cssi/SciSciGPT-SciSciNet huggingface dataset:
A visuospatial variant of mild cognitive impairment: Getting lost between aging and AD

Background: AD causes visuospatial disorientation that is associated with posterior cortical atrophy and impaired visual motion processing. Objective: The authors characterized memory capacity and visual motion processing in young normal (YN) and older normal (ON) adult subjects and in patients with mild cognitive impairment (MCI) and AD to see if deficits in these realms occur as isolated impairments. Methods: Each participant underwent neuropsychological testing and gave push-button responses to indicate perception of panoramic visual motion stimuli. Results: One fifth of the ON subjects, one third of the patients with MCI, and half of the patients with AD showed increasingly pervasive impairments of visual motion perception. These impairments were associated with poorer performance on the Money Road Map test of spatial navigation but not with verbal or visual memory deficits. Conclusion: Impaired visual motion processing may accompany memory deficits in MCI or AD, or may occur alone in otherwise intact ON subjects. This suggests that visuospatial impairment may develop as an independent sign of neurodegenerative disease, possibly preceding the clinical onset of AD.
Control of Atm-/- thymic lymphoma cell proliferation in vitro and in vivo by dexamethasone

Aim Ataxia telangiectasia (A-T) is an autosomal recessive disease in humans caused by mutations in the Atm (A-T mutated) gene. The disease involves multiple organ systems, and is associated with a high incidence of leukemias and lymphomas that develop in childhood. We have reported previously that thymic lymphoma development in Atm knockout (Atm−/−) mice is associated with elevated spontaneous DNA synthesis in thymocytes, and that dexamethasone (Dex) attenuates the elevated DNA synthesis and prevents thymic lymphoma development. The primary objectives of the present study were (1) to investigate possible mechanisms underlying the tumor-suppressing effect of Dex on Atm−/− thymic lymphoma cells, and (2) to determine whether Dex is an effective tumor-suppressing treatment in mice bearing transplanted Atm−/− thymic tumors.
Cumulative childhood stress and autoimmune diseases in adults.

Objective: To examine whether childhood traumatic stress increased the risk of developing autoimmune diseases as an adult. Methods: Retrospective cohort study of 15,357 adult health maintenance organization members enrolled in the Adverse Childhood Experiences (ACEs) Study from 1995 to 1997 in San Diego, California, and eligible for follow-up through 2005. ACEs included childhood physical, emotional, or sexual abuse; witnessing domestic violence; growing up with household substance abuse, mental illness, parental divorce, and/or an incarcerated household member. The total number of ACEs (ACE Score range = 0-8) was used as a measure of cumulative childhood stress. The outcome was hospitalizations for any of 21 selected autoimmune diseases and 4 immunopathology groupings: T- helper 1 (Th1) (e.g., idiopathic myocarditis); T-helper 2 (Th2) (e.g., myasthenia gravis); Th2 rheumatic (e.g., rheumatoid arthritis); and mixed Th1/Th2 (e.g., autoimmune hemolytic anemia). Results: Sixty-four percent reported at least one ACE. The event rate (per 10,000 person-years) for a first hospitalization with any autoimmune disease was 31.4 in women and 34.4 in men. First hospitalizations for any autoimmune disease increased with increasing number of ACEs (p /=2 ACEs were at a 70% increased risk for hospitalizations with Th1, 80% increased risk for Th2, and 100% increased risk for rheumatic diseases (p Language: en
Inaccessibility of the Euplotes telomere binding protein.

The telomere binding protein (TP) from the macronucleus of the ciliateEuplotes eurystomus was purified by removal of tenaciously bound DNA with hydroxylapatite, and the purified TP partially sequences. Rabbit antiserum was generated against a synthetic peptide of 14 amino acids at the amino-terminus of the TP. This antiserum was employed to examine the accessibility of TP antigenic determinants in nuclei and chromatin. Immunofluorescent staining of isolated macronuclei revealed only weak reactivity with specific antiserum. Reactivity within replication bands was demonstrated, and could be augumented by preparation of nuclear scaffolds. Employing a dot immunoblot analysis, the amino-terminal antigenic determinants of TP were revealed after extraction of histone H1 (and some nonhistones). A different aspect of TP inaccessibility was demonstrated by immunoblot analysis of trypsin-treated macronuclei and chromatin; TP was considerably less susceptible to digestion by trypsin than were histones H1 and H3. The relative inaccessibility of TP was not a consequence of chromatin higher-order structure, since soluble macronuclear chromatin in low salt exhibited the same burying of antigenic determinants by dot blot analysis, and the same decreased susceptibility to trypsin, as did isolated nuclei. Electron microscopy of soluble macronuclear chromatin spread in low salt revealed that most telomeres appear unfolded, without stable higher-order structure. The mechanisms for the relative inaccessibility of TP are not yet known, but probably arise as a consequence of the strong interactions of TP with the telomere nucleotide sequence and additional interactions of TP with various chromatin proteins, perhaps including histone H1.
Degradation of 4‐chlorophenol in denitrifying fluidized‐bed process

Abstract Chlorophenol degradation by dissimilatory nitrate reduction was studied in an anoxic fluidized‐bed reactor. 4‐Chlorophenol (4‐CP) served as a carbon source for denitrification although both 4‐CP and nitrate removals remained incomplete (23–82 and 9–60%, respectively) at 5 h hydraulic retention time. Under varying experimental conditions, 1.9–2.5 mg 4‐CP was degraded and dechlorinated per 1 mg NO3‐N reduced. This is higher than the theoretical 4‐CP/NO3‐N ratio of 1.8 and the difference is likely due to aerobic degradation in the presence of trace concentrations of oxygen. The mass balance based on inorganic chloride release and disappearance of the parent compound gave further evidence of chlorophenol degradation in the system.
Flight Habits of the Maize Weevil, Sitophilus zeamais

A 3-year study of the dispersal of the maize weevil, Sitophilus zemais Motschulsky, from a corn storage bin was made at Baton Rouge. Dispersal was determined by the use of sticky traps. Beginning in January and continuing through December adult weevil emergence occurred on days when the temperature reached 23.3°C. Weevil dispersal reached a peak about July 7 (average of 3 years) after which it declined. Dispersal practically ceased hy the end of the year. Greatest emergence occurred during the warmer months. Dates of peak emergence, however, differed for each of the 3 years. The sex ratio of the trapped weevils was approximately 1: 1. Almost 100% of the females leaving the bin had been mated. Time of greatest dispersal flight occurred between 4 and 6PM. This period followed the warmest part of the day. More maize weevils were found to enter a field of corn at average plant ear height than at a level between 1 and 2 feet elevation.
Comment on ‘‘testing’’ the Gamow-Teller sum rule

Several recent papers purport to ``test'' the Gamow-Teller sum rule. They compare the differences between incomplete strength function integrals for the ${\mathrm{\ensuremath{\beta}}}^{\mathrm{\ensuremath{-}}}$ and ${\mathrm{\ensuremath{\beta}}}^{+}$ directions with the quantity 3(N-Z) and interpret discrepancies as degrees of failure of the sum rule. We point out that the Gamow-Teller sum rule is an exact operator relationship, not a model to be tested. It is useful for determining whether a measured strength function is complete.
Culturally competent care: emphasis on understanding the people of Afghanistan, Afghanistan Americans, and Islamic culture and religion

Since the attacks in New York and Washington, DC, in September 2001, increased racial and religious animosity has left Arabs, other Middle Easterners, Muslims, and those who bear physical resemblance to members of these groups, fearful. This article provides information about the people of Afghanistan, Afghanistan Americans, and Islamic culture and religion, which can greatly assist the nurse who is confronted with persons from diverse cultures during the provision of care. The Giger & Davidhizar Transcultural Assessment Model was first published in the International Nursing Review in 1990. This model is now used worldwide and provides an assessment model to assist in understanding cultural phenomena and individuals from different cultures.
Central European summer temperature variability to increase

More extreme heat waves have been observed in central Europe in recent years as summer temperature variability has increased on both daily and interannual timescales. Models project that as the climate warms throughout the 21st century, this increased variability will continue.
Confronting the brain in the classroom Lycée policy and pedagogy in France, 1874–1902

During the influx of neurological research into France from across Europe that took place rapidly in the late 19th century, the philosophy course in lycees (the French equivalent of high schools) was mobilized by education reformers as a means of promulgating the emergent brain sciences and simultaneously steering their cultural resonance. I contend that these linked prongs of philosophy’s public mission under the Third Republic reconciled contradictory pressures to advance the nation’s scientific prowess following its defeat in the Franco-Prussian war of 1870 without dropping France’s distinct tradition of 19th-century spiritualism, which extended from Maine de Biran’s philosophical psychology to Victor Cousin’s official eclectic spiritualism. Between 1874 and 1902, the French Ministry of Public Instruction transformed philosophy into a national project designed to guide the reception of experimental psychology generally and neurology in particular. This article features original archival research on phi...
Lepidopteran peritrophic membranes and effects of dietary wheat germ agglutinin on their formation and structure

Peritrophic membrane (PM) structure and the effects of dietary wheat germ agglutinin (WGA) on PM formation were studied in larvae of the European corn borer (ECB), Ostrinia nubilalis, and the tobacco hornworm (THW), Manduca sexta. Growth of ECB was strongly inhibited by low amounts of WGA in the diet (0.05%), whereas THW was not affected by amounts of up to 2%. In ECB larvae, chitin microfibrils were secreted to form an orthogonal network within the apical region of the anterior midgut microvilli. The network then moved to the tips of the microvilli where proteinacious matrix was added prior to delamination of a single PM into the lumen to enclose the food bolus. Multiple PMs rapidly appeared as the food moved posteriorly and some of these became greatly thickened in the middle and posterior regions of the midgut. WGA in the diet caused hypersecretion of unorganized PM in the anterior midgut lumen, disintegration of microvilli, and cessation of feeding. It was also shown to bind to both the chitinous network and to several PM proteins, perhaps causing voids in the PM and sparse matrix material. This allowed the passage of food particles through a defective PM into the ectoperitrophic space and penetration into the microvillar brush border. Stimulation of PM secretion and cessation of feeding may have been a response to damage to the brush border. Unlike ECB, the chitinous network of THW is a randomly organized felt-like structure embedded in a proteinaceous matrix. This PM is secreted as a thin multilayered structure in the anterior region of the midgut, but multiple and thickened PMs occur in the middle and posterior lumens of the midgut. THW tolerated high amounts of WGA in its diet with no disruption of PM formation or inhibition of growth. WGA did accumulate as large masses embedded in the PM, but caused no voids that would allow the penetration of food particles and subsequent damage to the brush border. Therefore, differences in PM formation and structure between ECB and THW appeared to affect how WGA interacts with chitinous and proteinaceous components of the PM and subsequent effects on larval feeding and growth.
Nonlinear transform coding: polar coordinates revisited

Summary form only given. We designed a family of integer-to-integer (i2i) approximations to the Cartesian-to-polar transformation and analyzed its behavior for high-rate transform coding. Denoting (ordinary, continuous) polar coordinates by (r, 0), our precise high-rate analysis relates the performance to the differential entropies of r/sup 2/ and 0, which are often easy to evaluate. One may thus predict when there is an improvement over linear transform coding. The analysis matches our simulations for coding of Gaussian scale mixtures and other polar-separable sources. The advantage over the best linear transform coder can be large. Our hope is to extend the polar-coordinate results to a general theory for nonlinear transform coding based on i2i implementations of arbitrary nonlinear transformations.
p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.

We have previously reported that when DNA replication is blocked in some human cell lines, p53 is impaired in its ability to induce a subset of its key target genes, including p21WAF1/CIP1. Here, we investigated the reason for this impairment by comparing the effects of two agents, hydroxyurea (HU), which arrests cells in early S phase and impairs induction of p21, and daunorubicin, which causes a G2 block and leads to robust activation of p21 by p53. HU treatment was shown to inhibit p21 mRNA transcription rather than alter its mRNA stability. Nevertheless, chromatin immunoprecipitation assays revealed that HU impacts neither p53 binding nor acetylation of histones H3 and H4 within the p21 promoter. Furthermore, recruitment of the TFIID/TATA-binding protein complex and the large subunit of RNA polymerase II (RNA Pol II) are equivalent after HU and daunorubicin treatments. Relative to daunorubicin treatment, however, transcription elongation of the p21 gene is significantly impaired in cells treated with HU, as evidenced by reduced occupancy of RNA Pol II at regions downstream of the start site. Likewise, in the p21 downstream region after administration of HU, there is less of a specifically phosphorylated form of RNA Pol II (Pol II-C-terminal domain serine 2P) which occurs only when the polymerase is elongating RNA. We propose that while the DNA replication checkpoint is unlikely to regulate the assembly of a p21 promoter initiation complex, it signals to one or more factors involved in the process of transcriptional elongation.
The genetics of Charcot-Marie-Tooth disease: current trends and future implications for diagnosis and management

Charcot-Marie-Tooth (CMT) disease is the most common hereditary polyneuropathy and is classically associated with an insidious onset of distal predominant motor and sensory loss, muscle wasting, and pes cavus. Other forms of hereditary neuropathy, including sensory predominant or motor predominant forms, are sometimes included in the general classification of CMT, but for the purpose of this review, we will focus primarily on the forms associated with both sensory and motor deficits. CMT has a great deal of genetic heterogeneity, leading to diagnostic considerations that are still rapidly evolving for this disorder. Clinical features, inheritance pattern, gene mutation frequencies, and electrodiagnostic features all are helpful in formulating targeted testing algorithms in practical clinical settings, but these still have shortcomings. Next-generation sequencing (NGS), combined with multigene testing panels, is increasing the sensitivity and efficiency of genetic testing and is quickly overtaking targeted testing strategies. Currently, multigene panel testing and NGS can be considered first-line in many circumstances, although obtaining initial targeted testing for the PMP22 duplication in CMT patients with demyelinating conduction velocities is still a reasonable strategy. As technology improves and cost continues to fall, targeted testing will be completely replaced by multigene NGS panels that can detect the full spectrum of CMT mutations. Nevertheless, clinical acumen is still necessary given the variants of uncertain significance encountered with NGS. Despite the current limitations, the genetic diagnosis of CMT is critical for accurate prognostication, genetic counseling, and in the future, specific targeted therapies. Although whole exome and whole genome sequencing strategies have the power to further elucidate the genetics of CMT, continued technological advances are needed.
Ideal spiral bevel gears - A new approach to surface geometry

This paper discusses the fundamental geometrical characteristics of spiral bevel gear tooth surfaces. The parametric representation of an ideal spiral bevel tooth is developed. The development is based on the elements of involute geometry, differential geometry, and fundamental gearing kinematics. A foundation is provided for the study of nonideal gears and the effects of deviations from ideal geometry on the contact stresses, lubrication, wear, fatigue life, and gearing kinematics.
THE ROLE OF INTERLEUKIN-1β IN THE PATHOGENESIS OF MULTIPLE MYELOMA

Interleukin-1 beta has potent OAF activity, can increase the expression of adhesion molecules, and can induce paracrine IL-6 production (see Fig. 1). These biologic effects of IL-1 beta closely parallel several of the clinical features of human myeloma, such as osteolytic bone lesions, homing of myeloma cells to the bone marrow, and IL-6-induced cell growth. The increased production of adhesion molecules could explain why myeloma cells are found predominantly in the bone marrow. These fixed monoclonal plasma cells could subsequently stimulate osteoclasts through the production of IL-1 beta and paracrine generation of IL-6, resulting in osteolytic disease. Also, IL-6 produced by either a paracrine or autocrine mechanism can support the growth of the myeloma cells that may be manifested clinically by an elevated labeling index. In the future, continued follow-up of IL-1 beta-positive and IL-1 beta-negative MGUS patients should determine whether aberrant expression of IL-1 beta by monoclonal plasma cells is a critical genetic event in the progression of MGUS to myeloma. Because MGUS is relatively common in the general population and myeloma is incurable in almost all cases, identification of MGUS patients who are likely to progress to active myeloma will be important in the development of new therapeutic strategies. For example, an effective chemopreventive agent that prevents or delays the transition from MGUS to myeloma could have a major effect on the treatment of patients with monoclonal gammopathies.
Low-Temperature Reflow Anneals of Cu on Ru

Low-temperature reflow anneals of physical-vapor-deposited (PVD) Cu on Ru are achieved at a Cu/low-k integration-compatible low temperature of 250°C by surface diffusion. Feature-fill capability is also demonstrated in patterned features along with reasonable electrical measurements. As compared to typical impurity levels in the conventional electroplated Cu, the reflowed PVD Cu had higher purity, which then resulted in lower electrical resistance in the structures. Electromigration test results further confirmed the reliability of the reflowed-Cu/Ru interface.
Portfolio selection with transaction costs

The author studies a stochastic optimization problem modeling the consumption and investment problem of a single agent. The model contains linear transaction costs and has been already studied by M.H.A. Davis and A.R. Norman (1990). In this paper, the author carries out the analysis under minimal assumptions and also for the deterministic case. >
Wavelet Analysis of Wall-Pressure Fluctuations in a Supersonic Blunt-Fin Flow

Measurements of wall-pressureuctuations in a Mach 3 ¯ ow over a blunt ® n wereanalyzed with the continuous wavelet transform. This technique offers a fresh approach to the problem of inferringow structure from the wall-pressure signal. The time scales associated with large-scale structures in theow turbulence and with shock crossing events are identi® ed as distinct local maxima in the distribution of energy over the wavelet scales. By using the extrema in the wavelet spectrum as a reference, the signal can be ® ltered in the space of wavelet scales to separate the contribution to the pressureuctuations ofow turbulence and separation shock motion.
Use of Transmitochondrial Cybrids To Assign a Complex I Defect to the Mitochondrial DNA-Encoded NADH Dehydrogenase Subunit 6 Gene Mutation at Nucleotide Pair 14459 That Causes Leber Hereditary Optic Neuropathy and Dystonia

A heteroplasmic G-to-A transition at nucleotide pair (np) 14459 within the mitochondrial DNA (mtDNA)-encoded NADH dehydrogenase subunit 6 (ND6) gene has been identified as the cause of Leber hereditary optic neuropathy (LHON) and/or pediatric-onset dystonia in three unrelated families. This ND6 np 14459 mutation changes a moderately conserved alanine to a valine at amino acid position 72 of the ND6 protein. Enzymologic analysis of mitochondrial NADH dehydrogenase (complex I) with submitochondrial particles isolated from Epstein-Barr virus-transformed lymphoblasts revealed a 60% reduction (P < 0.005) of complex I-specific activity in patient cell lines compared with controls, with no differences in enzymatic activity for complexes II plus III, III and IV. This biochemical defect was assigned to the ND6 np 14459 mutation by using transmitochondrial cybrids in which patient Epstein-Barr virus-transformed lymphoblast cell lines were enucleated and the cytoplasts were fused to a mtDNA-deficient (p 0) lymphoblastoid recipient cell line. Cybrids harboring the np 14459 mutation exhibited a 39% reduction (p < 0.02) in complex I-specific activity relative to wild-type cybrid lines but normal activity for the other complexes. Kinetic analysis of the np 14459 mutant complex I revealed that the Vmax of the enzyme was reduced while the Km remained the same as that of wild type. Furthermore, specific activity was inhibited by increasing concentrations of the reduced coenzyme Q analog decylubiquinol. These observations suggest that the np 14459 mutation may alter the coenzyme Q-binding site of complex I.
REACTION OF GENOTYPES OF CITRUS SPECIES AND VARIETIES TO XANTHOMONAS CITRI subsp CITRI UNDER GREENHOUSE CONDITIONS

Resistance of citrus genotypes to Asian citrus canker, caused by Xanthomonas citri subsp. citri (Xcc) was evaluated on 582 accessions (319 varieties of sweet orange), including varieties with a potential commercial use. All accessions were grown in a greenhouse and were sprayinoculated with Xcc to screen for resistance, based on analyses of lesion expansion. Inoculum (108 CFU/ml) was applied on the abaxial side of all leaves and all plants were incubated up to 30 days. Area of lesions on inoculated leaf blades was scanned and compared with healthy foliar area. A disease index was obtained and used to classify response to citrus canker. Two experiments were carried out with different varieties and distinct periods. A wide range of reaction was observed, with approximately 13% of all accessions resistant to citrus canker, 42% moderately resistant, 20% susceptible, and 25% highly susceptible.
Electromagnetic scattering model for a tree trunk above a tilted ground plane

An efficient and realistic electromagnetic scattering model for a tree trunk above a ground plane is presented. The trunk is modeled as a finite-length stratified dielectric cylinder with a corrugated bark layer. The ground is considered to be a smooth homogeneous dielectric with an arbitrary slope. The bistatic scattering response of the cylinder is obtained by invoking two approximations. In the microwave region, the height of the tree trunks are usually much larger than the wavelength. Therefore the interior fields in a finite length cylinder representing a tree trunk can be approximated with those of an infinite cylinder with the same physical and electrical radial characteristics. Also an approximate image theory is used to account for the presence of the dielectric ground plane which simply introduces an image excitation wave and an image scattered field. An asymptotic solution based on the physical optics approximation is derived which provides a fast algorithm with excellent accuracy when the radii of the tree trunks are large compared to the wavelength. The effect of a bark layer is also taken into account by simply replacing the bark layer with an anisotropic layer. It is shown that the corrugated layer acts as an impedance transformer which may significantly decrease the backscattering radar cross section depending on the corrugation parameters. It is also shown that for a tilted ground plane a significant cross-polarized backscattered signal is generated while the co-polarized backscattered signal is reduced. >
Trans-indigenous: Methodologies for global native literary studies [Book Review]

Review(s) of: Trans-indigenous: Methodologies for global native literary studies, by Allen, Chadwick, (2012), Minneapolis, MN, University of Minnesota Press, 301 pp., ISBN, 9780816678198.
Acceleration induced shear strains in a monkey brain hemisection

A freshly dead Stumptail monkey brain hemisection model has been subjected to translation, pure rotation and a combination motion. Linear and angular head accelerations were measured as well as brain displacement relative to the skull and shear strain at several locations. Much higher than previously predicted shear strain was measured at acceleration levels which have been recorded during impacts which produced concussion in live monkeys. Pure rotation produced the highest, most in live monkeys. Pure rotation produced the highest, most diffuse and long lasting shear strain and brain displacement, while translation produced very low shear strain. Highest strain during rotation was recorded in the brainstem. Results suggest that the mechanism of brainstem injury is due to shear caused by stretching of the cervical cord.
Old (Chicago) school, new century: the link between Knight and Simons’ Chicago plan to Buchanan’s constitutional money

James Buchanan had long been a champion of the early Chicago school’s emphasis on the essential role that institutions play in framing the market process. In his post-2009 analysis of the financial crisis, Buchanan echoed his old Chicago mentors like Frank Knight and Henry Simons in arguing that the Great Recession, like all previous financial crises, was primarily a failure of the rules governing our monetary-financial system. This “old Chicago” emphasis on the institutional “rules of the game” formed the basis of his essential post-2009 argument that the financial crisis fundamentally represented not a market failure, per say, but a constitutional failure. In this paper, I connect the dots in Buchanan’s post-2009 analysis of the Great Recession and his reaffirmation of the need for “constitutional money” to his old Chicago mentor’s strikingly similar calls for a radical restructuring of the monetary-financial system in the Chicago Plan of the 1930s. Though Buchanan’s twenty-first century resurrection of these ideas has yet to conjure up the academic support of his predecessors, certain elements of his “old school” monetary-financial reforms have experienced a strong revival since the financial crisis, as has Buchanan’s more general call to “constitutionalize money.”
The Global Burden of Fungal Diseases

Fungal diseases require greater attention today than ever before, given the expanding population of immunosuppressed patients who are at higher risk for these diseases. This article reports on distribution, incidence, and prevalence of various fungal diseases and points out gaps in knowledge where such data are not available. Fungal diseases that contribute substantially to global morbidity and mortality are highlighted. Long-term, sustainable surveillance programs for fungal diseases and better noninvasive and reliable diagnostic tools are needed to estimate the burden of these diseases more accurately.
Effect of Occupation-Based Groups on Self-Concept of Children Aged 5–8: A Pilot Study

The goal of this pilot study was to ascertain the effectiveness of an occupation-based after-school program for improving self-concept in children, ages five through eight. Fifty-four randomly selected children ages five through eight from two schools (one being the control group) with similar socioeconomic status along the Ohio River were involved in this research study. The Pictorial Scale of Perceived Competence and Social Acceptance for Young Children (PCSA; Harter & Pike, 1984) was administered to all participants (N = 54), four subtests were analyzed: cognitive competence, social competence with peers, physical competence in sports, and maternal acceptance. The experimental group (n = 25) attended occupation-based groups two times a week after school. The control group (n = 29) did not participate in an after-school program. Data from pre-test and post-test were analyzed using a t-test. Findings demonstrated that the experimental group improved their self-concept scores when compared to the control group in the areas of peer acceptance and cognitive competence. This would offer tentative evidence that an after-school program directed by occupational therapists that is designed to improve self-concept may be successful.
Profiling alternative food system supporters: The personal and social basis of local and organic food support

Consumers appear increasingly interested in how to engage in consumptive practices that lead to a more sustainable food and agricultural system. In this paper, we examine two possible consumptive pathways for achieving sustainability: the purchase of organic foods and/or the purchase of local foods. While there is some debate regarding the integrity and sustainability of organic versus locally produced foods, there is limited information examining the similarities or differences among consumers variably interested in one or the other attribute. Using data from a statewide survey of Ohio, USA, respondents and members of a food cooperative and an environmental and social responsibility organization, a typology is proposed and comparisons are made among different types of local and organic food consumers regarding their attitudes about food, agriculture and the environment. While a large proportion of the survey respondents expressed little or only modest interest in either local or organic foods, distinct groups of respondents interested in primarily the local attribute, primarily the organic attribute, and both attributes are identified. The results reveal similarities and differences across types with the profiles of each type of consumer contributing to a more nuanced view of supporters of these foods that can assist in production decisions, as well as purchasing and marketing decisions among retailers.
Detailed study of metastable effects in the Cu(InGa)Se2 alloys: Test of defect creation models

We have investigated metastable changes to Cu(InGa)Se2 solar cells in response to infrared optical exposure and forward injection current. Using the drive level capacitance profiling and admittance spectroscopy techniques, we are able to distinguish changes in the free hole carrier concentration from those of a deeper bulk trap. For both types of treatment, changes in these concentrations clearly follow a 1:1 ratio, in agreement with recent predictions of a microscopic model proposed by Lany and Zunger. The creation kinetics follow a strongly sub-linear power law at 250K, and we demonstrate that we can account for this using rate equations in which the metastable effect is initiated by electron capture into an empty defect state. The dependence on time and light intensity is (time) 0.22± 0.03 and (intensity) 0.53± 0.06, except at high light intensities where saturation is observed.
Improvements to a Grating-Based Spectral Imaging Microscope and Its Application to Reflectance Analysis of Blue Pen Inks

A modified design of a chromatically resolved optical microscope (CROMoscope), a grating-based spectral imaging microscope, is described. By altering the geometry and adding a beam splitter, a twisting aberration that was present in the first version of the CROMoscope has been removed. Wavelength adjustment has been automated to decrease analysis time. Performance of the new design in transmission–absorption spectroscopy has been evaluated and found to be generally similar to the performance of the previous design. Spectral bandpass was found to be dependent on the sizes of apertures, and the smallest measured spectral bandpass was 1.8 nm with 1.0 mm diameter apertures. Wavelength was found to be very linear with the sine of the grating angle (R2 = 0.9999995), and wavelength repeatability was found to be much better than the spectral bandpass. Reflectance spectral imaging with a CROMoscope is reported for the first time, and this reflectance spectral imaging was applied to blue ink samples on white paper....
Patternable Conjugated Polymers with Latent Hydrogen-Bonding on the Main Chain

Conjugated polymers with latent hydrogen-bonding on the main chain were synthesized using Suzuki coupling reaction. The resulting polymers with latent hydrogen-bonding can be converted to the actual hydrogen-bonded polymers by thermal annealing or UV irradiation. As the hydrogen-bonding sites are fused with π-conjugated units on the polymer backbone, the intermolecular interactions between the polymer chains will be strongly enhanced when the hydrogen-bonds are formed. By removing the protection group and forming hydrogen-bonding, the polymers exhibited a bathochromic shift over those with latent hydrogen-bonding, indicating a hydrogen-bonding-mediated enhancement of π–π stacking. In addition, the fused hydrogen-bond sites and π-conjugated units led to closely packed polymer chains, resulting in insoluble pigment-like polymers. This drastic solubility change from polymers with latent hydrogen-bonding to hydrogen-bonded polymers can be used to pattern conjugated polymers directly. The photolithography of t...
The Poset of Subpartitions and Cayley's Formula for the Complexity of a Complete Graph

A very well known theorem of Cayley asserts that there are nn−2 distinct trees with vertex set {1,2, …, n}. We can express this result in the language of matroid theory by saying, “The complexity of the complete graph on n vertices is nn−2.”
Conclusion: Technology, Innovation and the Industrial Revolution

In the history of the English wool textile industry during the industrial revolution, the figure of Benjamin Gott is deservedly well known. The son of a local gentleman, he was apprenticed to the Leeds merchant firm of Wormald and Fountain in 1780 and joined them as a junior partner in 1785.1 By 1792, Wormald and Fountain were both dead, and as senior partner Gott significantly reoriented the firm’s business by taking up the production of cloth. The great Bean Ing mill he constructed at Armley, just on the outskirts of Leeds, eventually included workshops for wool preparation, weaving, dying, and finishing, some of which was done with the aid of a large Boulton and Watt steam engine.2 The scale of Gott’s investment, his decision to centralize production, and his use of steam power make his story significant, for he was visibly transforming the production process with these technological and organizational innovations in a way which heralded the industrialization of the wool textile trade. Yet if Gott’s place in the history books is secure, the nature of this industrialization, and Gott’s role in it, requires a closer look.
Change of desired trajectory caused by training in a novel motor task

When the human motor system adapts to novel dynamics of the arm during reaching, hand trajectories tends to converge toward a roughly straight line. This straight line is thought to be the desired trajectory of the system. Trial-to-trial changes in performance are well described by a first order state-space model: errors in a given trial affect performance on the subsequent trial as a function of the distance in state space between the two trials. This function describes the generalization patterns that govern adaptation. Whereas the desired trajectory and the generalization function have been quantified for short-term adaptation, little is known about their behavior with long-term training. We report that when subjects are trained to reach in novel force fields over multiple days, the state-space model suggests that the desired trajectory undergoes systematic changes. In a constant field, the desired trajectory becomes curved. The direction of change of the desired trajectory is affected by the training protocol, such that occasional unperturbed trials (catch trials) caused subject to increasingly under-compensate for the perturbations whereas a lack of such trials caused subjects to increasingly overcompensate for the perturbations. We suggest that the desired trajectory is not constant, but is a result of an optimization that considers the success rate. In this optimization process, subjects weigh more heavily the importance of certain trials: either those that are infrequent or those that cause large errors.
Draft Genome Sequence of the Oleaginous Yeast Cryptococcus curvatus ATCC 20509

Cryptococcus curvatus ATCC 20509 is a commonly used nonmodel oleaginous yeast capable of converting a variety of carbon sources into fatty acids. Here, we present the draft genome sequence of this popular organism to provide a means for more in-depth studies of its fatty acid production potential.
What is Sudden Cardiac Death

Sudden cardiac death (SCD) is a rapid, unexpected death due to cardiac causes. The differential diagnosis includes diseases from all four structural divisions of the heart: the blood vessels, myoca...
Beyond Traditional Measures of STEM Success: Long-Term Predictors of Social Agency and Conducting Research for Social Change

Despite the importance of preparing socially responsible graduates in science, technology, engineering, and mathematics (STEM) to address the current state of poverty and inequality, very few studies in higher education have examined the development of STEM students’ outcomes critical to promoting a more equitable society, typically focusing on the impact of one program or course. To address this gap in the literature, this study used frameworks of undergraduate socialization as well as social justice perspectives in STEM education to examine the undergraduate experiences and institutional contexts that predict STEM bachelor’s degree recipients’ development of two democratic educational outcomes seven years after college entry: social agency and values toward conducting research that will have a meaningful impact on underserved communities. The study utilized multilevel modeling on a national longitudinal sample of 6341 STEM bachelor’s degree recipients across 271 institutions. Longitudinal student data from the 2004 Cooperative Institutional Research Program’s (CIRP) Freshman Survey and 2011 Post-Baccalaureate Survey were merged with institutional data from the Integrated Postsecondary Educational Data System and CIRP Faculty Surveys. Various undergraduate socialization experiences and institutional contexts were found to predict STEM bachelor’s degree recipients’ democratic educational outcomes, including academic majors, participation in student organizations and research, experiences with faculty, and peer and STEM faculty normative contexts. Implications of the findings for research, policy, and practice are discussed.
Hypertensive Disorders of Pregnancy and Offspring Cardiometabolic Health at Midchildhood: Project Viva Findings.

BackgroundExposure to preeclampsia or gestational hypertension is associated with higher offspring systolic blood pressure (SBP), but less is known about associations with other cardiometabolic ris...
Evolution and persistence mechanisms of mouse hepatitis virus

We established and characterized persistently-infected DBT cells with mouse hepatitis virus to study the molecular mechanisms of MHV persistence and evolution in vitro. Following infection, viral mRNA and RF RNA were coordinately reduced by about 70% as compared to acute infection suggesting that the reduction in mRNA synthesis was due to reduced levels of transcriptionally active full length and subgenomic length negativestranded RNAs. Although the rates of mRNA synthesis were also reduced, the relative percent molar ratio of the mRNAs and RF RNAs were similar to those detected during acute infection. In contrast to the finding during BCV persistence, analysis of the MHV leader RNA indicated that the leader RNA and leader/body junction sequences were extremely stable. These data suggested that polymorphism and mutations resulting in intraleader ORFs was not required for MHV persistence. Conversely MHV persistence was significantly associated with a A to G mutation at nt 77 in the 5′ end untranslated region (UTR) of the genomic RNA.
The Hahn–Banach Theorems

Several theorems in functional analysis have been labeled as “the Hahn–Banach Theorem.” At the heart of all of them is what we call here the Hahn–Banach Extension Theorem, given in Theorem 3.4, below. This theorem is at the foundation of modern functional analysis, and its use is so pervasive that its importance cannot be overstated.
Changes in Left Atrial Function After Transcutaneous Mitral Valve Repair

Left atrial (LA) reverse remodeling occurs after transcatheter mitral valve repair, but additional data are needed about changes in LA function. Changes in LA stiffness in patients undergoing MitraClip implantation were evaluated. Baseline, procedural, and 30-day follow-up clinical and imaging data of patients undergoing MitraClip were reviewed. LA operating chamber stiffness was calculated as the ratio of systolic change in LA pressure to LA systolic strain and to stroke volume. Matched preprocedure and postprocedure LA strain analyses were performed in 35 patients, 21 with primary and 14 with functional mitral regurgitation (MR). Procedural success occurred in 34 of 35 cases with significant improvement of all invasive hemodynamic parameters. LA operating chamber stiffness decreased significantly in the overall population (p <0.001). At follow-up, sustained improvement in MR severity occurred, together with left ventricular (LV) and LA reverse remodeling. After MitraClip deployment, LA operating chamber stiffness showed a significant correlation with follow-up pulmonary artery systolic pressure, LV end systolic volume, and LV EF, irrespective of MR etiology (p <0.05). A significant inverse correlation was seen between change in LA operating chamber stiffness and improvement in 6-min walking distance. In conclusion, LA operating chamber stiffness decreases after MitraClip deployment, irrespective of MR etiology. It is related to pulmonary artery systolic pressure and functional status.
Upper Critical Field of Grain Oriented Cuprate Superconductors

One of the striking structural features of the Y1Ba2Cu307−x family of superconductors is the occurrence of twin planes aligned parallel to the c-axis. These materials generally form the proper phase at a temperature near 960°C with an oxygen deficiency with x approaching one. If the sample is cooled in flowing oxygen, gradually oxygen intercalates into the copper layer between the two BaO layers. At a temperature in the 600 to 700°C range, these oxygens order into chains along the b-axis with an accompanying tetragonal to orthorhombic phase transition. The strain associated with this orthorhombic distortion in turn leads to [110] twin planes with the a and b axis interchanged at each twin. Depending on the cooling rate, the grain size and possibly other factors, the twin spacing typically ranges from 20 to 200 nm. Sometimes the spacing is in the pm range or greater. Evidence of these twins is easily seen in a transmission electron microscope or by looking at a polished sample under polarized light.
Pedro Cayuqueo. 2017. Historia secreta mapuche

Book review of Pedro Cayuqueo, Historia secreta mapuche. Santiago de Chile: Catalonia, 2017, pp. 372.
Overcoming Older Adult Barriers to Learning Through an Understanding of Perspectives on Human Information Processing

The importance to older adults of being able to learn to perform activities related to leisure, work, or daily living for maintaining independence and a good quality of life is unquestionable. An appreciation of the challenges that older adults face during learning, as well as insights into ways to help them overcome these challenges, whether through design or instruction, can be obtained through a basic understanding of human information processing. The purpose of this article is to facilitate this understanding within the context of older adult learning. The article begins with an overview of the human information-processing system and cognitive limitations and capabilities associated with aging. Critical components of the information-processing system are then revisited in greater detail from the perspective of older adult information-processing capabilities. Concepts are illustrated through examples to demonstrate how older adults could make more efficient use of their information-processing resources during learning.
Interaction networks of macrofungi and mycophagous beetles reflect diurnal variation and the size and spatial arrangement of resources

Abstract Ecological networks are useful for characterizing interspecific associations and predicting the resilience of ecological communities. We evaluated how such networks vary with the size, spatial distribution, and timing of availability of resources, with a focus on beetle-macrofungal associations. We used 2 y of field experiments to construct ecological networks based on manipulated sporocarp baits (resources; Pleurotus ostreatus) and natural communities of beetles (consumers) in a temperate forest. Centrality and interaction strength increased with resource size, but were associated weakly with resource density and isolation, and not at all with position within patches. Whole-network connectance was greater in mornings (when beetle richness and abundance were high) than evenings. Interannual differences in networks were consistent with differences in beetle communities between years. The capacity of networks to vary temporally, spatially, and as a function of resource traits is examined in light of understanding beetle-macrofungal associations, which are important components of fungal ecology.