cssi/SciSciGPT-SciSciNet huggingface dataset:
A case of butane hash oil (marijuana wax)-induced psychosis.

ABSTRACTBackground: Marijuana is one of the most widely used controlled substances in the United States. Despite extensive research on smoked marijuana, little is known regarding the potential psychotropic effects of marijuana “wax,” a high-potency form of marijuana that is gaining in popularity. Case: The authors present a case of “Mr. B,” a 34-year-old veteran who presented with profound psychosis in the setting of recent initiation of heavy, daily marijuana wax use. He exhibited incoherent speech and odd behaviors and appeared to be in a dream-like state with perseverating thoughts about his combat experience. His condition persisted despite treatment with risperidone 4 mg twice a day (BID), but improved dramatically on day 8 of hospitalization with the return of baseline mental function. Following discharge, Mr. B discontinued all marijuana use and did not exhibit the return of any psychotic symptoms. Discussion: This study highlights the need for future research regarding the potential medical and ps...
Under Water: Monitoring and Regulating Groundwater in California

California’s water supply system depends heavily on groundwater use, but its overuse threatens the reliability of the state’s future water availability. In our inaugural Pritzker Brief, Rhead Enion describes the importance of groundwater and the advantages of realigning California's water rights system to better manage groundwater. According to Under Water, the state should establish enforceable standards and goals for monitoring, data reporting and management of groundwater basins, to be implemented by regional and local entities. Under Water recommends, among other things: comprehensive groundwater monitoring, including groundwater use metering and groundwater quality screenings; the availability at a statewide level of monitoring data from regional and local agencies; and the implementation of statewide rules for regional regulation of groundwater, with mandatory management goals.
Preparation of Pillared Montmorillonite Supported Cabalt Catalysts

A series of Al-Pillared montmorillonite supported cobalt catalysts were prepared by ion-exchange and step-impregnation methods using Na-modified montmorillonite from Inner Mongolia Xinghe Bentonite.They were characterized by XRD and TPR techniques.The results showed that the active component was easier to load on the supports using impregnation method than ion-exchange method.Moreover,the impregnation times and impregnation order influenced the dispersion degree and reductive behavior of cobalt on the Al-Pillared montmorillonite supported cobalt catalysts.
Recurrent Transitional Cell Carcinoma in an Ileal Conduit Treated by Sandwich Chemotherapy and Surgical Resection

Abstract Recurrent transitional cell carcinoma in a ureteroileal conduit following radical cystectomy is rare. The prognosis for these patients is uniformly poor. We report on a patient with transitional cell carcinoma in an ileal conduit treated by chemotherapy and partial excision of the ileal conduit. He was without evidence of disease 4½ years after completion of therapy.
Feeding Responses of Honeybees in the Hive

SummaryHoneybees in their hive were more strongly attracted to a sugar paste containing pollen than to a sugar paste alone; pollens differed in their attraction for these bees. Some of the attractive substances were soluble in chloroform, methanol and/or water, but the whole pollen of Melilotas alba was more attractive than its chloroform-methanol extract; the chloroform-methanol extract of the same pollen was more attractive than the water extract. The comparatively poor response of bees to unextracted pollen of Echium lycopsis (plantagineum) and to a chloroform-methanol extract of this pollen is discussed.
Device design requirements for MOS analog circuits

The past decade has seen MOS technology advance from 6 micron to below 2 micron design rules, yielding a large increase in the level of integration. Both technology and device designs have followed souse simple scaling rules to achieve high density [1], These advancements have predominantly been driven by the needs of memory, especially Dynamic RAH, How that circuit applications have become greatly diversified, the D-RAM driven approach Is no longer an effective one. We believe that future technology and device designs should address specific circuit needs. The device design issues are examined In this paper. In this paper, we present a hierarchical framework for evaluating the Impact of various device design parameters on the performance of HOS circuits. In order to present this framework, we will define various circuit classifications and the circuit parameters which are most important for that particular application. Next, we will use as an example of the framework, the optimization of device design for analog circuits specifically addressing the circuit performance parameters of gain, bandwidth, signal swing and noise.
In vivo imaging of activity in targeted cell populations in the mouse olfactory bulb

Genetically encoded voltage indicators can be used to optically monitor activity of distinct populations of neurons. Our goal was to target ArcLight to mitral/tufted cells in the olfactory bulb, and measure their response to odorants.
Information conservational YinYang Bipolar quantum-fuzzy cognitive maps - mapping business data to business intelligence

Based on YinYang bipolar fuzzy sets and bipolar quantum linear algebra (BQLA), information conservational bipolar quantum-fuzzy cognitive maps (BQFCMs) are proposed. It is shown that a relational BCM can be normalized to a bipolar quantum-fuzzy logic gate (BQFLG) matrix - the equivalent of a BQFCM for equilibrium-based business intelligence. Computability and applicability of BQFCMs are illustrated with case studies in portfolio management, supply-production optimization and import- export rebalancing. This work is expected to add bipolar quantum computational intelligence (QCI) as an integrative dimension to computational intelligence. Its philosophical and mathematical uniqueness is discussed. An unsettled debate is outlined.
Microbiological Analysis of Alligator ( Alligator mississippiensis ) Meat.

The two tail muscles, ilio caudalis and ischio caudalis, along with hide surface areas from four alligators, Alligator mississippiensis , were evaluated for microbial numbers and types. Microbial analyses of hide surfaces yielded a mean aerobic plate count (APC, 35 C) of approximately 4.45 logs/cm2 at 35 C, and total coliform counts were low. Salmonella was not recovered from hide or tissue samples. APCs of fresh meat samples were low (2.88 - 3.02 logs/g) regardless of muscle type, with no recovery of fecal coliforms or Escherichia coli . Microbial development in meat stored at 1.7 C for up to 15 days was comparable to that reported for fresh beef. Typical microorganisms recovered included Corynebacterium , Staphylococcus , Micrococcus , Flavobacterium , Pseudomonas , Acinetobacter , Arthrobacter and yeasts.
Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats.

Background/objectives The combination of energy dense diets and reduced energy expenditure in modern society has escalated the prevalence of obesity and obesity-related comorbidities. Among these disease states, type-2 diabetics (T2D) are disproportionately associated with obesity, suggesting a shared etiology. In conjunction with defects in hormonal and inflammatory states, obesity and T2D are also characterized by dysbiosis. Methods We have recently described the beneficial effects of duodenal nutrient exclusion, as induced by the duodenal endoluminal sleeve (DES); including body weight loss, prevented fat mass accumulation, and improved glucose tolerance in the ZDF rat, a rodent model of obesity and type-2 diabetes (T2D). To assess the relative role of DES on hindgut microbiota in the context of these metabolic changes, we analyzed cecal samples from rats implanted with a duodenal endoluminal sleeve (DES), or a sham control of this procedure. A group of pair-fed (pf) sham controls was also included to account for changes induced by reduced body weight and food intake. Results Analysis of hindgut microbiota following DES in the ZDF rat elucidated discrete changes in several microbial populations including a reduction in Paraprevotella family members of the Clostridiales order along with an increase in Akkermansia muciniphila and species of the Allobaculum and Bifidobacterium genera. Conclusions Altogether, these observations suggest that like Roux-en Y gastric bypass (RYGB) and Metformin, regulation of gut microbiota may be a contributing factor to the therapeutic effects of DES.
High-speed and high-resolution quantitative phase imaging with digital-micromirror device-based illumination (Conference Presentation)

Due to the large number of available mirrors, the patterning speed, low-cost, and compactness, digital-micromirror devices (DMDs) have been extensively used in biomedical imaging system. Recently, DMDs have been brought to the quantitative phase microscopy (QPM) field to achieve synthetic-aperture imaging and tomographic imaging. Last year, our group demonstrated using DMD for QPM, where the phase-retrieval is based on a recently developed Fourier ptychography algorithm. In our previous system, the illumination angle was varied through coding the aperture plane of the illumination system, which has a low efficiency on utilizing the laser power. In our new DMD-based QPM system, we use the Lee-holograms, which is conjugated to the sample plane, to change the illumination angles for much higher power efficiency. Multiple-angle illumination can also be achieved with this method. With this versatile system, we can achieve FPM-based high-resolution phase imaging with 250 nm lateral resolution using the Rayleigh criteria. Due to the use of a powerful laser, the imaging speed would only be limited by the camera acquisition speed. With a fast camera, we expect to achieve close to 100 fps phase imaging speed that has not been achieved in current FPM imaging systems. By adding reference beam, we also expect to achieve synthetic-aperture imaging while directly measuring the phase of the sample fields. This would reduce the phase-retrieval processing time to allow for real-time imaging applications in the future.
Time to first occurrence of breast pain and vaginal bleeding in phase 3 trials of CE/BZA.

OBJECTIVE In studies of the menopausal therapy, conjugated estrogens/bazedoxifene, breast pain and vaginal bleeding rates were comparable to placebo and lower than conjugated estrogens/medroxyprogesterone acetate (MPA). This post hoc analysis determined median time to occurrence of these events. METHODS Participants in phase 3 conjugated estrogens/bazedoxifene trials recorded breast pain and vaginal bleeding in daily diaries. Median time to first incident was determined in women taking conjugated estrogens 0.45 mg/bazedoxifene 20 mg, conjugated estrogens 0.625 mg/bazedoxifene 20 mg, placebo, and conjugated estrogens 0.45 mg/MPA 1.5 mg (active control in Selective estrogens, Menopause, And Response to Therapy [SMART]-5 trial). We included on-treatment data (12 weeks-2 years) in healthy postmenopausal women (SMART-1), those seeking treatment for menopausal symptoms (SMART-5), and those with moderate/severe vasomotor symptoms (SMART-2). Analyses were performed using SAS Proc Lifetest. RESULTS With conjugated estrogens/MPA as comparator, median time to breast pain was 299 days for conjugated estrogens/MPA, 353 for placebo, and more than 365 (median not reached) for conjugated estrogens 0.45 mg/bazedoxifene 20 mg and conjugated estrogens 0.625 mg/bazedoxifene 20 mg. Median time to vaginal bleeding was 314, 341, 357, and 362 days, respectively. Breast pain and vaginal bleeding survival curves were not significantly different for conjugated estrogens/bazedoxifene and placebo in any study, but were (P < 0.0001) when conjugated estrogens/MPA was added to the sample in SMART-5. CONCLUSIONS The time course of breast pain and vaginal bleeding with conjugated estrogens/bazedoxifene was similar to that of placebo during treatment for up to 2 years. Events occurred significantly earlier with conjugated estrogens/MPA versus conjugated estrogens/bazedoxifene or placebo.
Sedimentology of Colour Lake, a Nonglacial High Arctic Lake, Axel Heiberg Island, N.W.T., Canada

The sedimentary characteristics, both past and present, of a small, nonglacial lake (i.e. a lake that does not presently receive significant quantities of glacial meltwater and sediment) in the Can...
Techniques and behaviors associated with exemplary inpatient general medicine teaching: an exploratory qualitative study

Background Clinician educators face numerous obstacles to their joint mission of facilitating high-quality learning while also delivering patient-centered care. Such challenges necessitate increased attention to the work of exemplary clinician educators, their respective teaching approaches, and the experiences of their learners. Objective To describe techniques and behaviors utilized by clinician educators to facilitate excellent teaching during inpatient general medicine rounds. Design An exploratory qualitative study of inpatient teaching conducted from 2014 to 2015. Setting Inpatient general medicine wards in 11 US hospitals, including university-affiliated hospitals and Veterans Affairs medical centers. Participants Participants included 12 exemplary clinician educators, 57 of their current learners, and 26 of their former learners. Measurements In-depth, semi-structured interviews of exemplary clinician educators, focus group discussions with their current and former learners, and direct observations of clinical teaching during inpatient rounds. Results Interview data, focus group data, and observational field notes were coded and categorized into broad, overlapping themes. Each theme elucidated a series of actions, behaviors, and approaches that exemplary clinician educators consistently demonstrated during inpatient rounds: (1) they fostered positive relationships with all team members by building rapport, which in turn created a safe learning environment; (2) they facilitated patient-centered teaching points, modeled excellent clinical exam and communication techniques, and treated patients as partners in their care; and (3) they engaged in coaching and collaboration through facilitation of discussion, effective questioning strategies, and differentiation of learning among team members with varied experience levels. Conclusions This study identified consistent techniques and behaviors of excellent teaching during inpatient general medicine rounds.
Perspectives of Title IX Pioneers: Equity, Equality and Need

The purpose of the study was to analyze the perspectives of Title IX trailblazers noting changes over a 40-year span as identified by participating Mountain West Conference athletic departments. Questions posed to participants focused on Title IX’s impact on participants, their personal contributions to gender equity, and how athletic departments have committed to gender equity over the past 40 years by supporting opportunities for women in athletics. Participants were recruited directly by their respective MWC school, and agreed to be videotaped for a MWC production shared publicly and submitted for a national competition. Video recordings were transcribed and analyzed. From the transcripts a coding system was developed to identify themes and concepts. Coding was undertaken through comparative analysis and in line with the two part process identified by Charmaz (2006). The data were evaluated using the theoretical framework of distributive justice to view women’s experiences in intercollegiate athletics over the 40 year period of Title IX implementation (Mahony & Pastore, 1998). This theoretical grounding was used to illuminate ways in which resource decisions are made which often disadvantage women, and to examine the perceptions of fairness based on equity, equality and need (Mahony & Pastore, 1998) within athletic departments. The integration of the distributive justice framework in the data analysis illuminates the power differentials as well as the challenges women have faced in intercollegiate athletics directly attributable to Title IX. Analysis of the videos compiled revealed three primary themes, 1) Eras / generational differences, 2) Fighting for resources, and 3) Leadership and life skills development, along with several subthemes. Discussion of key themes and the resulting implications are presented.
Quantification and Determination of Normal 123I-Meta Iodobenzylguanidine Heart-to-Mediastinum Ratio (HMR) from Cardiac SPECT/CT and Correlation with Planar HMR

Assessment of cardiac 123I-meta iodobenzylguanidine (123I-mIBG) uptake relies on the heart-to-mediastinum ratio (HMR) derived from planar images. We have developed novel semiautomated quantitative methodologies for assessing HMR from SPECT images using a dedicated cardiac multipinhole SPECT/CT system and determined the lower limit of normal (LLN) SPECT-derived HMR and the correlation to planar-derived HMR. Methods: Twenty-one healthy volunteers were injected with 123I-mIBG and imaged using 2 different cameras. Planar images were acquired using a conventional SPECT camera equipped with parallel hole collimators, and hybrid SPECT/CT images were acquired using a dedicated cardiac SPECT system with 19 pinhole collimators interfaced with 64-slice CT. Planar HMR was calculated as per standard guidelines (manual traditional method) and elliptic region-of-interest (Elip-ROI) and region-growing (RG-ROI) techniques. SPECT HMR was quantified using a new method that incorporates various cardiac and mediastinal segmentation schemes in which upper and lower limits of the heart were determined from CT and the left ventricular ROI, and mean counts were calculated using Elip-ROI and RG-ROI techniques. Mean counts in mediastinal ROI were computed from a fixed volume in 3 different regions: upper mediastinum (UM), lower mediastinum (LM), and contralateral lung (CL). HMRs were processed by 2 observers, and reproducibility was assessed by intraclass correlation coefficient and Bland-Altman analysis. Results: Planar HMR calculated using the RG-ROI method showed highest intra- and interobserver levels of agreement compared with Elip-ROI and manual traditional methods. SPECT HMR calculated on the basis of UM, LM, and CL background regions showed excellent intra- and interobserver agreement. SPECT HMR with UM resulted in highest correlation (R = 0.91) with planar HMR compared with that with LM (R = 0.74) and CL (R = 0.73). The LLN of SPECT HMR with UM and that of planar HMR was calculated as 5.5 and 1.6, respectively. The normal values of SPECT-derived HMR and planar-derived HMR were correlated linearly. Conclusion: We reconfirmed the previous planar HMR threshold and determined SPECT LLN HMR for SPECT. Planar HMR can be estimated from SPECT HMR via a simple linear regression equation, allowing use of the new cardiac-dedicated SPECT camera for 123I-mIBG imaging.
Safety of Oral Dofetilide Reloading for Treatment of Atrial Arrhythmias.

Background: Although dofetilide labeling states that the drug must be initiated or reinitiated with continuous electrocardiographic monitoring and in the presence of trained personnel, the risks of dofetilide reloading justifying repeat hospitalization have not been investigated. Methods and Results: Patients admitted for dofetilide reloading for atrial arrhythmias were retrospectively reviewed. The need for dose adjustment and the incidence of torsades de pointes (TdP) were identified. The incidence of TdP in dofetilide reloading was compared with patients admitted for dofetilide initial loading. Of 138 patients admitted for dofetilide reloading for atrial arrhythmias, 102 were reloaded at a previously tolerated dose, 30 with a higher dose from a previously tolerated dose and 2 at a lower dose; prior dosage was unknown in 4 patients. Dose adjustment or discontinuation was required in 44 patients (31.9%). No TdP occurred in the same dose reloading group, but TdP occurred in 2 patients admitted to increase dofetilide dosage (0% versus 6.7%; P =0.050). Dofetilide dose adjustment or discontinuation was required in 30 of 102 patients (29.4%) reloaded at a previously tolerated dose and in 11 of 30 patients (36.7%) admitted for an increase in dose. Conclusions: Although no TdP occurred in patients admitted to reload dofetilide at the same dose as previously tolerated, dosage adjustments or discontinuation was frequent and support the need for hospitalization for dofetilide reloading. Patients admitted for reloading with a higher dose tended to be at higher risk for TdP than patients reloaded at a prior tolerated dose.
Competing Motives for CSR: Identification Through Peer Group Selection

This study examines firm strategic motivations to engage in corporate social responsibility (CSR) through the lens of peer effects. The concept of CSR has long intrigued management scholars; the li...
Imaging findings of recurrent pancreatic cancer following resection.

Pancreatic cancer is a challenging malignancy to treat, largely due to aggressive regional involvement, early systemic dissemination, high recurrence rate, and subsequent low patient survival. Generally, 15–20% of newly diagnosed pancreatic cancers are candidates for possible curative resection. Eighty percent of these patients, however, will experience locoregional or distant recurrence in first 2 years. Although there is no strong evidence-based guideline for optimal surveillance after pancreatic cancer resection, careful comparison of surveillance follow-up multi-detector CT (MDCT) studies with a postoperative baseline MDCT examination aids detection of early recurrent pancreatic cancer. In this review article, we describe imaging findings suggestive of recurrent pancreatic cancer and review routine and alternative imaging options.
Exploring virtual reality as a platform for distance team-based learning.

Abstract Background and purpose Online distance education has become popular in pharmacy education, but it can be challenging to provide engaging experiences such as team-based learning (TBL) in this format. This study explored the utility of virtual reality (VR) as a platform to provide the engaging elements of TBL, without students needing to be physically present in the same room. Educational activity and setting Volunteers participated in a modified TBL exercise in VR, followed by a survey of the experience. The survey included Likert-type questions to evaluate the level of immersion and perceived engagement, comfort and desirability of VR-TBL experiences. Findings and discussion The majority of the responses to the 14-question survey were ‘agree’ or ‘strongly agree’. Ninety-four percent (94.4%) of participants strongly agreed that this was a fun experience, and 94.4% of participants strongly agreed that they would take a course in this format if it was offered. Although none of the questions received a majority of ‘disagree’ or ‘strongly disagree’ responses, areas for improvement included ease of use of the technology, comfort and improving the learning activity. Summary The response of participants to this study was positive and the overall conclusion was that VR has the potential to be a useful tool for online, distance TBL, and should be explored further.
Demonstration of a Heterogeneously Integrated System-on-Wafer (SoW) Assembly

This paper describes the integration of a System-on-Wafer (SoW) assembly using test dielets mounted on a Silicon Interconnect Fabric (Si-IF) with an inter-dielet spacing of 100 µm and using 10 µm interconnect pitch. The continuity within and across the dielet assembly is shown using daisy chains of Au-capped Cu-Cu thermal compression bonds. The daisy chains run not only through every dielet but also across all the adjacently mounted dielets on the Si-IF. The interconnections exhibited an effective contact resistivity of 0.8-0.9 ?-µm2 and an average shear strength of 125 MPa. Our investigations showed that Argon plasma pre-treatment improves the shear strength of the metal bonds by a factor of 5X. Thermal simulation of the SoW assembly showed superior heat spreading across the assembly in a checkerboard configuration of alternate hot (0.5 W/mm2) and cold (0.1 W/mm2) dielets with an average temperature of 82 °C & 78 °C respectively.
Active Fault Identification by Optimization of Test Designs

Model-based fault detection and isolation (FDI) methods are used to determine faults by examining the deviation of sensed information from anticipated system trajectories. In this paper, a comprehensive model-based FDI framework is proposed to improve fault identifiability and reduce false alarms during maintenance testing. In this framework, robust maintenance tests are designed and conducted, followed by false alarm analysis. The optimal tests designed improve the identifiability of faults by manipulating system inputs to maximize information with respect to faults, in the form of sensitivities of the system outputs. Each test design is evaluated a posteriori using the system model to explore whether false alarms are plausible, given system uncertainty and measurement noise. The proposed framework is applied on two case studies that compare the identifiability of faults at nominal and optimal system test conditions. The first case study focuses on a plate fin heat exchanger with various levels of particulate fouling at steady-state and transient conditions. The second case study deals with the same type of fault but in an aircraft environmental control system with multiple sources of uncertainty.
Time-frequency BSS of biosignals

Time–frequency (TF) representations are very important tools to understand and explain circumstances, where the frequency content of non-stationary signals varies in time. A variety of biosignals such as speech, electrocardiogram (ECG), electroencephalogram (EEG), and electromyogram (EMG) show some form of non-stationarity. Considering Priestley's evolutionary (time-dependent) spectral theory for analysis of non-stationary signals, the authors defined a TF representation called evolutionary Slepian transform (EST). The evolutionary spectral theory generalises the definition of spectra while avoiding some of the shortcomings of bilinear TF methods. The performance of the EST in the representation of biosignals for the blind source separation (BSS) problem to extract information from a mixture of sources is studied. For example, in the case of EEG recordings, as electrodes are placed along the scalp, what is actually observed from EEG data at each electrode is a mixture of all the active sources. Separation of these sources from a mixture of observations is crucial for the analysis of recordings. In this study, they show that the EST can be used efficiently in the TF-based BSS problem of biosignals.
Robotic Pulmonary Lobectomy and Segmentectomy

Thoracic surgery has evolved since the initial published reports of pulmonary lobectomy by Drs. Norman Shenstone and Robert Janes from the Toronto General Hospital, in which they describe “a long incision... In the general direction of the ribs, passing just below the scapula,” or via a thoracotomy (Shenstone and Janes, Can Med Assoc J 27: 138–45, 1932). Since then, surgeons have found ways to improve on minimally invasive options thereby optimizing postoperative morbidity, recovery time, and pain. Minimally invasive lobectomy has traditionally been performed using video-assisted thoracoscopic surgery (VATS) techniques. The first robotic lobectomies were reported in 2003 by Morgan et al. and Ashton et al. (Morgan et al. Eur J Cardiothorac Surg 23: 883-7, 2003; Ashton et al. J Thorac Cardiovasc Surg 126: 292–3, 2003). Since then, the use of robotic technology for lobectomy has become increasingly common. In 2015, over 6000 robotic lobectomies were performed in the United States, and over 8600 done worldwide.
Deficiency One Theory Foundations

This chapter has two goals. First, we want to provide not only a proof of the Deficiency One Theorem but also a guide to the thinking behind the proof. Another salt theorem, motivated by the same salt-barrel picture met in the last chapter, will play a crucial role. Second, we want to elaborate more fully on the so-called Deficiency One Algorithm described in Section 8.5. The algorithm itself will be laid out in far more detail, and its theoretical underpinnings will be explained. In this, the salt-barrel picture will find use yet again.
Rate Coefficients for the Gas-Phase Reaction of ( E)- and ( Z)-CF3CF═CFCF3 with the OH Radical and Cl-Atom.

The rate coefficients, k, for the gas-phase reaction of the OH radical and Cl-atom with (E)- and (Z)-CF3CF═CFCF3 were measured using a relative rate technique over a range of temperature (240–375 K...
Expectations and Experiences of Latina and Anglo Girls and Parents for Life After High School

This study investigated whether Latina youth in special education and parents of Latinas in special education differ from their Anglo counterparts regarding transition expectations and experiences, and experiences of self-determination. Surveys were completed by 211 transition-aged Anglo and Latina females, and parents of Anglo girls and Latinas in two school districts. Participants generally agreed on transition goal importance; however, caring for family members and spirituality were more valued by Latina girls. Parents of Latinas placed greater emphasis on their daughters working and attending college, in comparison to parents of Anglo youth. Implications considered include the need to further explore stereotypes regarding the transition goals of Latina youth and families, and to provide culturally-tailored transition supports.
TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis

In the analysis of high-throughput data from complex samples, cell composition is an important factor that needs to be accounted for. Except for a limited number of tissues with known pure cell type profiles, a majority of genomics and epigenetics data relies on the “reference-free deconvolution” methods to estimate cell composition. We develop a novel computational method to improve reference-free deconvolution, which iteratively searches for cell type-specific features and performs composition estimation. Simulation studies and applications to six real datasets including both DNA methylation and gene expression data demonstrate favorable performance of the proposed method. TOAST is available at https://bioconductor.org/packages/TOAST .
Everyday Relevancy in Gurwitsch and Schutz

Relevance (or relevancy) is used from the beginning to the end of Schutz’s research and a convergent notion is independently advocated by his friend Aron Gurwitsch. Thematic-relevance and ego-relevance can thus be spoken of and study of the analyses offered by the two friends shows that they are not only compatible but complementary.
UAS Platforms and Applications for Mapping and Urban Analysis

The use of unmanned aerial systems (sUAS) is growing rapidly. sUAS are used in a wide range of applications, including emergency response, law enforcement, infrastructure inspection and management, as well as mapping and surveying. In this chapter, we provide an overview of sUAS platforms and discuss many different applications of sUAS in urban (or near urban) settings, from public health to cargo transport and delivery. Readers should consider this chapter a thorough, but not all-encompassing, literature review on sUAS for urban applications.
Landscape of coexisting excitonic states in the insulating single-layer cuprates and nickelates

We present an ab initio study of the excitonic states of a prototypical high-temperature superconductor ${\mathrm{La}}_{2}{\mathrm{CuO}}_{4}$ and compare them to the isostructural single-layer nickelate ${\mathrm{La}}_{2}{\mathrm{NiO}}_{4}$. A key difference in the low-energy electronic structure leads to very different excitonic behavior. Excitons in ${\mathrm{La}}_{2}{\mathrm{CuO}}_{4}$ are delocalized and can freely move in the ${\mathrm{CuO}}_{2}$ plane without disturbing the antiferromagnetic order. In contrast, in ${\mathrm{La}}_{2}{\mathrm{NiO}}_{4}$, we find the low-lying excitonic states to be extremely localized, producing a nearly flat dispersion. The theoretically obtained excitonic dispersion and behavior are in excellent agreement with RIXS observations. To classify the excitons, we project the electron-hole coupling onto each atomic site including the full manifold of atomic orbitals. We find the excitons to be composed of a linear combination of exciton classes, including Mott-Hubbard, $d\text{\ensuremath{-}}d$, and charge-transfer. The implication of these excitations to the high-${T}_{c}$ pairing mechanism is also discussed.
Introduction: Overview and Challenges of Cognitive and Behavioral Assessment

Through the collection of extensive amounts of computerized clinical and investigative information, I have always valued the data-driven approach that can be derived from registries. It is a more accurate method that can be viewed as a way of spawning hypotheses that are more likely to be worth investigating further, rather than hypotheses based primarily on intuition. What follows is hypothesis-driven research. Through the biological model of stroke, I have studied the type and nature of cognition in stroke through four separate digitized cognitive stroke registries in a sojourn through six different academic centers in three different countries (South Africa, USA, Canada). Stroke patients are particularly instructive as the deficits present relatively suddenly; they are frequently dramatic (imitation behavior, anosognosia) yet often resolve spontaneously. The inordinately rich nature of cognitive and behavior impairment syndromes, conjure up both a fascination of brain functioning but also have important treatment and management consequences for clinical brain disorders. For example, it has long confounded clinicians that the almost universally successful animal studies in stroke have all failed in humans without exception. This is despite over several decades worth of clinical trials in cerebrovascular disease. My own firm conviction, based on the research of these aforementioned digitized registries, is that our rudimentary and often nonexistent documentation of higher cortical functions in stroke is to blame. We know that approximately 90% of the brain has to do with higher order cognitive function, yet we pay penurious attention to these capacities in our clinics and in human clinical trials.
Linear Stokes measurement of thermal targets using compact LWIR spectropolarimeter

The trade-off between spectral resolution and instrument throughput is analyzed for a compact, uncooled, longwave infrared (LWIR) channeled spectropolarimeter (IRCSP). The IRCSP was developed as a part of the Sub-mm Wave and InfraRed Polarimeters (SWIRP) project out of NASA's Goddard Spaceflight Center. The IRCSP scientific objective targets measurements of AOLP and DOLP with 1-µm spectral resolution from 8.5 - 12.5µm in a single snapshot. The geometry of the field stop determines the field of view (FOV) of the IRCSP. This work relates the spectral resolution, instrument throughput, and polarimetric accuracy of a spectro-polarimeter to the FOV. The accuracy of linear Stokes retrievals for low temperature thermal targets are predicted for varying FOV and measurement noise conditions. This work presents a method to quantify the achievable accuracy in AOLP and DOLP as a function of field stop dimensions and signal-to-noise ratio (SNR). While smaller field stops are shown to improve accuracy as the spectral resolution is increased, low SNR is the dominant source of error for the IRCSP prototype. For the IRCSP, a SNR of at least 80 is required to produce DOLP measurements with < 5% error for targets with DOLP < 0.2.
Venetoclax-based chemotherapy in acute and chronic myeloid neoplasms: literature survey and practice points

Venetoclax (VEN), a small-molecule inhibitor of B cell leukemia/lymphoma-2, is now FDA approved (November 2018) for use in acute myeloid leukemia (AML), specific to newly diagnosed elderly or unfit patients, in combination with a hypomethylating agent (HMA; including azacitidine or decitabine) or low-dose cytarabine. A recent phase-3 study compared VEN combined with either azacitidine or placebo, in the aforementioned study population; the complete remission (CR) and CR with incomplete count recovery (CRi) rates were 28.3% and 66.4%, respectively, and an improvement in overall survival was also demonstrated. VEN-based chemotherapy has also shown activity in relapsed/refractory AML (CR/CRi rates of 33–46%), high-risk myelodysplastic syndromes (CR 39% in treatment naive, 5–14% in HMA failure), and blast-phase myeloproliferative neoplasm (CR 25%); in all instances, an additional fraction of patients met less stringent criteria for overall response. Regardless, venetoclax-induced remissions were often short-lived (less than a year) but long enough to allow some patients transition to allogeneic stem cell transplant. Herein, we review the current literature on the use of VEN-based combination therapy in both acute and chronic myeloid malignancies and also provide an outline of procedures we follow at our institution for drug administration, monitoring of adverse events and dose adjustments.
Exalloanthum, a new name for a fossil angiosperm flower in Myanmar amber

In a recent article, a flower from Burmese amber was described as Diaphoranthus burmensis. It was later discovered that the genus Diaphorathus Meyen had been used previously for an asterid, Diaphoranthus fuscus (Meyen 1834). The new name for Diaphoranthus burmensis is changed below to Exalloanthum burmense.
Association Between Rotator Cuff Tears and Superior Migration of the Humeral Head: An MRI-Based Anatomic Study

Background:Superior humeral migration has been established as a component of rotator cuff disease, as it disrupts normal glenohumeral kinematics. Decreased acromiohumeral interval (AHI) as measured...
Defective viral DNA in Epstein-Barr virus-associated oral hairy leukoplakia.

Abstract Defective Epstein-Barr virus (EBV) has a deleted and rearranged genome (termed het DNA) that disrupts latency and induces standard EBV to replicate in vitro. We used the polymerase chain reaction to detect, in 2 of 10 patient samples, the junction of abnormally juxtaposed EBV DNA fragments BamHI W and Z, a genomic rearrangement responsible for the biologic activity of het DNA. By sequence analysis, the junction in wild-type defective DNA appears to be similar but not identical to the recombination in the DNA of laboratory strain P3HR-1. The presence of this marker for het DNA in the epithelial lesions of two patients suggests a role for defective EBV in a human pathologic process.
Innovation by Policy: A Study of the Electronic Passport

The Congressional mandate for biometric and electronic passports puts political goals ahead of technical feasibility, creating what has been called a "loser system."
Synthesis of carbon-11 labeled fluorinated 2-arylbenzothiazoles as novel potential PET cancer imaging agents.

Abstract Fluorinated 2-arylbenzothiazoles are new potential antitumor drugs, which show potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Carbon-11 labeled fluorinated 2-arylbenzothiazoles may serve as novel probes for positron emission tomography (PET) to image tyrosine kinase in cancers. The preparation of 4-fluorinated 2-arylbenzothiazoles 4-fluoro-2-(3-benzloxy-4-methoxyphenyl)benzothiazole ( 6a ) and 4-fluoro-2-(3,4-dimethoxyphenyl)benzothiazole ( 6b ) was achieved by a modification of Jacobson thioanilide radical cyclization chemistry. Hydrogenolytic cleavage of the benzyl ether group of compound 6a using H 2 /Pd–C provided the precursor 4-fluoro-2-(3-hydroxy-4-methoxyphenyl)benzothiazole ( 7) for radiolabeling. Synthesis of radiolabeling precursors and the reference standards 5- and 6-fluorinated arylbenzothiazoles ( 11c–n ) was achieved via the reaction of o -aminothiophenol disulfides with substituted benzaldehydes under reducing conditions. The target radiotracers carbon-11 labeled 4-, 5-, and 6-fluorinated arylbenzothiazoles (3-[ 11 C] 6b , 4-[ 11 C] 11c , 3-[ 11 C] 11c , 5-[ 11 C] 11f , 4-[ 11 C] 11f , 4-[ 11 C] 11i , 3-[ 11 C] 11i , 5-[ 11 C] 11l , and 4-[ 11 C] 11l ) were prepared by O -[ 11 C]methylation of the phenolic hydroxyl precursors ( 7 , 11d , 11e , 11g , 11h , 11j , 11k , 11m , and 11n ) with [ 11 C]methyl triflate and isolated by solid-phase extraction (SPE) purification in 30–55% radiochemical yields.
Sound radiation properties of dielectric elastomer electroactive polymer loudspeakers

Dielectric elastomer electroactive polymer (EAP) loudspeakers have been built and demonstrated at SRI International. Dielectric elastomer loudspeakers have the advantages of being very lightweight and able to conform to any shape or surface, making them attractive as low-profile, surface-mounted speakers in rooms or vehicle interiors, and for applications in active noise control. Loudspeaker performance depends on a number of mechanical factors, such as speaker shape and mechanical bias, as well as on electrical driving characteristics. This paper discusses important aspects of loudspeaker performance, including sound pressure level and directivity.
Absolute measurement of the rates of radical exit and of radical-pair intersystem crossing in anionic micelles

Abstract The photoreduction of benzophenone by 1,4-cyclohexadiene has been examined in sodium dodecyl sulfate micelles. The triplet radical pair undergoes intersystem crossing with kISC = 5.8 × 106 s−1 at zero magnetic field; under these conditions 43% of the radical pairs separate via micellar exit processes.
"Protease I" of Escherichia coli functions as a thioesterase in vivo.

Escherichia coli protease I is assayed as an esterase active with certain synthetic model chymotrypsin substrates. However, the gene encoding protease I has the same DNA sequence and genomic location as tesA, a gene that encodes E. coli thioesterase I. We report that both hydrolase activities utilize the same active site and demonstrate that the protein functions as a thioesterase in vivo.
Periodic Structure in "Song of Myself "

Explores the nuances of Whitman's strategy of "expansion and contraction of consciousness within 'Song of Myself'" and situates the motif within the larger literary and historical context of the American Renaissance as proposed by F. O. Matthiessen.
Synthesis of 4-thiamethionine and its effect on energy metabolism and amino acid incorporation into protein of Ehrlich ascites tumour cells.

Abstract The methionine analog, 4-thiamethionine, was synthesized and found to be an inhibitor of incorporation of several amino acids into Ehrlich ascites protein in vitro . The inhibition was not prevented by methionine. Glutathione prevented the inhibition but could not bring about a reversal once the block was initiated. Glucose both prevented and reversed the inhibition, thus indicating that 4-thiamethionine interfered with the oxidative energy supply supporting protein synthesis.
Synchronous communication protocols for local networks

Abstract We propose protocols for the synchronous transmission of voice packets in local area networks. Two network models are considered: an all-voice network and a mixed voice and data network. The performance of the protocols is evaluated via simulation for these two network models.
Scalar dissipation rates in non-conservative transport systems.

Abstract This work considers how the inferred mixing state of diffusive and advective–diffusive systems will vary over time when the solute masses are not constant over time. We develop a number of tools that allow the scalar dissipation rate to be used as a mixing measure in these systems without calculating local concentration gradients. The behavior of dissipation rates is investigated for single and multi-component kinetic reactions and a commonly studied equilibrium reaction. The scalar dissipation rate of a tracer experiencing first-order decay can be determined exactly from the decay constant and the dissipation rate of a passive tracer, and the mixing rate of a conservative component is not the superposition of the solute specific mixing rates. We then show how the behavior of the scalar dissipation rate can be determined from a limited subset of an infinite domain. Corrections are derived for constant and time dependent limits of integration the latter is used to approximate dissipation rates in advective–diffusive systems. Several of the corrections exhibit similarities to the previous work on mixing, including non-Fickian mixing. This illustrates the importance of accounting for the effects that reaction systems or limited monitoring areas may have on the inferred mixing state.
Radiometric assay for minute quantities of L-fucose.

Abstract A radiometric assay has been developed for l -fucose which is capable of measuring quantities of this deoxysugar as low as 25 pmol. The assay couples l -fucose dehydrogenase to l -glutamate dehydrogenase and l -glutamate decarboxylase to yield radioactive CO2 which is collected and counted as a measure of l -fucose content. The assay eliminates high backgrounds observed with fluorescence assays.
THe Horror Film in Neoconservative Culture

(1993). THe Horror Film in Neoconservative Culture. Journal of Popular Film and Television: Vol. 21, Ethical Issues in Film and Television, pp. 100-110.
The vocational adaptation rating scales

The Vocational Adaptation Rating Scales (VARS) were developed to provide a comprehensive assessment of maladaptive social behavior related to vocational success, but not directly measuring job performance of mentally retarded workers. Psychometric information derived from the VARS is useful for developing individualized educational plans (IEPs) for compliance with Public Law 94-142; for program, worker or curriculum evaluations; and for predicting placement of workers in vocational training. Research indicates that VARS scores are internally consistent, moderately correlated with other vocational measures, unbiased with respect to sex and age differences, and independent of IQ. Inter-rater reliability is acceptable, and VARS profiles are accurate predictors of level of sheltered workshop placement of mentally retarded workers, independent of IQ, sex and age. Unlike other instruments, the VARS offers a profile of social behavior in a vocational context.
Sexual Dysfunction and the Patient with Burns

Sexual dysfunction in patients with burns has received only limited attention in the literature on burn care. We present five patients with burns whose sexual dysfunction responded to an eclectic treatment approach. A more extensive discussion on the relationship between post-traumatic stress disorder, other psychopathology, and sexual dysfunction in patients with burn injuries is presented. Neuroendocrinological, psychopathologic, psychodynamic, and physiological mechanisms that may be at play in patients with burns are proposed. The possible impact of post-traumatic stress disorder on sexuality is discussed. The illustrated cases suggest that sexual side effects of psychotropics, although fairly common, should not get in the way of proper use of antidepressants and antianxiety medications during the initial phase of treatment. Psychotropic and other commonly used medications in patients with burns, and the possible mechanisms of actions on sexuality, are reviewed.