cssi/SciSciGPT-SciSciNet huggingface dataset:
Discovery of a protein required for photosynthetic membrane assembly

About one-half of the ≈57 proteins of the photosynthetic membranes in plant chloroplasts is encoded in the chloroplast genome, translated on chloroplast ribosomes and cotranslationally inserted into the lipid bilayer of the thylakoids (flattened sacs; ref. 1). The other half is translated on cytosolic ribosomes from messenger RNA of nuclear genes and posttranslationally imported across the outer and inner chloroplast envelope membranes. The import machinery consists of smart receptor proteins, translocation channels, and chaperon proteins (2, 3). The photosynthetic proteins are assembled into five multisubunit complexes. There, the pigments for light harvesting and the electron transport molecules for the primary light-dependent charge separation and for the generation of protons and oxygen in the water-splitting reaction are positioned at the optimal distances. The two photosystems cooperate via the cytochrome b6f complex in the transfer of electrons to provide reducing power in the form of NADPH and establishment of proton gradients from the stroma side to the lumen of the thylakoid. The electrochemical gradient formed by the accumulation of protons in the thylakoid lumen provides the driving force for the phosphorylation of ADP by the ATP synthase complex. In contrast to the profound knowledge of the organization of the photosynthetic membrane and the import of the protein components into the chloroplast and their targeting to the thylakoids, progress in learning how the lipid bilayer membranes are formed is less obvious. This situation may change with the discovery of a function of the vesicle-inducing protein in plastids (VIPP) by Kroll et al. and Westphal et al. as reported in this issue of PNAS (4, 5).
Stereotactic Localization of Breast Lesions: How It Works and Methods to Improve Accuracy

A computer simulation of stereotactic breast biopsy was developed that paralleled the geometric configuration of a currently available breast biopsy system. This model was developed to define and improve the targeting of breast lesions with stereotactic biopsy techniques. Lesions must be clearly identified and accurately targeted on both views for successful localization. Nonvisualization of a lesion may result from overlying tissue or from the geometric configuration of the imaging system. Familiarity with the geometric configuration of the biopsy unit, especially the location of the reference point and center of rotation, facilitates understanding of apparent changes in lesion position (parallax shift). Inaccuracy in lesion targeting on one or both views will manifest predominantly as an error in the calculated z value (depth). The magnitude and direction of this error are largely determined by the direction of the targeting error. Compensatory strategies include use of a long-throw core biopsy gun or directional vacuum-assisted biopsy device and additional sampling along the z axis and should be accompanied by critical evaluation of both pre- and postfire images. Understanding geometric considerations as well as how targeting accuracy affects accuracy in lesion localization should lead to greater success in sampling even challenging breast lesions at stereotactic biopsy.
Chemisorptive enantioselectivity of chiral epoxides on tartaric-acid modified Pd(111): three-point bonding

The chemisorption of two chiral molecules, propylene oxide and glycidol, is studied on tartaric-acid modified Pd(111) surfaces by using temperature-programmed desorption to measure adsorbate coverage. It is found that R-glycidol shows preferential enantioselective chemisorption on (S,S)-tartaric acid modified Pd(111) surfaces, while propylene oxide does not adsorb enantioselectively. The enantioselectivity of glycidol depends on the tartaric acid coverage, and is exhibited for low tartaric acid coverages indicating that the bitartrate phase is responsible for the chiral recognition. The lack of enantioselectivity when using propylene oxide as a chiral probe implies that the enantiospecific interaction between glycidol and bitartate species is due to hydrogen-bonding interactions of the –OH group of glycidol. Scanning tunneling microscopy images were collected for tartaric acid adsorbed on Pd(111) under the same experimental conditions as used for enantioselective experiments. When tartaric acid is dosed at room temperature and immediately cooled to 100 K for imaging, individual bitartrate molecules were found. Density functional theory (DFT) calculations show that bitartrate binds to Pd(111) through its carboxylate groups and the –OH groups are oriented along the long axis of the bitartrate molecule. An enantiospecific interaction is found between glycidol and bitartate species where R-glycidol binds more strongly than S-glycidol to (S,S)-bitartate species by simultaneously forming hydrogen bonds with both the hydroxyl and carboxylate groups, thereby providing three-point bonding.
Viral exanthems: an update

Classic viral exanthems, such as measles, rubella, and Fifth disease, have great historical significance and, despite vaccine successes, still occur both in the United States and across the world. Because they are either less commonly seen (e.g., measles) or recognized by pediatricians (e.g., Fifth disease), viral exanthems that present to dermatology clinics are often "atypical" and may cause diagnostic confusion. This article will first review a general approach to the patient with a possible viral exanthem, discuss several current issues germane to "classic" exanthems, and delve into greater detail regarding atypical presentations.
Optimally weighted highpass filters using multiscale analysis

An obvious approach to image enhancement is to sharpen bright regions of an image more than darker regions. One very simple method to accomplish this is to weight the amount of highpass filtering proportional to the local mean. This gives rise to a class of nonlinear image enhancement filters known as mean-weighted highpass filters. We propose a general framework for studying a class of weighted highpass filters. Our framework, based on a multiscale signal decomposition, allows us to study a wide class of filters and to assess the merits of each. We derive an automatic procedure to optimally tune a filter to the local structure of the image under consideration. The entire algorithm is fully automatic and requires no parameter specification from the user. Several simulations demonstrate the efficacy of the proposed algorithm.
On the value of technological knowledge in semiconductor manufacturing

A model of the operating curve a semiconductor fabrication facility, which is sufficiently accurate to make capitalization decisions, has been developed. The model is used to simulate the performance of a hypothetical fab that operates under very realistic conditions. Results of the simulation show that the value of additional technological knowledge can be negative Learning more of a good thing is not always a good idea!
Kyphectomy in Children with Myelomeningocele

Background Patients with myelomeningocele and rigid lumbar and thoracolumbar kyphosis face substantial functional difficulties with sitting and lying supine and are prone to skin breakdown over the gibbus and risk of infection. Kyphectomy, along with cordotomy and segmental spinal instrumentation down to the pelvis, is one alternative that can provide reliable correction of the deformity but also can maintain that correction over a period of time.
Immobilization of Escherichia coli Cells Containing Aspartase Activity with Polyurethane and Its Application for l-Aspartic Acid Production.

Whole cells of Escherichia coli containing aspartase activity were immobilized by mixing a cell suspension with a liquid isocyanate-capped polyurethane prepolymer (Hypol). The immobilized cell preparation was used to convert ammonium fumarate to l-aspartic acid. Properties of the immobilized E. coli cells containing aspartase were investigated with a batch reactor. A 1.67-fold increase in the l-aspartic acid production rate was observed at 37°C as compared to 25°C operating temperature. The pH optimum was broad, ranging from 8.5 to 9.2. Increasing the concentration of ammonium fumarate to 1.5 M from 1.0 M negatively affected the reaction rate. l-Aspartic acid was produced at an average rate of 2.18 × 10−4 mol/min per g (wet weight) of immobilized E. coli cells with a 37°C substrate solution consisting of 1.0 M ammonium fumarate with 1 mM Mg2+ (pH 9.0).
Coherence in Dense Cores. II. The Transition to Coherence

After studying how line width depends on spatial scale in low-mass star-forming regions, we propose that dense cores (Myers & Benson 1983) represent an inner scale of a self-similar process that characterizes larger scale molecular clouds. In the process of coming to this conclusion, we define four distinct types of line width-size relation (ΔvRai), which have power-law slopes a1, a2, a3, and a4, as follows: Type 1—multitracer, multicloud intercomparison; Type 2—single-tracer, multicloud intercomparison; Type 3—multitracer study of a single cloud; and Type 4—single-tracer study of a single cloud. Type 1 studies (of which Larson 1981 is the seminal example) are compendia of Type 3 studies which illustrate the range of variation in the line width-size relation from one region to another. Using new measurements of the OH and C18O emission emanating from the environs of several of the dense cores studied in NH3 by Barranco & Goodman (1998; Paper I), we show that line width increases with size outside the cores with a4 ~ 0.2. On scales larger than those traced by C18O or OH,12CO and 13CO observations indicate that a4 increases to ~0.5 (Heyer & Schloerb 1997). By contrast, within the half-power contour of the NH3 emission from the cores, line width is virtually constant, with a4 ~ 0. We interpret the correlation between increasing density and decreasing Type 4 power-law slope as a transition to coherence. Our data indicate that the radius Rcoh at which the gas becomes coherent (i.e., a4 → 0) is of order 0.1 pc in regions forming primarily low-mass stars. The value of the nonthermal line width at which coherence is established is always less than but still of order of the thermal line width of H2. Thus coherent cores are similar to, but not exactly the same as, isothermal balls of gas. Two other results bolster our proposal that a transition to coherence takes place at ~0.1 pc. First, the OH, C18O, and NH3 maps show that the dependence of column density on size is much steeper (N R-0.9) inside Rcoh than outside of it (N R-0.2), which implies that the volume filling factor of coherent cores is much larger than in their surroundings. Second, Larson (1995) has recently found a break in the power law characterizing the clustering of stars in Taurus at 0.04 pc, just inside of Rcoh. Larson and we interpret this break in slope as the point at which stellar clustering properties change from being determined by the (fractal) gas distribution (on scales greater than 0.04 pc) to being determined by fragmentation processes within coherent cores (on scales less than 0.04 pc). We speculate that the transition to coherence takes place when a dissipation threshold for the MHD turbulence that characterizes the larger scale medium is crossed at the critical inner scale Rcoh. We suggest that the most likely explanation for this threshold is the marked decline in the coupling of the magnetic field to gas motions due to a decreased ion/neutral ratio in dense, high filling factor gas.
The sediment budget of an alpine cirque

Cirques form and evolve as glaciers attack the bed and subaerial processes dismantle the surrounding walls. Collectively, these processes—which can make a cirque longer, or deeper, or both—profoundly influence near-divide regions of glaciated mountains and yet are rarely studied in a systematic way. Toward this end, we developed a theoretical framework for the sediment budget of a cirque that includes sediment sources, transport pathways, and storage elements. We quantified each component of the sediment budget using field measurements and remote-sensing data of a glaciated alpine cirque in British Columbia, Canada. The cirque has a plan-view area of 1.64 km 2 and relief of ∼780 m. Our budget values, which correspond to a period of substantial glacier retreat, are based on measurements reflecting time intervals ranging from 1 yr to 80 yr. We report errors as a range (enclosed in parentheses), analogous to 95% confidence bounds. On average, 1640 (250–7950) metric tons of rock are released by the headwall each year; nearly 90% of this debris leaves the wall as small rockfalls or in snow avalanches. Our field observations indicated that snow avalanches originating as cornice failures are currently the most important transport process on the headwall. We estimated the mass of debris transported annually by the glacier to the foreland using (1) the volume and age of the foreland ground moraine and (2) the product of rock mass per unit volume of ice and glacier velocity. Over the past several decades, the glacier delivered 6440 (1180–14930) tons/yr to the foreland via forward ice motion and margin retreat (mostly in subglacial till or sediment-rich basal layers). Less than 3% of the glacierborne sediment flux traveled as supraglacial debris (170 [50–320] tons/yr). At present, sediment evacuation from the cirque occurs in a single meltwater stream. We monitored water discharge and suspended sediment concentration in this stream between 29 June and 28 August 2007. By season’s end, 650 (80–1860) tons of sediment had passed our gauging station (equivalent to an erosion rate of 0.2 [0.03–0.70] mm/yr, when averaged over the glacier bed). Approximately one third of the total annual streamborne sediment transport occurred over a 2 d period during the first major melt event of the year. Using our budget relations and flux magnitudes, we estimate the glacier is removing between 1240 and 2470 tons of rock from its bed per year, a rate equivalent to 0.5–0.9 mm/yr of erosion glacierwide. The headwall, by comparison, is being worn away horizontally at ∼1.2 (0.2–5.9) mm/yr. Thus, our results suggest that the headwall is retreating at rates roughly equivalent to vertical incision by the glacier. Our sediment budget results demonstrate that the wide variety of sediment sources and transport processes active in cirques necessitates a holistic view of cirque formation, one that most morphometric, range-scale, and glacial erosion analyses ignore.
Dynamic manipulation and separation of individual semiconducting and metallic nanowires

The synthesis of nanowires has advanced in the past decade to the point where a vast range of insulating, semiconducting and metallic materials1 are available for use in integrated, heterogeneous optoelectronic devices at nanometre scales2. However, a persistent challenge has been the development of a general strategy for the manipulation of individual nanowires with arbitrary composition. Here we report that individual semiconducting and metallic nanowires with diameters below 20 nm are addressable with forces generated by optoelectronic tweezers3. Using 100,000 times less optical power density than optical tweezers, optoelectronic tweezers are capable of transporting individual nanowires with speeds four times greater than the maximum speeds achieved by optical tweezers. A real-time array of silver nanowires is formed using photopatterned virtual electrodes, demonstrating the potential for massively parallel assemblies. Furthermore, optoelectronic tweezers enable the separation of semiconducting and metallic nanowires, suggesting a broad range of applications for the separation and heterogeneous integration of one-dimensional nanoscale materials.
A Conceptual Model and Implications for Coping with Stressful Events in Police Work

Experiencing acute stress is inherent in police work. The inability to cope effectively with stressful events can result in undesirable psychological and somatic outcomes, leading to chronic stress, burnout, and quitting the profession. Surprisingly, however, understanding the coping process in police stress and identifying effective coping strategies in response to stressful events has received only scant attention in the research literature. The purposes of this article are (a) to review the coping process in police stress, (b) to identify adaptive and maladaptive coping styles in police work, and (c) to suggest coping strategies that reflect the coping model to reduce both chronic and acute forms of stress and to improve job satisfaction and performance among police officers. The model consists of officers' detection of stressful events or stimuli, their cognitive appraisal of the events or stimuli, and their application of approach- or avoidance-coping dimensions, and cognitive- and behavioral-coping ...
NGOs in Kenya: Increase State Legitimacy or Undermine Popular Support?

According to theories of African politics, African states predicate their legitimacy on the promise of distributing services to the populace. This paper analyzes what happens when a new set of actors – non-governmental organizations (NGOs) – steps between state and society to deliver health care, education, water, etc. Does the introduction of largely foreign-funded organizations interrupt the flow of legitimacy from citizen to state? The literatures on NGOs and service provision in Africa suggest that this occurs: government legitimacy is undermined as NGOs call for democracy, accountability and rule of law, thereby developing active civil society in opposition to the state. And it happens as Africans compare responsive, generous, transparent and participatory NGOs to their less effective government.This paper analyzes the relationship between NGO provision of service and government legitimacy in Kenya. It examines whether the Kenyan government must provide services itself for legitimacy to accrue to it. When NGOs provide cheap services, distribute donor resources generously, and foster a democratic spirit of participation, is the result lower popular perceptions of government?There are four principle findings in this paper. First, most individuals have limited direct contact with NGOs. Second, at the same time, NGOs are generally regarded favorably – often better so than their government counterparts. Third, contact with and appreciation for NGOs does not translate into distaste for government. Finally, while NGOs appear not to have a major impact on legitimacy in general, there is some evidence of a significant difference in responses from urban versus rural dwellers, and on more versus less-educated individuals.
Identification of an EGFRvIII-JNK2-HGF/c-Met–Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion

Glioblastoma multiforme (GBM) is the most aggressive and common form of adult brain cancer. Current therapeutic strategies include surgical resection, followed by radiotherapy and chemotherapy. Despite such aggressive multimodal therapy, prognosis remains poor, with a median patient survival of 14 months. A proper understanding of the molecular drivers responsible for GBM progression are therefore necessary to instruct the development of novel targeted agents and enable the design of effective treatment strategies. Activation of the c-Jun N-terminal kinase isoform 2 (JNK2) is reported in primary brain cancers, where it associates with the histologic grade and amplification of the epidermal growth factor receptor (EGFR). In this manuscript, we demonstrate an important role for JNK2 in the tumor promoting an invasive capacity of EGFR variant III, a constitutively active mutant form of the receptor commonly found in GBM. Expression of EGFR variant III induces transactivation of JNK2 in GBM cells, which is required for a tumorigenic phenotype in vivo. Furthermore, JNK2 expression and activity is required to promote increased cellular invasion through stimulation of a hepatocyte growth factor–c-Met signaling circuit, whereby secretion of this extracellular ligand activates the receptor tyrosine kinase in both a cell autonomous and nonautonomous manner. Collectively, these findings demonstrate the cooperative and parallel activation of multiple RTKs in GBM and suggest that the development of selective JNK2 inhibitors could be therapeutically beneficial either as single agents or in combination with inhibitors of EGFR and/or c-Met.
A broad look at the literature on math word problem-solving interventions for third graders

AbstractThough research on effective instruction in math word problem solving is prominent at the middle and secondary levels, much less work has been done in elementary grades. In this article, we review the research on varied problem-solving instructional interventions at the third-grade level for students across ability levels. Third grade was chosen as the focus due to the fact that word problem-solving requirements are first introduced into the curriculum and standardized assessment at this point in time. Drawing on quantitative studies using single subject, quasi-experimental, and randomized controlled trial designs, we examine the instructional components and instructional content identified as effective across the 13 studies that met search criteria. Conclusions focus on current understanding of best practices, limitations of the existing research, and important considerations for future research.
Differences between IgA and IgE as secretory proteins

IgA is the prototype of a secretory immunoglobulin and usually is present in external fluids in proportions greater than in serum. Previous studies have suggested that IgE also is a secretory immunoglobulin. We measured IgE, IgA and albumin levels in nasal washings (NW), parotid fluids (PF) and serum in seventeen individuals. In secretions, all of these proteins were measured by radioimmunoassay (RIA). In serum, IgE was measured by RIA, IgA by a turbidimetric method, and albumin by radial immunodiffusion. IgA was detected in NW and PF in all individuals and IgA/total protein ratios in both of these secretions exceeded the corresponding ratios in serum (P less than 0-01). In contrast, IgE was detected only in NW from atopic subjects and IgE/total protein ratios were less than those in serum (P less than 0-02). IgE was not detected in the PF in any of the seventeen subjects. When the proportion (protein/total protein) of IgA, IgE, or albumin in NW was expressed as a percentage of the proportion in serum, IgA and IgE were increased when compared to albumin (P less than 0-01 and P less than 0-03, respectively). These results support the view that IgE is a secretory immunoglobulin in that it is present in NW in proportions greater than expected if it diffused from serum. However, IgE differs from secretory IgA in that ratios of IgE to total protein are greater in serum than in NW. This difference is discussed in terms of local production of IgE and passive diffusion into serum and nasal secretions. Finally, the observation that IgE is present in one external secretion while absent from another indicates that external secretions may be subdivided into two classes on the basis of their content of IgE.
Rapid-onset "need-free" sodium appetite after lesions of the dorsomedial medulla

Previous studies indicate the dorsomedial hindbrain is important in the maintenance of fluid balance. Lesions centering on the area postrema (AP) result in enhanced ad libitum intake of concentrated saline solutions on a 24-h basis as well as enhanced excretion of water and electrolytes. Additionally, rats with lesions of the AP are reported to have an exaggerated behavioral response to dipsogenic challenges that mimic depletion of the extracellular fluid compartment. In the studies reported here, we have observed that rats with lesions of the AP and immediately adjacent nucleus of the solitary tract consume large quantities of concentrated saline solutions within minutes of presentation. This intake does not appear to be related to sodium loss or depletion because the lesioned rats are in a positive sodium balance and the appetite persists after bilateral nephrectomy. These data, in conjunction with earlier studies, suggest that the dorsomedial medulla, including the AP, acts to prevent overconsumption of water and sodium that could result in increased extracellular fluid volume.
An Overview of the RF Government's Meetings

Among the issues and questions considered at the meetings of the Government of the Russian Federation in March 2015, there was a draft law envisaging the introduction of a simplified procedure for the submission of a voluntary declaration, by individuals, concerning their capital.
Microbial and Chemical Control of the Cabbage Looper on Fall Lettuce

Field tests on fall lettuce in southern Arizona during 1970–71 demonstrated the efficacy of a nuclear polyhedrosis Virus isolated from Autographa californica (ACNPV) for control of Trichoplusia ni (Hubner). An application rate of 7.4 × 1011 polyhedra/ha provided adequate control when compared to Bacillus thuringiensis Berliner or chemical insecticides. IMC Shade®, a protectant, did not enhance the effectiveness of the virus as a control agent. Combinations of the ACNPV with reduced application rates of chemical insecticides provided as good a control as chemicals alone. Cabbage looper damage to lettuce heads and weights at harvest was markedly reduced in virus and insecticide-treated plots.
Variabilities in the mortality-related resource utilisation for congenital heart disease.

Objective Our objective was to characterise the divergence of effort from outcome in congenital heart disease (CHD) care by measuring mortality-related resource utilisation fraction (MRRUF) for various CHD lesions across institutions of differing volumes. Methods Study design was observational analysis of an administrative database, the Pediatric Health Information System (PHIS). The setting was inpatient; 2004–2013. Patients were ≤21 years old with atrial septal defect (ASD), ventricular septal defect (VSD), tetralogy of Fallot (TOF), hypoplastic left heart syndrome (HLHS) or other single ventricle (SV). There were no interventions but diagnosis, institution (and volume), age, length of hospitalisation, billed charges and deaths were recorded. The main outcome measure was MRRUF, the ratio of investments during hospitalisations ending in fatality to investments during all hospitalisations. Results There were 50 939 admissions, 1711 deaths, 703 383 inpatient days, and $10 182 000 000 billed charges. MRRUF varied widely by diagnosis: highest in HLHS (21%), but present in ASD (2%) and VSD (4%). Highest among the very young, MRRUF also increased in HLHS and SV during adolescence. MRRUF increased with hospitalisation duration. MRRUF had no relation to institutional volume, and was static over the decade studied. Conclusions Even in the modern era we invest heavily in inpatient CHD care that does not produce the desired outcome. Although its magnitude varies by lesion and age, MRRUF is not limited to complex disease in the very young. MRRUF is not decreasing, and is not isolated to high or low volume institutions.
Evaluation of terrestrial photogrammetric point clouds derived from thermal imagery

Computer vision and photogrammetric techniques have been widely applied to digital imagery producing high density 3D point clouds. Using thermal imagery as input, the same techniques can be applied to infrared data to produce point clouds in 3D space, providing surface temperature information. The work presented here is an evaluation of the accuracy of 3D reconstruction of point clouds produced using thermal imagery. An urban scene was imaged over an area at the Naval Postgraduate School, Monterey, CA, viewing from above as with an airborne system. Terrestrial thermal and RGB imagery were collected from a rooftop overlooking the site using a FLIR SC8200 MWIR camera and a Canon T1i DSLR. In order to spatially align each dataset, ground control points were placed throughout the study area using Trimble R10 GNSS receivers operating in RTK mode. Each image dataset is processed to produce a dense point cloud for 3D evaluation.
Chronic hepatitis B infection in pregnancy

There are no standard guidelines to follow when a patient with chronic hepatitis B infection becomes pregnant or desires pregnancy. Topics to consider include which patients to treat, when to start treatment, what treatment to use and when to stop treatment. Without any prophylaxis or antiviral therapy, a hepatitis B surface antigen and E antigen positive mother has up to a 90% likelihood of vertical transmission of hepatitis B virus (HBV) to child. Standard of care in the United States to prevent perinatal transmission consists of administration of hepatitis B immune globulin and HBV vaccination to the infant. The two strongest risk factors of mother to child transmission (MTCT) of HBV infection despite immunoprophylaxis are high maternal HBV viral load and high activity of viral replication. The goal is to prevent transmission of HBV at birth by decreasing viral load and/or decreasing activity of the virus. Although it is still somewhat controversial, most evidence shows that starting antivirals in the third trimester is effective in decreasing MTCT without affecting fetal development. There is a growing body of literature supporting the safety and efficacy of antiviral therapies to reduce MTCT of hepatitis B. There are no formal recommendations regarding which agent to choose. Tenofovir, lamivudine and telbivudine have all been proven efficacious in decreasing viral load at birth without known birth defects, but final decision of which antiviral medication to use will have to be determined by physician and patient. The antivirals may be discontinued immediately if patient is breastfeeding, or within first four weeks if infant is being formula fed.
Photobiology in Medicine

I would like to spend a few minutes at the beginning of this symposium first, to put the involvement of photobiology in medicine in its historical context and secondly, to mention briefly some of the problems and advances in photomedicine that are active areas of research but which, because of exigencies of time could not be included in this symposium.
Pore Shrinkage and Ostwald Ripening

Two general approaches may be used in the theoretical description of the process of densification of a powder compact. One replaces the complex internal geometry of a compact by an idealized, well defined system of uniform pores and thus reduces the problem to one of shrinkage of a single pore in a specified geometrical environment. The second approach applies the methods of statistics to a model, geometrically resembling the structure of an actual compact.
Modeling Non-Equilibrium Turbulent Flows

Traditional turbulence models invoke a range of equilibrium assumptions that renders them incapable of describing turbulent flows where the departures from equilibrium are large. Even the commonly used second-order closures have an implicit equilibrium assumption for the pivotal pressure-strain correlation that makes them incapable of describing such non-equilibrium turbulent flows. It will be shown that explicit algebraic stress models can be partially extended to non-equilibrium turbulent flows by a Pade approximation. Then, by implementing a relaxation time approximation, second-order closures are obtained where — to the lowest order — the rapid pressure-strain correlation is represented by models that depend nonlinearly on the invariants of the non-dimensional strain rates. However, unlike in many of the more recent second-order closures, linearity is maintained in the Reynolds stress anisotropy tensor consistent with the definition of the rapid pressure-strain correlation. It will be demonstrated by a variety of examples how this leads to an improved performance in non-equilibrium turbulence without compromising the predictions for the near-equilibrium case. A new approach to large-eddy simulations will also be presented that allows subgrid scale stress models to continuously go to Reynolds stress models in the coarse mesh/infinite Reynolds number limit. Furthermore, the modeling of the turbulent dissipation rate will be considered, particularly in regard to the non-equilibrium effects of vortex stretching and anisotropic dissipation. The status of these recent developments and the prospects for future research will be thoroughly discussed.
Overcoming scaling barriers through design technology CoOptimization

Design technology co-optimization (DTCO) is the term used to describe the process of deriving a competitive technology definition out of a number of increasingly complex trade-offs. DTCO is not a specific approach or methodology, but rather a commitment to closer collaboration between designers and process engineers born out of necessity to maintain value in semiconductor scaling. This paper aims to clarify this abstract concept through a series of examples encountered in scaling a logic cell from the N14 to the N3 technology node.
Evidence handling in proactive cyberstalking investigations: the PAPA approach

Stalking is the malicious, unsolicited intrusion on another's personal space, and cyber-stalking extends this to cyberspace via Internet technology. All fifty U.S. states criminalized stalking in the 1990's, and many have passed cyberstalking statutes as well. The anonymity and reach of the Internet, and the difficulties in capturing, recording, and verifying digital evidence combine to create new challenges to law enforcement agencies trying to prevent and detect the crime and apprehend the criminals. In particular, the "expectation of privacy" afforded to all participants of live-wire communication makes it difficult to bind the actual perpetrator with his or her online persona. The PAPA system is a comprehensive toolkit that captures all relevant cyberstalking data with the potential for admissibility in a court of law. To this end, and as far as possible under existing federal, state, and international statutes, it captures data with the goal of producing evidence that is admissible, authoritative, reliable, complete, and believable.
Topical analysis of interactions between news and social media

The analysis of interactions between social media and traditional news streams is becoming increasingly relevant for a variety of applications, including: understanding the underlying factors that drive the evolution of data sources, tracking the triggers behind events, and discovering emerging trends. Researchers have explored such interactions by examining volume changes or information diffusions, however, most of them ignore the semantical and topical relationships between news and social media data. Our work is the first attempt to study how news influences social media, or inversely, based on topical knowledge. We propose a hierarchical Bayesian model that jointly models the news and social media topics and their interactions. We show that our proposed model can capture distinct topics for individual datasets as well as discover the topic influences among multiple datasets. By applying our model to large sets of news and tweets, we demonstrate its significant improvement over baseline methods and explore its power in the discovery of interesting patterns for real world cases.
Non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide cures the first adult patient with congenital dyserythropoietic anemia

Non-myeloablative allogeneic stem cell transplant with post-transplant cyclophosphamide cures the first adult patient with congenital dyserythropoietic anemia
Acculturative Stress and Adjustment Experiences of Greek International Students.

This study investigated eight Greek international college students’ experiences of acculturation and acculturative stress at a mid-western university in the United States. Semi-structured interviews were conducted with participants and Consensual Qualitative Research methodology was utilized for data analysis to identify contextual themes and domains expressed by participants. Seven domains relevant to extant literature were revealed: presojourn perceptions of the United States; postsojourn perceptions of the United States; acculturative stress problems in the United States; coping strategies for acculturative stress problems; peer and family networks: English language usage and difficulties; and cultural concerns regarding the United States or native country. Implications, areas for future research, and the study’s limitations are also discussed.
Prediction of Vancomycin Dose for Recommended Trough Concentrations in Pediatric Patients With Cystic Fibrosis

Vancomycin is a key antibiotic used in the treatment of multiple conditions including infections associated with cystic fibrosis and methicillin-resistant Staphylococcus aureus. The present study sought to develop a model based on empirical evidence of optimal vancomycin dose as judged by clinical observations that could accelerate the achievement of desired trough level in children with cystic fibrosis. Transformations of dose and trough were used to arrive at regression models with excellent fit for dose based on weight or age for a target trough. Results of this study indicate that the 2 proposed regression models are robust to changes in age or weight, suggesting that the daily dose on a per-kilogram basis is determined primarily by the desired trough level. The results show that to obtain a vancomycin trough level of 20 μg/mL, a dose of 80 mg/kg/day is needed. This analysis should improve the efficiency of vancomycin usage by reducing the number of titration steps, resulting in improved patient outcome and experience.
Photodynamic therapy: the role of paraptosis

Apoptosis is a pathway to cell death frequently observed after photodynamic therapy (PDT). Sub-cellular photodamage to mitochondria, lysosomes, the ER, or combinations of these targets, can lead to apoptotic death. We have recently investigated another pathway to cell death after PDT termed ‘paraptosis’. This is characterized by extensive cytoplasmic vacuolization, does not involve caspase activation or nuclear fragmentation, requires a brief interval of continued protein synthesis and appears to derive from ER stress. Determinants and further characteristics of PDT-derived paraptosis are explored in the A549 non small-cell lung cancer cell line and in cells derived from head and neck cancer tissues. We provide evidence that ER photodamage and JNK pathway activation are involved in PDT-mediated paraptosis.
A Parallel Ocean Model With Adaptive Mesh Refinement Capability For Global Ocean Prediction

An ocean model with adaptive mesh refinement (AMR) capability is presented for simulating ocean circulation on decade time scales. The model closely resembles the LLNL ocean general circulation model with some components incorporated from other well known ocean models when appropriate. Spatial components are discretized using finite differences on a staggered grid where tracer and pressure variables are defined at cell centers and velocities at cell vertices (B-grid). Horizontal motion is modeled explicitly with leapfrog and Euler forward-backward time integration, and vertical motion is modeled semi-implicitly. New AMR strategies are presented for horizontal refinement on a B-grid, leapfrog time integration, and time integration of coupled systems with unequal time steps. These AMR capabilities are added to the LLNL software package SAMRAI (Structured Adaptive Mesh Refinement Application Infrastructure) and validated with standard benchmark tests. The ocean model is built on top of the amended SAMRAI library. The resulting model has the capability to dynamically increase resolution in localized areas of the domain. Limited basin tests are conducted using various refinement criteria and produce convergence trends in the model solution as refinement is increased. Carbon sequestration simulations are performed on decade time scales in domains the size of the North Atlantic andmore » the global ocean. A suggestion is given for refinement criteria in such simulations. AMR predicts maximum pH changes and increases in CO{sub 2} concentration near the injection sites that are virtually unattainable with a uniform high resolution due to extremely long run times. Fine scale details near the injection sites are achieved by AMR with shorter run times than the finest uniform resolution tested despite the need for enhanced parallel performance. The North Atlantic simulations show a reduction in passive tracer errors when AMR is applied instead of a uniform coarse resolution. No dramatic or persistent signs of error growth in the passive tracer outgassing or the ocean circulation are observed to result from AMR.« less
Mapping tool for maintaining vocabulary relationships.

The Informatics for Integrating Biology and the Bedside (i2b2) is one of the sponsored initiatives of the NIH Roadmap National Centers for Biomedical Computing (http://www.bisti.nih.gov/ncbc/). One of the goals of i2b2 is to provide clinical investigators broadly with the software tools necessary to collect and manage project-related clinical research data in the genomics age as a cohesive entity – a software suite to construct and manage the modern clinical research chart. Maintaining relationships between terms in multiple vocabularies is a vital activity for any organization attempting to support the integration of data coming from multiple sources. In a clinical research setting, in fact, this activity becomes even more significant. Combined laboratory and clinical data from diverse systems, with semantically related codes, terms and concepts, can help transform genomic knowledge into the practice of healthcare. Unless these vocabulary relationships are defined, however, the potential for considerable insight is lost. Maintaining these relationships, then, becomes a priority. Vocabulary mapping is a process of specifying and maintaining relationships between terms in multiple vocabularies. One vocabulary, designated as master becomes the classification scheme for the other subsidiary vocabularies.1 In order to use a system like this, there must be some way of maintaining freedom and control over the master vocabulary, while still maintaining the integrity of the mappings to each source. Though, there is no single tool to accomplish all of this, some existing tools offer a great deal of functionality, especially in the area of maintaining a single vocabulary. One tool, Protege, is particularly well suited to maintaining concepts and relationships within a vocabulary.2 Its support for the creation and maintenance of ontologies, including taxonomies, classifications and their associated vocabulary make it an ideal tool for managing a distinct vocabulary. The master vocabulary, in turn, provides the base hierarchy upon which to map other vocabulary sources. The problem, then, reduces to managing mappings to outside source vocabularies, which itself, is not a small task. A new mapping tool shown above will integrate with Protege and facilitate mappings between the base hierarchy and source terms. This tool allows a user to efficiently locate source and base concepts and create multiple mappings, reducing the time and cost of maintaining vocabulary relationships while enforcing the correct management of an Ontology through Protege. By leveraging the strengths of Protege and addressing the mapping problem with a new tool within the i2b2 framework, we can create a powerful solution that will make possible the goal of integrating biology and the bedside.
A randomized usability assessment of simulated naloxone administration by community members.

BACKGROUND AND AIMS Expanded access to naloxone has been identified as a key intervention for reducing opioid-related morbidity and mortality. It is not known which naloxone device will result in rapid, successful administration when administered by community members. The aims of this study were to estimate and compare (1) the rate of successful administration and (2) time to successful administration for single-step nasal spray, multi-step atomized nasal spray and intramuscular simulated naloxone by community members. DESIGN A prospective, single-site, open-label, randomized usability assessment of simulated naloxone administration in a convenience sample of community members. Participants were randomized to single-step nasal spray (SP), multi-step atomized nasal spray (AT) or intramuscular simulated (IM) naloxone and asked to administer the simulated medication to a mannequin after completing a 2-minute training video. SETTING New York, USA at a state fair that attracts between 60 000 and 120 000 individuals daily. PARTICIPANTS A total of 138 participants completed the study over a 2-day period in September 2016. All participants were at least 18 years of age and had no prior naloxone training. MEASUREMENTS The rate of successful administration and time to successful administration were recorded for each device. FINDINGS The SP device (100%; P < 0.001) had a higher rate of success compared with the IM device (69.6%). Although success differed between the AT (89.1%) device and IM device, as well as the AT device and SP device, these differences were not significant. The SP device also had a shorter median time to successful administration (34.3 sec) compared with the IM (99.9 sec; P < 0.001) and AT (110.3; P < 0.001) devices. CONCLUSIONS After video training, community members are able to (1) administer single-step nasal spray naloxone with a higher rate of success than intramuscular naloxone in a simulated overdose setting and (2) administer single-step nasal spray naloxone more rapidly than both intramuscular and multi-step atomized nasal spray naloxone.
The Role of Latinx Fathers in Their Daughters' College Success: Shifting Cultural Paradigms?.

The focus of this article is the result of an unexpected finding in a life narrative qualitative study. The research was conducted in a predominately White, research-extensive Midwestern state univ...
Fully realizing partial realization

There has been a movement in philosophy, growing over the last twenty years, to treat dispositionality as irreducible and, in turn, offer dispositional accounts of important metaphysical matters such as the laws of nature, free will, causation, and modality. However, unlike the earlier turn towards possible worlds in metaphysics, the turn towards dispositions hasn’t had much impact in semantics. But this is, in my view, largely because semanticists have yet to consider what dispositional analyses of (say) tense, aspect, generics, or modals would look like. My aim in this paper is to push the dispositionality movement forward on the semantics front by considering a dispositional analysis of the progressive aspect.
Association Between Rotator Cuff Muscle Size and Glenoid Deformity in Primary Glenohumeral Osteoarthritis.

Background:Although glenoid morphology has been associated with fatty infiltration of the rotator cuff in arthritic shoulders, the association of rotator cuff muscle area with specific patterns of glenoid wear has not been studied. The purpose of our study was to assess the associations of glenoid d