cssi/SciSciGPT-SciSciNet huggingface dataset:
ETTIN (ARF3) physically interacts with KANADI proteins to form a functional complex essential for integument development and polarity determination in Arabidopsis

KANADI (KAN) transcription factors promote abaxial cell fate throughout plant development and are required for organ formation during embryo, leaf, carpel and ovule development. ABERRANT TESTA SHAPE (ATS, or KAN4) is necessary during ovule development to maintain the boundary between the two ovule integuments and to promote inner integument growth. Yeast two-hybrid assays identified ETTIN (ETT, or AUXIN RESPONSE FACTOR 3) as a transcription factor that could physically interact with ATS. ATS and ETT were shown to physically interact in vivo in transiently transformed tobacco epidermal cells using bimolecular fluorescence complementation. ATS and ETT were found to share an overlapping expression pattern during Arabidopsis ovule development and loss of either gene resulted in congenital fusion of the integuments and altered seed morphology. We hypothesize that in wild-type ovules a physical interaction between ATS and ETT allows these proteins to act in concert to define the boundary between integument primordia. We further show protein-protein interaction in yeast between ETT and KAN1, a paralog of ATS. Thus, a direct physical association between ETT and KAN proteins underpins their previously described common role in polarity establishment and organogenesis. We propose that ETT-KAN protein complex(es) constitute part of an auxin-dependent regulatory module that plays a conserved role in a variety of developmental contexts.
A Longitudinal Investigation of the Impact of Customization-Related Service Attributes on Customer Satisfaction and Profitability

In this era of increasing competition and financial crunch, service organizations are facing great pressure of cutting operating cost. Downsizing service employees is a widely used coping strategy. At service attribute level, a direct effect of downsizing is the reduced performance of the service attributes that are dependent on service personnel. However it is unknown whether this is a sustainable strategy, as current literature provides competing explanations about the effects of service attributes on customer satisfaction and no work has been done to directly investigate the effect on profitability. Using 24 quarters of archival customer satisfaction data and financial data from 25 SBUs in a large healthcare organization, this study aims to empirically examine the long-term impact of service attributes on customer satisfaction and profitability. Our initial findings indicate that although under-investing does bring immediate cost benefits, it generated mixed impact on a SBU's long term customer satisfaction and profitability.
Effect of Pressure on Arsenic Diffusion in Germanium

We report preliminary results of a study of the activation volume for diffusion of arsenic in germanium. High-temperature high-pressure anneals were performed in a liquid argon pressure medium in a diamond anvil cell capable of reaching 5 GPa and 750° C, which is externally heated for uniform and repeatable temperature profiles. The broadening of an ion-implanted arsenic profile was measured by Secondary Ion Mass Spectrometry. Hydrostatic pressure retards the diffusivity at 575° C, characterized by an activation volume that is +15% of the atomic volume of Ge. Implications for diffusion mechanisms are discussed.
Study of affine image warping on a linear processing array

Several methods for parallel affine image warping on a linear processor array are considered. The methods were implemented on the Carnegie Mellon Warp machine and the Carnegie Mellon-Intel Corporation iWarp computer (treated as a linear array), and performance figures are provided. Both systolic methods, which feed one of the images in a stream, and non-systolic methods, which partition both images, are treated. A scanline method that combines some of the features of both, but which requires a fast transposed method is also described. The authors articulate three characteristics that affect the design of parallel image warping algorithms: affine warping is easily invertible, the mapping is known at the start of execution, and nearby input pixels map to nearby output pixels. The authors conclude that non-systolic methods give slightly better execution time and are easier to programs than systolic methods but require much larger processor memories. >
Comment on Brines and Fiorentine

In this comment, the author commends Julie Brines for her contribution to our understanding that housework is about more than getting the housework done. In Brines's words, it is about doing gender, especially the importance of the symbolic display of gender norms, which she seems to assume is equally important to both women and men. The commentator suggests that other dimensions, such as the exchange of nurturing services, may be more important than symbolic display. She urges Brines to consider how much agency women have in the situation and not assume that displaying gender symbolically is either their choice or what they think they are actually doing. In her review of Robert Fiorentine, the commentator challenges the primacy he gives cultural and psychological explanations of the continued sex segregation of the labor market. She argues that structural barriers are likely more salient and that strong enforcement of existing laws would help bring those barriers down and reduce the sex segregation obser...
The Problem of Psychosocial Distress and the Crisis in Psychology

This paper proposed a new model of psychosocial stress in the light of changing social norms and value orientation. It is argued that the prevalent psychosocial distress underscores the emergence of psycbopathy in everyday life. In today's world, psychopathy is becoming a norm and is sustained by social and political institutions. The article discusses the consequent crisis of psychology in Russia and the United States. A need to develop a unifying science with less rigid professional and disciplinary boundaries is highlighted
Epidemiologic analysis of gene-environment interaction in twins.

Our aim was to develop a simple method for testing gene-environment interaction in twin data ascertained through affected twins (probands), with known exposure status of both cotwins. To this end we derived formulae for two epidemiologic measures, as a function of prevalence of an exposure and genotype, and disease risk conditional on exposure and genotype: (1) relative risk of disease in exposed vs. unexposed cotwins, stratified by zygosity and proband exposure status (RRE), and (2) relative risk of disease in MZ vs. DZ cotwins, stratified by exposure status of proband and cotwin (RRZ). Then we investigated the behavior of these two measures under different assumptions about the relations between exposure and genotype in terms of their effect on disease risk. If an exposure has a different effect in the presence vs. absence of the genotype, RRE differs between MZ and DZ cotwins. Similarly, if a genotype has a different effect in exposed vs. unexposed persons, RRZ differs between exposed and unexposed cotwins. However, large differences in RRE between MZ and DZ cotwins, or large differences in RRZ between exposed and unexposed cotwins, do not occur except under very extreme conditions, such as a genotype that increases disease risk in exposed individuals, and has a protective effect in unexposed individuals. These results suggest that power to detect gene-environment interaction is limited with this approach. Conversely, if large differences in RRE or RRZ are observed, they are likely to reflect strong gene-environment interaction. © 1994 Wiley-Liss, Inc.
Bioavailability of cerium oxide nanoparticles to Raphanus sativus L. in two soils.

Cerium oxide nanoparticles (CeO2 NP) are a common component of many commercial products. Due to the general concerns over the potential toxicity of engineered nanoparticles (ENPs), the phytotoxicity and in planta accumulation of CeO2 NPs have been broadly investigated. However, most previous studies were conducted in hydroponic systems and with grain crops. For a few studies performed with soil grown plants, the impact of soil properties on the fate and transport of CeO2 NPs was generally ignored even though numerous previous studies indicate that soil properties play a critical role in the fate and transport of environmental pollutants. The objectives of this study were to evaluate the soil fractionation and bioavailability of CeO2 NPs to Raphanus sativus L (radish) in two soil types. Our results showed that the silty loam contained slightly higher exchangeable fraction (F1) of cerium element than did loamy sand soil, but significantly lower reducible (F2) and oxidizable (F3) fractions as CeO2 NPs concentration increased. CeO2 NPs associated with silicate minerals or the residue fraction (F4) dominated in both soils. The cerium concentration in radish storage root showed linear correlation with the sum of the first three fractions (r2 = 0.98 and 0.78 for loamy sand and silty loam respectively). However, the cerium content in radish shoots only exhibited strong correlations with F1 (r2 = 0.97 and 0.89 for loamy sand and silty loam respectively). Overall, the results demonstrated that soil properties are important factors governing the distribution of CeO2 NPs in soil and subsequent bioavailability to plants.
Financial Incentives to Raise Productivity

The Delphi method is used to explore the feasibility of financial incentive programs for the construction labor force in the U.S. The most appropriate methods for measuring on-site performance, the likely effects of different financial incentive programs, and the ways to enhace their effectiveness are explored. The Delphi panel of experts included 37 specialists of various interrelated professions. The study comprised three rounds of questionnaires of which two included feedback of results. The findings indicate that financial incentive programs for the construction labor force are not only feasible, but they could materially raise productivity, lower production costs, shorten construction time, improve the quality of management, and increase the earnings of the workers.
Influence of durable mechanical circulatory support and allosensitization on mortality after heart transplantation

Background Allosensitization has been shown to negatively affect post-heart transplant (HTx) survival even with a negative crossmatch. Whether allosensitization related to mechanical circulatory support (MCS) is associated with worse post-HTx survival remains controversial. Methods Adult HTx recipients listed in the United Network for Organ Sharing database (July 2006–December 2012) were identified. Multivariate Cox regression assessed the effect of allosensitization on survival. Propensity matching was performed to compare patients who were and were not allosensitized. Kaplan-Meier survival analysis compared matched and unmatched patients in the MCS and medically managed cohorts. Results We identified 11,840 HTx recipients, of whom 4,167 had MCS. MCS was associated with allosensitization in multivariate logistic regression. Each different MCS device was associated with worse post-HTx survival in multivariate Cox regression. Allosensitization did not predict post-HTx mortality in MCS patients (hazard ratio, 1.07; 95% confidence interval, 0.89–1.28; p = 0.48. Among patients without MCS, allosensitization was associated with post-HTx mortality (hazard ratio, 1.19; 95% confidence interval, 1.03–1.39; p = 0.02). Kaplan-Meier analysis revealed equivalent survival in unmatched and matched cohorts when MCS patients who were allosensitized were compared with non-allosensitized MCS patients. Among non-MCS patients, allosensitization was associated with worse survival in unmatched and matched analysis. Conclusions MCS was associated with allosensitization. For MCS patients, allosensitization did not independently predict worse post-HTx outcome. Among non-MCS patients, allosensitization was associated with worse post-HTx survival. Allosensitization appears to be a heterogeneous process influenced by presence of MCS.
Sweating the Small Stuff: The Cost of Immaterial Tax Law Provisions

The United States federal income tax law has been the subject of decades of study due to its burgeoning level of detail and complexity, including many calls to scrap the income tax and replace it with new approaches, such as a consumption tax. This Article argues that a more manageable and pragmatic approach to improving the tax law, itself a creature of incrementalism, is to reverse its complexity through an incrementalist approach. The tax code contains many immaterial provisions, including two provisions applicable to millions of individuals (the $100 floor on personal casualty and theft deductions, and the up-to-$250 deduction for educators). Such provisions have trivial budget implications and negligible, if any, incentive effects on taxpayer behavior. These provisions add unnecessary complexity and thus inflate transaction costs for the government and taxpayer. For the immaterial provisions residing within tax expenditures, such as the educator deduction, an institutional economics analysis reveals such tax expenditures are ideal candidates for removal from the tax code, to instead be directly expended by the government. The Article offers recommendations as to how to identify and eliminate tax law clutter.
Leaf Temperature Affects Resistance to the Banks Grass Mite (Acari: Tetranychidae) on Drought-Resistant Grain Sorghum

Field and greenhouse experiments were perfonned to screen sorghum lines for antibiosis to the Banks grass mite, Oligonychus pratensis (Banks), and to detennine if a relationship exists between different types of drought resistance and antibiosis to the Banks grass mite. We also tested the hypothesis that Banks grass mite development and population growth during drought stress is slower on drought-resistant than on drought-susceptible sorghum lines because lower leaf temperatures are usually maintained on the fonner. Banks grass mite development time in degree days, fecundity, and leaf area coverage were measured on sorghum lines previously classified as either prehowering drought-resistant, postHowering drought-resistant, overall drought-resistant, or drought-susceptible. Per- and post-Howering, drought-resistant lines were the most resistant to Banks grass mite population growth under dryland conditions with moderate postHowering drought stress. Banks grass mite development time depended on leaf temperature and was also different among lines, suggesting that leaf temperatures varied among lines. Likewise, fecundity was affected by temperature, but after the temperature differences were taken into account, fecundity was not significantly different among lines. Under dryland conditions with moderate postHowering drought stress, the leaf area covered by mite colonies was lower on pre- and postHowering, drought-resistant lines than on drought-susceptible lines but not different between overall drought-resistant lines and drought-susceptible lines. Under irrigated conditions, the leaf area covered by mite colonies was not different among lines. These results suggest that pre- and postHowering drought-resistant lines maintained relatively lower leaf temperatures in dryland plots but not irrigated plots during Banks grass mite colonization. Besides the leaf temperature effect, antibiosis also was associated with drought resistance. When leaf temperatures were similar, more degree days were needed for Banks grass mites to complete development on postHowering, drought-resistant lines than on drought-susceptible lines. However, leaf temperature appeared to be the most important factor affecting Banks grass mite developmental time and population growth. Host plant resistance based on leaf temperature may suppress spider mite outbreaks more effectively over time than host plant resistance based on plantderived allelochemicals because of reduced selection pressure.
PHYTOPHTHORA PALMIVORA: A COMPARATIVE STUDY OF "TYPICAL" AND "ATYPICAL" ISOLATES FROM CACAO (THEOBROMA CACAO)

SUMMARY Sixteen isolates of Phytophthora from cacao in 10 countries were compared for cultural, morphological, physiological, and biochemical characters. Twelve isolates were "typical" of P. palmivora and four were "atypical." The typical isolates had a characteristic stellate pattern on carrot agar while the atypical isolates produced profuse aerial mycelium with no distinct pattern. Elongate, caducous sporangia tapering to the base, with long pedicels attached to the often flat bases were formed by the atypical isolates in contrast to the ovoid, caducous sporangia with short pedicels attached to the round bases produced by the typical isolates. Chlamydospores were formed by the typical but not the atypical isolates. The atypical isolates grew at 9 C on semisynthetic agar medium whereas the typical isolates did not. Two types of electrophoretic protein-band patterns were detected among the 16 isolates; one type was common to the atypical isolates and the other to the typical isolates. The typical isolates correspond to Morphological Form 1 of P. palmivora and the atypical isolates to Morphological Form 4. The atypical group of isolates may represent a species distinct from P. palmivora.
Impact of right ventricular size and function on survival following transcatheter aortic valve replacement

Abstract Background The impact of pre-procedural RV size and function on outcomes following transcatheter aortic valve replacement (TAVR) is not well established. The aim of this study was to investigate the role of right ventricular size and function on outcomes following TAVR. Methods and results Between November 2008 and June 2013, 268 consecutive patients (age 80.5±7.9years, aortic valve area 0.79±0.16cm 2 ) with symptomatic severe aortic stenosis (AS) undergoing TAVR at Mayo Clinic were included. Transthoracic echocardiographic quantitative and semiquantitative assessment of RV chamber size and systolic function was performed and included tricuspid annular plane systolic excursion (TAPSE), RV systolic excursion velocity (S′), fractional area change (FAC), RV index of myocardial performance (RIMP). The primary endpoint of all-cause mortality after TAVR was measured and observed in 65 patients (median follow up duration: 412days). Univariate analysis identified semiquantitative RV dilatation (p Conclusion RV dilatation is an important determinant of postoperative outcomes in patients undergoing TAVR.
Speech writing for library conferences

Une analyse lexicale du vocabulaire specialise employe par les bibliothecaires lors des reunions professionnelles est presentee. Une liste des occurences les plus frequentes (noms, expressions, sigles) est dressee. De meme, le syntaxe-type (structure, duree) d'une intervention est decodee
Calcium-Activated Potassium Channels in Presynaptic Nerve Terminals

In their classical study of excitability in squid axons, Hodgkin and Huxley (cf. Hodgkin, 1967) showed that the nerve action potential could be explained by selective, transient sodium (Na) and potassium (K) conductance changes that were explicitly described by sets of voltage- and time-dependent parameters. Subsequent work on a wide variety of excitable cells has revealed that, in contrast to Na conductances, a number of K conductances do not conform to the simple voltage- and time-dependent mechanism that occurs in squid axons. For example, in many types of cells, some K conductances are activated by a rise in the calcium (Ca) activity in the cytoplasm (cf. Meech, 1978). Also, in some cells, K conductances may be modulated by intracellular cyclic nucleo- tides, for example, as a consequence of neurotransmitter action (Castelluci et al., 1980; De Peyer et al., 1982). Klein and Kandel (1980) have demonstrated that inactivation of a specific K conductance, due to transmitter action on presynaptic neurons in Aplvsia. may have profound behavioral effects. In addition, it has been suggested that the complex schizophrenia-like syndrome elicited by phencyclidine intoxication in man and animals may involve block of a specific class of presynaptic K channels in the central nervous system (CNS) (Albuquerque et al., 1981; Bartschat and Blaustein, 1984c).
The Survival of Salmonella typhimurium in Propylene Glycol/Water Mixtures.

The effect of propylene glycol, a coolant used in dairy processing plants, on the growth and survival of Salmonella typhimurium was studied. Cultures were inoculated into 0.1% reconstituted nonfat dry milk with glycol concentrations ranging from 0 to 50% (Aw 0.99-0.83) and were incubated at 37°C or -1°C. Serial dilutions were plated on tryptic soy agar (Difco), incubated at 37°C for 24 h and enumerated. At 37°C, 5% or more glycol inhibited the growth of S. typhimurium . At concentrations >20% glycol, Aw<0.96, no recovery was possible after 4 h at 37°C. At -1°C, a slow decline in population was seen regardless of glycol concentration. The higher the concentration, the faster the rate of decline in population. Aeration of the system resulted in a more rapid decrease in the number of S. typhimurium than the static system.
Structured decision making as a framework for large‐scale wildlife harvest management decisions

Fish and wildlife harvest management at large spatial scales often involves making complex decisions with multiple objectives and difficult tradeoffs, population demographics that vary spatially, competing stakeholder values, and uncertainties that might affect management decisions. Structured decision making (SDM) provides a formal decision analytic framework for evaluating difficult decisions by breaking decisions into component parts and separating the values of stakeholders from the scientific evaluation of management actions and uncertainty. The result is a rigorous, transparent, and values-driven process. This decision-aiding process provides the decision maker with a more complete understanding of the problem and the effects of potential management actions on stakeholder values, as well as how key uncertainties can affect the decision. We use a case study to illustrate how SDM can be used as a decision-aiding tool for management decision making at large scales. We evaluated alternative white-tailed deer (Odocoileus virginianus) buck-harvest regulations in New York designed to reduce harvest of yearling bucks, taking into consideration the values of the state wildlife agency responsible for managing deer, as well as deer hunters. We incorporated tradeoffs about social, ecological, and economic management concerns throughout the state. Based on the outcomes of predictive models, expert elicitation, and hunter surveys, the SDM process identified management alternatives that optimized competing objectives. The SDM process provided biologists and managers insight about aspects of the buck-harvest decision that helped them adopt a management strategy most compatible with diverse hunter values and management concerns.
An Initial Assessment of Secular Trends in Muscular Strength Among Children, Adolescents, and Adults Across the Lifespan: National Sample of Americans.

Purpose:Adequate muscular strength has important implications for morbidity and early mortality prevention. There are no data on the recent trends in muscular strength across lifespan, which was this study’s purpose.Design:Cross-sectional.Setting:2011 to 2012 and 2013 to 2014 waves of the National Health and Nutrition Examination Survey across the United States.Participants:The analyzed sample included 12 295 participants aged 6 to 85 years.Measures:Muscular strength was assessed via a handgrip dynamometer.Analysis:Adjusted Wald test.Results:As expected, men (vs women) had greater grip strength, with grip strength declining as age increased. Central to the focus of this study, there were no changes in absolute or relative grip strength across the waves for any of the evaluated populations (considering age, gender, and race–ethnicity).Conclusion:These findings demonstrate that muscular grip strength, across all age, gender, and race–ethnicity populations in the United States, has not changed in the 2 succe...
Synthesis, Structures, and CO Release Capacity of a Family of Water-Soluble PhotoCORMs: Assessment of the Biocompatibility and Their Phototoxicity toward Human Breast Cancer Cells.

Two manganese(I) carbonyl complexes derived from 2-(pyridyl)benzothiazole (pbt) and 1,10-phenanthroline (phen) release carbon monoxide (CO) under low-power broad-band visible-light illumination. CO photorelease from [Mn(CO)3(pbt)(PTA)]CF3SO3 (1, where PTA = 1,3,5-triaza-7-phosphaadamantane) is accompanied by an emergence of a strong fluorescence around 400 nm from almost nonfluorescent preirradiated 1. However, [Mn(CO)3(phen)(PTA)]CF3SO3 (2) showed no such phenomenon upon prolonged illumination under similar experimental conditions. The two analogous rhenium(I) complexes, namely, [Re(CO)3(pbt)(PTA)]CF3SO3 (3) and [Re(CO)3(phen)(PTA)]CF3SO3 (4), have also been synthesized and characterized to compare their photo properties with the manganese congeners. Complexes 3 and 4 exhibit moderate CO release upon irradiation with low-power UV light. All four complexes are highly soluble in anaerobic/aerobic aqueous media and are also considerably more stable when kept under dark conditions. The inherently luminescent...
Landslides as Polycausal Phenomena

According to Burton, Kates and White, (1978) the impact of natural hazards is a function of the benefits associated with living in a risk zone minus the costs of damage and of adjustment to the hazard. Alternatively, UNDRO (1982) argued that the sum total of risk is a product of the magnitude and extensiveness of the natural hazard impact, the number and size of elements at risk, and their vulnerability in terms of probable levels of damage and destruction.
Captopril but not mononitrate or intravenous magnesium reduced short-term mortality after suspected myocardial infarction

Source Citation ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group. ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous m...
Taxonomic Index to Volumes 21 Through 30

Listed below are all biologic names to be found in the third ten volumes of this journal. Included are all primary references, such as systematic discussions, illustrations, and diagrams.
Gut microbiota's effect on mental health: The gut-brain axis.

The bidirectional communication between the central nervous system and gut microbiota, referred to as the gut-brain-axis, has been of significant interest in recent years. Increasing evidence has associated gut microbiota to both gastrointestinal and extragastrointestinal diseases. Dysbiosis and inflammation of the gut have been linked to causing several mental illnesses including anxiety and depression, which are prevalent in society today. Probiotics have the ability to restore normal microbial balance, and therefore have a potential role in the treatment and prevention of anxiety and depression. This review aims to discuss the development of the gut microbiota, the linkage of dysbiosis to anxiety and depression, and possible applications of probiotics to reduce symptoms.
The Atomic Scale Electrochemical Lithiation and Delithiation Process of Silicon

While silicon (Si) has tenfold capacity of commercially used graphite, its application is still limited due to its limited cyclability. In this in situ X-ray reflectivity study, a detailed mechanistic model of the first two (de)lithiation processes of a silicon wafer is presented, which sheds light onto the fundamental difference of the reaction of Li ions with crystalline and amorphous materials. Furthermore, this study provides insight into the formation and further evolution of the inorganic solid electrolyte interphase (SEI) layer on Si anodes. The results show that the lithiation of crystalline Si is a layer-by-layer, reaction limited two-phase process, but the delithiation of LixSi (resulting in amorphous Si) and the lithiation of amorphous Si are reaction-limited single-phase processes. Furthermore, the thickness-density product of the inorganic SEI layer increases during lithiation and decreases during delithiation, resembling a “breathing” behavior; the inorganic SEI layer thickness varies between 40 and 70 A. Additionally, a low-electron-density “Li-dip” layer is found between the SEI and lithiated Si during the delithiation process, suggesting kinetically limited ion transport within the SEI, which is speculated to be one of the origins of battery's internal resistance. Several implications of the findings on battery performance in general are discussed.
Nonintegrating Human Somatic Cell Reprogramming Methods.

Traditional biomedical research and preclinical studies frequently rely on animal models and repeatedly draw on a relatively small set of human cell lines, such as HeLa, HEK293, HepG2, HL60, and PANC1 cells. However, animal models often fail to reproduce important clinical phenotypes and conventional cell lines only represent a small number of cell types or diseases, have very limited ethnic/genetic diversity, and either senesce quickly or carry potentially confounding immortalizing mutations. In recent years, human pluripotent stem cells have attracted a lot of attention, in part because these cells promise more precise modeling of human diseases. Expectations are also high that pluripotent stem cell technologies can deliver cell-based therapeutics for the cure of a wide range of degenerative and other diseases. This review focuses on episomal and Sendai viral reprogramming modalities, which are the most popular methods for generating transgene-free human induced pluripotent stem cells (hiPSCs) from easily accessible cell sources.
New Theoretical Aspects in DIET

A number of stimulated desorption issues that have been addressed in terms of wave packet propagation over image-potential augmented, intermediate state potential curves will be discussed. Specifically, giant enhancements in ESD yields of 0(a)/Pd(111) and laser-induced desorption for N0/Pt(lll) will be considered.
Commentary on genetic testing of children: maintaining an open future.

Abstract Pediatric nurses have the opportunity to facilitate genetic testing decisions made by parents on behalf og their children. When facilitating and evaluating the genetic testing decision, the pediatric nurse should consider whether the decision is in the best interest of the child and protects the child's right to an open future. Pediatric nurses should take advantage of the various formal and informal educational genetic and ethics resources available.
Multi-scale membrane reactor (MR) modeling and simulation for the water gas shift reaction

Abstract This work focuses on the multi-scale modeling of a high-pressure membrane reactor (MR) carrying out the water gas shift reaction (WGSR). The work assesses the MR’s effectiveness in transforming coal-derived syngas into two streams, one rich in hydrogen and the other rich in carbon dioxide. The model employs Reynolds Transport Theorem derived constitutive equations at the reactor and the catalyst pellet scales. Convection/conduction/reaction/diffusion phenomena are accounted for, using the Ergun, Chapman-Enskog, Stefan-Maxwell, and Dusty-Gas models, respectively. The model’s power and flexibility are demonstrated by carrying out numerical simulations for both the MR and packed-bed reactors (PBR) for various operating conditions and design parameters. It is shown that significant variation of the catalyst pellet effectiveness factor occurs along the reactors’ axial direction, and that catalyst pellets of the same diameter exhibit different effectiveness factors within the PBR and MR environments. The effect of the catalyst solid’s thermal conductivity on the temperature gradients within the catalytic pellet, and the effect of the sweeping gas’ pressure/temperature on the MR’s behavior are both quantified. Adiabatic and wall-isothermal operations are examined and are shown to exhibit significant differences from each other for both reactors.
Optimal Sampling of BRDF's of Varying Complexity

The goal of this paper is to develop a sampling grid with a minimum number of measurements to interpolate a reflectance function, $R(\theta, \varphi)$ , of a maximum complexity to within a desired error bound. Our approach is: (i) Specify a correlation function over the angles representing the complexity of $R(\theta, \varphi)$ , (ii) use this correlation function to perform Gaussian process regression on a given sampling grid to determine the variance of the estimated function, and (iii) find the optimal sampling grid by adjusting the parameters of the experimental design to minimize the computed variance of the regression. The optimal sampling grid or, equivalently, uniform sampling grid is a significant improvement over the commonly used equal-angle sampling grid as being able to reduce number of sampling points by 30% for the same accuracy while reducing data acquisition and processing time.
Field Test of a Dialectical Behavior Therapy Skills Training-Based Intervention for Smoking Cessation and Opioid Relapse Prevention in Methadone Treatment

Objective: Almost all individuals in methadone treatment for opioid dependence smoke cigarettes, and half of people in methadone treatment have an opioid relapse within six months. Dialectical beha...
Optimal Substrate-Trapping Mutants to Discover Substrates of HDAC1.

Histone deacetylase 1 (HDAC1) regulates transcription by deacetylating histones. In addition to histones, several non-histone proteins are HDAC1 substrates, which suggests a role for HDAC1 beyond epigenetics. Unfortunately, the identification of non-histone substrates has been largely serendipitous, which makes full characterization of HDAC1 functions difficult. To overcome this challenge, inactive "trapping" mutants were recently developed to identify HDAC1 substrates. To optimize substrate trapping, the relative trapping abilities of 17 inactive HDAC1 mutants was assessed. HDAC1 H141A, F150A, and C151A showed strong binding to substrates LSD1 and p53. Interestingly, each mutant preferentially trapped a different substrate. By combining several inactive mutants, the trapping strategy will facilitate the discovery of new HDAC1 substrates and shed light on the variety of HDAC1-related functions in cell biology.
Exposed! (Part 1)

This case discusses the pharmacokinetic interaction between buspirone and rifampin, leading to decreased anti-anxiety effect of buspirone. Buspirone is a cytochrome P450 3A4 substrate and rifampin is a 3A4 inducer.
Etiologic aspects of cold agglutinin disease: evidence for cytogenetically defined clones of lymphoid cells and the demonstration that an anti-Pr cold autoantibody is derived from a chromosomally aberrant B cell clone

This study investigated the clonal nature of cold agglutinin disease in a series of nine patients, which included the benign or idiopathic form as well as cases with an underlying lymphoma. Surface marker phenotyping and karyotypic analysis were performed on peripheral blood lymphocytes. An increased proportion of B cells was found in four cases and in three of these patients a monoclonal B cell population was identified with a mu, kappa phenotype. In the same three cases, as well as an additional patient, an aberrant karyotype was demonstrated. The cytogenetic abnormality present in all four cases included trisomy 3; two patients also had a trisomy 12. One of these four patients had a well-differentiated lymphoma and underwent a splenectomy. Splenic lymphocytes were transformed with Epstein-Barr virus and cultured en masse. Eight clones were established producing the same cold agglutinin with identical specificity as that present in the patient's plasma. Five of these clones were studied cytogenetically, and all had the same abnormal karyotype (51,XX,+3,+9,+12,+13,+18) found in peripheral blood and splenic lymphocytes. Thus, in this case, the cold reactive autoantibody was produced by the chromosomally abnormal, neoplastic clone of lymphocytes. Our findings support the view that cold agglutinin disease represents a spectrum of clonal disorders.
Trends in Concomitant Meniscal Surgery Among Pediatric Patients Undergoing ACL Reconstruction: An Analysis of ABOS Part II Candidates From 2000 to 2016

Background:Rates of anterior cruciate ligament (ACL) reconstruction among pediatric and adolescent patients are increasing. Limited knowledge exists about population-level rates of concomitant meni...
R2-P2 rapid-robotic phosphoproteomics enables multidimensional cell signaling studies.

Recent developments in proteomics have enabled signaling studies where > 10,000 phosphosites can be routinely identified and quantified. Yet, current analyses are limited in throughput, reproducibility, and robustness, hampering experiments that involve multiple perturbations, such as those needed to map kinase-substrate relationships, capture pathway crosstalks, and network inference analysis. To address these challenges, we introduce rapid-robotic phosphoproteomics (R2-P2), an end-to-end automated method that uses magnetic particles to process protein extracts to deliver mass spectrometry-ready phosphopeptides. R2-P2 is rapid, robust, versatile, and high-throughput. To showcase the method, we applied it, in combination with data-independent acquisition mass spectrometry, to study signaling dynamics in the mitogen-activated protein kinase (MAPK) pathway in yeast. Our results reveal broad and specific signaling events along the mating, the high-osmolarity glycerol, and the invasive growth branches of the MAPK pathway, with robust phosphorylation of downstream regulatory proteins and transcription factors. Our method facilitates large-scale signaling studies involving hundreds of perturbations opening the door to systems-level studies aiming to capture signaling complexity.
ELECTROCARDIOGRAPHIC CHARACTERISTICS IN A LARGE COHORT OF ACUTE PULMONARY EMBOLISM

Electrocardiographic (ECG) findings in acute pulmonary embolism (PE) were historically described in small cohorts or in suspected, but not confirmed, acute PE. We describe ECG findings amongst consecutive patients with imaging-confirmed acute PE in a retrospective cohort at a large, multi-hospital
Genres of Rewriting in Second Temple Judaism: Scribal Composition and Transmission

In this book, Molly Zahn investigates how early Jewish scribes rewrote their authoritative traditions in the course of transmitting them, from minor edits in the course of copying to whole new compositions based on prior works. Scholars have detected evidence for rewriting in a wide variety of textual contexts, but Zahn's is the first book to map manuscripts and translations of biblical books, so-called 'parabiblical' compositions, and the sectarian literature from Qumran in relation to one another. She introduces a new, adaptable set of terms for talking about rewriting, using the idea of genre as a tool to compare and contrast different cases. Although rewriting has generally been understood as a vehicle for biblical interpretation, Zahn moves beyond that framework to demonstrate that rewriting was a pervasive textual strategy in the Second Temple period. Her book contributes to a powerful new model of early Jewish textuality, illuminating the rich and diverse culture out of which both rabbinic Judaism and early Christianity eventually emerged.
Positive youth development in the context of household member contact with the criminal justice system

Abstract This study addresses recent calls for investigations of within-group variability and resilience among youth with justice-involved family members by examining the nature and correlates of positive youth development (PYD) among adolescents who have experienced the arrest of a household member. Using data from the Mobile Youth Survey, a community-based study of risk and resilience among predominantly African American and low-income youth, we use linear mixed models to examine how individual, family, and community factors contribute to positive youth development and to identify associations between PYD and indicators of internalizing symptoms and delinquent behaviors. Results suggest that maternal warmth, parental monitoring, participation in religious activities, sense of belonging at school, and neighborhood connectedness were positively associated with PYD. Results further suggest that positive youth development is inversely associated with internalizing symptoms and delinquency. Findings underscore the importance of adopting a positive youth development lens in research on adolescents with justice-involved family members and suggest the value of developing interventions that not only reduce problems but that also capitalize on and foster youth assets.
Study of corneal best fitted shapes of normal eyes in young adults

Objective To analysis and judge corneal best fitted shape of normal eyes in young adults.Methods Sixty normal eyes of thirty youths were selected by randomly,Corneal surface heights of aconic fitted shape(FA),ellipse fitted shape(FE),sphere fitted shape(FS) and spherocylinder fitted shape(FSC) were acquired to calculate corneal surface aberration by OrbscanIIz system and ocular aberration by Zywave System.The correlations were analyzed by linear regression.Results (1)Corneal aberration 0f FA with(0.0653±0.8503)μm had a positive linear correlation with ocular aberration(0.8640±0.1424)μm (P=O.000) and a negative linear correlation with ocular high order aberration(0.6840±0.0688)μm(P=0.015).(2)Corneal aberration of FE with -(0.0492±0.3818)μm had a negative linear correlation with ocular aberration and ocular high order aberration (P=0.001).(3)Corneal aberration of FS with(0.0770±1.2517)μm and FSC with(0.1134±1.2247)μm had a negative linear correlation with ocular high order aberration(P=0.001).Conclusions Corneal surface elevation and aberration varied by corneal fitted shapes in the same cornea,Aconic fitted shape and ellipse fitted shape ofnormal eyes in young adults were close to the best fitted shape. Key words: Corneal Fitted Shape; Corneal Best Fitted Shape; Corneal Aberration; Ocular Aberration
Physical and magnetic properties of Ba(Fe 1 − x Mn x ) 2 As 2 single crystals

Single crystals of $\text{Ba}{({\text{Fe}}_{1\ensuremath{-}x}{\text{Ru}}_{x})}_{2}{\text{As}}_{2}$, $xl0.37$, have been grown and characterized by structural, magnetic, and transport measurements. These measurements show that the structural/magnetic phase transition found in pure ${\text{BaFe}}_{2}{\text{As}}_{2}$ at 134 K is suppressed monotonically by Ru doping but, unlike doping with $TM=\text{Co}$, Ni, Cu, Rh, or Pd, the coupled transition seen in the parent compound does not detectably split into two separate ones. Superconductivity is stabilized at low temperatures for $xg0.2$ and continues through the highest doping levels we report. The superconducting region is domelike, with maximum ${T}_{c}(\ensuremath{\sim}16.5\text{ }\text{K})$ found around $x\ensuremath{\sim}0.29$. A phase diagram of temperature versus doping, based on electrical transport and magnetization measurements, has been constructed and compared to those of the $\text{Ba}{({\text{Fe}}_{1\ensuremath{-}x}T{M}_{x})}_{2}{\text{As}}_{2}$ ($TM=\text{Co}$, Ni, Rh, and Pd) series as well as to the temperature-pressure phase diagram for pure ${\text{BaFe}}_{2}{\text{As}}_{2}$. Suppression of the structural/magnetic phase transition as well as the appearance of superconductivity is much more gradual in Ru doping, as compared to Co, Ni, Rh, and Pd doping, and appears to have more in common with ${\text{BaFe}}_{2}{\text{As}}_{2}$ tuned with pressure; by plotting ${T}_{S}/{T}_{m}$ and ${T}_{c}$ as a function of changes in unit-cell dimensions, we find that changes in the $c/a$ ratio, rather than changes in $c$, $a$, or $V$, unify the $T(p)$ and $T(x)$ phase diagrams for ${\text{BaFe}}_{2}{\text{As}}_{2}$ and $\text{Ba}{({\text{Fe}}_{1\ensuremath{-}x}{\text{Ru}}_{x})}_{2}{\text{As}}_{2}$, respectively.
On the taxonomic status of the varieties of Chorizanthe angustifolia (Polygonaceae)

Chorizanthe angustifolia var. eastwoodiae was named by Goodman in 1934, but has since generally been ignored as a taxon. A limited number of C. angustifolia var. angustifolia collections available for comparison and lack of clearly defined characters differentiating the two varieties likely account for the taxonomic concept for C. angustifolia that rejects infraspecific taxa. Nevertheless, several characters previously unnoted in floristic literature distinguish var. angustifolia from var. eastwoodiae. Variety angustifolia is a yellow-green plant with straw-colored tepals that are narrow and long-pointed, and has 3 stamens per flower. Variety eastwoodiae is a pinkish plant with pink, rounded and often erose tepals, with 8–9 stamens per flower. Morphological differences and comparative DNA sequencing indicate the two varieties are better treated as separate species. A new combination (C. eastwoodiae comb. et stat. nov.) is proposed and typification of the name C. angustifolia is clarified. A comparison table of closely related Chorizanthe is provided.
Ultra-Low Threshold Broadband Soliton Frequency Comb Generation

We measure a record-low threshold power of 84 μW for parametric oscillation using resonators with intrinsic Q of 31.8 ± 4.4 million and demonstrate a broadband single soliton comb spectrum spanning 1097 nm-2040 nm (126 THz). The resonator compact profile is designed to minimize higher order modes excitation.
Diel Variability and Influence of Artificial Light on Fish and Macroinvertebrate Communities in Gulf of Mexico Seagrass Beds

Seagrasses are productive habitats that support diverse communities of economically and ecologically important fishes and macroinvertebrates. However, most seagrass faunal assessments are conducted only during daylight hours. Here, we documented diel patterns in seagrass-associated fish and macroinvertebrate community structure in seagrass near Seahorse Key, Florida (USA). Artificial light is prevalent in many coastal areas and may influence day/night assemblages; therefore, we added lights to the natural environment to get a better understanding of its effect on community composition. Seagrass inhabitants were quantified using 25-m seine transects during different diel periods (day or night) and in areas where light was manipulated to mimic light pollution (artificial + natural light or natural light). Results suggest that the magnitude of diel effects exceeded that of light addition. While total abundance was similar between day and night, communities did change, with Lagodon rhomboides (Pinfish) dominating day samples and Farfantepenaeus duorarum (pink shrimp) most abundant at night. Other fishes such as Orthopristis chrysoptera (Pigfish) and Strongylura notata (Needlefish) had higher catches during the day, while invertebrates such as Callinectes sapidus (blue crab) and Palaeomonetes spp. (grass shrimp) were more prominent at night. In addition to the differences in abundance and community structure, we also identified diel differences in sizes for some species. No clear patterns were observed with the short-term addition of artificial light. This research highlights the role of diel variability in seagrass communities and suggests that diel movement of organisms may represent an important conduit for the transfer of energy to adjacent habitats.
Understanding State Agency Independence: Appendices

These three appendices accompany Understanding State Agency Independence, 117 Michigan Law Review (2019 Forthcoming) also at: http://ssrn.com/abstract=3239628).