cssi/SciSciGPT-SciSciNet huggingface dataset:
Life Scripts and Life Stories of Oral Deaf Individuals

Cultural life scripts have been defined by research as culturally shared expectations and public knowledge of primarily positive life events that occur in sequence in an individual’s prototypical life course. In contrast, life stories are based on personal experiences and life events within one’s own life. They represent autobiographical memories that are part of episodic memory. A mixed methodology was used with two studies. First, the quantitative component investigated whether the life scripts and life stories of deaf individuals who grew up using spoken language in hearing families were similar to the life scripts and life stories of hearing individuals or culturally Deaf individuals. Then, a qualitative narrative analysis captured a more detailed description of how these individuals recalled growing up as an oral deaf person, and later being exposed to sign language and Deaf culture. Both studies highlighted the importance of communication in both positive and negative ways.
The Comparision of Theory of Human Nature of Machiavelii and Xunzi

Though Machiavelii and Xunzi belong to different area and historical background,they all took their understanding of human nature as the starting point of their political theory exploration,and in the end they established their own political theory system on the basis of human nature wicked theory.To explore their similarities and differences is benefit to better understand the political ideas of Machiavelii and Xunzi,and see clearly the spirit character between the west and the east.
The monitoring and analysis of genetically modified rice in Shenzhen market

Objective Through monitoring the background information of genetically modified rice from Shenzhen markets,to provide scientific basis for government administration,and to ensure citizens the right to know and to choose.Methods According to SN / T1204-2003,the rice samples were collected from Shenzhen markets in 2005,2006,2011 and 2012 and detected for genetically modified components.Results No genetically modified components were detected in the rice samples collected in these years,and the positive rate for GM rice is 0.Conclusion The safety is guaranteed for the genetically modified issues in rice on Shenzhen market.However,additional attentions should be paid to enhance the detection and surveillance.
Description of the Google update summarizer at TAC-2011.

In this paper we describe the system with which we have participated at TAC-2011 in the task of update summarization. This is our first participation in TAC, and we have started exploring the use of topic models for summarization. We have participated with a lightweight system that is an extension of TOPICSUM (Haghighi and Vanderwende, 2009), which we are currently extending for update summarization. The system had almost no pre-processing nor post-processing. The resulting scores rank as average across all participants. In this paper we analyze the results and outline some ideas for improvement.
Tobacco at the World Trade Organization

Tobacco control policies and comparable public health measures are increasingly being examined in the context of global trade disputes. Drawing from key World Trade Organization (WTO) disputes over public health issues, Jarman argues that the WTO is not a forum designed to assess the appropriateness and effectiveness of public health policies — it is a body created to promote free trade and protect investors and intellectual property holders. WTO arbitrators are not public health experts. Public health policies are, instead, assessed on the basis of the extent to which they conform to or break a state’s trade commitments. Jarman examines the consequences of this focus for public policymaking.
Iran and the Arab Gulf States

The Persian Gulf frames the relationship between Iran and the Arab littoral states, for through it flow vast quantities of oil upon which their economies, indeed all national economies in varying degree, depend. Yet, the relationships between Iran and its Arab neighbours during the three decades which preceded the Revolution were defined by more than just these geographical and geological realities. The interplay between Cold War and Arab politics, coupled with the Shah’s fears and ambitions, to a large extent determined their character.
Effects of experience and body weight on incubation behavior of Canada geese

L'inaptitude des femelles inexperimentees a acquerir assez de reserves pour obtenir a la fois une taille de couvee maximale et une grande assiduite au nid lors de la couvaison est une explication majeure du faible succes reproducteur des oies nidifiant pour la 1ere fois
Analytical solutions for laminar flow in membrane channels with cylindrical symmetry: Single- and dual- membrane systems

Advances in the design of membranes and membrane modules have led to a variety of new configurations with enhanced separation performance. In order to study the performance of membrane systems with novel geometries, the flow field of the continuum phase must be known. In this study an approximate approach is used to obtain the solution for steady state flow fields in several crossflow membrane filtration systems with cylindrical symmetry. The analytical solutions are presented for a single channel tubular membrane, a tubular membrane with a co-axial solid cylinder at its center, a tubular membrane located at the center of a channel with impervious walls, and a configuration with two tubular co-axial membranes. The results are compared to numerical solutions. The analytical solutions for both velocity and pressure distributions are in agreement with the results of numerical modeling.
Bronchoscopic intubation is an effective airway strategy in critically ill patients.

Abstract Purpose American Society of Anesthesiologists guidelines recommend the use of bronchoscopic intubation as a rescue technique in critically ill patients. We sought to assess the safety and efficacy of bronchoscopic intubation as an initial approach in critically ill patients. Methods We performed a retrospective cohort study of patients who underwent endotracheal intubation in the medical intensive care unit of a tertiary urban referral center over 1 academic year. The primary outcome was first-pass success rate. Measurements and main results We identified 219 patients who underwent either bronchoscopic (n = 52) or laryngoscopic guided (n = 167) intubation as the initial attempt. There was a higher first-pass success rate in the bronchoscopic intubation group than in the laryngoscopic group (96% vs 78%; P = .003). The bronchoscopic intubation group had a higher body mass index (28.4 vs 25.9; P = .027) and higher preintubation fraction of inspired oxygen requirement (0.73 ± 0.27 vs 0.63 ± 0.30; P = .044) than the laryngoscopic group. There were no cases of right mainstem intubation, esophageal intubation, or pneumothorax with bronchoscopic intubation. Rates of postintubation hypotension and hypoxemia were similar in both groups. The association with first-pass success remained with multivariate and propensity matched analysis. Conclusions Bronchoscopic intubation as an initial strategy in critically ill patients is associated with a higher first-pass success rate than laryngoscopic intubation, and is not associated with an increase in complications.
Patterns in larval reef fish distributions and assemblages, with implications for local retention in mesoscale eddies

Benthic marine populations are often replenished by a combination of larvae from local and distant sources. To promote retention of locally spawned larvae in strong, unidirectional boundary current...
Colloidal Stability of Graphene-Based Amphiphilic Janus Nanosheet Fluid

Colloidal behavior is fundamental for many applications. Methods for evaluating the stability of chemically homogeneous nanoparticles have been developed well. However, little attention has been paid to that of amphiphilic Janus nanomaterials that have recently emerged. In polar solvents, the significant influence of hydrophobic interaction complicated the evaluation of stability because of the lack of generally accepted theoretical energy potential for the interaction. To the best of our knowledge, this study is the first to investigate the colloidal stability of graphene-based amphiphilic Janus nanosheets at different salt concentrations and temperatures by developing a theoretical model with an understanding of the chemical and physical properties of the fluid. The model predictions were in good agreement with experimental stability evaluations. This study could also serve as a foundation for understanding the behavior of other amphiphilic Janus nanomaterials, achieving complex structures, and stabiliz...
Simultaneous measurement of T1/B1 and pharmacokinetic model parameters using active contrast encoding (ACE)‐MRI

The aim of this study was to assess the feasibility of combining dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) with the measurement of the radiofrequency (RF) transmit field B1 and pre-contrast longitudinal relaxation time T10 . A novel approach has been proposed to simultaneously estimate B1 and T10 from a modified DCE-MRI scan that actively encodes the washout phase of the curve with different amounts of T1 and B1 weighting using multiple flip angles and repetition times, hence referred to as active contrast encoding (ACE)-MRI. ACE-MRI aims to simultaneously measure B1 and T10 , together with contrast kinetic parameters, such as the transfer constant Ktrans , interstitial space volume fraction ve and vascular space volume fraction vp . The proposed method was tested using numerical simulations and in vivo studies with mouse models of breast cancer implanted in the flank and mammary fat pad, and glioma in the brain. In the numerical simulation study with a signal-to-noise ratio of 10, both B1 and T10 were estimated accurately with errors of 5.1 ± 3.5% and 12.3 ± 8.8% and coefficients of variation (CV) of 14.9 ± 8.6% and 15.0 ± 5.0%, respectively. Using the same ACE-MRI data, the kinetic parameters Ktrans , ve and vp were also estimated with errors of 14.2 ± 8.3% (CV = 13.5 ± 4.6%), 14.7 ± 9.9% (CV = 13.3 ± 4.5%) and 14.0 ± 9.3% (CV = 14.0 ± 4.5%), respectively. For the in vivo tumor data from 11 mice, voxel-wise comparisons between ACE-MRI and DCE-MRI methods showed that the mean differences for the five parameters were as follows: ΔKtrans = 0.006 (/min), Δve = 0.016, Δvp = 0.000, ΔB1 = -0.014 and ΔT1 = -0.085 (s), which suggests a good agreement between the two methods. When compared with separately measured B1 and T10 , and DCE-MRI estimated kinetic parameters as a reference, the mean relative errors of ACE-MRI estimation were B1 = -0.3%, T10 = -8.5%, Ktrans = 11.4%, ve = 14.5% and vp = 4.5%. This proof-of-concept study demonstrates that the proposed ACE-MRI method can be used to estimate B1 and T10 , together with contrast kinetic model parameters.
A Meeting is Not a Meeting is Not a Meeting: Implications for Teleconferencing:

The behavior of participants and the events that occurred in 48 academic, business, and government meetings were recorded using observational techniques and a participant questionnaire. Meetings we...
Neutron Transport and Activation Analysis for the IGNITEX Device

IGNITEX is a tokamak experimental device that is designed to study alpha particle heating and ignition in D-T plasmas. To make possible a small, simple, and low cost experiment, IGNITEX will employ...
Abstract 52: Enhanced Phosphodiesterase 5 (PDE5) in Thick Ascending Limbs of Dahl Salt Sensitive Rats Blunts NO-induced Inhibition of Transport

In normal rats, NO inhibits thick ascending limb (TAL) NaCl reabsorption via cGMP. In Dahl Salt Sensitive (SS) rats NO fails to decrease TAL NaCl absorption. However, the mechanism for this defect is unknown. NO stimulates soluble guanylyl cyclase to produce cGMP. The intracellular concentrations of cGMP and its effect are limited by PDE5, a cGMP-specific phosphodiesterase. We hypothesize that enhanced PDE5 expression in SS TALs blunts the inhibitory effect of NO on transport by decreasing cGMP concentration. We isolated TALs from SS and Dahl Salt-Resistant (SR) rats fed normal salt and measured PDE5 expression by Western blot. PDE5 expression was 210±20% higher in SS TALs compared to SR ( p 2 ) consumption in TALs. In SR TALs, the NO donor spermine-NONOate (NO) decreased O 2 consumption by 7.9±2.3% (p 2 consumption by 7.7±2.3% (p vs SR: 0.4±0.2 fmoles/μg, p
Towards a semantic lexicon for biological language processing: Conference Papers

This paper explores the use of the resources in the National Library of Medicine's Unified Medical Language System (UMLS) for the construction of a lexicon useful for processing texts in the field of molecular biology. A lexicon is constructed from overlapping terms in the UMLS SPECIALIST lexicon and the UMLS Metathesaurus to obtain both morphosyntactic and semantic information for terms, and the coverage of a domain corpus is assessed. Over 77p of tokens in the domain corpus are found in the constructed lexicon, validating the lexicon's coverage of the most frequent terms in the domain and indicating that the constructed lexicon is potentially an important resource for biological text processing. Copyright © 2005 John Wiley & Sons, Ltd.
Endovascular Devices for Thoracic Aortic Aneurysms

The evolution of endovascular therapy over the past two to three decades has been intimately intertwined with the introduction of new devices and technologies. While a therapeutic concept may appear applicable to treat a specific pathologic condition, without the proper tools, even a great idea may never reach clinical application. Thoracic aortic endografting for aneurysmal disease is a classic example of this situation.
Dynamic Scaling Analysis of Molecular Motion within the LAT:Grb2:SOS Protein Network on Membranes

Abstract Biochemical signaling pathways often involve proteins with multiple, modular interaction domains. Signaling activates binding sites, such as by tyrosine phosphorylation, which enables protein recruitment and growth of networked protein assemblies. Although widely observed, the physical properties of the assemblies, as well as the mechanisms by which they function, remain largely unknown. Here we examine molecular mobility within LAT:Grb2:SOS assemblies on supported membranes by single-molecule tracking. Trajectory analysis reveals a discrete temporal transition to subdiffusive motion below a characteristic timescale, indicating that the LAT:Grb2:SOS assembly has the dynamical structure of a loosely entangled polymer. Such dynamical analysis is also applicable in living cells, where it offers another dimension on the characteristics of cellular signaling assemblies.
Impact of SCBA size and firefighting work cycle on firefighter functional balance.

Abstract Slips, trips and falls are leading causes of fireground injuries. A functional balance test (FBT) was used to investigate the effects of self-contained breathing apparatus (SCBA) size and design, plus firefighting work cycle. During the FBT, subjects walked along a narrow platform and turned in defined spaces, with and without an overhead obstacle. Thirty firefighters wore three varying-sized standard SCBAs and a low-profile prototype SCBA during three simulated firefighting work/rest cycles. Firefighters were tested pre- and post-firefighting activity (one bout, two bouts with a 5-min break, or back-to-back bouts with no break). Subjects committed more errors and required longer completion times with larger SCBAs. Use of the prototype SCBA lead to lower times and fewer errors. Performing a second bout of firefighting increased completion time. Firefighters need to consider how SCBA and amount of physical activity on the fireground may influence balance in order to reduce the risk of injury.
Overcoming missed opportunities in diabetes management to improve outcomes for hospitalized patients with diabetes.

Abstract Aims The purpose of this study is to assess the impact of hospitalization on 6–12 month medication adjustment and glycemic control. Methods We conducted a retrospective cohort study of hospitalized and non-hospitalized patients with diabetes of an internal medicine residency continuity clinic. Patients had baseline and outcome HbA1c taken 6–12 months apart. Multivariate linear regression was used to model predictors of HbA1c change from baseline to outcome. Multivariate logistic regression was used to model predictors of medication adjustment between baseline and outcome clinic visits. Results Hospitalization was not a significant predictor of HbA1c change. Hospitalized patients with baseline HbA1c Discussion Our study supports previous research in that hospitalization may be seen as a “missed opportunity” to intensify treatment when indicated. Based on our findings, hospitalized patients may benefit from enhanced focus on outpatient follow-up. A next step for research is to assess efficacy of scheduling a DPV proximate to discharge for HbA1c reduction when diabetes is poorly controlled.
Tuning Performance of Spark Programs

Along with the explosive growth of data, there is a great demand to speedup the ability to process them. Although there are several platforms such as Spark that have made analysis easier to developers, the performance tuning for such platforms meanwhile becomes complex. In this paper, we propose an efficient performance optimization engine called Hedgehog to evaluate the performance based on "Law of Diminishing Marginal Utility" and give an optimal configuration setting. The initial experiments show that our optimization can gain 19.6% performance improvement compared to the naive configuration by tuning only 3 parameters.
Improved electrochemical performance of LiCoO2 electrodes for high-voltage operations by Ag thin film coating via magnetron sputtering

Increasing the operation voltage of LiCoO2 (LCO) is a direct way to enhance the energy density of the Li-ion batteries. However, at high voltages, the cycling stability degrades very fast due to the irreversible changes in the electrode structure, and formation of an unstable solid electrolyte interface layer. In this work, Ag thin film was prepared on commercial LCO cathode by using magnetron sputtering technique. Ag coated electrode enabled an improved electrochemical performance with a better cycling capability. After 100 cycles, Ag coated LCO delivers a discharge capacity of 106.3 mAh g-1 within 3 - 4.5 V at C/5, which is increased by 45 % compared to that of the uncoated LCO. Coating the electrode surface with Ag thin film also delivered an improved Coulombic efficiency, which is believed to be an indication of suppressed parasitic reactions at the electrode interface. This work may lead to new methods on surface modifications of LCO and other cathode materials to achieve high-capacity Li-ion batteries for high-voltage operations.
Reduce Before You Localize: Delta-Debugging and Spectrum-Based Fault Localization

Spectrum-based fault localization (SBFL) is one of the most popular and studied methods for automated debugging. Many formulas have been proposed to improve the accuracy of SBFL scores. Many of these improvements are either marginal or context-dependent. This paper proposes that, independent of the scoring method used, the effectiveness of spectrum-based localization can usually be dramatically improved by, when possible, delta-debugging failing test cases and basing localization only on the reduced test cases. We show that for programs and faults taken from the standard localization literature, a large case study of Mozilla's JavaScript engine using 10 real faults, and mutants of various open-source projects, localizing only after reduction often produces much better rankings for faults than localization without reduction, independent of the localization formula used, and the improvement is often even greater than that provided by changing from the worst to the best localization formula for a subject.
Selectivity control for electroreduction of ketones

The selective electrochemical conversion of ketones to value-added products still represents a challenge, due to a lack of fundamental understanding. Now, a principle has been revealed that allows the steering of the electroreduction of aliphatic ketones on platinum by carefully controlling the coordination number of the platinum atoms.
CREATING CURRICULAR CONNECTIONS: PERSPECTIVES ON DISCIPLINARY

The idea of linking the liberal arts and professional education is not new. References to its importance are prominent in the reform literature of the past several decades and the reform agendas of the 1990s (Willis 1962; Schwebel, 1985). Much of the reform discussion has examined how general education can be enhanced and professional education (especially teacher education) limited. Indeed, there are some who proffer the idea that "limited" teacher education is best defined as "no" teacher educa-
Effects of Extended Use of an Age-friendly Computer System on Assessments of Computer Proficiency, Attitudes, and Usability by Older Non--Computer Users

This study examined the impact of use of a computer software application designed specifically for older people known as PRISM—a Personal Reminder Information and Social Management system—which was installed on a computer that was placed in the homes of adults aged 65 to 98 years, who were at risk for social isolation and had minimal or no computer skills and no computers in their homes. Participants received face-to-face training on the system in their homes over several days and a variety of measures were collected at baseline and at 12 months. A growth mixture model applied to participants’ usage of the system over the course of 12 months revealed two distinct subpopulations of users—less-frequent users and more-frequent users—who after one year of exposure to the system differed in computer proficiency, attitudes toward computers, and ratings of system usability. These two groups did not differ on computer proficiency and computer attitude measures at baseline. The more-frequent user group, however, had significantly higher fluid cognitive abilities. Additional analytical models were used to further examine the relationships among the study measures. The implications of the findings are discussed in terms of the importance of usability for promoting initial engagement with a system and that increased engagement with the system can instill beliefs in these older adults that they can successfully transition to other computer-based technologies and applications. The results also underscore the importance of the user-centered design approach and designing highly usable systems for older adults with low technology proficiency.
Risk factors for anastomotic leak after esophagectomy for cancer: A NSQIP procedure-targeted analysis.

BACKGROUND Anastomotic leak is the most common major complication after esophagectomy. We investigated the 2016 American College of Surgeons National Surgical Quality Improvement Program esophagectomy targeted database to identify risk factors for anastomotic leak. METHODS Patients who underwent esophagectomy for cancer were included. Patients experiencing an anstomotic leak were identified, and univariate and multivariable logistic regression was performed to identify variables independently associated with anastomotic leak. RESULTS Of 915 patients included, 83% were male and the median age was 64 years. Patients with anastomotic leak more frequently had additional complications (87% vs 36%, P < .001). Rates of reoperation (64% vs 11%, P < .001) and mortality (8% vs 2%, P = .001) were higher in patients with anastomotic leak. After adjusting for patient and procedure characteristics, prolonged operative time (for each additional 30-minutes; adjusted odds ratios (AOR) 1.068, 95% CI, 1.022-1.115, P = .003), increased preoperative WBC count (for each 3000/µL increase; AOR 1.323, 95% CI, 1.048-1.670, P = .019), pre-existing diabetes (AOR 1.601, 95% CI, 1.012-2.534, P = .045), and perioperative transfusion (AOR 1.777, 95% CI, 1.064-2.965, P = .028) were independently associated with anastomotic leak. CONCLUSION Both patient and procedure-related factors are associated with anastomotic leak. Though frequently non-modifiable, these findings could facilitate risk stratification and early detection of anastomotic leak to reduce associated morbidity.
Augmenting Learning of Design Teamwork Using Immersive Virtual Reality

When it is done well, design teamwork is a fun, creative, and productive activity. However, the learning of effective design teamwork is hampered by lack of exposure to variation in design contexts, lack of deliberate practice and lack of appropriate feedback channels. In this chapter we present immersive Virtual Reality (VR) in accompaniment to action-reflection pedagogy as a solution to augmenting design team learning. A prospective case of using VR to augment design teamwork practice is discussed and a research agenda is outlined towards understanding VR as a medium for design teamwork, investigating its influence on design team self-efficacy and implementing it in design education courses.
A nomogram based prognostic score to predict overall survival (OS) in recurrent-metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) patients (pts) treated with immune checkpoint inhibitors (ICI)

Abstract Background ICIs are pivotal therapies in the treatment of pts with R/M HNSCC. The dismal OS of some pts underscores the need to detect pre-treatment prognostic scores. Methods Pts with R/M HNSCC receiving pembrolizumab (P) or nivolumab (N) were included in this retrospective analysis. We analyzed the impact of the following pre-treatment variables for OS using a Cox proportional hazards regression model: drug type, age, sex, tumor site, line of therapy, p-16, albumin (alb), hemoglobin (Hb), lactic dehydrogenase (LDH), lymphocyte count (LC), platelets (PLT), and neutrophil counts (NC). Results 66 pts (55%) treated with N and 55 (45%) with P were included. Characteristics: Sex: Male 100 pts (83%), female 21 pts (17%); Mean Age: 62 (SD 11); Performance Status 0-1: 63 pts (52%), 2-3: 58 pts (48%); Line of therapy, 1: 43 pts (36%), 2: 58 pts (48%), 3-4: 20 pts (16%); P-16: positive 44 pts (36%), negative 77 pts (64%); Tumor site: oropharynx 54 pts (45%), oral cavity 23 pts (19%), larynx 16 pts (13%), other 28 pts (23%); Response: complete 11 pts (9%), partial 3 pts (2%), stable disease 47 pts (39%); and disease progression: 60 pts (50%). The OS at 1 and 2 years were 52% (95% confidence interval (CI), 43%-62%) and 27% (CI 17%-42%), respectively. Age, sex, PLT, NC, LC, p-16, alb, Hb, and LDH were included in the multivariable Cox model. Adjusted hazard ratio estimates are: P-16: 0.53 (CI 0.3-0.95, P = 0.03); LC: 0.67 (CI 0.46-0.97, P = 0.03); NC: 1.25 (CI 1.01-1.56, P = 0.04); LDH: 1.67 (CI 1.01-2.78, P = 0.04); Hb: 1.69 (CI 1.00-2.87, P = 0.05); alb: 1.69 (CI 0.94-3.02, P = 0.08); PLT: 1.06 (CI 0.82, 1.37, P = 0.7); Age: 1.02 (CI 0.78-1.34, P = 0.9); and Sex: 0.98 (CI 0.5-1.91, P = 0.9). This model was used to create a nomogram based prognostic score for 1 and 2 year OS probability and median OS time. Internal model validation using bootstrapped based bias corrected estimates showed Nagelkerke’s R2 = 0.18, calibration slope of 0.67, and C-index of 0.7. Conclusions Pre-treatment LC, NC as well as LDH, Hb, alb, and p-16 had the largest impact on OS based on a prognostic nomogram. The nomogram may help treatment decisions regarding ICI use in this population. Legal entity responsible for the study The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Funding Has not received any funding. Disclosure All authors have declared no conflicts of interest.
Pegylated Interferon-Alfa-2a In Clinical Responders Often Decreases JAK2 V617F Allelic Burden and/or Reverses Clonal Hematopoiesis, but These Are Not Always Parallel In PV and ET Females

Abstract 1990 Polycythemia vera (PV) and essential thrombocythemia (ET) are hematological malignancies due to clonal proliferation arising from a multilineage stem cell. Pegylated interferon-alfa-2a is a better-tolerated form of interferon shown to be effective in inducing clinical remission and reducing the JAK2 V617F allelic burden in PV and ET patients. However, while the somatic JAK2 V617F mutation, which is seen in the majority of PV patients, is not the PV-initiating mutation, it appears to have prognostic significance. Conventional preparations of interferon alfa have been shown in isolated instances to convert clonal to polyclonal hematopoiesis in PV patients. Our study involved 6 PV patients and 3 ET patients who achieved complete clinical remission after peg-IFN-α-2a therapy. We evaluated both the allelic burden of JAK2 V617F mutation, as well as clonality of hematopoiesis by our previously developed quantitative X-chromosome-based transcriptional clonality assay. All of the PV and ET patients had variable allelic burdens of JAK2 V617F before starting the peg-IFN-α-2a therapy. The baseline allelic burden ranged from 11.8% to 93.6%, with a mean percentage of 50.9%. Peg-IFN-α-2a was administered for at least 18 months. Following peg-IFN-α-2a treatment, the allelic burden of JAK2 V617F mutation decreased in all patients, with a mean of 11.37% and a range of 2.4% -31.8% (see Table); however, clonal hematopoiesis persisted in some responding patients (see Table, these results in italics). In one ET patient (not in Table), prolonged peg-IFN-α-2a therapy induced clinical remission and resumption of polyclonal hematopoiesis, with a JAK2 V617F allelic burden of JAK2 V617F remained at In summary, pegylated interferon-alfa-2a induces clinical remission in a large proportion of PV and ET patients. However, at the cellular level, improvement in JAK2 V617F allelic burden and resumption of normal hematopoiesis are not always parallel. Disclosures: Verstovsek: Incyte Corporation: Research Funding.
Stroke prevention: An uphill battle.

Despite considerable advances to reduce the burden of stroke and other cardiovascular diseases, these remain major causes of morbidity and mortality at the population level. Guidelines have delineated contributory causes for both stroke and coronary artery disease and have identified avenues for prevention.1,2 However, in spite of the clear need to improve preventive efforts, many challenges remain for tackling the complexities of stroke prevention.3 Illustrating this concept , in this issue of Neurology ®, Boehme et al.4 report disappointing levels of primary and secondary stroke prevention in a large regional cohort of patients with stroke. Even with easy access to and coverage for health care, 80% of people diagnosed with ischemic stroke had at least 1 untreated or inadequately treated medical risk factor (e.g., hypertension, hyperlipidemia, atrial fibrillation). Fully 95% had an inadequately addressed medical risk factor or lifestyle risk factor (smoking, overweight or obesity, excess alcohol use).
Bright squeezed light reduces back-action

The use of amplitude-squeezed states of light as a probe is shown to yield superior measurements of the motion of a moving mirror at low frequencies. The demonstration offers a path to improving the sensitivity of gravitational-wave detectors.
Reevaluating ‘countermeasure from below’: evidences from judicial personnel reforms in China

In the past few years, China has made a drastic switch to a more centralized approach to institutional change, thus vastly reducing the decades-old problem of local non-compliance. Using the recent...
The Sts1 nuclear import adapter uses a non-canonical bipartite nuclear localization signal and is directly degraded by the proteasome.

The proteasome is an essential regulator of protein homeostasis. In yeast and many mammalian cells, proteasomes strongly concentrate in the nucleus. Yeast Sts1 is an essential protein linked to proteasome nuclear localization. Here we show that Sts1 contains a noncanonical bipartite nuclear localization signal (NLS) important for both nuclear localization of Sts1 itself and the proteasome. Sts1 binds the karyopherin-α import receptor (Srp1) stoichiometrically, and this requires the NLS. The NLS is essential for viability, and overexpressed Sts1 with an inactive NLS interferes with 26S proteasome import. The Sts1-Srp1 complex binds preferentially to fully assembled 26S proteasomes in vitro. Sts1 is itself a rapidly degraded 26S proteasome substrate; notably, this degradation is ubiquitin-independent in cells and in vitro and is inhibited by Srp1 binding. Mutants of Sts1 are stabilized, suggesting its degradation is tightly linked to its role in localizing proteasomes to the nucleus. We propose that Sts1 normally promotes nuclear import of fully assembled proteasomes and is directly degraded by proteasomes without prior ubiquitylation following karyopherin-α release in the nucleus.
Consumer Cooperation in Russia in the Digital Economy

Consumer cooperation continues to be an important part of the distribution infrastructure. Recently, the state has adopted programs to develop the digital economy. The aim of the paper is to study the influence of digital technologies on the further development of the organizations of the Central Union for the quality of public services. The authors present an analysis of the activities of consumer cooperation, consider the possibilities of digital technologies that can have a positive impact on the development of the Central Union system and increase the level of well-being of the rural population. The authors used abstract logical, monographic, economic, and statistical methods and came to the following conclusions: digital technologies facilitate access to various kinds of information and can assist in the development of consumer cooperation. Digital technologies are aimed at improving the daily life of a person. This is their similarity with the goals of the activities of consumer cooperation organizations. There is no clear state policy for the development of the digital economy and individual industries in Russia, therefore, inter-industry cooperation, state-cooperative, and cooperative-private partnerships are important.
Municipal Bond Trading and Political Scandals

We study municipal bond trading activity before, during, and after announcements of government officials’ misconduct. Using a sample of over 39,000,000 bond trades from January 2006 to December 2013 in nearly 500,000 bonds, we find that spreads are higher on initial news announcement, indictment announcement, and trial verdict announcement days than other trading days. Spreads remain elevated for 5 trading days following these announcements. We also find that large bond trades account for the majority of price discovery on announcement days. Overall, our results establish a link between government officials’ misconduct and municipal bond markets. TOPIC:Financial crises and financial market history Key Findings • This article examines how municipal bond traders react to news regarding potential wrongdoing by government officials. • We examine news announcements regarding the misconduct of state officials and the effect that might have on municipal bond trading. We find that when there is a news announcement related to the misconduct or wrongdoing of a government official, the average municipal bond trade size increases. • We find that municipal bond spreads increase on news related to potential miscount of state officials. • We find that price discovery in municipal bonds occurs more in larger-size trades when news related to potential miscount of state officials is revealed.
Unique Features of Prokaryotes and Their Genetics

In beginning the study of the genetics of bacteria and bacteriophages, it is important to have clearly in mind the ways in which these prokaryotes and their viruses organize their genetic processes and the ways in which these processes differ from those utilized by eukaryotic organisms. This chapter provides a brief review of important cell functions, emphasizes their unique features, and then provides an overview of the basic genetic processes to be discussed later in this book.
Assessing Functional Disability in Glaucoma: The Relative Importance of Central Versus Far Peripheral Visual Fields

Purpose To evaluate the importance of central versus far peripheral visual field (VF) loss in assessing disability in glaucoma. Methods In total, 231 patients with glaucoma or suspected glaucoma completed 24-2 VF testing and automated peripheral VFs using the suprathreshold 30- to 60-degree pattern. Questionnaires assessed fear of falling (FoF), quality of life (QOL), instrumental activities of daily living (IADLs), and driving habits; nonsedentary time, reading speed, and gait were objectively measured. Multivariable regression models analyzed the effect of central VF and/or peripheral VF damage on each outcome. Results In models including both central and peripheral VF damage (independent effects), greater central, but not peripheral, VF damage was associated with greater FoF, worse QOL, fewer daily steps, and difficulty with IADLs (P 0.5 for peripheral). For gait measures, greater peripheral, but not central, damage was associated with shorter steps and shorter strides, as well as greater variability in step length (P 0.14 for central). Model R2 values were not substantially higher (less than 5% additional explained variability) for models including both central and peripheral VF damage as compared to the best models incorporating only one region of VF damage (i.e., central or peripheral). Conclusions The relative importance of central 24 degrees versus more peripheral VF damage differs across functional domains in patients with glaucoma. Central damage is more strongly associated with most disability outcomes, although peripheral damage is more associated with specific gait measures. Studies examining the relative importance of various VF regions should assess functional domain separately and eschew integrated measures of quality of life/activity limitation.
Prevalence, predictors and trends of opioid prescribing for lower back pain in United States emergency departments.

WHAT IS KNOWN AND OBJECTIVE Current evidence-based guidelines for the treatment of acute low back pain (ALBP) recommend the use of opioid medications only after failure of nonpharmacological therapy, non-steroidal anti-inflammatory drugs and skeletal muscle relaxants and after thorough evaluation of risks and benefits. Despite this recommendation and the state of the opioid epidemic in the United States (US), opioids remain a common drug of choice for ALBP in the emergency department (ED). The purpose of this study was to quantify the prevalence and identify predictors of opioid prescribing for acute lower back pain (ALBP) in emergency departments (EDs) in the United States. METHODS This was a national, cross-sectional study of the National Hospital Ambulatory Care Survey from 2013-2016. ED visits for patients aged ≥18 years treated for ALBP were included. Patients presenting with specified reasons that an opioid may be indicated were excluded. The primary endpoint was frequency of opioids prescribed. A multivariate logistic regression model identified patient- and provider-level predictors of opioid use. RESULTS AND DISCUSSION This analysis included 2260 visits for ALBP. Opioids were prescribed in 32.3% of visits. Positive predictors of opioid prescribing were pain score of 7-10 (OR 1.85; 95% CI 1.26-2.70), and patients seen in the Southern (OR 2.53; 95% CI 1.47-4.36) or Western US (OR 2.10; 95% CI 1.19-3.70). Opioids were prescribed less often to patients who received a NSAID or acetaminophen (OR 0.38; 95% CI 0.28-0.52 and OR 0.03; 95% CI 0.01-0.10, respectively). WHAT IS NEW AND CONCLUSION Opioid prescribing rates for ALBP remain high and the predictors identified demonstrate that this prescribing pattern is not uniformly distributed across the patient and provider characteristics studied.
Creative Skepticism and Affectionate Curiosity: Scholarship, Practice, and Theory-Building in Psychoanalysis

This paper appreciates and advocates for scholarship in psychoanalysis. This is not the same as “scientific” research—running experiments, sifting through data, having a lab or control group. What ...
Risk-constrained Bi-level Optimization for Virtual Bidder Bidding Strategy in Day-Ahead Electricity Markets

Virtual bidders place virtual offers/bids into day-ahead electricity market, and the cleared energy is settled at the price difference between day-ahead market and real-time market. With high volatility in the price difference, virtual bidders face great uncertainties and financial risks in their decision making. To date, few research has been devoted to bidding strategy of virtual bidders with the consideration of its impact on market prices. Therefore, this paper proposes a risk-constrained bi-level optimization model for virtual bidders bidding strategy. In this model, uncertainties related to the other market participants offers/bids and real-time market prices are modeled through scenarios. Financial risk associated with bidding decisions is modeled using conditional value-at-risk (CVaR) metric. By virtue of Karush-Kuhn-Tucker optimality conditions, strong duality theorem and Fortuny-Amat Transformation, the proposed bi-level model is converted to a single-level mixed integer linear programming model. A case study is presented to demonstrate the effectiveness of the proposed method.
Characterization of an electrically conductive proppant for fracture diagnosticsProppant for fracture diagnostics

ABSTRACTFracture diagnosis with electromagnetic (EM) and electrical tools requires proppants with high electrical conductivity and mechanical strength. Lab measurements of the electrical and hydrau...
New Automated Activity-on-Node Calculation Grading Method for Construction Management Education Innovation

AbstractConstruction management education in the architecture, engineering, and construction (AEC) domain is increasingly challenged with managing limited resources while increasing instructors’ te...
Implementing the Universal Two-child Policy as soon as Possible Is a Win-win Policy for both the Nation and People

Based on present reality,objective existing demographic laws,and analysis on 2010 census and other recent data,we propose to start as soon as possible the preparation in 2015 and implementation of the universal two-child policy in 2016 in nationwide rural and urban areas. More specifically,we suggest that in the less developed rural areas,while universally allowing farmers to have their second child,the family planning program may encourage adequate spacing to avoid birth heaping; in the urban and more developed rural areas where late-childbearing and low fertility have become a normal social practice,the universal two-child policy should be implemented with no need to encourage birth spacing. We demonstrated that the universal two-child policy will not only satisfy people's desires for two children but also absolutely not-causing birth heaping,and it is a win-win policy for both the nation and people. As compared to the current fertility policy,the universal twochild policy is much better in some aspects of future demographic and socioeconomic conditions,and it is much more useful to strengthen the balanced socioeconomic development in China.
Failure analysis of a fuel control pressure tube from an aircraft engine

Abstract Multiple fracture cases of fuel control pressure tubes from aircraft engines have been reported. The aim of the present study is to determine the cause of this tube fracture. The studied set was composed by the mentioned tube, a welded connecting pipe, where the fracture has been produced, and a union nut. The fracture has been produced in one most critical zones of the tube, in a region next to the supporting body of the union nut to the connector. A visual examination and with a stereo microscope of the tube fracture surface has been carried out in order to determine the macrofractographic features. The results revealed a plastic macrodeformation of the tube, a damaged surface and signs of a possible corrosion process. The material has been chemical, mechanical and microstructural characterized. The results confirmed that it was within specifications. Fracture surface was also inspected by scanning electron microscopy to determine the microfractographic characteristics in order to find out the failure mechanism involved in the fracture. Fatigue striations, which are typical from a progressive fracture by a fatigue mechanism, have been observed. The origin of the fracture has been placed in defects located in the outer wall of the tube, leading to a final overload fracture.
Multi-Ion Bridged Pathway of N-Oxides to 1,3-Dipole Dilithium Oxide Complexes.

Roussi's landmark work on the generation of 1,3-dipoles from tertiary amine N-oxides has not reached its full potential since its underlying mechanism is neither well explored nor understood. Two competing mechanisms were previously proposed to explain the transformation involving either an iminium ion or a diradical intermediate. Our investigation has revealed an alternative mechanistic pathway that explains experimental results and provides significant insights to guide the creation of new N-oxide reagents beyond tertiary alkylamines for direct synthetic transformations. Truhlar's M06-2x functional and Moller-Plesset second-order perturbation theory with Dunning's [jul,aug]-cc-pv[D,T]z basis sets and discrete-continuum solvation models were employed to determine activation enthalpies and structures. During these mechanistic explorations, we discovered a unique multi-ion bridged pathway resulting from the rate-determining step, which was energetically more favorable than other alternate mechanisms. This newly proposed mechanism contains no electrophilic intermediates, strengthening the reaction potential by broadening the reagent scope and limiting the possible side reactions. This thoroughly defined general mechanism supports a more direct route for improving the use of N-oxides in generating azomethine ylide-dilithium oxide complexes with expanded functional group tolerance and breadth of chemistry.
Narcissistic admiration and rivalry and reactions to romantic breakup

Abstract This study examined how narcissism, described by the Narcissistic Admiration and Rivalry Concept (NARC), relates to reactions to romantic relationship dissolution. 246 participants completed a survey assessing the NARC components, and measures concerning a specific past relationship: Emotional reactions immediately following breakup, perceptions of the ex-partner, responsibility for initiating and attributions of blame for problems leading to breakup. Narcissistic rivalry was associated with greater externalized (anger) and internalized (sadness and anxiety) negative emotion, while narcissistic admiration was associated with greater anger and less sadness. Narcissistic admiration was associated with more positive and rivalry with more negative trait perceptions of the ex-partner. Narcissism was unrelated to attributions of blame for the breakup or relationship problems, but admiration was associated with a greater role in initiating breakup.
Recent Advances in the Management of Islet Cell Tumors

Islet cell tumors are relatively rare. They can occur as a sporadic disease and most of them have also been described as part of multiple endocrine neoplasia type 1. One of the best available estimates of frequency of the occurrence of these tumors comes from Ireland where the incidence of insulinomas is 0.9 case per million per year, gastrinomas 0.4 cases, and all other islet cell tumors less than 0.2 case per million per year.1 Islet cell tumors are usually described as slow growing and some patients with extensive metastatic disease live for many years. Nevertheless, many of these tumors release biologically active products into the circulation that can produce symptoms out of all proportion to tumor bulk. Indeed, these symptoms may be life threatening in a patient who otherwise has a relatively good prognosis from the point of view of tumor growth and spread. Conversely, the abolition of paraneoplastic symptoms can leave the patient feeling well despite the presence of a considerable tumor burden.