1,N2-e-G, may account for the observed facilitated insertion of dGTP and dATP. Thus, preferential insertion of purines by hpol η across from etheno adducts contributes to distinct outcomes in error-prone DNA replication.
p53 Frameshift Mutations Couple Loss-of-Function with Unique Neomorphic Activities.

p53 mutations that result in loss of transcriptional activity are commonly found in numerous types of cancer. While the majority of these are missense mutations that map within the central DNA-binding domain, truncations and/or frameshift mutations can also occur due to various nucleotide substitutions, insertions, or deletions. These changes result in mRNAs containing premature stop codons that are translated into a diverse group of C-terminally truncated proteins. Here we characterized three p53 frameshift mutant proteins expressed from the endogenous TP53 locus in U2OS osteosarcoma and HCT116 colorectal cancer cell lines. These mutants retain intact DNA-binding domains but display altered oligomerization properties. Despite their abnormally high expression levels, they are mostly transcriptionally inactive and unable to initiate a stimuli-induced transcriptional program characteristic of wild-type p53. However, one of these variant p53 proteins, I332fs*14, which resembles naturally expressed TAp53 isoforms β and γ, retains some residual antiproliferative activity and can induce cellular senescence in HCT116 cells. Cells expressing this mutant also display decreased motility in migration assays. Hence, this p53 variant exhibits a combination of loss-of-gain and gain-of-function characteristics, distinguishing it from both wild type p53 and p53 loss. Implications: p53 frameshift mutants display a mixture of residual antiproliferative and neomorphic functions that may be differentially exploited for targeted therapy.
Friends, Fans, and Followers: Do Ads Work on Social Networks?

ABSTRACT Social-networking sites (SNS) such as Facebook and Twitter are growing in both popularity and number of users. For advertisers and the sites themselves, it is crucial that users accept advertising as a component of the SNS. Anecdotal evidence indicates that social-networking advertising (SNA) can be effective when users accept it, but the perception of excessive commercialization may lead to user abandonment. Empirical support for these propositions, however, is lacking. Based on media uses and gratification theory, the authors propose and empirically test a model of content-related, structural, and socialization factors that affect users9 attitudes toward SNA.
Midtrimester abortion induced by hyperosmolar urea and prostaglandin F2α in patients with previous cesarean section: Clinical course and potential for uterine rupture

Abstract Reviewed was the clinical course of 76 patients with a history of previous cesarean section from among 1,626 patients undergoing midtrimester abortion induced with intra-amniotic hyperosmolar urea and prostaglandin F 2α . The cesarean section group had long injection-abortion intervals, more frequently received additional oxytocin for augmentation, and more frequently experienced incomplete abortion. Also, one patient experienced a uterine rupture. A review of the literature dealing with uterine rupture subsequent to induced midtrimester abortion revealed that the typical patient was older and multiparous, had an injection-abortion interval of more than 24 hours, and had received intravenous oxytocin continuously for more than 12 hours. Although there has been no previous report of a uterine rupture with midtrimester abortion in patients who have undergone a prior cesarean section, because of the present findings, such patients require careful monitoring and the judicious use of oxytocic agents.
Chimeric molecules to target proteins for ubiquitination and degradation.

Abstract Protein degradation is one of the tactics used by the cell for irreversibly inactivating proteins. In eukaryotes, ATP‐dependent protein degradation in the cytoplasm and nucleus is carried out by the 26S proteasome. Most proteins are targeted to the 26S proteasome by covalent attachment of a multiubiquitin chain. A key component of the enzyme cascade that results in attachment of the multiubiquitin chain to the target or labile protein is the ubiquitin ligase that controls the specificity of the ubiquitination reaction. Defects in ubiquitin‐dependent proteolysis have been shown to result in a variety of human diseases, including cancer, neurodegenerative diseases, and metabolic disorders. The SCF (Skp1‐Cullin‐F‐box‐Hrt1) complex is a heteromeric ubiquitin ligase that multiubiquitinates proteins important for signal transduction and cell cycle progression. A technology was developed known as Protac (Proteolysis Targeting Chimeric Molecule) that acts as a bridge, bringing together the SCF ubiquitin ligase with a protein target, resulting in its ubiquitination and degradation. The Protac contains an SCF‐binding peptide moiety at one end that is recognized by SCF that is chemically linked to the binding partner or ligand of the target protein. The first demonstration of the efficacy of Protac technology was the successful recruitment, ubiquitination, and degradation of the protein methionine aminopeptidase‐2 (MetAP‐2) through a covalent interaction between MetAP‐2 and Protac. Subsequently, we demonstrated that Protacs could effectively ubiquitinate and degrade cancer‐promoting proteins (estrogen and androgen receptors) through noncovalent interactions in vitro and in cells. Finally, cell‐permeable Protacs can also promote the degradation of proteins in cells. This chapter includes experiments to test the ability of Protacs to target proteins in vitro and in cells.
COAGULASE-NEGATIVE MUTANTS OF STAPHYLOCOCCUS AUREUS: GENETIC STUDIES

Korman, Ruth Z. (Cornell University, Ithaca, N.Y.). Coagulase-negative mutants of Staphylococcus aureus: genetic studies. J. Bacteriol. 86:363-369. 1963.-The behavior in mutation and transduction of pleiotropic coagulase-negative mutants of Staphylococcus aureus PS 53 (NCTC 8511) was analyzed. Coagulase-positive colonies were recovered, as well as a novel phenotype resistant to some cell-wall inhibitors and differing in sugar fermentation pattern. The hypothesis that the coagulase-negative strains differ from the original propagating strain in the structure or organization of the cell wall is discussed.
A Study of Online Social Network Privacy Via the TAPE Framework

While personal information privacy is threatened by online social networks, researchers are seeking for privacy protection tools and methods to assist online social network users. In this paper, we propose a Trust-Aware Privacy Evaluation framework, called TAPE, aiming to address this problem. Under the TAPE framework we investigate how to quantitatively evaluate the privacy risk, as a function of people's awarenesses of privacy risks as well as whether people can be trusted by their friends to protect others' personal information. Simulations are performed to illustrate the key concepts and calculations, as well as the advantages of TAPE. Based on the TAPE framework, we also propose an unfriending strategy in terms of privacy protection, which outperforms other existing unfriending strategies.
A note on the regularity of reduced models obtained by nonlocal quasi-continuum-like approaches

The paper investigates model reduction techniques that are based on a nonlocal quasi-continuum-like approach. These techniques reduce a large optimization problem to either a system of nonlinear equations or another optimization problem that are expressed in a smaller number of degrees of freedom. The reduction is based on the observation that many of the components of the solution of the original optimization problem are well approximated by certain interpolation operators with respect to a restricted set of representative components. Under certain assumptions, the “optimize and interpolate” and the “interpolate and optimize” approaches result in a regular nonlinear equation and an optimization problem whose solutions are close to the solution of the original problem, respectively. The validity of these assumptions is investigated by using examples from potential-based and electronic structure-based calculations in Materials Science models. A methodology is presented for using quasi-continuum-like model reduction for real-space DFT computations in the absence of periodic boundary conditions. The methodology is illustrated using a basic Thomas–Fermi–Dirac case study.
Cost Effectiveness of a Potential Vaccine for Human papillomavirus

Human papillomavirus (HPV) infection, usually a sexually transmitted disease, is a risk factor for cervical cancer. Given the substantial disease and death associated with HPV and cervical cancer, development of a prophylactic HPV vaccine is a public health priority. We evaluated the cost-effectiveness of vaccinating adolescent girls for high-risk HPV infections relative to current practice. A vaccine with a 75% probability of immunity against high-risk HPV infection resulted in a life-expectancy gain of 2.8 days or 4.0 quality-adjusted life days at a cost of $246 relative to current practice (incremental cost effectiveness of $22,755/quality-adjusted life year [QALY]). If all 12-year-old girls currently living in the United States were vaccinated, >1,300 deaths from cervical cancer would be averted during their lifetimes. Vaccination of girls against high-risk HPV is relatively cost effective even when vaccine efficacy is low. If the vaccine efficacy rate is 35%, the cost effectiveness increases to $52,398/QALY. Although gains in life expectancy may be modest at the individual level, population benefits are substantial.
An uncertainty relation for joint position-momentum measurements

It is shown that the lower bound in the uncertainty relation for joint position-momentum measurements is twice as large as that in the usual Heisenberg uncertainty principle for separate measurements.
The thermal properties of inorganic compounds III. Strontium chloride 6-hydrate

Abstract The TG, DTG, DTA, DSC, EC and dilatometric curves of SrCi2-6H2O are presented. Intermediate hydrates having the composition, SrCl2-2H2O and SrCl2-H2O, were detected while there was evidence for SrCl2-0.5H2O in the high pressure DSC curves. DSC curves for this compound were obtained at pressures from 0.2 to 50 atm.
Rotational excitation of CO in a cool, mixed atomic and molecular hydrogen gas

Context. Rate constants for rotational excitation of CO by atomic hydrogen have recently been recalculated and found to be much larger than was previously believed, larger even than for excitation by H 2 . Aims. To clarify the effect upon CO rotational excitation of an admixture of atomic hydrogen in diffuse molecule-bearing gas. Methods. The equations of statistical equilibrium in the CO rotation ladder are solved under a variety of conditions typical of CO-bearing gas in the diffuse ISM. Results. Atomic hydrogen, if present, substantiantially increases the brightness and excitation temperatures of the CO rotational transitions, and increases the J = 2-1/J = 1-0, J = 3-2/J = 2-1, etc. line brightness ratios. A modest admixture of atomic hydrogen mimics a pure H 2 -gas of substantially higher ambient thermal pressure. Conclusions. Rotational excitation of CO by atomic hydrogen is important if even a few percent of the hydrogen is in atomic form.
A quantitative study of the relation of synthetic 3-pentadecyl catechol to hypersensitiveness to rhus toxicodendron (poison ivy) as shown by the patch test

Abstract 1.1. Sixty-two persons sensitive to the poison ivy plant were found to be sensitive to synthetic 3-pentadecyl catechol in concentrations of 1 per cent, or less, in acetone. This substance is the saturated analogue of the active ingredient causing poison ivy dermatitis. 2.2. Quantitative studies in twenty-one subjects sensitive to poison ivy showed that a 0.1 per cent concentration of 3-pentadecyl catechol in acetone is suitable to detect those sensitive to the poison ivy plant, and probably also, related plants; however, for final evaluation a period of ninety-six hours of observation is requisite. The advantage of using this concentration is that severe reactions are eliminated for the most part. There are occasional instances in which, after ninety-six hours, a 1 per cent concentration may be used to reveal the exceptionally mildly sensitive patient who fails to react to a 0.1 per cent concentration. 3.3. The advantages of using synthetic 3-pentadecyl catechol as a replacement for ground poison ivy leaves or extract in testing for hypersensitiveness to Rhus toxicodendron have been pointed out. It is suggested that in a suitable vehicle and concentration this substance may be used in an attempt to desensitize persons sensitive to the poison ivy plant and its congeners. 4.4. The principle of group specific reactions is amply illustrated in the case of 3-pentadecyl catechol in its relation to the active ingredient in poison ivy dermatitis.
SV40 VP1 assembles into disulfide-linked postpentameric complexes in cell-free lysates.

Abstract The simian virus 40 (SV40) capsid is composed of pentameric capsomeres of the major structural protein, Vp1. The chemical nature of Vp1-Vp1 interactions, as well as the role of the minor structural proteins, Vp2 and Vp3, in SV40 assembly is not clear. We show here that Vp1 molecules synthesized in rabbit reticulocyte lysates self-assembled into postpentameric 12S complexes in the absence of other viral structural proteins and in a time and concentration dependent manner. The 12S complexes were resistant to perturbants of noncovalent interactions but were sensitive to reduction by dithiothreitol. Nonreducing SDS-PAGE analysis revealed disulfide-linked VP1 complexes of >400 kDa. Our results are consistent with crystallography studies of SV40 which suggest involvement of disulfide bonds at a postcapsomeric stage of viral assembly.
THE EFFECT OF RACE OF EXAMINER ON THE MENTAL TEST SCORES OF WHITE AND BLACK PUPILS1

An entire elementary school system with 60% white and 40% black pupils was given several abiity tests group-administered by 12 white and eight black examiners (Es). The tests measured verbal and nonverbal IQ, perceptual-motor cognitive development, “speed and persistence” under neutral and motivating instructions, listening-attention, and short-term rote memory for numbers. With the exception of the “speed and persistence” test, on which white Es yielded significantly and consistently higher mean scores than black Es for both white and black pupils across grades one to six, the results for the various cognitive ability tests showed that the race of the E did not produce large or consistent effects in the testing of white and black pupils.
Effects of multiple sequential extracorporeal shock wave treatments on renal function : a primate model

As extracorporeal shock wave lithotripsy (SWL) has been used for stones of increasing size, there has emerged a need for multiple treatments to fragment the stone adequately, and there has been some concern about the effect of these sequential treatments on renal function. No long-term studies are available as to the timing of a second or third treatment, nor of the effects on the individual kidney. We used six adult Rhesus monkeys (Macaca mulatta). The first group (N = 3) was treated with 2500 shocks at 28 kV to one kidney and the next group (N = 3) was treated with 2000 shocks at 18 kV at weekly intervals for 3 weeks. The animals were followed with quantitative renal camera studies prior to treatment, 48 hours after treatment, then weekly for 3 weeks, at 3 months, and at 6 months. The animals in the single-treatment group had a change in effective renal plasma flow (ERPF) of 2 ml/min per m2, which was equal to baseline (P > 0.1). In the multiple treatment group, there was a slight rise of ERPF (1 ml/min...
MRI of pulmonary embolism using Gd-DTPA-polyethylene glycol polymer enhanced 3D fast gradient echo technique in a canine model

Abstract This study was to evaluate the accuracy of MR angiography (MRA) using a Gd-DTPA-polyethylene glycol polymer (Gd-DTPA-PEG) with a 3D fast gradient echo (3D fgre) technique in diagnosing pulmonary embolism in a canine model. Pulmonary emboli were created in six mongrel dogs (20–30 kg) by injecting tantalum oxide-doped autologous blood clots into the femoral veins via cutdowns. MRI was performed with a 1.5 T GE Signa imager using a 3D fgre sequence (11.9/2.3/15°) following intravenous injection of 0.06 mmol Gd/kg of Gd-DTPA-PEG. The dogs were euthanized and spiral CT of the lungs were then obtained on the deceased dogs. The MRI images were reviewed independently and receiver-operating-characteristic (ROC) curves were used for statistical analysis using spiral CT results as the gold standard. The pulmonary emboli were well visualized on spiral CT. Out of 108 pulmonary segments in the six dogs, 24 contained emboli >2 mm and 27 contained emboli ≤2 mm. With unblinded review, MRI detected 79% of emboli >2 mm and only 48% of emboli ≤2 mm. The blinded review results were significantly worse. Gd-DTPA-PEG enhanced 3D fgre MRI is potentially able to demonstrate pulmonary embolism with fairly high degree of accuracy, but specialized training for the interpretations will be required.
Estrogen production and its origin in men with gonadotropin-producing neoplasms.

ABSTRACT Urinary estradiol production rates were found to be elevated in 6 consecutive men with gonadotropin-producing tumors (4 with choriocarcinoma, and 2 with ectopic gonadotropinproducing tumors of stomach and lung). The ranged from 63 to 605 μg/day (1½- to 15-fold elevated) and correlated with gonadotropin production and tumor mass. To determine the origin of the elevated E2, 3H dehydroepiandrosterone sulfate (DHEA-SO4) was given iv and its conversion to urinary E2 determined by reverse isotope methods. The transfer constant ranged from 0.5 to 11.0% and increased as the increased. Control cancer patients had ρ values of <0.2%. Metabolism of DHEA-SO4 to E2 accounted for all of the increased in patients making greater than 100 μg/day of E2. Primary tumor tissue and metastatic nodules from 1 patient with choriocarcinoma were incubated with either 3H-DHEA or 3H-DHEA-SO4 and conversion of these substrates to estrone and estradiol was shown by reverse isotope dilution and crystallization methods, confirmin...
An Empirical Comparison of Three Indices of Factorial Similarity

The need for an adequate methodological resolution to the factor-matching (invariance) problem—long recognized as critical by theoretically oriented factor analysts—is also being strongly felt by a...
Generalized models of design iteration using signal flow graphs

Cover title. "An earlier form of this paper was presented at the 1995 ASME Conference on Design Theory and Methodology."
Analytical and experimental investigation of burnout in creep-feed grinding

Creep-feed grinding operations require a copious fluid flow for cooling at the grinding zone. Cooling effectiveness in creep-feed grinding depends upon a critical burn-out limit beyond which fluid film boiling occurs, cooling becomes ineffective, and the temperature rises catastrophically. In the present paper, a thermal analysis is presented to predict the burn-out heat flux limit at a critical temperature for film boiling. The thermal model considers the transient workpiece and fluid temperatures during a grinding pass and the energy partition to the workpiece. Measurements of the burn-out heat flux are found to be in good agreement with theoretical predictions over a wide range of creep-feed grinding conditions.
Effects of complaining versus negative word of mouth on subsequent changes in satisfaction: The role of public commitment

This research reviews the motivation for voice behavior by dissatisfied consumers and demonstrates that facilitating complaining behavior results in reduced levels of negative word-of-mouth activity. Support is found for the hypotheses that dissatisfied consumers who complain to the marketer will experience venting-induced reduction in dissatisfaction, and that they will engage in reduced levels of negative word of mouth. On the other hand, dissatisfied consumers who engage in the relatively public act of negative word of mouth become committed to their level of dissatisfaction and hence do not exhibit any subsequent venting-induced reduction in dissatisfaction. The role of public commitment in binding individuals to their prior evaluations is discussed, along with the managerial implications. © 2005 Wiley Periodicals, Inc.