cssi/SciSciGPT-SciSciNet huggingface dataset:
Abstract 2978: DNA methylation changes during epithelial-to-mesenchymal transition in ovarian cancer cells.

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Epithelial-to-mesenchymal transition (EMT) is a required step in the process of metastasis and has been linked to cancer cell stemness. We hypothesized that aside from defined genetic changes associated with EMT, epigenetic mechanisms are also involved. We determined DNA methylation changes in SKOV3 ovarian cancer (OC) cells undergoing TGFβ-induced EMT by using the Infinium HumanMethylation450 array. Methylation of sites was expressed as s-values ranging from 0 (completely unmethylated) to 1 (completely methylated). Methylation of 468 and 390 sites changed significantly (P 1.25-fold. The majority of changes (∼66%) reflected TGFβ-induced demethylation. Methylation of 160 sites changed similarly at 48 and 120h indicating that approximately 40% of changes were sustained. PCA analysis demonstrated that the removal of TGFβ was associated with reversal of DNA methylation changes at most sites and restitution of the baseline methylome. Pathway analysis identified DNA methylated genes involved in functional networks relevant to EMT and cancer progression, including: 1) cell morphology and development (39 genes), 2) cell growth and proliferation, and cell death and survival (34 genes), 3) cellular assembly and organization (22 genes), 4) DNA replication, recombination and repair (17 genes), and 5) gene expression, cell signaling, and cellular movement (15 genes). Validation of the relevant genes is ongoing. Treatment of OC cells with the DNA methyl transferase inhibitor SGI-110 prevented TGFβ-induced EMT and reduced by two-fold the number of cells with stem cell characteristics (ALDH1+). These results demonstrate that DNA methylation is a dynamic process involved in regulation of genes implicated in EMT and metastasis. Citation Format: Horacio Cardenas, Chirayu Goswami, Kenneth P. Nephew, Daniela Matei. DNA methylation changes during epithelial-to-mesenchymal transition in ovarian cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2978. doi:10.1158/1538-7445.AM2013-2978
Methodology for an operationally-based test length decision

Weapon systems that function destructively (e.g., missile or torpedo) are to be acquired in a lot of size m. Acceptance of the lot is based on the result of an operational test, administered to part of the lot: if the test results indicate positive operational value the lot is accepted and the remaining part of the lot is fielded; otherwise the lot is “rejected”. A test plan is designed that establishes an optimal number of weapon copies to test, given models of the operational gain of the fielded weapon under two tactical options, and the uncertainty in the weapon's predicted probability of success after the test is complete. The major test objective is to realize possible operational utility from the lot of items, and secondarily to demonstrate arbitrary levels of certainty.
Nutritional stress and growth: sex difference in adaptive response.

Most of the residents of Heliconia, Colombia, live in a continual state of malnutrition characterized by a lack of protein and an excess of carbohydrate in the diet. Kwashiorkor and Marasmus are frequently observed when such dietary imbalances occur. These conditions are seen in Heliconia, but even when the recognized symptoms of clinical malnutrition are absent, there are long-term morphological changes associated with protein deficiency. In the present study, interest is centered on the relative effects of protein deficiency on the skeletal maturation of apparently healthy boys and girls. Incidental comparisons of clinically-diagnosed Kwashiorkor and Marasmus patients with each other and with non-affected controls are also made. It is seen that skeletal maturation in early life is delayed in almost all Heliconia children when compared to U.S. standards. Female controls appear to experience a form of catch-up growth beginning in the preadolescent period, while male controls appear more severely retarded throughout adolescence. The result is a reduction in stature most pronounced in boys and a concomitant reduction in sexual dimorphism for overall body size. The Kwashiorkor- and Marasmus-affected children show a more severe retardation of skeletal growth with no significant sex difference in their response.
The Marketplace Citizen and the Political Economy of Data Trade in the European Union

(1999). The marketplace citizen and the political economy of data trade in the European Union. The Journal of International Communication: Vol. 6, Political Economy, pp. 41-56.
Language support for distributed proxies

Proxies are ubiquitous in distributed systems. They are mainly used to provide transparent access to server objects, and in some cases for additional functions such as caching, message routing, marshalling, and un-marshalling of data. In this paper, we discuss several software engineering problems associated with using proxies in a distributed system. We believe that proxies in distributed systems suffer from: 1) redundant code 2) multiple data translations that have to be written before data is marshalled for transfer over the wire, and 3) in the case when proxies are automatically generated, there is no universal or generic mapping (to date) from XML types to Object types and vice versa. We describe these problems using an example, and discuss the partial solutions provided by prior research. A better understanding of these problems may help show the way towards a future solution.
Fastest mixing Markov chain problem for the union of two cliques

A symmetric, random walk on a graph G can be defined by prescribing weights to the edges in such a way that for each vertex the sum of the weights of the edges incident to the vertex is at most one. The fastest mixing, Markov chain (FMMC) problem for G is to determine the weighting that yields the fastest mixing random walk. We solve the FMMC problem in the case that G is the union of two complete graphs.
Clinical effects of bisphosphonates in involutional osteoporosis

The bisphosphonates are analogs of naturally occurring pyrophosphate. They appear to block bone resorption much more than mineralization. A series of compounds has been investigated. These have antiresorptive potencies ranging from 1 to 10,000. So far, structure-function relationships have eluded definition. These drugs increase the bone density in women with postmenopausal osteoporosis by about 5 5%-10% over 1 year. The bone density then appears to plateau, but most studies are of short duration. Improved bone density does not necessarily result in stronger bone, but no studies have had adequate power to assess fracture incidence. Bone formation rates decrease as measured histomorphometrically
Untangling the X-Ray Emission from the Sa Galaxy NGC 1291 with Chandra

We present a Chandra ACIS-S observation of the nearby bulge-dominated Sa galaxy NGC 1291. The X-ray emission from the bulge resembles the X-ray emission from a subclass of elliptical and S0 galaxies with low X-ray-to-optical luminosity ratios. The X-ray emission is composed of a central pointlike nucleus, ~50 point sources that are most likely low-mass X-ray binaries (LMXBs), and diffuse gas detectable out to a radius of 120'' (5.2 kpc). The diffuse gas has a global temperature of 0.32 keV and metallicity of 0.06 ± 0.02 solar, and both quantities marginally decrease with increasing radius. The hot gas fills the hole in the H I distribution, and the softening of the spectrum of the X-ray gas with radius might indicate a thermal coupling of the hot and cold phases of the interstellar medium as previously suggested. The integrated X-ray luminosity of the LMXBs, once normalized by the optical luminosity, is a factor of 1.4 less than in the elliptical galaxy NGC 4697 or S0 galaxy NGC 1553. The difference in LX, stellar/LB between the galaxies appears to be because of a lack of very bright sources in NGC 1291. No sources above 3 × 1038 ergs s-1 were found in NGC 1291 when ~7 were expected from scaling from NGC 4697 and NGC 1553. The cumulative LX, stellar/LB value including only sources below 1.0 × 1038 ergs s-1 is remarkably similar between NGC 1291 and NGC 4697, if a recent surface brightness fluctuation-determined distance is assumed for NGC 4697. If this is a common feature of the LMXB population in early-type systems, it might be used as a distance indicator. Finally, a bright, variable [(1.6–3.1) × 1039 ergs s-1] source was detected at the optical center of the galaxy. Its spectrum shows excess soft emission superposed on a highly absorbed power-law component, similar to what has been found in several other low-luminosity active galactic nuclei. However, the soft component does not vary in intensity like the hard component, indicating that the soft component is not reprocessed hard component emission.
Determining the effects of introduced species.

Abstract People have moved species around the world for millenia, sometimes by accident, but often with considerable enthusiasm. English garden birds in New Zealand are merely quaint curiosities introduced by settlers wanting the familiar species of their former homes. Some introductions have been devastating — goats or rabbits on various islands, for example. Other introductions, such as those of genetically engineered organisms, present potential problems yet to be considered in any detail. What should we expect the impact of introduced species to be?
Giving Direction and Clarity to Conservation Leadership

Conservation leadership is a term without a widely shared understanding of its scope and meaning. In this article, the author shares perspectives based on interviews, literature, and a survey to begin to identify strategies that define conservation leadership. Results indicate that some elements of conservation leadership are similar to strategies of effective leadership more broadly. Conservation leadership also includes distinguishing aspects, however, such as conflict management and partnership-building. The purpose of this article is to provide some initial thoughts and ideas to address “What is conservation leadership?” The outcomes of this work can assist those in leadership positions and those who teach conservation leadership by defining the skills and strategies necessary to be effective in conservation leadership roles.
The development of an instrument to measure motivation for marathon running: the Motivations of Marathoners Scales (MOMS)

Abstract This study reports the development of an instrument to assess the motives of marathon runners. The Motivations of Marathoners Scales (MOMS) contains 56 items distributed across nine scales. Content areas covered included health orientation, weight concern, self-esteem, life meaning, psychological coping, affiliation, recognition, competition, and personal goal achievement. Adequate internal consistency (Cronbach's alpha range .80 to .93), retest reliability (intraclass Rs range .71 to .90), and factorial validity of the scales were demonstrated. Assessment of the relationship between individual MOMS scales and other variables of conceptual relevance documents early evidence for the convergent and, discriminant validity of the instrument. Future uses of the MOMS are discussed in light of theoretical, empirical, and practical considerations.
Effects of leaf litter depth on the emergence and seedling growth of deciduous forest tree species in relation toseed size1

Abstract Kostel-Hughes, F., T. P. Young, and J. D. Wehr. (Louis Calder Center—Biological Field Station and Department of Biological Sciences, Fordham University, P.O. Box 887, Armonk, NY 10504). Effects of leaf litter depth on the emergence and seedling growth of deciduous forest tree species in relation to seed size. J. Torrey Bot. Soc. 132: 50–61. 2005.—Leaf litter has a major impact on soil microenvironmental conditions and so can be an important influence on seedling recruitment and hence plant community structure. We conducted a greenhouse experiment to examine the impact of leaf litter from temperate deciduous forests on the emergence and growth of tree seedlings in relation to seed size. Our treatments were bare (no litter), shallow (1–2 cm deep, 140 g·m−2), and deep (ca. 5 cm deep, 420 g·m−2) litter. Seed sizes ranged from 0.7–3636 mg. For Betula lenta (seed mass = 0.7 mg), emergence on bare soil was greater than 50%, approximately 12% in shallow litter, and no emergence in deep litter. Percent em...
A Search for Binary Systems among the Nearest L Dwarfs

We have used the Near-Infrared Camera and Multi-Object Spectrometer NIC1 camera on the Hubble Space Telescopeto obtain high angular resolution images of 52 ultracool dwarfs in the immediate solar neighborhood. Nine systems are resolved as binary, with component separations from 1.5 to 15 AU. Based on current theoretical models and empirical bolometric corrections, allsystemshave components with similar luminosities and, consequently,high mass ratios, q > 0:8. Limiting analysis to L dwarfs within 20 pc, the observed binary fraction is 12% þ7 � 3 . Applying Bayesian analysis to our data set, we derive a mass-ratio distribution that peaks strongly at unity. Modeling the semimajor axis distribution as a logarithmic Gaussian, the best fit is centered at loga0 ¼ 0: 8A U (� 6.3 AU), with a (logarithmic) width of � 0.3. The current data are consistent with an overall binary frequency of � 24%.
Glomerulocystic kidney disease

Glomerulocystic disease is a rare renal cystic disease with a long descriptive history. Findings from recent studies have significantly advanced the pathophysiological understanding of the disease processes leading to this peculiar phenotype. Many genetic syndromes associated with glomerulocystic disease have had their respective proteins localized to primary cilia or centrosomes. Transcriptional control of renal developmental pathways is dysregulated in obstructive diseases that also lead to glomerulocystic disease, emphasizing the importance of transcriptional choreography between renal development and renal cystic disease.
Compositional Evolution of FePt Nanoparticles Prepared by Different Organometallic Synthesis Routes

Self-assembled FePt nanoparticle arrays are candidate structures for ultrahigh density magnetic storage media. One of the factors limiting their application to this technology is particle-to-particle compositional variation. In the present study, an analysis is provided for the formation mechanism of FePt nanoparticles synthesized from the thermal decomposition of Fe(CO)5 and the reduction of FeCl2 by superhydride. In both processes, Pt rich seeds initially form from the reduction of Pt acetylacetonate. The particle formation mechanism has been studied by extracting particles at different stages of the synthesis and individually determining particle-to-particle composition by STEM-XEDS. In the case Fe(CO)5, the Fe is gradually incorporated into the Pt seeds and produces a wide variation in compositional distribution about the mean value. In contrast, the FeCl2 has a nearly instantaneous shift in composition to the average value with the introduction of the superhydride reducing agent. The discrepancies in compositional uniformity between the two processes will be discussed in terms of the intrinsic differences between the different precursors.
Prevalence, social contexts, and risks for prepartying among ethnically diverse college students☆

Prepartying, also known as pre-gaming, has emerged as a high-risk drinking event among U.S. college students. Research on factors related to prepartying behavior is in its relative infancy. The present study provides prevalence rates for prepartying across ethnic groups and examines how social context (whether prepartying took place with primarily male, female, or coed groups) and demographic factors may influence prepartying behavior. Participants were students from two West Coast universities (N=2546) whom identified as White, Asian and Pacific Islander American (APIA), Hispanic/Latino(a), or African American. The percentage of students who reported prepartying at least once in the past month, as well as the frequency and number of drinks consumed for prepartying occasions, varied by ethnic group and sex. A greater proportion of White students (60%) reported prepartying than Hispanic/Latino(a) (52%), African American (44%), and APIA (37%) students, though Hispanic/Latino(a) students who prepartied did so as often and consumed similar amounts of alcohol as White prepartiers. Across all ethnic groups, females who reported prepartying in coed groups consumed significantly more drinks than those who prepartied in primarily female groups. Finally, prepartiers within all ethnic groups consumed more drinks per week and experienced a higher number of alcohol-related consequences than non-prepartiers. The results suggest that future research and prevention programs should target prepartying and other high-risk events in at-risk students of ethnically diverse backgrounds and also consider the effects of gender in prepartying contexts on alcohol use. Language: en
Properties of primary motor cortex output to forelimb muscles in rhesus macaques

Stimulus-triggered averaging (StTA) of electromyographic (EMG) activity from 24 simultaneously recorded forelimb muscles was used to investigate properties of primary motor cortex (M1) output in th...
SRUMMA: a matrix multiplication algorithm suitable for clusters and scalable shared memory systems

Summary form only given. We describe a novel parallel algorithm that implements a dense matrix multiplication operation with algorithmic efficiency equivalent to that of Cannon's algorithm. It is suitable for clusters and scalable shared memory systems. The current approach differs from the other parallel matrix multiplication algorithms by the explicit use of shared memory and remote memory access (RMA) communication rather than message passing. The experimental results on clusters (IBM SP, Linux-Myrinet) and shared memory systems (SGI Altix, Cray XI) demonstrate consistent performance advantages over pdgemm from the ScaLAPACK/PBBLAS suite, the leading implementation of the parallel matrix multiplication algorithms used today. In the best case on the SGI Altix, the new algorithm performs 20 times better than pdgemm for a matrix size of 1000 on 128 processors. The impact of zero-copy nonblocking RMA communications and shared memory communication on matrix multiplication performance on clusters are investigated.
Robert Munford and the Political Culture of Frontier Virginia

Robert Munford, the eighteenth-century Virginia squire and litterateur, has long served as both a symbol and subject of analysis for students of colonial American history and culture. In the nearly-barren ground of eighteenth-century American drama, Munford's plays, The Candidates and The Patriots, while never actually produced on stage during his lifetime, stand out as two of the most important attempts by a colonial American to use traditional dramatic techniques to illustrate distinctively American characters and themes. And for historians, these same two plays, which grew out of Munford's own experience in Virginia politics, have served as rich and evocative sources from which to reconstruct the operation and ethos of the political culture of revolutionary Virginia.
Development of CORBA components in COBOL for reusability and interoperability

We present an adapter for implementing reusable and interoperable CORBA components in COBOL. For organizations using an open-source implementation of a CORBA that has not yet supported for COBOL, the work discussed in this paper helps them improve their CORBA middleware implementations to support COBOL interoperability.
Vasopressin in the forebrain of common marmosets (Callithrix jacchus): studies with in situ hybridization, immunocytochemistry and receptor autoradiography

The distribution of vasopressin AVP producing cells, their projections and AVP receptors was examined in the brain of common . marmosets Callithrix jacchus using in situ hybridization, immunocytochemistry and receptor autoradiography. Clusters of cells labeled . . . for AVP mRNA or stained for AVP immunoreactivity AVP-ir were found in the paraventricular PVN , supraoptic SON and . suprachiasmatic nuclei SCN of the hypothalamus. Scattered AVP producing cells were also found in the lateral hypothalamus and the . bed nucleus of the stria terminalis BST . Neither AVP mRNA-labeled nor AVP-ir cells were detected in the amygdala. Although AVP-ir fibers were evident outside of the hypothalamic-neurohypophyseal tract, a plexus of fibers in the lateral septum, as observed in the rat brain, was not detected. Receptor autoradiography using 125 I-linear-AVP revealed specific binding for AVP receptors in the nucleus accumbens, diagonal band, lateral septum, the BST, SCN, PVN, amygdala, anterodorsal and ventromedial nucleus of the hypothalamus, indicating sites for central AVP action in the marmoset brain. Together, these data provide a comprehensive picture of AVP pathways in the marmoset brain, demonstrating differences from rodents in the distribution of cell bodies, fibers and receptors. q 1997 Elsevier Science B.V.
Do They Mean What They Say? Sociopragmatic Competence and Second Language Learners.

guage comprises more than linguistic and lexical knowledge. It implies that the speaker knows how to vary speech-act strategies according to the situational or social variables present in the act of communication. Knowledge of the interdependence that exists between linguistic forms and sociocultural context is particularly important today, given the central role that discourse functions play in methodologies and approaches to language teaching. This paper begins with a rationale for research into what constitutes sociopragmatic competence; reviews a series of relevant empirical studies; and reports on one such study of requests, thanks, and apologies made by native speakers and nonnative learners of French. The results are discussed in terms of the influence of the social variables of age, sex, and familiarity between speakers upon the realization of these speech acts. Differences found in speech-act strategies employed by the two groups lead to implications for classroom teaching, as well as textbook writing. The basic principle upon which discussions of speech acts and associated competencies are based is that language is used for communication. The term "communicative competence," introduced by Hymes, implies that a speaker must possess several types of knowledge in order to understand and communicate success-
Practitioner Preferences and Receptivity for Patient-Specific Advice from a Therapeutic Monitoring System

To examine the optimal design of advisories generated from an inpatient therapeutic monitoring system, we solicited practitioner ratings of four formats for three sample patient-specific advisories as well as their overall receptivity to such a monitoring system. Forty-one physicians and pharmacists including community practitioners (n=10), academic medical center internists (n=11), Veterans Administration general medicine attendings and senior medicine residents (n=9), and clinical pharmacists on the faculty of an academic medical center (n=11), participated in the study. Overall, two relatively “terse” advisories, communicating in phrases and sentence fragments, were rated more favorably than more elaborated advisories communicating the information in narrative form. The participants expressed a high receptivity to the use of a therapeutic monitoring system (4.93 on a six-point scale, with “6” representing the highest level of receptivity). The results will be used to direct the design of the advisories for one therapeutic monitoring system.
Emotion Regulation and Sex Addiction among College Students

For individuals with sexual addiction, sexual behaviors often are the primary means of regulating distressing or undesirable emotion. In this study, we sought to examine differences in aspects of emotion regulation between students in the clinical range of sexual addiction and those in the nonclinical range. Among a sample of 337 college students, 57 (16.9 %) scored in the clinical range of sexual addiction and students in the clinical range differed significantly from students in the nonclinical range on three aspects of emotion regulation: (a) nonacceptance of emotional responses, (b) limited engagement in goal-directed behaviors in response to negative affect, and (c) minimal emotion regulation strategies. Implications for interventions on college campuses are provided.
A Diffusion Tensor Imaging Analysis of White Matter Disease in Corticobasal Syndrome (P05.041)

Objective: To determine the regions of white matter (WM) atrophy in corticobasal syndrome (CBS) using different methods of diffusion tensor imaging (DTI) analysis. Background CBS is a clinical syndrome mostly associated with frontotemporal lobar degeneration (FTLD), where gray matter atrophy predominantly encompasses frontal and parietal lobes. Although little is known about the pattern of WM disease in CBS, it is known that tau, the histopathological basis of corticobasal degeneration (CBD), has substantial WM burden. For neurodegenerative diseases, there is no gold standard for MRI-based WM analysis. Here, we compared two user-independent approaches in analyzing WM: tract-specific analysis (TSA) and whole-brain analysis. Both used fractional anisotropy (FA), which is sensitive to the integrity of white matter fiber tracts. Design/Methods: In 11 CBS patients and 35 demographically-matched healthy seniors, we analyzed 30-direction diffusion-weighted images. We extracted FA for each individual subject, and registered the image to a common stereotactic space. For TSA, 11 tracts were segmented from a DTI template, converted to 3D binary structures, and modeled as medial meshes to reflect maximum FA locally. For the whole-brain analysis, images were analyzed in local space, localized to a publicly available probabilistic template (ICDM-DTI-81), and then compared statistically with seniors in SPM8. Results: TSA revealed reduced FA in CBS relative to seniors in right uncinate, arcuate fasciculus, and inferior frontal-occipital fasiculus; and bilateral corpus callosum, corticospinal tract and superior longitudinal fasiculus. Whole-brain analysis also revealed reduced FA relative to seniors in the corpus callosum, corticospinal tract, fornix, inferior longitudinal fasiculus, superior longitudinal fasciculus, inferior frontal-occipital fasiculus, and external capsule. Conclusions: In addition to grey matter atrophy, CBS patients have considerable WM disease. TSA and whole-brain analyses display largely overlapping findings, validating user-independent approaches to DTI analyses of WM disease. Supported by: HD060406, NS44266, NS53488, AG15116, AG17586, AG32953, the Wyncote Foundation, NS065347, DA022807, EB006266, NS045839, EB009321, K25 AG027785. Disclosure: Dr. Chandrasekaren has nothing to disclose. Dr. McMillan has nothing to disclose. Dr. Brun has nothing to disclose. Dr. Cook has nothing to disclose. Dr. Yushkevich has nothing to disclose. Dr. Gee has received research support from Pfizer Inc. Dr. Grossman has nothing to disclose.
Noninvasive and Invasive Sensors for Patient Monitoring

Technologic advances have revolutionized the clinical laboratory over the years and, most recently, the development and miniaturization of electrochemical sensors, biosensors, and fiber-optic sensors have allowed testing to move closer to the patient. This includes noninvasive and invasive sensors that provide continuous monitoring of patient condition in real time. Noninvasive sensors include pulse oximetry, transcutaneous electrodes for Po2 and Pco2, and transcutaneous bilirubin monitors. Continuous invasive systems include ex vivo monitors for pH and blood gases that may use fluorescence chemistry or optical or electrochemical sensors and fiber-optic sensors for continuous in vivo monitoring ofpH and blood gases. Several of the newest advances in noninvasive monitors involve the analysis of glucose in patients with diabetes.
Viewing Teaching and Learning from a New Angle:Student Consultants' Perspectives on Classroom Practice

ABSTRACTThis qualitative case study describes how undergraduate students positioned as pedagogical consultants use several observational techniques to help faculty view their classroom practice from a new angle. It includes a brief review of literature on students as active partners with faculty in explorations of pedagogical approaches and a short description of one program that supports such partnerships. The majority of the article focuses on the observational techniques student consultants in this program use, highlighting the benefits to those faculty members and to students enrolled in the faculty members' courses and touching on benefits to student consultants.
Orbital cellulitis and corneal ulcer due to Cedecea: First reported case and review of the literature

Cedecea is a gram-negative bacterium from the family Enterobacteriaceae, rarely associated with human infection. We report the first case of an orbital cellulitis and corneal ulcer due to Cedecea in a patient who sustained a motor vehicle accident and was then found to have a retained wooden orbital foreign body.
Discovery to Improve Inner Control System of Coal Enterprise

From the conception of the inner control, framework understanding and the present status of the inner control in the coal enterprise, the paper analyzed the five reasons to cause the inner control problems of the coal enterprise and provided 4 countermeasures to improve the inner control of the coal enterprise.
Seven stories of performativity and advocacy: a review of the published work of Stephen Town

Purpose – Stephen Town has been a thought leader and change agent in the academic library world for more than 20 years, who has produced a very large body of work in the areas of quality management and performance measurement that has been disseminated internationally. Town’s retirement from full-time employment at the University of York provides a timely opportunity to review his contribution to the field. The purpose of this paper is to discuss this issue. Design/methodology/approach – The review outlines Town’s career path and professional interests and then appraises his published output, concentrating on his contributions to thinking and practice in the areas of benchmarking, information literacy, service quality, and measuring the value and impact of academic libraries and information services. The discussion is organized thematically to illustrate the evolution and development of his interests and ideas over the review period and also references-related work by other authors to set his work in cont...
Coming out like a porn star: essays on pornography, protection, and privacy

Here's the thing about coming out: It doesn't happen just once. It isn't a thing you do and get done. It happens again and again. It happens over and over and over and it is never over. (Lorelei Le...
NBTI impact on transistor and circuit: models, mechanisms and scaling effects [MOSFETs]

We describe a quantitative relationship between I/sub D/ and V/sub T/ driven NBTI specifications. Mobility degradation is shown to be a significant (/spl sim/40%) contributor to I/sub D/ degradation. We report for the first time, degradation in gate-drain capacitance (C/sub GD/) due to NBTI. The impact of this C/sub GD/ degradation on circuit performance is quantified for both digital and analog circuits. We find that C/sub GD/ degradation has a greater impact on the analog circuit studied than the digital circuit. We demonstrate that there is an optimum operating voltage that balances NBTI degradation against transistor voltage headroom. Further, a numerical model based on the reaction-diffusion theory has been developed, which is found to satisfactorily describe degradation, recovery and post-recovery response to stress.
A decoupled three-phase power flow algorithm for distribution networks containing multi-transformer-branches

Based on the phase transform technique, the phase transformation matrix is established according to the phase shift relations of three-sequence state variables between two sides of transformer. A novel processing method of transformer branches is proposed, which can be efficiently introduced into a decoupled three-phase power flow algorithm for distribution networks containing multi-transformer-branches. The proposed algorithm makes full use of the characteristics of phase transform and decoupled three-sequence. Then based on the sequence path matrix generated by loop analysis, the relationship between node sequence voltage and injection sequence current can be derived, thus the decoupled three-phase power flow calculation can be successfully realized for unbalanced three-phase distribution networks containing multi-transformer-branches. Finally, the simulated results of IEEE 34-bus test system are provided to verify the correctness and effectiveness of the proposed algorithm, which can also show that this algorithm possesses higher computational efficiency, better convergence, and stronger ability to deal with transformer branches. Different connecting types of transformer and the impacts on unbalanced degrees and distributed levels of three-phase voltages are also discussed in detail.
Disparities in Aesthetic Procedures Performed by Plastic Surgery Residents.

Background Operative experience in aesthetic surgery is an important issue affecting plastic surgery residents. Objectives This study addresses the variability of aesthetic surgery experience during plastic surgery residency. Methods National operative case logs of chief residents in independent/combined and integrated plastic surgery residency programs were analyzed (2011-2015). Fold differences between the bottom and top 10th percentiles of residents were calculated for each aesthetic procedure category and training model. The number of residents not achieving case minimums was also calculated. Results Case logs of 818 plastic surgery residents were analyzed. There was marked variability in craniofacial (range, 6.0-15.0), breast (range, 2.4-5.9), trunk/extremity (range, 3.0-16.0), and miscellaneous (range, 2.7-22.0) procedure categories. In 2015, the bottom 10th percentile of integrated and independent/combined residents did not achieve case minimums for botulinum toxin and dermal fillers. Case minimums were achieved for the other aesthetic procedure categories for all graduating years. Conclusions Significant variability persists for many aesthetic procedure categories during plastic surgery residency training. Greater efforts may be needed to improve the aesthetic surgery experience of plastic surgery residents.
The dead curator: Education and the rise of bureaucratic authority in natural history museums, 1870–1915

ABSTRACTThe dismantling of the Jenks Museum of Natural History at Brown University illustrates a shift from charismatic to bureaucratic authority in museums and its implications for museum education. J.W.P. Jenks, the museum’s founder and curator, died in 1894. Without Jenks’s constant effort on behalf of the museum, his collection deteriorated. Reacting against cabinet displays like those of the Jenks Museum, progressive ‘museum men’ like Brown alumnus Hermon Carey Bumpus developed new, de-personalised approaches to specimen-based museum education, including exhibitions and detailed object labels. At the American Museum of Natural History, these modes routinised interpretation for large urban audiences. At the same time, staff members in bureaucratic museums became more interchangeable. As museums expanded according to corporate and bureaucratic principles, the personalised, idiosyncratic interactions offered by educators like Jenks gave way to more systematized experiences that did not depend upon parti...
The Scope and Autonomy of Personal Narrative

The work of Carol Berkenkotter and others who have expanded the realm of personal narrative studies over the past several decades would not have been possible without the pioneering efforts of thos...
Don't call it a comeback: academic recovery and the timing of educational technology adoption

Recent research using learning analytics data to explore student performance over the course of a term suggests that a substantial percentage of students who are classified as academically struggling manage to recover. In this study, we report the result of a hazard analysis based on students' behavioral engagement with different digital instructional technologies over the course of a semester. We observe substantially different adoption and use behavior between students who did and did not experience academic difficulty in the course. Students who experienced moderate academic difficulty benefited the most from using tools that helped them plan their study behaviors. Students who experienced more severe academic difficulty benefited from tools that helped them prepare for exams. We observed that students adopted most tools and system features before they experienced academic difficulty, and students who adopted early were more likely to recover.
Analysis of self-consistent nonlinear wave-particle interactions of whistler waves in laboratory and space plasmas

Whistler mode chorus is one of the most important emissions affecting the energization of the radiation belts. Recent laboratory experiments that inject energetic electron beams into a cold plasma have revealed several spectral features in the nonlinear evolution of these instabilities that have also been observed in high-time resolution in situ wave-form data. These features include (1) a sub-element structure which consists of an amplitude modulation on time-scales slower than the bounce time, (2) closely spaced discrete frequency hopping that results in a faster apparent frequency chirp rate, (3) fast frequency changes near the sub-element boundaries, and (4) harmonic generation. In this paper, we develop a finite dimensional self-consistent Hamiltonian model for the evolution of the resonant beam of electrons. We analyze a single wave case and demonstrate that the instability occurs due to a Krein collision, which manifests as a coupling between a negative and positive energy mode. This analysis revea...
Charge Localization after Ultrafast Photoexcitation of a Rigid Perylene Perylenediimide Dyad Visualized by Transient Stark Effect.

The intramolecular charge-transfer (CT) dynamics of a rigid and strongly conjugated perylenediimide-bridge-perylene dyad (PDIPe) has been investigated in dichloromethane using ultrafast transient electronic absorption spectroscopy and quantum chemical calculations. The strong electronic coupling between the dyad units gives rise to a CT band. Its photoexcitation forms a delocalized CT state with well-preserved ion bands despite the strong coupling. In the dyad, the electronic transition dipole moment of the electron donor perylene is aligned along the axis of the electric field vector with respect to the CT species. This alignment makes the donor sensitive to the Stark effect and thus charge density fluctuations in the CT state. Charge localization on the picosecond time scale manifests as a time-dependent Stark shift in the visible region. Quantum chemical calculations reveal a twist around the acetylene bridging unit to be the responsible mechanism generating a partial to an almost complete CT state. An...
Control methods to achieve soft-transition of gains for a variable (n/m)X converter

Switched capacitor based converters derived from the original Dickson converter have a huge potential in meeting high power density and high efficiency demands of the power electronics industry. Originally, this type of converters offered high efficiency only at fixed voltage gains. Recently, a variant of the Dickson converter, termed as the (n/m)X converter has been proposed. The (n/m)X converter can achieve variable and fractional gains without compromising its efficiency. But, higher peak input transient current during transition from one gain level to another may lead to overvoltage stress across individual devices when compared to the fixed-gain switched capacitor converters. This is a limiting factor as the power level is increased. In this paper, two control methods are proposed to reduce/eliminate this peak current transient occurring during gain transition from one level to another. The overvoltage transient across individual switches is also eliminated. Experimental results from a 1-kW prototype validate the proposed methods.
Mediated Nostalgia: touching the past in Reply 1994

ABSTRACT‘Mediated Nostalgia: Touching the Past in Reply 1994’ argues that the aesthetic and thematic treatment of television technology in the nostalgic 2013 South Korean television drama Reply 1994 puts viewers productively in ‘touch’ with the past. The high definition aesthetics of the 2013 series and the low definition image of 1990s television and other domestic media featured in Reply 1994 produce viewing modes that oscillate between closeness and distance. While watching, the viewer enters a sensory dialogue with the medium of television in its dual guise as a cathode ray tube monitor and flat screen. The sensory interaction with memories of the recent past that materialize in her present disturbs the linearity of cosmological time with the time of mediated phenomenological experience. This nostalgic dialogue is not a trivial consumption of meaningless images but a powerful interaction with the past which produces a new version of history about politics and about media. By putting analogue and digit...
EVALUATION OF HERCON LAMINATED DISPENSERS BAITED WITH Z,Z-3,13-OCTADECADIEN-l OL ACETATE FOR SUPPRESSION OF THE GRAPE ROOT BORER, VITACEA POLISTIFORMIS (HARRIS), (LEPIDOPTERA: SESIIDAE), POPULATIONS IN GRAPES

Z,Z-3,13-Octadecadien-l ol acetate (hereafter called Z,Z-ODDA), the major pheromone component of the peachtree borer, Synanthedon exitiosa (Say), was evaluated in grape vineyards in Arkansas and No...
Trend and causes of neonatal mortality in a level III children’s hospital in Shanghai: a 15-year retrospective study

To determine the trend and causes of neonatal mortality in a large level III neonatal intensive care unit in Shanghai during a 15-year period. This is a retrospective, single-centered study. All neonates who died during the period from January 1, 1999 to December 31, 2013 at Children’s Hospital of Fudan University were included. We extracted relevant clinical information from their medical records, analyzed neonatal mortality rate and the characteristics of these patients, and compared neonatal deaths between different periods and populations. Among a total of 50,957 admissions during the study period, there were 929 neonatal deaths. The neonatal mortality rate was 1.82%. Trends in neonatal mortality rate showed an increase in the period from 1.0% in 2003 to 2.2% in 2013. The main causes of neonatal mortality were complications of preterm birth (33.6%), congenital anomalies (21.3%), infections (12.6%), and birth asphyxia (9.1%). The proportions of complications of preterm birth (P < 0.001) and congenital anomalies (P = 0.018) increased yearly, while the proportions of birth asphyxia (P < 0.001) and infections (P < 0.001) decreased. Proportions of deaths caused by birth asphyxia (P = 0.005) and infections (P < 0.001) were both higher in the migrating population than in the permanent residents. Neonatal mortality rate increased from 2003 to 2013 in our study. The proportion of preterm infants in neonatal deaths also increased within the same period. Complications of preterm birth were the main cause of neonatal mortality and the percentage increased year by year. Neonates in the migrating population appeared to be at a higher risk of death during the neonatal period compared to those in the permanent residents, and efforts should be made towards improving perinatal care to prevent infections and birth asphyxia in this vulnerable population.
Nonlinear Time Series: Models and Simulation

Most financial time series exhibit nonlinear features which cannot be captured by the linear models seen in the previous two chapters. In this last chapter, we present the elements of a theory of nonlinear time series adapted to financial applications. We review a set of standard econometric models which were first introduced in the discrete time setting. They include the famous, ARCH, GARCH, … models, but we also discuss stochastic volatility models and we emphasize the differences between these concepts which are too often confused. However, because of the growing influence of the theoretical developments of continuous time finance in the everyday practice, we spend quite a significant part of the chapter analyzing the time series models derived from the discretization of continuous time stochastic differential equations.
West Indian Archaeology. 3. Ceramic Age

Irving Rouse once calculated that more than 90% of all pre-Columbian artifacts from the West Indies are made of clay. It should, therefore, come as no surprise that the vast majority of research in the region has focused on the ceramic age cultures. The review begins by considering the early ceramic age peoples whose pottery is classified as part of the Saladoid series. These peoples entered the Antilles about 500 B.C. and settled all of the islands as far north as Puerto Rico. For as yet unknown reasons their northward progress was halted in Puerto Rico for nearly 1000 years. The post-Saladoid cultures of the Lesser Antilles, about whom very little is known, and the so-called “Ostionoid” peoples of the Greater Antilles and Bahama archipelago are discussed next. New, detailed studies of subsistence, settlement patterns, social organization, and iconography are contributing to a richer knowledge of the patterns and processes of cultural evolution in an insular setting.
New SNP Markers to Identify Culex Complex Species (Diptera: Culicidae) by High-Resolution DNA Melting Analysis

The members from Culex pipiens complex are the primary vector of various arboviruses including West Nile virus and Eastern equine encephalitis in the United States. Within Cx. pipiens complex, there are three biotypes that differ largely in habitat, bloodmeal preference, mating behavior, and overwintering strategy. The three biotypes are Cx. pipiens form molestus (F.) (Diptera: Culicidae), Cx. pipiens f. pipiens (L.) (Diptera: Culicidae), and Cx. pipiens quinquefasciatus (Diptera: Culicidae) (also known as Cx. quinquefasciatus). It is clear that additional genetic markers, molecular markers based on single nucleotide polymorphisms (SNPs), were identified from the Cx. pipiens complex species. Genomic DNA was extracted from adult females of f. pipiens and f. molestus and was amplified by polymerase chain reactions. Thirty out of the 100 primer pairs showed amplification and were used for SNP identification. All thirty genes contained biotype-specific SNPs: 10 were located on the Cx. pipiens complex genetic map from previous genetic studies. We also tested a high-resolution DNA melting analysis as a biotype identification method by examining the SNPs in the two genes (CPIJ005487 and CPIJ002074). Our method provides a high confidence for biotype determination among the three Cx. pipiens complex mosquitoes.Data deposition: NCBI SNP Database (ssSNP accession nos.: ss947848635-ss947848878).