cssi/SciSciGPT-SciSciNet huggingface dataset:
A Robust Framework for Estimating Linguistic Alignment in Twitter Conversations

When people talk, they tend to adopt the behaviors, gestures, and language of their conversational partners. This "accommodation" to one's partners is largely automatic, but the degree to which it occurs is influenced by social factors, such as gender, relative power, and attraction. In settings where such social information is not known, this accommodation can be a useful cue for the missing information. This is especially important in web-based communication, where social dynamics are often fluid and rarely stated explicitly. But connecting accommodation and social dynamics on the web requires accurate quantification of the different amounts of accommodation being made. We focus specifically on accommodation in the form of "linguistic alignment": the amount that one person's word use is influenced by another's. Previous studies have used many measures for linguistic alignment, with no clear standard. In this paper, we lay out a set of desiderata for a linguistic alignment measure, including robustness to sparse and short messages, explicit conditionality, and consistency across linguistic features with different baseline frequencies. We propose a straightforward and flexible model-based framework for calculating linguistic alignment, with a focus on the sparse data and limited social information observed in social media. We show that this alignment measure fulfills our desiderata on simulated data. We then analyze a large corpus of Twitter data, both replicating previous results and extending them: Our measure's improved resolution reveals a previously undetectable effect of interpersonal power in Twitter interactions.
Handedness and Mortality Risk in Older Women

Left-handedness has been associated with decreased longevity, although this finding is controversial and not universal. The authors prospectively studied 39,691 women aged 55-69 years from the Iowa Women's Health Study through 5 years of mortality follow-up. No increase in mortality risk was found for left-handed women as compared with right-handed women (age-adjusted hazard ratio 1.10, 95% confidence interval (CI) 0.86-1.39) or for ambidextrous women (age-adjusted hazard ratio 1.05, 95% CI 0.73-1.49). Adjustment for body mass index, body fat distribution, smoking, and education did not alter these findings. Further analysis by cause-specific mortality (breast cancer, all other cancer, and circulatory disease) showed no relation to handedness. There was no difference in the mean age at death of left-handed, right-handed, and ambidextrous women. These findings do not support an association between left-handedness and increased mortality risk.
Road choice and quality control in the course of internationalization of Chinese universities

Having given a brief account of three models which Chinese higher education has taken in the three internationalized waves, namely, the European-American model during the establishment period, the Soviet model in the early liberation period and the marketlizational model since the reform and open to the outside world, this paper points out that in the course of internationalization Chinese higher education can adopt such models as the wholesale introduction, Chinese-foreign joint establishment and Chinese-foreign cooperation to cultivate students. Meanwhile, Chinese universities should also lay stress on quality-control, choose qualified foreign universities for cooperation and work out evaluation criteria in conform with the current international standards so as to steadily elevate the internationalized standards of Chinese universities.
Improving Event Detection with Active Learning

Event Detection (ED), one aspect of Information Extraction, involves identifying instances of specified types of events in text. Much of the research on ED has been based on the specifications of the 2005 ACE [Automatic Content Extraction] event task 1 , and the associated annotated corpus. However, as the event instances in the ACE corpus are not evenly distributed, some frequent expressions involving ACE events do not appear in the training data, adversely affecting performance. In this paper, we demonstrate the effectiveness of a Pattern Expansion technique to import frequent patterns extracted from external corpora to boost ED performance. The experimental results show that our pattern-based system with the expanded patterns can achieve 70.4% (with 1.6% absolute improvement) F-measure over the baseline, an advance over current state-of-the-art systems.
Modular, Antibody-free Time-Resolved LRET Kinase Assay Enabled by Quantum Dots and Tb(3+)-sensitizing Peptides.

Fluorescent drug screening assays are essential for tyrosine kinase inhibitor discovery. Here we demonstrate a flexible, antibody-free TR-LRET kinase assay strategy that is enabled by the combination of streptavidin-coated quantum dot (QD) acceptors and biotinylated, Tb3+ sensitizing peptide donors. By exploiting the spectral features of Tb3+ and QD, and the high binding affinity of the streptavidin-biotin interaction, we achieved multiplexed detection of kinase activity in a modular fashion without requiring additional covalent labeling of each peptide substrate. This strategy is compatible with high-throughput screening, and should be adaptable to the rapidly changing workflows and targets involved in kinase inhibitor discovery.
Neurodevelopmental models of transcription factor 4 deficiency converge on a common ion channel as a potential therapeutic target for Pitt Hopkins syndrome

The clinically pleiotropic gene, Transcription Factor 4 (TCF4), is a broadly expressed basic helix-loop-helix (bHLH) transcription factor linked to multiple neurodevelopmental disorders, including schizophrenia, 18q deletion syndrome, and Pitt Hopkins syndrome (PTHS). In vivo suppression of Tcf4 by shRNA or mutation by CRISPR/Cas9 in the developing rat prefrontal cortex resulted in attenuated action potential output. To explain this intrinsic excitability deficit, we demonstrated that haploinsufficiency of TCF4 lead to the ectopic expression of two ion channels, Scn10a and Kcnq1. These targets of TCF4 regulation were identified through molecular profiling experiments that used translating ribosome affinity purification to enrich mRNA from genetically manipulated neurons. Using a mouse model of PTHS (Tcf4+/tr), we observed a similar intrinsic excitability deficit, however the underlying mechanism appeared slightly different than our rat model - as Scn10a expression was similarly increased but Kcnq1 expression was decreased. Here, we show that the truncated TCF4 protein expressed in our PTHS mouse model binds to wild-type TCF4 protein, and we suggest the difference in Kcnq1 expression levels between these two rodent models appears to be explained by a dominant-negative function of the truncated TCF4 protein. Despite the differences in the underlying molecular mechanisms, we observed common underlying intrinsic excitability deficits that are consistent with ectopic expression of Scn10a. The converging molecular function of TCF4 across two independent rodent models indicates SCN10a is a potential therapeutic target for Pitt-Hopkins syndrome.
A new synonymy and a new species of Mydidae (Diptera) from Madagascar

Kondratieff et al. (2005) proposed a new genus of mydas fly, Hessemydas from Madagascar and included two new species, H. parkeri Kondratieff, Carr and Irwin and H. tulear Kondratieff, Carr and Irwin. Additionally, the previously described Leptomydas seyrigi Seguy, the only mydas fly previously known from the island was placed in Hessemydas. Seguy (1960) originally described this species from a single male collected at Behara. Kondratieff et al. (2005) indicated that despite numerous inquires to the Museum National d’Histoire Naturelle, Paris, France, the holotype of L. seyrigi was unavailable for examination. However, recently, through the courtesy of Christophe Daugeron, the holotype was located and made available for examination. Unfortunately, H. tulear was determined to be a junior subjective synonym of H. seyrigi. Also recently, Norman D. Penny, California Academy of Sciences made additional specimens of mydas flies available from Madagascar for determination. Among this material, a new species of Hessemydas was discovered and is described below.
Antimicrobials: Constraints on microbial warfare

Microorganisms produce antibiotics, which can exclude competitors, but bacteria typically only synthesize modest amounts of these compounds. New work suggests this may be an evolutionary strategy to balance the benefits of antimicrobial warfare against inadvertently providing help to resistant free-loaders.
Prediction of Microbial Death During Drying of a Macaroni Product

Death of Staphylococcus aureus 196E in a semolina-egg dough was studied during a variable temperature simulated drying test. Data for the death rate constant of the organism collected under steady state conditions of constant temperature and water activity were used to predict the amount of death occurring in the unsteady state test. Very good agreement was found. Utilizing the steady state information it was predicted that over 5-log cycles of kill would occur for S. aureus 196E and Salmonellae anatum NF3 during the pasta drying process. This indicates that kill caused by the process itself may not be enough if high levels of these pathogens occur initially in the dough.
Effects of Cross-Fostering on Play and Anxiety in Juvenile Fischer 344 and Lewis Rats

A cross-fostering design was used to assess the relative involvement of genetic variability and early postnatal experiences on differential levels of playfulness in juvenile Fischer 344 (F344) and Lewis (LEW) rats and the extent to which strain differences in anxiety may influence play in these two strains. F344 dams were found to lick and groom their pups less than LEW dams and this was not dependent upon the strain of the pups in the litter. As expected, F344 rats were less playful than LEW rats as demonstrated by fewer playful contacts directed to the nape of a Sprague-Dawley (SD) partner and a decreased likelihood of rotating completely to a supine position when their nape was contacted by the SD partner. These differences could not be readily explained by parallel strain differences in anxiety. The pattern of effects on play as a function of cross-fostering depended on both the genetic background of the pup and the motivational state of the pup prior to testing. Whereas in-fostered LEW pups solicited more play as isolation prior to testing increased from 4 to 24h, cross-fostered pups of both strains as well as in-fostered F344 pups were relatively insensitive to the motivational modulation of play solicitation. Responsiveness to play solicitations in pups of both strains reared by F344 dams was insensitive to prior isolation whereas pups reared by LEW dams were less likely to respond with a complete rotation to a supine position when solicited as isolation increased from 4 to 24h prior to testing. These data suggest that the overall level of playfulness in a particular strain of rat is fairly resistant to cross-fostering and may be particularly sensitive to genetic variation whereas how this urge is titrated and modified by motivational factors may be influenced more by epigenetic factors.
Dose Dependent Effect of Deferasirox on Hematopoietic Progeneitors of Myelodysplastic Syndrome

Abstract 3994 Defarasirox (DFX) is an orally available iron chelator used for management of iron overload in myelodysplastic syndrome (MDS). Given the importance of iron in generation of reactive oxygen species (ROS) and the importance of ROS in hematopoietic progenitor regulation, we sought to examine the effect of varying doses of deferasirox on CD34+ hematopoietic progenitors from MDS patients and compare to control CD34+ progenitors from human umbilical cord blood. CD34+ hematopoietic progenitors were isolated from bone marrow specimens of patients with MDS (who had below 10% bone marrow blasts) and human umbilical cord blood. The proliferation of these progenitors cultured in growth factor-containing medium with iron chelators deferasirox (5, 10 and 20 μM) or deferoxamine (DFO) 10 μM was examined on days 3, 7, and 14 of culture. Differentiation along granulocytic, monocytic and erythroid lineages was examined by flow cytometry. Apoptosis was determined by Annexin-V surface expression. Colony formation assays were performed in methylcellulose after varying periods of exposure to DFX. Total and mitochondrial ROS levels were determined by flow cytometry after exposure to DFX at varying concentrations. Progressive dose-dependent suppression of MDS progenitor proliferation in culture was observed with DFX at dose range of 5μM to 20μM [inhibition at day 14 compared to controls with DFX 5μM 4%, 10μM 60% (p Disclosures: Pullarkat: Novartis Pharma: Consultancy, Honoraria, Research Funding, Speakers Bureau. Bhatia: Novartis Pharma: Membership on an entity9s Board of Directors or advisory committees.
Primary lymphoma of the female genital tract: An analysis of 697 cases

Abstract Objective Primary lymphoma of the female genital tract (PLFGT) is a rare entity. The aim of this population-based study was to elucidate the clinico-pathological, demographic characteristics and survival of women with PLFGT. Materials and methods The Surveillance, Epidemiology, and End Results database was accessed and cases of PLFGT diagnosed between 1988 and 2012 were identified. Five-year overall (OS) and cancer-specific (CSS) survival rates were calculated with the Kaplan-Meier method. The influence of demographic and clinical parameters on survival was examined with the log-rank test. Factors independently associated with cancer-specific mortality were evaluated with a Cox proportional hazard model. Results A total of 697 women with PLFGT were identified with a median age of 54 years. The most prevalent histological subtypes were diffuse large B-cell (59.8%) and follicular (11.9%) lymphoma. Tumors were most commonly located in the ovary (37%), cervix (21.4%), and uterus (16.5%). According to the Ann Arbor staging system, 42.6% and 17.9% of cases had stage I and stage II disease, respectively. Cancer-directed surgery (CDS) was performed in the majority of cases (62.8%). Five-year OS and CSS were 70.2% and 75.2% respectively. Localized disease, premenopausal age and follicular histology were associated with superior cancer-specific mortality while CDS did not confer any mortality benefit. Conclusions This is the largest cohort of PLFGT presented in literature. While in our study surgical treatment was not associated with improved outcomes, larger multi-institutional studies should address the optimal management of women with PLFGT.
Assembly and function of bHLH–PAS complexes

The basic helix–loop–helix-PER-ARNT-SIM (bHLH–PAS) family of transcription factors coordinates the expression of distinct transcriptional programs to control processes from development to the hypoxia response and beyond. Despite differences in their target genes and modes of regulation, these transcription factors share a common domain architecture, consisting of a bHLH DNA-binding domain followed by tandem PAS domains and intrinsically disordered C-terminal regulatory domains. In PNAS, Seok et al. present the structure of the core bHLH-PAS dimer of the aryl hydrocarbon receptor (AHR)–aryl hydrocarbon nuclear receptor translocator (ARNT) transcription factor bound to DNA (1). This study provides a foundation for understanding how AHR–ARNT specifically recognizes its consensus DNA motif and highlights how changes in interdomain contacts may communicate information about ligand binding to regulate subcellular localization and transcriptional activation. The bHLH–PAS family is defined by formation of heterodimers comprising class I and class II subunits. Class I proteins are typically regulated by tissue or environmental-specific factors, whereas class II proteins are expressed ubiquitously. Examples of class I proteins include AHR (regulated by xenobiotics), hypoxia-inducible factor-α (HIF-α, regulated by hypoxia), neuronal PAS domain proteins (NPAS, developmentally regulated), and circadian locomotor output cycles protein kaput (CLOCK, circadian rhythms). ARNT is the predominant class II subunit found in bHLH–PAS complexes, whereas the related protein brain and muscle ARNT-like 1 (BMAL1) appears to be primarily dedicated to CLOCK to regulate circadian rhythms. Although cellular studies have largely outlined the different regulatory mechanisms that control heterodimerization, subcellular localization, and activity of these complexes, the structural basis for their assembly and diverse functions … [↵][1]1To whom correspondence should be addressed. Email: cpartch{at}ucsc.edu. [1]: #xref-corresp-1-1
On the use of climate covariates in aquatic species distribution models: are we at risk of throwing out the baby with the bath water?

Species distribution models (SDMs) in river ecosystems can incorporate climate information by using air temperature and precipitation as surrogate measures of instream conditions or by using independent models of water temperature and hydrology to link climate to instream habitat. The latter approach is preferable but constrained by the logistical burden of developing water temperature and hydrology models. We therefore assessed whether regional scale, freshwater SDM predictions are fundamentally different when climate data versus instream temperature and hydrology are used as covariates. Maximum Entropy (MaxEnt) SDMs were built for 15 freshwater fishes using one of two covariate sets: (1) air temperature and precipitation (climate variables) in combination with physical habitat variables; or (2) water temperature, hydrology (instream variables) and physical habitat. Three procedures were then used to compare results from climate vs. instream models. First, equivalence tests assessed average pairwise differences (site-specific comparisons throughout each species' range) among climate and instream models. Second, ‘congruence’ tests determined how often the same stream segments were assigned high habitat suitability by climate and instream models. Third, Schoener's D and Warren's I niche overlap statistics quantified range-wide similarity in predicted habitat suitability from climate vs. instream models. Equivalence tests revealed small, pairwise differences in habitat suitability between climate and instream models (mean pairwise differences in MaxEnt raw scores for all species < 3×10-4). Congruence tests showed a strong tendency for climate and instream models to predict high habitat suitability at the same stream segments (median congruence = 68%). D and I statistics reflected a high margin of overlap among climate and instream models (median D = 0.78, median I = 0.96). Overall, we found little support for the hypothesis that SDM predictions are fundamentally different when climate versus instream covariates are used to model fish species' distributions at the scale of the Columbia Basin. This article is protected by copyright. All rights reserved.
Evidence that C9ORF72 Dipeptide Repeat Proteins Associate with U2 snRNP to Cause Mis-splicing in ALS/FTD Patients

Hexanucleotide repeat expansion in the C9ORF72 gene results in production of dipeptide repeat (DPR) proteins that may disrupt pre-mRNA splicing in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients. At present, the mechanisms underlying this mis-splicing are not understood. Here, we show that addition of proline-arginine (PR) and glycine-arginine (GR) toxic DPR peptides to nuclear extracts blocks spliceosome assembly and splicing, but not other types of RNA processing. Proteomic and biochemical analyses identified the U2 small nuclear ribonucleoprotein particle (snRNP) as a major interactor of PR and GR peptides. In addition, U2 snRNP, but not other splicing factors, mislocalizes from the nucleus to the cytoplasm both in C9ORF72 patient induced pluripotent stem cell (iPSC)-derived motor neurons and in HeLa cells treated with the toxic peptides. Bioinformatic studies support a specific role for U2-snRNP-dependent mis-splicing in C9ORF72 patient brains. Together, our data indicate that DPR-mediated dysfunction of U2 snRNP could account for as much as ∼44% of the mis-spliced cassette exons in C9ORF72 patient brains.
The Projectilic Image: Islamic State’s Digital Visual Warfare and Global Networked Affect

Islamic State’s (IS) image-warfare presents an auspicious opportunity to grasp the growing role of digital images in emerging configurations of global conflict. To understand IS’ image-warfare, this article explores the central role of digital images in the group’s war spectacle and identifies a key modality of this new kind of warfare: global networked affect. To this end, the analysis focuses on three primary sources: two Arabic-language IS books, Management of Savagery (2004) and O’ Media Worker, You Are a Mujahid!, 2nd Edition (2016), and a video, Healing the Believers’ Chests (2015), featuring the spectacular burning of a Jordanian air force pilot captured by IS. It uses the method of ‘iconology’ within a case-study approach. I analyze IS’ doctrine of image-warfare explained in the two books and, in turn, examine how this doctrine is executed in IS video production, conceptualizing digital video as a specific permutation of moving digital images uniquely able to enact, and via repetition, to maintain...
Sexual risk behaviors in African American and Puerto Rican women: Impulsivity and self-control

Abstract Millions of people are living with the human immunodeficiency virus (HIV). African American and Hispanic/Latino communities suffer the most severe burden of HIV in the US. The ultimate goal of this study was to better understand risk factors for this infection: Do impulsivity and self control operate independently or synergistically with respect to HIV sexual risk behaviors in women? An enhanced understanding of these risk factors may better inform future interventions. Among the total of 343 female participants, half were African American and the other half were Latina. Data in this study were collected in the area of New York City during 2014–2016, when the mean age of the participants was 39 years. Linear regression analyses were used to examine the associations of impulsivity and self control with HIV sexual risk behaviors. Impulsivity and self control were independently associated with most of the HIV sexual risk behaviors examined. In addition, the interaction terms between impulsivity and low self control were all significantly associated with each of the sexual risk behaviors. Prevention programs should consider incorporating the roles of impulsivity and self control simultaneously as related to HIV risk behaviors.
The Airflow Field Around An Operating Tire and Its Effect on Tire Power Loss

The airflow direction, velocity, and turbulence level were measured aroung the left front tire of a passenger car operating on-road over the normal driving speed range. Both photographic and hot-wire anemometer techniques were employed. The measured airflow field, and other idealized ones, were used to select appropriate values for the tire heat transfer coefficient from previous GMR work. Tire power loss was then calculated with the GMR Combined Thermo-Mechanical Model to assess the importance of the airflow field on tire power loss. It was found that for the range of realistic flow conditios, tire power loss could be changed by up to 6% by the flow conditions alone.
Differential Diagnosis of Pancreatic and Biliary Duct Diseases

Diseases affecting the biliary and pancreatic duct systems can be organized by radiographic appearance and location of the lesions. This presentation will use such a pattern approach to facilitate effective differential diagnosis. The present chapter will review the processes causing abnormalities of the pancreatic and biliary duct systems and will establish a differential diagnostic framework for the accurate interpretation of cholangiography, pancreatography, and other imaging tests.
American cancer society guidelines- are we truly improving all aspects of effectiveness?: American cancer society guidelines for screening and surveillance for early detection of colorectal polyps and cancer: Update 1997

Abstract This paper reports revised American Cancer Society guidelines for colorectal cancer screening and surveillance. Compared with the last revision in 1992, the current recommendations expand options for average risk screening to include colonoscopy and double contrast barium enema. The guideline introduces a concept called “total colon evaluation,” which appears to imply equivalency of colonoscopy and double contrast barium enema. Recommendations for high risk groups follow widely accepted protocols, but the postpolypectomy recommendations include unconventional features such as returning patients with a single, small tubular adenoma to general population screening after a negative follow-up colonoscopy.
Exploiting Advances in Video Analytics to Support Military Operations and Related Applications

As the prime contractor for the U.S. Army's Persistent Surveillance and Dissemination System of Systems (PSDS2) program, we have witnessed firsthand the U.S. military's video glut problem. Established in 2005 to address an urgent requirement for a video processing, exploitation, and dissemination (PED) capability, the PSDS2 program has provided the core video dissemination backbone used by the U.S. Central Command (CENTCOM) in Iraq and by the International Security Assistance Force (ISAF) in Afghanistan, where it is still in active use. PSDS2 integrates realtime sensor data from multiple sensor types-including hundreds of video sensors-and makes it available on-demand simultaneously to thousands of users both in near real time and streamed from forensic archives. Given the large number of stationary and mobile video and other sensors that are being integrated, the criticality of the services provided, and the austerity-in terms of available communications bandwidth, equipment size, weight, power, cost and cooling (SWaP+C2) limitations, and military personnel availability-we are motivated to investigate the use of analytics to address the video glut problem.
Low order equivalent system identification for the Tu-144LL supersonic transport aircraft

Low order equivalent system models were identified from flight test data for the Tu-144LL supersonic transport aircraft. Flight test maneuvers were executed by Russian and American test Pilots flying the aircraft from Zhukovsky airfield outside Moscow, Russia. Flight tests included longitudinal and lateral / directional maneuvers at supersonic cruise flight conditions. Piloted frequency sweeps and multi-step maneuvers were used to generate data for closed loop low order equivalent system modeling. Model parameters were estimated using a flexible. high accuracy Fourier transform and an equation error / output error (EE/OE) formulation in the frequency domain. Results were compared to parameter estimates obtained using spectral estimation and subsequent least squares fit to frequency response data in Bode plots. Modeling results from the two methods agreed well for both a frequency sweep and multiple concatenated multi-step maneuvers. For a single multi-step maneuvers the EE/OE method gave a better model fit with improved prediction capability. A summary of closed loop low order equivalent system identification results for the Tu-144LL, including estimated parameters, standard errors, and flying qualities level predictions, were computed and tabulated.
Expanded Algorithm and Updated Experience with Breast Reconstruction Using a Staged Nipple-Sparing Mastectomy following Mastopexy or Reduction Mammaplasty in the Large or Ptotic Breast

Background:Staged nipple-sparing mastectomy following mastopexy or reduction mammaplasty was first described in 2011 by Spear et al. to expand the indications for nipple-sparing mastectomy to women with large or ptotic breasts. Since that time, the authors have revised their treatment algorithm and
Different Types of Pain

Pain can be classified based on the pathophysiological mechanism, duration, anatomic location and the presence of malignancy. Each classification is important and understanding those classifications and their definitions is crucial to guide diagnosis and management.
Lost in reading: The predicament of postcolonial writing in Kamel Daoud’s The Meursault Investigation

Kamel Daoud’s novel The Meursault Investigation (first published in Algeria in 2013 as Meursault, contre-enquete) has sparked controversy. In 2014 it won awards in France and was nominated for the ...
Maternal risk factors and neonatal outcomes in placental abruption among patients with equal access to health care.

Placental abruption complicates 1% of pregnancies, and is associated with significant morbidity and mortality. The objective was to examine risk factors and outcomes in pregnancies complicated by a...
Adolescent Attention to Disgust Visuals in Cigarette Graphic Warning Labels.

Abstract Purpose Adolescents are often a target audience for disgust-eliciting antismoking messages, including graphic warning labels (GWLs) on cigarette packages. Yet, few studies have examined how adolescents attend and respond to disgust imagery frequently depicted in these messages. Methods A within-subjects eye-tracking experiment with middle school youth (N = 436) examined attention for GWLs that feature disgust versus nondisgust images. Hypotheses were based on emotion theory and previous findings with adult participants. This study also tested whether living with a smoker moderated effects of attention on negative emotions and risk beliefs. Results Participants paid similar levels of attention to warnings with disgust visuals as they did warnings with nondisgust visuals, accounting for other differences in the warnings. The presence of a disgust visual drew greater attention to the warning image and reduced attention for the warning text. These viewing patterns were similar for youth who live with a smoker and those who do not. Attention to disgust imagery was the only attentional factor to predict negative emotional reactions, and this relationship was driven by results observed among youth who live with a smoker. Attention to neither image nor text predicted risk beliefs. Conclusions GWLs with disgust imagery do not trigger more or less attention to the overall warnings but do influence allocation of attention to images over text. Future work should confirm whether attention to disgust imagery itself is important for triggering negative emotional responses, particularly with youth for whom the message is more personally relevant.
Time Series Methodology in STORJ Token Prediction

The STORJ token has gained a lot of attention from consumers, businesses, investors and open security software communities due to its decentralized nature and return payment ideology. Things become even more complicated if the data has high volatility. While there has been significant research done to analyze the network topology of these kinds of cryptocurrencies, limited work has been performed to analyze the efficacy of different time series models on the overall price prediction. In our work, an extensive study on linear models as well as hybrid models and temporal convolutional neural networks have been done based on different uncertainty quantification measures to show how different models perform in capturing the underlying volatility and overall price prediction.
Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures through a PKC-Dependent Mechanism

The marine natural product bryostatin 1 has demonstrated procognitive and antidepressant effects in animals and has been entered into human clinical trials for treating Alzheimer's disease (AD). The ability of bryostatin 1 to enhance learning and memory has largely been attributed to its effects on the structure and function of hippocampal neurons. However, relatively little is known about how bryostatin 1 influences the morphology of cortical neurons, key cells that also support learning and memory processes and are negatively impacted in AD. Here, we use a combination of carefully designed chemical probes and pharmacological inhibitors to establish that bryostatin 1 increases cortical synaptogenesis while decreasing dendritic spine density in a protein kinase C (PKC)-dependent manner. The effects of bryostatin 1 on cortical neurons are distinct from those induced by neural plasticity-promoting psychoplastogens such as ketamine. Compounds capable of increasing synaptic density with concomitant loss of immature dendritic spines may represent a unique pharmacological strategy for enhancing memory by improving signal-to-noise ratio in the central nervous system.
In Vivo Characterization of the Swine Airway Morphometry and Motion Based on Computed Tomographic Imaging During Respiration.

Swine are a commonly used model in translational pulmonary research. However, in vivo airway morphometry during respiration has not been studied in extensive detail using modern imaging tools. Chest computed tomographic was performed in swine (n = 3) at multiple stages of respiration. Morphometric parameters of each airway segment at end-expiration and end-inspiration were compared as well as among matched anatomical regions (proximal and distal; ventral, lateral, and dorsal). Analysis included segment diameter, length, ellipticity, and the bifurcation angle between daughter branches. Deformation of the airway during respiration was qualitatively visualized using a point-to-point deformation map. Comparison of airway generation showed airway diameter and length were larger at end-inspiration in the fourth and seventh generations compared to end-expiration. Bifurcation angle was larger at end-inspiration compared to end-expiration. Analysis by anatomical region showed that length and bifurcation angle were larger at inspiration in the distal airway regions only. Regardless of respiratory phase, the lateral regions had larger diameters and lengths compared to the ventral and dorsal regions at similar generations and proximal regions had larger bifurcation angles. The findings that morphological changes were more prevalent in distal airways during respiration was confirmed by analysis of a deformation map. Compared to human airway models, the relative diameter may be smaller and length may be greater in swine in similar airway generations. This morphometric description of the swine airways during respiration may guide conduct of preclinical translational studies, revealing advantages and limitations of swine models for specific evaluations. Such morphometric parameters may directly determine the suitability of the swine model for the study of lung interventions, in terms of recapitulation of human morphometry dynamics.
MARX, RAÇA E NEOLIBERALISMO

A perspectiva Marxista pode ser util para a compreensao dos conceitos de raca e racismo na medida em que propoe uma percepcao dialetica do capitalismo, enquanto uma totalidade social, que inclui os modos de producao, relacoes de producao e o conjunto pragmaticamente em evolucao das instituicoes e ideologias que facilitam e impulsionam a sua reproducao.
The case for a qualitative lesion assessment system for coronary angiography.

Since the advent of coronary angiography, the standard for reporting of coronary lesion severity has been to utilize percent diameter stenosis (%DS). Given the imperfections of %DS as well as the widespread availability of intraprocedural intracoronary imaging and physiology assessment, it is time to consider a simpler yet more clinically relevant lesion assessment system. We compiled ten actual cases and presented these cases to 10 operators, providing 100 independent lesion assessments. For each case, operators were asked to describe lesions using %DS and a simplified lesion assessment system. We assessed the relationship between %DS and qualitative lesion assessment as well as the relationship of both measurements to the chosen plan. Greater variability exists with %DS than with qualitative lesion assessment. Despite this, there is good correlation between %DS and the qualitative lesion assessment (ρ = 0.8221). There remains overlap of lesion assessment using the qualitative lesion assessment tool suggesting that even with this simpler tool, there remains interobserver variability (ICC = 0.5164, 95% confidence interval [CI] 0.2924-0.7955). When assessing how both lesion assessment, there appears to be a stronger correlation between the qualitative lesion assessment and the chosen plan versus the %DS and the chosen plan (ρ = 0.9069 vs ρ = 0.8001, P < .01). Given the superior performance of the proposed qualitative system and the ability to estimate lesion severity using both anatomic and clinical factors, we feel that professional societies and clinicians should begin to embrace this simplified means of lesion assessment.
Neurodevelopmental Disorders Commonly Presenting with Sleep Disturbances

There are multiple disorders of neurodevelopment that present with co-occurring sleep disturbances. Many of these neurodevelopmental disorders (NDD) include sleep disturbances in their diagnostic criteria. Neurobiological, genetic, and environmental factors overlap to cause different sleep disorders in individuals with NDD. Caregivers often present reporting either insomnia or hypersomnia, and based on the clinical history and findings from diagnostic tests, an appropriate diagnosis can be made. It is crucial that clinicians understand the different presentations of sleep disturbances in individuals with NDD.
Critical Success Factors in Collaborative R&D Projects

The concept of Critical Success Factors (CSFs) in projects represents an area of scholarly activity with roots going back over some 40 years. Critical Success Factors are generally defined as elements of a project which, when addressed by project stakeholders, increase the likelihood of success; these are the independent variables that make success more likely. This chapter will examine the nature of two critical elements in R&D project management: (1) the nature of project success and (2) project scritical success factors. Addressing the current scholarship on success and CSFs, we will examine how these concepts form a critical knowledge base for translating the planning and organisation of R&D project activities into projects with a greater likelihood for successful outcomes. The chapter will investigate the multiple perspectives necessary to accurately gauge project success (focusing on the critical measurement questions of ‘What’ and ‘When’). We will offer some examples from a case study of Google Glass and conclude with some prescriptive advice for both scholars and practitioners.
Ethical Obligations to Provide Novelty

TikTok is a popular platform that enables users to see tailored content feeds, particularly short videos with novel content. In recent years, TikTok has been criticized at times for presenting users with overly homogenous feeds, thereby reducing the diversity of content with which each user engages. In this paper, we consider whether TikTok has an ethical obligation to employ a novelty bias in its content recommendation engine. We explicate the principal morally relevant values and interests of key stakeholders, and observe that key empirical questions must be answered before a precise recommendation can be provided. We argue that TikTok's own values and interests mean that its actions should be largely driven by the values and interests of its users and creators. Unlike some other content platforms, TikTok's ethical obligations are not at odds with the values of its users, and so whether it is obligated to include a novelty bias depends on what will actually advance its users' interests.
'You've Got Your Crook, I've Got Mine': Why the Disqualification Clause Doesn't (Always) Disqualify

Alcee Hastings was impeached, convicted, and removed from the federal bench. He later ran for Congress, won, and was seated without controversy. But what if the Senate had instead imposed the ultimate political death sentence for a federal officer: "disqualification to hold and enjoy any Office of honor, Trust or Profit under the United States"? Had Hastings been impeached, convicted, AND disqualified, would he still have been able to take his seat in the House? Should he have been able to do so? Yes. This Article argues that, for reasons of history, structure, and institutional practice, the Disqualification Clause should not be read to apply to legislative seats. While an impeached, convicted, and disqualified President, department head, or judge may be disqualified from ever again serving in the executive or judicial branches, he cannot be barred from serving in the House or the Senate after his voters have knowingly pardoned him.
NETI@home: A Distributed Approach to Collecting End-to-End Network Performance Measurements

NETI@home is an open-source software package that collects network performance statistics from end-systems. It has been written for and tested on the Windows, Solaris, and Linux operating systems, with testing for other operating systems to be completed soon. NETI@home is designed to run on end-user machines and collects various statistics about Internet performance. These statistics are then sent to a server at the Georgia Institute of Technology, where they are collected and made publicly available. This tool gives researchers much needed data on the end-to-end performance of the Internet, as measured by end-users. Our basic approach is to sniff packets sent from and received by the host and infer performance metrics based on these observed packets. NETI@home users are able to select a privacy level that determines what types of data are gathered, and what is not reported. NETI@home is designed to be an unobtrusive software system that runs quietly in the background with little or no intervention by the user, and using few resources.
Single‐site monthly streamflow simulation using entropy theory

[1] Using entropy theory, a new method for single-site monthly streamflow simulation is developed, which is capable of preserving mean, standard deviation, skewness, and lag-one correlation. The method entails deriving joint and conditional probability density functions using the entropy theory, determining the Lagrange multipliers using the information obtained from the historical record, and then simulating streamflow by sequential sampling from the conditional distribution. The advantage of the entropy-based method is that it does not make any assumptions about the probability distribution of the streamflow data. It can also preserve the cross-correlation between streamflow of the last month of the previous year and the first month of the current year and avoid the generation of negative values. The method can also be extended to incorporate higher-order moments and more lag correlations if needed. The disadvantage is that the method will be cumbersome when more statistics need to be preserved and the bimodality that may exist in the empirical probability density function cannot yet be resolved. Application to the Colorado River basin shows that the entropy-based method satisfactorily simulates monthly streamflow.
Ca2(+)-dependent interactions between the C-helix of troponin-C and troponin-I. Photocross-linking and fluorescence studies using a recombinant troponin-C.

We have used in vitro mutagenesis to synthesize in Escherichia coli a recombinant rabbit skeletal troponin-C (designated as TnC57) in which Cys-98 was replaced with leucine, and Ala-57 in the C-helix of the N-terminal domain was replaced with cysteine. TnC57 labeled with the bifunctional photocross-linker benzophenone-4-maleimide could be photocross-linked with troponin-I in both the binary complex with troponin-I and in the ternary complex with troponin-I and troponin-T. The fluorescence lifetime of TnC57 labeled with the probe N-iodoacetyl-N'-(5-sulfo-1-naphthyl)ethylenediamine decreased from 13.2 +/- 0.1 to 11.8 +/- 0.1 ns when Ca2+ bound to the low affinity triggering sites. Complexation with either troponin-I or both troponin-I and troponin-T resulted in significant increases in this lifetime both in the absence and the presence of Ca2+. In either the binary or the ternary complex, this lifetime increased from 15.5 to 18.0 ns upon Ca2+ binding to the low affinity sites. Complementary acrylamide-quenching studies yielded results that are consistent with the fluorescence lifetime results. Our results show that the C-helix of troponin-C interacts with troponin-I, in confirmation of recent zero-length cross-linking results (Leszyk, J., Grabarek, Z., Gergely, J., and Collins, J.H. (1990) Biochemistry 29, 299-304). Moreover, they are in support of a model (Herzberg, O., Moult, J., and James, M.N.G. (1986) J. Biol. Chem. 261, 2638-2644) in which the binding of Ca2+ to the triggering sites in the N-terminal domain of troponin-C results in the movement of the B- and C-helices away from the central helix, thereby exposing a putative hydrophobic binding site for troponin-I.
Evaluating a Legal Argument Progra: The BankXX Experiments

In this article we evaluate the BankXX program from several perspectives. BankXX is a case-based legal argument program that retrieves cases and other legal knowledge pertinent to a legal argument through a combination of heuristic search and knowledge-based indexing. The program is described in detail in a companion article in (this issue of) the Journal of Artificial Intelligence and Law. Three perspectives are used to evaluate BankXX: (1) classical information retrieval measures of precision and recall applied against a hand-coded baseline; (2) knowledge- representation and case-based reasoning perspectives, where the baseline is provided by the functionality of a well-known case-based argument program, HYPO [Ashley, 1990]; and (3) search perspective, in which the performance of BankXX run with various parameter settings, for instance, resource limits, is compared. In this article we report on an extensive series of experiments performed to evaluate the program. We also describe two brief experiments on ancillary questions regarding the program''s search behavior and knowledge representation. Finally we offer some general conclusions that might be drawn from these particular experiments.
Low-voltage metal-fuse technology featuring a 1.6V-programmable 1T1R bit cell with an integrated 1V charge pump in 22nm tri-gate process

This work introduces the first high-volume manufacturable metal-fuse technology in a 22nm tri-gate high-k metal-gate CMOS process. A high-density array featuring a 16.4µm2 1T1R bit cell is presented that delivers a record low program voltage of 1.6V. This low-voltage operability allows the array to be coupled with logic-voltage power delivery circuits. A charge pump voltage doubler operating on a 1V voltage rail is demonstrated in this paper with healthy fusing yield.
Two-dimensional infrared detector arrays

An introduction to overall IR array concepts and particular array designs is presented, and examples of laboratory and observational data obtained with IR arrays are given. Hybrid array designs, extrinsic silicon accumulation-mode charge injection devices, and switched-FET or switched-sample photoconductor techniques are summarized. Three recent astronomical observation projects which used IR arrays are examined.