cssi/SciSciGPT-SciSciNet huggingface dataset:
Posttraumatic stress and depression: potential pathways to disease burden among heart failure patients.

Background and Objectives: Posttraumatic stress disorder (PTSD) and Major Depressive Disorder (MDD) are associated with high disease burden. Pathways by which PTSD and MDD contribute to disease burden are not understood. Design: Path analysis was used to examine pathways between PTSD symptoms, MDD symptoms, and disease burden among 251 low-income heart failure patients. Methods: In Model 1, we explored the independent relationship between PTSD and MDD symptoms on disease burden. In Model 2, we examined the association of PTSD symptoms and disease burden on MDD symptoms. We also examined indirect associations of PTSD symptoms on MDD symptoms, mediated by disease burden, and of PTSD symptoms on disease burden mediated by MDD symptoms. Results: Disease burden correlated with PTSD symptoms (r = .41; p < .001) and MDD symptoms (r = .43; p < .001) symptoms. Both models fit the data well and displayed comparable fit. MDD symptoms did not mediate the association of PTSD symptoms with disease burden. Disease burde...
Surgical Options for Patients with Neurogenic Bladder

Neurogenic bladder encompasses many conditions that affect the bladder in patients with neurologic disease. Although there is no standard definition for neurogenic bladder, for the intent and purpose of this review, it is defined as any pathologic process affecting the central and/or peripheral nervous systems that results in urine storage or emptying dysfunction. It often presents clinically as varying degrees of urinary incontinence and/or retention but can present with urinary tract infections, urinary tract stones, or upper urinary tract deterioration. It is up to the clinician to identify wherein the problem lies—is it an outlet problem, bladder problem, or both? What is affected: storage, emptying, or both? These factors should be considered together to identify patients who may benefit from surgical intervention. This review focuses on patient evaluation and surgical interventions for adult patients with neurogenic bladder. Surgical interventions for problems with emptying due to detrusor external sphincter dyssynergia include surgical external sphincterotomy, chemical external sphincterotomy, urethral stent, and sphincter dilation. For detrusor underactivity, detrusor myoplasty and neuromodulation are discussed. For neurogenic detrusor overactivity and impaired compliance and capacity, botulinum toxin injection, sacral neuromodulation, and patch enterocystoplasty are discussed. For decreased compliance/capacity, detrusorotomy is also discussed. For combined problems, urinary diversions are also discussed.
THE EFFECTS OF 0.2 HZ VARYING LATENCY WITH 20-100 MS VARYING AMPLITUDE ON SIMULATOR SICKNESS IN A HELMET MOUNTED DISPLAY

Abstract The relationship between the occurrence of simulator sickness (SS) and varying latency in a helmet-mounted display (HMD) was explored in this study. Previous work has always considered latency to be a constant. The aim of this research was to determine if a latency that varied over time would impact the experience of SS for HMD users. An object location task was used while viewing real, live video scenes via HMD. A planned comparisons approach was utilized with four experimental conditions, 2 of them having constant latency (0 ms added to system baseline, 200 ms added to system baseline) and 2 of them having sinusoidally varying latency (100 ms amplitude at 0.2 Hz frequency, and 20–100 ms varying amplitude at 0.2 Hz frequency). These conditions allowed for the assessment of the effects of constant latency vs. varying latency on the experience of SS. The results indicated that a varying latency is associated with greater experience of SS among HMD users than constant latency. Results also indicated, as has other recent research, that added constant latency on its own does not appear to be associated with the experience of higher levels of SS in an HMD.
Probability Distribution Of Wind Retrieval Error For The Nasa Scatterometer

The NASA scatterometer (NSCAT) is a spaceborne scatterometer scheduled to be deployed in the mid-1990s. An analysis of the wind retrieval error distribution for wind estimates based on backscatter measurements made by the NSCAT instrument is presented. The results are based on an end-to-end simulation of the scatterometer instrument and data processing. In general, the distribution of the wind speed error, when normalized, is independent of the true wind speed and direction. The wind speed error can be characterized by a normal distribution. The wind direction error is independent of the true wind speed, but depends on the true wind direction. Details for wind vectors with true wind speeds from 3 m/s to 33 m/s and true wind directions from 0 to 360 deg are presented.
Absence of radiative mass shifts for composite goldstone supermultiplets

Abstract A supersymmetric Dashen type formula is used to prove that there are no radiative mass corrections for Goldstone pion supermultiplets due to gauge interactions. In partivular, for unbroken supersymmetry the charged to neutral pion mass difference is shown to vanish to all orders in electromagnetism.
Foreign names into native tongues: how to transfer sound between languages ¿ transliteration, phonological translation, nativization, and implications for translation theory

The transfer of sound from one language into another is not a uniform process, but rather, takes different forms depending on the orthographies and phonological properties of source and target languages, the less common of which involve processes significantly different from transliteration between European phonetic scripts. This paper pools techniques commonly used in loanword phonology and second language acquisition to illustrate complications that arise when translating names from English into languages such as Japanese and Chinese, which differ significantly from the source language in syllable structure and orthographic convention. Competing strategies of adaptation and accommodation are placed in the context of lexical retrieval and compared with experimental studies of nativization in interlanguage. It will be shown that for names to be perceived as similar-sounding across language boundaries, it would be desirable to look beyond segmental equivalence and consider stress, syllable count and other suprasegmental factors that play a greater role in phonological memory.
Process for selective extraction of pectins from plant material by differential pH

Extraction of natural hydrocolloid carbohydrate polymers, such as pectin, from plant matter is accomplished at somewhat elevated temperature and controlled conditions of acidity/alkalinity. In many cases the plant material contains a variety of different extractables, including non-polymeric carbohydrates (sugars) in addition to the pectins. Very recently two different kinds of pectin, a calcium-sensitive pectin (CSP) and a non-calcium-sensitive pectin (NCSP), have become interesting commercially. What is described in this work is a process to selectively extract NCSP and CSP by varying the pH of the extracting solution. In a first extraction with acidic aqueous solution, a pH between 3.0 and 3.3 without addition of polyvalent salt is sufficient to extract NCSP pectin. A second extraction under stronger acid conditions (pH of about 2.0) is sufficient to extract the remaining pectin, which is primarily CSP.
Exercise modulates antioxidant enzyme gene expression in rat myocardium and liver.

Our previous studies have shown that exercise caused changes in the tissue activities of the antioxidant enzymes glutathione peroxidase, superoxide dismutase, and catalase in spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. To determine whether the changes observed were due to changes in mRNA levels of the enzymes, levels of tissue mRNA were determined by quantitative RNase protection assay. Comparisons of tissue enzyme activities and mRNA levels in sedentary and exercised animals showed that, in some cases (e.g., glutathione peroxidase in SH and WKY myocardium), parallel changes in enzyme activity and mRNA levels occurred, whereas in other cases (e.g., catalase in SH and WKY liver), nonparallel changes were found. Exercise of hypertensive rats altered antioxidant enzyme mRNA levels to those seen in normotensive animals in some, but not all, cases. The results suggest that transcriptional control over changes in exercise-related antioxidant enzyme activities is operative in some cases, although in other cases posttranscriptional regulatory mechanisms may exist.
Flow Nonuniformities and Turbulent “Hot Spots” Due to Wake-Blade and Wake-Wake Interactions in a Multi-Stage Turbomachine

This experimental study provides striking examples of the complex flow and turbulence structure resulting from blade-wake and wake-wake interactions in a multi-stage turbomachine. Particle Image Velocimetry (PIV) measurements are performed within the entire 2 nd stage of a two-stage turbomachine. The experiments are performed in a facility that allows unobstructed view of the entire flow field, facilitated using transparent rotor and stator and a fluid that has the same optical index of refraction as the blades. This paper contains data on the phase-averaged flow structure including velocity, vorticity and strain-rate, as well as the turbulent kinetic energy and shear stress, at mid span, for several orientation of the rotor relative to the stator. Two different test setups with different blade geometries are used in order to highlight and elucidate complex phenomena involved, as well as to demonstrate that some of the interactions are characteristic to turbomachines and can be found in a variety of geometries. The first part of the paper deals with the interaction of a 2 nd
A traumatic intra-renal pseudo-aneurysm in a child

Intra-renal pseudo-aneurysms after penetrating renal trauma have not been reported in children. We report a case of a 9-year-old girl who presented with gross haematuria 2 weeks following renal exploration for a penetrating injury. The diagnosis of intra-renal pseudoaneurysm was made by Doppler ultrasound and was successfully treated by selective arterial embolisation.
Variables That May Enhance Medical Students' Perceived Preparedness for Computer-based Testing

Objective: To identify variables that may enhance medical student's preparedness for computer-based administration of the United States Medical Licensing Examination (USMLE). Design: A cross-sectional survey of 301 medical students who completed a self-administered questionnaire. Measurements: The questionnaire was designed to obtain information about students' computer resources, personal experience with computers, computer expertise, opinions about computers, experience with computer-based testing, perceived preparedness for the computer-based USMLE, and demographic variables. Variables related to students' perceived preparedness for the computer-based USMLE were identified by ordinal logistic regression. Results: A significant regression model yielded four significant predictors: perceived preparedness for USMLE content (P < 0.0001), opinions about computers (P < 0.0012), gender (P < 0.0001), and a gender by computer-based testing experience interaction (P < 0.0004). Computer resources, personal experience with computers, computer expertise, age, race, and year of medical school were not significant predictors. Conclusion: Students' perceived preparedness for computer-based administration of high-stakes examinations may be facilitated by preparing them for examination content, by enhancing their opinions about computers, and by increasing their computer-based testing experiences. n J Am Med Inform Assoc. 2000;7:469-474.
Physical activity interventions for cancer survivors

Obesity and a sedentary lifestyle are highly prevalent in cancer survivors, and a growing number of publications have shown statistically and clinically significant associations between low levels of physical activity, obesity and cancer recurrence and death. Adoption and maintenance of physical activity is a difficult challenge for healthy adults, and is likely to be even more difficult after a cancer diagnosis. More effective strategies to increase physical activity in cancer survivors should be explored. The purpose of this paper is to (1) provide a rationale for physical activity interventions and programmes for cancer survivors, and (2) discuss successful approaches to adopting and maintaining physical activity to meet evidence based recommendations and ultimately improve cancer survival and overall survival. Since a majority of cancer survivors are not currently participating in recommended levels of physical activity, resulting in greater disease risk and health care costs, targeted exercise therapy has the potential to benefit a large number of cancer survivors. Cancer survivors should seek out the opportunities that exist towards being physically active, and oncologists should also become aware of the benefits of exercise, assist their patients by endorsing existing physical activity guidelines, and refer their patients to certified cancer exercise trainers.
Characterization of a JFET operational amplifier by planned experimentation and its impact on IC manufacturing

Statistical process characterization has become an essential tool in advanced IC manufacturing to improve product quality, yield, and manufacturing efficiency. The device parameter drift of a JFET operational amplifier is discussed in terms of yield loss and product quality of analog ICs. Planned statistical experimentation was used to identify process factors that were causing the drift. The mechanisms for operational amplifier parameter drift, the improvements using statistical process characterization, and the resultant analog IC yield enhancement are described. >
Extending life: scientific prospects and political obstacles.

In t he l ast t wo d ecades, b iogerontologist s h ave found that the pace of aging can be decelerated in mammals by dietary or genetic means. Though still largely unappreciated by the lay and scientific public alike, these discoveries belie the common assumption that human aging probably cannot be slowed and prompt the question of whether we can use our growing knowledge about aging to produce 90-year-old adults who are as healthy and active as today’s 50-year-olds. This article explores three related issues: first, why discussions of antiaging medicines are no longer silly; next, why the development of antiaging strategies is making so little headway; and last, whether further work in this area would be worthwhile. By “aging” I mean a process that converts healthy young adults into less healthy older ones with an increasing risk of illness and death. This definition, which seems fairly innocuous, is careful enough to be controversial, because there are many interesting areas of investigation— studies of childhood development; specific late-life diseases; death or proliferative ennui of cells in culture; leaf abscission; and time-dependent changes in the chemical composition of wines, cheeses, and bones—that are sometimes proposed in various combinations as worthy of gerontological attention and governmental funding. Each of these areas may
Evaluation of wall motion and dynamic geometry of the inferior vena cava using intravascular ultrasound: implications for future device design.

Purpose:To use intravascular ultrasound (IVUS) to define the wall motion of the inferior vena cava (IVC) during normal respiratory cycles and evaluate its dynamic geometry during Valsalva maneuvers.Methods:Between September 2005 and October 2006, 10 patients who were having IVC filters placed underwent IVUS prior to filter implantation. With the anesthetized patient in a supine position, a 10-second IVUS recording of IVC motion below the renal veins was made during both normal respiratory cycles and Valsalva maneuvers. Diameters (n=100 measurements) were measured from the epicenter of the lumen in both a long and short axis. Changes in diameters were evaluated using a Student t test for paired data; variations in IVC wall motion circumference of the vessel were compared using an analysis of variance for repeated measurements. Intra-/interobserver variability was analyzed with Bland-Altman plots.Results:The mean IVC diameter was 14.3±4.1 mm in the short axis and 23.2±3.5 mm in the long axis. There was sign...
The Unlettered University

planning, spurning both creative teaching and the rigorous pursuit of knowledge. Now that higher education is viewed largely as a passport to the job market, can we again create an institution and a curriculum that recognizes the value of learning for its own sake? Exposure to a range of perspectives on human behavior is essential to education. All that we know about ourselves and our world is codified
Sol-gel-derived 4×4 multimode interference coupler: optimization and fabrication

The design and fabrication of a 434 multimode interference (MMI) coupler is reported. A photopatternable organic-inorganic sol-gel on silica-on-silicon is adopted for the device fabrication. Optimization of waveguide parameters led to the coupler excess loss below 1 dB and power imbalance below 0.2 dB. An optical 90-deg hybrid based on the coupler is realized and tested. The experimental data are in very good agreement with predicted simulation results, demonstrating the simplicity and exactness of the sol-gel method as an advantageous fabrication route in integrated optics. © 2004 Society of Photo-Optical Instrumentation Engi- neers. (DOI: 10.1117/1.1646180)
Purification and properties of a prolyl endopeptidase from rabbit brain.

— An enzyme with the specificity of a prolyl endopeptidase was purified about 880-fold from rabbit brain. The enzyme hydrolyzes peptidylprolyl-peptide and peptidylprolyl-amino acid bonds. Several biologically active peptides such as angiotensin, bradykinin, neurotensin. substance P and thyrotropin releasing hormone are degraded by hydrolysis of the bond between the carboxyl group of proline and the adjacent amino acid or ammonia respectively. The enzyme is activated by dithiothreitol and inhibited by heavy metals and thiol blocking agents. The serine protease inhibitor phenylmethanesulfonylfluoride has no effect on activity; however, inhibition was obtained with diisopropylfluorophosphate. Prolyl endopeptidase has a molecular weight of about 66,000 and a pH optimum of about 8.3. A new chromogenic substrate, N-benzyloxycarbonylglycyl-L-prolylsulfamethoxazole, was used for determination of enzyme activity. The substrate is hydrolyzed to N-benzyloxycarbonylglycyl-L-proline and free sulfamethoxazole which can be conveniently determined by a colorimetric procedure.
Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors

The clinical efficacy of epidermal growth factor receptor (EGFR) kinase inhibitors is limited by the development of drug resistance. The irreversible EGFR kinase inhibitor WZ4002 is effective against the most common mechanism of drug resistance mediated by the EGFR T790M mutation. Here, we show, in multiple complementary models, that resistance to WZ4002 develops through aberrant activation of extracellular signal-regulated kinase (ERK) signaling caused by either an amplification of mitogen-activated protein kinase 1 (MAPK1) or by downregulation of negative regulators of ERK signaling. Inhibition of MAP-ERK kinase (MEK) or ERK restores sensitivity to WZ4002 and prevents the emergence of drug resistance. We further identify MAPK1 amplification in an erlotinib-resistant EGFR-mutant non-small cell lung carcinoma patient. In addition, the WZ4002-resistant MAPK1-amplified cells also show an increase both in EGFR internalization and a decrease in sensitivity to cytotoxic chemotherapy. Our findings provide insights into mechanisms of drug resistance to EGFR kinase inhibitors and highlight rational combination therapies that should be evaluated in clinical trials.
The (In)Stability Of The Relationship Between Stocks, Bonds And Managed Futures

This study re-examines the traditional belief that futures contracts have very low and, in some cases, negative correlations with stocks and bonds. Specifically, it looks at the stability of the correlations between five indices of futures market performance and two stock and bond indices over various holding periods. Results show that large positive correlations occur over short holding periods, but over the long run, the relationship is fairly stable, in particular for certain indices.
The ratio NO2NO in fuel-lean flames

Abstract In fuel-lean premixed flames at atmospheric pressure, containing about 100 ppm of nitrogen oxides, the ratio NO 2 NO is large in the primary reaction zone. The ratio decreases in the post-flame gas where super-equilibrium concentrations of O, OH, etc., also decrease. During the decrease, the equilibrium NO + O = NO 2 is approximately satisfied, and a possible mechanism to maintain (2) can be suggested. The equilibrium fails in cooler gas: At around 1200 °K or less, NO 2 NO is quenched and no longer remains balanced with the concentration of O atoms.
Dynamic Electrical and Electromechanical Properties of Carbon-Black Loaded Rubber

Abstract 1. Low-frequency resistance can be dominated by contacts. It was found that silver paint contacts were roughly equivalent to metal contacts bonded during vulcanization. 2. Three electrical...
sp-9-Acetyl­fluorene, the initial acetyl­ation product of 9-fluorenyl­lithium

The reaction of 9-fluorenyl­lithium with acetyl chloride (tetra­hydro­furan, 213 K, under argon) provided four products which we have isolated and whose structures we have unequivocally identified for the first time. That of the initially formed component, 9-acetyl­fluorene (C15H12O), described here, shows it to be exclusively the sp rotamer in its crystalline form. The acetyl C—C=O plane is essentially perpendicular to the planar fluorene ring and there is no indication of rotational restriction. In contrast, related 9-pivaloyl­fluorene, which we reported previously, is rotationally restricted and exists exclusively as its ap rotamer, in which the pivaloyl C—C=O plane is also almost perpendicular to the fluorene ring.
Finding alternatives when a major database is gone

Question: What to do when a major database ceases publication? Setting: An urban, academic health sciences library with four campuses serves a university health sciences system, a college of medicine, and five other health sciences colleges. Methods: Usage statistics of each e-book title in the resource were carefully analyzed. Purchase decisions were made based on the assessment of usage. Results: Sustainable resources were acquired from other vendors, with perpetual access for library users. Conclusion: This systematic process of finding alternative resources is an example of librarians’ persistence in acquiring perpetual electronic resources when a major resource is cancelled.
Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids

A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. This platform is anticipated to provide insightful information about an individual’s health state such as heavy metal exposure and aid the related clinic...
Study on the Efficiency of Network Academic Resources Utilization Based on Web Citations

With the development of computer network technology,network academic resources have got more and more attentions,and their influences on academic communication has increased.One of the most important marks is that the appearance of network academic resources as quotations in academic papers is becoming universal.This paper mainly selects five library and information journals: Journal of The China Society For Scientific and Technical Information、Document,Informaiton Knowledge 、 Library and information、Information Studies: Theory and Application and the Journal of the Library Science in China.Web citations of the publication year,quantity,domain names and text format are analyzed to discuss the use efficiency of network academic resources.
Role of membrane potential in hypoxic inhibition of L-arginine uptake by lung endothelial cells.

System y + accounts for the majority of L-arginine transport by pulmonary artery endothelial cells (PAEC). Given that membrane potential is a driving force for transport via system y + , we examined the hypothesis that hypoxia inhibits this transport by decreasing membrane potential. Porcine PAEC or plasma membrane vesicles derived from these cells were exposed to normoxia (room air-5% CO 2 or hypoxia (0% O 2 -95% N2-5% CO 2 ). After exposure, L-[ 3 H]arginine transport and/or accumulation of the lipophilic cation [ 3 H]tetraphenylphosphonium, a quantitative sensor of changes in cell membrane potential, were measured. Hypoxia caused reversible time-dependent decreases in L-arginine transport and membrane potential in PAEC and in plasma membrane vesicles. Comparable decreases in membrane potential and L-arginine transport by PAEC were also observed after depolarization induced by KCl or ouabain. Hyperpolarization, induced by valinomycin, increased membrane potential and L-arginine transport in PAEC and plasma membrane vesicles. Valinomycin also prevented the hypoxia-mediated decreases in membrane potential and L-arginine transport in PAEC. These results indicate that hypoxia-induced plasma membrane depolarization is responsible for reduced L-arginine transport by system y + in hypoxic porcine PAEC.
Synthesis of freestanding single-crystal perovskite films and heterostructures by etching of sacrificial water-soluble layers

The use of a sacrificial layer of water-soluble Sr3Al2O6 allows the release of freestanding 2D heterostructures and superlattices of epitaxially grown perovskite oxides while preserving their structural and physical properties. The ability to create and manipulate materials in two-dimensional (2D) form has repeatedly had transformative impact on science and technology. In parallel with the exfoliation and stacking of intrinsically layered crystals1,2,3,4,5, atomic-scale thin film growth of complex materials has enabled the creation of artificial 2D heterostructures with novel functionality6,7,8,9 and emergent phenomena, as seen in perovskite heterostructures10,11,12. However, separation of these layers from the growth substrate has proved challenging, limiting the manipulation capabilities of these heterostructures with respect to exfoliated materials. Here we present a general method to create freestanding perovskite membranes. The key is the epitaxial growth of water-soluble Sr3Al2O6 on perovskite substrates, followed by in situ growth of films and heterostructures. Millimetre-size single-crystalline membranes are produced by etching the Sr3Al2O6 layer in water, providing the opportunity to transfer them to arbitrary substrates and integrate them with heterostructures of semiconductors and layered compounds13,14.
Imitation and Adaptation: A Meeting of Minds

AbstractThe focus of this collaborative paper is a form of creative collaboration: translations and adaptations across distinct historical periods and cultural contexts. The paper draws upon Edward H. Friedman's experience as an adaptor and translator, and both participants' research and scholarly work. The paper focuses on the choices made by adaptors in considering the time, place and contexts of the original while bearing in mind the exigencies and the sensibilities of the present. There is no doubt that the practice of imitatio in the Early Modern period and current practices of spin-offs and remakes differ significantly; however, this project reflects upon what Early Modernists can learn from the contemporary adaptations and stagings of the texts we study and teach. This question was central to Emilie Bergmann’s recent cross-cultural seminar on Renaissance and Baroque imitatio and centuries of translations and adaptations into French prose and theatre (Lesage and Moliere) and Italian opera (Don Giova...
Thanks to Class of 1980

To the Editor: I would like to commend Rosemary Scully and Richard Cox on their fine study and its presentation: “Class of 1980” (Phys Ther, July 1982). It was a delightful surprise to find that someone had finally taken the time to perform a succinct, demographic study of students' career choices and plans. Many thanks to you and to Physical Therapy for publishing it. While recognizing all the limitations of such a study, as duly reported by Mr. Morrow (“Commentary,” Phys Ther, July 1982), the results do have significant implications for educational institutions as they plan recruitment efforts and for potential employers of physical therapists. The serious problem of manpower maldistribution in physical therapy, particularly in underserved rural areas, is one that educators and program planners must begin to address.… [ ARTICLE][1] [ ARTICLE][2] [1]: /lookup/volpage/62/998?iss=7 [2]: /lookup/volpage/62/1005?iss=7
Posttraumatic Stress Disorder and Emotion-Focused Coping Among Disaster Mental Health Counselors

The authors surveyed 235 disaster mental health counselors (DMHCs) for levels of posttraumatic stress disorder (PTSD) symptom severity. A correlational design was used to examine the roles of adult attachment security, emotion regulation, and mindfulness in predicting PTSD symptoms among this group. Each of the 3 predictors was negatively correlated with PTSD symptom severity, and data supported a mediating role for emotion regulation. Results may inform DMHCs, other counselors, and individuals who train or deploy DMHCs.
Suspected Ofloxacin-Induced Seizures in an Elderly Patient

Objective:To report a case of probable ofloxacin-induced seizures.Case Summary:A 74-year-old white man received a single intravenous dose of ofloxacin administered over a 60-minute period. Approxim...
Design and analysis of siloxanes removal by adsorption from landfill gas for waste-to-energy processes.

Abstract Separation of volatile methyl siloxanes from landfill gas using fixed adsorption beds was modeled with the objective of identifying appropriate technology and the economics associated with this purification step. A general adsorption model assuming plug flow and radial symmetry was developed and used to conduct a parametric sweep of 162 unique cases. The varied parameters were adsorbent type (activated carbon and silica gel), bed height (3.05–9.15 m/10–30 ft), inlet siloxane concentration (5–15 mg/m3), moisture content (0–100% relative humidity at STP or RH), and siloxane tolerance limit (0.094–9.4 mg/m3) that correlated to three distinct energy conversion technologies (electricity production using engines or fuels cells or catalytic conversion to liquid hydrocarbon fuels). Due to the detrimental effect of RH on siloxane absorption, the maximum allowable moisture content of LFG before purification is 50% RH and moisture removal processes are also required. The design calculations using a selected case study show that the adsorption bed height required needed for 6 months minimum breakthrough time for catalytic fuel production is twice that for engine applications. Fuel cell applications require 3 times the bed height compared to engine applications. However, the purification costs amounted to 94%, 16% and 52% of recovered product value for engine, liquefaction, and fuel cell applications, respectively indicating the need for a high value product to justify purification costs. The approaches and conclusions can be extended to specific process conditions for landfill gas purification and to other processes that use biogas produced from waste as a feedstock.
Engineering a simple lateral flow device for animal blood coagulation monitoring

Increasing numbers of animals are diagnosed with thromboembolism, requiring anticoagulation treatment to prevent thrombotic events. Frequent and periodic coagulation monitoring is critical to ensure treatment effectiveness and patient safety by limiting blood coagulation ability within the desired therapeutic range. Point-of-care diagnostics is an ideal candidate for frequent coagulation monitoring due to rapid test results and no need for laboratory setting. This article reports the first utilization of no-reaction lateral flow assay (nrLFA) device for simple and low-cost animal blood coagulation monitoring in resource-limited setting. The nrLFA device consists of sample pad, analytical membrane and wicking pad, without conjugate pad, reagent printing or membrane drying. Citrated and heparinized animal blood were utilized to mimic different blood coagulation abilities in vitro by adding reversal agents CaCl2 and protamine sulfate. The travel distance of red blood cells (RBCs) on the nrLFA after a pre-determined test time serves as endpoint marker. Upon adding 500 mM CaCl2 solution to citrated bovine, canine, rabbit and equine blood, the average travel distance decreases from 10.9 to 9.4 mm, 8.8 to 5.7 mm, 12.6 to 9 mm, and 15.3 to 11.3 mm, respectively. For heparinized bovine and rabbit blood, the average distance decreases from 14.5 to 11.4 mm and from 9.8 to 7.2 mm, respectively, when adding 300 mg/l protamine sulfate solution. The effect of hematocrit on RBC travel distance in the nrLFA was also investigated. The nrLFA device will potentially improve treatment efficiency, patient safety, quality of life, and satisfaction for both animal patients and their owners.
Accessibility and Mobility of Persons who are Visually Impaired: A Historical Analysis:

Traveling without sight presents challenges and, for some individuals, significant limitations. This article traces the historical development of two movements—orientation and mobility training and...
THE EFFECT OF EARLY EXPERIENCE ON MHC-BASED MATE PREFERENCES IN TWO B10.W STRAINS OF MICE (MUS DOMESTICUS)

Previous experiments have demonstrated that mice of some strains show mate preferences that are based on genes of the major histocompatibility complex (MHC), and rearing environment appears to influence these preferences. This experiment investigated if fostering affected MHC-based mate preferences in two additional strains of mice for which it was known that females exhibited MHC-dissimilar preferences. Pups were exchanged between families of B10.GAA37 and B10.CHR51 mouse strains, which differed genetically from one another only at MHC loci. At sexual maturity foster mice were given a choice of two opposite-sex mice of either the foster-family or the foster-mouse MHC type. Preference was based on time spent with each stimulus mouse, the first ejaculation, or the first mount with a stimulus mouse. Although the results were not significant in general, females of the B10.GAA37 strain were mounted first significantly more often by non-foster-family males; first mounts predicted ejaculation preference. The results suggest that rearing environment did affect MHC-based preferences in females of this strain, although learning of self-MHC cues and use of non-MHC cues for mate choice may also occur. These results are compared to those of previous experiments.
Accounting for mathematicians’ priorities in mathematics courses for secondary teachers

Abstract Recent studies suggest that change is needed in undergraduate mathematics capstone courses for prospective secondary teachers. One promising but infrequently used strategy for improvement is to incorporate tasks that explicitly focus on pedagogical content knowledge (PCK). Expectancy-value theory provides an account for why instruction of these courses does not more regularly employ this strategy. To make this argument, this paper uses an interview-based study of 9 mathematicians that investigated the process of prioritizing tasks and goals for these courses. As the study found, these mathematicians valued developing teachers’ PCK. However, they were unconfident of their ability to teach with tasks and goals focused on developing teachers’ PCK relative to more purely mathematical tasks and goals. The central implication is that interventions in mathematicians’ teaching must take into account the possibility that it may be just as important to improve confidence and resources as it is to change values.
Helios+ and Helios- Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.

The transcription factor Helios is expressed in a large subset of Foxp3+ Tregs. We previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios- Treg were induced from Foxp3- T conventional (Tconv) cells in the periphery (pTreg). To compare the two Treg subpopulations, we generated Helios-GFP reporter mice and crossed them to Foxp3-RFP reporter mice. The Helios+ Treg population expressed a more activated phenotype, had a slightly higher suppressive capacity in vitro and expressed a more highly demethylated TSDR but were equivalent in their ability to suppress inflammatory bowel disease in vivo. However, Helios+ Treg more effectively inhibited the proliferation of activated, autoreactive splenocytes from scurfy mice. When Helios+ and Helios- Treg were transferred to lymphoreplete mice, both populations maintained comparable Foxp3 expression, but Foxp3 expression was less stable in Helios- Treg when transferred to lymphopenic mice. Gene expression profiling demonstrated a large number of differentially expressed genes and showed that Helios- Treg expressed certain genes normally expressed in CD4+ Foxp3- T cells. TCR repertoire analysis indicated very little overlap between Helios+ and Helios- Treg. Thus, Helios+ and Helios- Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.
Maggot debridement therapy: A practical review

Maggot debridement therapy (MDT) has a long and well-documented history. Once a popular wound care treatment, especially prior to the discovery of antibiotics, modern dressings or debridement techniques, MDT fell out of favor after the 1940s. With the increasing prevalence of chronic medical conditions and associated complex and difficult-to-treat wounds, new approaches have become necessary to address emerging issues such as antibiotic resistance, bacterial biofilm persistence and the high cost of advanced wound therapies. The constant search for a dressing and/or medical device that will control pain, remove bacteria/biofilm, and selectively debride necrotic wound material, all while promoting the growth of healthy new tissue, remains elusive. On review of the current literature, MDT comes very close to addressing all of the previously mentioned factors, while at the same time remaining cost-effective. Complications of MDT are rare and side effects are minimal. If patients and providers can look past the obvious anxiety associated with the management and presence of larvae, they will quickly see the benefits of this underutilized modality for healing multiple types of wounds. The following core competencies are addressed in this article: Medical knowledge, Patient care, Practice-based learning and improvement.
Unraveling driving forces explaining significant reduction in satellite-inferred Arctic surface albedo since the 1980s

The Arctic has warmed significantly since the early 1980s and much of this warming can be attributed to the surface albedo feedback. In this study, satellite observations reveal a 1.25 to 1.51% per decade absolute reduction in the Arctic mean surface albedo in spring and summer during 1982 to 2014. Results from a global model and reanalysis data are used to unravel the causes of this albedo reduction. We find that reductions of terrestrial snow cover, snow cover fraction over sea ice, and sea ice extent appear to contribute equally to the Arctic albedo decline. We show that the decrease in snow cover fraction is primarily driven by the increase in surface air temperature, followed by declining snowfall. Although the total precipitation has increased as the Arctic warms, Arctic snowfall is reduced substantially in all analyzed data sets. Light-absorbing soot in snow has been decreasing in past decades over the Arctic, indicating that soot heating has not been the driver of changes in the Arctic snow cover, ice cover, and surface albedo since the 1980s.
Tongue Part Movement Trajectories for /r/ Using Ultrasound

Purpose Because it shows the movement of different parts of the tongue in real time, ultrasound biofeedback therapy is a promising technology for speech research and remediation. One limitation is ...
Hematopoietic stem cell transplantation for blood cancers in the era of precision medicine and immunotherapy.

Hematopoietic stem cell transplantation (HCT) has been an integral component in the treatment of many hematologic malignancies. Since the development of HCT nearly 50 years ago, the role of this modality has evolved as newer treatment approaches have been developed and integrated into the standard of care. In the last decade, novel and highly active targeted therapies and immunotherapies have been approved for many hematologic malignancies, raising the question of whether HCT continues to retain its prominent role in the treatment paradigms of various hematologic malignancies. In this review, the authors have described the current role of autologous and allogeneic HCT in the treatment of patients with acute leukemias, aggressive B-cell lymphomas, and multiple myeloma and discussed how novel targeted therapies and immunotherapies have changed the potential need, timing, and goal of HCT in patients with these diseases.
Transcription factor ID1 is involved in decidualization of stromal cells: Implications in preeclampsia

Decidual stromal cells (DSC) from women with preeclampsia (PE) show defective decidualization upon in vitro treatment with cAMP. Decidualization is associated with a multitude of gene expression changes and is a prerequisite for embryo implantation. We reason that the process of decidualization involves a cascade of changes in transcriptional regulators. Our prior studies have found defective decidualization of PE-DSCs as reflected by low prolactin (PRL) levels and other decidualization markers. Transcription factor array analysis identified inhibitor of DNA binding (ID1) and FOXO1 as top differentially expressed genes during decidualization. Unlike ID1, FOXO1 involvement in decidualization has been established. We hypothesized that ID1 plays a major role in regulating stromal cell decidualization. Our data shows basal ID1 mRNA expression is significantly higher in PE DSCs. Cyclic AMP-mediated decidualization significantly upregulates ID1 mRNA expression in DSCs and siRNA-mediated knockdown of ID1 significantly interferes with decidualization as shown by a reduction in PRL and FOXO1 expression, and morphologic criteria. Thus ID1 may serve as a master regulator of stromal cell differentiation and defects in ID1 expression may affect decidualization as seen in PE-DSCs.
Machine-learning-assisted fabrication: Bayesian optimization of laser-induced graphene patterning using in-situ Raman analysis

Abstract The control of the physical, chemical, and electronic properties of laser-induced graphene (LIG) is crucial in the fabrication of flexible electronic devices. However, the optimization of LIG production is time-consuming and costly. Here, we demonstrate state-of-the-art automated parameter tuning techniques using Bayesian optimization to advance rapid single-step laser patterning and structuring capabilities with a view to fabricate graphene-based electronic devices. In particular, a large search space of parameters for LIG explored efficiently. As a result, high-quality LIG patterns exhibiting high Raman G/D ratios at least a factor of four larger than those found in the literature were achieved within 50 optimization iterations in which the laser power, irradiation time, pressure and type of gas were optimized. Human-interpretable conclusions may be derived from our machine learning model to aid our understanding of the underlying mechanism for substrate-dependent LIG growth, e.g. high-quality graphene patterns are obtained at low and high gas pressures for quartz and polyimide, respectively. Our Bayesian optimization search method allows for an efficient experimental design that is independent of the experience and skills of individual researchers, while reducing experimental time and cost and accelerating materials research.
A Grounded Theory Study of Burnout among Youth Workers in Korean Immigrant Churches

This research aimed to explore the factors that contribute to burnout among Korean (American) youth workers. Twenty youth workers serving at Korean immigrant churches in California participated in ...
Bigger or Smaller? Size and Loading Effects on Nanoparticle Uptake Efficiency in the Nasal Mucosa

PLGA nanoparticles hold great promise for nasal administration, but only with careful design will efficient, effective, and safe delivery systems be developed. To better understand the size dependence of nasal epithelial uptake, PLGA nanoparticles (60 nm or 125 nm) loaded with Nile Red were prepared, and their uptake into excised sections of bovine nasal respiratory or olfactory mucosa was measured for 30 or 60 min. The epithelial layer and the submucosal tissues were separated, and the amount of Nile Red was used to calculate the number of nanoparticles in each tissue region. Both particle sizes were able to be internalized into the nasal tissues in as little as 30 min, but their total uptake represented less than 5% of the nanoparticles available. Nanoparticles were present both in the epithelial cells and in the submucosal tissues, and greater numbers of the 60-nm particles were present in the submucosa than the epithelium, while greater numbers of the 125-nm particles remained in the epithelial cell layer. The amount of Nile Red recovered from the mucosal tissues after exposure to 125-nm nanoparticles was at least 2-fold greater than from the 60-nm nanoparticles, however, due to the higher (~ 9-fold) loading capacity of the larger particles. The greater mass transfer of the Nile Red from the larger particles suggests that it may not be necessary to develop small nanoparticulate delivery systems for efficient drug delivery via the nasal mucosa. Well-designed nanoparticles with diameters > 100 nm show good uptake into the nasal epithelium and are capable of transfer to the submucosal tissues, near the location of significant populations of blood and lymphatic vessels.