cssi/SciSciGPT-SciSciNet huggingface dataset:
Fetal Hydrops Secondary to in utero Pancytopenia

Nonimmune hydrops remains a challenge in the prenatal setting with many cases not having a clear etiology determined prior to birth. We present an unusual case of one fetus of a dichorionic twin pair presenting at 24 weeks' gestation with hydrops and fetal pancytopenia with complete absence of white cells of unknown etiology, as revealed by cordocentesis. Serial red blood cell transfusions resulted in resolution of hydrops and continuation of the pregnancy until 35 weeks' gestation. Pancytopenia was noted throughout gestation and persisted in the newborn period. Moreover, the T-cell receptor excision circle (TREC) assay, a newborn screening test for severe T-cell deficiency, was abnormal at birth. Further evaluation revealed detectable TRECs and normal response to lymphocyte mitogens indicating some preserved thymic and lymphocyte function. The affected child had spontaneous resolution of the pancytopenia, including her severe T-cell deficiency, by 10 weeks of life. There has been no recurrence as of 24 months of age. The self-resolving nature of the pancytopenia is an important feature of this case of nonimmune hydrops. The abnormal TREC assay at birth in the affected infant may help explain the discordant prenatal findings.
Case Studies and Transcendent Children

The influential case study tradition initiated by the Chicago School (Thomas and Znaniecki, W. I. Thomas, and Shaw; modified by Lindesmith and Cressey) has languished of late. Recent developments, narrative analysis, standpoint theory, and analyses of textual voice (Hertz 1997), perhaps obscure the known virtues of case analysis. A well analyzed and constructed case connects selves and social structure and when integrated in a mosaic of studies, integrates social and ecological processes with life experiences that illuminate collective action (Becker 1966). The role of case studies in theorizing remains a lively question (Becker and Ragin 1992). This, the latest book of Lillian Rubin, contains lively case material that raises issues central to qualitative research. Lillian Rubin, a sociologist and therapist, author of challenging books tracing the imprints of social structure on individual development and family life (1976, 1994), has written a book well balanced between trade and academic markets. The Transcendent Child, constituted of eight brief case studies (of around 25 pages) asks how children "transcend" dysfunctional families. This theme shifts attention from failure and victimization to coping and achievement. The case studies illustrate the effects of race, class, and gender differences on socialization—a wealthy white woman; a woman of Mexican immigrant parents; a black man raised in a project in Chicago; a man and
Single-Port Robot-Assisted Radical Prostatectomy: First Clinical Experience Using The SP Surgical System.

Abstract Objectives To describe the first clinical experience with the novel purpose-built single-port robotic platform after Food Drug Administration approval. Methods Two male patients diagnosed with prostate cancer amenable of radical prostatectomy underwent single-port robot-assisted radical prostatectomy with bilateral pelvic lymph-nodes dissection performed by using the da Vinci SP Surgical System (Intuitive Surgical, Sunnyvale, CA). The surgeries were completed through a 2.5-cm periumbilical incision through which a GelPOINT Mini advanced access platform (Applied Medical, Rancho Santa Margarita, CA) and the dedicated 25-mm multichannel port accommodating a 12 × 10 mm oval articulating robotic camera, three 6-mm double-jointed articulating robotic instruments and a 6-mm accessory laparoscopic instrument were placed. One port for the assistant was placed at the level of the para-rectal line, at the planned final site for the drainage. The primary aim was to report, for the first time in the United States after Food Drug Administration approval of the system, the technical feasibility in the living human. The secondary aim was to report the perioperative outcomes. Results The surgeries were successfully completed without conversion. In both cases, the total operative time was 140 minutes. Blood loss was negligible. No complications were recorded. Patients were discharged within 24 hours postoperation. Conclusions Herein, we documented the first clinical application of the SP surgical platform for single-port transumbilical robot-assisted radical prostatectomy in the United States. This approach will be further investigated regarding the surgical morbidity and the outcomes.
Prospective Evaluation of Internalized Weight Bias and Weight Change Among Successful Weight‐Loss Maintainers

OBJECTIVE Internalized weight bias (IWB) has been associated with weight regain after intentional weight loss, but reliance on cross-sectional data limits the understanding of this relationship. This study prospectively evaluated IWB as a predictor of weight change in a longitudinal observational study of successful weight-loss maintainers. METHODS National Weight Control Registry participants (maintained 13.6-kg weight loss for ≥ 1 y) were asked to complete an online questionnaire including current weight and Weight Bias Internalization Scale-Modified (WBIS-M) at baseline and 12 months. RESULTS At baseline, 1,250 of 1,643 eligible individuals completed the baseline assessment (71% female; 94% white; mean age ± SD: 52 y ± 13.1; BMI: 27 ± 5.5). The average WBIS-M score was 3.0 (± 1.3). Study completers (n = 862) reported 2.2% (± 7.8%) weight gain. Higher baseline IWB predicted weight gain among men (n = 254; t = -2.28; P = 0.02) but not women (n = 608; t = 1.22; P = 0.22). A one-point reduction in WBIS-M score at follow-up was associated with a 3.0% weight loss. CONCLUSIONS Among weight-loss maintainers, IWB may be a risk factor for weight gain among men. Weight loss at follow-up was associated with reduced IWB in both men and women. Reliance on female-only samples may limit our understanding of IWB and its implications for weight control.
Allergy Testing and Immunotherapy

1. Alanna G. Wong, MD*,† 2. Jeanne M. Lomas, DO*,† 1. *Division of Pediatric Allergy/Immunology, Golisano Children’s Hospital at Strong, Rochester, NY 2. †Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY * Abbreviations: EoE: : eosinophilic esophagitis FDA: : Food and Drug Administration IDT: : intradermal testing IgE: : immunoglobulin E SCIT: : subcutaneous immunotherapy SLIT: : sublingual immunotherapy SPT: : skin prick testing General pediatricians should be aware of currently available options for both allergy testing and treatment of allergic disease, including immunotherapy. These are areas that practitioners may have limited exposure to during pediatric training and beyond, thus there are misconceptions about the evaluation and management of various allergic conditions. After completing this article, readers should be able to: 1. Understand when allergy testing is indicated and the different methods used. 2. Recognize what conditions can be treated with allergy immunotherapy and the different modalities currently available for pediatric patients. Atopic diseases in the pediatric population often become a source of major concern for both patients and their caretakers. These conditions are quite common in children, with 5.6% having reported food allergies, 9% with hay fever, 11% with respiratory allergies, and 12% with skin allergies based on the 2012 National Health Interview Survey of US children. (1) Allergies are generally chronic and can significantly affect the child’s quality of life. For …
Relation of the Organization to the Outside World

Ever since the “bold new approach” (1963) launched by President Kennedy with the support of the American Psychiatric Association, the National Institute of Mental Health, and numerous other organizations, we have become increasingly conscious of the larger community in which mental health service organizations are imbedded and on which they depend for their viability and success.
Past, Present, and Future: A Look at How CEO Temporal Focus Affects Strategic Risk Taking

This study advances the behavioral agency model (BAM) by demonstrating that agents’ temporal focus can shape the influence of their option incentives on strategic risk taking. Specifically, we argu...
Skin Microcolumns as a Source of Paracrine Signaling Factors.

Objective: We recently developed the approach of using “microcolumns” of autologous full-thickness skin tissue for wound repair. The small size of these micro skin tissue columns (MSTCs, ∼0.5 mm in...
Multiplet effects in the quasiparticle band structure of the f1-f2 Anderson model.

In this paper, we examine the mean-field electronic structure of the [ital f][sup 1][minus][ital f][sup 2] Anderson lattice model in a slave-boson approximation, which should be useful in understanding the physics of correlated metals with more than one [ital f] electron per site such as uranium-based heavy-fermion superconductors. We find that the multiplet structure of the [ital f][sup 2] ion acts to quench the crystal-field splitting in the quasiparticle electronic structure. This is consistent with experimental observations in such metals as UPt[sub 3].
The effect of farmers’ market access on residential property values

Abstract Improving farmers' market accessibility is increasingly being used as a mechanism to promote healthy food consumption. Previous studies about farmers’ markets largely focused on describing either the demographics of market patrons or the impact of market participation on fruit and vegetable intake. Thus, little empirical research has examined how market accessibility impacts nearby communities. The goal of this study is to assess whether consumers value farmers' market accessibility by exploiting preferences revealed through housing purchases. Using residential sales data from 2007 to 2012 in five Central Maryland counties, we tested whether farmers' market accessibility is associated with housing prices by estimating hedonic models with temporal and neighborhood fixed effects. The results suggest an inverse association between housing prices and distance to the closest farmers’ market, a relationship that remains statistically significant when using matching and instrumental variables estimators. The results also suggest that the association between market accessibility and housing prices is stronger in areas with poor-quality food environments. The findings are important to policy makers and planners because they suggest that farmers' market accessibility is valued by consumers in nearby communities and that consumers with limited access to food stores are willing to pay a premium for houses with access to farmers’ markets. Assessing the mechanisms driving this association is an important area for future research.
THE MELT REFINING OF IRRADIATED URANIUM: APPLICATION TO EBR-II FAST REACTOR FUEL. III. PREPARATION OF EXPERIMENTAL ALLOYS

A complex alloy of uranium with zirconium, niobium, molybdenum, ruthenium, and palladium ( uranium-fissium) was prepared by induction co-melting and casting. Alloying with plutonium and cerium was also studied. Good recoveries of the alloying elements in homogeneous ingots was achieved. The techniques established by this study are being used to prepare the core material for EBR-II. (auth)
Mutational profiling of micro-dissected pre-malignant lesions from archived specimens

Systematic cancer screening has led to the increased detection of pre-malignant lesions (PMLs). The absence of reliable prognostic markers has led mostly to over treatment resulting in potentially unnecessary stress, or insufficient treatment and avoidable progression. Importantly, most mutational profiling studies have relied on PML synchronous to invasive cancer, or performed in patients without outcome information, hence limiting their utility for biomarker discovery. The limitations in comprehensive mutational profiling of PMLs are in large part due to the significant technical and methodological challenges: most PML specimens are small, fixed in formalin and paraffin embedded (FFPE) and lack matching normal DNA. Using test DNA from a highly degraded FFPE specimen, multiple targeted sequencing approaches were evaluated, varying DNA input amount (3–200 ng), library preparation strategy (BE: Blunt-End, SS: Single-Strand, AT: A-Tailing) and target size (whole exome vs. cancer gene panel). Variants in high-input DNA from FFPE and mirrored frozen specimens were used for PML-specific variant calling training and testing, respectively. The resulting approach was applied to profile and compare multiple regions micro-dissected (mean area 5 mm2) from 3 breast ductal carcinoma in situ (DCIS). Using low-input FFPE DNA, BE and SS libraries resulted in 4.9 and 3.7 increase over AT libraries in the fraction of whole exome covered at 20x (BE:87%, SS:63%, AT:17%). Compared to high-confidence somatic mutations from frozen specimens, PML-specific variant filtering increased recall (BE:85%, SS:80%, AT:75%) and precision (BE:93%, SS:91%, AT:84%) to levels expected from sampling variation. Copy number alterations were consistent across all tested approaches and only impacted by the design of the capture probe-set. Applied to DNA extracted from 9 micro-dissected regions (8 PML, 1 normal epithelium), the approach achieved comparable performance, illustrated the data adequacy to identify candidate driver events (GATA3 mutations, ERBB2 or FGFR1 gains, TP53 loss) and measure intra-lesion genetic heterogeneity. Alternate experimental and analytical strategies increased the accuracy of DNA sequencing from archived micro-dissected PML regions, supporting the deeper molecular characterization of early cancer lesions and achieving a critical milestone in the development of biology-informed prognostic markers and precision chemo-prevention strategies.
Urine Microscopy for Internal Medicine Residents: A Needs Assessment and Implementation of Virtual Teaching Sessions

Background Although urine microscopy is an important step in the initial evaluation of a patient with kidney disease, internal medicine residents have minimal exposure to this technique during their training. The goal of this study was to understand knowledge of and attitudes toward urine microscopy among internal medicine residents and to implement virtual urine microscopy teaching sessions. Methods A voluntary, anonymous, online survey was sent to all of the categorical internal medicine residents (n=131) training at the Icahn School of Medicine at Mount Sinai (ISMMS). The survey included 13 questions to assess attitudes toward, experience with, and clinical interpretation of urine microscopy specimens. In response to the survey results, we implemented virtual urine microscopy teaching sessions using video conferencing software that incorporated real-time urine sediment analysis with nephrology fellows and attending nephrologists. Results The survey response rate was 45% (59 of 131). Forty-seven percent (28 of 59) of respondents reported performing urine microscopy at least once during their training, and 75% (44 of 59) of respondents did not feel comfortable performing urine microscopy. The majority of residents (92%; 54 of 59) reported they felt urine microscopy was very helpful or somewhat helpful in the evaluation of patients with AKI. Overall, 41% of responses to clinical interpretation questions were considered correct. Following survey completion, virtual urine microscopy sessions were held monthly and well received by the participants. Conclusions Our study found that internal medicine residents perceive urine microscopy as a helpful diagnostic tool, although lack the skills to perform and interpret urine microscopy sediments. Virtual educational sessions using video conferencing software are a technically feasible approach to teaching urine microscopy to internal medicine residents. Future studies include a study of the effect of these sessions on learning of urine microscopy. Podcast This article contains a podcast at https://www.asn-online.org/media/podcast/K360/2021_01_28_KID0006282020.mp3.
Macros for domain-specific languages

Macros provide a powerful means of extending languages. They have proven useful in both general-purpose and domain-specific programming contexts. This paper presents an architecture for implementing macro-extensible DSLs on top of macro-extensible host languages. The macro expanders of these DSLs inherit the syntax system, hygienic expansion, and more from the host. They transform the extensible DSL syntax into a DSL core language. This arrangement has several important consequences. It becomes straightforward to integrate the syntax of various DSLs and the host language when their expanders share these inherited components. Also, a DSL compiler may be designed around a fixed core language, even for an extensible DSL. Finally, macros empower programmers to safely grow DSLs on their own and tailor them to their needs.
The everyday traumas of neoliberalism in women teachers’ bodies: Lived experiences of the teacher who is never good enough:

A teacher’s ability to feel successful – some might even say good – in today’s education system relies on a particular conception of academic success. We argue neoliberalism, as it operates in educ...
Cloud Computing and Covid-19

At present the spread of Covid-19 (Coronavirus disease) has become a major threat to human health. Covid-19 is a deadly disease and it is the main reason behind many heath causalities all over the world as it’s hard to detect and even harder to contain. Every nation has taken serious measures to control the spread of the disease. In the fight against the Coronavirus, the modern-day technologies play an extraordinary role. The technologies mitigate the effects of Coronavirus up to great extent. The technologies such as artificial intelligence (AI), Cloud computing, Internet of things (IoT), Sensor technologies, Robotics etc., contributes a lot to mitigate the effects. Out of these technologies, the Cloud computing and storage stands one step ahead in its contribution. The Cloud services are used to store, monitor, predict and analyze the huge set of patient’s data. This translates the tedious task of data processing into relatively easy one and helps mankind.
Designing inclusive community-based geography research experiences across the spectrum of ability

Through the voices of both faculty and student authors, we discuss the intentional integration of neurodiversity in an undergraduate, community geography research program. This exploratory case stu...
Foreign-accented sentence comprehension is challenging for older adults: ERP evidence from semantic and grammar processing

Abstract Research has shown that older adults have increased difficulty comprehending foreign-accented speech. As these studies have only used behavioral measures, we exploited the fine-grained temporal resolution of EEG/ERPs to examine neural signatures of foreign- and native-accented sentence comprehension in older adults. Older adults, all normal-hearing monolingual English speakers, listened to foreign Chinese-accented and native English-accented sentences while ERPs were recorded. Foreign- and native-accented sentences contained semantic or pronoun errors, or were semantically and grammatically correct. We also gathered behavioral measures of sentence comprehension, and examined how neural activity during sentence processing relates to individual differences in listeners’ attitudes towards accented speakers, linguistic and cognitive skills, and hearing acuity. Older adults showed high comprehension accuracy of both foreign-accented and native-accented sentences. In contrast, ERP data showed different neural responses to foreign- and native-accented sentences: Semantic errors elicited an N400 effect in native-accented sentences, but not in foreign-accented sentences. Grammatical errors elicited a P600, not further qualified by accent type. Hearing acuity and individual differences in language attitudes, cognitive and linguistic variables did not systematically correlate with ERP patterns. These findings suggest that older adults are ultimately engaging in foreign-accented sentence comprehension, but non-native pre-lexical speech signals do not attain activation needed for strong lexical activation during online processing, resulting in strained and more effortful higher-level processing of semantics downstream the sentence.
Measuring Structural Racism: A guide for epidemiologists and other health researchers

There have been over one hundred years of literature discussing the deleterious influence of racism on health. Much of the literature describes racism as a driver of social determinants of health such as housing, employment, income, and education. More recently, increased attention has been given to measuring the structural nature of a system that advantages one racialized group over others rather than solely relying on individual acknowledgement of racism. Despite these advances, there is still a need for methodological and analytical approaches to complement the aforementioned. This commentary calls on epidemiologists and other health researchers at-large to engage the discourse on measuring structural racism. First, we address the conflation between race and racism in epidemiological research. Next, we offer methodological recommendations (linking of interdisciplinary variables and datasets and leveraging mixed-method and life course approaches) and analytical recommendations (integration of mixed data, use of multidimensional models) that epidemiologists and other health researchers may consider in health equity research. The goal of this commentary is to inspire the use of up-to-date and theoretically-driven approaches to increase discourse amongst public health researchers on capturing racism as well as to improve evidence of its role as the fundamental cause of racial health inequities.
A Constructivist Approach to Web Course Design, A Review of the Literature

I 1996, the National Survey of Desktop Computing in Higher Education reported that assisting faculty in course design and integrating it into the curriculum as the single most important issue facing institutions of higher learning (Green, 1996). This was five years ago, and it is still an issue today. In fact, the report issued in October of 2001 reiterates this same concern. It is still the single most important issue facing campuses across the nation and will be for the next two or three years (Green, 2001). To assist faculty in coping with this dilemma, Instructional Technology Centers (ITCs) have emerged as integral departments on most college campuses (Carr-Chellman & Duchastel, 2000, p.233). Employees in these departments are scrambling to help faculty keep current with the rapidly changing technology. Design pedagogy is a major concern (Dick, 1996; Mioduser, Nachmias, Lahav, & Oren, 2000). However, within the literature, there are limited empirical studies geared toward analyzing effective pedagogy for online courses. Faculty members reluctance to have their courses scrutinized could be attributed to this. Most likely, it is because teaching methodology has been thoroughly analyzed in traditional classrooms, and the hypothesis is that the same pedagogy should exist in web courses. Nonetheless, a recent study at Brevard College in North Carolina accentuates that lecturing is still the most often utilized method of learning (Newman & Scurry, 2001, p. 7). This passive learning technique is not aligned with current pedagogy. Ross and Schulz (1999), in their article A Constructivist Approach to Web Course Design: A Review of the Literature
Identification and grouping of mycoplasmalike organisms associated with grapevine yellows and clover phyllody diseases based on immunological and molecular analyses

Immunofluorescent staining, dot blot hybridization, PCR, random amplified polymorphic DNA (RAPD) markers, and restriction fragment length polymorphism wee used to study the genetic relatedness among mycoplasmalike organisms (MLOs) associated with several geographically diverse grapevine yellows diseases (CA1, CH1, SA1, and SA2 from Bologna, Italy; GYU from Udine, Italy; GYR from Rome, Italy; and GYG from Germany). The relationship between these and MLOs associated with clover phyllody diseases in Italy (CPhB and CPhC) and Canada (CPhCa) was also examined. Two monoclonal antibodies reacted with MLOs of GYU-, CPhB-, and CPhC-infected periwinkles. Dot blot hybridization with two cloned GYU DNA fragments, GYD-1 and GYD-2 inserts, showed that both hybridized with DNAs of GYU-, CPhB-, and CPhC-infected periwinkles but not with those of GYR and CPhCa. In addition, GYD-1 insert hybridized with DNAs of CA1, CH1, SA1, SA2, and GYG. Three primer pairs were developed in PCR experiments for this study. By using primer set GYD2P1F and GYD2P1R, a 600-bp DNA fragment was amplified only when DNAs from GYU-, CPhB-, and CPhC-infected plants were used as templates. With the primer pair GYD2P1F and GYD2P2R, a 550-bp DNA fragment was amplified from GYU, CPhB, CPhC, and GYG. The primer pair GYD1P1F and GYD1P2R, on the other hand, could amplify all isolates, although the patterns of PCR products were not identical for all isolates.(ABSTRACT TRUNCATED AT 250 WORDS) Images
Is Anti-Semitism Unique?: Review of Clemens Heni, Antisemitism: A Specific Phenomenon (Berlin: Edition Critic, 2013)

Is Anti-Semitism a discrete, specific and unique phenomenon or merely a particular instance of a broader social pathology such as xenophobia or racism? This question has proven surprisingly controversial among scholars of contemporary anti-Semitism. The latest intervention in this debate has been German political scientist Clemens Heni's massive volume, Antisemitism: A Specific Phenomenon (Berlin: Edition Critic 2013). This review essay places Heni's work in a historical and theoretical perspective, explaining the context, politics and stakes involved in this debate. The essay is part of the author's broader research project on "The Definition of Anti-Semitism," which will culminate in a book-length analysis in 2014.
Making sense of prototyping technologies for product design

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, and Sloan School of Management, 1991.
EFFECT OF A RETENTION INTERVAL ON RECALL OF PRESENTATION MODE

Summary.-Using photographs and words, 6 instances of each of G taxonomic categories were presented under incidental learning conditions to 48 college students. Either 3 min. or 1 wk. after seeing the items, the students were unexpectedly asked to free-recall the items and further to recall the presentation mode of each, i.e., whether it had been presented as a photograph or as a written word. The results showed that, for recalled items, recollection of presentation mode was better before the 1-wk. retention interval than after it and better following photographic than verbal presentation. In fact, after the 1-wk. retention interval, presentation mode of items presented as written words was recollected incorrectly as often as correctly even if the content of the items was correctly recalled. Underwood (1969) hypothesized that modality attributes of stimuli are stored and that they are probably used in deciding whether an item under consideration was or was not presented. There is evidence that soon after item presentation, modality attributes are available and could be used to help distinguish between presented and non-presented items (Light, Stansbury, Rubin, & Linde, 1973). However, whether this would still be true after a substantial retention interval was unknown. Yet this information is of interest, because the degree of available detail of a presentation has implications for the generation and application of experiential knowledge (Posner, 1973), including knowledge gained from educational materials. Moreover, there was a lack of data concerning the degree of generalizability over retention intervals of results obtained soon after item presentation. Consequently, the present study investigated the effect of a retention interval on the storage of modality attributes of stimuli. Specifically, since pictorial presentation usually leads to better recall of the items represented than does presentation by written words (Paivio, 1969), it was hypothesized that recall of presentation mode is more accurate following pictorial presentation, both before and after a 1-wk. retention interval. Furthermore, accuracy of recall of presentation mode should decrease with time. It is the degree of this decrease which has implications for the significance of retention intervals, both for generalizing from results obtained soon after item presentation and for the need to study the effects of varying durations of time following presentations in future research.
Effects of raffinose on sucrose crystal growth kinetics and rate dispersion

Etude effectuee par mesures de l'elargissement de la distribution dimensionnelle de cristaux germes obtenus en suspension et par mesures photomicroscopiques directes de la croissance de ces cristaux germes. Domaine de sursaturation etudie: 0,28 a 2,05 g de sucrose pour 100 g de solution, entre 313 et 333 K
Group III human metabotropic glutamate receptors 4, 7 and 8: Molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

Cloning and expression in a stable mammalian cell line co-transfected with a glutamate transporter (RGT cells) were used as tools for studying the functions and pharmacological properties of group III metabotropic glutamate receptors (mGluRs). Complementary DNAs (cDNAs) encoding the human mGluR4, human mGluR7, and human mGluR8 were isolated from human cerebellum, fetal brain or retinal cDNA libraries. The human mGluR4, mGluR7 and mGluR8 receptors were 912, 915 and 908 amino acid residues long and share 67-70% amino acid similarity with each other and 42-45% similarity with the members of mGluR subgroups I and II. The human mGluR4 and mGluR7 had amino acid identity of 96% and 99.5% with rat mGluR4 and 7, respectively, whereas the human mGluR8 has 98.8% amino acid identity with the mouse mGluR8. The nucleotide and amino acid sequences in the coding region of human mGluR4 and mGluR7 were found to be identical to the previously published sequences by Flor et al. and Makoff et al. Following stable expression in RGT cells, highly significant inhibitions of forskolin stimulation of cAMP production by group III agonists were found for each receptor. The relative potencies of the group III agonist L-AP4 varied greatly between the group III clones, being mGluR8>mGluR4 >> mGluR7. The reported group II mGluR agonist L-CCG-I was a highly potent mGluR8 agonist (EC50=0.35 microM), with significant agonist activities at both mGluR4 (EC50=3.7 microM) and mGluR7 (EC50=47 microM). The antagonist potency of the purported group III mGluR antagonist MPPG also varied among the receptors being human mGluR8 >> mGluR4 = mGluR7. The expression and second messenger coupling of human group III mGluRs expressed in the RGT cell line are useful to clearly define the subtype selectivities of mGluR ligands.
PACEMAKER FAILURE ASSOCIATED WITH THERAPEUTIC RADIATION

A 48-year-old white man with a multiprogrammable Intramedics 259-01 pacemaker was treated for inoperable lung cancer with a course of cobalt-60 radiotherapy (total 3,500 rad). Several weeks subsequent to his last radiation treatment, the patient presented to the emergency department with chest and abdominal pain, shortness of breath, hypotension, and tachycardia. A paced tachycardia was noted, and application of a magnet over the pacemaker completely inhibited its function, allowing a normal sinus rhythm to ensue and the patient's symptoms to be relieved. Pacemaker failure probably was a complication of radiotherapy.
Dynamic Tensile Loading and Altered Cell Contractility Modulate Nuclear Deformation and Cytoskeletal Connectivity

Effective use of progenitor cells in orthopaedic tissue engineering will require a thorough understanding of the mechanisms by which forces are transmitted and sensed, and how these change with differentiation. Nesprins are a family of structural proteins that partially localize to the nuclear envelope where they interact with both cytoskeletal and nucleoskeletal proteins [1]. At their C-terminus, nesprins interact through a KASH domain with proteins of the nuclear membrane, including SUN and Lamin A/C [1]. Multiple isoforms of the 4 nesprin genes are produced by alternative transcriptional initiation, translation and splicing. Specifically, nesprin 1 and nesprin 2 giant contain an N-terminal calponin homology domain (CH) that binds to and co-localizes with F-actin [2]. These nesprins are necessary for transmission of stress to the nucleus and are also differentially regulated with myogenesis, neurogenesis and adipogenesis [3,4]. We previously demonstrated that addition of TGF-3 induced nuclear Lamin A/C reorganization and nuclear stiffening in mesenchymal stem cells (MSCs), along with increased cell contractility and altered accumulation of smaller nesprin isoforms [5,6]. This study sought to determine the importance of contractility in transmission of force to the nucleus and the effect of dynamic loading on the expression of the giant nesprin isoforms.Copyright © 2012 by ASME
Snowfall into a forest and clearing

Experiments in February–March 1987 at Fraser Experimental Forest in Colorado, U.S.A., compared the number flux of snow particles above the center of an 80-m wide clearing with simultaneous samples in and above the forest 85 m upwind. Numbers of snow particles counted with electronic sensors on towers decreased with decreasing height below the canopy top in the forest and also nearer the surface in the clearing. Average fluxes were greater in the clearing than in the forest, and these differences increased with increasing average wind speed, in the 0–6 m s−1 range, measured during the experiments. The greater flux at the tower in the clearing could not be completely explained by interception of snow in the forest canopy, indicating that aerodynamics may have played a part in creating the difference, even in those light winds. A plumer or concentration of snow particles appeared to have developed near the top of the canopy and spread into the clearing.
Exploratory Investigation of Perceptions of Influences on Best-Friend Relationships:

24 male and 24 female college undergraduates (aged 18 to 50 yr.) responded to close-ended and open-ended questions concerning a relationship with a male or female best friend. Subjects rated import...
Encoding domain knowledge for propositional planning

Propositional satisfiability checking is a powerful approach to domain-independent planning. In nearly all practical applications, however, there exists an abundance of domain-specific knowledge that can be used to improve the performance of a planning system. This knowledge is traditionally encoded as procedures or rules that are tied to the details of the planning engine. We present a way to encode domain knowledge in a purely declarative, algorithm independent manner. We demonstrate that the same heuristic knowledge can be used by completely different search engines, one systematic, the other using greedy local search. This approach enhances the power of planning as satisfiability : solution times for some problems are reduced from days to seconds.
Gravitational waves from inspiraling compact binaries: Parameter estimation using second-post-Newtonian waveforms.

The parameters of inspiraling compact binaries can be estimated using matched filtering of gravitational-waveform templates against the output of laser-interferometric gravitational-wave detectors. The estimates are most sensitive to the accuracy with which the phases of the template and signal waveforms match over the many cycles received in the detector frequency bandwidth. Using a recently calculated formula, accurate to second post-Newtonian (2PN) order [order (v/c${)}^{4}$, where v is the orbital velocity], for the frequency sweep (dF/dt) induced by gravitational radiation damping, we study the statistical errors in the determination of such source parameters as the ``chirp mass'' scrM, reduced mass \ensuremath{\mu}, and spin parameters \ensuremath{\beta} and \ensuremath{\sigma} (related to spin-orbit and spin-spin effects, respectively). We find that previous results using template phasing accurate to 1.5PN order actually underestimated the errors in scrM, \ensuremath{\mu}, and \ensuremath{\beta}. Templates with 2PN phasing yield somewhat larger measurement errors because the 2PN corrections act to suppress slightly the importance of spin-orbit contributions to the phase, thereby increasing the measurement error on \ensuremath{\beta}. This, in turn, results in larger measurement errors on scrM and \ensuremath{\mu} because of the strong correlations among the parameters. For two inspiraling neutron stars, the measurement errors increase by less than 16%.
Mutational analysis of the embryo-specific urease locus of soybean.

By a non-destructive urease screen of M2 soybean (Glycine max [L.] Merr. cv. Williams) seeds, four truebreeding mutants (n4, n6, n7 and n8) were recovered which lack most (n6, n8) or all (n4, n7) embryo-specific urease activity. This trait was due to a single, recessive lesion at the Sun (seed urease-null) locus identified earlier in an exotic germplasm (PI 229324, Itachi). All sun mutants produced normal ubiquitous urease, the low abundance isozyme found in all soybean tissues examined. Tight mutants n4 and n7 accumulated no detectable embryo-specific urease protein or mRNA; n6 and n8 accumulated normal or near normal levels of urease mRNA but had seed urease protein levels approximately 5% and 0.5%, respectively, of the progenitor. Mutant n8 appeared to produce a low level of fully active urease (approximately 0.7% activity level, approximately 0.5% protein level) while n6 produced a higher level of an altered, nearly inactive urease (0.09% activity level, approximately 5% protein level). Urease alterations in n6 were manifested by its increased temperature sensitivity and variation in aggregation state and pH preference. Thus, mutations in the Sun locus affected both the level and the nature of the embryo-specific urease gene products indicating that Sun encodes the embryo-specific urease. We reported earliet that the Eul locus, which controls the aggregation state of the embryo-specific urease, is one map unit from Sun and that the Eul allele cis to sun is not expressed (Kloth et al. 1987). That the level of urease gene product, its aggregation state and other enzyme properties can be affected by induced sun mutations, suggests that the Eul and sun alleles are at the same locus.
Strength Analysis of Le Fort I Osteotomy Fixation: Titanium Versus Resorbable Plates

Purpose: The purpose of this study was to compare the biomechanical characteristics of metallic and polymeric fixation systems using a 3-dimensional skull model to simulate clinical conditions of maxillary advancement and loading. Material and Methods: Standard titanium, prebent titanium, and resorbable plates and mesh were applied to surgically altered polyurethane skulls. The constructs were loaded using an Instron machine (Instron Inc, Canton, MA) in anterior-posterior (AP) and inferior-superior (IS) directions. The load displacement, load to failure, and deformation magnitudes and modes of failure were recorded. Statistical studies included analysis of variance (ANOVA) at P <.05. Results: Elastic stiffness was different among groups in the AP direction, but no significant difference was found in the IS direction. The IS loading direction load displacement (stiffness) was significantly greater than that on AP loading. The maximum load for permanent deformation was larger in the AP direction, while the maximum load for breaking was larger in the IS direction. Conclusion: The overall evaluation of the model and test analyses supported the relative value of this in vitro system and study procedure. All systems showed load capacity magnitudes above 285 N (64 lbs) and more elastic resistance in the IS direction. The resorbable systems showed lower elastic stiffness compared with the titanium systems, but they appear to be adequate for fixation and withstanding the forces of mastication. © 2001 American Association of Oral and Maxillofacial Surgeons
Teaching and Learning the History Of Psychology Need Not Be Boring

(1982). Teaching and Learning the History Of Psychology Need Not Be Boring. Teaching of Psychology: Vol. 9, No. 3, pp. 183-184.
The effect of exercise on patellar tracking in lateral patellar compression syndrome

The influence of a physical therapy program on pain and patellar tracking was investigated clinically and radiologically with tangential views in 51 knees with lateral patellar compression syndrome. A pretest-posttest design was used to evaluate physical measurements of patellar alignment in subjects who had had patellofemoral pain for a minimum of 6 weeks. Eighty-four percent of the subjects were pain-free after an average of 8 weeks of rehabilitation or 11 physical therapy visits, with a mean quadriceps strength to total body weight ratio of 61% in women and 86% in men. The pretest-posttest difference in Merchant's congruence angle was significant at a probability of 0.0066 in the patients who were pain-free after exercise, demonstrating less lateral patellar tracking. The pretest-posttest difference in iliotibial band flexibility was significant at a probability of 0.0017, with the patients who were pain-free after exercise becoming more flexible. No significant differences were observed from before to after exercise in the patellofemoral index, Q angle, hamstring flexibility, thigh measurement, sclerotic subchondral bone, or sulcus angle. We were unable to predict which subjects would become pain-free with exercise by patellar position because the group that improved began more laterally tilted. The results of this study indicate that patellar tracking is improved with vastus medialis oblique strengthening, iliotibial band stretching, and joint mobility exercise in the majority of subjects with lateral patellar compression syndrome.
Removal of Zinc Ions from Aqueous Chloride Solutions by Solvent Extraction Using Alamine 308

Abstract A study has been undertaken to develop a solvent extraction system for zinc with Alamine 308 in aqueous chloride medium. The parameters investigated included reagent concentration, acid concentration, pH, aqueous to organic phase ratio, and rate of extraction and stripping. The study shows that zinc can be extracted rapidly and efficiently from aqueous chloride solutions. A number of aqueous stripping reagents removed more than 90% of the zinc from the organic phase with only one equilibration.
Experimental investigation of radiation from the interaction of an electron beam and a conducting grating.

Recent experimental results on the radiation generated from an electron beam passing closely over a conducting grating are presented. The most striking results are that the output power is 4 orders of magnitude more intense than that predicted by the Smith–Purcell explanation and that the output power increases exponentially with the beam thickness until it saturates at a thickness of a 1000 times the grating period. The recent theoretical model of Chang and McDaniel [Phys. Rev. Lett. 63, 1066 (1989); J. Opt. Soc. Am. B 7, 239 (1990)] is shown to compare favorably with these results.
Estimating qˆ in Quenched Lattice SU(2) Gauge Theory

Abstract The propagation of a virtual quark in a thermal medium is considered. The non-perturbative jet transport coefficient q ˆ is estimated in quark less SU(2) lattice gauge theory. The light like correlator which defines q ˆ , defined in the regime where the jet has small virtuality compared to its energy, is analytically related to a series of local operators in the deep Euclidean region, where the jetʼs virtuality is of the same order as its energy. It is demonstrated that in this region, for temperatures in the range of T = 400 – 600 MeV , and for jet energies above 20 GeV, the leading term in the series is dominant over the next-to-leading term and thus yields an estimate of the value of q ˆ . In these proceedings we discuss the details of the numerical calculation.
Acoustic Emission Test on Steel/Composite and Steel/Composite/Steel Built-Up Sections

Acoustic Emission (AE) has been widely used to monitor and inspect built-up steel/composite sections; primarily at the glue line. AE testing was conducted on steel-composite (SC) and steel-composite-steel (SCS) built-up sections to determine the glue line failure and damage sustained by the inner layer of the built-up section by putting the sensors on the inner and outer layers of the built-up sections. The straight specimens of steel/composite and steel/composite/steel were tested with load applied to only one steel layer. The AE sensors were placed on the outer steel component so that detected signals traveled through the loaded steel, glue lines, and the composite or the loaded steel component, two glue lines, composite and unloaded steel components of the built-up section(s). The AE signals received by the sensors placed on the loaded steel in tension was compared to signals of sensors placed directly opposite on the unloaded steel or composite to determine the effect the steel/composite and steel/composite/steel built-up sections had on the signal. AE signals were also compared to signals generated during tensile tests of steel specimens only and composite specimens only. AE parameters like amplitude, hits, counts, frequency, cumulative count, and rise time of the AE signals were recorded, analyzed, and compared. AE parameters were also compared to traditional material properties (like yield and failure stress and strain). Tested specimens were examined with a microscope and observations were compared and analyzed relative to AE and material parameters, and reported.Copyright © 2011 by ASME
Designing a probe beam and an ultraviolet holographic microinterferometer for plasma probing.

The requirements and techniques for time- and space-resolved picosecond probing of laser-produced plasmas are reviewed. The design and limitations of a holographic microinterferometer are discussed, and optical pulse techniques are presented. This technique can provide significant data for understanding the absorption of energy within laser-produced plasmas. The primary requirements are to measure the electron densities in the 1020–1021-e/cc range, with density contour velocities of 106 to 107 cm/sec and spatial resolution of 1 μm or better. For these velocities one requires a probe pulse duration of 3–30 psec, an UV wavelength as short as feasible, and large numerical aperture optics corrected for spherical aberration. Interferograms of laser-produced plasmas obtained at 2660 A with a combined resolution of 1 μm and 15 psec are presented.
Singular values and Schmidt pairs of composition operators on the Hardy space

Abstract We find the singular values and corresponding Schmidt pairs of a compact composition operator C φ induced by φ ( z ) = a z + b , where | a | + | b | 1 , on the classical Hardy space. We do so by solving a functional equation that is a generalization of Schroder's equation: find a function f, holomorphic on the open unit disc, and a complex number λ such that G ( z ) f ( ψ ( z ) ) = λ f ( ψ ( z ) ) , where ψ is a holomorphic self-map of the open unit disc with an interior fixed point and G is a bounded holomorphic function on the open unit disc. In addition, we find the spectrum of the weighted composition operator M G C ψ .