cssi/SciSciGPT-SciSciNet huggingface dataset:
Quality of life among pediatric patients with cancer: Contributions of time since diagnosis and parental chronic stress

Background Pediatric cancer is associated with a host of negative psychosocial consequences; however, outcomes vary extensively suggesting a need to better understand this variation. Empirical research suggests a positive association between time since diagnosis (TSD) and Quality of Life (QoL). In addition to TSD, family stressors have been found to be particularly important in predicting QoL among children. The current study examined parental chronic stress beyond TSD in explanation of QoL functioning among a sample of pediatric patients with cancer. Procedure Participants included 43 pediatric patients aged 5–18 years (Mage = 10.2 ± 3.6) who were undergoing oncological treatment. Parents reported on TSD, child's QoL, and their own chronic stress. Results TSD was associated with greater physical functioning (r = 0.30, P < 0.05). Parental chronic stress was associated with poorer emotional (r = −0.54, P < 0.01), physical (r = −0.41, P < 0.01), and social functioning (r = −0.44, P < 0.01). Further, hierarchal linear regression analyzes indicated parental chronic stress contributed incrementally beyond TSD in the explanation of physical (β = −0.37, t = −2.58, P < 0.01), emotional (β = −0.47, t = −3.51, P < 0.00), and social functioning (β = −0.38, t = −2.67, P < 0.01). Conclusions Parental chronic stress is associated with reduced levels of emotional, physical, and social functioning among pediatric patients. Future research is needed to further investigate the process by which chronic stress within the family interferes with adaptive coping among pediatric patients. In addition, clinical services may benefit from increased consideration of family factors, such as parental chronic stress, during oncological treatment. Pediatr Blood Cancer 2015;62:1232–1236. © 2015 Wiley Periodicals, Inc.
Comparison of Angiographic Burden of Coronary Artery Disease in Patients With Versus Without Hepatitis C Infection

Hepatitis C virus (HCV) infection is thought to be associated with an increased risk of coronary heart disease (CHD) events, perhaps secondary to increased inflammation. We sought to examine the angiographic burden of coronary artery disease (CAD) in patients with HCV compared to HCV-negative patients. All consecutive HCV RNA–positive patients (n = 61) who underwent coronary angiography at the University of Arkansas for Medical Sciences from 2001 to 2013 were identified. A parallel group of HCV-negative controls (n = 61), matched for age, gender, and indication for coronary angiography served as control. Angiographic burden of CAD was assessed by computing Gensini scores. Statistical analysis was performed using SPSS 21.0. Patients with HCV had significantly lower levels of total and low-density lipoprotein cholesterol. Preangiographic use of aspirin and statin was significantly lower in the HCV cohort. Number of patients with obstructive CAD was less in HCV group (23% vs 39%, p
The effect of honeycomb relative density on its effective in-plane elastic moduli : An experimental study

Honeycombs are discrete materials at the macro-scale level but their mechanical properties need to be calculated as a continuum material in order to simplify their design in engineering applications. The effective mechanical behavior of hexagonal honeycombs was studied by analytical means and correlated with experimental results for aluminum honeycombs. In particular, the effective in-plane elastic moduli of the honeycombs were studied as a function of their relative density. The effect of the bending, shear and axial deformations on various existing beam models was analyzed for both in-plane honeycomb directions. An experimental program was performed with honeycombs of densities ranging from the commercial low-density ones to the solid construction material. It is shown experimentally that the beam models describe well the material response in the direction of the honeycomb double wall. However, it is concluded that the effective elastic moduli for honeycombs with low relative densities are not similar in the two in-plane directions as predicted by previous studies.
Cross-layer system resilience at affordable power

In this paper, we address the challenge of achieving very high energy efficiency, while meeting target levels of performance and resilience to transient errors. We focus mainly at the processor chip level, while keeping in mind two ends of the system spectrum: (a) low power, real-time constrained embedded systems; and (b) extreme-scale high performance systems (or supercomputers). We advocate and illustrate the use of cross-layer resilience optimization as a general solution strategy.
Procollagen polypeptides containing cis-4-hydroxy-l-proline are overglycosylated and secreted as nonhelical pro-γ-chains

Abstract Incorporation of a proline analog into collagen polypeptides was studied by incubating matrix-free tendon cells from 17-day-old chick embryos with cis-4-hydroxy- l -proline. Velocity sedimentation of intracellular polypeptides provided further evidence that incorporation of the analog into protein prevented the pro-α- and pro-γ-chains of procollagen from folding into a stable triple-helical conformation. The size of the newly synthesized intracellular and extracellular protein was examined under conditions which prevented proteolysis during processing of the samples. In contrast to previous observations, the results demonstrated that there was little if any intracellular degradation of nonhelical pro-α-and pro-γ-chains containing the proline analog, and a fraction of the nonhelical pro-γ-chains was secreted into the medium without extensive degradation. In further studies, the cells were incubated with 14C lysine, and the synthesis of glycosylated hydroxylysyl residues was measured in control cells and in cells incubated with cis-4-hydroxy- l -proline. The results demonstrated that the content of glycosylated hydroxylysyl residues in nonhelical pro-γ-chains containing cis-4-hydroxy- l -proline was increased twofold as compared to the triple-helical procollagen in control cells. The results suggested that under control conditions folding into the triplehelical conformation limits the extent of glycosylation of collagen. If folding is prevented or delayed, procollagen polypeptides are more extensively glycosylated.
Aerothermodynamic Testing of the Crew Exploration Vehicle at Mach 6 and Mach 10

An experimental wind-tunnel program is being conducted in support of a NASA wide effort to develop a Space Shuttle replacement and to support the agency’s long-term objective of returning to the moon andMars. This paper documents experimentalmeasurementsmade on several scaled ceramic heat transfermodels of the proposedProject Orion Crew Exploration Vehicle. The experimental data highlighted in this paper will be used to assess numerical tools thatwill be used to generate theflight aerothermodynamic database. Global heat transfer images and centerline heat transfer distributions were obtained over a range of freestreamReynolds numbers and angles of attackwith the phosphor thermography technique. Temperature dataweremeasured on the forebody and afterbody andwere used to compute the heating on the vehicle as well as the boundary-layer state on the forebody surface. Several model support configurations were assessed to minimize potential aftbody support interference. Although naturally fully developed turbulent levels were not obtained on the forebody, the use of boundary-layer trips generated fully developed turbulent flow. Laminar and turbulent computational results are shown to be in good agreement with the data. In addition, the ability of the global phosphor thermography method to provide quantitative heating measurements in the low-temperature environment of the capsule base regionwas assessed and the lack of significant model support hardware influence on heating was shown.
Viral DNA sequences from incomplete particles of human adenovirus type 7

Abstract Large pools of empty viral capsids accumulate in cells infected by subgroup B human adenoviruses. Such infected cells also yield DNA-containing incomplete particles in larger quantities than cells infected with serotypes representing other adenovirus subgroups. DNA isolated from carefully purified classes of Ad7 incomplete particles was analyzed by restriction endonuclease cleavage, gel electrophoresis and electron microscopy. At least 90% of the DNA molecules in each sample consisted of sequences that extended from the left end of the viral genome map by variable lengths toward the right end. The average length of DNA is linearly related to the average buoyant density of the incomplete particles from which the DNA is isolated. The results indicate that each capsid contains one DNA molecule. There is also a specific association of the left end of the viral genome with assembled or assembling capsids. The characteristic distributions of Ad7 incomplete particles may result from intracellular pools of assembly intermediates in which the incompletely packaged DNA has been fragmented in vivo or by shear during preparative procedures.
Structure of polyethylene solid solutions: 2. Aspects of spectral deconvolution

Abstract Several methods of factor analysis have been evaluated and applied to deconvolute the infra-red spectra obtained for solid solutions of binary mixtures of PE 2000 and PE 1000. In addition to the crystalline orthorhombic form, these spectroscopic techniques also reveal packing disorder in the form of a monoclinic phase. This packing disorder can be correlated with the amount of conformational disorder associated with these samples.
Using an Integrated Library System to Create a Patient Education Database

The Patient and Family Education Committee of Hackensack University Medical Center and the Samuel and Sandra Hekemian Medical Library worked together to design and implement a database of patient education materials. The goal of the project was to use the customizations available in the Medical Library's new Integrated Library System to centralize and thereby increase access to patient education materials throughout the institution. This paper discusses the collaboration between the two groups, as well as the technical details of the project.
Recognition by a new chiral dimethyl‐substituted phenanthrolino‐18‐crown‐6 diester ligand of the enantiomers of various organic ammonium perchlorates

Two new chiral dimethyl-substituted phenandhrolino-18-crown-6 diester ligands [(S,S)-3] and [(S,S)-4] (see Figure 1) were prepared through the reactions of 1,10-phenanthroline-2,9-dicarboxylyl dichloride with (S,S)-dimethyl-substituted triethylene glycol and (S,S)-dimethyl-substituted benzotriethylene glycol, respectively. The complexation of (S,S)-3 with the enantiomers of various organic ammonium perchlorates in various solvent systems was studied by 1 H nmr spectral techniques and molecular mechanics. The degree of enantiomeric recognition was determined by the difference in the free energy of activation values (ΔΔG C ) and the difference in log K values for these interactions. The extensive π system in the ligand plays an important role for the strong interaction and recognition. The 1 HMR NOESY spectra and molecular mechanics calculations for the interactions of the new ligand with the organic ammonium salts further proved the existence of a π-π interaction
Structure of light neutron-rich nuclei through nucleon transfer and knockout reactions

Abstract Changes in shell closures through nucleon transfer and nucleon knockout reactions as spectroscopic probes are discussed. The intruder s-orbital in the ground and excited states of 12Be is studied through the 11Be(d,p) reaction. Signature of the 0 2 + long-lived state having an s-wave halo-like structure in 12Be is observed. One-neutron knockout from 24O shows a large spectroscopic factor for the s-orbital thereby establishing it as a new doubly magic nucleus at the drip-line.
At a cultural crossroads: Lessons on culture and policy from the New Zealand DISABILITY STRATEGY

Purpose. This article reports the findings and lessons from a year-long outcome evaluation of Objective 11 of the New Zealand Disability Strategy (NZDS): promote the participation of disabled Maori. It also looks at the larger implications for the creation of culturally appropriate and effective policy for indigenous peoples with disabilities.Method. Data were drawn from 34 semi-structured interviews conducted with ministry officials, service provider organisations, Maori consumers with disabilities and caregivers to Maori consumers.Results. Common themes included issues surrounding the effectiveness of the NZDS and the conflict between indigenous worldviews framed within a mainstream service paradigm. Themes unique to specific interview groups covered areas such as accountability structure design, perceived levels of cultural competency, collaboration across sectors and information exchange.Conclusion. Despite its shortcomings, the NZDS provides several pertinent lessons regarding the provision of cultur...
Non-dipolar interactions in dysprosium aluminum garnet

Abstract A number of experimental measurements on dysprosium aluminum garnet are combined to estimate the relative importance of non-dipolar contributions to the magnetic interactions. The main term is shown to be an enhancement (∼50%) of the Ising-like dipoke coupling between nearest neighbors.
Physicians contracting with managed care.

It has been observed that enrollees in managed care systems such as HMOs and PPOs have lower expenditures and utilization rates than those in conventional insurance plans. Few studies have investigated this issue by examining providers. This paper studies whether physicians with low costs are more likely to sign contracts with HMOs and PPOs in order to help explain the observation of lower expenditures and utilization rates by HMO and PPO enrollees. A logistic regression is applied to the data from the 198401985 Physician Practice Costs and Income Survey. The results do not show strong evidence that a physician's likelihood of contracting with HMOs and PPOs is related to the physician's practice costs and utilization decision of contracting with managed care systems are the physician's socio-demographics, the physician's practice region, and the market conditions.
Cardiac function in hyperthyroidism

It is accepted that thyroid hormones, thyrox-ine and tri-iodothyronine have direct inotropic and chronotropic effects on the heart. However, the mechanisms of manifestations are still uncertain. The following discusses and evaluates some of the theories regarding the interaction of these hormones with cardiac function.
Conductivity anisotropy and structural phase transition in Covellite CuS

Abstract Covellite CuS consists of alternating layers with compositions CuS and Cu2S2. We examine the anisotropy of the electrical conductivity and the origin of the structural phase transition in CuS by performing extended Huckel tight-binding band electronic structure calculations. Our study shows that CuS is a three-dimensional metal, but its conductivity should be much greater along the directions perpendicular than parallel to the c-axis. The partially empty valence bands of CuS have strong contributions from the sulfur 3p orbitals of the Cu2S2 layers, so that the oxidation state of CuS is better described by (Cu+)3(S2−)(S2− than by (Cu+)3(S−)(S22−). The structural phase transition of CuS is not driven by Fermi surface instability. A probable cause for this phase transition cannot be the bonding interactions between the Cu+ ions but the van der Waals interactions of the S…S contacts between the CuS and Cu2S2 layers.
Determinants of gating polarity of a connexin 32 hemichannel.

There is good evidence supporting the view that the transjunctional voltage sensor (Vj-sensor) of Cx32 and other Group 1 connexins is contained within a segment of the N-terminus that contributes to the formation of the channel pore. We have shown that the addition of negatively charged amino acid residues at several positions within the first 10 amino acid residues reverses the polarity of Vj-gating and proposed that channel closure is initiated by the inward movement of this region. Here, we report that positive charge substitutions of the 2nd, 5th, and 8th residues maintain the negative polarity of Vj-gating. These data are consistent with the original gating model. Surprisingly, some channels containing combinations of positive and/or negative charges at the 2nd and 5th positions display bipolar Vj-gating. The appearance of bipolar gating does not correlate with relative orientation of charges at this position. However, the voltage sensitivity of bipolar channels correlates with the sign of the charge at the 2nd residue, suggesting that charges at this position may have a larger role in determining gating polarity. Taken together with previous findings, the results suggest that the polarity Vj-gating is not determined by the sign of the charge lying closest to the cytoplasmic entry of the channel, nor is it likely to result from the reorientation of an electrical dipole contained in the N-terminus. We further explore the mechanism of polarity determination by utilizing the one-dimensional Poisson-Nernst-Plank model to determine the voltage profile of simple model channels containing regions of permanent charge within the channel pore. These considerations demonstrate how local variations in the electric field may influence the polarity and sensitivity of Vj-gating but are unlikely to account for the appearance of bipolar Vj-gating.
Effects of Mental Workload on Objective and Subjective Measures of Postural Stability

A substantial number of injuries and fatalities within occupational environments are due to falls, the majority of which are believed to be a result of loss of balance. This study investigated the effects of postural demands, visual cues, and mental activity on objective measures of postural sway and subjective assessment of postural stability. Measures of postural sway (mean distance, mean velocity, sway area) were obtained using a force plate, both during quiet standing and while performing mental arithmetic. In addition, a subjective postural stability scale was used to record perceptions of postural stability. Thirty participants completed all conditions with the effects of postural stance and visual cues being significant (ANOVA, α=0.05). Mental workload did not substantially alter postural sway or sensations of stability. High negative correlations between the objective and subjective measures were calculated (r = −0.81–0.95), with increases in subjective postural ratings corresponding to decreases ...
Hypodiploid, pseudodiploid, and normal karyotypes prevail in cytogenetic studies of medullary carcinomas of the thyroid and metastatic tissues

Medullary carcinoma of the thyroid (MCT), often a dominantly inherited neoplasm, derived from intrathyroid C-cells of neural crest origin, is one of the solid tumors least studied cytogenetically. The cells are difficult to grow in culture, only two cell lines having ever been established. Cytogenetic studies of only 5 tumors have been reported previously. In this paper we report on the cytogenetic analyses of 8 specimens of primary and/or metastatic MCT tumor tissue from 6 patients with familial disease, including more recent metastatic tumors in lymph node and femur of a patient whose thyroid and earlier lymph node metastases were described previously. Some of these specimens were harvested sequentially over time. Hypodiploid or diploid modal numbers prevailed with normal, pseudodiploid, or hypodiploid karyotypes.
The Academic Elite in Marketing: Linkages among Top-Ranked Graduate Programs

The 10 top-ranked graduate programs in marketing, based on a national survey of deans and top administrators, were linked to one another by these programs hiring one another's graduates. Approximately one-half of the faculty members in these 10 programs had graduated from one of these same 10 programs. It is suggested that this linkage helps these programs to maintain and enhance their prestige.
Seasonal variations in deposition and retention of cerium-141 and cesium-134 in cool desert vegetation

Deposition velocities and retention half-times were measured for 141Ce and 134Cs aerosols on big sagebrush (Artemisia tridentata) and squirreltail bottlebrush (Elymus elymoides). These aerosols were released over a native community in southeast Idaho during each of three seasons—spring, summer, and winter—to study the effects of plant development and growth on deposition velocity and retention. Air concentration during the release and vegetation concentration after the release were measured to determine deposition velocity. Friction velocity, roughness length, and particle size were measured. Vegetation concentration as a function of time was measured to determine retention half-time. There was no significant difference between nuclides for deposition velocity and retention half-time. Species differences were significant (P < 0.05). Squirreltail bottlebrush deposition velocities were 220, 700, and 820 μm s−1 in spring, summer and winter, respectively. Big sagebrush values were 1·6, 1·6, and 1·0 mms−1. Retention data indicated a rapid initial loss (half-times of 1–2d) followed by a slower loss (half-times of several weeks).
PREPARATION OF ANTISERA TO RECOMBINANT, SOLUBLE N-ACETYLGLUCOSAMINYLTRANSFERASE V AND ITS VISUALIZATION IN SITU

N-Acetylglucosaminyltransferase V (GlcNAc-T V) is a glycosyltransferase which transfers N-acetylglucosamine in beta(1,6) linkage to the alpha(1,6)-linked mannose residue of Asn-linked oligosaccharides. This enzyme is characterized by several unusual properties: GlcNAc-T V is the largest lumenal Golgi glycosyltransferase described thus far, and its multiple mRNA transcripts range from 4.5 to about 9.5 kb; GlcNAc-T V mRNA and activity are regulated by the src tyrosine kinase signalling pathway; in brain tissue, large levels of GlcNAc-T V mRNA are present, but only relatively low levels of catalytic activity can be detected; a lectin-resistant cell line, Lec4A, expresses active GlcNAc-T V which is mislocalized intracellularly. In addition, the cell surface oligosaccharide products of this enzyme have been hypothesized to regulate intercellular adhesion. In order to devise specific inhibitors of this enzyme it is necessary to understand its physical structure and how structural changes can influence its activity and localization. We have expressed milligram amounts of a soluble form of recombinant rat GlcNAc-T V, purified it from CHO cell-conditioned media, and used it to prepare specific antisera. This antisera binds selectively to GlcNAc-T V and has been used to visualize B-16 mouse melanoma cell GlcNAc-T V on immunoblots after SDS-PAGE. When the antisera was used in immunofluorescence microscopy experiments on permeabilized B-16 and baby hamster kidney cells, intense, specific staining was observed in intracellular structures which appear to correspond to the Golgi apparatus.
Ionic aggregate dissolution and conduction in a plasticized single-ion polymer conductor

Abstract Poly(ethylene glycol) plasticizer is blended with a PEO-based single-ion conductor to lower the glass transition temperature of the ionomer and solvate the lithium counterions. With increasing plasticizer content at room temperature, FTIR spectra indicate that the fraction of ions in isolated ion pairs increases relative to those in ionic aggregates, and X-ray scattering data indicate that the ionic aggregates are further apart than expected by dilution alone. Together these data show that the average size of ionic aggregates decreases as PEG plasticizer is added. The dissolution of aggregates into ion pairs promotes ion conduction. Coupled with faster segmental dynamics and ion mobility from the depressed Tg, the ionic conductivity of plasticized ionomers improved by two orders of magnitude at room temperature. Resolving the alpha relaxation of these ionomer blends reveals that the mechanism for ion transport is segmentally-assisted ion motion.
Interventional Radiologic Techniques for Screening, Diagnosis and Treatment of Patients with Renal Artery Stenosis

Renal artery stenosis resulting in renovascular hypertension or renal ischemia is a potentially treatable condition that results in increased morbidity and mortality, especially among older individuals. Sophisticated imaging techniques are used for screening and identification of affected patients to guide therapy. Treatment guidelines recommend intervention in patients with significant renal artery stenosis, although recent evidence has questioned the benefit of intervention in certain populations. Current research focuses on improving the specificity of imaging techniques and determining which imaging modalities best identify patients who will benefit from intervention.
Robust algorithms for restricted domains

We introduce a new definition of efficient algorithms for restricted domains. Under this definition, an algorithm is required to be “robust,” i.e., it must produce correct output regardless of whether the input actually belongs to the restricted domain or not. This is to be contrasted with the “promise” version of solving problems on restricted domains, in which there is a guarantee that the input is in the class, and an algorithm to “solve” the problem need not function correctly or even terminate if this guarantee is not met.The more stringent requirement of robustness in algorithms gives an important benefit: such algorithms are amenable to manipulation as building blocks of more general algorithms; in other words, composition of robust algorithms preserves robustness. In contrast, promise algorithms cannot be so composed.There exist problems which have a polynomial time promise solution, while being NP-hard if required to be robust. We show the perhaps surprising result that finding a maximum independent set in a well-covered graph (i.e., a graph in which every maximal independent set is of the same size) is NP-hard. An argument can be made that this hardness result is more meaningful than the trivial polynomial time promise algorithm.Graph classes provide interesting natural restricted domains; there are many problems which are efficiently solvable given a special and natural representation of a graph (i.e., a “model”), but which are open with respect to time complexity if the graph is given in a general form such as an adjacency list or an adjacency matrix. One such open problem is that of finding a maximum clique in unit disk graphs here, we give a polynomial time robust algorithm for this problem, i.e., given an input graph G in general form, the output is either a maximum clique for G or a certificate that G is not a unit disk graph. The existence of this algorithm is to be reconciled with the apparent contradiction posed by the facts: Recognizing whether an input graph given in general form is a unit disk graph is NP-hard; in fact, it is not even known to be in NP. Finding a maximum clique in an input graph given in general form is NP-hard.
Turnover of inositol phosphates in brain during ischemia-induced breakdown of polyphosphoinositides

Using either [(32)]ATP or [(3)H]inositol as precursors which were injected intraventricularly into rat brain, decapitative ischemic treatment resulted in a more rapid loss of labeled phosphatidylinositol 4,5-biphosphates than phosphatidylinositol 4-phosphates in the initial 30 s-1 min. When polyphosphoinositides were labeled with [(3)H]inositol, the breakdown of these compounds was accompanied by a time-dependent appearance of labeled inositol phosphates. Although the level of radioactivity of inositol trisphosphate was low, a peak labeling activity was shown at 30 s. The radioactivity of inositol bisphosphate showed an increase after a delay of 30 s, and reached a peak at 1 min before declining to the baseline level at 5 min. There was also a lag period of 30 s for the appearance of labeled inositol monophosphate, after which the radioactivity continued to increase in a biphasic manner for the entire 5 min period. Results indicate that decapitative ischemic treatment to rats can serve as an experimental model for assessing in vivo stimulation of the receptor-mediated signal transduction mechanism related to polyphosphoinositide breakdown and subsequent turnover of inositol phosphates in brain.
The organization of inventing and prototyping activities with children as design partners

One component of cooperative inquiry partners children and adults in the design of new technology. An ethnomethodological perspective will be used to analyze existing ethnographies of children as design partners. This analysis will generate questions about how inventing and prototyping activities are organized and accomplished. These questions can inform future ethnographies of children as design partners, and may also inform future partnered design activities.
Monte Carlo studies of selective adsorption on solid surfaces: Adsorption from vapour mixtures

We present the results of a Monte Carlo simulation study of adsorption from binary vapour mixtures on a solid surface using an isobaric method. The systems studied are models of simple mixtures adsorbed on a graphite surface. The interactions are modelled via Lennard-Jones 12–6 potentials, with the 10–4 potential used to describe interactions with the surface. The principal results of the calculations are the component molecular density distributions as functions of distance from the surface, from which information about selective adsorption can be obtained. These are studied for various states as the bulk composition changes at constant temperature and pressure. The states chosen are subcritical temperatures and pressures below the dewpoint pressure of the bulk mixture. The pure-component adsorption isotherms over a range of pressures from the Henry's law regime up to saturation are also determined. The mixture results are compared with the predictions of selective adsorption based upon (i) Henry's law, ...
Atrial Lead Malposition in a Dual Chamber (DDD,M) Pacemaker

A model 7000 pacemaker in the DVI mode emitted two stimuli, the first stimulating the right ventricle and the second 110 ms later. The atrial lead was found in the right ventricular outflow tract. The QRS complex produced by the atrial lead fell after the blanking period, and "committed" the ventricular stimulus 110 ms after the "atrial." Intracardiac electrography during the original implant would have enabled proper atrial lead position.
Community as resource: interaction between Lawrence Halprin and the students of Gaifield High School, Seattle

Abstract The Architectural Archives at the University of Pennsylvania houses a splendid collection of the work of landscape architect Lawrence Halprin. Alongside dozens of other projects, including such notable works as Sea Ranch and Ghiradelli Square, is a large set of documents that illustrate his design for Seattle Freeway Park. Included in the collection for this project are a great variety of renderings, conceptual sketches, site analyses, and project files and notes; one unique item stands out — a 1971 correspondence between Lawrence Halprin & Associates and students at the local Garfield High School. This document helps elucidate both the design process Halprin employed for Seattle Freeway Park and his philosophies regarding the nature of public architecture.
Specificity of Humoral Responses of Convalescent Channel Catfish to Edwardsiella ictaluri

Abstract Serum samples from 15 yearling channel catfish Ictalurus punctatus convalescing after experiencing enteric septicemia of catfish were distributed into three representative serum pools, each containing equal volumes of serum from five fish. Serologic recognition of each pooled serum sample against Edwardsiella ictaluri and Escherichia coli whole cells and against secretory antigen (exoantigen) derived from E. ictaluri was measured by enzyme-linked immunosorbent assays (ELISA). Serum samples were purified by affinity chromatography with a heterologous Ra,-mutant lipopolysaccharide that was derived from rough Salmonella typhimurium TV 119 and was covalently bound to an agarose matrix. Removal of antibodies recognizing the lipopolysaccharide by cross-reactive affinity purification caused significant decreases in serologic recognition of E. ictaluri (P < 0.10) and E. coli (P < 0.01) whole cells; however, serologic recognition of the E. ictaluri-specific exoantigen was not significantly decreased. Thes...
Studies on beef spleen cathepsin C1

Abstract A partially purified preparation of beef spleen cathepsin C has been examined in respect to the pH dependence of its hydrolytic action, the effect of several activators and inhibitors, and the kinetics of the hydrolysis of dipeptide amides and dipeptide esters which serve as substrates. By the use of l -prolyl- l -phenylalaninamide, the pH optimum of hydrolysis was found to be near 7. In addition to cysteine, β-mercaptoethanol and 2,3-dimercaptopropanol are good activators of the enzyme, whereas thioglycolic acid, glutathione, and cyanide are less effective. The kinetic constants for the hydrolysis of a series of structurally related substrates of cathepsin C have been estimated, and the results are discussed in relation to a hypothesis about the mode of enzyme-substrate interaction. Several l -phenylalanyl compounds have been found to be competitive inhibitors of the enzyme.
The Donner 280-Crystal High Resolution Positron Tomograph

We describe a stationary positron tomooraph desiqned for the rapid, accurate, three-dimensional imaging of positron-labeled compounds anywhere in the human body. The system consists of a large gantry containing lead shieldinq and a 92 cm diam ring of 280 closely-packed rectanqular NaI(Tl) crystals, lightpipes and phototubes; coincidence and address circuits; semiconductor histogram memory; a hard-wired reconstructor; and a gray-level CRT. Event rates, backgrounds and resolution test images are presented.
Postoperative Radiation Therapy for Non-Small Cell Lung Cancer

Adjuvant chemotherapy is now standard therapy following resection of large or locally advanced non-small cell lung cancer (NSCLC), with improvement in survival demonstrated in multiple randomized trials. Despite this, disease recurrence following optimal surgery and adjuvant systemic therapy is common. For patients with locally advanced disease, the majority will have a recurrence within the chest, most commonly at the bronchial stump or in hilar or mediastinal lymphatics. Postoperative radiation therapy (PORT) has been shown to decrease local and regional recurrences, an effect noted most clearly in stage N2 patients and those with positive surgical margins. An improvement in overall survival, similar to that following adjuvant chemotherapy, has not been consistently noted due to a high risk of treatment-related normal tissue toxicity in trials conducted over several decades. Improvements in radiation technique appear to have decreased the toxicity of PORT in more modern series, presumably increasing the potential benefit.
Commutative nil clean group rings

In [A. J. Diesl, Classes of strongly clean rings, Ph.D. Dissertation, University of California, Berkely (2006); Nil clean rings, J. Algebra383 (2013) 197–211], a nil clean ring was defined as a ring for which every element is the sum of a nilpotent and an idempotent. In this short paper, we characterize nil clean commutative group rings.
The Labor of Architecting

In Architecting , the TEAM inaugurates a unique form of theatrical labor. This labor moves beyond identitarian politics to imagine, in the midst of neoliberalism's tendencies to development through destruction, an entirely new kind of space in which an Idea, in Alain Badiou's sense, is resurrected.
Piezoelectric Actuation: State of the Art

Significant advances in smart material actuators have taken place in the past decade. The holy grail of actuator research is an architecture that can generate high displacement and force throughout a broad frequency range while not consuming a significant amount of electrical power. The large appeal of using smart material actuators stems from their high mechanical energy density. However, all smart material actuators generally have at least one shortcoming involving either mechanical stroke, force, or frequency capability. Whenever speed is a consideration, piezoelectric actuation is the most commonly employed. The purpose of this paper is to review the most current trends in piezoelectric actuation architectures. The paper does not present the theoretical details of each actuator, but instead strives to highlight the novel concepts used in each design to overcome the stroke limitation of the material.
A new blood protein which increases with vitamin K deficiency

Abstract By disc-gel electrophoresis the actual amount of active prothrombin protein has been found to decrease markedly in the blood of nutritionally vitamin K-deficient and of warfarin-treated rats. Concomitant with the decrease in plasma prothrombin, a significant increase has been found in another plasma protein, also adsorbable on BaSO4, but inert in the two-stage prothrombin assay. Vitamin K1 therapy of vitamin K-deficient rats decreased protein X and increased prothrombin. The new protein (protein X) runs slightly ahead of prothrombin on electrophoretic gels. The incorporation of labeled amino acids into purified protein X was found to be markedly increased in vitamin K deficiency, indicating an increased turnover of this protein. In contrast, the incorporation of amino acids into prothrombin was not affected by vitamin K deficiency, nor by vitamin K1. The inverse relationship of plasma protein X to prothrombin, dependent on vitamin K status of the animals, may indicate that protein X is somehow related to the mechanism of blood clotting.
Scattering coefficients and circuit analysis

The talk introduces the concept of scattering, impedance and cascade parameters for microwave networks. Particular attention is given to the characteristic impedance and how it relates to network measurements. Signal flow graphs is also considered. (13 pages)
The etiology and molecular genetics of human pigmentation disorders

Pigmentation, defined as the placement of pigment in skin, hair, and eyes for coloration, is distinctive because the location, amount, and type of pigmentation provides a visual manifestation of genetic heterogeneity in pathways regulating the pigment-producing cells, melanocytes. The scope of this genetic heterogeneity in humans ranges from normal to pathological pigmentation phenotypes. Clinically, normal human pigmentation encompasses a variety of skin and hair color as well as punctate pigmentation such as melanocytic nevi (moles) or ephelides (freckles), while abnormal human pigmentation exhibits markedly reduced or increased pigment levels, known as hypopigmentation and hyperpigmentation, respectively. Elucidation of the molecular genetics underlying pigmentation has revealed genes important for melanocyte development and function. Furthermore, many pigmentation disorders show additional defects in cells other than melanocytes, and identification of the genetic insults in these disorders has revealed pleiotropic genes, where a single gene is required for various functions in different cell types. Thus, unravelling the genetics of easily visualized pigmentation disorders has identified molecular similarities between melanocytes and less visible cell types/tissues, arising from a common developmental origin and/or shared genetic regulatory pathways. Herein we discuss notable human pigmentation disorders and their associated genetic alterations, focusing on the fact that the developmental genetics of pigmentation abnormalities are instructive for understanding normal pathways governing development and function of melanocytes.
Do corporate executives plan for social responsibility

The corporate planning process in large U.S. industrial firms must take a wide range of demands and pressures into account. Many different groups have an interest in the performance of the organization, and each exerts its own pressure, however subtle. Management responds to these pressures according to its own set of priorities.
Large Firms and Business Groups in Latin America: Towards a Theory Based, Contextually Relevant Research Agenda

ABSTRACT Large firms play an essential role in national competitiveness and economic development. With a goal of establishing a research agenda that is both well grounded in relevant theory and that addresses important challenges facing the region, in this paper we examine the organization and operation of large, privately owned firms in Latin America. As has been the case since at least the end of the 19th century, studies have found that Latin American firms are organized into business groups and continue to be owned and managed by families. We probe into the strengths and weaknesses of the Latin American version of business organization, including how groups are financed, their efforts to partner and/or compete with industrialized country multinationals (MNCs), and their chances of success in a global economy. Relying on recent advances in agency and institutional theory, we then develop a number of research propositions and suggestions for future research. RESUMEN. Grandes empresas juegan un papel ese...
Identifying non-inducible ventricular tachycardia origin utilizing defibrillator electrograms

Introduction Developing an ablation strategy when the clinical arrhythmia cannot be induced is a challenge.
Pathways for ischemic cytoprotection: Role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning

Caloric restriction (CR), resveratrol, and ischemic preconditioning (IPC) have been shown to promote protection against ischemic injury in the heart and brain, as well as in other tissues. The activity of sirtuins, which are enzymes that modulate diverse biologic processes, seems to be vital in the ability of these therapeutic modalities to prevent against cellular dysfunction and death. The protective mechanisms of the yeast Sir2 and the mammalian homolog sirtuin 1 have been extensively studied, but the involvement of other sirtuins in ischemic protection is not yet clear. We examine the roles of mammalian sirtuins in modulating protective pathways against oxidative stress, energy depletion, excitotoxicity, inflammation, DNA damage, and apoptosis. Although many of these sirtuins have not been directly implicated in ischemic protection, they may have unique roles in enhancing function and preventing against stress-mediated cellular damage and death. This review will include in-depth analyses of the roles of CR, resveratrol, and IPC in activating sirtuins and in mediating protection against ischemic damage in the heart and brain.
Intervertebral disk disease.

Neurologic dysfunction is the most common clinical manifestation of intervertebral disk disease. This article is a comprehensive review of intervertebral disk disease emphasizing clinical features, diagnosis and treatment of cervical and thoracolumbar disk disease. Clinical signs are determined by neuroanatomic localization and severity of spinal cord injury. Myelography is most commonly used for determining the location and extent of the disk protrusion/ extrusion; however, computed tomography and magnetic resonance imaging are also common adjunctive and primary diagnostic techniques. Summaries from recent studies will give the clinician an improved understanding on how to confront controversial issues regarding prophylactic and therapeutic management and prognosis.
Microwave resonance lamp absorption technique for measuring temperature and OH number density in combustion environments

A simple technique for simultaneous determination of temperature and OH number density is described, along with characteristic results obtained from measurements using a premixed, hydrogen air flat flame burner. The instrumentation is based upon absorption of resonant radiation from a flowing microwave discharge lamp, and is rugged, relatively inexpensive, and very simple to operate.
A novel analytical characterization for short-term plasticity parameters in spiking neural networks.

Short-term plasticity (STP) is a phenomenon that widely occurs in the neocortex with implications for learning and memory. Based on a widely used STP model, we develop an analytical characterization of the STP parameter space to determine the nature of each synapse (facilitating, depressing or both) in a spiking neural network based on presynaptic firing rate and the corresponding STP parameters. We demonstrate consistency with previous work by leveraging the power of our characterization to replicate the functional volumes that are integral for the previous network stabilization results. We then use our characterization to predict the precise transitional point from the facilitating regime to the depressing regime in a simulated synapse, suggesting 'in vitro' experiments to verify the underlying STP model. We conclude the work by integrating our characterization into a framework for finding suitable STP parameters for self-sustaining random, asynchronous activity in a prescribed recurrent spiking neural network. The systematic process resulting from our analytical characterization improves the success rate of finding the requisite parameters for such networks by three orders of magnitude over a random search.
The role of efferent connections of the suprachiasmatic nucleus in the control of circadian rhythms

The role of suprachiasmatic efferents in the control of circadian rhythms was investigated using female Long—Evans rats. Coronal knife cuts placed posterior to the suprachiasmatic nuclei of the hypothalamus failed to eliminate the feeding, drinking, and activity rhythms of the animals. On the other hand, this manipulation eliminated the estrous cycle of rats. These and previous results suggest that hypothalamic circuits involved in the generation of several behavioral rhythms are anatomically different from those regulating hormonal rhythms of the hypothalamo-hypophyseal system.
Differential Unfolding of α1 and α2 Chains in Type I Collagen and Collagenolysis

Abstract Collagenolysis plays a central role in many disease processes and a detailed understanding of the mechanism of collagen degradation is of immense interest. While a considerable body of information about collagenolysis exists, the details of the underlying molecular mechanism are unclear. Therefore, to further our understanding of the precise mechanism of collagen degradation, we used molecular dynamics simulations to explore the structure of human type I collagen in the vicinity of the collagenase cleavage site. Since post-translational proline hydroxylation is an important step in the synthesis of collagen chains, we used the DNA sequence for the α1 and α2 chains of human type I collagen, and the known amino acid sequences for bovine and chicken type I collagen, to infer which prolines are hydroxylated in the vicinity of the collagenase cleavage site. Simulations of type I collagen in this region suggest that partial unfolding of the α2 chain is energetically preferred relative to unfolding of α1 chains. Localized unfolding of the α2 chain leads to the formation of a structure that has disrupted hydrogen bonds N-terminal to the collagenase cleavage site. Our data suggest that this disruption in hydrogen bonding pattern leads to increased chain flexibility, thereby enabling the α2 chain to sample different partially unfolded states. Surprisingly, our data also imply that α2 chain unfolding is mediated by the non-hydroxylation of a proline residue that is N-terminal to the cleavage site in α1 chains. These results suggest that hydroxylation on one chain (α1) can affect the structure of another chain (α2), and point to a critical role for the non-hydroxylation of proline residues near the collagenase cleavage site.