TU-D-207A-00: Quantitative Assessment of CT Systems with Iterative Image Reconstruction Algorithms

In recent several years, motivated by the need to reduce radiation doses in CT exams, all of the major CT manufacturers have commercialized different iterative image reconstruction techniques and these innovative techniques were used in clinical routines with increasing popularity. However, due to the intrinsic nonlinearity of these new techniques, the well accepted quantitative image quality assessment metrics such as spatial resolution and contrast to noise ratio are not sufficient to provide the needed quantitative metrics for assessing image quality and for guiding the CT scan protocol optimization. This symposium aims at providing a thorough update to AAPM community on what we have understood in the past for linear CT imaging system, what are the new challenges and opportunities offered by the nonlinear iterative image reconstruction, and what would be the future directions in quantitative image quality assessment that the AAPM community can work together to address the challenges and to adapt the nonlinear image reconstruction methods to routine clinical practice to improve patient care. Three invited speakers will lead the discussions in this symposium. Dr. Ke Li from the University of Wisconsin-Madison will be presenting the new challenges introduced in model-based iterative reconstruction (MBIR) method with a focus on how the nonlinear nature of the MBIR reconstruction poses challenges in quantitative image quality metrics such as spatial resolution, noise power spectrum, and the limitations of CNR in protocol optimization which eventually leads to the need of task-based detectability index as the metric. Dr. Shuai Leng from Mayo Clinic will then present how the CNR metric is insufficient for nonlinear reconstruction algorithms, and how task based model observers can be used to more accurately quantify image quality, and to optimize imaging system and scanning protocols for nonlinear iterative image reconstruction algorithms based on specific imaging task. Practical considerations regarding the application of task based image quality metrics will also be discussed. Dr. Ehsan Samei from Duke University will start the symposium by summarizing a to-be-released AAPM Task Group report (TG 233: Performance Evaluation of Computed Tomography Systems). He will cover what has been understood and accepted for linear CT imaging system, what are the new challenges in CT image quality assessment introduced by the nonlinear iterative reconstruction (IR) techniques, and summarize both taskneutral and task-based metrologies developed in TG 233 to partially address these challenges, and foresee additional challenges in the future. Learning Objectives: 1. Understand the challenges in quantitative image quality assessment introduced by nonlinear iterative reconstruction techniques 2. Understand the challenges and methods in noise performance assessment for nonlinear iterative reconstruction techniques 3. Understand the challenges and methods in in spatial resolution assessment for nonlinear iterative reconstruction techniques 4. Understand the challenges and methods in in task-based observer performance assessment for nonlinear iterative reconstruction techniques Funding support received from NIH and DOD; Funding support received from GE Healthcare; Funding support received from Siemens AX; Patent royalties received from GE Healthcare; S. Leng, R01 EB071095; U01 EB017185; E. Samei, Research grant, Siemens; Research grant, GE; K. Li, Funding from NIH, DOD and AAPM