cssi/SciSciGPT-SciSciNet huggingface dataset:
Exogenous thymosin β4 prevents apoptosis in human intervertebral annulus cells in vitro

AbstractLoss of cells in the human disc due to programmed cell death (apoptosis) is a major factor in the aging and degenerating human intervertebral disc. Our objective here was to determine if thymosin β4 (TB4), a small, multifunctional 5kDa protein with diverse activities, might block apoptosis in human annulus cells cultured in monolayer or three-dimensional (3D) culture. Apoptosis was induced in vitro using hydrogen peroxide or serum starvation. Annulus cells were processed for identification of apoptotic cells using the TUNEL method. The percentage of apoptotic cells was determined by cell counts. Annulus cells also were treated with TB4 for determination of proliferation, and proteoglycan production was assessed using cell titer and 1,2 dimethylmethylamine (DMB) assays and histological staining. A significant reduction in disc cell apoptosis occurred after TB4 treatment. The percentage of cells undergoing apoptosis decreased significantly in TB4 treated cells in both apoptosis induction designs. TB...
The Contribution of Graphophonological-Semantic Flexibility to Reading Comprehension in College Students: Implications for a Less Simple View of Reading

Reading is complex and requires that individuals process many types of information concurrently. Contemporary perspectives on cognitive development focus on the ability to process cognitively complex stimuli, indicate cognitive development is domain-specific, and suggest cognitive development occurs across the lifespan. Yet little work has examined reading-specific cognitive developmental variation and its contribution to skilled reading. This study investigated the contribution of a measure of reading-specific cognitive development,graphophonological-semantic flexibility (the ability to process concurrently phonological and semantic information associated with print), to reading comprehension in college students. Graphophonological-semantic flexibility made a unique contribution to adults’ reading comprehension over phonological and semantic processing assessedindependently, even when general cognitive ability was controlled. Implications for the simple view of reading are discussed.
Monocyte Expressed Macromolecular C1 and C1q Receptors as Molecular Sensors of Danger: Implications in SLE

The ability of circulating blood monocytes to express C1q receptors (cC1qR and gC1qR)synthesize and secrete the classical pathway proteins C1q, C1r and C1s and their regulator, C1-INH is very well established. What is intriguing however is that, in addition to secretion of the individual proteins monocytes are able to display macromolecular C1 on their surface in a manner that is stable and functional. The cell surface C1 complex is presumably formed by a Ca2+–dependent association of the C1r2.C1s2 tetramer to C1q, which in turn is anchored via a membrane-binding domain located in the N-terminus of its A-chain as shown previously. Monocytes, which circulate in the blood for 1-3 days before they move into tissues throughout the body, not only serve as precursors of macrophages and dendritic cells, but also fulfill three main functions in the immune system: phagocytosis, antigen presentation, and cytokine production. Since the globular heads of C1q within the membrane associated C1 are displayed outwardly, we hypothesize that their main function-especially in circulating monocytes–is to recognize and capture circulating immune complexes or pathogen-associated molecular patterns in the blood. This in turn may give crucial signal, which drives the monocytes to migrate into tissues, differentiate into macrophages or dendritic cells, and initiate the process of antigen elimination. Unoccupied C1q on the other hand may serve to keep monocytes in a pre-dendritic phenotype by silencing key molecular players thus ensuring that unwarranted DC-driven immune response does not occur. In this paper we will discuss the role of monocyte/DC-associated C1q receptors, macromolecular C1 as well as secreted C1q in both innate and acquired immune responses.
A computational approach to dynamic bipedal walking

The main contribution of this work is a general method for stabilization of periodic orbits for hybrid systems with impact effects. Our primary motivation is controller synthesis for walking robots, but the method can be also applied to problems such as flight control or automotive control. Limit cycles of hybrid systems are characterized by the fact that they span different dynamic regimes. For smooth systems, dynamics of the system along the limit cycle can be decomposed into the transverse and tangential components. We demonstrate that this decomposition can be adapted to hybrid systems. Furthermore, we show that when the transverse dynamics is linearized and discretized, the resulting robust control synthesis problem can be cast as a semidefinite program and thus efficiently solved. We demonstrate our results through the simulation on a simple planar biped robot.
Dynamic Indices of Preload

Hypotension and shock are important issues confronting the intensivist. Volume overload can have dire consequences such as decreased gas exchange and increased myocardial dysfunction. This article explores dynamic means of determining preload responsiveness.
Characterization of Optomechanical RF frequency Mixing/Down-Conversion and its Application in Photonic RF Receivers

We have characterized the process of radio-frequency (RF) frequency mixing and signal down-conversion in radiation pressure driven optomechanical RF oscillators. We have studied the dependence of the optomechanical mixing process on RF frequency, optical pump power and wavelength detuning and verified the existence of a linear regime where down-converted power is proportional to the RF input power. These outcomes show that optomechanical oscillator (OMO) has the potential to be used as frequency down-converter in RF over fiber links and photonic RF receivers. We have verified the fidelity of the optomechanical down-conversion process and demonstrated the first optomechanical voice down-conversion from an RF carrier.
Development of a position and force sensor for robotic applications

A position/force sensor is developed to determine the position, distribution and magnitude of the load applied by an object on the sensor. For robotic applications, the sensor can be attached to grippers to aid in determining the relative pose between object and gripper, as well as in determining three forces and three moments. The sensor is designed to function as a tactile sensor and a robot wrist force sensor. Theory of plates is employed for sensor design. Strains are measured from direct contact to provide more precise position and force information. Control algorithns for robot hand motion during assembly are developed from the study and understanding of parts mating.
Precision Tunable Silicon Compatible Microring Filters

Microring resonators can be used as passband filters for wavelength-division demultiplexing in electronic-photonic integrated circuits. For applications such as analog-to-digital converters, the resonant frequency of the filter has to be held at a certain value to allow minimum timing errors in the sampling of the signal. Thermal tuning is used to compensate for any fabrication errors or environmental temperature fluctuations that might lead to a shift in the resonant frequency. With an optimized heater design, we demonstrate efficient on-chip thermal tuning for a second-order silicon-rich silicon nitride microring resonator at 80 mu W/GHz. A closed-loop feedback circuit controls a resistive heater which is also used as a temperature sensor to maintain the resonant frequency within 280 MHz of the target value.
Variance models for project financial risk analysis with applications to greenfield BOT highway projects

Assessment of BOT project financial risk is generally performed by combining Monte Carlo simulation with discounted cash flow analysis. The outcomes of this risk assessment depend, to a significant extent, upon the total project uncertainty, which aggregates aleatory and epistemic uncertainties of key risk variables. Unlike aleatory uncertainty, modelling epistemic uncertainty is a rather difficult endeavour. In fact, BOT epistemic uncertainty may vary according to the significant information disclosed during the concession period. Two properties generally characterize the stochastic behaviour of the uncertainty of BOT epistemic variables: (1) the learning property and (2) the increasing uncertainty property. A new family of Markovian processes, the Martingale variance model and the general variance model, are proposed as an alternative modelling tool for BOT risk variables. Unlike current stochastic models, the proposed models can be adapted to incorporate a risk analyst's view of properties (1) and (2)....
Biophysics Teaching Programs Available in the United States and Canada

A survey of biophysics teaching programs shows that at least 68 institutions in the United States and Canada now offer such programs, and more will be started in the near future. A classification of types of program is given, together with pertinent statistics. Despite a wide diversity of interests and administrative organization, a remarkable degree of agreement on the requirements of biophysics as a discipline is disclosed.
Thematic analysis of tiles painted by blood and marrow transplant patients during treatment

The majority of research on understanding the illness focuses on analysing the written or verbal content. Thematic analysis of images is a novel qualitative approach that can enhance knowledge of the experience of illness. This study used thematic analysis to examine 171 tiles painted by patients through the Tiles of Hope programme in an outpatient blood and marrow transplant unit. Major themes identified in this study were Faith, Hope, Positive Attitude, Nature and Social Support. These themes provided a better understanding of patients' perceptions in relation to their experience with illness through the art-making process.
Functional Organization of the Porosome Complex and Associated Structures Facilitating Cellular Secretion

Porosomes, the universal secretory machinery at the cell plasma membrane, are cup-shaped supramolecular lipoprotein structures, where membrane-bound vesicles transiently dock and fuse to release in...
Cardiac dysfunction associated with trastuzumab.

The HER2/neu gene is amplified in ∼ 25% of breast cancers, leading to HER2 protein overexpression and shortened overall survival and time to relapse. Trastuzumab is a humanised, monoclonal antibody against HER2, which improves survival for women with metastatic HER2-overexpressing breast cancer and reduces the risk of recurrence in women with early stage HER2-overexpressing breast cancer. Cardiac toxicity was an unexpected finding in the pivotal Phase III trial leading to the approval of trastuzumab, and prospective cardiac monitoring has, therefore, been incorporated into more recent clinical trials of trastuzumab. This article reviews the cardiac toxicity findings in key trastuzumab clinical trials and clinical characteristics of trastuzumab-associated cardiac toxicity.
Estimation of the long-range dependence parameter of fractional ARIMA processes

In this paper, several methods for estimating long-range dependence parameters have been proposed. By far, the wavelet method is the most widely used. When a process is assumed to be second-order self-similar, a new method was introduced that uses the structure of the covariance function to estimate the Hurst parameter. The method was shown to be much faster and yield smaller confidence intervals than the wavelet method. The case was consider in this paper when the process is assumed to be fractional ARIMA and show that the new method still processes the aforementioned qualities.
From Mental Game to Cultural Praxis: A Cultural Studies Model's Implications for the Future of Sport Psychology

This paper explores the implications of a cultural studies as praxis heuristic “model” for transforming sport psychology. It provides a brief introduction to both cultural studies and sport psychology and discusses a cultural studies intersection with sport studies and sport psychology. Cultural studies, it asserts, provides one of several interrelated trajectories for future work in sport psychology. Issues such as sociocultural identity/identifi cation, agency, equity and justice, and interdisciplinarity—that are marginal if not completely eschewed in traditional sport psychology—are explicitly engaged as central concerns. Taken up through the cultural studies model, sport psychology evolves from an individual focused, quantitative, “apolitical” single discipline into a multiple identifi cation focused, difference sensitive, qualitative friendly and social justice based interdisciplinary praxis.
Quasi-Orthogonal Space-Frequency Block Codes for MIMO OFDM Channels

In this paper, we propose a novel class of Space-Frequency and Space-Time-Frequency block codes based on Quasi-Orthogonal designs, over a frequency selective Rayleigh fading channel. The proposed codes are able to achieve rate one and full diversity by exploiting the space and multipath diversity gains available in the MIMO-OFDM channel. As the simulation results show, our codes outperform the existing Space-Frequency block codes in terms of bit error rate performance. Additionally, the proposed Space-Time-Frequency code benefits from a reduced maximum likelihood decoding complexity, which is a huge simplification compared to the existing codes. We also discuss the conditions under which the maximum likelihood decoding for our proposed Quasi-Orthogonal Space-Frequency code is simplified as well.
Collection, Processing, and Banking of Umbilical Cord Blood Stem Cells for Clinical Use in Transplantation and Regenerative Medicine

Cord blood banking has been the focus of many medical centers as it can provide a virtually unlimited source of ethnically-diverse stem-cell donors. In addition, its recent use in several regenerative medicine clinical trials has further spurred the motivation to collect and bank these stem cells. In the current study, we review the latest developments in cord blood banking. We have banked over 195,000 collections at our facility. Collections were processed by either Ficoll or AXP methodologies. An average 95% processing efficiency was obtained. The overall failure rate was less than 4% in terms of samples containing too few cells to be clinically useful. Processed samples were frozen in cryovials or bags and banked in a liquid nitrogen Dewar. In conclusion, it is possible to simply and reproducibly harvest, process, and bank cord blood samples using current technology.
Network partitioning of data parallel computations

Partitioning data parallel computations across a network of heterogeneous workstations is a difficult problem for the user. We have developed a runtime partitioning method for choosing the number and type of processors to apply to a data parallel computation, and a decomposition of the data domain in order to achieve reduced completion time. The partitioning method utilizes information about the problem in the form of callback functions and uses a set of topology-specific communication functions to estimate communication costs. We show that the method makes effective partitioning decisions and has runtime overhead that is easily tolerated. In particular we show that for two implementations of a canonical stencil application, minimum elapsed times are obtained for a range of problem sizes on a network of heterogeneous workstations. >
Distinct Cortical Pathways for Music and Speech Revealed by Hypothesis-Free Voxel Decomposition

The organization of human auditory cortex remains unresolved, due in part to the small stimulus sets common to fMRI studies and the overlap of neural populations within voxels. To address these challenges, we measured fMRI responses to 165 natural sounds and inferred canonical response profiles ("components") whose weighted combinations explained voxel responses throughout auditory cortex. This analysis revealed six components, each with interpretable response characteristics despite being unconstrained by prior functional hypotheses. Four components embodied selectivity for particular acoustic features (frequency, spectrotemporal modulation, pitch). Two others exhibited pronounced selectivity for music and speech, respectively, and were not explainable by standard acoustic features. Anatomically, music and speech selectivity concentrated in distinct regions of non-primary auditory cortex. However, music selectivity was weak in raw voxel responses, and its detection required a decomposition method. Voxel decomposition identifies primary dimensions of response variation across natural sounds, revealing distinct cortical pathways for music and speech.
Stabilization of the cervical spine by anterior fusion.

This paper recounts chronologically the development and application of an original procedure for anterior fusion of the cervical spine. Twenty patients with various pathological lesions of the cervical spine were treated by this operation. No complications specifically related to this technique occu
Profiling Levels of Socially Responsible Consumer Behavior: A Cluster Analytic Approach and Its Implications for Marketing

Too often research in the area of marketing has equated socially responsible consumer behavior (SRCB) with ecologically conscious consumer behavior (ECCB) and developed a profile and subsequent marketing strategies based solely on the numbers of ECCBs performed. Socially conscious consumer behavior (SCCB) can impact particular groups within society (e.g. women, minorities, migrant workers, labor unions, etc.) or promote causes (e.g. gay rights, religious affiliation, avoidance of “sin” stocks, reduction of weapons production, etc.). Using an expanded understanding of what comprises socially responsible consumer behavior (SRCB), a cluster analysis of a national sample of adult U.S. consumers was performed. Four distinct market segments emerged. The clusters were formed based upon the respondents’ levels of ecologically and socially conscious consumer behavior. Each segment possessed unique attitudinal and demographic characteristics. The size and profile of each segment has important implications for marke...
Oriental bittersweet ( Celastrus orbiculatus ): Spreading by fire

Abstract In many forest ecosystems, fire is critical in maintaining indigenous plant communities, but can either promote or arrest the spread of invasive species depending on their regeneration niche and resprouting ability. We examined the effects of cutting and burning treatments on the vegetative response (cover, stem density) and root resources of Oriental bittersweet ( Celastrus orbiculatus ), a liana invasive to North America that was introduced from East Asia. Treatments were control, spring cut, spring burn, spring cut & burn, summer cut, fall cut, fall burn, fall cut & burn, and fall herbicide. Cover was reduced the greatest by herbicide and summer cutting treatments, but increased more in the second year on moraine soils than on sandy soils. Burning and cutting & burning combined resulted in a resprout density four times greater than stem density prior to treatment for stems C. orbiculatus during the growing season (summer) reduced total nonstructural carbohydrates by 50% below early growing season levels and 75% below dormant season levels, burning did not significantly reduce total nonstructural carbohydrates. Thus, Oriental bittersweet is quite responsive to burning as a disturbance and resprouting and root-suckering creates additional opportunities for growth and attainment of the forest canopy. The positive response of Oriental bittersweet to burning has important implications for management of invasive lianas in fire-dependent forest landscapes.
Wide-Angle electron-pair production with possibleC, T noninvariance: A speculative interpretation of hypothetical deviations from QED

We discuss one possible interpretation of hypothetical deviations from quantum electrodynamics of a particular type. The basic hypothesis of the model provides an origin for the possible enhanced sensitivity of a high-energy, wide-angle electron-pair production experiment to such deviations, and also predicts that the deviation will be in the direction of an excess of wide-angle pairs. The model is subject to a feasible experimental test through a study of the pair production process with linearly polarized photons. This is due to the circumstance that the ordinary QED matrix element vanishes in the symmetric experimental arrangement, for photons polarized normal to the plane containing the beam and the electron-pair.
Superhydrophilic and underwater superoleophobic poly(sulfobetaine methacrylate)-grafted glass fiber filters for oil-water separation.

Oil–water separation is a major problem in industries such as oil production and wastewater treatment, where millions of gallons of oil-contaminated water are produced. Zwitterionic poly(sulfobetaine methacrylate) (pSBMA) is a superhydrophilic polymer due to its strong interaction with water via electrostatic interactions. By coating surfaces of filter media with such a superhydrophilic polymer, it is expected that one can effectively separate oil and water. In this work, pSBMA was grafted onto glass fiber surfaces using surface-initiated atom transfer radical polymerization (SI-ATRP). The in-air water contact angle of the pSBMA-treated glass was 8–15°, as compared to 31° for the control untreated glass, whereas the underwater-oil contact angle of the pSBMA-grafted glass was 162–169°, as compared to 142° for the control pristine glass, suggesting that the pSBMA-grafted glass slides are superhydrophilic and underwater superoleophobic. Such superhydrophilicity and underwater superoleophobicity were realized...
Seismic velocity structure of the Juan de Fuca and Gorda plates revealed by a joint inversion of ambient noise and regional earthquakes

The crust and upper mantle seismic structure, spanning from the Juan de Fuca and Gorda spreading centers to the Cascade back arc, is imaged with full-wave propagation simulation and a joint inversion of ambient noise and regional earthquake recordings. The spreading centers have anomalously low shear wave velocity beneath the oceanic lithosphere. Around the Cobb axial seamount, we observe a low-velocity anomaly underlying a relatively thin oceanic lithosphere, indicating its influence on the Juan de Fuca ridge. The oceanic Moho is clearly defined by a P velocity increase from 6.3 km/s to 7.5 km/s at about 6 km depth beneath the seafloor. The thickness of the oceanic plates is less than 40 km prior to subduction, and the structure of the oceanic lithosphere varies both along strike and along dip. Farther landward, very low velocity anomalies are observed above the plate interface along the Cascade fore arc, indicative of subducted sediments.
Internephron coupling by conducted vasomotor responses in normotensive and spontaneously hypertensive rats

We compared conducted vasomotor responses in juxtamedullary microcirculation in normotensive Sprague-Dawley (SD) and spontaneously hypertensive rats (SHR). The goals of the study were as follows: 1...
Emotional factors involved in the evaluation of coronary artery disease.

Attention is drawn to some of the factors involved in the precipitation of symptoms in coronary artery disease, and some practical illustrations are given as to how emotional understanding helps in the practical management of those symptoms.
Core Biopsy of Lung Lesion

This section provides a comprehensive procedural report for core biopsy of lung lesion procedure with up-to-date explanatory notes, synopsis of the indications and contraindications and potential complications in an organized and practical format.
Approximation Schemes in Logic and Artificial Intelligence

Approximate reasoning is used in a variety of reasoning tasks in logic-based artificial intelligence. In this paper we present several such reasoning schemes and show how they relate and differ from the approach of Pawlak's Rough Sets.
Visual Representation: From Perceptions to Pictures

I have pointed to the rather obvious fact that pictures, unlike linguistic symbols, have a specifically and distinctively visual character that is central to its uses. That is, pictures, like words, play many roles, as does categorization, not just representation, and for the performance of their functions pictures rely directly or indirectly on their perceptual properties. In this case, we can locate the conditions for vagueness of representation in the categorization of perceptual entities and properties.
Vulnerability to alcohol-related problems: a policy brief with implications for the regulation of alcohol marketing

Background and Aims The concern that alcohol advertising can have detrimental effects on vulnerable viewers has prompted the development of codes of responsible advertising practices. This paper evaluates critically the concept of vulnerability as it applies to (1) susceptibility to alcohol-related harm and (2) susceptibility to the effects of marketing, and describes its implications for the regulation of alcohol marketing. Method We describe the findings of key published studies, review papers and expert reports to determine whether these two types of vulnerability apply to population groups defined by (1) age and developmental history; (2) personality characteristics; (3) family history of alcoholism; (4) female sex and pregnancy risk; and (5) history of alcohol dependence and recovery status. Results Developmental theory and research suggest that groups defined by younger age, incomplete neurocognitive development and a history of alcohol dependence may be particularly vulnerable because of the disproportionate harm they experience from alcohol and their increased susceptibility to alcohol marketing. Children may be more susceptible to media imagery because they do not have the ability to compensate for biases in advertising portrayals and glamorized media imagery. Conclusion Young people and people with a history of alcohol dependence appear to be especially vulnerable to alcohol marketing, warranting the development of new content and exposure guidelines focused on protecting those groups to improve current self-regulation codes promoted by the alcohol industry. If adequate protections cannot be implemented through this mechanism, statutory regulations should be considered.
Cyclin D1 Deregulation in Mantle Cell Lymphoma: Tethering of the Cyclin D1 Promoter and 3′ Immunoglobin Enhancers by CTCF and Nucleophosmin.

Translocations involving the immunoglobulin heavy chain gene locus (IgH) are common in B cell malignancies. One common target gene is cyclin D1, which is deregulated in most patients with mantle cell lymphoma (MCL) and 20–30% of patients with multiple myeloma (MM). Cyclin D1 is known not to be expressed in normal lymphocytes, yet is deregulated by IgH translocations and insertions. The molecular mechanisms of long distance cyclin D1 activation by IgH regulatory elements in B cell malignancies have been obscure. Chromatin immunoprecipitation (ChIP) assays demonstrated the presence of the CCCTC-binding factor (CTCF) at both the cyclin D1 promoter and 3′ IgH regulatory regions only in cyclin D1 expressing malignant B cell lines containing IgH translocations or insertions. The nucleolar protein nucleophosmin (B23), a newly identified CTCF interaction partner, exhibited a similar distribution in ChIP assays. Combined FISH/immunofluorescence labelling studies have shown the presence of the cyclin D1/IgH translocated locus at the outer nucleolar membrane colocalized with CTCF and nucleophosmin. Thus, tethering of the cyclin D1 promoter to the 3′ IgH regulatory regions at the nucleolar membrane by CTCF/nucleophosmin provides a mechanism for spatial juxtaposition of the cyclin D1 promoter and 3′ IgH regulatory elements. We postulate RNA polymerase II then transfers from the 3′ IgH enhancers to the cyclin D1 promoter and initiates cyclin D1 transcription.
Effect of phase shifting on self-imaging in optical multi-mode interference devices

Optical waveguide structures such as Multimode inference (MMI) structures, Y-connectors, splitters, couplers, multiplexers, switches and combiners are widely used for different applications. In this paper, we demonstrate the analytical analysis of effect of phase shifting in multimode inference devices, based on self imaging. This paper shows how self images changes when we introduce phase shift in the phase of input waveguide.
Measuring the fitness of fitness trackers

Data collected by fitness trackers could play an important role in improving the health and well-being of the individuals who wear them. Many insurance companies even offer monetary rewards to participants who meet certain steps or calorie goals. However, in order for it to be useful, the collected data must be accurate and also reflect real-world performance. While previous studies have compared step counts data in controlled laboratory environments for limited periods of time, few studies have been done to measure performance over longer periods of time, while the subject does real-world activities. There are also few direct comparisons of a range of health indicators on different fitness tracking devices. In this study, we compared step counts, calories burned, and miles travelled data collected by three pairs of fitness trackers over a 14-day time period in free-living conditions. Our work indicates that the number of steps reported by different devices worn simultaneously could vary as much as 26%. At the same time, the variations seen in distance travelled, based on the step count, followed the same trends. Little correlation was found between the number of calories burned and the variations seen in the step count across multiple devices. Our results demonstrate that the reporting of health indicators, such as calories burned and miles travelled, are heavily dependent on the device itself, as well as the manufacturer's proprietary algorithm to calculate or infer such data. As a result, it is difficult to use such measurements as an accurate predictor of health outcomes, or to develop a consistent criteria to rate the performance of such devices in head-to-head comparisons.
Communication and Inference of Intended Movement Direction during Human–Human Physical Interaction

Of particular interest to the neuroscience and robotics communities is the understanding of how two humans could physically collaborate to perform motor tasks such as holding a tool or moving it across locations. When two humans physically interact with each other, sensory consequences and motor outcomes are not entirely predictable as they also depend on the other agent’s actions. The sensory mechanisms involved in physical interactions are not well understood. The present study was designed (1) to quantify human-human physical interactions where one agent (“follower”) has to infer the intended or imagined – but not executed - direction of motion of another agent (“leader”), and (2) to reveal the underlying strategies used by the dyad. This study also aimed at verifying the extent to which visual feedback is necessary for communicating intended movement direction. We found that the control of leader on the relationship between force and motion was a critical factor in conveying his/her intended movement direction to the follower regardless of visual feedback of the grasped handle or the arms. Interestingly, the dyad’s ability to communicate and infer movement direction with significant accuracy improved (>83%) after a relatively short amount of practice. These results indicate that the relationship between force and motion (interpreting as arm impedance modulation) may represent an important means for communicating intended movement direction between biological agents, as indicated by the modulation of this relationship to intended direction. Ongoing work is investigating the application of the present findings to optimize communication of high-level movement goals during physical interactions between biological and non-biological agents.
Systematic Study of Highly Asymmetric Systems Using π 0 , h ± and ϕ Production at PHENIX

Abstract The observation of long range correlations in highly asymmetric systems, as in p +Pband d +Aucollisions, suggests a creation of a medium with collective behavior. Furthermore, hints of gluon saturation effects have been observed at forward rapidities in d +Aucollisions at RHIC. Single particle production has proven to be a valuable tool to probe the quark-gluon plasma in heavy-ion collisions as it is sensitive to energy loss, modifications of the nuclear wave function, and the dynamics of the projectile wave function. In order to systematically study these highly asymmetric collisions, RHIC provided beams for p +Al, p +Au, d +Auand 3 He+Aucollisions. We present the new measurements of π 0 at mid-rapidity ( | η | 0.35 ) in p +Auand 3 He+Aucollisions at s N N = 200 GeV ; and the charged hadron and ϕ production in forward ( 1.2 η 2.4 ) and backward ( − 2.2 η − 1.2 ) rapidities in p +Al, p +Auand 3 He+Aucollisions at s N N = 200 GeV .
Hip and Femur/Femoral Shaft

This chapter deals with injuries of the hip and femur. Various types of fractures and other injuries are presented. MR is discussed where it significantly adds to evaluation of these injuries.
Randomized Controlled Trial of Acupuncture for Women with Fibromyalgia: Group Acupuncture with Traditional Chinese Medicine Diagnosis-Based Point Selection.

Background Group acupuncture is a growing and cost-effective method for delivering acupuncture in the United States and is the practice model in China. However, group acupuncture has not been tested in a research setting. Objective To test the treatment effect of group acupuncture vs group education in persons with fibromyalgia. Design Random allocation two-group study with repeated measures. Setting Group clinic in an academic health center in Portland, Oregon. Subjects Women with confirmed diagnosis of fibromyalgia (American College of Radiology 1990 criteria) and moderate to severe pain levels. Methods Twenty treatments of a manualized acupuncture treatment based on Traditional Chinese Medicine diagnosis or group education over 10 weeks (both 900 minutes total). Weekly Revised Fibromyalgia Impact Questionnaire (FIQR) and Global Fatigue Index at baseline, five weeks, and 10 weeks and a four-week follow-up were assessed. Results Thirty women were recruited, with 78% reporting symptoms for longer than 10 years. The mean attendance was 810 minutes for acupuncture and 861 minutes for education. FIQR total, FIQR pain, and Global Fatigue Index all had clinically and statistically significant improvement in the group receiving acupuncture at end of treatment and four weeks post-treatment but not in participants receiving group education between groups. Conclusions Compared with education, group acupuncture improved global symptom impact, pain, and fatigue. Furthermore, it was a safe and well-tolerated treatment option, improving a broader proportion of patients than current pharmaceutical options.
Hydrodynamic flows on curved surfaces: Spectral numerical methods for radial manifold shapes

Abstract We formulate hydrodynamic equations and spectrally accurate numerical methods for investigating the role of geometry in flows within two-dimensional fluid interfaces. To achieve numerical approximations having high precision and level of symmetry for radial manifold shapes, we develop spectral Galerkin methods based on hyperinterpolation with Lebedev quadratures for L 2 -projection to spherical harmonics. We demonstrate our methods by investigating hydrodynamic responses as the surface geometry is varied. Relative to the case of a sphere, we find significant changes can occur in the observed hydrodynamic flow responses as exhibited by quantitative and topological transitions in the structure of the flow. We present numerical results based on the Rayleigh-Dissipation principle to gain further insights into these flow responses. We investigate the roles played by the geometry especially concerning the positive and negative Gaussian curvature of the interface. We provide general approaches for taking geometric effects into account for investigations of hydrodynamic phenomena within curved fluid interfaces.
Tutorial: data stream mining and its applications

Data streams are continuous flows of data. Examples of data streams include network traffic, sensor data, call center records and so on. Their sheer volume and speed pose a great challenge for the data mining community to mine them. Data streams demonstrate several unique properties: infinite length, concept-drift, concept-evolution, feature-evolution and limited labeled data. Concept-drift occurs in data streams when the underlying concept of data changes over time. Concept-evolution occurs when new classes evolve in streams. Feature-evolution occurs when feature set varies with time in data streams. Data streams also suffer from scarcity of labeled data since it is not possible to manually label all the data points in the stream. Each of these properties adds a challenge to data stream mining. Multi-step methodologies and techniques, and multi-scan algorithms, suitable for knowledge discovery and data mining, cannot be readily applied to data streams. This is due to well-known limitations such as bounded memory, high speed data arrival, online/timely data processing, and need for one-pass techniques (i.e., forgotten raw data) issues etc. In spite of the success and extensive studies of stream mining techniques, there is no single tutorial dedicated to a unified study of the new challenges introduced by evolving stream data like change detection, novelty detection, and feature evolution. This tutorial presents an organized picture on how to handle various data mining techniques in data streams: in particular, how to handle classification and clustering in evolving data streams by addressing these challenges. The importance and significance of research in data stream mining has been manifested in most recent launch of large scale stream processing prototype in many important application areas. In the same time, commercialization of streams (e.g., IBM InfoSphere streams, etc.) brings new challenge and research opportunities to the Data Mining (DM) community. In this tutorial a number of applications of stream mining will be presented such as adaptive malicious code detection, on-line malicious URL detection, evolving insider threat detection and textual stream classification.
von Willebrand factor as a target for antithrombotic intervention.

The adhesive protein von Willebrand factor (vWF) is essential for the formation of platelet thrombi under flow conditions characterized by high shear stress. Two distinct platelet receptors, the glycoprotein (GP) complexes Ib-IX-V and Ilb-IIIa, are required for these interactions. Interaction with GP Ib-IX-V results in platelet activation, a necessary step for binding to GP Ilb-IIIa and stable aggregation. Inhibition of von Willebrand factor binding to GP Ib can be achieved with small recombinant fragments containing the specific functional domain of the von Willebrand factor molecule that interacts with this platelet receptor. Such fragments may provide a new selective approach to antithrombotic therapy.
Using Energy Dispersive X-Ray Measurements for Quantitative Determination of Material Loss Due to Corrosion

Corrosion is a general term for the oxidation process of metal. In the case of aircraft, corrosion on aluminum airframe skin can often be recognized by dulling or pitting of an area, and sometimes by the white powdery deposit of aluminum corrosion product. Corrosion in these areas means loss of aluminum material from the airframe skin. Thus corrosion can seriously affect the structural integrity of an aircraft unless proper inspection and maintenance is systematically performed. During heavy structural aircraft maintenance, corrosions are still defined mostly in a qualitative rather than a quantitative sense. The qualitative evaluations are biased and unpredictable because corrosions are extremely hard to detect and to predict in their early stages of formation.
Cydnocoris Stål, 1866 (Insecta: Heteroptera: Reduviidae): a junior synonym of Cutocoris Stål, 1859.

The purpose of this note is to review the usage of the generic names Cutocoris Stal, 1859 and Cydnocoris Stal, 1866 (type species: Myocoris gilvus Burmeister, 1838) for a genus of harpactorine assassin bugs from the Oriental Region, the latter being an unnecessary replacement name proposed for the former. Although Cutocoris Stal, 1859 has been used rarely since its replacement and Cydnocoris is undoubtedly in prevailing usage, it is demonstrated that neither name has been used extensively in the last century; thus, the case for suppression of Cutocoris Stal, 1859 lacks strong support. As a consequence, Cydnocoris Stal, 1866 is replaced by its senior synonym, Cutocoris Stal, 1859.
Verifying Asynchronous Event-Driven Programs Using Partial Abstract Transformers

We address the problem of analyzing asynchronous event-driven programs, in which concurrent agents communicate via unbounded message queues. The safety verification problem for such programs is undecidable. We present in this paper a technique that combines queue-bounded exploration with a convergence test: if the sequence of certain abstractions of the reachable states, for increasing queue bounds k, converges, we can prove any property of the program that is preserved by the abstraction. If the abstract state space is finite, convergence is guaranteed; the challenge is to catch the point \(k_{\max }\) where it happens. We further demonstrate how simple invariants formulated over the concrete domain can be used to eliminate spurious abstract states, which otherwise prevent the sequence from converging. We have implemented our technique for the P programming language for event-driven programs. We show experimentally that the sequence of abstractions often converges fully automatically, in hard cases with minimal designer support in the form of sequentially provable invariants, and that this happens for a value of \(k_{\max }\) small enough to allow the method to succeed in practice.
Comparison of Mental Workload and Available Capacity in Complex Person-Machine Systems

Abstract A method is described for building intelligent person-system interfaces which are responsive to changes in task demand. This approach uses on-line mental workload (MWL) assessment procedures which are comprised of both physiological and performance measures. Comparison of available perceptual and cognitive capacity with the current level of MWL demanded of the operator by the task activates a compensatory procedure that shifts the processing load toward or away from the human in order to optimize overall system performance. This procedure is dependent on the derivation of the error signal which is input into the compensatory system element. The overall success of the intelligent interface relies largely on the validity and accuracy of this error signal. The error signal is based on a fuzzy set-theoretic formulation. A multivariate profile of physiological responses and measures of primary task performance are mapped onto two fuzzy sets. A fuzzy discriminating criterion, related to the fuzzy cluster-analytic model, is used in assigning the membership functions for each of two MWL categories. The resources required by the task are specified in terms of set membership functions for each attentional resource. This information is combined into an error signal used in subsequent dynamic task reallocation.
Pseudoreplication bias in single-cell studies; a practical solution

Cells from the same individual share a common genetic and environmental background and are not independent, therefore they are subsamples or pseudoreplicates. Empirically, we show this dependence across a range of cell types. Thus, single-cell data have a hierarchical structure that current single-cell methods do not address and subsequently the application of such tools leads to biased inference and reduced robustness and reproducibility. When properly simulating the hierarchical structure of single-cell data, commonly applied single-cell differential expression analysis tools exhibit highly inflated type I error rates, particularly when applied together with a batch effect correction for individual as a means of accounting for within sample correlation. As single-cell experiments increase in size and frequency, we propose applying generalized linear mixed models that include random effects for differences among persons to properly account for the correlation structure that exists among measures from cells within an individual.
Nurse Driven CVC Rounding Utilized to Improve Bone Marrow Transplant Patient Outcomes

Topic Significance & Study Purpose/Background/Rationale Central venous catheters (CVC) are frequently used in Bone Marrow Transplant (BMT) patients. BMT RNs are responsible for the care of CVC during a patient's hospitalization. CVC require dressing changes, needless connector changes, and frequent line entries. Patients with a CVC are at risk for acquiring a catheter line associated bloodstream infection (CLABSI). Due to BMT patients having compromised immune systems and altered gut integrity, the risk for acquiring a CLABSI is exponentially higher. Methods, Intervention, & Analysis A nurse led BMT unit based team was formed which became known as BMT CVC Representatives. CVC Representatives function as resources for team members, patients, and families. A CVC Representative rounds weekly on all patients on the BMT unit. Along with assessing the status of CVC dressings, activities include monitoring chlorhexidine (CHG) bathing (including education on CHG bathing to team members, patients, and families), monitoring passive disinfection devices, identifying patients with potential for CLABSI and assisting in crafting interventions for CLABSI prevention, mitigating potential CVC complications, and participating in CLABSI huddles. Findings & Interpretation BMT CVC Representatives are able to foster frontline engagement and identification of interventions that align with the goal to delivering exceptional and safe care. The interventions practiced at the bedside are critical to the patients' overall health and achievement of quality outcomes. The team is able to collaborate in mitigating patient specific solutions when dealing with challenging CVC care situations. BMT CLABSI infection rate continues to be a focus with the CLABSI rate at 2.00 BSI per 1,000 catheter line days at the end of fiscal year 2019 as compared to 2.65 BSI per 1,000 catheter line days at the end of fiscal year 2018. Discussion & Implications There has been an increase in awareness of CVC care which directly effects the BMT patient's health and outcomes. With weekly rounds the BMT CVC Representatives are able to be a resource for the team, patients, and families. They are a constant advocate for CHG bathing and other CLABSI prevention interventions.
Modeling Health Coaching Dialogues for Behavioral Goal Extraction

In this paper, we will discuss our framework for summarizing goals discussed during health coaching dialogues. This can help coaches to recall patients' goals without reading the conversations. We build two supervised classification models, one for extracting the slot-values (goal attributes) and another to model the dialogue flow (stages-phases) of the conversation. Using these two models and heuristics, we build our goal extraction pipeline.