cssi/SciSciGPT-SciSciNet huggingface dataset:
THE GHISELLI SELF-DESCRIPTION INVENTORY AS A PREDICTOR OF MANAGERIAL SUCCESS

Summary.-A group of middle managers in two medium-sized business enterprises completed the Ghiselli Self-description Inventory, an empirically based instrument designed to identify the traits and talents of successful managers. These middle managers were also evaluated by heir vice presidents as ro whether they had achieved enough success to warrant consideration for promotion. The Inventory failed to distinguish between those who were successful (n = 11) and those who were unsuccessful (n = 13) managers. The GhiseUi Self-description Inventory is an instrument designed to measure managerial talent and ". . . the greater the individual's managerial talent, the more likely he is to succeed as a manager at the lower levels, and the higher is the probability that he ultimately would reach the highest levels of management" (Ghiselli, 1971, p. 102). The research literature, however, presents a differing opinion of the instrument in outright rejection by Frederiksen, Jensen, and Beaton (1972). Brief, Aldag, and Chadco (1977) also did not find any correlation between the instrument and the Miner Sentence completion Scale. This is significant since Miner equates his instrument with manager's success stating ". . . the MSCS total scores repeatedly yield a positive relationship with a whole range of managerial success indexes" (Miner, 1965, p. 231). However, Miner (1978) presented correlations with the instrument and his sentence completion. This is significant since Miner states his instrumentL". . . is most precisely defined as a measure of motivation to manage, to behave in ways which are role relevant insofar as managerial work is concerned'' (Miner, 1965, p. 52). He assumes that managerial work in hierarchically structured organizations such as found in American industry satisfies the desire to compete for and exercise power .over other people. Those individuals with high scale scores would be expected to move more rapidly than others into higher level positions where greater opportunity exists to obtain satisfaction for their desire for power. In a test of the concurrent validity of the scale Miner concluded "Those with the motivation appropriate to managerial work have achieved higher occupational levels, are considered to be more effective in their present positions, and are rated as having greater potential for further promotion" (Miner, 1965, p. 56). At the conclusion of a test of predictive validity Miner reaffirms, "There is some basis for concluding that those with role relevant motivation, and thus a
Simulation of carbon-13 nuclear magnetic resonance spectra of quinolines and isoquinolines

Abstract The 13 C NMR spectra for a series of amino-, nitro-, dichloro-, chloro- and chloromethylquinolines and isoquinolines were simulated using computer-aided methodology. Numerical descriptors were calculated to encode structural features about each carbon center. Multiple linear regression techniques were used to generate four models relating these descriptors to the observed 13 C NMR chemical shifts, and these models were then used to simulate the complete observed 13 C NMR spectra. The resulting spectra had an rms error of 2.7 ppm and were matched with the experimental spectra during library searches. Simulated spectra for an external prediction set were generated and evaluated. The quality of the simulation results depends primarily on the ring substituents rather than the position of the nitrogen in the backbone.
Dynamics of the plume containing nanometric-sized particles ejected into the atmospheric air following laser-induced breakdown on the exit surface of a CaF2 optical window

Laser induced breakdown on the output surface of calcium fluoride produces distinctive visualization of the gaseous material ejection via time-resolved shadowgraphy microscopy. This characteristic behavior allowed a detailed investigation of the directional expansion of the plume at ambient atmospheric conditions and its spatial separation and influence on the forming shockwave. The results also suggest that the material ejection is prolonged, extending more than 300 ns after the termination of the laser pulse. The dynamics of the backward motion of the gaseous material following its initial expansion is also resolved.
Evidence of allergy in patients with cystic fibrosis of the pancreas.

Abstract Review of the records of 135 patients with cystic fibrosis of the pancreas revealed that nineteen had evidence of atopic allergy. The diagnosis of cystic fibrosis was easily overlooked in patients with classical manifestations of atopic allergy, such as asthma, nasal polyps, hay fever, urticaria, eczema, positive skin tests, and familial allergy. Optimal therapy for many of these patients included treatment of the allergic problem as well as the usual regiment for cystic fibrosis. Forty-seven patients with atopic bronchial asthma had no evidence of the sweat chloride abnormality characteristic of cystic fibrosis of the pancreas. The nature of the relationship between cystic fibrosis of the pancreas and atopic allergy is not clear.
Large-magnitude continental extension: An example from the central Mojave metamorphic core complex

The central Mojave metamorphic core complex is defined by a belt of Miocene brittle-ductile extension and coeval magmatism. The brittle-ductile fault zone defines a basin-and-dome geometry that results from the interference of two orthogonal fold sets that we infer to have formed by mechanically independent processes. One fold set contains axes that lie parallel to the extension direction of the shear zone and has a maximum characteristic wavelength of about 10 km. The axial surfaces of these folds can be traced from the footwall mylonites, through the brittle detachment, and into hanging-wall strata. However, folds of mylonitic layering have smaller interlimb angles than those of the brittle detachment, suggesting that the folds began to form during ductile shearing and continued to amplify in the brittle regime, possibly after movement across the fault zone ceased. Mesoscopic fabrics related to the transport-parallel fold set indicate that the folds record true crustal shortening perpendicular to the extension direction. We interpret these folds to form in response to elevated horizontal compressive stress perpendicular to the extension direction and suggest that this stress regime may be a natural consequence of large-magnitude extension. The other fold set has axes perpendicular to the extension direction and a characteristic maximum wavelength of about 50 km. Mesoscopic fabrics related to these folds include northwest-striking joints, kink bands, and en echelon tension-gash arrays. These fabrics formed after mylonitization and record both layer-parallel extension and northeast-side-up subvertical shear. The postmylonitic fabrics are kinematically compatible with rolling-hinge-style isostatic rebound of the footwall following tectonic denudation. The relative timing of extension-related magma intrusion and ductile deformation varies through the central Mojave metamorphic core complex. On the scale of the small mountain ranges that make up the central Mojave metamorphic core complex, no correlation was observed between either shear zone thickness or intensity of ductile deformation and either the proximity or relative volume of extension-related igneous rocks. This suggests that models that invoke a single upper-crustal genetic relationship, such as magmatism triggering extension or vice versa, do not apply to the central Mojave metamorphic core complex. Systematic variation in the relative timing of dike emplacement and mylonitization suggests that, at the time of dike emplacement, rocks in the Mitchel Range were below the brittle-ductile transition while those in the Hinkley Hills were above it. The Hinkley Hills and Mitchel Range are separated by ∼2 km in the dip direction of the fault zone, which suggests that the vertical thickness of the brittle-ductile transition probably was between 100 and 950 m.
The fractal dimension of the wind

In this paper the concept of a fractal and its dimension is presented. The fractal dimension of the horizontal component of several wind speed time series is determined by the variation method. It is concluded that the fractal dimensions D=1.60 can be used to describe the wind both at Windsor, MA, and Altamont, CA. The fractal dimension is related to the universal estimate of the decay rate of turbulent kinetic energy in the wind.
Uniform and $L^2$ convergence in one-dimensional stochastic Ising models

We study the rate of convergence to equilibrium of one dimensional stochastic Ising models with finite range interactions. We donot assume that the interactions are ferromagnetic or that the flip rates are attractive. The infinitesimal generators of these processes all have gaps between zero and the rest of their spectra. We prove that if one of these processes is observed by means of local observables, then the convergence is seen to be exponentially fast with an exponent that is any number less than the spectral gap. Moreover this exponential convergence is uniform in the initial configuration.
Differential regulation of muscarinic and nicotinic receptors by cholinergic stimulation in cultured avian retina cells

Sustained cholinergic stimulation of retina cells grown in primary aggregate and monolayer cultures regulated the concentration of muscarinic but not nicotinic receptors. Muscarinic receptor sites, quantified by the binding of [3H]quinuclidinyl benzilate to membranes and the binding of [3H]N-methyl-scopolamine to intact cells, decreased up to 84% following long-term incubation of cultures in muscarinic agonists. This decrease was blocked by atropine and was not induced by chronic nicotine treatment. The rate of the muscarinic response was biphasic. A rapid binding decrease of 30% occurred within 15 min. The slower phase was half-maximal by 6 h and was complete by 24 h. Neither the fast nor the slow receptor loss was reversed by the guanine nucleotide GppNp. Three different depolarizing agents (gramicidin D, protoveratrine, and ouabain) blocked the cholinergic-induced receptor loss, but the hyperpolarizing ionophore valinomycin had no effect. In contrast to the muscarinic response, nicotinic receptor binding was not altered by chronic receptor stimulation. Exposure to receptor-saturating doses of carbamylcholine or nicotine for 48 h did not change [125I]alpha-bungarotoxin or [3H]bromoacetylcholine binding. Differential regulation of acetylcholine receptors is discussed in relation to the possible physiological role of receptor regulation by receptor activity.
Control by exclusion in arbitrary matching-to-sample

Abstract Eight handicapped youths were taught arbitrary matching between visual sample stimuli and visual comparison stimuli: Given Sample A1, selecting Comparison B1 was reinforced; given A2, selecting B2 was reinforced. During nonreinforced test trials consisting of novel samples, novel comparisons, and familiar B comparisons, subjects selected the novel comparisons. Compared to intervening preference tests between novel comparisons, these results suggested that selecting the novel stimuli was controlled by the B comparisons, a phenomenon called exclusion. Some subjects continued to select the same novel comparisons during subsequent preference tests, suggesting that control by exclusion may result in arbitrary matching in new contexts. emonstrated symmetry of AB matching (i.e., BA matching) suggested that A stimuli should also control novel comparison selection; however, these subjects did not show exclusion, but most often selected the A comparisons.
Aminal-catalyzed isomerization of and addition to dimethyl maleate

Abstract The amine moiety of aminals adds to dimethyl maleate via azomethine ylid intermediates. The products of this reaction, in turn, cause dimethyl maleate to isomerize to dimethyl fumarate.
Detecting buried objects by fusing dual-band infrared images

The authors have conducted experiments to demonstrate the enhanced detectability of buried land mines using sensor fusion techniques. Multiple sensors, including visible imagery, infrared imagery, and ground penetrating radar (GPR), have been used to acquire data on a number of buried mines and mine surrogates. Because the visible wavelength and GPR data are currently incomplete, the paper focuses on the fusion of two-band infrared images. The authors use feature-level fusion and supervised learning with the probabilistic neural network (PNN) to evaluate detection performance. The novelty of the work lies in the application of advanced target recognition algorithms, the fusion of dual-band infrared images and evaluation of the techniques using two real data sets. >
A Numerical Framework for Isotropic and Anisotropic Flexible Flapping Wing Aerodynamics and Aeroelasticity

*† ‡ § A numerical framework is presented to simulate rigid and flexible flapping wings. The fluid-structure interaction is realized by coupling a Navier-Stokes solver to a geometrically nonlinear co-rotational structural solver. In the coupled fluid-structure interaction interface the aerodynamic loading and deformed wing surface are shared by two solvers within each time step. A remeshing method based on radial basis function is implemented to handle large deformations, preserve grid quality, and execute economically. Flexible flapping wing operating in both vacuum and air is considered to shed light on inertial and aerodynamic loading-induced shape deformation. Impacts of flapping isotropic wing with single degree of freedom rotation on aerodynamic force generation are presented for Re= 1.5×10 3 and k= 0.56. The results indicate: 1) the flexibility-induced pitching angle promotes thrust generation, and 2) the increase of wing velocity due to large bending motion enhances aerodynamic force by increasing pressure differences. For a wing of anisotropic mechanical properties, highly three-dimensional wing deformation is observed when the wing accelerates or decelerates in absent of aerodynamic loadings.
Spacecraft Film System for Planetary Photography

The mission restraints on a planetary orbital reconnaissance mission will be discussed with particular consideration given to a Mars Voyager type vehicle in the late 60's - early 70's. The mission restraints will then be used to compare two possible systems that can be used: a TV-tape recorder combination, and a photographic system. The problems particular to a photographic system will be expanded upon and the methods to be used in their solution elucidated. Particular among these problems are those associated with the film processing and the protection of the film and developer during the long Earth-Mars transit time. Under investigation is a web type processing machine that has special features to help solve this problem. The machine design will be discussed and some results presented. Discussion of necessary further improvements of this device and development of the other necessary system components may be included if time permits.
Micafungin: pharmacology, experimental therapeutics and clinical applications.

Invasive fungal infections are important causes of morbidity and mortality in hospitalised patients. Current therapy with amphotericin B and antifungal triazoles has overlapping targets and is limited by toxicity and resistance. Echinocandins are a new class of antifungal drugs, which inhibit the synthesis of 1,3-β-D-glucan. This homopolysaccharide is an important component of the cell wall of many pathogenic fungi, providing osmotic stability and functioning in cell growth and cell division. Micafungin, which is a member of the echinocandin class, exhibits invitro fungicidal or fungistatic activity against a variety of fungal pathogens which include Candida and Aspergillus species but not Cryptococcus, Fusarium or Zygomycetes. Micafungin demonstrates linear pharmacokinetics, which are not altered by drugs metabolised through the P450 enzyme system. The preclinical and clinical data strongly support the development of micafungin for treatment of proven or suspected mucosal and invasive Candida infections ...
Weidner receives 2011 Inge Lehmann Medal: Response

Donald J. Weidner was awarded the 2011 Inge Lehmann Medal at the AGU Fall Meeting Honors Ceremony, held on 7 December 2011 in San Francisco, Calif. The medal is for “outstanding contributions to the understanding of the structure, composition, and dynamics of the Earth's mantle and core.”
Near-infrared multispectral scattering for assessing internal quality of apple fruit

Firmness and sweetness are key quality attributes that determine the acceptability of apple fruit to the consumer. The objective of this research was to investigate a multispectral imaging system for simultaneous acquisition of multispectral scattering images from apple fruit to predict firmness and soluble solids content (SSC). A circular broadband light beam was used to generate light backscattering at the surface of apple fruit and scattering images were acquired, using a common aperture multispectral imaging system, from Red Delicious and Golden Delicious apple fruit for wavelengths at 680, 880, 905, and 940 nm. Scattering images were radially averaged to produce one-dimensional spectral scattering profiles, which were then input into a backpropagation neural network for predicting apple fruit firmness and SSC. It was found that the neural network performed best when 10 neurons and 20 epochs were used. With inputing three ratios of spectral profiles involving all four wavelengths, the neural network gave firmness predictions with the correlation (r) of 0.76 and the standard error for validation (SEV) of 6.2 N for Red Delicious apples and r=0.73 and SEV=8.9 N for Golden Delicious apples. Relatively good SSC predictions were obtained for both varieties with SEV=0.9° Brix.
Lymphocyte migration through the lymphatic sinuses of the chicken's lymph node.

Abstract We have described the lymphocyte migration through the sinus wall of the lymph node. The sinuses showing lymphocyte migration are located in a given area of the node that might be comparable with the T-dependent deep cortex of the mammalian lymph nodes. The lymphocyte migration takes place through the cytoplasm of the endothelial cell presumably by formation of the transendothelial channels, which are produced by vesicles of the endothelial cell. The intensive vesiculation preceding the formation of transendothelial channels might indicate the direction of the migration. The absence of vesicles in the endothelial cell and the dilated intercellular space between the lymphocyte and endothelial cell suggest that the lymphocyte in the sinus wall may be “resting”. The presence of the multivesicular body in the pseudopod or in the vicinity of the pseudopod of the lymphocyte may contribute to the migration.
Quantum-chromodynamic gluon contributions to large-p T reactions

We use a calculation based on the lowest order in the perturbation series for quantum chromodynamics to obtain an estimate for the contribution of hard-scattering processes involving vector gluons to the production of hadrons at large transverse momentum. Some simple models for the distribution of gluons in a proton and for the distribution of hadrons within a hard gluon jet are presented and used to calculate the process $\mathrm{pp}\ensuremath{\rightarrow}{\ensuremath{\pi}}^{0}X$. At $\sqrt{s}=53$ GeV we find that the contribution of the subprocess $\mathrm{qV}\ensuremath{\rightarrow}\mathrm{qV}$ is comparable to that of $\mathrm{qq}\ensuremath{\rightarrow}\mathrm{qq}$. The resulting cross sections are rather close to the CERN ISR data in magnitude. It is possible that small corrections arising, for example, from higher-order terms in the perturbation expansion might lead to a detailed fit to these data. At higher energies, such as those to be obtained in proposed new experimental facilities, our results indicate that the mechanisms $\mathrm{VV}\ensuremath{\rightarrow}\mathrm{VV}$ and $\mathrm{qV}\ensuremath{\rightarrow}\mathrm{qV}$ may dominate over $\mathrm{qq}\ensuremath{\rightarrow}\mathrm{qq}$ in much of the accessible kinematic regime. We briefly consider some experimental consequences of possible gluon dominance.
Evaluation of a depression screening and treatment program in primary care for patients with diabetes mellitus: Insights and future directions

Purpose To evaluate a collaborative depression care program by assessing adherence to the program by internal medicine clinic (IMC) staff, and the program's effectiveness in treating depression in patients with diabetes mellitus. We also describe the rate of depression among patients with diabetes in the IMC. Data sources Data for this program were obtained from a deidentified disease registry and included 1312 outpatient IMC visits in adult patients with diabetes between March 2011 and September 2011. Conclusions Collaborative depression care results in high rates of screening for and identification of depression, high rates of antidepressant utilization, and improved depression scores; however, more focused interventions are needed to improve diabetes outcomes in patients with depression and diabetes. Implications for practice The results indicate that the multidisciplinary IMC staff can work together with patients to identify and monitor depression within primary care. This study provides valuable information about models of depression care that can be implemented and evaluated in a clinical setting.
Effect of antihypertensive therapy on progression of carotid intima-media thickness in patients with type 2 diabetes mellitus.

Antihypertensive therapy reduces the incidence of cardiovascular events in people with diabetes mellitus (DM). However, the effects of treatment on subclinical atherosclerosis are less well studied. Results of a post hoc cohort analysis of the association between antihypertensive treatment and carotid artery intima-media thickness (CIMT) in the Troglitazone Atherosclerosis Regression Trial (TART), a randomized trial designed to evaluate the impact of troglitazone treatment on CIMT progression in adults with insulin-requiring type 2 DM, are reported. CIMT, blood pressure (BP), and use of antihypertensive agents were measured throughout the 2-year treatment period. In multivariable mixed-effects models, the annual rate of change in CIMT in relation to BP and duration of antihypertensive agent use, adjusting for covariates, was evaluated. Higher systolic BP was associated with a higher CIMT progression rate (p = 0.03). This association was reduced by antihypertensive treatment in a duration-dependent manner (p for interaction = 0.035). Adjustment for age, treatment assignment, and change in fasting glucose during the trial did not attenuate these associations. In conclusion, regular use of antihypertensive agents reduces the harmful impact of increased BP on atherosclerosis progression in patients with DM. The antiatherogenic effect of antihypertensive agents, including BP normalization and possible direct vascular wall protection, can be detected by CIMT progression using B-mode ultrasound in patients with DM.
A method for estimating the analysis error variance in a physical space data assimilation system

The error variance of a meteorological analysis is an important quantity, both as a measure of confidence in the analysed product, and as an initial condition for the forecast error variance in a cycling data assimilation system. Modem assimilation systems that rely on global solutions of the analysis equations typically do not include an estimate of this quantity, even though the equation for the full analysis error covariance matrix is well-known. The reason is that this equation is far too costly to implement directly. In this article we analyse the analysis error covariance equation of the Kalman filter, and we propose a computationally efficient method for estimating the analysis error variance, i.e. the diagonal elements of the covariance matrix. The estimate is shown to be conservative in the sense that the analysis error variance is overestimated everywhere. We illustrate the performance of the method in the context of simple two-dimensional analysis experiments as well as in a global, three-dimensional ozone data assimilation system. These experiments show that both quantitatively and qualitatively the method captures the main features of the variance calculated by the full covariance equation at a small fraction of the cost.
Contrasting approaches to a theory of learning

The general process view of learning, which guided research into learning for the first half of this century, has come under attack in recent years from several quarters. One form of criticism has come from proponents of the so-called biological boundaries approach to learning. These theorists have presented a variety of data showing that supposedly general laws of learning may in fact be limited in their applicability to different species and learning tasks, and they argue that the limitations are drawn by the nature of each species' adaptation to the particular requirements of its natural environment. The biological boundaries approach has served an important critical function in the move away from general process learning theory, but it is limited in its ability to provide an alternative to the general process approach. In particular, the biological boundaries approach lacks generality, it is in some respects subservient to the general process tradition, and its ecological content is in too many cases limited to ex post facto adaptive explanations of learning skills. A contrasting, ecological approach to learning, which can provide a true alternative to general process theory, is presented. The ecological approach begins by providing an ecological task description for naturally occurring instances of learning; this step answers the question: What does this animal learn to do? The next step is an analysis of the means by which learning occurs in the course of development, answering the question : How does the animal learn to do this? On the basis of such analyses, local principles of adaptation are formulated to account for the learning abilities of individual species. More global principles are sought by generalization among these local principles and may form the basis for a general ecological theory of learning.
Solution to the perturbative infrared catastrophe of hot gauge theories

The free energy of a nonabelian gauge theory at high temperature $T$ can be calculated to order $g^5$ using resummed perturbation theory, but the method breaks down at order $g^6$. A new method is developed for calculating the free energy to arbitrarily high accuracy in the high temperature limit. It involves the construction of a sequence of two effective field theories by first integrating out the momentum scale $T$ and then integrating out the momentum scale $g T$. The free energy decomposes into the sum of three terms, corresponding to the momentum scales $T$, $gT$, and $g^2T$. The first term can be calculated as a perturbation series in $g^2(T)$, where $g(T)$ is the running coupling constant. The second term in the free energy can be calculated as a perturbation series in $g(T)$, beginning at order $g^3$. The third term can also be expressed as a series in $g(T)$ beginning at order $g^6$, with coefficients that can be calculated using lattice simulations of 3-dimensional QCD. Leading logarithms of $T/(gT)$ and of $gT/(g^2T)$ can be summed up using renormalization group equations.
Microstrip antennas for dual-frequency operation

Single element microstrip antenna for dual-frequency operation have been investigated. By placing shorting pins at appropriate locations in the patch, the ratio of two-band frequencies can be varied from 3 to 1.8. In many applications a smaller ratio is desired, and this can be achieved by introducing slots in the patch. In so doing, the ratio can be reduced to less than 1.3. For this type of antenna, a hybrid multiport theory is developed and theoretical results are found to be in excellent agreement with the measured.
A non-MVC EMG normalization technique for the trunk musculature: Part 2. Validation and use to predict spinal loads.

Estimates of the amount of force exerted by a muscle using electromyography (EMG) rely partially upon the accuracy of the reference point used in the normalization technique. Accurate representations of muscle activities are essential for use in EMG-driven spinal loading models. The expected maximum contraction (EMC) normalization method was evaluated to explore whether it could be used to assess individuals who are not capable of performing a maximum exertion such as a person with a low back injury. Hence, this study evaluated the utility of an EMG normalization method (Marras and Davis, A non-MVC EMG normalization technique, Part 1, method development. Journal of Electromyography and Kinesiology 2000) that draws upon sub-maximal exertions to determine the reference points needed for normalization of the muscle activities. The EMC normalization technique was compared to traditional MVC-based EMG normalization by evaluating the spinal loads for 20 subjects (10 males and 10 females) performing dynamic lifts. The spinal loads (estimated via an EMG-assisted model) for the two normalization techniques were very similar with differences being 0.9 and average error below 6%) with only the muscle gain being affected by normalization method as a result in different reference points. Based on these results, the proposed normalization technique was considered to be a viable method for EMG normalization and for use in EMG-assisted models. This technique should permit the quantitative evaluation of muscle activity for subjects unable to produce maximum exertions.
Anterior Cruciate Ligament Functional Brace Use in Sports

The routine use of functional knee braces in the anterior cruciate ligament-deficient, injured, or reconstructed knee, lacks biomechanical support. Although subjective reports favoring bracing are plentiful, objective proof of significant control of tibial translation is not. This in vivo study was designed to assess the effect of six popular braces on anterior tibial translation, isokinetic performance, and neuromuscular function in five chronically unstable anterior cruciate ligament-deficient knees. A knee stress test was performed on a specially designed device that allowed free tibial movement while monitoring anterior tibial translation and muscle function in the quadriceps, hamstring, and gastrocnemius muscles. Results show that braces can decrease anterior tibial translation between 28.8% and 39.1% without the stabilizing contractions of the hamstring, quadriceps, and gastrocnemius muscles. With lower extremity muscle activation and bracing, anterior tibial translation was decreased between 69.8% and 84.9%. Some improvement in spinal level muscle reaction times was seen with brace use, especially in the quadriceps muscle. Unfortunately, most braces appear to consistently slow hamstring muscle reaction times at the voluntary level.
Reversible Severe Combined Immunodeficiency Phenotype Secondary to a Mutation of the Proton-Coupled Folate Transporter

Hereditary folate malabsorption is a rare inborn error of metabolism due to mutations in the proton-coupled folate transporter (PCFT). Clinical presentation of PCFT deficiency may mimic severe combined immune deficiency (SCID). We report a 4-month-old female who presented with failure to thrive, normocytic anemia, Pneumocystis jirovecii pneumonia and systemic cytomegalovirus infection. Immunological evaluation revealed hypogammaglobulinemia, absent antibody responses, and lack of mitogen-induced lymphocyte proliferative responses. However, the absolute number and distribution of lymphocyte subsets, including naive T cells and recent thymic emigrants, were normal, arguing against primary SCID. Serum and cerebrospinal fluid folate levels were undetectable. A homozygous 1082-1G>A mutation of the PCFT gene was found, resulting in skipping of exon 3. Parenteral folinic acid repletion resulted in normalization of anemia, humoral and cellular immunity, and full clinical recovery. PCFT mutations should be considered in infants with SCID-like phenotype, as the immunodeficiency is reversible with parenteral folinic acid repletion.
Modeling Interface Definition Language Extensions (IDL3+) Using Domain-Specific Modeling Languages

Model-driven engineering (MDE) of distributed real-time and embedded (DRE) systems built using distributed middleware technologies typically rely on interface definition language (IDL) to define interfaces and attributes of the system under development. Recent needs for using IDL to design and implement systems composed of heterogeneous communication architectures, however, has realized the limitations of IDL. To address these limitations, vendors have proposed several non-trivial extensions to IDL also known as IDL3+. In order to leverage such extensions in the modeling domain, it is necessary to update existing tools, e.g., domain-specific modeling languages) to support such extensions. This paper provides two contributions to MDE of DRE systems using domain-specific modeling languages (DSMLs). First, this paper highlights the technical challenges associated with modeling IDL3+. Secondly, this paper discusses how to overcome such challenges in the context of a representative DSML for modeling DRE systems designed and implemented using IDL3+. Experience gained from using DSMLs to model IDL3+ shows that DSML environments as is do not suffice and need improved application frameworks to support complex DSMLs, such as IDL3+.
A versatile pseudo-random noise generator

A detailed design is presented for a digital pseudo-random noise generator. The instrument is built with standard integrated circuits. It produces both binary noise (pseudo-random binary sequence) and white Gaussian noise of variable bandwidth. By setting front panel switches to match tabulated octal codes, one may select a vast number of independent noise programs.
An Exploration Of Theoretical Foundations For Working Mothers Formal Workplace Social Networks

This paper presents a multidisciplinary integrative exploratory review of possible theoretical foundations for working mothers’ formal workplace social networks. Beginning with theoretical overviews of work-life balance, career development, mentoring, psychology, and social capital this paper develops a plausible possible framework rooted in women’s psychological developmental theory. The authors conclude that the theoretical frameworks for human resource development (HRD) and human resource management (HRM) do not identify one unified specific framework for research and scholarly investigation of working mothers’ formal workplace social networks, while presenting a conceptual model grounded in Gilligan’s (1982) principles appears to be a good fit for enhancing the understanding of the phenomenon.
Abstract 17910: Patients with Newly Diagnosed Diabetes Have Comparable Long Term Mortality with Known Diabetics After ST Segment Elevation Myocardial Infarction

Background: A significant proportion of patients presenting with ST segment elevation myocardial infarction (STEMI) have newly diagnosed diabetes mellitus (DM). Hypothesis: Our aim was to identify patients with previously undiagnosed DM and compare their outcomes to those with known DM and without DM after STEMI. Methods: Consecutive patients undergoing primary PCI for STEMI at our center between Jan 2005 - Dec 2012 were included. Routinely performed admission Glycated hemoglobin (HbA1c) was utilized to identify patients with previously undiagnosed DM (HbA1c ≥ 6.5 and no history of DM or diabetes therapy). Patients were compared for in-hospital and long-term mortality based on follow up data from our institutional PCI registry. Results: 1,734 consecutive patients underwent primary PCI for STEMI and follow up data was available for 1,566 (90%) patients. Mean age was 60 years and 67.3% were males. A quarter of the patients (24.3%, n = 382) had prior history of DM and 8% (n=95) of the remainder had undiagnosed DM. Median follow up was 35 months. Mortality was comparable in patients with known DM and newly diagnosed DM both in hospital (11.2% vs. 12.5%, p=0.87) and at long term follow up (Figure 1, 2). Mortality was significantly worse with both groups when compared with patients with no DM (In-hospital mortality 5.6%; p<0.001 for both groups). Conclusions: One in twelve patients presenting with STEMI have previously undiagnosed DM. Cardiologists have a unique opportunity for identification and initiation of diabetic therapy in this vulnerable population. Patients with newly diagnosed DM have similar short and long-term outcomes when compared with patients with a prior history of DM. ![][1] ![][2] [1]: /embed/graphic-1.gif [2]: /embed/graphic-2.gif
Formal Verification of Steady-State Errors in Unity-Feedback Control Systems

The meticulousness of steady-state error analysis of unity-feedback control systems has always been of vital significance as even a trifling glitch in this analysis may result in grievous penalties. To ensure a rigorous steady-state error analysis, this paper presents the formal verification of a generic relationship that is applicable to all kinds of inputs and types of unity-feedback control systems. This formalization builds upon the multivariate calculus theories of HOL-Light and our prior work on developing formal models of feedback control systems. To illustrate the usefulness of this result, the paper presents the formal steady-state error analysis of a Pulse Width Modulation (PWM) push-pull DC-DC converter, which is an extensively used component in various power-electronics and aerospace applications.
Behavioral Responses of Cattle to Naturally Occurring Seasonal Populations of Horn Flies (Diptera: Muscidae) Under Rangeland Conditions

The behavioral responses of cattle under the influence of naturally occurring seasonal horn fly, Haematobia irritans (L.), populations were evaluated under rangeland conditions. This study was replicated four times using 10 cows as the subsampling unit equipped with GPS collars scheduled to receive locational fixes every 5 min for 6 d prior to, and 6 d following horn fly insecticidal control application. Data derived from GPS collars were used to evaluate potential horn fly-induced behavioral modifications expressed during predawn, daytime, and nighttime periods. These data were used to analyze variables, which included distance travelled, daily area explored, vertical and horizontal head movements, and inferred activities such as resting, grazing, and walking. Horn fly populations were estimated using daily visual counts and were reduced significantly on animals following insecticidal application. There was no significant difference between treatment periods in any of the aforementioned analyzed variables. During the night-time hours estimated differences (pretreatment minus posttreatment) for distance travelled, area explored, and vertical head movements were 0.81 ± 0.46 km/d, 0.35 ± 0.21 km(2)/d, and 7.25 ± 5.30 counts/d, respectively. The implications of these observations are discussed.
Reproduction in Mealybugs

During studies of Pseudococcus gahani Green and Phenacoccus gossypii T. & Ckll., observations were made on the production of these two species of mealybugs that may be of interest to coccidologists. Schrader (1923) in his studies of Pseudococcus citri (Risso) determined that the species is nonparthenogenetic and found that the sexes occur in about equal numbers[1][1]. The data obtained on Pseudococcus gahani and on Phenacoccus gossypii show that these species also are nonparthenogenetic and have sex ratios approximating 0.5. [1]: #fn-1
Intelligent Analysis of Produce's Market Price Based on Web

Aiming at some problems,such as nonstandard product names in original data on the internet,the paper puts forward the following principles,the standardization of produce name,market and data unit;the initialization of produce categories and provinces;the choice of a material-removal strategy and data processing of a price around zero,and forms a unified and integrated price-database of produce.In order to provide comprehensive and clear analytical results for the market price of produce,the paper develops an analytical system with the help of MyEclipse enterprise workbench so as to achieve the following functions: advanced query,the analysis of price trend,the comparison of price from different provinces as well as from different markets,that of different varieties,that of chain relative and year-on-year ratio,price prediction and price monitoring,meanwhile the analytical results are shown in the form of line charts,bar charts or maps with a beautiful interface as well as a practical function.The results showed that the system could help farmers,agricultural administrations and enterprises accurately master the price variety and trend of different regions and different products.
Computational fluid dynamics modeling of the structural influences on offshore wind measurements at the Cleveland water intake crib in Lake Erie

Installation of dedicated offshore meteorological tower is very expensive due to the water depth and in some locations, icing conditions. However, many port cities have existing offshore structures such as water intake facilities or historical coastal defense structures that could be utilized as a low-cost alternative for wind resource assessment studies. Such a study was conducted using the city of Cleveland’s Water Division water intake facility located 3.5 miles offshore of downtown Cleveland in Lake Erie. Lake Erie is the smallest of the Great Lakes and as such can completely ice over during the winter. The water intake crib was installed in 1904 and has a small building on top of the water intake pipe. In 2005, a meteorological tower was installed on top of this building and has been recording wind measurements at 30, 40, and 50 m above the nominal water level. The influence of this structure on the recorded wind measurements was assessed using a computational fluid dynamics model. The assessment was...
Cirrhotic pleural effusion in the absence of ascites.

A 61-year-old female presented with a right transudative pleural effusion in the absence of ascites and other stigmata of chronic liver disease. A diagnosis of cirrhosis with a secondary hydrothorax was eventually established; however, ascites could never be demonstrated clinically or radiographically until just before her death, when hypertonic saline was administered for symptomatic hyponatremia. Based on the autopsy finding of a 1-mm hole in the right diaphragm and her clinical course, a mechanism for the production of a cirrhotic pleural effusion in the absence of ascites is proposed.
Prevalence of prone sleeping position and selected infant care practices of North Dakota infants: a comparison of whites and Native Americans.

A cross-sectional prevalence study was done in four primary care clinics (two rural and two urban sites) and four Native American clinics serving members of the Chippewa, Sioux, Hidasta, Arikara, and Mandan tribes, all in North Dakota, to determine the prevalence of prone, supine, and side sleeping position in white and Native American infants. Questionnaires for 325 infants (259 whites and 66 Native Americans) between birth and 6 months of age were completed by the infants' mothers. They reported that 69 percent of the infants slept prone, 17 percent slept supine, and 14 percent slept on their side. Native American infants, who are at 3.2 times the risk of Sudden Infant Death Syndrome compared with other North Dakota infants, slept prone 46.9 percent of the time compared with 74.4 percent of white infants (chi 2 = 23.61; 1 df; P < .0001). No differences were observed in the prevalence of the side sleeping position. Eighteen percent of the infants slept in the position reported due to advice from a physician or nurse, 8 percent of the infants slept with more than two blankets, and 5 percent slept with a pillow. Native American infants in North Dakota did not have a higher prevalence of exposure to prone sleeping position.
Future Trends in the Kinesiology Sciences

ABSTRACTKinesiology emerged from its preventative medicine and education roots to establish itself as a recognized field of inquiry with numerous sub-disciplines. This article presents four trends in modern science that will likely influence the future of kinesiology sciences. Will recent increases in greater scientific specialization be overcome by the need for greater integration and collaborative research? Will recent increases in emphasis on “greater impacts” from funded research continue? Will new kinds of review and journals replace traditional emphases on prestigious, peer-reviewed journals? Will advancements in technology increase complexity and integration of kinesiology sciences? With attention to the dangers and opportunities in these four trends, kinesiology faculty are well positioned to increase the visibility and funding of kinesiology sciences.
Microfluidic neurite guidance to study structure-function relationships in topologically complex population-based neural networks

The central nervous system is a dense, layered, 3D interconnected network of populations of neurons, and thus recapitulating that complexity for in vitro CNS models requires methods that can create defined topologically-complex neuronal networks. Several three-dimensional patterning approaches have been developed but none have demonstrated the ability to control the connections between populations of neurons. Here we report a method using AC electrokinetic forces that can guide, accelerate, slow down and push up neurites in un-modified collagen scaffolds. We present a means to create in vitro neural networks of arbitrary complexity by using such forces to create 3D intersections of primary neuronal populations that are plated in a 2D plane. We report for the first time in vitro basic brain motifs that have been previously observed in vivo and show that their functional network is highly decorrelated to their structure. This platform can provide building blocks to reproduce in vitro the complexity of neural circuits and provide a minimalistic environment to study the structure-function relationship of the brain circuitry.
Somatic and Germline Mutation of Forensic DNA Markers.

Somatic and germline mutations of forensic DNA markers DQA1, PM, STR, minisatellite DNA, and mtDNA are reviewed in this paper. DQA1 and PM are stable point substitution polymorphic loci in nuclear DNA (nucDNA); thus, somatic and germline mutations are rarely reported. STR loci somatic mutations are not found in normal cells but are very unstable in cancer cells. Germline mutations are detected in STR loci with a mutation rate of approximately 0.1%. Germline mutations of STR loci are nucleotide sequence, sex, and age dependent. Among the 13 CODIS core, TH01, TPOX, D16S539, and D3S1358 are more stable than others. Both somatic and germline mutations are found in minisatellite loci. Somatic mutations at mtDNA central region (CR) are detected in different tissues within the same individual, and the mutation rates are high in several cancer tissues. The intergenerational mutation rate of mtDNA CR is estimated to be 1/400 to 1/1200 per generation by phylogenetic analysis. The intergenerational mutation rate estimated by the recently developed pedigree method is higher, 14/1221 (1/87). This rate does not include the hot spot and heteroplasmic mutation. If substitution, heteroplasmic, and poly-C tract mutation are included, the mutation rate of mtDNA CR is 33/1590 (1/49) per generation. Proposals and practices on the interpretation of test data that may be associated with mutation are also discussed.