cssi/SciSciGPT-SciSciNet huggingface dataset:
HIGH FREQUENCY MAGNETIC FIELD DISTRIBUTION IN REGION OF INITIAL SOLIDIFICATION WITHIN SOFT CONTACT ELECTROMAGNETIC CONTINUOUS CASTING MOLD OF BILLET

Experimental measurements and numerical analysis have been conducted to clarify the high frequency magnetic field distribution in the region of initial solidification within the soft contact EMCC (electromagnetic continuous casting) mold of billet. The effects of the divided types of EMCC mold, molten metal meniscus levels and coil turns on the distribution of magnetic field were investigated. The results show that the penetration of high frequency magnetic field in EMCC mold with open slit type is higher then that with closed slit type. By increasing the coil turns the effective range of magnetic field in the region of initial solidification increases. The molten metal meniscus level within the EMCC mold plays an important role on the surface quality of cast billets. When the meniscus level nears to the coil top the effective range of the magnetic filed becomes larger and the magnetic field distribution becomes uniform in the region of initial solidification of billet, which is helpful to improve the billet surface quality. On the base of the experiment and numerical study, the casting experiments for soft contact EMCC were carried out and the billets of Sn-10Pb alloy with high surface quality were obtained under high frequency magnetic filed with optimum operating parameters.
Serological Analysis of Toxoplasmosis in Guangzhou City in 2004

Objective To investigate the anti-toxoplasma IgG level in livestock workers, people who contacted animals and pregnant women in Guangzhou and to offer the basic control strategy for the disease. Method ELISA was used to detect IgG of anti-Toxoplasma gondii in the people of different occupation and locations (districts or counties) in Guangzhou.Results 2,526 serum samples were analyzed. 206 people were seropositive, with a positive rate of 8.16%. The positive rates in counties (9.48%) and suburbs (7.91%) were higher than that in city (4.73%) respectively. The positive rates in the farmer (10.26%) and livestock workers (10.84%) were the highest amount all the occupations. It followed with the people who contacts with cat or canine (9.97%), and meatpacking workers or sellers (8.98%). The positive rates in male and female were 8.03 % and 8.31% respectively. The positive rates increased with age in the age group of 40 to 60. Conclusion Toxoplasmosis is zoonosis. The effective integrated control measure is to change people's bad habit and arouse their safety consciousness.
Multisensory Integration Reveals Temporal Coding across a Human Sensorimotor Network.

Investigations of how the nervous system represents, transmits, and transforms sensory information provide invaluable insights for the field of neuroscience as a whole. Early sensory neuroscience typically focused on neural responses to sensory inputs of a single modality. These approaches are
Vertical rectus transpositions in sixth nerve palsies.

Purpose of review There are many surgical options to address a sixth nerve palsy including transpositions of the vertical recti to the lateral rectus. This review will summarize the results from variations on transpositions as they apply to sixth nerve palsies. Recent findings Transposition of both vertical recti with posterior fixation creates the greatest correction of esotropia in primary position with largest field of single vision. Transposition of the superior rectus alone preserving anterior segment circulation achieves effects similar to transposition without posterior fixation. Augmentation with partial transposition also creates similar improvement in esotropia with possibilities for adjustable sutures and circulation preservation. Summary These various options on transpositions allow options to specifically address surgeon preferences and patient needs to select the appropriate surgery.
Knowing Habitual Domains

As discussed in Chapter 5, each one of us has a unique habitual domain (HD). Like snails carrying their shell wherever they go, we carry our HD wherever we go. As the HD is invisible, unwritten, unspoken, but always present, it affects our decisions and behavior continuously yet unconsciously.
Abstract 4805: In vitro characterization of novel inhibitors of ROCK and MRCK kinases as anticancer agents

Metastatic cancers are the second leading cause of deaths in the USA. RhoA and Cdc42 play critical roles in the regulation of plasticity of cancer cell migration/invasion and cell proliferation. ROCK1/2 and MRCKa/â are downstream kinases in the signaling pathways associated with cancer cell migration and invasion. Hence, we hypothesized that simultaneous targeting of these two kinase families would be an effective therapeutic strategy to block migration, invasion, and growth of metastatic cancers. We have identified DJ4 as a novel inhibitor of ROCK and MRCK kinases. In the cellular functional assays, DJ4 treatment significantly blocked stress fiber formation, and inhibited migration and invasion of multiple cancer cell lines in a concentration dependent manner. To study the critical functional groups required for its activity, we have modified the chemical structure of DJ4 at various functional groups and synthesized several analogs of DJ4 to perform the structural activity relationship (SAR) study for their ROCK1 inhibition. The effectiveness of these compounds were further investigated using National Cancer Institute9s drug screening program in 60 human cancer cell lines representing nine different cancer types. These compounds effectively inhibit migration and invasion of multiple cancer cell types. Selected analogs were tested for their anti migration, pro-apoptotic, and anti-proliferative effects in breast cancer cells. Our studies strongly indicate that DJ4 and its analog, DJ110, are potent inhibitors of ROCK1, ROCK2, MERKa and MRCKâ. The results of our finding will be discussed. Citation Format: Dhimant H. Desai, Vijay P. Kale, Jeremy A. Hengst, Taryn E. Dick, Ashley L. Colledge, Shantu G. Amin, Jong K. Yun. In vitro characterization of novel inhibitors of ROCK and MRCK kinases as anticancer agents. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4805.
Hind Swaraj and Rural Utopia

Time magazine’s cover for June 2006 (Asian and US editions) carried the declamatory headline ‘India Inc.’, an emphatic confirmation of the widely held belief in the increasing economic and political clout of ‘the world’s biggest and rowdiest democracy’ (Robinson, ‘A Young Giant’). Central to this picture of a ‘marching’ India are the industry and service sectors and a burgeoning consumer base whose global connections are widely seen as bridging what chasms existed between India and the West. This popular image of India’s prosperity has its focal point very firmly in the all-powerful city, teeming metropolises like New Delhi, Kolkata, Mumbai, and Bangalore where sweeping changes in the geography, demography, and cultural history have created a compelling symbol of the city as the hub of progress. In such a light, Mohandas Gandhi’s vision of village economics and rural living, so salient to the trajectory of the Indian political movement for independence from British rule in the first three decades of the twentieth century, appears to have lived out its short life. The boom in electronic technology, the proliferation of megacities, the creation of urban outsourcing, and the complex trends of labour migration away from villages, all seem to hint at the death of the village as the symbol of India, a symbol that long bore the burden of many (often, either negative or, at best, romantic or pastoralized) representations of colonial and pre-colonial India.
Angola 1993–1999

As explained in Chapter 2, much of the blame for the collapse of the first Angolan peace process in late 1992 was leveled at the UN. The greatest criticisms were that it tried to implement an inappropriate mandate in too short a time period with too few personnel and insufficient finances. Finally, it was also criticized for agreeing to winner-takes-all democratic elections in a culture ill suited to its inevitable consequences.
InterPlanetary Wayback: Peer-To-Peer Permanence of Web Archives

We have integrated Web ARChive (WARC) files with the peer-to-peer content addressable InterPlanetary File System (IPFS) to allow the payload content of web archives to be easily propagated. We also provide an archival replay system extended from pywb to fetch the WARC content from IPFS and re-assemble the originally archived HTTP responses for replay. From a 1.0 GB sample Archive-It collection of WARCs containing 21,994 mementos, we show that extracting and indexing the HTTP response content of WARCs containing IPFS lookup hashes takes 66.6 min inclusive of dissemination into IPFS.
Wide bandwidth (30 GHz) slab-coupled optical waveguide photodiodes

We describe design enhancements to increase the bandwidth of variable-confinement slab-coupled optical waveguide photodiodes to 30 GHz while maintaining good external responsivity (0.5 A/W), high 1-dB compression current (> 25 mA), and high linearity (OIP3 > 30 dBm).
Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D2 Receptor (D2R) Biased Agonism

The development of bivalent ligands has attracted interest as a way to potentially improve the selectivity and/or affinity for a specific receptor subtype. The ability to bind two distinct receptor binding sites simultaneously can allow the selective activation of specific G-protein dependent or β-arrestin-mediated cascade pathways. Herein, we developed an extended SAR study using sumanirole (1) as the primary pharmacophore. We found that substitutions in the N-1- and/or N-5-positions, physiochemical properties of those substituents, and secondary aromatic pharmacophores can enhance agonist efficacy for the cAMP inhibition mediated by Gi/o-proteins, while reducing or suppressing potency and efficacy toward β-arrestin recruitment. Compound 19 was identified as a new lead for its selective D2 G-protein biased agonism with an EC50 in the subnanomolar range. Structure–activity correlations were observed between substitutions in positions N-1 and/or N-5 of 1 and the capacity of the new bivalent compounds to se...
miR-202 Diminishes TGFβ Receptors and Attenuates TGFβ1-Induced EMT in Pancreatic Cancer

Previous studies in our laboratory identified that 3-deazaneplanocin A (DZNep), a carbocyclic adenosine analog and histone methyl transferase inhibitor, suppresses TGFβ-induced epithelial-to-mesenchymal (EMT) characteristics. In addition, DZNep epigenetically reprograms miRNAs to regulate endogenous TGFβ1 levels via miR-663/4787-mediated RNA interference (Mol Cancer Res. 2016 Sep 13. pii: molcanres.0083.2016) (1). Although DZNep also attenuates exogenous TGFβ-induced EMT response, the mechanism of this inhibition was unclear. Here, DZNep induced miR-202-5p to target both TGFβ receptors, TGFBR1 and TGFBR2, for RNA interference and thereby contributes to the suppression of exogenous TGFβ-induced EMT in pancreatic cancer cells. Lentiviral overexpression of miR-202 significantly reduced the protein levels of both TGFβ receptors and suppressed TGFβ signaling and EMT phenotypic characteristics of cultured parenchymal pancreatic cancer cells. Consistently, transfection of anti-miRNAs against miR-202-5p resulted in increased TGFBR1 and TGFBR2 protein expressions and induced EMT characteristics in these cells. In stellate pancreatic cells, miR-202 overexpression slowed growth as well as reduced stromal extracellular membrane matrix protein expression. In orthotopic pancreatic cancer mouse models, both immunodeficient and immunocompetent, miR-202 reduced tumor burden and metastasis. Together, these findings demonstrate an alternative mechanism of DZNep in suppressing TGFβ signaling at the receptor level and uncover the EMT-suppressing role of miR-202 in pancreatic cancer.Implications: These findings support the possibility of combining small molecule-based (e.g., DZNep analogs) or large molecule-based (e.g., miRNAs) epigenetic modifiers with conventional nucleoside analogs (e.g., gemcitabine, capecitabine) to improve the antimetastatic potential of current pancreatic cancer therapy. Mol Cancer Res; 15(8); 1029-39. ©2017 AACR.
Prospective, Randomized Study of Radiation Dose Escalation With Combined Proton-Photon Therapy for Benign Meningiomas.

Purpose To assess the outcomes of benign meningiomas (BM) treated to two radiation dose levels. Methods and Materials We randomly assigned patients (1:1) with incompletely resected or recurrent BM to 2 radiation doses: 55.8 Gy(relative biological effectiveness [RBE]) and 63.0 Gy(RBE) of fractionated combined proton–photon radiation therapy. The primary endpoint was local control with hypothesis of improved tumor control with higher dose. Secondary endpoints included progression-free survival, overall survival, and rates of treatment-related toxicities. Results Between 1991 and 2000, 47 patients were randomized. Three patients were excluded for nonbenign histology; therefore, 44 patients were analyzed: 22 who received 55.8 Gy(RBE) and 22 who received 63.0 Gy(RBE). The median follow-up was 17.1 years. Local control for the entire cohort was 98% at 10 years and 90% at 15 years. Of the 5 patients with local recurrence, 4 occurred after 10 years of follow-up, and 3 were in the lower dose group (P=.322). In the modified intention to treat analysis, there was no difference in progression-free survival (P=.234) and overall survival (P=.271) between arms. A total of 26 patients (59%) experienced a grade 2 or higher late toxicity, including 9 patients (20%) incurring a cerebrovascular accident (CVA), 7 of which were deemed at least possibly attributable to irradiation. The median time between completion of radiation therapy and CVA was 5.6 years (range, 1.4-14.0 years). Conclusions Fractionated combined proton–photon radiation therapy is effective for BM, with no apparent benefit in dose escalation. Further investigation is needed to better define the risk of late toxicities, including CVA after cranial radiation therapy.
Secret Histories of the Virginia–North Carolina State Line: A Template for Literary Interventions into Property

This article tests the value of using William Byrd’s Secret History of the Line (c. 1730s), which chronicles the running of the Virginia–North Carolina boundary, as a guide to the state line today. Byrd’s Secret History belongs to a special genre of literature instrumental to land survey projects and property making. Byrd wrote both to entertain and to promote settlement. That Byrd’s account is so well-written—witty, bawdy, and vividly descriptive—contributes to its lasting influence over the region. Thus Byrd offers a valuable field guide not only to the history but to the entanglement of culture and nature that continues to make this place. Furthermore, Byrd’s text inspired Susan Howe’s long poem “Secret History of the Dividing Line” ([1978] 1996), which critiques the legacy of Byrd’s colonialist landscapes. Both Byrd and Howe expand our understanding of property as a literary genre, shaped by storytelling and graphic representation, and so open up more imaginative and concrete ground for our own interv...
Stimulus-Driven and Goal-Directed Attentional Control

Vision is used by organisms to obtain information about the local spatial layout. Selection is of its essence: relevant objects and locations are selected for further processing and irrelevant ones are ignored. The control of attention is usually assumed to be of two types: top-down or goal-directed control on the one hand, and bottom-up or stimulus-driven control on the other. In most cases, some combination of these two influences determines how attention is deployed. Here I review the recent behavioral literature concerned with stimulus-driven and goal-directed visual attention.
Partially Invariant Patterns for LFSR-Based Generation of Close-to-Functional Broadside Tests

Close-to-functional scan-based tests are expected to create close-to-functional operation conditions in order to avoid overtesting of delay faults. Existing metrics for the proximity to functional operation conditions are based on the scan-in state. For example, they consider the distance between the scan-in state and a reachable state (a state that the circuit can visit during functional operation). However, the deviation from functional operation conditions can increase during a test beyond the deviation that is measured by the scan-in state. To ensure that the deviation does not increase, this article introduces the concept of a partially invariant pattern. The article describes a procedure for extracting partially invariant patterns from functional broadside tests whose scan-in states are reachable states. Being partially specified, partially invariant patterns are suitable for test data compression. The article studies the use of partially invariant patterns for linear-feedback shift-register (LFSR) based test data compression. Noting that a seed may not exist for a given partially invariant pattern with a given LFSR, the procedure described in this article uses an iterative process that not only matches a seed to a partially invariant pattern, but also adjusts the partially invariant pattern based on the test that the seed produces. The article also addresses the selection of LFSRs for the generation of close-to-functional broadside tests based on partially invariant patterns. Experimental results are presented to demonstrate the feasibility of the procedure.
King, Conscience, and the Monstrous Other in Calderón’s Amor, honor y poder

Dans sa premiere comedie Amor, honor y poder (Amour, Honneur et Pouvoir) qui est la reincarnation litteraire de la legende de la Comtesse de Salisbury, Calderon depeint la resistance a la tyrannie par une sujette du roi, pour laquelle les sacrements et la conscience prevalent sur l’obeissance d’un vassal a son suzerain. Quoique d’abord le roi, Edouard, n’ait pas reussi a seduire la fille du comte de Salveric (Salisbury), a la fin il contraint sa sujette vertueuse a l’epouser. Ce denouement apparemment heureux de la piece provoque un effet troublant qui sape l’ideologie officielle de l’absolutisme royal en Espagne de la premiere moitie du XVIIe siecle.
Gaps and Future Directions in Lung Transplantation

Lung transplantation (LTX) may be the only intervention that can improve quality of life for individuals with advanced lung disease and can prolong survival in advanced lung diseases such as idiopathic pulmonary fibrosis or cystic fibrosis that progress despite non-transplant therapies. However, some patients considered for lung transplantation are extremely ill and require ventilator and/or circulatory support as a bridge to transplant. Indeed, many early complications can threaten lung allograft viability, and delayed onset of decline in function due to chronic lung allograft dysfunction (CLAD) or other posttransplant complications such as opportunistic infection significantly impact recipient survival and long-term outcomes. Many advances in pre- and posttransplant management have led to improved outcomes over the past decade. These include the creation of sound guidelines for candidate selection, improved surgical techniques, improved methods for donor lung preservation, advances in the suppression and treatment of allograft rejection, the development of prophylaxis protocols to decrease the risk of opportunistic infection, more effective therapies for treating infectious complications, and the development of a clinical practice guideline to treat and manage CLAD. Nonetheless, many gaps in knowledge concerning the optimization of the initial transplant procedure, perioperative management, and the prevention of subacute and chronic allograft dysfunction persist. This chapter discusses evolving advances in the field of lung transplantation, identifies persistent gaps in knowledge, and discusses what the future may hold for lung transplantation as a more attractive and viable option for patients confronted with premature death due to end-stage lung disease.
Evidence-Based Bundled Quality Improvement Intervention for Reducing Surgical Site Infection in Lower Extremity Vascular Bypass Procedures.

Background Surgical site infection (SSI) poses a significant burden to patients and healthcare resources. Vascular Quality Initiative (VQI) data identify a higher rate of SSIs for lower extremity bypass than other vascular procedures. Bundled interventions have successfully reduced SSIs in other surgical procedures. Study Design We evaluated our institution-specific VQI data for modifiable risk factors associated with index hospitalization SSI from January 2012 through October 2015. We implemented an evidence-based lower extremity bypass operation SSI reduction bundle (ie perioperative chlorhexidine showers and transverse groin incisions) and prospectively enrolled all patients who had lower extremity bypass procedures, with a target adherence rate of 50% per bundle component. Bundle adherence and SSI events were measured from March 2016 through August 2017. We carried out a pre-post evaluation of bundle effectiveness in reducing index hospitalization SSI. Results In the pre-intervention period, 43 of 234 (18%) patients had SSI events. The only risk factors associated with SSI (ie female sex, diabetes, overweight BMI) were not readily modifiable. In an 18-month period after introduction of our intervention, adherence rates to preoperative chlorhexidine showers, a transverse incision, and a postoperative chlorhexidine shower were 71% (52 of 73), 48% (24 of 50), and 88% (64 of 73), respectively. Compliance with all applicable bundle components was 36% (26 of 73). The SSI rate post-intervention decreased from 18% to 4% (3 of 73). Intention-to-treat multivariable analysis showed a 97% SSI risk reduction with the bundle (p = 0.002). As-treated analysis identified 85% (p = 0.02) and 62% (p = 0.047) SSI risk reductions from the preoperative and postoperative chlorhexidine showers, respectively. Conclusions In this evaluation study of the effectiveness of a quality improvement intervention, SSIs were markedly decreased after implementation of our evidence-based bundle for lower extremity vascular bypass procedures.
Continuous Flow from Inferior Vena Cava into the Right Atrium Predicts Normal Central Venous pressure

: Background: Respiratory variation in Inferior Vena Cava (IVC) diameter is validated for estimation of Right Atrial Pressure (RAP) by echocardiogram. Although IVC flow into the Right Atrium (RA) can be appreciated in parasternal views, it is not routinely evaluated. We have observed an uninterrupted continuous wave (CW) Doppler flow signal from the IVC during sampling of the Tricuspid Regurgitation (TR) jet. Objectives: The present study aimed to show that this uninterrupted signal was a surrogate for normal/low RAP. Methods: This retrospective study was conducted on 500 consecutive echocardiograms and sought continuous flow from IVC into the RA in the subcostal view. RAP was then measured using IVC dynamics like size and respirophasic variation. Analysis was performed by comparison of the percentages. Results: Out of the 500 echocardiograms, 60 (12%) had Doppler evidence of continuous IVC flow into the RA. Among these 60 echocardiograms, RAP was calculated in 57 patients. Accordingly, RAP was 3 mmHg in 54 (95%) and 8 mmHg in 3 (5%) patients. RAP could not be estimated in three patients due to lack of visualization of IVC. Furthermore, RA volume index was normal in 51 patients (85%), but increased in 9 ones (15%). Right Ventricular (RV) function was also normal in 48 (96%) and low in 2 (4%) patients. Conclusion: The study findings supported the hypothesis that continuous flow from IVC into RA on CW Doppler is a surrogate for IVC dynamics in normal/low RAP and is particularly useful when subcostal views are suboptimal or inaccessible due to poor acoustic windows.
Content analysis of cyber insurance policies: how do carriers price cyber risk?

Thousands of data breaches occur each year with some costing millions of dollars. Consequently, cyber insurance has grown rapidly in the past decade. In this research, we conduct the first rigorous qualitative study of actual insurance policies.
Origami Inspired Solar Panel Design.

The goal of this paper was to take a flat solar panel and make cuts on the panel to make smaller, but still viable solar panels. These smaller solar panels could then be arranged in a tree-like design. The hope was that by having solar panels faced in different directions in 3-dimensional space, the tree system would be able to pick up more sunlight than a flat solar panel. The results were promising, but this project did not take every factor into account. Specifically, optimum shape, temperature and the resistance of system, reflection of sun-rays were not explored in this project. This paper will take an approach from origami paper folding to create the optimum arrangement that will allow the overall system to absorb the maximum energy. Since the system stays stationary throughout the day, it can reduce the maintenance cost and excess energy use because it does not require solar tracking. In this project we have implemented a variety of Evolutionary Algorithms to find the most efficient way to cut a flat solar panel and arrange the resulting smaller panels. Each solution in the population will be tested by computing the amount of solar energy that is absorbed at particular times of the day. The EA will be exploring different combinations of angles and heights of the smaller panels on the tree such that the system can produce the maximum amount of power throughout the day. The performance of our Evolutionary algorithms are comparable to the performance of flat solar panels. Keywords: - Evolutionary Programming, Evolution Strategy, Genetic Algorithm, Solar Panel Optimization.
Engaging with Indigenous Research

Community-based participatory research (CBPR) within Indigenous communities aims to share project responsibilities and benefits equitably among community members and researchers. CBPR relies on authentic relationships that take time to build; so how does a student from a colonial institution such as Queen’s University build the necessary relationships? As a Kanien'keha:ka (Mohawk) student about to begin my graduate degree focusing on health promotion through a CBPR partnership with Indigenous communities, I will share my story and background of disconnect, as well as the identity-struggles I had prior to deciding that this field of research was right for me. Through this presentation, I will discuss the upfront process of being involved with Indigenous research as an Indigenous student, an advocate, and an ally. Regardless of Indigenous status, examining the research process in the context of individual positionality and researcher self-awareness is critical to successful CBPR research. My goal is to provide both Indigenous and non-Indigenous research trainees with important insight about positionality, identity, power, and relationship-building as vital components of community-engaged research. I will discuss how the principles of CBPR align with Indigenous ideals and how these can be leveraged to establish connections that can support meaningful research with Indigenous communities.
Use of Completion Lymph Node Dissection for Sentinel Lymph Node-Positive Melanoma.

Background For patients with sentinel node-positive melanoma (SNPM), randomized trials, first reported in 2015, found no benefit for routine completion lymph node dissection (CLND) in selected patients. This study examines time trends in CLND and explores institutional and clinical factors associated with CLND. Study Design The National Cancer Database was queried for patients older than 18 years from 2012 to 2016 with SNPM. A high-volume center was defined as >80th percentile for number of sentinel node procedures. Poisson regression assessed temporal trends and identified patient, pathologic, and institutional characteristics associated with CLND. Results From 2012 to 2016, we identified 7,146 patients with SNPM. The proportion of patients undergoing CLND was steady in 2012 to 2014 (61% to 63%), but decreased to 57% in 2015 and 50% in 2016 (p Conclusions Completion lymph node dissection in SNPM decreased over time, with the greatest change in 2016. Several patient, pathologic, and institutional characteristics were associated with likelihood of CLND. As evidence supports close observation for selected patients, efforts should be undertaken to improve and standardize patient selection for CLND across institutions caring for patients with melanoma.
The Characteristics of the Phase-Energy Image Spectrum

Here, we propose a novel method to determine oscillation. The method is based on the analysis of one- and two-dimensional power spectra of the images or video sequences. Also, we describe the amplitude changing at zero phases. In addition, we find the correlation between the type of object oscillation and graphical representation of the power spectrum and analyse how it influenced by the motion blur. Finally, we design a novel tool in a view of the vector field of the power spectrum for image and video sequences analysis.
A data-driven surrogate to image-based flow simulations in porous media

Abstract The objective for this work is to develop a data-driven surrogate to high-fidelity numerical flow simulations using digital images of porous media. The proposed model can capture the pixel-scale velocity vectors in a large verity of digital porous media created by random two-dimensional (2D) circle packs. To develop the model, images of the 2D media (binary images of solid grains and void spaces) along with their corresponding velocity vectors at the pixel level computed using lattice Boltzmann simulation runs are used to train and to predict the solutions with a high accuracy in much less computational time. The velocity vector predictions made by the surrogate models are used to compute the permeability tensor for samples that have not been used in the training. The results show high accuracy in the prediction of both velocity vectors and permeability tensors. The proposed methodology harness the enormous amount of generated data from high-fidelity flow simulations to decode the often under-utilized patterns in simulations and to accurately predict solutions to new cases. The developed model can truly capture the physics of the problem and enhance the prediction capabilities of the simulations at a much lower cost. These predictive models, in essence, do not spatially reduce the order of the problem. They, however, possess the same numerical resolutions as their Lattice Boltzmann simulations equivalents do with the great advantage that their solutions can be achieved by a significant reduction in computational costs (speed and memory).
A digital media attention diversion improves mood and fear in patients receiving chemotherapy for recurrent gynecologic malignancies: results of a randomized trial

Background Recurrent gynecologic cancer patients experience symptoms that affect psychologic, emotional, social, and physical well-being. Chemotherapy can further exacerbate these symptoms. Poor mood, pain, and fatigue are linked and are detrimental to quality of life. Interventions targeting these symptoms may improve patient-reported outcomes and performance status. Objectives To determine the ability of a humorous digital media attention diversion to improve symptom domains of positive and negative mood during chemotherapy for patients with recurrent gynecologic cancers. Study design This randomized, crossover clinical trial enrolled women with recurrent gynecologic cancers. Subjects participated over three cycles of chemotherapy. The primary outcome was the change in mood on the validated Positive and Negative Affect Scale-Extended (PANAS-X) instrument, which measures positive and negative affect domains. All subjects completed the PANAS-X after receiving chemotherapy during cycle 1 on study. In atudy arm 1, subjects watched their choice of humorous movies on a digital media device while receiving chemotherapy during cycle 2 on study. They selected from non-humorous movies during cycle 3 on study. In arm 2, the order of movies was reversed. After each cycle, mood, fatigue, and other patient-reported outcomes were assessed for comparison with baseline measurements. Results The target enrollment of 66 subjects was achieved. Subjects watched humorous content for an average of 96.0 min and non-humorous content for an average of 62.5 min. Negative mood improved after exposure to humorous (p=0.017) and non-humorous content (p=0.001). Patient-reported fear also improved after exposure to both humorous (p=0.038) and non-humorous content (p=0.002). Subjects reported higher use of affiliating and self-effacing humor types. Conclusions Offering patients a choice of digital media during chemotherapy significantly improved negative mood and fear. This was seen with both humorous and non-humorous content. This low-cost and low-risk intervention should be implemented as an attention diversion to improve negative mood and fear for patients receiving chemotherapy.
The COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) trial: can we deliver on its promise?

The primary goals of treatment for patients with stable (chronic) coronary artery disease (CAD) include the prevention of death and myocardial infarction (MI) and the relief of ischemic symptoms. In this regard, medical therapy and revascularization comprise complementary approaches. Despite the
Geothermal Technology for Sustainable Climate Control in an Historic House

This paper discusses integration of twenty-first-century direct-exchange geothermal technology with nineteenth-century heat supply infrastructure to provide climate control at The Breakers, Newport...
Michael Milken's Spreadsheets: Computation and Charisma in Finance in the Go-Go ’80s

Wall Street lore holds that “junk bond” king Michael Milken once blamed the tumultuous changes that roiled American finance in the 1980s on VisiCalc, the pioneering spreadsheet software. This article takes Milken's quip as a prompt to explore the practical and cultural place of computing in 1980s finance. It reveals that PCs, especially spreadsheets, augmented the capacities of 1980s financiers in three ways—surveillance, valuation, and imagination—each crucial to Milken's “machine.” Yet this article also exposes another side to Milken's success, grounded not in computation but charisma. Milken's power lay both in innovative command over novel technicalities and a simultaneous sense that he possessed a suprarational vision transcending the technical. Milken's spreadsheets help us to reconsider a central debate in the social studies of finance about the “ghost in the financial machine” and to examine the co-construction of “killer apps” and “killer applicants” in the early history of personal computing.
Analysis of climate and landscape change through the Pennsylvanian and Permian Monongahela and Dunkard Groups, Southeastern Ohio, USA

Paleosols and ichnofossils of the Late Pennsylvanian to Early Permian Monongahela and Dunkard groups of southeastern Ohio provide significant paleoenvironmental and paleoclimatic data related to the Late Paleozoic climatic transition. Forty paleosol profiles from three outcrops in southeastern Ohio were investigated. Methods included the description of paleosol profiles in the field and the analysis of thin sections. Clay mineralogy and bulk geochemistry were used to assess weathering processes and paleoprecipitation. Results, such as the distribution, abundance, and size of physical features including slickensides, pedogenic carbonates, and rhizoliths suggest erratic fluctuations between mildly seasonal wet environments and strongly seasonal dry environments throughout the studied section which are supported by oscillations in calculated paleoprecipitation values. Paleosols of the Monongahela Group are interpreted as mildly to strongly seasonal, wet to wet-dry, sparsely to heavily vegetated fen, dry woodland, clastic marsh, early successional vegetation, and brakeland ecosystems forming on proximal to distal floodplain and shoreline lacustrine environments. Paleosols of the Lower Dunkard Group are interpreted as a mildly to strongly seasonal, wet to wet-dry, sparsely to heavily vegetated, clastic marsh, early successional vegetation, and brakeland ecosystems forming on proximal to distal floodplain and distal levee environments. Variability in climate has profound effects on paleolandscapes. By investigating changes in paleosols through episodes of climatic transition, we can better understand the impact these changes have on soils and soil ecosystems of the past and future.
Reforming the Undergraduate Core Curriculum Through the Integration of Public Music Theory

Connecting with the broader public constitutes an integral part of many musicians' professional lives, and these skills are often first developed at the university level. In response, a growing contingent of scholars have published models for integrating community-focused activities into a theory curriculum, including Jenkins 2017, Bourne 2017, Peebles 2017 and Williams 2017. Our article extends these authors' work by suggesting three methods by which to carry out small-scale public music theory projects throughout the semester.
Ideological Focus, Tactical Performance, and the Survival of Terrorist Organizations

Organizations that have a clear focus acquire greater reputational legitimacy, which raises their capacity for mobilization. Using data on terrorist organizations, this paper explores two empirical implications of this claim: A terrorist organization’s survival and lethality will be threatened to the extent that it has an ambiguous identity. Analyses using panel data from the Extended Data on Terrorist Groups (EDTG) test these arguments for nearly 500 terrorist organizations observed over 1970-2016. The key empirical predictions are that ambiguity inhibits lethality and curtails survival. Moreover, ambiguity curtails a TO’s longevity most during the very early years of its operation, consistent with the liability of newness argument. This paper finds support for these claims, controlling for competition from rivals and allies, ethno-nationalist or Islamic ideological orientation, tactical diversity, size, international operations, and other measures of organizational capacity.
Septic Iliopsoas Bursitis After Intra-articular Methylprednisolone Injection to the Hip: A Case Report.

Case We describe the case of a 74-year-old man who developed severe hip pain several days after an intra-articular methylprednisolone injection to his right hip. Culture of the ipsilateral iliopsoas bursa revealed a Staphylococcus lugdunensis infection, which was successfully eradicated through irrigation and debridement as well as antibiotics. Conclusion Infection after hip injection is a known theoretical risk but is rarely reported in the literature. We present a case of septic bursitis after corticosteroid injection. Readers should be mindful that these complications do occur in clinical practice and portend significant morbidity.
Exploring COVID-19 Vaccine Hesitancy Among Stakeholders in African American and Latinx Communities in the Deep South Through the Lens of the Health Belief Model.

PurposeThe purpose of this study was to qualitatively explore perceptions related to COVID-19 vaccination intention among African American and Latinx participants and suggest intervention strategie...
WE-AB-BRA-11: Development of Physiological-Based Virtual Thorax Phantoms for Evaluation of Deformable Image Registration

Purpose: To develop a methodology of constructing physiological-based virtual thorax phantom based on hyperpolarized (HP) gas tagging MRI for evaluating deformable image registration (DIR). Methods: Three healthy subjects were imaged at both the end-of-inhalation (EOI) and the end-of-exhalation (EOE) phases using a high-resolution (2.5mm isovoxel) 3D proton MRI, as well as a hybrid MRI which combines HP gas tagging MRI and a low-resolution (4.5mm isovoxel) proton MRI. A sparse tagging displacement vector field (tDVF) was derived from the HP gas tagging MRI by tracking the displacement of tagging grids between EOI and EOE. Using the tDVF and the high-resolution MR images, we determined the motion model of the entire thorax in the following two steps: 1) the DVF inside of lungs was estimated based on the sparse tDVF using a novel multi-step natural neighbor interpolation method; 2) the DVF outside of lungs was estimated from the DIR between the EOI and EOE images (Velocity AI). The derived motion model was then applied to the high-resolution EOI image to create a deformed EOE image, forming the virtual phantom where the motion model provides the ground truth of deformation. Five DIR methods were evaluated using the developed virtual phantom. Errors in DVF magnitude (Em) and angle (Ea) were determined and compared for each DIR method. Results: Among the five DIR methods, free form deformation produced DVF results that are most closely resembling the ground truth (Em=1.04mm, Ea=6.63°). The two DIR methods based on B-spline produced comparable results (Em=2.04mm, Ea=13.66°; and Em =2.62mm, Ea=17.67°), and the two optical-flow methods produced least accurate results (Em=7.8mm; Ea=53.04°; Em=4.45mm, Ea=31.02°). Conclusion: A methodology for constructing physiological-based virtual thorax phantom based on HP gas tagging MRI has been developed. Initial evaluation demonstrated its potential as an effective tool for robust evaluation of DIR in the lung.
Detecting offensive routers: a straightforward approach

Packet dropping attack (PDA) is a network attack that utilizes compromised network elements to degrade network performance or quality by intentionally dropping a certain amount of IP packets. The major distinction of the PDA from traditional denial-of service (DoS) attack is that some victims do not even discern that they are under attack. Offensive router detection (ORD) is a mechanism capable of detecting offensive routers that are performing the PDA. The ORD mechanism is based on the principle of conservation of flow in the network, and employs a new proposed ICMP message, Caddie message, which records packet forwarding information in the Caddie messages. Therefore, after analyzing the information, we can identify routers that are abnormally dropping packets. We show the advantages of the ORD mechanism over other existing network monitoring mechanisms and discusses storage and bandwidth overhead issues. We also demonstrate the advantages and the effectiveness of the approach by simulating the functionality of the ORD mechanism to detect four different packet-dropping patterns.
Temporal and Atemporal Foresight1

The thesis of the following paper is that one's conception of foresight depends on his conception of man's cognitive nature and the systems in which man operates. Two decision theorists are contrasted, one a political scientist, the other an economist. It is alleged that one emphasizes the passive, reactive, outer-stimulated character of man's mind and the permanent, predictable character of the world he inhabits. The other allegedly emphasizes the active, spontaneous, autogenic character of man's mind and the changing, unpredictable character of his world. These pairs of conceptions lead to conceptions of foresight as respectively atemporal and temporal. Atemporal foresight is represented as calculation within a closed system, an essentially mechanical operation better performed by computers than by men. Temporal foresight is represented as creation within an open system, an essentially human operation performable only by the frontal lobe of the human cerebral cortex.
3‐Thenoic Acid

3-Thenoic acid product: 3-thenoic acid Keywords: oxidation, CHO CO2H; silver oxide, preparation
Micro-electromechanical systems and test results of SiC MEMS for high-g launch applications

Micro-electromechanical systems or MEMS are typically used for the measurement of physical phenomena associated with gun launched projectiles and other smart munitions. These devices generally experience not only the harsh environment encountered during initial shock and vibration at gun launch, but also the extremes of high temperature, high pressure and in some cases large electromagnetic fields associated with the launching mechanisms. This paper describes the various types of sensor requirements and characteristics for modern smart weapons, especially those of MEMS and in particular recent experimental results with silicon carbide MEMS pressure sensors.
Discrimination Between Sporothrix schenckii and Ceratocystis stenoceras Rhamnomannans by Proton and Carbon-13 Magnetic Resonance Spectroscopy

The proton and (13)C magnetic resonance (CMR) spectra of 10 Sporothrix schenckii and three Ceratocystis stenoceras rhamnomannans were studied. On the basis of their CMR spectra, the rhamnomannans from S. schenckii strains could be classified into two major types, I and II, readily distinguishable from the polysaccharides formed at the same temperature (25 C) by C. stenoceras. Rhamnomannans from S. schenckii synthesized at 37 C gave CMR spectra (type III) differing from those of polysaccharides of types I and II and from those of C. stenoceras polysaccharides. The contention that C. stenoceras might be the perfect form of S. schenckii is not supported by the present data. A presumptive pathogenic mutant of C. stenoceras synthesized a type I rhamnomannan characteristic of S. schenckii, clearly differing from the rhamnomannans from C. stenoceras synthesized in the same conditions. Nuclear magnetic resonance spectroscopy revealed differences in the structures of the polysaccharides from these species not previously recognized by methylation analysis.
A zero-one law for integral functionals of the bessel process

In this paper, we find necessary and sufficient conditions for the finiteness of the integral functionals of the Bessel process: ∝ o t f(Rs) ds, 0≤t<∞. They are in the form of a zero-one law and can be regarded as a counterpart of the They are in the form of a zero-one law and can be regarded as a counterpart of the Engelbert-Schmidt (1981) results, in the case of the Bessel process with dimension n≥2.
Dispersion characteristics in a magnetically gyrotropic medium

The dispersion characteristics of waves in a magnetically gyrotropic medium for an arbitrary direction of applied magnetic field are obtained. The resonance and cutoff frequencies are derived. The frequency regions where waves can or cannot propagate are investigated.
Modeling of an internal combustion engine for control analysis

Recent activity in nonthermodynamic modeling of automotive internal combustion engines with spark ignition, which are inherently nonlinear, is reviewed. A fundamental nonlinear model of the engine is presented, and a linear control-oriented model is derived from the nonlinear process. Techniques for experimental verification are examined, and a practical linear engine example incorporating multirate sampling is illustrated. >
Folding large regular computational graphs onto smaller processor arrays

Index Mapping is a novel approach to mapping a class of algorithms onto linear permutation networks such as the shuffle graph. This class includes the Viterbi Algorithm, the Fast Fourier Transform, and the Bitonic Sort, among others. With this technique, it is possible to analyze a large number of possible partitioning and scheduling schemes and choose for a given technology the optimum implementation. This technique will be demonstrated by two mappings of a variable and large constraint length Viterbi decoder onto a smaller fixed interconnection processing network with minimum hardware resources. The hardware built for this mapping can calculate the Viterbi algorithm for any constraint length from 3 to 15 with programmable code polynomials and code rates from 1/2 to 1/6.